Podcasts about Q10

CoQ10 supplementation associated with improved trauma patient outcomes Urmia University of Medical Sciences (Iran) July 23 2021.    Findings from a trial reported on July 12, 2021 in the Journal of Nutritional Science revealed benefits for hospitalized traumapatients who were given supplements that contained coenzyme Q10.  The trial enrolled 40 men and women with traumatic injury and low plasma levels of CoQ10. Participants received a placebo or 400 milligrams CoQ10 daily for seven days. Blood samples collected at the beginning and end of the trial were analyzed for interleukin 6 (IL-6), which may be elevated during inflammation, and the oxidative stress markers malondialdehyde (MDA) and thiobarbituric acid reactive substances (TBARS). Body composition was also assessed at these time points, as well secondary outcomes that included Sequential Organ Failure Assessment (SOFA) and the Glasgow Coma Scale (GCS).  While interleukin-6 levels at the beginning of the study were similar between the CoQ10 and placebo groups at an average of 175.05 pg/mL and 177.82 pg/mL, they were reduced by 76.99 pg/mL in the CoQ10 group and 17.35 pg/mL in the placebo group. MDA values averaged 232.37 picograms per milliliter (pg/mL) and 239.96 pg/mL and were lowered by 88.84 pg/ml among participants who received CoQ10 and by 26.23 pg/mL among those who received a placebo. In comparison with the placebo group, fat free mass, skeletal muscle mass and body cell mass increased among those who received CoQ10. GCS and SOFA scores, and duration of hospital stay, ICU stay and ventilator use also improved among treated patients.  “To date, no randomized clinical trial study has been conducted to evaluate the effect of CoQ10 supplementation in traumatic mechanical ventilated patients and we hypothesized that CoQ10 administration in these patients could have beneficial effects on biochemical and clinical factors,” the authors wrote. “We have shown that CoQ10 could improve some of the clinical and anthropometric parameters in patients with a traumatic injury.”     Nigella sativa (black seed) prevents covid-induced vascular damage, scientists conclude   Oriental Institute of Science and Technology (India), July 27, 2021 New research published in the journal Vascular Pharmacology shows that Nigella sativa, also known as black seed or black cumin, binds to ACE2 in the lungs, effectively stopping the Wuhan coronavirus (Covid-19) from inducing inflammation and vascular damage. Researchers out of India investigated the effects of nigellidine, an indazole alkaloid of black seed, using molecular docking for binding to different angiotensin-binding proteins, as well as the Chinese Virus spike glycoprotein. They found that nigellidine “strongly binds” to the Chinese Virus spike protein at what is known as the hinge region or active site opening, which may in turn hamper its binding to the nCoV2-ACE2 surface. “Nigellidine effectively binds in the Angiotensin-II binding site / entry pocket,” the study explains. “Nigellidine showed strong binding to mono / multi-meric ACE1.” This process of ACE blocking could, the study goes on to suggest, restore angiotensin levels and restrict vasoturbulence in Chinese Virus patients, while the receptor blocking could help to stop resulting inflammation and vascular impairment. “Nigellidine may slow down the vaso-fluctuations due to Angiotensin deregulations in Covid patients,” the paper further explains. “Angiotensin II-ACE2 binding (ACE-value -294.81) is more favorable than nigellidine-ACE2. Conversely, nigellidine-ACE1 binding-energy / Ki is lower than nigellidine-ACE2 values indicating a balanced-state between constriction-dilatation.” Nigellidine also binds to the viral spike proteins, which when taken by Chinese Virus patients, and especially those who fall in the elderly category, could greatly reduce their risk of suffering complications or death. Nigellidine impairs SARS-CoV-2 infection, “cytokine storm” through numerous mechanisms In a related study that was published last year in the journal Europe PMC, researchers learned that nigellidine inhibits the Chinese Virus infection in several other ways. It was discovered early on in the “pandemic” that many of those who tested “positive” for the virus were suffering associated “cytokine storms,” in which their immune systems were over-responding and causing more damage, or even death. Nigellidine was then studied and discovered to possess certain properties that inhibit cytokine storms, as well as impede the SARS CoV-2 virus from causing infection. It is also hepato- and reno-protective, meaning it protects against liver damage. Beyond this, nigellidine was determined to possess unique immunomodulatory and anti-inflammatory characteristics, as well as antioxidant potential strong enough to inhibit important proteins associated with the Chinese Virus. In their quest to uncover possible “drug” candidates to protect patients against hyper-inflammation and other associated problems, the researchers learned that nigellidine – and more than likely other black seed constituents – helps tremendously with preventing negative side effects. Along with nigellicine, nigellidine is found in the seed coat of Nigella sativa. Both of these constituents in their sulfated forms are extremely bioavailable, and along with thymoquinone and dithymoquinone, two other black seed components, they show strong antioxidant, antibacterial, anti-hypertensive, anti-inflammatory and immunomodulatory effects. Black seed extracts have been shown in other experiments to decrease oxidative stress, effectively lowering the risk of inflammation-related diseases. We now know that this includes the Wuhan coronavirus (Covid-19). Black seed is also recognized as a metabolic protector, helping to improve lipid and blood sugar levels. “Most importantly, in SARS CoV-2 infection ACE-2 mediated impairment of aldosterone system may be repaired by,” the study further explains, providing relevant information to the current “pandemic.” “Vasorelaxant and anti-hypertensive function of [black seed] helps in the modulation of renin angiotensin system (RAS) or the diuretic activity, which is one of the major targets of COVID. It might have great protective role during post infective secondary disorder of the peripheral vasculature namely cardiac and renal systems. In most of the instances patients die due to this organ dysfunction/failure in COVID-19 infection.” By quelling inflammation, black seed could save lives from covid Laboratory studies have found that intake of Nigella sativa significantly improves the parameters for hyperglycemia and diabetes control, as well as glycated hemoglobin and insulin resistance. Based on this, experts believe that nigellidine specifically could play an important role in fighting the Chinese Virus by “docking” to the proteins and inflammatory molecules that can cause a cytokine storm – mainly TNF-? receptors such as TNFR1, TNFR2 and IL1R. “In the experimental rat model the source of this drug Nigella sativa; black cumin seed extracts were tested for its role on antioxidant, hepatic and renal status,” the paper states. “This work will help in the urgent therapeutic intervention against COVID-19 global pandemic.” “In the current study, we have decisively shown by molecular modeling that nigellidine can bind in the active sites of several important proteins of SARS CoV 2, several host receptors specific for SARS CoV-2 induced inflammatory markers IL1, IL6, TNF-?. Moreover, the extract from black cumin seed has been shown in experimental rat to be highly antioxidative, hepato- and reno-protective. Further studies are necessary to verify the potential effects of nigellidine in in vivo laboratory experimental animal model.”   Vitamin D supplementation improves recovery time of children with pneumonia at pediatric hospital Cairo University (Egypt), July 20, 2021 According to news reporting originating from Cairo, Egypt, by NewsRx correspondents, research stated, “Despite the well-recognized effect of vitamin D in metabolism and homeostasis, there is now growing interest in its probable association with pneumonia. This study aims to supply vitamin D3 (Cholecalciferol) (100,000 IU) to pneumonic children to minimize the duration of illness and improve their outcome.” Our news editors obtained a quote from the research from Cairo University, “A double-blinded, randomized, placebo-controlled trial was conducted in a Pediatric Cairo University affiliated hospital. An intervention arm (93 children) and a control arm (98 children), who had pneumonia with an insufficient or deficient level of vitamin D and whose parental permission was obtained, were enrolled in the trial. All children were treated with antibiotics according to WHO guidelines. Children were given a single injection of 1 mL of 100,000 IU of vitamin D3 or placebo. Clinical data were recorded every eight hours for all children. Outcomes were assessed 7 days after vitamin D injection. The primary outcome variable was the change in serum level of 25(OH)D, while the secondary outcomes were the medical state of the assigned cases (improvement or death) and duration between enrollment and hospital discharge for improved cases. In the supplementation group, the percentage of patients who suffered either deficient (38.7%) or insufficient levels (61.3%) of 25 (OH)D at day one had significantly decreased in the seventh day to (11.8%) and (52.7%), respectively. Kaplan--Meier plots highlighted that the median time to recover of the placebo group was significantly longer than that of the supplementation group (Log Rank P value < .001). VDD was detected in pediatric critical care children.” According to the news editors, the research concluded: “In pneumonic children with high VDD, it is illustrated that Vitamin D supplementation is accompanied by lowered mortality risk and pSOFA scores, reduced time to recover, and improved PaO2/FiO(2).”   Physical activity could combat fatigue, cognitive decline in cancer survivors University of Illinois, July 26, 2021 A new study indicates that cancer patients and survivors have a ready weapon against fatigue and "chemo brain": a brisk walk. Researchers at the University of Illinois, along with collaborators at Digital Artefacts in Iowa City, Iowa, and Northeastern University in Boston, looked at the association between physical activity, fatigue and performance on cognitive tasks in nearly 300 breast cancer survivors. "The data suggest that being more physically active could reduce two of the more commonly reported symptoms in breast cancer survivors: fatigue and cognitive impairment," said study leader Edward McAuley, a professor of kinesiology and community health at Illinois. "Most people think, 'If I exercise, I'll become tired.' In our study, exercise actually was associated with reduced fatigue, which in turn was associated with better cognitive function." Cognitive impairment, such as memory problems or shortened attention spans, is a common complaint among cancer patients and survivors, and is thought to be similar to decline due to aging. Past Illinois research has explored the effect of physical fitness on age-related cognitive decline, so the researchers wondered whether cancer survivors would respond similarly to exercise. "Other studies of cancer survivors have relied on small samples of cancer survivors, and used self-reporting measures of physical activity and cognitive function, which can be very biased," said postdoctoral researcher Diane Ehlers, the first author of the study, which is published in the journal Breast Cancer Research and Treatment. "What makes our study novel is that we had objective measures for both physical activity and cognitive performance, and a nationwide sample of breast cancer survivors." The researchers worked with Digital Artefacts -- developer of the commercial neuroscience app BrainBaseline - to create an iPad app tailored to this study. The app included questionnaires and activities designed to measure attention, memory and multitasking skills. The researchers also sent each participant an accelerometer to track daily physical activity. "We found that higher levels of daily moderate-to-vigorous physical activity were associated with better performance on the cognitive tasks measuring attention, memory and multitasking," Ehlers said. "What was notable was that physical activity's effect on cognitive performance was mediated by fatigue. This provides evidence that physical activity interventions targeting fatigue in cancer patients and survivors might provide promising models for improving cognitive function as well." Next, the researchers plan to conduct further studies to establish causation and further explore the pathways of how physical exercise improves cognitive performance. They are working with Digital Artefacts to conduct an iPhone-based study and focusing on diverse populations of breast cancer survivors. "The message for cancer patients and survivors is, get active!" Ehlers said. "Even if it's 10-minute bouts of brisk walking. It's not a magical cure-all, but we've seen many benefits of physical activity for cancer patients and survivors."   Cannabidiol promotes oral ulcer healing by inactivating CMPK2-mediated NLRP3 inflammasome Sichuan University (China), July 26, 2021 Xingying Qi, West China Hospital of Stomatology, Sichuan University, Chengdu, China, presented the oral session "Cannabidiol Promotes Oral Ulcer Healing by Inactivating CMPK2-Mediated NLRP3 Inflammasome" at the virtual 99th General Session & Exhibition of the International Association for Dental Research (IADR), held in conjunction with the 50th Annual Meeting of the American Association for Dental Research (AADR) and the 45th Annual Meeting of the Canadian Association for Dental Research (CADR), on July 21-24, 2021. The oral ulcer is a common oral inflammatory lesion with severe pain but little effective treatment is currently available. Cannabidiol (CBD) is recently emerging as a therapeutic agent for inflammatory diseases. However, the underlying mechanisms are not fully elucidated. Qi and colleagues sought to investigate whether and how CBD could play a therapeutic role in the oral ulcer. Oral ulcer models were performed in the tongue of C57BL/6 mice by acid etching or mechanical trauma, followed by CBD local administration. Samples were harvested for macroscopic and histological evaluation. CBD oral spray on acid- or trauma-induced oral ulcers on mice tongues inhibited inflammation, relieved pain and accelerated lesions closure in a dose-dependent manner. The results show that CBD accelerates oral ulcer healing by inhibiting CMPK2-mediated NLRP3 inflammasome activation and pyroptosis, which is mediated mostly by PPARγ in nucleus and partially by CB1 in plasma membrane. This data may shed light on the development of new therapeutic strategies for oral ulcers.   Algal solution: Could Spirulina modify the microbiome to protect against age-related damage? Louvain Drug Research Institute (Belgium), July 25 2021 Spirulina might help protect against age-related liver inflammation by modifying pathways in the microbiome, say researchers. Consumption of spirulina could help protect against hepatic inflammation in the elderly, according to the new animal research published in Nutrients. Belgian researchers carried out tests on mice, which suggest that the algae Spirulina has an impact on the gut microbiota, which in turn activates the immune system in the gut and improves inflammation in the liver that is associated with ageing. Led by senior author Professor Nathalie Delzenne from the Louvain Drug Research Institute in Belgium, the team said oral feeding of Spirulina was found to modulates several immunological functions involving, among others, the TLR4 pathway in old mice. “The fact that its oral consumption can influence both gut immunity and systemic sites, such as the liver, suggests that its immune action is not confined to the gut immune system,” wrote the team – who said the findings open the way to new therapeutic tools “in the management of immune alterations in aging, based on gut microbe-host interactions.” Furthermore, they suggested that improvement of the homeostasis in the gut ecosystem ‘could be essential' during the aging process, “and, in this perspective, dietary manipulation of the gut microbiota of the elderly with Spirulina, may represent a tool for preserving a healthy gastrointestinal microbial community in addition to its beneficial effects on immune function.” Study details Delzenne and colleagues noted that while the possible cardiovascular and immune support benefits of Spirulina have been fairly widely reported, the new study brings a fresh approach by testing whether the effects could be related to a modulation of gut micrbiota. In the trial, young mice aged three months were fed a standard diet, while older mice aged 24 months were fed a standard diet either with or without 5% Spirulina for six weeks. Upton supplementation with Spirulina, the team reported several changes to gut microbiota composition, including an increase in Roseburia and Lactobacillus populations. “Interestingly, parameters related to the innate immunity are upregulated in the small intestine of Spirulina-treated mice,” said the team. “Furthermore, the supplementation with Spirulina reduces several hepatic inflammatory and oxidative stress markers that are upregulated in old mice versus young mice.” Expression of several genetic and biochemical markers of inflammation and immunity were altered by supplementation with Spirulina, said the team. In particular, the transcription factor Foxp3 – involved in the differentiation of T cells into regulatory T cells (Tregs) – and MCP1 were increased due to Spirulina supplementation in old mice. Old mice that consumed Spirulina also showed activation of several immune parameters including Foxp3 in the ileum – suggesting an improvement of the gut immune function upon Spirulina treatment in this segment, said the Belgian researchers. Furthermore, Spirulina supplementation upregulated both TLR2 and TLR4 expression in the ileum of aged mice. “In accordance with these results, a solution of Spirulina (5%) exhibited a TLR4 agonist activity similar to the one reached in old-SP mice, suggesting a direct effect of the Spirulina, itself, on the TLR4 pathway,” they added. Microbiome mechanisms While the positive effect of Spirulina on the microbiome and liver inflammation is clear, the team noted that the mechanism by which the algae could change the composition of the intestinal microbiota remains unanswered. One possible mechanism could be the presence of antimicrobial substances produced by Spirulina, they said. “On the other hand, antimicrobial peptides (AMPs) could be mediators of the nutritional modulation of the gut microbiota.” “In the present study, RegIIIγ and Pla2g2 were increased by the supplementation with Spirulina, suggesting that the host contributes to the reduction and modification of the microbial community by modulating the production of specific AMPs,” they added.

Goodie & Shantel are back with another in-depth Recap of Starz- Power Book 3 - Raising Kanan S1 Episode 2; press play; tell a friend to tell a friend! #starz #power #raisingkanan #southside #southsidejamaicaqueens #southjamaica #jamaicaqueens #qgtm #baisleypark #Q10

Ich habe es endlich geschafft Dr. Thomas Peter für ein Podcast-Interview ans Mikrofon zu bekommen! Wir sprechen darüber wie er zu seinem Beruf gefunden hat, warum er Next Vital gegründet hat und welche Werte man sich bei einer Blutuntersuchung anschauen lassen sollte. Außerdem sprechen wir über Themen wie Nebennierenschwäche und Schilddrüsenunterfunktion. Außerdem habe ich ihm Eure Fragen gestellt: Kann man Bauchschmerzen von EAA‘s bekommen? Kann Magnesium Blähungen und Verdauungsprobleme machen? Wieso empfiehlst Du (und auch ich) Q10? Iron Support bei Ferritin von 11 auch in der Stillzeit? Kupfermangel im Blut und Überschuss in der Haarmineralanalyse, was tun? Wadenkrämpfe trotz Magnesium und Sportpausen. Ursache? Ich wünsche Dir viel Spaß beim reinhören. ——————————————————— Im Podcast erwähnt (enthält Werbung): Dr. Thomas Peter: Instagram: dr.thomaspeter Website: www.anuvindati.de Next Vital: Mein Rabattcode lautet: Hannah10 Webiste: www.nextvital.de Eisen Magnesium Basic Minerals Next Vital Academy ——————————————————— Du möchtest keine Folge verpassen und zusätzliche Tipps direkt in dein Email Postfach bekommen? Dann melde Dich für meinen Newsletter an und erhalte meine 11 darmfreundlichen Rezepte die auch Meal Prep geeignet sind. Newsletter & Freebie Deine Gedanken zu meinem Podcastfolge kannst Du mir gerne auf Instagram unter dem Post mitteilen oder auch per Mail zusenden: info@hannah-willemsen.com. Du würdest mir einen riesen Gefallen tun, wenn Du meinen Podcast auf iTunes mit 5 Sternen bewertest. So finden andere diesen Podcast auch und erhalten ebenfalls wertvolle Tipps zum Thema gesunde Ernährung. Alles Liebe Deine Hannah

主持人：詩瑋 來賓：孫國倫 藥師 主題：保健品與三高藥可一起吃？ 很多民眾都有服用慢性三高用藥，那該如何跟保健食品一起吃呢？紅麴、銀杏、葡萄糖胺、益生菌、Q10膠原蛋白、綜合維他命等會有影響嗎？有需要配合補充服用嗎？會減少藥效嗎？該在飯前或飯後吃？讓孫國倫藥師告訴你！ 節目時間：週一至週日 11:00am-12:00pm 本集播出日期：2021.07.14 ----　 ▍九八新聞台@大台北地區 FM98.1 ▍官網：http://www.news98.com.tw ▍粉絲團：https://www.facebook.com/News98 ▍線上收聽：https://pse.is/R5W29 ▍APP下載 • APP Store：https://news98.page.link/apps • Google Play：https://news98.page.link/play ▍YouTube頻道：https://www.youtube.com/user/News98radio ▍Podcast • Himalaya：https://www.himalaya.com/news98channel • Apple Podcast：https://goo.gl/Y8dd5F • SoundCloud：https://soundcloud.com/news98

I invited our Mind Your Autistic Brain community to send in their questions about burnout and I hosted a very casual zoom to answer them. We ended up with 13 questions in this episode and I hope it is as helpful to you as it was to the group. The poll results showed that the majority weren't sure if they were in burnout at the beginning of the webinar and wanted to learn more and when I asked at the end if those who answered they weren't sure now had clarity the results were very clear, yes burnout was definitely on the radar now. Time Stamps: Q1- 4:11 What is Autstic Burnout? Q2- 7:40 How can I help someone who is going through burnout? Q3- 10:51 What's the recovery journey look like? Where to start? What's the 1st step? Q4- 18:16 I have a long to do list, events and travel coming up and I'm feeling drained. Q5- 21:46 I have felt more distant & have no will to be social, is this an early sign? Q6- 26:12 Is there any way of getting motivated while in burnout? Q7- 31:43 At what age can burnout start? Q8- 34:44 How long or short could it be? How much can burnout vary? Q9- 37:44 How do I make peace with the me who was in burnout? Q10- 39:57 I've always thought I suffer from depression but could this be burnout? Q11- 43:20 Can medications make a difference and could this still be burnout? Q12- 47:19 How do I prioritize myself? Q13- 49:22 How do I recognize BO warning signs? How do I manage BO while still working full time? Mind Your Autistic Brain Talk Show hosted by The Social Autie, that's me, Carole Jean. I am a late identified, adult autistic and each week I have a conversation with another late identified autistic, who shares their voice, experiences and journey with you. I am only one voice among many and I can't wait to share my incredible friends with you and let you know that you are not alone on this autism journey, we are here with you. Join us each Wednesday on your favorite platform. Be sure to subscribe so you don't miss the latest episode and if you are loving the show, please take a moment to give a 5 star rating (If I've earned it) and a review on your listening platform or a comment under the video. Help your friend who is just starting their autism journey and share the show with them too. We all need a helping hand and a friend looking out for us. Be that friend. We look forward to hearing what you think and what you've learned each week. If you or someone you know would be a great guest to share their story on the show please send me an email at: carolejeanw@socialautie.com SUBJECT LINE: GUEST Visit me on the web at: www.socialautie.com f you are enjoying the show and it has been helpful to you in any way, please consider sponsoring me either by a monthly contribution via Anchor or through a one time sponsorship via Buy Me a Coffee https://www.buymeacoffee.com/socialautie --- Support this podcast: https://anchor.fm/socialautie/support

Sunflower peptide as 'template' for potential analgesic Medical University of Vienna (Austria), June 28, 2021 A naturally occurring peptide in sunflower seeds was synthetically optimised and has now been identified as a potential drug for treating abdominal pain or inflammation (in the gastrointestinal tract, abdominal area and/or internal organs). That is the finding of an international study led by Christian Gruber from MedUni Vienna's Institute of Pharmacology (Center for Physiology and Pharmacology), which was conducted jointly with the University of Queensland and Flinders University in Australia and has now been published. The scientific aim of the study is to find analgesics that are only active in the periphery and do not cross the blood-brain barrier, as an alternative to commonly used synthetic opioids. Gruber explains the background: "Morphine was one of the first plant-based medicines and was isolated from the dried latex of poppies more than 200 years ago. It binds to opioid receptors in the brain and is still regarded as the main pillar of pain therapy. However, there is a high risk of opioid addiction, and an overdose - as a result of this strong dependency - inhibits the breathing centre in the brain, which can result in respiratory depression and, in the worst case, in death." For this reason, researchers throughout the world are trying to make analgesics safer and to find active drug molecules that do not have the typical opioid side-effects.  Sunflower extracts were to some extent used in traditional medicine for their anti-inflammatory and analgesic properties. In the current study, the scientists from Austria and Australia, primarily PhD student Edin Muratspahi?, isolated the plant molecule that may be responsible for this effect. Medicinal chemistry methods were then used to optimise the so-called sunflower trypsin inhibitor-1 (SFTI-1), one of the smallest naturally occurring cyclic peptides, by 'grafting' an endogenous opioid peptide into its scaffold.  A total of 19 peptides were chemically synthesized based on the original SFTI-1 blueprint and pharmacologically tested. "One of these variants turned out to be our lead candidate for as potential innovative analgesic molecule, especially for pain in the gastrointestinal tract or in the peripheral organs. This peptide is extremely stable, highly potent and its action is restricted to the body's periphery. Its use is therefore expected to produce fewer of the typical side-effects associated with opioids," point out Gruber and Muratspahi?.  The mode-of-action of the peptide is via the so-called kappa opioid receptor; this cellular protein is a drug target for pain relief, but is often associated with mood disorders and depression. The sunflower peptide does not act in the brain, hence there is much less risk of dependency or addiction. Furthermore, it selectively activates only the molecular signalling pathway that influences pain transmission but does not cause the typical opioid side-effects. The data of the animal model in the current study are very promising: the scientists see great potential for using this peptide in the future to develop a safe medication - which could be administered orally in tablet form - to treat pain in the gastrointestinal tract, and this drug could potentially also be used for related painful conditions, e.g. for inflammatory bowel disease.  Using Nature's blueprint The research of this MedUni Vienna laboratory led by Christian Gruber exploits the concept of using Nature's blueprint to develop optimised drugs. "We are searching through large databases containing genetic information of plants and animals, decoding new types of peptide molecules and studying their structure, with a view to testing them pharmacologically on enzymes or membrane receptors and ultimately utilizing them in the disease model," explains Gruber. Finally, potential drug candidates are chemically synthesised in a slightly modified form based on the natural blueprint, to obtain optimised pharmacological properties.   Study associates organic food intake in childhood with better cognitive development Analysis of multiple prenatal and childhood environmental risk factors suggests that poor nutrition, house crowding and indoor air pollution are associated with poorer cognitive function Barcelona Institute for Global Health (Spain), July 1, 2021 A study analysing the association between a wide variety of prenatal and childhood exposures and neuropsychological development in school-age children has found that organic food intake is associated with better scores on tests of fluid intelligence (ability to solve novel reasoning problems) and working memory (ability of the brain to retain new information while it is needed in the short term). The study, published in Environmental Pollution, was conceived and designed by researchers at the Barcelona Institute for Global Health (ISGlobal)--a centre supported by the "la Caixa" Foundation--and the Pere Virgili Health Research Institute (IISPV-CERCA).  The explanation for this association may be that "healthy diets, including organic diets, are richer than fast food diets in nutrients necessary for the brain, such as fatty acids, vitamins and antioxidants, which together may enhance cognitive function in childhood," commented lead author Jordi Júlvez, a researcher at IISPV-CERCA who works closely with ISGlobal.  The study also found that fast food intake, house crowding and environmental tobacco smoke during childhood were associated with lower fluid intelligence scores. In addition, exposure to fine particulate matter (PM2.5) indoors was associated with lower working memory scores.  The study, titled "Early life multiple exposures and child cognitive function: A multi-centric birth cohort study in six European countries", used data on 1,298 children aged 6-11 years from six European country-specific birth cohorts (United Kingdom, France, Spain, Greece, Lithuania and Norway). The researchers looked at 87 environmental factors the children were exposed to in utero (air pollution, traffic, noise, various chemicals and lifestyle factors) and another 122 factors they were exposed to during childhood. A Pioneering Study The aim of the study was to analyse the influence of these exposures on the development and maturation of the human brain, since during childhood the brain is not yet fully developed for efficient defence against environmental chemicals and is particularly sensitive to toxicity, even at low levels that do not necessarily pose a risk to a healthy mature brain.  The originality of the study lies in its use of an exposome approach, i.e. the fact that it takes into account the totality of exposures rather than focusing on a single one. This approach aims to achieve a better understanding of the complexity of multiple environmental exposures and their simultaneous effect on children's neurodevelopment.  Another strength of the study, which analyses cohorts from six European countries, is its diversity, although this factor also poses the additional challenge of cultural differences, which can influence exposure levels and cognitive outcomes. Notable Associations The study found that the main determinants of fluid intelligence and working memory in children are organic diet, fast food diet, crowdedness of the family home, indoor air pollution and tobacco smoke. To date, there has been little research on the relationship between type of diet and cognitive function, but fast food intake has been associated with lower academic development success and some studies have also reported positive associations between organic diets and executive function scores. "In our study," explained Júlvez, "we found better scores in fluid intelligence and working memory with higher organic food intake and lower fast food intake."  In contrast, exposure to tobacco smoke and indoor PM2.5 during childhood may negatively affect cognitive function by enhancing pro-inflammatory reactions in the brain. Still, according to Júlvez, it is worth bearing in mind that "the number of people living together in a home is often an indicator of the family's economic status, and that contexts of poverty favour less healthy lifestyles, which in turn may affect children's cognitive test scores".  Some Surprising Findings  The study also found some unexpected associations, which could be explained by confounding and reverse causality. For example, a positive association was found between childhood exposure to perfluorooctane sulfonic acid (PFOS) and cognitive function, even though PFOS is considered an endocrine disruptor that may alter thyroid function and negatively influence cognitive development.  The study forms part of the large European project Human Early-Life Exposome (HELIX), as does another recent paper that used the same exposome and the same participants but looked at symptoms of attention deficit hyperactivity disorder (ADHD) and childhood behavioural problems. "We observed that several prenatal environmental pollutants (indoor air pollution and tobacco smoke) and lifestyle habits during childhood (diet, sleep and family social capital) were associated with behavioural problems in children," explained Martine Vrijheid, last author of the study and head of ISGlobal's Childhood and Environment programme. "One of the strengths of this study on cognition and the earlier study on behavioural problems is that we systematically analysed a much wider range of exposure biomarkers in blood and urine to determine the internal levels in the model and that we analysed both prenatal and childhood exposure variables," concluded Vrijheid.     Extract of mulberry leaves partially restores the composition of intestinal microbiota and strengthens liver glycogen fragility in diabetic rats Macau University of Science and Technology (China), June 28, 2021 According to news reporting out of Macau, People's Republic of China, research stated, “Mulberry leaf as a traditional Chinese medicine is able to treat obesity, diabetes, and dyslipidemia. It is well known that diabetes leads to intestinal microbiota dysbiosis.” Our news journalists obtained a quote from the research from the Macau University of Science and Technology, “It is also recently discovered that liver glycogen structure is impaired in diabetic animals. Since mulberry leaves are able to improve the diabetic conditions through reducing blood glucose level, it would be interesting to investigate whether they have any positive effects on intestinal microbiota and liver glycogen structure. In this study, we first determined the bioactive components of ethanol extract of mulberry leaves via high-performance liquid chromatography (HPLC) and liquid chromatography/mass spectrometry (LC/MS). Murine animal models were divided into three groups, normal Sprague-Dawley (SD) rats, high-fat diet (HFD) and streptozotocin (STZ) induced type 2 diabetic rats, and HFD/STZ-induced rats administered with ethanol extract of mulberry leaves (200 mg/kg/day). Composition of intestinal microbiota was analyzed via metagenomics by sequencing the V3-V4 region of 16S rDNAs. Liver glycogen structure was characterized through size exclusion chromatography (SEC). Both Student's t-test and Tukey's test were used for statistical analysis. A group of type 2 diabetic rat models were successfully established. Intestinal microbiota analysis showed that ethanol extract of mulberry leaves could partially change intestinal microbiota back to normal conditions. In addition, liver glycogen was restored from fragile state to stable state through administration of ethanol extract of mulberry leaves. This study confirms that the ethanol extract of mulberry leaves (MLE) ameliorates intestinal microbiota dysbiosis and strengthens liver glycogen fragility in diabetic rats.” According to the news editors, the research concluded: “These finding can be helpful in discovering the novel therapeutic targets with the help of further investigations.”     Supplemental antioxidants may reduce exacerbations in cystic fibrosis     University of Colorado, July 2, 2021 An antioxidant-enriched vitamin may decrease respiratory exacerbations in people with cystic fibrosis(CF), according to new research published online iin the American Journal of Respiratory and Critical Care Medicine. In "Effects of an Antioxidant-Enriched Multivitamin in Cystic Fibrosis: Randomized, Controlled, Multicenter Trial," Scott D. Sagel, MD, PhD, a professor of pediatrics at Children's Hospital Colorado and director of the University of Colorado Cystic Fibrosis Center, and coauthors report a 50 percent reduced risk of time to the first exacerbation requiring antibiotics in those receiving the supplemental antioxidants. During the 16-week study of 73 patients (36 received supplemental antioxidants), 53 percent of the antioxidant-treated group experienced 28 exacerbations, compared to 68 percent of the control group who experienced 39 exacerbations. The researchers also found that supplemental antioxidants increased circulating antioxidant concentrations of beta-carotene, coenzyme Q10, gamma-tocopherol (a form of vitamin E) and lutein and transiently decreased inflammation (at 4 weeks, but not 16 weeks) as measured by two blood-based biomarkers of inflammation, calprotectin and myeloperoxidase (MPO). People with CF typically experience chronic bacterial infections, which lead to inflammation and the release of "vast amounts of reactive oxygen species in the airways," the authors wrote. Normally, they added, the body would marshal an antioxidant defense to neutralize this oxidant stress, but CF is characterized by dietary antioxidant deficiencies. This contributes to an oxidant-antioxidant imbalance and more inflammation, which leads to lung damage and a progressive loss of lung function. "Improving antioxidant status in CF is an important clinical goal and may have a positive effect on health," Dr. Sagel said. "Oral antioxidant formulations had been tested in CF with mixed results. However, there had not been a well-designed randomized controlled trial of an antioxidant 'cocktail' that included multiple antioxidants in a single formulation." This phase 2 trial, conducted at 15 CF centers affiliated with the CF Foundation Therapeutics Development Network, enrolled patients who were 10 years and older (average age 22 years), with pancreatic insufficiency, which causes malabsorption of antioxidants. Participants had an FEV1, the measure of how much air can be forcefully exhaled in one second, between 40 and 100 percent of what would be predicted, based on age, gender, height and a range of other characteristics. Patients in the control group received a multivitamin without antioxidant enrichment. The two groups tolerated their vitamins equally well, and there were no differences in adverse events between the two groups. The study did not meet its primary endpoint: change in sputum MPO concentration over 16 weeks. The authors chose sputum MPO "rather than another marker of airway inflammation such as neutrophil elastase because MPO generates reactive oxidant species as part of its function in innate host defense mechanisms, and is considered by many a marker of oxidative stress." "While the antioxidant supplement did not appear to exert sustained anti-inflammatory effects, we believe its effect on time to first pulmonary exacerbation was significant and clinically meaningful," Dr. Sagel said, adding that the improvement in antioxidant status alone may justify its use. "Developing safe and effective anti-inflammatory treatments remains a key priority of the CF community."   Maternal diets rich in Omega-3 fatty acids may protect offspring from breast cancer Marshall University School of Medicine, June 28, 2021 According to researchers at Marshall University, a maternal diet rich in Omega-3 fatty acids protects from breast cancer development in offspring. In a new studyrecently published by Frontiers in Cell and Developmental Biology, researchers noted a significant difference in mice from mothers that were fed a diet rich in canola oil, compared with mothers fed a diet rich in corn oil. A maternal Omega 3-rich diet affected genome-wide epigenetic landscape changes in offspring and potentially modulated gene expression patterns. Dr. Ata Abbas, a former postdoctoral research fellow in Marshall's Department of Biological Sciences, headed a research team under the leadership of Dr. Philippe Georgel in the College of Science. Research was done in the Cell Differentiation and Development Center at Marshall as part of a collaborative effort with the Joan C. Edwards School of Medicine's Department of Biochemistry and Microbiology, under the leadership of Dr. W. Elaine Hardman. Researchers noticed a three-week delay in mortality in mice whose mothers were fed canola oil versus corn oil. The early delay in mortality was significantly different, but the ultimate overall survival rate was not. Eventually, all the mice developed tumors, but the ones fed canola oil had tumors that were slower-growing and smaller than the mice fed corn oil. Translated to human time scale, the duration of the protective effect linked to the maternal diet would be equivalent to several months (Sengupta et al., 2016). This study is among a body of work done by Marshall University scientists and others looking at the link between Omega-3 fatty acids and reduced incidence of various types of cancer including, but not restricted to, Chronic Lymphocytic Leukemia and Diffuse Large B-Cell Lymphoma. "The issue of parental diet and inter-generational transmission has become an important field of research; however, the mode of action often remains partially elusive," said Georgel, a professor in the Department of Biological Sciences at Marshall. "The MU research group focused on 'epigenetic' aspects of trans-generational transmission to explain the reported role of Omega-3 fatty acids. Epigenetics involves changes in gene expression which are not linked to changes in genetic sequences. These results have the potential to promote the design of simple changes in diet which would allow for reduced onset of various types of cancer, not only for the individuals using that diet but also for their offspring."     Compounds found in green tea and wine may block formation of toxic metabolites Tel Aviv University (Israel), July 2, 2021 A new Tel Aviv University study suggests there is hope of treating certain inborn congenital metabolic diseases -- a hope found in green tea and in red wine. Most people with inherited metabolic disorders are born with a defective gene that results in a critical enzyme deficiency. In the absence of a cure, many patients with inborn congenital metabolic disorders must adhere to a strict and demanding diet their entire lives. This new research finds that certain compounds found naturally in green tea and red wine may block the formation of toxic metabolites. The research was led by Prof. Ehud Gazit of TAU's Faculty of Life Sciences and his doctoral student Shira Shaham-Niv. It was published in the Nature group journal Communications Chemistry. The researchers considered two compounds: (1) epigallocatechin gallate, known as EGCG, found naturally in green tea, which has attracted attention within the medical community for its potential health benefits; and (2) tannic acid, found in red wine, which is known to prevent the formation of toxic amyloid structures that cause neurodegenerative disorders such as Alzheimer's and Parkinson's disease. "In the case of inborn congenital metabolic diseases, the body does not produce a vital metabolic enzyme," Shaham-Niv said. "As a result, metabolites -- substances that are, among other things, the building blocks of DNA and proteins -- accumulate in the body. Such uncontrolled accumulation is toxic and can cause severe developmental and mental disorders. "Our new study demonstrates once again the ability of nature to produce the best candidate of drugs to treat some of the worst human maladies." Collectively, this group of disorders constitutes a significant portion of pediatric genetic diseases. The disease phenylketonuria (PKU), which produces the aggregation of the metabolite phenylalanine, is one common inborn metabolic disease. Infants with PKU must adhere to a strict diet free of phenylalanine for the rest of their lives. If they don't, they may face severe debilitating developmental problems. "But this is an incredibly difficult task, since phenylalanine is found in most of the food products that we consume," Shaham-Niv said. "The avoidance of certain substances is the only way to prevent the debilitating long-term effects of inborn congenital metabolic disorders. We hope that our new approach will facilitate the development of new drugs to treat these disorders." The new research is based on two previous studies conducted at Prof. Gazit's TAU laboratory. In the first study, phenylalanine was shown to be capable of self-assembly and of forming amyloid structures like those seen in Alzheimer's, Parkinson's and other neurodegenerative diseases. In the second study, by Shaham-Niv, other metabolites that accumulate in other inborn congenital metabolic diseases were also shown to undergo self-assembly processes and form toxic amyloid aggregates. "Both studies led to an overhaul in the research community's understanding of metabolic diseases," Shaham-Niv said. "In our new study, we examined whether the molecules identified in past studies on Alzheimer's disease and other amyloid diseases, which are known to inhibit the formation of amyloid aggregates, could also help counteract the amyloid formation process of metabolites in metabolic diseases." The new research focused on EGCG and tannic acid using test tubes and culture cell systems. The two substances were tested on three metabolites related to three innate metabolic diseases: adenine, cumulative tyrosine and phenylalanine. The results were promising. Both tannic acid and EGCG were effective in blocking the formation of toxic amyloid structures. The researchers also used computer simulations to verify the mechanism driving the compounds. "We are entering a new era of understanding the role and the importance of metabolites in various diseases, including metabolic diseases, neurodegenerative diseases and even cancer," Shaham-Niv concluded. "The tools we have developed are ground-breaking and have tremendous potential to help a wide range of patients in the future."       People with fibromyalgia are substituting CBD for opioids to manage pain University of Michigan, June 24, 2021 Fibromyalgia is one of many chronic pain conditions that remains stubbornly difficult to treat.  As the ravages of the opioid epidemic lead many to avoid these powerful painkillers, a significant number of people with fibromyalgia are finding an effective replacement in CBD-containing products, finds a new Michigan Medicine study.  CBD, short for cannabidiol, is the second most common cannabinoid in the cannabis plant, and has been marketed for everything from mood stabilization to pain relief, without the intoxicating effects produced by the most common cannabinoid, THC. THC, which stands for delta-9-tetrahydrocannabinol, is the ingredient in marijuana that causes people to feel high. The cannabis industry has exploded, aided by the legalization of medical and recreational marijuana in states around the United States and the removal of hemp-derived CBD from Schedule 1 status--reserved for drugs with no currently accepted medical use and a high potential for abuse--at the federal level.  Previous research shows that some people substitute medical cannabis (often with high concentrations of THC) for opioids and other pain medications, reporting that cannabis provides better pain relief and fewer side effects. However, there is far less data on CBD use. "CBD is less harmful than THC, as it is non-intoxicating and has less potential for abuse," said Kevin Boehnke, Ph.D., a research investigator in the Department of Anesthesiology and the Chronic Pain and Fatigue Research Center. "If people can find the same relief without THC's side effects, CBD may represent a useful as a harm reduction strategy." Boehnke and his team surveyed people with fibromyalgia about their use of CBD for treatment of chronic pain.  "Fibromyalgia is not easy to treat, often involving several medications with significant side effects and modest benefits," Boehnke explained. "Further, many alternative therapies, like acupuncture and massage, are not covered by insurance." For this study, the team focused on 878 people with fibromyalgia who said they used CBD to get more insight into how they used CBD products.  The U-M team found that more than 70% of people with fibromyalgia who used CBD substituted CBD for opioids or other pain medications. Of these participants, many reported that they either decreased use or stopped taking opioids and other pain medications as a result.  "I was not expecting that level of substitution," said Boehnke, noting that the rate is quite similar to the substitution rate reported in the medical cannabis literature. People who said they used CBD products that also contained THC had higher odds of substitution and reported greater symptom relief. Yet the finding that products containing only CBD also provided pain relief and were substituted for pain medications is promising and merits future study, noted Boehnke.  The team noted that much of the widespread use of CBD is occurring without physician guidance and in the absence of relevant clinical trials. "Even with that lack of evidence, people are using CBD, substituting it for medication and doing so saying it's less harmful and more effective," he said.  Boehnke stressed the need for more controlled research into how CBD may provide these benefits, as well as whether these benefits may be due to the placebo effect.  Clinically, opening up lines of discussion around CBD use for chronic pain is imperative, said Boehnke, for medication safety reasons as well as for "enhancing the therapeutic alliance and improving patient care."

Después de estar muchos años trabajando para una multinacional, Oscar Llansó traslada todos sus conocimientos a nivel empresarial a la oficina de farmacia donde desarrolla la categoría de complementos nutricionales para mejorar el consejo de salud. En el podcast Oscar nos habla de cinco complementos muy Interesantes para recomendar en la farmacia: glutamina, enzimas digestivos, Rhodiola, coenzima Q10, depurativos hepáticos.

Whether you are on a statin, dealing with arrhythmia or trying to conceive, you're going to want to listen to this jam packed episode all about CoQ10! CoQ10 is an antioxidant that is produced endogenously (meaning it can be made in the body) that plays a vital role in cardiovascular health, prevention of oxidative stress, regulation of inflammation and fertility. Tune in to hear Ali and Becki discuss the difference between ubiquinone and ubiquinol as well as considerations for supplementation and best food sources of CoQ10.    In this episode Ali and Becki break down the function of CoQ10 in the body from supporting the heart, kidneys and skeletal muscles to its essential role in preserving fertility in men and women and so much more. We also cover concerns for myocarditis and the shmaxxmine and how CoQ10 has shown improvement in this condition. Plus learn about CoQ10 rich food sources and why you need to be eating more organs!   Use code COQ10PODCAST for 15% off your first bottle of CoQ10 Complex!    Also in this episode:    Episode 85: 3 Micronutrients: Asparagine, CoQ10, Zinc What is CoQ10? Micronutrient Panel The Truth About Ubiquinone vs. Ubiquinol and Bioavailability  Benefits of CoQ10 Symptoms of CoQ10 Deficiency Why Statin Drugs Deplete CoQ10 Cardiovascular HealthThe effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial Effect of coenzyme Q10 therapy in patients with congestive heart failure: a long-term multicenter randomized study Atorvastatin Decreases the Coenzyme Q10 Level in the Blood of Patients at Risk for Cardiovascular Disease and Stroke Effect of coenzyme Q10 on the incidence of atrial fibrillation in patients with heart failure Coenzyme Q10 in essential hypertension Coenzyme Q10 in Cardiovascular and Metabolic Diseases: Current State of the Problem  FertilityCoenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging Coenzyme Q10 and male infertility: a meta-analysis Antioxidant supplements and semen parameters: An evidence based review Pretreatment with coenzyme Q10 improves ovarian response and embryo quality in low-prognosis young women with decreased ovarian reserve: a randomized controlled trial Neurological Health Coenzyme Q10 and neuropsychiatric and neurological disorders: relevance for schizophrenia Coenzyme Q10 decreases amyloid pathology and improves behavior in a transgenic mouse model of Alzheimer's disease Energy & Exercise RecoveryEffects of coenzyme Q10 on arterial stiffness, metabolic parameters, and fatigue in obese subjects: a double-blind randomized controlled study The effects of coenzyme Q10 supplementation on performance during repeated bouts of supramaximal exercise in sedentary men Antifatigue effects of coenzyme Q10 during physical fatigue CancerCoenzyme Q10 for Prevention of Anthracycline-Induced Cardiotoxicity - Kenneth A. Conklin, 2005 Apparent partial remission of breast cancer in ‘High Risk' patients supplemented with nutritional antioxidants, essential fatty acids and Coenzyme Q10 Partial and Complete Regression of Breast Cancer in Patients in Relation to Dosage of Coenzyme Q10 Coenzyme Q10 (PDQ®) - PDQ Cancer Information Summaries - NCBI Bookshelf FibromyalgiaOxidative stress correlates with headache symptoms in fibromyalgia: coenzyme Q₁₀ effect on clinical improvement Oral coenzyme Q10 supplementation improves clinical symptoms and recovers pathologic alterations in blood mononuclear cells in a fibromyalgia patient Coenzyme Q(10): a novel therapeutic approach for Fibromyalgia? case series with 5 patients Can coenzyme q10 improve clinical and molecular parameters in fibromyalgia? Increased oxidative stress and coenzyme Q10 deficiency in juvenile fibromyalgia: amelioration of hypercholesterolemia and fatigue by ubiquinol-10 supplementation MyocarditisExclusive: Athlete Who Recovered From COVID Facing 'Very Different Future' After Second Dose of Pfizer Vaccine Triggers Myocarditis • Children's Health Defense CDC Advisory Committee Will Meet to Discuss Reports of Myocarditis in Young People After COVID Vaccines • Children's Health Defense The protection of coenzyme Q10 against experimental viral myocarditis in mice Antioxidant effects of coenzyme Q10 on experimental viral myocarditis in mice Why You Need to Eat More Organs!Chicken Heart Skewers Peanut Butter Liver Pate Mini Meatloaf Muffins w/ Bacon & Caramelized Onions Organ meatballs (coming soon on youtube, subscribe to be alerted when it comes out!)   Sponsors for this episode:    This episode is sponsored by the Naturally Nourished supplement line: these pure, potent and effective formulas have been hand selected to deliver profound health benefits. We price our formulas 2-5% below market industry standard and competitors and guarantee that our products will always be third party assessed to ensure they are free of mold, toxins, contaminants, and contain the stated active ingredients in dosages noted.  Use code COQ10PODCAST for 15% off your first bottle of CoQ10 Complex!    This episode is also sponsored by FOND Bone Broth Tonics, Your Sous Chef in a Jar. FOND is slow simmered and lovingly tended from simmer to seal. They partner with organic farms and hand-pick and pair ingredients to optimize absorption and taste. Use code ALIMILLERRD to save at fondbonebroth.com.

Clinical Significance of Micronutrient Supplementation in Critically Ill COVID-19 Patients with Severe ARDS  University Hospital Wuerzburg (Germany), June 12, 2021 Abstract The interplay between inflammation and oxidative stress is a vicious circle, potentially resulting in organ damage. Essential micronutrients such as selenium (Se) and zinc (Zn) support anti-oxidative defense systems and are commonly depleted in severe disease. This single-center retrospective study investigated micronutrient levels under Se and Zn supplementation in critically ill patients with COVID-19 induced acute respiratory distress syndrome (ARDS) and explored potential relationships with immunological and clinical parameters. According to intensive care unit (ICU) standard operating procedures, patients received 1.0 mg of intravenous Se daily on top of artificial nutrition, which contained various amounts of Se and Zn. Micronutrients, inflammatory cytokines, lymphocyte subsets and clinical data were extracted from the patient data management system on admission and after 10 to 14 days of treatment. Forty-six patients were screened for eligibility and 22 patients were included in the study. Twenty-one patients (95%) suffered from severe ARDS and 14 patients (64%) survived to ICU discharge. On admission, the majority of patients had low Se status biomarkers and Zn levels, along with elevated inflammatory parameters. Se supplementation significantly elevated Se (p = 0.027) and selenoprotein P levels (SELENOP; p = 0.016) to normal range. Accordingly, glutathione peroxidase 3 (GPx3) activity increased over time (p = 0.021). Se biomarkers, most notably SELENOP, were inversely correlated with CRP (rs = −0.495), PCT (rs = −0.413), IL-6 (rs = −0.429), IL-1β (rs = −0.440) and IL-10 (rs = −0.461). Positive associations were found for CD8+ T cells (rs = 0.636), NK cells (rs = 0.772), total IgG (rs = 0.493) and PaO2/FiO2ratios (rs = 0.504). In addition, survivors tended to have higher Se levels after 10 to 14 days compared to non-survivors (p = 0.075). Sufficient Se and Zn levels may potentially be of clinical significance for an adequate immune response in critically ill patients with severe COVID-19 ARDS.       Pilot Study of the Tart Cherry Juice for the Treatment of Insomnia and Investigation of Mechanisms Louisiana State University, June 20, 2021 Insomnia is common in the elderly and is associated with chronic disease, but use of hypnotics increases the incidence of falls. Montmorency tart cherry juice has improved insomnia by self-report questionnaire. Study Question:  Is insomnia confirmed by polysomnography and is tryptophan availability a potential mechanism for treating insomnia? Study Design:  A placebo-controlled balanced crossover study with subjects older than 50 years and insomnia were randomized to placebo (2 weeks) or cherry juice (2 weeks) (240 mL 2 times/d) separated by a 2-week washout. Measures and Outcomes:  Sleep was evaluated by polysomnography and 5 validated questionnaires. Serum indoleamine 2,3-dioxygenase (IDO), the kynurenine-to-tryptophan ratio, and prostaglandin E2 were measured. In vitro, Caco-2 cells were stimulated with interferon-gamma, and the ability of cherry juice procyanidin to inhibit IDO which degrades tryptophan and stimulates inflammation was measured. The content of procyanidin B-2 and other major anthocyanins in cherry juice were determined. Results:  Eleven subjects were randomized; 3 with sleep apnea were excluded and referred. The 8 completers with insomnia increased sleep time by 84 minutes on polysomnography (P = 0.0182) and sleep efficiency increased on the Pittsburgh Sleep Quality Index (P = 0.03). Other questionnaires showed no significant differences. The serum kynurenine-to-tryptophan ratio decreased, as did the level of prostaglandin E2 (both P < 0.05). In vitro, cherry juice procyanidin B-2 dose-dependently inhibited IDO. Conclusions:  Cherry juice increased sleep time and sleep efficiency. Cherry juice procyanidin B-2 inhibited IDO, increased tryptophan availability, reduced inflammation, and may be partially responsible for improvement in insomnia.         Many with migraines have vitamin deficiencies, says study   Cincinnati Children's Hospital, June 10, 2021    A high percentage of children, teens and young adults with migraines appear to have mild deficiencies in vitamin D, riboflavin and coenzyme Q10—a vitamin-like substance found in every cell of the body that is used to produce energy for cell growth and maintenance.   These deficiencies may be involved in patients who experience migraines, but that is unclear based on existing studies.   "Further studies are needed to elucidate whether vitamin supplementation is effective in migraine patients in general, and whether patients with mild deficiency are more likely to benefit from supplementation," says Suzanne Hagler, MD, a Headache Medicine fellow in the division of Neurology at Cincinnati Children's Hospital Medical Center and lead author of the study.   Dr. Hagler and colleagues at Cincinnati Children's conducted the study among patients at the Cincinnati Children's Headache Center. She will present her findings at 9:55 am Pacific time Friday, June 10, 2016 at the 58th Annual Scientific Meeting of the American Headache Society in San Diego.   Dr. Hagler's study drew from a database that included patients with migraines who, according to Headache Center practice, had baseline blood levels checked for vitamin D, riboflavin, coenzyme Q10 and folate, all of which were implicated in migraines, to some degree, by previous and sometimes conflicting studies. Many were put on preventive migraine medications and received vitamin supplementation, if levels were low. Because few received vitamins alone, the researchers were unable to determine vitamin effectiveness in preventing migraines.   She found that girls and young woman were more likely than boys and young men to have coenzyme Q10 deficiencies at baseline. Boys and young men were more likely to have vitamin D deficiency. It was unclear whether there were folate deficiencies. Patients with chronic migraines were more likely to have coenzyme Q10 and riboflavin deficiencies than those with episodic migraines.   Previous studies have indicated that certain vitamins and vitamin deficiencies may be important in the migraine process. Studies using vitamins to prevent migraines, however, have had conflicting success.     Research suggests mask-wearing can increase struggles with social anxiety University of Waterloo (Canada), June 21, 2021 People who struggle with social anxiety might experience increased distress related to mask-wearing during and even after the COVID-19 pandemic. A paper authored by researchers from the University of Waterloo's Department of Psychology and Centre for Mental Health Research and Treatment also has implications for those who haven't necessarily suffered from social anxiety in the past. "The adverse effects of the COVID-19 pandemic on mental health outcomes, including anxiety and depression, have been well-documented," said David Moscovitch, professor of clinical psychology and co-author of the paper. "However, little is known about effects of increased mask-wearing on social interactions, social anxiety, or overall mental health. "It is also possible that many people who didn't struggle with social anxiety before the pandemic may find themselves feeling more anxious than usual as we emerge out of the pandemic and into a more uncertain future -- especially within social situations where our social skills are rusty and the new rules for social engagement are yet to be written." Social anxiety is characterized by negative self-perception and fear that one's appearance or behaviour will fail to conform with social expectations and norms. Social anxiety disorder is an extreme manifestation that affects up to 13 per cent of the population.  The researchers reviewed existing literature addressing three factors that they hypothesized might contribute to social anxiety associated with mask-wearing: hypersensitivity to social norms, bias in the detection of social and emotional facial cues, and propensity for self-concealment as a form of safety behaviour. "We found that mask-wearing by people with social anxiety is likely to be influenced by their perception of social norms and expectations, which may or may not be consistent with public-health guidelines and can vary widely by region and context," said Sidney Saint, an undergraduate psychology student at Waterloo and lead author of the paper. The paper also highlights that people with social anxiety have difficulty detecting ambiguous social cues and are likely to interpret them negatively. These individuals also tend to worry about sounding incomprehensible or awkward. "We believe that both issues are likely to be magnified during interactions with masks," Saint said. Another highlighted impact is that masks can function as a type of self-concealment strategy that enables people with social anxiety to hide their self-perceived flaws. Therefore, the desire for self-concealment may motivate their use of masks over and above their desire to protect themselves from contagion. "Due to their self-concealing function, masks may be difficult for some people to discard even when mask-wearing is no longer required by public health mandates," Saint said.  In addition to contributing insights to guide clinicians toward effective assessment and treatment, the paper shows that people with social anxiety may be particularly vulnerable to periods of norm transitions where expectations for mask-wearing are in flux or become a matter of personal choice.       Going with your gut can result in better decision-making than using detailed data methods, study shows City University London, June 21, 2021 Managers who use their gut instinct together with simple decision-making strategies may make equally good, but faster, decisions as those who use data to reach an outcome, a new study has found. The report, co-authored by academics at the Business School (formerly Cass), King's Business School, and the University of Malta, finds that the reliance on data analysis in decision-making might be counterproductive as this reduces decision-making speed without ensuring more accuracy. The research, based on information from 122 advertising, digital, publishing, and software companies, finds that using data to inform decision making under high uncertainty is often not optimal. This may explain why 12 different publishers initially rejected the opportunity to publish "Harry Potter and the Philosopher's Stone' – because it had no data to inform its potential. A recent survey revealed that 92 percent of Fortune 1000 companies were reporting increased investment in data initiatives, although it appears this may not always be necessary. The authors asked managers how they made decisions on their most recent innovation project, including the extent to which they used data, instinct, and other simple heuristics (mental strategies). The findings outlined that among those decision-making methods were: Majority—choosing what the most people wanted Tallying—picking the choice with the greatest quantity of positive points Experience—selecting the option that the most experienced individual on the team wanted. Managers were asked whether they think they made the right decision and how fast they were in reaching that decision. Results showed that managers relied on their own instinct as much as data, using 'tallying' more than any other metric. Dr. Oguz A. Acar, Reader in Marketing at the Business School and co-author of the report, said: "This research shows that data-driven decision-making is not the panacea in all situations and may not result in increased accuracy when facing uncertainty. "Under extreme uncertainty, managers, particularly those with more experience, should trust the expertise and instincts that have propelled them to such a position. The nous developed over years as a leader can be a more effective than an analytical tool which, in situations of extreme uncertainty, could act as a hindrance rather than a driver of success." "Choosing among alternative new product development projects: The role of heuristics" is published in Psychology and Marketing.   Pretreatment by rosemary extract or cell transplantation improves memory deficits of Parkinson disease Damghan University (Iran) June 21 2021 According to news originating from Damghan, Iran, research stated, “The therapeutic effect of adipose tissue-derived stem cells (ADSCs) or RE on hippocampal neurogenesis and memory in Parkinsonian rats were investigated. Male rats were lesioned by bilateral intra-nigral injections of 6-OHDA and divided into six groups: 1. Lesion 2 and 3: RE and water groups were lesioned rats pretreated with RE or water, from 2weeks before neurotoxin injection and treated once a day for 8weeks post lesion. 4&5: Cell and alpha-MEM (alpha-minimal essential medium) received intravenous injection of BrdU-labeled ADSCs or medium, respectively from 10days post lesion until 8weeks later. 6: Sham was injected by saline instead of neurotoxin.” Our news journalists obtained a quote from the research from Damghan University, “Memory was assessed using Morris water Maze (MWM), one week before and at 1, 4 and 8weeks post 6-OHDA lesion. After the last probe, the animals were sacrificed and brain tissue obtained. Paraffin sections were stained using cresyl violet, anti-BrdU (Bromodeoxyuridine / 5-bromo-2'-deoxyuridine), anti-GFAP (Glial fibrillary acidic protein) and anti-TH antibodies. There was a significant difference of time spent in the target quadrant between groups during probe trial at 4 and 8 weeks' post-lesion. Cell and RE groups spent a significantly longer period in the target quadrant and had lower latency as compared with lesion. Treated groups have a significantly higher neuronal density in hippocampus compared to water, alpha-MEM and lesion groups. BrdU positive cells were presented in lesioned sites. The GFAP (Glial fibrillary acidic protein) positive cells were reduced in treated and sham groups compared to the water, alpha-MEM and lesion groups.” According to the news editors, the research concluded: “Oral administration of RE (Rosemary extract) or ADSCs injection could improve memory deficit in the Parkinsonian rat by neuroprotection.”     Inadequate vitamin D levels associated with interstitial lung disease Johns Hopkins University, June 20 2021.    An article appearing in the Journal of Nutrition documents a link between decreased vitamin D levels and a greater risk of early signs of interstitial lung disease (ILD), a group of disorders characterized by inflammation and scarring that can lead to lung damage. Although ILD can be caused by environmental and other factors, some cases have unknown causes. The investigation included 6,302 participants in the Multi-Ethnic Study of Atherosclerosis who had information available concerning their initial serum 25-hydroxyvitamin D concentrations and computed tomography (CT) imaging that included partial views of the lungs. Ten years after enrollment, 2,668 participants had full lung CT scans that were evaluated for presence of scar tissue and other abnormalities. Subjects who had deficient vitamin D levels of less than 20 ng/mL had more spots on their lungs that were suggestive of damage in comparison with subjects whose vitamin D was adequate. Among those who had full lung CT scans, deficient or intermediate (between 20-30 ng/mL) vitamin D levels were associated with a 50-60% greater risk of abnormalities suggestive of ILD. "We knew that the activated vitamin D hormone has anti-inflammatory properties and helps regulate the immune system, which goes awry in ILD," commented senior author Erin Michos, MD, MHS. “There was also evidence in the literature that vitamin D plays a role in obstructive lung diseases such as asthma and COPD, and we now found that the association exists with this scarring form of lung disease too." "Our study suggests that adequate levels of vitamin D may be important for lung health,” she concluded. “We might now consider adding vitamin D deficiency to the list of factors involved in disease processes, along with the known ILD risk factors such as environmental toxins and smoking.”

VIDEOS   1. Sen. Johnson and Dr. Pierre Kory on the impact of censorship in fight against COVID-19   2. New Rule: Getting It in the Nuts | Real Time with Bill Maher (HBO)   3.  Black father destroys critical race theory at school board meeting   4.  Wuhan 15,00 bat samples and their virus databases all wiped from the internet   5. Fauci, Gain-of-Function Research, and Wuhan Lab Funding. Joe Rogan with Krystal Ball & Saagar Enjeti   Krystal Ball and Sagaar Enjeti are political commentators and hosts of the YouTube show and podcast "Breaking Points".   CoQ10 supplementation associated with lower pro-inflammatory factors in randomized trial Shahid Sadoughi University of Medical Sciences (Iran), June 8 2021    A double-blind trial reported in the International Journal of Vitamin and Nutrition Research found a reduction in markers ofinflammation in mildly hypertensive patients given coenzyme Q10 (CoQ10) for twelve weeks. Participants who received CoQ10 also experienced an increase in adiponectin: a protein secreted by adipose tissue that has an anti-inflammatory effect and which has been found to be reduced in high blood pressure and cardiovascular disease.   "Considering that coenzyme Q10 has attracted noticeable attention in recent years for the treatment of cardiovascular diseases and hypertension in regard to its effect on inflammatory factors such as cytokines, it is therefore hypothesized that supplementation with coenzyme Q10 reduces the proinflammatory factors," write Nasim Bagheri Nesami of Iran's Shahid Sadoughi University of Medical Sciences and colleagues. "This study was conducted in order to determine the effects of coenzyme Q10 on proinflammatory factors as well as on adiponectin in patients with mild hypertension." Sixty men and women were randomized to receive 100 milligrams CoQ10 or a placebo for a twelve week period. Plasma adiponectin, high-sensitivity C-reactive protein (hs-CRP, a marker of inflammation) and the cytokines interleukin 2, interleukin 6 and tumor necrosis factor-alpha were measured before and after treatment. At the end of the study, participants who received CoQ10 had significant declines in interleukin-6 and hs-CRP compared with levels measured upon enrollment. They also experienced an increase in adiponectin, while levels in the placebo group slightly declined. The authors suggest that CoQ10 could be prescribed as a supplement along with antihypertensive medication for patients with mildly elevated blood pressure, and recommend that further research be conducted to validate the current findings.     Exposure to nature during COVID-19 lockdown was beneficial for mental health A study by the ICTA-UAB and the University of Porto analyses the effects of exposure to green spaces during the first months of the COVID19 pandemic in Spain and Portugal Universitat Autònoma of Barcelona (Spain), June 18, 2021 A study carried out by the Institute of Environmental Science and Technology of the Universitat Autònoma de Barcelona (ICTA-UAB) and the Instituto de Saúde Pública of the University of Porto (ISPUP), concludes that exposure to natural spaces during the first COVID-19 lockdown in 2020 was beneficial for the mental health of Spanish and Portuguese citizens. The research shows that, in Portugal, during the first confinement, people who maintained or increased contact with natural public spaces, such as parks and coastal areas, or who could contemplate these spaces from their homes, presented lower levels of stress, psychological distress and psychosomatic symptoms. In Spain, those who maintained or increased contact with private natural spaces, such as indoor plants or community green areas, presented lower levels of stress and psychosomatic symptoms. This could be due to the fact that Spain adopted more restrictive measures for foreign circulation during the period analysed. The research Exposure to nature and mental health outcomes during COVID-19 lockdown. A comparison between Portugal and Spain, published in the journal Environment International, was conducted between March and May 2020. Dr Ana Isabel Ribeiro, researcher at the ISPUP and first author of the work together with Margarita Triguero-Mas from the ICTA-UAB says that "we decided to study whether natural, public and private spaces had a beneficial effect on the mental health of Portuguese and Spanish citizens, helping them to better cope with the negative effects of lockdown". For her part, Margarita Triguero-Mas adds that "people around us and ourselves talked about how we missed the park we crossed when we went to the office or the walk on the beach with our dogs, so we wanted to check to what extent contact with natural spaces was an important factor during confinement". Several previous articles have also shown the positive impact of exposure to natural spaces on mental health, that is, in reducing stress, anxiety and improving psychological well-being as a whole. "Taking into account what is described in the literature, we wanted to evaluate whether people who enjoyed greater exposure to natural spaces during the first COVID-19 lockdown had better mental health indicators than those who had no contact with natural areas", explains Dr Ribeiro. At the same time, they wanted to investigate whether exposure to private natural spaces, such as gardens, orchards or plants, was more beneficial among Spanish citizens than among Portuguese, given that Spain applied stricter measures to restrict mobility than Portugal. To carry out the research, the authors applied an online questionnaire, between March 27 and May 6, 2020, aimed at all citizens aged 18 years old or older, residing in Spain or Portugal. The survey covered aspects related to the frequency and type of exposure people had to natural spaces (public and private), before and during the first confinement; mental health questions to assess levels of stress, mental disorders and somatization symptoms, and sociodemographic issues. Of the more than 3,000 citizens (n = 3,157) who answered the questionnaire, 1,638 were Portuguese and 1,519 Spanish. In both countries, during the confinement, there was a significant reduction in the use of public natural spaces, such as beaches, parks and gardens, and an increase in contact with private natural spaces, such as community gardens, urban gardens and plants, especially in Spain. People living in single-family houses (detached house) and flats located in cities were the ones who least maintained or increased their exposure to public natural spaces in both countries. In Spain, where the measures during the period analysed were much more restrictive and it was forbidden to leave the house and public outdoor spaces were closed, the benefits of exposure to public natural spaces were not as relevant as in Portugal, but it was clear the importance of private natural elements. Among the Spanish citizens who participated in the study, 66% decreased the frequency of exposure to public natural spaces (compared to 54% in Portugal). In Spain, people who had the opportunity to continue dedicating or increasing the time dedicated to caring for their plants had lower stress levels, while those who were able to continue enjoying or increasing the time of use of community green spaces had lower rates of somatization.  In Spain, it is remarkable that the people who least maintained or increased the care of indoor plants were people over 65 years of age, those who lived with several people at home or those who were in a second residence during confinement. In contrast, the people who maintained or increased the care of indoor plants the most were those with children, but without dependent adults. In Portugal, those who were confined the longest and those who commuted to work were those who least maintained or increased their contact with the natural public spaces. In turn, those who practiced physical exercise indicated greater exposure to these places. Portuguese citizens who managed to maintain or increase their exposure to natural public spaces showed lower levels of stress compared to those who did not. Likewise, those who contemplated natural spaces from their homes obtained improvements in all the mental health outcomes analysed: stress, mental disorders and somatization. "This study clearly demonstrates the benefit of natural spaces for the mental health of the population in a context of public health crisis," says Ana Isabel Ribeiro. "Public authorities and decision-makers could implement measures that facilitate access to natural public spaces, in a safe and controlled manner, in the context of a pandemic. This is particularly important for the most socially and economically vulnerable population groups, and for those who have little access to these spaces in their private context", she emphasizes. In addition, Dr Triguero-Mas adds that "our study is especially important for cities like Barcelona, where new buildings rarely have balconies or community spaces with vegetation. It is important to revalue how building remodelling or new homes can be healthier spaces that promote and prevent deterioration in the health of the people who inhabit them". Flame retardants and pesticides overtake heavy metals as biggest contributors to IQ loss New York University, June 2, 2021   Adverse outcomes from childhood exposures to lead and mercury are on the decline in the United States, likely due to decades of restrictions on the use of heavy metals, a new study finds. Despite decreasing levels, exposure to these and other toxic chemicals, especially flame retardants and pesticides, still resulted in more than a million cases of intellectual disability in the United States between 2001 and 2016. Furthermore, as the target of significantly fewer restrictions, experts say, flame retardants and pesticides now represent the bulk of that cognitive loss. NYU Grossman School of Medicine researchers found that IQ loss from the toxic chemicals analyzed in their study dropped from 27 million IQ points in 2001 and 2002 to 9 million IQ points in 2015 and 2016. While this overall decline is promising, the researchers say, their findings also identify a concerning shift in which chemicals represent the greatest risk. Among toxin-exposed children, the researchers found that the proportion of cognitive loss that results from exposure to chemicals used in flame retardants, called polybrominated diphenyl ethers (PDBEs), and organophosphate pesticides increased from 67 percent to 81 percent during the same study period. "Our findings suggest that our efforts to reduce exposure to heavy metals are paying off, but that toxic exposures in general continue to represent a formidable risk to Americans' physical, mental, and economic health," says lead study investigator Abigail Gaylord, MPH, a doctoral candidate in the Department of Population Health at NYU Langone. "Unfortunately, the minimal policies in place to eliminate pesticides and flame retardants are clearly not enough." The substances analyzed are found in household products from furniture upholstery to tuna fish, and can build up in the body to damage organs, researchers say. Heavy metals, lead and mercury in particular, are known to disrupt brain and kidney function. In addition, they, along with flame retardants and pesticides, can interfere with the thyroid, which secretes brain-developing hormones. Experts say exposure at a young age to any of these toxins can cause learning disabilities, autism, and behavioral issues. In their investigation, the researchers found that everyday contact with these substances during the 16-year study period resulted in roughly 1,190,230 children affected with some form of intellectual disability. Overall childhood exposures cost the nation $7.5 trillion in lost economic productivity and other societal costs. "Although people argue against costly regulations, unrestricted use of these chemicals is far more expensive in the long run, with American children bearing the largest burden," says senior study author Leonardo Trasande, MD, MPP, the Jim G. Hendrick, MD Professor at NYU Langone Health. Publishing online Jan. 14 in the journal Molecular and Cellular Endocrinology, the new study is the only long-term neurological and economic investigation of its kind, the authors say. The investigators analyzed PBDE, organophosphate, lead, and methylmercury exposures in blood samples from women of childbearing age and 5-year-olds. Data on women and children was obtained from the National Health and Nutrition Examination Survey. The researchers used results from several previous environmental health studies to estimate the annual number of IQ points lost per unit of exposure to each of the four main chemicals in the study. Then, they estimated the lost productivity and medical costs over the course of the children's lives linked to long-term intellectual disability using a second algorithm, which valued each lost IQ point at $22,268 and each case of intellectual disability at $1,272,470. While exposure to these chemicals persists despite tightened regulations, experts say Americans can help limit some of the effects by avoiding the use of household products or foods that contain them. "Frequently opening windows to let persistent chemicals found in furniture, electronics, and carpeting escape, and eating certified organic produce can reduce exposure to these toxins," says Trasande, who also serves as chief of environmental pediatrics in the Department of Pediatrics at NYU Langone. Trasande notes that the impact of these chemicals may be worse than their study can capture since there are far more hazards that affect brain development than the four highlighted in the investigation, and other potential consequences beyond IQ loss. "All the more reason we need closer federal monitoring of these substances," she says. The study authors say they plan to explore the cost of exposure to endocrine-disrupting chemicals in other countries. Red meat consumption may promote DNA damage-assoc. mutation in colorectal cancer patients Study provides mechanistic link between red meat consumption and colorectal cancer development Harvard Medical School, June 17, 2021 Bottom Line: Genetic mutations indicative of DNA damage were associated with high red meat consumption and increased cancer-related mortality in patients with colorectal cancer. Journal in Which the Study was Published: Cancer Discovery, a journal of the American Association for Cancer Research Author: Marios Giannakis, MD, PhD, an assistant professor of medicine at Harvard Medical School and a physician at Dana-Farber Cancer Institute Background: "We have known for some time that consumption of processed meat and red meat is a risk factor for colorectal cancer," said Giannakis. The International Agency for Research on Cancer declared that processed meat was carcinogenic and that red meat was probably carcinogenic to humans in 2015.  Experiments in preclinical models have suggested that red meat consumption may promote the formation of carcinogenic compounds in the colon, but a direct molecular link to colorectal cancer development in patients has not been shown, Giannakis explained. "What is missing is a demonstration that colorectal cancers from patients have a specific pattern of mutations that can be attributed to red meat," he said. "Identifying these molecular changes in colon cells that can cause cancer would not only support the role of red meat in colorectal cancer development but would also provide novel avenues for cancer prevention and treatment." How the Study was Conducted: To identify genetic changes associated with red meat intake, Giannakis and colleagues sequenced DNA from matched normal and colorectal tumor tissues from 900 patients with colorectal cancer who had participated in one of three nationwide prospective cohort studies, namely the Nurses' Health Studies and the Health Professionals Follow-Up Study. All patients had previously provided information on their diets, lifestyles, and other factors over the course of several years prior to their colorectal cancer diagnoses.  Results: Analysis of DNA sequencing data revealed the presence of several mutational signatures in normal and cancerous colon tissue, including a signature indicative of alkylation, a form of DNA damage. The alkylating signature was significantly associated with pre-diagnosis intake of processed or unprocessed red meat, but not with pre-diagnosis intake of poultry or fish or with other lifestyle factors. Red meat consumption was not associated with any of the other mutational signatures identified in this study. In line with prior studies linking red meat consumption with cancer incidence in the distal colon, Giannakis and colleagues found that normal and cancerous tissue from the distal colon had significantly higher alkylating damage than tissue from the proximal colon.  Using a predictive model, the researchers identified the KRAS and PIK3CA genes as potential targets of alkylation-induced mutation. Consistent with this prediction, they found that colorectal tumors harboring KRAS G12D, KRAS G13D, or PIK3CA E545K driver mutations, which are commonly observed in colorectal cancer, had greater enrichment of the alkylating signature compared to tumors without these mutations. The alkylating signature was also associated with patient survival: Patients whose tumors had the highest levels of alkylating damage had a 47 percent greater risk of colorectal cancer-specific death compared to patients with lower levels of damage. Author's Comments: "Our study identified for the first time an alkylating mutational signature in colon cells and linked it to red meat consumption and cancer driver mutations," said Giannakis. "These findings suggest that red meat consumption may cause alkylating damage that leads to cancer-causing mutations in KRAS and PIK3CA, thereby promoting colorectal cancer development. Our data further support red meat intake as a risk factor for colorectal cancer and also provide opportunities to prevent, detect, and treat this disease."  Giannakis explained that if physicians could identify individuals who are genetically predisposed to accumulating alkylating damage, these individuals could be counseled to limit red meat intake as a form of precision prevention. In addition, the alkylating mutational signature could be used as a biomarker to identify patients at greater risk of developing colorectal cancer or to detect cancer at an early stage. Because of its association with patient survival, the alkylating signature may also have potential as a prognostic biomarker. However, future studies are needed to explore these possibilities, Giannakis noted. Study Limitations: A limitation of the study is the potential selection bias of study participants, as tissue specimens could not be retrieved from all incident colorectal cancer cases in the cohort studies. Current studies from Giannakis and his colleagues are exploring the potential role of red meat intake and alkylating damage in diverse groups of patients. Funding & Disclosures: The study was supported by the National Institutes of Health, the Stand Up To Cancer Colorectal Cancer Dream Team Translational Research Grant (co-administered by the AACR), the Project P Fund, the Cancer Research UK Grand Challenge Award, the Nodal Award from the Dana-Farber Harvard Cancer Center, the Friends of the Dana-Farber Cancer Institute, the Bennett Family Fund, and the Entertainment Industry Foundation through the National Colorectal Cancer Research Alliance and Stand Up To Cancer.  Giannakis has received research funding from Bristol-Myers Squibb, Merck, Servier, and Janssen unrelated to this study. Association of higher average daily polyphenol intake with Mediterranean diet adherence and decreased waist to hip circumference University of the Aegean (Greece), June 14, 2021 According to news reporting originating from the University of the Aegean research stated, “Research data indicate the possible effect of both polyphenols consumption and Mediterranean diet adherence on metabolic diseases' prevalence. The present retrospective study investigated the possible association of polyphenols mean daily intake with Mediterranean diet adherence and anthropometric indices in a sample of the Greek population.” Our news reporters obtained a quote from the research from University of the Aegean: “A total of 250 healthy volunteers, aged between 18 and 65 years, were randomly recruited from central and northern Greece. Total daily polyphenols intake was estimated using a semi-quantitative food frequency questionnaire (FFQ) based on the NHANES study, while Med Diet Score was used for the degree of Mediterranean diet adoption. Daily polyphenols intake was identified by the Phenol Explorer database, and anthropometric measurements (BMI, waist-to-hip circumference, and body composition) were performed. The mean daily polyphenols intake was determined to be 1905 mg, while most of the participants had moderate or high mean consumption last year (67.5% of the sample were consuming more than 1000 mg/d). Moderate adherence to the Mediterranean diet (higher Med Diet Score) was associated with increased mean daily polyphenols intake (* * p* * = 0.016). Increased polyphenols intake and higher Med Diet Score were associated with decreased waist-to-hip circumference (* * p* * = 0.027, 0.004, respectively).” According to the news editors, the research concluded: “Specific functional foods rich in polyphenols, such as sour cherry, tomatoes, black tea, and cocoa were associated with improved body composition indices. Larger epidemiological studies need to be performed for safer conclusions about whole population polyphenols intake and its association with metabolic disease biomarkers.” Whole, natural fiber works best to protect gut mucosal layer, researcher says University of Michigan, June 12, 2021 Dietary fiber plays an important role in protecting the gut's mucosal layer, according to research presented at the recent Probiota Americas event. It has long been known that the gut stays healthier and performs better with adequate fiber. But why? This is one of the questions that informed the research conducted by Dr Eric Martens, assistant professor of microbiology and immunology at the University of Michigan. Martens presented his research at the  IPA World Congress + Probiota Americas event, which was hosted by William Reed in Chicago last week. The event brought together 280 regulators, probiotics and prebiotics researchers and product developers.  Protecting the mucosal layer Martens said that his research showed that without adequate fiber in the gut, some organisms that might be nourished by that food source will look to alternative sources, one of which is the gut's mucosal layer. That layer is a critical component of the gut wall, and when it is eroded or absent harmful bacteria have an opportunity to latch onto the cells of the wall itself. “The core of our research is we are interested in the physiology of the many bacteria that live in the gut and defining at the functional and mechanistic level how they work with goal of understanding how the community works,” Martens said. The study he presented used 14 different bacteria with defined characteristics in a mouse model. The study had three groups, a group fed a fiber free diet, one with a whole grain diet rich in natural fibers, and a third that had fiber added back in in the form of purified, prebiotic fibers.  His research found that the whole grain, natural fibers fostered a microbial community in which the muscosa-eroding organisms were suppressed the best. He postulated that this could be because the large, whole food particles typical of the natural fiber diet were best able to reach the distal regions of the gut and affect the microbial community makeup there, whereas the purified fibers may have been mostly digested by that point. What Is the Liver Powerhouse Silymarin? GreenMedInfo  June 17th 2021   Here's what science has found most beneficial about silymarin, extracted from milk thistle and known to be a friend of your liver mainly through its antioxidant and anti-inflammatory properties When it comes to treating liver and gallbladder disorders, there is one name that stands out: silymarin. As a group of flavonolignans extracted from milk thistle, silymarin has been traditionally used for various protective benefits, from reinvigorating liver function to promoting breast milk production. The milk thistle plant, scientifically known as Silybum marianum, is a prickly plant with purple flowers and milky white veins present on the leaves, thus its name. Silymarin is the group of plant compounds that act as its active ingredient.[i] Silymarin is the main bioactive component of this medicinal plant. It is a mix of various flavonolignans, includings silybinin A and B, isosilybinin A and B, silychristin and silydianin.[ii] Milk thistle extract has a high silymarin content of approximately 65% to 80%. Silymarin is famed for its antioxidant, antiviral and anti-inflammatory components,[iii] as well as its traditional use or treating the liver and restoring its health. In addition, milk thistle itself is generally considered safe to take. Side effects are rare, and in an oral form standardized to contain 70% to 80% silymarin, it appears to be safe for up to 41 months of use.[iv] Silymarin's Liver-Protective Effects Fights liver inflammation and liver damage. Mounting evidence shows improvements in liver function among people with liver diseases who have taken a milk thistle supplement.[v] This suggests protection against flavanone silibinin liver inflammation and liver damage through use of the natural -- silymarin's primary active component -- which was combined with phosphatidylcholine in a specific study to enhance its solubility and bioavailability. Protects from toxins such as amatoxin, produced by Amanita mushroom, which can cause death if ingested. Two cases in the U.S. were treated with N-acetylcysteine, high-dose penicillin, cimetidine and silibinin.[vi] Uncontrolled trials and case reports cited successful treatment with intravenous silibinin, a flavonolignan isolated from milk thistle extracts, in nearly 1,500 cases.[vii] Overall mortality in those treated with the formula was less than 10%, compared to more than 20%when using penicillin, or a mix of silibinin and penicillin. Reduces liver fibrosis. In a randomized trial of 99 patients, the team administered silymarin in 700-milligram (mg) doses, or a placebo, given three times daily for 48 weeks.[viii] Non-alcoholic fatty liver disease (NAFLD) activity score was reduced by 32.7% in the silymarin group compared to 26% in the placebo group. Among the secondary outcomes were reductions in inflammation and fibrosis score in the silymarin group, leading the researchers to conclude that silymarin may decrease liver fibrosis, to be confirmed in larger trials. Fibrosis is the formation of abnormally large amounts of scar tissue in the liver. Helps prevent liver cancer. Studies have concluded that the long-term use of silymarin significantly increases survival time among patients with alcohol-induced liver cirrhosis, a risk factor for liver cancer. Silymarin can also significantly reduce tumor cell proliferation, angiogenesis or new blood vessel formation, as well as insulin resistance.[ix] The chemopreventive effects "have been established in several studies using in vitro and in vivo methods," according to the researchers, and combine well with anti-inflammatory and inhibitory effects on the metastasis or spread of cancer. Contributes to liver regeneration. An animal study suggested that silymarin played a crucial role in accelerating liver regeneration after liver resection, a kind of surgery designed to remove cancerous tumors from the liver.[x] Liver regeneration is thought to evolve to protect animals from loss of liver due to toxins or tissue injury. Silymarin for Breastfeeding, Neurological Support Not to be ignored is silymarin's formidable list of other health benefits, such as boosting milk production in lactating mothers. A randomized trial found that mothers taking 420 mg of silymarin for 63 days produced more breast milk than subjects who took a placebo.[xi] Silymarin combined with phosphatidylserine and galega also increased milk production in moms of preterm infants, without any significant side effects.[xii] Milk thistle is also a traditional remedy for neurological disorders such as Alzheimer'sand Parkinson's diseases. Its antioxidant and anti-inflammatory action mean it may be neuroprotective and help prevent the brain decline experienced with aging.

继上一次的听众问问答2.0已经过去好几个月啦！所以我们又回来了，拖了这么久的听众问问答3.0上线！！这一期你将会听到……01：40 当红主播男友亚当来袭02：08 欢迎亚当，卡门对亚当专访02：29 亚当跟桃乐丝在一起快两年，XSH到底是什么情况？03：10 徐熙娣来家里做客，大长水疗器具在厕所里？04：45 徐熙娣独自逗留亚当家到深夜？05：18 桃乐丝做播客以后，跟亚当的生活发生了什么变化？06：41 亚当控诉，桃乐丝剪节目时间太长，工作跟生活分不开08：11 卡门是影响桃乐丝和亚当感情的主要原因？10：32 卡门对亚当的初印象10：50 桃乐丝明令禁止亚当喝大酒，原因居然是？12：08 亚当笑道桃乐丝喝完酒以后的囧态13：58 亚当喜欢皮鞭？？14：42 桃乐丝不介意徐熙娣做小的？14：58 正片开始！！听众问问答3.0来了！15：17 Q1——怎么跟父母去谈XING？16：50 父母睡觉关房门吗？18：21 卡门开飞机被妈妈撞见19：43 卡门妈妈担心卡门跟女孩在玩到太晚20：36 卡门跟亚当都不是独生子女，会跟兄弟姐妹谈XING吗？22：16 亚当跟哥哥一起看过小电影？23：52 小电影在亚当家是一个兴松平常的事情24：21 小时侯撞见过父母的「甜蜜时刻」？26：55 桃乐丝、亚当、还有卡门有了小孩，会怎么跟小孩沟通XING27：28 桃妈给桃买了一本书——「如何成为一个男子汉」28：49 Q2——对象在微信跟别人聊骚，很露骨，不知道怎么办了？30：34 桃乐丝跟亚当在一起以后，也遇到过有人过来聊骚32：22 Q3——我喜欢了一个男生，他也喜欢我。可是他拒绝我了。34：29 亚当鼓励大家主动大胆去追求自己喜欢的人36：10 Q4——桃乐丝真的是猛一吗？38：19 卡门遇到假1的故事39：42 Q5——桃乐丝是怎么知道卡门的45码大臭脚的，有推特吗？我不信41：34 Q6——想成为卡门的弟弟，需要去哪里投简历？43：35 卡门会排斥跟听众朋友交往吗？44：44 Q7——想问下八分饱是怎么做到周更的？桃乐丝是时间管理达人吗？47：51 Q8——直女喜欢上一个弯弯怎么办？50：04 亚当：双XING恋真的存在，遇到这个问题怎么办？51：30 女生们请注意，清分清楚直男和弯弯！53：14 Q9——怎么才可以认识桃乐丝这么优秀的朋友？54：23 卡门：没有见过桃乐丝喝醉酒大哭不算认识桃乐丝56：01 亚当：送命题——5秒说出桃乐丝5个优点58：14 Q10——什么时候可以去卡门哥哥的卧室狂欢01：00：22 我们打算每10期做一期听众问问答环节！欢迎投稿！Intro music:Tai Verdes - A-O-K Cody Simpson - ABCBackground music: Fleetwood Mac - Dreams我们欢迎你投稿：同名微博私信email：papasanrenxing@163.com「八分饱ChannelAwesome」是一档由桃乐丝与卡门，两个在深圳生活的年轻人打造的都市生活类播客节目。WB：八分饱ChannelAwesomeWEB：ChannelAwesome.club商务：papasanrenxing@163.com

Vitamin B6 deficiency enhances the noradrenergic system, leading to behavioral deficits Tokyo Metropolitan Institute of Medical Science, May 27, 2021 Schizophrenia is a heterogeneous psychiatric disorder characterized by positive symptoms such as hallucinations and delusions, negative symptoms such as apathy and lack of emotion, and cognitive impairment. We have reported that VB6 (pyridoxal) levels in peripheral blood of a subpopulation of patients with schizophrenia is significantly lower than that of healthy controls. More than 35% of patients with schizophrenia have low levels of VB6 (clinically defined as male: < 6 ng/ml, female: < 4 ng/ml). VB6 level is inversely proportional to severity score on the positive and negative symptom scale (PANSS), suggesting that VB6 deficiency might contribute to the development of schizophrenia symptoms. In fact, a recent review has shown the decreased VB6 in patients with schizophrenia as the most convincing evidence in peripheral biomarkers for major mental disorders. Additionally, we recently reported that high-dose VB6 (pyridoxamine) was effective in alleviating psychotic symptoms, particularly the PANSS negative and general subscales, in a subset of patients with schizophrenia. Although a link between lower VB6 level and schizophrenia is widely hypothesized, the mechanism behind this remains poorly understood. VB6 is not synthesized de novo in humans, but is primarily obtained from foods. In the present study, to clarify the relationship between VB6 deficiency and schizophrenia, we generated VB6-deficient (VB6(-)) mice through feeding with a VB6-lacking diet as a mouse model for the subpopulation of schizophrenia patients with VB6 deficiency. After feeding for 4 weeks, plasma VB6 level in VB6(-) mice decreased to 3% of that in control mice. The VB6(-) mice showed social deficits and cognitive impairment. Furthermore, the VB6(-) mice showed a marked increase in 3-methoxy-4-hydroxyphenylglycol (MHPG) in the brain, suggesting enhanced NA metabolism in VB6(-) mice. We confirmed the increased NA release in the prefrontal cortex and the striatum of VB6(-) mice through in vivo microdialysis. These findings suggest that the activities of NAergic neuronal systems are enhanced in VB6(-) mice. Furthermore, VB6 supplementation directly into the brain using an osmotic pump ameliorated the hyperactivation of the NAergic system and behavioral abnormalities. indicating that the enhanced NA turnover and the behavioral deficits shown in the VB6(-) mice are attributed to VB6 deficiency in the central nervous system. In addition, the ?2A adrenergic receptor agonist guanfacine also improved the hyperactivated NAergic system in the frontal cortex and behavioral disorders. These results show that the behavioral deficits in VB6(-) mice may be caused by an enhancement of NAergic signaling. Schizophrenic patients with VB6 deficiency, who account for more than 35% of all patients, present with relatively severe clinical symptoms and treatment resistance. Our findings suggest that a new therapeutic strategy targeting the NAergic system might be effective for these patients. They will also provide evidence based on pathophysiology for a new therapeutic strategy called "VB6 treatment for schizophrenia," which we are currently conducting clinical research on.     Families with a child with ADHD can benefit from mindfulness training Radboud University Medical Center (Netherlands), May 27, 2021 Children with ADHD are generally treated with medication and/or behavioral treatments. However, medication-alone is insufficient in a quarter to a third of the children. For that reason, the scientists investigated whether a mindfulness-based intervention (MBI) would have a positive effect on children who did not respond sufficiently to other ADHD treatments. MBIs can elicit positive effects on psychological symptoms and behavior of children and parents.  In the study, two groups of children between the ages of eight and sixteen were compared. One group received only regular care (CAU, care-as-usual), and the other group also received MYmind, the mindfulness-based intervention (MBI) with at least one parent. They did this training for a period of eight weeks. A striking result was that parents especially benefited from this training. There was an increase in mindful parenting, self-compassion and an improvement in mental health among the parents. These effects were still visible six months after the end of the training. In the children, there were some effects on ADHD symptoms, anxiety, and autistic traits, but effects were small. Yet, a subgroup appeared to benefit: One in three children reliably improved on self-control following MYmind, whereas only one in ten improved when following only regular care. Professor of Environmental Sensitivity in Health and psychologist Corina Greven of Radboudumc, the Donders Institute and Karakter says that usual interventions for children with ADHD typically do not target mental health of parents, although they often struggle with parenting stress, anxiety or own ADHD symptoms. "While effects in children were small, we still found effects in the parents. Interviewing families , our team also discovered that many families reported important improvements in family relationships and insight in and acceptance of ADHD. We need to go broader than just looking at whether an intervention reduces symptoms, and include additional outcomes that families find important." The study was conducted in collaboration with the Radboud Center for Mindfulness.     Sweet cherry anthocyanins support liver health Zhei-Jang University (China), June 1, 2021 Anthocyanins from sweet cherries may protect against diet-induced liver steatosis, or excessive amounts of fat in the liver’s tissue, says a new study with rats.  The study , published in the journal Nutrition, built upon the abundant existing literature on the beneficial role anthocyanins have as an antioxidative, anti-inflammatory, and anti-hyperlipidemic component. Specifically, the cyanidin-3-glucoside variant “[has] been reported to ameliorate hepatic steatosis and adipose inflammation,” the researchers wrote. The condition known as liver steatosis is a common non-alcoholic fatty liver disease usually treated with drugs, but according to the researchers, some drug used for treatment “are usually accompanied by some adverse effect.” For 15 weeks, the researchers investigated the effects of sweet cherry anthocyanin supplementation have on alleviating high-fat diet-induced liver steatosis in rodents to explore the possibility of a none-drug treatment for the liver condition. Preparing the mice and the sweet cherry anthocyanins The sweet cherry anthocyanin was extracted and pulverized, with one mg of the anthocyanin measured to contain amounts of cyanidine-3-rutinoside and pelargonidin-3-rutinoside, among other things. Thirty male rodents were used for the study. The animals were housed five per cage and randomly divided into three groups: 10 rodents fed a low-fat diet, 10 rodents fed a high-fat diet, and 10 rodents fed a high-fat diet supplemented with sweet cherry anthocyanins. The supplementation was given in liquid form at 200 mg/kg orally at the same time daily for 15 weeks, and the body weights and food intakes were monitored weekly. Observations The mice were sacrificed at week 15 after a half-day fast. Blood samples were collected and livers collected, rinsed with cold saline, and then weighed. An automatic biochemistry analyser was used to measure total cholesterol, triacylglycerol, alanine aminotransferase, aspartate aminotransferase, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol. They found that at week 15, mice fed a high-fat diet supplemented with sweet cherry anthocyanins “displayed a significant reduction in body weight, liver weight, and liver index” compared to the mice that were only given a high-fat diet without supplementation. They also found the serum levels for tricylglycerol, total cholesterol, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol in high-fat diet mice to be substantially higher than those fed a low-fat diet, but the group supplemented with the anthocyanin resulted in a significant reduction in these serum parameters.” According to the researchers, the results demonstrated how sweet cherry anthocyanins may be developed into a supplement to “protect from high-fat diet-induced hepatic steatosis in mice,”leading to a suggested potential for the anthocyanin’s application in the “treatment of hepatic steatosis and other obesity related metabolic disorders.”     Healthy lifestyle linked to better cognition for oldest adults -- regardless of genetic risk New study suggests importance of maintaining healthy lifestyle even after age 80 Duke University & Kunshan University (China), June 1, 2021 A new analysis of adults aged 80 years and older shows that a healthier lifestyle is associated with a lower risk of cognitive impairment, and that this link does not depend on whether a person carries a particular form of the gene APOE. Xurui Jin of Duke Kunshan University in Jiangsu, China, and colleagues present these findings in the open-access journal PLOS Medicine. The APOE gene comes in several different forms, and people with a form known as APOE ε4 have an increased risk of cognitive impairment and Alzheimer's disease. Previous research has also linked cognitive function to lifestyle factors, such as smoking, exercise, and diet. However, it has been unclear whether the benefits of a healthy lifestyle are affected by APOE ε4, particularly for adults over 80 years of age. To clarify the relationship between APOE ε4 and lifestyle, Jin and colleagues examined data from 6,160 adults aged 80 or older who had participated in a larger, ongoing study known as the Chinese Longitudinal Healthy Longevity Survey. The researchers statistically analyzed the data to investigate links between APOE ε4, lifestyle, and cognition. They also accounted for sociodemographics and other factors that could impact cognition. The analysis confirmed that participants with healthy lifestyles or intermediately healthy lifestyles were significantly less likely to have cognitive impairment than those with an unhealthy lifestyle, by 55 and 28 percent, respectively. In addition, participants with APOE ε4 were 17 percent more likely to have cognitive impairment than those with other forms of APOE. A previous study suggested that in individuals at low and intermediate genetic risk, favorable lifestyle profiles are related to a lower risk of dementia compared to unfavorable profiles. But these protective associations were not found in those at high genetic risk. However, the investigation showed the link between lifestyle and cognitive impairment did not vary significantly based on APOE ε4 status which represented the genetic dementia risk. This suggests that maintaining a healthier lifestyle could be important for maintaining cognitive function in adults over 80 years of age, regardless of genetic risk.  This cross-sectional study emphasized the importance of a healthy lifestyle on cognitive health. While further research will be needed to validate these findings among different population, this study could help inform efforts to boost cognitive function for the oldest of adults. In the next step, the team will explore this association using the AD polygenetic risk score (AD-PRS) and explore the interactive relationship between AD-PRS and lifestyle on cognition with the longitudinal data.     Study shows BPA exposure below regulatory levels can impact brain development University of Calgary (Canada) June 1, 2021   BPA disrupts development of the mouse brain sleep centre (outlined), image on right. The change can impact behaviour. The control image on the left ("CON") shows sleep centre without BPA. Credit: Kurrasch lab, published in Science Advances Humans are exposed to a bath of chemicals every day. They are in the beds where we sleep, the cars that we drive and the kitchens we use to feed our families. With thousands of chemicals floating around in our environment, exposure to any number is practically unavoidable. Through the work of researchers like Dr. Deborah Kurrasch, Ph.D., the implications of many of these chemicals are being thoroughly explored. "Manufacturers follow standards set by regulatory bodies, it's not up to the manufacturers to prove the chemicals in consumer products are safe," says Kurrasch, a researcher in the University of Calgary's Hotchkiss Brain Institute (HBI) and Alberta Children's Research Institute at the Cumming School of Medicine. "Scientists play a critical role and do the meticulous work of determining where the risks lie." Kurrasch's research over the past decade has focused on a chemical that is broadly recognizable: Bisphenol A, also known as BPA. This chemical is commonly found in plastics, canned food linings, and even thermal receipts. Studies from Kurrasch's lab contribute to the collective research that shows the harms of exposure to this industrial compound. The latest study out of Kurrasch's lab, published in Science Advances, suggests that continued vigilance is needed. A postdoctoral researcher in her lab, Dr. Dinu Nesan, Ph.D., examined the impact of low levels of BPA exposure to pregnant mice and the brain development of their offspring. "Our goal was to model BPA levels equivalent to what pregnant women and developing babies are typically exposed to," says Kurrasch. "We purposefully did not use a high dose. In fact, our doses were 11-times and nearly 25-times lower than those deemed safe by Health Canada and the FDA (U.S. Food and Drug Administration), respectively. Even at these low levels, we saw effects on prenatal brain development in the mice." Using this BPA exposure model, Nesan found striking changes to the brain region responsible for driving circadian rhythms, the suprachiasmatic nucleus, located in the hypothalamus. When prenatally exposed to these low levels of BPA, the suprachiasmatic nucleus failed to develop properly. This change can have implications for sleep, activity levels, and other behaviors. "Previously we showed embryonic exposure to low-dose BPA can affect the timing of when neurons develop in zebrafish, but it was unclear whether a similar effect would be observed in a mammalian model with more similarities to humans," says Nesan, first author on the study. When neurons develop, they rely on proper signals to guide them. If neurons develop too early, the cues they experience are different, which can lead to developmental errors such as migrating to the wrong location, becoming the wrong type of neuron, or forming inappropriate connections. These errors can lead to altered behaviors later in life. "Our study shows that in pregnant mice, prenatal exposure to BPA affects the timing of neuron development in the fetal brain, which has lasting effects on behaviors. Offspring that are exposed to BPA during gestation are awake longer and exhibit hyperactivity. The prenatal BPA exposure seems to change the brain's circadian cues, causing the animals to have elevated energy levels and spend less time resting," says Nesan. The researchers are hopeful their findings will add continued pressure on regulatory bodies to keep revisiting their determinations around safe levels of BPA. "We think there's an incredible abundance of data showing BPA exposure guidelines are not yet at the appropriate level, which includes even the EU (European Union) who is leading on this front, but their 'safe' levels are still twice the dose we used in our study" says Kurrasch, "We hope our research serves as a reminder that low dose BPA is still capable of causing changes that are measurable and significant." Her message of how to interpret this research is simple: Limit your exposure to BPA the best you can.  Maintain smart practices with plastics in your kitchen, for example not heating them, and using glass or stainless steel when possible. This research was conducted in collaboration with Dr. Michael Antle, Ph.D., professor of psychology and member of the HBI.   Selenium plus CoQ10 intake associated with reductions in D-dimer and cardiovascular mortality Linköping University (Sweden), June 2, 2021 Findings from a randomized, double-blind, placebo-controlled trial, published on April 17, 2021 in the journal Nutrients,revealed a reduction in D-dimer levels among older Swedish men and women who received selenium and coenzyme Q10 (CoQ10), as well as a lower risk of mortality from cardiovascular disease in individuals having higher D-dimer levels at baseline.  Coenzyme Q10 is an antioxidant involved in the mitochondria’s production of energy. It has been estimated that the body’s production of CoQ10 at the age of 80 years is approximately half that of someone who is 20 years old.  Selenium is a trace element necessary for normal function of human cells. Dietary intake of this mineral may be insufficient in areas of the world that have low soil selenium levels. Selenium also is necessary for the function of many antioxidant enzymes, including one which recycles CoQ10, and has anti-inflammatory activity. D-dimer is a fragment of degraded fibrin and is commonly used to assess for the presence or degradation of potentially dangerous blood clots (venous thromboembolism or pulmonary embolism). It also reflects the activity of peripheral artery disease and has been shown to be associated with endothelial dysfunction and inflammation even in the absence of thromboembolism. The current investigation included 213 men and women aged 70 to 88 years who did not have conditions known to influence D-dimer concentrations (e.g., atrial fibrillation, malignancies). Participants received a placebo or 200 micrograms selenium plus 200 milligrams CoQ10 daily for four years.  Blood samples collected from the subjects upon enrollment in the trial and at 48 months were analyzed for levels of D-dimer. Although D-dimer levels were not significantly different between groups at the beginning of the trial, it was noted to be significantly associated with age. At 48 months, a significantly lower level of D-dimer was found among those who received selenium and CoQ10 in comparison with the placebo, which was maintained after adjustment for co-variates that might influence D-dimer (such as C-reactive protein).  When participants with D-dimer levels that were above the median of all participants at baseline were analyzed, an association was found between intake of selenium and CoQ10 and a lower risk of cardiovascular mortality. Among those whose D-dimer levels were higher than 0.21 mg/L at the beginning of the study, one person among 53 who received selenium and CoQ10 died during a median 4.9-year follow-up period compared to 8 of the 52 who received a placebo. Mortality from all causes was also lower in the selenium and CoQ10 group; however, the reduction failed to reach statistical significance. This group also reported a larger study, which didn’t exclude individuals having conditions known to increase D-dimer, finding that in the older Swedish citizens the combination of selenium and CoQ10 significantly increased heart systolic function, lowered NT-proBNP (which is elevated during heart failure) and decreased risk of cardiovascular mortality, defined as death from myocardial infarctions, cerebrovascular lesions, cardiac arrythmias, heart failure or aortic aneurysms.1 “[Intake of] selenium and coenzyme Q10 in a group of elderly low in selenium and coenzyme Q10 prevented an increase in D-dimer and reduced the risk of cardiovascular mortality in comparison with the placebo group,” concluded first author Urban Alehagen and his colleagues. “The obtained results also illustrate important associations between inflammation, endothelial function and cardiovascular risk.”     Effect of Korean Red Ginseng on Cognitive Function and Quantitative EEG in Alzheimer Patients Seoul Medical Center  (Korea) June 1, 2021 Researchers detail new data in Neurodegenerative Diseases. According to news reporting originating in Seoul, South Korea  research stated, "Korean red ginseng (KRG) has a nootropic effect. This study assessed the efficacy of KRG on cognitive function and quantitative electroencephalography (EEG) in patients with Alzheimer's disease (AD)." The news reporters obtained a quote from the research from Seoul Medical Center, "Fourteen patients with AD (mean age, 74.93 years; 11 women and 3 men) were recruited and treated with KRG (4.5 g per day) for 12 weeks. Cognitive function was assessed by the Korean Mini-Mental State Examination (K-MMSE) and the Frontal Assessment Battery (FAB). EEG performed before and after treatment were analyzed with quantitative spectral analysis. The FAB score improved significantly after 12 weeks of treatment. In the relative power spectrum analysis performed according to responsiveness, alpha power increased significantly in the right temporal area of the responders. The increments of relative alpha power in the right temporal, parietal, and occipital areas were significantly higher in the responders than the nonresponders." According to the news reporters, the research concluded: "This study indicates the efficacy of KRG on frontal lobe function in AD, related to increasing relative alpha power."

V 89. epizodi podcasta Lovim ravnotežje bova govorili o temi, ki je tudi meni predstavljala velik izziv in po kateri me veliko sprašujete – kako postaviti meje, kakšno vlogo pri tem igra osvajanje besede ne in zakaj je to pomembno tudi za odnos, ki ga imamo same s seboj. V tej epizodi bova govorili o tem, kako začeti s postavljanjem zdravih mej, ki ti bodo v pomoč pri oblikovanju zdravega in lepega odnosa s seboj in drugimi, kako prenehati s stvarmi, ki jih delaš zato, da izpolniš pričakovanja (ali zahteve) bližnjih in kako pri vsem tem uporabiti najbolj pomembno besedo v našem jeziku, besedo ne. Ne pozabi skočiti na spodnjo povezavo, kjer te v zapisu epizode čakajo vse informacije in dodatne povezave, ki sem jih omenila v epizodi. ZAPIS EPIZODE: https://ninagaspari.com/epizoda89/ 89. epizoda podcasta Lovim ravnotežje je nastala v sodelovanju s podjetjem Malinca, ki že osem let svojo blagovno znamko ekološke prehrane in naravne kozmetike uspešno nadgrajuje tudi s kakovostnimi in naravnimi prehranskimi dopolnili. Malincin novi izdelek koencim Q10 koristen za lepo in napeto kožo, srce in krvni obtok, za boljši spomin, pomaga pri zdravljenju srčnih bolezni, zdravi bolezni dlesni in jih ohranja zdrave, varuje živčevje in upočasni starostne degenerativne spremembe v telesu. Več informacij o izdelku in njegovih prednostih pa dobiš v zapisu epizode. Ob nakupu uporabi kodo ravnotezje10 in ujemi še 10% popust. Vabim te, da se prijaviš na e-novičnik. S prijavo boš dobila popust za nakup e-vsebin v spletni trgovini in dodatne vsebine, ki jih pripravljam le za naročnice novičk. Takoj ob prijavi boš v svoj nabiralnik prejela popust in moje počasne jutranje rutine, s katerimi poskrbim, da v vsak dan vstopim na najboljši način. Naročiš se lahko prek https://ninagaspari.com/newsletter/ V spletni trgovini te že čakajo krasne e-knjige in e-delovni zvezki: https://ninagaspari.com/shop/ Ujameš me lahko tudi na: INSTAGRAM: https://www.instagram.com/ninagaspari/ FACEBOOK: https://www.facebook.com/iamninagaspari/ TWITTER: https://twitter.com/ninagaspari SPLETNA STRAN: https://ninagaspari.com/

Det vitaminbeslægtede stof coenzym Q10 er hovedsageligt kendt for sin rolle i cellernes energiomsætning, men iranske forskere har opdaget, at det kan mindske den inflammation, som plager folk med tarmsygdommen ulcerøs colitits.

Coenzym Q10 ist ein Liebkind der Kosmetik-Industrie. Eine Vielzahl an Pflegeprodukten zählen auf den bewährten Wirkstoff, doch auch ausgewählte Nahrungsergänzungen verwenden ihn gezielt. Auch Experten der Orthomolekularmedizin betonen die Bedeutung von Q10 für den gesamten Energiehaushalt des Menschen. Doch was steckt nun dahinter?

Thank you for joining us for our 2nd Cabral HouseCall of the weekend! I’m looking forward to sharing with you some of our community’s questions that have come in over the past few weeks… Let’s get started!    Jen: We always hear about Hemoglobin A1C being too high and that being a concern, but I'd like to understand if Hemoglobin A1C can be considered too low. If so, what would cause that/ what can be done for it? I learned in IHP that ideal range is 4-5.6, but my number is 3.6 on my lab test. I struggle with hypoglycemia symptoms, could that be related? Karima: Hi Doc! Love love love your content, you're doing an incredible job! I am a 23 year old healthy woman that is trying to optimise my health as much as possible. I've done several of your protocols (parasites, detox, cbo, cbo finisher), exercise regularly, sleep well, meditate, eat well, take the DNS, omega 3, zinc, magnesium, vitamin D, CBD oil, B complex and digestive enzymes on a daily basis. I'm diving deeper and deeper into biohacking because I want to optimise my performance at work (I'm an entrepreneur) and just started taking Coenzyme Q10 on top of my other supplements. Also started adding a tsp of mct oil to my daily smoothies. My questions are: 1. Do you think there will be a detrimental effect of taking coenzyme Q10 if I'm just 23? Could my body develop a dependency to it? 2. Any other supplements that you have seen in your experience that are great for boosting mental performance (creativity, focus & efficiency)? Tab: Hi! First off, thanks for all you do! I’ll be joining the IHP school in the fall and have already started directing people I love in your direction for their health & wellness needs. My question is about metabolism. I’ve heard someone say recently that to speed up metabolism is actually not good for longevity due to it being accelerated cell division. They equated accelerated cell division to early aging/death. Their point was to eat things that are more nutritionally dense so that our body uses it better. Long story short, I’m just conflicted on the issue of metabolism and want to be able to coach my clients with the truth. Thanks again and God bless! Jacquie: Hi Dr. Cabral, I hope you're having a good day! I'm an IHP and I'm writing on behalf on my 27 yr old client. He has completed the big 5 and we've been working the process (modified CBO, HM detox, 21 DCD). He's lost over 20 pounds and feels generally healthier. The only issues remaining are the swelling on the whole right side of his body and sometimes pain in his lower right abdomen. My question is why the swelling just on one side? I could see if he had an injury to a specific area that could cause swelling, but it just seems odd to be the whole right side of his body. He does have one kidney that is quite smaller than the other, but all the conventional medicine tests and the big 5 lab results came back saying his kidneys are healthy/functioning normally. Any ideas of where to look next? Thank you for all that you do! Lina: Hello, Been listening to your podcast for a few years now, and it has completely changed my life!  My fasted sugar is between 110 and 120, not the Big 5, or 21 day detox ( not even during it), Fatlossity, or other types of yearly cleanses helped me find the cause/solution for that number; the only time I managed to keep it under 100 was while doing keto for 6 months/counting macros.  Your podcast educates me enough to know I don't want to do that as my long term lifestyle choice.  I'm trying to eat a mostly plan based, gluten free, fiber fueled diet. I exercise 3 times a week and go beyond 12,000 steps daily, have my last meal at least 3 hrs before bed, take berberine and sleep well, ... so apparently I'm doing all the right things for the past 3 years and nothing seems to help me lower that number. I also struggle with weight loss.  My endocrinologist said nothing could be done right now, but to wait a few years until I actually did become diabetic and then I could get a prescription that could help me manage it.  I don't want to follow that advice. I want to continue trying to find the root cause and stop it from becoming diabetes, since it runs in my family. I don't know where to look next.  thank you for giving us this space. Sarah: I’ve noticed that when I eat a lot of processed foods & sugar, not only do I get the immediate bloating and puffiness the next day, but when I keep that up for several consecutive days, the areas around my genitals, anus and left armpit gets itchy and I get little bumps which might be hives. My affected armpit gets a distinct yeasty smell and stops emitting regular body odor. I’m aware this has something to do with Candida overgrowth, but can you tell me why I get itchy in those specific areas? It’s like my tell tale sign that I’ve overdone it and need to get back on track with healthy eating. I just want to understand why this happens. Thank you! Thank you for tuning into this weekend’s Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right! - - - Show Notes & Resources:  http://StephenCabral.com/1927 - - - Dr. Cabral's New Book, The Rain Barrel Effect https://amzn.to/2H0W7Ge - - - Join the Community & Get Your Questions Answered: http://CabralSupportGroup.com - - -  Dr. Cabral’s Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Stress, Sleep & Hormones Test (Run your adrenal & hormone levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels)

Jaume Segalés y los responsables de Mundo Natural hablan de salud y de ejercicio y Q10 para las mitocondrias.

Las plazas traseras de los coches no son como las delanteras en muchos ámbitos, hoy compartimos la inquietud de una familia por la seguridad de sus hijos. Esta semana nos ha llegado una consulta que es más habitual de lo que podría parecer y que precisamente con la llegada al mercado de más modelos SUV coupé aumenta. Nos llama una familia para preguntarnos si es seguro poner al niño mayor en un alzador sin protección en cabeza con 135cm, su SRI no se puede elevar más porque pega en el pilar C del coche y sin embargo el SRI, de no ser por el pilar C si podría proteger al niño hasta los 150 cm aproximadamente con la protección en cabeza. https://www.rivekids.com/hasta-cuando-tiene-que-ir-un-nino-en-silla-de-coche/ La pregunta tiene mucha miga, pero antes de nada recordar que debemos leer las instrucciones de la silla de coche y del propio coche. En el manual de la silla que tenía esta familia ponía claramente en que modelos la silla solo se puede usar hasta los 135 cm aproximadamente en los laterales por ese contacto con el pilar C. Además la familia reflexionaba sobre que pasaría cuando el niño midiera más de 170 cm y es que no se habían parado a pensar que en ese momento y en adelante tocaría con la cabeza en el pilar C… Las plazas traseras son el gran olvidado del confort y seguridad en los coches normales y evidentemente no todas las familias pueden acceder a un Mercedes Clase S. https://www.mercedes-benz.es/passengercars/mercedes-benz-cars/models/s-class/saloon-wv223/explore/highlights.module.html ¿Qué alternativas tiene esta familia? - Llevar al niño sin ningún sistema de retención infantil, solo con el cinturón de seguridad, la ley se lo permite. https://www.rivekids.com/que-es-mejor-isofix-o-cinturon-de-seguridad/ - Llevar al niño en un alzador sin respaldo, como se hacen los test en Euro NCAP para el dummy Q10. https://www.euroncap.com/es - Buscar una silla de coche con respaldo que permita apurar más la protección en cabeza. ¿Existe ese sistema de retención infantil? En esa búsqueda encontramos un modelo que no está a la venta pero que promete estarlo en breve y que es muy especial: https://casualplay.com/es/sillas-de-coche/backfix-i-size Es un nuevo concepto de SRI para niños mayores con isofix, protección en cabeza hasta los 150 cm pero sin base. Es de homologación R129 y manteniendo la guía del cinturón en las caderas prescinde de los 5 o 10 cm de la base del resto de sistemas de retención infantil de este tipo. https://www.rivekids.com/2018-normativa-r129-i-size/ ¿Puede ser esta una solución? Sobre el papel si, pero por el momento en RiveKids no hemos podido verificar si en estático y dinámico cumple todo lo que promete. Hasta aquí el programa de hoy del podcast de seguridad vial y educación vial de rivekids. Para un asesoramiento 100% personalizado te esperamos en atencion.cliente@rivekids.es También puedes seguirnos en https://www.rivekids.com/ Instagram RiveKids: https://www.instagram.com/rivekids/ Twitter RiveKids: https://twitter.com/RiveKids Facebook RiveKids: https://es-es.facebook.com/rivekids Linkedin RiveKids: https://es.linkedin.com/company/rivekids “El verdadero viaje es el que termina como comenzó, con felicidad e inocencia” Feliz viaje hasta el próximo programa.

This week, Stacey is joined by Igor Gorsky, author of Principles of Parenteral Solution Validation, A Practical Lifecycle Approach. Stacey and Igor discuss the history of Parenteral Process Validation and why the resources in this manual are so important in this day and age.   Resources from this episode: Principles of Parenteral Solution Validation: A Lifecycle Practical Approach written by Igor Gorsky and Harold Baseman, published by Elsevier Process Validation: General Principles and Practices - FDA ICH guidance Q8 Pharmaceutical Development published May 2006 Q&A for the current working procedure for implementing the Q8, Q9, and. Q10 guidance's Slides referenced by Igor   Igor is the principal consultant at Valsouce Inc. He also is a Pharmaceutical and Biotechnology Industries’ Leader with broad strategic and tactical leadership experience spanning Development, Commercial Manufacturing, and Quality organizations. Proven record in implementing Validation Master Plans based on Risk Management and principles outlined in ICH Guidances Q8, Q9, Q10, and Q11 in a variety of pharmaceutical facilities. Expertise in implementing Quality by Design in the manufacturing environment throughout commercial product launch. Proven track record in building Validation organizations, establishing and implementing validation policies and training programs. Direct personal interface with FDA, MHRA, ANVISA, and other regulatory organizations.   Voices in Validation brings you the best in validation and compliance topics. Voices in Validation is brought to you by IVT Network, your expert source for life science regulatory knowledge. For more information on IVT Network, check out the website at http://ivtnetwork.com.

Alie Wouda-van der Tuin laat weten welke kruiden zij inzet binnen haar natuurpraktijk Aurora.Ineke Haisma (orthomoleculair therapeut) laat weten wat AGE’s zijn. Deze afkorting staat voor: advanced glycation end products.Orthomoleculair deskundige Jan Blaauw vertelt over de waarde van co-enzym Q10. The post 01-04-2021, uur 1 appeared first on Gezondheidsnieuws Radio.

Det aktive stof i smertestillende præparater som paracetamol hedder acetaminofen og kan ved overdosering give potentielt livstruende leverskader. Nu skriver kinesiske forskere, at det naturligt forekommende stof, coenzym Q10, som danner energi i cellerne, virker til at have en beskyttende effekt.

Salut, c’est Madame Meuf ! L’autre jour, nous patientions derrière un bus avec ma fille, avec une pub pour une crème antiride Q10, et ma fille me dit "Dis maman, pourquoi la fille pour la crème antirides elle est ado ?". Bonne question ma chérie ! L’âge des meufs, des madames, on va causer de ça dans cet épisode, et de comment le féminisme peut nous aider là-dedans ! See acast.com/privacy for privacy and opt-out information.

Q10 . Can you sort multiple columns at one time? --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app

Lucía Prieto habla con ayuda de los mejores especialistas de Mundo Natural de salud mitocondrial y la Q10.

Jaume Segalés y los responsables de Mundo Natural hablan de salud, del ejercicio, del Q10 y de las microbiotas. 

Today on the podcast I have the pleasure of talking to Bernard Sia and Stephen Chian. For the past two years, I've been fortunate enough to be a part of the End Polio Now Ride. It's a charity ride to raise awareness and funds to End Polio Now.   Bernard Sia was in charge of the actual activity and putting it together.   Stephen Chian was on the fund raising side and where the aid goes.   Enjoy the podcast.      Where can you find them? http://rotarycebu.org/ https://www.facebook.com/rotarycebu           This podcast is sponsored by Bix Recovery Supplement. I’ve been using Bix Recovery Supplement as one of the key hydration mixes after a bicycle ride. It’s got all the good stuff in it – vitamin C, Zinc, Vitamin E, Q10, Bromelain, calcium, magnesium, BCAA, potassium, iron and sodium. Learn more and orders yours at https://www.instagram.com/focusrecoveryph Music in the podcast Piano March by Audionautix Support the show: (1) Become a Patreon subscriber – https://www.patreon.com/zerothreetwo (2) Share this episode on social media. More: http://zerothreetwo.com/monday

I have many things in common with my childhood friends. One of those things is that we are all parents! So I knew it was going to be fun to talk about that, compare notes, and just hang out. So I talked to Jason Almendras and Blue Cuevas. Blue is a new parent so we wanted to catch up with him and see how he was doing. Enjoy!   Where can you find them? https://www.instagram.com/jasonalmendras/ https://www.instagram.com/bluescue/ This podcast is sponsored by Bix Recovery Supplement. I’ve been using Bix Recovery Supplement as one of the key hydration mixes after a bicycle ride. It’s got all the good stuff in it – vitamin C, Zinc, Vitamin E, Q10, Bromelain, calcium, magnesium, BCAA, potassium, iron and sodium. Learn more and orders yours at https://www.instagram.com/focusrecoveryph Music in the podcast Piano March by Audionautix Support the show: (1) Become a Patreon subscriber – https://www.patreon.com/zerothreetwo (2) Share this episode on social media. More: http://zerothreetwo.com/monday

Snoogie Reynes-Mata is one of the most sought after wedding and events planner in Cebu, Philippines. Back when we were planning our wedding, many of our friends spoke very highly of her. Of course, she became our wedding organizer.   In this episode, we talked about having a 9-5 while doing a sideline, when that sideline starts taking more of your attention, the secret to getting good clients, and weddings in the new normal.   Enjoy!   Where can you find Snoogie? https://www.facebook.com/snoogie.reynesmata https://www.instagram.com/snoogie_reynes_mata/     This podcast is sponsored by Bix Recovery Supplement. I’ve been using Bix Recovery Supplement as one of the key hydration mixes after a bicycle ride. It’s got all the good stuff in it – vitamin C, Zinc, Vitamin E, Q10, Bromelain, calcium, magnesium, BCAA, potassium, iron and sodium. Learn more and orders yours at https://www.instagram.com/focusrecoveryph Music in the podcast Piano March by Audionautix Support the show: (1) Become a Patreon subscriber – https://www.patreon.com/zerothreetwo (2) Share this episode on social media. More: http://zerothreetwo.com/monday

Chai Fonacier is a Filipino theatre and film actress, as well as a singer/songwriter. She is also the songwriter and vocalist of the Cebuano trip hop band Womb. Her acting work for the short film Operation Prutas (2015) garnered her a Best Supporting Actress award in the 2015 Sinulog Film Festival. In November 2015, she won Best Supporting Actress for her role in the Cinema One Originals film Miss Bulalacao.   In this episode, we talk about acting in the new normal, where to watch good Filipino movies, the experience of moving to Manila, a shift in the conversations in show business, and being hopeful with the internet.   Enjoy!     SHOWNOTES Womb Ara Chawdhury (Zerothreetwo Conversations episode) Christian Linaban (Zerothreetwo Conversations episode) Miss Bulalacao Pista ng Pelikulang Pilipino iWant Di Ingon Nato Damgo Ni Eleuteria Confessional Hintayan Ng Langit Born Beautiful Remton Zuasola Victor Villanueva (Zerothreetwo Conversations episode) Superspychocebu Patay na si Hesus Gary Granada Cooky Chua Bayang Barrios Dong Abay Sutukil Sauce   Where can you find Chai? https://www.instagram.com/chaifonacier/ https://rabidchai.wordpress.com/   This podcast is sponsored by Bix Recovery Supplement. I’ve been using Bix Recovery Supplement as one of the key hydration mixes after a bicycle ride. It’s got all the good stuff in it – vitamin C, Zinc, Vitamin E, Q10, Bromelain, calcium, magnesium, BCAA, potassium, iron and sodium. Learn more and orders yours at https://www.instagram.com/focusrecoveryph Music in the podcast Piano March by Audionautix Support the show: (1) Become a Patreon subscriber – https://www.patreon.com/zerothreetwo (2) Share this episode on social media. More: http://zerothreetwo.com/monday  

  In 2016, we started a podcast called 3rd World Startup with Kahlil Corazo, Carlo Villarica, Robert Li and Kenn Costales. This is the reunion show.   In this episode,we talk about what we've changed our mind about in the past few years, exercise, the E-Myth, strengths finder, knowing yourself, roam research and a lot more.   Enjoy!     SHOWNOTES 3rd World Startup Podcast WP Engine Monolith Roam Research uulanba     Where can you find them? https://www.instagram.com/iamthechumtographer/ https://www.instagram.com/kennyfrc/ https://twitter.com/kcorazo   This podcast is sponsored by Bix Recovery Supplement. I’ve been using Bix Recovery Supplement as one of the key hydration mixes after a bicycle ride. It’s got all the good stuff in it – vitamin C, Zinc, Vitamin E, Q10, Bromelain, calcium, magnesium, BCAA, potassium, iron and sodium. Learn more and orders yours at https://www.instagram.com/focusrecoveryph Music in the podcast Piano March by Audionautix Support the show: (1) Become a Patreon subscriber – https://www.patreon.com/zerothreetwo (2) Share this episode on social media. More: http://zerothreetwo.com/monday

Every month, I  have a Mastermind group session - it's a group of people who meet regularly to talk about our goals (business, personal, etc.), provide feedback with each other, and allows for accountability. It's been super helpful for me. This is a recording of one of our Mastermind sessions.  In this session, it's Johnn Mendoza, Kahlil Corazo and Mark Cortes (catches up in the one hour mark). Below is the shownotes for this particular session. Mastermind - October 22, 2020, 2:30pm Wins Kahlil: accessiblegenomics.com, progress with teaching online Johnn: hotel, biking, lifting, learning how to change breakpads Carlo: officially monetized in YouTube, social media client back Macoy: one of the few kept in job after layoffs, about to buy house, finished How to Win Friends   Challenges Kahlil: MSc exams Johnn: distribute eBikes: changing perception of eBikes, reading, cardio Carlo: no help Macoy: still going through whole pandemic, chugging along (the ship is in the right direction) Goals Kahlil: study, finish sem well Johnn: reopen hotel, go back to vlogging, 100km ride Carlo: 3 videos, 1 podcast, newsletter per week, social media work. Long term: bet on self Macoy: read more, learn more   Cool things Kahlil: The Discipline http://metalbat.com/post/the-discipline/ Johnn: denatured alcohol, foam cleaner, compost (compost, african night crawlers) Carlo: David Attenborough Life on Planet Macoy: why buy a house: worst case, I won’t be homeless. Tom Myers comedian       SHOWNOTES Roam Research Antifragile Nassim Taleb Naval Ravikant How to Win Friends and Influence People Never Split the Difference Skin in the Game Gino Reyes (Zerothreetwo Conversations episode) Brian Grazer     Where can you find them? Kahlil Corazo - https://twitter.com/kcorazo Johnn Mendoza - https://www.youtube.com/channel/UCPVxtHe_TV6QeGNTAdI0XRg Mark Cortes - https://www.instagram.com/mellow_machine/     This podcast is sponsored by Bix Recovery Supplement. I’ve been using Bix Recovery Supplement as one of the key hydration mixes after a bicycle ride. It’s got all the good stuff in it – vitamin C, Zinc, Vitamin E, Q10, Bromelain, calcium, magnesium, BCAA, potassium, iron and sodium. Learn more and orders yours at https://www.instagram.com/focusrecoveryph Music in the podcast Piano March by Audionautix Support the show: (1) Become a Patreon subscriber – https://www.patreon.com/zerothreetwo (2) Share this episode on social media. More: http://zerothreetwo.com/monday

Monica Villarica began dancing at the age of 2 under the direction of her grandmother, Fe Sala Villarica. In 2004, she joined her first CCP Summer Dance Workshop in Manila on partial scholarship. Along with intensive training in Classical Ballet, she was also exposed to Modern Dance. This experience opened her eyes to the world of professional dance and inspired her to continue spending her summers with CCP Dance School on full scholarship until 2006.   Since then she has had plenty of experience in dance, notably a scholarship in CCP Dance School, an apprenticeship in Ballet Philippines, and studied in The Ailey School in New York,   And of course, she is my sister.   In this episode, we talked about choosing dance as a career, life as a dancer, auditioning as a dancer, starting online dance classes, plans changing because of the pandemic, and lots of brother sister banter.   Enjoy!     SHOWNOTES Miki Villarica Fe Sala Villarica Noordin Jumalon Nicholas Pacaña Rhea Dumdum Bautista (Ate Iya) Sheila Lendio-Manlunas Rhosam Prudenciado Jr. MDF Productions Peter Attia podcast with Beth Lewis Myles Delfin (Zerothreetwo Conversations episode) The Bike Scouts Project   Where can you find Monica? https://www.instagram.com/vidacebu/ https://www.facebook.com/vidacebu https://www.instagram.com/monvsushi/       This podcast is sponsored by Bix Recovery Supplement. I’ve been using Bix Recovery Supplement as one of the key hydration mixes after a bicycle ride. It’s got all the good stuff in it – vitamin C, Zinc, Vitamin E, Q10, Bromelain, calcium, magnesium, BCAA, potassium, iron and sodium. Learn more and orders yours at https://www.instagram.com/focusrecoveryph   Music in the podcast Piano March by Audionautix   Support the show: (1) Become a Patreon subscriber – https://www.patreon.com/zerothreetwo (2) Share this episode on social media.   More: http://zerothreetwo.com/monday  

Listen to this uplifting conversation with a renowned and award-winning  keynote and TEDx speaker, emcee, author, and host of the amazing "Making  Waves" podcast, Thom Singer. He is an incredibly bright and generous  individual and a well-rounded professional who speaks with me about how  he became the master of the art of speaking, the power of deep human  connections, relationships, networking, and his current quest to  reinvent himself in a virtual and distracted world (you can listen to  the full audio version of the @Alloutcoach Podcast episode available on  all podcast platforms - link to the episode: http://www.anchor.fm/alloutcoach).     Life requires different versions of you and different parts of your  character at different the different stages of life. When you form a  family, become a parent, or have a stable, long-term relationship for  the first time, when you are promoted to new responsibilities, or  experience a job or a different loss in life or a failure, life teaches  you to reinvent yourself. And it is always other people with whom you  form deep and meaningful connections and relationships over time that  help you rise up in the ranks, endure difficult times, and transform  your career or personality whether before or after the pandemic. Thom  reveals his own transformation throughout life, his endless curiosity,  and evident bright personality and intellect which has allowed him to  win multiple speaking awards, write books, host conferences, coach  presentation skills and speech-writing, lead marketing and business  development functions in the corporate environment, just to name a few.  He has had celebrity keynote speakers as personal mentors across many  industries and shares illustrious stories about the richness of his life  and experiences, and shares tips on agility and leadership by  reinventing yourself in a distracted and lonely world in which we have  all become so accustomed to live. Timeline of the Podcast   00:56 - Q1: How did you make waves in the beginning?   02:39 - Q2: What role did mentors play in your rise in the ranks? 06:09 - Q3: How did you pivot to become a speaker? 07:54 - Q4: Did you have separate coaches for different skills/talents? 09:48 - Q5: How did you land your first TEDx gig? 11:47 - Q6: How do you find the source of energy when you present? 12:57 - Q7: What role has sports played in your life? 14:31 - Story about Legacy in a Corporate Company Culture Initiative 15:25 - Q8: How do you stretch yourself and pivot during COVID19? 20:44 - Q9: Are coaches important to next generation leaders due to loneliness, distraction, and specialization? 23:18 - Q10: How has marketing transformed as a function over the years based on his experience? 26:34 - Power of Personal Referrals and Human Connections vs. Social Media Likes and # of Followers 36:54 - Q11: What were the characteristics of his most memorable presentations?  39:26 - Q12: Best advice to next generation leaders to make their presentations more memorable? 41:52 - Recognition of other master keynote speakers with an impact on Thom's life --- Support this podcast: https://anchor.fm/alloutcoach/support

    Jullian Sibi is a software engineer who turned his passion of tech into his blog, utterlyrandomtechie.com, that makes sense of the techie life. His interactions with fellow creatives led him to start a podcast, The Creator Life, an interview/conversation podcast that finds out how different creators live.   In this episode, we talk about the future of podcasts, Spotify possibly being the YouTube of podcasts, live streams, what you get from podcasts, attention spans and looking back at 2020.   Enjoy!   SHOWNOTES The company Cebu Internationalpodcastday.com Marketoonist - the productivity trap   Where can you find Jullian? https://www.utterlyrandomtechie.com/ https://anchor.fm/thecreatorlife     This podcast is sponsored by Bix Recovery Supplement. I’ve been using Bix Recovery Supplement as one of the key hydration mixes after a bicycle ride. It’s got all the good stuff in it – vitamin C, Zinc, Vitamin E, Q10, Bromelain, calcium, magnesium, BCAA, potassium, iron and sodium. Learn more and orders yours at https://www.instagram.com/focusrecoveryph Music in the podcast Piano March by Audionautix Support the show: (1) Become a Patreon subscriber – https://www.patreon.com/zerothreetwo (2) Share this episode on social media. More: http://zerothreetwo.com/monday

Episódio #112 no ar! Nele, conversamos com o médico Vitor Azzini (@drvitorazzini) que é um grande profissional que preza pela boa ciência e qualidade de vida. Dr. Vitor quebrou alguns mitos ao explicar sobre alguns temas como: A relação entre consumo de fibras e constipação; Consumo de leite; Consumo de grãos e cereais; Suplementação (vitamina D, coenzima Q10 e magnésio); Consumo de carnes; Cuidados ao consumo excessivo de vegetais; A importância da qualidade do sono; E muito mais... Nosso podcast está nas principais plataformas e também em nosso site: www.atletaslowcarb.com.br

Carlo Bien Clavano de Asis is one of the guys of Aframe Surf Company. I happen to have had the pleasure of joining Carlo Bien in a surf trip. One of the best trips of my life.   In this episode, we talk about running, the basics of stand up paddle (SUP), the sketchiest thing that happened to him on an SUP, the magic of Lanuza, cancelled trips and secret surf spots.   Enjoy!   SHOWNOTES Terence Go (Zerothreetwo Conversations episode) Meux Cordova Lorenz Florendo Ares Kintanar Windy MagicSeaweed Hale Manna Eric Smith (Zerothreetwo Conversations episode) Niconiks Ybanez (Zerothreetwo Conversations episode) Mozart Reina (Zerothreetwo Conversations episode)   Where can you find CarloBien? https://www.instagram.com/aframesurfcompany/ https://www.facebook.com/aframesurfcompany   This podcast is sponsored by Bix Recovery Supplement. I’ve been using Bix Recovery Supplement as one of the key hydration mixes after a bicycle ride. It’s got all the good stuff in it – vitamin C, Zinc, Vitamin E, Q10, Bromelain, calcium, magnesium, BCAA, potassium, iron and sodium. Learn more and orders yours at https://www.instagram.com/focusrecoveryph Music in the podcast Piano March by Audionautix Support the show: (1) Become a Patreon subscriber – https://www.patreon.com/zerothreetwo (2) Share this episode on social media. More: http://zerothreetwo.com/monday  

A conversation with my childhood friends. Mark Cortes, Jeremie Lim, Jason Almendras, Blue Cuevas.   In this episode, we give each other an update on COVID in our respective countries, talk about having kids for the first time, Blue's coin hunting hobby, Gov. Gwen suing Chong Hua, Nihilism, cancel culture, and basketball.   Enjoy!   SHOWNOTES Terence Go (Zerothreetwo Conversations episode) Rescue a Hero   Where can you find the guys? https://www.instagram.com/mellow_machine/ https://www.instagram.com/jeremiespoken/ https://www.instagram.com/jasonalmendras/ https://www.instagram.com/bluehuntscoins/   This podcast is sponsored by Bix Recovery Supplement. I’ve been using Bix Recovery Supplement as one of the key hydration mixes after a bicycle ride. It’s got all the good stuff in it – vitamin C, Zinc, Vitamin E, Q10, Bromelain, calcium, magnesium, BCAA, potassium, iron and sodium. Learn more and orders yours at https://www.instagram.com/focusrecoveryph Music in the podcast Piano March by Audionautix Support the show: (1) Become a Patreon subscriber – https://www.patreon.com/zerothreetwo (2) Share this episode on social media. More: http://zerothreetwo.com/monday  

Part 1: From One Dropout to Another [04:00]Chloë started Wander Films with business partner Lou Tonner after returning from a soul-searching experience in Australia. She describes her life as a dropout in the North East and how Australia changed their outlook on life.Key QuestionsQ2: Can you give us a tour of your life before Australia? [04:10]Q3:  What was creative life like in the North East and why did you choose to go to Australia? [08:20]Q4: What is your view on qualifications, do they matter?  What would you say is your qualification? [10:15]Part 2: Riding the Video Wave in Business [12:58]Wander films is known for their 'Epic Vlog Package', which helps businesses create engaging videos to tell their stories and grow their audiences. Chloë talks in more detail about Wander Films and what has earned them recognition as film makers so far.Key QuestionsQ5: Firstly, of all film-making possibilities you could have pursued, why did you choose to focus on business storytelling? Secondly, using an example, what is the Epic Vlog Package exactly?[13:06]Q6:  How would you describe your style in terms of the content you produce and the way you interact with clients? [20:27]Q7: As a startup what do you have to do to earn that recognition? [21:53]Part 3: How to Beat the Scroll [25:50]It is hard to capture attention in the online sphere as it is oversubscribed by potentially valuable content.  We discuss how Wander Films help clients' achieve this from a personal and professional point of view.Key QuestionsQ9: Can you talk us through some of the initial challenges and surprising successes of Wander Films? [25:57]Q10: How do you beat the scroll (from a personal, professional and client’s point of view)? [29:36]Q11: Have you ever worked on a project you lacked motivation for? How do you go about delivering an awesome project regardless of your personal connection to it? [32:00]Q12: How do you see the world? [35:19]Resources MentionedFilm: Primal Fear (1996)Podcast: My Favourite MurderChloë Clover's YouTube channelFind out more about Wander Films Ltd, Epic Vlog Package and other video solutions for businesses here: https://wander-films.co.uk/ (or find  on any of the social media channels @WanderFilmsUK). Have you Tried our App?We have our own app! You can now get the podcast episodes, my amusing updates and most important links straight to your phone. Download it now in the App store or Google Play store. Any feedback about the app will be greatly appreciated!If you enjoyed this podcast, please still subscribe and leave me a rating on Apple or Spotify.Show your support by liking and sharing the podcast with friends and family on social media:FacebookInstagramTwitterYouTubeSubscribe to my newsletter: regenerationstudio.co.uk

Johnn Mendoza is a graduate of BS Biology from Cebu Velez College. Though finishing in BS Biology as a pre-med, he later on ventured into Digital Marketing as a blogger and a Creative strategist for a Digital Agency. Today, his love for Aviculture and Ornithology has led to him pushing an advocacy online to bridge the gap between people who are not familiar with the great biodiversity of our country and the beauty of our natural resources. He is now also an advocate of alternative transport to help preserve the environment.   In this episode, we talk about electric vehicles, ebike haters, getting fit on an ebike, alternative transport as a means of becoming aware of the environment, and birds.   Enjoy!         SHOWNOTES Foreca weather app Same Bike Sugbo Scooteros Baktas Tindak Society + Joel Garganera   Where can you find Johnn? https://www.youtube.com/channel/UCPVxtHe_TV6QeGNTAdI0XRg https://www.youtube.com/channel/UCmIFi-zc56d64dQDwlyC2Xg   This podcast is sponsored by Bix Recovery Supplement. I’ve been using Bix Recovery Supplement as one of the key hydration mixes after a bicycle ride. It’s got all the good stuff in it – vitamin C, Zinc, Vitamin E, Q10, Bromelain, calcium, magnesium, BCAA, potassium, iron and sodium. Learn more and orders yours at https://www.instagram.com/focusrecoveryph Music in the podcast Piano March by Audionautix Support the show: (1) Become a Patreon subscriber – https://www.patreon.com/zerothreetwo (2) Share this episode on social media. More: http://zerothreetwo.com/monday

  Sven Macoy Schmid (Nevz) is a daily live game streamer from the Philippines. Proudly representing #BisayaGaming. I met him through his videography work at the HyveCreative.   In this episode, we talk about opportunities in gaming, why viewers watch streamers, monetizing your gaming, differentiating yourself as a streamer, and moving forward from here.   Enjoy!         SHOWNOTES Gravel Bike Cebu Facebook Group No Boring Days HyveCreative Ride to End Polio video Mineski Alodia Will Dasovich Tier One Rumble Royale Casey Neistat Conan O'Brien   Where can you find Sven? https://www.facebook.com/nevzgaming https://www.youtube.com/user/svenbano14 https://www.instagram.com/svenmacoyschmid/ https://twitter.com/svenmacoyschmid     This podcast is sponsored by Bix Recovery Supplement. I’ve been using Bix Recovery Supplement as one of the key hydration mixes after a bicycle ride. It’s got all the good stuff in it – vitamin C, Zinc, Vitamin E, Q10, Bromelain, calcium, magnesium, BCAA, potassium, iron and sodium. Learn more and orders yours at https://www.instagram.com/focusrecoveryph   Music in the podcast Piano March by Audionautix Support the show: (1) Become a Patreon subscriber – https://www.patreon.com/zerothreetwo (2) Share this episode on social media. More: http://zerothreetwo.com/monday

Nicolo Manreal is synonymous with Rainbowfish Photography. They are one of the big names in the Philippine wedding industry. My wife and I were lucky to have them shoot our wedding. Nicolo and his wife, Matet, founded the studio in 2007. In this episode, we talked about managing a remote team, the challenges of shy creatives, Nicolo's first wedding shoot, the wedding industry today, and going back to basics. Enjoy!             SHOWNOTES Dani Bautista (Zerothreetwo Conversations episode) Dirty Kanza Rae Cabradilla (Zerothreetwo Conversations episode) Matet Gilbey Wild Reverie   Where can you find Nicolo? https://www.instagram.com/rainbowfishphoto/ https://www.facebook.com/rainbowfishphotography https://www.rainbowfishphoto.com/   This podcast is sponsored by Bix Recovery Supplement. I’ve been using Bix Recovery Supplement as one of the key hydration mixes after a bicycle ride. It’s got all the good stuff in it – vitamin C, Zinc, Vitamin E, Q10, Bromelain, calcium, magnesium, BCAA, potassium, iron and sodium. Learn more and orders yours at https://www.instagram.com/focusrecoveryph   This podcast  is also sponsored by Coffiquor. It's a new Cebu-based independent coffee shop and speakeasy. They are currently the only coffee brand offering ready to drink cold brew specialty coffee in 450 ml. Right now they accept orders thru their social media accounts. https://www.instagram.com/coffiquor/   Music in the podcast Piano March by Audionautix Support the show: (1) Become a Patreon subscriber – https://www.patreon.com/zerothreetwo (2) Share this episode on social media. More: http://zerothreetwo.com/monday  

      If you've been a long time listener to the podcast, you might be a little familiar with Kahlil Corazo. He's been on since episode number one of Zerothreetwo Conversations.   I met him a few years ago, we started a mastermind, and I've been learning from him ever since. So I knew this was going to be a good episode.   In this episode, we talked about the Stallion and the Rider, finite and infinite games, roam cult, luck surface area, content, maffetone method and more.   Enjoy!           SHOWNOTES The Stallion and the Rider Thinking Fast and Slow Tim Ferriss Roam research Random Show Obsidian Remnote Gravel Bike Cebu Ave Maldea Ikigai Rick Rubin Mark Sisson Primal endurance Terence Go (Zerothreetwo Conversations episode)     Where can you find Kahlil? https://twitter.com/kcorazo https://twitter.com/Roamfu https://medium.com/@kcorazo   This podcast is sponsored by Bix Recovery Supplement. I’ve been using Bix Recovery Supplement as one of the key hydration mixes after a bicycle ride. It’s got all the good stuff in it – vitamin C, Zinc, Vitamin E, Q10, Bromelain, calcium, magnesium, BCAA, potassium, iron and sodium. Learn more and orders yours at https://www.instagram.com/focusrecoveryph Music in the podcast Piano March by Audionautix Support the show: (1) Become a Patreon subscriber – https://www.patreon.com/zerothreetwo (2) Share this episode on social media. More: http://zerothreetwo.com/monday

When 2020 started, I had plans. Heck! We all had plans. A lot of those plans didn't go the way we wanted them to, but we've found ways to cope.   I talked to Ralph Mangune because he had plans to open up a brick and mortar cafe/bar. He was forced to adapt to the chaos of 2020. Instead of giving up, he pushed through with Coffiquor, started doing online sales, was flexible with their plans, and found ways to let people discover their brand.   In this episode, we talked about starting a business in the heels of a pandemic, cold brews in a can, the challenges of doing business today, and juggling day jobs with a startup.   Enjoy!       SHOWNOTES Nylon Coffee Roasters Meyan Lim-Young (Zerothreetwo Conversations episode) Centro     Where can you find Coffiquor? https://www.facebook.com/Coffiquor https://www.instagram.com/coffiquor/   This podcast is sponsored by Bix Recovery Supplement. I’ve been using Bix Recovery Supplement as one of the key hydration mixes after a bicycle ride. It’s got all the good stuff in it – vitamin C, Zinc, Vitamin E, Q10, Bromelain, calcium, magnesium, BCAA, potassium, iron and sodium. Learn more and orders yours at https://www.instagram.com/focusrecoveryph   Music in the podcast Piano March by Audionautix Support the show: (1) Become a Patreon subscriber – https://www.patreon.com/zerothreetwo (2) Share this episode on social media. More: http://zerothreetwo.com/monday

The pandemic has forced many to rethink their commuting habits, and as a result we've seen a surge of bicycle users all over Cebu. But unfortunately, not all the cities have catered to this new wave of transportation. The streets in Cebu is not what you would call "bike friendly".   I was interested to talk to Daryl because of the work they have been doing to encourage people to bike as a commute, but more importantly, they've been reaching out and talking to people in government and organizations to encourage them to implement bike infrastructure projects.   Daryl Carabio is an architect/urban planner connected with Cebu Holdings Inc./Ayalaland, an advocate for better cities through his work with the Baktas Tindak Society +.   In this episode we talked about why cycling as a commute in Cebu, the implementation of bike lanes in Cebu, what city planning could look like, sustainable development, and how to be a better city.   Enjoy!   SHOWNOTES Imaginary Cycling Network in Cebu City Cebu Leads Foundation Councilor Garganera Pasig Bike Lanes Tindak Kahayag Project   Where can you find Darly? https://www.facebook.com/BaktasTindakPlus   This podcast is sponsored by Bix Recovery Supplement. I've been using Bix Recovery Supplement as one of the key hydration mixes after a bicycle ride. It's got all the good stuff in it - vitamin C, Zinc, Vitamin E, Q10, Bromelain, calcium, magnesium, BCAA, potassium, iron and sodium. Learn more and orders yours at https://www.instagram.com/focusrecoveryph   Music in the podcast Piano March by Audionautix Support the show: (1) Become a Patreon subscriber – https://www.patreon.com/zerothreetwo (2) Share this episode on social media. More: http://zerothreetwo.com/monday

In this episode, we'll be looking at a brief clinical trial looking at coenzyme Q10 (CoQ10, ubiquinone) and its affect on migraines in clinically evaluated migraine sufferers. If CoQ10 works, how much was used? How beneficial is it? Are there caveats? All that and more is covered here. Study: https://www.semanticscholar.org/paper/Efficacy-of-coenzyme-Q10-in-migraine-prophylaxis%3A-A-S%C3%A1ndor-Clemente/a3d4701fc58f7747a1cff3ddcd978a0794a50dc2 Books, Courses, and Hire Me: www.physionic.org YouTube: bit.ly/2JUjXVt Facebook: bit.ly/2PlIOaB Instagram: bit.ly/2OBFe7i Email List: bit.ly/2AXIzK6

訂閱東森美洲電視頻道→https://bit.ly/2VF6dFI 主持：曾國城、蔡尚樺 (00:00)Q1：哪家電影公司LOGO是咆哮的雄獅，且是美國電影象徵？ (02:56)Q2：哪種國標舞蹈，在比賽時舞者通常不會有笑容？ (05:01)Q3：國標舞的阿拉丁舞比賽中，比賽中不會跳哪種舞？ (06:58)Q4：芭蕾舞起初是那些人開始跳？ (08:33)Q5：倫巴最早是哪種人發明？ (09:57)Q6：哪位藝術家是在80歲還在結婚的藝術家？ (11:31)Q7：世上最貴的名畫排行，最貴名畫是誰的作品？ (13:04)Q8：哪個藝術家參與過棒棒糖的發明，並設計外包裝？ (14:14)Q9：哪個國家禁止芭比娃娃商品販售？ (16:26)Q10：獅子王是莎士比亞四大悲劇的哪部做為創作藍本？ (17:34)Q11：迪士尼公主中，哪一位公主是以真人為原型？ (19:29)Q12：哪種動物是迪士尼最早成名發展周邊商品的明星卡通？ (21:10)Q13：宮崎駿哪部電影票房最高？ (22:59)Q14：「跑龍套」的稱呼最早這個詞和演員的關係是什麼？ (24:53)Q15：第一個樂高人偶是什麼職業？ (26:04)Q16：當初歐洲人彩繪指甲的原因是什麼？ (28:37)Q17：世界歷史中，在位最久的君王是誰？ (30:29)Q18：哪件事可以提升唱歌音感？ (32:58)Q19：拉拉熊和小雞的的關係是什麼？ (33:42)Q20：電玩「馬力歐」名字是任天堂的誰而命名？ --- Send in a voice message: https://anchor.fm/ettvamerica/message

You guys had so many awesome questions and we didn’t get to nearly all of them last week so we are back again this week to answer more!! We’re wide open books over here!    Show Notes:   04:05 - Q1 - Will you be doing a homebirth for your future pregnancies? 09:44 - Q2 - What’s going on with your sex life?   13:52 - Q3 - Jamie, what is your last name? Is it Otis or Hehner? 16:21 - Q4 - Do you stay in touch with your MAFS fam?  16:50 - Q5 - Is Hendrix tongue tied? 18:09 - Q6 - Jamie, why do you call Henley, Gracie?  20:13 - Q7 - Are you letting your family hold or touch the kids yet? 22:44 - Q8 - Update on Jamie’s biopsy? 23:10 - Q9 - How is Henley’s potty training going? 25:26 - Q10 & Q11 - Jamie, when did you realize that the experts were correct and you were in love with Doug?  28:50 - Q12 - Why did you change Hendrix’s name from Hayes to Hendrix?  32:43 - Next week we have two ladies from the Instagram account, Big Little Feelings! They are literally Jamie’s toddler Bible!!! They will be sharing different parenting tips, especially navigating toddler life!   Wash your hands and wear your masks! Learn more about your ad choices. Visit megaphone.fm/adchoices

The best ways to maintain or boost your energy levels is to eat a well, balanced diet, exercise regularly, and get enough sleep. But these are not always easy to achieve as you would need to balance with the demands of life. This is one of the reasons why you may not accomplish everything on your task list, and you may sometimes find it hard to even get out of bed. But luckily for you, there are some supplements and herbs that help to increase energy.   At our chiropractic office, Elizabeth City, NC, we encourage some of these supplements and herbs to people who need support in their energy levels throughout the day.   So if you want to perk yourself up to achieve more daily, you can try out these supplements and herbs below:   Ashwagandha - Ashwagandha is one of the most useful medicinal herbs in Indian for over 3,000 years. This herb helps to enhance the body’s resilience to mental and physical stress, thereby boosting energy levels.  More so, numerous studies have shown that the ashwagandha root is effective in reducing anxiety and stress. It also helps to reduce the fatigue associated with exercising.   Maca - Maca is rich in nutrients that provide the body with energy-boosting benefits. It also helps you adapt to various environmental stressors, as well as improve your mood and endurance.  Also, the maca is safe with no adverse reactions or side effects. However, it is best to consume the gelatinized maca over the raw maca, due to the chemical substance called goitrogens, which is present in this herb and can affect your iodine levels.   CoQ10 - CoQ10 stands for coenzyme Q10 and it is found naturally in the body as ubiquinol and ubiquinone. The body cells use CoQ10 to produce energy and prevent oxidative damage. However, when the level of CoQ10 declines in your body due to age, heart failure, type-2 diabetes, or certain cancers, your cells may not produce the needed amount of energy anymore, and this may lead to fatigue.  Hence, taking CoQ10 supplements is an effective solution to help increase your energy level and reduce fatigue.   Vitamin B12 - Vitamin B12 is essential for transforming food into energy that the cells can use. It also helps to keep your blood cells and nerves healthy to prevent a type of anemia that can make you weak.  You can get vitamin B12 naturally from animal proteins like fish, meat, and dairy products. However, you may be at risk of vitamin B12 deficiency if your body is not getting enough or is unable to absorb the needed amount. This is common among vegans, older adults, and those with G1 disorders.  But, you can boost your energy levels by taking vitamin B12 supplements. This helps to ward off fatigue and weakness.   Creatine - Creatine is a donor of phosphate to Adenosine diphosphate to produce adenosine triphosphate (ATP) - which is the energy currency of life. You can include creatine supplements in your diet to when your body needs a quick source of energy for high-intensity, short-duration exercises like jumping, football, short sprints, or weightlifting. When you supplement with creatine, you get enough energy to train harder and longer.   Other supplements and herbs that help to increase energy levels include: Beetroot powder Iron Rhodiola Rosea Citrulline Tyrosine Melatonin Holy Basil Ginseng   You can experience reduced energy levels as you go about your daily routines and eating good and exercising may not be enough to keep your energy fired-up. Hence, you can take the supplements and herbs listed above to enjoy increased energy levels and improve your overall wellbeing.   However, it is important to note that things like body pain, headache, and stiffness can zap you of the available energy needed by your body to function optimally. But you can take care of that by getting the best chiropractic care. You can consult Dr. Jason Jones at our Chiropractic Office, Elizabeth City, NC to get the best care to eliminate these troubles to keep your energy levels up as you enjoy your choice of supplement and herbs.                                                                                                                        

You guys have lots of questions for us and we are answering all the things! We are excited for you to get to know us more :) And Hendrix is podcasting with us this week!   AND! You guys had so many awesome questions that we didn’t get to them all, so there will definitely be a part 2 in the very near future!   Show Notes: 03:20 - Jamie shares that Hendrix is officially 1 month old! He weighs 12 lbs and 6.5 oz! Big Boy! 05:53 - Jamie talks about how Doug sleeps like a dead person!  07:29 - Q1 - How did you deal with anxiety in early pregnancy? 10:24 - Q2 - Do you want more kids? If so, WHEN will you start trying? How old will Hendrix be when you start trying again? 12:01 - Q3 - Is there an update on the Florida house/moving down there? 13:21 - Q4 - How do you keep the romance alive and have things changed in that department going from 1 kid to 2? 14:54 - Q5 - Any tips for having a homebirth? Things you’d do differently or advice you have? 24:06 - Q6 - When will you start having sex again and what is is like having mismatched libidos? Any advice on having sex after having a kid? 27:09 - Q7 - How has Henley been now that she is a big sissy? Is she reacting well to the change? 30:22 - Q8 - Has a second baby strengthened your marriage? 32:12 - Q9 - Have you been to South Africa? What are other places you want to travel to? 34:08 - Q10 - How do you feel about MAFS now? Do you feel some people are just doing it for fame?   More to come! Stay well, you guys!   And thank you to our sponsors: Nutrafol - You can grow thicker, healthier hair by going to Nutrafol.com and use promo code HMCP to get 20% OFF - this is their best offer available ANYWHERE! Plus free shipping on EVERY order! Warby Parker - Go to warbyparker.com/hotmarriage and try Warby Parker’s free Home Try-On program! Order 5 pairs of glasses to try at home for free for 5 days – there’s no obligation to buy! Ships free and includes a pre-paid return shipping label.

No podcast QUARENTENADOS desta semana, foi a vez do Dudu Sales, do Papo de Gordo, comparecer ao nosso exercício semanal de saúde mental! Continue lendo em: Dudu Sales – QUARENTENADOS