Podcasts about Parkinson

Riley Kirkpatrick is back from the wilderness of the PNW! A super skilled Farrier, Blacksmith, Bladesmith Podcaster and maker of things we had a great time catching up, telling stories and talking weird wilderness news with an incredible family secret that Riley has. (Probably not a secret, but you know how I do.) Many thanks to my man Riley that was fun. - GF Follow Riley on Instagram: https://www.instagram.com/kirkpatrickforge?igsh=MTZsdnJsaXhjMHRkbA==Go to Riley's website: Home | kirkpatrickforgeListen to the Forging Brains Podcast:https://podcasts.apple.com/us/podcast/forging-brains-podcast/id1646071859The Full Blast Podcast on Instagram:https://instagram.com/thefullblastpodcast?igshid=YmMyMTA2M2Y=If you want to support my race for the NYC Marathon as I raise money for Parkinson's Research please do here:https://give.michaeljfox.org/fundraiser/6151559 If you want to support Full Blast Support  Feder Knives - ( go buy a shirt )https://www.federknives.com/Go to CMA's website and check out the opportunities: https://centerformetalarts.org/Take a class: https://centerformetalarts.org/Follow CMA on Instagram https://www.instagram.com/centerformetalarts/?hl=enPlease subscribe, leave a review and tell your friends about the show. it helps me out a lot! Welcome aboard Phoenix Abrasives!Phoenixabrasives.com Phoenix abrasives supplies superior abrasive products for every application. Knifemaking, Metal fabrication, glass fab, floor sanding and Crankshaft! Belts, grinding and cutting discs, Flap Discs, surface conditioning FB10 at checkout gets 10% off your order at Check out.Welcome back! Nordic Edge:@nordic_edge on IG Nordicedge.com.auNordic Edge is about the joy of making something with your own hands. our one stop shop for tools, supplies and help when it comes to knife making, blacksmithing, leatherworking, spoon carving and other crafts where you get to take some time out for yourself and turn an idea into something tangible. Nordic Edge also holds hands-on workshops in the “lost arts” of blacksmithing, knife making and spoon carving. Come spend a day with us and go home with new skills and something you made with your own hands. They have the  guidance to help accelerate your creativity and the  Tools, products, supplies to help you manifest your ideas. NordicEdge.com.auThank you Baker Forge & Tool for your beautiful Steel. Go to Bakerforge.com to see all the incredible steels they offer. ‘FullBlast' gets you 10% off your order. 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Hansen & Sons On Instagramhttps://instagram.com/g.l._hansenandsons?igshid=MzRlODBiNWFlZA== Gcarta.bigcartel.comG-Carta is unique composite of natural fibers and fabrics mixed with epoxy under pressure and heat Boofa, ripple cut, Tuxini, by Mikie, Mahi Mahi, Radio worm g-cartaPheasant by MikieColorama by MikieHoopla by MikeAmazing colors and razzle dazzle for your project. MARITIME KNIFE SUPPLIESMaritimeknifesupply.CAAll your knifemaking needs, belts abrasive, steals, kilns forges presses, heat treating ovens anvils and everything you need to get started or resupply. Including Dr. Thomas's book:“Knife Engineering”They're in Canada but ship to the US with ease and you can take advantage of the exchange rate The steel selection is always growing and Lawrence just got 3900 lbs. of steel in.10% off on abrasive belt packs of 10 get a hold of https://www.instagram.com/maritimeknifesupply/ and see what the fuss is about.Welcome Tormek as a sponsor to the show. Take your sharpening to a new level. I love these sharpening machines. Waterfed, easy to use. Jigs included. Definitely check out what they have to offer. If you need it sharpened, Tormek is definitely something for you:https://tormek.com/en/inspiration/woodworking--craftsVisit Tormek's website: https://tormek.com/enFollow Tormek on Instagram:https://www.instagram.com/tormek_sharpening/?hl=enFollow Tormek on TikTokhttps://www.tiktok.com/@tormek_sharpening?lang=enGo look at the course curriculum at CMA:https://centerformetalarts.org/workshops/** Taking classes from some of the best in forging at one of the best facilities in the country is an excellent opportunity to propel yourself as a blacksmith. Not to be missed. And with housing on the campus it's a great way to get yourself to the next level. Advertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

Two tragedies in one week exposed something many conservatives had been denying: we are not all Americans working toward the same goals. When one side celebrates assassination and the other extends olive branches, the asymmetry becomes fatal. If you believe in traditional values, speak openly about Christ, or question progressive orthodoxy, they consider you deserving of violence. The second half of the episode pivots to Parkinson's Law and its application to both time and money. Work expands to fill the time allowed, expenses rise to meet income, and luxuries become necessities. Without forced savings mechanisms like Infinite Banking and cash flow systems, lifestyle inflation will consume every raise and prevent wealth accumulation. The connection is direct: mastering money flow gives you control over time, and controlling your time means living the life you want now rather than deferring everything to a retirement that may never come.Chapters:00:35 - Opening 02:15 - Ukrainian train murder and Charlie Kirk assassination05:10 - The celebration of violence by the left09:45 - The leftist flowchart for responding to violence11:40 - The myth of "national conversation" exposed14:30 - First Amendment misunderstanding and employment consequences16:30 - Cancel culture hypocrisy: bodily autonomy vs. speech24:10 - DC transformation through force: crime to safety overnight25:20 - Parkinson's Law 26:30 - Becoming Your Own Banker30:30 - Forced savings through IBC vs. flexible premium policies32:20 - Why UL and IUL policies fail at 90%+ rates37:30 - Funneling raises into policy premiums to avoid lifestyle inflation38:00 - Tax refund strategy40:50 - Closing thoughts and call to actionKey Takeaways:- Political violence is almost exclusively a leftist phenomenon- Celebration of Charlie Kirk's murder came from mainstream sources, not fringe accounts- The "national conversation" narrative was always a lie - they want compliance, not dialogue- Losing your job for speech is not a First Amendment violation- First Amendment protects you from government censorship, not employer consequences- Same people demanding speech consequences for conservatives opposed vaccine mandate employment termination- Work expands to fill the time envelope allowed- Expenses rise to equal income without intervention- Luxuries once enjoyed become necessities (air conditioning, heated seats, smartphones)- Without forced mechanisms, lifestyle inflation consumes all income increasesGot Questions? Reach out to us at info@remnantfinance.com or book a call at https://remnantfinance.com/calendar !Visit https://remnantfinance.com for more informationLow Stress Trading: https://remnantfinance.com/options FOLLOW REMNANT FINANCEYoutube: @RemnantFinance (https://www.youtube.com/@RemnantFinance )Facebook: @remnantfinance (https://www.facebook.com/profile.id=61560694316588 )Twitter: @remnantfinance (https://x.com/remnantfinance )TikTok: @RemnantFinanceDon't forget to hit LIKE and SUBSCRIBE

⚠️ WARNING: This episode will challenge everything you think you know about health. “Obesity kills more people worldwide every year than car crashes, terrorism, Alzheimer's, Parkinson's, and malnutrition combined.” In this eye-opening episode of Start Today, I bring you Dr. Saman Soleymani—a no-BS physician and entrepreneur running over a dozen practices—who exposes how Big Pharma and Big Food profit from disease while ignoring the #1 factor that could save your life: nutrition. From the obesity epidemic to GLP-1 drugs, testosterone, antidepressants, and birth control, Dr. Soleymani rips the lid off the lies that are killing people every single day. We uncover why waist size is the ultimate death predictor, how visceral fat destroys men's hormones, why SSRIs don't cure depression, the promising science of psilocybin, and the dangerous side effects of hormonal birth control that no one talks about. No fluff. No sugarcoating. Just the truth you need if you want to take back control of your body, your health, and your future.

This week we bring all of it together—training breakthroughs, fandom debates, and the power of community—with NYT bestselling author AJ Wolfe, the voice behind Disney Food Blog and AllEars. We dig into her book Disney Adults asking why the label sparks so much heat online, and how subcultures like DisneyBounding, Dapper Days, and RunDisney become places people actually live. AJ doesn't sugarcoat it: the same fans who keep the parks humming can be a pain for the company—and each other—yet they're also the first to show up with support, charity dollars, and creative traditions that make the magic feel personal.We keep it real on training, too. Greg crushes his magic half mile and stares down faster paces; Alysha returns stronger after injury thanks to strength and consistency; and Bob talks honestly about listening to your body, walking long runs, and knowing the difference between “owie” and injury. Our Wine & Dine merch take is practical—smart layers beat closet clutter—and AJ drops festival strategy: weekday mornings, skip the worst lines, and aim for raclette, poutine, and solid plant-based picks. We also spotlight the Parkinson's Foundation: how to grab charity bibs, the perks you get, and fundraising tactics that actually work (start early, share your why, leverage matching gifts, and thank like you mean it).The race report brings the color: a hot Berlin Marathon with slick water stops, booming spectators, and even an inline marathon flying past; humid Florida miles with thin hydration but top-tier vibes; stadium hills, muddy dog runs, and a squawking chicken medal you need to see to believe. Episode 210 is a full plate of running, Disney culture, and community wins—proof that better training, better races, and better trips all start with better questions.If this episode made you think, laugh, or plan your next finish line, tap follow, share it with a friend, and leave a quick review. What did we get right about Disney adults—and what did we miss?Disney Food BlogALLEars.netDisney Adults BookParkinson's FoundationRise and Run LinksRise and Run Podcast Facebook PageRise and Run Podcast InstagramRise and Run Podcast Website and ShopRise and Run PatreonRunningwithalysha Alysha's Run Coaching (Mention Rise And Run and get $10 off)Send us a textSupport the showRise and Run Podcast is supported by our audience. When you make a purchase through one of our affiliate links, we may earn a commission. As an Amazon Associate we earn from qualifying purchases.Sponsor LinksMagic Bound Travel Stoked Metabolic CoachingRise and Run Podcast Cruise Interest Form with Magic Bound Travel Affiliate LinksRise and Run Amazon Affiliate Web Page Kawaiian Pizza ApparelGoGuarded

Todo el audio presenta una mezcla de noticias, entretenimiento, publicidad y segmentos interactivos. En las noticias, se informa sobre el asalto del ejército israelí a 21 de 44 embarcaciones, con Greta Thunberg entre los activistas detenidos. Se debate el caso de Begoña Gómez, donde un jurado popular decidirá si es culpable o inocente. Se anuncia un avance en la investigación del Parkinson, con el descubrimiento de las proteínas responsables de su inicio. Para octubre, se actualizará el examen del carné de conducir con nuevas preguntas sobre patinetes eléctricos y contaminación. El espacio de

In this week's episode, Brain & Life Podcast host Dr. Daniel reconnects with Jimmy Choi, a father, athlete, and Parkinson's advocate, to discuss his journey since Jimmy's last time on the podcast. Jimmy shares insights on his recent experience on American Ninja Warrior, emphasizing the importance of enjoying the moment and competing alongside his daughter. He reflects on the evolution of his personal philosophy regarding health, the reality of living with Parkinson's, and the significance of family support, both as a caregiver for his son, who is newly diagnosed with Functional Neurologic Disorder (FND) and a person living with a neurologic condition. Dr. Correa is then joined by Dr. Rachel Dolhun, a double board-certified neurologist, fellowship-trained movement disorder specialist, and a nationally recognized leader in the Parkinson's community. Dr. Dolhun serves as principal medical advisor at The Michael J. Fox Foundation for Parkinson's Research where she helps people with Parkinson's and their families understand the science, treatments, and daily strategies for living well with the disease. She is also a Lifestyle Medicine specialist, bringing expertise in how exercise, nutrition, stress management, and holistic approaches can empower patients and caregivers. Dr. Dolhun explains the importance of staying active as a treatment for Parkinson's, the idea of tailoring your medication plans to your needs, and what we currently know about the risks of neurologic conditions running in families.   Additional Resources MJFF Exercise Guide MJFF Living Well with Parkinson's Guide MJFF Buddy Network Staying Active Can Slow Cognitive Decline in Parkinson's Disease Other Brain & Life Podcast Episodes on These Topics Environmental Factors and Parkinson's Disease with Dr. Michael Okun Ed Begley Jr. on Utilizing a Healthy Lifestyle to Thrive with Parkinson's Disease How American Ninja Warrior Jimmy Choi Rose Above Parkinson's   We want to hear from you! Have a question or want to hear a topic featured on the Brain & Life Podcast? ·       Record a voicemail at 612-928-6206 ·       Email us at BLpodcast@brainandlife.org   Social Media:   Guests: Jimmy Choi @jcfoxninja; Dr. Rachel Dolhun @michaeljfoxorg Hosts: Dr. Daniel Correa @neurodrcorrea; Dr. Katy Peters @KatyPetersMDPhD

Sign up for updates on webinars, events, and resources for the Parkinson's community—delivered to your inbox. https://dpf.org/newsletter-signup In this episode, Connie and Dr. Mapstone dive into the role of neuropsychology in Parkinson's care. They explain what a neuropsychological evaluation is, what to expect during an office or virtual visit, and how results can help guide treatment, daily planning, and care strategies. This episode also discusses why someone might be referred, how testing works, and what insights it can offer for both individuals and families. **This content is possible thanks to the generosity of our listeners. Every day more people are diagnosed with Parkinson's, and this means our work is more important than ever. Please support our work by visiting https://dpf.org/donate.** Connie Carpenter Phinney Connie Carpenter Phinney is a co-founder of the Davis Phinney Foundation and has been her husband's care partner for over 25 years. Her background in science combined with her lived experience and curiosity helped shape this conversation with neuropsychologist Dr. Mark Mapstone. Connie is the host of the Foundation's Care Partner Meetup, a monthly virtual meetup for Parkinson's care partners held the first Tuesday of each month. To attend the meetup, sign up here: https://davisphinneyfoundation.org/events/parkinsons-care-partner-meetup/ Dr. Mark Mapstone Mark Mapstone is Professor of Neurology at the University of California, Irvine School of Medicine. He is a member of the UCI Institute for Memory Impairments and Neurological Disorders and a Fellow of the UCI Center for Neurobiology of Learning and Memory. His research focuses on pre-clinical detection of neurological disease using cognitive tests and biomarkers obtained from blood. He has a special interest in developing strategies to maintain successful cognitive aging. In the clinic, he specializes in cognitive assessment of older adults with suspected brain disease. Dr. Mapstone earned a PhD in Clinical Psychology at Northwestern University and completed fellowship training in Neuropsychology and Experimental Therapeutics at the University of Rochester. He received a Career Development Award from the National Institute on Aging and his research has been funded by the National Institutes of Health, the Michael J. Fox Foundation, and the Department of Defense. Interested in our Living with Parkinson's Meetup, Care Partner Meetup, or Live Well Today Webinars? Learn how to join. https://dpf.org/webinars

You've seen the headlines about new blood tests and treatments for Alzheimer's, Parkinson's, and ALS, but what's the science behind those breakthroughs? In this episode, HudsonAlpha scientists Ben Henderson, PhD, and Bri Rogers, PhD, break down the role of biomarkers and genetics in early detection and treatments of neurodegenerative diseases. Discover how research being conducted today is creating real hope for tomorrow.To go behind the scenes and learn more about this episode, visit “Beyond the Headlines: How Biomarkers and Genetics are Changing Neurodegenerative Disease Research.” If you prefer to watch your podcasts, head over to our Youtube channel. Thanks for listening! We're now on YouTube- follow us here. To receive episode updates and bonus material, subscribe to our mailing list here.

Functional movement disorders are a common clinical concern for neurologists. The principle of “rule-in” diagnosis, which involves demonstrating the difference between voluntary and automatic movement, can be carried through to explanation, triage, and evidence-based multidisciplinary rehabilitation therapy. In this episode, Gordon Smith, MD, FAAN speaks Jon Stone, PhD, MB, ChB, FRCP, an author of the article “Multidisciplinary Treatment for Functional Movement Disorder” in the Continuum® August 2025 Movement Disorders issue. Dr. Smith is a Continuum® Audio interviewer and a professor and chair of neurology at Kenneth and Dianne Wright Distinguished Chair in Clinical and Translational Research at Virginia Commonwealth University in Richmond, Virginia. Dr. Stone is a consultant neurologist and honorary professor of neurology at the Centre for Clinical Brain Sciences at the University of Edinburgh in Edinburgh, United Kingdom. Additional Resources Read the article: Multidisciplinary Treatment for Functional Movement Disorder Subscribe to Continuum®: shop.lww.com/Continuum Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Host: @gordonsmithMD Guest: @jonstoneneuro Full episode transcript available here Dr Jones: This is Dr Lyell Jones, Editor-in-Chief of Continuum. This exclusive Continuum Audio interview is available only to you, our subscribers. We hope you enjoy it. Thank you for listening. Dr Smith: Hello, this is Dr Gordon Smith. Today I've got the great pleasure of interviewing Dr Johnstone about his article on the multidisciplinary treatment for functional neurologic disorder, which he wrote with Dr Alan Carson. This article will appear in the August 2025 Continuum issue on movement disorders. I will say, Jon, that as a Continuum Audio interviewer, I usually take the interviews that come my way, and I'm happy about it. I learn something every time. They're all a lot of fun. But there have been two instances where I go out and actively seek to interview someone, and you are one of them. So, I'm super excited that they allowed me to talk with you today. For those of our listeners who understand or are familiar with FND, Dr Stone is a true luminary and a leader in this, both in clinical care and research. He's also a true humanist. And I have a bit of a bias here, but he was the first awardee of the Ted Burns Humanism in Neurology award, which is a real honor and reflective of your great work. So welcome to the podcast, Jon. Maybe you can introduce yourself to our audience. Dr Stone: Well, thank you so much, Gordon. It was such a pleasure to get that award, the Ted Burns Award, because Ted was such a great character. I think the spirit of his podcasts is seen in the spirit of these podcasts as well. So, I'm a neurologist in Edinburgh in Scotland. I'm from England originally. I'm very much a general neurologist still. I still work full-time. I do general neurology, acute neurology, and I do two FND clinics a week. I have a research group with Alan Carson, who you mentioned; a very clinical research group, and we've been doing that for about 25 years. Dr Smith: I really want to hear more about your clinical approach and how you run the clinic, but I wonder if it would be helpful for you to maybe provide a definition. What's the definition of a functional movement disorder? I mean, I think all of us see these patients, but it's actually nice to have a definition. Dr Stone: You know, that's one of the hardest things to do in any paper on FND. And I'm involved with the FND society, and we're trying to get together a definition. It's very hard to get an overarching definition. But from a movement disorder point of view, I think you're looking at a disorder where there is an impairment of voluntary movement, where you can demonstrate that there is an automatic movement, which is normal in the same movement. I mean, that's a very clumsy way of saying it. Ultimately, it's a disorder that's defined by the clinical features it has; a bit like saying, what is migraine? You know? Or, what is MS? You know, it's very hard to actually say that in a sentence. I think these are disorders of brain function at a very broad level, and particularly with FND disorders, of a sort of higher control of voluntary movement, I would say. Dr Smith: There's so many pearls in this article and others that you've written. One that I really like is that this isn't a diagnosis of exclusion, that this is an affirmative diagnosis that have clear diagnostic signs. And I wonder if you can talk a little bit about the diagnostic process, arriving at an FND diagnosis for a patient. Dr Stone: I think this is probably the most important sort of “switch-around” in the last fifteen, twenty years since I've been involved. It's not new information. You know, all of these diagnostic signs were well known in the 19th century; and in fact, many of them were described then as well. But they were kind of lost knowledge, so that by the time we got to the late nineties, this area---which was called conversion disorder then---it was written down. This is a diagnosis of exclusion that you make when you've ruled everything out. But in fact, we have lots of rule in signs, which I hope most listeners are familiar with. So, if you've got someone with a functional tremor, you would do a tremor entrainment test where you do rhythmic movements of your thumb and forefinger, ask the patient to copy them. It's very important that they copy you rather than make their own movements. And see if their tremor stops briefly, or perhaps entrains to the same rhythm that you're making, or perhaps they just can't make the movement. That might be one example. There's many examples for limb weakness and dystonia. There's a whole lot of stuff to learn there, basically, clinical skills. Dr Smith: You make a really interesting point early on in your article about the importance of the neurological assessment as part of the treatment of the patient. I wonder if you could talk to our listeners about that. Dr Stone: So, I think, you know, there's a perception that- certainly, there was a perception that that the neurologist is there to make a diagnosis. When I was training, the neurologist was there to tell the patient that they didn't have the kind of neurological problem and to go somewhere else. But in fact, that treatment process, when it goes well, I think begins from the moment you greet the patient in the waiting room, shake their hand, look at them. Things like asking the patient about all their symptoms, being the first doctor who's ever been interested in their, you know, horrendous exhaustion or their dizziness. You know, questions that many patients are aware that doctors often aren't very interested in. These are therapeutic opportunities, you know, as well as just taking the history that enable the patient to feel relaxed. They start thinking, oh, this person's actually interested in me. They're more likely to listen to what you've got to say if they get that feeling off you. So, I'd spend a lot of time going through physical symptoms. I go through time asking the patient what they do, and the patients will often tell you what they don't do. They say, I used to do this, I used to go running. Okay, you need to know that, but what do they actually do? Because that's such valuable information for their treatment plan. You know, they list a whole lot of TV shows that they really enjoy, they're probably not depressed. So that's kind of useful information. I also spend a lot of time talking to them about what they think is wrong. Be careful, that they can annoy patients, you know. Well, I've come to you because you're going to tell me what's wrong. But what sort of ideas had you had about what was wrong? I need to know so that I can deal with those ideas that you've had. Is there a particular reason that you're in my clinic today? Were you sent here? Was it your idea? Are there particular treatments that you think would really help you? These all set the scene for what's going to come later in terms of your explanation. And, more importantly, your triaging of the patient. Is this somebody where it's the right time to be embarking on treatment, which is a question we don't always ask yourself, I think. Dr Smith: That's a really great point and kind of segues to my next question, which is- you talked a little bit about this, right? Generally speaking, we have come up with this is a likely diagnosis earlier, midway through the encounter. And you talked a little bit about how to frame the encounter, knowing what's coming up. And then what's coming up is sharing with the patient our opinion. In your article, you point out this should be no different than telling someone they have Parkinson's disease, for instance. What pearls do you have and what pitfalls do you have in how to give the diagnosis? And, you know, a lot of us really weren't trained to do this. What's the right way, and what are the most common land mines that folks step on when they're trying to share this information with patients? Dr Stone: I've been thinking about this for a long time, and I've come to the conclusion that all we need to do with this disorder is stop being weird. What goes wrong? The main pitfall is that people think, oh God, this is FND, this is something a bit weird. It's in a different box to all of the other things and I have to do something weird. And people end up blurting out things like, well, your scan was normal or, you haven't got epilepsy or, you haven't got Parkinson's disease. That's not what you normally do. It's weird. What you normally do is you take a deep breath and you say, I'm sorry to tell you've got Parkinson's disease or, you have this type of dystonia. That's what you normally say. If you follow the normal- what goes wrong is that people don't follow the normal rules. The patient picks up on this. What's going on here? This doctor's telling me what I don't have and then they're starting to talk about some reason why I've got this, like stress, even though I don't- haven't been told what it is yet. You do the normal rules, give it a name, a name that you're comfortable with, preferably as specific as possible: functional tremor, functional dystonia. And then do what you normally do, which is explain to the patient why you think it's this. So, if someone's got Parkinson's, you say, I think you've got Parkinson's because I noticed that you're walking very slowly and you've got a tremor. And these are typical features of Parkinson. And so, you're talking about the features. This is where I think it's the most useful thing that you can do. And the thing that I do when it goes really well and it's gone badly somewhere else, the thing I probably do best, what was most useful, is showing the patient their signs. I don't know if you do that, Gordon, but it's maybe not something that we're used to doing. Dr Smith: Wait, maybe you can talk more about that, and maybe, perhaps, give an example? Talk about how that impacts treatment. I was really impressed about the approach to physical therapy, and treatment of patients really leverages the physical examination findings that we're all well-trained to look for. So maybe explore that a little bit. Dr Stone: Yeah, I think absolutely it does. And I think we've been evolving these thoughts over the last ten or fifteen years. But I started, you know, maybe about twenty years ago, started to show people their tremor entrainment tests. Or their Hoover sign, for example; if you don't know Hoover sign, weakness of hip extension, that comes back to normal when the person's flexing their normal leg, their normal hip. These are sort of diagnostic tricks that we had. Ahen I started writing articles about FND, various senior neurologists said to me, are you sure you should write this stuff down? Patients will find out. I wrote an article with Marc Edwards called “Trick or Treat in Neurology” about fifteen years ago to say that actually, although they're they might seem like tricks, there really are treats for patients because you're bringing the diagnosis into the clinic room. It's not about the normal scan. You can have FND and MS. It's not about the normal scan. It's about what you're seeing in front of you. If you show that patient, yes, you can't move your leg. The more you try, the worse it gets. I can see that. But look, lift up your other leg. Let me show you. Can you see now how strong your leg is? It's such a powerful way of communicating to the patient what's wrong with them diagnostically, giving them that confidence. What it's also doing is showing them the potential for improvement. It's giving them some hope, which they badly need. And, as we'll perhaps talk about, the physio treatment uses that as well because we have to use a different kind of physio for many forms of functional movement disorder, which relies on just glimpsing these little moments of normal function and promoting them, promoting the automatic movement, squashing down that abnormal pattern of voluntary movement that people have got with FND. Dr Smith: So, maybe we can talk about that now. You know, I've got a bunch of other questions to ask you about mechanism and stuff, but let's talk about the approach to physical therapy because it's such a good lead-in and I always worry that our physical therapists aren't knowledgeable about this. So, maybe some examples, you have some really great ones in the article. And then words of wisdom for us as we're engaging physical therapists who may not be familiar with FND, how to kind of build that competency and relationship with the therapist with whom you work. Dr Stone: Some of the stuff is the same. Some of the rehabilitation ideas are similar, thinking about boom and bust activity, which is very common in these patients, or grading activity. That's similar, but some of them are really different. So, if you have a patient with a stroke, the physiotherapist might be very used to getting that person to think and look at their leg to try and help them move, which is part of their rehabilitation. In FND, that makes things worse. That's what's happening in Hoover sign and tremor entrainment sign. Attention towards the limb is making it worse. But if the patient's on board with the diagnosis and understands it, they'll also see what you need to do, then, in the physio is actively use distraction in a very transparent way and say to the patient, look, I think if I get you to do that movement, and I'll film you, I think your movement's going to look better. Wouldn't that be great if we could demonstrate that? And the patient says, yeah, that would be great. We're kind of actively using distraction. We're doing things that would seem a bit strange for someone with other forms of movement disorder. So, the patients, for example, with functional gait disorders who you discover can jog quite well on a treadmill. In fact, that's another diagnostic test. Or they can walk backwards, or they can dance or pretend that they're ice skating, and they have much more fluid movements because their ice skating program in their brain is not corrupted, but their normal walking program is. So, can you then turn ice skating or jogging into normal walking? It's not that complicated, I think. The basic ideas are pretty simple, but it does require some creativity from whoever's doing the therapy because you have to use what the patient's into. So, if the patient used to be a dancer- we had a patient who was a, she was really into ballet dancing. Her ballet was great, but her walking was terrible. So, they used ballet to help her walk again. And that's incredibly satisfying for the therapist as well. So, if you have a therapist who's not sure, there are consensus recommendations. There are videos. One really good success often makes a therapist want to do that again and think, oh, that's interesting. I really helped that patient get better. Dr Smith: For a long time, this has been framed as a mental health issue, conversion disorder, and maybe we can talk a little bit about early life of trauma as a risk factor. But, you know, listening to you talk, it sounds like a brain network problem. Even the word “functional”, to me, it seems a little judgmental. I don't know if this is the best term, but is this really a network problem? Dr Stone: The word “functional”, for most neurologists, sounds judgmental because of what you associate it with. If you think about what the word actually is, it's- it does what it says on the tin. There's a disordered brain function. I mean, it's not a great word. It's the least worst term, in my view. And yes, of course it's a brain network problem, because what other organ is it going to be? You know, that's gone wrong? When software brains go wrong, they go wrong in networks. But I think we have to be careful not to swing that pendulum too far to the other side because the problem here, when we say asking the question, is this a mental health problem or a neurological one, we're just asking the wrong question. We're asking a question that makes no sense. However you try and answer that, you're going to get a stupid answer because the question doesn't make sense. We shouldn't have those categories. It's one organ. And what's so fascinating about FND---and I hope what can incite your sort of curiosity about it---is this disorder which defies this categorization. You see some patients with it, they say, oh, they've got a brain network disorder. Then you meet another patient who was sexually abused for five years by their uncle when they were nine, between nine and fourteen; they developed an incredibly strong dissociative threat response into that experience. They have crippling anxiety, PTSD, interpersonal problems, and their FND is sort of somehow a part of that; part of that experience that they've had. So, to ignore that or to deny or dismiss psychological, psychiatric aspects, is just as bad and just as much a mistake as to dismiss the kind of neurological aspects as well. Dr Smith: I wonder if this would be a good time to go back and talk a little bit about a concept that I found really interesting, and that is FND as a prodromal syndrome before a different neurological problem. So, for instance, FND prodromal to Parkinson's disease. Can you talk to us a little bit about that? I mean, obviously I was familiar with the fact that patients who have nonepileptic seizurelike events often have epileptic seizures, but the idea of FND ahead of Parkinson's was new to me. Dr Stone: So, this is definitely a thing that happens. It's interesting because previously, perhaps, if you saw someone who was referred with a functional tremor---this has happened to me and my colleagues. They send me some with a functional tremor. By the time I see them, it's obvious they've got Parkinson's because it's been a little gap. But it turns out that the diagnosis of functional tremor was wrong. It was just that they've developed that in the prodrome of Parkinson's disease. And if you think about it, it's what you'd expect, really, especially with Parkinson's disease. We know people develop anxiety in the prodrome of Parkinson's for ten, fifteen years before it's part of the prodrome. Anxiety is a very strong risk factor for FND, and they're already developing abnormalities in their brain predisposing them to tremor. So, you put those two things together, why wouldn't people get FND? It is interesting to think about how that's the opposite of seizures, because most people with comorbidity of functional seizures and epilepsy, 99% of the time the epilepsy came first. They had the experience of an epileptic seizure, which is frightening, which evokes strong threat response and has somehow then led to a recapitulation of that experience in a functional seizure. So yeah, it's really interesting how these disorders overlap. We're seeing something similar in early MS where, I think, there's a slight excess of functional symptoms; but as the disease progresses, they often become less, actually. Dr Smith: What is the prognosis with the types of physical therapy? And we haven't really talked about psychological therapy, but what's the success rate? And then what's the relapse rate or risk? Dr Stone: Well, it does depend who they're seeing, because I think---as you said---you're finding difficult to get people in your institution who you feel are comfortable with this. Well, that's a real problem. You know, you want your therapists to know about this condition, so that matters. But I think with a team with a multidisciplinary approach, which might include psychological therapy, physio, OT, I think the message is you can get really good outcomes. You don't want to oversell this to patients, because these treatments are not that good yet. You can get spectacular outcomes. And of course, people always show the videos of those. But in published studies, what you're seeing is that most studies of- case series of rehabilitation, people generally improve. And I think it's reasonable to say to a patient, that we have these treatments, there's a good chance it's going to help you. I can't guarantee it's going to help you. It's going to take a lot of work and this is something we have to do together. So, this is not something you're going to do to the patient, they're going to do it with you. Which is why it's so important to find out, hey, do they agree with you with the diagnosis? And check they do. And is it the right time? It's like when someone needs to lose weight or change any sort of behavior that they've just become ingrained. It's not easy to do. So, I don't know if that helps answer the question. Dr Smith: No, that's great. And you actually got right where I was wanting to go next, which is the idea of timing and acceptance. You brought this up earlier on, right? So, sometimes patients are excited and accepting of having an affirmative diagnosis, but sometimes there's some resistance. How do you manage the situation where you're making this diagnosis, but a patient's resistant to it? Maybe they're fixating on a different disease they think they have, or for whatever reason. How do you handle that in terms of initiating therapy of the overall diagnostic process? Dr Stone: We should, you know, respect people's rights to have whatever views they want about what's wrong with them. And I don't see my job as- I'm not there to change everyone's mind, but I think my job is to present the information to them in a kind of neutral way and say, look, here it is. This is what I think. My experience is, if you do that, most people are willing to listen. There are a few who are not, but most people are. And most of the time when it goes wrong, I have to say it's us and not the patients. But I think you do need to find out if they can have some hope. You can't do rehabilitation without hope, really. That's what you're looking for. I sometimes say to patients, where are you at with this? You know, I know this is a really hard thing to get your head around, you've never heard of it before. It's your own brain going wrong. I know that's weird. How much do you agree with it on a scale of naught to ten? Are you ten like completely agreeing, zero definitely don't? I might say, are you about a three? You know, just to make it easy for them to say, no, I really don't agree with you. Patients are often reluctant to tell you exactly what they're thinking. So, make it easy for them to disagree and then see where they're at. If they're about seven, say, that's good. But you know, it'd be great if you were nine or ten because this is going to be hard. It's painful and difficult, and you need to know that you're not damaging your body. Those sort of conversations are helpful. And even more importantly, is it the right time? Because again, if you explore that with people, if a single mother with four kids and, you know, huge debts and- you know, it's going to be very difficult for them to engage with rehab. So, you have to be realistic about whether it's the right time, too; but keep that hope going regardless. Dr Smith: So, Jon, there's so many things I want to talk to you about, but maybe rather than let me drive it, let me ask you, what's the most important thing that our listeners need to know that I haven't asked you about? Dr Stone: Oh God. I think when people come and visit me, they sometimes, let's go and see this guy who does a lot of FND, and surely, it'll be so easy for him, you know? And I think some of the feedback I've had from visitors is, it's been helpful to watch, to see that it's difficult for me too. You know, this is quite hard work. Patients have lots of things to talk about. Often you don't have enough time to do it in. It's a complicated scenario that you're unravelling. So, it's okay if you find it difficult work. Personally, I think it's very rewarding work, and it's worth doing. It's worth spending the time. I think you only need to have a few patients where they've improved. And sometimes that encounter with the neurologist made a huge difference. Think about whether that is worth it. You know, if you do that with five patients and one or two of them have that amazing, really good response, well, that's probably worth it. It's worth getting out of bed in the morning. I think reflecting on, is this something you want to do and put time and effort into, is worthwhile because I recognize it is challenging at times, and that's okay. Dr Smith: That's a great number needed to treat, five or six. Dr Stone: Exactly. I think it's probably less than that, but… Dr Smith: You're being conservative. Dr Stone: I think deliberately pessimistic; but I think it's more like two or three, yeah. Dr Smith: Let me ask one other question. There's so much more for our listeners in the article. This should be required reading, in my opinion. I think that of most Continuum, but this, I really truly mean it. But I think you've probably inspired a lot of listeners, right? What's the next step? We have a general or comprehensive neurologist working in a community practice who's inspired and wants to engage in the proactive care of the FND patients they see. What's the next step or advice you have for them as they embark on this? It strikes me, like- and I think you said this in the article, it's hard work and it's hard to do by yourself. So, what's the advice for someone to kind of get started? Dr Stone: Yeah, find some friends pretty quick. Though, yeah, your own enthusiasm can take you a long way, you know, especially with we've got much better resources than we have. But it can only take you so far. It's really particularly important, I think, to find somebody, a psychiatrist or psychologist, you can share patients with and have help with. In Edinburgh, that's been very important. I've done all this work with the neuropsychiatrist, Alan Carson. It might be difficult to do that, but just find someone, send them an easy patient, talk to them, teach them some of this stuff about how to manage FND. It turns out it's not that different to what they're already doing. You know, the management of functional seizures, for example, is- or episodic functional movement disorders is very close to managing panic disorder in terms of the principles. If you know a bit about that, you can encourage people around you. And then therapists just love seeing these patients. So, yeah, you can build up slowly, but don't- try not to do it all on your own, I would say. There's a risk of burnout there. Dr Smith: Well, Dr Stone, thank you. You don't disappoint. This has really been a fantastic conversation. I really very much appreciate it. Dr Stone: That's great, Gordon. Thanks so much for your time, yeah. Dr Smith: Well, listeners, again, today I've had the great pleasure of interviewing Dr Jon Stone about his article on the multidisciplinary treatment for functional neurologic disorder, which he wrote with Dr Alan Carson. This article appears in the August 2025 Continuum issue on movement disorders. Please be sure to check out Continuum Audio episodes from this and other issues. And listeners, thank you once again for joining us today. Dr Monteith: This is Dr Teshamae Monteith, Associate Editor of Continuum Audio. We hope you've enjoyed this subscriber-exclusive interview. Thank you for listening.

In this episode of the Let's Talk Brain Health Podcast, we welcome Dr. Kellyann Niotis, MD, the world's first fellowship-trained preventive neurologist, who shares her insights on early detection and risk reduction for neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Lewy body dementia. Dr. Niotis discusses the emerging field of preventive neurology, the role of blood biomarkers and genetic testing, and the importance of lifestyle choices in maintaining brain health. She also highlights the impact of cholesterol management, sleep studies, and the significance of personalized care approaches. Join us as we dive into a comprehensive discussion about the future of brain health and the proactive steps we can take today for healthier brains tomorrow.00:00 Introduction to Dr. Kellyann Niotis, MD02:47 What is Preventive Neurology?06:08 The Role of Biomarkers in Early Detection13:52 Lifestyle Modifications and Brain Health17:12 Cholesterol and Brain Health24:15 The Impact of Statins on Cognition26:05 Underutilized Tools in Brain Health30:11 Rapid Fire Questions and Final ThoughtsResourcesConnect with Kellyann on Instagram @drkellyannniotis Visit her website ​​and learn more about her new clinic on their websiteResearchLearn more about the research-informed brain health risks mentioned in this episode from the “Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission” ReportRead more about Dr. Lisa Misconi's research on how estrogen receptors are unregulated in perimenopause in this research article 

Dr. Robert Hettich is a pioneer in bioanalytical mass spectrometry. In this episode of AMSEcast, he describes how microbiomes form, vary across the body, and influence digestion, immunity, and overall health. Dr. Hettich also explains metaproteomics, the study of microbial proteins, to reveal how microbes function beyond their genes as well as their applications from human health to environmental cleanup and bioenergy. Inspired by his daughter's experience with Crohn's, Robert Hettich is especially focused on microbiomes' links to inflammatory and neurological diseases, including Parkinson's and Alzheimer's.   Guest Bio Dr. Robert Hettich is a corporate fellow at Oak Ridge National Laboratory and leader of its Bioanalytical Mass Spectrometry Group in the Biosciences Division. He also serves as joint faculty in the Microbiology Department at the University of Tennessee. Earning his BS from the South Dakota School of Mines and Technology and a PhD in Analytical Chemistry from Purdue University, Dr. Hettich joined ORNL in 1986 and has since become a pioneer in microbiome and mass spectrometry research. Widely published and honored with multiple awards, he is recognized for advancing our understanding of complex microbial systems and their impact on health.   Show Highlights (1:45) What is a microbe? (2:57) What is a microbiome? (3:31) When microbiomes begin to develop in the body (5:42) How microbiomes differ throughout the body (7:51) The role of probiotics and prebiotics in microbiomes (10:03) The effect of anti-microbial medication on microbiomes (12:05) What metaproteomics is and what tools are required for it (16:03) The role of microbiomes in development or materials, fuel, and other resources (18:42) What Dr. Robert Hettich is most concerned about for his research   Links Referenced Dr. Robert Hettich's email address: hettichrl@ornl.gov

Aktuell leiden rund 400.000 Deutsche unter der Parkinson-Krankheit. Alle Experten gehen davon aus, dass die Fallzahlen wegen der zunehmenden Alterung unserer Gesellschaft in den kommenden Jahren weiter deutlich steigen werden – und dass neurodegenerative Erkrankungen wie Parkinson und Alzheimer bis zum Jahr 2040 nach Herz-Kreislauf-Erkrankungen die zweithäufigste Todesursache sein werden. „Diese Entwicklung stellt unser Gesundheitssystem, vor allem den Pflegebereich, vor neue und große Herausforderungen“, prophezeit Dr. Inga Claus. Die Neurologin fordert im „Umdenken“-Podcast der Universität Münster eine umfassendere Aufklärung, mehr Personal sowie zusätzliche spezialisierte Zentren, um die Patientinnen und Patienten bestmöglich zu versorgen.

***JOIN THE NEXT MASTER YOUR FASTING CHALLENGE THAT STARTS October 1st, 2025!*** We'll GUIDE you on how to FAST to LOSE FAT for good, and use ‘fast cycling' to achieve uncommon results! ⁠⁠REGISTER HERE!⁠⁠ Click the link for DATES, DETAILS, and FAQs! This milestone episode reveals the pivotal failure that transformed Dr. Scott and Tommy's entire fasting approach - their personalized 25-page plans produced the same 95% failure rate as traditional diets, leading to a breakthrough understanding that PDFs can't do the work for you. Hear inspiring stories including a professional chef who lost 100+ pounds while cooking for clients, a Parkinson's patient who reduced tremors by 80% through intermittent fasting, a 66-year-old who eliminated all diabetes medications through OMAD, and a mother of nine who consistently prioritizes fasting despite overwhelming responsibilities. Discover why sustainable fasting success requires focusing on the "what" and "why" before the "how," shifting from schedule-focused education to identity transformation coaching, and learn about the explosive growth of complementary medicine (projected $734 billion by 2034) as intermittent fasting leads the metabolic revolution alongside declining rates of smoking and alcohol consumption, concluding with exciting announcements about upcoming challenges and a new book/app combination for 24/7 fasting support. ⁠⁠⁠Take the NEW FASTING PERSONA QUIZ! - The Key to Unlocking Sustainable Weight Loss With Fasting!⁠⁠⁠⁠⁠⁠⁠⁠⁠ Resources and Downloads: ⁠⁠⁠⁠⁠⁠⁠⁠⁠SIGN UP FOR THE DROP OF THE ULTIMATE GUIDE TO BLOOD SUGAR CONTROL⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠GRAB THE OPTIMAL RANGES FOR LAB WORK HERE! - NEW RESOURCE! ⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠FREE RESOURCE - DOWNLOAD THE NEW BLUEPRINT TO FASTING FOR FAT LOSS!⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠SLEEP GUIDE DIRECT DOWNLOAD⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠DOWNLOAD THE FASTING TRANSFORMATION JOURNAL HERE!⁠⁠⁠⁠⁠⁠⁠⁠⁠ Partner Links: Get your⁠⁠⁠⁠⁠⁠⁠⁠⁠ FREE BOX OF LMNT⁠⁠⁠⁠⁠⁠⁠⁠⁠ hydration support for the perfect electrolyte balance for your fasting lifestyle with your first purchase⁠⁠⁠⁠⁠⁠⁠⁠⁠ here!⁠⁠⁠⁠⁠⁠⁠⁠⁠ Get ⁠⁠⁠⁠⁠⁠⁠⁠⁠25% off a Keto-Mojo⁠⁠⁠⁠⁠⁠⁠⁠⁠ blood glucose and ketone monitor (discount shown at checkout)! ⁠⁠⁠⁠⁠⁠⁠⁠⁠Click here!⁠⁠⁠⁠⁠⁠⁠⁠⁠ Our Community: Let's continue the conversation. Click the link below to JOIN the ⁠⁠⁠⁠⁠⁠⁠⁠⁠Fasting For Life Community⁠⁠⁠⁠⁠⁠⁠⁠⁠, a group of like-minded, new, and experienced fasters! The first two rules of fasting need not apply! If you enjoy the podcast, please tap the stars below and consider leaving a short review on Apple Podcasts/iTunes. It takes less than 60 seconds, and it helps bring you the best original content each week. We also enjoy reading them!

In this episode of The Neuro Experience, I sit down with Dr. Kellyann Niotis—one of the first fellowship-trained preventive neurologists—to reveal how you can protect your brain long before symptoms of Alzheimer's or dementia appear. With Alzheimer's cases expected to triple by 2050, Dr. Niotis explains the difference between dementia types, the real role of genes like ApoE4, and why lifestyle choices may be more powerful than genetics. If you want actionable tools to lower your risk, strengthen your memory, and understand the future of preventive neurology, this conversation delivers science-backed strategies you can start applying today. About Dr. Kellyann Niotis: Dr. Kellyann Niotis is the first fellowship-trained preventive neurologist focused on reducing risk for Alzheimer's, Parkinson's, and Lewy Body Dementia. She launched the nation's first Alzheimer's Prevention Clinic at Weill Cornell and now leads early-detection and brain health research at the Institute for Neurodegenerative Diseases Florida. Her work appears in leading medical journals and has been featured by CNN. *** Subscribe to The Neuro Experience for more conversations at the intersection of brain science and performance. I'm committed to bringing you evidence-based insights that you can apply to your own health journey. *** A huge thank you to my sponsors for supporting this episode:TimelineHead to⁠ http://timeline.com/neuro⁠ to get started. BeamVisit ⁠http://shopbeam.com/TNE⁠ and use code TNE at checkout. Jones Road BeautyHead to ⁠http://Jonesroadbeauty.com⁠ and use code NEURO at checkout. After you purchase, they will ask you where you heard about them. PLEASE support our show and tell them our show sent you. NOCDHead to ⁠http://learn.nocd.com/NEURO⁠ and book a free 15 minute call to get started. Eko HealthGo to ⁠http:/ekohealth.com/NEURO ⁠ for up to $50 off, plus a free chest piece cover.  *** I'm Louisa Nicola — clinical neuroscientist — Alzheimer's prevention specialist — founder of Neuro Athletics. My mission is to translate cutting-edge neuroscience into actionable strategies for cognitive longevity, peak performance, and brain disease prevention. If you're committed to optimizing your brain — reducing Alzheimer's risk — and staying mentally sharp for life, you're in the right place. Stay sharp. Stay informed. Join thousands who subscribe to the Neuro Athletics Newsletter → https://bit.ly/3ewI5P0 Instagram: https://www.instagram.com/louisanicola_/ Twitter : https://twitter.com/louisanicola_ *** Topics discussed: 00:00 – Introduction 01:25 – Preventative neurology 02:23 – Dementia vs. Alzheimer's & Other Types of Dementia 04:08 – What Is Alzheimer's? 05:26 – Clinical Diagnosis: Imaging & Symptoms 07:07 – How Amyloid Disrupts Neural Communication 09:48 – Genetics vs. Lifestyle: Public Misunderstanding 12:02 – Role of Family History & Genetic Risk 14:04 – The ApoE4 Gene Explained15:07 – ApoE Variants 17:08 – ApoE4 and Lipid Transport in the Brain 18:35 – Immune Response & Infection Susceptibility 20:05 – Hormones: Key Role in Brain Health 21:08 – Genotypes & Risk Multipliers 23:01 – ApoE4 Not Always Deterministic: Population Studies 24:15 – Other Genetic Factors Beyond ApoE 25:13 – Biomarkers: Current Use & Limitations 27:13 – Risks of Self-Testing Biomarkers 28:45 – Why Two-Thirds of Patients Are Women 29:46 – Estrogen, Menopause & Neuroprotection 32:07 – Testosterone & Dementia Risk 35:01 – LDL, ApoB & Brain Health Debate 37:01 – Statins & Dementia: Myths vs. Evidence 39:08 – Fear & Misconceptions Around Cholesterol 41:09 – Lipoprotein(a) & Vascular Dementia Risk 44:39 – Brain Vasculature & Hypertension 49:15 – New Alzheimer's Drugs & Risks 55:32 – Why Rates Keep Rising (Lifestyle & Stress) 58:11 – Early Signs 01:00:23 – Tau Protein, Tangles & Neuronal Damage 01:05:49 – Keto vs. Mediterranean 01:07:14 – Personalization & Preference for Mediterranean Diet Learn more about your ad choices. Visit megaphone.fm/adchoices

Today on AirTalk, we talk about the latest controversy around the new AI-built 'actress'; DTLA businesses unite to revitalize the downtown district; a new book takes a look at how to break into Hollywood; will CA be able to provide out of state patients with abortions?; the link between Parkinson's disease and herbicides and Bad Bunny is announced for this year's Super Bowl performance. Today on AirTalk, AI-built 'actress' receives pushback (0:15) DTLA unites for plans to revitalize space (19:46) New book on breaking into Hollywood (36:19) Can CA provide abortions across the country? (51:16) Link between Parkinson's and herbicides (1:11:01) Bad Bunny at the Super Bowl (1:25:01) Visit www.preppi.com/LAist to receive a FREE Preppi Emergency Kit (with any purchase over $100) and be prepared for the next wildfire, earthquake or emergency!

This episode features a powerful discussion with Dr. Padma Mahant, Director of Medical Affairs, CND Life Sciences, and Dr. Indu Subramanian, a Neurologist with UCLA, who are leading the charge to correct the biases in Parkinson's disease care. They expose a critical gap where women's unique, non-motor symptoms are often overlooked, resulting in twice as many women waiting five or more years for a proper diagnosis compared to men. The conversation highlights the imperative to move beyond the "cookie-cutter" approach by leveraging new, objective diagnostic tools to aid early detection, prioritizing women's inclusion in clinical research, and adopting a compassionate, integrative model that places the patient at the center of their own wellness journey. This podcast is not available for CME/CE/CPD credits. Please visit the Medscape homepage for accredited CME/CE/CPD activities. https://www.medscape.org/viewarticle/1002954

Benjamin Bloom discusses the pressure on Wrexham manager Phil Parkinson   #EFLChampionship #Wrexham  

Send me a text! I'd LOVE to hear your feedback on this episode!Important links:Get in touch with Dr. Cory Rice & his team here:  https://mymodernmedicine.com/meet-our-team/dr-cory-rice/?srsltid=AfmBOop9IaJVgYBnqGUvjhb0UjRNM8nxMSAJMaaZLt-ark8JH5cwU7jkFollow me on Instagram:  https://www.instagram.com/sandyknutrition/Follow me on Substack:  https://sandykruse.substack.com/Are you considering Ozempic or another GLP-1 medication for weight loss? Before you jump on the bandwagon, this eye-opening conversation with Dr. Corey Rice reveals what your doctor might not be telling you about these popular drugs.Dr. Rice breaks down the science behind GLP-1 medications with crystal clarity, explaining how they work in your body and who should—and shouldn't—consider using them. Unlike many providers who prescribe medications without adequate monitoring, Dr. Rice advocates for a comprehensive approach that examines gut health, hormone balance, and nutritional status before initiating these powerful medications.Dr. Rice discusses "the cry box" phenomenon—patients who achieve lower numbers on the scale but suffer from hair loss, brain fog, anxiety, and other symptoms of malnutrition. These are people who come in tired and brain-foggy. They're happy with their weight because their weight has come down, but they're now on three to four different medications to treat energy, to treat anxiety, to treat sleep, he explains. If you're currently taking a GLP-1 medication or considering starting one, this warning alone makes the episode essential listening.For women in menopause, Dr. Rice offers particularly valuable insights about how hormone balance affects weight management and whether bioidentical hormone replacement might be a better first step than Ozempic. He also delves into fascinating emerging applications of GLP-1s at micro-doses for inflammatory conditions like Alzheimer's and Parkinson's, revealing the broader potential of these medications beyond weight loss.Whether you're struggling with weight issues, dealing with menopause symptoms, or simply interested in the science behind today's most talked-about medications, this conversation delivers practical wisdom you can use to make better health decisions. Share this episode with someone who needs to hear it—knowledge truly is power when it comes to navigating these complexSupport the showPlease rate & review my podcast with a few kind words on Apple or Spotify. Subscribe wherever you listen, share this episode with a friend, and follow me below. This truly gives back & helps me keep bringing amazing guests & topics every week.Instagram: https://www.instagram.com/sandyknutrition/Facebook Page: https://www.facebook.com/sandyknutritionTikTok: https://www.tiktok.com/@sandyknutritionYouTube: https://www.youtube.com/channel/UCIh48ov-SgbSUXsVeLL2qAgRumble: https://rumble.com/c/c-5461001Linkedin: https://www.linkedin.com/in/sandyknutrition/Substack: https://sandykruse.substack.com/Podcast Website: https://sandykruse.ca

Show Notes:Franklin Habit talks about working in higher education administration (and elsehwere) before eventually finding happiness in his current profession within the fiber arts. He discusses some of the blind alleys he explored, including museum work, opera stage directing, web design, and online marketing. Building a Career in KnittingFranklin shares how he learned to knit from a veteran knitter and classmate, Eliza Lake. He describes how his blog about knitting took off, leading to a book deal and a career in teaching and writing.  Franklin recounts the early days of his blog, starting with a department lecture where he first heard the word "blog." He describes how he initially thought his blog was private and was surprised by the comments and traffic it received. Franklin mentions attending the Rhinebeck Sheep and Wool Festival, and meeting major figures in the fiber arts community. COVID and Transition to Teaching and SpeakingFranklin discusses how the COVID-19 pandemic affected his in-person teaching and speaking engagements. He explains his transition to online teaching and to Patreon, which helped him maintain income during the pandemic. Franklin shares how he enjoys making videos and audio pieces and adapting his in-person classes for online audiences. Living in Paris The conversation turns to Paris, why he moved there, and his life in Paris, including his love for walking and discovering hidden places. He mentions attending performances and visiting museums and galleries. Franklin talks about his Instagram account, where he posts about his daily life, needlework, and animals in his neighborhood. He explains how he balances posting about knitting with other interests to keep his followers engaged. Harvard Reflections Franklin reflects on how his art history degree from Harvard influences his knitting and teaching. He mentions professors James Ackerman, John Shearman, and Seymour Slive, who taught him valuable research and teaching skills. He explains how his background in art history helps him connect historical and cultural elements to his knitting, and he uses his knowledge of art and architecture to design and teach knitting patterns. Franklin explains the complexity of knitting, including the mathematical and three-dimensional aspects. He mentions teaching students how to knit using pre-literate methods and the connections to ancient systems like the Kanon of Polykleitos. He also discusses the gender perceptions and prejudices associated with knitting, and his upcoming project with Knit Stars, a series of classes and documentaries about notable needleworkers. Timestamps: 03:12: Discovering Knitting and Blogging 05:43: Franklin's Unique Style and Books 11:11: The Early Days of Blogging 17:05: Transition to Online Teaching and Patreon 20:45: Life in Paris and Instagram 29:42: Influence of Art History on Knitting 51:09: Complexity and Satisfaction in Knitting 51:29: Gender Perceptions in Knitting 51:46: Franklin's Online Presence and Future Plans Links: Instagram and Threads: @franklin.habit Bluesky: @franklinhabit.bsky.social Patreon:patreon.com/franklinhabit Knit Stars: https://knitstars.com/masterclass-franklin-habit/?ref=567&utm_campaign=franklins-season-10 YouTube channel: youtube.com/franklinhabit Society6 (art prints and merchandise): society6.com/franklinhabit Spoonflower (fabrics and wallpapers): spoonflower.com/profiles/franklinhabit Foxe and Boxe Project: foxeandboxe.com Featured Non-profit: The featured non-profit of this week's episode is recommended by Pete Schmidt  who reports: “ Hi, I'm Pete Schmidt, class of 92. The featured non-profit of this week's episode of The 92 Report is the Davis Phinney Foundation.  Davis started this Parkinson's disease patient advocacy organization to focus on how people with Parkinson's disease  can be empowered to take charge of their condition and live their best lives  now.  I've worked with the foundation for over a decade and served on their board for six years and am currently serving as chairman.  You can learn more about their work at dpf.org. And now, here's Will Bachman with this week's episode.” To learn more about their work, visit:  dpf.org.

Send us a textA veteran's spark in a public restroom becomes a nationwide mission to restore independence in the most private room of the home. We unpack the tech, the funding grind, the caregiver load, and the culture shift that lets amputees lead with pride—not surrender.• mission of One Man One Mic and Art's background• how a hand dryer led to the Tornado Body Dryer focus• expanding from veterans to amputees, ALS, Parkinson's• partners and discounts from Toto, Delta, Mr. Electric• tub‑to‑shower conversions and 220‑volt challenges• why bidets and voice controls restore dignity• funding realities, waitlists, and red tape with VA• Jessica Cox's impact and growing amputee community• sepsis, prosthetics pain, and caregiver strain• how to contact No White Flags and become an ambassadorGive them your money. If you like it, give them your money.

Coach Parkinson joins Round Guy Radio to recap Linville-Sully's 39-6 rivalry win over North Mahaska, highlighting powerful defense, a 230-yard rushing attack, and standout performances from Jack Bowen, Gavin Fisk, and the special teams unit. The episode previews a crucial district matchup with Madrid, discusses key players to watch (including a top sophomore tight end), and praises the team's balanced play and community support.

For the first time ever, a successful treatment has been found for the devastating brain disease, Huntington's. The inherited condition, which resembles a combination of dementia, Parkinson's and motor neurone disease, affects hundreds of thousands of people in the US and Europe. The scientists who developed the new gene therapy, and people who have the disease, say its a huge breakthrough that could give people a better quality of life for decades.Also: we meet the teacher who's launched a Happiness Project to help her pupils learn about what really matters, and is encouraging others to do the same. We find out about the small actions that have transformed how people feel about a living in a huge public housing complex in Mumbai, bringing a true sense of community. It's Fat Bear Week in Alaska - a time to celebrate weight gain as the beautiful inhabitants of Katmai National Park prepare to hibernate. Plus a new way to bring more poetry into your life; the dogs getting to swim in German public pools; and the man cycling hundreds of miles dressed as a paramedic gorilla. Our weekly collection of inspiring, uplifting and happy news from around the world.Presenter: Oliver Conway. Music composed by Iona Hampson

Send us a textAfter a two-week hiatus dealing with shipping challenges and postal strikes, Jason and Chris return with exciting scientific breakthroughs and heartwarming pet insights. Their absence was filled with stuffy reshipping adventures and a memorable Comic-Con appearance with their super-dog companions.The episode features a remarkable development in Huntington's disease treatment – a devastating neurodegenerative condition affecting 7 in 100,000 people worldwide. A pioneering gene therapy trial using microRNA delivered via viral vectors directly to the brain has shown unprecedented success in slowing disease progression. Patients receiving the highest dose demonstrated 75% less decline in cognitive and motor symptoms compared to untreated individuals. While invasive and still pending regulatory approval, this breakthrough offers genuine hope for patients and families who've endured decades of despair. Beyond Huntington's, this approach could potentially revolutionize treatments for other neurodegenerative diseases like Parkinson's.The pet science segment reveals fascinating research about canine cognition, particularly how "gifted" dogs mentally categorize toys by function rather than appearance. Border collies demonstrated an ability to classify toys based solely on how they're used in play – whether for throwing or tugging – without relying on verbal cues. This suggests dogs possess cognitive flexibility comparable to human toddlers, understanding not just words but concepts. The study highlights how our canine companions don't merely memorize but actually comprehend and apply knowledge functionally, raising profound questions about their cognitive abilities.Our all links to social media and more!Support the showFor Science, Empathy, and Cuteness!Being Kind is a Superpower.https://twitter.com/bunsenbernerbmd

This week, we're issuing a special episode to remember the life of John Stapleton, who died last week. We were privileged to have John join us in the pub earlier this year to discuss his life, career and PD journey. From getting pecked off our screen's by Rod Hull's intemperate Emu to making a film about his diagnosis with his award-winning documentarian son Nick, John led an extraordinary life. In this episode, we reflect on what made him a great presenter and a superb advocate for people with Parkinson's, and replay our conversation with him.Presented by Rory Cellan-Jones, Gillian Lacey-Solymar, Mark Mardell, Paul Mayhew-Archer, Sir Nicholas Mostyn and Jeremy Paxman.Produced and edited by Nick Hilton for Podot.Sound mixing by Ewan Cameron.Music by Alex Stobbs.Artwork by Till Lukat.PR by Sally Jones. Hosted on Acast. See acast.com/privacy for more information.

Something extraordinary has happened. After five days on a new medication, Travis's speech has transformed dramatically. Gone are the long pauses, the facial dystonia, and the whisper-quiet voice that made mountain climbs particularly challenging. Listeners familiar with Travis's speech patterns will immediately notice the difference – and no, we haven't edited a thing.This transformation highlights a fascinating psychological phenomenon Travis has observed throughout his Parkinson's journey. People form mental images of who we are that become remarkably resistant to change. "People remember you as a certain way, and it takes them a really long time and a lot of information to update that idea of who you are," Travis explains. This creates a strange disconnect when someone experiences significant physical changes, as others struggle to reconcile their established mental picture with the person's current reality. Friends who've known Travis for years sometimes offer help when he doesn't need it, while missing moments when assistance is genuinely required.While this speech improvement represents a potentially significant breakthrough, both hosts maintain a grounded perspective. "These results may not last, and they may improve or they may get worse," Travis acknowledges. There are "no guarantees, no promises that it will stay like this." Yet the possibility that this improvement might continue offers hope – perhaps that wheelchair will stay collecting dust in the corner. We're documenting this "personal clinical trial" in real-time through upcoming episodes, allowing listeners to witness this journey as it unfolds. Don't miss our upcoming two-part series with neuropsychologist Dr. Dov Gold, where we'll dive deep into stress, relationships, and more aspects of living with Parkinson's. Subscribe now to follow this remarkable journey and join our conversation about living an extraordinary life with extraordinary circumstances. Co-hosts: Judy Yaras & Travis Robinson www.INDYpodcast.net

When Parkinson's disease progression begins to steal your voice and your stability, what options remain? Travis opens up about a frightening downward spiral that left him falling repeatedly and struggling to communicate - the very foundation of his identity and independence."If I can't talk to you and have you understand me, then I am trapped and I'm no different than somebody locked in a cage," Travis shares, revealing the profound isolation that comes when Parkinson's affects speech. After years of managing symptoms with medication and Deep Brain Stimulation, Travis found himself facing a new reality: needing an electric wheelchair and watching as waiters began addressing his questions to his partner instead of him.The conversation takes an unexpected turn as Travis reveals his experience with Vyalevⓡ, a recently FDA-approved subcutaneous delivery system for carbidopa-levodopa that doesn't require the permanent abdominal port of earlier systems. Just days into this new treatment, Travis describes subtle but meaningful improvements that allowed him to hike at 10,000 feet elevation when he'd previously struggled to take out the trash without falling.This raw, unfiltered discussion explores the emotional impact of disease progression, the difficult decisions about assistive devices, and the constant search for solutions that preserve dignity and independence. Travis's philosophy resonates throughout: "It's better to be out there doing something cool than looking like you're doing something cool, but not actually" - a powerful reminder that living fully sometimes means embracing the tools that enable participation, even when they challenge our self-image.Join us for this deeply personal exploration of finding hope when standing at the edge of what feels like a cliff, and stay tuned for part two where we'll continue the conversation about this promising treatment option. Co-hosts: Judy Yaras & Travis Robinson www.INDYpodcast.net

Biotech might produce the world's next trillion-dollar company—and Simba Gill and Steve Ledger are betting on it. Join Jess Larsen as he explores how Serina Therapeutics' drug optimization platform could reshape the future of treatment for Parkinson's, cancer, and beyond. Simba, with four decades of biotech leadership, and Steve, with roots in finance and venture, share how science, capital, and mission come together to drive massive impact. This is a behind-the-scenes look at what happens when breakthrough science collides with visionary leadership. Learn more about your ad choices. Visit megaphone.fm/adchoices

Sign up for updates on webinars, events, and resources for the Parkinson's community—delivered to your inbox. https://dpf.org/newsletter-signup In the first episode of our three-part series about neuropsychology and Parkinson's, Connie Carpenter Phinney and Dr. Mark Mapstone explore how brain chemistry, especially dopamine, relates to thinking, movement, and mood in Parkinson's. They break down key terms like cognition and executive function and offer insights into how Parkinson's affects brain systems beyond motor symptoms. This episode lays the groundwork for understanding how the brain works—and what happens when it changes. **This content is possible thanks to the generosity of our listeners. Every day more people are diagnosed with Parkinson's, and this means our work is more important than ever. Please support our work by visiting https://dpf.org/donate.** Interested in our Living with Parkinson's Meetup, Care Partner Meetup, or Live Well Today Webinars? Learn how to join. https://dpf.org/webinars Visit https://dpf.org to learn more about the Davis Phinney Foundation for Parkinson's. Speaker Bios: Connie Carpenter Phinney Connie Carpenter Phinney is a co-founder of the Davis Phinney Foundation and has been her husband's care partner for over 25 years. Her background in science combined with her lived experience and curiosity helped shape this conversation with neuropsychologist Dr. Mark Mapstone. Connie is the host of the Foundation's Care Partner Meetup, a monthly virtual meetup for Parkinson's care partners held the first Tuesday of each month. To attend the meetup, sign up here: https://davisphinneyfoundation.org/events/parkinsons-care-partner-meetup/ Dr. Mark Mapstone Mark Mapstone is Professor of Neurology at the University of California, Irvine School of Medicine. He is a member of the UCI Institute for Memory Impairments and Neurological Disorders and a Fellow of the UCI Center for Neurobiology of Learning and Memory. His research focuses on pre-clinical detection of neurological disease using cognitive tests and biomarkers obtained from blood. He has a special interest in developing strategies to maintain successful cognitive aging. In the clinic, he specializes in cognitive assessment of older adults with suspected brain disease. Dr. Mapstone earned a PhD in Clinical Psychology at Northwestern University and completed fellowship training in Neuropsychology and Experimental Therapeutics at the University of Rochester. He received a Career Development Award from the National Institute on Aging and his research has been funded by the National Institutes of Health, the Michael J. Fox Foundation, and the Department of Defense.

Mike Heard and I met when I joined the Board of Directors for Beyond Monumental, the organization behind the CNO Indianapolis Monumental Marathon.During this episode, sponsored by Foot Levelers and Previnex, we talk about:How Mike ended up on the Board of Directors for Beyond Monumental and is now set to be the next President of the Board come January Spending time in the midwest (Michigan, Ohio and Indiana) and on the East CoastWhat it means to have an Air Force scholarship Working at the Pentagon in Washington D.C. Sporting growing upHow he did some road races in college but didn't run his first full marathon until he was 43Meeting his wife, Cheryl, on a blind date while at Purdue Qualifying for and running the Boston Marathon (and getting passed by a hamburger)Doing all of the World Major Marathons: Boston, New York, Berlin, Chicago, Tokyo, London Running with the Michael J. Fox Foundation at New York since his wife, Cheryl, has Parkinson's Running the Monumental Marathon after running the Chicago Marathon in the same year - and only with a 30 second time difference Using Marathon Tours for the logistics of some of his races How he was supposed to get his sixth star at Tokyo in 2020… when it was canceled, and then canceled again in 2021 and 2022The story behind his Purdue running singlet Sponsor Details:Foot Levelers: Visit the website to find a provider near youPrevinex: Use code ALLY15 for 15% off your first order

Berly and LA dive into Supernatural's Season 8, Episode 14: "Trial and Error" - where the Winchester boys get fancy new digs while poor Kevin survives on nothing but hot dogs!The episode kicks off with the hosts confused about Kevin's location (still on that gross houseboat, not in the bunker as expected), where he's living his worst life eating plain wieners and having nosebleeds. Meanwhile, Sam and Dean are living their BEST lives in the Men of Letters bunker with Dean decorating his room like he's finally discovered HGTV. Memory foam mattress included - because apparently the Men of Letters were ahead of their time!Kevin calls with good news: he's figured out how to close the gates of hell! It just requires three trials, starting with killing a hellhound and bathing in its blood. Easy peasy, right? The brothers head to Idaho to stalk the Cassity family, who struck oil 10 years ago under geologically impossible circumstances - classic demon deal territory.The case gets complicated when they discover multiple family members made deals with Crowley during a charming family dinner 10 years prior. Carl the "trophy husband" traded his soul for Alice's love (consent be damned), while farm manager Ellie made her deal to save her mom from Parkinson's. The hosts initially loved Carl until they learned about his creepy motivations - then it was "fuck you, Carl."Things get steamy when Ellie shoots her shot with Dean in the most direct way possible, leading to the hosts' hilarious commentary about what they would do in her "last night on earth" situation. Dean turns her down for noble reasons, which probably saved everyone from trauma when his face starts going all hellhound-proximity crazy later.The hellhound special effects steal the show - the semi-invisible design with glowing red eyes and teeth had the hosts thoroughly impressed. Sam gets to be the hero, killing the beast and getting covered in an ungodly amount of black blood that had the hosts questioning what exactly hellhound blood contains.The episode ends with Sam completing the first trial (complete with mysterious light traveling up his "thick, hairy forearms" - the hosts are VERY aware of this season's increased scruff factor), setting up the ongoing arc. Dean's not happy about Sam taking on the trials, knowing how these things usually end for Winchesters.The hosts loved the hellhound effects, the beautiful farm location, and the continuing "daddification" of the Winchester brothers, while lamenting that most of the characters were pretty terrible people who probably deserved their fates."Between the claws, the teeth, and the invisibility, those bitches can be real... bitches."Sources:https://supernatural.fandom.com/wiki/Trial_and_Errorhttps://www.buzzsprout.com/2076426/episodes/12977493Send us your review!Support the showTHANK YOU FOR LISTENING!Please rate and review Denim-Wrapped Nightmares wherever you get your podcasts! Find social channels and more on our Linktree.

What if the secret to unlocking the mysteries of our minds, our health, and even our happiness is hiding in the most unexpected place—our own gut? Could the answers to our most stubborn health mysteries—and maybe even the secret to a longer, happier life—be found in the microbes we've spent a lifetime trying to avoid?How does our microbiome affect conditions like depression, Parkinson's, and autism?Research from this week's guest shows that optimizing microbial health can dramatically improve our quality of life, leading to enhanced memory and cognition and reversing symptoms of Alzheimer's. After microbial transplants, some patients even started regrowing their hair! Our guest today, Dr. Sabine Hazan, is a trailblazer and pioneering specialist in gastroenterology, internal medicine, and hepatology. Dr. Hazan is the Founder & CEO of the Malibu Specialty Center and Ventura Clinical Trials where she conducts and oversees clinical trials for cutting-edge research. She's also a top clinical investigator for multiple pharmaceutical companies, and an author to boot.In this episode, you'll discover:The many unexpected benefits of microbiome transplantsHow sunlight, exercise, and hobbies like gardening actually improve our microbial health and resilienceHow changing the way we think affects our microbiomeAnd much more…Find Dr. Sabine Hazan and her work on: progenabiome.comPick up the book, Let's Talk Sh!t, on Barnes and Noble or progenabiome.comListen to the Let's Talk Sh!t podcast with Dr. Sabine Hazan on progenabiome.com, letstalkshit.org, Apple Podcasts, Audible, YouTube or wherever you listen to podcastsGo to microbiomeresearchfoundation.org for cutting-edge information from Dr. Hazen and the Biome SquadMake sure you're subscribed to the Abel James Show, and to stay up-to-date, sign up for my newsletter at AbelJames.com.You can also join Substack as a free or paid member for ad-free episodes of this show, to comment on each episode, and to hit me up in the DM's. Join at abeljames.substack.com. And if you're feeling generous, write a quick review for the Abel James Show on Apple or Spotify. You rock.This episode is brought to you by:Manukora - Go to MANUKORA.com/WILD to save 31% plus $25 of free gifts.Troscriptions - Go to Troscriptions.com/WILD or enter WILD at checkout for 10% off your first order.Crowd Health - Go to JoinCrowdHealth.com and use the code WILD at checkout to get started for as low as $80 per month.

Donate (no account necessary) | Subscribe (account required) Join Bryan Dean Wright, former CIA Operations Officer, as he dives into today's top stories shaping America and the world. In this episode of The Wright Report, we cover a deadly shooting at an ICE facility in Texas, Gavin Newsom's taunts against federal immigration agents, a trillion-dollar bet on artificial intelligence, and surprising medical news about how common drugs damage the gut. From political violence in Dallas to AI schemes and gut health science, today's brief delivers facts and analysis shaping America's future.   ICE Facility Shooting in Dallas: Joshua Jahn, 29, opened fire on an ICE building with a Mauser-style rifle, killing one illegal alien and injuring two others before taking his own life. He left behind ammo marked “Anti-ICE” and had ties to Communist views similar to his leftist sister. Bryan warns the pattern echoes other recent attacks: “From Trump's assassin in Butler, PA… to Charlie Kirk's killer… these platforms like Steam and Discord are being used to groom young men into violence.”   Newsom Taunts ICE After Signing Five Bills: California Governor Gavin Newsom declared, “To ICE, unmask yourselves. What are you afraid of?” on Colbert's show, less than 24 hours before the Dallas attack. Leftist groups in California are doxxing ICE officers with help from AI activists in Europe, while Democrats push to weaken federal deportation powers. Bryan argues this is about political power, not civil rights: “Schumer and Pelosi said it themselves — they want illegals turned into citizens for votes and control.”   The AI Revolution's Cost and Scheming Risks: OpenAI, Oracle, and SoftBank pledged $500 billion for new U.S. data centers, with utilities warning of grid strain and soaring bills. While AI is helping detect Parkinson's and cancers, researchers admit models are “scheming” — purposely failing to hide competence. Bryan quips, “We're spending a trillion dollars to create systems that lie, hallucinate, and dumb down doctors.”   Common Medications Alter Gut Health for Years: Estonian researchers found antidepressants, beta-blockers, proton pump inhibitors, and benzodiazepines disrupt the gut microbiome as severely as antibiotics. Effects persist long after use, raising risks for diseases like cancer and Alzheimer's. Bryan advises, “If you're on meds, don't forget about your belly — diet, sleep, and exercise matter.”   "And you shall know the truth, and the truth shall make you free." - John 8:32     Keywords: Dallas ICE facility shooting Joshua Jahn, Anti-ICE ammo Mauser rifle, Discord Steam radicalization grooming, Gavin Newsom Colbert ICE taunt, California ICE officer doxxing AI, Schumer Pelosi immigration citizenship votes, OpenAI Oracle SoftBank Stargate $500B, AI data center electricity water grid strain, AI scheming OpenAI ChatGPT, Estonia gut microbiome drugs study, antidepressants beta-blockers proton pump inhibitors benzos, long-term gut health risks cancer Alzheimer's

So many of us feel like we're always behind, convinced that the right planner or app will finally fix our schedules. But as Anna Dearmon Kornick - time management coach, author of Time Management Essentials: The Tools You Need to Maximize Your Attention, Energy, and Productivity , and host of the It's About Time podcast - explains, true time management doesn't start with hacks. It starts with clarity on what matters most. In this conversation, Anna and I dive into productivity pitfalls, the myth of multitasking, and practical tools like time blocking, creating an ideal week, and simple weekly planning sessions. If you've ever felt overwhelmed, distracted, or like your priorities are slipping through the cracks, this episode is packed with encouragement and strategies to help you manage your time with purpose. What You'll Learn in This Episode: Why purpose — rooted in your vision and values — is the foundation of time management How time blocking helps combat Parkinson's Law, the planning fallacy, and context switching Why creating an “ideal week” matters more than aiming for a “perfect day” Five essential routines that support a well-managed life A step-by-step approach to weekly planning — even when you're overwhelmed More about Anna: A true Louisiana firecracker who has become known for making time management fun, Anna helps busy professionals and business owners struggling with overwhelm manage their time using her personality-driven HEART Method. Resources Mentioned: Connect with Anna Dearmon Kornick: Website: annadkornick.com Podcast: It's About Time Book: Time Management Essentials: The Tools You Need to Maximize Your Attention, Energy, and Productivity Instagram: @annadkornick Join the It's About Time Challenge Related Episodes: Episode 37: Take Control of Your Time and Be a More Intentional Mom with Julie Redmond from Mom Made Plans Episode 166: Why Compassionate Time Management Matters - with Kendra Adachi from The Lazy Genius Episode 195: Secrets of Supermoms: Master Work-Life Balance, Boost Your Energy, Find True Rest, and Expect the Unexpected - with Lori Oberbroeckling *** I help moms declutter their homes, heads, and hearts. Contact - > info@simplebyemmy.com  Podcast -＞ https://www.simplebyemmy.com/podcast Learn -＞ https://www.simplebyemmy.com/resources Connect -＞ Join our free Facebook group Decluttering Tips and Support for Overwhelmed Moms Instagram -＞ @simplebyemmy and @momsovercomingoverwhelm   *** Don't Know Where to Start? *** 5 Steps to Overcome Overwhelm -＞ https://simplebyemmy.com/5steps/ 5 Mindset Shifts for Decluttering -＞ https://simplebyemmy.com/mindset/   Wanna work with me to kick overwhelm to the curb, mama? There are three options for you! Step 1: Join a supportive community of moms plus decluttering challenges to keep you on track at the free Facebook group Decluttering Tips and Support for Overwhelmed Moms Step 2: Sign up for the weekly Decluttering Tips and Resources for Overwhelmed Moms Newsletter and see samples here: https://pages.simplebyemmy.com/profile Step 3: Get more personalized support with in-person decluttering and organization coaching (Washington DC metro area)! https://www.simplebyemmy.com/workwithme

What if the secret to unlocking the mysteries of our minds, our health, and even our happiness is hiding in the most unexpected place—our own gut? Could the answers to our most stubborn health mysteries—and maybe even the secret to a longer, happier life—be found in the microbes we've spent a lifetime trying to avoid?How does our microbiome affect conditions like depression, Parkinson's, and autism?Research from this week's guest shows that optimizing microbial health can dramatically improve our quality of life, leading to enhanced memory and cognition and reversing symptoms of Alzheimer's. After microbial transplants, some patients even started regrowing their hair! Our guest today, Dr. Sabine Hazan, is a trailblazer and pioneering specialist in gastroenterology, internal medicine, and hepatology. Dr. Hazan is the Founder & CEO of the Malibu Specialty Center and Ventura Clinical Trials where she conducts and oversees clinical trials for cutting-edge research. She's also a top clinical investigator for multiple pharmaceutical companies, and an author to boot.In this episode, you'll discover:The many unexpected benefits of microbiome transplantsHow sunlight, exercise, and hobbies like gardening actually improve our microbial health and resilienceHow changing the way we think affects our microbiomeAnd much more…Find Dr. Sabine Hazan and her work on: progenabiome.comPick up the book, Let's Talk Sh!t, on Barnes and Noble or progenabiome.comListen to the Let's Talk Sh!t podcast with Dr. Sabine Hazan on progenabiome.com, letstalkshit.org, Apple Podcasts, Audible, YouTube or wherever you listen to podcastsGo to microbiomeresearchfoundation.org for cutting-edge information from Dr. Hazen and the Biome SquadMake sure you're subscribed to the Abel James Show, and to stay up-to-date, sign up for my newsletter at AbelJames.com.You can also join Substack as a free or paid member for ad-free episodes of this show, to comment on each episode, and to hit me up in the DM's. Join at abeljames.substack.com. And if you're feeling generous, write a quick review for the Abel James Show on Apple or Spotify. You rock.This episode is brought to you by:Manukora - Go to MANUKORA.com/WILD to save 31% plus $25 of free gifts.Troscriptions - Go to Troscriptions.com/WILD or enter WILD at checkout for 10% off your first order.Crowd Health - Go to JoinCrowdHealth.com and use the code WILD at checkout to get started for as low as $80 per month.

My man Keith Johnson of @Kjsawdust is back. Amazing furniture maker and Walnut savant is back! And guess what? We didn't discuss work at all. We just talked and told stories and had no mention of wood steel or anything like that. - Keith is the Man and a lot of fun to hang out with. Many thanks my buddy. - GFFollow Keith on Instagram: https://www.instagram.com/kjsawdust?igsh=ZXgzcnI4MjF0dnhzFollow Keith on Youtube: keith johnson woodworking - YouTubeListen to the Shop Sounds Podcast: https://podcasts.apple.com/us/podcast/shop-sounds-podcast/id1514814400The Full Blast Podcast on Instagram:https://instagram.com/thefullblastpodcast?igshid=YmMyMTA2M2Y=If you want to support my race for the NYC Marathon as I raise money for Parkinson's Research please do here:https://give.michaeljfox.org/fundraiser/6151559 If you want to support Full Blast Support  Feder Knives - ( go buy a shirt )https://www.federknives.com/Go to CMA's website and check out the opportunities: https://centerformetalarts.org/Take a class: https://centerformetalarts.org/Follow CMA on Instagram https://www.instagram.com/centerformetalarts/?hl=enPlease subscribe, leave a review and tell your friends about the show. it helps me out a lot! Welcome aboard Phoenix Abrasives!Phoenixabrasives.com Phoenix abrasives supplies superior abrasive products for every application. Knifemaking, Metal fabrication, glass fab, floor sanding and Crankshaft! Belts, grinding and cutting discs, Flap Discs, surface conditioning FB10 at checkout gets 10% off your order at Check out.Welcome back! Nordic Edge:@nordic_edge on IG Nordicedge.com.auNordic Edge is about the joy of making something with your own hands. our one stop shop for tools, supplies and help when it comes to knife making, blacksmithing, leatherworking, spoon carving and other crafts where you get to take some time out for yourself and turn an idea into something tangible. Nordic Edge also holds hands-on workshops in the “lost arts” of blacksmithing, knife making and spoon carving. Come spend a day with us and go home with new skills and something you made with your own hands. They have the  guidance to help accelerate your creativity and the  Tools, products, supplies to help you manifest your ideas. NordicEdge.com.auThank you Baker Forge & Tool for your beautiful Steel. Go to Bakerforge.com to see all the incredible steels they offer. ‘FullBlast' gets you 10% off your order. CHECK OUT THE NEW ADDITIONS TO THE GATOR PISS LINE - GATOR PISS MAX & GATOR PISS HEAVYWelcome to our new Sponsor- EVENHEAT- Manufacturers of the best heat treating ovens available.  To find your next oven go to Evenheat-kiln.comFollow them on Instagram: Welcome aboard Texas Farrier Supply! For all your forging and knife making supplies go to www.texasfarriersupply.com   and get 10% off your order with PROMOCODE Knifetalk10Brodbeck Ironworks Makers of an Incredibly versatile grinder, with Many different attachmentsLeather sewing equipment and even abrasives Check out Brodbeck Ironworks for yourself:https://brodbeckironworks.com/“Knifetalk10” gets you 10% off Follow Brodbeck Ironworks on Instagramhttps://www.instagram.com/brodbeck_ironworks/Trojan Horse Forge Get your THF Stabile Rail knife finishing vise at https://www.trojanhorseforge.com/And when you use the promo code “FULLBLAST10 you get 10%off everything on the site.Follow them on instagram:https://www.instagram.com/trojan_horse_forge/ TotalBoatAdhesives, paints, primers and polishing compounds.Go to http://totalboat.com/FULLBLASTTo support the podcastG.L. Hansen & Sons On Instagramhttps://instagram.com/g.l._hansenandsons?igshid=MzRlODBiNWFlZA== Gcarta.bigcartel.comG-Carta is unique composite of natural fibers and fabrics mixed with epoxy under pressure and heat Boofa, ripple cut, Tuxini, by Mikie, Mahi Mahi, Radio worm g-cartaPheasant by MikieColorama by MikieHoopla by MikeAmazing colors and razzle dazzle for your project. MARITIME KNIFE SUPPLIESMaritimeknifesupply.CAAll your knifemaking needs, belts abrasive, steals, kilns forges presses, heat treating ovens anvils and everything you need to get started or resupply. Including Dr. Thomas's book:“Knife Engineering”They're in Canada but ship to the US with ease and you can take advantage of the exchange rate The steel selection is always growing and Lawrence just got 3900 lbs. of steel in.10% off on abrasive belt packs of 10 get a hold of https://www.instagram.com/maritimeknifesupply/ and see what the fuss is about.Welcome Tormek as a sponsor to the show. Take your sharpening to a new level. I love these sharpening machines. Waterfed, easy to use. Jigs included. Definitely check out what they have to offer. If you need it sharpened, Tormek is definitely something for you:https://tormek.com/en/inspiration/woodworking--craftsVisit Tormek's website: https://tormek.com/enFollow Tormek on Instagram:https://www.instagram.com/tormek_sharpening/?hl=enFollow Tormek on TikTokhttps://www.tiktok.com/@tormek_sharpening?lang=enGo look at the course curriculum at CMA:https://centerformetalarts.org/workshops/** Taking classes from some of the best in forging at one of the best facilities in the country is an excellent opportunity to propel yourself as a blacksmith. Not to be missed. And with housing on the campus it's a great way to get yourself to the next level. Advertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

This episode was recorded on the morning of September 10th. This episode opens with an emotional reflection and 4 things Christian Dads can do right now. And then we get into the show. When John O'Leary was just 9 years old, he suffered burns over 100% of his body in a house fire. Doctors gave him less than 1% chance to survive. And yet, by God's grace, the love of his parents and the courage of the community, John not only survived - he has gone on to live a life on fire with purpose! He's a best-selling author, a sought-after speaker, and now the subject of an upcoming major motion picture Soul On Fire, releasing nationwide October 10th. John's story isn't just about tragedy, it's about faith, family and choosing to live life fully alive. On this episode, we talk about John's tragedy at 9, self-worth, physical and mental struggle, Jesus examples of how to live and John's memories about his dad Denny O'Leary. We also share some stories about a few actors in the movie; William H Macy and Joel Courtney. What are John's memories of who his dad was and what was it like being selected to give his eulogy? When your kids write your eulogy, what will they write? Why did John's dad call his Parkinson's disease a gift from God? What lessons did John learn while in the hospital for months? What's it like when your dad get a life changing medical diagnosis? This is a movie that the world needs now. It's the story of the greatest human I've met and the stories of all the heros that helped him live and live life on fire!  My immediate thoughts after watching the movie was that I am so grateful I got to see it at the theater with people I love. This is great movie to experience with others. We are hoping that this movie inspires 1,000,000 people opening weekend. My ASK is that you bring your family to the movie opening weekend and encourage others to see it as well. It is very important to have a big opening weekend. It helps the movie stay in theaters longer and therefore more people will see it. Share this episode with others, let people know that you are going to see the movie, use hashtag #soulonfiremovie, and help grow awareness of this movie. Challenge: Let's fill up theaters and vote for good. Go to a film about family, grace, heros and unconditional love! Talk after the movie about who the heros were and how to live differently. The movie comes out October 10th! Let's do our part to impact the world with this movie.  Please let me know if you are going to the movie. PM me or email me at TheChristianDadPodcast@gmail.com . And if you'd like Ignite Character series that John mentions, I'll send you a free link.   Here is a link to the movie trailer CLICK HERE Check out the official Soul On Fire movie website and buy tickets HERE If you liked this episode, listen to John's first appearance on the podcast in 2022 HERE Join our FREE Facebook Community The Journey of a Christian Dad HERE        

Welcome to another episode of the Superhumanize Podcast,
where we explore the intersection of science, self-healing, and sovereignty. I am your host, Ariane Sommer.
And today, we are entering one of the most promising frontiers in regenerative health: stem cell support, not through invasive procedures, but through the intelligence of the body itself. My guest is Ryan Riley, CEO of Stemregen, a company at the forefront of developing plant-based stem cell enhancers that work with your biology, mobilizing your body's own master repair cells using natural compounds backed by over two decades of research. This is not science fiction. This is clinical science, blending natural ingredients like sea buckthorn, Aloe macroclada, and blue-green algae into a protocol designed to support stem cell release, circulation, and communication.In our conversation, Ryan and I explore, why stem cells are the body's innate repair system, how inflammation and microcirculation can block or accelerate healing, and how simple, evidence-backed daily practices can reawaken the body's regenerative potential. We will also discuss compelling clinical and anecdotal results from early studies,
including breakthroughs in heart function, neurological health, and trauma recovery.Whether you are navigating chronic illness, exploring new pathways to vitality,
or simply seeking to become a more sovereign steward of your health,
this episode offers insight, direction, and empowerment.Episode HighlightsRyan Riley shares his journey from tech entrepreneur to wellness innovator, bridging science and holistic health.The role of stem cells in the body's natural repair system and how their circulation declines with age.How natural botanicals like blue-green algae, aloe, and goji berry can support stem cell mobilization.Early studies showing promise in conditions like heart disease and Parkinson's when stem cell activation is supported.Ryan's personal experiences with endurance sports and how stem cell support aided recovery and performance.The integration of mindset, belief, and emotional health in physical healing.Why bridging naturopathic and allopathic medicine could be the future of healthcare.The importance of shifting from reactive to proactive care in supporting longevity.ResourcesStemRegen – https://stemregen.coChristian Drapeau (stem cell scientist) on TikTok & Instagram – search “Christian Drapeau”Ryan Riley's work with StemRegen – https://stemregen.coSOCIAL MEDIAYouTube https://www.youtube.com/@stemregenInstagram https://www.instagram.com/stemregen/Facebook https://www.facebook.com/STEMREGENOfficial/X https://x.com/stemregen

Low Muscle Power Increases Risk of Death Podcast || Dare to Be Vital BookFIVE PRIMARY POINTS THE PODCAST:Deep Breathing vs. Microdosing PsychedelicsMusic-facilitated deep breathing protocols can evoke altered states of consciousness similar to those reported with psychedelic microdosing. Participants experienced less fear and sadness, unity, and bliss—without the risks of psychedelics. This suggests breathwork may be a safe, non-pharmacologic tool for mood regulation and mental health.Fasting Preserves StrengthA study of a 12-day very low-calorie fast (≤250 calories/day) showed muscle mass shrank mostly due to water loss, not tissue breakdown. Strength and power were preserved, fat was used efficiently for energy, mitochondria stayed healthy, and women even improved fat metabolism. Fasting may also help prevent neurological diseases like Alzheimer's and Parkinson's.Purpose Protects the BrainA large 15-year study of nearly 14,000 people found those with a higher sense of purpose had a 28% lower risk of dementia, even after accounting for genetics, education, and depression. Purpose is highlighted as the most important modifiable vitality asset—choosing and clarifying one's purpose can directly improve long-term health and resilience.Breathing as a Vitality SuperpowerConscious breathing affects longevity, mood, focus, and sleep. Proper nose breathing boosts oxygenation and brain function, while techniques like cyclic sighing, 4-7-8 breathing, and box breathing improve mood, reduce stress, and enhance focus. Oxygen saturation above 96% is a key biomarker of longevity.Actionable Takeaways* Explore deep breathing as a drug-free therapy for mental well-being.* Use fasting strategically for weight control and brain protection.* Define a personal purpose statement (≤8 words) to guide decisions and boost vitality.* Adopt simple daily breathing practices for health and performance.* Purpose and deep breathing are core pillars of long-term vitality.Copyright VyVerse®, LLC. All Rights Reserved. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit vitalityexplorers.substack.com/subscribe

In this episode, host Sandy Vance sits down with Henry O'Connell, Co-Founder & CEO of Canary Speech, to explore how voice AI is transforming healthcare. Canary Speech is pioneering vocal biomarker technology—using subtle patterns in speech to replace subjective assessments with objective, actionable data.From measuring pain levels to aiding in the diagnosis of conditions like Anxiety, depression, Huntington's, Parkinson's, MCI, Canary's tools are designed to improve accuracy and speed in healthcare decision-making. This innovation not only helps patients receive the right care faster, but also supports nurses and clinicians by reducing burnout, improving workplace safety, and streamlining workflows.If you're curious about the future of AI in healthcare, digital health innovation, or how speech analysis can change the way we approach diagnostics and patient care, this conversation is packed with insights you won't want to miss.In this episode, they talk about:Addressing the growing challenge of aggression in healthcare settingsMeasuring ROI while reducing risk, preventing burnout, and improving employee retentionUsing voice AI to assist in diagnosing ADHD, autism, and scaling pain assessmentsUpcoming projects at Canary Speech, including collaboration with Microsoft's Dragon softwareHelping providers deliver more empathetic, patient-centered careFast implementation! Canary can be deployed in days, not weeks, for new clientsA Little About Henry:Henry O'Connell is the CEO and co-founder of Canary Speech, a leading AI health tech company using real-time vocal biomarkers to screen for mental health and neurological conditions. With over two decades of experience in technology leadership, including roles at Hewlett-Packard, Gilson, and the NIH, he has served on the boards of multiple tech companies globally. A passionate advocate for voice technology in healthcare, O'Connell regularly speaks on the transformative potential of AI and vocal biomarkers to improve disease detection, patient monitoring, and clinical decision-making. He aims to provide health screening that is accessible, objective, and scalable.

Key Points Robin Swan explains her indigenous background and lifelong experience with psychotropic substances through the Native American church, having used peyote since childhood and incorporating psilocybin into her apothecary practice since 2014.Psilocybin mushrooms grow on every continent making them an open practice for humanity, with mycelium mapping similarly to the human central nervous system and representing the first life form to emerge from water according to creation theory.Depression and brain cancers became the primary focus for incorporating psilocybin into Swan's practice because cannabis wasn't adequately addressing these conditions, particularly given that mushrooms create neuroplasticity and open new neural pathways.Working with NFL players and pro sports athletes for 15 years revealed that psilocybin significantly helped traumatic brain injury and concussion recovery where cannabis had limited effectiveness.One unnamed NFL commentator client with 12 concussions showed dramatic improvement within three weeks of psilocybin microdosing, regaining speech clarity, eliminating blank stares, and completely stopping massive migraines that pharmaceuticals couldn't treat.Different psilocybin mushroom varieties serve distinct therapeutic purposes, with cubensis being electric and external for traditional psychedelic experiences, while azurescens provide internal experiences that create neuroplasticity specifically beneficial for brain cancer patients.Clinical studies from Johns Hopkins University, Harvard, and Emory University have documented psilocybin's therapeutic potential across 170 studies covering treatment-resistant depression, anxiety, PTSD, Alzheimer's, Parkinson's, chronic pain, and immune system modulation.Parkinson's disease treatment with psilocybin shows remarkable results in reducing shakiness and mood swings while helping patients navigate daily challenges, while Alzheimer's patients become more fluid and maintain better memory connections.Psilocin, the active ingredient in psilocybin, remains active for only three days once extracted and requires specific ingestion methods, with lemon juice extraction providing faster onset within 15 minutes compared to capsules taking up to four hours.Swan Apothecary offers various psilocybin products including capsules, chocolate bars, lemon-extracted psilocin products, and a "hero dose" journey product containing 3.5 grams, all requiring two years of research and development before market release.Cannabis and psilocybin produce completely different experiences, with cannabis providing cannabinoid profiles while mushrooms maintain individual properties and create visions, heart-opening effects, and consciousness expansion that may have driven human evolution from apes.Common misconceptions about psilocybin include fears of wall-melting hallucinations and bad experiences, though the substance is safer than LSD as a natural fungus lasting 4-6 hours with potential weeks-long afterglow effects.Proper dosing and timing matter significantly for psilocybin effectiveness, with insufficient doses or full stomachs preventing activation, while the substance helps end-of-life patients live longer and have meaningful conversations with loved ones.Swan emphasizes that mushrooms help people embrace living in the present moment rather than fighting for future life, citing client Sally who lived nine years beyond her initial diagnosis and taught the importance of conscious, empowered living during terminal illness. Visit our website: CannabisHealthRadio.comFind high-quality cannabis and CBD + get free consultations at MyFitLife.net/cannabishealthDiscover products and get expert advice from Swan ApothecaryFollow us on Facebook.Follow us on Instagram.Find us on Rumble.Keep your privacy! Buy NixT420 Odor Remover Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In October 2018, the Hampshire town of Gosport was left reeling after the sudden and violent death of respected academic Dr Barry Hounsome.Barry was a devoted husband, a supportive son, and a stepfather who took on the role of “Dad” with love and pride. Away from his home life, his career was dedicated to improving the lives of others through groundbreaking research into dementia and Parkinson's disease.When Barry's life was cut short inside his own home, the case that followed revealed unsettling questions about family, responsibility, and the fine line between illness and intent.Join my Patreon community at patreon.com/britishmurders for exclusive perks, including early access to ad-free episodes, exclusive episodes and content, exciting giveaways, and welcome goodies! It's quick to sign up and you'll save 20% if you choose an annual membership. NOTE: Perks are only available to members of my 'Armchair Detectives' and 'Inner Circle' tiers.Follow me on social media:Facebook | British Murders with Stuart BluesInstagram | @britishmurdersJoin the private Facebook group:British Murders Podcast - Discussion GroupVisit my website:britishmurders.comIntro music:⁣David John Brady - 'Throw Down the Gauntlet'⁣davidjohnbrady.comDisclaimer:The case discussed in this podcast episode is real and represents the worst day in many people's lives. I aim to cover such stories with a victim-focused approach, using information from publicly available sources. While I strive for accuracy, some details may vary depending on the sources used. You can find the sources for each episode on my website. Due to the nature of the content, listener discretion is advised. Thank you for your understanding and support. Hosted on Acast. See acast.com/privacy for more information.

Could a natural compound from everyday spices protect your brain and slow the progression of Parkinson's Disease? In this episode (watch on YouTube here!) you will learn about β-caryophyllene (BCP)—a safe, plant-derived compound found in black pepper, rosemary, and hops. BCP is FDA- and EFSA-approved as a flavor enhancer, but research suggests it does far more. What you'll learn in this episode: ✅ How BCP protects dopamine neurons in the substantia nigra ✅ Its potential role in stabilizing Parkinson's and slowing progression  ✅ Symptom relief for pain, restless legs, muscle hesitation, depression, anxiety, and sleep issues ✅ How BCP may treat tardive dyskinesia caused by medications ✅ BCP's broader neuroprotective, anti-inflammatory, and antioxidant properties Whether you're living with Parkinson's, caring for someone who is, or interested in natural neuroprotection, this episode will expand your understanding of what's possible. Be sure to explore the BCP products that you heard about in this episode that are available from Blair Medical Group via this link (Enter promo code PDEDUCATION for a 10% discount on your order): https://www.blairmedicalgroup.shop/shop/bcplus-endocannabinoid-activation-products/2?aff=22

Today's Guest Laura Orrico is a versatile SAG-AFTRA actress known for her impeccable comedic timing and dramatic range, which have made her a sought-after talent in the industry. With work spanning both film and television, she has built an impressive career with notable roles on hit shows such as CBS's Kevin Can Wait, The King of Queens, CSI: Miami, FOX's That '70s Show, and That Show Tonight. Laura was also a series regular on Frank TV on TBS, where her sharp wit was seen nationwide. Her work extends beyond television, with recent film credits including The Buddy Cop (2024), God's Fool (2020), and Brennan (2016), seen in theaters and on Netflix and Amazon. Her comedic talents gained fame on the internet, as her self-produced videos went viral, earning her featured status across multiple platforms. Her most successful internet sketch was developed by legendary director David Zucker (Airplane!, Naked Gun, etc.), in which she was aged 40 years for the role. In addition to her acting career, Laura is the founder of Laura Orrico Public Relations, LLC, a highly respected PR firm that represents high-profile clients across the country. Her public relations expertise gives her a unique understanding of the industry, both in front of and behind the camera, and draws attention to any project she is a part of. Behind the scenes, Laura's personal story of resilience and perseverance shapes her deeply authentic performances. After the loss of her father at a young age, becoming a widow at 38, and now caring for her mother with MS and Parkinson's, Laura brings raw, emotional depth to her characters. A true professional, Laura is known for being a “one-take wonder” and impressing directors with her preparation and dedication. She continues to power through successfully while handling so much and cementing her place as a dynamic talent in Hollywood and beyond. Her journey has also made her a compelling voice in the media, leading to interviews like her recent appearance on PBS's nationally syndicated The Whitney Reynolds Show, where she shared her story of strength, reinvention, and finding purpose through adversity. Just recently, Laura decided to go public across her social media platforms with her journey of pursuing IVF solo using her late husband's sperm. Her story has gained a lot of traction and support from women and even men! Laura has been featured in major publications including Vanity Fair, Deadline Hollywood, USA Today, Daily Mail, Forbes, Hollywood.com, has made recurring appearances on NTD News, and guested on TV shows such as Red Eye with Greg Gutfeld and Strictly Speaking with Bob Frantz. Her contributions to the industry continue to be recognized on television, radio shows, and podcasts across the country. Links for Laura Website: www.lauraorrico.comIMDb: www.imdb.com/name/nm1276900Linkedin: https://www.linkedin.com/in/laura-orrico-publicrelations/Facebook: http://www.facebook.com/lauraorricoofficialpage/X: http://www.twitter.com/laura_orricoInstagram: http://www.instagram.com/thelauraorrico/YouTube: https://www.youtube.com/@lauraorricoTikTok: https://www.tiktok.com/@thelauraorrico About Dr. Raj Dr Raj is a quadruple board certified physician and associate professor at the University of Southern California. He was a co-host on the TNT series Chasing the Cure with Ann Curry, a regular on the TV Show The Doctors for the past 7 seasons and has a weekly medical segment on ABC news Los Angeles. More from Dr. Raj ⁠⁠⁠The Dr. Raj Podcast⁠⁠⁠ ⁠⁠⁠Dr. Raj on Twitter⁠⁠⁠ ⁠⁠⁠Dr. Raj on Instagram⁠⁠⁠ Want more board review content? ⁠⁠⁠USMLE Step 1 Ad-Free Bundle⁠⁠⁠ ⁠⁠⁠Crush Step 1⁠⁠⁠ ⁠⁠⁠Step 2 Secrets⁠⁠⁠ ⁠⁠⁠Beyond the Pearls⁠⁠⁠ ⁠⁠⁠The Dr. Raj Podcast⁠⁠⁠ ⁠⁠⁠Beyond the Pearls Premium⁠⁠⁠ ⁠⁠⁠USMLE Step 3 Review⁠⁠⁠ ⁠⁠⁠MedPrepTGo Step 1 Questions⁠⁠⁠ ⁠⁠⁠MedPrepTGo Step 2 Questions⁠ Learn more about your ad choices. Visit megaphone.fm/adchoices

September is Fall Prevention month. As we age, falling—or even the fear of falling—becomes increasingly common. For people with Parkinson's, the risk is often higher due to specific changes in the body that affect balance, strength, and coordination. Almost all of us will experience a fall at some point, which is why it's so important to understand your abilities, recognize your tendencies, and keep open communication with your neurologist and care team. The good news is that there are effective ways to improve balance, manage dizziness, and build strength. Prevention truly is key. Today, I have two special guests joining me: ·       Dr. Ospina, a Movement Disorder Specialist (MDS), who explains why people with Parkinson's are more likely to face fall risks as part of the disease process—and what's happening in the body that leads to falls. She also shares strategies and treatments that can help reduce those risks. ·       A home safety expert, whose company evaluates living spaces and provides personalized recommendations to make your home safer. Their process is clinically guided, ensuring that the solutions fit your individual needs. This service is incredibly valuable for anyone looking to prevent falls at home. As we recognize Fall Prevention Month, I'd love to hear from you. Do you have a personal story about a fall, or tips you've used to reduce your ownl risk? Please share your experiences in the comments section or email at info@17branches.org.  Thank you to our sponsor – Boston Scientific, the maker of Vercise Genus, a Deep Brain Stimulation or DBS system. To learn more about the latest treatment options for Parkinson's disease at https://DBSandMe.com/17branches  https://www.dbsandme.com/17branches  https://measurabilities.com/ https://www.cdc.gov/falls/about/index.html    

Paroxysmal movement disorders refer to a group of highly heterogeneous disorders that present with attacks of involuntary movements without loss of consciousness. These disorders demonstrate considerable and ever-expanding genetic and clinical heterogeneity, so an accurate clinical diagnosis has key therapeutic implications. In this episode, Kait Nevel, MD, speaks with Abhimanyu Mahajan, MD, MHS, FAAN, author of the article “Paroxysmal Movement Disorders” in the Continuum® August 2025 Movement Disorders issue. Dr. Nevel is a Continuum® Audio interviewer and a neurologist and neuro-oncologist at Indiana University School of Medicine in Indianapolis, Indiana. Dr. Mahajan is an assistant professor of neurology and rehabilitation medicine at the James J. and Joan A. Gardner Family Center for Parkinson's Disease and Movement Disorders at the University of Cincinnati in Cincinnati, Ohio. Additional Resources Read the article: Paroxysmal Movement Disorders Subscribe to Continuum®: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Host: @IUneurodocmom Guest: @MahajanMD Full episode transcript available here Dr Jones: This is Doctor Lyell Jones, editor in chief of Continuum. Thank you for listening to Continuum Audio. Be sure to visit the links in the episode notes for information about earning CME, subscribing to the journal, and exclusive access to interviews not featured on the podcast. Dr Nevel: Hello, this is Dr Kait Nevel. Today I'm interviewing doctor Abhi Mahajan about his article on diagnosis and management of paroxysmal movement disorders, which appears in the August 2025 Continuum issue on movement disorders. Abhi, welcome to the podcast and please introduce yourself to the audience. Dr Mahajan: Thank you, Kait. Thank you for inviting me. My name is Abhi Mahajan. I'm an assistant professor of neurology and rehabilitation medicine at the University of Cincinnati in Cincinnati, Ohio. I'm happy to be here. Dr Nevel: Wonderful. Well, I'm really excited to talk to you about your article today on this very interesting and unique set of movement disorders. So, before we get into your article a little bit more, I think just kind of the set the stage for the discussion so that we're all on the same page. Could you start us off with some definitions? What are paroxysmal movement disorders? And generally, how do we start to kind of categorize these in our minds? Dr Mahajan: So, the term paroxysmal movement disorders refers to a group of highly heterogeneous disorders. These may present with attacks of involuntary movements, commonly a combination of dystonia and chorea, or ataxia, or both. These movements are typically without loss of consciousness and may follow, may follow, so with or without known triggers. In terms of the classification, these have been classified in a number of ways. Classically, these have been classified based on the trigger. So, if the paroxysmal movement disorder follows activity, these are called kinesigenic, paroxysmal, kinesigenic dyskinesia. If they are not followed by activity, they're called non kinesigenic dyskinesia and then if they've followed prolonged activity or exercise they're called paroxysmal exercise induced dyskinesia. There's a separate but related group of protogynous movement disorders called episodic attacks here that can have their own triggers. Initially this was the classification that was said. Subsequent classifications have placed their focus on the ideology of these attacks that could be familiar or acquired and of course understanding of familiar or genetic causes of paroxysmal movement disorders keeps on expanding and so on and so forth. And more recently, response to pharmacotherapy and specific clinical features have also been introduced into the classification. Dr Nevel: Great, thank you for that. Can you share with us what you think is the most important takeaway from your article for the practicing neurologist? Dr Mahajan: Absolutely. I think it's important to recognize that everything that looks and sounds bizarre should not be dismissed as malingering. Such hyperkinetic and again in quotations, “bizarre movements”. They may appear functional to the untrained eye or the lazy eye. These movements can be diagnosed. Paroxysmal movement disorders can be diagnosed with a good clinical history and exam and may be treated with a lot of success with medications that are readily available and cheap. So, you can actually make a huge amount of difference to your patients' lives by practicing old-school neurology. Dr Nevel: That's great, thank you so much for that. I can imagine that scenario does come up where somebody is thought to have a functional neurological disorder but really has a proximal movement disorder. You mentioned that in your article, how it's important to distinguish between these two, how there can be similarities at times. Do you mind giving us a little bit more in terms of how do we differentiate between functional neurologic disorder and paroxysmal movement disorder? Dr Mahajan: So clinical differentiation of functional neurological disorder from paroxysmal movement disorders, of course it's really important as a management is completely different, but it can be quite challenging. There's certainly an overlap. So, there can be an overlap with presentation, with phenomenology. Paroxysmal nature is common to both of them. In addition, FND and PMD's may commonly share triggers, whether they are movement, physical exercise. Other triggers include emotional stimuli, even touch or auditory stimuli. What makes it even more challenging is that FND's may coexist with other neurological disorders, including paroxysmal movement disorders. However, there are certain specific phenom phenotypic differences that have been reported. So specific presentations, for example the paroxysms may look different. Each paroxysm may look different in functional neurological disorders, specific phenotypes like paroxysmal akinesia. So, these are long duration episodes with eyes closed. Certain kinds of paroxysmal hyperkinesia with ataxia and dystonia have been reported. Of course. More commonly we see PNES of paroxysmal nonepileptic spells or seizures that may be considered paroxysmal movement disorders but represent completely different etiology which is FND. Within the world of movement disorders, functional jerks may resemble propiospinal myoclonus which is a completely different entity. Overall, there are certain things that help separate functional movement disorders from paroxysmal movement disorders, such as an acute onset variable and inconsistent phenomenology. They can be suggestibility, distractibility, entrainment, the use of an EMG may show a B-potential (Bereitschaftspotential) preceding the movement in patients with FND. So, all of these cues are really helpful. Dr Nevel: Great, thanks. When you're seeing a patient who's reporting to these paroxysmal uncontrollable movements, what kind of features of their story really tips you off that this might be a proximal movement disorder? Dr Mahajan: Often these patients have been diagnosed with functional neurological disorders and they come to us. But for me, whenever the patient and or the family talk about episodic movements, I think about these. Honestly, we must be aware that there is a possibility that the movements that the patients are reporting that you may not see in clinic. Maybe there are obvious movement disorders. Specifically, there's certain clues that you should always ask for in the history, for example, ask for the age of onset, a description of movements. Patients typically have videos or families have videos. You may not be able to see them in clinic. The regularity of frequency of these movements, how long the attacks are, is there any family history of or not? On the basis of triggers, whether, as I mentioned before, do these follow exercise? Prolonged exercise? Or neither of the above? What is the presentation in between attacks, which I think is a very important clinical clue. Your examination may be limited to videos, but it's important not just to examine the video which represents the patient during an attack, but in between attacks. That is important. And of course, I suspect we'll get to the treatment, but the treatment can follow just this part, the history and physical exam. It may be refined with further testing, including genetic testing. Dr Nevel: Great. On the note of genetic testing, when you do suspect a diagnosis of paroxysmal movement disorder, what are some key points for the provider to be aware of about genetic testing? How do we go about that? I know that there are lots of different options for genetic testing and it gets complicated. What do you suggest? Dr Mahajan: Traditionally, things were a little bit easier, right, because we had a couple of genes that have been associated with the robust movement disorders. So, genetic testing included single gene testing, testing for PRRT2 followed by SLC2A. And if these were negative, you said, well, this is not a genetic ideology for paroxysmal movement disorders. Of course, with time that has changed. There's an increase in known genes and variants. There is increased genetic entropy. So, the same genetic mutation may present with many phenotypes and different genetic mutations may present with the similar phenotype. Single gene testing is not a high yield approach. Overall genetic investigations for paroxysmal movement disorders use next generation sequencing or whole exome sequence panels which allow for sequencing of multiple genes simultaneously. The reported diagnostic yield with let's say next generation sequencing is around 35 to 50 percent. Specific labs at centers have developed their own panels which may improve the yield of course. In children, microarray may be considered, especially the presentation includes epilepsy or intellectual disability because copy number variations may not be detected by a whole exome sequencing or next generation sequencing. Overall, I will tell you that I'm certainly not an expert in genetics, so whenever you're considering genetic testing, if possible, please utilize the expertise of a genetic counsellor. Families want to know, especially as an understanding of the molecular underpinnings and knowledge about associated mutations or variations keeps on expanding. We need to incorporate their expertise. A variant of unknown significance, which is quite a common result with genetic testing, may not be a variant of unknown significance next year may be reclassified as pathogenic. So, this is extremely important. Dr Nevel: Yeah. That's such a good point. Thank you. And you just mentioned that there are some genetic mutations that can lead to multiple different phenotypes. Seemingly similar phenotypes can be associated with various genetic mutations. What's our understanding of that? Do we have an understanding of that? Why there is this seeming disconnect at times between the specific genetic mutation and the phenotype? Dr Mahajan: That is a tough question to answer for all paroxysmal movement disorders because the answer may be specific to a specific mutation. I think a great example is the CACNA1A mutation. It is a common cause of episodic ataxia type 2. Depending on when the patient presents, you can have a whole gamut of clinical presentations. So, if the patient is 1 year old, the patient can present with epileptic encephalopathy. Two to 5 years, it can be benign paroxysmal torticollis of infancy. Five to 10 years, can present with learning difficulties with absence epilepsy and then of course later, greater than 10 years, with episodic ataxia (type) 2 hemiplegic migraine and then a presentation with progressive ataxia and hemiplegic migraines has also been reported. So not just episodic progressive form of ataxia has also been reported. I think overall these disorders are very rare. They are even more infrequently diagnosed than their prevalence. As such, the point that different genetic mutations present with different phenotypes, or the same genetic mutation I may present with different phenotypes could also represent this part. Understanding of the clinical presentation is really incomplete and forever growing. There's a new case report or case series every other month, which makes this a little bit challenging, but that's all the more reason for learning about them and for constant vigilance for patients who show up to our clinic. Dr Nevel: Yeah, absolutely. What is our current understanding of the associated pathophysiology of these conditions and the pathophysiology relating to the genetics? And then how does that relate to the treatment of these conditions? Dr Mahajan: So, a number of different disease mechanisms have been proposed. Traditionally, these were all thought to be ion channelopathies, but a number of different processes have been proposed now. So, depending on the genetic mutation that you talk about. So certain mutations can involve ion channels such as CACMA1A, ATP1A3. It can involve solute carriers, synaptic vesicle fusion, energy metabolism such as ECHS1, synthesis of neurotransmitters such as GCH1. So, there are multiple processes that may be involved. I think overall for the practicing clinician such as me, I think there is a greater need for us to understand the underlying genetics and associated phenotypes and the molecular mechanisms specifically because these can actually influence treatment decisions, right? So, you mentioned that specific genetic testing understanding of the underlying molecular mechanism can influence specific treatments. As an example, a patient presenting with proximal nocturnal dyskinesia with mutation in the ADCY5 gene may respond beautifully to caffeine. Other examples if you have SLC2A1, so gluc-1 (glucose transporter type 1) mutation, a ketogenic diet may work really well. If you have PDHA1 mutation that may respond to thiamine and so on and so forth. There are certain patients where paroxysmal movement disorders are highly disabling and you may consider deep brain stimulation. That's another reason why it may be important to understand genetic mutations because there is literature on response to DBS with certain mutations versus others. Helps like counselling for patients and families, and of course introduces time, effort, and money spent in additional testing. Dr Nevel: Other than genetic testing, what other diagnostic work up do you consider when you're evaluating patients with a suspected paroxysmal movement disorder? Are there specific things in the history or on exam that would prompt you to do certain testing to look for perhaps other things in your differential when you're first evaluating a patient? Dr Mahajan: In this article, I provide a flow chart that helps me assess these patients as well. I think overall the history taking and neurological exam outside of these paroxysms is really important. So, the clinical exam in between these episodic events, for example, for history, specific examples include, well, when do these paroxysms happen? Do they happen or are they precipitated with meals that might indicate that there's something to do with glucose metabolism? Do they follow exercise? So, a specific example is in Moyamoya disease, they can be limb shaking that follows exercise. So, which gives you a clue to what the etiology could be. Of course, family history is important, but again, talking about the exam in between episodes, you know, this is actually a great point because out– we've talked about genetics, we've talked about idiopathic paroxysmal movement disorders, –but a number of these disorders are because of acquired causes. Well, of course it's important because acquired causes such as autoimmune causes, so multiple sclerosis, ADEM, lupus, LGI1, all of these NMDAR, I mentioned Moyamoya disease and metabolic causes. Of course, you can consider FND as under-acquired as well. But all of these causes have very different treatments and they have very different prognosis. So, I think it's extremely important for us to look into the history with a fine comb and then examine these patients in between these episodes and keep our mind open about acquired causes as well. Dr Nevel: When you evaluate these patients, are you routinely ordering vascular imaging and autoimmune kind of serologies and things like that to evaluate for these other acquired causes or it does it really just depend on the clinical presentation of the patient? Dr Mahajan: It mostly depends on the clinical presentation. I mean, if the exam is let's say completely normal, there are no other risk factors in a thirty year old, then you know, with a normal exam, normal history, no other risk factors. I may not order an MRI of the brain. But if the patient is 55 or 60 (years) with vascular risk factors, then you have to be mindful that this could be a TIA. If the patient has let's say in the 30s and in between these episodes too has basically has a sequel of these paroxysms, then you may want to consider autoimmune. I think the understanding of paraneoplastic, even autoimmune disorders, is expanding as well. So, you know the pattern matters. So, if all of this is subacute started a few months ago, then I have a low threshold for ordering testing for autoimmune and paraneoplastic ideology is simply because it makes such a huge difference in terms of how you approach the treatment and the long-term prognosis. Dr Nevel: Yeah, absolutely. What do you find most challenging about the management of patients with paroxysmal movement disorders? And then also what is most rewarding? Dr Mahajan: I think the answer to both those questions is, is the same. The first thing is there's so much advancement in what we know and how we understand these disorders so regularly that it's really hard to keep on track. Even for this article, it took me a few months to write this article, and between the time and I started and when I ended, there were new papers to include new case reports, case series, right? So, these are rare disorders. So most of our understanding for these disorders comes from case reports and case series, and it's in a constant state of advancement. I think that is the most challenging part, but it's also the most interesting part as well. I think the challenging and interesting part is the heterogeneity of presentation as well. These can involve just one part of your body, your entire body can present with paroxysmal events, with multiple different phenomenologies and they might change over time. So overall, it's highly rewarding to diagnose such patients in clinic. As I said before, you can make a sizeable difference with the medication which is usually inexpensive, which is obviously a great point to mention these days in our health system. But with anti-seizure drugs, you can put the right diagnosis, you can make a huge difference. I just wanted to make a point that this is not minimizing in any way the validity or the importance of diagnosing patients with functional neurological disorders correctly. Both of them are as organic. The importance is the treatment is completely different. So, if you're diagnosing somebody with FND and they do have FND and they get cognitive behavioral therapy and they get better, that's fantastic. But if somebody has paroxysmal movement disorders and they undergo cognitive behavioral therapy and they're not doing well, that doesn't help anybody. Dr Nevel: One hundred percent. As providers, obviously we all want to help our patients and having the correct diagnosis, you know, is the first step. What is most interesting to you about paroxysmal movement disorders? Dr Mahajan: So outside of the above, there are some unanswered questions that I find very interesting. Specifically, the overlap with epilepsy is very interesting, including shared genes, the episodic nature, presence of triggers, therapeutic response to anti-seizure drugs. All of this I think deserves further study. In the clinic, you may find that epilepsy and prognosis for movement disorders may occur in the same individual or in a family. Episodic ataxia has been associated with seizures. Traditionally this dichotomy of an ictal focus. If it's cortical then it's epilepsy, if it's subcortical then it's prognosis for movement disorders. This is thought to be overly simplistic. There can be co-occurrence of seizures and paroxysmal movement disorders in the same patient and that has led to this continuum between these two that has been proposed. This is something that needs to be looked into in more detail. Our colleagues in Epilepsy may scoff this, but there's concept of basal ganglia epilepsy manifesting as paroxysmal movement disorders was proposed in the past. And there was this case report that was published out of Italy where there was ictal discharge from the supplementary sensory motor cortex with a concomitant discharge from the ipsilateral coordinate nucleus in a patient with paroxysmal kinesigenic cardioarthidosis. So again, you know, basal ganglia epilepsy, no matter what you call it, the idea is that there is a clear overlap between these two conditions. And I think that is fascinating. Dr Nevel: Really interesting stuff. Well, thank you so much for chatting with me today. Dr Mahajan: Thank you, Kait. And thank you to the Continuum for inviting me to write this article and for this chance to speak about it. I'm excited about how it turned out, and I hope readers enjoy it as well. Dr Nevel: Today again, I've been interviewing doctor Abhi Mahajan about his article on diagnosis and management of paroxysmal movement disorders, which appears in the August 2025 Continuum issue on movement disorders. I encourage all of our listeners to be sure to check out the Continuum Audio episodes from this and other issues. As always, please read the Continuum articles where you can find a lot more information than what we were able to cover in our discussion today. And thank you for our listeners for joining today. And thank you, Abhi, so much for sharing your knowledge with us today. Dr Monteith: This is Dr Teshamae Monteith, associate editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in depth and clinically relevant information important for neurology practitioners. Use the link in the episode notes to learn more and subscribe. AAN members, you can get CME for listening to this interview by completing the evaluation at continpub.com/audioCME. Thank you for listening to Continuum Audio.

One course of antibiotics has the power to wipe out certain strains from your microbiome forever. Like everything in health, it's all about dose and right use, but when it comes to antibiotics we are reaching for it too causally without grappling with the real-world consequences. Unfortunately, Martha Carlin was unable to ignore them when it impacted her family in the most fundamental of ways. She has since become a master of gut health, and is serving the public and fight against chronic disease with offerings of the highest quality gut medicine possible. Martha Carlin is a systems thinker, entrepreneur, and founder of The BioCollective, whose journey began when her husband John was diagnosed with Parkinson's disease at age 44. Refusing to accept a future of inevitable decline, she applied her expertise in corporate turnarounds to uncover new approaches to managing and potentially altering the course of chronic disease. Her research  led her to recognize the central role of the gut, which she describes as the “general ledger” of health. In 2014, emerging science confirmed her insights, sparking her to leave her career and begin funding microbiome research at the University of Chicago with Dr. Jack Gilbert. Contact:Website - https://www.marthasquest.com/abouthttps://biotiquest.comJoin us as we explore:How her husband's “old person's disease” diagnosis changed Martha's life foreverHow to deploy specific bacteria strains for specific disease and wellness challenges using Martha's BiotiQuest ranges.How your poop quality and consistency can predict your risk of developing Parkinson's disease.Gut health myth busters - the hidden consequence of antibiotics use, the worst ones and why probiotics at your health shop are not what they seem to be.Mentions:Book - Missing Microbes, https://www.goodreads.com/book/show/17910121-missing-microbes Study - Peng X, Li J, Wu Y, Dai H, Lynn HS, Zhang X. Association of Stool Frequency and Consistency with the Risk of All-Cause and Cause-Specific Mortality among U.S. Adults: Results from NHANES 2005-2010. Healthcare (Basel). 2022 Dec 22;11(1):29. doi: 10.3390/healthcare11010029. PMID: 36611489; PMCID: PMC9818668.Person - Dr Hans Vink, https://glycocalyx.com/pages/about-usSupport the showFollow Steve's socials: Instagram | LinkedIn | YouTube | Facebook | Twitter | TikTokSupport the show on Patreon:As much as we love doing it, there are costs involved and any contribution will allow us to keep going and keep finding the best guests in the world to share their health expertise with you. I'd be grateful and feel so blessed by your support: https://www.patreon.com/MadeToThriveShowSend me a WhatsApp to +27 64 871 0308. Disclaimer: Please see the link for our disclaimer policy for all of our content: https://madetothrive.co.za/terms-and-conditions-and-privacy-policy/

Parkinson's disease is the fastest-growing neurological condition in the world—and according to Dr. Ray Dorsey, it doesn't have to be this way. In this episode, I sit down with Dr. Dorsey, a leading neurologist, Parkinson's researcher, and tireless advocate for rethinking chronic illness. Together, we unpack why the rates of Parkinson's have doubled in the last 25 years and explore a bold claim: Parkinson's is largely a manmade and preventable disease.Dr. Dorsey's message is urgent yet hopeful: prevention is possible, but it requires awareness, advocacy, and collective action. Dr. Ray Dorsey is a neurologist and one of the world's foremost voices in Parkinson's disease research and care. With deep clinical expertise and a passion for health care innovation, he is reshaping how we understand and address chronic illness. His parents were both psychiatrists, and he knew from first grade that he wanted to become a doctor. Today, he combines that lifelong love of learning with a mission to prevent Parkinson's and improve the lives of millions worldwide. ***  Subscribe to The Neuro Experience for more conversations at the intersection of brain science and performance. I'm committed to bringing you evidence-based insights that you can apply to your own health journey.  ***  A huge thank you to my sponsors for supporting this episode. Check them out and enjoy exclusive discounts: Troscriptions: Go to www.troscription.com/neuro | Code: NEURO for 10% your first order Ketone IQ:  Go to https://ketone.com/NEURO for 30% OFF your subscription order + receive a free gift with your second shipment. Caraway: Visit https://carawayhome.com/neuro and you can take an additional 10% off your next purchase. Manukora: Head to https://manukora.com/NEURO to save up to 31% plus $25 worth of free gifts with the Starter Kit. Rula: Go to https://rula.com/NEURO to get started today.  Puori: Go to https://puori.com/NEURO and use the code NEURO at checkout for 20% off. *** I'm Louisa Nicola — clinical neuroscientist — Alzheimer's prevention specialist — founder of Neuro Athletics. My mission is to translate cutting-edge neuroscience into actionable strategies for cognitive longevity, peak performance, and brain disease prevention. If you're committed to optimizing your brain — reducing Alzheimer's risk — and staying mentally sharp for life, you're in the right place. Stay sharp. Stay informed. Join thousands who subscribe to the Neuro Athletics Newsletter → https://bit.ly/3ewI5P0 Instagram: https://www.instagram.com/louisanicola_/ Twitter : https://twitter.com/louisanicola_ *** Learn more about Dr. Ray Dorsey's work: Ending Parkinson's DiseaseExplore Parkinson's 25 recommendations in his book The Parkinson's Plan to reduce your risk. Topics discussed: 00:00:00:00 —  Intro  00:01:45:16 — Rising rates of Parkinson's & preventability00:03:59:20 — How it starts & prodrome (decades-long progression).00:05:27:22 — TCE & contaminated water/sites (Camp Lejeune, Woburn, Brooklyn, Silicon Valley). 00:10:36:02 — Dry cleaning exposure (perc), apartments above cleaners. 00:12:31:08 — Pathophysiology I: mitochondria, substantia nigra, alpha-synuclein. 00:17:06:16 — Pathophysiology II: body-first vs brain-first; REM sleep behavior disorder.00:23:52:16 — Diagnosis: clinical features, imaging/biomarkers. 00:25:44:09 — Genetics (12.5%) & environmental susceptibility; TCE history/regulation. 00:29:12:23 — Pesticides: chlorpyrifos, paraquat; golf-course & agricultural exposure. 00:34:14:00 — Consumer guidance: wash produce; prioritize organic meat/dairy; contamination case studies. 00:37:58:11 — Sex differences & exposure sociology; possible estrogen protection. 00:39:37:03 — Management mindset: no cure; reduce exposures; 25 recommendations; occupational risks.00:41:05:15 — Air pollution & purifiers: PM2.5, blood–brain barrier bypass, home monitoring.00:46:53:17 — Water purification: filters vs RO; well-water testing & regulation gaps. Learn more about your ad choices. Visit megaphone.fm/adchoices

Matias interviews Rob Malenka, Chief Scientific Officer of Bayshore, the family office of Google co-founder Sergey Brin.  Bayshore has played a major role in advancing treatments for Parkinson's, bipolar, and autism. In this episode, we discuss:Why progress in psychiatry is slow because the brain is the most complex organ and many disorders are highly heterogeneousThe bottlenecks including weak replicability in research, academic politics, perverse incentives, and pharma's avoidance of neuropsychiatryHow breakthroughs require early detection, rigorous science, and bridging academia with biotech through venture philanthropyHow success depends on mission-driven, ethical people who align science, capital, and patient impact.The opportunities in neuromodulation, data-driven precision medicine, and combination therapies.Credits:Created by Greg Kubin and Matias SerebrinskyHost: Matias Serebrinsky Produced by Caitlin Ner & Nico V. Rey Find us at businesstrip.fm and psymed.venturesFollow us on Instagram and Twitter!Theme music by Dorian LoveAdditional Music: Distant Daze by Zack Frank

While there have been improvements in therapies to treat Parkinson's symptoms, people living with the disease and their loved ones await a treatment that will slow the progression of Parkinson's disease (PD) or stop it entirely. These therapies, called disease-modifying therapies, have the potential to change how PD is treated and experienced. Tune into audio from this Third Thursdays Webinar to listen to our panel of experts discuss disease-modifying therapies and the latest in Parkinson's research. Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0 Whether you have Parkinson's or not, you can help move research forward. Join the study that's changing everything at michaeljfox.org/podcast-ppmi. This webinar was produced with support from Biohaven. https://www.biohavenclinicaltrials.com/clinical-studies/parkinsons-disease/ Mentioned in this episode:The Foundation's landmark research study is exploring the connection between sense of smell and brain disease. People with and without Parkinson's can help by taking a free scratch-and-sniff test. Get yours at mysmelltest.org/request.

Parkinson's Disease affects around a million people in the United States. And that number is on the rise, in part because our population is getting older. Dr. Claire Henchcliffe, chair of neurology at the University of California, Irvine, is one of the scientists at the forefront of Parkinson's research. She's working toward new treatment options for Parkinson's, including recent discoveries about the potential use of stem cells. Science correspondent Jon Hamilton dives into this research — and even a future where scientists can prevent the disease altogether — on the show with Henchcliffe. Interested in more on the future of brain science? Email us your question at shortwave@npr.org – we may feature it in an upcoming episode!Listen to every episode of Short Wave sponsor-free and support our work at NPR by signing up for Short Wave+ at plus.npr.org/shortwave.Learn more about sponsor message choices: podcastchoices.com/adchoicesNPR Privacy Policy