Podcasts about pcrs

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Best podcasts about pcrs

Latest podcast episodes about pcrs

Tick Boot Camp
Episode 539: Geoff Dow on Babesiosis: Malaria Parallels, Tafenoquine (Arakoda), and New Clinical Trials for Chronic Tick-Borne Disease

Tick Boot Camp

Play Episode Listen Later Oct 11, 2025 80:02


Dr. Geoff Dow, CEO of 60 Degrees Pharmaceuticals and former malaria drug developer at Walter Reed, joins the Tick Boot Camp Podcast to unpack the science and strategy behind treating babesiosis. Drawing parallels to malaria, Dow explains why tafenoquine (brand: Arakoda), FDA-approved for malaria prevention, is being studied for Babesia, how coinfections (Borrelia, Bartonella) complicate care, and why chronic illness needs a different clinical approach. He previews an upcoming Mount Sinai trial for chronic babesiosis focused on fatigue outcomes and discusses real-world diagnostics using FDA-approved blood donor screening plus PCRs from Galaxy Diagnostics and Mayo Clinic. The conversation also touches on prophylaxis concepts, immune dysregulation, and building a clearer path from anecdote to evidence for the tick-borne disease community. Guest Geoff Dow, BSc, MBA, PhD CEO & Board Member, 60 Degrees Pharmaceuticals Background: Biotechnology (Perth, Australia), PhD in malaria drug discovery, decade at Walter Reed Army Institute of Research, MBA in the U.S. Leads clinical programs exploring tafenoquine for babesiosis. Key Topics & Takeaways Malaria ↔ Babesiosis Parallels: Both are red-blood-cell parasites; acute symptoms driven by red cell destruction. Similar drug targets justify testing some anti-malarials against Babesia. Why Tafenoquine (Arakoda): An 8-aminoquinoline that induces oxidative stress in RBCs; distinct mechanism from atovaquone + azithromycin combo (current standard for acute babesiosis), potentially useful for resistance management. Chronic vs. Acute Disease: Acute babesiosis in immunocompetent patients often responds to standard care; chronic illness remains under-defined and underserved. Coinfections Are Common: Many chronically ill patients present with Borrelia, Bartonella, and Babesia together; diagnostics and treatment need to acknowledge polymicrobial reality. Upcoming Clinical Trial (Mount Sinai): Population: Chronic babesiosis with disabling fatigue, plus Babesia symptoms (e.g., air hunger, anemia) and lab evidence in the last 12 months. Regimen: 4-day loading dose then 200 mg weekly of tafenoquine for 3 months. Outcomes: Patient-reported fatigue (quality-of-life) + monthly molecular testing (FDA blood donor test, Galaxy Diagnostics PCR, Mayo Clinic PCR) during treatment and 3 months post-therapy. Goals: Demonstrate symptom improvement, assess eradication signals, and validate accessible diagnostics against an FDA-accepted assay. Prophylaxis & Post-Exposure Ideas: Animal data suggest short-course tafenoquine can eradicate early Babesia; human prophylaxis trials face feasibility and regulatory hurdles. Diagnostics Gap: Need for standardized, sensitive tools to define chronic babesiosis and track response. This trial also serves as a real-world diagnostic comparison. Immune Dysregulation & IACI: Overlap among long COVID, ME/CFS, post-treatment Lyme—shared theme of immune dysregulation with possible persistent antigen stimulation. Safety Notes: G6PD deficiency is relevant to 8-aminoquinolines; established safety database exists for malaria prevention dosing—critical as studies expand to babesiosis. Notable Quotes “You've got to put some lines in the sand—run the trial, collect data, and move the field forward.” “The best we can do for chronic disease starts with defining it—and validating the diagnostics we use to track it.” “8-aminoquinolines offer a different mechanism than current babesiosis standards—key for resistance and combinations.” Resources Mentioned Arakoda (tafenoquine): FDA-approved for malaria prevention; under study for babesiosis. Diagnostics: FDA-approved Babesia blood donor screen; Galaxy Diagnostics PCR; Mayo Clinic PCR. Organizations & Events: ILADS, Global Lyme Alliance, tick-borne disease conferences. Research Partners: Mount Sinai (NYC), Tulane University (Bartonella/Borrelia collaboration). Who Should Listen Patients with chronic Lyme or chronic babesiosis symptoms (fatigue, air hunger, anemia) Clinicians seeking updates on Babesia treatment research and diagnostics Caregivers and advocates tracking IACI and immune dysregulation science Researchers exploring antimalarial repurposing for tick-borne diseases Call to Action Subscribe to Tick Boot Camp and share this episode with someone navigating chronic tick-borne illness.

Fertility and Sterility On Air
Fertility and Sterility On Air - Live from the PCRS 2025 Annual Meeting

Fertility and Sterility On Air

Play Episode Listen Later Jun 22, 2025 50:47


Fertility & Sterility on Air is at the Pacific Coast Reproductive Society 2025 Annual Meeting in Indian Wells, CA! In this episode, our hosts Kate Devine and Micah Hill talk with: PCRS leadership Alexander Quaas and Jason Franasiak discussing this and future conferences (0:41), Shannon Rainsford about Protamine 2 deficiency (9:54), Andria Besser about mosaic and segmental PGT-A results (16:15), Emily Patterson about comprehensive carrier screening (28:35), Esther Chung about a low-cost progestin protocol for oocyte cryopreservation (32:23) and Howard Li discussing the feasibility of microwave drying for long-term storage of human oocytes at non-freezing temperatures (41:28). View Fertility and Sterility at https://www.fertstert.org/  

The Weekly Bioanalysis - The Official Podcast of KCAS
The Rapid Evolution of PCR Assays with Special Guest, Carrie Vyhlidal

The Weekly Bioanalysis - The Official Podcast of KCAS

Play Episode Listen Later Aug 28, 2024 82:46


Our hosts, Dom and John, are excited to welcome special guest, Carrie Vyhlidal, to discuss the topic of the 80th episode of “The Weekly Bioanalysis” podcast – The Rapid Evolution of PCR Assays. PCR (or Polymerase Chain Reaction) is like a copying machine for DNA. Scientists have found ways to measure the copies being made throughout the reactions, which is where they get their real-time, quantitative PCR (or qPCR). Carrie does a wonderful job of explaining not only why these advancements in the study of PCRs are so amazing – but also why they play (and will continue to play) such an important part in bioanalysis.“The Weekly Bioanalysis” is a podcast dedicated to discussing bioanalytical news, tools and services related to the pharmaceutical, biopharmaceutical and biomarker industries. Every month, KCAS Bio will bring you another 60 minutes (or so) of friendly banter between our two finest Senior Scientific Advisors as they chat over coffee and discuss what they've learned about the bioanalytical world the past couple of weeks. “The Weekly Bioanalysis” is brought to you by KCAS Bio.KCAS Bio is a progressive growing contract research organization of well over 250 talented and dedicated individuals with growing operations in Kansas City, Doylestown, PA, and Lyon, France, where we are committed to serving our clients and improving health worldwide. Our experienced scientists provide stand-alone bioanalytical services to the pharmaceutical, biopharmaceutical, animal health and medical device industries.

Chasin' The Racin'
#221 Facebook messenger to moto2 [EITAN BUTBUL]

Chasin' The Racin'

Play Episode Listen Later Aug 25, 2024 72:02


This week on Chasin' the Racin' podcast, Dom Herbertson & Josh Corner are joined in the trailer by the Moto2 American Racing team owner Eitan Butbul. He tells us how he went from a fan of the racing back in Israel to owning a team on the world stage, the costs of doing so, the challenges that come with it and of course we touch on the deal with Skinner's time with the team & how that came to an end. Enjoy - CTR x   Powered by OMG Racing  Supported by JCT Truck & Trailer Rental and Bennetts  Sponsor of the ep: PCRS - the Irish official Öhlins sales and services centre. They would like to use this episode to let everyone know there is going to be fundraiser for Anthony O'Carroll, who was involved in an incident at the Southern 100 this year as he is still in hospital over in Liverpool and his parents have been there with him since the accident. The fundraising event is happening in Ballyduff in Co Kerry Ireland on the weekend of September 13th-15th so get yourselves there if you're local and help raise some funds for the family in this difficult time.   If you're interested in sponsoring an episode of the podcast, please don't hesitate to get in touch via email to chasintheracin@outlook.com   ------------   If you would like to get a signed copy of Alan Carter's book please follow the following link below. It is currently UK shipping only but we are working away behind the scenes for it to be available worldwide - keep up to date on our socials to see when this becomes active!       Shop CTR merchandise & AC book: https://chasintheracin.myshopify.com     CTR Patreon Page: https://patreon.com/MotorbikePod?utm_...     -------------     SOCIALS:   Instagram: @chasintheracinpod   Facebook: Chasin' The Racin' Podcast   X: @motorbikepod

Santé-vous mieux!
Épisode 51 : Ce que votre bouche révèle sur votre santé métabolique avec Dre Roxane Katiya, dentiste

Santé-vous mieux!

Play Episode Listen Later Aug 13, 2024 31:06


Dans l'épisode d'aujourd'hui, nous parlerons du lien entre la santé buccale et la santé métabolique. Il s'agit de notre premier épisode d'une série d'épisodes qui seront basés sur les conférences du Sommet virtuel de la santé métabolique 2024. Ces conférences sont encore disponibles à l'achat sur sommetmetabolique.com. Dre Roxane Katiya, qui est dentiste généraliste en pratique privée à Saint-Bruno-de-Montarville. Sa pratique englobe l'implantologie, la réhabilitation complète, l'apnée du sommeil et le ronflement. Dre Katiya est diplômée depuis 2006 de l'Université de Montréal et depuis 2007 de l'Université de Rochester, à New York.Sujets abordés :impact de la santé buccale sur la santé métaboliqueimportance du contrôle du diabète et hygiène dentairel'associations entre les bactéries orales et les maladies coronariennes, certains cancers, l'arthrite rhumatoïde et les accouchements prématurésmicrobiote buccal, une entité moins bien connuelien entre la parodontite et de l'impact des rince-bouches sur les maladies chroniqueseffets nocifs de la chlorhexidine sur le microbiome oralsyndrome de la bouche qui brûle importance de l'apnée et du ronflement en dentisteriecontroverse sur l'utilisation du fluor en dentisterieComment la santé buccale affecte-t-elle la santé globale métabolique?Les maladies parodontales peuvent vraiment affecter le corps, en particulier le cœur Les infections respiratoires L'ostéoporosePerte de dents  Le diabète entretient une relation bidirectionnelle avec la maladie parodontale Il y a aussi un lien entre la maladie parodontale et la polyarthrite rhumatoïde Les rince-bouche La Dre Katiya suggère : Biotène ou Terabreath et les pastilles Denta Mouth.  Le syndrome de la bouche qui brûle ou “burning mouth syndrome” en anglais. L'apnée du sommeil et le ronflement La Dre Katiya suggère d'utiliser l'application SnowLab qui permet aux individus de dépister s'ils ronflent. Le fluor, est-ce nocif pour la santé? C'est maintenant l'heure de l'astuce de la semaine : il faut écouter l'épisode pour la connaître!Messages clés : Premier message clé : la santé de la bouche a beaucoup plus d'impacts sur la santé métabolique qu'on pourrait le soupçonnerIl y a une association entre les mauvaises bactéries de la bouche, le tartre et l'inflammation, et les maladies cardiovasculaires, certains cancers dont le cancer du côlon, la polyarthrite rhumatoïde, les accouchements prématurés et les bébés naissants de petit poids, le diabète, la résistance à l'insuline, les maladies intestinales inflammatoires, les infections respiratoires et même la maladie d'Alzheimer. Il y a même un lien bidirectionnel entre le diabète et l'hygiène dentaire Tout comme nous avons un microbiote intestinal qui est de plus en plus reconnu comme étant notre 2e cerveau, nous avons aussi un microbiote oral et si celui-ci est en déséquilibre, avec trop de mauvaises bactéries par rapport aux bonnes, si on est en dysbiose, eh bien ça peut entraîner toutes sortes de problèmes de santé dans le reste du corps. Les rinces-bouche affectent négativement le microbiote oral. Le syndrome de la bouche qui brûle est un problème qui est plus fréquent chez les femmes en périménopause ou en ménopause. Le dentiste peut aider. L'apnée du sommeil et les ronflements peuvent relever de la dentisterie. L'utilisation du fluor dans l'eau ou dans les pâtes à dents pour prévenir les caries est un sujet controverséPour commander un test en ligne et le faire livrer chez vous : Test de sommeil à domicile pour dépistage d'apnée du sommeil (PCRS) - (centreaxis.ca)Pour obtenir un rendez-vous pour avoir une requête de dépistage d'apnée du sommeil : Rendez-vous - Traitement de l'apnée du sommeil - Somnos (cliniques-somnos.com) (exemple de clinique, il y en a d'autres au Québec qui offrent ce service)

Fertility and Sterility On Air
Fertility and Sterility On Air - Seminal Article: Ernest Ng, and Zhi Chen

Fertility and Sterility On Air

Play Episode Listen Later Jun 30, 2024 17:55


Fertility & Sterility on Air brings you a deep dive into the June issue Seminal Contribution: a randomized controlled trial studying the use of progestins for ovulation supression in predicted high responders. With Micah Hill, Ernest Ng, and Zhi Chen. Read the article: https://www.fertstert.org/article/S0015-0282(24)00030-X/abstract View Fertility and Sterility at https://www.fertstert.org/  

Because Jitsu Podcast
#575: The 411 on PCRs

Because Jitsu Podcast

Play Episode Listen Later Jun 10, 2024 69:29


Some old news is making the new news recently and is getting shared around the alternative circles. That PCR tests were 97% false positive! What does that mean and what did that change? ----- Get into Gold & Silver and out of the fiat trap below: https://7kmetals.com/drewweatherhead/ Get Tickets to the 2024 Parental Rights Tour with Dr. James Lindsay in Alberta: https://brushfire.com/anv Join the chat LIVE on Rumble for future Social Disorder Podcasts! https://rumble.com/user/SocialDisorderPodcast Get your edition of Layers of Truth at the links below: Audiobook: https://www.audible.ca/pd/B0D1VV75CM?source_code=ASSOR150021921000V Hardcover: https://shorturl.at/quLO7 Paperback: https://amzn.to/3U97tz5 Support the show one time or become an OFFICIAL Pattern Enjoyer by pledging to donate monthly below: https://www.buymeacoffee.com/drewweather Tell me what you thought of the show! Text me at: (587)206-7006 Get you copy of "Consciousness Reality & Purpose" on Amazon.com TODAY: https://www.amazon.com/dp/B0BS5FWLBK Subscribe to the Social Disorder Substack: https://thesocialdisorder.substack.com/ This episode is made possible by: DrewJitsu Online Jiu-Jitsu Coaching Sign up to get 2 week FREE to a library of over 750+ Brazilian Jiu-Jitsu Technique videos taught by your host - Drew Weatherhead! Hit the link below to get started today! https://drewjitsuonline.com/orders/customer_info?o=43849

Fertility and Sterility On Air
Fertility and Sterility On Air - Live from PCRS 2024

Fertility and Sterility On Air

Play Episode Listen Later Apr 7, 2024 34:05


Fertility & Sterility on Air brings you the highlights from the 2024 Annual Meeting of the Pacific Coast Reproductive Society, with interviews of presenters at PCRS 2024 in Indian Wells, CA! We had a chat with the winners of the PCRS Awards, as well as with authors of other very interesting studies evaluating a wide range of subjects in the field of reproductive medicine: determining the ploidy of abnormally fertilized embryos, predicting whether sperm will be obtained surgically in non-obstructive azoospermia, de novo oocyte creation from stem cells, and trialing needle-free IVF. We also take a deeper dive into the meeting with the president and incoming president of PCRS: Tamara Tobias and Alexander Quaas. View Fertility and Sterility at https://www.fertstert.org/

Inside EMS
Chief Gary Ludwig on fixing medics' terrible charting

Inside EMS

Play Episode Listen Later Oct 5, 2023 23:39


This episode of Inside EMS is brought to you by Lexipol, the experts in policy, training, wellness support and grants assistance for first responders and government leaders. To learn more, visit lexipol.com. In this episode of Inside EMS, cohosts Chris Cebollero and Kelly Grayson welcome Chief Gary Ludwig to the podcast. The group discuss imparting knowledge to new medics and Ludwig's latest book, “385 Things Veteran EMTs and Paramedics Can Teach You: Emergency Medical Technician and Paramedic Tips and Tricks of the Trade.” The book contains information on patient assessment, managing airways, starting IVs, penetrating trauma, crimes scenes and more. Chief Ludwig shares his experience with terrible PCRs, and why we should be teaching medics to write reports like our law enforcement partners. He shares tips like: Why you should always stay in the left lane How to avoid tipping stretchers Why to avoid abbreviations in PCRs For a signed copy, visit www.garyludwigbooks.com. About our guest  Gary Ludwig is a well-known author, educator, speaker, and consultant who has served in three fire departments over his career. His fire, EMS, rescue, 911 and emergency management career spans a total of 46 years, including 35 years in two metropolitan cities, St. Louis and Memphis. He has been a paramedic for over 44 years. He served as the president of the International Association of Fire Chiefs (IAFC) during the 2019-20 term, and was selected as the International Career Fire Chief of the Year in 2022. He has a master's degree in business and management.  He has written over 500 articles for professional fire and EMS publications and is the author of four books.  He has also been invited to speak at over 400 professional EMS or fire conferences or seminars. He has won numerous awards including the International Career Fire Chief of the Year in 2022, the James O. Page EMS Leadership Award in 2014 and the IAFC EMS Section's James O Page Achievement Award in 2018. He has managed two award-winning metropolitan EMS systems (Memphis and St. Louis) and was fire chief of an ISO Class 1 fire department (Champaign).  In 2022, he was appointed by FEMA Administrator Deanne Criswell to the National Advisory Council for FEMA.

ADC podcast
Balance in (almost) everything

ADC podcast

Play Episode Listen Later Sep 7, 2023 11:41


Back to the cut and thrust of clinical neonatology for the September 2023 Archimedes, where we visit the challenge of sugar-free babies again. How do you move forward with uncertainty about the adverse effects of medicines but significant problems with the adverse effects of disease processes? [doi 10.1136/archdischild-2023-325726]   We also flicker our minds back to the Olden Days, when analysers were simpler and viral PCRs were Special And Rare. And where Jones criteria were more in evidence than circulating IL23 levels. We ask - how does time change things? [doi 10.1136/archdischild-2023-326113]   We would love for you to be involved in Archi [adc.bmj.com/pages/authors/#archimedes] - just ask the questions that your patients are offering you - and tell us how you're fidning the podcast offerings.   Please listen to our regular podcasts and subscribe in Apple Podcasts, Google Podcasts, Stitcher and Spotify to get episodes automatically downloaded to your phone and computer. And if you enjoy the podcast, please leave us a review at https://podcasts.apple.com/gb/podcast/adc-podcast/id333278832

EMS One-Stop
PW&W's Stark and Johnson provide legal insight into PCRs

EMS One-Stop

Play Episode Listen Later May 30, 2023 45:25


This episode of EMS One-Stop With Rob Lawrence is brought to you by Lexipol, the experts in policy, training, wellness support and grants assistance for first responders and government leaders. To learn more, visit lexipol.com. Page, Wolfberg & Wirth was asked by the National EMS Information System (NEMSIS) Technical Assistance Center (TAC) to research frequently asked questions related to data in EMS patient care reports. PW&W analyzed these questions under applicable laws and guidance, and developed general answers and best practices contained in the new publication, “Patient Care Report Data QuickGuide - FAQs on owning, amending, retaining and sharing patient care report data.” In this week's EMS One-Stop, available in both video and audio versions, Host Rob Lawrence speaks with the PW&W authors of the project, Ryan Stark, managing partner, and Steve Johnson, director of reimbursement consulting. They discuss the guide, why it's needed, and the major FAQs and misconceptions about PCRs. The guide is broken down into four key areas of FAQs: PCRs' legal status Amending PCRs PCR retention Transferring PCR data Top quotes from this episode “I would much rather defend an organization who regularly goes through a quality assurance process, whereby they make the provider and hold them responsible for the accuracy and completeness of the record.” — Ryan Stark “Others may say, we see a lot of amendments to your records. The answer is ‘yes, that's because we care about getting it right' – that's the mantra of our organization.” — Ryan Stark “One of the things behind the importance of documentation is that it doesn't live in a vacuum. We are in a day and age where it's going to follow the patient for their lifetime, so you may have a rehab facility that wants to consult the medical record to determine the mechanism of injury or how the injury occurred and the only person [that knows that] is the EMS practitioner.” — Ryan Stark “Long gone are the days where we can give you a quick ticket, passing along the information to the receiving facility. Now we are marrying up records, electronic health exchanges and other mechanisms and the genesis of all this starts with the original call.” — Steve Johnson “Everyone should sign the patient care report. Why? Because everyone was a function of providing that particular service and we get a lot of pushback and they say ‘well now I'm legally responsible for everything that happened,' and that's not what the law says. The law says, for what you did, you are responsible for what you did and what you didn't do when you had a legal duty to do something or withhold doing something because it was contraindicated. All that indicates is that yes, I reviewed it and to the best of my knowledge it's true and accurate.” — Ryan Stark “The law will impose liability where it lands. Just because you've signed that particular patient care report, doesn't mean you're responsible for all the interventions and everything that I outlined in there, it would be whoever performed or withheld those interventions that would be responsible within the scope of practice.” — Ryan Stark Episode contents 1:09 – Introductions 1:30 – PWW history 3:30 – Introducing the PCR Data QuickGuide 4:20 – The circle of life of a PCR  11:00 – NEMSIS data/research license and EMS by the numbers 13:20 – Who owns PCR data 15:50 – Signatures! And legal responsibility 17:40 – Accuracy of documentation to defend your actions 18:30 – Why does the driver have to sign? 20:00 – Amending PCRs: When and why 22:33 – Who do you tell if a record is amended? 24:30 – Can your state request you to amend your PCR? 27:30 – How long should we keep documents? 30:50 – When an agency closes down or merges 33:30 – Body-worn camera content 35:30 – Transferring paper records to digital 37:15 – Bi-directional data and HIE – responsibilities 40:00 – Final thoughts Additional resources The PCR Data QuickGuide is available now, and we encourage all EMS professionals to download their copies and gain a deeper understanding of PCR data best practices. To download the guide, please follow the link: About NEMSIS About Page, Wolfberg & Wirth About our guests Ryan Stark Ryan Stark is a managing partner with Page, Wolfberg & Wirth, and is the firm's resident “HIPAA guru.”  He counsels clients on labor relations, privacy, security, reimbursement and other compliance matters affecting the ambulance industry.  Ryan started in the healthcare field as a freshman in college, where he worked for a local hospital and a retail pharmacy.  After college, he decided to become a lawyer, hoping to guide healthcare providers through the demanding legal issues they face.  He has been with PW&W since 2007, fulfilling that ambition.   Ryan is passionate about educating EMS professionals and loves collaborating with providers and CEOs alike. He is a featured speaker in PW&W seminars and webinars, including the firm's signature abc360 Conference, where he hosts the abc360 Game Show. Always enthusiastic, Ryan has been invited to speak at many state and regional EMS conferences, as well as national industry events. He is also an adjunct professor at Creighton University in the school's Master of Science in Emergency Medical Services Program.  Ryan developed, and is the primary instructor for, the nation's first and only HIPAA certification for the ambulance industry – the Certified Ambulance Privacy Officer.  He also co-authored PWW's widely used Ambulance Service Guide to HIPAA Compliance.   Ryan volunteers with local community nonprofit organizations. He was also a big brother with the Big Brothers Big Sisters program for over a decade and keeps in touch with his “little.” Ryan also enjoys hiking, running, kayaking and traveling, and spending time with son Oliver.    Steve Johnson Steve began his career in the EMS industry in 1985, gaining valuable experience while serving as an EMT and later as director of a municipal ambulance service in Minnesota. As an ambulance service manager, Steve established his expertise in areas of operations, billing and administration.   Steve also has significant EMS educational experience. He established and served as training coordinator and lead instructor for a State Certified EMS Training Institution for EMTs and First Responders.   Steve served on both the Rules Work Group and the EMS Advisory Council to the Minnesota State Department of Health. He joined the staff of a large, national billing and software company, where he was a frequent lecturer at national events and software user group programs. For over 7 years, Steve served as director of a national ambulance billing service and was responsible for all aspects of managing this company, including reimbursement, compliance and other activities for ambulance services throughout the nation. Steve served as founding executive director of the National Academy of Ambulance Coding (NAAC), overseeing all activities of the Academy, including the Certified Ambulance Coder program, the nation's only coding certification program specifically for ambulance billers and coders.   As the director of reimbursement consulting with Page, Wolfberg & Wirth, Steve is involved in all facets of the firm's consulting practice. Steve works extensively on billing and reimbursement-related activities, performing billing audits and reviews, improving billing and collections processes, providing billing and coding training, conducting documentation training programs, and performing many other services for the firm's clients across the United States.   Steve is also a licensed private pilot, and enjoys an active role in his church. Rate and review the EMS One-Stop podcast Enjoying the show? Please take a moment to rate and review us on Apple Podcasts. Contact the EMS One-Stop team at editor@EMS1.com to share ideas, suggestions and feedback.

Inside Reproductive Health Podcast
171 When Millennials Run An REI Practice. What Young REIs Must Know About Arbitrage

Inside Reproductive Health Podcast

Play Episode Listen Later Mar 5, 2023 59:08


“Money is made when you buy, not when you sell.” Is the saying for real estate investors also true for fertility doctors, their work-life balance, and their control over quality of patient care? How does an entrepreneurial fertility specialist find the REI practice equivalent to the under-priced house in the up-and-coming neighborhood? The one with unbelievably beautiful bones that isn't too much of a fixer-upper, but is just at the inflection point where its market price is about to shoot up like a hockey stick? There aren't many. Few fertility practices have already transitioned their embryology and business leadership to the same generation as the fertility doctors that will take over. But there are a couple, and we found one. Christine DeLuca and Stephen Hutchison join Griffin this week to discuss what it looks like when millennials run an REI practice. Listen to hear: How younger docs find the best value in an REI practice. What Stephen and Christine's team is doing at PCRS, that independently owned fertility practices almost never do What changes Millenials are making in the fertility practice industry- embryo storage, cryo inventory, and more. What it looks like to work in a culture where you not only help to create babies but can bring your own baby to work. Arbitrage and younger docs PS: Watch what Stephen and Christine and their team can do. Can you do this at your practice?

NB Hot Topics Podcast
S4 E8: JOMT Interview with PCRS chair, Dr Katherine Hickman; pushing bad pills, eye drops for myopia, CVD risk prediction in cancer survivors

NB Hot Topics Podcast

Play Episode Listen Later Feb 17, 2023 29:19


Welcome to the Hot Topics podcast with Dr Neal Tucker.  In this episode, we speak to Dr Katherine Hickman, current chair of the Primary Care Respiratory Society, who answers our three Just One More Thing questions on what we need to know about from primary, secondary and future care with asthma. In new research, we discuss a paper on how pharmaceutical companies spend more money promoting less effective drugs, how atropine eye drops in children can delay myopia, and whether cancer risk prediction tools are accurate in cancer survivors with their inherently raised CVD risk. www.nbmedical.com/podcast ReferencesPrimary Care Respiratory Society - if you want to know more!JAMA Drug spending on low clinical benefit drugsJAMA Atropine eye drops in kids to delay or prevent myopiaLancet CVD risk prediction tool accuracy in cancer survivors

Astro arXiv | all categories
Period Change Rates of Large Magellanic Cloud Cepheids using MESA

Astro arXiv | all categories

Play Episode Listen Later Sep 22, 2022 0:50


Period Change Rates of Large Magellanic Cloud Cepheids using MESA by F. Espinoza-Arancibia et al. on Thursday 22 September Pulsating stars, such as Cepheids and RR Lyrae, offer us a window to measure and study changes due to stellar evolution. In this work, we study the former by calculating a set of evolutionary tracks of stars with an initial mass of 4 to 7 $M_odot$, varying the initial rotation rate and metallicity, using the stellar evolution code Modules for Experiments in Stellar Astrophysics (MESA). Using Radial Stellar Pulsations (RSP), a recently added functionality of MESA, we obtained theoretical instability strip (IS) edges and linear periods for the radial fundamental mode. Period-age, period-age-temperature, period-luminosity, and period-luminosity-temperature relationships were derived for three rotation rates and metallicities, showing a dependence on crossing number, position in the IS, rotation, and metallicity. We calculated period change rates (PCRs) based on the linear periods from RSP. We compared our models with literature results using the Geneva code, and found large differences, as expected due to the different implementations of rotation between codes. In addition, we compared our theoretical PCRs with those measured in our recent work for Large Magellanic Cloud Cepheids. We found good overall agreement, even though our models do not reach the short-period regime exhibited by the empirical data. Implementations of physical processes not yet included in our models, such as pulsation-driven mass loss, an improved treatment of convection that may lead to a better description of the instability strip edges, as well as consideration of a wider initial mass range, could all help improve the agreement with the observed PCRs. arXiv: http://arxiv.org/abs/http://arxiv.org/abs/2209.10609v1

The Mike Hosking Breakfast
Mark the Week: Now head down, bum up, let's get it done

The Mike Hosking Breakfast

Play Episode Listen Later Jul 14, 2022 2:23


At the end of each week, Mike Hosking takes you through the big ticket items and lets you know what he makes of it all. Planes and Chaos at Airports: 4/10"Because although not everything is in your control, a lot is. And enough, I suspect, to overall do better than they have.Heathrow asked airlines to stop over-selling flights. That's called greed." Covid Red Light: 6/10"Because we aren't going into it despite all the whispers.But if the school holidays don't work, stand by." RATs being Made Free: 6/10"Oh, the irony.The government that couldn't commandeer enough of them, the government that insisted PCRs were all we needed, and yet look at us now." ACT: 8/10"25 years in Parliament. That's worth celebrating." The Government's Mega Polytech Merger: 3/10"Can someone call us if they see the bloke who is supposed to be running the place?And can he tell us why they are in the hole to the extent they are?" The Government's Gang Plan: 6/10"Because it shows if you have a couple of ministers awake, you can actually do something.As opposed to pretending nothing is happening." Andrew Little: 2/10"Because it shows if you have a minister awake you can actually do something instead of pretending it's not a crisis." Number of People Leaving New Zealand: 6/10"It's not as bad as some had imagined.Yes, we are losing more people than are arriving but it wasn't a stampede." Christchurch Stadium: 8/10 "Thank God for that. Would have been a higher score if they hadn't mucked around for so long. That's the lesson here.Now head down, bum up, let's get it done." The All Blacks: 6/10."Because a loss is not the disaster or the sacking offence too many have made it out to be." LISTEN ABOVE FOR MIKE HOSKING'S FULL WEEK IN REVIEWSee omnystudio.com/listener for privacy information.

Exhale With Vitalograph
Episode # 26 Carol Stonham United Kingdom Respiratory Expert

Exhale With Vitalograph

Play Episode Listen Later Jul 6, 2022 22:38


Featured Guest: Carol Stonham. Following 26 years working in general practice Carol now works at Gloucestershire CCG on the Respiratory Clinical Programme Group and runs a locality-based asthma FeNO service. Carol has also been appointed as a co-clinical lead of the NHSE South West Respiratory Network. Carol is current Executive Chair of PCRS – the first non-doctor and first female to take the chair. She is also a director of the UK Lung Cancer Coalition, and a board member of the UK Inhaler Group and National Asthma and COPD Audit as well as sitting on the NHS Long Term Plan Respiratory Delivery Board.  She also co-chairs the Lung Health Task Force early and accurate diagnosis group and is a member of the NHS Long Term Plan Breathlessness Diagnosis group. Carol received Queen's Nurse award in 2007 and in 2016 was awarded an MBE in the Queen's New Year Honours list for Services to Nursing and Healthcare.

Conocimientos Musicales
Los tempos que corren, semana 32

Conocimientos Musicales

Play Episode Listen Later Jun 16, 2022 33:29


Un jueves más, la sección más impredecible de Conocimientos Musicales nos trae un programa lleno de juegos y sorpresas varias. La primera de ellas es la aparición, por última vez esta temporada, de Guillermo Gómez, que nos vuelve a acompañar para jugar a algunas PCRs (especial música de cine) y para ejercer de juez en nuestro particular Mundial. Antes, sin embargo, la pregunta de Pau nos lleva a reflexionar sobre el trabajo individual y colectivo necesario en las orquestas para que el resultado musical sea bueno, que demuestra las diferencias que hay entre los instrumentos de cuerda y los de viento en ese aspecto. Tras las PCR, la segunda semifinal del Mundial se abre paso con un apasionante Francia-Rusia, que se baten por un puesto en la final contra Alemania.

RNZ: Checkpoint
Covid tracer app creator keen to trial more accurate RAT in NZ

RNZ: Checkpoint

Play Episode Listen Later May 6, 2022 4:00


The man recognised as the brains behind the Covid tracer app, is trying to import and trial a new type of RAT test that could be as accurate as PCRs. New Zealand experts say it could provide cheap, quick, accurate testing with far fewer false negatives, but getting it across the border isn't proving straightforward. Katie Todd reports on a RAT roadblock.

The Big Story
927: What Led to Communal Tensions in Northwest Delhi's Jahangirpuri?

The Big Story

Play Episode Listen Later Apr 18, 2022 13:55


On Saturday, 16 April, violence broke out in Northwest Delhi's Jahangirpuri following a Shobha Yatra organised to mark Hanuman Jayanti. The Delhi Police have so far arrested 24 people and apprehended two juveniles in connection with communal clashes that broke out in North Delhi's Jahangirpuri after a religious Hindu procession allegedly attempted to hoist a flag on a mosque. According to the FIR filed by the police, arguments between two groups escalated after a man named Ansar came with a few people and started an argument with those participating in the yatra. The argument escalated and stone-pelting and sloganeering started from both sides. And as per purported videos of the yatra uploaded on social media and eyewitness accounts, several in the procession were carrying saffron flags, swords, pistols, and sticks. The police have also recovered three firearms and five swords from the accused persons. The Quint's reporter Fatima Khan spoke to several members of the procession and they claimed that they carried the swords for “fun”. This incident also comes days after the violence that erupted during the Ram Navami processions in several parts of the country. However, the twist in this incident is that there was a heavy deployment of police in the area where this scuffle took place. As per a report by The Indian Express, the Shobha Yatra also had police permission and around 50 police officials were deployed in Jahangirpuri along with PCRs, MVPs, and drones. Later, DCP Northwest Usha Rangani clarified that the procession took place without any permission. In today's episode, we take you through exactly what led to the violence in Jahangirpuri through eyewitness accounts and The Quint's ground reports on the same. We also speak to Somya Lakahni, Senior Editor at The Quint to know the latest on the investigation. Host and Producer: Himmat Shaligram Editor: Somya Lakhani Music: Big Bang Fuzz Listen to The Big Story podcast on: Apple: https://apple.co/2AYdLIl Saavn: http://bit.ly/2oix78C Google Podcasts: http://bit.ly/2ntMV7S Spotify: https://spoti.fi/2IyLAUQ Deezer: http://bit.ly/2Vrf5Ng Castbox: http://bit.ly/2VqZ9ur

The Real Expat Wives of Arabia
NO MORE PCRS!!!! Travel Has Returned Full Swing!!!

The Real Expat Wives of Arabia

Play Episode Listen Later Apr 5, 2022 11:56


Spring Break trip to Egypt and whats the going ons of international travel post pandemic. A sneak peek at my next guest.

Urbana Play 104.3 FM
#VueltaYMedia - Sketch Arbolito

Urbana Play 104.3 FM

Play Episode Listen Later Mar 5, 2022 4:10


Este arbolito vende dólares, PCRs, vacunas pero cuando llega la policía no lo admite... --- Send in a voice message: https://anchor.fm/urbanaplayfm/message

Early Edition with Kate Hawkesby
Kate Hawkesby: We're in Phase 3, it's now time to let it go

Early Edition with Kate Hawkesby

Play Episode Listen Later Feb 24, 2022 3:11


So we're into Phase 3 as of today – and not before time. Problem is, nobody knows what any of it means. I was out all day yesterday driving around Auckland and what I can tell you is that there are still snaking queues everywhere for PCR tests. Why? Why is no one getting the memo on that? Why are all these people still queuing for tests? Possibly because RATs, which we're supposed to be doing, are so hard to find.  One of my trips yesterday involved a covert side of the road operation like a drug mule, picking up RATs I'd managed to source – at no small expense I might add – from an anonymous source who was transferring them to me from their car boot wrapped in a rubbish bag. I kid you not. It's like prohibition days – only the prohibited substance is something that should be readily available to everybody, like it is all over the rest of the world.  Why RATs aren't in every Pharmacy up and down the country by now is beyond me.  But here at Hermit Central, we're still waiting to be told when we can have stuff, where, and how. God forbid we try to adult. I was tracking down RATs because I have a family member who was a contact, and their work required a negative test before they'd let them return. Unable to get a PCR, they managed to source a single RAT kit, did the test, sent the negative result to the employer, so far so good. Except for the fact the employer said they wanted a second test result done “just to be sure”.  Now here's where it gets iffy. Employers who are unilaterally making up the rules as they go for employees make things tricky. Where were they supposed to get another RAT from? They're like hens' teeth, still no access to PCRs, and let's not forget that under the new rules, being a contact doesn't even mean you have to isolate anymore anyway unless you're in the same household as the positive case. Was the employer going to supply the RAT? No, they weren't.  Many businesses are struggling to source them too, they're having to jump through hoops and if they're not critical, they're usually falling flat on their faces. So long story short, I went into mafia mode and sourced some RATs which even if you waterboard me I'm not going to tell you where from, and I was able to supply this family member with one so they could do another test. Desperate times call for desperate measures.  The infuriating thing is why is it all so desperate when we've had all this time to get ready for this? The problem's not just the RAT access and limited availability, but also the employers who're freestyling the rules, the people who're still confused about the new contact rules, those freaked out despite the Government relaxing the rules and still wanting to 'play it safe' - and all the people just making it up as they go along. Shambles? Yes, it is.  The Government's clearly given up on this, but we're so acclimatised to rules and fear, we seemingly can't let go. If I can just say one thing to you today it's this - it's time to let it go.

Código de barras
Código de barras | El palito a la nariz y el palo a la cartera

Código de barras

Play Episode Listen Later Jan 30, 2022 59:55


Ya llevamos casi dos años de pandemia… Y de negocio. En este programa de Código de Barras hablamos del mercado de las pruebas diagnósticas, un mercado en el que se ofertan PCRs con recargo de urgencia, servicio de test a domicilio o en hotel e incluso packs familiares con descuento para un servicio que es obligatorio para, por ejemplo, viajar a otros países. Vemos por qué no se regula y qué consecuencias tendría hacerlo.Hablamos también de cupones y promociones: ¿De verdad merecen la pena? ¿Qué trampas tienen las fórmulas que utilizan para enganchar al consumidor? Intentamos entender también por qué cada vez nos hacen menos efecto los antibióticos. Para terminar, Eugenio Ribón, presidente de la Asociación Derecho de Consumo, responde a vuestras consultas.

Esportes
Futebol: Camarões, Marrocos e Nigéria são destaques no início da Copa Africana de Nações

Esportes

Play Episode Listen Later Jan 16, 2022 8:46


As seleções de Camarões, Marrocos e da Nigéria foram as primeiras a garantir vaga para a próxima rodada da competição com uma rodada de antecipação. Neste domingo, jogos pelos grupos E e F encerram a segunda rodada da CAN, marcada por contrastes nos estádios, muitos deles com torcidas animadas e outros vazios, principalmente devido aos problemas ligados à Covid-19. Elcio Ramalho e Marco Martins, enviado da RFI aos Camarões Com duas vitórias nos dois primeiros jogos, camaroneses, marroquinos e e nigerianos já estão nas oitavas de final da CAN 2002. A equipe anfitriã do torneio venceu o Burkina Faso (2 a 1) na estreia e goleou a Etiópia (4 a 1) na segunda rodada, garantindo o primeiro lugar no grupo A e a classificação por antecipação.  Apesar dos resultados convincentes, o treinador português Antonio Conceição mostrou prudência sobre o desempenho da equipe de Camarões. "No plano defensivo estamos bem, e também no ataque, mas precisamos ainda melhorar para a próxima fase, que será mais difícil", disse o treinador após a goleada contra os etíopes.   Já a Nigéria também venceu os dois primeiros jogos – 1 a 0 contra o Egito e 3 a 1 sobre o Sudão – e lidera sozinha o grupo D.  No grupo C, a equipe do Marrocos também passou pelos dois primeiros adversários: 1 a 0 contra Gana e 2 a 0 contra Comores, e também já carimbou sua vaga para as oitavas da competição.  Seleções lusófonas Depois de um bom começo na primeira rodada, as duas equipes lusófonas, Guiné Bissau e Cabo Verde, perderam o segundo jogo, mas mesmo assim continuam vivas e com chances de classificação pois os quatro melhores terceiros colocados de seis grupos avançam.  Os caboverdianos estrearam com vitória de 1 a 0 sobre a Etiópia, mas perderam pelo mesmo placar para o Burkina Faso. A equipe tenta avançar para a próxima fase e para isso depende de um bom resultado contra os Camarões na última rodada da fase de grupos.  A Guiné Bissau tem um desafio ainda maior pois tem apenas um ponto na chave D, após o empate na estreia contra o Sudão. Na noite deste sábado pedeu para o Egito por 1 a 0 e precisa vencer a forte Nigéria na próxima quarta-feira (19) para brigar por uma vaga.   Contrastes nos estádios A CAN 2022 é disputada em seis estádios de cinco cidades dos Camarões, país da costa ocidental da África. Nos dois estádios em Yaoundé e em outros onde jogam seleções de países vizinhos como Nigéria e Senegal, a ocupação parcial das arquibancadas é garantida, com a presença de torcedores entusiasmados e barulhentos, vibrando ao som das vuvuzelas. No entanto, nas partidas de seleções distantes dos Camarões, como Sudão e Etiópia, por exemplo, as arquibancadas ficam geralmente vazias.  A atual pandemia de Covid-19 explica em grande parte a ausência de torcedores. Além de conseguir vistos, é preciso apresentar testes PCRs negativos para embarcar e outro de antígeno na chegada aos Camarões. Além disso, os torcedores também devem apresentar testes negativos de menos de 24 horas, no caso de antígeno, para entrar nos estádios. Para ter acesso a clínicas e laboratórios para fazer o teste é preciso passar várias horas nas longas filas.  Para os camaroneses, outra solução é apresentar um documento comprovando o esquema de vacinação completo. Mas no país, há forte resistência à campanha de vacinação.  Para ouvir o programa, clicar no link acima

Simon Calder's Independent Travel Podcast
January 13th - France Is Open, But There's Much To Consider

Simon Calder's Independent Travel Podcast

Play Episode Listen Later Jan 13, 2022 5:50


France has lifted the travel restrictions for UK travellers as Omicron waves come and go. Hurrah! I hear you shout. But before you dash off to the Eurostar terminal there's still plenty to consider in regards to what you need to have to be able to travel without hassle.PCRs, LFTs and points of entry will all be discussed as I find my way to France when the travel ban is lifted, which is some time on Friday 14th January (they've not actually said when yet.)Of course this podcast is completely free, as is my weekly travel email. You can sign up at independent.co.uk/newsletters. See acast.com/privacy for privacy and opt-out information.

The Two-Minute Briefing
The Evening Briefing: Wednesday, January 5

The Two-Minute Briefing

Play Episode Listen Later Jan 5, 2022 2:07


Testing rules: Day two PCRs scrapped for travellers arriving in UKAnalysis: The latest travel announcement is the best news we could have hoped forPolitics liveblog: Boris Johnson confirms Plan B restrictions to remain for at least three weeksScotland: Sturgeon cuts self-isolation period to seven daysEdward Colston: BLM activists who dumped statue clearedNovak Djokovic: World No1 held at Melbourne Airport after being denied entry to Australia due to visa rowBeating obesity: I learned you can't be fit and fat – when I finally lost weight by eating lessMental restoration holidays: Why you might need an emotional detoxRead all these articles and stay expertly informed anywhere, anytime with a digital subscription. Start your free one-month trial today to gain unlimited website and app access. Cancel anytime. Sign up here: https://bit.ly/3v8HLez.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Manx Radio's Mannin Line
113 new - now 936 cases, 9 in Nobles, 0 in ICU, Peter's newt, Find My Bus, Manx Labour on housing, rogue white lines, foreign travel PCRs & Manx nursing courses. It's Mannin Line with Andy Wint #iom #manninline #manxradio

Manx Radio's Mannin Line

Play Episode Listen Later Dec 10, 2021 49:41


113 new - now 936 cases, 9 in Nobles, 0 in ICU, Peter's newt, Find My Bus, Manx Labour on housing, rogue white lines, foreign travel PCRs & Manx nursing courses, It's Mannin Line with Andy Wint #iom #manninline #manxradio

The Med Mindset Podcast
12. Running PCRs with my woes: demystifying the MD/PhD with Aniruddha Shekara

The Med Mindset Podcast

Play Episode Listen Later Nov 18, 2021 62:33


Each week, we will be bringing you incredible tips, strategies and interviews with phenomenal medical students and residents. You can listen online (below), download it to listen later, on your smartphone: all for free.Now find us on Instagram!In this week's episode, we present our amazing colleague Aniruddha Shekara. Ani's episode was fascinating for many reasons. This interview has been long time coming , hence why we are so excited to share our conversation with Ani. Recently there has been an increased call to action for physicians that possess the wherewithal to translate research from the bench and leverage that in providing the best care to patients. This call has since been amplified due to the apparent need to enhance scientific communication proficiency in light of the kaleidoscope of opinions littered in the discourse surrounding COVID-19.  We should worry not because Ani is on the MD/PhD path. We invite you this week to witness how incredible of a person Ani is and why the future of healthcare is bright simply because he endeavors to help change the world as we know it. He shares with us the thinking behind his decision-making on switching from a premed to becoming a physician-scientist. The additional experiences he sought to make himself a competitive applicant and more were discussed. For this and many more, enjoy this week's episode!In This Week's Podcast, We'll ExploreWhy you should explore being an M.D./PhDMaking the case to justify the funding for the M.S.T.P. programBust the myth behind the M.D./Ph.D. processThe importance of research in medicineHow to seek out physician-scientist mentors How to start an independent research project as an undergradEnriching your gap years with productive experiencesAni's love for musicBooks Mentioned in the PodcastDreamland: The True Tale of America's Opiate EpidemicCrazy: A Father's Search Through America's Mental Health Madness

Jean & Mike Do The New York Times Crossword
Wednesday, September 15, 2021 - WOAH!

Jean & Mike Do The New York Times Crossword

Play Episode Listen Later Sep 16, 2021 8:23


For those of you still recovering from yesterday's jammed-to-the-rafters-with-pop-culture-references grid, the NYTimes proudly presents as an antidote today's puzzle -- with barely a pop culture reference in sight -- thereby keeping the average number of PCRs close to the officially prescribed 3.5 PCRs per grid ... a regulation and a number that we just invented. The theme was cute, involving artificial facial components, and the rest of the clues were equally droll, including such winners as 5A, Put down in writing?, PAN, and 24A, Canine covering?, DENTALCROWN. A nice mid-week effort, we give it a 5 squares on the JAMCR scale.

The Kim Monson Show
The Push to Vaccinate United States Military Personnel

The Kim Monson Show

Play Episode Listen Later Aug 16, 2021 57:15


A new podcast with Lyle Laverty, Former Assistant Secretary of the Interior for Fish, Wildlife and Parks, addresses mismanagement of our forests. Remember the nineteen Republican U.S. senators that helped pass the 2702-page infrastructure bill that was not read by most senators.  They sold us out!  Kabul falls into the hands of the Taliban, and Biden, Harris and Ptaski are MIA.  American personnel are told to “shelter in place.”  How is that going to work out when the Taliban is knocking on the door?  Why were so many military personnel’s lives and their families sacrificed for an ending worse than Saigon? Robyn Carnes, candidate for Centennial City Council, is concerned about local, state, national and international issues.  As a wife and a mother, she recognizes the importance of voting and that local elections have consequences.  Defunding the police will only bring more crime to all neighborhoods.  Divisiveness is rampant with the radical left's narrative.  Anytime the government gets involved there is a negative effect, including housing.  We must take a stand now or Colorado and America will be transformed permanently. Guest Pam Long, former Captain in the Army Medical Service Corps, joins Kim for a discussion on Defense Secretary Lloyd Austin's coerced recommendation that all U.S. military get the experimental drug vaccination for the COVID-19/Wuhan-China virus.  Pam states that this is a very bad policy.  Vaccinations should be voluntary and not coerced or forced for the 46% who refuse; it is actually illegal to mandate the experimental drug jab.  There are 3 exemptions for all branches of the military:  medical, including established immunity; administrative and; religious accommodation.  As an experimental drug vaccination military personnel must ask:  Does it confirm immunity?  Is it a risk when we see people are dying?  Where is the risk assessment as 99.5% survive?  Pam gives startling statistics on those who have taken the vaccination, including 12,000 deaths.  Why mandate?  Follow the money.  Billions of dollars of vaccinations and PCR tests are sitting on shelfs unused and they are all prefunded.  We all must push back on RNA vaccinations as there are many more coming down the pipeline.  The PCR test is a cash cow for institutions, including universities who are mandating the tests.  Note that the CDC has acknowledged that they cannot discriminate influenza from the coronavirus.  Also, a 24 plus cycle rate on PCRs is invalid.  Get the information you need and read.  Start with childrenshealthdefense.org. Feature Image credits: Photo By: Marine Corps Lance Cpl. Sebastian Aponte.

¿Qué más?
186 Superspreader. Coronavirus Chronicles XIX

¿Qué más?

Play Episode Listen Later Aug 8, 2021 67:00


Vicente va a un concierto después de más de un año de confinamiento. Pasaporte sanitario, PCRs y contacto físico. Fiestas ejecutivas donde tiran el dinero por la ventana y bailan música mala. La dictadura de Macron. Daniel espera hasta el final para dar la mejor noticia hasta ahora. Música: Shoes and Socks Off, Emerald Park.

Alineación Indebida
Alineación Indebida: Tratar a las lentejas de usted, lo que ha significado la Euro para España y los pobres PCRs y los ricos a comer canapés

Alineación Indebida

Play Episode Listen Later Jul 7, 2021 71:25


Ander Iturralde da la bienvenida a Rafa Pastrana, Nando Vila y Gonzalo Carol, además de a Cristian Colás en directo desde Wembley, para hablar de todo lo que dio de sí la primera de las dos semifinales, cómo España luchó, fue en muchos aspectos mejor y acabó, sin embargo, cayendo contra la Italia de Donnarumma, Bonucci, Chiellini, Jorginho y Chiesa; el partido, la prórroga, los penaltis y todo lo intermedio; también, los asistentes que fueron a ver el partido en directo; el Intereconomía de Estados Unidos; el fichaje de Junior Firpo por el Leeds; el de Trincao por el Wolverhampton; el estado del Barça; respondemos a las preguntas de los oyentes y mucho más.¡SUSCRÍBETE A ALINEACIÓN INDEBIDA!Escucha el podcast de Nando, "Woke Bros": https://open.spotify.com/show/5IIkaaHQ8IrRLvLjoDXnHnCanal de YouTube de Jacobin, donde Nando hace un programa los Sábados por la mañana: https://www.youtube.com/c/JacobinMag/videosSigue a Ander en Twitter: https://twitter.com/andershoffmanSigue a Nando en Twitter: https://twitter.com/nandorvilaSigue a Rafa en Twitter: https://twitter.com/RafaPastrana7Sigue a Gonzalo en Twitter: https://twitter.com/gonzalocarol29Sigue a Cristian en Twitter: https://twitter.com/crcolasEscucha el nuevo podcast de Ander en inglés sobre la afición por el fútbol: https://open.spotify.com/show/1pMTHZrH44mHPPTN2UbX3dEscucha al podcast de Diego Alonso sobre sus movidas: https://open.spotify.com/show/5cgfeRaBzA7PDNaHRtnibsEscucha el podcast de Cristian Colás, Lorenzo Manchado y Borja García sobre sus movidas: https://open.spotify.com/show/6qhIIb9wYWuT5uIEeTlexRContacto: anderpodcast@gmail.com Our GDPR privacy policy was updated on August 8, 2022. Visit acast.com/privacy for more information.

The Gary Null Show
The Gary Null Show - 07.06.21

The Gary Null Show

Play Episode Listen Later Jul 6, 2021 61:01


Saw palmetto boosts testosterone synthesis Kyung Hee University (South Korea), June 30 2021.   The June 2021 issue of the Journal of Medicinal Food reported the finding of a beneficial effect for saw palmetto against symptoms of andropause in rats.  "Andropause, the male equivalent of menopause, is the set of symptoms caused by the age-related deficiency in male hormones that begins to occur in men in their late 40s to early 50s," Jeong Moon Yun and colleagues explained. "The symptoms of andropause include physical, psychological, and sexual problems, such as fatigue, increased body fat, decreased muscle strength and sexual function, depression, and memory loss." Dr Yun and associates evaluated the effects of an extract of saw palmetto in Leydig cells (in which testosterone biosynthesis occurs) subjected to oxidative stress and in aged rats. In Leydig cells, the administration of testosterone lowered 5 alpha-reductase (which converts testosterone to dihydrotestosterone) and increased total testosterone.  In rats, one of three doses of saw palmetto extract was administered for four weeks. A control group of animals received no treatment. At the end of the treatment period, saw palmetto supplemented rats had significantly less fat tissue weight gain and total weight gain compared to the controls, without a gain in other tissue weight. Serum triglycerides, total cholesterol and the LDL to VLDL cholesterol ratio were also lower in the supplemented groups. Serum total and free testosterone and sperm counts were higher, and sex hormone binding globulin (SHBG) and 5 alpha-reductase levels were lower in all supplemented groups in comparison with the controls. In tests of muscle endurance, rats that received saw palmetto had longer swimming times compared to the control group.  "We suggest that supplementation of saw palmetto may relieve the symptoms of andropause syndrome, including decreased spermatogenesis and muscle endurance and metabolic syndrome by increasing testosterone biosynthesis and bioavailability," the authors concluded.         Diet rich in omega 3 fatty acids may help reduce headaches Trial provides 'grounds for optimism' for many people with persistent headaches and those who care for them University of North Carolina, July 1, 2021 Eating a diet rich in omega 3 (n-3) fatty acids reduces the frequency of headaches compared with a diet with normal intake of omega 3 and omega 6 (n-6) fatty acids, finds a study published by The BMJ today. Modern industrialised diets tend to be low in omega 3 fatty acids and high in omega 6 fatty acids. These fatty acids are precursors to oxylipins - molecules involved in regulating pain and inflammation. Oxylipins derived from omega 3 fatty acids are associated with pain-reducing effects, while oxylipins derived from omega 6 fatty acids worsen pain and can provoke migraine. But previous studies evaluating omega 3 fatty acid supplements for migraine have been inconclusive. So a team of US researchers wanted to find out whether diets rich in omega 3 fatty acids would increase levels of the pain-reducing 17-hydroxydocosahexaenoic acid (17-HDHA) and reduce the frequency and severity of headaches. Their results are based on 182 patients at the University of North Carolina, USA (88% female; average age 38 years) with migraine headaches on 5-20 days per month who were randomly assigned to one of three diets for 16 weeks.  The control diet included typical levels of omega 3 and omega 6 fatty acids. Both interventional diets raised omega 3 fatty acid intake. One kept omega 6 acid intake the same as the control diet, and the other concurrently lowered omega 6 acid intake. During the trial, participants received regular dietary counseling and access to online support information. They also completed the headache impact test (HIT-6) - a questionnaire assessing headache impact on quality of life. Headache frequency was assessed daily with an electronic diary. Over the 16 weeks, both interventional diets increased 17-HDHA levels compared with the control diet, and while HIT-6 scores improved in both interventional groups, they were not statistically significantly different from the control group.  However, headache frequency was statistically significantly decreased in both intervention groups.  The high omega 3 diet was associated with a reduction of 1.3 headache hours per day and two headache days per month. The high omega 3 plus low omega 6 diet group saw a reduction of 1.7 headache hours per day and four headache days per month, suggesting additional benefit from lowering dietary omega-6 fatty acid.  Participants in the intervention groups also reported shorter and less severe headaches compared with those in the control group. This was a high quality, well designed trial, but the researchers do point to some limitations, such as the difficulty for patients to stick to a strict diet and the fact that most participants were relatively young women so results may not apply to children, older adults, men, or other populations.  "While the diets did not significantly improve quality of life, they produced large, robust reductions in frequency and severity of headaches relative to the control diet," they write.  "This study provides a biologically plausible demonstration that pain can be treated through targeted dietary alterations in humans. Collective findings suggest causal mechanisms linking n-3 and n-6 fatty acids to [pain regulation], and open the door to new approaches for managing chronic pain in humans," they conclude. These results support recommending a high omega 3 diet to patients in clinical practice, says Rebecca Burch at the Brigham and Women's Hospital, in a linked editorial. She acknowledges that interpretation of this study's findings is complex, but points out that trials of recently approved drugs for migraine prevention reported reductions of around 2-2.5 headache days per month compared with placebo, suggesting that a dietary intervention can be comparable or better.  What's more, many people with migraine are highly motivated and interested in dietary changes, she adds. These findings "take us one step closer to a goal long sought by headache patients and those who care for them: a migraine diet backed up by robust clinical trial results."     The Southern diet - fried foods and sugary drinks - may raise risk of sudden cardiac death University of Alabama, June 30, 2021  Regularly eating a Southern-style diet may increase the risk of sudden cardiac death, while routinely consuming a Mediterranean diet may reduce that risk, according to new research published today in the Journal of the American Heart Association, an open access journal of the American Heart Association. The Southern diet is characterized by added fats, fried foods, eggs, organ meats (such as liver or giblets), processed meats (such as deli meat, bacon and hotdogs) and sugar-sweetened beverages. The Mediterranean diet is high in fruits, vegetables, fish, whole grains and legumes and low in meat and dairy. "While this study was observational in nature, the results suggest that diet may be a modifiable risk factor for sudden cardiac death, and, therefore, diet is a risk factor that we have some control over," said James M. Shikany, Dr.P.H., F.A.H.A., the study's lead author and professor of medicine and associate director for research in the Division of Preventive Medicine at the University of Alabama at Birmingham. "Improving one's diet - by eating a diet abundant in fruits, vegetables, whole grains and fish such as the Mediterranean diet and low in fried foods, organ meats and processed meats, characteristics of the Southern-style dietary pattern, may decrease one's risk for sudden cardiac death," he said. The study examined data from more than 21,000 people ages 45 and older enrolled in an ongoing national research project called REasons for Geographic and Racial Differences in Stroke (REGARDS), which is examining geographic and racial differences in stroke. Participants were recruited between 2003 and 2007. Of the participants in this analysis, 56% were women; 33% were Black adults; and 56% lived in the southeastern U.S., which is noteworthy as a region recognized as the Stroke Belt because of its higher stroke death rate. The Stroke Belt states included in this study were North Carolina, South Carolina, Georgia, Tennessee, Alabama, Mississippi, Arkansas and Louisiana. This study is the latest research to investigate the association between cardiovascular disease and diet - which foods have a positive vs. negative impact on cardiovascular disease risk. It may be the only study to-date to examine the association between dietary patterns with the risk of sudden cardiac death, which is the abrupt loss of heart function that leads to death within an hour of symptom onset. Sudden cardiac death is a common cause of death and accounted for 1 in every 7.5 deaths in the United States in 2016, or nearly 367,000 deaths, according to 2019 American Heart Association statistics. Researchers included participants with and without a history of coronary heart disease at the beginning of the study and assessed diets through a food frequency questionnaire completed at the beginning of the study. Participants were asked how often and in what quantities they had consumed 110 different food items in the previous year. Researchers calculated a Mediterranean diet score based on specific food groups considered beneficial or detrimental to health. They also derived five dietary patterns. Along with the Southern-style eating pattern, the analysis included a "sweets" dietary pattern, which features foods with added sugars, such as desserts, chocolate, candy and sweetened breakfast foods; a "convenience" eating pattern which relied on easy-to-make foods like mixed dishes, pasta dishes, or items likely to be ordered as take-out such as pizza, Mexican food and Chinese food; a "plant-based" dietary pattern was classified as being high in vegetables, fruits, fruit juices, cereal, bean, fish, poultry and yogurt; and an "alcohol and salad" dietary pattern, which was highly reliant on beer, wine, liquor along with green leafy vegetables, tomatoes and salad dressing. Shikany noted that the patterns are not mutually exclusive. "All participants had some level of adherence to each pattern, but usually adhered more to some patterns and less to others," he explained. "For example, it would not be unusual for an individual who adheres highly to the Southern pattern to also adhere to the plant-based pattern, but to a much lower degree." After an average of nearly 10 years of follow-up every six months to check for cardiovascular disease events, more than 400 sudden cardiac deaths had occurred among the 21,000 study participants. The study found: Overall, participants who ate a Southern-style diet most regularly had a 46% higher risk of sudden cardiac death than people who had the least adherence to this dietary pattern. Also, participants who most closely followed the traditional Mediterranean diet had a 26% lower risk of sudden cardiac death than those with the least adherence to this eating style. The American Heart Association's Diet and Lifestyle recommendations emphasize eating vegetables, fruits, whole grains, lean protein, fish, beans, legumes, nuts and non-tropical vegetable cooking oils such as olive and canola oil. Limiting saturated fats, sodium, added sugar and processed meat are also recommended. Sugary drinks are the number one source of added sugar in the U.S. diet, according to the Centers for Disease Control and Prevention, and the American Heart Association supports sugary drink taxes to drive down consumption of these products. "These findings support the notion that a healthier diet would prevent fatal cardiovascular disease and should encourage all of us to adopt a healthier diet as part of our lifestyles," said Stephen Juraschek, M.D., Ph.D., a member of the American Heart Association's Nutrition Committee of the Lifestyle and Cardiometabolic Health Council. "To the extent that they can, people should evaluate the number of servings of fruit and vegetables they consume each day and try to increase the number to at least 5-6 servings per day, as recommended by the American Heart Association. Optimal would be 8-9 servings per day. "This study also raises important points about health equity, food security and social determinants of health," he continued. "The authors describe the "Southern Diet" based on the U.S. geography associated with this dietary pattern, yet it would be a mistake for us to assume that this is a diet of choice. I think American society needs to look more broadly at why this type of diet is more common in the South and clusters among some racial, ethnic or socioeconomic groups to devise interventions that can improve diet quality. The gap in healthy eating between people with means and those without continues to grow in the U.S., and there is an incredible need to understand the complex societal factors that have led and continue to perpetuate these disparities." This current research expands on earlier studies on participants from the same national stroke project, REGARDS. In a 2018 analysis, Shikany and colleagues reported that adults ages 45 and older with heart disease who had an affinity for the Southern diet had a higher risk of death from any cause, while greater adherence to the Mediterranean diet was associated with a lower risk of death from any cause. And in a 2015 study, the Southern diet was linked to a greater risk of coronary heart disease in the same population. The large population sample and regional diversity, including a significant number of Black participants, are considered strengths of the REGARDS research project. However, potential limitations of this study include that that dietary intake was based on one-time, self-reported questionnaires, thus, it relied on the participants' memory. Self-reported diet can include inaccuracies leading to bias that could reduce the strength of the associations observed. One usual association that remains unexplained is that among individuals with a history of heart disease, those who most adhered to the sweets dietary pattern had a 51% lower risk of sudden cardiac death than participants who followed that pattern the least. Researchers note that they found "no viable explanation for the inverse association of the sweets dietary pattern with risk of sudden cardiac death in those with a history of coronary heart disease."     5-minute workout lowers blood pressure as much as exercise, drugs 'Strength training for breathing muscles' holds promise for host of health benefits University of Colorado, July 2, 2021 Working out just five minutes daily via a practice described as "strength training for your breathing muscles" lowers blood pressure and improves some measures of vascular health as well as, or even more than, aerobic exercise or medication, new CU Boulder research shows. The study, published June 29 in the Journal of the American Heart Association, provides the strongest evidence yet that the ultra-time-efficient maneuver known as High-Resistance Inspiratory Muscle Strength Training (IMST) could play a key role in helping aging adults fend off cardiovascular disease - the nation's leading killer.  In the United States alone, 65% of adults over age 50 have above-normal blood pressure - putting them at greater risk of heart attack or stroke. Yet fewer than 40% meet recommended aerobic exercise guidelines. "There are a lot of lifestyle strategies that we know can help people maintain cardiovascular health as they age. But the reality is, they take a lot of time and effort and can be expensive and hard for some people to access," said lead author Daniel Craighead, an assistant research professor in the Department of Integrative Physiology. "IMST can be done in five minutes in your own home while you watch TV." Developed in the 1980s as a way to help critically ill respiratory disease patients strengthen their diaphragm and other inspiratory (breathing) muscles, IMST involves inhaling vigorously through a hand-held device which provides resistance. Imagine sucking hard through a tube that sucks back.  Initially, when prescribing it for breathing disorders, doctors recommended a 30-minute-per-day regimen at low resistance. But in recent years, Craighead and colleagues have been testing whether a more time-efficient protocol--30 inhalations per day at high resistance, six days per week--could also reap cardiovascular, cognitive and sports performance improvements. For the new study, they recruited 36 otherwise healthy adults ages 50 to 79 with above normal systolic blood pressure (120 millimeters of mercury or higher). Half did High-Resistance IMST for six weeks and half did a placebo protocol in which the resistance was much lower.  After six weeks, the IMST group saw their systolic blood pressure (the top number) dip nine points on average, a reduction which generally exceeds that achieved by walking 30 minutes a day five days a week. That decline is also equal to the effects of some blood pressure-lowering drug regimens.  Even six weeks after they quit doing IMST, the IMST group maintained most of that improvement. "We found that not only is it more time-efficient than traditional exercise programs, the benefits may be longer lasting," Craighead said. The treatment group also saw a 45% improvement in vascular endothelial function, or the ability for arteries to expand upon stimulation, and a significant increase in levels of nitric oxide, a molecule key for dilating arteries and preventing plaque buildup. Nitric oxide levels naturally decline with age.  Markers of inflammation and oxidative stress, which can also boost heart attack risk, were significantly lower after people did IMST. And, remarkably, those in the IMST group completed 95% of the sessions. "We have identified a novel form of therapy that lowers blood pressure without giving people pharmacological compounds and with much higher adherence than aerobic exercise," said senior author Doug Seals, a Distinguished Professor of Integrative Physiology. "That's noteworthy." The practice may be particularly helpful for postmenopausal women. In previous research, Seals' lab showed that postmenopausal women who are not taking supplemental estrogen don't reap as much benefit from aerobic exercise programs as men do when it comes to vascular endothelial function. IMST, the new study showed, improved it just as much in these women as in men.  "If aerobic exercise won't improve this key measure of cardiovascular health for postmenopausal women, they need another lifestyle intervention that will," said Craighead. "This could be it." Preliminary results suggest MST also improved some measures of brain function and physical fitness. And previous studies from other researchers have shown it can be useful for improving sports performance. "If you're running a marathon, your respiratory muscles get tired and begin to steal blood from your skeletal muscles," said Craighead, who uses IMST in his own marathon training. "The idea is that if you build up endurance of those respiratory muscles, that won't happen and your legs won't get as fatigued." Seals said they're uncertain exactly how a maneuver to strengthen breathing muscles ends up lowering blood pressure, but they suspect it prompts the cells lining blood vessels to produce more nitric oxide, enabling them to relax. The National Institutes of Health recently awarded Seals $4 million to launch a larger follow-up study of about 100 people, comparing a 12-week IMST protocol head-to-head with an aerobic exercise program. Meanwhile, the research group is developing a smartphone app to enable people to do the protocol at home using already commercially available devices. Those considering IMST should consult with their doctor first. But thus far, IMST has proven remarkably safe, they said. "It's easy to do, it doesn't take long, and we think it has a lot of potential to help a lot of people," said Craighead.   Research suggests atheroprotective role for chrysin Fu Jen Catholic University (Taiwan), July 1, 2021 According to news reporting originating from New Taipei, Taiwan, research stated, “Atherosclerosis and its related clinical complications are the leading cause of death. MicroRNA (miR)-92a in the inflammatory endothelial dysfunction leads to atherosclerosis.” Our news editors obtained a quote from the research from Fu Jen Catholic University, “Kruppel-like factor 2 (KLF2) is required for vascular integrity and endothelial function maintenance. Flavonoids possess many biological properties. This study investigated the vascular protective effects of chrysin in balloon-injured carotid arteries. Exosomes were extracted from human coronary artery endothelial cell (HCAEC) culture media. Herb flavonoids and chrysin (found in mint, passionflower, honey and propolis) were the treatments in these atheroprotective models. Western blotting and real-time PCRs were performed. In situ hybridization, immunohistochemistry, and immunofluorescence analyses were employed. MiR-92a increased after balloon injury and was present in HCAEC culture media. Chrysin was treated, and significantly attenuated the miR-92a levels after balloon injury, and similar results were obtained in HCAEC cultures in vitro. Balloon injury-induced miR-92a expression, and attenuated KLF2 expression. Chrysin increased the KLF2 but reduced exosomal miR-92a secretion. The addition of chrysin and antagomir-92a, neointimal formation was reduced by 44.8 and 49.0% compared with balloon injury after 14 days, respectively. Chrysin upregulated KLF2 expression in atheroprotection and attenuated endothelial cell-derived miR-92a-containing exosomes.” According to the news editors, the research concluded: “The suppressive effect of miR-92a suggests that chrysin plays an atheroprotective role.” This research has been peer-reviewed.     False-positive mammogram results linked to spike in anxiety prescriptions Penn State University, July 2, 2021 Women who experience a false-positive mammogram result are more likely to begin medication for anxiety or depression than women who received an immediate negative result, according to a study led by Penn State researcher Joel Segel. The finding highlights the importance of swift and accurate follow-up testing to rule out a breast cancer diagnosis. The study found that patients who receive a false-positive mammogram result are also prescribed anxiety or depression medication at a rate 10 to 20 percent higher than patients who receive an immediate negative result. These prescriptions are new and not continuations of previously prescribed medicines. A false-positive result is one where a suspicious finding on the screening mammogram leads to additional testing that does not end up leading to a breast cancer diagnosis. Additionally, within that group of patients who required more than one test to resolve the false-positive there was a 20 to 30 percent increase in those beginning to take anxiety or depression medications. The increase was particularly noticeable among women with commercial insurance who required multiple tests to rule out a breast cancer diagnosis. "The results suggest that efforts to quickly resolve initially positive findings including same-day follow-up tests may help reduce anxiety and even prevent initiation of anxiety or depression medication," said Segel, assistant professor of health policy and administration at Penn State. This study demonstrates that some women who experience a false-positive mammogram may need additional follow-up care to effectively handle the increased anxiety that may accompany the experience, Segel said. More importantly, from a practitioner standpoint, the study identifies sub-populations who may be most at risk of increased anxiety following a false-positive mammogram, Segel said. Specifically, women whose false-positive result requires more than one follow-up test to resolve, women with commercial insurance who undergo a biopsy, women who wait longer than one week to receive a negative result, and women who are under age 50 may all be at higher risk of experiencing clinically significant anxiety or depression. "Regular breast cancer screening is critical to early detection," Segel said. "Patients should continue to work with their providers to ensure they are receiving guideline-appropriate screening and should follow up with their providers if they experience either anxiety or depression following screening or any type of care." Researchers studied commercial- and Medicaid-claims databases to identify women ages 40 to 64 who underwent screening mammography with no prior claims for anxiety or depression medications. The findings recently appeared in Medical Care.     Thymoquinone in Black Seed oil increases the expression of neuroprotective proteins while decreasing expression of pro-inflammatory cytokines Florida A&M University, June 29, 2021    According to news originating from Tallahassee, Florida, research stated, "Neuroinflammation and microglial activation are pathological markers of a number of central nervous system (CNS) diseases. Chronic activation of microglia induces the release of excessive amounts of reactive oxygen species (ROS) and pro-inflammatory cytokines." Our news journalists obtained a quote from the research from Florida A&M University, "Additionally, chronic microglial activation has been implicated in several neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Thymoquinone (TQ) has been identified as one of the major active components of the natural product Nigella sativa seed oil. TQ has been shown to exhibit anti-inflammatory, anti-oxidative, and neuroprotective effects. In this study, lipopolysaccharide (LPS) and interferon gamma (IFN gamma) activated BV-2 microglial cells were treated with TQ (12.5 mu M for 24 h). We performed quantitative proteomic analysis using Orbitrap/Q-Exactive Proteomic LC-MS/MS (Liquid chromatography-mass spectrometry) to globally assess changes in protein expression between the treatment groups. Furthermore, we evaluated the ability of TQ to suppress the inflammatory response using ELISArray ™ for Inflammatory Cytokines. We also assessed TQ's effect on the gene expression of NFKB signaling targets by profiling 84 key genes via real-time reverse transcription (RT2) PCR array. Our results indicated that TQ treatment of LPS/IFN gamma-activated microglial cells significantly increased the expression of 4 antioxidant, neuroprotective proteins: glutaredoxin-3 (21 fold; p< 0.001), biliverdin reductase A (15 fold; p< 0.0001), 3-mercaptopyruvate sulfurtransferase (11 fold; p< 0.01), and mitochondria] Ion protease (> 8 fold; p< 0.001) compared to the untreated, activated cells. Furthermore, TQ treatment significantly (P < 0.0001) reduced the expression of inflammatory cytokines, IL-2 = 38%, IL-4 = 19%, IL-6 = 83%, IL-10 = 237%, and IL-17a = 29%, in the activated microglia compared to the untreated, activated which expression levels were significantly elevated compared to the control microglia: IL-2 = 127%, IL-4 = 151%, IL-6 = 670%, IL-10 = 133%, IL-17a = 127%. Upon assessing the gene expression of NFKB signaling targets, this study also demonstrated that TQ treatment of activated microglia resulted in > 7 fold down-regulation of several NFKB signaling targets genes, including interleukin 6 (IL6), complement factor B (CFB), chemokine (C-C motif) ligand 3 (CXCL3), chemokine (C-C) motif ligand 5 (CCL5) compared to the untreated, activated microglia. This modulation in gene expression counteracts the > 10-fold upregulation of these same genes observed in the activated microglia compared to the controls. Our results show that TQ treatment of LPS/IFN gamma-activated BV-2 microglial cells induce a significant increase in expression of neuroprotective proteins, a significant decrease in expression inflammatory cytokines, and a decrease in the expression of signaling target genes of the NF kappa B pathway. Our findings are the first to show that TQ treatment increased the expression of these neuroprotective proteins (biliverdin reductase-A, 3-mercaptopyruvate sulfurtransferase, glutaredoxin-3, and mitochondrial Ion protease) in the activated BV-2 microglial cells. Additionally, our results indicate that TQ treatment decreased the activation of the NF kappa B signaling pathway, which plays a key role in neuroinflammation." According to the news editors, the research concluded: "Our results demonstrate that TQ treatment reduces the inflammatory response and modulates the expression of specific proteins and genes and hence potentially reduce neuroinflammation and neurodegeneration driven by microglial activation."

Sexo y lo que surja
159. Sexo y lo que surja: Consultorio Sexual

Sexo y lo que surja

Play Episode Listen Later Jul 3, 2021 67:16


En este nuevo programa de Sexo y lo que surja estamos ya un poco cansados de tanto hablar, es verano y necesitamos vacaciones, además hasta nosotros estamos cansados de oírnos, así que hemos preferido escucharos a vosotros. Escuchamos y comentamos los audios tan divertidos que nos habéis mandado y hablamos sobre el semen en la cara, qué consideramos cuernos, las orgías que te saltan a la cara o cuando besas a una persona de tu sexo a causa de la cerveza. Al final en todos sitios cuecen habas (ya podían ser garbanzos) y todos tenemos historias que contar, qué bien hacerlo juntos. En el cajón encontramos un aparatito que al principio pensábamos que era para hacer PCRs, pero al metérselo Juanma por la nariz ha descubierto el gustito que daba su vibración en los piercings, le ha durado poco, Aza ha dicho que pa chulo su chumino y que eso se quedaba en su coño por los siglos de los siglos, amén. Como seguimos sin querer trabajar pues nos recreamos en los minutos de la basura, que son como charlar por zoom con un colega, pero grabando. No podía faltar nuestras expectativas sobre el Numancia, los planes para el finde o fingir que has quedado con más gente para pedir más pizza. 🎧Regístrate aquí para conseguir una historia gratis en Audiodesires: https://audiodesires.com/es/registro/?utm_campaign=sexosurja. 🎀Programa patrocinado por Bijoux Indiscrets https://shopes.bijouxindiscrets.com/ 🧡Dale LIKE🧡 Síguenos en: ➡️Instagram: https://www.instagram.com/sexoyloquesurja2021 ➡️Twitter: https://twitter.com/sexoyloquesurja ➡️Web: https://sexoyloquesurja.com/ ➡️Twitch: https://www.twitch.tv/sexoyloquesurja ➡️Facebook: https://www.facebook.com/seyloque/ 🍆Reserva tu TupperSex en: https://sexoyloquesurja.com/tupper/ o en tupper@sexoyloquesurja.com 💸Ayúdanos a financiar el proyecto en: https://www.patreon.com/sexoyloquesurja 📧Y puedes contactar con nosotros en: sexoyloquesurjablog@gmail.com

Coronavirus: pandèmia global

Analitzem la nova escalada de contagis de Covid i la situaci

TopCatRàdio

Analitzem la nova escalada de contagis de Covid i la situaci

Estado de Alerta
DESLIZ: Susanos Planeros reclaman al Estado Populista el pago de PCRs y turismo vacunatorio

Estado de Alerta

Play Episode Listen Later Jun 29, 2021 15:30


Saúde
Saúde - Epidemia faz crescer ataques cibernéticos e roubo de dados nos hospitais

Saúde

Play Episode Listen Later Jun 8, 2021 4:59


Desde o início de 2020, pelo menos 12 estabelecimentos foram alvo de pirataria na França. Em 2021, foram registrados cerca de 27 ataques, segundo o governo francês. Taíssa Stivanin, da RFI Os ataques cibernéticos utilizam na maior parte do tempo os ransowares, ou malwares sequestradores. Os malwares são conhecidos popularmente como vírus. São chamados de sequestradores porque os programas, depois de invadir o sistema, tomam o controle do acesso aos dados. Os piratas digitais condicionam sua devolução ao pagamento de um resgate. Dados divulgados pela empresa de segurança americana SonicWall revelaram que, no ano passado, quando teve início a crise sanitária, ataques desse tipo sofreram um aumento de 62%. O Brasil foi o nono país mais atingido, com 3,8 milhões de invasões. O setor da saúde foi o segundo mais afetado, com alta de 123% em decorrência da aceleração do processo de digitalização nas empresas. O primeiro foi o varejo, com 365%. Com a crise sanitária e a superlotação dos hospitais, a proteção dos dados dos pacientes também se tornou um desafio para os estabelecimentos. Para o fundador da start-up francesa Steady, Karl Rigal, especializada em consultoria informática, antes da epidemia as informações já não eram suficientemente protegidas. “A frequência e a importância dos ataques aos hospitais e às estruturas públicas e mistas, de um modo geral, aumentaram. Diante da situação atual e da urgência com que a crise sanitária deve ser tratada, os piratas imaginam que, no caso de um ataque desse tipo, será difícil para o estabelecimento recusar uma chantagem caso tenha seu sistema de informação paralisado”, explica. De acordo com o especialista, os ataques cibernéticos tendem a crescer nos próximos anos, a se tornar cada vez mais sofisticados e adaptados ao contexto. Atualmente, são os hospitais que estão no centro dessas operações criminosas, por conta da pandemia de Covid-19. “O que fragilizou os dados é que os sistemas não estão todos bem protegidos. Além disso, com a pandemia, há muitos funcionários que trabalham na parte administrativa dos hospitais, que estão em home office e devem continuar se conectando ao sistema central de informação. O acesso não estava totalmente seguro, criando falhas que facilitaram a ação dos piratas”, detalha Rigal. Ele ressalta que as pessoas que já tinham o hábito de trabalhar em casa tinham computadores com proteções adequadas, mas, com a generalização do home office, não houve tempo para garantir a segurança de todas as conexões. “São 5 milhões de pessoas na França que, de um dia para o outro, passaram a trabalhar em casa”, ressalta. “Basta clicar no e-mail de um pirata que já havia roubado a identidade de uma instituição pública. Sem desconfiar de nada, o usuário acabará autorizando a intrusão no sistema. Acaba sendo fácil para o hacker ter acesso a todos os dados.” A questão é ainda mais delicada quando se tratam de informações sobre a saúde. Karl Rigal explica que é muito mais simples criar perfis falsos tendo à disposição informações confiáveis e confidenciais sobre um indivíduo: número de celular, e-mail, patologias, tratamentos e histórico de hospitalização. Em seguida, basta enviar uma mensagem semanas ou meses depois para o paciente que, provavelmente, vai abrir o e-mail acreditando que ele tenha sido de fato enviado pelo estabelecimento onde esteve internado. A armadilha, em geral, necessita de um clique em um link, o famoso phishing, que possibilitará ao pirata recuperar outros dados, como número do cartão bancário, por exemplo. Vacinação A crise sanitária gera muitas outras oportunidades para os piratas digitais, lembra o especialista em cibersegurança francês. Há também os dados envolvendo os testes PCRs dos pacientes em laboratórios e de vacinação. Por isso, um dos conselhos, por exemplo, é nunca publicar uma foto nas redes sociais do certificado da vacinação, com dados como nome vacina, lote, dados pessoais, data e local da imunização. Na euforia de compartilhar a notícia com a família e os amigos, muitas pessoas acabam se expondo sem ter ideia das consequências. Para Karl Rigal, é preciso sensibilizar as pessoas sobre como se proteger na internet: pensar duas vezes antes de abrir um e-mail, e ficar atento a informações contraditórias. Ele lembra que é importante atrair bons profissionais da área para lutar contra a pirataria digital, dando um sentido ao trabalho que realizam – nesse caso, ajudar os hospitais a protegerem suas informações. Os hackers, lembra, são gênios da Informática que trabalham para o crime organizado. “São jovens que chegam ao escritório às 9h e vão embora às 17h e fazem isso o dia todo. É tudo muito estruturado. Por isso, a resposta também precisa ser estruturada.” Isso significa, diz, tornar o mercado da cibersegurança mais atraente para os engenheiros de computação, quebrando estereótipos e abrindo, também mais o mercado para mulheres.

Capital
Capital Intereconomía Parte 2 08/06/2021

Capital

Play Episode Listen Later Jun 8, 2021 145:19


Análisis de los mercados financieros con Pablo García, director de DIVACONS- Alphavalue. Consultorio de bolsa con Javier Etcheverry, Socio Fundador de Daiko Markets. Foro de la inversión con Raúl Fernández, Director de Distribución de Amundi Iberia. Consultorio de fondos con José María Luna, Socio de Luna-Sevilla Asesores Patrimoniales. Los desayunos de Capital con David Moneo, Director de VO. La justicia europea ha dictado una sentencia que abre la puerta a que los inversores institucionales de la salida a bolsa de Bankia reclamen. Todas las claves con Fernando Zunzunegui, Abogado y profesor de Derecho del mercado financiero en la Universidad Carlos III y socio director de Zunzunegui Abogados. ¿Cómo van a ser nuestras vacaciones de verano?. Entrevista con Eva Aranda, experta en Turismo de Ipsos España. ¿Abuso de precios de las PCRs y antígenos?. Lo comentamos con Juan Carlos Rodríguez Pérez, Presidente Aetel Asociación Española de Técnicos de Laboratorio.

La Linterna
La Linterna (07/06/2021) de 23h a 23.30h: "Sanidad está trabajando sobre un nuevo documento de restricciones"

La Linterna

Play Episode Listen Later Jun 7, 2021 27:15


Monólogo de Expósito. Así está el patio. Resumen del día, con Jon UriarteEsta noche hemos conocido que el Ministerio de Sanidad está trabajando en un nuevo documento sobre las restricciones al ocio nocturno y la hostelería. Un posible cambio de planes a raíz de que la Audiencia Nacional haya paralizado momentaneamente las medidas aplicadas la semana pasada. Acepta las medidas cautelarísimas solicitadas por la Comunidad de Madrid. La vacunación avanza y la curva de contagios sigue bajando. Por lo que hoy España ha reabierto sus puertas al turismo de todo el mundo. Nos podrán visitar personas que estén vacunadas o que cuenten con un negativo en PCRs o antígenos. Solo hay tres excepciones: los que vengan desde Brasil, India y Sudáfrica. Sin embargo, esta norma está generando cierto revuelo en Portugal en las últimas horas. No entienden que desde hoy para entrar en nuestro país por carretera, les exijamos un negativo o haberse vacunado.Escucha 'La Linterna'Ángel Expósito enciende cada día La Linterna de 19 a 23.30 horas. A lo largo de esas cuatro horas y media de radio Expósito te cuenta lo que está pasando, te explica por qué está ocurriendo y te da las principales claves para entenderlo. La Linterna es la suma de la información, el análisis y la opinión.Una...

La Linterna
La Linterna (07/06/2021) – de 22h a 23h: "Hoy España reabre fronteras al turismo de todo el mundo"

La Linterna

Play Episode Listen Later Jun 7, 2021 55:11


Monólogo de Expósito. Tiempo de análisis con Ignacio Camacho y Julio César HerreroEsta noche hemos conocido que el Ministerio de Sanidad está trabajando en un nuevo documento sobre las restricciones al ocio nocturno y la hostelería. Un posible cambio de planes a raíz de que la Audiencia Nacional haya paralizado momentaneamente las medidas aplicadas la semana pasada. Acepta las medidas cautelarísimas solicitadas por la Comunidad de Madrid. La vacunación avanza y la curva de contagios sigue bajando. Por lo que hoy España ha reabierto sus puertas al turismo de todo el mundo. Nos podrán visitar personas que estén vacunadas o que cuenten con un negativo en PCRs o antígenos. Solo hay tres excepciones: los que vengan desde Brasil, India y Sudáfrica. Sin embargo, esta norma está generando cierto revuelo en Portugal en las últimas horas. No entienden que desde hoy para entrar en nuestro país por carretera, les exijamos un negativo o haberse vacunado... cuando ayer NO había ningún tipo de control.Escucha 'La Linterna'Ángel Expósito enciende cada día La Linterna de 19 a 23.30 horas. A lo largo de esas cuatro horas y media de radio Expósito te cuenta lo que está pasando, te explica por qué está ocurriendo y te da las principales claves para entenderlo. La Linterna es la suma...

Laboratorio COVID
Laboratorio COVID 6: Toma Adenovirus en tiempos de pandemia

Laboratorio COVID

Play Episode Listen Later May 2, 2021 40:25


Sexto episodio de Laboratorio COVID donde volvemos a pillar los micrófonos con ganas y puede que sirva para que la toma de Adenovirus en tiempos de pandemia. Tenemos unas puertas abiertas enviando los restultados de las PCRs, un Vórtex breve cargado de contagios, la centrífuga más adenovírica del pódcast, las preguntas y respuestas más dinámicas […] La entrada Laboratorio COVID 6: Toma Adenovirus en tiempos de pandemia se publicó primero en Raúl de la Puente .

Laboratorio COVID
Laboratorio COVID 5: El ARN más famoso con una pizca de grafeno

Laboratorio COVID

Play Episode Listen Later Apr 18, 2021 41:58


Quinto episodio de Laboratorio COVID con tintes culinarios debido a la mezcla de actualidad y nuestra temática en el pódcast de esta semana. Las puertas abiertas resolviendo las PCRs, un Vórtex breve pero aclarando temas médicos, la centrífuga más densa con un ARN que ya lo conoce todo el mundo y, en las preguntas y […] La entrada Laboratorio COVID 5: El ARN más famoso con una pizca de grafeno se publicó primero en Raúl de la Puente .

Valencia Parla
27-03-2021 Mejores Momentos de Valencia Parla

Valencia Parla

Play Episode Listen Later Mar 27, 2021 134:33


Os dejamos con los mejores momentos de la semana de Valencia Parla (de lunes a jueves de 18.00 a 20.00 en la 99.9 Valencia Radio) Abrimos con nuestra TERTULIA DE COSAS DE LA VIDA nos hablan del cambios entre distintas generaciones. Seguimos con nuestra sección de DIRECTO CINE de la mano de Uiso Crespo, hablamos sobre las peores películas del año. Cerramos con nuestra tertulia política: ¿Turismo? ¿Toni Cantó? ¿Pcrs falsas?

Podcast RADIOPROTECTION
# 29 Le burn out des PCRs w/ Sylvie VANNEUVILLE

Podcast RADIOPROTECTION

Play Episode Listen Later Mar 17, 2021 73:23


The Melt Podcast
Max Igan | Historical Resets and Prophetic Scripts

The Melt Podcast

Play Episode Listen Later Mar 5, 2021


I speak with Australian dot-connector Max Igan about questioning the super-narrative, the deeper agenda, internet censorship, the subjective nature of misinformation, COVID “vaccine” as experiment, the Mainframe, the mudflood, the Lucifer System, information vs. wisdom, and the inaccuracy of PCRs. Max’s website: https://thecrowhouse.com/home.html To support The Melt with a monthly subscription fee as low as... Read More

The Melt Podcast
Max Igan | Historical Resets and Prophetic Scripts

The Melt Podcast

Play Episode Listen Later Mar 5, 2021


I speak with Australian dot-connector Max Igan about questioning the super-narrative, the deeper agenda, internet censorship, the subjective nature of misinformation, COVID “vaccine” as experiment, the Mainframe, the mudflood, the Lucifer System, information vs. wisdom, and the inaccuracy of PCRs. Max’s website: https://thecrowhouse.com/home.html To support The Melt with a monthly subscription fee as low as... Read More

EMS on AIR
S2:E26 - "EMS Patient Care Reports - The Rules of the Game." Recorded February 12, 2021

EMS on AIR

Play Episode Listen Later Mar 5, 2021 28:39


This episode is the second in a four-part series focusing on EMS patient care reports, or PCRs. This series has been developed in collaboration with the Oakland County Medical Control Authority (OCMCA) and various EMS providers as a way of providing information and guidance to EMS agencies and personnel. Although we reference the OCMCA and our local and State EMS protocols, this series is beneficial to all EMS agencies and providers. In this episode, we discuss the value of EMS PCRs. Primarily, our goal is to increase EMS’ appreciation and awareness of the value and relevance of EMS patient care documentation, as well as how to implement best practices into their work. To accomplish the goal, our guests help us aappreciate the hierarchy and role of laws related to EMS documentation, administrative rules, EMS protocols, and agency policies and how they all work in concert to cultivate quality and consistency amongst EMS patient care documentation. Then, we’ll list and describe applicable protocols related to drafting and submitting EMS patient care records. Visit EMSonAIR.com for the latest information, podcast episodes and other details. Follow us on Instagram @EMSOnAIR. Please keep emailing your questions, comments, feedback and episode ideas to the EMS on AIR Podcast team by email at QI@OCMCA.org. Geoff Lassers, Paramedic EMS-IC (QI@ocmca.org)Host, EMS on AIR PodcastEMS System Manager, Oakland County Medical Control Authority (OCMCA)Firefighter / Paramedic, West Bloomfield Fire DepartmentAmerican CME, Director of EducationGuests:Bonnie Kincaid (Bonnie@ocmca.org)Executive Director, Oakland County Medical Control Authority (OCMCA)Emily Bergquist, MSA, Paramedic, EMS-IC (BergquistE@michigan.gov)State of Michigan MCA Coordinator, MDHHS, BETPEmily Baker, BS, Paramedic, EMS-IC (emily.holstine@ascension.org)EMS Coordinator, Ascension Providence SouthfieldCQI Supervisor, Alliance Mobile HealthJohn Theut, MS, Paramedic, EMS-IC (Qi@ocmca.org)QA/QI Coordinator, Oakland County Medical Control Authority (OCMCA)Shift Captain / EMS Coordinator, Ferndale Fire Department Support the show (https://www.patreon.com/emsonair?fan_landing=true)

EMS on AIR
S2:E25 - "The Value of EMS Patient Care Reports." Recorded February 12, 2021

EMS on AIR

Play Episode Listen Later Mar 5, 2021 69:10


This episode is the first in a four-part series focusing on EMS patient care reports, or PCRs. This series has been developed in collaboration with the Oakland County Medical Control Authority (OCMCA) and various EMS providers as a way of providing information and guidance to EMS agencies and personnel. Although we reference the OCMCA and our local and State EMS protocols, this series is beneficial to all EMS agencies and providers. In this episode, we discuss the value of EMS PCRs. Primarily, our goal is to increase EMS’ appreciation and awareness of the value and relevance of EMS patient care documentation, as well as how to implement best practices into their work. To accomplish the goal, our guests help us: Appreciate the value of consistency and quality when drafting a PCR. Then, we’ll list and describe benefits experienced by patients, EMS providers, EMS agencies or systems and hospitals regarding consistency and quality when drafting a PCR. And finally, describe current data and trends identified in PCR quality assurance and quality improvement initiatives found throughout Michigan and the US. Visit EMSonAIR.com for the latest information, podcast episodes and other details. Follow us on Instagram @EMSOnAIR. Please keep emailing your questions, comments, feedback and episode ideas to the EMS on AIR Podcast team by email at QI@OCMCA.org. Geoff Lassers, Paramedic EMS-IC (QI@ocmca.org)Host, EMS on AIR PodcastEMS System Manager, Oakland County Medical Control Authority (OCMCA)Firefighter / Paramedic, West Bloomfield Fire DepartmentAmerican CME, Director of EducationGuests:Bonnie Kincaid (Bonnie@ocmca.org)Executive Director, Oakland County Medical Control Authority (OCMCA)Emily Bergquist, MSA, Paramedic, EMS-IC (BergquistE@michigan.gov)State of Michigan MCA Coordinator, MDHHS, BETPEmily Baker, BS, Paramedic, EMS-IC (emily.holstine@ascension.org)EMS Coordinator, Ascension Providence SouthfieldCQI Supervisor, Alliance Mobile HealthJohn Theut, MS, Paramedic, EMS-IC (Qi@ocmca.org)QA/QI Coordinator, Oakland County Medical Control Authority (OCMCA)Shift Captain / EMS Coordinator, Ferndale Fire DepartmentSupport the show (https://www.patreon.com/emsonair?fan_landing=true)

EMS on AIR
S2:E27 - "EMS Patient Care Reports - Data Elements and Requirements." Recorded February 16, 2021

EMS on AIR

Play Episode Listen Later Mar 5, 2021 36:11


This episode is the third in a four-part series focusing on EMS patient care reports, or PCRs. This series has been developed in collaboration with the Oakland County Medical Control Authority (OCMCA) and various EMS providers as a way of providing information and guidance to EMS agencies and personnel. Although we reference the OCMCA and our local and State EMS protocols, this series is beneficial to all EMS agencies and providers. In this episode, we discuss the value of EMS PCRs. Primarily, our goal is to increase EMS’ appreciation and awareness of the value and relevance of EMS patient care documentation, as well as how to implement best practices into their work. To accomplish the goal, our guests help us list and describe the terminology related to PCR data entry. Then, we list and describe the minimum data elements that must be completed in the PCR of an EMS transport of a patient. From there, we’ll discuss the additional elements required in the PCR of an EMS transport patients with time sensitive emergencies. We round out the discussion by listing and describing the minimum data elements that must be completed in the PCR of an EMS patient care refusal, an EMS patient Dead on Scene and an EMS Termination of Resuscitation in the field.Visit EMSonAIR.com for the latest information, podcast episodes and other details. Follow us on Instagram @EMSOnAIR. Please keep emailing your questions, comments, feedback and episode ideas to the EMS on AIR Podcast team by email at QI@OCMCA.org. Geoff Lassers, Paramedic EMS-IC (QI@ocmca.org)Host, EMS on AIR PodcastEMS System Manager, Oakland County Medical Control Authority (OCMCA)Firefighter / Paramedic, West Bloomfield Fire DepartmentAmerican CME, Director of EducationGuests:Bonnie Kincaid (Bonnie@ocmca.org)Executive Director, Oakland County Medical Control Authority (OCMCA)Emily Bergquist, MSA, Paramedic, EMS-IC (BergquistE@michigan.gov)State of Michigan MCA Coordinator, MDHHS, BETPEmily Baker, BS, Paramedic, EMS-IC (emily.holstine@ascension.org)EMS Coordinator, Ascension Providence SouthfieldCQI Supervisor, Alliance Mobile HealthJohn Theut, MS, Paramedic, EMS-IC (Qi@ocmca.org)QA/QI Coordinator, Oakland County Medical Control Authority (OCMCA)Shift Captain / EMS Coordinator, Ferndale Fire Department.Support the show (https://www.patreon.com/emsonair?fan_landing=true)