Set of five annual international awards, primarily established in 1895 by Alfred Nobel
POPULARITY
Categories
165 episodes with Nobel Prize
121 episodes with Nobel Prize
136 episodes with Nobel Prize
46 episodes with Nobel Prize
30 episodes with Nobel Prize
64 episodes with Nobel Prize
47 episodes with Nobel Prize
45 episodes with Nobel Prize
21 episodes with Nobel Prize
42 episodes with Nobel Prize
28 episodes with Nobel Prize
21 episodes with Nobel Prize
32 episodes with Nobel Prize
33 episodes with Nobel Prize
20 episodes with Nobel Prize
20 episodes with Nobel Prize
27 episodes with Nobel Prize
19 episodes with Nobel Prize
56 episodes with Nobel Prize
14 episodes with Nobel Prize
16 episodes with Nobel Prize
19 episodes with Nobel Prize
17 episodes with Nobel Prize
21 episodes with Nobel Prize
12 episodes with Nobel Prize
36 episodes with Nobel Prize
20 episodes with Nobel Prize
16 episodes with Nobel Prize
23 episodes with Nobel Prize
14 episodes with Nobel Prize
24 episodes with Nobel Prize
9 episodes with Nobel Prize
14 episodes with Nobel Prize
14 episodes with Nobel Prize
24 episodes with Nobel Prize
16 episodes with Nobel Prize
14 episodes with Nobel Prize
9 episodes with Nobel Prize
19 episodes with Nobel Prize
12 episodes with Nobel Prize
14 episodes with Nobel Prize
21 episodes with Nobel Prize
15 episodes with Nobel Prize
11 episodes with Nobel Prize
10 episodes with Nobel Prize
8 episodes with Nobel Prize
16 episodes with Nobel Prize
7 episodes with Nobel Prize
10 episodes with Nobel Prize
25 episodes with Nobel Prize
18 episodes with Nobel Prize
21 episodes with Nobel Prize
11 episodes with Nobel Prize
11 episodes with Nobel Prize
The Gilded Age has nothing on the present when it comes to a huge—and growing—portion of wealth being controlled by a smaller and smaller group of men—and they're doing their best to keep it that way. Must everything that goes up come down?Guest: Paul Krugman, Nobel Prize-winning economist and professor at City University of New York's Graduate Center.Want more What Next? Subscribe to Slate Plus to access ad-free listening to the whole What Next family and across all your favorite Slate podcasts. Subscribe today on Apple Podcasts by clicking “Try Free” at the top of our show page. Sign up now at slate.com/whatnextplus to get access wherever you listen.Podcast production by Rob Gunther, Evan Campbell, Madeline Thames-Ducharme and Patrick Fort.Paige Osburn is the senior supervising producer of What Next and What Next TBD. Hosted on Acast. See acast.com/privacy for more information.
Around 25 years ago, Ardem Patapoutian set out to investigate the fundamental biology behind our sense of touch. Through a long process of gene elimination, he identified a class of sensors in the cell membrane that turn physical pressure into an electrical signal. He changed the game in the field of sensation and perception, and in 2021 shared the Nobel Prize in Physiology or Medicine for his work. He joined Host Flora Lichtman in November 2025 to talk about his research, the odd jobs he worked along the way, and how he found a sense of belonging in science. Guests: Dr. Ardem Patapoutian is a professor and the Presidential Endowed Chair in Neurobiology at the Scripps Research Institute in La Jolla, California. Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Follow our show on Instagram, TikTok, Facebook, and Bluesky @scifri and sign up for our newsletters. Got a science question that's keeping you up at night? Call us: 877-472-4374 Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
The Gilded Age has nothing on the present when it comes to a huge—and growing—portion of wealth being controlled by a smaller and smaller group of men—and they're doing their best to keep it that way. Must everything that goes up come down?Guest: Paul Krugman, Nobel Prize-winning economist and professor at City University of New York's Graduate Center.Want more What Next? Subscribe to Slate Plus to access ad-free listening to the whole What Next family and across all your favorite Slate podcasts. Subscribe today on Apple Podcasts by clicking “Try Free” at the top of our show page. Sign up now at slate.com/whatnextplus to get access wherever you listen.Podcast production by Rob Gunther, Evan Campbell, Madeline Thames-Ducharme and Patrick Fort.Paige Osburn is the senior supervising producer of What Next and What Next TBD. Hosted on Acast. See acast.com/privacy for more information.
A Nobel laureate in economics argues the bans we pass to protect our morals are quietly killing people and the data backs him up. Why the line between a market we allow and one we forbid is mostly an accident of disgust. Subscribe if you want science with evidence, not speculation. My guest won the 2012 Nobel Prize for designing the systems that match kidney donors to patients who would otherwise die waiting. We cover why it's easy to buy heroin but hard to hire a hitman, what surrogacy bans actually do to the babies they're meant to protect, why paying kidney donors could end a shortage that kills thousands a year, and the trade-off statement he wants every lawmaker to say out loud. He has been called an organ trafficker. He explains why that's the point. What you'll hear: Why banning something that people want often makes it more dangerous The kidney market America won't build and what that silence costs What the hitman vs. heroin ban asymmetry tells us about effective prohibition The McCormick statement: the trade-off acknowledgment most policy debates refuse to make How prediction markets are eroding the boundary between public and private information Whether Milton Friedman was right to be embarrassed by the economics Nobel There's no such thing as a solution. There are only trade-offs. CHAPTERS 00:00 Who gets called an organ trafficker? 02:26 What makes a transaction repugnant? 03:14 Why bans without support create black markets 03:36 Heroin is easy. Hitmen are not. Why? 04:44 Prohibition, NASCAR, and moonshine 07:26 Surrogacy: legal here, criminal in Europe 12:30 When money turns something legal into a crime 14:28 Can religion corrupt a market? 15:56 Who actually pays for college? 21:38 The Enhanced Games: drugs as a marketing platform 25:30 Adderall, Erd0151s, and the science of getting sharper 30:58 Why AI makes market congestion worse before better 35:00 100,000 kidney failures a year. 30,000 transplants. 36:44 Portland decriminalized heroin. It failed. 39:22 The trade-off statement politicians refuse to make 41:14 Can you legalize sex work and shrink trafficking? 47:42 Kahneman chose to die. Who should decide? 48:30 Should we put GLP-1 drugs in the water? 56:12 America is the Saudi Arabia of blood plasma 01:00:54 Prediction markets and inside information 01:01:34 Sports gambling is more addictive than it looks 01:11:40 Peter Nobel called economics a marketing stunt 01:13:32 Is economics a real science? Get the transcript, fascinating bonus content, and my Monday M.A.G.I.C. Message: https://briankeating.com/yt Have a .edu email and live in the USA? You automatically win a meteorite: https://BrianKeating.com/edu Subscribe: https://www.youtube.com/DrBrianKeating?sub_confirmation=1 Support Into the Impossible on Patreon, get my weekly M.A.G.I.C. Message, unfiltered bonus content, and live monthly Office Hours with me: https://www.patreon.com/drbriankeating Join this channel for perks, monthly Office Hours, and your name in the Member Roster at the end of every episode: https://www.youtube.com/channel/UCmXH_moPhfkqCk6S3b9RWuw/join Get your three free gifts when you join my Multiverse of Minds: https://BrianKeating.com/cosmic Featured Guest: Alvin Roth website: https://web.stanford.edu/~alroth/ Moral Economics (book): https://www.amazon.com/Moral-Economics-Prostitution-Controversial-Transactions/dp/1541702018 My books: Losing the Nobel Prize (memoir): http://amzn.to/2sa5UpA Think Like a Nobel Prize Winner: https://a.co/d/03ezQFu Focus Like a Nobel Prize Winner: https://a.co/d/hi50U9U Galileo's Dialogue (first-ever audiobook): https://a.co/d/iZPi9Un Twitter/X: https://x.com/BrianKeating Substack: https://briankeating.substack.com Blog: https://briankeating.com/blog Audio-only: https://briankeating.com/podcast #intotheimpossible #briankeating #economics #NobelPrize #AlvinRoth #marketdesign #podcast Learn more about your ad choices. Visit megaphone.fm/adchoices
A skeptical reporter is sent to debunk England's most famous UFO hotspot — but the more nights he spends on Star Hill, the harder it becomes to dismiss what he sees, and the woman who keeps appearing there may be asking him to believe in far more than he ever bargained for.Look for this podcast on Apple Podcasts, Spotify, iHeart Radio, Amazon Music, Pandora, TuneIn Radio, and other podcast apps. Get a list of free listening apps here: https://weirddarkness.tiny.us/OTRCHAPTERS & TIME STAMPS (All Times Approximate)…00:00:00.000 = Show Open00:01:30.028 = CBS Radio Mystery Theater, “A Message From Space” (February 28, 1978) ***WD00:46:14.309 = The Sealed Book, “Death Spins a Web” (April 01, 1945) ***WD01:15:36.156 = The Shadow, “The Ghost Walks Again” (March 16, 1941) ***WD01:40:19.756 = Sleep No More, “To Build a Fire” and “Three Skeleton Key” (February 20, 1957) ***WD02:09:17.703 = BBC Radio 4 Spine Chillers, “Doppelganger” (January 01, 1977)02:34:22.138 = Strange, “Greenwood Acres” (October 10, 1955) ***WD02:46:54.981 = Suspense, “Defense Rests” (March 09, 1944) ***WD03:16:42.462 = Tales of the Frightened, “Mirror of Death” (November 27, 1957)03:21:37.453 = The Creaking Door, “Cards” (1964-1965) ***WD03:49:11.172 = The Saint, “Mr. Important” (October 15, 1947) ***WD04:17:00.318 = Theater 1030, “Trespassers Will be Experimented Upon” (1968-1971) ***WD04:45:47.834 = Tales From The Tomb, “Hooked” (1960s)04:50:01.149 = Show Close(ADU) = Air Date Unknown(LQ) = Low Quality***WD = Remastered, edited, or cleaned up by Weird Darkness to make the episode more listenable. Audio may not be pristine, but it will be better than the original file which may have been unusable or more difficult to hear without editing.CUSTOM WEBPAGE: https://weirddarkness.com/WDRR0701Tonight's #RetroRadio — Old Time Radio in the Dark brings together a full night of vintage horror, mystery, and supernatural suspense, from a UFO sighting on an English hillside to a steel hook left dangling from a car door.The CBS Radio Mystery Theater opens the night with "A Message From Space," written by Ian Martin and starring Tony Roberts, in which a skeptical American feature writer named Pete Heron is sent by his editor uncle to debunk the wave of UFO sightings around Warminster, England — an ancient stretch of Wiltshire ringed by 45,000-year-old burial mounds, or barrows, and crossed by invisible electromagnetic ley lines. Guided by a strange radio man called Bryce Bond up to Star Hill, Pete watches a glowing craft settle into a wheat field and leave behind a scorched, counterclockwise depression no wind could explain. But it's the violet-eyed woman named Maru who keeps appearing there — claiming to be a reporter, smelling of roses and lily of the valley, and seeming, somehow, entirely out of this world — who tests everything Pete thought he knew.From The Sealed Book comes "Death Spins a Web," a tale narrated from the pages of the keeper's ponderous volume about the dying Mrs. Oliver Drake, who summons her three worthless grandchildren — Blanche, Vivian, and the charming polo-playing scoundrel Chris — to her mansion and announces that her entire fortune will go to just one of them. As Chris courts both beautiful cousins at once to hedge his bets, a canoe trip across a deserted lake sets a deadly scheme in motion, and the old woman proves to be playing a far stranger game than anyone suspects.The Shadow presents "The Ghost Walks Again," with Lamont Cranston and Margot Lane traveling to a small New England town terrified by the apparition of Sir Roger Mathis, the village's stern Puritan founder, dead more than two hundred years. Townsfolk who favor opening the ancient meeting hall to the public keep turning up dead inside its torture stocks and presses, each victim clutching a death warrant signed in Sir Roger's own hand, and Cranston must determine whether a real ghost or a very human killer haunts the old colonial hall.Sleep No More, hosted by Nelson Olmstead with Ben Grauer, offers two literary terrors. First is Jack London's "To Build a Fire," the unforgettable Yukon tale of a confident, imaginationless newcomer — a chechaquo — who sets out alone across the frozen trail at seventy-five below zero with only a husky for company, ignoring an old-timer's warning never to travel alone in such cold. Second is George G. Toudouze's "Three Skeleton Key," the story of a lighthouse keeper stationed on a tiny rock twenty miles off the coast of Guiana, who watches a derelict three-master sail straight toward the light carrying a writhing, starving army of ship's rats that soon lay siege to the tower with three men trapped inside.BBC Radio 4's Spine Chillers delivers "Doppelganger," a modern psychological horror about Noah, a frazzled young assistant who keeps waking at exactly 3:44 a.m., drowning in FOMO and social-media envy as she frantically tries to be everywhere at once — her mother's birthday dinner, a girls' trip, an exclusive private members' club. When her doorbell camera records her leaving the apartment one night but never coming back, and a voice on the phone that sounds exactly like her own begins narrating her every move, the question becomes whether she's sleepwalking or being replaced.Strange, hosted by author and supernatural expert Walter Gibson, presents "Greenwood Acres," the account of Army Lieutenant Seth Proctor, who, on leave in a small backwater Georgia town in 1952, goes fishing among the water lilies and discovers a gleaming white plantation house that his landlady insists has been a crumbling ruin since a Civil War tragedy in 1865. There he meets a beautiful blonde woman named Laura swimming in the river, who somehow already knows his name — and whose own story is bound up with a jealous uncle named Cassius and a renegade Northern soldier.Suspense brings "Defense Rests," starring Alan Ladd as Robert Tasker, a young ex-convict and aspiring writer paroled into the law office of Max Krager, the only friend he's ever had, played by John McIntyre. When Krager's partner Arthur Hines — the very district attorney who once sent Tasker to San Quentin — turns up dead in his own office with Tasker's fingerprints on the paperweight beside him, the case looks open and shut, until a missing $50,000 and a switchboard girl named Peggy complicate everything.Tales of the Frightened tells "Mirror of Death," the brief, eerie story of Celeste Collins, a pretty Irish girl of twenty-one whose hand mirror shatters on the floor on the morning of her birthday — and who, despite dismissing the broken-mirror superstition as nonsense, receives a tall, gift-wrapped delivery that evening with a reflection waiting inside it.The Creaking Door, sponsored by State Express 555 cigarettes, presents "Cards," set at a charming English village fete where a devout vicar reluctantly agrees to have his fortune told with a pack of tarot cards by Mrs. Heyman. When she falls into a trance and warns him to fear death by fire, fear that which flies in the air but is not a bird, and fear the things of night — the bat, the wolf, and the leopard — the vicar plans to fly to Tanzania anyway to tour the mission stations funded by the fabulous Shelby Diamond fortune.The Saint stars Vincent Price as Simon Templar, the Robin Hood of Modern Crime, who refuses a five-thousand-dollar bribe to leave a corrupt town and instead hunts the unknown crime boss who gunned down his childhood friend, Treasury agent John Daniels. Following a trail of frightened informants — undertakers, a doomed dame named Rose Taylor, a bookkeeper named Al Boston, and a terrifying insect-obsessed killer called the Professor — Templar closes in on the one man whose name nobody dares speak.Theater 1030, a CBC Toronto production, offers "Trespassers Will Be Experimented Upon," a darkly comic supernatural tale by Anthony Lee Flanders about Nigel Hurdstrom, a winner of five Nobel Prizes, who drives his glamorous wife Vanessa across the Saskatchewan prairie toward a long-dreaded reunion. A storm strands them at the misty castle of the wicked Baron von Schenck — the mysterious figure who once taught a lonely farm boy everything the wind had to teach — and the pupil has come back to challenge his master, with a monstrous transplant machine waiting in the dungeon.Tales From The Tomb closes the night with "Hooked," the classic campfire legend of Ronnie and Cindy, two Jefferson High teenagers parked on a deserted road by the woods, who hear a radio bulletin about an escaped killer with a steel hook for a right hand just moments before a loud thud strikes the passenger side of the truck.
You already know something has changed - the energy crashes, the slow recovery, the brain fog that wasn't there ten years ago. Most people assume that's just aging. But it's NOT. Nobel Prize-winning research has identified a single molecule that controls how fast your body breaks down, and more importantly, exactly why yours is being destroyed faster than it's being rebuilt. The fix isn't complicated, but the order you do it in matters. In this video, Dave breaks down what this molecule is, why your body is actively working against it, and the exact protocol (diet, fasting, exercise, and supplementation) to restore it before the gap gets any wider.Thank you to our sponsors!Gatlan | Book your free consultation at www.gatlan.com/DAVEViome | Check it out at viome.com and use code 10DAVE for 10% off. It's time to stop guessing and start knowing your body.iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVETimestamps:0:00 – The Longevity Switch0:47 – Why Mitochondria Matter2:28 – What Mitophagy Is2:46 – How Mitophagy Works4:18 – What Shuts It Off8:54 – The Damage Compounds9:22 – How to Turn It Back On10:31 – Signal 1: Fasting11:48 – Signal 2: Exercise (REHIT)12:30 – Signal 3: Cold Exposure13:22 – Signal 4: NAD+14:29 – Signal 5: Urolithin A and SpermidineConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey's BEYOND Conference: https://beyondconference.com/Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
The Jack Carr Book Club June 2026 selection is THE LOST EMPIRE OF EMANUEL NOBEL by New York Times bestselling author Douglas Brunt. With the exception of the tsar, Emanuel Nobel was likely the wealthiest man in early 20th-century Russia, and one of the wealthiest in the world. Over three generations, he and his family grew the Russian petroleum industry into a behemoth that surpassed even John D. Rockefeller's Standard Oil. The Nobels imported best practices from America and improved on them, transforming every aspect of the industry. Though Emanuel's uncle Alfred would become world famous due to his creation of the Nobel Prize, the even more successful Nobels in Russia have been largely forgotten. The reason why is one of history's most gripping untold stories.Douglas Brunt is a New York Times bestselling author of THE MYSTERIOUS CASE OF RUDOLF DIESEL, host of the SiriusXM show Dedicated with Doug Brunt, and former cybersecurity executive. This conversation explores Doug's research, insights, and writing process behind THE LOST EMPIRE OF EMANUEL NOBEL.FOLLOW DOUGLAS BRUNTInstagram - @douglas_bruntX - @DougBruntFacebook - @dougbruntYouTube - @DedicatedwithDougWebsite - https://douglasbrunt-author.com/ FOLLOW JACK CARRInstagram - @JackCarrUSAX - @JackCarrUSAFacebook - @JackCarrYouTube - @JackCarrUSA Website - https://www.officialjackcarr.com/
NASA physicist's UAP math survives. His conclusion doesn't. Mayim Bialik ran the razor first — Brian finishes the cut. Kevin Knuth is a tenured physicist, former NASA Ames researcher, and published exoplanet scientist who has done the actual math on the Nimitz encounter. We cover: - Whether Tic Tac flight physics rules out conventional explanations - Why the 60% cross-cultural abduction pattern isn't what it looks like - The Malmstrom missile shutdowns and the three hypotheses Kevin ignores - What years of neutron analysis on alleged crash debris actually found - Why Mayim Bialik dismantled the light-day argument before Brian could. The inference move — not the data — is what fails the razor every time. Timestamps: 00:00 The cattle mutilation that started it all 01:59 What Kevin gets right — the steel man 07:14 Keating's Razor: how the cut works 11:13 Mayim catches the selection bias live 13:43 Malmstrom, the babies, and three hypotheses 15:00 The debris lab result that should change everything 19:18 The verdict: data survives, inference doesn't ———
>>> First, grab the guide I told you about in this episode: How to become a millionaire even on an average salary A few years ago we sold off some Tesla stock to pay off our second house. If you run the math on what that stock would be worth now, the result is honestly brutal. But I felt the Lord tell me clearly to do it. And looking back, I think I see exactly why He said what He said. In this episode Linda and I walk through five biblical investing secrets most Christians have completely missed: the verse Solomon wrote down 3,000 years before a man named Harry Markowitz won a Nobel Prize for the same idea, why God rebuked a servant in Matthew 25 for playing it too safe, the Bible verse that describes Warren Buffett's entire patient-compounding strategy, the move every wealth advisor still preaches that came straight from Joseph in Genesis 41, and the generational vision in Proverbs that reframes a lot of what most Americans get wrong about money and family. If you enjoyed this, we'd love to send you a free copy of our book — you just cover shipping. It has over 1,000 5-star reviews on Amazon. Grab it at seedtime.com/free. WHAT WE COVER IN THIS EPISODE Here's a little of what we cover in this episode: Why God rebuked a servant in the Bible for NOT investing (and most Christians have missed it) The investing principle Solomon wrote down 3,000 years before Wall Street figured it out Why "boring" is the actual investing strategy (and the lottery winner stat that proves it) The Bible verse that describes Warren Buffett's entire investing strategy The Joseph blueprint that every wealth advisor still preaches today The "vitamin K on day 8" principle that shows how specific God's instructions really are The Tesla stock decision Bob can't undo (and why he is at peace with it anyway) Why generational wealth without character is dangerous (and how to do it the other way) BIBLE VERSES MENTIONED Matthew 25 (Parable of the Talents) Luke 19:23 Ecclesiastes 11:2 Proverbs 13:11 Genesis 41 (Joseph and the seven years) Proverbs 13:22 RESOURCES MENTIONED 10x Investing (use code PODCAST for a discount) Grab the guide I told you about in this episode: (How to become a millionaire even on an average salary) DISCLAIMER Obligatory legal disclaimer: I'm a financial educator, not your financial advisor, investment advisor, tax pro, or lawyer. This channel is for general education, not personalized advice, and nothing here should be taken as a recommendation to buy, sell, or use any specific investment, account, or financial product. I'm just sharing what I'm doing, what I'm learning, and what I find interesting. Markets can be humbling. Investing involves risk, including the risk of losing money, and my results are personal, may not be typical, and are not guaranteed. Do your own research, use wisdom, and talk with a qualified professional before making financial decisions. Some links are to our resources and some are affiliate links, which means we may earn a commission at no extra cost to you. That helps keep the lights on around here, so thanks for the support.
Brian Keating is the Chancellor's Distinguished Professor of Physics in the Department of Physics at the University of California, San Diego, and the principal investigator of the Simons Observatory. He is a public speaker, inventor, and expert in the study of the universe's oldest light, the cosmic microwave background (CMB), using it to learn about the origin and evolution of the universe. Keating is also a writer, podcaster, and best-selling author of “Losing the Nobel Prize,” named one of Amazon Editors' “Best Nonfiction Books of All Time.” Shawn Ryan Show Sponsors: Head to https://superpower.com and use code SRS at checkout for $20 off your membership. Unlock your new health intelligence with 100+ biomarkers tested every year. Live better longer with BUBS Naturals. Get 20% OFF on collagen, MCT creamers, and more with code SHAWN at https://bubsnaturals.com/srs Right now, Babbel is offering listeners up to 60% off. Go to https://Babbel.com/SRS Go to get dot https://stash.com/SRS to see how you can receive $25 towards your first stock purchase and to view important disclosures. Search onX Offroad in the App Store or Google Play to access an off-road navigation app with trail maps, land boundaries, camping info, and offline capability. https://www.onxmaps.com/offroad/app Brian Keating Links: X - https://x.com/BrianKeating Instagram - https://instagram.com/DrBrianKeating Youtube - https://www.youtube.com/DrBrianKeating Website - htttps://BrianKeating.com/srs Learn more about your ad choices. Visit podcastchoices.com/adchoices
First up on the podcast, ScienceInsider editor Jocelyn Kaiser joins host Sarah Crespi to discuss big policy stories from the past month, including a proposal from President Donald Trump's administration to increase the involvement of politicians in grantmaking. Next on the show, Science Senior Editor Michael Funk joins to discuss a trio of papers on the light-detecting proteins responsible for color vision. Ohashi et al., Science 2026 Peng et al., Science 2026 Schmidt et al., Science 2026 Finally, in our books segment for this month, host Angela Saini talks with science writer Georgina Ferry, who wrote a biography about crystallographer Dorothy Crowfoot Hodgkin, the first and only woman scientist from the United Kingdom to win a Nobel Prize. This week's episode was produced with help from Podigy. About the Science Podcast Learn more about your ad choices. Visit megaphone.fm/adchoices
Many creation supporters are Christians that are also interested in ancient history and like to read about the latest archaeological discoveries. However, they are concerned when, say, some very ancient remains are carbon-14 dated at forty or even fifty thousand years old. According to the Bible, the Creation itself is no more than 10,000 years old, so how does the Bible-believing Christian handle this kind of information? To assure ourselves, we need to lift the cloak of secrecy about carbon-14 dating.Willard Libby developed the carbon-14 dating method in 1947. This was considered such a major breakthrough that he received the Nobel Prize a few years later. However, like every other method of measurement, the method itself had to be calibrated against things of historically dated and known age. Libby used wooden coffin lids and for the earliest dates was obliged to use historically dated material from Egypt. Libby reported in a footnote that the Egyptologist had confessed that Egyptian dating is “perhaps five centuries too old at five thousand years.” This one little foot-note reveals that if Egyptian dates were honestly brought forward by five hundred years, they would confirm the biblical Exodus. Secondly, any ages greater than about 5,000 years are beyond the range of historical calibration. The bottom line is that the carbon-14 method does have several serious and recognized problems beyond about 2,000 years.1 Corinthians 3:18“Let no man deceive himself. If any man among you seemeth to be wise in this world, let him become a fool, that he may be wise.”Prayer: Heavenly Father, I thank You that You are patient with us, especially when we read of discoveries and begin to doubt Your Word. Continue to teach me and give me understanding. In Jesus' Name. Amen.Image: Willard Frank Libby in Lab, CC BY-SA 4.0, Wikimedia Commons. To support this ministry financially, visit: https://www.oneplace.com/donate/1232/29?v=20251111
Stephen C. Meyer has a PhD from Cambridge in the philosophy of science, and he thinks AI just handed him his strongest argument yet. I spent years pushing back on him. Today I laid three traps. Watch what he does with the third one. Subscribe if you want science with evidence, not speculation. Meyer is a philosopher of science and director of the Center for Science and Culture at the Discovery Institute. His argument: every large language model is trained on text produced by conscious agents, and when you query its own outputs iteratively, it collapses into incoherence. That dependency, he says, is a tell. AI can recombine information. It cannot originate it. And that distinction points, in his view, to something minds do that matter alone cannot explain. I push back on all of it. We go after the Oklo reactor, a natural nuclear fission reactor that ran for millions of years in Africa two billion years ago with no human input whatsoever. I ask whether that breaks his information-from-mind argument. He sees the trap before I spring it, concedes the point where concession is honest, and explains exactly where the threshold lies. We also get into the Wheeler-DeWitt equation and Vilenkin's admission that quantum cosmology may require a mind predating the universe, the junk DNA prediction that Meyer's team made in the '90s before the ENCODE project confirmed it, and why beauty in physics can lead a field astray. What you'll hear: - Why model collapse is Meyer's strongest argument and where it has limits - The Oklo reactor trap and what Meyer's honest answer reveals about design detection - What Vilenkin actually said about a mind predating the universe - Whether intelligent design makes testable predictions or only retrodictions - The junk DNA call and what the ENCODE project found - Why beauty as a guide to physics has produced mathematical castles in the air Stephen Meyer thinks AI proves minds can't be reduced to matter. Is model collapse evidence of design, or is it just bad training data? CHAPTERS 00:00 The AI argument Meyer thinks no one can crack 00:44 What is inference to the best explanation? 05:52 AI has a tell: the model collapse problem 09:38 The Oklo trap: a natural nuclear reactor with no designer 11:56 Where the design inference becomes decisive and where it doesn't 15:50 Sean Carroll's wasteful universe problem and Meyer's answer 20:00 Where did atheist scientists get access to the mind of God? 23:22 The fine-tuning of the periodic table: why are there only 500 stable nuclei? 25:52 The universe had a beginning: observational astronomy and the Borde-Guth-Vilenkin theorem 27:40 Quantum cosmology: how math alone is supposed to birth a universe 29:08 Vilenkin's question: are we saying a mind predates the physical universe? 34:06 Mathematical castles in the air: where beauty in physics goes wrong 40:00 Does intelligent design make predictions or only retrodictions? 43:52 The junk DNA prediction and what ENCODE found 46:30 James Tour, origin of life, and the hidden hand of the investigator 51:56 God-of-the-gaps vs. inference to the best explanation 56:02 The Story of Everything: where to watch and what to expect Get the transcript, fascinating bonus content, and my Monday M.A.G.I.C. Message: https://briankeating.com/yt Have a .edu email and live in the USA? You automatically win a meteorite: https://BrianKeating.com/edu Subscribe: https://www.youtube.com/DrBrianKeating?sub_confirmation=1 Support Into the Impossible on Patreon, get my weekly M.A.G.I.C. Message, unfiltered bonus content, and live monthly Office Hours with me: https://www.patreon.com/drbriankeating Join this channel for perks, monthly Office Hours, and your name in the Member Roster at the end of every episode: https://www.youtube.com/channel/UCmXH_moPhfkqCk6S3b9RWuw/join Featured Guest: Stephen C. Meyer website: https://stephencmeyer.org/ The Story of Everything (film, Amazon Prime June 25): https://www.primevideo.com/detail/0NO974XWBQQNYH9TB4ESIJIVL9 Signature in the Cell (book): https://signatureinthecell.com/ Return of the God Hypothesis (book): https://returnofthegodhypothesis.com/ My books: Losing the Nobel Prize (memoir): http://amzn.to/2sa5UpA Think Like a Nobel Prize Winner: https://a.co/d/03ezQFu Focus Like a Nobel Prize Winner: https://a.co/d/hi50U9U Galileo's Dialogue (first-ever audiobook): https://a.co/d/iZPi9Un Twitter/X: https://x.com/BrianKeating Substack: https://briankeating.substack.com Blog: https://briankeating.com/blog Audio-only: https://briankeating.com/podcast #intotheimpossible #briankeating #intelligentdesign #artificialintelligence #cosmology #podcast #StephenMeyer #philosophy Learn more about your ad choices. Visit megaphone.fm/adchoices
rWotD Episode 3335: Aldous Huxley Welcome to random Wiki of the Day, your journey through Wikipedia's vast and varied content, one random article at a time.The random article for Sunday, 21 June 2026, is Aldous Huxley.Aldous Leonard Huxley ( AWL-dəs; 26 July 1894 – 22 November 1963) was an English writer and philosopher. His bibliography spans nearly 50 books, including non-fiction works, as well as essays, narratives and poems.Born into the prominent Huxley family, he graduated from Balliol College, Oxford, with a degree in English literature. Early in his career, he published short stories and poetry and edited the literary magazine Oxford Poetry, before going on to publish novels (witty social-satirical novels and grimly serious ones), travel writing, and screenplays. He spent the latter part of his life in the United States, living in Los Angeles from 1937 until his death. By the end of his life, Huxley was widely acknowledged as one of the foremost intellectuals of his time. He was nominated for the Nobel Prize in Literature nine times, and was elected Companion of Literature by the Royal Society of Literature in 1962.Huxley was a pacifist. He grew interested in philosophical mysticism, as well as universalism, addressing these subjects in his works such as The Perennial Philosophy (1945), which illustrates commonalities between Western and Eastern mysticism, and The Doors of Perception (1954), which interprets his own psychedelic experience with mescaline. In his most famous novel, Brave New World (1932), and his final novel, Island (1962), he presented his visions of dystopia and utopia, respectively.This recording reflects the Wikipedia text as of 00:24 UTC on Sunday, 21 June 2026.For the full current version of the article, see Aldous Huxley on Wikipedia.This podcast uses content from Wikipedia under the Creative Commons Attribution-ShareAlike License.Visit our archives at wikioftheday.com and subscribe to stay updated on new episodes.Follow us on Bluesky at @wikioftheday.com.Also check out Curmudgeon's Corner, a current events podcast.Until next time, I'm standard Brian.
One Indian's vote is worth 2.5 times another Indian's vote. According to Professor Gautam Desiraju, that single fact reveals a deep flaw in Indian democracy—and fixing it could require redrawing the map of India itself. Most Indians have never heard the word delimitation. Yet Professor Desiraju argues it may be the most important political issue India will face in the coming decade. He believes India should not have 28 states, but closer to 75. He argues that every vote must carry equal value. He questions whether the Constitution should be treated as a sacred document. And he makes the case for reforms that could fundamentally reshape how India is governed. Professor Gautam Desiraju is one of India's most distinguished scientists and a recipient of the Ewald Prize, often called the Nobel Prize of Crystallography. In recent years, however, he has turned his attention to a different question: How should India govern itself in the 21st century? In this conversation with Roshan Cariappa on Bharatvaarta, Professor Desiraju explains why delimitation, state reorganization, constitutional reform, representation, and governance are all interconnected—and why India may need to rethink some of its deepest political assumptions. This is a conversation about democracy, federalism, representation, and the future of Bharat. What We Cover * Why India should have 75 states * Why some Indian votes are worth more than others * The principle of “One Vote, One Value” * Why smaller states strengthen democracy * The case for delimitation * Why India's MPs represent too many people * The “missing middle” in Indian democracy * Why young Indians feel disconnected from politics * First-Past-The-Post vs Proportional Representation * Why the Constitution is not a holy book * The case for a new Constituent Assembly * Ambedkar's views on state reorganization * Why India may need 2,000 MPs * The future of Indian democracy ⏱️ TIMESTAMPS 00:00 One Indian's Vote Is Worth 2.5x Another's 01:04 Introduction: Why India Needs 75 States 02:02 The Case For 75 States & Stronger Democracy 21:04 Why India's States Are Too Unequal In Size 22:31 The Problem Of Political “Heft” & Representation 23:24 How 75 States Would Actually Work 24:43 Why MPs Have Become Too Distant From Citizens 26:33 Why Delimitation Must Happen Now 26:59 Why Young Indians Feel Disconnected From Politics 27:21 India's Missing Middle Problem 32:14 The Growing Disconnect Between Citizens & Government 33:45 Why First-Past-The-Post Is Failing India 46:45 Breaking Karnataka Into Seven States 47:51 Ambedkar On Language, States & Federalism 48:44 “The Constitution Is Not A Holy Book” 50:27 Why 105 Amendments Signal A Bigger Problem 52:18 Why India Needs A New Constituent Assembly 53:56 Constitution vs Civilizational State 55:05 Why Delimitation Was Delayed For 50 Years 56:31 Why India Needs 2,000 MPs 01:00:29 Redrawing Bengal: A Practical Example 01:14:20 Why Vajpayee Wanted More States 01:15:00 Reforming India's Bureaucracy
AI Unraveled: Latest AI News & Trends, Master GPT, Gemini, Generative AI, LLMs, Prompting, GPT Store
New York is the latest state to legalize medical aid in dying. Stephen Dubner speaks with the governor who signed the law, a Nobel Prize-winning economist, a death doula — and an ethicist who thinks the very idea is wrong. SOURCES: Kathy Hochul, governor of New York. Suzanne O'Brien, death doula, founder of Doulagivers Institute. Al Roth, economist at Stanford University. Daniel Sulmasy, physician, philosopher, director of the Kennedy Institute of Ethics at Georgetown University. RESOURCES: Moral Economics: From Prostitution to Organ Sales, What Controversial Transactions Reveal About How Markets Work, by Al Roth (2026). "New York Moves to Allow Terminally Ill People to Die on Their Own Terms," by Grace Ashford (New York Times, 2025). The Good Death: A Guide for Supporting Your Loved One through the End of Life, by Suzanne O'Brien (2025). The Future of Assisted Suicide and Euthanasia, by Neil Gorsuch (2009). EXTRAS: "Make Me a Match (Update)," by Freakonomics Radio (2023). Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
I wore the Leela Quantum necklace for months before recording this episode because I wanted to experience it day to day before sharing it with you. I took it to California and had a really interesting experience with my daughter that I'll tell you about in this interview with Todd Shipman, a wellness entrepreneur who came into this space as a skeptic and stayed because of what he found. We explore what "quantum energy" actually means, what EMFs from your phone, car, and AirPods may be doing to your body, and how to stay both open-minded and discerning. I ask the questions you'd want answered.What you'll learn:Whether "quantum energy" is woo-woo or actually rooted in real physics (and what the 2022 Nobel Prize did and didn't prove)Why some people wonder whether everyday EMF from phones, cars, and AirPods affects how they feel, and what the open questions areWhat Todd says his company's own testing looks at, like HRV.How sleep and brain fog in perimenopause relate to the nervous system, as general educationThe honest questions to ask before you spend money on any "energy" wellness productChapters:0:00 Is Quantum Energy Woo Woo? Why This Isn't What You Think3:04 Meet Todd Shipman + What Quantum Energy Actually Means7:08 The 2022 Nobel Prize, Entanglement & Why He Tried to Debunk It10:17 EMF and How You Might Feel: Sleep, Stress & the Questions to Ask16:06 The Tesla Headache Story: My Daughter and the Necklace24:12 Food Sensitivities, Structured Water & the Claims to Question32:54 Inside the Necklace: Brass, Titanium Spheres & Frequency Recipes42:24 Bloating, Digestion, Sleep & Wearing It Every Day51:43 Where to Start, the Discount & Final ThoughtsLearn more about Leela Quantum.A quick note: this is an education-first conversation, not medical advice. Todd is sharing his company's research and personal experience—nothing here is intended to diagnose, treat, or prevent any condition. If you have a serious health condition or a food allergy, always work with your doctor and never substitute any wellness product for medical care or your EpiPen.Send us Fan Mail ======Morphus: Menopause Reimagined
Get your Myoscience Fasting Berberine Accelerator here: https://bit.ly/4aVZxcl Pre-order Keto Flex Revised and get free bonuses at: https://bit.ly/4wKG1sM 7 Levels of Fasting Nobody Talks About, Including the One That Starves Cancer Cells There are seven levels of fasting, and most people never get past level two. Ben breaks down each level, what organ it heals, and why most fasting advice stops way too early to unlock the real benefits. From the 12 hour fast that frees up your pancreas, to the 16 hour fast that triggers autophagy (the Nobel Prize winning process where your cells clean out their own junk), to the 24 hour fast that flips your liver into fat burning mode, Ben walks through the science level by level. Then things get interesting. At 36 hours, inflammation markers drop and the immune system starts clearing out dysfunctional cells. At 48 to 72 hours, growth hormone floods the body, up to 2,000% in men, to protect muscle while burning fat. And at 5 days, the metabolic environment shifts into one that researchers have shown cancer cells cannot survive in. Key takeaways: 16 hours triggers autophagy, the cellular cleanup process that won a Nobel Prize in 2016 24 hours flips your liver from sugar burning to fat burning, producing ketones that can boost mitochondrial energy by up to 400% 36 hours drops inflammation markers and triggers an immune system reset 48 to 72 hours floods the body with growth hormone (up to 2,000% in men) to protect muscle while burning fat A 2019 German study followed 1,422 patients fasting 4 to 21 days, with 84% reporting health improvements and under 1% adverse effects 5 day fasts create a metabolic environment, backed by USC research and a 2022 Cancer Discovery paper, that cancer cells cannot survive in 7 days shifts something psychological: you realize you were never as hungry as you thought Research and names referenced: Dr. Valter Longo (USC), Yoshinori Ohsumi (2016 Nobel Prize), Otto Warburg, Buchinger Wilhelmi Clinic (PLOS One, 2019), Intermountain Medical Center growth hormone study. Find All The Ben Azadi Show Sponsorship Deals https://www.ketokamp.com/sponsorship-deals Learn more about your ad choices. Visit megaphone.fm/adchoices
When Demis Hassabis pitched DeepMind to a few venture capitalists back in 2010, the business plan was almost comically audacious. “Step one: Solve intelligence. Step two: Use it to solve everything else,” he recalls in a conversation at Stanford Graduate School of Business with Stanford University President Jonathan Levin. “And people were quite confused. But we really meant it.”Sixteen years later, the “broad arcs” of that plan have gone “unbelievably well,” says Hassabis, a chess prodigy turned video game developer turned neuroscientist turned Nobel Prize-winning AI pioneer. Today he's on a mission to create “the ultimate tool for science,” building on his decision to give away AlphaFold, the groundbreaking AI system that predicts the structures of proteins. The future, Hassabis says, is just around the corner: “Ten years from now, I think we'll realize that we were standing in the foothills of the singularity now.”AI@GSB, the Dean's Applied AI initiative at the Stanford Graduate School of Business (GSB), and Stanford Medical School hosted a conversation with Demis Hassabis, Co-founder and CEO of Google DeepMind, on the frontier of artificial intelligence and what it means for how we live, work, and flourish.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Episode Highlights With ToddWhat quantum energy actually is and how Todd went from skeptic to deep understanding How this term gets misused a lot and the important things to actually understandWhat quantum entanglement is and how this can benefit us practically The 2022 Nobel Prize in Physics was awarded to Zellinger, Clauser and Aspect for proving quantum entanglement, but how it actually worksHow they do experiments at a distance on HRV and how they can see results remotely and rapidly Why quantum energy is neutralizing energy and doesn't need to add anything but neutralizes disruptive energy- and their experiments with this and neutralizing EMFs effects on the bodyQuantum upgrade vs leela quantum physical products and how they work the same and differentlyWhy Katie is running Quantum Upgrade on her podcast recording room and has the Blocs in her wellness center and homeHow they saw a 10% increase in HRV with quantum upgrade They see an increase in wound healing and ATP productionDr. Dru covered a study they did on 5G and what it does to the brain and HRV- improving alpha brain waves and reducing beta and gamma, which is measurableResources Mentioned Quantum Upgrade free trial - 15-day FREE trial, no credit card required with code WELLNESSMAMA15LeelaQHiyaHiya created a super powered chewable vitamin for kids that packs twelve organic fruits and vegetables plus fifteen essential vitamins and minerals into every dose. Try it at hiyahealth.com/wellnessmama for 50% off your first order.
What do the best teams do differently? It's a question that's at the heart of a new book by social psychologist Ron Friedman. In "Superteams," Friedman explains what the research says about the most successful teams. Spoiler alert: those teams aren't the ones that collaborate the most, get along best, or have fancy office perks. The best teams, as Friedman writes, balance collaboration with focused individual work, phase out useless meetings, and reduce burnout — all while increasing productivity. Friedman joins us for the hour to discuss what we can learn from the "Succession" writers' room, ABBA's recording studio, and the labs of Nobel Prize-winning scientists. In studio:Ron Friedman, Ph.D., author of "Superteams: The Science and Secrets of High-Performing Teams"---Connections is supported by listeners like you. Head to our donation page to become a WXXI member today, support the show, and help us close the gap created by the rescission of federal funding.---Connections airs every weekday from noon-2 p.m. Join the conversation with questions or comments by phone at 1-844-295-TALK (8255) or 585-263-9994, email, Facebook or Twitter. Connections is also livestreamed on the WXXI News YouTube channel each day. You can watch live or access previous episodes here.---Do you have a story that needs to be shared? Pitch your story to Connections.
In this special live episode of Facts vs Feelings from Carson's Second Quarter Summit in Chicago, Ryan Detrick and Sonu Varghese sit down with Nobel Prize-winning economist Dr. Richard Thaler for a conversation that ranges from NFL draft strategy to retirement savings design to why markets keep producing events that are statistically supposed to be impossible.Thaler breaks down his "Loser's Curse" research on the NFL draft, explaining why top picks are systematically overvalued and why trading down is almost always the smarter move. Twenty years and a Nobel Prize later, teams have barely improved their ability to predict talent. The better-than-the-next-guy stat went from 52% to 53%.The conversation covers Bob Shiller's work on excess market volatility, what it actually means when 10-sigma events keep showing up every decade, and why the coming wave of major IPOs is forcing index providers into decisions that are anything but passive.On the behavioral side, Thaler walks through the three pillars that transformed 401k design: automatic enrollment, target date funds, and Save More Tomorrow and why the UK's approach to retirement mandates got the balance right. He also gets into mental accounting and why a $2 million gain in home equity has almost no impact on spending while a direct deposit hits a checking account and disappears immediately.Key Takeaways: NFL teams have had 20 years, full quant departments, and AI-powered scouting to improve on Richard Thaler's draft research. Their ability to rank players better than a coin flip moved from 52% to 53%. Tom Brady was picked 199.The first pick in the NFL draft is not worth six second-round picks. Trading down is the winning strategy, and trading a pick this year for a pick next year where the going rate is one round works out to roughly a 120% implied interest rate.When stocks get added to the S&P 500, the price pops. Andre Shleifer proved it in grad school with a paper called "Do Demand Curves Slope Down for Stocks?" The answer was yes, and it was controversial at the time. Now everyone knows it and the SpaceX IPO is about to test it at a scale the market has never seen.Buying an IPO on day one looks exciting and has historically cost investors around 30% in underperformance versus the market over the following three years, according to Jay Ritter's data.Making enrollment the default in 401k plans, rather than requiring employees to opt in, had a bigger impact on retirement savings rates than any amount of financial education. Which box comes pre-checked should be irrelevant. It isn't.A $2 million gain in home equity produces almost zero change in spending. The same money landing in a checking account gets spent. Mental accounting is not a quirk; it shapes how wealth actually moves through the economy, and you can't model the wealth effect without accounting for where the money sits.Jump to:0:00 - Live From Chicago Kickoff0:35 - Sponsor Message From Pimco1:13 - Welcoming Nobel Laureate Richard Thaler2:31 - The NFL Draft Loser's Curse9:03 - Can You Fire Your Team10:31 - Why Markets Swing Too Much18:35 - IPOs Index Rules And Demand Shocks24:24 - Live T-Shirt Toss Intermission25:47 - Nudges That Fix Retirement Saving34:33 - Education Versus Mandates In Policy38:45 - Fees Transparency And Trust41:09 - Mental Accounting And The Wealth Effect45:13 - Final Thanks And Sign-Off45:42 - Important DisclosuresConnect with Ryan:• LinkedIn: https://www.linkedin.com/in/ryandetrick/• X: https://x.com/RyanDetrickConnect with Sonu:• LinkedIn: https://www.linkedin.com/in/sonu-varghese-phd/• X: https://x.com/sonusvarghese?lang=enQuestions about the show? We'd love to hear from you! factsvsfeelings@carsongroup.com
A bioluminescent jellyfish brought a rainbow of possibilities to biology. Aarati tells the story of a brilliant chemist who won the Nobel Prize for transforming nature's fluorescent proteins into powerful tools for modern science. Support the showFor more information and sources for this episode, visit https://www.smartteapodcast.com.
Douglas Brunt returns to Totally Booked to discuss THE LOST EMPIRE OF EMANUEL NOBEL, the fascinating true story of the Nobel family's rise in imperial Russia, their pivotal role in the global oil industry, and the revolutionary forces that reshaped the twentieth century. From the origins of the Nobel Prize to the rise of Stalin and the fall of the Romanovs, Brunt shares how he uncovered this forgotten family saga—and why its lessons about power, energy, and history still resonate today.Bestselling author Ben Mezrich discusses CHECKMATE, his gripping deep dive into the biggest cheating scandal in chess history. From a shocking showdown between world champion Magnus Carlsen and controversial young challenger Hans Niemann to questions about AI, truth, and the future of competition, Mezrich unpacks the real-life drama behind a story that reads like a thriller. He also shares his unique approach to turning headline-making nonfiction into blockbuster books and films.** If you enjoy recommending things you love and even earning from it, you have to become a creator on ShopMy! You'll be able to see that your recommendations matter. Click my referral code here to learn more! ***** Want another secret podcast? If you sign up for my Z.I.P. Membership program, you'll get access to an exclusive podcast called Zibby's Show Notes, the behind-the-scenes of everything! Head to zibbyowens.com/subscribe to sign up. Hosted on Acast. See acast.com/privacy for more information.
Send us Fan MailIf you enjoyed this deep dive on cloning and genetic modification, hit subscribe, drop a comment with your take — should we bring back the woolly mammoth? — and share the episode with the friend who still thinks Walt Disney's head is in a freezer.Cloning and genetic modification get blended together constantly in pop culture, so this episode breaks down what's actually real, what's a myth, and how we got from a frog tadpole in 1952 to dire wolf pups in 2025.Brian, Thomas, and producer Corey (it's Corey's birthday) walk through the full history and science of cloning — admitting up front they're not scientists, just three guys following a rabbit hole that started with a family cloning their dog, CRISPR edits, and the Lone Star tick. From there it turns into a surprisingly thorough tour of how copying and editing life actually works.The episode untangles the four ideas people constantly confuse: cloning (a genetic copy, same DNA), genetic modification / gene editing (changing genes, like CRISPR), de-extinction (reviving a lost species), and chimeras (mixing cells from two species). With that foundation set, the crew traces the timeline from Yves Delage's 1895 nuclear transplantation concept and Hans Spemann's 1938 "fantastical experiment," through the first nuclear transfer in 1952, John Gurdon's Nobel Prize work, and Dolly the sheep — the first mammal cloned from an adult cell, born July 5, 1996.If you've ever wondered whether you can really clone your pet, this one answers it: it's real, it's commercial, and it's expensive. They cover the actual companies and price tags, why a clone is not a resurrection, and why the Humane Society pushes back on the practice. The conversation also gets into man-animal hybrids — the bizarre real story of Soviet scientist Ilya Ivanov — and busts the myth that Stalin wanted an army of ape-man super soldiers.This is for anyone curious about CRISPR, stem cell medicine, de-extinction headlines, and the ethics underneath all of it: human-animal chimeras grown for transplant organs, the 100,000+ Americans on the organ waiting list, and whether reproductive human cloning should stay banned. Expect the science (telomeres, Large Offspring Syndrome, the brutal 1–5% survival rate) alongside the kind of unfiltered, off-the-rails commentary the show is known for.By the end you'll understand why the 2025 "dire wolf" isn't really a dire wolf, what the Bucardo's grim record actually was, and why mules — and ligers — can't be bred the way you'd think. It's a fast, funny, fact-checked crash course in one of the wildest fields in modern science.New episodes of The Days Grimm Podcast drop regularly — history, science, true crime, and whatever rabbit hole Tom drags everyone into next.TIMELINE:00:00 — Cold open & welcome (Corey's birthday)01:58 — Today's deep dive: cloning and genetic modification02:07 — "We're not scientists" disclaimer03:04 — Why Tom picked this: CRISPR, the Lone Star tick & a cloned dog04:34 — 1895: the first nuclear transplantation concept06:21 — The 4 things people confuse: cloning, gene editing, de-extinction & chimeras07:07 — Why the 2025 "dire wolf" is really edited gray wolf11:16 — 1952 leopard frogs & John Gurdon's Nobel work12:30 — Dolly the sheep and why she mattered14:00 — Why mules (and ligers) can't reproduce16:46 — How cloning actually works (somatic cell nuclear transfer)20:26 — What we've cloned so far + first primate clones (2018)21:54 — Can you clone your pet? The real companies and prices23:51 — A clone is not a resurrection + welfare concerns25:01 — Man-animal hybrids & the Soviet Ivanov story27:00 — Chimeras for medicine and pig organ transplants32:00 — De-extinction & the Bucardo: "extinct twice"33:47 — The black-footed ferret success story34:30 — 2025 dire wolf pups & the woolly mouse37:00 — Telomeres, Large Offspring Syndrome & failure rates39:30 — Ethics: mammoths, pets, chimeras & human cloning41:00 — Busting the Walt Disney frozen-head myth42:30 — Wrap-up[The Days Grimm Podcast Links]- YouTube: https://www.youtube.com/c/TheDaysGrimm- Our link tree: linktr.ee/Thedaysgrimm- GoFundMe account for The Days Grimm: https://gofund.me/02527e7c [The Days Grimm is brought to you by]Sadness & ADHD (non-medicated)
Roman Yampolskiy has spent two decades trying to prove that superintelligent AI can be controlled. He couldn't. I invited him on to make his case. Subscribe if you want science with evidence, not speculation. Roman is a professor of computer science at the University of Louisville and one of the earliest researchers in AI safety. His book AI: Unexplainable, Unpredictable, Uncontrollable started as an attempt to solve the alignment problem. After decades of work, it became a proof that the problem cannot be solved. Not difficult. Mathematically impossible. I push back hard. We go after the Einstein test: can a large language model trained only on pre-1911 physics reproduce what Einstein did with the same data? We ran that experiment. It failed. Roman and I disagree about what that means. We also get into the halting problem and what it actually tells us about predicting smarter-than-human behavior, whether value alignment is a real problem or a well-funded category error, the case for a government moratorium on frontier model development, and why Roman thinks giving an AI agent access to your computer is the dumbest thing a smart person can do. What you'll hear: Whether AI control is mathematically impossible or just unsolved Why Roman thinks all current AI safety work is security theater What the halting problem actually means for superintelligence The alignment problem: real issue or well-funded category error Why Roman wants a moratorium on frontier model development What to tell your kids about careers in a world where Roman might be right If you listen to other people, the best you can become is average. CHAPTERS 00:00 Creating a mind without an off switch 01:34 Solving problems beyond our own intelligence 04:08 Einstein's epiphany and the limit of AI intuition 08:18 Assessing the Einstein test: Why the experiment failed 12:22 Path dependency: Are LLMs and GPUs our QWERTY? 16:10 The barriers preventing AI from solving physics 21:54 Safety vs. Capability: Why toddlers are safe but teens are not 23:06 The halting problem: Predicting agents smarter than us 25:58 The impossibility of a system proving its own integrity 28:18 Regulation: Genuine safety or a gift to oligarchs? 33:28 Is human cognition non-computable? Penrose vs. the field 39:00 Ethical duties: Must we treat AI with humanity? 43:00 From internet memes to monsters: Decoding the book cover 46:22 Customized realities: Can everyone have their perfect world? 49:50 Von Neumann probes and the panspermia hypothesis 55:02 Categorizing AI: The one version that should terrify you 58:22 Pause AI: The movement for a development moratorium 59:58 Career advice for kids in a post-professional world 01:07:58 Cross-examining Sam Altman 01:15:48 Roman's dream debate 01:19:50 Lessons for a younger self Substack: https://briankeating.substack.com Get the transcript, fascinating bonus content, and my Monday M.A.G.I.C. Message: https://briankeating.com/yt Have a .edu email and live in the USA? You automatically win a meteorite: https://BrianKeating.com/edu Subscribe: https://www.youtube.com/DrBrianKeating?sub_confirmation=1 Support Into the Impossible on Patreon, get my weekly M.A.G.I.C. Message, unfiltered bonus content, and live monthly Office Hours with me: https://www.patreon.com/drbriankeating Join this channel for perks, monthly Office Hours, and your name in the Member Roster at the end of every episode: https://www.youtube.com/channel/UCmXH_moPhfkqCk6S3b9RWuw/join Featured Guest: Roman Yampolskiy on Twitter/X: https://x.com/romanyam?lang=en AI: Unexplainable, Unpredictable, Uncontrollable: https://www.romanyampolskiy.com/books/ My books: Losing the Nobel Prize (memoir): http://amzn.to/2sa5UpA Think Like a Nobel Prize Winner: https://a.co/d/03ezQFu Focus Like a Nobel Prize Winner: https://a.co/d/hi50U9U Galileo's Dialogue (first-ever audiobook): https://a.co/d/iZPi9Un Twitter/X: https://x.com/BrianKeating Substack: https://briankeating.substack.com Blog: https://briankeating.com/blog Audio-only: https://briankeating.com/podcast #intotheimpossible #briankeating #AIrisk #artificialintelligence #aisafety #podcast #superintelligence #RomanYampolskiy Learn more about your ad choices. Visit megaphone.fm/adchoices
Physicist fact-checks Michio Kaku's biggest claims — quantum collapse of capitalism, Theory of Everything, black hole gateways. Does celebrity physics do more damage than good? Brian Keating breaks down Michio Kaku's viral @TheDiaryOfACEO "World-Renowned Physicist: They Are Lying To You About UFOs & Reality - Michio Kaku" https://youtu.be/opB7_JXL0LA?si=RzVyEgwKtQRzs9Ao I fact-check everything from quantum computing to black holes to the multiverse. Why quantum computers won't kill capitalism overnight String theory: candidate framework or confirmed Theory of Everything? "Read the mind of God" — Einstein's phrase or Hawking's? Tabby Star: aliens vs. dust, and why Kaku buries the retreat Black holes as gateways, wormholes as cousins of black holes, and what spaghettification actually rules out Celebrity physicists who present speculation as settled science set back the field more than any funding cut. CHAPTERS 00:00 Quantum computers and capitalism collapse 01:23 What quantum computing actually can and can't do 03:39 String theory and the Theory of Everything 06:16 Who really said "read the mind of God" 09:40 Tabby Star: aliens or something boring? 13:45 11 dimensions: prediction or math requirement? 18:19 Is dark matter made of string vibrations? 23:03 The multiverse bubble bath — poetry or physics? 28:39 Wormholes vs. black holes: not very similar 34:22 Simulation theory and Kaku's "Option Four" 37:37 Verdict: great communicator, bad epistemics ———
This Is Not About Running: Highlighting Abuse In Youth Sports When youth running prodigy Mary Cain was scouted by top universities in the eighth grade, she thought she was chasing her athletic dreams – but the reality of the elite sports pipeline would cost her far more than she ever imagined. This week she pulls back the curtain on the toxic culture of high-stakes youth athletics, detailing how top-tier programs often exploit young prodigies. Guest: Mary Cain, author, This Is Not About Running Before The World Forgot: A Look At The Women Who've Advanced Society Throughout history, the female trailblazers who have made monumental achievements in science, literature, and innovation have been systemically minimized or forgotten. Our guests this week discuss how societal biases erased women's intellectual contributions and why recognizing these female geniuses is essential to completing our understanding of human progress. Guests: Janice Kaplan, author, The Genius of Women Catherine Whitlock, author, Ten Women Who Changed Science and the World Facebook: ingoodhealthpodX: @ ingoodhealthpodIG: @ingoodhealthpodYouTube: @ingoodhealthpodSpotify Apple Podcast In Good Health PodcastSubscribed to the newsletterFull ArchiveContact UsBecome an Affiliate Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
394 - Long before his Nobel Prize, William Faulkner published his FIRST short story, a wild one! Tuck in for an early aviation thriller as a young pilot and pure luck collide in the story that started it all.
Listen to today's podcast... Today is a world-wide celebration to honour and thank those people who donate their blood without any reward, except the knowledge that they have helped to save lives. This day has particular significance as it is the birthday of Karl Landsteiner, the Nobel Prize winner who discovered the ABO blood group system. Take One Action Today To Build Your #Resiliency! So Here are today's Tips For Building Resiliency and Celebrating Blood Donor Day: Get others involved and it makes it easier to remember to donate, and less anxious for those who have never gone before. Get your office or organization involved and promote it through your on-line or internal communications Get your family involved – go together and make it a family-giving project Be a role model for others – I love how my mom still goes regularly to donate. With our lives being so busy it is easy to forget to do this simple little act of kindness. But this little act can mean the difference between life and death. Remember, If you like today's wellness tips, let me know. You can leave me a review on amazon or through your #alexa app. Looking for more ways to build your resiliency? Take my free on-line resiliency test at worksmartlivesmart.com under the resources and courses tab. #mentalhealth #hr
Before The World Forgot: A Look At The Women Who've Advanced Society Throughout history, the female trailblazers who have made monumental achievements in science, literature, and innovation have been systemically minimized or forgotten. Our guests this week discuss how societal biases erased women's intellectual contributions and why recognizing these female geniuses is essential to completing our understanding of human progress. Guests: Janice Kaplan, author, The Genius of Women Catherine Whitlock, author, Ten Women Who Changed Science and the World Host: Greg Johnson Producer: Polly Hansen Facebook: ingoodhealthpodX: @ ingoodhealthpodIG: @ingoodhealthpodYouTube: @ingoodhealthpodSpotify Apple Podcast In Good Health PodcastSubscribed to the newsletterFull ArchiveContact UsBecome an Affiliate Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Terence Tao was a child prodigy, and became a mathematics professor in the United States at age 24. In his early 30s he won the Fields Medal, known as 'the Nobel Prize of Mathematics'. Tao is considered one of the greatest living mathematicians, in part because of the breadth of his contributions to the field – from finding new patterns in prime numbers to solving several of the "unsolvable" Erdős problems. On Monday, the King's Birthday, Tao was awarded Australia's highest civilian honour, the Companion of the Order of Australia. In this bonus episode of The Briefing, Terence Tao, AC, speaks with Natarsha Belling about the pleasures of solving problems, and how maths makes the world a less scary place. If you want more Terence Tao, one of the YouTube channels he mentions is 3Blue1Brown, and Tao is featured on an episode. Follow The Briefing: TikTok: @thebriefingpodInstagram: @thebriefingpodcast YouTube: @TheBriefingPodcastSee omnystudio.com/listener for privacy information.
394 - Long before his Nobel Prize, William Faulkner published his FIRST short story, a wild one! Tuck in for an early aviation thriller as a young pilot and pure luck collide in the story that started it all.
One of the most surprising and remarkable discoveries in recent scientific history has been CRISPR. Short for Clustered Regularly Interspaced Short Palindromic Repeats, CRISPR is a form of immune system that evolved in bacteria more than a billion years ago to defend against persistent viral threats. Under attack, bacteria can snip a small fragment of a virus's DNA, store it in the CRISPR region of their genome, and then use it to recognize and destroy the same virus if it returns. The CRISPR-Cas9 system, to give it its longer name, consists of a short strand of guide RNA that identifies where to cut the DNA and a protein that acts as the molecular scissors. What made this system truly revolutionary was the demonstration in 2012 that it could be reprogrammed with different pieces of guide RNA to edit virtually any genome in any species, and at a level of precision and ease that far surpassed existing gene-editing tools. Since then, the editing capability of CRISPR has been tested on everything from developing disease treatments to engineering drought-resistant crops to resurrecting genes of extinct species. The possibilities have expanded so rapidly that researchers, ethicists, and regulators have found themselves struggling to keep up. One person acutely aware of the power of CRISPR is Jennifer Doudna, co-developer of the technology. Doudna, who received the Nobel Prize in Chemistry in 2020 with Emmanuelle Charpentier for this pioneering work, has been a prominent voice not only for its vast potential but also for its responsible and ethical use. In this episode of The Joy of Why, Doudna tells co-host Janna Levin how her early, “rebellious,” decision to study RNA led her on a serendipitous path to one of biology's most transformative discoveries. They also discuss the breakthroughs, barriers, and frontiers that will define CRISPR's true impact.
The Nobel family (which are the namesake of the Nobel prize), had a rags-to-riches story bigger than the Rockefellers or Morgans. The Nobel patriarch Emanuel fled debtor’s prison in 1837. He then travelled east and built a foundation for the largest oil empire in Russian history. Three generations of Nobels invented the world's first oil tanker, stopped the Royal Navy cold with undersea mines during the Crimean War, and outmaneuvered both Rockefeller and the Rothschilds in the world's first great corporate oil war. Then the Bolsheviks arrived. Lenin nationalized everything overnight, Stalin personally targeted the family patriarch for arrest, and the man who quietly made the Nobel Prize a reality had to escape revolutionary Russia in a horse-drawn cart wearing a disguise, with forged papers and three borrowed children to complete the ruse. It is one of the great lost stories of the nineteenth and twentieth centuries, overshadowing the very prizes that bear the family name. Today's guest is Douglas Brunt, author of The Lost Empire of Emanuel Nobel. We discuss how capitalism and Marxism grew up in the same Russian cities before their catastrophic collision, why Emanuel Nobel defied the King of Sweden to ensure his uncle Alfred's will was honored, and what it actually looked like when Lenin's pen stroke erased three generations of Nobel engineering genius in a single day. We explore this story of oil, revolution, and a dynasty that fueled the world and then vanished.See omnystudio.com/listener for privacy information.
A practicing astrophysicist who doesn't believe in the tunnel of light, the hovering soul, or the wailing relatives — but believes in one near-death experience that changed science forever. By the end you'll believe in it too. Today on Into the Impossible: the strangest, darkest, most personal origin story behind the world's most famous prize — and what it should make you do with the time you have left.
EWOT for Stroke Recovery: The Affordable Alternative to Hyperbaric Oxygen Therapy Brad Pitzele did not set out to become an oxygen therapy equipment maker. He set out to survive. After years of battling significant health challenges, conventional medicine had given him answers that kept failing him. He tried around 200 treatments. Some helped. Many did not. Then he found EWOT Exercise With Oxygen Therapy, and something finally shifted. Brad’s journey is not the same as a stroke. But what he discovered about oxygen, inflammation, and cellular energy maps directly onto one of the most stubborn obstacles stroke survivors face: the feeling that the brain has gone offline, that the body is running on empty, and that the path back is either impossibly expensive or simply does not exist. In Episode 407 of the Recovery After Stroke podcast, Brad shares what EWOT is, why it works, and why he now makes affordable EWOT systems through his company, One Thousand Roads, specifically so survivors do not have to remortgage their homes to access oxygen-driven recovery. What Is EWOT? EWOT stands for Exercise With Oxygen Therapy. The concept is straightforward: you breathe high-concentration oxygen through a mask while exercising even lightly, and that combination pushes oxygen into parts of the body that normal breathing cannot reliably reach. Most people assume oxygen therapy means a hyperbaric chamber: a pressurized tube, a clinic, a course of treatments costing tens of thousands of dollars. Hyperbaric oxygen therapy (HBOT) is effective. Brad describes it as “a heroic treatment.” But it is also inaccessible for most survivors, financially and logistically. EWOT operates on a related principle without the chamber. The key mechanism is not about oxygenating red blood cells; they are already carrying close to their maximum load under normal breathing. The target is the blood plasma. Plasma does not carry oxygen efficiently under resting conditions, but during exercise, even light exercise, blood pressure and circulation increase enough to force dissolved oxygen into the plasma. That plasma can then reach the micro-capillaries, the tiny vessels that feed tissues deep in the body, including areas of the brain that become inflamed and oxygen-starved after a stroke. The Post-Stroke Energy Problem One of the most commonly reported and least-explained symptoms after stroke is fatigue that does not go away, no matter how much a survivor rests. Most survivors are told that is just part of it. Brad’s framework centres on mitochondrial dysfunction. Mitochondria are the energy-producing structures inside cells. After stroke, the cells in and around the affected area are often not dead; they are in a kind of low-power state. Brad describes it as a “brownout”: the lights are on, but dimly. The mitochondria are not producing energy at full capacity, and one significant reason for that is insufficient oxygen supply to the tissue. “The cells that are offline after a stroke are not all dead. Some of them are just starving. Oxygen is part of what feeds them back.” — Brad Pitzele, Episode 407 When EWOT increases plasma oxygen during exercise, it can reach those inflamed, under-oxygenated micro-capillaries that larger vessels cannot access. The result, for some survivors, is a gradual improvement in energy, cognition, and physical capacity, not because the therapy is miraculous, but because it addresses a specific physiological deficit that conventional post-stroke care often does not target. EWOT vs. Hyperbaric: What’s the Real Difference? The honest answer is that EWOT and hyperbaric oxygen therapy are not equivalent. HBOT delivers oxygen under pressure, which drives it into tissue more forcefully. For certain conditions, particularly in acute or severe cases, hyperbaric oxygen has a stronger evidence base. But for many stroke survivors in the subacute or chronic phase of recovery, access is the defining variable, not theoretical ceiling. A home-based hyperbaric unit costs $50,000 to $75,000. A clinical course can run to $60,000 or more. EWOT systems are available for under $2,000. The question Brad puts to survivors is not “which is better in a lab?” It is: “Which one can you actually do, consistently, at home, over the months and years that brain recovery requires?” Consistency matters more than peak intensity in long-term neurological recovery. Starting EWOT With Deficits EWOT does not require running on a treadmill. The exercise component can be a stationary bike, a recumbent bike, or simple seated leg movements with one limb strapped in. The goal is to raise circulation enough to push oxygen into the plasma, not to hit a cardiovascular fitness target. For survivors exploring this option, Brad’s team has built a specific resource at onethousandroads.com/stroke-recovery with a listener discount of $100 to $500, depending on the package. There is also a broader introduction to EWOT at onethousandroads.com/pages/exercise-with-oxygen-therapy. Recovery Is Possible — And It Does Not Have to Be Expensive If this episode resonated with you or if you want to explore more conversations about recovery options that do not require a second mortgage, Bill’s book, The Unexpected Way That A Stroke Became The Best Thing That Happened, is available at recoveryafterstroke.com/book. And if the Recovery After Stroke podcast has been useful to you, you can support it financially at patreon.com/recoveryafterstroke. Every contribution helps keep the show going and these conversations accessible to survivors around the world. This blog is for informational purposes only and does not constitute medical advice. Please consult your doctor before making any changes to your health or recovery plan. EWOT for Stroke Recovery: The Affordable Alternative to Hyperbaric Oxygen Therapy Why pay $60,000 for hyperbaric oxygen? EWOT brings oxygen therapy into your living room — and could help the brain cells that are only offline. One Thousands Roads Exercise With Oxygen Therapy (EWOT) YouTube Channel Highlights: 00:00 Introduction and Background 05:37 Challenges in Stroke Recovery and Treatment Options 13:45 Understanding Oxygen Therapy and Its Mechanism 15:51 Oxygen Toxicity Explained 19:24 The Importance of Oxygenating Blood Plasma 24:53 Oxygen and Mitochondrial Function 31:16 Adapting Exercise for Stroke Survivors 38:27 Cost and Accessibility of Oxygen Therapy Devices Transcript: Introduction – EWOT for Stroke Recovery Brad Pitzele (00:00) like many of your listeners, when you have a medical issue that isn’t treated by traditional medicine and you’re desperate to get your life back, you’ll try just about anything. You, the lens it goes through is like, Well, how bad can this hurt me? BIll Gasiamis (00:15) Welcome back to Recovery After Stroke. I’m your host, Bill Gassiamas. Today’s guest is Brad Pitzele, founder of 1000 Roads, who overcame significant health challenges of his own and along the way discovered the science behind exercise with oxygen therapy. In this conversation, we get into how increasing oxygen saturation in the blood, specifically in the blood plasma, can help reach the inflamed microcapillaries. That are blocking oxygen delivery to cells in the recovering brain. We talk about mitochondrial dysfunction, post-stroke fatigue, and why Ewatt is worth understanding as an accessible alternative to hyperbaric oxygen therapy. Before we get into it, if you’ve found value in this podcast and want to support it financially, you can do that at patreon.com/slash recovery after stroke. And if you haven’t yet read my book, The Unexpected Way That a Stroke Became the Best Thing That Happened, it is available at recovery after stroke dot com slash book. Here’s my conversation with Brad. BIll Gasiamis (01:19) Brad Pitsley, welcome to the podcast. Brad Pitzele (01:22) Thank you so much. BIll Gasiamis (01:24) Thanks for reaching out and ⁓ connecting with me to educate me on another thing that I can bring to stroke survivors that could potentially help them in the rehabilitation side of their brain. The the thumbnail that people found on YouTube is probably gonna have E W O T on it somewhere. E what. And it sounds something like something out of that ⁓ space war out of out of what is it? Brad Pitzele (01:53) Star Wars. Star Wars. BIll Gasiamis (01:54) Star Wars. Like the Ewok, right? And it doesn’t really mean anything to me. But before we descri tell people what Ewok is, ⁓ tell me a little bit about your background, the work that you do and how it is you came to be on the podcast today is for s for for the specific discussion that we’re gonna have. Brad Pitzele (01:58) Yep. Sure. ⁓ yeah, so I ⁓ I I’m an e recovering engineer. I like to joke. I spent my first decade of my life engineering. later on in life, I left engineering and went into different pursuits and I became chronically ill, had a variety of medical issues, ⁓ cancer, autoimmunity, and eventually Lyme disease. And I was in really bad shape. And a doctor recommended I look into either hyperbaric oxygen or this exercise with oxygen therapy, EWAT, that almost no one had heard of, and I’d never heard of it. ⁓ I I I had tried like everything to get better at this point. I was many years in special diets, ⁓ all sorts of supplements and ⁓ all sorts of modalities and things. And nothing really worked. There was nothing in a matter of fact, some of the medications I took actually gave me cancer. So it kind of forced me on this road to try something different. ⁓ and eventually I found my way back to health through exercise with oxygen when so many things weren’t working. ⁓ and actually later paired that with ⁓ red light therapy. ⁓ and along the way I started because I’m an engineer and I’m inquisitive, I like It was Lyme disease is kind of a do-it-yourself disease. ⁓ so I started digging in and pouring into research, not just on Lyme disease, but autoimmunity, ⁓ chronic illness, ⁓ trying to figure out what the heck was going on with me. And so ⁓ what I found about exercise oxygen therapy along the way was really fascinating to me. and about a year into using it, I went back to that same doctor and he was kind of shocked. At my turnaround, and he was like, What did you use? Did you do oxygen? And I said, I did. And he was like, Who’d you buy it from? I want to tell my patients about it. And I said, I didn’t buy it, Doc. I actually ended up making my own. And he was kind of surprised by that for obvious reasons. And then he said, Well, gosh, would you consider making it for my patient? And so, my patients, and so that’s how we got into this business back in two thousand eighteen. We launched one thousand roads to kinda make exercise with oxygen therapy accessible to people who are dealing with chronic health conditions. BIll Gasiamis (04:39) Okay. And it stems from science, right? There’s scientific data that backs up this exercise with oxygen therapy. Before you go into that a little bit, we don’t have to go deep into it, but we can just ⁓ chat about it. ⁓ when I talk to stroke survivors, they get stuck always with what should I do? What should I do? What should I do? They want the The blue pill, take that one, everything gets fixed. I mean, stroke is not like that, right? And it’s and it’s stroke is also a you’re on your own kind of thing. Because once you get out of the acute phase, once you get sent home, the ⁓ follow up and the medical fraternity doesn’t have a system to kind of say to you, we can’t help you. Speak to that guy. ⁓ that guy might not be able to help you, but but there’s a guy over there. Brad Pitzele (05:09) Yeah. Challenges in Stroke Recovery and Treatment Options BIll Gasiamis (05:33) Like there’s none of that. And stroke survivors need podcasts. They need ⁓ people selling all sorts of crazy stuff that they will almost try almost all the time. They’ll try everything. And then they’ll pick and finally stumble into one that helps and gets them a result. But before we talk about all of that, what I want to do is also go back to what you said about ⁓ a year later, you went to your doctor, he was stunned at the result. We can’t put that down just to eat what? We can’t put that down just to exercise with oxygen therapy. Give me the brief steps on the other things that you also attended to because people miss that. Brad Pitzele (06:15) Yes. Yeah. I well, here’s what I’ll tell you. I started I started to get arthritis in my hands in like 2010 or eleven. and then I started taking traditional drugs for it. And one of the side effects of the drugs is higher risk of cancer and specifically melanoma, which I developed in two thousand thirteen, I wanna say, maybe two thousand fourteen. And that kicked me off the traditional medical path. ⁓ to your point, you don’t you don’t in the stroke recovery, there’s not a traditional path. There it was a traditional path, but it was clear that it was a you know it was a choice between cancer and autoimmunity, and neither one seemed great to me. ⁓ from there I tried so many things, Bill. I did s I actually made a list recently and looked at it because I had it like just off the top of my head, I came up with 200 different things I did try. We’re talking special diets. Eating all sorts of weird, strange things, all sorts of supplements, antibiotics, because it’s Lyme disease, herbal protocols, ⁓ ozone treatments, sa various different types of saunas, ozone sauna, infrared sauna, ⁓ heat steam saunas, ⁓ colonics, coffee enemas, ⁓ weird stuff, you know, you’d never think you’d do. I mean BIll Gasiamis (07:39) You are committed Brad Pitzele (07:42) ‘Cause like many of your listeners, when you have a medical issue that isn’t treated by traditional medicine and you’re desperate to get your life back, you will you’ll try just about anything. You the the lens it goes through is like, Well, how bad can this hurt me? Like like ’cause I know where I’m going right now. For me at least it was a I was just like this gradual step down. It was like I knew like I I couldn’t do this. I had a young family. so, you know, that doctor, I remember him saying, like, look, Brad, we’re trying all these things, we’re gonna get you on thyroid medications and get that right, and we’re gonna do this. ⁓ there on that list of 200, there were about eight things that gave me any kind of benefit that I could identify. ⁓ But I remember he’s like, Brad, we’re gonna take out the big dog. We’re gonna do this ozone treatment. And it’s a special kind where we remove the blood from your body, we inject ozone, put it through UV light, and put it back into your blood. And this helps everyone. Like if nothing else works, this helps, but it’s really expensive. So we’re saving it, kind of. So he he did it. He’s like, do a course of three of them. And he’s like, You might feel bad after it the next day because it kills a bunch of stuff and might you might feel toxic. Or you might feel better. We’re not sure. And give it a few days. And like I did all three of them, I never noticed a difference. And it was ⁓ the most depressing, scary part was like going through that. So when he said go do oxygen, I was like, Okay, like I’ve done everything else. I’m just gonna check the box so the doctor knows that’s not gonna work, so we can go try to find something else. ⁓ And I didn’t believe it was gonna work. I I you know, I didn’t jump on the the bandwagon gung-ho. I was, you know, kind of kicking and screaming. And that was part of the reason I built my own, is because at the time they were so expensive and the they were five to twenty-five thousand dollars. And I was like, I just can’t spend, you know, ten thousand dollars on an experiment. I just can’t do that. ⁓ And he also suggested maybe hyperbaric and that was like fifty or seventy-five thousand dollars. And I was like, geez, if I knew this was the the blue pill, as you said it, if I knew this was the blue pill, I’d go mortgage the house and I’d go do it because like then I could work full and I could do all the things, I could be present for the family, but ⁓ I couldn’t. BIll Gasiamis (10:05) And and and you know what? And it’s not, and and the reason it’s not for a lot of people is because you need to have penumbras the brain from a stroke survivor perspective that are recoverable and that you can bring back to life that are offline, not dead by ⁓ cell death because of the stroke. And there’s no diagnostic process in the majority of the people I’ve spoken to, you can’t diagnose somebody and then work out whether they’re a candidate, and that really Brad Pitzele (10:20) Yeah. Right. BIll Gasiamis (10:33) Pisses me off to somebody gonna have to spend 50 grand to find out if they’re gonna get a result, right? The s the guys that who I’ve interviewed about hyperbaric oxygen therapy, ⁓ Viv clinics, ⁓ those guys will do a thorough diagnostic beforehand to determine whether somebody is a candidate. And whatever that costs, even if it’s five grand, I don’t know what it does cost, but even if it’s five grand, at least you can go, you’re not a candidate, don’t spend any more money. Brad Pitzele (10:38) Yeah. Right. higher yes, you have a higher level of certainty before you spend the money. BIll Gasiamis (11:04) Yeah. And if you do do it, you’re doing it for the other ⁓ non-brain related benefits that you’re gonna get from hyperbaric oxygen therapy. And that’s totally up to you. But it’s not the thing to supposedly fix the arm or the leg that doesn’t work, or to ⁓ repair the damaged cells in your brain. So that part really frustrates me. And if I’m gonna spend that much money, then there’s the opportunity cost as well. It’s like Brad Pitzele (11:33) Yes. BIll Gasiamis (11:34) Now I can’t spend that somewhere else. Brad Pitzele (11:36) Exactly. That was me too. It was like you you knew you had and I was like, man, if I spend this kind of money on it and it doesn’t work, like nothing’s worked for the last, I don’t know, almost ten years at this point. Like how many of these shots do I have in the cannon, right? Like you you know, now I’m I’m depleted and I’m still sick. And that’s even i and you know this, when you’ve got a chronic health condition, sometimes the psych psychology of it all is just as hard as the condition. And If you’re like, wow, now I don’t have money. I feel trapped. There’s nothing I can try. Then hope starts to dwindle. And I say like hope is is like the most potent weapon in recovering from a chronic health condition. It’s a double-edged sword because like you’re s afraid to get hope up because you’ve been let down. But it’s also the thing you need. You ha like when when you start losing hope, and I and I’ve been at that point, it just gets incredibly dark. ⁓ and incredibly scary. so I I think that was part of it. I just wouldn’t allow it. It was the financial part. I you’re right. You only have so many shots out of the bow. But it was also like if it doesn’t work and I am depleted financially you know, I don’t like that that brings me to a a level of hopelessness I I’m not sure I can confront. BIll Gasiamis (12:53) Yeah. And then in order to get back up, you’re getting back up, you’re financially depleted, you’re energetically depleted, your health is depleted. And it’s like, my God, that is a that is like the lowest place that you can find yourself and to get back up is a lot harder. And yet people have still done that, but I know the task is harder. I’ve been in a similar sort of situation. Brad Pitzele (13:12) Yeah. We all love we all love reading that inspirational story. No one wants to live it if they can avoid it, I’ll tell you. Understanding Oxygen Therapy and Its Mechanism BIll Gasiamis (13:23) Avoid it. Yeah, a hundred percent. ⁓ so so you’ve tried all this stuff, you’re unwell, and then somebody says to you, try oxygen. Now, what I imagine when I hear oxygen is get a can from the local gas supplier, ⁓ pop pot in a tube, put it on the back of your chair, wheelchair. You know, I’ve seen a lot of older guys who have got it, and then they’ve got oxygen attached to their face and they’re breathing in oxygen. What specifically did your doctor tell you to get and if you didn’t get what he suggested, like w what did it look like for you? Brad Pitzele (14:00) Yeah, so the challenge with bottled oxygen is number one, it’s almost impossible to get. number two is when you exercise, you can take in a massive amount of oxygen, and that’s part of what makes the the therapy really cool. So y you and I sitting here, maybe we’re taking in three liters of oxygen a minute, okay? ⁓ three liters of air a minute, maybe something like that. ⁓ When you’re exercising, you can easily take in 50 or 60 liters. So it’s a massive multiplier. So you need something that’s going to give you a large amount of oxygen. Now, there’s two ways you can get oxygen in your home. One is that bottle you mentioned, and then you’re always refilling it, and you can imagine lugging one of those things around. ⁓ the other way is there’s a device called an oxygen concentrator, and all you do is you plug it into the wall. And it turns the it purifies the oxygen in the room. So, you know, at sea level, the oxygen in the room has 21% oxygen and it can purify it to 93%. Now, the challenge with these devices is they put out either five or ten liters of oxygen in a minute. So not enough to exercise with. If you were to try to exercise with it, you would also be sucking in this air at 21% and diluting it. ⁓ and so what you do is you take this device and you fill a large reservoir, it’s about a thousand liters, ⁓ and you fill it up. using this device and then you hook up a hose with a mask on it and then you breathe through the mask while you do a fifteen minute exercise session. BIll Gasiamis (15:41) Okay. A reservoir, ⁓ water tank. Oxygen Toxicity Explained Brad Pitzele (15:45) It well it it’s like it looks like a big pillow. So it’s like six you know, two meters by two meters, sort of ⁓ big pillow, six feet by six feet for us still on Imperial. And you fill it up so a thousand liters and it’s you know it’s it’s thin film and so it’s not a a rigid body of something, and then yeah, it’s a bag. BIll Gasiamis (16:06) It’s a bag. Like a bagpipe, a massive bagpipe. Brad Pitzele (16:10) There you go. BIll Gasiamis (16:12) Okay. Okay. W I’m sure there’s an image of that, right? We’ll put it on the screen. People can see it while we’re talking about it, trying to work out what it is. Okay. So this thing is something that you accessed and you used specifically for yourself, how many years ago? Brad Pitzele (16:16) Yeah. Yeah. I’ve s I’ve been using it for a decade straight now. BIll Gasiamis (16:33) Okay. This stuff’s been around for about a decade. This Brad Pitzele (16:37) It’s well, the the research on it goes back to the nineteen sixties and seventies. This it’s really fascinating. actually some of the early research goes back to the turn of the ⁓ twentieth century, the nineteen hundreds. So in the early nineteen hundreds, a gentleman named Otto Warburg won a Nobel Prize for proving that he could turn any cancer or any regular cell into a cancerous cell by depriving it of oxygen. ⁓ and so there’s this really well-established linkage between oxygen and cancer. Even today, a ton of research on that. So in the 1960s and 70s, there was a a German physicist and prolific inventor named Manfred von Arden. Now, and he started to want to do research on Otto’s work, and he he actually started doing research on exercising with oxygen as an anti-cancer protocol. And some of the research he found was really fascinating. what without getting overly technical, basically it our circulatory system, obviously, this is really relevant to stroke, ⁓ people deal in strokes, is as you get down into the the end runs of your circulatory system, there’s capillaries and they’re like thinner than a human hair. And this is where your nutrients and your oxygen are actually exchanged with the cell. And what he found is as we age naturally this inflammation builds up on the lining of our capillaries. And it actually causes the capillaries to swell shut so that now none of your red blood cells can get by. Now, I mean, this is how exquisite our body is designed. ⁓ our capillaries are actually thinner than a red blood cell. So under the most healthy of conditions. A red blood cell actually needs to fold up like a taco to get into our capillaries and deliver that oxygen in the last mile of our circulatory system. So any swelling in that capillary can cause a blockage. And now all the cells downstream are not getting oxygen and in a sufficient quantity. And so they kind of go into what they what he kind of referred to as like a brownout, right? Like it’s a low energy state. They’re doing anaerobic respiration to get some energy. Maybe some of the smaller red blood cells might squeak by here and there and give a little bit, but they’re not getting the full oxygen they need. And what he found is by doing this procedure, just a few times he had very elderly people with very inflamed ⁓ capillaries. He was able to re-establish normal blood flow. And the reason is is oxygen is incredibly anti-inflammatory. ⁓ and a lot of research on that we can go into a little bit later. The Importance of Oxygenating Blood Plasma So, number one, it causes this anti-inflammatory reaction inside these inflamed capillaries to reopen them. But it also does something really amazing that he discovered is when you’re doing this procedure, ⁓ it causes the oxygen to not just attach to our red blood cells like it always does, but it also saturates our blood plasma, which is this clearish liquid that our red blood cells ride on. And Our blood plasma is a thousand times thinner than a red blood cell. So if you imagine these blockages, red blood cells are not getting through, but obviously the blood plasma can get through as long as it’s like as thin as water. So as long as there’s any opening there, and it can immediately deliver oxygen downstream, both to cause an anti-inflammatory impact in the capillaries, but also to all those cells that are starving. And so you can obviously, as we’re talking through this, you can kind of see how this fits folks who are dealing with various different strokes ⁓ and how that can help them as well. BIll Gasiamis (20:32) Yeah. Okay. I d before we spoke I did a little bit of research and found ⁓ as well that there’s some there’s a lot of relevant data with regards to oxygen and ⁓ increasing the oxygenation in the blood. you so tell me a little bit about oxygen. I I don’t understand exactly what that is. I’ve heard of people becoming ill. Because of too much oxygen, ⁓ ill because of not enough oxygen. So what is what what is becoming ill of too much oxygen and why is ninety nine percent saturation not that? Brad Pitzele (21:18) Yeah, yeah. ⁓ good question. So oxygen toxicity can occur if you get too much oxygen under certain circumstances. So if you’re in a hyperbaric chamber too long, it can cause oxygen toxicity. And basically that’s when oxygen gets trapped in your bloodstream and it can’t get out. and You can actually get it without hyperbaric. So hyperbaric is oxygen under pressure. You can get it at normal barracks. So if you were just sitting on the couch breathing oxygen, you could eventually get oxygen toxicity. Now, it would take over twenty-four hours. So if you were breathing just pure oxygen, no exercise, sitting on your couch for 24 plus hours, it starts to get into the risky zone. When you’re doing exercise with oxygen, that’s actually one of the cool things about it that because of the synergies of exercise and oxygen, it’s impossible to get oxygen toxicity for two reasons. one is that reservoir is only a thousand liters. it’s not a high enough dose that you could get a oxygen toxicity. It is a massive dose, it’s about the same amount of oxygen you take in in a day, and you can take it in in 15 minutes, but it’s not more than. And the second reason, even if we could make our reservoir 10x, 100x, and you could exercise nonstop, you still couldn’t get oxygen toxicity because when you’re exercising, your body produces a massive amount of carbon dioxide gas. And that goes into our bloodstream and it increases pressure in our circulatory system. And that actually forces the oxygen out of the circulatory system and into the cells. So it works as a protectant as well from oxygen toxicity. So that’s oxygen toxicity. It’s a real risk. ⁓ Most of the time it’s a very controllable risk. You know, if you’re doing hyperbaric, they’re gonna keep you in there for so long so that you’re not gonna be at risk generally. ⁓ if you’re assigned to do oxygen while you’re stationary at home, they have protocols to make sure you’re not doing it, you know, twenty-eight hours nonstop sort of thing. ⁓ or they have you wear a cannula where where you’re also taking in air and it’s diluting it. ⁓ and in exercised oxygen therapy, it’s not really possible because of the massive amount of carbon dioxide. ⁓ now, not enough oxygen. So if you if you want to measure your oxygen in your blood, the way they normally do it is a device called the pulse oximeter. You can get one for 20 bucks off Amazon. What it does is it looks at how much how many of your red blood cells are saturated with oxygen. And what you’re gonna find in most folks. Is it’s close to a hundred percent. It’s ninety-eight percent, it’s ninety-six percent, ninety-seven percent. ⁓ there’s not a lot of room in our blood for more oxygen. So that’s why it’s important that ewak can actually oxygenate our blood plasma. The same with hyperbaric does the exact same thing, it oxygenates our blood plasma. So BIll Gasiamis (24:26) Okay. I think before you go on, that’s the key ingredient. It’s oxygenating the plasma as well. Where where previously you’ve got let’s say ninety seven, ninety eight percent saturation of your red blood cells. What we’re doing is adding that little bit of extra oxygen into the space where the plasma is. That’s kind of the key difference. Brad Pitzele (24:36) Yes. And there’s two reasons why it’s important. so normally, just for comparison, you and I sitting here, maybe 2% of all the oxygen in our blood is in our plasma, so it’s not very much. ⁓ but under these conditions of IWAT and hyperbaric, we can saturate that blood plasma. And it’s important for two reasons. One, obviously, it increases the oxygen carrying capacity of the blood, but that’s the more minor one. The more major one is that the blood plasma can get into let’s just say the nooks and crannies, smaller spaces in our body where inflammation is blocking off access of red blood cells to downstream cells. And so it can deliver a dose of oxygen where it normally is not able to get. BIll Gasiamis (25:40) You you’ve spent a lot of time on this topic by the sound of things. ⁓ and that’s really awesome. So before we talk about how to actually use a device, how to get a device, how to how to behave while you’re using a device, I wanna understand like how Oxygen and Mitochondrial Function Brad Pitzele (25:52) Yeah. BIll Gasiamis (26:02) How you notice the difference in yourself? Because a lot of people ask me what I did in my own stroke recovery. And Brad’s experience is going to be different from the stroke survivor’s experience. My experience was ⁓ I’ve got nothing from the doctors other than let’s monitor your bleed, let’s give you brain surgery. I mean, that’s not nothing. That’s amazing. Like I’m very Brad Pitzele (26:05) Yeah. Yes. BIll Gasiamis (26:31) Grateful for all of that. That removed the the blood vessel that was leaking that was going to potentially kill me. ⁓ so the immediate risk was gone. And then what what I mean I I got nothing is the specialists did their specialty and then I got nothing because they don’t do nutrition, they don’t do exercise, they don’t do meditation, they do brain surgery. And it’s really important for stroke survivors to understand that when you go to a doctor, a neurologist, whoever. Brad Pitzele (26:55) Yeah. BIll Gasiamis (27:00) They do a specific thing, and once they’ve done it, they can’t do anything else. And you need to get over the fact that you ⁓ might feel disappointment at the at that I don’t know where to go next, and they don’t know where to send you. Okay, they’re not trained and they cannot legally send you elsewhere. That’s why you’re kind of on your own. So I did meditation, I did nutrition, I did all this kind of stuff and Brad Pitzele (27:16) Yeah. BIll Gasiamis (27:27) Somebody who’s interviewed you is Dave Asprey. I would I’ve been following Dave Asprey and a whole bunch of other guys ⁓ probably since around 2012, 2013. And what I learned was how do I reduce the inflammation in my brain? And I had that one area of inquiry, the one area of inquiry that I could personally impact positively by taking out inflammatory foods from my diet. And before that it was, you know, ⁓ processed white bread, it was alcohol, it was cigarettes, ⁓ it was all the stuff that you get in a packet that doesn’t really help to nourish the body, right? So I went back to basics. We’ll call it just for the simplicity of the explanation, we’ll call it protein, ⁓ vegetables and basic carbohydrates like rice or potato. And then what I found was that inflammation decreased, and that was a game changer in how I experienced my brain. And it was a game changer in how quickly I improved neurologically. But just so that people know, it wasn’t the be all end all, it didn’t remove the damaged cells that still are in my head that mean I experienced my the left side of my body in a completely different way than my right side. I’ve got numbness, proprioception issues. I’ve got ⁓ tingling, I’ve got burning, I’ve got ⁓ spasticity, you know, the muscles are tight. So all that stuff is still there. But I have a better experience of the rest of my body and brain because of the things that I took out. But what I didn’t have was the link between exercise, which I do, light exercise, because I’m a stroke survivor. I can’t. use the left side of my body like I used to. so I would do exercise ⁓ like riding an electric bike because it’s easier to pedal, like walking and like doing very light weights at the gym. ⁓ but I didn’t have that oxygen part of the the therapy. And that’s kind of why I interviewed the guys about hyperbaric to understand how oxygen supports how mimicking i a hypoxic brain in the chamber supports ⁓ so how how does like what’s the next part like how does that support the brain to heal let’s give stroke survivors an understanding so that they can kind of grasp that I know we spoke about how oxygen gets into the ⁓ into the red blood cell we spoke about how it gets into the plasma but like Brad Pitzele (30:15) Yeah. BIll Gasiamis (30:20) Why is that the next step? Brad Pitzele (30:21) What’s it too? Yeah. It’s a good question. I think you’re right. I you know, we don’t I will say we don’t try to go out and pitch like exercise with oxygen therapy is a panacea or it’s everything for everyone. Even the name of our company, ⁓ one thousand roads, is about paying homage to everyone’s own healing journey and recognizing everyone’s unique journey. So I’ll say that, but So I’ll say that, but what I found about oxygen was in IWA in particular. What was fascinating to me was for me when I was dealing with Lyme disease, which similar to folks who are dealing with the stroke, there’s a variety of different symptoms and s from different causes. And I was trying to treat all these things with different protocols, different supplements that and I found that when I started digging into oxygen, I was shocked at how many of them came back to it. So when you have A stroke, often there’s a lot of ⁓ emerging research about mitochondrial dysfunction. And this is interestingly, mitochondrial dysfunction. Now ten years ago when I was researching it, no one heard of it or cared about it. And it’s really burst onto the scene because you’re gonna find it ⁓ At the heart of so many chronic health conditions, right? ⁓ you’re gonna it’s actually they’re looking at it in cancers, ⁓ chronic illnesses of all sorts, Alzheimer’s, all sorts of cognitive and ⁓ autoimmune conditions, etc., etc. So ⁓ you have this disrupted mitochondria, right? So there was a period of time when your cells were not getting enough energy, whether it was a hemorrhagic stroke and Blood wasn’t being delivered to those cells, so no nutrients, no oxygen, or an ischemic stroke where they were just cut off ⁓ because of a clot or whatnot. And so they were not getting nutrients. In each of these cases, what happens immediately when the cell runs out of oxygen, like I was talking about that brownout, it goes from aerobic respiration to anaerobic respiration. And anaerobic respiration, ⁓ it’s It only can produce 5% of the energy as aerobic. So the cell is in a low energy state, which is the first problem, which means it doesn’t have energy to repair, it doesn’t have energy to take out the trash, detoxify. so it’s kind of stuck. But also ⁓ it creates a lot of metabolic waste. So it creates lactic acid, it creates free radicals, all these things produce more inflammation, like you were talking about. So Now we’ve got these mitochondria, which are dysfunctional. They don’t have the energy to repair. They don’t have the energy to take out all these dead cells or ⁓ you know, all these other byproducts of the immune system and the natural kind of response to this damage, which then leaves more of it hanging around to produce more damage, and they’re producing more damage themselves. So it’s kind of like this swirl, and it’s ⁓ you know, it’s a downward swirl, if you will. ⁓ so When you can re-oxygenate the mitochondria, the first thing you’re doing is you’re giving them the energy to do whatever it is they need to do. ⁓ and that can be the immediate like feeling sharper, like, ⁓ I feel like I can get my thoughts together quicker. ⁓ it can be, ⁓ I feel like I’m more in control of my emotions. And I I don’t feel like sometimes I have a disproportionate emotional response to something. It can be I I don’t have that brain fog. ⁓ you know, that sort of thing. Or I literally have energy. So our brain actually consumes like 20% of all the oxygen in our body. And it’s only like two percent of the mass. So it’s like punching 10x its weight, right? So when your body starts running low on oxygen, it starts conserving. And the one of the things it tells you to do is like cool it, like stop using your muscles. You’re tired. You need to just sit there and veg out. BIll Gasiamis (34:06) Mm-hmm. Brad Pitzele (34:27) while our mitochondria try to catch up. And so that’s often that chronic fatigue that folks with a variety of health conditions, including stroke, feel, which is their bodies like, stop using energy, we don’t have enough. We need to redeploy it for something else more pressing. And so When you can reestablish normal oxygenation, it improves energy. ⁓ it improves sleep, it improves memory. and the the cells have energy to start repairing and detoxifying. ⁓ and then obviously I always think it’s cool because we’re pairing it with oc with exercise. And there’s so much research on the benefits of exercise. You mentioned it was so important, Bill, in in your healing journey. And you know, we know how important exercise is for a stroke survivor. Well, now we’re pairing it with oxygen and we’re using that exercise to catapult more of that oxygen around the body through the circulatory system while your blood vessels are dilated and opening up. So if you’re still dealing with blockages in your microcirculation, which most stroke survivors are. You’re opening them as wide as they they naturally can at that moment, and that’s when we’re feeding more oxygen to them. So it works it kind of hand in hand in that respect. BIll Gasiamis (35:48) All right. Now one glitch. Stroke survivors often are struggling to get into the physical recovery, right? Because the body goes offline, one of the legs doesn’t work, one of the arms doesn’t work. It’s a real challenge, right? So how how can we benefit from that even though we are at just after the acute phase where there is not a lot of capability for Brad Pitzele (36:00) Yes. It’s perfect. Yeah. BIll Gasiamis (36:17) physicality and I I say that so that the stroke survivors listening know that what I’m leading to is that early on it’s probably harder to do ⁓ physical therapy, exercise, et cetera. But again, with time and hope, all of those things can improve. Right. So I I wanna put that out there for stroke survivors, but also like it’s a can it’s a it’s a constraint. Brad Pitzele (36:48) Yeah. And you know, because a lot of our customers are dealing with chronic illness, this is a question that’s not uncommon is like, yeah, but I can’t I’m not out here to run a mile, Brad. I’m like eighty years old and I’m sick or whatever it is. The really ⁓ the really cool thing about ⁓ Ewatt is that it will meet you where you are at. So there is something all of us can do. The goal is to increase your heart rate and your circulation. Cost and Accessibility of Oxygen Therapy Devices and breathe the oxygen. So there’s a few ways you can do it. you know, it doesn’t have to be banging it out on a treadmill trying to get your seven minute mile. ⁓ you don’t need to do that. We have folks, you know, depending on where they are, you can start with slow walking on a treadmill. You can start with calisthenics. You can start with stretching. ⁓ gentle aerobics in your living room. You can start by, you know, lifting weights. You could be sitting and lifting weights with the the hand that’s not. We have folks, and this is probably not so much for ⁓ stroke survivors, but maybe jumping on a ⁓ a rebounder, like a little trampoline if you’ve got the balance one with the handle. ⁓ we have people using under-the-desk pedal bikes, the ones you can get for $49 on Amazon while you’re sitting. BIll Gasiamis (38:03) Beautiful. Brad Pitzele (38:04) while you’re sitting in a chair. And then for the folks who can’t do any of that, we have we even have them doing what I call passive Ewatt, which is they will breathe the oxygen while they get in like a an infrared ⁓ sauna blanket. So infrared sauna will increase your heart rate. And so you will get some benefit out of it. And what normally happens, the the really cool thing about exercising with oxygen is The first thing folks notice, the very first benefit most folks notice when they start doing is the exercise is easier. So I always describe this like if you were ⁓ jogging on a treadmill at, I don’t know, pick a number, you know, four miles an hour and you put the mask on, you wouldn’t feel like you were getting the same exercise at four miles an hour. You you crank it up to four and a half, and then later you crank it up more. And Your endurance actually improves much more quickly than if you were just doing exercise alone. ⁓ and there’s a ton of actually research on you know Olympic athletes using it for performance enhancement, which is not what we’re using for in this, but it’s kind of a nice little side effect. So we have folks who come to us who who are out of condition. We’re not talking about the physical disabilities, but out of condition, we’re like, I couldn’t do. And they’re shocked at what they’re doing and they come back and tell us in three months, look what I’m doing, sort of thing. ⁓ But it will meet you where you’re at. So if you want to do passive Ewatt, you can do that for a while as you’re working and as you start to feel better. Then maybe you’re using the under desk pedal bike. And as you’re getting your balance back and feeling better, maybe it’s a a real stationary bike later or walking on a treadmill and so on and so forth. ⁓ the goal isn’t to bust hump and like try to, you know, get a new record. As a matter of fact, I find that for most folks that sets you back. You wanna kind of you wanna do within an envelope that you’re comfortable with because If we work out too hard, also we set ourselves back because in most chronic health conditions and in stroke, additionally, we talked about this fatigue that’s due to an energy deficit. So if you go out there and overwork, you’re just putting your body in more of a deficit and potentially putting it in more of an inflammatory environment. And we’re trying to do this at a level that’s in you know anti-inflammatory and helping you recover. BIll Gasiamis (40:30) I love that. I love your whole explanation. So in my what I was hoping was you were gonna say that I could just sit there and almost do nothing ⁓ as a stroke survivor, where I’m completely in in just, you know, like week three of the acute after the acute phase, and fatigue is a massive issue and energy is a massive issue, and I’m barely able to stay awake, ⁓ and all of that stuff. And then ⁓ you could do just I hope you I was hoping you were gonna say, But you said the equivalent of ⁓ chair yoga, you know, where all I had to do was just move an arm or move a leg and do something just to get me physically going and then it would benefit. That’s what I love about it. The under-the-leg pedal bike, ⁓ under-the-desk pedal bike is one of the best things because you can strap in your leg with the deficits if you have a leg that has deficits, and you can do all the or the majority of the pedaling with the other leg, which is strapped in. Brad Pitzele (41:07) Mm. BIll Gasiamis (41:29) And you don’t you’re not gonna fall over ’cause you sit in in a chair. ⁓ probably you’re doing it inside your house so the the temperature, the weather is always perfect and ⁓ and you don’t have to door for long, right? You only have to door for a few minutes to start with. Brad Pitzele (41:45) And you’re pulling that other leg around and it’s starting to fire inside here and rebuild those connections. And and as you know, exercise increases ⁓ brain drive neurotrophic factor, which is a growth factor in our brain for BIll Gasiamis (41:51) Mm. Brad Pitzele (42:00) neuroplasticity. So you’re getting you’re getting all of these benefits. So you to your point, for someone who’s if it’s my right leg’s not working and I’m strapped in and my left leg’s doing it, my right leg is firing and it’s firing those neurons at the exact time you have that B D N F as it’s called. So BIll Gasiamis (42:17) BDNF’s amazing. And I also interviewed ⁓ recently a gentleman who ⁓ had spoken about ⁓ Jack Clifford on episode 402 who spoke about kind of ⁓ a protocol that enables you to regenerate blood vessels around the area that’s injured ⁓ to increase the oxygenation and the blood flow ⁓ to potentially those areas where ⁓ brain is offline, not dead. ⁓ so all of these things, ⁓ the previous episode that I recorded with Jack, your episode right now, like all are things that you can do that support brain health, brain recovery, ⁓ overcoming all the some of the challenges that stroke causes. And what I love about this specifically is that you can do it from your house. and you don’t have to go anywhere, but there is a cost. So let’s talk about the cost a little bit because I I want to mention it because of the massive difference to hyperbaric, which can cost up to sixty grand if you go on the right protocol. And ⁓ that’s unattainable for most people, let alone a stroke survivor who just lost their ability to earn ⁓ and may not have sixty grand to splash. Brad Pitzele (43:48) Yeah. BIll Gasiamis (43:48) ⁓ so what is the cost of getting a machine, setting it up and putting it in your house? Brad Pitzele (43:54) Yeah. So we sell two different machines. ⁓ we have one machine that’s eighteen hundred and ninety-nine dollars and the other one that’s twenty-four ninety-nine. ⁓ that’s everything you need to get going other than the exercise equipment. and the machines last a long, long time. I think I You know, I think we actually we’ve been in business since 2018 and we had our first customer come back and tell us they wore out their machine like this year. So I have to stop saying we’ve never had one wore wear out yet. So we’ve had one. ⁓ so it it’s one of I think that’s one of the things that’s great about it is it’s something you can do in your house. It’s something that doesn’t take a lot of time. When I was dealing with my chronic health issue, I was joke around about the ceremonies of counting pills and doing this modality and doing that. And they all in stroke survivors, I think, recognize the same thing. It starts to crowd out your life. And then eventually you kind of throw your hands up. You’re like, I it might be helping, but I just don’t have four hours a day for all this stuff. Like I just I need to go on and and live my life too. So it’s something that ⁓ it’s 15 minutes. You do it three to five times a week in your home. ⁓ it’s a one time expense and then it’s you know, it’s something you’ll have for many, many years. BIll Gasiamis (45:12) I love it. Where are you located? Brad Pitzele (45:15) We’re in a Dallas, Texas area. BIll Gasiamis (45:17) Okay. And are these things easy to get and distribute throughout the United States and other places in the world? I don’t know I’ve never heard of it before. So are there other people around who who sell a product that’s similar or can you access them easily? Brad Pitzele (45:35) Well, we do ship worldwide. ⁓ we ship with US power, so people get a power converter we’ve sold to the UK, to Australia, to all over Europe, Asia, ⁓ South America, ⁓ and of course across North America as well. So ⁓ they’re readily accessible. Kind of our mission was You know, when the doctor asked me if I’d make him first patients, I I I I thought about what you were saying about how like spending sixty grand to find out if something’s gonna work. And I felt like I was taking advantage a lot when I was very ill. So we wanted to make something that was accessible to people who are chronically ill. They might not have the ability to earn money. They’re on a fixed in like I have a I guess a deep personal experience and empathy there sort of thing. So ⁓ that’s yeah. So we ship worldwide. BIll Gasiamis (46:27) Yeah. If somebody wanted to reach out to you just to get more information, to have a chat with you, to look at your website, where would they go? Brad Pitzele (46:35) They would go to 1000roads.com slash stroke recovery. We do. And you can find it at the bottom of that webpage, but it’s 1000 Roads HQ. BIll Gasiamis (46:42) And you have a YouTube channel. Okay. What kind of ⁓ things can people find on the YouTube channel? Brad Pitzele (46:56) you can find everything about protocols, benefits, ⁓ how to use it. ⁓ we hit have some customer testimonials and parts of that. ⁓ just talking about the science of it, people’s experience with it, et cetera, et cetera, different use reasons people use it. BIll Gasiamis (47:17) I think it’s very important to bring information like this to stroke survivors so that they can access things in their own home that’s going to make their life better. I wrote a book, The Unexpected Way That a Stroke Became the Best Thing That Happened, for the explicit reason to give people like a path forward, a journey forward as to how to ⁓ s how to kind of obtain the silver lining in stroke recovery. And when I wrote it ⁓ in 2018, when I started writing it, something like that, 2018, 2019, I was lacking a lot of the extra pieces that I could put into ⁓ the mindset chapter, for example, or the exercise chapter, or, you know, the nutrition chapter. And In the last five or six years, I’ve been picking up those pieces to sort of attach to those chapters because they’re really relevant. And with the exercise chapter, I think this protocol was the one thing that was missing because I made the point of how important exercise was. I didn’t make the point of how you can exercise and get more bang for your buck during that exercise by Increasing the amount of oxygen that you were getting into your ⁓ bloodstream. How would I have known that if I hadn’t come across the science, which I hadn’t? Plus, there’s only so much you can put in each chapter, but this is the perfect addition. Like, and I love it. So I can go on and on about how much I think this is amazing. Brad, I really ⁓ want to thank you for reaching out and joining me on the podcast. Thanks for the work that you do. I’m glad that you’ve been able to get your health back and now you’re helping other people. Brad Pitzele (49:06) Thank you so much, Bill. I appreciate you having me on. BIll Gasiamis (49:08) Well, that’s it for another episode of the Recovery After Stroke podcast. I hope you enjoyed this episode. Might be worth listening to it again. The science here is worth sitting with, oxygenating the blood plasma, reopening inflamed microcapillaries, giving mitochondria what they need to shift out of that low energy state. And the fact that it can be done at home at a fraction of the cost of hyperbaric oxygen therapy makes it worth knowing about. If you want to learn more, or explore the equipment, head to 1000Roads.com Stroke Recovery. Brad has arranged a discount for listeners of this show of between one and 500 dollars, depending on the package you choose. This episode pairs well with the episode 402 with Jack Clifford, which covers a protocol for regenerating blood vessels around the injured area of the brain. The two conversations complement each other. Worth going back to if you haven’t heard it yet. Now, if this episode was useful, please share it with someone who could benefit. And my book, The Unexpected Way That a Stroke Became, the Best Thing That Happened, is available at recoveryafterstroke dot com slash book. And if you’d like to support the show financially, I would love it if you could. You can go and do that via patreon.com/slash recovery after stroke. I’m Bill Garciamas. Thanks for listening. See you on the next episode. The post Brad Pitzele – How Exercise With Oxygen Therapy Brings Hyperbaric-Style Benefits Home appeared first on Recovery After Stroke.
Superteams: The Science and Secrets of High-Performing Teams by Ron Friedman https://www.amazon.com/exec/obidos/ASIN/198218633X https://Superteamsquiz.com/superteams-masterclass Ronfriedmanphd.com The ultimate playbook for building high-performing teams, packed with counterintuitive insights, surprising science, and real-world lessons from the most comprehensive study of elite groups ever conducted. What do the best teams do differently? To find out, award-winning social psychologist Ron Friedman surveyed thousands of teams and pinpointed the precise habits that separate the best from the rest. The results upend everything we think we know about teamwork. It turns out that the most successful teams aren’t the ones that collaborate most, get along best, or put in the longest hours. What really sets them apart is the way they manage their energy and attention, bring out the best in one another, and keep improving over time. Blending eye-opening discoveries with unforgettable stories, Superteams takes you inside the writers’ room of Succession and Bridgerton, the recording studio of ABBA and Fleetwood Mac, the kitchens of Michelin-starred restaurants, the laboratories of Nobel Prize–winning scientists, the locker rooms of NBA and NFL teams, and the boardrooms of the world’s most innovative companies. You will learn: -A simple rule that instantly cuts meeting time in half -How the best teams make focus easier, not harder -The one question that makes team decisions up to 30% smarter -The only office perk that improves performance (spoiler: it’s not coffee) -How personal productivity hacks make teamwork harder -Why feeling like the smartest person in the room is a red flag -Why top performers care more about disappointing their peers than their boss -How the best teams avoid burnout without working fewer hours -The science of truly restorative breaks, evenings, and vacations -How to build a team that keeps getting better (even when you’re not in charge) Smart, insightful, and relentlessly practical, this is your science-backed guide to turning your team into a Superteam. About the author Ron Friedman, PhD, is an award-winning psychologist who helps leaders build high-performing teams. He is the bestselling author of The Best Place to Work and Decoding Greatness, and the founder of Superteams, Inc., where he delivers keynotes, workshops, and executive advisory to senior leaders around the world. An expert on human motivation, Friedman has served on the faculties of the University of Rochester, Nazareth College, and Hobart and William Smith Colleges. He contributes regularly to Harvard Business Review, and his work has been featured in The New York Times, Financial Times, Bloomberg, NPR, CBS, FOX, NBC, Fast Company, The Washington Post, Forbes, and Inc.
PLEASE SIGN UP ON PATREON, EVEN IF IT'S FOR FREE! Posting everything here has become a burden, and if you're only listening to this feed you probably aren't getting all of the episodes. Sign up now at Patreon. It’s two podcasts (Pod Yourself and the Frotcast) for the price of one! Patreon dot com slash frotcast! This episode is free, but $5 a month gets you all the premium ones (two a week!). This week on the Frotcast, bitter infighting consumed the group chat as the third day of negotiations about what to watch for this episode reached an impasse. While the talks were Vanced, the Strait of Discourse stayed mercifully open. What we're trying to say is, We didn't watch a movie this week. Sorry. Rapper/pornographer Ray J has months to live. He also has a very strange interview with Cam Newton's silly hat. Ray J answers the question “Are you gay?” with a story about what people do when they go home. It gets worse from there, believe it or not. A sample exchange: Ray J: “Do you listen to Biggie Smalls?” Cam: “Can you just answer my question?” We'll always love you for moving your hat 7 times in a 30 second conversation, Ray J. What we do in life echoes in eternity. Then we get some IRL Kyle Mooney action when streamer 4_Inches gets spotted at In N Out Burger (drink!) by Jakob with a K (drink!), the lead singer of Sublime (drink!). What follows is one of the dumbest conversations we've ever been privileged to hear. This then leads to one of the Frotcast's top two or three Nobel Prize-worthy anthropological theories; Socal bros = saltwater juggalos (drink!). Next, many are calling it The Most Australian Story Ever: man uses his dog to unsuccessfully bludgeon a murderous crocodile but is mercifully saved by a Sheila having a ciggy and his mate Kevin Bevin, who then blesses us with a wonderful new term for a penis. Finally, someone tried to assassinate Trump again, but this time it was a libbed out soyboy who geared up for murder and then took a mirror selfie doing the Lin-Manuel Miranda lip bite. WHY DOES THIS KEEP HAPPENING?? Perhaps making campaign pledges to only the most insane people in America and then aggressively doing the opposite has some sort of deleterious effect on said crazy people. Who can really know what is in anyone's heart though? The Frotcast's official BPD GF Olivia Reingold did what any good WCHP dinner journalist would do and documented the action by taking a selfie video. You can poison our houseplants any day, girl.
Join Jim and Greg for an all-crazy Thursday 3 Martini Lunch as they discuss Paul Krugman's call for the de-MAGAification of America after President Trump leaves office, Democrats' refusal to condemn the growing scandals surrounding Graham Platner, California government unions fighting return-to-office orders, and Virginia Sen. Mark Warner's complaints about the Supreme Court.First, Jim and Greg blast far-left Nobel Prize-winning economist Paul Krugman's argument that the United States should undergo a "thorough purging" of the MAGA movement, comparing it to Germany's de-Nazification process after World War II. Next, they hammer Democrats such as Colorado Sen. Michael Bennet and Senate Minority Leader Chuck Schumer for continuing to dodge questions about Platner's mounting controversies. Jim asks whether Democrats are willing to enforce even the most basic standards of character and accountability for their own candidates.Then, Jim and Greg are baffled by California unions representing government employees continuing to push for delays in returning to in-person work. They also laugh at the arguments for them not coming back to work.Finally, they react to Sen. Mark Warner's accusation that the Supreme Court is showing partisan bias in its congressional redistricting rulings. Jim and Greg explain why the decisions are not a double standard and how the court is really approaching these issues.Please visit our great sponsors:QuoMoney is on the line. Always say hello with QUO. Try QUO for FREE PLUS get 20% off your first 6 months when you go to https://Quo.com/3ML ZocDocStop putting off those doctors' appointments and visit https://Zocdoc.com/3ML to find and instantly book a top rated doctor today.Pocket HoseFor a limited time, get two free gifts—a 360° rotating pocket pivot and a thumb drive nozzle—when you buy the Pocket Hose Ballistic; just text MARTINI to 64000, message and data rates may apply.New episodes every weekday.
Kidneys, surrogacy, prostitution, gambling, price gouging, assisted dying: some transactions make people recoil, even when all parties consent. Cato's Ryan Bourne talks with Nobel Prize-winning economist Alvin Roth about his new book, Moral Economics, what makes markets “repugnant,” what economists can add to moral debates, and why banning exchange rarely makes scarcity, exploitation, or hard trade-offs disappear. Hosted on Acast. See acast.com/privacy for more information.
The Prime Minister unveils a new AI strategy that he says will help Canada catch up with the rest of the world. Our guest says it's a start, but it could use some fine-tuning. Hezbollah has rejected a ceasefire deal brokered between Israel and Lebanon; our guest in Beirut tells us people there were already referring to it as a "less-fire" anyway. A protestor in Albania tells us a crucial stopover for migrating birds is in danger of being destroyed — because Jared Kushner and Ivanka Trump want to build a resort. Trixie and Nacho have been busy getting busy — which is great, because the prolific parakeet couple are almost singlehandedly rebuilding New Zealand's kākāriki karaka population.A scientist explains how the late Nobel Prize-winning physicist Richard Feynman devised a mathematical solution to the eternal question: stick with your favourite restaurant, or risk trying somewhere new?Blanket forts aren't just a quilt draped over some stuffed animals on the couch anymore — now that some students in Las Vegas have definitively shattered the world record for building the biggest one ever."As It Happens", the Thursday Edition. Radio that's usually suspicious of blanket statements.
For a subject that won the Nobel Prize in 2012 and could be considered a scientific miracle, we surprisingly don't hear a lot about cloning today. This episode, Dr. Vilceu Bordignon joins Dr. Samantha Yammine to give us an update on where we are with the science of cloning and how that technology is moving forward. Sam also looks into some new studies that explain why some old houses feel haunted and a surprisingly eco-friendly way to deal with termites. Link to Show Notes HERE Follow Curiosity Weekly on your favorite podcast app to get smarter with Dr. Samantha Yammine — for free! Still curious? Get science shows, nature documentaries, and more real-life entertainment on discovery+! Go to https://discoveryplus.com/curiosity to start your 7-day free trial. Terms apply. Hosted on Acast. See acast.com/privacy for more information.
Episode 2826 - In this wide-ranging and practically grounded episode, Ted and Austin Broer connect ivermectin's cancer research suppression, the Lakeland data center community victory, 9/11 hologram theory, Ebola outbreak immune guidance, Berberine as a GLP-1 alternative, and the magnesium brain food product of the week into a broadcast that delivers both urgent health science and sharp cultural and geopolitical awareness.The episode opens with Ted presenting the suppressed ivermectin cancer research, walking through its documented antiparasitic mechanisms that disrupt cancer cell metabolism and its transformation from Nobel Prize-winning drug to government-blacklisted treatment following a coordinated smear campaign by health agencies. Ted's personal account of a neighbor recovering from lung cancer after antiparasitic treatment reinforces what he frames as one of the most consequential medical suppression stories of the past decade.
Geoffrey Hinton is an AI pioneer, a Nobel Prize winner, and a professor emeritus at the University of Toronto. Hinton joins Big Technology Podcast to discuss AI's rapid progress, why he believes today's systems already understand us, and why he thinks superintelligence may arrive sooner than many expect. Tune in to hear Hinton explain why the technology has advanced faster than he anticipated, and lay out the risks he believes society is not doing enough to address. We also cover AI-driven job loss, the limits of corporate self-regulation, Anthropic and OpenAI's safety challenges, emotional attachment to chatbots, information collapse, and whether future AI systems can be designed to care about humans. Hit play for a fascinating conversation with one of AI's founding figures about where the technology is heading and what it could mean for all of us. Join the Big Technology AI Summit in San Francisco on June 18: summit.bigtechnology.com --- Enjoying Big Technology Podcast? Please rate us five stars ⭐⭐⭐⭐⭐ in your podcast app of choice. Want a discount for Big Technology on Substack + Discord? Here's 25% off for the first year: https://www.bigtechnology.com/subscribe?coupon=0843016b Learn more about your ad choices. Visit megaphone.fm/adchoices
To really understand the nuts and bolts of economics, look to the black market. Alvin E. Roth is Craig and Susan McCaw Professor of Economics at Stanford University and the George Gund Professor of Economics and Business Administration Emeritus at Harvard University. He was awarded the Nobel Prize in Economics in 2012. He joins host Krys Boyd to discuss his work on organ donation which led him to study what he called “repugnant transactions” like sex and drugs and why he feels banning them completely doesn't always have the effect we think it does. His book is “Moral Economics: From Prostitution to Organ Sales, What Controversial Transactions Reveal About How Markets Work.” Learn about your ad choices: dovetail.prx.org/ad-choices
Have you ever scrolled Netflix for 25 minutes, finally picked something—and then couldn't enjoy it because you kept wondering if there was something better? Or told yourself that if you just had more time, more space, or more freedom, you'd finally write the book, start the business, or get serious about the creative work you keep putting off? We've been sold the idea that more options and more freedom make us happier and more creative. But what if the opposite is true—what if all that freedom is actually making you stay stuck? My guest is David Epstein, a New York Times bestselling author whose TED talk has been viewed more than eight million times. His new book, Inside the Box, makes the case that the limits we resent might be the very thing standing between us and our best work. Some of the things we discuss are: Why "think outside the box" is actually terrible advice—and what your brain does instead when you hand it a blank page. The reason too much freedom raises your anxiety. The jazz pianist who turned a near-disaster into the best-selling solo piano album of all time. The "satisficing" rule a Nobel Prize winner used to free up his mind—and why he owned only three sets of clothes. Why "maximizers" who hunt for the best option end up less satisfied, more regretful, and unhappier with their lives. David's simple three-letter framework (BCS) for putting useful constraints into your work and your day. The almost embarrassingly simple trick David uses to become a morning person and never skip a workout. The Therapist's Take: my three favorite strategies for using constraints to think more creatively, make faster decisions, and grow mentally stronger. Related Episodes 126 — Overcome Choice Overload to Make Smarter, Faster Decisions without Regret 316 — How Talking to a Duck Will Solve Any Problem Fast (And Why Thinking Harder Fire Backfires) Links & Resources Inside the Box Connect with the Show Buy a copy of 13 Things Mentally Strong People Don't Do Connect with Amy on Instagram — @AmyMorinAuthor Visit my website — AmyMorinLCSW.com Sponsors Helix Sleep —Go to helixsleep.com/STRONGER to get 20% off sitewide AirDoctor — Head to AirDoctorPro.com and use promo code STRONGER to get UP TO $300 off today! One Skin — Go to oneskin.co/STRONGER and use code stronger to get up to 30% off your first 3 subscription orders Quince — Go to Quince.com/stronger for free shipping on your order and 365 day returns! Flamingo — Get a $7 starter set at ShopFlamingo.com/STRONGER Subscribe to Mentally Stronger Premium for exclusive content like weekly bonus episodes, mental strength challenges, and office hours with me. Learn more about your ad choices. Visit megaphone.fm/adchoices
Peter Diamandis has built more of the future than almost anyone alive. He founded XPRIZE. He co-founded Singularity University with Ray Kurzweil. He started Human Longevity with Craig Venter. And in his new book with Steven Kotler, We Are as Gods, he argues that artificial intelligence isn't just changing what we can do. It's changing what it means to be human. I'm not so sure. This is Peter's fifth time on Into the Impossible, and the conversation I've been waiting years to have. His thesis: AI will deliver not just intelligence at scale, but wisdom — and humanity is already crossing the threshold into godlike capability, whether we're ready or not. My pushback: an experiment one of my students and I ran shows large language models trained only on pre-1911 physics cannot reproduce what Einstein did with the same data. If wisdom were just scale, that shouldn't be true. We go after it for an hour. No hedging, no softening. What you'll hear: — Whether AGI can manufacture genuine wisdom or just better simulations of it — The pre-1911 Einstein test and what it reveals about the ceiling of current AI — The "five forks of humanity": longevity, BCI, off-planet speciation, creators vs. consumers, and uploading — What happens to human purpose when scarcity disappears — Why Peter thinks India dominates the next twenty years of science and technology — Peter's Fermi paradox theory and why he thinks we may be someone else's biosphere experiment — The Future Vision XPRIZE and how dystopian training data may be making AI more dangerous — David Sinclair's epigenetic age-reversal trials, now underway in human eyes Peter says what you did between breakfast and dinner would be godlike to your grandparents. We just stopped noticing. Subscribe if you want science with evidence, not speculation. CHAPTERS 00:00 Diamandis: AGI will generate wisdom by simulating billions of outcomes 04:07 Brian's counterargument: wisdom requires embodiment, not just simulation 07:07 The GPU + LLM architecture may already be a local maximum 09:48 AI is outpacing most math PhDs but the ceiling is still unknown 15:30 Diamandis fires back at the doomers 17:59 AI will eventually untangle the legal systems blocking the future 23:18 The Singularity has religious qualities and both hosts take that seriously 29:37 Post-scarcity splits humanity into creators and consumers 36:08 Peter's Fermi paradox theory: we may be someone else's biosphere experiment 43:07 Dystopian AI training data may be causing misalignment 51:46 Human trials are underway for epigenetic eye age reversal ——— Get the transcript, fascinating bonus content, and my Monday M.A.G.I.C. Message: https://briankeating.com/yt Have a .edu email and live in the USA? You automatically win a meteorite: https://BrianKeating.com/edu Subscribe: https://www.youtube.com/DrBrianKeating?sub_confirmation=1 Support Into the Impossible on Patreon — get my weekly M.A.G.I.C. Message, unfiltered bonus content, and live monthly Office Hours with me: https://www.patreon.com/drbriankeating Join this channel for perks, monthly Office Hours, and your name in the Member Roster at the end of every episode: https://www.youtube.com/channel/UCmXH_moPhfkqCk6S3b9RWuw/join My books: Losing the Nobel Prize (memoir): http://amzn.to/2sa5UpA Think Like a Nobel Prize Winner: https://a.co/d/03ezQFu Focus Like a Nobel Prize Winner: https://a.co/d/hi50U9U Galileo's Dialogue (first-ever audiobook): https://a.co/d/iZPi9Un More: Peter Diamandis Moonshots Podcast: https://www.diamandis.com/podcast Peter Diamandis Substack: https://metatrends.substack.com/ Future Vision XPRIZE: https://futurevisionxprize.com/ Book We Are as Gods: https://a.co/d/0bfz2pBo Peter Diamandis YouTube: https://www.youtube.com/@peterdiamandis Follow Peter on X: https://x.com/PeterDiamandis Twitter/X: https://x.com/BrianKeating Substack: https://briankeating.substack.com Blog: https://briankeating.com/blog Audio-only: https://briankeating.com/podcast #intotheimpossible #briankeating #science #physics #astronomy #cosmology #podcast #universe #peterdiamandis #ai #agi #singularity #abundance #longevity Learn more about your ad choices. Visit megaphone.fm/adchoices
© 2020-2026 Ivy Podcast Discovery LLC
