Podcasts about Oxt

BUFFALO, NY — June 17, 2025 — A new #research paper was #published in Aging (Aging-US) Volume 17, Issue 5, on May 1, 2025, titled “Oxytocin modulates insulin and GLP-1 secretion in pancreatic islets.” In this study, scientists from Fukushima Medical University School of Medicine investigated how the hormone oxytocin (Oxt) influences insulin levels by acting on specific cells in the pancreas. The team led by first author Kasumi Hattori and corresponding authors Kenju Shimomura and Yuko Maejima discovered that oxytocin may indirectly increase insulin secretion by triggering another hormone, GLP-1, from within the pancreas. This finding could lead to new strategies for improving blood sugar control in people with diabetes. Oxytocin is commonly known for its roles in childbirth and social bonding, but scientists have also been exploring its effects on metabolism. While previous studies offered mixed results about whether oxytocin raises or lowers blood sugar, this research brings new clarity. The study focused on oxytocin's impact on insulin and a hormone called GLP-1, which helps regulate insulin production. Researchers tested this by using mice with and without oxytocin receptors and found that oxytocin's ability to raise insulin levels depended on the presence of these receptors and high blood sugar conditions. Researchers found that oxytocin stimulates the release of “intra-islet GLP-1,” a form of GLP-1 produced inside the pancreas rather than the intestine. In the pancreas, insulin is produced by beta cells, while alpha cells produce glucagon, a hormone that raises blood sugar. But recent research, including this study, has shown that alpha cells can also release GLP-1, which in turn helps beta cells secrete insulin. Oxytocin appears to increase this internal GLP-1 release, especially when blood sugar levels are high, thereby leading to insulin release in a natural and targeted way. In this study researchers were also able to detect the difference between oxytocin's effect on blood sugar and its effect on insulin. They observed that right after oxytocin was given, blood sugar levels rose in all mice—even in those that lacked oxytocin receptors. However, only the mice with working oxytocin receptors showed a later increase in insulin. This suggests that oxytocin may trigger insulin production through a separate, receptor-dependent pathway involving the hormone GLP-1. "WT mice showed a significant increase in insulin levels at 15-min, while OxtR KO mice did not." This indirect action—oxytocin triggering alpha cells to release GLP-1, which then acts on beta cells—may represent a novel mechanism for controlling insulin release. It also explains why oxytocin does not increase insulin in low-glucose conditions, making it a potentially safer option for regulating blood sugar. As treatments for type 2 diabetes increasingly focus on GLP-1–based drugs, this study opens the door to using oxytocin or similar compounds to naturally enhance the body's own insulin-producing system. With further research, this mechanism could help develop new therapies that better mimic the body's natural glucose control, particularly beneficial for older adults with diabetes. DOI - https://doi.org/10.18632/aging.206244 Corresponding authors - Kenju Shimomura - shimomur@fmu.ac.jp, and Yuko Maejima - maejimay@fmu.ac.jp Video short - https://www.youtube.com/watch?v=C0K6uDX4z8U To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Date: December 14, 2023 032. No Holds Barred w/ Special Guests: Diverter, Author - Mining for the Streets & Samourai Wallet, Co-Founder - Samourai Wallet State of the Network:  Block Height: 821220 According to our friends at newhedge.io: Bitcoin difficulty is 67.3T after the recent downward adjustment of -0.95% on Saturday, December 9, 2023 Looking at mempool.space: Hashrate appears to be 484Eh on the 14-day MA Heading over to insights.braiins.com: Hash value is currently 255 sats/TH/day Days until the Halving: 126 days according to https://www.coinwarz.com/mining/bitcoin/halving Stream Sats, Point Hash: Pick any Lincoin URL:      a) stratum+tcp://NA.lincoin.com:3333      b) stratum+tcp://EU.lincoin.com:3333      c) stratum+tcp://LatAm.lincoin.com:3333      d) stratum+tcp://CIS.lincoin.com:3333      e) stratum+tcp://Asia.lincoin.com:3333      f) stratum+tcp://OC.lincoin.com:3333      g) stratum+tcp://Africa.lincoin.com:3333 Then use "pod256.YourAlias" as the worker name. Shout out to: Blizabler for supporting the podcast with their hashrate over the last few weeks No Holds Barred w/ Special Guests: Diverter, Author - Mining for the Streets & Samourai Wallet, Co-Founder - Samourai Wallet For the record, an invitation to join POD256 was also extended to Luke Dashjr from Ocean Mining, however that invitation was ignored. Audience questions: https://x.com/econoalchemist/status/1734976803788161367 Samourai Wallet: https://samouraiwallet.com/ Bitcoin blockchain explorer and fee estimator: https://light.oxt.me/ Understanding Bitcoin Privacy with OXT: https://medium.com/oxt-research/understanding-bitcoin-privacy-with-oxt-part-1-4-8177a40a5923 Mining for the Streets: A simple guide for acquiring bitcoin without KYC/AML using ASIC mining: https://diverter.hostyourown.tools/mining-for-the-streets/ Diverter on Twitter: https://twitter.com/Diverter_NoKYC Samourai Wallet on Twitter: https://twitter.com/SamouraiWallet Rod @bitkite on Twitter: https://twitter.com/bitkite Econoalchemist on Twitter: https://twitter.com/econoalchemist Rod @bitkite on nostr: npub1atn7mlwt08erz4ap47gef92xfey65a4z9ed9vec53u5kc9v94pusl6h4x3 Econoalchemist on nostr: npub10m6lrv2kaf08a8um0plhj5dj6yqlw7qxzeag6393z352zrs0e5nsr2tff3 Bitcoin Park on Twitter: https://twitter.com/bitcoinpark_ POD256 on Twitter: https://twitter.com/pod256

Welcome to Episode 16 of the Nerdcast Empire!This is the second of a two-part episode talking about the year in anime 2022. Matt, Mike and Chris talk about their favorite anime music from 2022. Which songs were their favorite anime opening and ending themes from the year?Don't forget to check out part one of the Year in Anime 2022, already available, where the guys talk about their top anime shows of 2022.This week it's all about our top anisongs of 2022. Tune in!

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.19.549666v1?rss=1 Authors: Berkhout, J., Poormoghadam, D., Yi, C.-X., Kalsbeek, A., Meijer, O., Mahfouz, A. Abstract: The hypothalamic paraventricular nucleus (PVN) is a highly complex brain region that is crucial for homeostatic regulation through neuroendocrine signalling, outflow of the autonomic nervous system, and projections to other brain areas. The past years, single-cell datasets of the hypothalamus have contributed immensely to the current understanding of the diverse hypothalamic cellular composition. While the PVN has been adequately classified functionally, its molecular classification is currently still insufficient. To address this, we created a detailed atlas of PVN transcriptional cell types by integrating various PVN single-cell datasets into a recently published hypothalamus single-cell transcriptome atlas. Furthermore, we functionally profiled transcriptional cell types, based on relevant literature, existing retrograde tracing data and existing single-cell data of a PVN-projection target region. In our PVN atlas dataset, we identify the well-known different neuropeptide types, each composed of multiple novel subtypes. We identify Avp-Tac1, Avp-Th, Oxt-Foxp1, Crh-Nr3c1 and Trh-Nfib as the most important neuroendocrine subtypes based on markers described in literature. To characterize the pre-autonomic functional population, we integrated a single-cell retrograde tracing study of spinally-projecting pre-autonomic neurons into our PVN atlas. We identify these (pre-sympathetic) neurons to co-cluster with the Adarb2+ clusters in our dataset. Finally, we identify expression of receptors for Crh, Oxt, Penk, Sst, and Trh in the dorsal motor nucleus of the vagus, a key region that pre-parasympathetic PVN neurons project to. Concluding, our study present a detailed overview of the transcriptional cell types of the murine PVN, and provides a first attempt to resolve functionality for the identified populations. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Gabriel Custodiet speaks with Samourai Wallet, the main speaker for the eponymous Bitcoin privacy wallet company. This wide-ranging discussion covers the myth of Bitcoin being a "surveillance coin," chain analytics companies, the history of Samourai and Bitcoin privacy wallets, and the trailblazing techniques of how SW runs an online, globally-dispersed business that does not compromise on its values. For more introductory information on Samourai Wallet, please start with this video: https://youtu.be/icyeO70ICi4 and then continue to this one: https://youtu.be/HNeYNTadDiE. You can also make use of the Samourai privacy tools by using the Sparrow Wallet, which we have discussed regularly on this show. That will be the preferred method for many. Guest Links → https://samouraiwallet.com/ → https://twitter.com/samouraiwallet → https://twitter.com/SamouraiDev (Samourai Wallet's partner) → https://twitter.com/LaurentMT (Creator of OXT.me) → https://t.me/SamouraiWallet (Telegram group) → https://oxt.me/ (Blockchain explorer) → https://www.youtube.com/watch?v=QEnL5k0R08w&list=PLIBmWVGQhizLrPjpFMN5bQdbOZRxCQXUg (Bitcoin Privacy Series) Resources Mentioned → Roman Sterlingov case: https://www.podpage.com/citadeldispatch/cd100-the-disturbing-chainalysis-led-prosecution-of-roman-sterlingov-with-mike-hassard-and-tor-ekeland/  Watchman Privacy → https://watchmanprivacy.com (newsletter, consultation requests) → https://twitter.com/watchmanprivacy → https://www.amazon.com/Watchman-Guide-Privacy-Financial-Lifestyle/dp/B08PX7KFS2   Privacy Courses (supports the show) → https://rpf.gumroad.com/l/privatebitcoin → https://rpf.gumroad.com/l/hackproof   Monero Donation Address (If you can't see the whole string, double click in the middle to select all) →8829DiYwJ344peEM7SzUspMtgUWKAjGJRHmu4Q6R8kEWMpafiXPPNBkeRBhNPK6sw27urqqMYTWWXZrsX6BLRrj7HiooPAy   Please subscribe to and rate this podcast wherever you can to help it thrive. Thank you! → https://www.youtube.com/@WatchmanPrivacy  →https://odysee.com/@WatchmanPrivacy   Timeline **BITCOIN PRIVACY** 0:00 – Introduction 1:48 – Bitcoin is not a “surveillance coin” – two scenarios 10:50 – Roman Sterlingov case and chain analytics 13:20 – Chain analytic and surveillance companies 19:52 – Bitcoiners punished for FUTURE transactions? 22:44 – What would you say to mainstream Bitcoiners? 25:47 – How to learn about blockchain analytics; OXT.me **SAMOURAI WALLET** 29:30 – History of Bitcoin privacy wallets 32:32 – Where did idea of Whirlpool come from? 36:34 – Why is SW Android only? 38:32 – How would Samourai Wallet start up his own wallet? 41:43 – Why aren't some privacy features on by default? 48:13 – Samourai's connection with Sparrow Wallet 51:03 – Can we trust the Centralized Coordinator of Whirlpool? 55:58 – Update on Decentralized Coordinator 57:24 – Which features of Samourai Wallet would you use? 1:04:01 – What would you do if you controlled Satoshi's wallet? **POLITICS AND PHILOSOPHY** 1:10:30 – Privacy is not a human right; it's a human fight 1:13:40 – Justification of “not being polite” on Twitter 1:18:36 – Pushback from mainstream Bitcoiners 1:27:57 – Samourai Wallet core values **RUNNING AN ANTIFRAGILE BUSINESS** 1:29:58 – Privacy methods for running a business 1:33:24 – Self-hosting everything 1:35:30 – Where did he learn all of this? 1:37:18 – Evacuating the UK over AML nonsense 1:41:26 – How to live on Bitcoin-only 1:45:40 – Atomic swaps with Monero 1:47:39 – Final thoughts   #WatchmanPrivacy #SamouraiWallet #BitcoinPrivacy

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.28.517564v1?rss=1 Authors: Carson, K. E., Alvarez, J., Mackley, J., Travagli, A., Browning, K. N. Abstract: Perinatal high fat diet (pHFD) exposure is known to affect the development of vagal neurocircuits that control gastrointestinal (GI) motility and reduce stress resiliency in offspring. Descending oxytocin (OXT; prototypical, anti-stress peptide) and corticotropin releasing factor (CRF; prototypical, stress peptide) inputs from the paraventricular nucleus (PVN) of the hypothalamus to the dorsal motor nucleus of the vagus (DMV) modulate the GI stress response. However, how these descending inputs, and their associated changes to GI motility and stress responses, are altered following pHFD exposure are unknown. The present study used in vivo recordings of gastric tone and motility, in vivo assays of gastric emptying rates, in vitro electrophysiological recordings from brainstem slice preparations, and retrograde neuronal tracing experiments to investigate the hypothesis that pHFD alters descending PVN-DMV inputs, dysregulating DMV neuronal responses and subsequent gastric motility. Basal gastric emptying rates were found to be significantly delayed in pHFD rats, which also demonstrating an inability to mount an appropriate response to acute stress with a further delay in gastric emptying. Neuronal tracing experiments suggested that pHFD reduced PVNOXT neurons that project to the DMV but increased PVNCRF projections. Whole cell patch clamp recordings of DMV neurons demonstrated that, following pHFD, PVNCRF projections are tonically active, altering GABAergic inputs to DMV neurons. Lastly, blocking DMV CRF receptors in pHFD rats restored the appropriate gastric response to brainstem oxytocin application. Taken together, these results indicate that pHFD exposure leads to an upregulating of CRF inputs to the DMV, resulting in tonic CRF activation on the system and altering gastric motility. These results suggest that pHFD exposure leads gastric dysmotility, leading to a maladaptive gastric stress response and reduced stress resiliency. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

The hosts of the Otkau Spirit Animecast listen to some great tunes provided by the Fall 2022 Anime Season. Listen in and enjoy! Listen to all the Otaku Spirit Music Picks on Spotify! https://open.spotify.com/playlist/5aQWhNSReEJN27iO8xTIEQ?si=788e4f1aa58e42a4 Reincarnated as a Sword OP "Tensei Shitara Ken deshita" by Kishida Kyoudan and The Akeboshi Rockets More Than A Married Couple, But Not Lovers ED “Stuck on you” by Nowlu Bocchi The Rock OP “Seishun Complex” by Kessoku Band Blue Lock OP1 "Chaos ga Kiwamaru" by UNISON SQUARE GARDEN Peter Grill Super Extra ED "Koi Gokoro" by Hilcrhyme Akiba Maid War OP "Maid Daikaiten" by the Ton Tokoton staff Urusei Yatsura OP1 "Aiue" by MAISONdes, Minami, SAKURAmoti Minami: Domestic Girlfriend Urusei Yatsura ED1 "Tokyo Shandy Rendezvous" by KAF, Tsumiki My Hero Academia 6 OP "Hitamuki" by SUPER BEAVER My Hero Academia 6 ED "SKETCH" by Kiiro Akiyama Spy X Family Part 2 OP "SOUVENIR" by BUMP OF CHICKEN Spy X Family Part 2 ED "Shikisai" by yama Legend of Mana The Teardrop Crystal OP "Tear of Will" by Saori Hayami Raven in the Inner Palace ED "Natsu no Yuki" by krage Golden Kamuy 4 OP "NEVER SAY GOODBYE feat. Mummy-D" by ALI Golden Kamuy 4 ED "Subete ga Soko ni Arimasu You ni." by THE SPELLBOUND The Eminence In Shadow OP "HIGHEST" by OxT Chainsaw Man OP "KICK BACK" by Kenshi Yonezu Chainsaw Man ED "CHAINSAW BLOOD" by Vaundy My Master Has No Tail OP "Genai Yuugi" by GARNiDELiA Beast Tamer OP "Change The World" by MADKID The Human Crazy University OP "CATASTROPHE" by nano Mob Psycho 100 III OP "1" by MOB CHOIR Bibliophile Princess OP "Prologue" by Yuka Iguchi Gundam The Witch From Mercury OP 1 "Shukufuku" by YOASOBI Gundam The Witch From Mercury ED 1 "Kimi yo Kedakaku Are" by Shiyui Do It Yourself OP "Dokidoki Idea wo Yoroshiku!" by Katajou DIY-bu!! Uzaki-chan Wants to Hang Out 2 OP "Ichigo Ichie Celebration” by Kano and Uzaki-chan (CV: Naomi Oozora) Bleach TYBW OP "Scar" by Tatsuya Kitani Bleach TYBW ED "Saihate" by SennaRin Encouragement of Climb Next Summit OP "Omoi nochi Hare" by Aoi (Yuka Iguchi), Hinata (Kana Asumi) Welcome to Demon School Iruma-kun 3 ED1 "Nabebugyou" by WEDNESDAY CAMPANELLA Tips: https://streamelements.com/otakuspirit/tip Patreon: https://www.patreon.com/OtakuSpirit Merch: https://otaku-spirit.creator-spring.com/ YouTube: https://youtube.com/otakuspirit Discord: https://discord.com/invite/BZ8ZN58u6M Website: https://OtakuSpirit.com

Audio from the July 27th, 2022 installment of “Polygon Alpha” with Travis Cannell - Head of Product at Orchid Protocol.LinkTree - https://linktr.ee/polygonalphapodcastPolygon Alpha Shorts - https://tinyurl.com/PolygonAlphaShortsYouTube - https://www.youtube.com/c/PolygonTVApple - Follow the show on Apple Podcast!Spotify - Follow the show on Spotify!RSS feed - https://api.substack.com/feed/podcast/863588.rssThe Orchid Network - Enables a decentralized virtual private network (VPN), allowing users to buy bandwidth from a decentralized pool of service providers. - Orchid uses an ERC-20 utility token called OXT, a new VPN protocol for token-incentivized bandwidth proxying, and smart-contracts with algorithmic advertising and payment functions. - Orchid's users connect to bandwidth sellers using a provider directory, and they pay using probabilistic nanopayments so Ethereum transaction fees on packets are acceptably low. - Orchid Accounts: Orchid accounts are the decentralized entities that store digital currency on a blockchain to pay for services through nanopayments. The nanopayment smart contract governs Orchid accounts. The Orchid client requires an account in order to pay for VPN service. - The Orchid Client: An open-source, Virtual Private Network (VPN) client that supports decentralized Orchid accounts, as well as WireGuard and OpenVPN connections. The client can string together multiple VPN tunnels in an onion route and can provide local traffic analysis. - The Orchid DApp: The Orchid dApp allows you to create and manage Orchid Accounts. The operations supported by the account manager are simply an interface to the decentralized smart contract that holds the funds and governs how they are added and removed.~~~~Thank you so much for listening & watching the video, if you've not subscribed to the channel please do! We'll continue to bring new videos to you!Polygon offers scalable, affordable, secure and carbon-neutral web3 infrastructure built on Ethereum. Our products offer developers to create user-friendly applications #onPolygon with low transaction fees and without ever sacrificing securityPolygon official channel:Website: polygon.technologyTwitter: twitter.com/0xPolygonTelegram Community: t.me/polygonofficialTelegram announcement: t.me/PolygonAnnouncementsReddit: www.reddit.com/r/0xPolygon/Discord: discord.com/invite/polygonFacebook: www.facebook.com/0xPolygon.Technology/Polygon Alpha Podcast This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit polygonalpha.substack.com

The Hosts of the Otaku Spirit Animecast dive into the best music of Summer 2022 Anime Season! Get your earphones ready for some amazing music. 32 Fantastic Songs to Enjoy! Music Featured In This Episode: -Phantom of the Idol ED2 - "Hare Rarura" (Sunny La Lu La) by Asahi Mogami CV Nao Tōyama -Rent a Girlfriend OP - "Himitsu Koi Gokoro" by CHiCO with HoneyWorks -Lycoris Recoil OP - "ALIVE" by ClariS -Lycoris Recoil ED - "Hana no Tou" by Sayuri -Engage Kiss OP - "Darekare Scramble" by halca -Engage Kiss ED - "Renai Nou" by Akari Nanawo -Prima Doll OP - "Tin Toy Melody" by Chat-noir (cast) -Prima Doll ED2 - "Usuhanazakura" (Faint Cherry-Blossom Pink) by Haizakura CV Azumi Waki -RWBY Ice Queendome OP - "Beyond Selves" by Void_Chords feat. L -RWBY Ice Queendome ED - "Awake" by Saori Hayami -Yurei Deco OP - "1,000,000,000,000,000,000,000,000 LOVE" by Clammbon -Classroom of the Elite 2 OP - "Dance In The Game" by ZAQ -Overlord IV OP - "HOLLOW HUNGER" by OxT -Overlord IV ED Not Full Clean - "No Man's Dawn" by Mayu Maeshima -Harem in the Labyrinth of Another World OP - "Oath" by Roxanne (Shiori Mikami) -Uncle from another World OP - "story" by Mayu Maeshima -Dropkick on my Devil X ED - "Ryuusenkei Mayday" by KAF feat. KAFU -Made in Abyss 2nd Season OP - "Katachi" by Riko Azuna -Made in Abyss 2nd Season ED - "Endless Embrace" by MYTH and ROID -Yakuza's Guide To Babysitting OP - "Mirai no Hero Tachi e" by Takeyaki Shou -Call of the Night OP - "Daten" by Creepy Nuts -Call of the Night ED - "Yofukashi no Uta" by Creepy Nuts -Lucifer and the Biscuit Hammer OP - "Gyouko" by Half time Old -Black Summoner OP - "Atamannaka DEAD END unknown Vo 10fu" by Ret Bear -Shadow House 2 OP - "Shall We Dance?" by ReoNa -Shadow House 2 ED - "Masquerade" by ClariS -Devil is a Part Timer 2 OP - "WITH" by Minami Kuribayashi -AoAshi OP2 - "Presence" by Superfly -Summer Time Rendering OP2 - "Natsuyume Noisy" by Asaka -Summer Time Rendering ED2 - "Shitsuren Song Takusan Kiite Naite Bakari no Watashi wa Mou" by Riria. -Utawarerumono Mask of Truth OP - "Hito Nanda" by Suara -Tokyo Mew Mew NEW ED - "Tokimeki☆Ichigo Ichie" by Smewthie (cast) Tips: https://streamelements.com/otakuspirit/tip Patreon: https://www.patreon.com/OtakuSpirit Merch: https://otaku-spirit.creator-spring.com/ YouTube: https://youtube.com/otakuspirit Discord: https://discord.com/invite/BZ8ZN58u6M Website: https://OtakuSpirit.com

این پادکست را در کانال یوتوب ضیا صدر هم می‌توانید دنبال کنید youtube.com/ziyasadr توی لانه خرگوش محیطی داریم که از فضای شلوغ و سیل گونه اخبار و اتفاقات زرد توی اکوسیستم بیتکوین شما رو دور میکنه و رخدادهای مهم بیتکوین رو بهتون میرسونه هدف ما تو این پادکست اینه که برای علاقه‌مندان به پدیده‌ی بیتکوین، سرمایه‌گذاراش، فعالان این فضا و تمام دوستانی که میخوان درمورد بیتکوین اطلاعات داشته باشن، بروزرسانی داشته باشه و در کنارش مطالبی رو یاد بده. مطالبی که توی این قسمت بهشون میپردازیم - هک ۶۰۰ میلیون دلاری پالی نتورک - لایحه سرمایه گذاری زیرساختی آمریکا و قوانین مرتبط به بیتکوین - همچنین ابزارها و تحقیقات جدیدی توی فضای بیتکوین عرضه شده که به اونا هم می‌پردازیم لینک‌ها - poly network https://twitter.com/PolyNetwork2/status/1425073987164381196?s=20 - infrastructure bill https://bitcoinmagazine.com/search?query=infrastructure+bill - blockstream Greenlight https://blockstream.com/2021/07/21/en-greenlight-by-blockstream-lightning-made-easy/ - OXT research (Samourai Wallet) https://medium.com/oxt-research/understanding-bitcoin-privacy-with-oxt-part-1-4-8177a40a5923 پادکست لانه خرگوش اول هر هفته منتشر میشه کافیه اسم پادکست لانه خرگوش رو به فارسی سرچ کنید همه لینک‌های پلتفرم‌های دیگه‌ی پادکست استریمینگ رو اینجا میتونید پیدا کنید anchor.fm/rhj توییتر سارا https://twitter.com/Saaaar_s توییتر ضیا https://twitter.com/ziya_Sadr

Wondering why the OXT coin is skyrocketing to the moon? Listen to this episode to learn all about the OXT coin and how to trade Orchid in 2021. To get more In Penny Stock content sent directly to your device as they become available, you can subscribe on iTunes or Stitcher! Also, reviews on iTunes are extremely helpful and greatly appreciated! I read each and every one of them, and feel free to share your email there so I can contact you later and say thanks! And lastly, if you have any questions (or would like answers to previously submitted voicemail questions!), head on over to www.inpennystock.com! In addition, for a limited time, we have 2 openings for the InPennyStock VIP Executive Coaching Program where you get direct 1-on-1 penny stock trading strategy plans and access to the exclusive Facebook Mastermind group. If you're interested, email admin@inpennystock.com today. Learn more about your ad choices. Visit megaphone.fm/adchoices

Jacqui Cooper (Host - CryptoMom2 Talk Show) speaks about OXT or Orchid. White paper is listed on their website. Be sure to book a 15 minute Family Crypto Health Consult Check Up to ensure you have everything you need when you do your estate & will planning. This includes a simple, self-guided questionnaire to ensure your peace of mind with a digital copy for you to print and sign to provide to your family. You will receive during the consult the Best 5 Minute Crypto Wallet & Wealth Resource Organizer created by J. Cooper, JD & Crypto Hodler. Be sure to Like & Subscribe to stay up to date with future episodes. This talk show is purely informational and not financial advise. There is always risk on all investments. About Orchid Orchid token (OXT) is a cryptocurrency that runs on the Ethereum blockchain. OXT is used to pay for the VPN services that Orchid provides from anywhere in the world. RESOURCES https://www.orchid.com/

Wondering why the OXT coin is skyrocketing to the moon? Listen to this episode to learn all about the OXT coin and how to trade Orchid in 2021. To get more In Penny Stock content sent directly to your device as they become available, you can subscribe on iTunes or Stitcher! Also, reviews on iTunes are extremely helpful and greatly appreciated! I read each and every one of them, and feel free to share your email there so I can contact you later and say thanks! And lastly, if you have any questions (or would like answers to previously submitted voicemail questions!), head on over to www.inpennystock.com! In addition, for a limited time, we have 2 openings for the InPennyStock VIP Executive Coaching Program where you get direct 1-on-1 penny stock trading strategy plans and access to the exclusive Facebook Mastermind group. If you're interested, email admin@inpennystock.com today. Learn more about your ad choices. Visit megaphone.fm/adchoices

The hosts of the Otaku Spirit Animecast are here to give the rundown on anime news of today. Listen in and get caught up, or just get their take on each piece of news! Topics this episode: Genshin Impact, Super Cub, Censorship in Tokyo Revengers, Key Cross Over Anime, Knights of Sidonia, Healer Girl, The Great Jahy Will Not Be Defeated, AT and T Crunchyroll Update, Belle Film from Mamoru Hosoda, Komi Can’t Communicate, Made in Abyss 2nd Season, Overlord 4th Season, Yen Audio, Yuki Yuna is a Hero 3rd Season, Netflix Sailor Moon Movies, Smile Down the Runway Ending, and much more! Thanks to yehu Satori for the great questions featured in this episode! The opening music for this episode is the OP for Overlord III called “GO CRY GO” by OxT. The closing music for this episode is the ED for Overlord II called “HYDRA” by MYTH＆ROID.

Laurent MT est cofondateur de oxt.me, une plateforme d'analyse de la blockchain Bitcoin et développeur pour Samourai Wallet. Aujourd'hui, nous allons parler des menaces pesant sur le réseau Bitcoin et surtout des plus insidieuses auxquelles on ne pense pas forcément.    Acheter le Ledger Nano X : https://tinyurl.com/3rb3wutx  Acheter, trader du bitcoin sur Paymium : https://tinyurl.com/ne6l18rl  Livre recommandé par Laurent : https://amzn.to/3ewc8VE  Tous les livres recommandés par nos invités : https://universbitcoin.github.io/books    Chapitres :  0:00 Présentation de Laurent MT  6:17 Oxt.me et la vie privée sur Bitcoin  16:47 L'attaque 51 vraiment menaçante ?  25:18 Les deux grandes catégories d'attaque possibles   40:28 Réponses aux critiques classiques des médias  56:00 Le danger de la délégation et du stockage pour autrui  1:10:12 Livre recommandé et film préféré  Notre Twitter :  https://twitter.com/Univers_Bitcoin  Twitter de Laurent MT :  https://twitter.com/LaurentMT  Son site d'analyse de la blockchain Bitcoin :  https://oxt.me

Sketch is joined by VLord, LaserKid and our returning guest Alien Renegade to discuss the second half of SSSS.Gridman and observations of the series as a whole. After that, Paul joins Sketch and LaserKid to talk about Toonami's upcoming schedule changes. Music Credits for this episode: "UNION" as performed by OxT "AKANE SHINJO [Visceral]" as performed by AMPREN (aka Alien Renegade) "Yume no Hero" as performed by Norio Sakai

IS THIS THE FIRST EPISODE OF MECHA MARCH?! DANG RIGHT IT IS BABY LETS GO. We're talking KAIJU, we're talking PILOTING SYSTEMS, we're talking the WHOLE KIT AND THE WHOLE KABOODLE. Join us in our immense hype for mecha animes that we're going to share with you today through SSSS.Gridman! Remember, if you want to watch with us, we watch our Anime of the Month as voted in our discord on Thursday at 4pm central! There's no voice chat so feel free to even sit quietly and watch, or join us in the text chat if you'd like! Discord can be found here: https://discord.gg/EmNmrag Music in this episode is Union by OxT

In today's pod-meal, Myq introduces the concept of "art nuggets" and shared some! As well as some new words that he learned recently that start with "o" and end with "t" and have one letter in between them. (There are TWO such words! Listen and find out! "Out" is not one of them! He knew that one.) Love and thanks to all!

I speak to Ergo about OXT research, why he dedicates his time to Bitcoin and why privacy matters. Ergo gives me some great tips and advice for on chain privacy in this episode and it was great to learn more about what first drew him into the space.  Enjoy. Link to the YouTube video mentioned during the show bellow.  https://www.youtube.com/watch?v=-ztN41Oybd0 twitter - @ErgoBTC website - research.oxt.me   As always please feel free to reach out and ask me any questions.   Website - https://www.bit-buy-bit.com Twitter - @BitBuyBitPod Email - bit-buy-bitpodcast@protonmail.com   Thank you Coinfloor for sponsoring the show. If you haven't signed up or bought Bitcoin then click the link below for 30% off Autobuy fees for 3 months. coinfloor.co.uk/BITBUYBIT

Fala galerinha! Feliz ano novo! Nesse novo ano, mais Anivacilo pra vocês... Yaiy? Voltamos com a série de Jukebox, então senta ai, bota um fone de ouvido e vem ouvir música com a gente! Segue nóis: Twitter do cast: https://twitter.com/anivacilo Twitter dos menine: https://twitter.com/_Krieffer https://twitter.com/Borrachus https://twitter.com/RaulTurnes Nosso canal do Youtube: https://bit.ly/3dftUun Nosso Email para ideias, sugestões e tudo mais: avcastcontato@hotmail.com Links desse episódio: Twitter da Try Hard: https://twitter.com/TryHardSmash Facebook da SGP: https://www.facebook.com/Smashguarulhosplay/ Twitter da SGP: https://twitter.com/SmashGuarulhos Instagram da SGP: https://www.instagram.com/smashguarulhos/ Canal do YouTube da SGP: https://www.youtube.com/channel/UCMPQpVcJJk5bQ3xC4Wa6Yow Twitch da SGP: https://www.twitch.tv/smashguarulhosplay Vídeo do Banjo: https://www.youtube.com/watch?v=kuGpKCg89XI Podcast Solo do Borracha: https://www.youtube.com/watch?v=He-EbMPFErw Músicas do Episódio: Openings: Kanojo Okarishimasu (Rent-a-Girlfriend) - Centimeter – The Peggies: https://youtu.be/eCDJo1rXOW4 Atom the Beginning – Kaidoku Funou – After the Rain: https://www.youtube.com/watch?v=9UN15OgcXno Overlord 2 – Go cry go – OxT: https://www.youtube.com/watch?v=C-43sV-kLM4 Kyokou Suiri (In/Spectre) – Mononoke In The Fiction – Lie and a Chameleon: https://youtu.be/B2qPiSi3rdw GS Mikami – Ghost Sweeper – Chie Harada: https://www.youtube.com/watch?v=O8JvwH4Gpdw Higurashi no Naku Koro Ni – Higurashi no Naku Koro Ni – Eiko Shimamiya: https://www.youtube.com/watch?v=9opZi6PluKI Higurashi no Naku Koro ni Kai OP 2 – Naraku no Hana – Eiko Shimamiya: https://youtu.be/tbVwVvWxv-4 Re: Cutie Honey – Cutie Honey – Kumi Kouda: https://www.youtube.com/watch?v=qwVdhIyGyO4 Sangatsu no Lion 2 OP 1 – Flag wo Tatero – YUKI: https://www.youtube.com/watch?v=bg3n_CIYGao Endings: Yesterday wo Utatte – Kago no Naka ni Tori – Yourness: https://youtu.be/5CklZVlT7Hs Danganrompa – Zetsubousei: Hero Chiryouyaku – suzumu feat. soraru: https://www.youtube.com/watch?v=4l2VCq7MMTA Majo no Tabitabi – Haiiro no Saga – ChouCho: https://www.youtube.com/watch?v=5Z9v2duTkhE Overlord 2 – Hydra – MYTH & ROID: https://youtu.be/Cc-Ecr6Yh2Y Hunter x Hunter (2011) ED 2 – Hunt for your Dream – Galneryus: https://www.youtube.com/watch?v=KuuBhCVJqGI Haikyuu 3 – Mashi Mashi – NICO touches the Walls: https://www.youtube.com/watch?v=cQgRApn4Lf0 Re:Zero kara Hajimeru Isekai Seikatsu – STYX HELIX – MYTH & ROID: https://youtu.be/tIhL2KHVdgE JOJO'S BIZRRE ADVENTURE PART 1 – Roundabout – YES: https://www.youtube.com/watch?v=G65pvuTFR_A K-On Movie – Singing – Hokago Tea Time (Yoko Hikasa): https://www.youtube.com/watch?v=jURZkBYZxEI

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.11.20.392027v1?rss=1 Authors: Witchey, S., Caldwell, H. K. Abstract: Oxytocin (Oxt) signaling via its receptor, the Oxt receptor (Oxtr), is important to the onset of mammalian maternal care. Specifically, evidence suggests that Oxt signaling around the time of parturition underlies the critical shift in how pups are perceived, i.e. from aversive stimuli to rewarding stimuli. Previous work from our lab has found that both Oxtr knockout (-/-) mice and forebrain-specific Oxtr knockout (FB/FB) are more likely than controls to abandon their first litters. Based on these data, we hypothesized that this observed pup abandonment phenotype was due to a failure of the brain to switch to a more maternal state. In order to identify where in the brain Oxt signaling contributes to the onset of maternal care we performed three experiments. In Experiment 1, virgin Oxtr FB/FB females were assessed for genotypic differences in maternal behavior and c-Fos expression following maternal sensitization was quantified. In Experiment 2, c-Fos expression was quantified in Oxtr -/- and Oxtr FB/FB females following parturition. In Experiment 3, based on our findings from Experiment 2, the Oxtr in the nucleus accumbens shell (NAcc) was genetically deleted in female Oxtr floxed mice (Oxtr Flox/Flox) mice using a Cre recombinase expressing adeno-associated virus. In Experiment 1, sensitized virgin Oxtr FB/FB females had significantly lower retrieval latencies on the first day of testing and reduced c-Fos expression in the dorsal lateral septum compared to controls. In Experiment 2, increased c-Fos expression was observed in the NAcc shell of both Oxtr -/- and Oxtr FB/FB dams as compared to controls. In Experiment 3, virally mediated knockout of the Oxtr in the NAcc shell completely disrupted the onset of maternal care. Thus, by genetically deleting Oxtr expression in the NAcc the pup abandonment phenotype previously observed in Oxtr -/- mice and Oxtr FB/FB dams was recreated. Taken together, these data suggest that in post-parturient mice, Oxtr expression in the NAcc shell is critical to the onset of maternal behavior. Copy rights belong to original authors. Visit the link for more info

In this episode we catch up with Deshaun Blunt of @thewillowranchhomestead at Instagram. Check out his YouTube at - https://rb.gy/vsfhau - sponsor the ranch here - https://cash.app/$BluntFamilyEstate - Thanks again to our guest. We took time in this episode to discuss the preliminaries of blockchain, bitcoin, and altcoins. If you are familiar with crypto currency then you may already have a wallet. If not then check out Coinbase; Coinbase Links; * Join Coinbase & Earn $10 USD in BTC; https://bit.ly/2G9hzN8 · Earn $59 USD in COMP; https://bit.ly/35Lia0v · Earn $50 USD in XLM; https://bit.ly/37Sp4na · Earn $50 USD in EOS; https://bit.ly/3oDASjd · Earn $40 USD in OXT; https://bit.ly/2JrraAm · Earn crypto while learning about crypto! · Discover how specific crypto currencies work and get a bit of each crypto to try out for yourself. Its that easy! Sign up today! · Don't miss out on this great opportunity. · Thank you for supporting this podcast. Happy holidays. Stay stay. Stay healthy. Stay informed. #BlackFriday #CyberMonday #StonerBaby #Coinbase #stellar #orchid #compound #eosio #bitcoin #altcoin #happyholidays --- Send in a voice message: https://anchor.fm/stonerbabymedia/message Support this podcast: https://anchor.fm/stonerbabymedia/support

On the fifth episode of the Bridge to Bridge podcast we link up with Orchid Protocol CEO Dr. Steven Waterhouse - AKA "Seven". We discuss Dr. Waterhouse's early years in crypto as a partner at Pantera Capital, we break down Bitcoin and Crypto to every day listeners, and dive into Orchid's attempts to bridge the VPN and blockchain space with their coin, OXT. Dr. Waterhouse expands upon his path to where he is today, some favorite crypto projects in the bay area, and the future of crypto's role in society.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.08.330993v1?rss=1 Authors: Nunes, A. R., Gliksberg, M., Varela, S. A. M., Teles, M., Wircer, E., Blechman, J., Petri, G., Levkowitz, G., Oliveira, R. F. Abstract: Hormones regulate behavior either through activational effects that facilitate the acute expression of specific behaviors or through organizational effects that shape the development of the nervous system thereby altering adult behavior. The neurohormone oxytocin (OXT) has an activational role in several aspects of social behavior, including social processing, attention and reward, in rodents and humans. Previously, we showed that this activational role of OXT is evolutionarily conserved in deep time, since OXT also modulates perception of visual social cues and social recognition in zebrafish. In contrast, the organizational action of OXT neurons in maturation of distinct neural systems necessary for social behavior remains less explored. Here, we show that in zebrafish, OXT is required during early life for the display of social affiliation in adulthood. Perturbation of OXT neurons during early development led to a loss of dopaminergic neurons, associated with visual processing and reward, and altered the neuronal response to social stimuli in the preoptic area and the ventral telencephalon of the adult brain. Ultimately, adult fish which were ablated in early life, displayed altered functional connectivity within social decision-making brain nuclei both in naive state and in response to social stimulus and became less social. We propose that OXT neurons have an organizational role, namely to shape forebrain neuroarchitecture during development and to acquire an affiliative response towards conspecifics. Copy rights belong to original authors. Visit the link for more info

This week Marty and Matt discuss: - Ongoing bsv dust attack - OXT research alleged wasabi vulnerability - Strike adds cashback - Hash rate hits ATH then floods in Sichuan - Tor statement on recent exit node attacks - Tor proposal for possible DoS mitigations - cypherpunklabs.com allows you to easily fund Tor nodes - BitMEX adding KYC - Specter v0.6.1 - myNode v0.2.14 - Zeus v0.3.1 - BTCPay Server v1.0.5.5 - Lily Wallet v1.0.0 - lnd v0.11-beta - Schnorr explainer series by suredbits - Raspiblitz on bitcoinmagazine stream - Lancium sues Layer 1 - BlockFi raises $50M, rumored valuation of $400M - Cryptovoices monetary base update Shoutout to our sponsors: Unchained Capital. Check out their white glove vault concierge service that will take you from zero to secure multisig setup in no time. Use the code TFTC and receive $50 off that package that includes 2 Trezor Model Ts and $1,000 in your vault. Cash App. Start #stackingsats today. Use the promo code: "stackingsats" to receive $10 and contribute $10 to OWLS Lacrosse when you download the app.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.19.255844v1?rss=1 Authors: Winter, J., Meyer, M., Berger, I., Peters, S., Royer, M., Bianchi, M., Stang, S., Langgartner, D., Reber, S. O., Kuffner, K., Schmidtner, A. K., Hartmann, F., Bludau, A., Bosch, O. J., Slattery, D. A., van den Burg, E. H., Neumann, I. D., Jurek, B. Abstract: Recently, oxytocin (OXT) has generated considerable interest as potential treatment for psychiatric disorders, including general anxiety disorder or autism spectrum disorder. Therefore, knowledge on the involved molecular processes downstream of OXT receptor (OXTR) activation is indispensable. We reveal that alternative splicing of corticotropin releasing factor receptor 2a (CRFR2a) parallels increased anxiety-like behavior following chronic OXT treatment, contrasting the well-known anxiolysis of acute OXT. In detail, chronic OXT shifts the splicing ratio between membrane-bound (mCRFR2a) and soluble CRFR2a (sCRFR2a) in favor of the latter via ERK1/2-MEF2A signaling. Targeted manipulations of Crfr2a splicing mimic the effect of chronic OXT, confirming its role in the regulation of anxiety-like behavior. Furthermore, chronic OXT triggers cytoplasmic distribution and extracellular release of sCRFR2a into the cerebrospinal fluid, with sCRFR2a levels positively correlating with anxiety-like behavior. Concluding, the dichotomy between anxiolytic mCRFR2a and anxiogenic sCRFR2a is the basis for the deleterious effects of chronic OXT on anxiety. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.07.241364v1?rss=1 Authors: Jurado, S., Madrigal Verdu, M. P. Abstract: Oxytocin (OXT) and arginine vasopressin (AVP) support sex-specific and context-appropriate social behaviors. Although alterations of these systems underlie the appearance of neuropsychiatric disorders, their formation and developmental dynamics remain largely unknown. Using novel brain clearing techniques and 3D imaging, we have reconstructed the specification of oxytocinergic and vasopressinergic circuits in the developing mouse brain with unprecedented cellular resolution. A systematic quantification indicates that OXT and AVP neurons in the hypothalamus display distinctive dynamics, but also share common features as a high cellular plasticity from embryonic to early postnatal stages. Our findings reveal new insights into the appearance and consolidation of neuropeptidergic systems in the developing CNS which is a critical step to unveil brain formation and function. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.07.28.224873v1?rss=1 Authors: Oliveira, V. E. d. M., Lukas, M., Wolf, H. N., Durante, E., Lorenz, A., Mayer, A.-L., Bludau, A., Bosch, O. J., Grinevich, V., Egger, V., de Jong, T. R., Neumann, I. D. Abstract: In contrast to males, aggression in females has been rarely studied. Here, we established a rat model of enhanced female aggression using a combination of social isolation and aggression-training to specifically investigate the involvement of the oxytocin (OXT) and vasopressin (AVP) systems within the lateral septum (LS). Using neuropharmacological, optogenetic, chemogenetic as well as microdialyses approaches, we revealed that enhanced OXT release within the ventral LS (vLS), combined with reduced AVP release within the dorsal LS (dLS), are required for female aggression. Accordingly, increased excitability of OXT-responsive neurons in the vLS and decreased excitability of AVP-responsive neurons in the dLS were essential to evoke female aggression. Finally, in vitro activation of OXT receptors in the vLS increased tonic GABAergic inhibition of dLS neurons. Overall, our data demonstrate that septal release of OXT and AVP affects female aggression by differential regulation of the excitatory-inhibitory balance within subnetworks of the LS. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.07.14.202598v1?rss=1 Authors: Mignocchi, N. L., Kruessel, S., Jung, K., Lee, D., Kwon, H.-B. Abstract: Oxytocin (OXT) is a neuropeptide originating in the paraventricular nucleus (PVN) of the hypothalamus, with a role in influencing various social behaviors. However, pinpointing its actions only during the time animals are performing specific behaviors has been difficult to study. Here we developed an optogenetic gene expression system designed to selectively label neuronal populations activated by OXT in the presence of blue-light, named OXTR-iTango2. The OXTR-iTango2 was capable of inducing gene expression of a reporter gene in both human embryonic kidney (HEK) cells and neurons in a quantitative manner. In vivo expression of OXTR-iTango2 selectively labeled OXT-sensitive neurons in a blue-light dependent manner. Furthermore, we were able to detect a subset of dopamine (DA) neurons in the ventral tegmental area (VTA) that receive OXT activation during social interaction. Thus, we provide a genetically-encoded, scalable optogenetic toolset to target neural circuits activated by OXT in behaving animals with a high temporal resolution. Copy rights belong to original authors. Visit the link for more info

Zilliqa (ZIL) Turns to TikTok After DogeCoin's Success. VeChain: Hotel giant InterContinental adopts MyCare – Binance US adds staking. Orchid token (OXT) up 11% on VPN app Apple store debut. Donate Here to support the channel! Crypto.com referral: ev2k386tnh BTC Address: bc1qf43hcj6q50tauakey33p796rwxvlrcsgyhp7ue LTC Address: LMQKwrNzSBS9xfp8gSwAu1yBnWkjvJYZ1q Links to articles discussed: https://en.ethereumworldnews.com/tron-trx-zilliqa-zil-turn-to-tik-tok-after-dogecoins-success/ https://www.crypto-news-flash.com/vechain-hotel-giant-intercontinental-adopts-mycare-binance-us-adds-staking/ https://decrypt.co/35219/orchid-vpn-oxt-token-apple-app-store https://en.ethereumworldnews.com/chainlink-link-will-be-bigger-than-bitcoin-btc-crypto-analyst/ https://www.coindesk.com/coinbase-plans-first-ever-investor-day-amid-talk-it-may-go-public https://decrypt.co/35210/ethereum-2-0-delayed-vitalik-buterin-disagrees https://decrypt.co/35275/active-ethereum-addresses-growing-twice-as-fast-as-bitcoin https://decrypt.co/35258/defi-alliance-adds-more-startups-industry-growth-accelerates https://cryptopotato.com/elrond-erd-skyrockets-another-daily-50-following-integration-of-swingby/ https://www.coindesk.com/crypto-giveaway-scams-continue-to-flourish-on-youtube --- Support this podcast: https://anchor.fm/cryptotop10/support

Here are the top cryptocurrency news headlines from India this week:WRX listed on Poloniex: https://blog.wazirx.com/wrx-is-listed-on-poloniex/ ;1st Quarter WRX Burn Event: https://blog.wazirx.com/1st-quarter-wrx-burn-event/ ;CoinDCX launches 24x7 customer support: https://blog.coindcx.com/24x7-support-available-now/ ;Orchid(OXT) is now listed on CoinDCX: https://blog.coindcx.com/orchid-oxt-is-now-listed-on-coindcx/ ;Bitbns lists new Fixed Income Plan for USDT. Reading suggestion for the week:DeFi is ready for India, but are Indian authorities ready for crypto?: https://decrypt.co/33325/defi-is-ready-for-india-but-are-indian-authorities-ready-for-crypto

Episode 37:    Welcome to this week’s episode. We continue the tech trend and shift to Bit Coin investigations. Nick Himonidis from the NH Group returns to dig deeper into how these investigations work. There is a great deal of knowledge packed into this week’s show.       CROSStrax, Delvepoint and Investigators-toolbox.com sponsor the show this week.            Links:     Matt’s email: MatthewS@Satellitepi.com  Linkedin: Matthew Spaier    Nicks Phone: (516) 621-6500 Nicks email: nhimonidis@theNGHgroup.com Linkedin: Nick Himonidis BITCOIN STUFF: • BTC addresses start with the character 1 or 3, are 34 characters long, and are formatted as Base58. EXAMPLE: 1AMdziK76JwP6DzEGyB9ruddBxQhM1oeZE • Blockchain Explorers (where you can enter a BTC Address and get lots of information about that address): • https://www.blockchain.com/explorer • OXT.ME • Free BTC Address analysis and visualization tool: • Numisight   Sponsors:            https://www.crosstrax.co/    https://delvepoint.com/ https://investigators-toolbox.com/

In this episode of CoinList Chats, CoinList President & Co-Founder Andy Bromberg sat down with Orchid Labs CEO and Co-Founder, Dr. Steven Waterhouse (SEVEN) to discuss: - What is Orchid - The origins and motivation behind the project - How the VPN works - What role the OXT token plays in the network - Traction and adoption to date - Plans for the future About Orchid: Orchid takes a new approach to digital privacy by enabling the first peer-to-peer, incentivized virtual private network (VPN). On the network, anyone can buy and sell bandwidth from a global pool of service providers using the Orchid digital currency (OXT). Users can browse privately and access content without being limited by their geography. Links:  CoinList: https://coinlist.co/ Orchid: https://www.orchid.com/ Andy Bromberg: https://twitter.com/andy_bromberg Dr. Steven Waterhouse: https://twitter.com/deseventral Email team@coinlist.co with things you'd like to see covered in future CoinList Chats. Legal disclaimer: This podcast was recorded and is being distributed by Amalgamated Token Services Inc., dba CoinList, for informational purposes only, and expresses solely the opinions of the speakers, not necessarily those of CoinList. Nothing in this podcast shall constitute or be construed as an offering of securities or as investment, legal or tax advice or investment recommendations (i.e., recommendations as to whether or not to enter into any transaction involving any specific interest or interests) by CoinList or any of its affiliates, or a recommendation as to an investment or other strategy. These types of investments involve a high degree of risk (including the risk of total loss) and potential investors should consult with their own advisors. CoinList does not receive compensation for publishing, giving publicity to, or circulating notices or communications that describe securities.  

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.05.20.105684v1?rss=1 Authors: Liu, C., Lan, C., Li, K., Zhou, F., Yao, S., Xu, L., Yang, N., Yang, J., Yong, X., Ma, Y., Scheele, D., Kendrick, K. M., Becker, B. Abstract: Overarching conceptualizations propose that the complex social-emotional effects of oxytocin (OXT) in humans are partly mediated by interactions with other neurotransmitter systems. Recent animal models suggest that the anxiolytic effects of OXT are critically mediated by the serotonin (5-HT) system, yet direct evidence in humans is lacking. To determine the role of 5-HT in OXT-induced attenuation of amygdala threat reactivity and sensitization/ desensitization, 121 healthy subjects underwent a transient decrease in 5-HT signaling via acute tryptophan depletion (ATD) before the administration of intranasal OXT or the corresponding placebo-control protocols, respectively. Mean and repetition-dependent changes in threat-specific amygdala reactivity towards threatening stimuli (angry faces) as assessed by fMRI served as the primary outcome. No treatment main or interaction effects on amygdala threat reactivity were observed, yet OXT switched bilateral superficial amygdala sensitization to desensitization and this effect was significantly attenuated during decreased central 5HT signaling via pretreatment with ATD. The present findings provide the first evidence for a role of OXT in threat-specific amygdala desensitization in humans and suggest that these effects are critically mediated by the 5-HT system. Copy rights belong to original authors. Visit the link for more info

A full break down of my thought on OXT what price it could hit, when all the investor coins come unlocked and decentraland wearables supply talk

Wszystkie dobre podcasty o kryptowalutach https://darmowekrypto.org.pl/podcasty-----------------------------------------NewsFlash | 13.04.2020 | BTC Halving, Craig Wright wycofał pozew, Binance i opcje, Gemini do BAT, DAI, LINK, OXTBitcoin halving nadchodzi wielkimi krokami i został do niego już 30 dni. Coraz więcej osób wróży z fusów na temat ceny króla kryptowalut, a górnicy opracowują własne strategie. Wiadomo jedno: nagroda za blok spadnie o połowę, do 6.25 BTCGiełda Gemini zaczyna dodawać nowe tokeny. Już 24-go kwietnia dodane zostaną 4 nowe kryptowaluty: BAT, LINK, DAI i OXT. Czy ich ceny poszybują w górę. A dodatkowo giełda Binance wprowadził obsługę opcji na Bitcoinie w swojej mobilnej aplikacji. Zapraszam na kolejne wydanie szybkich wiadomości ze świata kryptowalut i technologii blockchain. Same ciekawe informacje i bez wtopy jak w szkole TVP. W dzisiejszym odcinku:- Parlament Europejski zamierza rozszerzyć regulacje dotyczące kryptowalut - https://bitcoinpl.org/parlament-europejski-zamierza-rozszerzyc-regulacje-dotyczace-kryptowalut/- Binance dodaje obsługę opcji do swojej aplikacji mobilnej - https://cointelegraph.com/news/binanc...- Craig Wright wycofuje pozew i płaci koszty sądowe - https://cointelegraph.com/news/craig-...- Justin Sun oskarżony o przekupstwa i manipulacje aby przejąć Steem - https://cointelegraph.com/news/justin...- Geminin doda 4 nowe kryptowaluty - https://cointelegraph.com/news/gemini...- Kolejne wydanie chińskiego rankingu kryptowalut - https://cointelegraph.com/news/chines...- Strategia na halving bitcoina - https://www.coindesk.com/bitcoin-halv...- Można wysłać BTC bez internetu - https://cryptogazette.com/2020/04/13/...- Celsius obniża minimalną kwotę pożyczki - https://coinfomania.com/celsius-reduc...- Ripple o przyszłości rynku płatności - https://dailyhodl.com/2020/04/13/ripp...- Ross Ulbricht o cenie BTC - https://dailyhodl.com/2020/04/13/ross...- Tecent i Alibaba złożyły 20% wszystkich wniosków patentowych w 2019 roku - https://www.theblockcrypto.com/linked...-----------------------------------------OFICJALNY SKLEP Z GADŻETAMI KANAŁU MIKE SATOSHI http://kryptonarod.store/ZOSTAŃ PATRONEM KANAŁU MIKE SATOSHI https://patronite.pl/mike-satoshi-----------------------------------------Jeżeli chciałbyś wesprzeć rozwój i działania kanału, możesz przekazać dotację: https://tipanddonation.com/mikesatoshi lub PayPal: paypal.me/mikesatoshi Portfele do dotacji krypto są tutaj: https://cryptokoks.wixsite.com/mikesatoshi/dotacje ----------------------------------------- Mój kanał na YouTube: https://www.youtube.com/channel/UCEX4iDKLfxtIJY6IVgMSqCQE-mail do kontaktu: cryptokoks@gmail.com Oficjalny Twitter: https://twitter.com/Mikey_Satoshi Kanał na DTube: https://d.tube/#!/c/mikesatoshi Grupa KryptoNaród na FB: https://www.facebook.com/groups/230649241027530/ Grupa KryptoNaród na Discord: https://discord.gg/CPTSa43 Airdropy i inne sposoby na darmowe kryptowaluty: https://darmowekrypto.org.pl -----------------------------------------

Many in the West often look to privacy preserving technologies like Orchid’s virtual private network (VPN) marketplace as enablers of nefarious activities. Go to a place like Indonesia, where 43% of the population uses VPNs to circumvent an overly censored internet and government surveillance of basic business activities, and you’ll get a different opinion. For protesters in places like Hong Kong, VPNs can serve as freedom preserving technology.  In this conversation, Orchid CEO Seven Waterhouse details the project's plans for creating an internet free from surveillance and censorship. Ryan and Seven discuss the evolution of the project, the role its OXT token plays in the network as well as Orchid’s unique listing on Coinbase. They also get into the origins of Seven’s peculiar nickname.    --- Special thanks to our sponsors Nexo: Borrow, lend and grow your crypto. Lukka: Crypto taxes made simple. Use the code messaritax and get $5 off the normal price of $19.95  If you enjoyed this conversation, share it with your colleagues & friends, rate, review, and subscribe.This podcast is presented by BlockWorks Group. For exclusive content and events that provide insights into the crypto and blockchain space, visit them at: https://www.blockworksgroup.io

Orchid is building open source tools for custom VPN configurations and privacy services. CEO Steven Waterhouse talks about the vulnerabilities of today’s VPNs, the purpose of OXT, and shares his experience with being SIM swapped.

Conheça o explorador de blocos OXT, uma poderosa ferramenta para você criar suas próprias análises da blockchain Bitcoin e ajudar a identificar carteiras de corretoras, instituições, governos e empresas que movimentam fundos de terceiros. Mais uma poderosa ferramenta para o povão que usa o BTC, no último episódio desta série especial de Samourai com o urso Dov. Vídeo na íntegra: https://youtu.be/JgYDk8NI_cg Explorer OXT: https://oxt.me Momentos históricos do Bitcoin: https://oxt.me/history Carteira Samourai: https://samouraiwallet.com/ SIGA O DOV: https://www.twitter.com/bitdov SIGA OS BITCOINHEIROS: https://www.youtube.com/bitcoinheiros https://anchor.fm/bitcoinheiros https://www.twitter.com/bitcoinheiros https://www.instagram.com/bitcoinheiros Bitcoinheiros recomendam: Carteira Trezor para fazer a segurança das suas criptomoedas. Usando este link você ajuda o canal: https://shop.trezor.io/?offer_id=10&aff_id=1135 ISENÇÃO DE RESPONSABILIDADE: Este conteúdo foi preparado para fins meramente informativos. NÃO é uma recomendação financeira nem de investimento. As opiniões apresentadas são apenas opiniões. Faça sua própria pesquisa. Não nos responsabilizamos por qualquer decisão de investimento que você faça. #Bitcoin

ORIGINALLY RECORDED DECEMBER 31ST, 2018 A new year has arrived, and with it many new anime for fans to binge and enjoy. Before we get too under way with 2019, Dub Talk is here to revisit anime from 2018. The OG hosts, plus one coincidental extra host, have gathered on New Year's Eve to talk about their, and everyone else's, favorites of the past year. There will be plenty of laughs and buckets of tears. Welcome to Dub Talk's fourth annual Dubbie Awards show! Like what we do? Support us on Patreon! https://www.patreon.com/dubtalkpodcast Or consider buying us a Ko-fi! https://ko-fi.com/dubtalk DUB TALK SOCIAL MEDIA Twitter: @DubTalkPodcast Instagram: @dubtalkpodcast Twitch: dubtalkpodcast Tumblr: dubtalkpodcast HOSTS @LilacAnimeRevue @SpacemanHardy @queenira2 @Mangaman9000 EDITORS @LilacAnimeRevue @NoahClue 0:00 - Disclaimer 2:01 - Introductions 5:58 - Underrated Performance Award 27:04 - Voice Actor to Watch 43:15 - Golden Ham Award 58:28 - Best Sound Mixing 1:09:56 - Voice Acting Black Magic Award 1:22:47 - Unsung Hero Award 1:26:28 - Best Female Performance (Comedy) 1:38:38 - Best Male Performance (Comedy) 1:53:50 - Viewer's Choice Award - Best Actress WINNER 1:55:30 - Best Female Performance (Drama) 2:10:18 - Best Male Performance (Drama) 2:34:36 - Viewer's Choice Award - Best Actor WINNER 2:35:56 - Best Ensemble Cast 2:47:42 - Viewer's Choice Award - Best Returning Actor WINNER 2:49:49 - Best Writing 3:03:13 - Best Director 3:18:36 - Viewer's Choice Award - Sequel Dub of the Year WINNER 3:20:16 - Dub of the Year 3:40:30 - Viewer's Choice Award - Dub of the Year WINNER MUSIC (INSTRUMENTALS) "Red Swan" by YOSHIKI feat. HYDE "VORACITY" by MYTH & ROID "Stray" by Kishida Kyōdan & The Akeboshi Rockets "Tsuki no Mō Hanbun" (The Moon is Already a Half Moon) by AIKI&AKINO from Bless4 "Union" by OxT "katharsis" by TK from Ling Tosite Sigure "Pray" by Haruka Chisuga "Iwanai kedo ne" by Yuiko Ōhara "PARADOX" by QUADRANGLE "Sincerely" by TRUE "Hanamaru In no Hi no Moto de" by Mitsuhiro Ichiki &Toshiki Masuda "Binary Star" by SawanoHiroyuki[nZk] with Uru "POP TEAM EPIC" by Sumire Uesaka "Fatima" (ファティマ) by Kanako Itou "Adabana Necormancy" (Fruitless Necromancy) by Asami Tano, Kaede Hondo, Maki Kawase, Minami Tanaka, Rika Kinugawa, & Risa Taneda "Go Cry Go" by OxT "Michishirube" (Guidepost) by Minori Chihara "Rocket Beat" by Kiyono Yasuno "Update" by miwa "You" by May'n "LAST GAME" by Zwei "CLEAR" by Maaya Sakamoto "Otomodachi Film" (オトモダチフィルム) by Masayoshi Ōishi "Tō no Manimani" (灯火のまにまに) by Nao Tōyama "Fly Me to the Star" by Starlight Kuku-gumi "High Stepper" by Yuiko Ohara "The Perfect World" by Jean Ken Johnny, Marty Friedman, KenKen & Koji Fujimoto "Make my story" by Lenny Code Fiction "DREAMCATCHER" by Nano "Hoshi no Dialogue" (Stellar Dialogue) by Starlight Kukugumi "Futari no Hane" by YURiKA "Kiss of Death" by Mika Nakashima & Hyde "Devilman no Uta" (Devilman's Song) by Avu-chan "Guess Who Is Back" by Kumi Koda "Winding Road" by MAN WITH A MISSION "Rightfully" by Mili "Deep in Abyss" by Miyu Tomita & Mariya Ise "The Beginning" by Yohsuke Yamamoto "Reimei" by Sayuri and MY FIRST STORY "Deal with devil" by Tia "Little Soldier" by Azusa Tadokoro "My Generation" by The Who "LET'S POP TOGETHER" by Kenji Akabane & Shunsuke Takeuchi "Dirty Bullet" by Tri4th "Danger in my Tsūgakuro" (Danger in My School Commute) by Naomi Ōzora, Chiaki Omigawa, & Kaede Hondo "BREATHE AGAIN" by JAMOSA feat. Sphere "Hikari e" (To the Light) by Asami Tano, Kaede Hondo, Maki Kawase, Minami Tanaka, Rika Kinugawa, & Risa Taneda "Another colony" by TRUE "Howling" by FLOW x GRANRODEO "Gravitation" by Maon Kurosaki "Kimi ni Furete" (君にふれて) by Riko Azuna "TRASH CANDY" by GRANRODEO "Gamushara" by Miyuna "FLIP FLAP FLIP FLAP" by TO-MAS feat. Chima "Utata ne Sunshine" (うたたねサンシャイン; Snooze Sunshine) by Unlimited tone "Heart Signal" (ハートシグナル) by Wataru Hatano "Namae wo Yobu yo" (名前を呼ぶよ; Call Out The Name) by Luck Life

The not-so perfect heroes, the bad guys you learn to love, and the moral dilemmas it creates. Join the hosts as they discuss Anti-Heroes and Villains and their increase in favorability as main characters in anime. Topics this episode: Heroes, Villains, Sympathetic Villains, Anti-Heroes, Cause and Effect, Storytelling, Crossing the Line of Villains, and individual show examination. The opening for this episode is the OP for Overlord 2 called “GO CRY GO” by OxT. The closing for this episode is the OP for Saga of Tanya the Evil called “JINGO JUNGLE” by MYTH and ROID.

Do you remember the early nineties? Remember Bill Clinton on Arsenio Hall? The Simpsons around the time it got good and well before it stopped? Dub Talk remembers, and Roots leads a ragtag group across the reimagining of a Tokusatsu series from his childhood, SSSS.GRIDMAN. Does it live up to his nostalgia or are some memories best left in the past? Find out today. Like what we do? Support us on Patreon! https://www.patreon.com/dubtalkpodcast Or consider buying us a Ko-fi! https://ko-fi.com/dubtalk DUB TALK SOCIAL MEDIA Twitter: @DubTalkPodcast Instagram: @dubtalkpodcast Twitch: dubtalkpodcast Tumblr: dubtalkpodcast HOSTS @rootsofjustice @divinenega @jamstar529 @Mangaman9000 EDITOR Rootsofjustice MUSIC Superhuman Samurai Syber Squad theme song composed by Mark Simon Union by OxT feat. Tom Hack youthful beautiful by Maaya Uchida Yume no Hero by Norio Sakai Gridman the Hyper Agent OST Selections by Osamu Totsuka

Wrapping up the Summer 2018 Anime Season, the hosts of the Otaku Spirit Animecast are here with the final selection of shows to review and give their perspective. Lots of Season 3s and the validity of strengths to be discussed! Anime Reviewed in this Episode: Yuuna and the Haunted Hot Springs, Hanebado, Revue Starlight, Asobi Asobase, Encouragement of Climb 3, Overlord 3, My Hero Academia 3, and comments about Attack on Titan 3 and Banana Fish. Following the spoiler free reviews of each of the shows and the outro music, we enjoy a spoiler filled discussion of Revue Starlight and Overlord 3. If you have not watched Revue Starlight, avoid listening between 1:58:16 and 2:07:04. If you have not watched Overlord 3, avoid listening between 2:07:04 and 2:14:10. The opening song for this episode is the OP for Overlord 3 called “VORACITY” by Myth and Roid. The closing song for this episode is the ED for Yuuna and the Haunted Hot Springs called “Happen Kogarashi ni Fukarete” by the cast. The song following the spoiler discussion is the ED for Overlord 3 called “Silent Solitude” by OxT.

While not a heavy last few weeks in regards to news, the hosts of the Otaku Spirit Animecast are still here to give the download of important pieces. At least for themselves. New adaptations, returning legends, and more! Topics this episode: Bakemonogatari Manga, Overlord 3 Music, Oshi ga Budokan Ittekuretara, Yamishibai Japanese Ghost Stories, Kenichi Sonada Kickstarter, March Comes In Like A Lion Dub, Valve Versus Visual Novels, Crunchyroll Licenses, FLCL Progressive, Mitsuo Iso New Project, Fairy Tale Girls, Ueno-san wa Bukiyou Anime, KADO on YouTube, Harukana Receive, Muv Luv Vita, Cells at Work, Eri Takenashi, Scum’s Wish, K Series Film, and much more! Thanks to MojaveRena, fragoff, BlueSpark, and Kocurek1944 for the great questions featured on this episode. The intro music for this episode is the OP for Overlord Season 2 called “GO CRY GO” by OxT. The outro for this episode is the ED for Overlord Season 1 called “L.L.L.” by MYTH and ROID.

The hosts of the Otaku Spirit Animecast are back for their second batch of Winter 2018 anime reviews. Jumping into campers, undead kings, romantic co-workers, honey badgers, moe kaiju, and more! Anime Reviewed in this Episode: After The Rain, Junji Ito Collection, The Ancient Magus’ Bride, GARO Vanishing Line, Laid-Back Camp, Killing Bites, Overlord II, and Kaijuu Girls 2nd Season. The opening song for this episode is the OP for Overlord II called “GO CRY GO” by OxT. The closing song for this episode is the ED for After the Rain called “Ref:rain” by Aimer.

Warm yourself up in the Winter 2018 season with some great tracks picked by the hosts of the Otaku Spirit Animecast. The best OPs and EDs of the season are here to fill your ears while the hosts inform you of the artists that are behind them. Songs spotlight in this episode: “Watashi no Tame no Monogatari” by fhana – Maerchen Maedchen OP “SHINY DAYS” by Asaka – Laid-Back Camp OP “Furu Biyori” by Eri Sasaki – Laid-Back Camp ED “GO CRY GO” by OxT – Overlord 2 OP “HYDRA” by Myth and Roid – Overlord 2 ED “Iwanai kedo ne” by Yuiko Oohara – Karakai Jozu no Tagaki-san OP “Korekara” by Machico – The Ryuo’s Work is Never Done OP “You” by May’n – The Ancient Magus’ Bride OP2 “Haru ga Kite Bokura” by UNISON SQUARE GARDEN – March Comes In Like A Lion 2 OP2 “Pop Team Epic” by Sumire Uesaka – Pop Team Epic OP “KISS OF DEATH” by Mika Nakashima x Hyde – Darling in the Franxx OP “Azalea” by nano.RIPE – Citrus OP “Stray” by Kishida Kyoudan and the Akeboshi Rockets – Hakata Tonkotsu Ramens OP “Urar” by Chima – Hakumei and Mikochi OP “Nostalgic Rainfall” by CHiCO with Honeyworks – After the Rain OP “Ref:rain” by Aimer – After the Rain ED “Error” by GARNiDELiA – Beatless OP “PRIMALove” by ClariS – Beatless ED “Flashback” by Miyavi vs KenKen – Kokkoku OP “Asayake to Nettaigyo” by Boku no Lyric no Bouyomi “Colors Power ni Omakasero” by the cast – Mitsuboshi Colors ED

After a few weeks, the hosts of the Otaku Spirit Animecast are back for yet another discussional podcast episode to cover the news and catch up on the community at large. Topics this episode: Toei profits, Kakuriyo no Yadomeshi adaptation, Tatsuki recruiting new project, Ellation Malware announcement, Angel Beats out of print, Keiichi Hara new project, Fate Apocrypha on Netflix, Disastrous Life of Saiki K season 2, Kud Wafter Global Success, Netflix Erased release, Attack on Titan Season 3, Fate GO artist’s exodus, Hinamatsuri anime, Visual Arts crowdfunding for VR Planetarian, Hiromi Tsuru passing, Overlord 2 themes, Sega revealing new Valkyria project, Yuuna and the Haunted Hot Springs anime, Right Stuf Gundam news, Fist of the North Star eBook, Anime in Oscars, Utawarerumono game remake, Welcome to the Ballroom passes manga, misquoted directors, licenses, and much more! Thanks to BlueSpark, NativeAbearican, Ledah013, and Companion Kyuubey for the great questions featured in this episode! The intro music for this episode is the OP for Outbreak Company called “Univer Page” by Suzuko Mimori. The outro music for this episode is the ED for Space Dandy called “X Jigen e Youkoso” by Etsuko Yakushimaru.

Warm off the chill of Winter with a run through of Winter 2017 Anime’s best musical offerings. Join the hosts of the Otaku Spirit Animecast as they give their picks for the season and discuss the artists behind them! NOTE: For High Quality purposes for music, this podcast was exported via HQ setting, thus slightly larger in size than standard podcasts. Roughly 96MB. Keep that in mind for bandwidth limits please. Songs spotlight in this episode: “Go” by Bump of Chicken – Grandblue Fantasy The Animation OP “Sora no Parade” by HARUHI – Grandblue Fantasy The Animation ED “Kimi no Hana” by Hanako Oku – Seiren OP “Imawa no Shinigami” by Megumi Hayashibara – Showa Genroku 2 OP “Itteki no Eikyou” by UVERworld – Blue Exorcist Kyoto Saga OP “Climber’s High!” by Manami Numakura – Fuuka OP “Watashi no Sekai” by Megumi Nakajima – Fuuka ED “JINGO JUNGLE” by MYTH and ROID – Saga of Tanya the Evil OP “Los! Los! Los!” by Tanya (Aoi Yuuki) – Saga of Tanya the Evil ED “Elemental World” by ChouCho – Masamune-kun’s Revenge ED “TOMORROW” by Machico – KONOSUBA 2 OP “Uncontrollable” by Kanako Itou – Chaos;Child OP “Chaos Syndrome” by Konomi Suzuki – Chaos;Child ED “Aozora no Rhapsody” by fhana – Miss Kobayashi’s Dragon Maid OP “Rirai Mirai” by MimimemeMimi – Akiba’s Trip The Animation ED2 “One Hand Message” by OxT (Masayoshi Oishi x Tom-H@ck) – Hand Shakers OP “Shadow and Truth” by ONE III NOTES (one third nodes) – ACCA OP “Original” by TrySail – Interview With Monster Girls OP “Illuminate” by Minami Kuribayashi – Tales of Zestiria the X 2 OP “INNOSENSE” by FLOW – Tales of Zestiria the X 2 ED “Fighter” by KANA-BOON – Mobile Suit Gundam Iron-Blooded Orphans 2 OP2 “Uso no Hibana” by 96neko – Scum’s Wish OP “Heikousen” by Sayuri – Scum’s Wish ED “Sayonara Bystander” by YUKI – March Comes In Like A Lion OP2 “orion” by Kenshi Yonezu – March Comes In Like A Lion ED2 “Nyako is Love” by Everyhearting – Nyanko Days ED

Warm yourself during this Winter Season with the top picks of Openings and Closings from the Otaku Spirit Animecast. In this Musical episode, we highlight the best tracks brought to us from the talented people who either get us prepared for our shows, or ramp us down from our adventures! Songs spotlight in this episode: “Ashita o Orase” by Kavka Shishido – Fairy Tail Zero OP “Landscape” by SOLIDEMO – Fairy Tail Zero ED “Survivor” by BLUE ENCOUNT – Mobile Suit Gundam: Iron-Blooded Orphans OP2 “STEEL -Bonds of Blood and Iron-” by TRUE – Gundam: Iron-Blooded Orphans ED2 “Strider’s High” by OxT – Prince of Stride: Alternative OP “Contrail~Miracle~” by Mami Kawada – AOKANA: Four Rhythm Across the Blue OP “a-gain” by Ray – AOKANA: Four Rhythm Across the Blue ED “Knew day” by [K]NoW_NAME – Grimgar of Fantasy and Ash OP “Harvest” by [K]NoW_NAME – Grimgar of Fantasy and Ash ED “Your Voice Becomes a Map” by Saori Hayami – Snow White With The Red Hair 2 OP “Page~The Story I Weave With You” by Saori Hayami – Snow White WTRH 2 ED “Naked Dive” by SCREEN mode – Myriad Colors Phantom World OP “If You Knit a Rainbow” by fhana – HARUCHIKA OP “Imaginary Triangle” by ChouCho – HARUCHIKA ED “That was like a small light” by Sayuri – ERASED ED “I Won’t Love You If You Don’t Say It Straight” by Sayuri Ishikawa – Lupin 3rd Pt4 ED “Kazekiri” by Nagi Yanagi – Norn9: Norn + Nonette OP “Zero to Kei” by Kaori Oda – Norn9: Norn + Nonette ED “One Me Two Hearts” by Hitorie – DIVINE GATE OP “GATE II ~Surpass the World~” by Kishida Kyoudan and The Akeboshi Rockets – GATE II “Kawa, Taredoki” by Kana Shibue – Showa Genroku Rakugo Shiju ED “STORY” by Kensho Ono – Luck and Logic OP “Genesis” by STEREO DIVE FOUNDATION – Dimension W OP “Contrast” by Fo’xTails – Dimension W ED “Beat your Heart” by Konomi Suzuki – BBK/BRNK OP “Anger/Anger” by Myth and Roid – BBK/BRNK ED “Starry Sky Rendezvous” by Sekko Boys – Sekko Boys OP

As with every new anime season, its arrival brings to us a horde of new beats to listen to and enjoy. Along with that, is the Otaku Spirit Radio podcast episode where we highlight the best of these tunes. So turn up your speakers and enjoy! The amazingly high paced and trancing Stero Dive Foundation, the soothing Aoi Tada, smiles of Ray, heavy rocks of OxT, dempa of Gakuen Seikatsu-bu, soothing vocals of kalafina, and so many other amazing artists to throw your worries away with.

Diese Arbeit konnte eine inhibitorische Kontrolle der HPA-Achse unter basalen und Streß-induzierten Bedingungen durch intrazerebrales OXT zeigen, die zumindest anteilig über Neuronen des hypothalamischen PVN vermittelt wird. Die neurohypophysäre Freisetzung von OXT und das angstbezogene Verhalten scheinen hingegen von zentralem OXT unabhängig zu sein. Eine ähnliche Funktion bei der Regulation der HPA-Achse und des Angstverhaltens wurde bereits für AVP beschrieben. Also sind beide Neuropeptide, wenn sie zentral freigesetzt werden, an der Modulation der Streßreaktion beteiligt und diese Funktion ist dissoziiert von ihrer peripheren Freisetzung und Wirkung. Während der peripartalen Periode, die Trächtigkeit, Geburt und Laktation einschließt, sind morphologische und funktionelle Veränderungen von OXT-Neuronen bekannt. So erfolgt eine spezifische Aktivierung des Systems durch Reproduktions-bezogene Stimuli, während, wie auch hier bestätigt werden konnte, die Streßreaktivität der selben Neuronen inhibiert wird. Ähnlich ist die Streßreaktivität der HPA-Achse während Trächtigkeit und Laktation reduziert. So wurde in dieser Arbeit erstmalig eine Suppression der ACTH- und Corticosteron-Freisetzung auch während des Geburtsvorganges beschrieben. Die Untersuchung der Wechselwirkungen des zentralen OXT-Systems und der hypophysären Sekretion nach Streß-Exposition zeigte deutlich veränderte Effekte intrazerebral freigesetzten OXTs während der peripartalen Periode. Bezüglich der HPA-Achse konnte ein Nachlassen der tonischen Inhibition durch zentrales OXT beobachtet werden, während nun die Streßinduzierte neurohypophysäre Freisetzung von OXT sowie das angstbezogene Verhalten auf der plus-maze dadurch kontrolliert wurden. Die während der peripartalen Periode verminderte Streßreaktivität der HPA-Achse wird also, entgegen der primären Hypothese, offensichtlich nicht durch das aktivierte OXT-System vermittelt. Da sowohl die HPA-Achse als auch das OXT-System z. T. durch endogene Opiate beeinflußt werden, lag die Vermutung nahe, daß Opiat-Rezeptoren die Reproduktionsbezogenen Modifikationen der neuroendokrinen Streßreaktivität vermitteln. Diese Hypothese konnte in der Tat bestätigt werden. Die Stimulation der HPA-Achse virginer Weibchen durch endogene Opiate verschwand gegen Ende der Trächtigkeit und resultierte in einer effektiven Inhibition der HPA-Achse während der Geburt. Während die neurohypophysäre OXTFreisetzung bei virginen Tieren nicht durch Opiate beeinflußt wurde, entwickelte sich während der späten Trächtigkeit und während der Geburt einen effektive Kontrolle durch endogene Opiate. Die zentrale Freisetzung von OXT im PVN unterlag keinen merklichen Reproduktions-bedingten Modifikationen, wurde jedoch unabhängig von der peripheren Sekretion durch endogene Opiate beeinflußt. Auch hier kehrte sich die bei virginen Tieren deutliche Stimulation der OXT-Freisetzung im PVN in eine effektive Inhibition während der Trächtigkeit um. Diese Modifikationen in der Wirkung von Opiat-Rezeptoren scheinen sowohl lokal als auch funktionell eng begrenzt zu sein, da auch bei trächtigen Tieren veränderte Opiat-Wirkungen weder hinsichtlich der OXT-Freisetzung im SON noch der verhaltensbiologischen Streßbewältigung beobachtet werden konnten. Die primäre Intention der Arbeit, die funktionelle Relevanz zentralen OXTs bei der Expression von Angstverhalten und der Streßreaktivität der HPA-Achse zu klären, konnte mittels des Tiermodells der peripartalen Periode nicht weiter verfolgt werden. Erstens verschwand die bei männlichen und virginen Tieren beschriebene Kontrolle der HPA-Achse durch endogenes OXT während Trächtigkeit und Laktation. Zweitens deutet die nur bei trächtigen und laktierenden Tieren beobachtete anxiolytische Wirkung zentralen OXTs eine während der peripartalen Periode von neuroendokrinen Parametern dissoziierte Regulation verhaltensbiologischer Streßreaktionen an. Drittens erlauben die vielfältigen systemischen Modifikationen während der Reproduktion, einschließlich schwankender Konzentrationen von Sexualhormonen und der Veränderungen des endogenen Opiat-Systems, keine unbeeinflußte Untersuchung einzelner Streßhormon-Systeme. Deshalb war es sinnvoller, sich dem Tiermodell der HAB/LAB-Ratten zuzuwenden, das pathophysiologische Veränderungen der Emotionalität vorweist. Hier konnte die Assoziation von verhaltensbiologischen und neuroendokrinen Streßreaktionen selektiv untersucht werden. Zunächst wurden die HAB/LAB-Tiere einer verhaltensbiologischen Charakterisierung unterzogen, die stabile Linien-spezifische Verhaltens-Unterschiede unter allen untersuchten Bedingungen bestätigen konnte. Die neuroendokrine Charakterisierung der Zuchttiere zeigte bei HAB-Männchen eine Assoziation der extremen Ängstlichkeit mit einer erhöhten Reaktivität der HPA-Achse auf einen emotionalen Stressor (open-arm). Jedoch konnte weder im Blut noch im PVN unter basalen oder stimulierten Konditionen eine differentielle Freisetzung von OXT gezeigt werden. Mit diesem Ergebnis konnte kein kausaler Zusammenhang des Linien-spezifisch unterschiedlichen Angstverhaltens und der unterschiedlichen Reaktivität der HPA-Achse auf Streß mit der zentralen oder peripheren OXT-Freisetzung festgestellt werden. Da jedoch eine erhöhte basale und Schwimmstreßinduzierte Freisetzung von AVP im PVN männlicher HABs ermittelt werden konnte, wurden weitere Untersuchungen bezüglich dieses Neuropetides unternommen. So konnte bei männlichen HAB-Ratten mittels in situ Hybridisierung eine signifikant höhere basale Expression von AVP-mRNA in magnozellulären Neuronen des PVN nachgewiesen werden. Die periphere AVP-Sekretion unter basalen und open-arm-stimulierten Konditionen zeigte weder Unterschiede zwischen HABs und LABs noch eine effektive Stimulation durch Streß- Exposition, so daß die erhöhte AVP-mRNA-Expression bei HABs die Grundlage für die gesteigerte zentrale Freisetzung bilden dürfte. Diese Ergebnisse signalisieren eine Interaktion von extremem Angstverhalten, erhöhter Streßreaktivität der HPA-Achse und gesteigerter Freisetzung von AVP im PVN bei HAB-Ratten. Unterstützt wurde diese Theorie auch durch die Normalisierung des pathologischen Dex/CRH-Tests bei HABs durch Applikation eines AVP-Antagonisten. Trotz dieser überzeugenden Hinweise sollten noch weitere Untersuchungen folgen, die durch Ausschalten der hypothalamischen AVP-Freisetzung mittels Antagonisten oder antisense targeting die Kausalität dieser Zusammenhänge klären könnten. Neben der gesteigerten Reaktivität der HPA-Achse zeigten HAB-Ratten eine höhere periphere Freisetzung von Prolaktin unter basalen und Streß-stimulierten Bedingungen. Da dieses Ergebnis u. a. eine differentielle Aktivierung des zentralen Dopaminund /oder Serotonin-Systems andeutet, sollten auch in dieser Hinsicht weitere Untersuchungen erfolgen, da auch diese Neurotransmitter mittelbaren oder unmittelbaren Einfluß auf die HPA-Achse ausüben können und zudem bei der Entstehung von Angst- /Depressions-Erkrankungen beteiligt zu sein scheinen. Wie durch die cross-mating-Studie bestätigt, liegt bei HAB/LAB-Ratten eine eindeutige genetische Determination des zwischen den Linien differierenden angstbezogenen Verhaltens vor. Die Untersuchung perinataler Faktoren ergab zwar eine mögliche hormonelle Beeinflussung von HAB-Föten durch eine chronisch erhöhte Plasmakonzentration mütterlichen Corticosterons, jedoch dürfte diese allenfalls einen modulierenden Einfluß auf die fötale Entwicklung haben. So bietet dieses Tiermodell einzigartige Möglichkeiten nicht nur zum Studium der neuroendokrinen Grundlagen psychopathologischer Emotionalität sondern auch der genetischen Korrelate. Solche genetischen Studien, z. B. die Suche nach "quantitative trait loci" oder genetische Assoziationsstudien bei den HAB/LAB-Ratten werden möglicherweise einen großen Beitrag zum Verständnis der Entstehung psychiatrischer Erkrankungen beim Menschen leisten und zu einer spezifischeren pharmakologischen Therapie führen können.