Podcasts about Parkinson

Send us Fan MailMartha Carlin is not your typical founder. Driven by a deep love for people and the planet, she has emerged as a thought leader, innovator, and out-of-the-box problem-solver in the field of microbiome research. Martha's unique perspective connects the dots from soil to food to our guts and our brains, unraveling the complex web of connections that influence our health.What sets Martha apart is her heartfelt dedication to solving complex health challenges. Her unwavering commitment to understanding our evolving health issues has propelled her into the realm of citizen science, particularly in the microbiome and Parkinson's disease fields.Martha's journey is driven by applying her systems thinking approach to microbiome science and its potential to impact human health. Her husband John' s Parkinson's diagnosis in 2002 ignited a passion to delve deeper into causal factors like diet and lifestyle as well as holistic/alternative ideas that deserve further study. Years later the connection published research about the gut bacteria and the two phenotypes of Parkinson's disease was a Eureka moment.Inspired by this groundbreaking research from Dr. Filip Scheperjans in 2014, Martha founded The BioCollective, a research company focused on mapping health. Witnessing John' s improved symptoms while taking her product Sugar Shift solidified Martha's conviction to bring this transformative product to market, empowering individuals to take control of their health and providing a reliable source of knowledge to support their well-being.Find Martha at-https://biotiquest.com/Substack- @Martha's QuestFind Boundless Body at-myboundlessbody.comBook a session with us here! 

On this episode of WYCE's Community Closeup, host Phil Tower welcomes Leah Voigt, CEO of Grand Rapids Ballet, for a conversation about her new leadership role and the future of Michigan's only professional ballet company.Voigt previews the 2026–2027 season, including Broken Wings, The Nutcracker, Alice in Wonderland, Pinocchio, Jumpstart, and Fancy Free, while also discussing the Ballet's work beyond the stage through its school, Junior Company, adult dance classes, community outreach, and Moving with Parkinson's program. Our conversation also explores her priorities for growing audiences, expanding educational opportunities, strengthening community partnerships, and ensuring the organization's long-term sustainability.Learn more about Grand Rapids Ballet, the upcoming season, tickets, classes, and community programs at grballet.com.

Summer is a busy time for everyone, guests and listeners alike, so today we're taking stock. This is our Summer Recap — a clips episode pulling together the best moments from conversations you might have missed over the past few months.We'll hear from Randy Teel of Arvinas and Per Lundin of Evox on two very different ways of getting drugs to the brain, and Laurent Lévy of Nanobiotix on outsmarting the liver altogether. We'll meet the founders behind these companies, including Andy Parker of Step Pharma and Gene Mack of Gain Therapeutics, and the unlikely paths that got them there. We'll dig into the science of nonsense mutations with Nerissa Kreher of Alltrna, circular RNA with Lu Gao of Therorna, and a cancer target hiding in human genetics. And we'll close with what these leaders think success actually looks like, years from now.So sit back, and let's revisit some of our favourite moments from the summer.02:32 Solving the delivery problem08:39 Founder journeys15:13 Platform science24:41 Business, money, and geopolitics32:28 Looking aheadInterested in being a sponsor of an episode of our podcast? Discover how you can get involved here! Stay updated by subscribing to our newsletterTo dive deeper into the topic: Episode 204: The first PROTAC is here. What comes next in protein degradation?Episode 205: Turning cancer cell dependencies into targeted therapiesEpisode 208: Gain Therapeutics: a first-in-class, disease-modifying therapy for Parkinson'sEpisode 209: Why Western pharma is sleeping on China's circular RNA revolutionEpisode 211: Beyond biology: Nanobiotix's physics-first approach to cancerEpisode 213: How Evox Therapeutics is targeting CNS diseases with exosomesEpisode 214: Rewriting the rules of genetic medicine with tRNA therapeutics

This encore episode features a brief update to discuss some new medications that are currently being utilized to treat Parkinson's disease. By the end of this episode you'll have a thorough understanding of what you need to know about Parkinson's for your nursing school exams and NCLEX. Read the article "Parkinson's Disease NCLEX Review" and view references here. If you found this episode helpful, I've got lessons and comprehensive study guides on over 57 more topics in my course Med Surg Solution. Learn how Med Surg Solution can help you thrive in your Med Surg class (and on NCLEX!) here. This is a throwback to episode 198 of the Straight A Nursing School Podcast, where nursing school help is at your fingertips with hundreds of episodes covering your journey from taking the TEAS through passing NCLEX and having success as a new-grad nurse.

Learn more about Parkinson's and find support: https://dpf.org In part one of this two-part conversation from our Live Well Today webinar series, Davis Phinney Foundation's Chris Krueger sits down with Richelle Flanagan, a registered dietitian living with young onset Parkinson's, to discuss how protein interacts with levodopa and why meal timing affects how well your medication works, which key nutrients people with Parkinson's are most commonly deficient in, and why getting your levels checked matters. The conversation also covers iron and magnesium timing, protein redistribution, intermittent fasting, and fueling for exercise and fatigue. Richelle Flanagan is a registered dietitian with over 20 years' experience. She was diagnosed with Parkinson's in 2017, when she was 46, after noticing symptoms while 3 months pregnant with her daughter. In addition to her interest in diet and nutrition, she is passionate about the unmet needs of women with Parkinson's. She is a co-founder of the Women's Parkinson's Project and My Moves Matter, a digital health app to meet the specific needs of women living with Parkinson's. Second episode: Coming soon!! Learn more about Richelle's work at https://www.mymovesmatter.com Sign up for updates on webinars, events, and resources for the Parkinson's community: https://dpf.org/newsletter-signup

In this episode, I have the pleasure of speaking with Dr. Neil Nathan about the intersection between brain symptoms and complex illness. Dr. Nathan has practiced medicine for over 50 years. He is one of the leading experts in complex chronic illness and mold toxicity — author of the bestselling Toxic: Heal Your Body from Mold Toxicity, Lyme Disease, Multiple Chemical Sensitivity, and Chronic Environmental Illness and The Sensitive Patient's Healing Guide. I am grateful to call Dr. Nathan a mentor and colleague. His pioneering work has been responsible for my healing from chronic illness, as well as that of many patients I've treated. Together, we co-lead a small peer group (within the larger mentoring group he provides with Marie Matheson, ND), supporting practitioners who treat those with complex chronic illness.In this episode we discuss:03:43 – Dr. Nathan's path to understanding complex illness11:20 – Why complex illness is rising and underrecognized19:30 – Why new medical ideas take decades to reach patients23:15 – Mold, Lyme, and long-COVID: the “big three” root causes25:58 – The limbic-vagal-mast cell “trifecta”30:31 – Are some people born more vulnerable?44:39 – The risk in “just do limbic retraining” advice47:35 - Biochemical contributors49:26 – Structural root: jaw and cervical instability53:58 – Differentiating Between Mold, Lyme & Long-COVID58:49 – A message of hope, and where to learn moreFull Transcript belowYou can find Dr. Nathan's books, consultations and mentoring program through his website at neilnathanmd.com. If you'd like to help get this information out into the world, please consider liking, sharing, or commenting.Until next time,CourtneyCourtney Snyder MDDr. Courtney Snyder MD is a holistic and functional child and adult psychiatrist and host of the Holistic Psychiatry Podcast and can be found at courtneysnydermd.comMedical DisclaimerThis podcast is for educational purposes only and is not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment. Consult your own physician for any medical issues you may be having.Full TranscriptDr. Nathan's Path to Understanding Complex Illness03:43Courtney: I'm so glad we're doing this, and I feel like it's long overdue. As you know, in the mental health space in psychiatry, there's a lot of recognition of a dysregulated nervous system, threat response in the body, but oftentimes that's attributed to external forces or trauma, and not necessarily internal threats that we see, obviously, in complex chronic illness, which we'll be talking about. There's also not the recognition of the relationship between physical symptoms and brain-related symptoms. So I know you're going to help us connect a lot of these dots. As we sort of just lay the groundwork for what complex chronic illness is — when in your path did you start to recognize the distinction, when was the beginning of your work and appreciation of complex health issues?Neil: Okay, there are two answers to that question. First, when I went to medical school, my hope was to become a healer. And I was very disappointed that when I got there, I realized they weren't going to teach me to be a healer. And back then I used to question my professors at medical school — why do you do it this way, and how is that? And I kept feeling in all of our interactions that we were missing something. And my professors would go, “Okay, Mr. Wise Guy, smart guy, what are we missing?” And I'd go, “I don't know, I just know we're missing something.” Later I would come to recognize that we were missing the emotional and spiritual component to whatever was affecting people in their illnesses. And I have language for it now — I didn't then. The person in medical school who influenced me the most was Elisabeth Kübler-Ross, who I view as my main mentor in medical school. She, unlike anyone else, had a one-and-a-half-hour seminar once a week. Back then there weren't video cameras — you were in a small confined room with a two-way mirror, and you're sitting there watching someone do this. And she would simply interview one of her patients. She was a psychiatrist, but she was the only one in medical school who demonstrated how to really listen to people, how to really communicate with them, and not have this standard review of systems — here's my questions, here's your answers, and that's what I do, and this is what I write up. She was really listening. She was trying to really take in, okay, what happened to you, and what's going on with you? So I would want to give her credit as a role model to change how I learn to listen. Okay, that was step one.I'm going to fast forward to the early 1980s. And I am, at that point, the medical director of a regional pain clinic. And we are starting to see a whole bunch of patients who had this complicated process of fatigue, unrefreshed sleep, irritable bowel syndrome, and pain migrating all over their body. And back then we called it fibrositis. Now we call this fibromyalgia. And so whenever medicine encounters a thing that they don't know what they're looking at, it's psychological until proven otherwise. And people would get therapy, and they would take antidepressants and anti-anxiety agents. Didn't help much. And so it became clear to me that we didn't understand what this was at all. It was not psychological. Something was going on in their bodies — now I recognize it as an inflammatory process. Back then there was no concept of that at all. And then, slowly, in the early nineties, we began to find pieces of the puzzle to understand what was triggering fibromyalgia. I was working back then with Jacob Teitelbaum, who did a lot of work with chronic fatigue and fibromyalgia, and we both independently came up with an understanding that a deficiency of magnesium, DHEA, adrenal issues, thyroid issues, sex hormone deficiencies, GI dysbiosis, and food allergy — if we looked at those and treated those, the majority of people with fibromyalgia got cured. It was different for different patients. It was not like there was one thing that caused it. And as time evolved, we began to realize that there was lots of other biochemical imbalances in the body that would contribute to this kind of a process that represented chronic fatigue and fibromyalgia.We discovered that Lyme disease and coinfections was a huge piece of that. And later still we discovered that mold toxicity was a huge piece of that. And so my understanding of the complexity — and it's not really confined to chronic fatigue and fibromyalgia at this point, we're really talking about almost all chronic illness — with a huge psychological component to that. So we've begun to understand this as essentially some version of inflammation. And if we start to really dig into what are the potential causes of that inflammation, we can make a huge impact for them. So this is a multi-year evolving understanding of how a person's genetics, biochemistry, physiology impacts their whole being in every way. And that inflammation extends to the nervous system, contributing greatly, if not causing directly, a large number of what are now called psychiatric diagnoses.Courtney: Right. So even among those patients that you were seeing — you were seeing, I'm assuming, depression, anxiety, brain fog?Neil: Yeah, the vast majority of our patients with mold toxicity have brain fog and anxiety, depression, OCD behaviors, mood swings, depersonalization, derealization. I mean, all of that is super common in our patients.Complex Illness Is Rising — and Underrecognized11:20Courtney: Do you feel like this is more recognized now — or do you feel like the number of people being hit with these complex health issues is increasing — or both?Neil: Both. I would love to say that the medical profession is increasingly recognizing all of this as important, but that recognition is coming very, very slowly. The majority of folks out there, if they were to list the symptoms that they had, their doctors would basically look at them like, “I have no idea what's causing it, so this must be in your head.” And that is the message they're getting from their physicians at this point. So many patients are being gaslighted, so many patients are being told it's in your head. And the repercussions of that are the family is hearing that same message, and the families become less supportive of those people, because they're saying, “This is not real, so why would I support you? This is still in your head, go get your head fixed.” And they're wrong, and it's really a travesty. But so yes, very slowly, this awareness is growing. There are now more medical meetings that I'm aware of where psychiatrists can learn more about this than there were ten, fifteen years ago, for sure. But not enough — it's still not enough.The other part of that is some of the main triggers for this inflammatory process are increasing. So we're seeing more and more mold toxicity, we're seeing more and more Lyme and coinfections, partly because the environment that we are all exposed to has gotten extremely increasingly toxic. So it's now known, for example, that there are 350,000 new chemicals in our environment than existed 70 years ago. The vast majority of those have never been tested for safety in human beings. So human beings have a tremendous amount of chemical exposure that they never had before. Human beings have a tremendous amount of EMF, electromagnetic exposures that they never had before in the history of the human race. So these exposures are cumulative. Our major organs, like our liver and our kidney, that have to deal with toxicity, are overloaded. And so, yes, we are seeing an epidemic of a whole bunch of these conditions. In children, we are aware that autism has skyrocketed — it went from one in several thousand kids to one in thirty kids in many states now have autism. And forgive me, but the pediatric profession is not taking this seriously. It's like, “Yeah, that's sad, it's unfortunate.” It's like — really, you don't want to look at this? This means one in every three kids born are getting autism — does that not concern you? But, forgive me, the medical profession is very slow to embrace new information, and that is really to the detriment.We're seeing an epidemic of Alzheimer's, Parkinson's, ALS, all of which involve neuroinflammation. We've seen already an epidemic of chronic fatigue and fibromyalgia. And all of these things are interrelated, because — yes, I'm supposed to be an expert on mold toxicity, and I probably am — but mold toxicity doesn't exist in a vacuum. You have mold toxicity as one of multiple environmental toxins we're being exposed to. It is simply one of the most common, the easiest one to diagnose, because we have tests for it. We don't have tests for the hundreds of thousands of chemicals out there. We're just beginning to be able to have some tests that will tell us what's in someone's body that might be making them sick.Courtney: Right, right. And I would imagine that this typical medical model of looking for one cause to autism, one cause to dementia — it's a completely different way of thinking. When you get away from that and you look at complexity of the human body, that way of thinking holds back the research, it holds back any progress.Neil: What I think is helpful for people to look at is: we are all uniquely, biochemically, genetically different. And so the same inflammation in one person could trigger cardiovascular disease, and another person could trigger Alzheimer's, and another person could trigger chronic fatigue. So we need to take a step back and go, okay — and this is not a brand new idea. For the last ten years, there are many papers in the medical journals that are saying chronic illness is almost certainly an inflammatory process. Now, it hasn't really integrated into what people are being taught in medical school or in their residency program. But this is not a brand new idea, and there's tons of medical research documenting that.What behooves us as physicians is to look at every human being and go, “Okay, this is your named chronic condition — what are the triggers for you?” We have to kind of be like a medical detective and dig in and go, okay, what's triggering your inflammation, so I can treat the cause — not put a band-aid on it, which is, forgive me, in the psychiatric field, taking antidepressants and benzodiazepines. That's a band-aid. It's a helpful band-aid, it could be a very important band-aid, help someone to function. But you really need to be looking at, okay, I have this great band-aid, but wouldn't it be nice to actually cure this? And I think that would be, for me, to your audience, Courtney, my take-home message — which is always look for the root cause, because it is possible that we will find that root cause, and you won't have whatever name you've been given, depression, anxiety, OCD, for the rest of your earthly life. Maybe.And I've treated thousands of people successfully here. So this is not — I've had one or two successes here — we're talking thousands of people that have responded to this way of practicing medicine, with fabulous results. People who've been literally bedridden, incapacitated by their illness, are now out there working again and being with their family and living full lives. So that's the take-home message.Courtney: Right. Which makes it so satisfying to treat. And I mean, I can speak to that, having experienced it personally. But at the same time, you do get pushback from other areas of medicine that don't give it necessarily credibility, even though people, on the other side, are thriving and healing, and it's really amazing.New Medical Ideas & Research Take Decades to Reach Patients19:30Neil: You know, the history of all science, including medicine, is: new technology, new drugs are fast-tracked to get into our lives. Ideas, not so much. Typically it takes a generation — twenty, twenty-five years — for a new idea to come into acceptance. And the first reaction of any science, medicine included, is to get into denial, which is, “There isn't enough data to support this concept, and I can't be perceived as practicing bad medicine by embracing a concept that isn't proven yet.” But that means that all of their patients are going to have to wait twenty years — until suffering — until that person goes, “Now there's enough evidence, now I can learn how to do this, and now I'll begin to help you.” I'm not wired that way. I'm wired that if I have a suffering person, and I have something that I can offer them that might help, I'm going to try it. I'm going to do it in the safest way I know how, but I can't leave someone dangling for twenty years and say, “I'm sorry, I have to wait until my profession figures out what to do.” That's not me.I worked at the medical school at the University of Minnesota Duluth for eleven years. And I was not only on the faculty, but I was on the committee that determined what new information was put into the curriculum. For example, AIDS was just coming into vogue at that particular point, and it was obvious that we needed to have courses on AIDS for the medical students, because this was big. What a lot of people wouldn't understand is that each department in a medical school fiercely guards its time allotment. Everyone gets a certain number of hours, and they're not open to adding new things or giving up any of their time slots for anything new. And so what I would watch is, as new information came into the medical school, each department fiercely refused to add any new lectures in their department, or give up any of the time that they had to anybody else to add that information. So we're talking about university politics now — this is not even medicine, this is people guarding their turf. And I don't even think that would occur to any consumers, that that would happen like that — well, certainly, why would that happen in a medical school? Well, it's because human beings are responsible for each department, and they guard their own turf. So it's a kind of an insidious process about how new information isn't embraced by the profession, to go into the medical school curriculum.Mold, Lyme, and Long-COVID: The “Big Three”23:15Courtney: I want to come back to what you were saying about inflammation being at the core of chronic illness and complex chronic illness. And when it comes to complex chronic illness, whether it's SIRS or mast cell activation from mold or Lyme, we talk about multiple systems being affected — the central nervous system, gastrointestinal tract, endocrine, skin, just you name it. If the inflammation then is from a source of oxidative stress or a major insult — would you say that mold toxicity is the most common, or would you put Lyme or now even COVID on a par with that, as far as the deepest roots causing the inflammation? Not that the chemicals, metals, and everything else we're being exposed to aren't at play.Neil: In my experience, those three are the biggies — mold toxicity, Lyme with its co-infections, and long-haul COVID. Those are the three most common. Of those, in my experience, mold is the most common, and the one that has to be treated first if you have some or all of them. So, for example, in people who have long-haul COVID or Lyme, often their body will not respond to that treatment optimally until you first get the mold out. So there's a little hierarchy of what we do, in what order. And then within that hierarchy, there's also an order in which we do things for people to respond optimally. So, for example, mold toxicity will trigger — and Lyme and Bartonella will do the same thing — limbic dysfunction, vagal nerve dysfunction, and mast cell activation in most of our patients. Not all, but in most. And the longer they have it, the more likely those things are going to get triggered. Once somebody does not feel safe — and the systems that we have in our body to monitor that safety and to keep us safe are the limbic system, the vagal system, and mast cell activation — we have to get the body safer, or it will not be able to take what you need to take to treat mold or Lyme or long-haul COVID. People will literally shut down — their limbic system will essentially go, “Mm, I see what you're trying to do there, and I can't let you do it, because I'm not sure that's safe.” And it will literally not allow people to do it.The Limbic-Vagal-Mast Cell “Trifecta”25:58Courtney: So with one of those, or a combination of those, on board, these threat mechanisms would be kicked up — mast cell activation, limbic system dysfunction, autonomic nervous system dysfunction. If they look similar, or a timeline isn't easily helping parse out what might be primary, how able do you feel to make the distinction — versus if mold is present, starting there?Neil: If we look at our patient's symptoms, they will point us clearly to whether there's a limbic or vagal or mast cell piece, to be specific. The limbic system's job involves primarily monitoring and regulating and keeping emotion and sensitivity in check. So any symptoms that involve those two things are limbic almost by definition. So on the sensitivity side, if someone describes an increased sensitivity to light, sound, touch, smell, chemicals, EMFs, food — they're already telling me my limbic system is dysfunctional. In some ways it doesn't matter what the cause is; if someone has this increased sensitivity, regardless of the cause, I know we have to treat their limbic system first.On the vagal side, the symptoms would primarily run into symptoms that involve the autonomic nervous system, which would involve things like temperature dysregulation, palpitations, insomnia, POTS, blood pressure dysregulation, or symptoms that involve the gastrointestinal tract, because the vagus nerve controls almost the entire intestinal tract. So any GI symptoms — gas, bloating, distension, reflux, diarrhea, constipation, abdominal pain — again, that would lead me to go, the vagus is involved here. So by listening to my patient's symptoms, I can immediately know what's dysregulated here, and what my first treatment arm will be — to get the limbic and vagal systems back up and running again at a safer level, because otherwise our patients aren't going anywhere. They can do binders and antifungals and antibiotics for Lyme, and they will get worse. Their body will basically go, “I know I might need that, but why are you doing that? I can't even get to a place of safety to respond. I'm on self-preservation mode here.”And in the mast cell category — again, all of the same symptoms that could be mold or Lyme or long-haul COVID could also be mast cell. Again, it's a multi-systemic process. A tip-off, which I find very helpful, is if someone describes a symptom that comes on immediately after eating, sometimes while eating. Nothing causes that kind of reaction that fast except mast cell activation. Allergy — and most people, if they do have some symptom that comes after eating, they're going to be thinking, “It must be what I ate, what did I just eat?” But it's not food allergy, it's mast cell activation. In that context, many of our patients have already observed that they can eat a particular food one day and have a very strong reaction, and the next day, same food, nothing. And they'll go, “That doesn't make sense — if this was allergy, I ought to react the same way every time.” And so that is classical mast cell activation, which fluctuates. So — for the first part of your question — that's what I'm looking for. When I take a history, when I talk with patients, I'm going to really dig into: are they already manifesting symptoms that clearly tell me what we need to do first, to get them safer, so that now they can respond properly to the treatment that will really get at their root cause.Are Some People Born More Vulnerable?30:31Courtney: I know you take deep timelines when you meet with someone, so you're really accounting for a lot. But one of the things that I think about a lot is: who is most vulnerable? Do some of us come into the world already with a vulnerability similar to Elaine Aron's highly sensitive person model? And then maybe there's trauma, early attachment disruption — and already vulnerabilities — but then the toxic load that we're all experiencing. But then something like mold or Lyme then hits. And then, all the years and all the patients you've seen — I'm curious how many you feel already had sort of a vulnerability. Not that they ever had to really become sick necessarily, but already had a vulnerability.Neil: Honestly, I would say most. Our limbic system evolves from the time we were in our mother's uterus, so that almost no one has had a perfect childhood. And so whatever someone has had to deal with in childhood — it could be recurrent ear infections or throat infections, or it could be a surgical procedure, or it could be parents, both of whom worked and they didn't get enough time, or they could be abusive parents, sexually, physically, verbally abusive — whatever someone has been exposed to, that forces their limbic system to have to deal with it. Because that's the job of the limbic system, is to keep you safe. So your limbic system is basically going, “Okay, I'm just a little thing here, what do I need to do to cope with this?” And so their limbic system slowly, inexorably, becomes more and more hypervigilant to protect them. Let's say someone had an alcoholic parent, and they would come home, and you were never sure what their status would be — and so you'd kind of hold yourself back from that, which is, “I've got to see what this person is showing me, is it safe for me to come up and give them a hug, or do I want to hang out in my room for a bit until whatever this is settles down?” That's the beginning of this limbic hypervigilance process. And then it just goes on through life. So that if you've had difficult relationships, or surgeries, or severe infections, or anything in the physical or emotional or spiritual plane, a betrayal of some type — the limbic system becomes slowly more and more and more hypervigilant, when the straw hits the camel's back. And that straw could be COVID, or Lyme, or mold toxicity, or another infection of some type — that's the straw that breaks the camel's back. At that point the limbic system goes into shutdown, which — we know the vagal system goes into shutdown, literally, that's something the vagal system is trained to do. It's “okay, we are so unsafe that I'm shutting down my systems here.” And so that predisposes to illness. But I want to tie that back to inflammation, which — a lot of people don't understand that the vagus nerve, for example, controls inflammation in the body also. There are branches of the vagus that go to the spleen, to the gut-associated lymphoid tissue, and to the thymus, all of which are major immune organs. And if the vagus is dysfunctional, inflammation can rage out of control. So again, this comes back to understanding this complexity of inflammation, and how we need to both understand it and know where it is we want to look to get at that inflammation. So there is a profound interconnected limbic-vagal-mast cell piece. Each totally connects to the other. There's an interaction between the thousand biochemical mediators that mast cells make and the nervous system itself. So I call this interconnection the trifecta, which is: you can't just treat the limbic system in a vacuum, because if you're not also looking at the vagal and mast cell system, your treatment may be a little bit helpful, or it might not even work at all, until you combine all three — so that you really understand this is a package deal here, in terms of how we work with it.There was one more piece I wanted to add, Courtney, to understanding the inflammation piece: whether or not someone gets mold toxicity or Lyme or COVID depends on how robust their immune system is. So you could have a family living in a moldy environment — one person is really sick, several are a little bit sick, and one is not sick at all. And the one who's not sick at all can easily go, “I'm not sure what's wrong with you all, but I'm fine in this environment, it can't be my environment because I'm fine.” And what they're not understanding is: yes, they are fine, as long as their immune system stays robust. For the others, they were at risk for all of these conditions because their immune system took a hit. And for many people who were living in a moldy environment, during COVID, for example, when we isolated and people were spending twenty-four hours in their home rather than the eight hours out, they were many now being exposed to more mold at home than they were before. I don't think people began to think about that or look at that. So in that environment, whether or not they were affected depends on the hit they took. Now, the things that will hit an immune system to weaken it, and allow whatever's there to manifest, are: COVID was a biggie, any severe infection, a surgical procedure, childbirth, menopause, or any emotional upheaval will weaken that immune system, and then the immune system loses containment, and now we are off to the races. So what I try to convince people who are living in a moldy environment who are well is that they're living with a ticking time bomb. Should they take an immune hit, they will be just as sick as their family member who they're kind of lording it over, which is, “I'm not sick, what's wrong with you?” You'll be right there yourself if you take that hit — to try to help them understand, yeah, you're okay for now, but once your immune system weakens. So I'm trying to tie together the immune system, its ability to regulate inflammation, and this whole process here.Courtney: Right, right. Which I guess is why we call it complex, complex illness.Neil: It is the way human beings are. We're not making up a new word of complex illness — illness was always complex. We're just beginning to understand how complex it always has been.The Limits of Treating Symptoms Alone44:39Courtney: Right, so there's communities out there addressing mast cell activation. There's communities out there addressing POTS and dysautonomia. Communities out there addressing OCD and more obvious limbic-type issues. And then there's the whole mental health field. And the dots aren't getting connected. I mean, I've yet to see someone with OCD — I think it's like eighty to ninety-five percent have mold toxicity as part of the picture.Neil: You know, an example — and I won't name names — is there's an eminent pediatric physician who is very well known for his work in autism, who thought he was ADD his whole life until he recognized that he had mold toxicity and started taking antifungals, and all of a sudden his brain went online and he doesn't have it anymore. So that's just a very clear example of what you're talking about. And what we are talking about is: it's absolutely essential that all people who work in the medical field, all healthcare providers, embrace this complexity, because if you're only working on a piece of it, you will help some people to a certain extent, but you will not help people optimally. I mean, that is the absolute bottom line.The understanding that mast cell activation was huge came in 2016, when Larry Afrin wrote his book, Never Bet Against Occam. It was a huge game changer. When I read his book, it was like, “My goodness, I've been missing this in my patients.” And the whole world embraced this information, so that every medical center in the country now has a mast cell activation clinic. However, they're looking at it as a single thing with a label to it, and they're treating it just that way. They have not recognized that if they don't add limbic and vagal work to it, their treatment is not going to be adequate. And so, yes, they're helping people, but absolutely not optimally. And to make it worse, very few of those clinics have recognized that what's causing mast cell activation, which absolutely needs to be treated, is mold toxicity and Lyme. So people go to these clinics and get a certain amount of help, but they're not being treated comprehensively, which is a pet peeve of mine — which is, come on, if you're going to have a clinic, understand the whole interactions of whatever name it is you're working with. If you're going to be an ENT specialist, understand everything that impacts that area. If you're going to be a cardiologist, understand everything that impacts it. And we just don't see that. We see people kind of in their little box — “No, no, I've learned this, this is what I do, this is how I work” — and it's just unfortunate that they're not looking at the bigger picture.Courtney: Right, I think add to that PANS and PANDAS, because in psychiatry, people feel like they're deep diving because they're getting to PANS and PANDAS. It's like, okay, you've got to go deeper than that, because even those conferences, they talk about the need for treating relapse, and it's just going to keep reoccurring.Neil: I mean, they're using IVIG to help. That's nice, but they're not getting to cause. And we know when PANS and PANDAS first emerged on the scene, it was all about strep, and that was the focus for a long time. But as time emerged, it was very clear that this was a neurological inflammation triggered — here we go, broken record — Lyme, mold, other infectious agents had to be looked for. And if we treated those, you could cure PANS. It wasn't something that needed IVIG for the rest of your earthly life.Courtney: Even among those, would you say very often mold is underlying the mycoplasma, the candida?Neil: I think mold is one of the most missed components to illness that I can think of. If I have a goal in life, it would be to raise the consciousness of our profession as to the importance of mold toxicity, how common it is. We're talking millions and millions of people who are not diagnosed, because their doctors don't know about it, and therefore are not making the diagnosis. I'd love to see the consciousness get to the point that someone would present with these complicated stories and a doctor would say, “Why don't we think about mold toxicity?” That would be the most important thing I would have done in my career.Courtney: Yeah, well, you're certainly raising awareness.Neil: I'm working — it is slow. As we said, I'm working on a twenty-year generational issue here.Courtney: You've mentioned that the underlying source needs to be addressed, but the nervous system and immune systems need to be addressed. So one of the things that comes up with limbic system retraining is: I've had people hear the message that if they just address their limbic and autonomic nervous system, then they wouldn't need to address what I see as an ongoing threat, such as a mold toxin. So I'm hoping you can speak to that, and the importance of these programs, despite that.Neil: Sure. A couple of the better-known limbic retraining programs, the coaches get a little bit zealous about — “limbic retraining is so important, this is all you need to do alone, don't even do anything else, just do limbic retraining.” And I suspect that there are a handful, very few, but a handful of people who've gotten well just doing limbic retraining. If, for example, if you had mold toxicity, if it was relatively new, if you had not colonized, and you moved out of your mold exposure soon, it is possible that the limbic retraining would help reboot it to the point that your immune system rebooted itself and you'd be fine. I believe there are a few people like that. The vast majority of people who have limbic dysfunction — you need to do limbic retraining and vagal retraining. You may also need to do mast cell retraining, and please look for the cause of that. Those are downstream effects, those are not named diagnoses that you treat alone and it fixes it. Please look for at least mold and Lyme, which are the two most common things that are triggering this at this point. And people are getting the wrong message if they think they need to do it in a vacuum. To make it worse, they're being told, “No, no, just do limbic retraining, that's all you need.” And the truth is, no, you need to combine limbic retraining and vagal rebooting and mast cell activation most of the time. And of course you've got to get back to cause.Courtney: Right, I mean I try to liken it to — if they were in an abusive relationship or toxic relationship, they wouldn't just limbic-system their way out of that, if there was an external threat.Biochemical Contributors47:35Neil: No, you've got to fix what's primary here. I want to add to this discussion — we're focusing on inflammation from toxins and infections, but there are also other biochemical issues, some of them downstream, that need to be looked for and addressed in order for people to recover completely. So, for example, Lyme and mold will trigger kryptopyrrole issues, or imbalances in the ratio between zinc and copper, or they'll trigger methylation issues super commonly. And I just wanted to expand this discussion — I know it's complicated enough, but I don't want to oversimplify it either — that there are other biochemical things that we want to be looking for, because they're treatable, and they will help people to heal faster, if we're also addressing methylation, the need for zinc, the need for magnesium or B6 — those are common components of this whole process here. And so I just want to kind of tie that all together for a moment.Courtney: No, I'm glad you did, because those are topics that I talk about here, so it's important to connect those. The other thing I see, because I integrate the Walsh approaches with treating people that have complex health issues, is zinc seems so amazing when it comes to mast cell activation — making sure that's optimized. As well as connective tissue — and that was something else I wanted to ask you about — is structural issues that can be impacting the autonomic nervous system. I just see a lot of people — I inquire about it because I had it myself — but who have upper cervical instability as part of this whole picture.Structural Contributors49:26Neil: Again, all of these things are interrelated, and the physical structure can prevent people from moving forward in several different ways. One is the structure of the jaw and the face — the body puts a priority on teeth occluding properly. And if the teeth don't meet just quite right, and the jaw is a little bit out of structure, people often talk about TMJ — the body basically freaks out, it goes into sympathetic overdrive. And for some patients — it's not common, but I've seen several dozen — where the jaw had to be realigned by a combination of dentists specially trained in this work, working with osteopathic physicians, to realign the jaw. Often in those patients, they couldn't respond to the limbic and vagal treatment until their jaw got realigned.Same thing is true with what you're talking about, as cervical cranial instability, which is basically a weakening of the ligaments at the base of the skull, where it attaches to the first cervical vertebra. Now, these are all again intertwined — for example, it begs the question of what weakens those ligaments. And the answer is: if you have mast cell activation, some of the materials that the mast cell makes weakens the ligaments. So the ligaments get weak, and where the skull attaches to the first cervical vertebra, instead of being pulled apart, like ligaments do, it collapses. And that influences the blood flow to the brain, the nerve flow to the brain. And again, the body recognizes that as a priority, and often you can't get that better — you can't get limbic and vagal response until that gets fixed.So there are a bunch of structural issues that also need to be looked at, when people become overly sensitive and are not responding properly. And there's more in that area. So, for example, there's a chapter by Tasha Turzo, who's an expert on the jaw structure. There's a chapter in there by Andy Maxwell on cervical cranial instability. So that book would give people a really good overview of how complicated things are, and they might, chapter by chapter, get a clue of, “I haven't looked at this piece yet.” I mean, we haven't talked about oxalate or salicylate imbalances, which can add to that. So I just think that is a resource for folks that could really help them understand how they've gotten where they are, and understand the path out.Courtney: Right, right, because not everyone has all of these areas, but certainly could be held back or have a unique something that they could be getting relief from early on in the process. So I think it's both, to the degree that people are able to learn, and your book Toxic, too — it's like an encyclopedia, even if someone doesn't read straight through it, they can go to the mast cell section, or they can go to the Bartonella section.Neil: It was intended to be a readable way to understand this complexity, because it basically will talk about almost everything we've talked about today, and help people to get better understanding. I mean, we've talked about the bigger picture today. We didn't talk about, okay, how do you diagnose Lyme, how do you diagnose mold toxicity, how do you diagnose long-haul COVID, and most important, because this is very complicated, how do you decide which of those is the biggest player that you want to address first?Distinguishing Between Mold, Lyme & Long-COVID53:58Courtney: Right, I have shared resources on diagnosing mold toxicity. Would you comment on your last point — how do you recognize, are you using specific testing that you want to reference, the RealTime?Neil: I do. But I would emphasize, we're taught in medical school that if you really listen to patients, ninety-five percent of the time you will make the diagnosis by history alone. And I don't want to get too focused on testing, because listening to the patient and having them describe in detail what they're going through will really give you the little pieces you need to tease it apart to a certain degree. That's only possible to a certain degree, because there's a huge overlap between the symptoms of Lyme and Bartonella and mold and long-haul COVID and mast cell activation. Huge overlap. So there's little teeny pieces that will tend to lean more in one way than another. And honestly, that's what's required from all of us, literally years of study, to really get a handle on — someone will say something, okay, that's much more of a mold symptom than it is a Lyme symptom, something else. So I do encourage people, if they think they might have mold, to get a urine mycotoxin test. That has revolutionized our ability to make these diagnoses.Courtney: Would you still set RealTime as the preferred? That's what I've communicated to this audience.Neil: I would. Any test can help make the diagnosis, but for follow-up testing, the only one that's been really consistent is RealTime. And you want a follow-up test, so you want to know what your baseline starting is, and then you want to know, okay, am I getting these toxins out of my body? From my perspective, you know that you're done treating it when that RealTime comes back reading not present in every category. We have better tests now for Lyme than we've had in the past. Years ago, our tests were inadequate to say the least. And the CDC recognized years ago that the tests were so inadequate that it was basically a diagnosis made by a physician by examining all of the history and information that you had. That was enough — you didn't need a lab report to make the diagnosis of Lyme disease. A new test that I'm particularly fond of is Bruce Patterson's fourteen-panel cytokine test. This is a test that measures cytokines, which are the molecules of inflammation — cytokines are made by your immune system to deal with, or fight, different inflammational causes. And so what Dr. Patterson has discovered is there's a pattern of cytokines that we see with long-haul COVID, which is different than the pattern we see for Lyme. And I'm working with him now on the pattern for mold. So we can literally look at that test and look at, okay, what is inflaming this person primarily now, because I'm looking at that inflammational pattern, and I can literally read that. Some of my patients will have all of those on a particular test, or only one, but it really helps tease apart what is — I call it public enemy number one for my patient, what do I need to address as root cause right now. So our science is improving as we go here.A Message of Hope — and Where to Learn More58:49Courtney: And that's huge. Before we go — I think all of your books, but I'm thinking specifically about Toxic and The Sensitive Patient — all the information you generously share gives people a lot of hope who've been struggling out there. And I think your mentoring and teaching so many of us helps extend some of that reach. Is there anything you'd want to convey to people out there in the throes of chronic illness who are feeling hopeless and not getting the feedback from their doctors that this is something they can get beyond?Neil: Sure. My take-home message is always: everything we talked about today is treatable. Is there hope in there? You bet there is. But if you are not getting the help you need from whoever you are seeing, find someone who understands these things. For example, I do have on my website a list of physicians that I've trained over the years that I'm comfortable that they really know what they're doing — it's a growing list. There's someone like Courtney, who's been trained for years to do this, she's good at it. Find someone who knows what they're talking about, so that you can get someone who does embrace this complexity, and will look at it in its entirety, and then get you moving in the right direction, doing the right things in the right order. To me, this can be done. I mean, I have personally helped to cure four or five thousand people with mold toxicity, and an equal number of people with Lyme disease. So we can help the vast majority of people that we're seeing. So, regardless of how long you've been sick, if you haven't been properly diagnosed and you haven't gotten the right treatment, you can be helped.Courtney: Right, right, that's great. And for physicians out there who are interested in learning more about complex chronic illness — are there resources you would point to? I'll be sharing your books, because I think those are great references — but also how people can find what you're doing currently.Neil: Sure, my books — particularly with this discussion, Toxic and The Sensitive Patient's Healing Guide would be the two most appropriate. I would add that I have just finished writing a book on this whole subject of inflammation. It's currently being edited, I hope it'll be out by early next year. So if you stay tuned to my website, I'll let people know when that's going to be available. And I think, Courtney, what you're referring to is: I do have a mentorship program for healthcare providers. We now have three hundred and fifty-plus people in the mentorship program, it keeps growing. You were in one of the first groups — we started with eight, and then people kept wanting to get in on it. So we welcome people to join. If you go to my website, which is simply neilnathanmd.com, there's a whole thing which talks about the mentorship and how to sign up for it. So I certainly welcome people who want to learn more.Courtney: And then you offer consultations and professional consultations also?Neil: I do. My consultations — I am, at this point, since I'm semi-retired, not seeing people directly. But I do offer consultations with a patient and their primary treating physician — so we all get on a Zoom together, and we will go over the details of that person's history and their lab work, and I will help outline a treatment program that looks to me like it will get people well. And actually, Courtney, I actually do a lot of that — I'm not really retired, my wife will tell you. I stay pretty busy. I love helping people. I love being able to take this complicated information and tease it apart, so that I can help people to understand what they need to do, in what order, in order to get better.Courtney: And we're all grateful — grateful that you've followed your path, because so many people have benefited personally and professionally. So thank you for bringing your wisdom and expertise, really appreciate it.Neil: You're very welcome, happy to do that.You can find Dr. Nathan's information, consultations, and mentoring program through his website at neilnathanmd.com. If you'd like to help get this information out into the world, please consider liking, sharing, or commenting.Until next time,CourtneyCourtney Snyder MDDr. Courtney Snyder MD is a holistic, functional, and environmental psychiatrist for children and adults. Find her at courtneysnydermd.com and on the Holistic Psychiatry Podcast on all major platforms.Medical DisclaimerThis podcast is for educational purposes only and is not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment. Consult your own physician for any medical issues you may be having. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit courtneysnydermd.substack.com

Dylan Griffiths, Malcolm Allen ac Owain Tudur Jones sy'n ystyried os ydi rheolwr Cymru Craig Bellamy wedi tawelu'r amheuon wrth ymateb i gwestiynau am ei drafodaethau efo Burnley. Roedd yna "ddiffyg parch" gan Bellamy yn ôl Malcolm, tra bod Owain yn credu bod yr holl broses yn rhywbeth cyffredin iawn yn y byd pêl-droed.Un peth anghyffredin iawn, serch hynny, ydi'r pwysau mae rheolwr Wrecsam Phil Parkinson yn ei deimlo ar ôl cychwyn hynod siomedig i'r tymor, gafodd ei amlygu gan y grasfa o 6-0 yn West Ham. Fydd y perchnogion hyd yn oed ystyried diswyddo'r rheolwr o gofio ei holl lwyddiant?Ac mae dannedd Malcolm yn creu trafferth iddo unwaith eto, ac yn peryglu diogelwch Dylan!

This episode of Talking Parkinson's Research focusses one of the most common and troubling non-motor symptoms facing people with Parkinson's - problems related to sleep. Quality of life is so impacted that many rate if as their number one research priority. We were delighted to welcome one of the UK's leading researchers in the field of sleep, to our virtual studio to hear about his ground breaking work. Dr Ian Harrison, a Principal Research Fellow at UCL, has been investigating the mechanisms of sleep in neurodegenerative diseases, in particular the role of the glymphatic system, which may also be implicated in the progression of Parkinson's.   

Was this the first enjoyable Jets' win in years? Host of the "Turn on the Jets" podcast, Will Parkinson says it was good to see the Jets win and dominate on Sunday. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Send us Fan Mail "The brain actually can regenerate given the right information. You first remove the obstacles to cure through testing, and then you layer in the correct sound, light, and regenerative stem cell therapeutics to allow the body to heal itself." — Dr. Greg Eckel Can the human brain actually heal and regenerate after severe neurological decline? Mainstream medicine often says no, but Dr. Greg Eckel is clinically proving otherwise.In this powerful episode of The Remarkable People Podcast, host David Pasqualone sits down with naturopathic physician and Chinese medicine practitioner Dr. Greg Eckel. Following the heartbreaking loss of his wife Soraya to Creutzfeldt-Jakob disease (CJD), Dr. Eckel dedicated his life to answering one central question: How do we regenerate the human brain?Dr. Eckel breaks down the three main causes of protein misfolding (Environmental Toxicity, Trauma, and Infections), reveals the early warning signs of neurodegeneration that most people ignore (like loss of smell and chronic gut issues), and explains his groundbreaking Eckel Protocol—utilizing frequency sound baths, targeted light therapy, and laser-guided stem cell therapeutics to restore cognitive function. Plus, discover the #1 food you must eat daily for brain health and the #1 neurotoxin you need to eliminate immediately.Call to Action Links:Learn more about Dr. Greg Eckel's work: Be Vital Clinic / Nature Cures ClinicSupport the show and get the best sleep of your life: Visit MyPillow.com and use promo code REMARKABLE for free shipping on your entire order and up to 80% off!Support the showTHE NOT-SO-FINE-PRINT DISCLAIMER: While we are very thankful for all of our guests, please understand that we do not necessarily share or endorse the same beliefs, worldviews, or positions that they may hold. We respectfully agree to disagree in some areas, and thank God for the blessing and privilege of free will.For more Remarkable Episodes, Inspiration, and Motivation, please visit https://davidpasqualone.com/remarkable-people-podcast/ now!

What happens when Parkinson's changes nearly everything you love to do? For Paul and Deanna Stroud, music became an unexpected path back to purpose, connection and joy. In this episode, the Strouds talk candidly about Parkinson's, grief, caregiving and the losses that come with changing abilities. They also share how the Second Verse Choir, a program for people living with dementia, transformed Paul's outlook and gave him something to look forward to again. For Paul, music gave him something to look forward to. Rehearsals restored a sense of purpose and belonging, while singing familiar songs created opportunities for connection and engagement. At a time when Paul had been struggling deeply with his sense of meaning, the choir helped him reconnect with life.  More about Second Verse here: www.secondversechoir.org.    Giving Voice is another resource for starting a choir in your own community: www.givingvoicechorus.org.    For more information on AgingIN education opportunities: https://aginginnovation.org/solutions/education/ 

What might carbon monoxide be doing in the brain that could potentially protect against Parkinson's?

9/16/26, Co-Host Brian Adams Dr. David Gottsegen: diagnosing, treating and living with Parkinson's. Also, the immunizations you and your kids need now. UMass Professors Margaret Stratton (Biochemistry) and Eric Strieter (Chemistry) —their new $1.3 million grant to search for the protein in your brain that makes memory --how your memory in yr brain works. Evolutionary Biologist from the Woods Hole Oceanographic Institute, Carolyn Tepolt, on invasive species and what do about them — turn green crabs into whiskey and delicious sauce? Democracy at a Crossroads: History, Power, and the Fight Ahead: A Conversation with Ken Burns https://movement.vote/register/8ky1p1vt/ with Larry Hott—a preview of their conversation and the Movement Voter Project event this evening.

9/16/26, Co-Host Brian Adams Dr. David Gottsegen: diagnosing, treating and living with Parkinson's. Also, the immunizations you and your kids need now. UMass Professors Margaret Stratton (Biochemistry) and Eric Strieter (Chemistry) —their new $1.3 million grant to search for the protein in your brain that makes memory --how your memory in yr brain works. Evolutionary Biologist from the Woods Hole Oceanographic Institute, Carolyn Tepolt, on invasive species and what do about them — turn green crabs into whiskey and delicious sauce? Democracy at a Crossroads: History, Power, and the Fight Ahead: A Conversation with Ken Burns https://movement.vote/register/8ky1p1vt/ with Larry Hott—a preview of their conversation and the Movement Voter Project event this evening.

9/16/26, Co-Host Brian Adams Dr. David Gottsegen: diagnosing, treating and living with Parkinson's. Also, the immunizations you and your kids need now. UMass Professors Margaret Stratton (Biochemistry) and Eric Strieter (Chemistry) —their new $1.3 million grant to search for the protein in your brain that makes memory --how your memory in yr brain works. Evolutionary Biologist from the Woods Hole Oceanographic Institute, Carolyn Tepolt, on invasive species and what do about them — turn green crabs into whiskey and delicious sauce? Democracy at a Crossroads: History, Power, and the Fight Ahead: A Conversation with Ken Burns https://movement.vote/register/8ky1p1vt/ with Larry Hott—a preview of their conversation and the Movement Voter Project event this evening.

9/16/26, Co-Host Brian Adams Dr. David Gottsegen: diagnosing, treating and living with Parkinson's. Also, the immunizations you and your kids need now. UMass Professors Margaret Stratton (Biochemistry) and Eric Strieter (Chemistry) —their new $1.3 million grant to search for the protein in your brain that makes memory --how your memory in yr brain works. Evolutionary Biologist from the Woods Hole Oceanographic Institute, Carolyn Tepolt, on invasive species and what do about them — turn green crabs into whiskey and delicious sauce? Democracy at a Crossroads: History, Power, and the Fight Ahead: A Conversation with Ken Burns https://movement.vote/register/8ky1p1vt/ with Larry Hott—a preview of their conversation and the Movement Voter Project event this evening.

BioVie CEO Cuong Do joined Steve Darling from Proactive to discuss what the company believes is a significant breakthrough in the treatment of long COVID, reporting that its lead drug candidate, Bezisterim, became the first therapy to demonstrate improvements across the three hallmark symptoms of the condition—fatigue, malaise and brain fog—in a well-controlled clinical trial. Do noted that the National Institutes of Health (NIH) RECOVER Initiative has supported eight clinical studies evaluating 13 different interventions for long COVID, yet none have demonstrated meaningful effectiveness to date. Against that backdrop, he said BioVie's results stand out as an important milestone in the search for therapies targeting the complex and often debilitating condition. According to Do, the trial delivered three major insights into long COVID and how it may be treated. First, the study confirmed that long COVID is highly heterogeneous, meaning patients experience symptoms very differently. Only about 15% of participants entered the study with severe levels of all three major symptoms, while roughly 20% were not significantly affected by any of them. Second, the data showed that patients must have a meaningful level of symptom severity at baseline in order to demonstrate measurable improvement. This finding may help guide future trial designs and patient selection strategies. Third, and most importantly, patients with a high symptom burden experienced clinically meaningful and statistically significant improvements. Participants suffering from severe fatigue saw improvements in fatigue-related measures, those with pronounced malaise experienced gains in both malaise and cognitive function, and patients with severe brain fog demonstrated measurable improvements in cognitive impairment endpoints. Looking ahead, Do said BioVie expects biomarker data from the study within the next several months. The company hopes those results will provide further insight into the biological mechanisms behind Bezisterim's effects and help validate the therapeutic approach. Following the biomarker analysis, BioVie plans to request an end-of-Phase 2 meeting with the U.S. Food and Drug Administration to discuss the design of a Phase 3 trial. The company is also pursuing grant funding opportunities to help support the next stage of development for its long COVID program. Beyond long COVID, BioVie continues to advance Bezisterim as a potential treatment for Parkinson's disease. Do said the company has been working closely with clinical experts to finalize the design of a registrational Phase 3 study and believes it has identified the appropriate endpoints, study size and duration needed to demonstrate the drug's potential to address both motor and non-motor symptoms of Parkinson's. He added that Bezisterim could potentially become the first therapy capable of not only improving symptoms but also modifying disease progression. BioVie expects to receive formal FDA feedback on its Phase 3 Parkinson's trial design before the end of the year. proactiveinvestors #biovieince #nasdaq #bivi #Bezisterim #LongCOVID #Healthcare #Biotech #ClinicalTrials #BrainFog #Fatigue #MedicalResearch #ParkinsonsDisease #DrugDevelopment #FDA #Biotechnology #LifeSciences #HealthcareInnovation

Dr. Matthew Phillips is a neurologist and researcher studying metabolic therapies for Alzheimer's, Parkinson's, ALS and glioblastoma.Show partner:Paleovalley - Save 15% off your first order by using this linkShow notes:jessechappus.com/722

Long-term residential exposure to the insecticide chlorpyrifos was associated with more than a 2.5-fold higher risk of developing Parkinson's disease, adding to growing evidence that certain pesticides may pose a significant risk to brain health Researchers strengthened the findings by showing that chlorpyrifos produced similar Parkinson's-like changes in laboratory animals (via mice exposed by inhalation over 11 weeks), including loss of dopamine-producing nerve cells, harmful protein buildup, and chronic brain inflammation The pesticide disrupted the brain's natural recycling system in these animal models, allowing damaged proteins to accumulate inside nerve cells instead of being cleared away, which may help explain how exposure could contribute to Parkinson's disease in humans A lawsuit against Dow Chemical, Corteva and FMC Corporation, the companies that developed and originally marketed chlorpyrifos, alleges they failed to adequately warn users about the pesticide's neurological risks, bringing renewed attention to the dangers faced by agricultural and pest control workers Reducing repeated pesticide exposure, supporting gut health, staying physically active, managing stress, and maintaining healthy vitamin D levels are practical steps that may help support long-term brain health, though evidence connecting them specifically to Parkinson's disease risk is still developing

Apply to work with a Muscle Intelligence Coach → https://muscleintelligence.com/apply W. Bryan Hubbard is the CEO of Americans for Ibogaine, the organization he co-founded with former Texas Governor Rick Perry, and the reason ibogaine is now inside an FDA drug development pathway. He is also a conservative Kentucky attorney who once believed anyone holding a psychedelic belonged under the jail. What changed his mind was a single Scientific American article about psilocybin and alcohol dependency, a family history with alcohol, and a decade running two of Kentucky's largest government systems while the opioid epidemic that began in his ancestral home county killed nearly a million Americans. In this episode of the Muscle Intelligence Podcast, Ben Pakulski sits down with Hubbard to understand what psychedelic therapy actually does to the brain, how ibogaine interrupts opioid addiction in a single treatment without withdrawal, and why a medicine that has never had a recreational use is now the centerpiece of a federal and state partnership. This is a conversation about the new frontier of mental health treatment for anyone who has watched addiction, PTSD, depression, or trauma take someone they love, and for anyone in the performance world who wants to understand what these medicines are before they arrive in the U.S. medical system. Hubbard explains the difference between a drug and a medicine, why psychedelics carry a built-in anti-addictive property, how ibogaine differs from psilocybin, ayahuasca, MDMA and 5-MeO-DMT, who should never take it, and what the executive order signed in April means for how soon psilocybin therapy, MDMA therapy and ibogaine treatment reach patients. He also covers the neuroregenerative research pointing toward traumatic brain injury and Parkinson's, and why natural sources have to survive the arrival of Western medical demand. 5 Key Takeaways What happens in the 36 to 48 hours after an ibogaine treatment, and why Hubbard calls it an addiction interrupter rather than a cure. The difference between a drug and a medicine, and the built-in property of psychedelics that makes them nearly impossible to abuse. Why ibogaine has no recreational use, and what that has to do with why you've never heard of it. Which psychedelic medicines are likely a year from prescription in the U.S., and which one is still years out. Who ibogaine is not for, and why Hubbard says no one should ever order it online.   Chapters 0:00 Why a Performance Podcast Is Talking About Psychedelics 10:16 What Plant Medicine Changed About How He Sees People 19:04 The Opioid Epidemic and the Discovery of Ibogaine 29:47 From Kentucky to Texas to the Executive Order 40:02 Who Ibogaine Is Not For, and Medicine vs. Drug 46:15 Why Each Psychedelic Is Different 52:16 The Timeline: What's Coming and When 56:47 Natural vs. Synthetic and the Supply Chain Problem Connect with Bryan Hubbard Website – https://www.wbryanhubbard.com Americans for Ibogaine – https://www.americansforibogaine.org X – https://x.com/w_bryan_hubbard Instagram – https://www.instagram.com/w_bryan_hubbard/ LinkedIn – https://www.linkedin.com/in/w-bryan-hubbard

“I'm not sure if I'm allowed to tell this story… But I'm gonna do it anyway.” The best stories tend to live on the wrong side of the velvet rope, and every so often a gentleman must ignore the bouncer and let the public in. Parko, being a gentleman of considerable repute, has brought several such stories with him. Bisous! Fresh off the Surf100 $100k Finale, where the public judges may have been a touch less charitable than the man deserved, Parko joins Dane and Dooma at the StabMic desk to unpack the experience of putting a jersey back on, and what he's been doing since hanging it up for good in 2018 after almost two decades on tour. There's an obvious bit of crossover here, too. Joel spent the entirety of Dane's relatively brief CT career on tour, before Dane left the building and Joel eventually did the same. Between them, they've seen enough of the institution from the inside to have developed some opinions on how the thing is constructed. It's a good old-fashioned trip down the rabbit hole. The contents of said hole: waking Adriano De Souza from his slumber for the traditional Namotu Skulldrag onslaught, the night before a heat, only to face Dane Reynolds in that very heat; rescuing Kelly Slater; the early days of the Cooly kids; Joel's diagnosis of what the modern tour has lost; and a tantalising hint at a new film project in the works with Mick. Thanks to our partners at Red Bull, Dome Dust, TurtleBox, Visit Dominican Republic, and Devium, for making StabMic possible.

I discuss the benefit and history behind the dividend for the Sovern US; the UK and Irish flex from the President and what this really means; Chicago Public Schools are closing and other schools are as well, all over the nation; and ESPN's Barry Melrose passes from the jabs.   Book Websites: HERE and HERE. https://www.moneytreepublishing.com/shop PROMO CODE: “AEFM” for 10% OFF, or https://armreg.co.uk PROMO CODE: "americaneducationfm" for 15% off all books and products. (I receive no kickbacks).  https://www.thriftbooks.com/ Q posts book: https://drive.proton.me/urls/JJ78RV1QP8#yCO0wENuJQPH

This week: a mom goes to jail for letting her kid walk to a pond, a Wendy's manager ties an employee to the counter, and newly released 9/11 documents reveal officials knew the air was toxic all along. Plus — Trump complains a 9/11 hero is more famous than him, pitches a $5,000 check his own party hates, and blames Ukraine for diesel prices. A "Karen" accuses a dad of trafficking his own kid, a flood-dodging driver threatens a homeowner with Parkinson's, a nurse is accused of trying to exorcise a nursing home patient, and Florida's Deputy of the Year quits in disgrace. We also cover a mystery naked cyclist, jurors revealing what really happened behind closed doors in the Lindsay Clancy mistrial, and two disturbing abuse cases making headlines out of the UK and Georgia. #TrueCrime #WeirdNews #CurrentEvents #Trump #Podcast

Can therapeutic ketosis be considered for type 1 diabetes and bipolar disorder? In this Metabolic Mailbag episode, Dr. Bret Scher and producer Erica Gerard answer viewer questions about ketogenic therapy, type 1 diabetes, Parkinson's medications, omega-3s, fasting, protein intake, metabolic rate, and why some protein foods are more filling than others.They cover:The association between type 1 diabetes and serious mental illnessWhy ketogenic therapy may be possible for some people living with type 1 diabetes, but only with careful medical supervisionHow Parkinson's medications can interact with protein timingWhether cooking salmon changes the benefits of omega-3 fatsHow intermittent fasting can affect protein intake and ketone levelsWhy MCT oil in coffee may change the meaning of a “fast”What basal metabolic rate means and how ketogenic diets may affect itWhy a protein shake may feel less satisfying than meat, even with the same grams of proteinFrom medication timing to protein needs, this episode explores why metabolic therapies work best when they are personalized, measured, and guided by the realities of each person's health goals and daily life.

The NFL's billion-dollar concussion settlement was designed to compensate former players suffering from the devastating neurological consequences of a career in professional football — but a bombshell report reveals that five law firms systematically exploited that system through an organized scheme of fraudulent diagnoses. Special masters appointed by a federal court found that attorneys steered clients to unapproved doctors willing to hand out Parkinson's disease diagnoses regardless of symptoms, funneling over $95 million in fraudulent claims through the fund before an audit shut it down. Today we unpack what this scandal reveals about the psychology of institutional betrayal, the vulnerability of injured athletes, and what happens when the people trusted to protect you become the threat.

Episode 2035 Brought to you by our incredible sponsor: Ultra Pouches - Don't sleep on Ultrapouches. New customers get 15% Off with code HARDFACTOR at takeultra.com!  00:00:00 Timestamps 00:03:30 AI football picks 00:08:35 Furries are being discriminated against at famous Maryland Renaissance Festival 00:22:40 Giant sinkhole opens at Nick Cage's Malibu house 00:30:20 Man with Parkinson's under fire for kicking motorists off his lawn as she was trying to avoid flooded streets 00:36:15 Rick Springfield tells Joe Rogan he killed a man while in Vietnam during USO tour For more head over to patreon.com/hardfactor for weekly bonus episodes and most importantly HAGFD! Learn more about your ad choices. Visit megaphone.fm/adchoices

Learn more about Parkinson's and find support: https://dpf.org Although a tremor is the most well-known symptom of Parkinson's, a tremor may not be the earliest symptom. Symptoms like loss of smell, constipation, acting out dreams, anxiety, and changes in handwriting can show up years before a diagnosis. Cognitive neurologist Dr. Jeffrey Maneval joins Chris Krueger to walk through the most common early signs, why Parkinson's is so often confused with conditions that mimic it, and the tests that can bring clarity, from sleep studies and DaTscans to skin biopsy and genetic testing. You don't have to wait for a formal diagnosis to start treating symptoms. Dr. Maneval discusses how early interventions, including physical therapy, Parkinson's boxing, voice therapy, and mental health support, can help you live well today, even before you have a diagnosis. Dr. Jeffrey Maneval is a board-certified neurologist at MaineHealth specializing in cognitive disorders, including dementia, Alzheimer's disease, and Parkinson's disease. As Director of Cognitive and Behavioral Neurology, he is dedicated to advancing patient care, education, and research to improve the lives of people living with neurological conditions. Sign up for updates on webinars, events, and resources for the Parkinson's community: https://dpf.org/newsletter-signup This episode is sponsored by CND Life Sciences, the developer and provider of the Syn-One skin biopsy test.

Neurofeedback pioneer Joy Lunt, RN opens this classic NeuroNoodle Open Mic conversation with a case that still grabs your attention: a client with dissociative identity disorder whose EEG "utterly changed" mid-session—"like as if somebody else was sitting in the chair." Later, Joy describes seeing the EEG of one personality look like that of a four-year-old child.This is NeuroNoodle before today's Brain Bar—the audience-driven Open Mic format where Pete Jansons brought viewer questions directly to the panel. Joy Lunt, Jay Gunkelman, Dr. Mari Swingle, Dr. Andrew Hill, John Mekrut, Joshua Moore, Anthony Ramos and the crew move from DID and EEG patterns into depression and the salience network, neurofeedback protocols, Joy's striking experience using neurofeedback with her mother after a Parkinson's diagnosis, Parkinson's and repeated head trauma, the panel's debate over "digital Ozempic" and the brain, insomnia, exhausted kids, autism, and why hyperfocus and flow are "not even close."

The radio voice of the Nashville Predators, Pete Weber, joined the show and shared his thoughts about the passing of Brent Peterson. Weber and Peterson shared the radio booth for an extended time after Peterson's coaching career ended. Peterson succumbed to Parkinson's disease, which he had been battling since 2002.

In the second hour, Chase shared the heartbreaking news of the passing of Brent Peterson, a longtime Nashville Predators Assistant Coach. Peterson succumbed to Parkinson's disease, which he had been battling since 2002. Later in the hour, we had the opportunity to hear from Titans head coach Robert Saleh as he addressed the media, and we also revisited yesterday's interview with Philip Fulmer.

In the final hour of the show, the radio voice of the Nashville Predators, Pete Weber, joined the show and shared his thoughts about the passing of Brent Peterson. Weber and Peterson shared the radio booth for an extended time after Peterson's coaching career ended. Peterson succumbed to Parkinson's disease, which he had been battling since 2002. Listen to hear more. Later in the hour, Titans Senior Writer and Editor Jim Wyatt joined the show to share his thoughts on the Titans game that took place on Sunday. He also discussed the postponement of Chris Johnson's induction into the Ring of Honor.

In the first hour of the Chase & Big Joe Show, Chase began by reflecting on the lives lost 25 years ago today, on September 11th, 2001. Later in the hour, ESPN's Herm Edwards joined the show to share his insights on the Titans and discuss the aftermath of 9/11 when he was the Jets coach. Tune in to hear more. In the second hour, Chase shared the heartbreaking news of Brent Peterson's passing, a longtime Nashville Predators Assistant Coach who succumbed to Parkinson's disease, which he had been battling since 2002. Later in the hour, Titans head coach Robert Saleh addressed the media, and we revisited yesterday's interview with Philip Fulmer. In the final hour of the show, the radio voice of the Nashville Predators, Pete Weber, joined the show to share his thoughts on Peterson's passing. Weber and Peterson had shared the radio booth for an extended period after Peterson's coaching career ended. Peterson succumbed to Parkinson's disease, which he had been battling since 2002. Later in the hour, Titans Senior Writer and Editor Jim Wyatt joined the show to share his thoughts on the Titans game that took place on Sunday. He also discussed the postponement of Chris Johnson's induction into the Ring of Honor.

In this episode of The Dept., Omar sits down with Graham Cochrane for a conversation on how to build a business that makes more money without taking over your entire life. Graham shares the philosophy behind his book The Effortless Business and explains why business does not have to be as hard, heavy, or high-maintenance as most entrepreneurs make it. Instead, the goal is to build a business around constraints, value, leverage, and the gifts that already come naturally to you. You'll learn why constraints can create clarity, how Parkinson's Law affects your work, why charging by the hour keeps people stuck, and why consulting or coaching can be one of the most effortless business models when built around what you already know. If you've been overcomplicating your business, undercharging for your value, or ignoring the thing that comes easy to you, this episode will help you rethink what it actually means to build a high-income, low-maintenance business.

Robert Wilkinson (Flamin' Oh's) and Dave Egemo (Parkinson's Foundation) stop by to give us the lowdown on the upcoming 4th Annual Parkinson's Foundation Minnesota Fundraiser. Coming up on Friday, Sept 25th at The Hook & Ladder, the evening will feature two blistering MN Music acts, Annie and the Bang Bang AND The Flamin' Oh's! Get the details here and check it out!

On its face, it sounds horrific: a mom allows her five-year-old son to walk alone to a neighborhood pond, a half mile away. That mom is Karyann Parkinson and she’s speaking out after being convicted of contributing to the delinquency of a minor. Parkinson is also now on a state abuse registry for the next seven years. The mom of five says she had just walked to the pond six times with her son that day, in their gated community, complete with security guards. It was one of those guards who escorted the boy home, and ultimately called police. Debate is now raging online among parents, how young is too young to walk alone, and what is the role of the state when it comes to making parenting decisions? See omnystudio.com/listener for privacy information.

On its face, it sounds horrific: a mom allows her five-year-old son to walk alone to a neighborhood pond, a half mile away. That mom is Karyann Parkinson and she’s speaking out after being convicted of contributing to the delinquency of a minor. Parkinson is also now on a state abuse registry for the next seven years. The mom of five says she had just walked to the pond six times with her son that day, in their gated community, complete with security guards. It was one of those guards who escorted the boy home, and ultimately called police. Debate is now raging online among parents, how young is too young to walk alone, and what is the role of the state when it comes to making parenting decisions? See omnystudio.com/listener for privacy information.

On its face, it sounds horrific: a mom allows her five-year-old son to walk alone to a neighborhood pond, a half mile away. That mom is Karyann Parkinson and she’s speaking out after being convicted of contributing to the delinquency of a minor. Parkinson is also now on a state abuse registry for the next seven years. The mom of five says she had just walked to the pond six times with her son that day, in their gated community, complete with security guards. It was one of those guards who escorted the boy home, and ultimately called police. Debate is now raging online among parents, how young is too young to walk alone, and what is the role of the state when it comes to making parenting decisions? See omnystudio.com/listener for privacy information.

Nicotine is usually discussed as an addictive drug. But in 1959, researchers noticed something unexpected: people who smoked appeared less likely to develop Parkinson's disease. That observation survived decades of scrutiny and eventually led to animal experiments, memory studies, nicotine patches, and major clinical trials. This investigation follows that evidence from the original anomaly to the latest human research to determine what nicotine actually does to the brain—and whether its neuroprotective reputation has been earned.Time Stamps0:00 – Intro1:44 – Reverse causation theory2:32 – The Swedish snus study4:00 – Animal trials: mice vs. monkeys5:16 – Nicotine's effect on the brain7:35 – The NIC-PD trial9:04 – The MIND trial11:31 – The 2009 paper that predicted the failure12:55 – What the evidence actually shows

 With host retail coach Wendy Batten   https://wendybatten.com/podcast-intro/ Episode Overview Of course you love what you do - and that's why you started your business. But perhaps you also took this leap because you wanted more control over your schedule and more freedom to do the things you love outside of work. This episode centers around answering a question that has come up countless times in my years as a retail coach and that I have even grappled with in the past as a business owner: where should I be spending my time? As business owners, we have three major resources to manage: time, money, and capacity or energy. Time is finite, which means we have to be intentional about how we use it.  We're covering a lot of ground in this episode from setting clear boundaries between work and personal life, why you should plan your week around the life you want to live now, and a time management framework that helps me think about where my time is best spent as CEO of my business.  I hope from this episode you'll think about what you really want in your life and then reverse engineer your business time to reflect your life goals and needs. Our Key Topics Why work expands to fill the time available and how setting clear boundaries can change that (Parkinson's Law at work!) How to build a life-first business by defining personal needs and capacity before determining work hours Why the business owner's role needs to evolve as the business grows, including shifting from founder to CEO What CEO and business development time should include, from planning and financials to marketing, sales, and customer experience How to protect your time, energy, and capacity by reducing time spent on administrative and repeatable tasks Key Takeaways For Shop Owners Your personal time needs boundaries, too. Stop thinking you need to work all the time. I've learned that I have to define my own boundaries around when I work and when I'm finished, because there will always be something else I could be doing in my business. Your business gets to fit into your life. Look honestly at what your life needs right now, whether that means time off, family time, travel, creative time, or simply space to enjoy your life. Then you can determine how much work time actually fits. Your CEO time cannot be the first thing to go when you are short on time. Business development includes planning, financials, decision-making, vision, and intentional learning. I've found that this is often the first category to disappear when things get busy, even though it is where the business needs leadership most. This is so important. Not everything that feels productive is moving the business forward. I want to distinguish between meaningful marketing and sales work and simply staying busy with activities like posting on social media. Dedicated time for strategy, events, emails, launches, customer experience, merchandising, conversion, and other sales activities matters. You must protect your energy. Our businesses can only grow when we are taking care of ourselves and protecting our energy. I see this as part of leadership because the energy and enthusiasm at the top of the business affect the culture and the people who interact with it. Want to work with me to plan out your week? I'm hosting a workshop on September 29th to help you do just that! Join me for Your Week By Design.  "Our businesses can only grow if we protect the asset. And we are the asset." -Wendy Batten   INSERT IMAGE HERE Resources Mentioned and Related Podcasts Are you ready to stop duct taping your marketing pieces together? To start putting real strategy in place that actually worked for your business around your marketing? The Sales and Marketing Accelerator Program is available on demand!   Episode 263: Why CEO Time Isn't Optional in Your Retail Business   Let's hang out in a private coaching session!   Follow along and chat with me on Instagram and join my love list.  About your host, Wendy Batten In case we haven't met…I'm Wendy Batten. I've been a small business owner, coach, and mentor for over 25 years. I help thoughtful, established entrepreneurs step into their role as CEO and build businesses that are profitable, meaningful, and supportive of the lives they want to live. My work blends real-world strategy with a life-first philosophy, shaped by lived experience, not theory. I've been there! Through honest conversations and practical insight, I invite you into bigger thinking about leadership, possibility, and how to build both business and life on purpose. For more support from Wendy Hang out and connect with Wendy on IG All of Wendy's current programs and services for shop owners can be found HERE. Never miss an episode! Subscribe to the Creative Shop Talk Podcast and get the tools, inspiration, and strategies you need to thrive as an independent retailer.Click here to subscribe to iTunes!  Loved the episode? Leave a quick review on iTunes- your reviews help other retailers find my podcast, and they're also fun for me to go in and read. Just click here to review, select "Ratings and Reviews" and "Write a Review" and let me know what your favorite part of the podcast is. So grateful for you! Thank you!  

I met Ruth Jenkins a year ago and was immediately fascinated by her work in improv as a Speech and Language Pathologist (SLP). She describes using her SLP and improv skills for people with Parkinson's and other neurological disorders. She has been improvising and teaching for over 35 years. She and her husband Patrick Short were the founders of Comedy Sportz Portland where she remains an active performer and workshop instructor, In 1995 she received her Master's in degree in Speech-Language Pathologist She initially worked with children and teens with articulation issues. She later switched the focus of her practice to adults with neurological disorders. She shares numerous case studies describing how the uniqueness of her practice has changed hundreds of lives for the better. Currently Ruth works directly with patients and participants, and teaches caregivers and providers in "train the trainer" settings. Check out her training for healthcare professionals “Improv Theater Techniques & S/L and Cognitive Treatment professionals Improv Theater Techniques & S/L and Cognitive Treatment.” https://youtu.be/01gKDsJANMQ?si=Gu__MGamrMcDnH7b

The eye is the only place in the human body where brain tissue is directly visible and that makes it one of the most powerful tools in early neurological disease detection. In Part 1 of this conversation, Dr. Kerry Gelb sits down with Dr. Alaina Short, an optometric physician specializing in the connection between vision and neurodegenerative disease, to explore how subtle changes in the eye can reveal early signs of Alzheimer's and Parkinson's disease long before other symptoms appear. Dr. Short walks through the five early warning signs of Alzheimer's, explains how vision changes differ from simply needing glasses, and discusses why the collaboration between optometry and neurology is becoming increasingly important for patient care. A foundational episode for anyone interested in brain health and preventive medicine.

Check out the episode in its original version here : https://www.gdiy.fr/podcast/mati-staniszewski-vo/ElevenLabs est un iceberg.On pense que c'est une startup qui permet de générer des voix avec l'IA mais il ne s'agit en réalité que de la partie visible.Des agents vocaux qui recréent la voix de patients atteints d'un cancer de la gorge pour qu'ils puissent dire leurs vœux de mariage, savent identifier des signes de Parkinson dans votre voix des années avant le diagnostic, et surtout ...un système d'engrenages d'une complexité abyssale, invisible pour l'utilisateur.La thèse de Mati, son fondateur est simple : l'écriture n'est pas le langage naturel de l'humain.Le clavier, les écrans, les interfaces qu'on utilise depuis 30 ans, sont des anomalies historiques sur le point de disparaître.Quatre ans seulement après sa création, ElevenLabs est déjà valorisé à plus de 11 milliards de dollars et réalise 600 millions d'ARR avec une équipe de 600 personnes.Une boîte européenne, qui veut rester européenne, dans un secteur dominé par les Américains.Dans cet épisode, on ouvre tous les tiroirs :Pourquoi la voix va devenir l'interface principale entre l'humain et la machineCe que ElevenLabs fait vraiment : agents, santé, éducation, IP, souveraineté des donnéesPourquoi Mati a mis un ingénieur dans chaque équipe non-techniqueLa place de l'humain dans un monde où 80% du code est déjà écrit par des machinesMême si votre curiosité n'a pas été piquée, vous DEVEZ écouter cet épisode.C'est impératif pour comprendre où l'on va et surtout comment agir dès maintenant avant qu'il ne soit trop tard…Vous pouvez contacter Mati sur Linkedin, X, Instagram.TIMELINE:00:00:00 : Les premières lignes de code de Mati et les débuts d'ElevenLabs00:10:57 : Ses précédentes expériences chez BlackRock et Palantir00:18:45 : Quitter la Pologne à 18 ans et découvrir ses ambitions00:26:35 : Comment fonctionnent les IA qui parlent00:35:42 : Rendre la voix aux personnes qui l'ont perdue00:40:01 : Briser la barrière des langues00:48:28 : L'homme n'est pas fait pour écrire mais pour parler00:54:03 : La fin des écrans ?00:59:35 : Agents fusionnés ou cascadés : le vrai compromis01:15:30 : Ce que BlackRock et Palantir lui ont appris - et ce qui change en 202601:24:37 : La plateforme, les clients enterprise et le modèle économique01:32:15 : La place de l'humain dans un monde d'agents IA01:39:31 : Comment mettre l'IA au service de l'éducation01:47:43 : Darth Vader, Epic Games et les crises de croissance01:53:29 : Passer le test de Turing et rester européenLes anciens épisodes de GDIY mentionnés : #553 - Paul Frambot - Morpho - Briser le cartel bancaire avec 600 lignes de code#543 - Yann Le Cun - AMI Labs - Rendre l'IA plus humaine#507 - Laurent Alexandre - Auteur - Vers la fin des études supérieures ?#397 - Yann Le Cun - Chief AI Scientist chez Meta - L'Intelligence Artificielle Générale ne viendra pas de Chat GPT#354 - Alex Bouaziz - Deel - Fonder discrètement une décacorne valorisée à 12 milliards de dollars, pour devenir le plus gros DRH du monde#343 - Jonathan Cherki - Contentsquare - Tout faire à 400% et fonder la référence de la French Tech valorisée à plus de $5MDS#327 - Laurent Alexandre - Auteur - ChatGPT & IA : "Dans 6 mois, il sera trop tard pour s'y intéresser"#165 - Laurent Alexandre - Doctissimo - La nécessité d'affirmer ses idéesNous avons parlé de :ElevenLabsCopernicus High SchoolBlackrockPalantirWhisprFlowDark Vador dans FortniteLa femme qui avait perdu sa voix avant son mariageLe test de TuringLe blog d'ElevenLabsLes recommandations de lecture :Dune, de Frank Herbert

Retrouvez l'épisode en version française ici : https://www.gdiy.fr/podcast/mati-staniszewski-vf/ElevenLabs is an iceberg.People think it's a startup that uses AI to generate voices, but that's actually just the tip of the iceberg.Voice agents that can recreate the voices of throat cancer patients so they can say their wedding vows, identify signs of Parkinson's in your voice years before a diagnosis, and above all...a staggeringly complex system of gears, invisible to the user.The thesis of Mati, its founder, is simple: writing is not the natural language of humans.Keyboards, screens, and the interfaces we've been using for 30 years are historical anomalies on the verge of disappearing.Just four years after its founding, ElevenLabs is already valued at over $11 billion, with $600 million in ARR and a team of more than 600 people.A European company that wants to remain European in a sector dominated by Americans.In this episode, we pull out all the stops:Why voice will become the primary interface between humans and machinesWhat ElevenLabs really does: agents, healthcare, education, IP, data sovereigntyWhy Mati has placed an engineer on every non-technical teamThe role of humans in a world where 80% of code is already written by machinesAnd even if this hasn't piqued your curiosity, you MUST listen to it.It's essential for understanding where we're headed and, above all, how to take action right now before it's too late…You can contact Mati on LinkedIn, X, and Instagram.TIMELINE:00:00:00 : Mati's first lines of code and the early days of ElevenLabs00:10:57 : His previous experiences at BlackRock and Palantir00:18:45 : Leaving Poland at age 18 and discovering his ambitions00:26:35 : How AI that speaks works00:35:42 : Giving a voice back to people who have lost theirs00:40:01 : Breaking down language barriers00:48:28 : Humans aren't meant to write, but to speak00:54:03 : The end of screens?00:59:35 : Fused or cascaded agents: the real trade-off01:15:30 : What BlackRock and Palantir taught him—and what's changing in 202601:24:37 : The platform, enterprise clients, and the business model01:32:15 : The role of humans in a world of AI agents01:39:31 : How to put AI to work in education01:47:43 : Darth Vader, Epic Games, and growing pains01:53:29 : Passing the Turing test and staying EuropeanWe referred to previous GDIY episodes : #553 - Paul Frambot - Morpho - Briser le cartel bancaire avec 600 lignes de code#543 - Yann Le Cun - AMI Labs - Rendre l'IA plus humaine#507 - Laurent Alexandre - Auteur - Vers la fin des études supérieures ?#397 - Yann Le Cun - Chief AI Scientist chez Meta - L'Intelligence Artificielle Générale ne viendra pas de Chat GPT#354 - Alex Bouaziz - Deel - Fonder discrètement une décacorne valorisée à 12 milliards de dollars, pour devenir le plus gros DRH du monde#343 - Jonathan Cherki - Contentsquare - Tout faire à 400% et fonder la référence de la French Tech valorisée à plus de $5MDS#327 - Laurent Alexandre - Auteur - ChatGPT & IA : "Dans 6 mois, il sera trop tard pour s'y intéresser"#165 - Laurent Alexandre - Doctissimo - La nécessité d'affirmer ses idéesA few recent episodes in English : #542 - VO - Yoni Assia - eToro - “AI Will Replace Most Traders in 18 Months”#513 - VO - Jesper Brodin - IKEA - 40 billion in revenue empire with no bank loan#500 - VO - Reid Hoffman - LinkedIn, Paypal - How to master humanity's most powerful invention#487 - VO - Anton Osika - Lovable - Internet, Business, and AI: Nothing Will Ever Be the Same Again#475 - VO - Shane Parrish - Farnam Street - Clear Thinking: The Decision-Making Expert#473 - VO - Brian Chesky - Airbnb - « We're just getting started »#452 - VO - Reid Hoffman - LinkedIn, Paypal - L'humanité 2.0 : Homo technicus plus qu'Homo sapiens#437 - James Dyson - Dyson - “Failure is more exciting than success”#431 - Sean Rad - Tinder - How the swipe fever took over the worldWe spoke about :ElevenLabsCopernicus High SchoolBlackrockPalantirWhisprFlowDarth Vader in FortniteThe woman who lost her voice before her weddingThe Turing testThe ElevenLabs blogReading Recommendations :Dune, de Frank Herbert

Stephen Jenkinson, culture activist, author, and teacher of grief and death literacy, reveals how facing a neurodegenerative diagnosis serves as a profound lens into the nature of mind, mortality, and human presence. Moving beyond clinical definitions of Parkinson's disease, he explains how the erosion of dopamine—what he terms the "give a shit elixir"—alters the connection between emotional affect and internal experience, forcing a drastic reconsideration of personal habits and identity.From reflecting on the "awful clarity" of a mind in eclipse to writing his journal entries in *Trembling Still*, Stephen explores the disfiguring psychic distress that accompanies neurological decline. He cautions against viewing life as a pursuit to keep being oneself no matter what, while demonstrating how the physical act of splitting wood and performing musical recitations becomes an active refusal to prematurely surrender to physical limitation.Tracing his journey from writing *Die Wise* to navigating his current physical reality, Stephen contrasts mainstream medical reliance on future-oriented hope with a disciplined, present-moment engagement. He examines the confounding alchemy of "grief love" and the concept of "harrowing," illustrating how breaking through hardened, inert surfaces keeps human sorrow liquid and makes room for genuine joy.Is human identity bound strictly to neurological acuity and functional survival, or does the devastation of hard times offer a rare, grace-filled discipline to engage the present moment with profound love and clarity?___

Broadcast from KSQD, Santa Cruz on 9-03-2026: With CDC vaccine guidance politically contested, major medical societies (AAFP, AAP, ACOG, IDSA) issued their own recommendations through the Vaccine Integrity Project. Dr. Dawn recommends flu shots in October for peak Thanksgiving antibodies, high-dose flu vaccine (not adjuvanted) for frail seniors, and COVID/flu/RSV given at the same visit—except delay COVID vaccination four to six months after recent infection. Pregnant women should receive RSV vaccine at 32-36 weeks, and infants under eight months entering their first RSV season need vaccination if the mother wasn't vaccinated. RSV is one-time only for adults 75+, or for high-risk 50-74-year-olds. Measles is the most contagious human disease, transmissible through brief incidental contact (buses, taxis, carnival rides). Beyond acute mortality (one in 5,000 pre-vaccine), survivors face rare but catastrophic subacute sclerosing panencephalitis 10-40 years later—immune-mediated brain destruction comparable to Huntington's. Thirty percent of current outbreak cases are in adults reflecting decades of under-vaccination in certain communities, and pregnant unvaccinated mothers create a dangerous one-year window since the live vaccine cannot be given during pregnancy. Inlicitide (brand name Lipithandra) is the first oral PCSK9 inhibitor for LDL reduction, priced at $315/month versus $600 for the injectable version. Dr. Dawn positions it strictly as a treatment—not preventive—drug for patients who've had a heart attack or equivalent event and cannot achieve target LDL on statins alone, with prior authorization typically successful given documented disease. Updated cancer screening guidance from major societies: cervical cancer screening at 25 for HPV-vaccinated women (earlier if unvaccinated), annual mammograms from 45-54 then biennial, PSA screening starting at 50, and low-dose CT lung cancer screening at 50-80 for heavy smokers. Dr. Dawn pushes back on the 2018 Task Force downplaying of PSA screening, noting MRI-targeted transperineal biopsies have dramatically reduced false-positive complications. She also warns about rising male cancer diagnoses at later stages for stomach, lung, tongue, and throat cancers, and recommends the vinegar test for suspicious oral white spots. Parkinson's disease develops through a decades-long prodromal phase before motor symptoms appear—by tremor onset, at least half the substantia nigra neurons are dead. Four early warning signs: persistent loss of smell (90% of Parkinson's patients experience this up to 20 years before diagnosis; free scratch-and-sniff cards available from The Michael J. Fox Foundation), REM sleep behavior disorder (acting out dreams; 50-70% develop Parkinson's or Lewy body dementia within 5-10 years, 130-fold higher risk if over 50), chronic constipation (possibly linked to gut microbiome production of misfolded alpha-synuclein), and orthostatic hypotension. Available diagnostics include alpha-synuclein seed amplifier assay (CSF), skin biopsy, and DaTscan SPECT imaging (typically covered with "clinical uncertainty" documentation). A caller with insomnia asks about using vinegar to clean his new CPAP machine. Dr. Dawn recommends one part white vinegar to three parts warm water, then rinsing—or unscented Dr. Bronner's castile soap. She emphasizes avoiding bleach, alcohol, ammonia, scented soaps, and moisturizers, since mold prevention is the primary cleaning goal. Columbia University's STAR (Sperm Track and Recovery) AI system, inspired by astronomical star-detection algorithms, hunts vanishingly rare sperm in men with azoospermia by streaming semen through a hair-thin channel imaged 300 times per second. A robotic arm extracts flagged cells within milliseconds. Of 175 patients tested, 30% had recoverable sperm, and the system produced its first baby late last year for a couple with 20 years of infertility.

A comprehensive guide to ibogaine's healing power, cultural roots, and clinical potential“A compelling call for further research into the potential of ibogaine therapy.”—Kirkus Reviews• Explores how ibogaine works, including how it boosts cellular function,increases neuroplasticity, and interrupts habitual behavior patterns and trauma• Discusses the ritual roots of iboga in the Bwiti spiritual tradition of Gabon• Shares case studies showing ibogaine's healing effects for addiction recovery, traumatic brain injury (TBI), and Parkinson'sIbogaine is an alkaloid derived from the iboga plant, native to Central Africa. Its healing effects are revered within the Bwiti spiritual tradition of Gabon. International ibogaine expert Jonathan Dickinson explores how this psychedelic substance is now emerging as one of the most promising tools in neuro-regenerative medicine, addiction recovery, and treating trauma.Grounded in fieldwork and more than 15 years of clinical observation, Dickinson shows how ibogaine interacts with the body and mind, inducing a “bicameral state” of consciousness. This is a liminal mode of being in which ancient voices, archetypes, and internal guidance systems emerge, often catalyzing a profound reorganization of memory, identity, and behavior.He details how ibogaine boosts cellular function and shares impressive case studies to demonstrate how ibogaine has successfully treated PTSD, traumatic brain injury, Parkinson's, neuropathic pain, and multiple sclerosis.As a clinician scientist, Dickinson has helped a multitude of veterans with their post-traumatic mental health struggles. As a Bwiti initiate, he is able to present in this book a unique understanding and new framework for engaging with this transformational psychedelic medicine.Jonathan Dickinson is the CEO and cofounder of Ambio Life Sciences, the world leader in integrative ibogaine treatments, and is also the founder of Terragnosis. He has more than 15 years of experience in clinical care, traditional practice, and psychedelic research. He was initiated into a Dissoumba/Fang branch of Bwiti in 2014 and the Missoko tradition in 2022. He lives in Toronto, Canada.https://ambio.life/Become a supporter of this podcast: https://www.spreaker.com/podcast/earth-ancients--2790919/support.

What does Parkinson's smell like? Ask nurse Joy Milne. Born with a hypersensitive nose, she spent a lifetime learning to recognize diseases through their scents. When she smelled Parkinson's on her husband years before his diagnosis, she decided to put her gift to the test. Today, her extraordinary nose has been translated into a non-invasive test — helping researchers diagnose what was right under their noses all along. Hosted on Acast. See acast.com/privacy for more information.

This series is sponsored by Mira and Daniel Stokar.Join Talmud Daily! A new free program from 18Forty. Ten-minute episodes a day (video + audio). Plain English. No prior knowledge assumed. No Hebrew required. Join here: Talmuddaily.orgIn this episode of the 18Forty Podcast, we talk to Tania Friedlander, leadership-and-performance coach, attorney by training, and former champion athlete, about how her husband's Parkinson's diagnosis challenged her expectations and taught her to become capable of more.In this episode we discuss:—What does it mean to make our expectations a central focus of our teshuva?—How do we increase our capacity to handle the life we have?—How can we embrace both the joy and pain that accompany the challenges of life?Interview begins at 11:42.Tune in to hear a conversation about taking on challenges head-on and finding the capacity to meet life as it comes.Tania Friedlander is a leadership and performance coach, attorney by training, and former champion athlete. A Professional Certified Coach and Gallup Certified Global Strengths Coach, she works with executives and emerging leaders to leverage their strengths, overcome challenges, and achieve their professional and personal goals.References:TanyaRabbanit Rachelle Fraenkel on the 18Forty PodcastI'm Not Alone by Riva PomerantzLoving Someone Who Has Dementia by Pauline BossMan's Search for Meaning by Viktor E. FranklChop Wood Carry Water by Joshua MedcalfLikutei Moharan, Part II 23:1For more 18Forty:NEWSLETTER: 18forty.org/joinSign up for Talmud DailyCALL: (212) 582-1840EMAIL: info@18forty.orgWEBSITE: 18forty.orgIG: @18fortyX: @18_fortyWhatsApp: join hereBecome a supporter of this podcast: https://www.spreaker.com/podcast/18forty-podcast--4344730/support.

Dr. Masud Husain is a Professor of Neurology & Cognitive Neuroscience at the University of Oxford and a leading expert on the science of motivation, apathy, and neurological diseases. We discuss how dopamine and specific brain circuits shape motivation, including how the brain weighs the trade-off between effort vs reward when deciding what goals to pursue. Dr. Husain also explains practical tools to increase motivation, reduce distractions, and make it easier to start and maintain goal pursuit. We also discuss dementia, Parkinson's and Alzheimer's disease, including new insights into cognitive resilience and factors that help protect against age-related cognitive decline. Show notes: https://go.hubermanlab.com/masud-husain-295 Thank you to our sponsors AG1: https://drinkag1.com/huberman David: https://davidprotein.com/huberman BetterHelp: https://betterhelp.com/huberman Eight Sleep: https://eightsleep.com/huberman Function: https://functionhealth.com/huberman Timestamps (00:00:00) Masud Husain (00:02:24) Apathy, Motivation (00:08:07) Rewards, Apathy & Motivation; Dopamine (00:13:20) Sponsors: David & BetterHelp (00:15:44) Types of Apathy; Goal Prioritization: Effort vs Rewards (00:23:26) Motivation, Apathy, Tool: Activation Energy & Overthinking (00:29:24) Tools to Increase Motivation: Incentives, Subdivide Tasks, Planning (00:35:13) Subjective Effort, Mental Framing; Learning & Motivation (00:42:24) Sponsors: AG1 & Eight Sleep (00:44:54) Perseverance, Failure; Finding Your Passion, Depression vs Apathy (00:50:58) Self-Concept, Ambition; Life Satisfaction (00:58:25) Psychedelics, Anhedonia & Changing Self (01:03:09) Personal & Social Identity, Tools: Curiosity, Purpose & Dementia Risk (01:11:58) Addiction, Dopamine; Social Media & Dopamine "Hits"? (01:18:36) Sponsor: Function (01:20:13) Dopamine, Parkinson's Disease; Other Roles of Dopamine (01:26:59) Life Purpose, Culture; Reflection, Weighing Decisions (01:34:21) Internal & External Attention (01:39:59) Internal Chatter, Distraction; Working Memory, Stimulants, Nicotine (01:48:54) ADHD, Diagnosis; Attention & Motivation (01:54:34) Goal Planning & Perseverance (01:59:44) Alzheimer's Disease, Dementia, Apathy, Tools: Dementia Risk Factors (02:06:55) Neurodegenerative Disease & Emerging Treatments (02:10:59) Can You Train Attention?, Tool: Reduce Distraction (02:15:14) Enrichment, Art (02:17:45) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices