POPULARITY
6 episodes with Barry Marshall
2 episodes with Barry Marshall
2 episodes with Barry Marshall
2 episodes with Barry Marshall
2 episodes with Barry Marshall
3 episodes with Barry Marshall
In this cutting-edge episode of Impact Theory, Tom Bilyeu takes center stage to confront one of the biggest questions of our era: can we actually trust the so-called "experts"? Drawing on riveting examples from history and his own journey as an entrepreneur, Tom dissects how expertise has been weaponized by elites, resulting in societal conformity—even when the experts turn out to be wrong. From the smoking doctors of the past to today's battles over pandemics, politics, and public policy, Tom lays out a provocative argument for why blind faith in authority is more hazardous than most realize. Tom invites listeners into a historical deep dive, exposing powerful stories like the persecution of Socrates and Galileo, the belittling of Linus Pauling, and the revolution started by Barry Marshall's rogue experiment. Throughout, he constructs a compelling case for why challenging orthodoxy is not only healthy, but necessary for progress. Whether you consider yourself an expert or a lifelong learner, part 1 will leave you questioning everything you thought you knew about authority, consensus, and truth. SHOWNOTES 00:00 Introduction: Who Do You Trust?03:29 Paradigm Shifts and Scientific Dogma04:05 Vitamin C, Ulcers, and Outsider Breakthroughs05:17 The Wisdom of Knowing Nothing08:43 The Illusion of Seeing All09:57 The Scientific Method vs. Censorship10:43 Maps, Narratives, and Oversimplification14:42 Freedom of Speech, Control, and Tyranny17:16 Experts Are Not Neutral—Protecting Status CHECK OUT OUR SPONSORS Vital Proteins: Get 20% off by going to https://www.vitalproteins.com and entering promo code IMPACT at check out Monarch Money: Use code THEORY at https://monarchmoney.com for 50% off your first year! Shopify: Sign up for your one-dollar-per-month trial period at https://shopify.com/impact iTrust Capital: Use code IMPACTGO when you sign up and fund your account to get a $100 bonus at https://www.itrustcapital.com/tombilyeu Mint Mobile: If you like your money, Mint Mobile is for you. Shop plans at https://mintmobile.com/impact. DISCLAIMER: Upfront payment of $45 for 3-month 5 gigabyte plan required (equivalent to $15/mo.). New customer offer for first 3 months only, then full-price plan options available. Taxes & fees extra. See MINT MOBILE for detail Learn more about your ad choices. Visit megaphone.fm/adchoices
Welcome to Living Well with MS – your go-to podcast for making informed choices to support your health and well-being with MS! In this episode we are pleased to welcome Dr Terry Wahls, a respected clinical professor of medicine, researcher, and someone with lived experience of MS. Diagnosed with secondary progressive MS, Dr Wahls has dedicated her career to exploring the impact of lifestyle interventions on MS and other progressive health conditions. You can learn more about her work at terrywahls.com, or follow her on Instagram @drterrywahls, and on Facebook/Twitter at @TerryWahls. Topics and timestamps 01:30 Meet Dr Terry Wahls: her MS journey and the inspiration for her research. 07:35 Lifestyle and MS what the research really says about improving outcomes. 08:26 Various diets and their impacts on MS. 11:41 The role of dairy and its impact on MS. 13:22 The science of nutrition: what MS studies are missing and why it matters. 15:25 When will neurologists recommend a whole food diet as standard care? 20:16 Real results: practical symptom improvements through lifestyle changes. 24:42 MS in families: understanding risk and tips for reducing it. 27:46 Good stress: and how to harness it to live a longer, healthier life. 31:33 Hope in action: small powerful steps to lifestyle change. Want to learn more about living a full and happy life with multiple sclerosis? Sign up to our newsletter to hear our latest tips. More info and links: Learn about Loren Codain and the Paleo Diet Learn more about Barry Marshall's work Get involved in a study on lifestyle and MS Attend the Dr Talks Multiple Sclerosis and Autoimmune Summit New to Overcoming MS? Visit our introductory page Connect with others following Overcoming MS on the Live Well Hub Visit the Overcoming MS website Don't miss out: Subscribe to this podcast and never miss an episode. Listen to our archive of Living Well with MS here. Make sure you sign up to our newsletter to hear our latest tips and news about living a full and happy life with MS. Feel free to share your comments and suggestions for future guests and episode topics by emailing podcast@overcomingms.org. If you like Living Well with MS, please leave a 5-star review. Support us: If you enjoy this podcast and want to support the ongoing work of Overcoming MS, you can leave a donation here.
Dr. Hoffman continues his conversation with Dr. Kieran Murphy, author of “The Essence of Invention: Medicine and the Joy of Creativity,”
In this episode of the Intelligent Medicine podcast, Dr. Ronald Hoffman interviews Professor Kieran Murphy, an interventional neuro radiologist and prolific inventor from Toronto Western Hospital. Dr. Murphy has developed numerous innovative medical devices and filed 60 patents. He shares insights from his book, “The Essence of Invention: Medicine and the Joy of Creativity,” discussing his work on medical innovation, his unique background, and personal experiences that have driven his creative solutions. The conversation covers various topics, including the importance of creativity, the impact of bureaucracy on modern medicine, and groundbreaking innovations like ozone therapy for herniated discs and a radio-protective supplement for medical personnel. Dr. Murphy emphasizes mindfulness and paying attention to phenomena as key components for fostering creativity and innovation in medicine.
Today in 1951, the birth of Barry Marshall, a Nobel Prize winning doctor who, while working with colleague Robin Warren, proved what was behind most ulcers by giving himself an ulcer. Plus: an 11 year old in England saves an engraving from the dumpster that turns out to be pretty important. The Doctor Who Drank Infectious Broth, Gave Himself an Ulcer, and Solved a Medical Mystery (Discover Magazine) Dürer Engraving Found by 11-Year-Old in Dumpster Sells for $44,000 (Hyperallergic) Keep this podcast healthy as a backer on Patreon --- Support this podcast: https://podcasters.spotify.com/pod/show/coolweirdawesome/support
”I wasn't interested in learning stuff. I was just interested in understanding, because I could see what a fabulous shortcut it always was.” – Meet 2005 medicine laureate Barry Marshall in a dynamic talk with the Nobel Prize's Adam Smith. Marshall tells us about his blog (something very few laureates had in 2005), his status as a yo-yo expert and his research that paved the way to a Nobel Prize. Self-experimentation is another topic that is up for discussion. Marshall takes us back to the moment he drank a bacterial culture of Helicobacter pylori to prove that gastric ulcers were caused by bacterial infections - it's a story you don't want to miss! This conversation was originally presented in February 2014. Hosted on Acast. See acast.com/privacy for more information.
Bumper mailbag! Send stuff to: EEVblog Mailbag PO Box 7949 Norwest NSW 2153 AUSTRALIA 00:00 – Mailbag 00:18 – Barry Marshall, Nobel Prize Winner returns a faulty 121GW
Welcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is: Stomach Ulcers and Dental Cavities, published by Metacelsus on August 6, 2023 on LessWrong. (This is a linkpost from my blog, De Novo) Recently I learned about an effort to prevent dental cavities by using genetically modified bacteria to outcompete cavity-causing bacteria. This got me thinking: why has the idea of preventing cavities by targeting bacteria not been more developed already? The current situation reminds me of the history of stomach ulcers. Before the 1980s, doctors recommended avoiding spicy foods and reducing stress to alleviate stomach ulcers. However, once Robin Warren and Barry Marshall proved ulcers were due to H. pylori infection, treatment with antibiotics to eliminate the bacteria became the standard of treatment. Today, dentists recommend avoiding sugary foods and brushing your teeth to prevent cavities. But we know cavities are caused by bacteria (in particular Streptococcus mutans), so why not directly attack cavity-causing bacteria? Some potential ideas: Selectively targeted antibiotics Vaccines (previously tried in the 1980s, not very successful because it's difficult to get antibodies to penetrate biofilms, and also because S. mutans has several different strains with different antigenic profiles) Outcompeting S. mutans with different bacteria (the current effort by Aaron Silverbook, which I think is promising) Basically, what Aaron Silverbook is proposing to do is recreate a strain of S. mutans, termed BSC3-L1, that is deficient in lactic acid production. This was previously developed by a company called Oragenics, but they abandoned the effort (I think due to financial reasons). It seems Aaron's team is mostly people from software backgrounds, so they would probably appreciate help from any talented microbiologists who happen to be reading this post. In a famous case of self-experimentation, Marshall drank a culture of H. pylori and subsequently developed gastritis. For this work, Warren and Marshall earned the 2005 Nobel in Physiology/Medicine. Thanks for listening. To help us out with The Nonlinear Library or to learn more, please visit nonlinear.org
Link to original articleWelcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is: Stomach Ulcers and Dental Cavities, published by Metacelsus on August 6, 2023 on LessWrong. (This is a linkpost from my blog, De Novo) Recently I learned about an effort to prevent dental cavities by using genetically modified bacteria to outcompete cavity-causing bacteria. This got me thinking: why has the idea of preventing cavities by targeting bacteria not been more developed already? The current situation reminds me of the history of stomach ulcers. Before the 1980s, doctors recommended avoiding spicy foods and reducing stress to alleviate stomach ulcers. However, once Robin Warren and Barry Marshall proved ulcers were due to H. pylori infection, treatment with antibiotics to eliminate the bacteria became the standard of treatment. Today, dentists recommend avoiding sugary foods and brushing your teeth to prevent cavities. But we know cavities are caused by bacteria (in particular Streptococcus mutans), so why not directly attack cavity-causing bacteria? Some potential ideas: Selectively targeted antibiotics Vaccines (previously tried in the 1980s, not very successful because it's difficult to get antibodies to penetrate biofilms, and also because S. mutans has several different strains with different antigenic profiles) Outcompeting S. mutans with different bacteria (the current effort by Aaron Silverbook, which I think is promising) Basically, what Aaron Silverbook is proposing to do is recreate a strain of S. mutans, termed BSC3-L1, that is deficient in lactic acid production. This was previously developed by a company called Oragenics, but they abandoned the effort (I think due to financial reasons). It seems Aaron's team is mostly people from software backgrounds, so they would probably appreciate help from any talented microbiologists who happen to be reading this post. In a famous case of self-experimentation, Marshall drank a culture of H. pylori and subsequently developed gastritis. For this work, Warren and Marshall earned the 2005 Nobel in Physiology/Medicine. Thanks for listening. To help us out with The Nonlinear Library or to learn more, please visit nonlinear.org
Link to original articleWelcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is: Stomach Ulcers and Dental Cavities, published by Metacelsus on August 6, 2023 on LessWrong.(This is a linkpost from my blog, De Novo)Recently I learned about an effort to prevent dental cavities by using genetically modified bacteria to outcompete cavity-causing bacteria. This got me thinking: why has the idea of preventing cavities by targeting bacteria not been more developed already?The current situation reminds me of the history of stomach ulcers. Before the 1980s, doctors recommended avoiding spicy foods and reducing stress to alleviate stomach ulcers. However, once Robin Warren and Barry Marshall proved ulcers were due to H. pylori infection, treatment with antibiotics to eliminate the bacteria became the standard of treatment.Today, dentists recommend avoiding sugary foods and brushing your teeth to prevent cavities. But we know cavities are caused by bacteria (in particular Streptococcus mutans), so why not directly attack cavity-causing bacteria?Some potential ideas:Selectively targeted antibioticsVaccines (previously tried in the 1980s, not very successful because it's difficult to get antibodies to penetrate biofilms, and also because S. mutans has several different strains with different antigenic profiles)Outcompeting S. mutans with different bacteria (the current effort by Aaron Silverbook, which I think is promising)Basically, what Aaron Silverbook is proposing to do is recreate a strain of S. mutans, termed BSC3-L1, that is deficient in lactic acid production. This was previously developed by a company called Oragenics, but they abandoned the effort (I think due to financial reasons). It seems Aaron's team is mostly people from software backgrounds, so they would probably appreciate help from any talented microbiologists who happen to be reading this post.In a famous case of self-experimentation, Marshall drank a culture of H. pylori and subsequently developed gastritis. For this work, Warren and Marshall earned the 2005 Nobel in Physiology/Medicine.Thanks for listening. To help us out with The Nonlinear Library or to learn more, please visit nonlinear.org
The story of ulcer researcher Dr. Barry Marshall and Dr. Strom's music.
Dr. Robert Gaynes, distinguished physician and professor of infectious diseases at Emory University, joins Meet the Microbiologist for the 3rd , and final, episode in a unique 3-part segment, in which we share stories about the life and work of medial pioneers in infectious diseases. Here we discuss the career of Dr. Barry Marshall, the Australian physician who is best known for demonstrating in a rather unorthodox way that peptic ulcers are caused by the bacterium, Helicobacter pylori. Gaynes is author of Germ Theory: Medical Pioneers in Infectious Diseases, the 2nd edition of which will publish in Spring 2023. All 3 scientists highlighted in this special MTM segment are also featured in the upcoming edition of the book.
On today's ID the Future philosopher of science Paul Nelson discusses a new paper in Nature making waves in the scientific community, “Papers and Patents are Becoming Less Disruptive over Time.” According to Michael Park and his fellow researchers, the rate of groundbreaking scientific discoveries is declining while the percentage of consolidating (or incremental) science is coming to dominate. Is the spirit of groundbreaking scientific discovery withering, and if so, why? Nelson notes a 1997 book by John Horgan, The End of Science. Nelson credits Horgan for seeing the trend a generation ahead of the Park paper, but Nelson breaks with Horgan on the diagnosis. Horgan posits that groundbreaking science is declining because we have already made most of the Read More › Source
"Rat Tales" Interview with singer, guitarist, songwriter Barry Marshall from "The Marshalls" & also played with LaVerne Baker. Interview by Mike Hoban Edited by Lenny Scolletta Listen to the "Boston Beat" podcast here: https://anchor.fm/thebostonbeat Listen to the "Rat Tales" podcast here: https://anchor.fm/michael-hoban --- Support this podcast: https://podcasters.spotify.com/pod/show/michael-hoban/support
"Tavern Tales" Barry Marshall Set, Boxboro, MA 2022 Produced & Directed by: Mike Hoban & Lenny Scolletta Interview: Mike Hoban Edited by: Lenny Scolletta Theme written by: Tom Abbott & Lenny Scolletta, performed by The Wayoutz "Rat Tales" Logo designed by: Joe Constantine Special thanks: Medford Community Media (2022) lennyvision --- Support this podcast: https://anchor.fm/michael-hoban/support
Dr. Robert Gaynes, distinguished physician and professor of infectious diseases at Emory University, joins Meet the Microbiologist for a unique episode, in which we share the story of Françoise Barré-Sinoussi, the French, female scientist who discovered HIV and found herself at the heart of one of the most bitter scientific disputes in recent history. Subscribe (free) on Apple Podcasts, Spotify, Google Podcasts, Android, RSS or by email. Ashley's Biggest Takeaways The U.S. Centers for Disease Control and Prevention (CDC)'s Morbidity and Mortality Weekly Report first reported on a cluster of unusual infections in June of 1981, which would become known as AIDS. Evidence suggested that the disease was sexually transmitted and could be transferred via contaminated blood supply and products, as well as contaminated needles, and could be passed from mother to child. All hemophiliacs of this generation acquired AIDS (15,000 in the U.S. alone). The fact that the microbe was small enough to evade filters used to screen the clotting factor given to hemophiliacs indicated that the etiologic agent was a virus. AIDS patients had low counts of T-lymphocytes called CD4 cells. By 1993, the most likely virus candidates included, a relative of hepatitis B virus, some kind of herpes virus or a retrovirus. Howard Temin discovered reverse transcriptase, working with Rous sarcoma in the 50s and 60s. His work upset the Central Dogma of Genetics, and at first people not only did not believe him, but also ridiculed him for this claim. Research conducted by David Baltimore validated Temin's work, and Temin, Baltimore and Renato Dulbecco shared the Nobel Prize for the discovery in 1975. Robert Gallo of the U.S. National Institute of Health (NIH), discovered the first example of a human retrovirus—human T-cell lymphotropic virus (HTLV-1). Françoise Barré-Sinoussi worked on murine retroviruses in a laboratory unit run by Luc Montagnier, where she became very good at isolating retroviruses from culture. In 1982, doctors gave lab Montagnier's lab a sample taken from a with generalized adenopathy, a syndrome that was a precursor to AIDS. Barré-Sinoussi began to detect evidence of reverse transcriptase in cell culture 2 days after the samples were brought to her lab. Barré-Sinoussi and Luc Montagnier were recognized for the discovery of HIV with the 2008 Nobel Prize in Physiology or Medicine. Links for the Episode: From the ancient worlds of Hippocrates and Avicenna to the early 20th century hospitals of Paul Ehrlich and Lillian Wald to the modern-day laboratories of François Barré-Sinoussi and Barry Marshall, Germ Theory brings to life the inspiring stories of medical pioneers whose work helped change the very fabric of our understanding of how we think about and treat infectious diseases. Germ Theory: Medical Pioneers in Infectious Diseases The second edition of Germ Theory, which will include chapters on Françoise Barré-Sinoussi, Barry Marshall and Tony Fauci, will publish in Spring 2023.
Barry Marshall is a Professor of Clinical Microbiology at the University of Western Australia. Alongside Robin Warren, he received the Nobel Prize in Physiology or Medicine in 2005 for first showing that Helicobacter pylori bacteria, rather than acid, were the cause of stomach ulcers. For this, Marshall did a self-experiment where he ingested H.pylori and gave himself acute gastritis, establishing a first link between the infectious agent and the development of gastric disorders. We also embark on (a few) tangents: [00:00] The acid theory of ulcers [09:20] Curiosity-driven research [11:10] Self-experiment ingesting H.pylori [24:15] Non-invasive diagnostics [31:00] Peer-review [40:45] Reproducibility [46:15] Unanswered questions around H.pylori [50:35] Bacteria as vectors [57:45] Inflammation and cancer [1:05:00] The Microbiome Revolution [1:13:20] Charles Darwin [1:18:45] Book recommendations [1:21:10] Karry Mullis Barry Marshall's blog: http://barryjmarshall.blogspot.com Barry Marshall's Nobel Lecture (2005): https://www.nobelprize.org/prizes/medicine/2005/marshall/lecture/ Kary Mullis' Book: Dancing Naked in the Mind Field (1998) Brother Surgeons: Brother Surgeons (1963) Garet Rogers
In this episode, I discuss why the evidence pyramid is a misleading and sometimes an unscientific way to interpret evidence; why anecdote is sometimes right; and why expert opinion is always the final word.Specifically, sometimes systematic reviews and meta-analyses of randomized controlled trials are misleading, either designed improperly or using bad data. An excellent example of this is the Ivermectin systematic review and meta-analysis of randomized controlled trials that purported to show that Ivermectin was a useful treatment for COVID-19 in late 2021. This meta-analysis, published in a reputable journal (PMID 34145166) took the Internet by storm when it was used by Ivermectin promoters to show that Ivermectin was effective for COVID-19. It was later shown to have used fraudulent data (no fault of the paper authors), which biased the results and resulted in false conclusions. This gold standard study design spit out a false result which would have misled countless clinicians and resulted in harm if it had been implemented in clinical practice.This demonstrates that such gold standard study designs cannot be taken at face value. Systematic reviews and meta-analyses are not "gold standard" but rather exist along a continuum of quality.Similarly, anecdotes, such as the one used by Barry Marshall to establish that H. pylori caused gastric ulcers, are sometimes admissible when the rules of causal inference are followed cautiously. Other times they are not admissible, as with many nutrition anecdotes. It depends on the details of the anecdote. At the high-quality end of "anecdotes", we have N-of-1 trials, which are serious scientific tools.What all of this establishes is that "high-quality" methods can sometimes be wrong, and "low-quality" methods can sometimes be preferred. All of these require expert methods to properly evaluate and arrive at appropriate conclusions. There is, in a word, no cookbook approach to science, and all good science ultimately depends on competent expert opinion.
For most of the 20th century, the causes of peptic ulcers were a mystery to scientists and doctors. The most popular theory was that it was a disease caused by stress. The mystery was finally unraveled in the 1980s when Australian physician Barry Marshall deliberately infected himself with the H. Pylori bacteria, got sick, and cured himself with an antibiotic treatment. The discovery that bacteria caused ulcers earned Marshall and his research partner a Nobel Prize in 2005. But why did it take so long to discover the true cause and treatment of ulcers? The answer lies in bad evidence collection methods, medical dogma that caused scientists to fully understand the evidence, and pharmaceutical companies that didn't stand to profit from an antibiotic cure of ulcers. This resulted in many missed opportunities to discover the real cause of ulcers, and countless needlessly suffering patients and even deaths. This is a 10-part series brought to you by the QAA podcast. To get access to all upcoming episodes of Trickle Down as well as a new premium QAA episode every week, go sign up for $5 a month at patreon.com/qanonanonymous Written by Travis View. Theme by Nick Sena (https://nicksenamusic.com). Additional music by Pontus Berghe & Nick Sena. Editing by Corey Klotz. REFERENCES Clendening, Logan (May 7, 1944) Stomach Ulcer Treatment, The Times (Muster, Indiana) Fremont-Smith, Paul (1999) Letter To The Atlantic https://www.theatlantic.com/magazine/archive/1999/05/letters/377612/ Graham, David (2014) History of Helicobacter pylori, duodenal ulcer, gastric ulcer and gastric cancer https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017034/ Marshall, Barry (2005) Nobel Lecture https://www.nobelprize.org/prizes/medicine/2005/marshall/lecture/ Marshall, Barry (2002) Helicobacter Pioneers: Firsthand Accounts from the Scientists who Discovered Helicobacters 1892 - 1982 Palmer, E.D. (1954). Investigation of the gastric mucosa spirochetes of the human. Gastroenterology. White, Peter (2005) Biopsychosocial Medicine: An Integrated Approach to Understanding Illness
Born in Bangor, North Wales and raised in Brighton, Ian Whyte was 7'1" tall by the time he he was 17 years old. Ian always stood out from the crowd. Tall, slim and athletic, little did he know of his future career in the limelight however, Ian endured sometimes savage bullying throughout his school years. After discovering basketball in his teens, he quickly caught the attention of national team scouts who saw his physical attributes and determination as invaluable assets and he quickly progressed to the junior national team ranks. However, Ian lived in fear of being emotionally and creatively expressive for fear of more ridicule, so he was keen to escape school at the earliest possible opportunity. He spent a year at Henry Hudson High School in New Jersey, where he again attracted the attention of basketball scouts, earning sports scholarships to Iona College in New York and Clarion University in Pennsylvania. Ian returned to England in 1994 to play for the London Towers, a new franchise owned by the music promoter Barry Marshall. Still eager to find himself Ian only stayed a season with the Towers, transferring to their rival team across town, The London Leopards. As Europe freely opened its doors to sportsmen and women from across the continent, Ian played for teams across France, Belgium, Greece and Portugal, winning the domestic treble; League, cup and playoff championships with F.C. Porto in 1997. Ian returned to England soon after to play for the Newcastle Eagles, a place that would become his home until his retirement from the game in 2003. Throughout his career Ian tirelessly distinguished himself, representing his country 80 times. In 2003 Ian received a phone call that would change the whole course of his life. By his own admission he was keen to retire on his terms rather than through injury or old age, he responded to a casting call for the new film Alien vs Predator. His success in gaining the role is a matter of history, but personally it was a tremendous victory for him to finally find an outlet for his emotional creativity. Ian was fortunate to work alongside such luminaries as the Oscar winning special effects duo Alec Gillis and Tom Woodruff Jr as well as Oscar winning VFX supervisor John Bruno. He also met soon to be double Oscar winning makeup effects artist Mark Coulier who advised him to get in touch with Nick Dudman, the creature effects supervisor for the Harry Potter franchise. Upon completion of filming on AVP Ian travelled back to England and straight into the world of Harry Potter. Not credited as an actor this time, Ian was hired to help bring to life the character of Madame Maxime played by the sublime Francis De La Tour. Ian worked full time for an entire year on the film, faithfully doubling The character who was the full size 8'6" tall. During this time Ian found himself in great demand, but had to turn down roles on The Hitchhikers guide to the Galaxy and a worldwide tour with Cirque du Soleil. --- Send in a voice message: https://anchor.fm/steven-cuoco/message Support this podcast: https://anchor.fm/steven-cuoco/support
Let's talk about the use of animals in medical research. It's not a subject that people are very comfortable discussing, but we are going to do it anyway.We will start with an incredible story of a fire in Bar Harbor Maine that impacted the health of people all over the world for years, even though they never even knew about it.Then we will ask the question ‘what really causes Ulcers, and how did researchers figure that out?'Dr Wayne Lautt has used animals in his experiments for years. But his approach to it is very different from the mainstream view.These science stories from history help shed light on the modern research being done on Type 2 Diabetes. Specifically, we highlight the work of SciMar as they examine the hormone hepatalin and the effect it has on glucose levels in people who are living with type 2 diabetes. www.SciMar.ca
On est en 1984, à Perth en Australie. Barry Marshall, un gastroentérologue, vient de publier un article sur les recherches qu'il mène avec John Robin Warren. Cette saison, les Grosses Têtes vous proposent de découvrir ou redécouvrir le nouveau podcast de Florian Gazan. Dans "Ah Ouais ?", Florian Gazan répond en une minute chrono à toutes les questions essentielles, existentielles, parfois complètement absurdes, qui vous traversent la tête. Un podcast RTL Originals. Découvrez la page Facebook Officielle des "Grosses Têtes" : https://www.facebook.com/lesgrossestetesrtl/ Retrouvez vos "Grosses Têtes" sur Instagram : https://bit.ly/2hSBiAo Découvrez le compte Twitter Officiel des "Grosses Têtes" : https://bit.ly/2PXSkkz Toutes les vidéos des "Grosses Têtes" sont sur YouTube : https://bit.ly/2DdUyGg
On est en 1984, à Perth en Australie. Barry Marshall, un gastroentérologue, vient de publier un article sur les recherches qu'il mène avec John Robin Warren. Ils y développent la thèse que les ulcères de l'estomac sont provoqués par une bactérie baptisée "Helicobacter". Et que donc un simple antibiotique pourrait les soigner. Dans "Ah Ouais ?", Florian Gazan répond en une minute chrono à toutes les questions essentielles, existentielles, parfois complètement absurdes, qui vous traversent la tête. Un podcast RTL Originals.
This is a recording of the type of critical, candid, yet fun conversation that is also a hands-on expert lesson on how to think creatively with purpose in a distracted world with one of the brightest and creative individuals I have met. I sat down with Jonah Sachs, a true original thinker, marketing executive, speaker, philanthropist, and author of "Unsafe Thinking" and “Winning the Story Wars” who shared his personal perspectives on unlocking creativity with social responsibility and purpose to spread the ideas that matter! Highlights: 04:19 – What inspired you to write “Unsafe Thinking”? Jonah: This book describes my personal journey to answer how I along with my ad agency could re-learn to break the rules once again which is how we had originally become successful. 7:08 – What are some of the ideas that matter to you today? Jonah: I have now moved from marketing to philanthropy and am very concerned as a father about the state of our climate and the ecological crisis we are about to face. 9:19 – Do you have to have a clear vision in order to spread the ideas that matter? 10:04 – Jonah: Scene from “The Matrix” where Neo is tied up and Agents Smith 11:12 – There is a story in your book “Unsafe Thinking” about an expedition to discover the new source of the Nile river that captivated me. What are some of the lessons from it you wanted to convey to the readers? Jonah: In 2005, one adventurer, Cam McLeay and his team navigated the Nile all the way from the mouth to what they call its new source, farther than anyone had ever done. They were expert navigators and included an expert aviator and were able to make their boats fly by attaching wings to their boat to fly over the top of the waterfall. It took one small innovation at a time at every challenge to accomplish this feat. 13:32 – Jonah: Use Fear as Fuel - Mahatma Gandhi case study of learning to embrace and manage his fears. 16:50 – Tim Grover, Michael Jordan's personal coach of many years, and the author of “W1NNING” states that fear teaches you how to win, while doubt merely teaches you what to do in order not to lose. 18:35 – What kind of feedback have you received while touring for your book “Unsafe Thinking” for 2 years globally? Jonah: The most common response is “I would love to take risks but my boss or my company or my clients just will not let me “. We live in a world that constantly rewards conformism so an important lesson I have learned is to be an explorer, not an expert. 21:45 – Jonah: Study of 20,000 so-called recognized “experts” by Philip Tetlock at Berkeley 23:42 – Dr. Barry Marshall's unconventional approach that led to the cure of ulcers and his Nobel prize. 27:37 – Yuval Harrari, a globally renowned lecturer, writer, and history professor from Oxford, says that “our history began when we created Gods and our history will end when we become Gods”. 28:45 – Jonah: Harrari has another fantastic quote – “The Scientific Revolution was kicked off when we started being more interested in what we did not know than in what we know.” 29:33 – Question from the LinkedIn Live Audience: What are your thoughts on tactics for convincing the expert that maybe the newbies/outsiders' ideas are better? Jonah: Shared information bias is a situation in which teams of people gravitate towards what most agree upon. 32:36 – How can we utilize technology in a way to make the ideas that matter go global? Jonah: We consulted Tristan Harris on the famous Netflix movie called “Social Dilemma”, which talks about how we are being manipulated by social media. But distraction may also be a big part of our creativity. 36:35 – Your ideas and dedication to social responsibility is inspiring. As Andy Warhol said, “the idea is not to live forever but to leave ideas that will”. Jonah: Any piece of advice taken to the extremes will lead you to the safe thinking cycle. Listen to the experts, take it all in, and live a varied life of unexpected moments of discovery! --- Support this podcast: https://anchor.fm/alloutcoach/support
In this episode, two longtime best friends throw a murder mystery party: was it a success? Was it a failure? Did Jason discover the murderer only 10 minutes into the party? The boys also discuss their other plans from a big weekend at school. We talk about Dr. Barry Marshall, who may be the most confident guy you will ever hear about. Finally, we cap it off with some juicy hot or nots! Don't forget to follow us on all our social media! --- Support this podcast: https://podcasters.spotify.com/pod/show/twodudesandabench/support
Würdet ihr eine Brühe voller Bakterien trinken? Solche, die euch schaden? In dieser Folge erzählt euch Lorenz, was das Bakterium Helicobacter pylori in unseren Bäuchen treibt und wieso es bis in die 1980er Jahre gedauert hat, bis man das alles beweisen konnte - mittels Selbstversuch des klinischen Forschers Barry Marshall in Australien... seine Strapazen waren nich umsonst: 2005 gab es dafür dann den Nobelpreis für Physiologie oder Medizin. Anschließend wühlt sich Jasmin noch durch den Wikipedia-Artikel über medizinische Selbstversuche und fördert Gruseliges zutage! Übrigens: Damit Bugtales.fm weitergehen kann, brauchen wir dringend eure Unterstützung auf Steady: http://steadyhq.com/bugtales ------ Material Die Presse-Mitteilung des Nobelpreis-Komitees: https://www.nobelprize.org/prizes/medicine/2005/press-release/ Ein Interview mit Barry Marshall: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661189/ Das Buch von Florian Freistetter und Helmut Jungwirth, das auf die Geschichte aufmerksam gemacht hat: https://www.hanser-literaturverlage.de/buch/eine-geschichte-der-welt-in-100-mikroorganismen/978-3-446-27096-1/
Episode 64: H. pylori. Dr Lorenzo explains testing, diagnosis, and treatments for H. pylori, a bacterium that can cause peptic ulcer disease and other complications.By Anabell Lorenzo, MD, and Hector Arreaza, MD. This is Rio Bravo qWeek, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California. Our program is affiliated with UCLA, and it's sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. Today we are going to discuss a topic that may be very basic for many of our listeners, but it is important to check our knowledge foundation to keep building on it. Helicobacter pylori was discovered in 1982 by Barry Marshall and Robin Warren from Australia. They received the Nobel prize in 2005 for their discovery of “the bacterium Helicobacter pylori and its role in gastritis and peptic ulcer disease”. 1. What is H. pylori?It's a gram-negative bacteria found in the stomach causing infection and GI symptoms such as dyspepsia. It is a chronic infection and it's usually acquired in childhood. Incidence and prevalence of H. pylori infection are generally higher in people born outside of North America than among people born here. About 50% of humans are infected by H. pylori in the world. The infection can be life-long and cause no symptoms. The infection can cause peptic ulcers too. 2. When do you test for H. pylori and treat it?Test these patients for H. pylori: -All patients with active peptic ulcer disease (PUD).-Patients with history of PUD (unless previous cure of H. pylori infection has been documented).-Patients diagnosed with low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma.-Patients with a history of endoscopic resection of early gastric cancer (EGC).In a few words, test patients with PUD and stomach malignancies. Controversial indications include:- Consider non-endoscopic test (stool or breath) in patients with unexplained dyspepsia who are younger than 60 years old without red flags.- Patients with typical symptoms of gastroesophageal reflux disease (GERD) who do not have a history of PUD do not need to be tested for H. pylori infection. However, for those who are tested and found to be infected, treatment should be offered, but to the patient that the effects of treatment of H. pylori on GERD symptoms are unpredictable. This means that eradication of H. pylori may or may not affect GERD symptoms. -Patients taking long-term, low-dose aspirin (to reduce the risk of ulcer bleeding)-Prior to initiation of chronic treatment with NSAIDs-Patients with unexplained iron deficiency anemia despite an appropriate evaluation 3. What are the testing options for H. pylori?-In patients is having an EGD, they can be tested with gastric biopsy histology and biopsy urease (best options). Endoscopy biopsy is the best diagnostic test for H. pylori. -In patients who do not require EGD, NONINVASIVE TESTING like STOOL ANTIGEN ASSAY and UREA BREATH TEST are a great option-Before performing the test, it is important to stop PPIs (proton pump inhibitors) for 2-4 weeks and Bismuth/antibiotics use within 4 weeks to avoid false negative results. 4. What ar ethe recommended first-line treatments for H. pylori?Triple therapy: Clarithromycin triple therapy is the recommended option. This treatment includes PPI, clarithromycin, and amoxicillin OR metronidazole for 14 days. This is the recommended in areas where clarithromycin resistance is less than 15%, and in patients with no exposure to macrolides. The two antibiotics and PPI twice a day are given for 2 weeks, and the PPI is continued once daily for one month. PPI may be omeprazole, pantoprazole, or others. Quadruple therapy: Bismuth quadruple therapy consisting of a PPI, bismuth, tetracycline, and a nitro imidazole for 10–14 days is another treatment option. Bismuth quadruple therapy is particularly attractive in patients with any previous macrolide exposure or who are allergic to penicillin. 5. Should we test for H. pylori eradication?Confirmation of eradication should be performed in all patients treated for H. pylori because of increasing antibiotic resistance. There is not a lot of information about antibiotic resistance in the US. The test should be done 4 weeks after completing treatment. 6. What is refractory H. pylori infection? Refractory H. pylori infection is defined by a persistent positive H. pylori test (no serologic), at least 4 weeks after 1 or more full course(s) of a recommended first-line therapy, and when the patient has been off any medications, such as proton-pump inhibitors (PPIs), that may impact the test sensitivity. Refractory H. pylori infection should be differentiated from recurrent infection. A recurrent infection happens when a no serologic test was negative after treatment, then becomes positive again. 7. What tests can be done to evaluate H. pylori antibiotic resistance?We can test for resistance with culture or molecular testing, but these tests are currently not widely available in US. 8. What are the option for salvage therapy after failure of treatment? In patients with persistent H. pylori infection, try to avoid antibiotics that have been previously taken by the patient. Bismuth quadruple therapy or levofloxacin salvage regimens are the preferred treatment options if a patient received a first-line treatment containing clarithromycin. Regimens that contain clarithromycin or levofloxacin are the preferred treatment options if a patient received bismuth quadruple therapy. Rifabutin triple regimen consisting of a PPI, amoxicillin, and rifabutin for 10 days is a suggested salvage regimen. Conclusion:H. pylori is an infection that can be asymptomatic, but it needs to be eradicated if symptoms are present. Detection of H. pylori is fairly easy, but we may need to perform an EGD if patient has red flags. Antibiotics and PPIs are the first line of treatment. Test of cure is recommended for all patients. ____________________________Now we conclude our episode number 64 “H. pylori.” Dr Lorenzo explained when and how to test patients for H. pylori. She explained that patients with GERD symptoms to not need to be tested for H. pylori, but if they are tested and have positive results, then we should eradicate H. pylori. Remember to stop PPIs 2-4 weeks before non-endoscopic tests for H. pylori. Even without trying, every night you go to bed being a little wiser.Thanks for listening to Rio Bravo qWeek. If you have any feedback about this podcast, contact us by email RBresidency@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. This podcast was created with educational purposes only. Visit your primary care physician for additional medical advice. This week we thank Hector Arreaza and Anabell Lorenzo. Audio edition: Suraj Amrutia. See you next week! _____________________References:William D. Chey, Grigorios I. Leontiadis, Colin W. Howden, and Steven F. Moss. ACG Clinical Guideline: Treatment of Helicobacter pylori Infection. Am J Gastroenterol 2017; 112:212–238. https://pubmed.ncbi.nlm.nih.gov/28071659/ Shailja C. Shah, Prasad G. Iyer, and Steven F. Moss. AGA Clinical Practice Update on the Management of Refractory Helicobacter pylori Infection: Expert Review. Gastroenterology 2021;160:1831–1841. https://pubmed.ncbi.nlm.nih.gov/33524402/ J. Thomas Lamont. Treatment regimens for Helicobacter pylori in adults. Up to date, last updated on May, 20, 2021. https://www.uptodate.com/contents/treatment-regimens-for-helicobacter-pylori-in-adults?search=h%20pylori%20treatment&source=search_result&selectedTitle=1~150&usage_type=default&display_rank=1.
The story of ulcer researcher Dr. Barry Marshall and Dr. Strom's music.
The Storycrafters -- the storytelling team of Jeri Burns and Barry Marshall -- share a Nigerian tale in their own inimitable style.
Xin chào các bạn, hôm nay là ngày 11 tháng 6 và hôm nay là ngày gì? SỰ KIỆN 1935 - Nhà phát minh Edwin Armstrong trình diễn công khai đầu tiên về việc phát sóng FM ở Hoa Kỳ tại Alpine, New Jersey . 2008 - Kính viễn vọng không gian tia Gamma Fermi được phóng lên quỹ đạo. 2009 – Manchester United chấp nhận bỏ ra 80 triệu bảng để được mua Cristiano Ronaldo từ Real Madrid 2010 - World Cup lần đầu tiên tổ chức tại châu Phi do Nam Phi đăng cai 2018 - 3 World Trade Center chính thức khai trương. Đây là một tòa nhà chọc trời được xây dựng lại từ tòa nhà World Trade Center cũ bị sụp đổ trong sự kiện 11/9 ở Lower Manhattan. Sinh 1894 - Kiichiro Toyoda, doanh nhân Nhật Bản, là con trai của người sáng lập Toyoda Loom Works - Toyoda Sakichi. Toyoda Kiichiro là người đã đưa quyết định chuyển Toyoda Loom Works sang lĩnh vực sản xuất xe hơi, được coi như là một doanh nhân mạo hiểm ở đúng thời điểm. 1899 - Yasunari Kawabata , tiểu thuyết gia và nhà văn. Ông là tiểu thuyết gia người Nhật đầu tiên và người châu Á thứ ba, sau Rabindranath Tagore (Ấn Độ năm 1913) và Shmuel Yosef Agnon (Israel năm 1966), đoạt Giải Nobel Văn học 1937 - Robin Warren , là nhà nghiên cứu bệnh học người Úc, người đoạt giải Nobel và người được công nhận là người có công trong việc phát hiện lại vi khuẩn Helicobacter pylori hay còn gọi là vi khuẩn HP năm 1979, cùng với Barry Marshall. Mất 1341 – Trần Hiến Tông, hoàng đế thứ sáu của nhà Trần (s. 1319). 1937 - RJ Mitchell , kỹ sư người Anh, người thiết kế dòng thủy phi cơ Supermarine Spitfire (sinh năm 1895) 2008 - Võ Văn Kiệt , tên thật Phan Văn Hòa, bí danh Sáu Dân, là nhà chính trị Việt Nam. Ông làm Thủ tướng Chính phủ thứ tư (trước kia là Chủ tịch Hội đồng Bộ trưởng) của nước Cộng hòa Xã hội Chủ nghĩa Việt Nam từ 8/8/1991 đến 25/9/1997. Ông được nhiều báo chí đánh giá là người đã đẩy mạnh công cuộc Đổi Mới và cải cách chính sách ở Việt Nam kể từ năm 1986, là "tổng công trình sư" nhiều dự án táo bạo của thời kỳ Đổi Mới. 1784 – Lê Quý Đôn, là vị quan thời Lê trung hưng, cũng là nhà thơ và được mệnh danh là "nhà bác học lớn của Việt Nam trong thời phong kiến". #aweektv #ngay11thang6 #vovankiet #lequydon #homnayngaygi #todayinhistory --- Send in a voice message: https://anchor.fm/aweek-tv/message
När den australiensiske läkaren Barry Marshall upptäckte en bakterie som han menade orsakade magsår var det ingen inom det medicinska etablissemanget som trodde honom. De visste redan vad magsår berodde på - stress och andra livsstilsfaktorer. För att bevisa sin tes försökte Barry Marshall infektera djur med bakterien, utan att lyckas. Nästan i desperation, bestämde han sig då för att utföra ett experiment på en människa. Och inte på vilken människa som helst utan på den enda som verkligen kunde ge informerat samtycke om riskerna, nämligen han själv. Emma och Mattias pratar om hur det går till när forskare gör experiment på sig själva och vad det finns för etiska betänkligheter med det. Dessutom har Emma pratat med Gunnar Johanson, professor i toxikologi på Karolinska institutet, om hur han använder sig själv som testperson när han utformar experiment.Berättarröst: Peter ÖbergProducent: Clara Wallin Hosted on Acast. See acast.com/privacy for more information.
Professor Barry Marshall is a physician and 2005 Nobel Laureate in physiology and medicine. Awarded for his, and fellow colleague Dr Warren Robin's discovery of the Helicobacter Pylori bacteria and it's causative relationship with gastritis and peptic ulcers.Barry James Marshall AC FRACP FRS FAA[1][2] (born 30 September 1951) is an Australian physician, Nobel Prize Laureate in Physiology or Medicine, and Professor of Clinical Microbiology at the University of Western Australia. Marshall and Robin Warren showed that the bacterium Helicobacter pylori (H. pylori) plays a major role in causing many peptic ulcers, challenging decades of medical doctrine holding that ulcers were caused primarily by stress, spicy foods, and too much acid. This discovery has allowed for a breakthrough in understanding a causative link between Helicobacter pylori infection and stomach cancer.Find Barry here http://barryjmarshall.blogspot.com/https://twitter.com/barjammarhttps://www.nobelprize.org/prizes/medicine/2005/marshall/lecture/Support the show (https://www.patreon.com/labanditchburn?fan_landing=true)
It's not surprising that an Australian scientist got a Nobel prize for drinking something weird - but how he lined up the ducks to get there, that's the story... Rod tells Will the story of Barry Marshall, Nobel Prize winner! The Wholesome Show is Dr Will Grant and Dr Rod Lamberts, proudly brought to you by The Australian National Centre for the Public Awareness of Science!
Andrew Tran struggled with self-doubt. But Andrew's obsession with instant ramen led him to a scientist who changed his perspective. He learned about Barry Marshall, who discovered the cause of ulcers by taking matters into his own gut.
What happens when the scientist... becomes the subject? We're examining the strange world of self-experimentation, from the history of martyr medics and kooky romantics, to the modern biologists dosing themselves with DIY COVID vaccines in the months after the pandemic began. Plus, is mixing vaccines the best way to fight coronavirus? Scientists capture an elusive element, number 99... and the physics behind why wombats poo in cubes! Like this podcast? Please help us by supporting the Naked Scientists
What happens when the scientist... becomes the subject? We're examining the strange world of self-experimentation, from the history of martyr medics and kooky romantics, to the modern biologists dosing themselves with DIY COVID vaccines in the months after the pandemic began. Plus, is mixing vaccines the best way to fight coronavirus? Scientists capture an elusive element, number 99... and the physics behind why wombats poo in cubes! Like this podcast? Please help us by supporting the Naked Scientists
2021 interview with songwriter, producer, musician and drummer for the Marshalls, Barry Marshall. Barry also played, produced & toured with LaVern Baker. Produced & Directed by: Mike Hoban & Lenny Scolletta Edited by: Lenny Scolletta Theme written by: Tom Abbott & Lenny Scolletta, performed by The Wayoutz "Rat Tales" Logo designed by: Joe Constantine Special thanks: Medford Community Media (2021) lennyvision --- Support this podcast: https://anchor.fm/michael-hoban/support
** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at This Medical Life, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode ** In 1983, Dr Robin Warren and Dr Barry Marshall embarked upon a study to investigate the significance of bacterial found in the stomachs of ulcer patients. This journey would take them over a decade to complete and was riddled with self-doubt, persistent scepticism, and challenging centuries of medical dogma but their persistence ultimately led to the highest accolade in Medicine. Oh, and a bout of bad breath.Helicobacter pylori is a gram-negative bacteria that has evolved with humans. With an estimated worldwide prevalence of up to 50%, this organism has found a survival niche where it is perfectly suited to thrive in the stomach's highly acidic environment. Unfortunately for those of us who have it, it will cause inflammation (gastritis) but can eventually lead to cancer (gastric adenocarcinoma).Our interview is with Professor Barry Marshall who navigates the lows of persistent knockbacks through to the worldwide tour that lead to the Nobel Prize in 2005. Professor Barry MarshallNobel Prize Laureate and Professor of Clinical Microbiology The discovery by Dr Warren and Professor Marshall has benefited millions of people, maybe saving a million lives over the last 10 or 20 years. Barry James Marshall AC FRACP FRS FAA is an Australian physician, Nobel Prize Laureate in Physiology or Medicine, and Professor of Clinical Microbiology at the University of Western Australia. https://www.uwa.edu.au/profile/barry-marshall Additional links of interest: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(05)67587-3/fulltext https://www.science.org.au/learning/general-audience/history/interviews-australian-scientists/professor-barry-marshall/teacher See omnystudio.com/listener for privacy information.
In 1983, Dr Robin Warren and Dr Barry Marshall embarked upon a study to investigate the significance of bacterial found in the stomachs of ulcer patients. This journey would take them over a decade to complete and was riddled with self-doubt, persistent scepticism, and challenging centuries of medical dogma but their persistence ultimately led to the highest accolade in Medicine. Oh, and a bout of bad breath. Helicobacter pylori is a gram-negative bacteria that has evolved with humans. With an estimated worldwide prevalence of up to 50%, this organism has found a survival niche where it is perfectly suited to thrive in the stomach's highly acidic environment. Unfortunately for those of us who have it, it will cause inflammation (gastritis) but can eventually lead to cancer (gastric adenocarcinoma). Our interview is with Professor Barry Marshall who navigates the lows of persistent knockbacks through to the worldwide tour that lead to the Nobel Prize in 2005. Professor Barry Marshall Nobel Prize Laureate and Professor of Clinical Microbiology The discovery by Dr Warren and Professor Marshall has benefited millions of people, maybe saving a million lives over the last 10 or 20 years. Barry James Marshall AC FRACP FRS FAA is an Australian physician, Nobel Prize Laureate in Physiology or Medicine, and Professor of Clinical Microbiology at the University of Western Australia. https://www.uwa.edu.au/profile/barry-marshall Additional links of interest: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(05)67587-3/fulltext https://www.science.org.au/learning/general-audience/history/interviews-australian-scientists/professor-barry-marshall/teacher See omnystudio.com/listener for privacy information.
We always hope that the stories we share with you on The Apple Seed spark memories for you to share with the people that you love. Sometimes those memories are sparked by listening to personal stories, and other times by listening to tall tales and fairy tales. So sit back, relax, and get ready to have the memories wash over you as you listen to stories about life lessons, queen bees, and a drop of honey. On today's episode, enjoy the following:"Passing it On, I: Raised in the Briar Patch" by Betty Ann Wylie from Pass it on: A Storyteller's Journey (9:02) Our first story today acts as a sort of audio essay about what life felt like when Betty Ann Wylie was growing up. It's full of rich detail and we hope that it will bring back picture memories for you of how things were when you were a child, or if you are a child, how you'd like to remember this time that you're living. "Life Lesson from Larry" by Don White from Live at the Guthrie Center (6:46)Don White has survived and been on stage for more than twenty years, eliciting from his audience laughter and tears with his comedic storytelling style. In this story, Don shares some important life lessons he's learned from his father, Larry. "Drop of Honey" by Mary Wright from Mary Wright Stories (6:56) Mary Wright shares a folktale that endeavors to prove that even the smallest events - in this case a drop of honey falling off a grain of rice - can have major consequences. "The Queen Bee" by The Storycrafters from Yarns of the Brothers Grimm (23:24)A story about a drop of honey is a great segue into this next story called "The Queen Bee", told in the inimitable style of The Storycrafters, the husband and wife duo of Barry Marshall and Jeri Burns. It's a quest story that you're sure to enjoy. Radio Family Journal: "Ernie's Hits" (5:35)That questing story from The Storycrafters brings to Sam's mind a memory of going on a "bear hunt" in Elementary School. Did you ever take part in that audience participation song? And this memory leads to another memory about Sam's family's records. Here's another entry in the Radio Family Journal.
We always hope that the stories we share with you on The Apple Seed spark memories for you to share with the people that you love. Sometimes those memories are sparked by listening to personal stories, and other times by listening to tall tales and fairy tales. So sit back, relax, and get ready to have the memories wash over you as you listen to stories about whales, frisbees, and getting older. On today's episode, enjoy the following: "Edith's Lyrebird" by Jackie Kerin (7:06) Every once in a while you may have had a relationship of sorts with an animal that, while not your pet, sort of lives its life in your space to the degree that you understand each other. This story is a reflection upon that kind of relationship, and it's from Jackie Kerin. "How the Whale Got His Throat" by Jim Weiss from A Collection of Just So Stories As Read by Jim Weiss (8:00) This next animal story called "How the Whale Got His Throat" is from Rudyard Kipling's "Just So Stories", so named because the stories Kipling told to his daughter had to be told "Just so". "On Turning a Certain Age" by Susi Wolf from Peeling Life Makes Your Eyes Water (3:42) Here's a little piece from Susi Wolf that's a reflection on turning a certain age. We all hope that with the passage of time we continue to learn. And that message is at the heart of Susi's story. "Dancing Jack" by The Storycrafters from Straw Into Gold (27:06) Up next is the storytelling duo The Storycrafters, Jeri Burns and Barry Marshall, with a piece called "Dancing Jack". It's a musical, rhythmic celebration of story in much the same way it always is when you listen to a great Storycrafters story. Radio Family Journal: "Frisbee with Grandpa" (5:15) Listening to Susi Wolf's reflection on getting older called "On Turning a Certain Age" brings back a memory that Sam would like to share as today's entry in his Radio Family Journal.
Sometimes stories are so new and different from the ones we are used to hearing that we have a hard time understanding their value. We all have to work through a little fear of the unknown, and it takes some practice to see the goodness in new stories. The good news is, we can learn to see the inherent goodness in those stories. The more we listen to new and different tales, the more we consider the different cultural lenses through which people may see those stories, and therefore, the more we learn to love them and their tellers. Even if stories differ from the ones you tell, you can often find their inherent goodness as you listen. Today's stories will explore quirky ideas like a snake's marriage proposal to a woman and even a donkey challenging a toad to a race! Each story may seem a little odd at first, but if you listen for a bit of their inherent goodness, you will hear themes of familial strength and expanded love. Today on The Apple Seed, enjoy the following:"The Woman and the Snake" by Barry Stewart Mann from The Improbable Love of Ethel and Elmer and Other (8:23)Professional actor, writer, and storyteller Barry Stewart Man tells of a girl named Ambala, who can't seem to get rid of her illness. One day, the snake she and her father take care of every day appears to her in a dream, and tells her she will be healed. When she finds herself free of the illness soon after, she begins living a confident life till she is again visited by the snake in another dream. This time, he declares that she will marry him! And so, believing his predictions, she prepares to do just that. Listen in as Barry tells The Woman and the Snake, from his album The Improbable Love of Ethel and Elmer and Other. "The Three Army Surgeons" by Ingrid Nixon from Grimm's with a Twist (8:34)Inspirational speaker and storyteller Ingrid Nixon tells of three army surgeons who were so skilled that they could remove their own body parts and sew them right back on by morning. One day, during their stay at an inn, the surgeons body parts go missing – the inn keeper and his wife find a way to replace their body parts, hoping they will not notice the different when morning comes. Puzzle along to this quirky tale as Ingrid tells The Three Army Surgeons, from her album Grimm's with a Twist. "Donkey and Toad" by The Storycrafters from Classics with a Twist (8:00)Storytelling duo Barry Marshall and Jeri Burns, also known as The Storycrafters, tell of a donkey who would always brag about his long, strong legs as he laughs about his friend Toad's short, stubby ones. Toad enlists his children in helping him win the race, and instructs to jump out at Donkey and sing their ancestral song at him as he passes by. Tune in to the lyrics of this quirky song as The Storycrafters sing along to Donkey and Toad, from their album Classics with a Twist. "The People Who Could Fly" by Kim and Reggie Harris (16:19)Our country is still wrestiling with a history so entangled with the enslavement of fellow human beings. A wealth of stories grew up among those enslaved people. And it's so remarkable that such a persistent thread among those stories is the thread of the mythical ability of the people to fly away to the magical country called "Freedom". This story called "the People Who Could Fly" was recorded live at the Timpanogos Storytelling Festival. "The Little Red Hen" by Donald Davis from Grandma's Lap Stories (8:09)Donald Davis usually enthralls audiences with stories of his youth growing up in the Appalachian Mountains. But he tells traditional tales, too. Like "The Little Red Hen".
We always hope that the stories we share with you on The Apple Seed spark memories for you to share with the people that you love. Sometimes those memories are sparked by listening to personal stories, and other times by listening to tall tales and fairy tales. So sit back, relax, and get ready to have the memories wash over you as you listen to stories about Chicken Little, squash vines, and mulberry bushes. "The Lap/You Are my Sunshine" by Kim Weitkamp from The Lap (17:47)To kick things off today, how about a little something from Kim Weitkamp? A story that illustrates the real, genuine, problem-solving power of a comfortable lap to sit in. Come for the story, stay for the song. "Here We Go 'Round the Mulberry Bush/Chicken Licken and the Fox Hunt" by Betty Ann Wylie from Mother Goose: From Morning Till Night (14:54)Betty Ann Wylie combines the familiar story and song, Chicken Little and Here We Go 'Round the Mulberry Bush, respectively, to create one story sharing experience. And if that's not enough, she'll thrown in the framework of the well-known "Bear Hunt" story. You're sure to enjoy this fun amalgamation. "Take Me By the Hand" by Judith Black from Oops Ma! Stories and Songs of Family Life (2:21)Since we've already had some fun with music in this episode of The Apple Seed, especially music filled with messages of love and notion that you're not alone, here's a song that little siblings or friends might sing about helping each other through the rough spots, even when you might be different from one another. "The Squash Vine" by the Storycrafters from A Tale For All Seasons (15:24)Let's wrap up today with a little adventure called "The Squash Vine" from the husband and wife storytelling team of Jeri Burns and Barry Marshall.
In this podcast episode, we interview Barry Marshall, AC, FRACP, FRS, FAA, the legendary Nobel Laureate who discovered that peptic ulcer disease was caused by the bacteria Helicobacter pylori, not excess acid. Marshall fought for years against the notion that ulcers were caused by acid and finally infected himself with the bacteria and underwent endoscopy to prove his point. His research has saved countless lives, as untreated ulcer disease can lead to gastric cancer. We discuss numerous facets of his life and his pioneering work. Before antimicrobial therapy against Helicobacter, patients suffered for years without the right therapy. Brought to you by Redhill Biopharma, makers of Talicia (omeprazole magnesium, amoxicillin and rifabutin) delayed release capsules. Visit talicia.com for more information, including full prescribing information. Intro :35 About Dr. Marshall :37 The interview 3:30 Tell us about your upbringing. What was your childhood like? 3:38 How did you meet Robin Warren? 6:35 What was your ah-ha moment that made you want to follow it through? 13:11 Brought to you by Redhill Biopharma, makers of Talicia (omeprazole magnesium, amoxicillin and rifabutin) delayed release capsules. Visit talicia.com for more information, including full prescribing information. 40:56 Were you met with skepticism? 41:13 How did you interact with the naysayers at the time? 51:46 What drove you to infect yourself with H. pylori? 1:01:28 What was it like to win the Nobel prize? 1:10:14 What advice do you have for young faculty members or GI fellows embarking on an investigative career? 1:18:18 Thank you, Dr. Marshall 1:22:30 Barry Marshall, AC, FRACP, FRS, FAA, is an Australian physician, Nobel Prize Laureate in Physiology or Medicine, and professor of clinical microbiology at the University of Western Australia. We’d love to hear from you! Send your comments/questions to guttalkpodcast@healio.com. Follow us on Twitter @HealioGastro @sameerkberry @umfoodoc Disclosures: Berry and Chey report no relevant financial disclosures. Healio was unable to confirm relevant financial disclosures for Marshall at the time of publication.
From time to time on The Apple Seed we feature stories with which you're well familiar. However, the tellers we feature usually put their own unique spin on these classics. And today on the show you'll hear several of those stories from Rosie Cutrer, Donna Washington, and the Storycrafters. You'll also some musings from the great storyteller and musician, Andy Offutt Irwin, that will make you chuckle as well as make you think about some of the adventures you've had over the course of your life. We always hope the stories we share on the program spark memories for you that you can share with the people that you love. On today's episode, enjoy the following:"Rumpelstiltskin" by Rosie Cutrer from Mr. Bun and Other Stories (11:40)You've heard his story, you know his name, but the antogonist of this well-known story from Rosie Cutrer wishes you didn't. Rosie Cutrer has been known to pull out a banjo from time to time and pair her delightful stories with energetic music. Here's just one of many such stories. "Three Princes Riding" by Donna Washington from Angel's Laughter (14:50)Like so many great stories passed on over the years, stories can change dramatically with each telling. The wonderful teller, Donna Washington, shares here her version of a story called "Three Princes Riding", written by Nancy Schimmel. And the story begins with a unique problem: Nothing is happening in Fairytale Land. However, you'll discover as the story goes on that there's plenty happening. "Secret Santa" by Andy Offutt-Irwin from Perpetual Calendar (11:41)This next story is a Cub Scout story called "Secret Santa". But it's not so much a Christmas story as it is a delightful tale that will bring back Cub Scout memories for you, if you have them. Here's Andy Offutt Irwin performing live at the International Storytelling Cetner in Jonesborough, TN. "The Cinderella Rap" by The Storycrafters from Tales From Timp 2012 (6:34)Here's a story from the husband and wife storytelling duo, Barry Marshall and Jeri Burns, AKA "The Storycrafters". Their musical, rhythmic tellings of some of the classic tales with which you're familiar put a new spin on some of those tales and you get to hear them as if for the first time. This is a piece called "The Cinderella Rap" performed live at the Timpanogos Storytelling Festival. "The Light Went Away" by Andy Offutt-Irwin from Andy's Wild Amphibian Show (3:16)Earlier you heard a Cub Scout memory from Andy Offutt Irwin. And now to close things off, Andy's back with a lullaby called "The Light Went Away".
Eric Rieger 0:00 Hello It is now time for the gut check project KBMD health fans and those at the Ken Brown clinic. I'm here with my guest host, Dr. Kenneth Brown. We've got an incredible special guest with us here today Dr. Tom O'Brien joins the show. Like and share of course, Dr. Brown once you take it away and introduce our awesome guests. Ken Brown 0:19 Well, I'm so excited because Dr. Tom, you and I have been running in similar circles. And every time I bump into somebody including different lab companies, including different mindshare people, everybody's like, Hey, you and Dr. Tom need to hang out. I'm like, I keep missing him. I'll go on a summit and he'll be like before me or after me. And then I'm just like, Oh, this is awesome. So we finally got you, wrangled in, you've got so much stuff going on. You're an author, you're a doctor, you obviously do some incredible deep dives. And what I love about you is everything that I've seen you on a webinar on a summit is science backed and that's exactly what we do. So I'm just thrilled I I have no agenda for this. You got a ton of information. If we ended up talking about something that I need to learn about, I'm just going to peel off and say, Wait, explain that. And that's, that's for me. So I'm not trying to question you, but like, sure, where I've read some of your stuff. And it's pretty cool. We're talking the same stuff, fix your brain through your gut, that kind of thing. That's all about us. So, welcome. So excited. Dr. Tom O'Brian 1:18 Thank you. Thank you so much. And I'm thinking a place to start if I may. The Alzheimer's Association came out last year and said one out of three elders dies with Alzheimer's or another dementia. So that means between the three of us, one of us is going down in our brain function, and it ain't gonna be me. Ken Brown 1:42 It's gonna be Eric. It's gonna be Eric.Eric Rieger 1:43 This is unfair.Dr. Tom O'Brian 1:44 I feel like I understand. But that's a reality check. And with a reality check like that, whether we like it or nobody likes to talk about brain function, no one does. You know, we all know someone that had a heart attack and survived. They changed their diet, they started exercising, they lost 25 pounds, they look better than they've looked in years. Most of us know someone diagnosed with cancer that went through the recommended protocols. And they're doing better than they've done in years. No one knows anyone diagnosed with a brain deterioration disease that's doing good. It terrifies us. And so we avoid the topic. So I want to talk about first the reality check that our healthcare system is not quite working the way we want it to and more people are getting sicker, especially if we talk about the brain and kids with autism and the numbers are skyrocketing and all that, but how can we look at our health care if our bodies aren't working the way we want them to right now? What's the big picture view of that? How do I get a big picture and I want to suggest this concept because I have found that this works really well. When I moved from Chicago to Southern California in 2010 I needed a map. How do you get from Chicago to San Diego? You need a map, you know, and I may know how to get to Denver cuz you just get on I 80 in Chicago, it takes you to Denver, right? You know, I may or it actually doesn't, it takes you close and you have to go up and 94. But I don't know how to get to San Diego, you need a map. When your body is not working the way you want it to you need a map. You can't just look for a better form of vitamin C, or what brain nutrient Can I take to help my brain function better? We have to have the map and what is the map in healthcare. The map is understanding at a layman's level, how I got to where I am and if we don't. To understand how we got to where we are right now, we are just like a dog chasing its tail trying to get somewhere else. So the question about brain dysfunction, or the question about auto immunity is, why is the immune system attacking my own tissue? Why is my brain not functioning the way it's supposed to, and you have to do a deep dive. And you don't need to be a geek and know the science because there's lots of information out there now. But we have to be willing to be uncomfortable for a little bit of time in being overwhelmed with knowledge. And we take it just one step at a time. That's why the subtitle of my most recent book, you can fix your brain. The subtitle is just one hour a week to the best memory, productivity and sleep you've ever had. And it's not cutesy subtitle It is the only way to be successful at changing the direction your brains going. Because as you learn more and more about the things that you didn't know, you mean that little bit of mold on my shower curtain there, it secretes spores into the air every time I take a shower, and I'm inhaling those spores and they go right up to my brain. And the number one type of Alzheimer's of the five types is called inhalation Alzheimer's, meaning what you're inhaling is causing the inflammation in your brain killing off brain cells. Yes, change shower curtain, you know, or whatever the trigger is. People don't know what the trigger triggers are. So they don't know what to do and they're hoping for a magic pill. You need the map. How did I get to where I am, so you then can make the corrections over six months to a year that turn your health in a new direction.Eric Rieger 6:00 I agree with that. I think that with where you're where you're beginning here in our discussion, many of the things you listed there, there's a lot to unpack, but many of the things that you listed there are, I think some huge tenants that that we discussed here on the go check project. One of those is that gut brain access, Dr. Brown talks quite a bit about the relationship for brain health and how it begins really with systemic health, which obviously originates in the gut. And then you're talking about issues of, of nerves and obviously the brain is a bundle of nerves but neural health and so what is it specifically that we need to do to protect our bodies from I would assume you're getting to long term inflammation what what the caveats are there that are initiating those inflammatory responses? So is there something that you wanted to kind of peek at there were Ken Brown 6:51 Yeah, so love where you're going with this. I'm um, as a gastroenterologist what I'm seeing is an exponential growth of autoimmune disease, Crohn's all sort of colitis are those celiac disease. Those are the ones that I deal with. And we're seeing this huge exponential growth. What you're describing is one in three people getting Alzheimers, we are seeing that autism is increasing. there's a there's a common theme here. And it's this upward hockey stick that's going on with chronic diseases. I love everywhere you're going and you I'm my bandwidth is only so large, where I have to kind of focus on how do I improve your gut to improve your brain and now you're talking other aspects. I want to get into that, but I want to know more about the guy. I'm a real big fan of how I built this. So I want to know more about the guy, the doctor Tom, how did you end up deciding that you were going to go down this path? I've heard a lot of your lectures so I know that you're super smart. I know you're very well read, but I don't know you. So let's talk about you for a moment. Dr. Tom O'Brian 7:52 Sure, sure. When I began my medical education in chiropractic school, very first week, the very first week I knew absolutely nothing. You know, we're working on a cadaver. I've just seen a dead body for the first time learning how to work with cadavers and genetics classes. There was a sign Dr. Sheldon Deal. Mr. Arizona was coming on campus to give a talk on Wednesday night. My very first week. This was the first week of January 1978. And I thought I'll go listen to this guy, Mr. Arizona bodybuilder, he's going to be a healthy guy. So I go to the talk. He has a color television on a stand in the room and back then color televisions were pretty new. And so to see all those colors, you know, he had the television on but the volume offand he walked over to a desk opened his briefcase to pick out a bar man, an iPhone, walked up to the color Television holding the iPhone like a flashlight you know policeman holds a flashlight up Hi, walks up to the color television with this bar magnet, the picture turns upside down and walks away. It goes right side up and walks towards it goes upside down. walks away it goes. Right? In attic pollution does to your brain and your nervous system. It's called neurological switching. These are people that say right, when they mean left, they write the number three backwards. they they they just are confused. And it was the first evidence in my mind the first introduction to electromagnetic pollution Ken Brown 9:51 1978 he was talking about in 1978. That's crazy.Dr. Tom O'Brian 9:55 Yes, because he he was talking he was talking about batteries in a watch and because they were fairly new, and when you put a battery next year body and this was a watch that it can for sensitive people, not for everyone but for sensitive people. It can be the straw that breaks the camel's back. And it impacts on their neurological organization, and how their their brain and their nervous system functions. Nowadays, we take it for granted Of course, we wear watches with batteries, and we put ear pods and our years we put batteries next to our brain. And, you know, we're using headphones that are remote wireless, so more batteries next to the brain. You know, I'm a strong advocate that we never put a cell phone next to our head. You either use the speaker or you use a corded earphones so that you're not putting especially for children whose skulls are thinner and these electric magnetic waves penetrate through a thinner skull of a child. And now there are so many studies on that. That's why in the book, you can fix your brain. I talked about the pyramid of health. Remember, we're still looking for a map here. How did I get to where I am? So in a pyramid, we think there's three sides to a pyramid. No, there's four. There's also a base. So the base is structure. That's the home of chiropractic and osteopathy, and massage and pillows and orthotics in your shoes and is your car seat tilted back. So you're driving like this all the time. That's, that's structured the base, then there's the biochemistry, the one that we all know about. And that's what we eat and drink the air we breathe. Then there's the spiritual or emotional and then there's the electromagnetic. So whenever you have a health concern, you have to look at all four venues to see, where are the triggers that are contributing to my body not functioning the way it should. So that was my introduction in January of 1978, to healthcare. And from that, I started looking in the literature and I found some children living within a quarter mile of high power tension wires had higher incidences of leukemia. That was 1979. I think I found that first study. And by the early 80s, mid 80s, there are many studies coming out about high power tension wires, and people's health if they live near that. So that validated for me, that for some people, electromagnetic pollution was a problem. Not for everybody, but for some people. And the same is true about structure. For some people. That's the problem. For some people, it's stinking thinking, the emotional or spiritual side and You can see the studies on stress hormones inflaming or triggering type one diabetes and triggering autoimmune diseases was what we think that or how we respond to stress and the hormones we make that set that up. For some people. That's the trigger. It's all about finding the map. So my entire career has been based on always asking my first mentor, no, my second mentor. My second mentor was Dr. George Goodheart, the founder of applied kinesiology, the muscle testing that some doctors have seen. Practice night have hundreds and hundreds of hours with Dr. George and he would always every weekend in our seminars, and usually they were at the Marriott Hotel at the airport in Detroit. So people fly in from all over the world to listen to Dr. George and the the podium that he's stood on was a wood podium. And he would do this all the time. He would say, lift up his right knee and his right arm and go, Why doctor and slam his foot down really hard. So we all kind of jumped in our seats now, because that would stage would just like bounce a little bit. Why do they have what they have? Why is your patient complaining of dot dot dot? And he would consistently drill into us Why? So my entire career has been based on why is that happening? You know, for example, why is it? We've all heard that it takes 20 minutes before the hormones in your gut. Tell your brain that you've eaten enough? How come you don't feel full right away with the volume of food you take in? How come you have you eat a little bit more and they say, Oh, I'm really full. How come that messaging is delay. I don't really know. But doctor Ken , you might, you know, we could have some discussion about this. I just made this up. But I think it's because we have the same body as our ancestors thousands and thousands of years ago, bodies function exactly the same. And a primary concern for our ancestors was getting enough food. They didn't get three meals a day, they ate when they found food. So even when they're full, maybe they should eat a little bit more because they might not get it next time. And so they get an extra few 15-20 minutes of eating the berries or eating the nuts or a little more meat on a harvest they made because they might not get a meal for a day or two. And I'm just making it up as to why I've never seen anyone write about why that is that that happens. But that's that was my thought about it, but always why. So I've been asking why my entire career.Ken Brown 16:01 So the why this is really interesting. So the when was 1978? The How is these mentors that have come to you? And then the Why is how do I do this? So then the how I built this, where did you go from? Okay? I am learning a lot from these experts, I have decided to shift my career focus and put in you've put a ton of time into developing summits into writing books into I mean, your your website is just got blogs that are just stacks and stacks deep. So when did you make this decision to go, I'm going to really commit to this aspect. And I'm going to become a thought leader and a teacher about these kind of things. Because clearly, you're passionate. But the as, as a physician myself, it's finding that time it's saying I'm going to take this, this leap off this dock, say I'm going to commit to this. I feel so strongly about it that I'm willing to put myself out there.Dr. Tom O'Brian 17:01 My third mentor was Dr. Jeffrey Bland. Who I heard Dr. Bland first talk in Chicago in 1978. And he is the Science Guy. Ken Brown 17:15 78 was a big year for you.Dr. Tom O'Brian 17:16 It was a big year. It was a very big year, married in 77. Went to school graduate school in 78. met these incredible mentors. You know, I think my angels just guided me to these guys. It was unbelievable. And but Dr. bland would say now this doctor in the New England Journal of Medicine said this and oh here three years ago, in the British Medical Journal, they said this and right here last week in the Journal of American Medical Association, they've said this, do you see how these pieces come together? And Dr. bland has always been about asking why and understanding at a deeper level why things can occur from a science level. So Dr. Goodhart was all about clinicians and being a clinician and finding out how things work. And sometimes he made up the reasons because he wasn't as much of a science guy, as Dr. bland. so bland is talking why from the science goodheart is talking why from the results. And so what happened? Was I just with every patient, I just kept looking to see, why is that happening? Or if they're not getting the results that I think they should have gotten? Why is that not happening? What am I missing here? What am I missing? And so I kept I keep looking and looking and looking. I'm not content when they feel better. And I mean this with the greatest of respect, I don't really care how they feel. They don't come. They come to me because of how they feel. But they're really coming to me to have their bodies function better so they live a long and vital life and how they feel is transient. So whether I get them feeling better right away is secondary to identifying the mechanism behind why their body's not functioning properly, Ken Brown 19:11 love how you said that, so that how they feel is transient. And the first thing I thought of is how many people come to me. And they're on multiple anxiolytics and multiple antidepressants, right? And I read the notes from the other doctors and they're like patient reports of feeling less anxious. Plus, check. Beautiful, there it is. But now I'm dealing with side effects of eight different drugs. And so I like how you said that how you feel is transient. I need to know why. I love Dr. Tom O'Brian 19:38 Yeah, yeah, and of course, all of these drugs, the antidepressants, the anti anxiolytics. They're all approved and designed to be used for a short period of time. None of them are approved for the rest of your life. But they're given to people so they continue to feel less symptoms. Ken Brown 19:56 They're approved to be given for short periods of time, but the pharmaceutical and I'm not passing the pharmaceutical industry. Many of these drugs if you try and get off of them create a tremendous amount of their own side effects. So knowing that, so Eric Eric's former life, the way that he paid for his crna school was actually as a drug Rep. So he's got some pretty interesting stories about how to make sure that you move some product.Eric Rieger 20:19 Yeah, no comment, but I don't work there anymore. So that's probably the most important takeaway. No, but I do agree with that. And I do think Dr. Tom, one of the biggest issues that I never liked about certain aspects of pharmaceuticals, which were intended for short term, to become long term is they're missing a very, very important piece. Once I've taken this to alleviate whatever the symptom or the feel, as you put it, there's no exit strategy. There's no way for me to break this dependency that I've now formulated to make me now feel this new normal. And that's, that's something to fear. I would, I think, to engage long term with a pharmaceutical that's just simply going to function as a feeling band aid. is taking care of the issue.Dr. Tom O'Brian 21:02 You're absolutely right. You know, and we've got so many cases of people on high blood pressure medication or on antidepressants. And we always say at the very beginning, now look, here's what's going to happen. There are some side effects to the medications you're taking. And you may have heard some, but I'm just want to make sure you know, these are the potential side effects. But we're going to address why your body has high blood pressure right now. So it's great to be taking these medications. You absolutely take them when you need them, and you need them right now. But as we address the underlying why your need for those medications is likely to go down, which means you're going to stand up and you're going to start getting dizzy because your blood pressure is too low, because you've got too much medication now. So I want you to call your cardiologist or the doctor who put you on that medication as soon as you start noticing any symptoms like this, this, this or this and say, Hey, I'd like to come in, and you come in and you say, you know, I'm getting a little lightheaded when I stand up now, and I never did before, but I've changed my diet. I'm exercising, I think I need less medication. Can you monitor me and we meet down when you think it's appropriate and safe. But just gradually wean me down so that I don't have any complications as my body's getting healthier. And every doctor is willing to do that every doctor and if they're not find a new doctor to monitor your medications.Ken Brown 22:36 So I'll stop you right there. And this is more for teaching me and with your style of practice. You have somebody that comes in you know that they've got the diabesity triad or whatever. And you look at them you go Okay, we need to start someplace. Do you start diet do you start environmental toxin do you start sleep, because I think those are kind of the three pillars might leave least knowledgeable aspect of that is environmental toxin because it's just something that I've not gotten into yet. And when you mentioned the breathing in the spores, I'm like, Yeah, I've got a lot of patients that got really sick when they moved into an older home and they renovated and then they've never been right. Since I've definitely believe that mold has a big role, but it's just the amount of time. So when you look at this, I'm challenging you to say this is where I start first, where is it? Dr. Tom O'Brian 23:25 Really easy, really easy. There is a great program that's been developed called the living matrix. And the living matrix is a, I don't know 30-40 page questionnaires. And it's going to take you, Mrs. patient, it's going to take you a day or two to fill this out. You'll come back to it and fill out some more of it. Someone's going to say how is the health of your mother during your pregnant pregnancy with you? And he will say, Oh, I don't know my mother passed. That's all right. Call your aunts. Call your aunts and find out. Did mom take any medications during the pregnancy with me, you get as much information as you can, and when you have a completed living matrix, this is the computer model, the program sets it off into eight different categories. And it becomes obvious which categories are the most out of balance. And that's usually the place that you start. And we'll start with maybe two or three of those categories, depending on the individual. Some people, it's clear, their auto immunity happened within three months of their divorce, or within three months of being sexually abused. And it's clear, they've got to deal with that energy. And so that person needs to include in their protocol, a therapist that they feel really good working with about this particular topic, because that's not my category. But if it's not address, it's going to thwart the progress radically. Ken Brown 24:59 That is so interesting. That's that insult to injury that I have to have that discussion with so many patients where I have somebody that comes to see me and they're like, yeah, it's unfortunate. I went to this horrible divorce. And then I started bleeding out my rectum and then I diagnosed them with raging ulcerative colitis. So like, what is the bad luck? I'm like, I hate to attribute it to bad luck. I attribute it to a sequence of events. Dr. Tom O'Brian 25:22 Yeah, exactly. Right. I agree. Yeah, that is totally agree fully agree. And and the tool called the living matrix of every patient fills that out. I have lots of people, you know, we we did a docu series called betrayal, the autoimmune disease solution. They're not telling you is that out yet? Okay. It is it is. And we've actually had over 600,000 people watch it. When I make the living matrix available to people and I think probably four to 6000 people have filled it out. You know, it's great because it's hard to read until you understand how it works, but it gives you a lot of information. And all of our patients fill it out before I'll ever see them if they don't fill it out, or they fill it out halfway. I don't see them. If I if I see that it's only half done. I call my staff because I'm virtual now, you know, so I do virtual consultations. But as I'm looking at the results here, and I'm looking at the screen and living matrix, you know, if it's not filled out, I call my staff and I say rescheduled or they put the time and I'm not putting the time in until they do if they do it half ass, I'm not going to do it half ass, and so cancel them, and don't charge them just cancel them. And if they want to come back, do it right. You know, you just don't put up with that. And I talk on stage all the time to doctors. You can't put up with someone who's putting their toe in the water. They're either going to do a deep dive with you, whatever your skill set is or they're not and in our practice, we represent that our goal is to help them see the map of what's happened to them. And so if they can't, they can't see the map. If I don't know the history, it's not possible.Eric Rieger 27:16 Well, that's actually pretty, pretty impressive because in a different in a different way when we've had patients who've come through the clinic, and then we've, we've prepped them to, to scope and I'm addressing anesthesia and of course, Dr. Ken over here is discussing with them what to expect as they continue on their journey. Something I've heard him address is, it doesn't matter necessarily what led to where you are right now, whether it be your fault and all of them or none of them. But it is your responsibility to engage with the change that's going to make you better. And you've had that conversation with with plenty of patients and it really just doesn't matter what to this point we can identify the triggers, which of course helps finding the solution. But ultimately, there's going to be self responsibility for one's own health. And you've got to be able to commit to whatever that change happens to be. And I would say that really the the gut check project that this whole the whole reason for this podcast was, we felt that there are better solutions than just taking the old didactics from the pharmaceutical industry and antiquated medic medical school iidx to solve problems. Mother Nature has lots and lots and lots of tools that we don't all, you know, use which are free available. And if you just have the discipline to stick with it for your own interest, you'll find in most cases, a better health, healthy living style, I guess you could say, Dr. Tom O'Brian 28:48 well, you guys are in a unique situation that you have to do the tests to identify where they're currently at. You've got to be able to clearly say you've got ulcerative colitis, it's at this stage and it's in this area of your colon and Okay, so we need to calm down this fire, calm down this inflammation while we look to see where it came from. So you you guys have both areas that you have to address and I do this on stage a lot and you know doctors laugh at it, but I've had a number of people come back to me years later and thanked me that they implemented this. When I I tell patients that my favorite patients are the ones that say I've been to Mayo Clinic and they don't know what's wrong. And I'll say that's great. Congratulations. And they look at me kind of startled. You know, they heard I'm a nutcase. But Congratulations, that means you don't have a disease. Because if you've got a disease, Mayo Clinic would find it. You've got dysfunction, something's not functioning right. So the test we're going to do or not the same test that we're looking for disease, we're going to do functional tests. And I hope that we find some functional tests, and people will and sometimes their insurance won't pay for it. And then some patients will say, Well, I can't afford that. And I say, Okay. Oh, okay. And then I write down in their file. Patient refuses this recommended test due to finances? And please sign this. Well, why? Why would I sign that? Because you're asking me to work with one hand behind my back. And I'm going to do everything I can to be of service to you. I will do my very best, but I'm not responsible anymore. If a problem occurs that I miss something, because well, no, no, that's okay, Doc, I'll sign it. Okay. Or no, no, no, I'll do the test. I'll do the test. Okay, good. Because I've seen so many people that say I can afford it. And two months later, I see him in the shopping they've got a deep tan because they just spent three weeks in Mexico, on vacation. It's just a priority thing. And if someone really can't afford what they need, well, our services will always reduce our services for finances if it's true, but we need patients to take ownership and responsibility to be actively involved with us. as we're going through this process. Ken Brown 31:28 When you started this, you open with Alzheimer's and it's funny because I kind of do that with my patients where you said that one in three people will now develop Alzheimer's. And then you tell me Alzheimers Association says that Alzheimers Association, so and then you talk about a patient that cannot afford to do X, Y and Z but you see them with a deep tan. So I use the let's fix your gut to protect your brain later in life. Because I'm I personally and I try and teach my kids this. I've got a 15 year old, a 13 year old. And my wife and I are on the same page where I personally prefer to purchase memories, as opposed to things. So I'm perfectly willing to take us on a trip, have some incredible meals, have some great pictures that we'll revisit. And rather than purchase something else, and what I mean by that is what is that memory worth? That memory is worth so much more than that object to me. And then if you were to say that I'm going to take away all those memories, meaning I'm going to take away your life, that's the panic moment with me, that's when I want to sit there and say, I want you to change your diet, I want you to change your lifestyle, not even so much is it so much a physical thing. It's not so much so that you can have the Beachbody, it's not so much you can do this. It's so that we protect your brain later. It's so that the same concept of osteoporosis prevention in your 30s so that we're not dealing with it and you're 60 so you're not busting a hip in your late 60s. And then now thing, what you're talking about, it's so true that you, it's hard to get people to think big picture like that. But you've always done this. So 1978 you have these mentors that do this. When did you decide to really say I'm going to be part of the movement? And I'm going to develop this website? I'm going to spend, I mean, you've been prolific. You've written books, you lectured you do some crazy summits. Man, you're gluten summit. Some of the people you have on that are like my heroes. I mean, Alessio Fasano, I mean, I've been following that cat since you know, early on in his career and a lot of you get some some pretty heavy hitters. That's pretty impressive. How did you go from, I now need to make a difference. On a greater scale, I guess is what I'm saying. You've mentioned multiple stages and stuff like that. When did you go it's less from one to one it's more from one to many.Dr. Tom O'Brian 33:53 January 2013 my friend, I think our friend I believe, you know, JJ Virgin. I've known JJ for many, many years. And she used to call me or I'd see her and she said, I just went to this weekend seminar was fabulous. You know, they're talking about this marketing concept of how to get information out to people in sales. He she said, You should come and say, Oh, yeah, thanks. Thanks. And then she hired a consultant, Allie, and he called me and said, I just signed the contract and I'm working with Allie. I'm gonna learn how to do this at a bigger scale. Come do it with me. Yeah, how much? $10,000 it ain't happening here. It ain't happening. Right. And then JJ grew and she grew. She applied to Princeton. Ken Brown 34:45 JJ is pretty convincing. when she gets passionate predicaments. Dr. Tom O'Brian 34:49 Yeah. And then she called me and said, Look, I'm having a seminar. I'm having I'm hosting a seminar, you're going to be there. I'm going to hire somebody to come grab you by the nape of your neck and bring okay, okay. Okay, welcome. So this is January 2013, dropped my jaw to hear how the participants there would do one thing that they prepare a webinar or something. And they would have 200 people attend, or 400 people attend just drop my jaw of the impact factor that was magnified by learning how to use the internet. And so I made a declaration that weekend. I said, you know, I'm a geek, and I just read a lot of science and I know these guys are I've been in their seminars where I've seen them at symposiums. I'm going to interview a number of geeks from around the world. And I'm going to put it online. Would you everyone here in the audience helps support me in this by send out announcements. And they all said yes. So my first interview, you'll really appreciate this Dr. Ken. My very first interview ever was Professor Michael Marsh, and our the marsh Godfather, the Godfather, celiac Marsh one Marsh to Marsh three, the Godfather, and he and no one had ever interviewed him. He was 74 no one had ever interviewed and he took me by the arm and walked me around Oxford and said, Tom, that's, that's right, right where I stood, and that and I received my medical degree in 1962. So that's great professor or took me down in the bowels of the library from the 1800s and that's where he sat to study every day. And you know, so Marsh, the Godfather and Professor Fasano, Harvard and so many others from around the world. Umberto Volta chairs the celiac Society of Italy. And I interviewed all these people. And everyone who's a JJ's event, sent announcements out to their people. We had 118,000 people attend Luton summit in November of 2013. It was the first online. The first online health summit ever was the gluten summit. And we made it up. Ken Brown 37:25 And that was when 2000 what? Dr. Tom O'Brian 37:27 November 2013. Ken Brown 37:30 I mean, thousand of those people were still doing dial up. Yeah.Dr. Tom O'Brian 37:35 That's right, you know, and the weekend I came back from making that declaration, I mean, I was fired up. I get a message. And this guy emails me and says, Hi, my name is Bob Roth. I am the social media director for the University of Chicago celiac center, and I'm out in California. I'm wondering if you did have time for breakfast, and I said, You i'm sure so we had breakfast and Bob said, you know, Dr. O'Brien, everyone's University Chicago thinks you're a nutcase. You talk about you talk about gluten sensitivity outside of celiac disease. And but I watched one of your presentations was recorded, and you're just talking science. I said, Yes. You said, you're actually correct. And I said, I know. I know. He's and I said, Listen, Bob, I just made this declaration. I'm going to do this thing. I'm going to travel the world. I'm going to interview these guys. I know who to interview. And I'm going to interview them. We're going to put it together and we're going to do this thing online. Come join us. So Bob left the University of Chicago celiac center, and came to Southern California and was our social media person. And then we found a guy to who knew how to run this program I learned about in jjs weekend called InfusionSoft, which puts puts all the data together into one package and sends it online. And we hired Bobby from Tennessee. And we put on the gluten summit. And the next day, I mean, so many of my friends call him said, How did you do that? What did you do people like Deanna Minik and Mark Hyman and so many other my friends, how did you do that? And I said, Well, my friends helped me here. And they said, Oh, can can are my staff and we just made it up. When there was a problem. We made it up. And they said, can I talk to your staff. And I said, Sure. Then my staff came to me and said, Hey, Doc, they they want us to do this for them. We should start a company to do this. And I know man, that's not my thing. That's not my passion. You guys go ahead if you want to. That was the formation of health talks online which is hosted 10s of millions of people in the last seven years in different summits all over the world, they of course, that's where it came from.Eric Rieger 40:09 Sorry about that. I didn't mean to talk over you. But of course, you wanted to have people that were interested in what it was that you were offering. You also find some inspiration in the fact that there were that many like minded people who were essentially as you probably assumed, but now you confirm they're kind of starved for that information.Dr. Tom O'Brian 40:27 Oh, I knew I knew from the day I opened my practice about the frequency of weed related disorders outside of celiac disease. I knew it. The testing was just not accurate enough at the time to confirm it. But I put people on gluten free diets and they get better again and again and again. But it was a component of a treatment program, not just gluten free diet, but it was a prerequisite you have to do that. Sure, guys, I see that the battery on my computer's at 5%. I have to run into the other room and get the charger So I'm going to come right back to you. SoKen Brown 41:04 we're gonna love this. I love this conversation. So what's really cool about Dr. Tom is just how honest he's being. He's just like, Hey, I met this guy. He taught me something. I met this other guy. He taught me something, I met this, JJ comes up to me and says, Hey, come over and do this, and just pulls the trigger and says, I have a message that I interview out there. And the digital marketing era was really in full swing. Right then.Eric Rieger 41:30 the thing I felt the reason why I asked Darshan that last question was, to me it was it was eye opening, even when we met JJ is just seeing how many people were now gaining access to topics that simply were not being addressed when when we were young, or going through school, etc. And basically what I feel like Dr. Tom just illustrated here is technology has allowed us to take what has been either ignored or hidden messages out to the masses and then helping people where they couldn't find help before. Ken Brown 41:59 Yeah. Are you back with a Tom?Dr. Tom O'Brian 42:02 I'm back with you. And as, as, as you were talking about technology absolutely correct, you know, for years and years that they thought I was a nutcase because I would talk about wheat related disorders outside of celiac. And now we have the testing available that's very, very accurate 97 to 99%, sensitive and specific. And so with those kinds of tests, the test is called the wheat Zoomer, could you zoom in on problem? And with those kinds of testing, people see for themselves that their immune system is trying to protect them, whether they get sick when they eat it or not.Ken Brown 42:43 So you've said this three times now, which means that it has clearly been a part of your career you said they said I'm a nutcase. They said I'm a nutcase. They knew I was a nutcase. So you've stuck by this, but will you explain a little bit when you say that, they say I was a nutcase. That meant that as a chiropractor discussing these other aspects infringing on people's territory, was it that you were just so far ahead of the curve that nobody was discussing? I want to know why you feel why you Dr. Tom feels that other people viewed you as a nutcase?Dr. Tom O'Brian 43:20 Oh, it was obvious. It was spoken about. But the the point in that is, you know, when when you know, that science is on your side, but technology just hasn't caught up yet to confirm it. And you know, it's on your side, because you see the results again, and again, and again and again, and you keep seeing the results, but you the technology just hadn't caught up yet. Then either you go by the status quo, with all of these unexplained applications, and people Don't get well, they're the way they're supposed to, or are you willing to break new ground and say, you know, oh, no, as is negative, when they give up wheat, they feel so much better. Why don't you try it for three weeks, and let's see what happens. Well then, and they get better. Their their child's attention deficit gets better. And the teacher say the new drug, you've given your child's working really well. And it was just a gluten free diet. The other parents say, Oh, we, we didn't give them any drugs. So he's on a gluten free diet. And you see that again and again and again. I can't let what other people think of me get in the way of the service that I can do for my patients.Ken Brown 44:50 Because you took a really bold let's, let's dissect what you just set about that. You knew that certain people in health care, we're not saying the nicest things about you. And then you dove in when you said I don't want to treat a patient that just sticks their toe in the water, you dove into a digital marketing world where keyboard warriors love to play also. So you went from I know that some people are going to say not nice things, too, I'm going to embrace it on a level that nobody ever has. And I'm gonna teach online, which is a very, very bold thing, because not a lot of people have the guts to do that right. To be pushing the envelope. I mean, it's, you know, I mean, you talk about I've been talking about zonulin for years before we test it. And you said we'd Zoomer and that's how I got involved with vibrant wellness. I was like, Ah, you guys figured out how to check zonulin? Yes,Dr. Tom O'Brian 45:49 yes, yes.Ken Brown 45:51 Yeah. And when I talked to my colleagues, I mean, even when I talked to gastroenterologists, they looked at me like you're What are you? Are you one of those? nutjobs talking leaky gut. You're one of those weirdos talking gluten sensitivity. Um, you know, fortunately, I fortunately did not discover the internet early enough so I didn't have to put myself out there and have a successful career writing books and doing stuff like that. Fortunately, I still have to stick my finger in people's butts to make a living and occasionally interview somebody who's smarter than me that decided to put it out there on the internet and do things and do summit so that's a but it takes guts to do that. So are you there. Dr. Tom?Eric Rieger 46:35 Did he freezeDr. Tom O'Brian 46:37 sn Ken Brown 46:38 you froze there for a little bit.Eric Rieger 46:41 We can hear you. Okay. You guys go. How about that?Ken Brown 46:45 Okay. There we go. Okay, back now.Dr. Tom O'Brian 46:47 Okay. Yeah, sorry. Yeah, you're absolutely right. You know, you asked me why and how did I do this? A home that I have in every one of treatment rooms. Can Can you hear me? Okay?Ken Brown 47:13 Yeah, you're going in and out a little bit, but I think it's all right. Oh, we should go ahead and muscle through it. That's right.Dr. Tom O'Brian 47:19 Okay, okay. There's a poem that I when I read it I just resonated deep deep in my being. It's by George Bernard Shaw. This is the true joy in life, being used for purpose recognized as the Mighty One. The being a force of nature. Instead of a selfish, feverish little clod of ailments and grievances complaining The world will not devote itself to making you happy. I am of the opinion that my life belongs to the whole and it is my privilege to do for whatever I can, life is no brief candle to me. It's sort of a splendid torch that I have a hold up for the moment and want to make burn as brightly as possible before passing it on to future generations. So that's my creed.Ken Brown 48:18 I love it. I love it. It's awesome.Dr. Tom O'Brian 48:20 And and from that place, if you know about zonulin, and you know about leaky gut and you think a patient's got it and you don't address it, because of what our peers may think, in my mind, it's Shame on you. And I do that on stage with doctors all the time, who cares what your peers think? I'll give you an example of that one, and you'll appreciate this one 1986 Australia. gastroenterologist says, You know, I think that sometimes ulcers are caused by a batch said you are a nutcase. Everybody knows ulcers are caused by too much acid and you have to give antacids so what did this guy do? He does an endoscopy, puts a camera down into his stomach takes pictures of the healthy pink tissue of his stomach. And then he drinks a beaker of beaker of a bacteria called Helio backer pylori. waits for days until he's as sick as can be, does another endoscopy takes pictures of the many ulcers that are starting in his stomach, and then he takes the antibiotics to kill the bacteria waits about a week until he's feeling better, does another picture of the healing of the ulcers. Then he publishes that paper, then everybody knows he's a nutcase. But he proved the under shadow of a doubt sometimes, ulcers are caused by a bacteria and the World Health or I thought that was so important. They sent that paper to every medical society on the planet. Why? Because at that time, stomach cancer was the number one cancer killing people. And it often comes from a helium backdoor infection. So, this guy didn't care. You know, he didn't care. He done his work, and he still was kind of thought of as a weirdo out there. Dr. Barry Marshall. 21 years later, he wins a Nobel Prize in Physiology. And the Nobel committee says and this is the exact quote, who with tenacity, and a prepared mind challenged prevailing dogma and that's what every one of our patients needs.Ken Brown 50:49 a prepared mind. I like that exact word mind if you if you're tenacious, but you do your homework, you burn the midnight oil, the prepared mind with tenacity is an unstoppable force. That's awesome. That's love thatDr. Tom O'Brian 51:05 is just one hour a week. That's tenacity every Tuesday night after dinner every Sunday morning after services whenever it is, but every week, you're going to spend one hour learning more about reading the map of how you got to where you are just one hour a week. And in six months, you've changed the way you think you change the way you live your life. You challenge prevailing dogma, and your health is the benefit that you get from it.Eric Rieger 51:34 I love that. Ken Brown 51:35 I love it. IEric Rieger 51:36 mean, it's interesting that you use Marsh as that example, because when this guy sitting to the right of me developed Atrantil and went on to talk about why polyphenols are so incredibly important. I guess we're going on six years ago now. He used that example. And that it's okay to think outside of the box which is essentially what he was saying to challenge dogma is to go outside of this box that we have built around ourselves. If it weren't for someone venturing outside, we never would have made innovation. Ken Brown 52:08 And the beauty of the technology that has allowed you to have this stage where 600,000 people sign up for summon at one time, also allows us to share globally information in a way that we couldn't before. So when I sit there and meet with some of my colleagues, and they're like, oh, there's no science on that. I'm like, Oh, really, let me pull up my Mendeley account. Really, here's 8000 articles on what we're talking about. Why don't you start reading that and when in my world traditional medicine world especially in Texas, I think that different states a little more progressive, like California has always been a little more open to the functional medicine side but Texas, not so much coming around. But when the drug rep to my left over here when doctors say there's no science on that what they're saying is somebody is not brought me lunch with a detailed piece explaining what I'm supposed to say. That's really what I'm saying. And we're all really busy. And that is what it is. But it just happens to be just like you. You go, um, you know, I'm tenacious, but I'm armed with science, therefore, I can walk into this battlefield and hold down, even if they even if they call me crazy.Dr. Tom O'Brian 53:17 Yeah, cuz that's exactly right. Last week I did an interview for a neuro psychiatric psychiatry group. And the doctor who coordinated the interview, she said, you know, Dr. Brian, I heard you speak three years ago at our conference, and you yelled at us on stage. No one's ever yelled,at us on stage before your neuropsychiatrist they're the cream of the crop in their own mind. You know, they're legends in their own mind. Right. AndKen Brown 53:48 voices in their heads.Dr. Tom O'Brian 53:50 Yes, right. Good, catch. Good, good. But what I said to them if you aren't spending one hour a week, reading the current literature Cutting Edge literature in your field of expertise, shame on you. You're outdated, one hour a week. And nobody's got time for any of this. But if you don't do that you're outdated within a year. Yeah. And, and she thanked me. She said, You know, I took what you said to heart because it made sense. I didn't like how you said it, but I liked what you said. And the result is I've completely changed my practice in three years. Thank you so much. I really want to acknowledge you here on the microphone in front of all of my colleagues, that was such an excellent recommendation to us and i and i say that to everyone. Whether you're a general public, or a health care practitioner, one hour a week. That's what it takes to have 10 that's tenacity and then prepare your mind to challenge the way you think so that you can read the map of what's happened to your body so far,Eric Rieger 54:58 don't you one of the reasons why really enjoy doing our show is that I'm a better doctor because of it because I prepare for different things because I have to research a lot of stuff. When we talk about topics. You're the exact same way you have gone. You started with the gluten and the you went to the brain. You're looking at this now you've got different you've got the whole erm. Dr. Tom O'Brian 55:20 bottle immunityKen Brown 55:21 Yeah, but what's the name of the of the program again?Eric Rieger 55:25 betrayal, Ken Brown 55:26 betrayal, betrayal. Yeah, I was I was trying to think of that. So when you do that you automatically your passion will have you read this. So I'm going to ask for your help. Maybe it's not you. Maybe it's some other people that you meet, but we're running into something. So when I say my Mandalay account, I have a graduate student that I work with and she finds everything If you need anything, let me know just email me She will find it and get the articles and so we can sit there and look at some of this but I'm seeing something and I think that you're probably seeing it also and it is This weird it becomes down to a nerve, dysautonomia motility type situation that can be the underlying cause of a lot of gastrointestinal issues which then lead to neuro inflammation. And now we're getting to the vagus nerve and we're talking about this I've got some really sick people that come to me and they're they've all been to the Mayo Clinic they've all been to the Cleveland Clinic and they all have been told that it's functional this and that, that it's in their head and they all say you should start taking Prozac but these are really intelligent people really type a people that had very successful their attorneys or accountants and this and that. I'm seeing a trend here that the chronic disease is affecting the nerves that is it acetylcholine Do we need to start working on the you know, the, the vagus nerve, I don't know. But I it just feels like more and more people are showing up there. They're really trying what's your what's your take on that? Because if we can figure this out. That's it.Dr. Tom O'Brian 57:00 This is this is a PhD discussion that we're now getting into that is at the core of the answer to your question. Arguably the number one journal in the English language for children's health is the journal Pediatrics put out by the American Academy of Pediatrics. They published a policy statement, which means it's not an author, you know, if I were to get an article published in pediatrics as an author, I've scored top tier difficult journal to get into I've really scored but this is a policy statement. That means it came from the board of the Academy of the American Academy of Pediatrics, and they said the toxic substance Control Act failed miserably to protect our children and princes and adults. And it is The governing legislation at the federal level for all chemicals introduced into our environment. This was passed in 1976. It's still the regulating guidelines for all chemicals introduced into our environment. It the the guidelines are so cumbersome, that in 40 years, they've only regulated five chemicals or classes of chemicals in 40 years. Because the lobbyists were so successful in paying off the senators and the representatives to pass this legislation that has no teeth. The legislation says you have to show that the amount of whatever chemical a person is exposed to is toxic to them. When you pump gas and fill your tank with gas, can you sometimes smell the gas? Sure, of course. you're smelling benzene,Ken Brown 59:09 right? Oh, yes.Dr. Tom O'Brian 59:10 Benzene going up your olfactory nerves right into the brain triggering inflammation killing off brain cells right now. Right? It's killing brain cells. But there's no evidence that the amount of benzene it's inhaled while pumping gas is toxic to humans. There's no evidence you can't. There's no evidence that it causes a problem. But give me 30 years of smelling benzene once a week and how many millions of cells you've killed off. I'm warming up now. 2017. papers published that came out of Chicago 346 pregnant women and the eighth month of pregnancy They did urine analysis they measured Phthalates five Phthalates Phthalates are chemicals used to mold plastic. Most of us have heard of Bisphenol A or BPA Corona is one of the chemicals. They measured five chemicals. There are hundreds of chemicals but they just measured five. they categorize the results into quartiles, the lowest, the next, the third and the highest quartile. They then follow the offspring of those pregnancies for seven years. When the kids turned seven years old, they did Wechsler IQ tests on the official IQ test. There's not much in medicine, that's all or every This was every every child whose mother was in the highest quartile of Phthalates eats and urine and pregnancy compared to the children in the lowest quartile of Phthalates and urine and pregnancy. Every child in the highest score tile, their IQ was seven points lower than the kids in The lowest quartile of Phthalates seven points. That doesn't mean anything to anyone until you understand one point difference is noticeable. A seven point difference is a difference between a child working really hard getting straight A's, and a child working really hard, getting straight C's, right this kid in hell because his brain never developed properly. And then just go to Google and type in Phthalates and neurogenesis, nerve growth. Here come all the studies, how balades inhibit nerve growth. And you see this and you wonder why Autism is going up and attention deficit is going up. You see this and then you go back to the pediatrics article and you read that is 247 pounds of chemicals manufactured or imported into the US United States every day for every person in America 247 pounds, that's 27 trillion pounds a year, take the population of the US multiplied by 247 times 365 days, it's 27 trillion pounds.Every newborn child in America has at least 200 chemicals in their bloodstream at birth that aren't supposed to be there. Many of them are neurotoxins, brain time. You wonder why we're seeing this increase in disease. We all are walking sewage dumps, excuse me, but we are we all are because it's in the air. You if you sit in a room and you can see the sunlight coming through the window, sometimes the right time of day the angle and you see little dust in the air. That's what you're breathing. That dust is the family lychee From the plastic lines in the windows, they leach out family chemicals into the air for years. It's the scotch guard on the sofa, leaching out those chemicals into the air for years. It's the formaldehyde in the kitchen cabinets. If they're not solid wood, they're pressboard. They're soaked in formaldehyde, and the bathroom cabinets leaching out into the air for years. And we were exposed to all of this, all of that and we're walking sewage dumps. You wonder why degenerative diseases are going, why Alzheimer's and the number one type of Alzheimer's is inhalational Alzheimer's, it's what's your breathing. This is so overwhelming for people. When you get when you look at this map. When you see what's happening. It is so overwhelming. That's why you have to operate from the platform of one hour a week. Yes, because and so one week When you learn that the leftover chicken from dinner, you put it in a plastic storage container in the refrigerator. The next day the chickens got phalates in it from the plastic. When you learn that one week, you take that hour you go into my book and there's the three URLs to order glass storage containers, and you go to miles, kimball.com and Amazon, whatever the third was, Oh, I like those. And yours three round ones in two square ones and one for the eyes. You pay with your credit card, you hit send, it took an hour, you're done for the week. Like that. Never again, will you poison your family with minute amounts of foul aids from leftover food in a plastic storage container. Now, there's no evidence that the amount of families that leach out of plastic storage containers is toxic to humans. That's how they get away with that crap it is. That's how they've gotten away with it. And it's the it's the The indoor and just read the science indoor air pollution is much worse than outdoor air pollution in most areas of the country. Because we don't think about our homes we don't think about the formaldehyde, the benzene, trichloroethylene that we're inhaling, then you go to my book and there's the study with the graph that the study from NASA that shows to six inch house plants, and there's the list of all the house plants that do it to six inch house plants and a 10 by 10 room absorbs up to 70% of the toxic chemicals in the air.Ken Brown 1:05:37 warmer times. This is the front so now you're scaring the snot out of me, but now you're giving me a solution. So you're saying when your book can gotDr. Tom O'Brian 1:05:43 a Kleenex, hand him a Kleenex to get the snot and to six inch houseplants, and there's about 12 or 14 different types of houseplans six inch houseplants absorbable To 70% of the toxins in the air in a 10 by 10 room, they're absorbed through the leaves, they go down into the roots, the microbiome of the soil breaks that stuff down. They produce oxygen and put oxygen into the air to 10 by 10 to six inch houseplants for a 10. By 10 roomEric Rieger 1:06:17 solution.Ken Brown 1:06:18 Yeah, it's a solution I'm all about so and so your book is not just teaching people what to worry about, but you're like, this is the solution. So the one hour a week is I'm going to give you one hour a week solution. And if you continually do that, by the end, you're going to be a healthier person.Dr. Tom O'Brian 1:06:35 You know, everybody wants solutions. Nobody wants to hear about the problem. But there's no way you will have the tenacity to do this. And at a pace that you can do it and not be overwhelmed. That's why it's one hour a week understanding. You are going to be overwhelmed, but you're going to do bite sized pieces pieces of this. And in six months. You've got it. You've changed your life. Your husband Using the Tupperware containers to store nails in the garage, right? I mean, you've got all the the dishwasher, you'd never run the dishwasher during the day. Because the toxic chemicals that come out of the dishwashing detergent, when they get heated up to 160 - 170 degrees, they leach out of dishwashers are not airtight. They're watertight, they're not airtight, and those chemicals are in the air, you're sucking those fumes. You only run the dishwasher at night when everybody's sleeping. And you've got to learn all these little things because the paradigm that we've accepted the prevailing dogma that we've accepted about the way to live life and about our homes is killing us. It's slowly killing us. This is why your patients are coming in with more confusing results is because they're loaded full of all of these toxic chemicals. How many of us have been watching the chem trails? For years to say, Oh, that's really something you know that that's too bad. Yeah, I wonder what that stuff is. And we've never done anything about it. We're sucking the fumes of all those heavy metals that were being spewed into the air.Eric Rieger 1:08:12 Yeah, well, I do want to add something here. I know that we've been it didn't seem like until just looked. But we've been talking for a good while. And I need to also give you some praise since you were the first to utilize the digital internet to reach so many people. You also have one of the most kick ass URLs I've ever seen. Yeah, so what is it? We do? SoKen Brown 1:08:34 we haven't ever joked about this? I was like, how in the heck did that guy get that URL?Dr. Tom O'Brian 1:08:39 1996Eric Rieger 1:08:42 the URL to link up with this very Dr. Tom O'Brien is the doctor.com and I want to say that one more time the doctor.com but you have the Dr. Yeah, I'm sorry. Yeah, you're the Dr. calm. So Dr. Bri ER doctor abbreviated v dr.com. dr.com will connect you with Dr. Tom O'Brien. But you also also have two specific programs for our listeners. One is to do that with a / betrayal to get on to the train of exactly the training that you're talking about and the other one, and I'll put, I'll put this in show notes, everyone, but the other one is thedoctor.com/kickstart. And if you want to do a quick rundown on exactly what kickstart is, that way, everyone in our universe can hop over and learn a little bit more from that from that with from you. Just tell us a little about thedoctor.com/kickstart.Dr. Tom O'Brian 1:09:36 You bet that Thank you. The kickstart is a number of handouts for you. They're going to talk about how to detox your house, how to reduce electromagnetic pollution in your house. What are the house plants that will suck up toxins? There's there's a handout for the kitchen there's a handout for the bathroom. There's a handout for the bedroom, all a number of different handouts so that you've got Steps to implement right away and you take them at your own pace, you'll get the plastic storage containers out of there, order glass storage containers, things like that.Ken Brown 1:10:10 Dr. Tom, I want to interrupt you real quick because you've hit a nerve with me here this is I just don't have the I'm always I spent a lot more than just an hour a week. But I spent an hours a week looking at the stuff that I'm interested in. And I have a blind eye to what you're talking about. And what you just said is I'm going to give you solutions. You can put a handout up, you're just going to go do this, this and this, because I believe you and I, I don't want to read a whole book about why I should get rid of my plastic just Just tell me how to how to fix it. That's what I like. kickstart seems like a really cool program for that.Dr. Tom O'Brian 1:10:46 Oh, thank you very much. And if you were my patient, I'd be all over you. That you can't do that because it's wanting solutions that has gotten us into trouble. Oh, gotta understand. All of you. The map of what happensKen Brown 1:11:01 this where you start yelling at me like you did on stage.Dr. Tom O'Brian 1:11:06 Because if you don't understand that mold can be a huge problem for Mrs. patient. When you go on vacation for a week or two, when you come home, you have to open the windows to air the house out. Oh, yeah, you got mold. You have to have the house remediated, you have to have a professional come Well, I don't have a problem. When I'm here. I don't feel anything. It doesn't matter if you feel it or not. If you're inhaling it, it's going up to your brain. And it's the number one trigger for the development of Alzheimer's is in halation, Alzheimer's, it's what you're breathing. So if your brain ain't cooking the way it should be, it's cooking in the wrong direction, you're too much on fire. You have to identify where it's coming from so you can get all the house plants you want. But if you still got mold in your bathroom, well it's not too bad on the tiles there. You know, it's just on the grout in between the tile that's not too bad. We'll Put that on your tombstone. It wasn't too bad. You know, it's critically important that we change our paradigm so that we understand what our individual map is, what has gotten us to where we are, because that map is going to change, you're going to get better because you implement the things in the handouts. That's great, you're going to get better. But a year from now, two years from no
La auto experimentación es una práctica muy antigua en la que el experimentador se convierte en el sujeto de investigación. Muchas veces esas investigaciones resultan peligrosas y potencialmente letales para el mismo experimentador, casos conocidos en la historia de la ciencia que no han persuadido a quienes, con la urgencia de una idea en su cabeza, han decidido poner sus propios cuerpos al servicio de su curiosidad. Historias de auto experimentación serán las que revisaremos en este capítulo de La Ciencia Pop *** La Ciencia Pop cuenta con el auspicio de CGESTA, gerenciamiento e inspección técnica de alta eficiencia para proyectos de construcción, con más de 2 millones de metros cuadrados de experiencia en los ámbitos de retail, industrial, oficinas, salud, educación e inmobiliario. Para más información, visite la página www.cgesta.cl *** Support the show (https://www.patreon.com/LaCienciaPop)
Is a Young Earth Possible? argues for a youthful world from history and science. In the 1970’s, Australian doctors Robin Warren and Barry Marshall proposed that the bacteria Helicobacter pylori caused ulcers. It took two decades before their conclusion was justly recognized by the scientific establishment. Has Big Science misdated the earth? Is a Young Earth Possible? relates to a number of key issues in the public square such as climate change, homeschooling, government funding of science, bullying, depression, fake news, net censorship, and free speech. To learn more about Prof. Jay Hall and his work, visit www.YoungEarthScienceBook.com To get your copy of Is a Young Earth Possible?, please visit our Amazon.com affiliate link.
Hour Invite Podcast Episode 1 | featuring Dr. Bill Kernan | A Bias For Yes!
Dr. Barry James Marshall is an Australian physician, Nobel Prize Laureate in Physiology or Medicine, and Professor of Clinical Microbiology at the University of Western Australia. Dr. Marshall won the Nobel prize in 2005 for the discovery of the bacterium Helicobacter pylori and its role in gastritis and peptic ulcer disease. _____________________________________________ hourinvite@gmail.com http://www.hourinvite.com http://www.facebook.com/hourpodcast http://www.instagram.com/hourinvite https://www.linkedin.com/company/hourinvite
Dr. Barry Marshall was a middle-of-the-pack doctor at a middle-of-the-pack hospital in Australia. Yet, in the early 1980s, this average doctor's idea would completely overturn conventional medical thinking and change the world.
Is a Young Earth Possible? argues for a youthful world from history and science. In the 1970’s, Australian doctors Robin Warren and Barry Marshall proposed that the bacteria Helicobacter pylori caused ulcers. It took two decades before their conclusion was justly recognized by the scientific establishment. Has Big Science misdated the earth? Is a Young Earth Possible? relates to a number of key issues in the public square such as climate change, homeschooling, government funding of science, bullying, depression, fake news, net censorship, and free speech.To learn more about Prof. Jay Hall and his work, visit www.YoungEarthScienceBook.comTo get your copy of Is a Young Earth Possible?, please visit our Amazon.com affiliate link.To learn more about Provocative Enlightenment Radio, go to http://www.provocativeenlightenment.com
The gang are back again! This time, 2005 Nobel Prize winner and YoYo State Champion Barry James Marshall is the subject of their discussion. See acast.com/privacy for privacy and opt-out information.
At være så passioneret, så klar til at modbevise verden, at du er villig til at tage din forskning om dødelige patogener og giftige kemikalier, og teste dem på dig selv! Det er typen af mennesker, vi skal tale om i dag. Mennesker der står på grænsen mellem gal og genial, og som kun falder til den ene eller anden side som produkt af deres konklusioner.Hør os fortælle om nobelprismodtageren Barry Marshall, der drak sin kultur af den mavesårsfremkaldende H. pylori, om kokain-"mis"brugeren August Bier, der opdagede og anvendte kokain som bedøvelsesmiddel og opkast-entusiasten Stubbins Ffirth, der var rigtig heldig i at han havde ret i sin hypotese om gul feber. Hold kæft, han kunne have været død mange gange, mand.Tak til Nikolaj for at være vores praktikant.Der er fri fragt på bit.ly/spækshop! Fra onsdag d. 23. til fredag d. 25. Du skal bare bestille og købe. Vi har T-shirts, kaffekopper og tasker! Og meget mere! Der er også en hønsetrøje!Fortæl om Spækbrættet! Vi er både på iTunes og Spotify og alle andre steder! Bit.ly/spækitunes bit.ly/spækspotSend os water hilarious science eller stil et spørgsmål på facebook, Instagram eller spaekbraettet@gmail.comHusk at være dumme
On this episode the membership open up with "In The News" and discuss the first crime committed in space by Astronaut Anne Mcclain, Barry Marshall's effort to stop the Greater Grand crossing rapist plus we discuss The Cash Money reunion (of sorts) with Juvenile, Birdman and Lil Wayne, Moving into the topic of the night, we discuss the different terms for loose women over the era's "Bust Downs {Bussa}, Runner, Stragg, Thot" and our personal preferences. We wrap it up with "4 Useless Facts". Epikness In the news: Anne Mcclain Story:https://www.nytimes.com/2019/08/23/us...Greater Grand Crossing rapist Storyhttps://abc7chicago.com/south-side-re...Birdman, Juvenile, Lil Wayne "Ride Dat" https://www.youtube.com/watch?v=C8nNT...Listen to episodes of the Supreme Podcast on Only4TheReal Radio Apple Podcast: https://apple.co/2Rcv8zQiHeartRadio: https://ihr.fm/2RkO7EcSpotify: https://spoti.fi/2AKe6i8Spreaker: https://bit.ly/2QJY4tK
This week's episode comes with a warning: don't attempt this at home. While self-experimentation has led to many a scientific breakthrough, we're definitely not advocating it. But it happened to work out for the best for Barry Marshall and Robin Warren, even earning them a Nobel prize. That’s right folks, today we’re talking about none other than Helicobacter pylori, the curvy little bacterium identified only a few decades ago to be a causative agent of peptic ulcer disease, a major risk factor in the development of gastric cancer, and a fierce warrior who can survive the harshest of environments: your stomach.
Dan has a Nobel Prize Winner on this week's show! Dr Barry Marshall won the award in 2005 for discovering the bacteria that causes stomach ulcers! Dan chats to him about this discovery and his new book 'How To Win A Nobel Prize'. Plus, Dan continues to explore the most dangerous parts of the world, and the science from the past week!
Episode #109 - We are joined by Joy Sybesma, Chief People & Culture Officer at Kargo, Barry Marshall, Co-Founder and Principle Consultant & Nancy Gill, Co-Founder and Principle Consultant at P5 Collabrorative Consulting to discuss developing the next generation of chief People Officers and much more.www.hrdleaders.com/podcastRecommended ResourcesThe Artist's Way: A Course in Discovering and Recovering Your Creative Self - Julia CameronScaling Up: How a Few Companies Make It...and Why the Rest Don't - Verne HarnishThe Culture Code: The Secrets of Highly Successful Groups - Daniel CoyleRadical Candor: How to Get What You Want by Saying What You Mean - Kim ScottFierce Conversations: Achieving success in work and in life, one conversation at a time - Susan ScottNew York Times, Harvard Business Review, FT.com, McKinsey QuarterlyLinkedIn, SlackThank you to our friends at Safeguard Global for supporting the showExpanding and managing workforces in new international locations creates a time and resource drain for already stretched HR leaders. Safeguard Global can hire employees on your behalf - while providing full management of local tax, labour laws and payment of your workers and contractors.Visit safeguardglobal.com/hrleaders for your complimentary guide to strategic considerations for HR in the age of global workforce expansion. Start your global growth engine today.”
“Discovery requires serendipity but serendipity is not a chance event alone. It is a process in which a chance of event is seized upon by a creative person who chooses to pay attention to the event, unravel its mystery and find a proper application for it.” In this episode of Made You Think, Neil and Nat discuss Happy Accidents by Morton A Meyers. In this book we look at the serendipity of so many scientific discoveries and the author suggests how we can foster these chance happenings to make giant leaps in research and discovery. “Penetrating intelligence, keen perception, and sound judgment — is essential to serendipity. The men and women who seized on lucky accidents that happened to them were anything but mindless. In fact, their minds typically had special qualities that enabled them to break out of established paradigms.” We cover a wide range of topics, including: Penicillin, Petri Dishes and Moldy Mary The impact of freedom on research Tangents on Private Schools, Social Media & Conspiracy Theories Modern Diets, Drugs and Toxins turned into cures Self experimentation, Ostracism and changing Medical opinions A possible special kayaking retreat for supporters And much more. Please enjoy, and be sure to grab a copy of Happy Accidents by Morton A Meyers! You can also listen on Google Play Music, SoundCloud, YouTube, or in any other podcasting app by searching “Made You Think.” If you enjoyed this episode, be sure to check out our episodes on Skin in the Game by Nassim Taleb where he shares other stories of scientists trying treatments firsthand, and Merchants of Doubt by Naomi Oreskes and Erik Cornway for more on controversial science, academia and Pharma companies. Be sure to join our mailing list to find out about what books are coming up, giveaways we're running, special events, and more. Links from the Episode Mentioned in the show Bottom Up Methodology [01:31] Scientific Method [1:48] Penicillin [05:27] LSD Discovery [05:48] Contact High [06:01] Dogmatic [06:19] Petri dishes [08:01] Lifehacker [08:47] The Structure of Scientific Revolutions by Thomas S. Kuhn [9:31] Narrative Fallacy [16:17] Fleming Nobel Prize Speech [17:38] Peoria, Illinois [26:03] Corn Steep Liquor [26:09] Merck [26:48] Squibb [26:48] Pfizer [26:48] World War I [27:42] Aquatic Apes [29:04] Sippy Diet [30:27] Tetracycline Antibiotic [31:47] Acid Inhibitors [34:14] Statins [34:36] Carbohydrates [36:16] LDL [36:20] LDL receptors [36:33] Viagra [38:26] Asbestos [39:46] Facebook Groups [42:14] Discord Groups [42:15] Carnivore Diet [42:49] Shake Shack [44:04] M&M’s [44:07] Purina Dog Food [46:08] Stats of College Debt – Tweet [46:32] CMU [52:40] Choate School [53:45] Sidwell Friends [54:23] Boarding Schools [54:34] Alkylating Agents [57:15] Geneva Convention [58:08] Patreon [01:02:08] Google Trends on episode 35 [1:02:00] Epidemics [01:02:27] SARS [01:02:54] Influenza [01:02:56] Syphilis [01:03:22] Fish Aquarium Antibiotics [01:04:53] FDA [01:07:51] Nazi Testing [01:08:04] Japanese testing on Chinese prisoners [01:08:08] Tuskegee Study of Untreated Syphilis in the Negro Male [01:08:19] Eugenics [01:10:18] Darwinism [01:10:31] (related podcast) Russian Gulag [01:11:38] Thalidomide [01:11:52] Diethyl Glycol [01:12:59] Food, Drug and Cosmetic Act [01:13:10] Accutane [01:15:06] Doxycycline [01:16:26] Microbiome [01:16:52] Eczema [01:17:43] Steroids [01:17:36] Spartan Race [01:20:09] Nat’s Instagram [01:20:15] Blockchain [01:21:06] X-Rays [01:22:29] Morphine [01:23:51] American Urological Association [01:24:48] CVS patient statistics for Viagra [01:29:42] Netflix [01:31:18] Spleen [01:32:47] Confirmation bias [01:34:43] Ego death [01:39:38] Dissociative experience [01:39:40] Magic mushrooms [01:40:02] LSD Therapeutic Research Study [01:41:03] NASA [01:46:22] Direct to Consumer Drug Advertising [01:46:29] ADD [01:47:41] Premenstrual Dysphoric Disorder [01:47:58] Prozac / Seraphim [01:48:09] Paxil [01:48:18] Female Sexual Dysfunction [01:48:24] Lipitor [01:48:57] Zoloft [01:49:16] UBI [01:53:07] Ethereum [01:59:48] Books mentioned Happy Accidents by Morton A Meyers Beginning of Infinity by David Deutsch [00:42] (book episode) The War on Normal People by Andrew Yang [00:51] (book episode) Antifragile by Nassim Taleb [07:02] (Nat’s notes) (book episode) The Structure of Scientific Revolutions by Thomas S. Kuhn [9:31] Boron Letters by Gary C. Halbert [14:44] Skin in the Game by Nassim Taleb [30:00] (Nat’s notes) (book episode) Merchants of Doubt by Naomi Oreskes and Erik M. Conway [01:02:02]] (Nat’s notes) (book episode) Merchants of Doubt by Naomi Oreskes and Erik M. Conway [01:02:02] (Nat’s notes) (book episode) Homo Deus by Yuval Harari [01:02:36] (Nat’s notes) (book episode) Words that Work by Frank Luntz [01:28:24] LSD My Problem Child by Albert Hofmann [01:40:51] Brave New World by Aldous Huxley [01:48:46] People mentioned Morton A Meyers David Deutsch [00:42] (Beginning of Infinity episode) Andrew Yang [00:51] (The War on Normal People episode) Winston Churchill [05:04] Alexander Fleming [05:29] Nassim Taleb [07:02] (Antifragile episode) (Skin in the Game episode) Thomas Kuhn [09:21] Peter Thiel [10:12] Gary C. Halbert [14:44] Charles Darwin [18:39] (Daniel Dennett’s book) Ernst B Chain [22:31] Moldy Mary [25:56] Barry Marshall [31:07] Robert Koch [32:10] Bill Clinton [01:00:32] George W Bush [01:01:18] Erik M. Conway [01:02:02] Yuval Harari [01:02:45] (Homo Deus episode) (Sapiens part I and part II) FDR [01:13:08] Claude Bernard [01:22:24] Frank Luntz [01:28:24] John William Gofman [1:31:35] President Eisenhower [01:34:48] Timothy Leary [01:40:28] Albert Hofmann [01:40:51] Steve Jobs [01:41:00] Louis Pasteur [01:45:32] Aldous Huxley [01:48:46] Show Topics 00:26 – The book is fun to read, light, enjoyable, easy going. An exploration of scientific discovery and progress and how consistently it is influenced and driven by the role of Serendipity. A case opposite or complementary to the Scientific Method. Serendipity defined as a combination of accidents and sagacity. 05:05 – Not all discoveries are immediately realized or understood. Winston Churchill – “Men occasionally stumble over the truth, but most of them pick themselves up and hurry off as if nothing had happened”. Penicillin and LSD examples. The dangers of being dogmatic without leaving room for the unexpected. 06:53 – Central theme of the book–How do you foster that serendipitous mindset? Nassim Taleb says that serendipity comes from chance encounters, like a cocktail party. The potential gain from a chance encounter is worth the effort of stepping outside your comfort zone. 07:42 – Trying to harness serendipity for your own benefit. Serendipity through disorder and randomness. Investigating how scientists can foster serendipity in their lab work and how academia and education and research grants, peer review could change because of that. 09:41 – Normal vs revolutionary science, Meyers is dismissive of puzzle solving. Normal science is making incremental improvements on existing knowledge, whereas serendipity fosters revolutionary discoveries as they come from a change in the ordinary methods. 10:51 – Two stages to serendipity. You need something unusual to happen and you have to recognize it to take advantage of it too. 11:21 – Innovation departments rarely come up with paradigm-shifting ideas and products. Need a certain mindset to make the most of these opportunities. Reason, intuition and imagination. Too much experience in a field can cloud your judgement on new ideas. 13:51 – The book is primarily about serendipity in medicine and science but it can be applied to most fields. Breaking out of the norm and finding inspiration for innovation in other industries. Looking at magazines to apply to blog copywriting. 15:33 – "Analogical thinking has certainly been a cornerstone of science." Another theme in the book is looking for one thing but ending up on a totally different path. All of the people making discoveries seemed to have a level of independence in their research to follow a new path when it interests them. The narrative fallacy involved in serendipitous scientific discovery or startups growth. 17:40 – Alexander Fleming and discovery of Penicillin as anti-bacterial. Fleming said that if he was working on a research team at the time it would have been ignored as it wasn’t what he was working on. Being free allows you to pursue these anomalies. 19:04 – Darwin and the finches in the Galapagos. Being told to go and study something brings different results than if you’re free to follow your own curiosity. The constraints of research impose harmful limits on discoveries. 19:54 – Structure of the book is Introduction of the premise, 30+ chapters of examples and the conclusion. Myers suggests at the end of the book that the structure for scientific research and funding is counter to the ability for these serendipitous events to happen. 20:50 – More on Fleming and Penicillin. Odds of it happening were astronomically low. He was away for two weeks and on returning and viewing his petri dishes on his desk discovered an anti-bacterial zone around the mold. It wasn’t until 7 years later that another researcher realized what he had found. 23:09 – For Fleming it took a number of environmental factors that allowed Penicillin to be discovered at all: heat, location, time. Penicillin wasn’t originally pitched as a drug, originally suggested as a way to isolate bacterial colonies. Then there was the huge scale up and production process of the drug. Peoria (IL), the role of corn syrup, and the mold discovered by chance. 29:00 – Bonus Material Discussion, Aquatic Apes, Patreon, future episode ideas. 29:52 – Causes of ulcers, used to be thought of as stress and spicy food. Discovery that it is caused by bacteria in 1981. Marshall ran an experiment on himself to take the bacteria, give himself ulcers and cure himself with antibiotics. Pharmaceutical industry had a strong incentive to not prove this as the cause, current drugs of acid inhibitors were reaching sales of $6 Billion dollars in 1992. 35:04 – Pharma companies lobbying to decrease acceptable cholesterol ranges to induce more people into treatments. Changing opinions of statins within last 10 years. Effects of low cholesterol on longevity, links to all-cause mortality. Reducing cholesterol and precursors to creating testosterone in diet has lead to a reduction in testosterone and erectile dysfunction requiring a need for Viagra. 39:59 – What are we currently doing in society now that we will look back on and question in the future? Possible future problems associated with over consumption of social media. Mental and physical health complaints are unknown. 41:53 – Pull away in society from open sharing, moving towards private communities. Effectiveness of diets, feeling good vs having long term health benefits. Benefits of adopting a new diet may be equal to reducing other harmful choices – like stopping drinking for a month. The changing conventions of meal-times, quality of dog food, college debt. 47:12 – Tangent. Education and the need to change the K through 12 program instead of starting with College reform. The benefits of private vs public school. Mixing with different socioeconomic backgrounds, expense of private school. Both build very different sets of social and academic skills. Bay Area dystopia, where citizens pay lots in taxes that go into public schools, but parents end choosing private ones. 55:53 – Chemical weapons, World Wars and the changing use of toxins into cures. Bombing a ship leading to the first chemo treatments for cancer. North Korea and the development of nuclear tech (more info in the Bonus material). Google health trends being able to predict health outbreaks based on search volume. Sex hormones and noticing the change of tumors in animals after castration. 01:07:55 – Consequences of controversial testing on wartime prisoners that have given us useful data. Study of African-American men with syphilis, they were told they were having free medical treatment but they were mislead and were being studied for the untreated effects of syphilis over 40 years. Possibilities of current testing on prisoners or other conspiracies. 01:11:52 – History of Thalidomide being marketed as a sedative and pain management. Widely distributed before it was realized it had the side effect of severely inhibiting fetal development. U.S avoided this because the FDA already setup due to a drug being administered alongside Diethyl Glycol which was toxic, killing over 100 children. Testing required before products could be marketed. Thalidomide now used as an anti-cancer drug as it inhibits new blood vessel growth. 01:15:05 – Acne treatments and the imbalanced side-effects on fertility. Use of cleanser on the face strips natural oils. Use of antibiotics for acne which causes destruction of the microbiome. Latex gloves that may transmit more bacteria than your hands. Effects of steroids and keto on curing eczema. Nat not using shampoo even after a Spartan race. Body naturally cleansing. 01:21:06 – Tangents, aquatic apes, blockchain, negative reviews. 01:21:59 – Heart chapter and testing of catheterization. Self-experimentation and the need to prove theories. Ostracism and dangerous procedures. 01:24:44 – Viagra, originally for treating angina, it was found that this medication increased blood flow and became a cure for impotence – renamed to erectile dysfunction. Self-experimentation on erectile dysfunction. "The annual scientific meeting of the American Urologic Association is usually a pretty staid Affair but one meeting has entered the annals of folklore in the early 1980s. During the course of his lecture on the effectiveness of injecting substances directly into the penis to increase blood flow one urologist announced that he had performed such injections on himself only an hour earlier. Stepping from behind the lectern and he dropped his trousers and proudly demonstrated to the audience his own erect manhood. Urologists who attended this meeting still shake their heads at the memory." 01:28:00 – The power of names and the words used, like pro-life and pro-choice. How you phrase something changes the impact. Pharmaceuticals changing the names of conditions to promote sales of new drugs. Sales of Viagra were $780 Million in the first 9 months of 1998. 01:30:02 – 1% of women take Viagra to increase arousal and sensation and orgasm strength. Netflix’s biggest competitor is sleep, Viagra’s biggest competitor is death. 01:31:48 – Cholesterol testing on rabbits. Cholesterol data seems outdated with the book being 11 years old. Comparison of Chinese soldiers and lifestyle and diet. Lack of nutrition education in Doctors, mostly educated by pharmaceutical companies. People seem to want to take a pill rather than change their lifestyle or diet and doctors have lack of trust in the patient that they will try to improve their own situation. 01:38:07 – Psychiatric stuff. Hoffman discovering LSD by accidentally pouring it over his skin. LSD microdosing experiences. 01:42:40 – Tangents on kayaking, LSD microdosing and the Made You Think – Patreon $1000 Tier. 01:43:06 – Conclusion. Modern sciences are antithetical to the process of serendipity and how our institutions penalize our ability to take advantage of it. Government contracts and grants impose constraints. If you're getting money to research a specific topic you will be disincentivized from exploring things that deviates. If you're a free agent, then you can run down those rabbit holes. 01:44:31 – Peer reviews. Most businesses are judged by their customers but academia is judged solely by their peers. Ostracism as a consequence of investigating fringe theories. Direct to consumer advertising for drugs. Diseases and disorders that seems to be created and renamed just to increase drug sales. Long terms effects of drugs. 01:52:19 – On Patreon you get all kinds of goodies. Bonus materials, detailed notes for each episode and book highlights. You get a space to discuss the show with both of us. You can also join for our monthly live Hangouts. If you join the $1000 a month tier you can join us for a major excursion – Made You Trip! 01:54:57 – Patreon is a great way to support the show and let us keep doing this ad free. So we don't have to break up the episode with ads and we keep rolling with the tangents. 01:55:48 – Leave a review on iTunes that is super helpful for us because we show up as a recommended podcast and also is a great way for us to book guests. Other ways to support the show, you can go MadeYouThinkPodcast.com/support and tell your friends. 01:57:58 – If you want to talk to us, you can talk to us on Twitter anytime. I'm @TheRealNeilS and I am @NatEliason. If you're shopping on Amazon click through on our link. We super appreciate that. All right, we will see everyone next week. See you guys next time. If you enjoyed this episode, don’t forget to subscribe at https://madeyouthinkpodcast.com
A further look at ten more scientists who experimented on themselves for the benefit of mankind.
Professor Barry Marshall returns to talk about his continued research into the bacterium Helicobacter pylori, including failed attempts to infect piglets in 1984 leading him to use himself as the 'animal model'.
Dr Sean Stevens sits down with Clinical Professor of Microbiology at University of Western Australia and Nobel Prize recipient Professor Barry Marshall. In this episode, Barry talks about life growing up, his pathway to medicine and the start of his collaborative relationship with Dr Robin Warren.
This Medical News podcast features an interview with Barry Marshall, MD, who codiscovered the stomach bug H pylori in 1982.
This Medical News podcast features an interview with Barry Marshall, MD, who codiscovered the stomach bug H pylori in 1982.
Evolution Radio Show - Alles was du über Keto, Low Carb und Paleo wissen musst
Bitte beachten Sie auch immer den aktuellen "Haftungsausschluss (Disclaimer) und allgemeiner Hinweis zu medizinischen Themen" auf https://paleolowcarb.de/haftungsausschluss/ #geNUSS[explosion] von [næhr:sinn] - das low carb knusper nuss müsli [næhr:sinn] geNUSS[explosion] ist ein hochwertiges low-carb* Müsli und besteht zu 100% aus natürlichen Zutaten. Es ist gut als Frühstück und Snack und hat nur 13,7g verwertbaren Kohlenhydraten auf 100g. Es ist getreidefrei und sojafrei. Perfekt für den Start in den Tag. Wir verarbeiten nur hochwertigste, nährstoffreiche Zutaten, die dich länger satt machen und nachhaltig mit Energie versorgen. Wir nutzen ballaststoffreiche Kokosnuss, Erdmandel und heimische Nüsse. Mehr darüber erfährst du auf lowcarbmüsli.at oder auf Amazon.de In Folge #108 Das Video der aktuellen Folge direkt auf Youtube öffnen Und nicht vergessen: Wenn du uns auf YouTube siehst, und wenn du es noch nicht getan hast, dann abonniere unseren Kanal „Evolution Radio Show“ Wenn du das Podcast hörst, dann findest du die Links für Apple iTunes und Android hier auf unserer Homepage Kurze Zusammenfassung Die Geschichte um Dr. Barry Marshall und das Bakterium Helicobacter Pylori liest sich wie ein Krimi. Ausgelacht und von der Fachwelt verspottet, sollte er schließlich und endlich sogar den Nobelpreis für Medizin erhalten. Den Status Quo in Frage stellen und der langsame Weg von der Wissenschaft in die Praxis, das soll uns diese Geschichte zeigen und ein Verständnis schaffen, warum es oft so lange dauert, bis etwas in der Praxis ankommt. Unter anderem in dieser Folge Erfahrung und Anekdoten haben in den letzten Jahrhunderten die medizinische Praxis geprägt. Erst in den letzten 15 - 20 Jahren haben wir versucht den Schritt von der “Eminenz basierten Medizin” zur “Evidenz basierten Medizin” zu gehen. Es gab nie gute klinische Studien, die die Ernährungsempfehlungen und die Ernährungspyramide, wie sie in den 1970 Jahren propagiert worden ist, und bis heute in beinahe unveränderter Form weiterhin propagiert wird, zu unterstützen. ##Hierzu auch sehr empfehlenswert, der Vortrag des Präsidenten der "World Heart Federation" Prof. Dr. Yusuf Salim und mein Blog-Artikel dazu ##Bücher Nina Teicholz, Artikel im British Medical Journal [The scientific report guiding the US dietary guidelines: is it scientific?](https://images-na.ssl-images-amazon.com/images/I/41CJE7pTAEL.SX317_BO1,204,203,200.jpg Nina Teicholz, The Big Fat Suprise A groundbreaking study that reveals how decades of misleading science and policy unjustly demonized the high-fat diet, which might actually be our healthiest option. For the past 60 years we have been told that a low-fat diet can protect against obesity, diabetes, and heart disease. Yet despite many of us taking this advice in the developed West, we are now in the midst of an obesity epidemic that is breeding serious health problems. Recent more rigorous scientific work has overturned some of the shoddier theories of earlier decades to demonstrate conclusively that we have been needlessly avoiding red meat, cheese, whole milk, and eggs for decades, and that we can now, guilt-free, welcome these delicious foods back into our lives. Quellen Nobel Lecture by Barry J. Marshall (35 minutes) Barry J. Marshall held his Nobel Lecture December 8, 2005, at Karolinska Institutet in Stockholm. He was presented by Professor Bo Angelin, Member of the Nobel Committee for Physiology or Medicine. Credits: Frekvens Produktion AB (webcasting) Copyright © Nobel Web AB 2005 Interview of Prof. Barry Marshall by Dr. Norman Swan Freakonomics Webseiten Paleo Low Carb - JULIAS BLOG | (auf Facebook folgen) Superhumanoid - PAWELS BLOG Super | (auf Facebook folgen)
In this episode, you’re going to learn the fascinating story of eventual Nobel Prize winner Dr. Barry Marshall and his lengthy fight against the general medical community who refused to accept his extensive research demonstrating the simple cause and easy cure of peptic ulcers. You’re also going to learn the gutsy (literally) stunt he pulled to finally get people to [...] The post Podcast Episode #208: What Causes Ulcers appeared first on Today I Found Out.
Bakterier förknippas ofta med fara och sjukdom. Men något håller på att hända, det forskas allt mer på deras goda sidor. Ett exempel är magsårsbakterien helicobacter pylori som blev världsberömd när Barry Marshall och Robin Warren fick nobelpriset 2005. De hade bevisat att bakterien leder till magsår som i sin tur kan orsaka magcancer och helicobacter pylori skulle utrotas med antibiotika. I dag menar kritiker att bakterien också har goda sidor och att barn som saknar den löper större risk att drabbas av astma och fetma. I veckans Kropp & Själ djupdyker vi i bakteriernas dubbla ansikte, att de kan göra oss sjuka vet vi, men på vilket sätt kan de hjälpa oss? Martin Blaser, professor i microbiologi vid New Yorks universitet, är den främsta kritikern mot bilden av magsårsbakterien helicobacter pylori som något som ska utrotas; ”Pendeln har svängt, helicobacter Pylori, har två ansikten, och vi har fokuserat för mycket på det negativa.” menar han. Även på andra håll studeras bakteriernas positiva effekter, på flera sjukhus används donerad avföring för att bota magåkommor. Genom att föra in friska bakterier i en sjuk person kan tarmfloran, i bästa fall, normaliseras. En annan fråga som studeras är huruvida allergier kan påverkas genom att mammor ges vissa bakterier under graviditeten. Thomas Abrahamsson, barnläkare och forskare vid Linköpings universitet, berättar om en stor studie där kvinnor ges mjölksyrebakterier efter den tjugonde graviditetsveckan. Gäst i studion är även professor Lars Engstrand vid Karolinska institutet som forskat om bakterier och deras påverkan på människan i över två decennium.
This week, we go back down under to explore the latest science from the land of kangaroos, bandicoots and the world's largest radio telescope - the square kilometer array. Chris goes on a tour of the universe from the comfort of the SciTech Planetarium, meets Nobel Prize-winning scientist Barry Marshall and the fluffy marsupials under protection at Project Eden. We find out why Australia is the perfect place to look further in to space than ever before, witness the battles between bee sperm and examine how tempting sharks with the scent of food can change their behaviour.
This week, we go back down under to explore the latest science from the land of kangaroos, bandicoots and the world's largest radio telescope - the square kilometer array. Chris goes on a tour of the universe from the comfort of the SciTech Planetarium, meets Nobel Prize-winning scientist Barry Marshall and the fluffy marsupials under protection at Project Eden. We find out why Australia is the perfect place to look further in to space than ever before, witness the battles between bee sperm and examine how tempting sharks with the scent of food can change their behaviour. Like this podcast? Please help us by supporting the Naked Scientists
This week, we go back down under to explore the latest science from the land of kangaroos, bandicoots and the world's largest radio telescope - the square kilometer array. Chris goes on a tour of the universe from the comfort of the SciTech Planetarium, meets Nobel Prize-winning scientist Barry Marshall and the fluffy marsupials under protection at Project Eden. We find out why Australia is the perfect place to look further in to space than ever before, witness the battles between bee sperm and examine how tempting sharks with the scent of food can change their behaviour. Like this podcast? Please help us by supporting the Naked Scientists
Guest: Barry Marshall, MBBS Host: Mary Leuchars, MD After failed attempts to infect piglets with H.pylori in 1984, Dr. Barry Marshall decided to use himself as an animal model and drank from a petri dish cultured with the bacteria. His resultant development of gastritis, and the subsequent discovery of H.pylori's role in gastric ulcer disease pathogenesis, led to a Nobel Prize in Physiology or Medicine in 2005. On this program, Dr. Marshal shares his personal story of discovery with host Dr. Mary Leuchars.
© 2020-2025 Ivy Podcast Discovery LLC
