Podcasts about islets

Tom Gerencer joins us to discuss the book The Top of the Volcano: The Award-Winning Stories of Harlan Ellison, which contains 11 stories not included in Harlan Ellison's Greatest Hits. Stories discussed: A Boy and His Dog (1:39), The Region Between (37:12), Basilisk (48:29), Adrift Just Off the Islets of Langerhans: Latitude 38° 54' N, Longitude 77° 00' 13" W (53:57), Croatoan (1:05:55), Count the Clock that Tells the Time (1:16:45), With Virgil Oddum at the East Pole (1:32:30), Soft Monkey (1:41:43), The Function of Dream Sleep (1:47:38), The Man Who Rowed Christopher Columbus Ashore (2:01:01), The Human Operators (2:11:50). Learn more about your ad choices. Visit megaphone.fm/adchoices

Sto sedmý díl Lootboxu už vždy bude v dějinách kvalitního herního podcastingu zapsaný jako ten, kde nám David pověděl o tom jak se vrátil k Lords of the Fallen! Kromě toho jsme zase udělali takzvaný parkour a dali kulturní okénko na začátek, popovídali si o dealování drog a nějakých těch JRPGs.

This week I chat about Islets and RKGK, and answer some listener questions about open world games, the best ever consoles, underrated indies, '80s movies, pineapple on pizza, and lots more besides. And as always, thanks to all the show's patrons, including new patrons Shaun, Adam, Ant, and Madeleine. If you'd like to join them in supporting the show on Patreon, and getting bonus patron episodes and a Discord invite, you can do so at http://patreon.com/gaminginthewild. You can also send a one-off tip via Ko-Fi at http://ko-fi.com/gaminginthewild. Thanks, it all helps! You can come say hi on Twitter, Instagram, YouTube and Twitch - find all the links at http://gaminginthewild.com. And check out this Steam curator page made by podcast supporter DovetailTrue: https://store.steampowered.com/curator/43457463-Gaming-in-the-Wild-%2528unofficial%2529/   Music this week: ‘Grass Valley' and ‘Iridescent Creatures' from Islets, and ‘Possum Springs' from Night in the Woods. Thanks for listening!

WORLD: China ships spotted near Japan-controlled islets | May 28, 2024Subscribe to The Manila Times Channel - https://tmt.ph/YTSubscribe Visit our website at https://www.manilatimes.net Follow us: Facebook - https://tmt.ph/facebook Instagram - https://tmt.ph/instagram Twitter - https://tmt.ph/twitter DailyMotion - https://tmt.ph/dailymotion Subscribe to our Digital Edition - https://tmt.ph/digital Check out our Podcasts: Spotify - https://tmt.ph/spotify Apple Podcasts - https://tmt.ph/applepodcasts Amazon Music - https://tmt.ph/amazonmusic Deezer: https://tmt.ph/deezer Stitcher: https://tmt.ph/stitcherTune In: https://tmt.ph/tunein #TheManilaTimessAX Hosted on Acast. See acast.com/privacy for more information.

Wars were once fought over the control of bird poop. We talk about how Peruvian animal feces ends up in the US and Europe. -- Connect: www.privy-cast.com Social and Contact Links: linktr.ee/privycast Follow Hunter -- Give Thanks, Give Back: Wounded Warrior Project Living Water International -- Music:  Intro and Outro Derived from: "Barroom Ballet" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/by/4.0/ - Transition Music: "Whispering Stream" by E's Jammy Jams https://www.youtube.com/playlist?list=PLKCo4y0JbV2a7azDkmbIlyYtWzQdaDwiM -- Sources: https://en.wikipedia.org/wiki/Chincha_culture https://en.wikipedia.org/wiki/Chincha_Islands https://en.wikipedia.org/wiki/Chincha_Islands_War https://en.wikipedia.org/wiki/Guano_Islands,_Islets,_and_Capes_National_Reserve_System https://www.britannica.com/place/Peru/Achievement-of-independence https://agencevu.com/en/serie/les-forcats-du-guano-au-perou-iles-chincha-2014/

Frodo jugó #islets y Refe se fue a #coralisland. Roy está por ahí... Unite a nuestro grupo de Facebook: AFKGamingPodcast  Unite a nuestro Discord: https://discord.gg/Z2McTXX Nuestro canal de Youtube: LINK Encontranos en nuestras redes sociales! RoyMust4ng : Twitch.tv + Twitter Refe: Twitch.tv + Facebook Frodo: Facebook

It is what it is, pal. Games we played this week include: Content Warning (11:00) MiG Switch (17:50) Rise of the Ronin (27:50) Islets (35:40) Final Fantasy VII: Rebirth (43:30) Pepper Grinder (54:50) Final Fantasy X (1:00:05) --- News things talked about in this episode: ESRB claims software designed to age verify isn't intended to be used by children (1:01:35) https://www.eurogamer.net/us-government-blocks-age-estimation-technology-that-would-have-analysed-faces After massive sell-offs, Embracer doesn't think it's ready to start acquiring again (54:10) https://www.rockpapershotgun.com/embracer-say-their-restructure-is-over-but-its-too-early-to-start-acquiring-studios-again --- Buy official Jimquisition merchandise at https://thejimporium.com Find Laura at LauraKBuzz on Twitter, Twitch, YouTube, and Patreon. All her content goes on https://LauraKBuzz.com, and you can catch Access-Ability on YouTube every Friday. Follow Conrad at ConradZimmerman on Twitter/Instagram/BlueSky and check out his Patreon (https://patreon.com/fistshark). You can also peruse his anti-capitalist propaganda at https://mercenarycreative.com.

On this day in 1960, the John Pennekamp Coral Reef State Park was established as the first underwater nature preserve in the United States. See omnystudio.com/listener for privacy information.

fml tivemos um problema com o audio entao tive que upar o audio do vod (nao que faça muita diferença tb, apoiem a gente pra podermos contratar um editor pros podcasts um dia) O Periscópio é gravado quinzenalmente na quinta, às 10h, lá na twitch.tv/nautiluslink Participantes: Host: Lucas Zavadil | @lucaseduardrz Convidado: hernique | @hernique777 Apoie o projeto e permita que ele continue: apoia.se/nautilus Encontre-nos também nas redes sociais: Discord: bit.ly/DiscordNautilus Twitter: twitter.com/nautiluslink Instagram: instagram.com/nautiluslink

Graham and Steve return from Persia to talk about the upcoming games of March, Prince of Persia: The Lost Crown, and more, with some Must Listens thrown in for good measure! Show Segments: 00:00 - Intro 3:26 - Graham's Games 49:14 - Steve's Games 59:58 - Beginning of the End (March releases discussion) Games Mentioned: A Plague Tale: Requiem Sea of Stars The Talos Principle II Prince of Persia: The Lost Crown I am Future Tekken 8 Islets Sky Settlers Balatro Lost Castle Prince of Persia: The Lost Crown Episode's YouTube Video: This episode on YouTube SIPTG YouTube Channel: https://www.youtube.com/c/shouldiplaythisgamequestionmark Music by Kevin MacLeod: https://incompetech.com/music

Graham and Steve sit back down to chit-chat about the games they've played over the last couple of weeks, the (sometimes) pedantic intricacies of vMix, and the Super Bowl! Go segues! Show Segments: 00:00 - Intro 4:10 - Steve's Games 35:22 - Graham's Games 59:09 - Beginning of the End Games Mentioned: The Talos Principle II Lightyear Frontier Skull and Bones Phantom Abyss Helldivers: Dive Harder Tekken 8 Anomaly Agent Lil' Guardsman WitchHand Industria Islets Hawked Episode's YouTube Video: This episode on YouTube SIPTG YouTube Channel: https://www.youtube.com/c/shouldiplaythisgamequestionmark Music by Kevin MacLeod: https://incompetech.com/music

Episode 83 Games discussed: Astrea: Six-Sided Oracles, Islets, Pokemon Heart Gold, Pokemon Gold. Topics discussed: Xbox vs PlayStation, general consumerism, environmentalism in gaming/gaming carbon footprint, and fomo in gaming - do we always need to buy the new game? https://isp.page/news/how-much-carbon-do-video-games-emit-industrys-co2-footprint-revealed/   Twitch: Brandon @ stickymunchkin https://www.twitch.tv/stickymunchkin Blake @ handheldblake   Please subscribe to our Youtube channel and please support us on Patreon. You can also find us on Instagram and TikTok. https://www.patreon.com/thestickybuttonspod https://www.youtube.com/channel/UCSJvGgcb44cEp6nQrMxCz1g

We recap all of the announcements and trailers from the THQ Nordic Digital Showcase 2023 plus we also discuss Baldur's Gate 3, Baldur's Gate: Enhanced Edition, Viewfinder, Islets and Disfigure.

This isn't a crisis, this is your life. These wise words arrived at my mental doorstep a few weeks back, and they stopped me in my tracks. How might I – and we – make space to breathe and reflect, to name and collectively acknowledge the losses and changes that have impacted us all in different ways over the last three years?  Opening Hymn- Come Sing a Song With Me (:29) Words of Welcome & Call to Worship- Dr. Glen Thomas Rideout (3:02) Time for All Ages- Rev. Jen Crow (7:51) Breathing Meditation- Dr. Glen Thomas Rideout (17:47) Message- This Isn't a Crisis; This is Your Life- Rev. Jen Crow (23:11) Meditation and Cycle of Life- Rev. Jen Crow (52:28) Reflection on Stewardship- Shelley des Islets- (57:14) Invitation to Give and Receive- Rev. Ashley Harness (1:03:18) Offertory- Light of a Clear Blue Morning by Dolly Parton- Dr. Glen Thomas Rideout (1:04:13) Benediction- Rev. Jen Crow (1:08:51)  

Kirby from Disaster Tourism joins us today to talk about Adrift off the Islets of Langerhans https://spacepenguin.ink Check out more from disaster tourism https://disastertourism.games/ From our Sponsor Spicy Tuna: https://constant-downpour.backerkit.com/hosted_preorders --- Send in a voice message: https://podcasters.spotify.com/pod/show/wobbliesandwizards/message Support this podcast: https://podcasters.spotify.com/pod/show/wobbliesandwizards/support

Quizmasters Lee and Marc meet for a trivia quiz with topics including Sports, Video Games, Hollywood, Geography, History, Anatomy, Literature, Music and more! Round One SOCCER - In soccer, how many yellow cards result in a red card? VIDEO GAMES - Originally released by Nintendo, what was the top-selling non-Atari game released for the Atari 2600? HOLLYWOOD - What actor (also the father to four sons named Peter, Eric, Michael and Joel, who also work in the TV and film industry as actors and producers) was born Isur Danilovic? U.S. GEOGRAPHY - Yellowstone National Park is located primarily in which U.S. State? ANATOMY - In which large gland of the human body would you find the Islets of Langerhans? HOUSEPLANTS - A popular type of indoor plant is Chlorophytum comosum, which gets its common name from what kind of creature? Round Two JAMES BOND - What James Bond film stars Pierce Brosnan, Michelle Yeoh and Teri Hatcher, features a theme song by Sheryl Crow, and was the first in the series to be released after the death of long-time franchise producer Albert R. Broccoli? PSYCHOLOGY - Ergophobia is the irrational fear of what? FAST FOOD - Which international fast food chain opened its first location in Lexington, KY in 1969 and takes its name from a main character of a novel first published in the early 1880's? LANDMARKS - What landmark is nicknamed Le Dame de Ferr (which translates to "Iron Lady")? AFRICAN HISTORY - What capital city of Somalia controlled the East African gold trade for several centuries and was also the birthplace of supermodel Iman? LITERATURE - Which book, often read in high school, begins "When he was nearly 13, my brother Jem got his arm badly broken at the elbow"? Rate My Question FLAGS - What island nation, which gained independence from the U.K. in 1962, is the only country to not feature any of the colors red, white, or blue on its flag? Final Questions THE BEATLES - What Beatles song released in 1967 features backing vocals from such notable musicians as Mick Jagger, Keith Richards, Marianne Faithfull, Keith Moon, Eric Clapton, Graham Nash and others? ANATOMY - Located on the head, what part of the body's name is sometimes used by those in the medical field as a backronym to help remember that part's five primary components? Upcoming LIVE Know Nonsense Trivia Challenges March 22nd, 2023 - Know Nonsense Challenge - Point Ybel Brewing Co. - 7:30 pm EST March 23rd, 2023 - Know Nonsense Trivia Challenge - Ollie's Pub Records and Beer - 7:30 pm EST March 25th, 2023 - FRIENDS TRIVIA - Know Nonsense Challenge - Point Ybel Brewing Co. - 7:30 pm EST You can find out more information about that and all of our live events online at KnowNonsenseTrivia.com All of the Know Nonsense events are free to play and you can win prizes after every round.

On this episode, Jonathan is joined by Noel Morgan, Professor of Endocrine Pharmacology, University of Exeter, UK. The pair discuss Morgan's extensive research in diabetes, including his research on islet biology and signalling mechanisms regulating pro-inflammatory and anti-inflammatory processes in β-cells in Type 1 diabetes. They further discuss areas of research that excite and frustrate him, how we can change beliefs and behaviours associated with diabetes, and the future of diabetes research.   Use the following timestamps to navigate the topics discussed in this episode:   (00:00)-Introduction (02:00)-Morgan's origin story (03:30)-Experiences from Nashville, USA (06:00)-Islet biology (08:00)-Insulin secretion control (12:25)-Aetiology and differences between Type 1 and Type 2 diabetes (15:10)-The largest collection of rare pancreas samples in the world (17:50)-Different ‘types' of Type 1 diabetes (20:15)-Pro-insulin (22:35)-To B or not to B? (24:35)-Rituximab (26:00)-Dorothy Hodgkin Lecture (28:00)-The global obesity epidemic and changing behaviour (31:45)-The war on obesity (33:40)-A longer, unhealthy life? (34:45)-Exciting topics and immunotherapy (36:50)-Three wishes

1️⃣0️⃣8️⃣ En Hadoken número 108, esta vez es Aureal el que por motivos personales (vete a saber), se ausenta del programa, si bien el resto del equipo médico habitual está presente para decir las tontunas habituales durante tres horas. 🔮 Empezamos con los rumores que sitúan Switch Pro en la campaña de Navidad junto al DLC de Pokémon Escarlata y Púrpura. 💨 Seguimos con rumores, como los que rodean a Ubisoft, todo lo que tiene que ver con la llegada de Metroid Prime 2, 3 y 4 a NS y los 5 triple A del grupo Embracer de aquí al 2028. 💰 Luego debatimos sobre si las compañías debieran cobrar dinero o no por seguir apoyando sus títulos post lanzamiento como afirma Sweary, el creador de Deadly Premonition. 📺 Y terminamos la actualidad con gameplays de juegos como Layers of Fear, Islets o The Thaumaturge. 🥩 Y de solomillo, un top con nuestros niveles favoritos de los 8 y 16 bits.

Join Reid as he speaks with child psychologist Dr. Shoshana Levin Fox about how she diagnoses and treats children with Autism Spectrum Disorder (differently than most practitioners). They discuss the methods she uses to assess children, such as DIR Floortime, and some unique terms, such as Islets of Normalcy, derived from her work of 25 years at the Feuerstein Institute in Jerusalem. In her view, many children today are actually misdiagnosed as autistic.They often have other kinds of developmental challenges which are overshadowed by the autism diagnosis. In their talk Shoshana explains how she works to detect these other developmental challenges. There are key tips for parents, too in this episode! https://shoshanalevinfox.com/

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.01.518652v1?rss=1 Authors: Han, Y., Yang, J., Li, Y., Cen, Y., Ren, H., Ding, R., Qian, W., Ren, K., Xie, B., Deng, M., Xiao, Y., Chu, J., Zou, P. Abstract: As fast developing tools for observing cellular membrane potential, red-emitting genetically encoded voltage indicators (GEVIs) reduce auto-fluorescence background, allow multiplexed recordings, and enable all-optical electrophysiology, but have been limited by either insensitivity or dimness. Here, we report a pair of red GEVIs, Cepheid1b/s, with improved sensitivity, brightness, and photostability. Cepheid1 indicators faithfully report cellular excitability in pancreatic islets and neural activity in acute brain slices. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Autism Outside the Box In this episode I talk with child psychologist Dr. Shoshana Levin Fox about how she diagnoses and treats children with ASD differently than do most practitioners. We discuss the methods she uses to assess children, such as DIRFloortime, and some unique terms, such as Islets of Normalcy, derived from her work of 25 years at the Feuerstein Institute in Jerusalem. In her view, many children today are actually misdiagnosed as autistic. They often have other kinds of developmental challenges which are overshadowed by the autism diagnosis. In our talk Shoshana explains how she works to detect these other developmental challenges. There are key tips for parents, too. This is a very interesting episode. You can find out more about her in the link below. Dr. Shoshana Levin Fox is the author of An Autism Casebook for Parents and Practitioners: The Child Behind the Symptoms. In her book, she shares her unique way of assessing and treating autism-diagnosed children. Shoshana's website is shoshanalevinfox.com

Autism Outside the Box In this episode I talk with child psychologist Dr. Shoshana Levin Fox about how she diagnoses and treats children with ASD differently than do most practitioners. We discuss the methods she uses to assess children, such as DIRFloortime, and some unique terms, such as Islets of Normalcy, derived from her work of 25 years at the Feuerstein Institute in Jerusalem. In her view, many children today are actually misdiagnosed as autistic. They often have other kinds of developmental challenges which are overshadowed by the autism diagnosis. In our talk Shoshana explains how she works to detect these other developmental challenges. There are key tips for parents, too. This is a very interesting episode. You can find out more about her in the link below. Dr. Shoshana Levin Fox is the author of An Autism Casebook for Parents and Practitioners: The Child Behind the Symptoms. In her book, she shares her unique way of assessing and treating autism-diagnosed children. Shoshana's website is shoshanalevinfox.com

Inspired By Metroid makes its triumphant return, this time focusing on Islets, a surprisingly wholesome Metroidvania. Andy is joined by Omega Metroid Reporter Daniel Hoctor to examine the story of a little mouse named Iko as he tried to reunite the five seperate pieces of his home island and restore his world! Does Islets rise to the occasion, or is this a Metroidvania that Metroid fans should let sink to the depths? Come find out! Islets is available on all major platforms, and special shout out to our other Omega Metroid Reporter GameWyrm for suggesting this title!   Subscribe! Podbean x iTunes x Spotify Support us on Patreon! Omega Metroid Patreon Follow us on Twitter! @OmegaMetroidPod x @Spiteri316 x @dakcity_ x @DoominalCross Chat with us in Discord! Omega Metroid Discord Advertise on the Omega Metroid Podcast!

The Metal Geeks crew reconvenes after George returned from his whirlwind trip to Disney World and Universal Studios. We discuss his entire trip, and how it was being inside the Disney bubble during a Hurricane. We also discuss some of our favorite new metal releases, and other topics include Islets on the Nintendo Switch, Doom 3 BFG, Hellraiser, Hocus Pocus 1 and 2, Smile, Werewolf By Night, and so much more! Join the Metal Geeks Society today on Facebook and join in on all the geekery! Join us on our website at http://www.metalgeekspodcast.com or http://www.metalgeeks.net to keep up with all the geekery. Email us your opinions and ideas at msrcast@gmail.com. Follow us on Twitter, @metalgeeks, and @msrcast. You can now find us on Instagram, at @metalgeeks. Find us on Facebook/MetalGeeks. Subscribe to Metal Geeks Podcast on iTunes, please leave a 5-star review on iTunes and a like us whilst you are there. You can also find us on Stitcher as well as on Google Play. We are now also on Spotify, so jam us into your playlist! Don't forget to pay a visit to all of our affiliates including ESOnetwork.com, where you can find all of the killer shows that make up the ESO Podcast network. You can now get some killer Metal Geeks merchandise over at redbubble.com/people/metalgeeks including t-shirts and more!

The Metal Geeks crew reconvenes after George returned from his whirlwind trip to Disney World and Universal Studios. We discuss his entire trip, and how it was being inside the Disney bubble during a Hurricane. We also discuss some of our favorite new metal releases, and other topics include Islets on the Nintendo Switch, Doom … Metal Geeks 225: Hellraising Geekery Read More » The post Metal Geeks 225: Hellraising Geekery appeared first on The ESO Network.

We round up some of the standout demos from Steam NextFest including games like Gunbrella, Asterigos: Curse of the Stars, Nine Years of Shadows and The Case of the Golden Idol plus Frank gives his first impressions of the Steam Deck and we talk Beacon Pines and Islets.

Trasformiamo in tradizione (?) l'esperimento fatto l'anno scorso proponendovi un'ora abbondante di chiacchiera su svariati videogiochi indie assaporati durante il periodo estivo. Little Orpheus (03:00). Card Shark (08:50). Sephonie (13:37). Neon White (19:50). Deer Journey (26:10). Cursed to Golf (30:40). Apotheorasis • Lab of the Blind Gods (35:50). Islets (44:45). Freud's Bones (50:10). Vesper (57:54). The Last Clockwinder (01:03:20). Buon ascolto! Soundtraccia: Outcast Magazine - Davide Tosini

We debate Sony's recent Playstation 5 price increase and the announcement that couch coop is being cut from Halo Infinite plus we also talk Immortality, Yakuza 0, Islets, Nonozle, Horizon Forbidden West and Teenage Mutant Ninja Turtles: The Cowabunga Collection.

The games really do keep coming now, as this week's podcast the gang have been playing Saints Row. Adam and Chris Hyde have played some co-op and also some of the game on their own, and have some interesting thoughts about all things Saints Row.   Elsewhere, Lyle, Adam, and Chris Hyde have all played Tinykin, and think it's adorable and shouldn't be a game people ignore (hence talking about it on the podcast), and then, before the listener correspondence mega-reveal, Adam went to Nintendo HQ to play some Splatoon 3 and is totally in on that game, but wants to see more of the new stuff.   ► Join our Discord: https://discord.gg/EGQUs9d9 ► Support us via Patreon: http://Patreon.com/GodisaGeek  ✔ SUBSCRIBE: http://www.youtube.com/subscription_center?add_user=GodisaGeek

Welcome to this episode of Ferret64 with me, YemmytheFerret! This episode covers Video Game news and Occurrences between 8-22 through 8-28-22 including: Everything revealed at GamesCom 2022, Saints Row, Midnight Fight Express, Islets, Re-Volt, Amazon not buying EA, Embracer Group buys studios, Resident Evil Show cancelled, Steelrising Beta, New PS5 controller, Beer Brewing Simulator, Sifu update, and more! Thanks for listening on all platforms! Song in the intro and outro: Night Shade - Adhesive Wombat. TimeStamps: 00:33 - Intro, 01:35 - Gamescom, 49:52 - What I've Been Playing, 1:07:43 - News and Coming soon

Well this week isn't all Splatoon 3 news, but we've certainly got a lot of it. Outside of the big splash of direct news we've got tons of new indies and a supercharged turbo mode.The Jordan Harbinger ShowApple Best of 2018-Learn the stories, secrets & skills of the world's most fascinating pplListen on: Apple Podcasts Spotify The Enthusiasm ProjectDeep dives exploring the world of what it means to be an independent creator.Listen on: Apple Podcasts SpotifySupport the show

Llega el Episodio 96 de Si No Sabes, Pacote Metes, en el que repasamos todas las novedades de esta semana en cuanto a videojuegos, con muchas, muchas noticias que cubrir (para sorpresa de todos). Para esta nonagésima sexta entrega, tenemos a 2 de las voces clásicas del podcast, como son @Rodin y @ALCAMJI. A lo largo de esta entrega hablarán de Spider-Man en PC, las peleas entre Microsoft y SONY, el 8 aniversario de PT, PlayStation Games for PC, EA y los sobres del FIFA, reboots y remakes, entre muchas otras novedades, además de un nuevo sorteo con Slitherine Games. Para seguir el programa, podéis fijaros en las siguientes divisiones de tiempo: 0:00 - Presentación e inicio 2:30 - Qué hemos visto/jugado esta semana 1:16:00 - Spider-Man sale en PC y en Xbox Series X… gracias a un usuario + Comparativa PS4 vs PS5 1:28:50 - PlayStation Games for PC, la nueva landing de SONY 1:35:55 - Se filtra una lista de juegos de SONY para PC por parte de GeForce 1:40:00 - Electronic Arts cree por completo que a los jugadores les gustan los sobres de FIFA 1:49:50 - Islets, un nuevo metroidvania que llega el 24 de agosto para Xbox, Switch y PC 1:54:25 - THQ Nordic anuncia Alone in the Dark Reboot 2:03:20 - Anuncian remake de Gothic 2:05:15 - Anuncian Outcast 2 A New Beginning 2:10:00 - Microsoft responde a SONY por sus críticas en sus compras y el GamePass 2:12:45 - Se cumplen 8 años de PT, la demo de Silent Hills 2:14:40 - Se actualizan los datos financieros de Take2 y Red Dead Redemption 2 es el 9o juego más vendido de la historia 2:21:45 - Nuevo sorteo de la mano de Slitherine Games - Cómo participar 2:28:40 - Nueva demo técnica de Unity a 4k en PS5 2:29:50 - Un juego sobre una ardilla que va por la calle robando a personas. Sí, nos quedamos igual que tú 2:30:25 - Hiroyuki Kobayashi, productor de Dino Crisis, se marcha de CAPCOM 2:32:30 - Se atrasan Metal Slug Tactics y Hogwarts Legacy para 2023 2:33:10 - Fortnite y Dragon Ball colaboran. Más el 16 de agosto 2:35:10 - Filtran información sobre una PS5 Slim, que se anunciaría este año 2:35:45 - Nintendo anuncia Kirby Dream Buffet para Nintendo Switch, y ya con fecha 2:37:00 - Se podrá jugar a Forspoken en Series X/S desde el Día 1 2:38:10 - Xenoblade Chronicles 3 y Switch Sports como los juegos más vendidos en julio en España 2:41:00 - Descubren un modo oculto en Super Punch Out. Sí, ahora 2:41:30 - Fan crea un juego de Attack on Titan y ya puedes descargarlo 2:42:45 - Moonscars ya tiene fecha y nuevo trailer 2:43:10 - Disney+ sube de precio 2:46:10 - Disney consigue los derechos de la última saga de Bleach 2:47:00 - Despedida y cierre Y si quieres encontrar todos esos enlaces a hilos que hemos mencionado a lo largo del podcast, aquí te dejamos el enlace por el que tienes que pasarte, dedicado a esta entrega: https://pacot.es/t/spider-man-en-pc-thq-nordic-saca-sus-juguetes-y-predator-vs-dexter-e96-snspm/124525 Además, hemos creado una playlist especial con los temazos que hemos mencionado en este episodio y anteriores, y que podéis encontrar en este enlace: https://www.youtube.com/playlist?list=PL85jWzMr0coA0QeK-xVu5QIkGwiPx7vec Como siempre, queremos que este podcast sea el inicio de la conversación, no el final de la misma, así que esperamos todos vuestros comentarios sobre los temas tratados en este episodio y que os juntéis a la conversación iniciada en el hilo del podcast. Por supuesto, también queremos conocer vuestra opinión del formato del podcast, cómo está editado y cualquier tipo de feedback que nos haga mejorar, tanto en el podcast, como en el Magazine y en todo el foro en general, porque esto es por y para vosotros. ¡Nos vemos en el foro! https://pacot.es/ Magazine: https://pacot.es/c/magazine/ Patreon: https://www.patreon.com/pacotes Youtube: https://www.youtube.com/c/pacotes Twitter: @Pacot_es Facebook: https://www.facebook.com/PacotesWeb/ Instagram: https://www.instagram.com/pacot.es/ --- iVoox: https://www.ivoox.com/escuchar-pacote... Spotify: https://open.spotify.com/show/0JJmaxm... Google Podcasts: https://podcasts.google.com/feed/aHR0...Apple Podcasts: https://podcasts.apple.com/es/podcast... ------------ Música usada en la intro y la outro: Artist: Infraction Song: Synthwave Game Boy Link: https://www.youtube.com/watch?v=WF5aGUayoUE

Welcome to another episode of Ferret64 with your host, YemmytheFerret. This episode covers video game news and occurrences between 8-7 and 8-13-22 including: Cult of the Lamb, Plate Up!, I Love You Colonel Sanders, Star Fox: Assault, THQ Nordic Showcase 2022, Splatoon 3 showcase, games delayed (including: Hogwarts Legacy, Marvel's Midnight Suns, Metal Slug Tactics, River City Girls 2, Arc Raiders), Samoyed Skin in Call of Duty Plagiarized, Battalion 1944 splits from Square Enix, Press X for Trophies, Kirby's Dream Buffet, Islets, and much more! Thanks for listening on all platforms! Song in the intro and outro: Night Shade - Adhesive Wombat. TimeStamps: Intro - 34:00, What I've Been Playing - 01:31, Video Game News - 46:22, Coming Soon - 58:42

Often we conflate a child to a diagnosis. We look at the characteristics of the diagnosis and we expect the child in question to resemble that summary. We forget that not only is each child unique, but each child has strengths that overflow the summary of the diagnosis and give us HOPE.Mentorships in Education is brought to you by Just Education, LLC and is hosted by Judith Epstein. Judi has a Master's degree in Education with a concentration in Language Acquisition. She is certified in special education with post-graduate coursework and professional development in Cognitive Behavior therapy (CBT), Social Thinking, Collaborative and Proactive Solutions (CPS), and Acceptance and Commitment Therapy (ACT). Judi created Just Education, LLC and its podcast component, to compile a free resource library for mentors of students who struggle and address a wide variety of topics that are all related to education and student success.Connect With Dr. Shoshana Levin FoxWebsiteAn Autism Casebook for Parents and Practitioners Review of An Autism CasebookFacebookLinkedInAbout Dr. Shoshana Levin FoxDr. Shoshana Levin Fox is a Jerusalem-based child psychologist, play therapist, autism specialist and the author of the parent-friendly An Autism Casebook for Parents and Practitioners: The Child Behind the Symptoms. Between 1992 and 2017, she worked at the renowned Feuerstein Institute in Jerusalem, where she was responsible for the dynamic assessment and treatment of children who had been diagnosed as autistic.  She has shared her wealth of experience using play-based methods to assess and treat young autistic children at numerous worldwide conferences, in professional publications, and most recently in her book, An Autism Casebook.  (Her personal journey led from small town Ohio, to Boston, to Vancouver, B.C. to Jerusalem.)CONNECT WITH USConnect with Judi Our website and podcasts are available hereJudi on Linkedin

Episode #220 of the Max Level Podcast. On today's show, Bryan and Kyle from rpgera.com take a break from moving items and rearranging rooms to discuss New World finally, as well as Unpacking and Moonglow Bay. From there, a bit more disappointing news has surfaced this past week about Overwatch 2 and Diablo IV. Is it time to say Rest in Peace and just move on? Plus, Helms of Fury on Kickstarter for Kickstart My Heart! Email the show at ldgpodcast@leveldowngames.com with questions, feedback, suggestions, or whatever else you want! Thanks to the following Executive Producers: Sevren and JoetheChode. Timestamps for this episode are as follows: 00:00:42 - Introductions 00:03:54 - New World 00:12:36 - Unpacking 00:19:46 - Moonglow Bay 00:24:15 - The Sean Waltman Lightning Round (News Roundup) 00:36:04 - New Release Roulette (Week of 11/8/21) 00:42:49 - RIP Overwatch 2 & Diablo IV? 00:52:50 - Kickstart My Heart (Helms of Fury) 00:58:55 - Final Words SUPPORT US Patreon: https://patreon.com/rpgera GAME CHALLENGE LINKS Bryan's Completed Games for 2021 Kyle's Completed Games for 2021 Dan's Completed Games for 2021 Sean's Completed Games for 2021 CONTACT US Website: https://rpgera.com Discord: https://discord.gg/cC73Heu Twitch: https://twitch.tv/leveldowngames Twitter: https://twitter.com/OriginalLDG Instagram: https://instagram.com/bryan.ldg/ Facebook: https://facebook.com/leveldowngaming MUSIC CREDIT Most music tracks were provided by Midnight Danger and used with permission He can also be found on Soundcloud, Spotify, Twitter, Instagram, and YouTube! Kickstart My Heart: "Kickstart My Heart -Eurobeat Remix-" by Turbo Ad Read: "Song of Elune" from World of Warcraft, copyright by Blizzard MISC INFORMATION This episode's Sean Waltman Lightning Round consists of the following being discussed: SEGA, Microsoft, Devolver Digital, Honor of Kings: World, Nintendo Switch, Marvel's Avengers, Xbox Game Pass, PlayStation Now, & Islets. --- Send in a voice message: https://anchor.fm/maxlevel/message

~~~LAUREN'S HOUSEKEEPING SECTION~~~ Deadline for our 1st anniversary call-in show is AUGUST 14th. Call us or email us with your questions, comments, concerns, parody songs: Voicemail: 443-584-6486 Email: teixeira.lauren@gmail.com; deohringer@gmail.com T-SHIRTS: Help Lauren go (deeper) into the black by buying a t-shirt! All shirts come with a handwritten, personalized, DNA-laden post-it. Buy one today! ourstruggle.store ~~~DREW'S VOLUMINOUS NOTES SECTION~~~ Updike's spunkcrusted house is yet another paternal demesne Martin Anus, our anxious Bloomian fils, must scrub and bleach and empty. This Augean task (following Wood following Bellow) mandated, then, that Martin purchase Denis de Rougemont's Love In The Western World, which comes adorned with a rather ejaculatory blurb from Updike himself. Martin finds the book immediately intoxicating--after all it's from a time before jargon had colonized scholarship, when criticism was an enchanting expedition. It explores troubadours and heretical Catholic sects, there's something about love itself being a cult of suffering and death, but Martin doesn't trouble himself over abstractions and theories.  He reads with appetite, as though the book were a novel unfurling grandly before him. De Rougemont performs a wide-eyed reading through of the myth of Tristan and Isolde; so Martin goes to Dunkin Donuts and listens to Wagner in the drive-thru. Oh, right, the Tristan chord; slightly more intriguing in Radiohead's iteration, perhaps. He loses interest, switches to Uncle Neil, beautiful bright eunuch sludge sounds: once there was a friend of mine who died a thousand deaths. He's supposed to be thinking about that flat Nord again, though--it's Sunday: time, as Lauren says, to get on the horn. Rosie Gray's coming on, another supplicant, buzzing with ideas about My Struggle ˆvia Grey Gardens. Cathars and askesis are so much chatter right now. Myth, enchantment, wonder, spells--his iced coffee gives him this little litany.  Rosie and Lauren, it turns out, are ready for wonderment and mythos. They rhapsodize on Karl Ove's diluvian fantasies and guillotine imaginings as they work their way towards the squalid paternal domain. Grandma's delirious, the sofa's caked with shit, this is almost a horror movie. Rosie delivers her thoughts on the rich decrepitude of Little Edie and Big Edie and helpfully reminds Martin Anus of Martin Amis's hideous and excruciating orthodontia (as featured in Experience, the only book, we learn, that has induced tears in M. Anus). They realize that Karl Ove probably can't tolerate the existence of Belgium. Lauren makes some perceptive connections between literary flaneurs and detective fiction. And Martin Anus tries to show that this episode's passage traces a shift, in Karl Ove's mind---a shift, perhaps, that's also embodied in the novel form itself--from the mythically grand to the mundanely specific.

In today's episode, we circumnavigate the Islets of Langerhans to the Foramen of Magendie. We encounter the gluttonous inducing Ghrelin and search for the cryptic splenunculus. No, this is not a fantasy novel. We are instead talking about the wonderful world of anatomical terminology. So fasten your gubernacula and let's discuss our favourite anatomical terms. 

“Collect moments and not items” Angela Giannioti Greece tops the travel bucket list of most, if not all travel enthusiasts. This famous country is popular for its beautiful landscape and its ancient history. Yet apart from the identified tourist spots, what you should also look forward to as you visit Greece, is the experience that the people and their culture have to offer.  This is according to our guest today, Angela Giannioti, who gives us a sneak peek into what entails the best experiences lived and collected when visiting Greece Angela Giannioti, fondly referred as Aggeliki, is a travel and adventure lover, and has been working in the travel industry for some years. Angela was born and raised in the US by Greek parents and later moved to Greece where she has been living since 1992. In 2018, she established a destination management company called Greece Adventure Trips, a professional services company with in-depth local knowledge, expertise and resources, working in the design and implementation of events, activities, tours, transportation and travel packages covering each and every corner of the amazing Greece. Greece Adventure Trips organizes and implements travel packages and one day tours in selected areas of Epirus ranging from the dreamed Zagorohoria; the imposing Tzoumerka; the uniquely beautiful Thesprotia (Acheron River); Western Macedonia; the magical Prespes; the unique national park of Pindos of the Peloponnese; a huge outdoor museum; the Ionian Islands with the crystal clear turquoise waters; the dazzling Mykonos; Santorini, the center of western civilization; the vibrant Athens; Crete that simply has it all, and other "hidden gems" all over Greece. In today's episode, we will be discussing about experiencing Greece through connecting with the people and their culture as well as the most recommended sites to experience as a first-time visitor to Greece and even during subsequent visits. Listen in! Social Media LinkedIn: https://www.linkedin.com/in/aggeliki-giannioti-6aa55082 LinkedIn: https://www.linkedin.com/company/greece-adventure-trips FB business page: https://www.facebook.com/greeceadventuretrips FB personal account: https://www.facebook.com/aggeliki.giannioti FB Business group page: https://www.facebook.com/groups/GreeceAdventureTrips   Instagram: https://www.instagram.com/greece_adventure_trips/ YouTube: https://youtube.com/channel/UCtrLGvqQVW3EBRYSSUi9TEA Since my childhood I have loved travelling and discovering new things and places. [3:33] I also enjoy setting up special programs and seeing new things especially in Greece. [3:58] What I love about travelling is getting in touch with the local people and their way of life and making friends. [4:28] When you go to the places where the people who live there go, you truly experience something authentic about the culture and get to experience things that you never would. [6:09] When I visit a place, I want to get a real feeling of that place and carry back memories and also enlarge me perspective [6:37] Sometimes people can be intimidated going to a country where the language is so different. [7:50] As long as you are trying and know enough hand gestures, the more you interact with the locals the less intimidating it becomes. [8:10] Being part of something that is guided and directed for you not only gives you a sense of comfort but also gives you opportunity to see things that are not only tourist stops [10:25] I love talking to people before their trip so as to understand their expectations and what they would like to experience during their trip [11:08] Having an insider tailoring your itinerary based on your personality ensures you have blast [11:34] I do believe that travel industry offers so many alternatives to cover everyone's needs. [17:03] Commercial Break [18:00] Greece is a country with many Islands and Islets and having to choose one or two is difficult. [18:54] If it is the first time, Athens is a must considering the rich history and culture the city has to offer. [19:15] Santorini Island is also a good destination for first time visitors. [19:34] For visitors that have already visited the two, and considering the current need for maintaining less crowding, the three places I would recommend are Amorgos Island, Sifnos Island and Naxos Island which can all be combined in an itinerary. [19:55] In the mainland, Epirus region which has interesting culture, great food, lakes and rivers as well as the coastline of the Ionian Sea. [21:33] Start dreaming and why not start planning our next trip? [25:58] …………………………………………… Thank you to our June Sponsor: &Marketing U Solopreneurs and small businesses often struggle to create effective digital marketing programs. It's hard to know where to start, what to prioritize, how to sift through confusing information and solutions that seem too good to be true. Agencies and full-time marketing employees are expensive! &Marketing U is a modern marketing course with all the tools, education, and accountability you need to grow your business without that extra set of hands or high overhead costs. You will learn exactly what you need to do to execute a concrete marketing strategy by dedicating just 2-4 hours per week. &Marketing U will help you execute: Strategy, Messaging, Content Marketing, SEO, Social Media, Paid Digital Advertising, and more. You'll have access to on-demand resources, live courses, group coaching sessions, community forums and networking, plus the exact templates and tools you need for success. Our CPO took this course and one of the biggest benefits we gained was developing a competitive strategy that aligned our social media playbook and website to generate highly qualified leads. For all the tools, education, and accountability you need to grow your small business at a fraction of the cost of hiring a traditional agency or additional employees, go to:  www.and-marketing.com/u, and use the code SHOCK to receive 10% off any program!    

This episode marks an important milestone. It has been exactly a year since we started recording remotely for a few weeks, to flatten the curve! This in turn means that exactly enough time has elapsed to allow the return of special guest, Ricky McCormack! Neil Fitzpatrick is now but a distant, Danish memory. Thanks to Sentinel Audio for giving us a home.

Fikri and Ezzah get together to sembang some news of Malaysian cinema in the past weeks and months. At the forefront is a discussion about Emir Ezwan's ‘Roh' being selected as the nation's submission for the Academy Awards in 2021. This is followed by a chat about ‘Puteri Gunung Ledang' being on Netflix, powered largely by Ezzah's enthusiasm. Finally, they spend more time on Namewee's film ‘Babi' and ‘The Story of Southern Islet' by Chong Keat Aun; though both have gained acclaim elsewhere, at home they have not been received all that well…

Sunday, December 13, Julica Hermann de la Fuente, our Director of Anti-Racism and Anti-Oppression Ministries, offers a Question Box Sermon. Do you have a burning inquiry about anti-racism and anti-oppression work, especially as it applies to our congregation? We create the message together when you provide the questions for the sermon part of our worship service. Words of Welcome - Rev. Justin Schroeder (:22) Story for All Ages - The Wonder Box- Julica Hermann de la Fuente (3:04) Sermon - Question Box - Julica Hermann de la Fuente (13:48) Anthem - Make Them Hear You, from Ragtime - First Universalist Choir, Dr. Randal Buikema, conductor, Dominique Wooten Embretson, soloist, Franco Holder, piano, First Universalist Instrumentalists, Shelley des Islets, editor (40:33)  

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.30.273839v1?rss=1 Authors: Turki, T., Taguchi, Y.-h. Abstract: Analyzing single-cell pancreatic data would play an important role in understanding various metabolic diseases and health conditions. Due to the sparsity and noise present in such single-cell gene expression data, analyzing various functions related to the inference of gene regulatory networks, derived from single-cell data, remains difficult, thereby posing a barrier to the deepening of understanding of cellular metabolism. Since recent studies have led to the reliable inference of single-cell gene regulatory networks (SCGRNs), the challenge of discriminating between SCGRNs has now arisen. By accurately discriminating between SCGRNs (e.g., distinguishing SCGRNs of healthy pancreas from those of T2D pancreas), biologists would be able to annotate, organize, visualize, and identify common patterns of SCGRNs for metabolic diseases. Such annotated SCGRNs could play an important role in speeding up the process of building large data repositories. In this study, we aimed to contribute to the development of a novel deep learning (DL) application. First, we generated a dataset consisting of 224 SCGRNs belonging to both T2D and healthy pancreas and made it freely available. Next, we chose seven DL architectures, including VGG16, VGG19, Xception, ResNet50, ResNet101, DenseNet121, and DenseNet169, trained each of them on the dataset, and checked prediction based on a test set. We evaluated the DL architectures on an HP workstation platform with a single NVIDIA GeForce RTX 2080Ti GPU. Experimental results on the whole dataset, using several performance measures, demonstrated the superiority of VGG19 DL model in the automatic classification of SCGRNs, derived from the single-cell pancreatic data. Copy rights belong to original authors. Visit the link for more info

Diabetes affects over 2 million people in Canada, but what is diabetes and how can we treat it? In this episode of Nerdin’ About we speak with Dr. Krishana Sankar about her PhD research where she combined biology and engineering to explore improving treatments for diabetes. We give some love to the often forgotten and under-appreciated islets of Langerhans, learning about their role in diabetes, and how "going with flow” can help in our efforts to improve islet transplantation. In addition to studying diabetes, Dr. Sankar founded the #150minutes campaign to increase awareness of diabetes and encourage 150 minutes of exercise each week. Dr. Sankar is also the founder of GradWriteSlack, an online community supporting graduate students in their writing. A transcript of the episode can be found here: https://bit.ly/3ggaOFW

Led by the music ministry of our choir and orchestra, we are held by exquisite voices and sounds, as we prepare our hearts to make our Holiday Gifts to BLUU (Black Lives of Unitarian Universalism.) Back on November 17, we invited the congregation to consume less this holiday season, to live into our core values, and to re-imagine what joy and justice might look like this holiday season. This Sunday, we pooled our gifts (from the money we didn’t spend this holiday season) to support the work of BLUU.  Call to Worship by Holiday Giving Team Members (:31) Fantasia on Christmas Carols, Part 1, Shelley des Islets, Libretto (2:12) Holiday Giving Team Members Reflection (6:16) Fantasia on Christmas Carols, Part 2, Shelley des Islets, Libretto (10:32) Homily, Rev. Justin Schroeder (13:00) Holiday Giving Offering to Black Lives of Unitarian Universalism (23:00) Fantasia on Christmas Carols, Part 3, Shelley des Islets, Libretto (26:22)

Immune tackles the finding that patients with Type I diabetes have lymphocytes with both TCR and BCR that may drive the pathogenesis of the disease. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Dual receptor lymphocytes and type I diabetes (Cell) Image credit Time stamps by Jolene. Thanks! Weekly Science Picks Steph- Unique Scientists Cindy- Researcher app Vincent- STLR Conversations Podcast Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

This podcast is part of the 2017 NSH Symposium/Convention Poster Podcast Series.  The lead author of this poster is Christine Reichard. For more information on the author and to view the abstract, visit The Block.

Their 1988 album The Trinity Session is one of the most heralded in Canadian history, and now they're back on the road for a string of intimate evenings. This week, Cowboy Junkies' Alan Anton joins Mike to chat about the current tour, their ongoing legacy, a songwriting approach borrowed from Elton John,and more. Plus, after years working with one of Canada's best-known management firms, Tim des Islets launched his own company, Noisemaker Management, in 2015. We check in to see what the past 12-plus months have produced, his thoughts on some pressing issues, and more.

Applied Molecular Imaging of Dopaminergic Circuitry in the Islets of Langerhans f/ Paul Emerson Harris, Ph.D.

The Season of the Witch is over, and your High Priest and Priestess of Satanic Schlock Cinema are back with a demonic vengeance! This time out, they take on the 1975 movie, RACE WITH THE DEVIL! It’s a manly film, filled with men doing manly things in a manly way! Oh, and there are crazy cultists a-plenty. Also: is Monster Energy Drink really an instrument of the Devil? Cootie and X investigate! Throw in Ask the Goat, Drinking with the Devil and America’s favorite game of skill and chance, Three Questions, and you’ve got an audio program! Listen to it with your ears and feel it in your Islets of Langerhans!

Type 1 diabetes is a chronic progressive autoimmune disorder with complex, polygenic susceptibility. Environmental factors which are poorly defined also contribute to the pathogenesis. This disease is characterized by lymphocyte infiltration into the islets of Langerhans in the pancreas, leading to inflammation and selective destruction of the insulin-producing beta cells resulting in hyperglycemia.

Abstract Considering the globally increasing rate of incidence, Type 2 diabetes mellitus belongs to the most frequent endocrine metabolic disorders today. In addition to insulin resistance of peripheral tissues, this disease is the result of dysfunction of the endocrine pancreas and in particular of the functional failure of β-cells. The progress of therapeutical strategies is based on the research of the underlying mechanisms. The aim of the present dissertation was the analysis of new molecular regulators which might improve our underdstanding of the differentiation of pancreatic islets and the functional maintenance of adult β-cells. The first part of this work concerned the role of the transcription factor Pax6 and especially the role of its transactivation domain (TA) and of its two DNA binding domains, the paired domain (PD) and the homeodomain (HD), in differentiation of pancreatic endocrine cells. By analyzing four different mouse lines with specific mutations in one of these three domains, we found that the PD of Pax6 is essential for differentiation of glucagon producing α-cells. Inactivation of this domain resulted in a phenotype similar to that of Pax6 knockout mice (Pax6-/-) with a near complete absence of glucagon positive α-cells, a markedly reduced number of insulin producing β-cells, and a disorganized islet structure. Mutations of HD or TA showed a less severe pancreatic phenotype. Islets either exhibited no morphological changes or they showed a reduction of α- and β-cells. Intraperitoneal glucose tolerance tests demonstrated the utmost importance of the transcription factor Pax6 for maintenance of normal pancreatic endocrine function in adult animals. In the second part of this study we identified new genes and proteins, respectively, which could play a regulatory role in normal function of β-cells. In particular it was possible to show that Eny2, hitherto a protein only described in yeast or invertebrates like drosophila, is involved in the regulation of insulin secreting vertebrate cells. si-RNA mediated knockdown of Eny2 resulted in markedly increased glucose and incretin-induced insulin secretion. This could be at least in part attributed to a higher glucose-dependent cellular metabolism and an enhanced signal transduction via protein kinase A and is accompanied by elevated levels of intracellular calcium. Taken together, these results indicate that Eny2 functions as a negative regulator of glucose-stimulated and incretin-mediated insulin secretion, at least in vitro. However, a gap of knowledge still remains between the established nuclear functions of Eny2 and the cellular phenotype we observed upon its suppression. Nevertheless, the effects of an Eny2-knockdown are glucose dependent and additive to the incretin signaling. This feature makes this model attractive to obtain new insights in how insulin secretion of β- cells proceeds and how to find new therapeutical strategies to treat type 2 diabetes mellitus.

Guest: G. Alexander Fleming, MD Host: Bruce Bloom, DDS, JD Researchers are looking at hundreds of ways to treat and cure type one diabetes. Most of the advances so far have come in newly diagnosed children. Is there anything on the horizon to help adults with established type one diabetes? Dr. Alexander (Zan) Fleming, chairman and chief medical officer of Exsulin, joins host Dr. Bruce Bloom to discuss the new therapies for reversing established diabetes.

Guest: G. Alexander Fleming, MD Host: Bruce Bloom, DDS, JD Researchers are looking at hundreds of ways to treat and cure type one diabetes. Most of the advances so far have come in newly diagnosed children. Is there anything on the horizon to help adults with established type one diabetes? Dr. Alexander (Zan) Fleming, chairman and chief medical officer of Exsulin, joins host Dr. Bruce Bloom to discuss the new therapies for reversing established diabetes.

Background: Ischemia/reperfusion (I/R) injury plays a pivotal role in the development of graft pancreatitis, with ischemia time representing one of its crucial factors. However, it is unclear, whether exocrine and endocrine tissue experience similar inflammatory responses during pancreas transplantation (PTx). This study evaluated inflammatory susceptibilities of islets of Langerhans (ILH) and exocrine tissue after different preservation periods during early reperfusion. Methods: PTx was performed in rats following 2 h (2h-I) or 18 h (18h-I) preservation. Leukocyte-endothelial cell interactions (LEI) were analyzed in venules of acinar tissue and ILH in vivo over 2 h reperfusion. Nontransplanted animals served as controls. Tissue samples were analyzed by histomorphometry. Results: In exocrine venules leukocyte rolling predominated in the 2h-I group. In the 18h-I group, additionally, high numbers of adherent leukocytes were found. Histology revealed significant edema formation and leukocyte extravasation in the 18h-I group. Notably, LEI in postcapillary venules of ILH were significantly lower. Leukocyte rolling was only moderately enhanced and few leukocytes were found adherent. Histology revealed minor leukocyte extravasation. Conclusion: Ischemia time contributes decisively to the extent of the I/R-injury in PTx. However, ILH have a significantly lower susceptibility towards I/R, even when inflammatory reactions in adjacent exocrine tissue are evident. Copyright (C) 2010 S. Karger AG, Basel

Here is Live and Direct episode #2, "Auddities" in a slightly edited podcast (i added two songs; think of it as the Deluxe Remastered Podcast Edition). It weighs in at 62.5MB and clocks in at 1:08:15. (I ran over due to excess blabbing... good thing the hosts of the show after mine couldn't make it :)"Auddities" = "audio" + "oddities". These run the gamut from odd sounds to unusual production techniques to strange content. I divided the show up into the following sections, each followed by the approximate starting time (should you wish to skip to a particular section):Introduction, 0:00:00Algorithmic music, 0:00:42MIDI music, 0:04:52Tracked music, 0:10:20Sample-heavy music, 0:19:35(note for upstate NY peeps: Rochester/Vertex shoutout @0:33:30)Digitally produced music, 0:34:00Numbers stations (The Conet Project PDF; music: disc 1, disc 2, disc 3, disc 4), 0:42:40Natural phenomena (Electric Enigma PDF; music: disc 1, disc 2), 0:50:10Music about odd things, 0:54:46Wrap-up, 1:07:18The playlist for this show is as follows:A Poke Cheer (links 1, 2, and 3), Atari basic source code by Lloyd BurchiliRule 150 Binary, Java source code by Paul Reiners (IBM)*Rule 150 All Binary, Java source code by Paul Reiners (IBM)Fanfare, Ultima 3: Exodus, composed by Kenneth W. ArnoldTowns, Ultima 3: Exodus, composed by Kenneth W. ArnoldBubble Bobble theme, composed by David Whittaker, Tim Follin, and Peter ClarkeM.U.L.E. theme, composed by Roy GloverRunaway Scales, composed by U4iaGods theme, Nation 12 (composed by "John Foxx"/Dennis Leigh)The Queen and I, 1987, KLFHouse of the Dead, The Big Cahoona, SequencialAnna Denies Tattoo Rumor, Purveyors of Reason and Law, Quelnt (8bit peoples), Irdial-DiscsIiPP Three, Islets in Pink Polypropylene, Anthony Manning, Irdial-DiscsThe Lincolnshire Poacher, The Conet Project, Irdial-DiscsPhonetic Alphabet NATO, The Conet Project, Irdial-DiscsFish Rock Road Whistler Shower, Electric Enigma, Stephen McGreevy, Irdial-DiscsEves River Auroral Chorus, Electric Enigma, Stephen McGreevy, Irdial-Discs*The Power of Lard [explicit lyrics], Power of Lard, LardPlea From a Cat Named Virtue, Reconstruction Site, The Weakerthans* only on the Deluxe Remastered Podcast EditionAgain, thanks for listening. Your feedback is always welcome.

Histo-morphological analyses after xenogeneic Transplantation mikroencap-sulated Islets of Langerhans in the Model „Pig-in-Rat“ Summary The aim of this study was the detailed histological and immunohistochemical analyzation of microencapsulated xenogeneic islet grafts in previously streptozotozin (STZ)-diabetic Wistar WU rats. Microencapsulated porcine islets of Langerhans (mpLI) were transplanted intraperitoneal and under the left renal capsule of these rats without any medical immune suppression. New insights were to be gained into the cell-mediated reactions of the recipi-ent to the microencapsulated foreign cells and into the fibrosis of the grafts and their ne-ovascularization with the goal of establishing an effective therapy for type I diabetes with this form of xenogeneic islet cell transplantation (xITX). Complex immunohistochemical assays were established to accomplish this goal. When no species-specific antibodies or antisera were available, the cross reaction of human-specific reagents was used. This work analyses in retrospect the data of 18 animals following the implantation of empty micro-capsules and 65 animals that underwent xenotransplantation. The following questions were examined: 1. How long will non-encapsulated and alginate-encapsulated porcine islets of Langerhans function in STZ-diabetic Wistar WU rats? 2. How is the biocompatibility of empty alginate microcapsules in vivo in different transplantation sites and with different exposure times? 3. How do alginate-microencapsulated porcine islets of Langerhans behave in differ-ent transplantation sites and with different exposure times? Special attention was given to the vitality of the islet cells, the fibrosis and neovasculariza-tion of the microcapsules, and the inner cell infiltrates. The most important results were: 1. As expected, 20 of the 64 transplanted rats lost their non-encapsulated grafts by day +5. The 44 microencapsulated grafts evolved into two groups; those with short-term function (n=30; up to day +40) and those with long-term function (n=14; up to day +502). Criteria for the graft function were normoglycemia (daily testing of the blood glucose levels) and body weight. 2. Empty alginate microcapsules showed an excellent biocompatibility up to 200 days after implantation; they kept their original form and size; few inflammatory cells developed (no more than in a normal wound healing process); no neovasculariza-tion or fibrosis was evident on the empty capsules. 3. The microencapsulated islets of Langerhans were found, without exception, in both transplantation sites: “new islet organs” developed in the peritoneum, mainly in the spleen, liver, pancreas, small intestine, and omentum. Some of the capsule aggre-gates that evolved were embedded in the “guest organ”. Each microcapsule was surrounded with a dense net of capillaries (recipient vessels). Despite the normo-glycemia, only a few insulin-positive cells were present on the microcapsules. Every capsule maintained its original round, firm form and size. No broken, crushed or damaged microcapsules were observed. Partial islet cell regeneration was shown in 30% of the recipient-specific pancreata. This was more distinctive in the rats with long-term function than in those with short-term function of the graft. mpLI showed different degrees of fibrosis depending on the transplantation site and the function. The fibrosis was much stronger in the rats with short-term function of the graft; we attribute this to the lower vitality and purity of the graft. Fibroblasts encased the mpLI, but didn’t infiltrate the alginate. Fibrotic and non-fibrotic mpLI were repeatedly observed alongside each other even after long exposure in vivo. The reasons for this are unknown. The strong neovascularization of each and every mpLI was surprising; this was never observed in the empty microcapsules. The capillaries lay solely in the inner capsule on the periphery of the fibrotic ring. They did not infiltrate the ring or grow into the microcapsules. Therefore, we conclude that the mpLI stimulate the regeneration of the vessels and support the nutrition of the graft. Even after 502 days the immunohistochemical tests of the mpLI showed several insulin-positive beta cells, mainly single cells and smaller cell aggregates, few larger, intact cells. The immunohistochemical tests of the mpLI inner capsule showed cell infiltrates which were not seen in empty capsules and which were ob-viously activated by the microencapsulated cells: Infiltrates from CD4*, CD8+, ED1+, and HIS48+ cells were found more often in grafts with short-term function than in those with long-term function. Both graft types contained weak NK+ cell infiltrates but no TNF+ cells were observed. The cell infiltrates were more dis-tinctive in the grafts under the kidney capsules than in the grafts in the peritoneum. In our experimental STZ-diabetic rat model we were able to show that mpLI induce long-term normoglycemia, even without immunosuppression. Despite the effective prevention of acute rejection (by the alginate microcapsule), a slight specific and non-specific immune response to the foreign cells develops which must be further investi-gated. The quality and function of the porcine islets of Langerhans continues to im-prove so that we expect a much higher percentage of normoglycemic rats with long-term graft function in this model. All in all, the xITX appears to be a very promising method to replace the absent endocrine function of the pancreas on a long-term basis.