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This week's EYE ON NPI is loud and proud - it's the Diodes Incorporated PAM8019E Class-D Audio Amplifier and Headphone Driver (https://www.digikey.com/en/product-highlight/d/diodes/pam8019e-class-d-audio-amplifiers), a combo audio amplifier that will add high quality analog audio output to your next design without breaking the bank. We've stocked and used the PAM series of audio amplifiers for over a decade, one of our best sellers is the PAM8302 (https://www.adafruit.com/product/2130) breakout which is a monophonic class D amp for basic projects. Things we like about it: its very inexpensive, it's rock solid, 3~5V power, hard to 'pop' and can drive 4~8 ohm output. But it's only one channel and we often get asked if we can stock a stereo Class D. Also, it's pretty common for us to get requests for headphone drivers. The PAM8019E (https://www.digikey.com/short/b3r00dw5) can do both, and has a lot of nice little details. First up, this is an analog in/out amplifier - no PDM or I2S or TDM. So this is good for either all-analog setups or when you have already converted your digital audio to 'line level', about 1Vpp. Since it's stereo out, there's also stereo input: don't worry about DC bias because you can couple in with 1uF and it will internally bias to half-VDD. Unlike the PAM8302 (https://www.digikey.com/en/products/detail/diodes-incorporated/PAM8302AASCR/4033281), this isn't differential input, reference is ground. You can use either the Headphone amp or Speaker amp, but not both: the selection is done with with a digital input pin which will do a smooth pop-free hand off. For the outputs, there's the stereo Class D outputs. These come as two tied-load bridges (https://en.wikipedia.org/wiki/Bridged_and_paralleled_amplifiers#Bridged_amplifier) which means you can just tie the two sides of each speaker to positive/negative without any capacitors. Class D is an efficient amplification architecture (https://en.wikipedia.org/wiki/Class-D_amplifier) and if done at a high enough frequency - in this case around 400KHz - the inductive load of the speaker acts as a filter so no separate RLC is required. For EMI purposes, the datasheet recommends a simple 100MHz 600ohm ferrite bead plus 1uF capacitor just to reduce the sharp square waves. For headphone, the chip uses a Class AB (https://en.wikipedia.org/wiki/Power_amplifier_classes#Class_AB). These are going to give cleaner output because there's no intermediate PWM stage: speakers tend not to be good enough to notice the hiss added from Class D, but headphones are much more sensitive. Also, at the ~50mW output we're talking about, there's not a lot of benefit to optimizing power. Since headphones are by design 'single ended', you will need 220uF caps on the output for high-pass filtering. Some modern audio amps have a 'floating' ground generated to sink the current for cap-less output but these tend to be more expensive and also wouldn't be compatible with line-level inputs. Some nice details we like to see in an amp, especially one this affordable: spread-spectrum so the high frequency PWM isn't centered on one spike, undervoltage-lockout, short-circuit on all outputs, pop-free, non-clip power limiting and separate not-in-line audio level selection. The last one is particularly nice because on the PAM8302 we have to put an analog rheostat in-line with the input pins to reduce the gain from 15x down to 1x or 2x. This would require a stereo pot, which can get scratchy and fail over time. On the PAM8019E (https://www.digikey.com/short/b3r00dw5), the gain is set with a DC voltage which means you can set it with a potentiometer or a DAC output, and you don't have to worry about jitter or scratchiness because there's hysteresis over 64 points. We've already ordered 10 pieces of the Diodes Inc PAM8019E (https://www.digikey.com/short/b3r00dw5) to design a breakout. DigiKey has tons in stock so we recommend you buy some too, at 34 cents a-piece, at reel quantity, it's hard to say no! They're available in 3x3mm or 4x4mm package sizes, both are QFN-20. Order today and you can be bumpin' and boppin' with either speakers or headphones by tomorrow. afternoon.
Diese Folge zum Thema Fett haben sich einige Zuhörer:innen gewünscht, weswegen wir dem sehr gerne nachkommen. :-) Für das Thema haben wir uns die perfekte Interviewpartnerin geholt, denn Ihr lernt diesmal Gina Kümmel kennen. Gina ist Diätassistentin, zertifizierte Ernährungsberaterin/VDD & Studentin an der Dualen Hochschule für Prävention und Gesundheit. Außerdem bereichert Gina unser Team in Bergisch Gladbach mit Ihrer Herzlichkeit, Professionalität und guten Laune! :-) Gina hat sich in der letzten Zeit ganz besonders damit beschäftigt, inwieweit gesunde Fette beim Abnehmen helfen können bzw. warum komplette "low-fat Diäten“ ein Problem darstellen. Die folgenden Punkte besprechen wir: - Wie können wir gute und schlechte Fette unterscheiden? - Sind gesättigte Fettsäuren wie Milch, Eier und Fleisch wirklich so schlecht wie ihr Ruf? - Welche Fette helfen uns ganz besonders beim Abnehmen? - Worauf sollten wir in der Küchen und bei Einsatz von Fetten und Ölen achten? - Von welchen Ölen raten wir ab? Wir wünschen Dir ganz viel Spaß bei dieser neuen Folge! -- Wenn Du Frau bist und das Gefühl hast, Du leidest unter einer Schilddrüsenunterfunktion oder Du glaubst, dass Hormone generell schuld an Deiner Gewichtszunahme sind, dann melde Dich gerne bei unserem kostenfreien Hormon Balance Workshop an. Dieser findet am Sonntag, den 25. August um 10 Uhr in zoom statt. Eine Aufzeichnung wird im Anschluss an alle Teilnehmer verschickt. Hier geht es zur Anmeldung: https://42e86234.sibforms.com/serve/MUIFAGHXkDsFC5e6tgc5HYLplEQzj7vn6Yj7kmDejVxMY7syhHOp7-ME_Y3Rurk9nqaumtEW5Z2Q0SsXfd1Q-DaM7IDNBa-nKeuOErgJm5pZw2OqLJ4IYORaSGMRsopKEt3EhnrgqjVQXXIY7YsrU88mkYhd7_X9N3GYBXfQGnDMAOXFBQGMTC2h-Olf7keAqud-YW0V4tZwc9Qt Wir freuen uns sehr, wenn Du dabei bist! _ Wenn Du noch mehr über uns erfahren möchtest, dann schau' doch mal hier vorbei: - Unsere Webseite: www.si-ernaehrungsinstitut.de - Instagram: @si_ernaehrungsinstitut - Oder schreib' uns direkt per E-mail an: ich-kann-abnehmen@si-ernaehrungsinstitut.de Alles Liebe Isabell & Volker
In dieser Podcastfolge haben hat Lea ganz viele Stimmen von Diätassiesten*innen auf dem VDD-Kongress (Verband der Diätassistenten) eingefangen. Um sie zu Fragen; Wo arbeiten Ihr als Diätassistentinnen und was ist euer Highlight im Beruf? Den inspiration für den Beruf tut jemden gut, egal ob Berufseinsteigerin oder Berufserfahrene*r. Natürlich geben Merle und Lea auch Ihr Highlights vom VDD wieder. So erreicht ihr uns: Instagram: https://www.instagram.com/dietyourbrain/ Facebook: https://www.facebook.com/dietyourbrain E-Mail: dietyourbrain@web.de
De PVV van Geert Wilders heeft de verkiezingen gewonnen en vierde dag vandaag uitbundig, in een fractievergadering met twee keer zoveel mensen als de vorige. De partij verdubbelt, naar wat vooralsnog lijkt op 37 zetels. Bij de fractiekamers van GroenLinks-PvdA en de VDD hing een minder gelaten sfeer. Politiek verslaggevers Leendert Beekman en Mats Akkerman haalden de reacties op. See omnystudio.com/listener for privacy information.
This week's EYE ON NPI is switching it up, with a look at some high-voltage-capable analog switches - Texas Instruments' TMUX821x Flat RON SPST 4-Channel Switches (https://www.digikey.com/en/product-highlight/t/texas-instruments/tmux821x-flat-ron-spst-4-channel-switches). A simple and effective way to switch and control up to 4 x 100V connections with up to 200mA each from any microcontroller or microcomputer. We carry dozens of different switches (https://www.adafruit.com/category/759), and DigiKey stocks easily 50K different switch configurations (https://www.digikey.com/en/products/result?s=N4IgTCBcDaIM4HcCWAXAxgCxAXQL5A0) from push-buttons (https://www.digikey.com/en/products/filter/pushbutton-switches/199) to toggles (https://www.digikey.com/en/products/filter/toggle-switches/201) but all of these require a person to push the button mechanically, whereas the TMUX series will connect and disconnect based on a separate digital signal, as low as 1.8V and as high as 48V. These are often used for switch audio or video, but are also often used in sensor measurement or test equipment. They're not good for power supply switching, and for digital signals there's often other ways of moving signals around, although they are sometimes used for the data lines of bidirectional digital signaling systems like USB. Like mechanical switches, the TI TMUX family of analog switches are 'bidirectional' (https://www.youtube.com/watch?v=z9GRiYPq7LM) - that means you can pass signal from A to B or from B to A. However, unlike mechanical switches there is no, well, mechanical connection. Instead, the switches are created by putting an N-FET and P-FET back-to-back. This means that there is no switch-bounce (https://en.wikipedia.org/wiki/Switch#Contact_bounce) or contact oxidation (https://en.wikipedia.org/wiki/Electrical_contact). Analog switches are pretty magical, and solve design problems that involve moving an analog signal around without having to hand-build a switch on board, but there are a few things to watch out for when 'modeling' how an analog switch varies from a mechanical one! First up, analog switches have fairly low 'Ron' resistance when the analog switch connection is made - on the order of a few ohms - and that is much higher than a mechanical switch. There is also 'very very high resistance, but not an open-circuit' when the analog switch connection is broken - on the order of a few hundred mega-ohms. (https://www.youtube.com/watch?v=n9EklrCrgH8) And don't forget you will need to have positive and negative power supplies beyond the voltages switched. So, if you are trying to switch 24Vpp signal, that ranges from -12V to +12V, you will need to supply them on the VDD and VSS lines. Also these are not electrically isolated, so add a separate opto/digital isolation (https://www.ti.com/isolation/digital-isolators/overview.html) circuitry if you want to keep your microcontroller fully disconnected from any high voltages. But compared to classic jellybean analog switches like the CD4066 ,(https://www.digikey.com/short/jw44n87t) the TI TMUX series of analog switches have improved circuit protections that will keep you from popping your chips (https://www.youtube.com/watch?v=RTPHjhjUl0E) by accident - especially since this series can be used with up to 100V. Check the datasheet for all details, but highlights include: built in pull-down resistors, protection against over/undervoltage as well as out-of-order voltage application, and latch-up immunity. If you're looking to switch up some analog signals on your next design, check out the Texas Instruments' TMUX821x 4-Channel Analog Switch (https://www.digikey.com/short/r3rhn270) family with 3 different configurations of NO/NC. And all are in stock for immediate shipment from DigiKey! Order tonight and by tomorrow morning you will be switchin' and swatchin' with these low Ron SPST analog switches.
In unserer nächsten Podcastfolge von Diet your Brain geht es um die praktische Umsetzung einer nachhaltigen Ernährung. Wir haben Jörg Schmid von KLUG (Deutsche Allianz Klimawandel und Gesundheit e.V.) zu Gast, einen Spezialisten auf diesem Gebiet, der uns Tipps und Tricks gibt, wie wir unsere Ernährung nachhaltiger gestalten können. In der vorherigen Folge haben wir bereits die Hintergründe zur nachhaltigen Ernährung besprochen. Jetzt geht es um die praktische Umsetzung im Alltag. Seid dabei und lasst uns gemeinsam etwas für unsere Umwelt tun! Literaturempfehlungen: ⁃ The EAT-Lancet Commission on Food, Planet, Health: https://eatforum.org/eat-lancet-commission/ ⁃ VeChi-Youth-Studie (Studie über die Ernährungsgewohnheiten von Kindern & JUgendlichen): https://www.vechi-youth-studie.de ⁃ Nico Rittenau (Ernährungswissenschaftler): https://www.nikorittenau.com ⁃ Sebastian Copien (veganer Profikoch): https://www.sebastian-copien.de ⁃ Planetary Health Academy (tolles Bildungsangebot zum Thema Planetary Health): https://planetary-health-academy.de ⁃ Artikel über die Zusammenarbeit vom VDD und KLUG: https://www.klimawandel-gesundheit.de/neues-projekt-mit-diaetassistentinnen/ ⁃ VDD Kongress (KLUG stellt gemeinsames Projekt vor. Samstag, den 06.Mai, Session 4, 10:15 Uhr – 10:30 Uhr. Im Nachgang auch on-demand erreichbar): https://vdd-bundeskongress-digital.de
Interview mit Jörg Schmid von KLUG (Deutsche Allianz Klimawandel und Gesundheit e.V.): Nachhaltige Ernährung für Diätassistenten Als Diätassistent*innen wissen wir, wie wichtig eine ausgewogene Ernährung für unsere Gesundheit ist. Aber hast du schon mal darüber nachgedacht, wie deine Ernährung auch die Umwelt beeinflusst? In unserer neuesten Podcastfolge von Diet your Brain sprechen wir mit Jörg, einem Experten für nachhaltige Ernährung, über dieses wichtige Thema. Wir erfahren, welche Lebensmittel wir wählen sollten, um die Umweltbelastung zu reduzieren, wie wir Lebensmittelverschwendung vermeiden können und wie wir unsere Patienten über nachhaltige Ernährung aufklären können. Als Experten für Ernährung haben wir eine Verantwortung, uns für eine nachhaltige Ernährung einzusetzen und unsere Patienten darüber zu informieren. Hört rein und erfahrt mehr! Literaturempfehlungen: ⁃ The EAT-Lancet Commission on Food, Planet, Health: https://eatforum.org/eat-lancet-commission/ ⁃ VeChi-Youth-Studie (Studie über die Ernährungsgewohnheiten von Kindern & JUgendlichen): https://www.vechi-youth-studie.de ⁃ Nico Rittenau (Ernährungswissenschaftler): https://www.nikorittenau.com ⁃ Sebastian Copien (veganer Profikoch): https://www.sebastian-copien.de ⁃ Planetary Health Academy (tolles Bildungsangebot zum Thema Planetary Health): https://planetary-health-academy.de ⁃ Artikel über die Zusammenarbeit vom VDD und KLUG: https://www.klimawandel-gesundheit.de/neues-projekt-mit-diaetassistentinnen/ ⁃ VDD Kongress (KLUG stellt gemeinsames Projekt vor. Samstag, den 06.Mai, Session 4, 10:15 Uhr – 10:30 Uhr. Im Nachgang auch on-demand erreichbar): https://vdd-bundeskongress-digital.de
Une Cession Presque Parfaite : Dans les coulisses de la transmission d'entreprises
Dans ce nouvel épisode j'ai eu le grand plaisir de recevoir Jérome Casteuble, associé au sein du Groupe Concorde qui va nous parler de l'objectif d'une Vendor Due Dilligence et des retraitements à effectuer dans le cadre de la valorisation de l'entreprise. Parce que oui quand on vend sa boite, il y a le grand sujet de la valorisation et quand on parle valo on parle de retraitements à faire. Et pourquoi prendre le risque d'avoir de mauvaises surprises et de voir sa valorisation baisser ou le deal échouer quand on peut anticiper ce sujet et s'entourer de professionnels ? Alors, concrètement, c'est quoi des retraitements et surtout, qu'est-ce qu'on retraite ? Vous le découvrirez dans cet échange durant lequel Jérome a évoqué : Son parcours professionnel et son rôle dans le cadre d'une cession d'entreprise Ce qu'est une Vendor Due Dilligence et ses objectifs Les éléments pris en compte dans la réalisation d'une VDD La valorisation d'entreprise, ce qu'on regarde, ce qu'on retraite Les retraitements sur l'EBITDA, EBIT, BFR, Trésorerie et endettement net.. Les retraitements sur le Factor, l'IFRS16 Les retraitements sur les aides de l'Etat (PGE, OR..) Les points d'attention et les erreurs à éviter dans la valorisation et les retraitements pour éviter les mauvaises surprises (par ex le retraitement sur le Factor qui peut être couteux) Les conseils pour un dirigeant qui envisage de vendre Enfin bref, un très bel échange avec Jérome qui montre l'importance d'anticiper tous ses aspects pouvant impacter la valorisation et donc le prix de cession !
Terwijl een VVD-minister nog niet eens een jaar geleden in de Ridderzaal excuses aanbood aan de transgemeenschap voor wetten uit het verleden, struikelen dezelfde vier regeringspartijen nu plots over hetzelfde thema. De VVD maakte deze week een plotselinge ommezwaai tijdens het debat over de nieuwe transgenderwet. Het linkse blok was verbaasd, het CDA probeerde zich ondertussen te profileren als bruggenbouwer, en D66 oogt vooral verloren. Wat doet de VVD? De VVD lijkt intern bezig een balans te vinden tussen individuele vrijheden enerzijds, en het doorslaan van ‘woke' anderzijds, zoals VVD-minister Yesilgöz (justitie) onlangs zei. Of is dit hun manier gehoor te geven aan het geklaag van de achterban dat er tijdens de formatie te veel is weggegeven aan coalitiepartner D66? In deze aflevering van Haags Halfuurtje blikken Christoph Schmidt en politiek verslaggever Wilma Kieskamp terug op het onstuimige debat. De nieuwe transgenderwet valt dan volgens Kieskamp niet in de categorie ‘medische ethiek' - de klassieke links-rechts verdeling in de Kamer doet er wel aan denken. Lees ook: Door forse kritiek van de VVD zal de transgenderwet het alleen in aangepaste vorm redden Wat is eigenlijk die deskundigenverklaring voor transgenders, die het wetsvoorstel wil schrappen? Minister Yesilgöz ziet in wokisme en wantrouwen een gevaar voor de democratie Presentatie: Christoph Schmidt; Redactie en productie: Hannah van der Wurff en Joris Belgers; deze week te gast: Wilma Kieskamp.Support the show: http://www.trouw.nlSee omnystudio.com/listener for privacy information.
The Gary Null Show Notes – 08.25.21 American Medical Association Calls for Covid-19 Vaccine Mandates China, 2049 The Leak That ‘Exposed the True Afghan War' Fauci Dismisses “Freedom” In Call For Vaccine Mandates: “The Time Has Come. Enough Is Enough.” A New Low for the FDA Eight Key Points on America's Defeat in Afghanistan 2 Things Mainstream Media Didn't Tell You About FDA's Approval of Pfizer Vaccine America in an Age of Faucism Today's Videos 1. Dave Cullen Video on Mandating Vaccines: ” Vaccination: They're Becoming Desperate” 2. The Dunning-Kruger Effect – Cognitive Bias – Why Incompetent People Think They Are Competent 3. Dr. Malone Sounds Alarm On Liability Coverage Of Pfizer Vax Start this clip at 5.00 in when Dr. Malone begins to speak. 4. Dr. Ryan Cole #StoptheMandate (start at 1:25) Study suggests vitamin D supplementation may serve as part of strategy for autoimmune and infectious diseases associated with leaky gut MacKay Children's Hospital (Taiwan), August 15, 2021 According to news reporting from Taipei, Taiwan, research stated, “Vitamin D (VD) plays an important role not only in mineral balance and skeletal maintenance but also in immune modulation. VD status was found correlated with the pathophysiology and severity of inflammatory bowel diseases and other autoimmune disorders. Epithelial barrier function is primarily regulated by the tight-junction (TJ) proteins.” The news reporters obtained a quote from the research from MacKay Children's Hospital: “In this study, we try to establish an animal model by raising mice fed VD-deficient diet and to investigate the effects of VD-deficient diet on gut integrity and zonulin expression. Male C57BL/6 mice were administered either VD-deficient [VDD group, 25(OH)2D3 0 IU/per mouse] or VD-sufficient [VDS group, 25(OH)2D3 37.8 IU/per mouse] special diets for 7 weeks. Body weight and diet intake were recorded weekly. Serum VD levels were detected. After sacrifice, jejunum and colon specimens were collected. The villus length and crypt depth of the jejunum as well as mucosa thickness of the colon were measured. Various serum pro-inflammatory cytokines and intestinal TJ proteins were assessed. The serum level of zonulin and the mRNA expression of jejunum zonulin were also investigated. We found that mice fed a VDD diet had a lower serum level of VD after 7 weeks (p < 0.001). VDD mice gained significant less weight (p = 0.022) and took a similar amount of diet (p = 0.398) when compared to mice raised on a VDS diet. Significantly decreased colon mucosa thickness was found in VDD mice compared with the VDS group (p = 0.022). A marked increase in serum pro-inflammatory cytokine levels was demonstrated in VDD mice. All relative levels of claudin (CLD)-1 (p = 0.007), CLD-3 (p < 0.001), CLD-7 (p < 0.001), and zonulin-1 (ZO-1, p = 0.038) protein expressions were significantly decreased in the VDD group when compared to the VDS group. A significant upregulation of mRNA expression of jejunum zonulin (p = 0.043) and elevated serum zonulin (p = 0.001) were found in the VDD group.” According to the news editors, the research concluded: “We successfully demonstrated that VDD could lead to impaired barrier properties. We assume that sufficient VD could maintain intestinal epithelial integrity and prevent mucosal barrier dysfunction. VD supplementation may serve as part of a therapeutic strategy for human autoimmune and infectious diseases with intestinal barrier dysfunction (leaky gut) in the future. To our knowledge, this is the first study to demonstrate that VDD could lead to a significant upregulation in mRNA expression of the jejunum zonulin level and also a marked elevation of serum zonulin in a mouse model.” Investigating the anti-hypertensive effects of pumpkin seed oil Marymount University (US) and University of Guilan (China), August 24, 2021 In a study, researchers from Iran and the U.S. found that pumpkin seed oil can potentially treat hypertension in postmenopausal women. Their report was published in Complementary Therapies in Clinical Practice. Postmenopausal women are more likely to develop hypertension than men of the same age. In vivo studies reveal that pumpkin seed oil has anti-hypertensive activity. The team investigated the effects of pumpkin seed oil supplementation on vascular function and heart rate variability in postmenopausal women with elevated blood pressure. Participants were assigned to take either a pumpkin seed oil supplement or a placebo for the six-week study. Those in the experimental group took 3 grams of pumpkin seed oil every day. Brachial and central blood pressure, wave reflection (augmentation index, AIx), arterial stiffness (SI) and various HRV parameters were measured at baseline and at the end of the study. Those who took pumpkin seed oil had significantly lower AIx, brachial and systolic blood pressure after treatment. SI and HRV parameters remained unchanged for the treatment group and the placebo group at the end of the study. In sum, taking pumpkin seed oil may improve arterial hemodynamics in postmenopausal women. Lack of exercise and poor nutrition could increase the risk of diseases like dementia Kings College London, August 23, 2021 New research from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King's College London has found that both diet and exercise can influence the risk of cognitive decline (CD) and dementia by potentially influencing hippocampal neurogenesis (the process by which the brain produces new brain cells) long before their onset. The study, published in Alzheimer's & Dementia: The Journal of the Alzheimer's Association, suggests that altered neurogenesis in the brain could potentially represent an early biomarker for both CD and dementia. The investigation studied how the blood of participants with and without CD and dementia could influence hippocampal neurogenesis in laboratory settings and whether diet and exercise were important factors. Specifically, blood samples of 418 French adults over the age of 65 were collected 12-years prior to CD and dementia diagnosis and tested on human hippocampal stems cells. Additionally, information on each participant's sociodemographic, lifestyle, and clinical data were collected and incidence cognition status and dementia were measured every two to three years over a 12-year period. Over the course of the study, the researchers established that 12 years prior to diagnosis, both CD and Alzheimer's were associated with levels of neural stem cell death. The team also found that exercise, nutrition, vitamin D levels, carotenoid and lipid levels are all associated with the rate at which cells die off. Furthermore, physical activity and nutrition were key factors that then also determined CD status. Specifically, researchers found that reduced physical activity and increased malnutrition both increased cell death which in turn increased the risk for future CD. While previous studies have established that diet and exercise have some protective effects against CD and dementia, these roles have been poorly understood at the neurobiological level. To date, studies on animals have shown how diet and exercise can directly influence hippocampal neurogenesis, potentially explaining how exercise and diet may biologically exert their effects, but this study sheds further light on this in the context of a human model. Dr. Sandrine Thuret, the study's lead investigator said, “Our study has demonstrated not only that there are individual markers of hippocampal neurogenesis associated with CD and dementia 12 years later, but also that there is some degree of specificity with respect to diagnoses of dementia subtypes. If an individual displays an increase in their levels of cell death during differentiation (when neural stem cells are becoming neurons), we can look at this as a potential warning sign of CD. Conversely, a decrease in levels of cell death during proliferation (the process by which a single cell divides into a pair) and reduced hippocampal progenitor cell integrity could be viewed as a predictor for Alzheimer's Disease and Vascular dementia, respectively.” According to Alzheimer's Research UK, there were a total of 525,315 people living with a dementia diagnosis in the UK in 2020. Rates of cognitive decline and dementia are expected to triple in prevalence by 2040. Dr. Andrea du Preez, the study's first author from King's IoPPN said, “While more work is undoubtedly needed to fully understand how diet and exercise might modulate hippocampal neurogenesis, our findings may represent an effective early preventative strategy against CD and dementia.” Mindfulness may improve cognition in older adults University College London, August 23, 2021 Mindfulness may provide modest benefits to cognition, particularly among older adults, finds a new review of evidence led by UCL researchers. The systematic review and meta-analysis, published in Neuropsychology Review, found that, while mindfulness is typically geared towards improving mental health and well-being, it may also provide additional benefits to brain health. The study's lead author, PhD student Tim Whitfield (UCL Psychiatry) said that “the positive effects of mindfulness-based programs on mental health are already relatively well-established. Here, our findings suggest that a small benefit is also conferred to cognition, at least among older adults.” The researchers reviewed previously published studies of mindfulness, and identified 45 studies that fit their criteria, which incorporated a total of 2,238 study participants. Each study tested the effects of a mindfulness-based intervention delivered by a facilitator in a group setting, over at least four sessions, while excluding mindfulness retreats in order to have a more homogenous set of studies. The majority of studies involved a certified instructor teaching participants techniques such as sitting meditation, mindful movement and body scan, generally on a weekly basis across six to 12 weeks, while also asking participants to continue the practices in their own time. The researchers found that overall, mindfulness conferred a small but significant benefit to cognition. Subgroup analysis revealed that the effect was slightly stronger for people over 60, while there was not a significant effect for people under 60. Tim Whitfield commented that “executive function is known to decline with age among older adults; the improvement in people over 60 suggests that mindfulness may help guard against cognitive decline, by helping to maintain or restore executive function in late adulthood. It might be easier to restore cognitive functions to previous levels, rather than to improve them beyond the developmental peak.” When they investigated which aspects of cognition were affected, the researchers found that mindfulness was beneficial only to executive function, and more specifically, there was strong evidence of a small positive effect on working memory (which is one facet of executive function). The researchers also analyzed whether mindfulness outperformed other ‘active interventions' (such as brain training, relaxation, or other health or educational programs) or only when compared to people who were not offered any alternative treatment. They found that cognitive benefits of mindfulness were only significant compared with an ‘inactive' comparison, which means they cannot rule out that the benefits may have been at least partly derived from an expectation of treatment benefits, or social interactions. The researchers say that more research is needed into which characteristics of mindfulness training may be more likely to confer cognitive benefits, or whether delivering interventions over longer periods, or in intensive retreat settings, might yield greater cognitive benefits. Senior author Dr Natalie Marchant (UCL Psychiatry) said that they “know mindfulness-based programs benefit mental health, and our paper now suggests that mindfulness may also help to maintain cognitive faculties as people age. Mindfulness practices do not share much in common with cognitive test measures, so it is notable that mindfulness training's impact appears to transfer to other domains. While our review only identified a small benefit to executive function, it remains possible that some types of mindfulness training might deliver larger gains.” Major Depression Symptoms Improved with Chlorella University of Western Australia, August 23rd 2021 The symptoms of depression are often treated with drugs that can have long-term adverse side effects. A new study finds chlorella significantly reduces symptoms of major depression. Research from the University of Western Australia in Perth has found that chlorella can significantly improve symptoms of depression. The researchers tested 92 patients with major depressive disorder – a disorder that affects millions of people around the world. The researchers split the patients into two groups. They gave 42 of the patients 1,800 milligrams of Chlorella vulgaris extract per day. The other 50 patients continued their standard care. The researchers used a scale called the Hospital Anxiety and Depression Scale (HADS) to test the patients' symptoms of depression, along with the Beck Depression Inventory II (BDI-II) scale. Both of these have been used in clinical settings to establish the range of depressive symptoms and the severity of the diagnosis. After six weeks of treatment with either the standard pharmaceutical treatment or chlorella extract, the researchers found that those patients who had taken the chlorella had significantly reduced scores in both depression tests. The BDI-II scores went down by over four points and the HADS scores went down by 3.71 points. To give some reference, the HADS scale consists of 21 points, and anything over an 8 is considered symptomatic of anxiety or depression. In addition to reduced total scores, the researchers also saw significant reductions in some of the subset scores. For example, physical and cognitive symptoms were significantly improved in the chlorella group, and subscales for depression and anxiety were significantly lower among the chlorella group. The researchers concluded: “This pilot exploratory trial provides the first clinical evidence on the efficacy and safety of adjunctive therapy with CVE in improving physical and cognitive symptoms of depression as well as anxiety symptoms in patients who are receiving standard antidepressant therapy.” Chlorella is a microalga. It is a single-celled algae that is typically grown in controlled growth medium tanks. It is significantly high in protein, with over 40 percent protein, with all of the essential amino acids. It also contains proteins that stimulate growth hormone and brain neurotransmitters. Concentrated extract was used in this study due to the fact that whole chlorella can be difficult for the body to break down the cell wall. An extract provides the contents of the cell after the cell wall has been broken. Greater adherence to Mediterranean diet associated with decreased cardiometabolic risk during pregnancy University of Granada, August 20, 2021 According to news reporting out of Granada, Spain,research stated, “Studies regarding dietary patterns and cardiometabolic risk markers during pregnancy are scarce. The aim of the present study was to analyse whether different degrees of adherence to the Mediterranean diet (MD) and the MD components were associated with cardiometabolic markers and a clustered cardiometabolic risk during pregnancy.” Our news journalists obtained a quote from the research from the University of Granada, “This study comprised 119 pregnant women from the GEStation and FITness (GESTAFIT) project. Dietary habits were assessed with a food frequency questionnaire at the 16th and 34th gestational weeks (g.w.). The Mediterranean Diet Score was employed to assess MD adherence. The following cardiometabolic markers were assessed: pre-pregnancy body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting glucose, triglycerides and high-density lipoprotein cholesterol (HDL-C). A greater MD adherence was associated with a better cardiometabolic status in cross-sectional (16th g.w. and 34th g.w.) and prospective analyses (MD adherence at the 16th g.w. and cardiometabolic markers at the 34th g.w.; SBP, DBP and HDL-C; all, p< 0.05). Participants with the highest MD adherence (Tertile 3) had a lower clustered cardiometabolic risk than those with the lowest MD adherence (Tertile 1) at the 16th and 34th g.w. (both, p< 0.05). A higher intake of fruits, vegetables and fish and a lower intake of refined cereals and red meat and subproducts were associated with a lower cardiometabolic risk during pregnancy (all, p< 0.05).” According to the news editors, the research concluded: “A higher MD adherence, a greater intake of fruits, vegetables and fish and a lower intake of refined cereals and red meat and subproducts showed a cardioprotective effect throughout gestation.” Unhealthy diet during pregnancy could be linked to ADHD King's College London and the University of Bristol , August 20, 2021 New research led by scientists from King's College London and the University of Bristol has found that a high-fat, high-sugar diet during pregnancy may be linked to symptoms of ADHD in children who show conduct problems early in life. Published in the Journal of Child Psychology and Psychiatry, this study is the first to indicate that epigenetic changes evident at birth may explain the link between unhealthy diet, conduct problems and ADHD. Early onset conduct problems (e.g. lying, fighting) and attention-deficit/hyperactivity disorder (ADHD) are the leading causes of child mental health referral in the UK. These two disorders tend to occur in tandem (more than 40 per cent of children with a diagnosis of conduct disorder also have a diagnosis of ADHD) and can also be traced back to very similar prenatal experiences such as maternal distress or poor nutrition. In this new study of participants from the Bristol-based ‘Children of the 90s' cohort, 83 children with early-onset conduct problems were compared with 81 children who had low levels of conduct problems. The researchers assessed how the mothers' nutrition affected epigenetic changes (or DNA methylation) of IGF2, a gene involved in fetal development and the brain development of areas implicated in ADHD – the cerebellum and hippocampus. Notably, DNA methylation of IGF2 had previously been found in children of mothers who were exposed to famine in the Netherlands during World War II. The researchers from King's and Bristol found that poor prenatal nutrition, comprising high fat and sugar diets of processed food and confectionary, was associated with higher IGF2 methylation in children with early onset conduct problems and those with low conduct problems. Higher IGF2 methylation was also associated with higher ADHD symptoms between the ages of 7 and 13, but only for children who showed an early onset of conduct problems. Dr Edward Barker from King's College London said: ‘Our finding that poor prenatal nutrition was associated with higher IGF2 methylation highlights the critical importance of a healthy diet during pregnancy. These results suggest that promoting a healthy prenatal diet may ultimately lower ADHD symptoms and conduct problems in children. This is encouraging given that nutritional and epigenetic risk factors can be altered.' Dr Barker added: ‘We now need to examine more specific types of nutrition. For example, the types of fats such as omega 3 fatty acids, from fish, walnuts and chicken are extremely important for neural development. ‘We already know that nutritional supplements for children can lead to lower ADHD and conduct problems, so it will be important for future research to examine the role of epigenetic changes in this process.' Green tea may help protect against sunburn Taiyo Kagaku Co (Japan), August 24, 2021 A systematic review and meta-analysis published in a recent issue of Molecules found an association between oral intake or topical application of green tea catechins and a reduction in ultraviolet (UV) radiation-induced sunburn, which is an inflammatory reaction of the skin to UV exposure, clinically known as erythema.* Catechins are a type of flavonoid that occur in plants such as Camellia sinensis (tea). Green tea catechins include (-)-epigallocatechin-3-gallate (EGCG), well known for its anti-cancer and health-promoting effects, (-)-epicatechin, and many other similar molecules. These compounds have been recognized as having anti-inflammatory, antioxidant and photo-protective properties. “To our knowledge, this is the first meta-analysis to assess the effectiveness of green tea catechins specifically on measures of ultraviolet radiation-induced erythema and related pro-inflammatory mediators,” authors Mahendra P. Kapoor and colleagues wrote. “Regular intake of as low as 540 mg of green tea catechins per day could be beneficial for the protection against ultraviolet radiation-induced erythema, wherein green tea catechin metabolites are bioavailable at the dermis and epidermis levels of the skin, and thus increase the minimal dose of radiation (MED) required to induce erythema.” Dr Kapoor added that the study “suggests that green tea catechins can strengthen the skin's tolerance to ultraviolet radiation-induced skin damage from radiation through the prevention of the ultraviolet radiation-induced perturbation of epidermal barrier functions.” Study details: 12 weeks of green tea intake yields benefits The meta-analysis included three randomized, double-blind, placebo-controlled trials and one non-double-blind, non-placebo-controlled study that examined potential protective effects of orally administered capsules containing green tea catechins against sunburn (clinically known as erythema) induced by solar-simulated UV radiation. Two additional studies that involved a single dose of topically administered catechins were separately analyzed. Pooled analysis of data from three studies that evaluated erythema in skin exposed to UV radiation before and after 12 or more weeks of green tea catechin intake revealed a favorable effect in association with catechin intake. Both low and high doses of the green tea capsules were effective at decreasing low-dose UV radiation-induced erythema. It was also noted that a significant favorable effect was seen in the one study which assessed UV radiation-induced erythema after green tea intake for only six weeks, but as none of the other studies assessed this shorter duration of intake, further analysis was not performed. When green tea catechins' effects compared to a placebo were analyzed, pooling the data of two placebo-controlled trials confirmed their effectiveness against low-intensity UV radiation-induced erythema. Pooling data from participants in the studies involving topical green tea catechins revealed significant benefit for green tea at higher UV radiation doses.
CoQ10 supplementation associated with improved trauma patient outcomes Urmia University of Medical Sciences (Iran) July 23 2021. Findings from a trial reported on July 12, 2021 in the Journal of Nutritional Science revealed benefits for hospitalized traumapatients who were given supplements that contained coenzyme Q10. The trial enrolled 40 men and women with traumatic injury and low plasma levels of CoQ10. Participants received a placebo or 400 milligrams CoQ10 daily for seven days. Blood samples collected at the beginning and end of the trial were analyzed for interleukin 6 (IL-6), which may be elevated during inflammation, and the oxidative stress markers malondialdehyde (MDA) and thiobarbituric acid reactive substances (TBARS). Body composition was also assessed at these time points, as well secondary outcomes that included Sequential Organ Failure Assessment (SOFA) and the Glasgow Coma Scale (GCS). While interleukin-6 levels at the beginning of the study were similar between the CoQ10 and placebo groups at an average of 175.05 pg/mL and 177.82 pg/mL, they were reduced by 76.99 pg/mL in the CoQ10 group and 17.35 pg/mL in the placebo group. MDA values averaged 232.37 picograms per milliliter (pg/mL) and 239.96 pg/mL and were lowered by 88.84 pg/ml among participants who received CoQ10 and by 26.23 pg/mL among those who received a placebo. In comparison with the placebo group, fat free mass, skeletal muscle mass and body cell mass increased among those who received CoQ10. GCS and SOFA scores, and duration of hospital stay, ICU stay and ventilator use also improved among treated patients. “To date, no randomized clinical trial study has been conducted to evaluate the effect of CoQ10 supplementation in traumatic mechanical ventilated patients and we hypothesized that CoQ10 administration in these patients could have beneficial effects on biochemical and clinical factors,” the authors wrote. “We have shown that CoQ10 could improve some of the clinical and anthropometric parameters in patients with a traumatic injury.” Nigella sativa (black seed) prevents covid-induced vascular damage, scientists conclude Oriental Institute of Science and Technology (India), July 27, 2021 New research published in the journal Vascular Pharmacology shows that Nigella sativa, also known as black seed or black cumin, binds to ACE2 in the lungs, effectively stopping the Wuhan coronavirus (Covid-19) from inducing inflammation and vascular damage. Researchers out of India investigated the effects of nigellidine, an indazole alkaloid of black seed, using molecular docking for binding to different angiotensin-binding proteins, as well as the Chinese Virus spike glycoprotein. They found that nigellidine “strongly binds” to the Chinese Virus spike protein at what is known as the hinge region or active site opening, which may in turn hamper its binding to the nCoV2-ACE2 surface. “Nigellidine effectively binds in the Angiotensin-II binding site / entry pocket,” the study explains. “Nigellidine showed strong binding to mono / multi-meric ACE1.” This process of ACE blocking could, the study goes on to suggest, restore angiotensin levels and restrict vasoturbulence in Chinese Virus patients, while the receptor blocking could help to stop resulting inflammation and vascular impairment. “Nigellidine may slow down the vaso-fluctuations due to Angiotensin deregulations in Covid patients,” the paper further explains. “Angiotensin II-ACE2 binding (ACE-value -294.81) is more favorable than nigellidine-ACE2. Conversely, nigellidine-ACE1 binding-energy / Ki is lower than nigellidine-ACE2 values indicating a balanced-state between constriction-dilatation.” Nigellidine also binds to the viral spike proteins, which when taken by Chinese Virus patients, and especially those who fall in the elderly category, could greatly reduce their risk of suffering complications or death. Nigellidine impairs SARS-CoV-2 infection, “cytokine storm” through numerous mechanisms In a related study that was published last year in the journal Europe PMC, researchers learned that nigellidine inhibits the Chinese Virus infection in several other ways. It was discovered early on in the “pandemic” that many of those who tested “positive” for the virus were suffering associated “cytokine storms,” in which their immune systems were over-responding and causing more damage, or even death. Nigellidine was then studied and discovered to possess certain properties that inhibit cytokine storms, as well as impede the SARS CoV-2 virus from causing infection. It is also hepato- and reno-protective, meaning it protects against liver damage. Beyond this, nigellidine was determined to possess unique immunomodulatory and anti-inflammatory characteristics, as well as antioxidant potential strong enough to inhibit important proteins associated with the Chinese Virus. In their quest to uncover possible “drug” candidates to protect patients against hyper-inflammation and other associated problems, the researchers learned that nigellidine – and more than likely other black seed constituents – helps tremendously with preventing negative side effects. Along with nigellicine, nigellidine is found in the seed coat of Nigella sativa. Both of these constituents in their sulfated forms are extremely bioavailable, and along with thymoquinone and dithymoquinone, two other black seed components, they show strong antioxidant, antibacterial, anti-hypertensive, anti-inflammatory and immunomodulatory effects. Black seed extracts have been shown in other experiments to decrease oxidative stress, effectively lowering the risk of inflammation-related diseases. We now know that this includes the Wuhan coronavirus (Covid-19). Black seed is also recognized as a metabolic protector, helping to improve lipid and blood sugar levels. “Most importantly, in SARS CoV-2 infection ACE-2 mediated impairment of aldosterone system may be repaired by,” the study further explains, providing relevant information to the current “pandemic.” “Vasorelaxant and anti-hypertensive function of [black seed] helps in the modulation of renin angiotensin system (RAS) or the diuretic activity, which is one of the major targets of COVID. It might have great protective role during post infective secondary disorder of the peripheral vasculature namely cardiac and renal systems. In most of the instances patients die due to this organ dysfunction/failure in COVID-19 infection.” By quelling inflammation, black seed could save lives from covid Laboratory studies have found that intake of Nigella sativa significantly improves the parameters for hyperglycemia and diabetes control, as well as glycated hemoglobin and insulin resistance. Based on this, experts believe that nigellidine specifically could play an important role in fighting the Chinese Virus by “docking” to the proteins and inflammatory molecules that can cause a cytokine storm – mainly TNF-? receptors such as TNFR1, TNFR2 and IL1R. “In the experimental rat model the source of this drug Nigella sativa; black cumin seed extracts were tested for its role on antioxidant, hepatic and renal status,” the paper states. “This work will help in the urgent therapeutic intervention against COVID-19 global pandemic.” “In the current study, we have decisively shown by molecular modeling that nigellidine can bind in the active sites of several important proteins of SARS CoV 2, several host receptors specific for SARS CoV-2 induced inflammatory markers IL1, IL6, TNF-?. Moreover, the extract from black cumin seed has been shown in experimental rat to be highly antioxidative, hepato- and reno-protective. Further studies are necessary to verify the potential effects of nigellidine in in vivo laboratory experimental animal model.” Vitamin D supplementation improves recovery time of children with pneumonia at pediatric hospital Cairo University (Egypt), July 20, 2021 According to news reporting originating from Cairo, Egypt, by NewsRx correspondents, research stated, “Despite the well-recognized effect of vitamin D in metabolism and homeostasis, there is now growing interest in its probable association with pneumonia. This study aims to supply vitamin D3 (Cholecalciferol) (100,000 IU) to pneumonic children to minimize the duration of illness and improve their outcome.” Our news editors obtained a quote from the research from Cairo University, “A double-blinded, randomized, placebo-controlled trial was conducted in a Pediatric Cairo University affiliated hospital. An intervention arm (93 children) and a control arm (98 children), who had pneumonia with an insufficient or deficient level of vitamin D and whose parental permission was obtained, were enrolled in the trial. All children were treated with antibiotics according to WHO guidelines. Children were given a single injection of 1 mL of 100,000 IU of vitamin D3 or placebo. Clinical data were recorded every eight hours for all children. Outcomes were assessed 7 days after vitamin D injection. The primary outcome variable was the change in serum level of 25(OH)D, while the secondary outcomes were the medical state of the assigned cases (improvement or death) and duration between enrollment and hospital discharge for improved cases. In the supplementation group, the percentage of patients who suffered either deficient (38.7%) or insufficient levels (61.3%) of 25 (OH)D at day one had significantly decreased in the seventh day to (11.8%) and (52.7%), respectively. Kaplan--Meier plots highlighted that the median time to recover of the placebo group was significantly longer than that of the supplementation group (Log Rank P value < .001). VDD was detected in pediatric critical care children.” According to the news editors, the research concluded: “In pneumonic children with high VDD, it is illustrated that Vitamin D supplementation is accompanied by lowered mortality risk and pSOFA scores, reduced time to recover, and improved PaO2/FiO(2).” Physical activity could combat fatigue, cognitive decline in cancer survivors University of Illinois, July 26, 2021 A new study indicates that cancer patients and survivors have a ready weapon against fatigue and "chemo brain": a brisk walk. Researchers at the University of Illinois, along with collaborators at Digital Artefacts in Iowa City, Iowa, and Northeastern University in Boston, looked at the association between physical activity, fatigue and performance on cognitive tasks in nearly 300 breast cancer survivors. "The data suggest that being more physically active could reduce two of the more commonly reported symptoms in breast cancer survivors: fatigue and cognitive impairment," said study leader Edward McAuley, a professor of kinesiology and community health at Illinois. "Most people think, 'If I exercise, I'll become tired.' In our study, exercise actually was associated with reduced fatigue, which in turn was associated with better cognitive function." Cognitive impairment, such as memory problems or shortened attention spans, is a common complaint among cancer patients and survivors, and is thought to be similar to decline due to aging. Past Illinois research has explored the effect of physical fitness on age-related cognitive decline, so the researchers wondered whether cancer survivors would respond similarly to exercise. "Other studies of cancer survivors have relied on small samples of cancer survivors, and used self-reporting measures of physical activity and cognitive function, which can be very biased," said postdoctoral researcher Diane Ehlers, the first author of the study, which is published in the journal Breast Cancer Research and Treatment. "What makes our study novel is that we had objective measures for both physical activity and cognitive performance, and a nationwide sample of breast cancer survivors." The researchers worked with Digital Artefacts -- developer of the commercial neuroscience app BrainBaseline - to create an iPad app tailored to this study. The app included questionnaires and activities designed to measure attention, memory and multitasking skills. The researchers also sent each participant an accelerometer to track daily physical activity. "We found that higher levels of daily moderate-to-vigorous physical activity were associated with better performance on the cognitive tasks measuring attention, memory and multitasking," Ehlers said. "What was notable was that physical activity's effect on cognitive performance was mediated by fatigue. This provides evidence that physical activity interventions targeting fatigue in cancer patients and survivors might provide promising models for improving cognitive function as well." Next, the researchers plan to conduct further studies to establish causation and further explore the pathways of how physical exercise improves cognitive performance. They are working with Digital Artefacts to conduct an iPhone-based study and focusing on diverse populations of breast cancer survivors. "The message for cancer patients and survivors is, get active!" Ehlers said. "Even if it's 10-minute bouts of brisk walking. It's not a magical cure-all, but we've seen many benefits of physical activity for cancer patients and survivors." Cannabidiol promotes oral ulcer healing by inactivating CMPK2-mediated NLRP3 inflammasome Sichuan University (China), July 26, 2021 Xingying Qi, West China Hospital of Stomatology, Sichuan University, Chengdu, China, presented the oral session "Cannabidiol Promotes Oral Ulcer Healing by Inactivating CMPK2-Mediated NLRP3 Inflammasome" at the virtual 99th General Session & Exhibition of the International Association for Dental Research (IADR), held in conjunction with the 50th Annual Meeting of the American Association for Dental Research (AADR) and the 45th Annual Meeting of the Canadian Association for Dental Research (CADR), on July 21-24, 2021. The oral ulcer is a common oral inflammatory lesion with severe pain but little effective treatment is currently available. Cannabidiol (CBD) is recently emerging as a therapeutic agent for inflammatory diseases. However, the underlying mechanisms are not fully elucidated. Qi and colleagues sought to investigate whether and how CBD could play a therapeutic role in the oral ulcer. Oral ulcer models were performed in the tongue of C57BL/6 mice by acid etching or mechanical trauma, followed by CBD local administration. Samples were harvested for macroscopic and histological evaluation. CBD oral spray on acid- or trauma-induced oral ulcers on mice tongues inhibited inflammation, relieved pain and accelerated lesions closure in a dose-dependent manner. The results show that CBD accelerates oral ulcer healing by inhibiting CMPK2-mediated NLRP3 inflammasome activation and pyroptosis, which is mediated mostly by PPARγ in nucleus and partially by CB1 in plasma membrane. This data may shed light on the development of new therapeutic strategies for oral ulcers. Algal solution: Could Spirulina modify the microbiome to protect against age-related damage? Louvain Drug Research Institute (Belgium), July 25 2021 Spirulina might help protect against age-related liver inflammation by modifying pathways in the microbiome, say researchers. Consumption of spirulina could help protect against hepatic inflammation in the elderly, according to the new animal research published in Nutrients. Belgian researchers carried out tests on mice, which suggest that the algae Spirulina has an impact on the gut microbiota, which in turn activates the immune system in the gut and improves inflammation in the liver that is associated with ageing. Led by senior author Professor Nathalie Delzenne from the Louvain Drug Research Institute in Belgium, the team said oral feeding of Spirulina was found to modulates several immunological functions involving, among others, the TLR4 pathway in old mice. “The fact that its oral consumption can influence both gut immunity and systemic sites, such as the liver, suggests that its immune action is not confined to the gut immune system,” wrote the team – who said the findings open the way to new therapeutic tools “in the management of immune alterations in aging, based on gut microbe-host interactions.” Furthermore, they suggested that improvement of the homeostasis in the gut ecosystem ‘could be essential' during the aging process, “and, in this perspective, dietary manipulation of the gut microbiota of the elderly with Spirulina, may represent a tool for preserving a healthy gastrointestinal microbial community in addition to its beneficial effects on immune function.” Study details Delzenne and colleagues noted that while the possible cardiovascular and immune support benefits of Spirulina have been fairly widely reported, the new study brings a fresh approach by testing whether the effects could be related to a modulation of gut micrbiota. In the trial, young mice aged three months were fed a standard diet, while older mice aged 24 months were fed a standard diet either with or without 5% Spirulina for six weeks. Upton supplementation with Spirulina, the team reported several changes to gut microbiota composition, including an increase in Roseburia and Lactobacillus populations. “Interestingly, parameters related to the innate immunity are upregulated in the small intestine of Spirulina-treated mice,” said the team. “Furthermore, the supplementation with Spirulina reduces several hepatic inflammatory and oxidative stress markers that are upregulated in old mice versus young mice.” Expression of several genetic and biochemical markers of inflammation and immunity were altered by supplementation with Spirulina, said the team. In particular, the transcription factor Foxp3 – involved in the differentiation of T cells into regulatory T cells (Tregs) – and MCP1 were increased due to Spirulina supplementation in old mice. Old mice that consumed Spirulina also showed activation of several immune parameters including Foxp3 in the ileum – suggesting an improvement of the gut immune function upon Spirulina treatment in this segment, said the Belgian researchers. Furthermore, Spirulina supplementation upregulated both TLR2 and TLR4 expression in the ileum of aged mice. “In accordance with these results, a solution of Spirulina (5%) exhibited a TLR4 agonist activity similar to the one reached in old-SP mice, suggesting a direct effect of the Spirulina, itself, on the TLR4 pathway,” they added. Microbiome mechanisms While the positive effect of Spirulina on the microbiome and liver inflammation is clear, the team noted that the mechanism by which the algae could change the composition of the intestinal microbiota remains unanswered. One possible mechanism could be the presence of antimicrobial substances produced by Spirulina, they said. “On the other hand, antimicrobial peptides (AMPs) could be mediators of the nutritional modulation of the gut microbiota.” “In the present study, RegIIIγ and Pla2g2 were increased by the supplementation with Spirulina, suggesting that the host contributes to the reduction and modification of the microbial community by modulating the production of specific AMPs,” they added.
Stichwort Drehbuch - Der Podcast vom Verband Deutscher Drehbuchautoren (VDD)
Vor zwei Jahren schien die ARD in ihren Leitlinien für den Umgang mit Autoren auf die Forderungen von Kontrakt'18 und dem VDD einzugehen. Doch beide haben den Eindruck, dass die wolkigen Erklärungen in der Praxis kaum positive Wirkungen gezeigt haben. In einem gemeinsam unterzeichneten Brief an die bisherige Degeto-Chefin und neue ARD-Programmdirektorin Christine Strobl verlangt man jetzt klar festgelegte Änderungen im Umgang miteinander. Ansonsten würde das öffentliche Fernsehen den Anschluss an die international gewachsenen Erzählstandards vollends verlieren.
In deze aflevering van de podcast bespreekt Bastiaan Toorenent de teloorgang van de PTT, TPG, TNT en uiteindelijk PostNL. De Liberalen van de VDD en D66 beloofde met de privatisering, doorvoering van marktwerking en invoering van de participatie samenleving, dat services zouden verbeteren en de prijzen lager zouden worden. Vijfentwintig jaar nadat Kabinet Paars 1 ooit begonnen is aan deze liberale gedachten kunnen we constateren dat de service alleen maar is verslechterd en de prijzen enorm zijn gestegen, zegt Bastiaan. Het winst moeten maken op iets wat eigenlijk een overheidsdienst zou moeten zijn blijkt uit alle voorbeelden onmogelijk. Daarom is met name het huidige te laat bezorgen en kwijtraken van examens door PostNL het ultieme bewijs dat Liberalisme niet werkt! --- Send in a voice message: https://anchor.fm/bastiaan-toorenent1/message
Zusätzlich zum Interview mit dem Berufsverband der Diätassistent*innen (VDD) erfahrt ihr heute: Welche Verbände sind interessant für DAs? Du bekommst eine Übersicht! Was bieten die Verbände? Warum solltest du in einem Verband sein? Du bist dir unschlüssig? Inspiration inklusive! Wir berichten dir wieso, weshalb, warum wir uns für einen Verband entschieden haben!
Der VDD (Verband der Diätassistenten – Deutscher Bundesverband e.V.) ist der einzige Berufsverband nur für Diätassistent*innen in Deutschland. Und DAs gehören zu DAs, ist doch klar! Oder? Aber was kann der VDD eigentlich? Was tut er für die Berufsgruppe? Was hat der Verband bisher erreicht und wo will er hin? Was bietet er uns jungen Berufseinsteiger*innen? Und was bietet mir der VDD persönlich? Warum sollte ich in einen Berufsverband eintreten und Mitgliedbeiträge zahlen? Anfangs ist wohl das VDD-Zertifikat eine Motivation. Allerdings bietet der VDD einiges mehr! Kennst du das? - Du bist dir unsicher, ob der Arbeitsvertrag sauber ist? Der VDD bietet auch rechtliche Unterstützung - Du stehst vor einem diätetischen Problem? Finde die passenden Ansprechpartner*innen - Tarifverhandlung? Kein Plan? Der VDD liefert dir Textbausteine - Ihr habt eine Umfrage erstellt und hofft auf hohe Beteiligung? Der VDD kann sie über ihren Verteiler laufen lassen Aber warum ist berufspolitisch bei DAs immer noch so viel in Schieflage? Wir haben schließlich immer noch ein Problem mit unserer Anerkennung und unserem Namen… Wir haben mit VDD-Präsidentin Uta Köpcke und Vize-Präsident Matthias Zöpke gesprochen. Sie erklären uns berufspolitische Zusammenhänge, Abläufe und Problematiken. Wir beginnen zu verstehen und möchten noch mehr wissen! Wie siehts bei euch aus?
Host Kevin Patton outlines several new discoveries, including the function of background noise in the brain, how exercise triggers immunity, a possible blood marker for longevity, and how mitochondria are organized during cell division. And he discusses how easy animation effects can help students focus on important elements of the story of anatomy and physiology. 00:00 | Quotation & Intro 00:47 | Brain's Background Noise 08:06 | Sponsored by AAA 09:12 | How Exercise Triggers Immunity 13:30 | Sponsored by HAPI 14:41 | Mitochondria During Cell Division 22:10 | Sponsored by HAPS 23:03 | How Old Will We Get 26:22 | Focus Our Story on Slides 35:22 | The Scoop About Segments 36:33 | Smooth Slides for a Smooth Story 43:56 | Staying Connected If you cannot see or activate the audio player click here. Apply for your credential (badge/certificate) for listening to this episode. Please take the anonymous survey: theAPprofessor.org/survey Questions & Feedback: 1-833-LION-DEN (1-833-546-6336) Follow The A&P Professor on Twitter, Facebook, Blogger, Nuzzel, Tumblr, or Instagram! We deal with our mind from morning till evening, and it can be our best friend or our worst enemy. (Mathieu Ricard) Brain's Background Noise 7 minutes The so-called "background noise" in an electroencephalogram (EEG)—that aperiodic data that contrasts with the periodic waves we usually look for—may be a measure of consciousness. Brain's ‘Background Noise' May Hold Clues to Persistent Mysteries (Quanta magazine article) my-ap.us/3lisLqW Most brain activity is "background noise" — and that's upending our understanding of consciousness (Salon magazine article) my-ap.us/30KWq2q Sponsored by AAA 1 minute A searchable transcript for this episode, as well as the captioned audiogram of this episode, are sponsored by the American Association for Anatomy (AAA) at anatomy.org. Searchable transcript Captioned audiogram Don't forget—HAPS members get a deep discount on AAA membership! Sign up for the new VDD or Virtual Dissection Database. You can access it at www.virtualdissectiondatabase.com How Exercise Triggers Immunity 4 minutes We know that exercise has many beneficial effects in the body, including stimulation of the immune system. A new discovery in mice suggests that the same pressure that triggers bone growth with exercise also triggers the precursors to lymphocytes in bone marrow. Exercise generates immune cells in bone (article in Nature) my-ap.us/30JA4i5 Sponsored by HAPI Online Graduate Program 1 minute The Master of Science in Human Anatomy & Physiology Instruction—the MS-HAPI—is a graduate program for A&P teachers, especially for those who already have a graduate/professional degree. A combination of science courses (enough to qualify you to teach at the college level) and courses in contemporary instructional practice, this program helps you be your best in both on-campus and remote teaching. Kevin Patton is a faculty member in this program. Check it out! nycc.edu/hapi Mitochondria During Cell Division 7.5 minutes We know how the nuclear genome is organized into two equivalent groups during cell division—at least the broad strokes. A new discovery sheds light on complex mechanisms that distribute the mitochondrial genome. Actin cables and comet tails organize mitochondrial networks in mitosis (article in Nature) my-ap.us/30J7cX4 Sponsored by HAPS 1 minute The Human Anatomy & Physiology Society (HAPS) is a sponsor of this podcast. You can help appreciate their support by clicking the link below and checking out the many resources and benefits found there. Watch for virtual town hall meetings and upcoming regional meetings! Anatomy & Physiology Society theAPprofessor.org/haps How Old Will We Get? 3 minutes A study of 90- to 100-year-olds suggests that there's a blood marker that might give clues to our longevity. More than 100 centenarians help to reveal a biomarker for long life (news item in Nature) my-ap.us/2NlN8a9 A neuronal blood marker is associated with mortality in old age (article in Nature Aging) my-ap.us/30Kxngf Focus our Story on Slides 9 minutes It's best to have few, if any, phrases of text on our teaching slides—so that students will focus on our orally presented story of anatomy and physiology. But when we do need more than a phrase or two—a term or two—then using simple animations to bring them in one at a time works well. Slides Serve the Story of Anatomy & Physiology | Episode 66 PowerPoint: Animating Text and Objects (video) my-ap.us/30NBeZW The Scoop About Segments 1 minute Chunking. I use segments to divide the episode partly to give room for sponsor messages (thank you, sponsors!), but also to chunk the content so that it doesn't feel like you are drinking from a fire house. You know?... a bit of a cognitive "breather" before moving on to the next thing. How to use chapter markers in Apple's Podcasts app (a how-to for flipping from segment to segment; also works similarly in other podcast platforms) my-ap.us/3bVFoVZ Smooth Slides for a Smooth Story 7.5 minutes Smooth and subtle animations for bringing in new slide elements work better that jarring "appear" animations or wildly sliding or jumping or scrolling animations. This is especially important when considering accessibility for those with motion-sensitive conditions. Smooth... that should be our mantra! The Golden Voice Behind All Those Ken Burns Documentaries (about Peter Coyote, mentioned in this episode) https://my-ap.us/3tranz1 If the hyperlinks here are not active, go to TAPPradio.org to find the episode page. More details at the episode page. Transcript available in the transcript box. Listen to any episode on your Alexa device. Need help accessing resources locked behind a paywall? Check out this advice from Episode 32 to get what you need! https://youtu.be/JU_l76JGwVw?t=440 Take The A&P Professor experience to the next level! The A&P Professor community Earn cash by referring other A&P faculty to this podcast: theAPprofessor.org/refer Tools & Resources Amazon Text Expander Rev.com Snagit & Camtasia Krisp Free Noise-Cancelling App The A&P Professor Logo Items Sponsors Transcript and captions for this episode are supported by the American Association for Anatomy | anatomy.org The Human Anatomy & Physiology Society provides marketing support for this podcast | theAPprofessor.org/haps Distribution of this episode is supported by NYCC's online graduate program in Human Anatomy & Physiology Instruction (HAPI) | nycc.edu/hapi Clicking on sponsor links helps let them know you appreciate their support of this podcast! Follow The A&P Professor on Twitter, Facebook, Blogger, Nuzzel, Tumblr, or Instagram! The A&P Professor® and Lion Den® are registered trademarks of Lion Den Inc. (Kevin Patton) As an Amazon Associate I earn from qualifying purchases. I may be compensated for links to sponsors and certain other links.
Blueberries protect against inflammation Texas Women's University, March 14, 2021 In a recent study, researchers at Texas Woman’s University investigated the usefulness of polyphenols present in blueberries in controlling or reducing inflammation. Induced by oxidative stress, inflammation — especially if it becomes persistent — is closely linked to the development of many chronic diseases, such as diabetes, metabolic syndrome, inflammatory bowel disease and rheumatoid arthritis (RA). The researchers discussed the anti-inflammatory activities of BBPs in an article published in the Journal of Medicinal Food. Blueberry polyphenols can be used for the treatment of rheumatoid arthritis RA is an autoimmune and chronic inflammatory disease that destroys joints and causes disability in older adults. The etiology of RA is poorly understood and there is no mainstream cure for this disease. According to research, the accumulation and proliferation of fibroblast-like synoviocytes — non-immune cells that make up the membranous tissue that lines joint cavities — may be involved in the destruction of cartilage commonly observed in RA. On the other hand, in vivo and in vitro studies suggest that the anti-inflammatory properties of dietary polyphenols derived from fruits and vegetables could help prevent this destruction. To examine the anti-inflammatory activities of blueberry polyphenols against RA, the researchers first stimulated rabbit synoviocytes with tumor necrosis factor alpha (TNF-a), a cell signaling protein (cytokine) released by immune cells that plays a huge role in systemic inflammation. They then treated the synoviocytes with different doses of blueberry polyphenols. The researchers found that the pro-inflammatory cytokine, TNF-a, increased synoviocyte proliferation by around 19 percent, but treatment with blueberry polyphenols significantly decreased proliferation in a dose-dependent manner. The polyphenol-treated synoviocytes also showed decreased levels of interleukin (IL)-1B and nuclear factor-kappa B (NF-kB). IL-1B is a cytokine required for activating the innate immune response. Its role is to mediate the release of other pro-inflammatory cytokines, especially in the presence of an infection. NF-kB, on the other hand, is a transcription factor that regulates the expression of genes involved in inflammation. The researchers also reported that that the expression of matrix metalloproteinase 3, a key enzyme involved in the pathogenesis of RA, increased fivefold in the control TNF-a-stimulated group but decreased by threefold in the blueberry polyphenol-treated group, clearly showing the anti-RA activities of blueberry’s active components. Based on these findings, the researchers concluded that blueberry polyphenols can reduce inflammation associated with RA by downregulating the expression of pro-inflammatory cytokines and the transcription factor, NF-kB. Relationship between vitamin D deficiency and gestational and postpartum depression Federal University of Rio de Janeiro (Brazil), March 16, 2021 According to news originating from Rio de Janeiro, Brazil, research stated, “Vitamin D deficiency (VDD) has been associated with depressive symptoms in pregnancy and postpartum, which can result in increased adverse outcomes in the maternal-infant segment. A possible explanation in the literature is VDD relationship with genetic and neurological mechanisms.” Our news journalists obtained a quote from the research from Federal University Rio de Janeiro, “to evaluate VDD relationship with gestational and postpartum depression. this review followed the recommendations proposed by the Preferred Reporting Items for Systematic Reviews and Meta-Analysis. Research was conducted in electronic databases, PubMed and LILACS, including studies of the analytical type (cross-sectional and longitudinal), systematic reviews, meta-analyses, and controlled clinical trials carried out in humans; inclusion and exclusion criteria were applied. in this systematic review, eight articles were analyzed comprising 8,583 women from seven different countries. Among the selected articles, six found an association between VDD and gestational and postpartum depression. Considering the data collection, it was possible to conclude that there is a probable relationship between VDD and a higher predisposition to gestational and postpartum depression.” According to the news editors, the research concluded: “Also, we concluded that vitamin D supplementation has proven to be a promising strategy for reducing the risk of depressive symptoms.” Lifestyle intervention is beneficial for most people with type 2 diabetes, but not all Wake Forest Medical Center, March 11, 2021 For people who are overweight or obese and have type 2 diabetes, the first line of treatment is usually lifestyle intervention, including weight loss and increased physical activity. While this approach has cardiovascular benefit for many, it can be detrimental for people who have poor blood sugar control, according to a study conducted by researchers at Wake Forest School of Medicine. In the study, published in the current issue of the journal Diabetes Care, the researchers re-evaluated the National Institutes of Health Action for Health in Diabetes (Look AHEAD) study that found intensive lifestyle intervention (ILI) neither helped nor hurt people with diabetes. "Contrary to the initial findings of Look AHEAD, our work found that lifestyle interventions reduced potential cardiovascular harm and optimized benefits for 85% of those in the trial," said the study's lead investigator, Michael P. Bancks, Ph.D., assistant professor of public health sciences at Wake Forest School of Medicine, part of Wake Forest Baptist Health. "However, for those who had poor blood sugar control, lifestyle intervention increased the risk of major cardiovascular events. Based on our findings, doctors may want to consider alternative options, such as glucose-lowering drugs, before trying lifestyle modification for those people." Look AHEAD randomized 5145 participants with type 2 diabetes (T2D) who were overweight or obese to 10 years of ILI or a control group that received diabetes support and education. ILI focused on weight loss through decreased caloric intake and increased physical activity. In the Wake Forest School of Medicine study, the researchers divided the study participants into four subgroups: diabetes onset at older age, poor glycemic control, severe obesity and younger age at onset. These subgroups were determined based on diabetes diagnosis, body mass index, waist circumference, measure of blood sugar value (glycemic control) and the age of diabetes onset. Bancks and his team examined each group's response to the intensive lifestyle intervention and its association with major cardiovascular events. In the subgroup with poor glycemic control, the intervention was associated with 85% higher risk of having a cardiovascular event as compared to the control group. Among the three other diabetes subgroups analyzed, ILI was not associated with an increased risk of fatal and non-fatal cardiovascular events. "Although the interest in diabetes subgroups is growing, our study is one of the first to apply it to lifestyle intervention," Bancks said. "So for clinicians, determining which subgroup their patient most closely resembles should help them determine the best treatment option and reduce any potential harm for that individual." These results provide support for further investigation into whether these findings apply to other diabetes complications, including cognitive issues, and to assess what interventions would be beneficial for those individuals, Bancks said. Depression doubles risk of death after heart attack, angina Intermountain Medical Center Heart Institute, March 8, 2021 Depression is the strongest predictor of death in the first decade following a diagnosis of coronary heart disease, according to a study scheduled for presentation at the American College of Cardiology's 66th Annual Scientific Session. The study found people with coronary heart disease who are diagnosed with depression are about twice as likely to die compared with those who are not diagnosed with depression. "This study shows that it doesn't matter if depression emerges in the short term or a few years down the road—it's a risk factor that continually needs to be assessed," said Heidi May, PhD, a cardiovascular epidemiologist at the Intermountain Medical Center Heart Institute in Salt Lake City and the study's lead author. "I think the take-home message is that patients with coronary disease need to be continuously screened for depression, and if found to be depressed, they need to receive adequate treatment and continued follow-up." The study focused on patients diagnosed with a heart attack, stable angina or unstable angina, all of which are caused by a reduced flow of oxygen-rich blood to the heart, typically as a result of plaque buildup in the heart's arteries. These conditions fall under the umbrella term coronary heart disease, which is the most common form of heart disease in the United States . Researchers have long understood heart disease and depression to have a two-way relationship, with depression increasing the likelihood of heart disease and vice versa. Whereas previous studies have investigated depression occurring within a few months of a coronary heart disease diagnosis, the new study is the first to shed light on the effects of depression over the long term. The researchers analyzed health records from almost 25,000 Intermountain Health System patients tracked for an average of nearly 10 years following a diagnosis of coronary heart disease. About 15 percent of patients received a follow-up diagnosis of depression, a substantially larger proportion than the estimated rate of 7.5 to 10 percent in the general population. Out of 3,646 people with a follow-up diagnosis of depression, half died during the study period, compared to 38 percent of the 20,491 people who did not have a depression diagnosis. This means people with depression were twice as likely to die compared to those without depression. After adjusting for age, gender, risk factors, other diseases, heart attack or chest pain, medications and follow-up complications, the results showed depression was the strongest predictor of death in this patient group. These results were consistent regardless of age, gender, the timing of depression onset, past history of depression or whether or not the patient had a heart attack. Given the significant impact of depression on long-term survival, the researchers said clinicians should seek ways to better identify depression in patients with coronary heart disease, either by using patient questionnaires designed to screen for depression or by actively watching for signs of depression during follow-up examinations. "It can be devastating to be diagnosed with coronary artery disease," May said. "Clinicians need to pay attention to the things their patients are expressing, in terms of both physical symptoms as well as emotional and nonverbal factors." Signs of depression include persistent feelings of sadness, hopelessness or worthlessness; anxiety, irritability or restlessness; losing interest in hobbies and activities; fatigue or moving slowly; difficulty sleeping or concentrating; aches or pains without a clear physical cause; changes in appetite or weight; and thoughts of death or suicide. Depression is linked with behaviors that can be detrimental to cardiovascular health, such as reduced physical activity, poor diet, increased smoking or alcohol use and reduced compliance with medical treatment. The study did not evaluate the impact of depression treatment on the risk of death. Wild mint can prevent blood sugar spikes after meals, reports study National Chemical Laboratory (India), March 12, 2021 Mentha arvensis, commonly known as wild mint, is a perennial flowering plant. Wild mint leaves and essential oil are also traditionally used as natural medicines. The former is said to be a great remedy for liver inflammation, peptic ulcer, diarrhea, bronchitis, jaundice and skin diseases, while the latter is often used as an antiseptic. Because of the reported antioxidant activity of wild mint, Indian researchers decided to investigate if it also has antidiabetic properties. In a recent study, which appeared in the Journal of Ayurveda and Integrative Medicine, the researchers looked at the potential of wild mint leaf extract to stop glycation. Glycation refers to the chemical reaction by which a sugar molecule attaches to a protein or lipid. This event is a consequence of hyperglycemia and is associated with the tissue damage often seen in diabetes. The researchers also explored the effect of wild mint extracts on the activity of two carbohydrate-digesting enzymes, as well as their influence on postprandial hyperglycemia. Wild mint extract can prevent blood sugar spikes after meals According to the researchers, interest in the use of alternative medicines to control diabetes, oxidative stress and related disorders has increased in recent years. This is due to the continuous rise in the number of people who develop diabetes around the world. In 2018, this number was estimated to be around 340 million, 70 million of which were from India. Postprandial hyperglycemia, or the increase in blood glucose after eating, is strongly implicated in the development of Type 2 diabetes and diabetic complications. Researchers believe that reducing the postprandial release of glucose in the blood is a promising therapeutic approach to treat or prevent diabetes. To achieve this, two enzymes involved in the breakdown of carbohydrates into sugar are considered as good antidiabetic targets. a-Amylase is a digestive enzyme that converts complex carbs like starch to simple sugars. Similarly, a-glucosidase hastens the digestion of oligosaccharides — three to 10 simple sugars linked together — and disaccharides (e.g., sucrose, maltose, lactose) into glucose molecules. Because of their functions, compounds that can inhibit a-amylase and a-glucosidase activity are used to reduce blood sugar levels in diabetics. Wild mint is a medicinal herb with a long history of use in traditional medicine. Ancient healers considered it a promising natural remedy for diabetes. To investigate its ability to inhibit postprandial hyperglycemia, the researchers first derived wild mint extract from its leaves using methanol as solvent. They then tested the extract on male rats and performed various in vitro experiments to evaluate the extract’s antidiabetic activity. The researchers reported that the wild mint extract showed a remarkable ability to scavenge free radicals, as well as great potential to inhibit glycation. They noted that it successfully inhibited more than 90 percent of advanced glycation end product (AGE) formation. The wild mint extract also showed high inhibitory activity against a-amylase and ?-glucosidase and significantly inhibited postprandial hyperglycemia in rats with starch-induced diabetes. Based on these findings, the researchers concluded that wild mint has noninsulin-dependent antidiabetic activity and can be used to treat or prevent postprandial hyperglycemia. Exercise during pregnancy may save kids from health problems as adults University of Virginia, March 15, 2021 Exercise during pregnancy may let mothers significantly reduce their children's chances of developing diabetes and other metabolic diseases later in life, new research suggests. A study in lab mice has found that maternal exercise during pregnancy prevented the transmission of metabolic diseases from an obese parent - either mother or father - to child. If the finding holds true in humans, it will have "huge implications" for helping pregnant women ensure their children live the healthiest lives possible, the researchers report in a new scientific paper. This means that one day soon, a woman's first trip to the doctor after conceiving might include a prescription for an exercise program. "Most of the chronic diseases that we talk about today are known to have a fetal origin. This is to say that the parents' poor health conditions prior to and during pregnancy have negative consequences to the child, potentially through chemical modification of the genes," said researcher Zhen Yan, PhD, a top exercise expert at the University of Virginia School of Medicine. "We were inspired by our previous mouse research implicating that regular aerobic exercise for an obese mother before and during pregnancy can protect the child from early onset of diabetes. In this study, we asked the questions, what if an obese mother exercises only during pregnancy, and what if the father is obese?" Exercise and Pregnancy Scientists have known that exercise during pregnancy helps lead to healthy babies, reducing the risk of pregnancy complications and premature delivery. But Yan, the director of the Center for Skeletal Muscle Research at UVA's Robert M. Berne Cardiovascular Research Center, wanted to see if the benefits continued throughout the children's lives. And his work, both previous and new, suggests it does. To determine that, Yan and his collaborators studied lab mice and their offspring. Some of the adult mice were fed typical mouse chow before and during pregnancy, while other were fed a high-fat, high-calorie diet to simulate obesity. Some receiving the high-fat diet before mating had access to a voluntary running wheel only during pregnancy, where they could run all they liked, while others did not, meaning they remained sedentary. The results were striking: Both mothers and fathers in the high-fat group could predispose their offspring to metabolic disorders. In particular, male offspring of the sedentary mothers on high-fat diets were much more likely to develop high blood sugar and other metabolic problems in adulthood. To better understand what was happening, the researchers looked at the adult offspring's metabolism and chemical (epigenetic) modification of DNA. They found there were significant differences in metabolic health and how active certain genes were among the different groups of offspring, suggesting that the negative effects of parental obesity, although different between the father and the mother, last throughout the life of the offspring. The good news is that maternal exercise only during pregnancy prevented a host of "epigenetic" changes that affect the workings of the offspring's genes, the researchers found. Maternal exercise, they determined, completely blocked the negative effects of either mother's or father's obesity on the offspring. The results, they say, provide the first evidence that maternal exercise only during pregnancy can prevent the transmission of metabolic diseases from parent to child. "The take-home message is that it is not too late to start to exercise if a mother finds herself pregnant. Regular exercise will not only benefit the pregnancy and labor but also the health of the baby for the long run," Yan said. "This is more exciting evidence that regular exercise is probably the most promising intervention that will help us deter the pandemic of chronic diseases in the aging world, as it can disrupt the vicious cycle of parents-to-child transmission of diseases." Some veggies each day keeps the stress blues away University of Sydney, March 15, 2021 Published in the British Medical Journal Open, the longitudinal study of more than 60,000 Australians aged 45 years and above measured participants fruit and vegetable consumption, lifestyle factors and psychological distress at two time points . Psychological distress was measured using the Kessler Psychological Distress Scale, a 10-item questionnaire measuring general anxiety and depression. Usual fruit and vegetable consumption was assessed using short validated questions. Key findings People who ate 3-4 daily serves of vegetables had a 12 per cent lower risk of stress than those who ate 0-1 serves daily. People who ate 5-7 daily serves of fruit and vegetables had a 14 per cent lower risk of stress than those who ate 0-4 serves daily. Women who ate 3-4 daily serves of vegetables had an 18 per cent lower risk of stress than women who ate 0-1 serves daily. Women who ate 2 daily serves of fruit had a 16 per cent lower risk of stress than women who ate 0-1 serves daily. Women who ate 5-7 daily serves of fruit and vegetables had a 23 per cent lower risk of stress than women who ate 0-1 serves daily. At the start of the study, characteristics associated with higher stress included: being female, younger, having lower education and income, being overweight/obese, a current smoker and being physically inactive. Fruit consumption alone had no significant association with a lower incidence of stress. There was no significant association between higher levels of fruit and vegetable intake (greater than 7 daily serves) and a lower incidence of stress. "This study shows that moderate daily fruit and vegetable consumption is associated with lower rates of psychological stress," said Dr Melody Ding of the University of Sydney's School of Public Health. "It also reveals that moderate daily vegetable intake alone is linked to a lower incidence of psychological stress. Moderate fruit intake alone appears to confer no significant benefit on people's psychological stress." These new findings are consistent with numerous cross sectional and longitudinal studies showing that fruit and vegetables, together and separately, are linked with a lower risk of depression and higher levels of well-being assessed by several measures of mental health. "We found that fruit and vegetables were more protective for women than men, suggesting that women may benefit more from fruit and vegetables," said first author and University of Sydney PhD student, Binh Nguyen. The investigators say further studies should investigate the possibility of a 'threshold' between medium and higher levels of fruit and vegetable intake and psychological stress.
Ever wonder why topics in A&P seem to have a uniform order of topics in all the courses & textbooks? Host Kevin Patton discusses the proper order of those concepts. We continue the discussion of gamification, including a focus on leaderboards. And we tackle why pandemic learning causes students to lament that they have to teach themselves. 00:00 | Quotation & Intro 00:44 | More on Gamification 06:20 | Sponsored by AAA 07:38 | Leaderboard Competition 16:02 | Sponsored by HAPI 17:16 | Pandemic Feelings of Learning 25:12 | Sponsored by HAPS 26:16 | Order of A&P Topics 35:27 | TAPP Community 36:03 | The Proper Order? 41:18 | Staying Connected If you cannot see or activate the audio player click here. Apply for your credential (badge/certificate) for listening to this episode. Please take the anonymous survey: theAPprofessor.org/survey Questions & Feedback: 1-833-LION-DEN (1-833-546-6336) Follow The A&P Professor on Twitter, Facebook, Blogger, Nuzzel, Tumblr, or Instagram! I never teach my pupils, I only attempt to provide the conditions in which they can learn. (Albert Einstein) More on Gamification 5.5 minutes We revisit how Kevin uses Badgr badges in his course and in the TAPP-ed program—including the main steps for setting up either badges internal to the learning management system (LMS) or external to the LMS. Listening to the previous episode is a good idea! Micro-Credentials & Gamification in the A&P Course | Brown & Black Skin | Refresher Tests | TAPP 87 Gamifying Education: Motivation and the Implementation of Digital Badges for Use in Higher Education (journal article) my-ap.us/3rxneig The Usefulness of Digital Badges in Higher Education - Exploring the Student Perspectives (journal article) my-ap.us/2MLz4GL The Elements of Gamification Learning in Higher Education: A Systematic Literature Review my-ap.us/36SntfJ Sample form platforms Google Forms my-ap.us/2AfzbQU JotForm jotform.com (Kevin's favorite) Sample automation services Zapier zapier.com IFTTT ifttt.com Integromat www.integromat.com/en Badgr.com Sponsored by AAA 1.5 minutes A searchable transcript for this episode, as well as the captioned audiogram of this episode, are sponsored by the American Association for Anatomy (AAA) at anatomy.org. Searchable transcript Captioned audiogram Don't forget—HAPS members get a deep discount on AAA membership! Sign up for the new VDD or Virtual Dissection Database. You can access it at www.virtualdissectiondatabase.com Leaderboard Competition 8.5 minutes Competition can be a potent part of the gamification strategy in education. This competition can motivate students to keep going and keep succeeding. One way to to support this kind of competition and collaboration is to use a leaderboard. Leaderboards are built into the Badgr microcredential system— as well as other microcredential systems. The effect of challenge-based gamification on learning: An experiment in the context of statistics education (recent research study on using leaderboards in higher ed) my-ap.us/3sg4Drg Kevin's badge page for his Pre-A&P students lionden.com/fis-badges.htm Duolingo (free app for learning a new language, where Kevin is currently experiencing the advantages of gamification as he learns the Esperanto lingvo, er, language) www.duolingo.com/info Using Badgr's Course Leaderboard my-ap.us/3aLovfP Gamification in Science Education. A Systematic Review of the Literature. (review article from the journal Education Sciences)my-ap.us/3khSy2b The Gamification of Learning: a Meta-analysis (journal article from Educational Psychology Review) my-ap.us/2NPf0U2 Sponsored by HAPI Online Graduate Program 1 minute The Master of Science in Human Anatomy & Physiology Instruction—the MS-HAPI—is a graduate program for A&P teachers, especially for those who already have a graduate/professional degree. A combination of science courses (enough to qualify you to teach at the college level) and courses in contemporary instructional practice, this program helps you be your best in both on-campus and remote teaching. Kevin Patton is a faculty member in this program. Check it out! nycc.edu/hapi Pandemic Feelings of Learning 8 minutes Applying what we learned from The A&P Professor Journal Club in Episode 83, we examine that common student lament heard while pandemic teaching: I feel like I have to teach myself! Just one element of the pandemic teaching & learning experience, maybe this one is partly explained by the natural gap between "feelings of learning" and "actual learning" experience when moving from passive to active learning strategies. Maybe. Actual Learning vs. Feeling of Learning | Journal Club Episode | TAPP 83 86 | What a Year! | Pandemic Teaching & More | A Reflection (features Kevin's psychic predictions) Desirable Difficulty | More Web Meeting Skills | TAPP 78 Sponsored by HAPS 1 minute The Human Anatomy & Physiology Society (HAPS) is a sponsor of this podcast. You can help appreciate their support by clicking the link below and checking out the many resources and benefits found there. Watch for virtual town hall meetings and upcoming regional meetings! Anatomy & Physiology Society theAPprofessor.org/haps Order of A&P Topics 9 minutes Ever wonder how the nearly universal order or sequence of A&P topics got settled? The mystery is revealed in this segment! ❤️ Discount subscription to The A&P Professor Community → theAPprofessor.org/Insider21 (good through Feb 2021) The Proper Order? 5 minutes Another mystery revealed: the proper order of topics in the A&P course. Really. The definitive answer! If the hyperlinks here are not active, go to TAPPradio.org to find the episode page. More details at the episode page. Transcript available in the transcript box. Listen to any episode on your Alexa device. Need help accessing resources locked behind a paywall? Check out this advice from Episode 32 to get what you need! https://youtu.be/JU_l76JGwVw?t=440 Take The A&P Professor experience to the next level! The A&P Professor community Earn cash by referring other A&P faculty to this podcast: theAPprofessor.org/refer Tools & Resources Amazon Text Expander Rev.com Snagit & Camtasia Krisp Free Noise-Cancelling App The A&P Professor Logo Items Sponsors Transcript and captions for this episode are supported by the American Association for Anatomy | anatomy.org The Human Anatomy & Physiology Society provides marketing support for this podcast | theAPprofessor.org/haps Distribution of this episode is supported by NYCC's online graduate program in Human Anatomy & Physiology Instruction (HAPI) | nycc.edu/hapi Clicking on sponsor links helps let them know you appreciate their support of this podcast! Follow The A&P Professor on Twitter, Facebook, Blogger, Nuzzel, Tumblr, or Instagram! The A&P Professor® and Lion Den® are registered trademarks of Lion Den Inc. (Kevin Patton) As an Amazon Associate I earn from qualifying purchases. I may be compensated for links to sponsors and certain other links.
Ya en mi experiencia laboral me he topado con alguna de estas personalidades ,dime tú también ? Vdd que sí
Allowing students to earn badges in the A&P course provides motivation to master all the concepts and also provides granular documentation of learning beyond the transcripted course grade. Host Kevin Patton shares his experience, along with a discussion of skin color in teaching future health professionals and the use of refresher tests to get students ready for their A&P course. 00:00 | Quotation 00:46 | Refresher Tests 08:49 | Sponsored by AAA 10:13 | Black & Brown Skin 19:48 | Sponsored by HAPI 20:54 | Badges 1: Digital Micro-Credentials 29:06 | Sponsored by HAPS 30:07 | Badges 2: Gamification 38:11 | Staying Connected If you cannot see or activate the audio player click here. Apply for your credential (badge/certificate) for listening to this episode. Please take the anonymous survey: theAPprofessor.org/survey Questions & Feedback: 1-833-LION-DEN (1-833-546-6336) Follow The A&P Professor on Twitter, Facebook, Blogger, Nuzzel, Tumblr, or Instagram! “That's what games are, in the end. Teachers. Fun is just another word for learning.” (Raph Koster) Refresher Tests 8 minutes A brief "refresher" on refresher tests, or as Kevin calls them... Test Zero. Pulling together ideas mentioned in past episodes, Kevin describes how he uses initial review tests in A&P 1 and a bit differently in A&P 2 to get students better prepared for their course. And he reveals the learning science behind why they work. Some previous episodes that mention Test Zero Teaching For Long Term Learning | Episode 7 The Syllabus Episode | Bonus | Episode 24 Promoting Academic Integrity in Our Course | Episode 25 Warnings & Safety Tips in the A&P Syllabus | Episode 57 The Prerequisite Problem | Wi-Fi Effects | Transplant Genomes | Episode 61 Sponsored by AAA 1.5 minutes A searchable transcript for this episode, as well as the captioned audiogram of this episode, are sponsored by the American Association for Anatomy (AAA) at anatomy.org. Searchable transcript Captioned audiogram Don't forget—HAPS members get a deep discount on AAA membership! Sign up for the new VDD or Virtual Dissection Database. You can access it at www.virtualdissectiondatabase.com Black & Brown Skin | Book Club 9.5 minutes A&P faculty have the awesome responsibility to "set the stage" for future health professionals. One way we can do this is to start early with an awareness of anatomic variations and how they influence observation of clinical signs. That that starts with the skin, particularly how common clinical conditions appear in a variety of skin colors. A new recommendation from The A&P Professor Book Club may help us (and our students) with that. Black & Brown Skin (Mind the Gap book) www.blackandbrownskin.co.uk/ Pulse Oximeter Devices Have Higher Error Rate in Black Patients (NY Times article) my-ap.us/3q0Gkg7 Racial Bias in Pulse Oximetry Measurement (letter in New England Journal of Medicine) my-ap.us/3jud132 Back to Campus Pandemic Teaching | Resilience | TAPP 74 (where Kevin talks about "setting the stage" in lion taming) Sponsored by HAPI Online Graduate Program 1 minute The Master of Science in Human Anatomy & Physiology Instruction—the MS-HAPI—is a graduate program for A&P teachers, especially for those who already have a graduate/professional degree. A combination of science courses (enough to qualify you to teach at the college level) and courses in contemporary instructional practice, this program helps you be your best in both on-campus and remote teaching. Kevin Patton is a faculty member in this program. Check it out! nycc.edu/hapi Badges 1: Digital Micro-Credentials 8 minutes Returning to the concept of badges (which are available for podcasts, book readings, seminars, etc., in The A&P Professor universe world), Kevin talks about the value of badges both for us as professional educators and for our students. The example of the latter is Kevin's use of badges in his Pre-A&P course. 86 | What a Year! | Pandemic Teaching & More | A Reflection (episode where I describe TAPP-ed badges) The A&P Professor Community (private online community with upcoming micro-course in micro-credentials) theAPprofessor.org/community (February 2021 subscription discount at theAPprofessor.org/Insider21 Badgr (digital micro-credentialing platform; free for basic badging functions) badgr.com Education | Professional Development (TAPP-ed page that describes & links to all the badges available in The A&P Professor Education program) Pre-A&P Badges | And Why Should I Care? (Kevin's student-facing web page for the badges he awards in his Pre-A&P course; list of badges & criteria; explanation of badges to students, including how to use them) lionden.com/fis-badges.htm Sponsored by HAPS 1 minute The Human Anatomy & Physiology Society (HAPS) is a sponsor of this podcast. 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Decembrī bija vērojams pret Latviju vērstu dezinformatīvu vēstījumu īpatsvara pieaugums kopējā pētnieku analizētajā materiālā, kas galvenokārt skaidrojams ar Valsts drošības dienesta (VDD) vēršanos pret prokremliskajiem medijiem “Baltnews” un “Sputnik”. Par pagājušā mēneša tendencēm dezinformācijas laukā ar Austrumeiropas politikas pētījumu centra (APPC) asociēto pētnieci Kristīni Skujiņu-Trokšu sarunājas “Delfi” žurnālists Ansis Īvāns. https://www.delfi.lv/atmaskots/raganu-medibas-baltiesu-gaume-vai-latvija-tiesam-vaja-krievu-zurnalistus.d?id=52765205
Das Weihnachtsfest wird in diesem Jahr anders sein als sonst – auch für Beschäftigte und das Ehrenamt. Das scheint festzustehen. Was aber können christliche Religionsgemeinschaften leisten, um Weihnachten sicher und gesund für alle Beteiligten zu gestalten? Welche Gestaltungsansätze können Verantwortliche, Hauptamtliche und Ehrenamtliche nutzen? Was hat sich in der Pandemie bewährt? Was davon kann in der Weihnachtszeit genutzt werden? In der Podcast-Folge 18 erläutern Frau Gabriele Marks vom VDD, Pfarrer Mathias Berger aus Mainz und Wolf Schmidt von der VBG die wichtigsten Vorgaben, Empfehlungen und Maßnahmen für sichere und gesunde Weihnachten in Gemeinden.
Fala Sociedade! Só na boa? Chegando mais uma quinta-feira com um MurderLIST para VCs! E hoje é Versão Brasileira, alguns sons que fizeram sucesso com bandas nacionais, mas que na VDD não são originais! Vem com a gente que o Episódio ta TOP!! Let's Rock Babe! 35 --- Send in a voice message: https://anchor.fm/murderonepodcast/message
What happens when you get master distillers from two largest rivaling brands together? Actually, some pretty good jokes. Fred Noe, Master Distiller at Jim Beam, and Jeff Arnett, Master Distiller at Jack Daniel’s, take the stage at Bourbon and Beyond to field questions asked by Fred Minnick. They talk about BBQ, celebrities, mash bills, the Lincoln County Process, and if Jack Daniels is actually a bourbon. Bourbon and Beyond 2019 will take place September 20th through the 22nd so if you want to be there in person to hear sessions like today’s podcast, go get yours at BourbonandBeyond.com. Show Partners: The University of Louisville now has an online Distilled Spirits Business Certificate that focuses on the business side of the spirits industry. Learn more at business.louisville.edu/onlinespirits. In 2013, Joe Beatrice launched Barrell Craft Spirits without a distillery or defied conventional wisdom. To this day, his team sources and blends exceptional barrels from established producers and bottles at cask strength. Learn more at BarrellBourbon.com. Check out Bourbon on the Banks in Frankfort, KY on August 24th. Visit BourbonontheBanks.org. Receive $25 off your first order at RackHouse Whiskey Club with code "Pursuit". Visit RackhouseWhiskeyClub.com. Show Notes: This week’s Above the Char with Fred Minnick talks about drinking in moderation. What kind of music have your brands been part of? What is your BBQ connection? What is the history of your distillery? What is your mash bill? What is your proof point off the still? What do you think of the Lincoln County process? How do you train your tour guides? Tell us about Gentleman Jack. Tell us about Jim Beam. Is Jack Daniels a bourbon? Do you ever feel competitive against each other? What does your average day look like? What was it like to hang out with Mila Kunis? What celebrities are connected to Jack Daniels? How often do you introduce new products? 0:00 Hey everybody. If you have a bachelor's degree and live anywhere in the United States, there's now a way for you to take your bourbon education to the next level. The distilled spirits business certificate from the University of Louisville is an online program that can be completed in as little as 15 weeks and will prepare you for the business side of the spirits industry. It's offered by the AA CSP accredited college of business. And this certificate was developed in partnership with industry experts to be one of a kind and it's going to prepare you for your next adventure. Learn more about this online program at business.louisville.edu/online 0:36 spirits Why is that? Why your barbecue sauce the Jim Beam barbecue sauce tastes so good. America's Got Jim Beam in it that's why 0:47 you made for it. And have you had the jab he had the jack daniels barbecue sauce. I'm sure they do. Um, no. I mean, if you had a VDD like Tyson Yeah. 1:00 add Whiskey and anything it's good for 1:16 everybody welcome back. This is Episode 214 of bourbon pursuit. I'm one of your host Kenny and buckle in strap up whatever it is because we've got a lot of news to roll through. Kentucky al has announced the release of batch number three rye this Kentucky out Kentucky straight rye whiskey carries a 10 year age statement and will be bottled at 114 proof in the press release Dixon dead man who's been on the show previously and episodes 27 and 160 has assumed the title of Kentucky Al's master blender, but he commented, there is a lot of older juice and right number three, but it's the 10 year old stocks that really give it that richer, thicker, syrupy mouthful and bring the blend forward. And as you know by listening to this 2:00 That the youngest whiskey in a blend is the one has to be shown in the label. So this will be making its way out to major markets across the US this month with a suggested retail price of wait for it $199 and 99 cents. Last week I had the opportunity of joining the fine folks over a liquor barn here in Louisville to select the very first of not just any barrels, but the very first barrels from a newly launched single barrel program. From bullet bourbon. We had the opportunity to tour the grounds and do some blending for fun. And during that blending process. There was one that just blew me away. I picked it up and I just knows that and I couldn't set it down. I just kept smelling this bourbon and I kept tasting and I told the master Blender whatever is going on here with sample number six. Just give me this single barrel and call it a day. Come to find out. They gave us samples of 20 plus year stencil well a stock that they had sitting around to just have some fun with blending. But you better believe I took no part in 3:00 lending that in savored every last drop. It was a tease, but a special treat nonetheless to have that experience with those folks there. Then we headed down to the barrel tasting room where we had different barrels and different bottles with different mash bills and different strains to come away with a total of three different barrels. And these will be available at liquor barn locations across the state of Kentucky in a few months, and I'll be sure to let you know when they do drop. Last week we had the opportunity to head over to Bardstown, Kentucky, where we were in a very unique opportunity to select two barrels of Elijah Craig from six that were rolled out. For anyone that has been on a quick pic before you know that three is usually the standard. We are fortunate that the heaven Hill team pulled some strings and got us a six barrel lot. We came away with an 11 and a 12 year old bourbon and both were just killer at barrel proof. But we also proved it down to us bottling proof of 94 just to make sure it's still held up and of course it did look forward to these going on sale to our 4:00 Patreon community in the upcoming few months, and a special shout out to keg and bottle in Southern California for making this all happen. Find out more about our barrel pics and what we have going on@patreon.com slash bourbon pursuit and you can find out more and get bourbon delivered to your door from keg and bottle go to keg the letter in bottle.com. And speaking of barrel pics, we had one go on sale this week, our riff you like a hurricane from new roof is going to be available to purchase to our Patreon community. Now you've heard it on the podcast already but we will be in Frankfurt at bourbon on the banks next week, August 24. Go get your tickets. We hope to see you there because we're going to have our own booth will be talking about bourbon pursuit. However, we will also be sampling our pursuit series for all those who haven't gotten the memo yet. And speaking of pursuit series, it's now official. We will be bottling our first Kentucky bourbon next month that will go on sale sometime in the October timeframe. And we're ecstatic to be the first time 5:00 let you know that we have partnered with Will it distillery to bring this experience to you? I know it's still surreal to even hear myself say that we're partnering with Will it and we purchased two barrels of their high rye bourbon recipe that will be bottled as pursuit series. Cats drink non chill filtered the works, you know how it is in this high recipe. It's not even available to liquor stores or distributors that are selecting their own bullet family private state pics right now. So we feel super excited and super lucky to be able to bring this as a one off offering of what we're able to do. And we selected not just one but two of these barrels two months ago and they just landed our bottling facility this week. We're going to be the first independent bottle of Willett distillate and who knows how many years and we've got more news to announce with this but we're gonna have to make you wait just a little bit longer until we cross our T's and dot our I's. Now today's podcast it was recorded last year at bourbon and beyond in 2018. 6:00 Since we were there, sort of in a passive capacity, we had one session, but we didn't have the ability to kind of record. We got this after the fact and that means we don't have any video. So if you're watching this on YouTube or Facebook, I'm sorry. It's like we're going back one and a half years before we started doing video. But if you're on the road or you're running or you're just listening to audio as usual, then just continue as normal. But as you know, verb and beyond is just around the corner. It's taking place next month in Louisville, Kentucky from September 20 through the 22nd. The festival has expanded from two to three days and you will get the chance to see a lot of familiar faces there. Ryan and I will both be moderating panels. And you've also got the entire roundtable making a presence. Jordan from breaking bourbon, Brian from sipping corn and Blake from bourbon are all leading their own panels and workshops. Of course, you're gonna have Fred Minnick there too. It's an opportunity to drink some bourbon, listen to some bands, go listen to a bourbon workshop or seminar then go back out there and rock out was the headliners. 7:00 This is covered in a single ticket price. So if you want to be there in person to hear sessions like today's podcast, go get yours now at bourbon and beyond.com. We'll see you in Louisville. Also, let's toast a bourbon to the weather gods and hope for no rain and clear skies this year. Now, let's see what Joe from barrel bourbon has for us today. And then you've got Fred Minnick with above the char. 7:25 Hey everyone, Joe here again. In 2013. I launched barrell craft spirits without a distillery and defied conventional wisdom. To this day, my team and I sourcing blend exceptional barrels from established producers and bottle a cast strength. You can find it on the shelves at your nearest retail store. 7:41 I'm Fred making this is above the charm. This past week in the Philippines, a lawmaker put forth a bill to ban the sale serving and consumption of alcohol and alcohol beverages and streets, pathways, plazas, alleys, sidewalks, parks and parking areas. They're building 8:00 leaf is is that this will be a proactive response in the growing problems of alcoholism in the Philippine. And this is a quote directly from a doctor, their alcoholism and violence have clearly become key public health issues that require urgent attention. Hence, it is imperative for the country to initiate a national policy to curb alcohol consumption in public places in quote. So here's the thing Philippines, this has been done before. And it didn't work, prohibition in the United States basically open the world to the mafia. And it also showed that it didn't really curb drinking at all. What it did do was it increased the sale of bad liquor, and people would die from drinking the equivalent of ethanol or gasohol. And today when we see areas where there are dry counties, you have moonshiners, so people will find a way to drink 9:00 And I'll also say this, that the efforts to ban alcohol or alcohol advertising, they're growing. And they're growing because we have never really been able to figure out as a society, how to drink responsibly. So, when you're getting your fellas together your girlfriends together, think about this for a moment, you could be an example used of drinking responsibly. What does that mean? Well, Google drinking in moderation, you definitely don't want to get behind the wheel. To me, a big part of drinking in moderation comes down to the taste. I like to sip and savor and analyze every single molecule that's hitting my palate. And that's been a big reason why I've been able to develop my palate using mindfulness techniques. I also believe that there's a project out there called the mocktail project that would be great to include in your parties that would help push the drinking in moderation and someone sober, doesn't want to have a drink. They can have a 10:00 mocktail that's basically a folk cocktail. That's just as tasty as the cocktail would. And of course, the culture. We live in a society that does not want to educate young people why they cannot drink until they're 21. I have a five year old and he can tell you exactly why he is not able to consume the same bourbon that his father and mother do. Now, I'm not saying that parenting is easy, but I do think it's important that we educate our children that alcohol is not the devil. It is not some evil thing that demons cast upon you and the only way to not be caught up in its evil spell is to avoid it. And all honesty, if we just teach our children that drinking is bad for your body until you reach a certain age and your body is able to handle it. To me that is a more appropriate and honest and truthful way to bring someone up in this world. But 11:00 It's just easier to band stuff. Just ask the Philippines. And that's this week's above the char. Hey, if you have an idea for above the char hit me up on Twitter or Instagram at Fred Minnick, that's at Fred Minnick until next week. Cheers 11:18 gentlemen please take your seats to my left here is Jeff our debt master distiller for jack daniels. 11:28 And to my other left, Fred noe master distiller for Jim Beam. 11:37 Gentlemen, it is such a privilege and honor to MC what is an absolutely historic seminar, jack and Jim, what's the difference? The two world best selling American whiskeys. This is awesome. Now, both of you all have had a lot 12:00 of musical connections. Tell us let's see what the difference is starting there. From the music perspective. What kind of music has Jim been been a part of? Well, I guess the first one was my dad met Hank Williams Jr. So it got a little name that's a little name drop right there. And you know we've played with McGovern Gentry for a long time country. And then we're trying to ease into the rock a little bit with Nickelback. And in our latest buddy was a kid rock. So we've, we've kind of hit different john years of music so you like people who like to drink? mostly people like to drink Jim Beam. All right. 12:46 All right, Jeff. Now, I think there's a musician that's pretty well connected the jack daniels. What's the history there? Well, if you go back in our history, it goes all the way to our founder who was pretty world traveled considering he was born. 13:00 In a small town in Lynchburg, Tennessee, so he purchased some instruments he created a group called the silver cornet band had them play on the square in Lynchburg because he learned that music and whiskey and kind of go together. They're both very social. So he's kind of solved the connection. So it began very early for us, but I think the game changer and jack daniels history was back in the 1950s when Frank Sinatra first held up jack daniels on stage, he called it the nectar of the gods. Our sales doubled from 1955 to 1956. But he was a lifelong jack daniels drinker. It was after that as you started to see jack daniels not just don't rock stages and music stages, but also in a lot of movies. But Frank was loyal to death. He literally was buried with a bottle of jack daniels in his casket. So we were honored to come out with a whiskey that that honored his love of the brand a few years ago. Now there's also some photos of like Jimmy Page, drinking. jack daniels backstage, the Rolling Stones. 14:00 Lemmy from Motorhead slash from Guns and Roses. These are people that are pretty iconic, you know in the rock world. And definitely love jack daniels and we have we're very fortunate we've got a lot of people in music who love jack daniels. And once we find that out, we don't feel like they should have to buy jack daniels t shirt, so I write a lot of letters and send out a lot of T shirts to people to thank them for their love. Now, Fred, jack daniels used to employ a guy who made sure that Frank Sinatra always had jack daniels. Has Jim Beam ever done anything like that? What do you mean my chili Goblin like? So there was a gentleman from our buddies right? Frank Sinatra. Never he always had a case of jack daniels nearby. So they employed someone who basically from what I understand, just basically drove around with him made sure he was always with jack daniels are we when people are on tour, whatever market they're in, our sales force shows up and breezes them pretty well. So your 15:01 I haven't heard any of them complain about not getting plenty of Jim Beam. Alright, so that's, that's just a little touch on the music about what's the difference between YouTube. You're also both really big into barbecue. really big into barbecue. Now Jeff, I was a judge with you last year at the big jack daniels BBQ. Tell us about your big barbecue connection is jack daniels. Yes, we the fourth Saturday in October. in Lynchburg. We sponsor what we consider to be the Super Bowl of barbecue. It comes very late in the season for the Kansas City barbecue society circuit. But it's the top 80 teams typically 20 of those have come from outside the US. So they're representing countries like Switzerland, Estonia, Canada, Australia, England, but usually it's about 50 or 60 of the best us teams who show up there to win the jack daniels international Invitational barbecue is a great time. I know and I have served as a judge on 16:00 The shade tree only where I judged the major meat categories, but I could hardly walk. When I got up on the table that day. I did not pace myself very well, but 42 samples in about three hours and you better know what you're doing. So I know we've got some judges out here in the audience today who were looking on who can attest to that. 16:18 Now, Fred, you are a great barbecue pit man. You're also a great ham maker. You've got a personal connection to barbecue and why is that? Why your barbecue sauce? The Jim Beam barbecue sauce tastes so good. Because God ZM Amen. And that's why 16:40 you made for it. And have you had the jab. He had the jack daniels barbecue sauce. I'm sure they do know I mean, if you had ever 16:49 seen it, do you like their Tyson? 16:53 whiskey and anything? It's good Jeffrey, what's wrong with you? 16:58 Does anyone 16:59 know 17:00 Go customer for was over. Yeah, well, I had a plus or minus, you know, I should have said we should have a cuss word counter out there with you. You know, are you sorry, I'm a potty mouth. We can trust Jeff to be a gentleman but Fred boy, he can get go. I'm not a scholar, so don't even go there. 17:18 Now both come from very historic distilleries. Very, very historic. Tell us about how jack Daniel got started. Well, for those who don't know jack daniels life story. He was orphaned at a very young age, so he found himself without either his biological parents when he was a young teenager. 17:38 He was one of 13 children born to his father, one of 10 born to his mother, but he ended up moving away to work for his room and board on a neighbor's farm. That neighbor was a Lutheran minister and a farmer. More importantly, he owned the general store that still stands on the square in Lynchburg today, and of course back in the 1850s and 60s, small town general stores had to serve a lot of functions. 18:00 And that community had to be a small scale department store had to swear you picked up telegrams, but also would be the pharmacy of the community. So jack started out making medicinal whiskey for a Lutheran minister that was sold to the townspeople of Lynchburg at the general store. So from very, very modest beginnings, he was out there for at least a decade perfecting the craft and ultimately bought the distilling equipment and moved it to where we are today and that happened in the 1870s. So you know, in jack daniels history, other than prohibition every drop of jack daniels has been made from a cave spring in Lynchburg, Tennessee. It's one of the things I think that makes us really special. It's one of the reasons why we're is I think, consistent as we are. It's a great water source and and the townspeople of Lynchburg have made it their passion to carry on the mission of jack daniels in his absence since he he passed in 1911. And since since we've been able to become the number one selling American whiskey today. So Fred, you guys also 19:00 Have a lot of your connection to your family's history is also connected to the water. Tell us about that. Yeah, our, I guess my great great great, great grandfather Jacob been migrated into Kentucky a little place called harden Creek. And they were given away land to get people to come this way from the northeast. That's how bad things were back then they were given land away, just to come in here and grow corn. Yeah. And what is now the Commonwealth of Kentucky. Jacob came down, got his parcel of land. He was a Miller of grain. Then he found out making whiskey was a good way to preserve preserve the grain. In fact, come to find out is whiskey making skills were better and more profitable than the milling of grain. So our family started making whiskey. Oh jacobin. And then as time went on, and railroad came through, his son moved it to Bardstown. Then prohibition came along shut off 20:00 is down 20:02 and along with a lot of other folks here in Kentucky, and after prohibition, Jim Beam started the old Murphy barber distillery backup spot right down here in Clermont, where he had been milling are grinding stone, limestone rock, there was a big spring there and a distillery. And so that's where we got moved from Harding Creek to Bardstown to Claremont, where we are today, and eight generations later, we're still there. So we're looking at both water sources. They're both limestone filter, they both very come from really strong natural areas of limestone, filtered x, you know, great access to the water. So we have a lot of similarities here. You know, from a cultural perspective, they're both very involved with music. They're both very involved in barbecuing, you've got some cool barbecue competitions as well. You both got barbecue sauces, and there's a lot of connections there. And then the water is pretty much 21:00 The same. Now let's talk about the recipes a little bit. Now, Jeff, I love you. You'll tell me exactly what your recipe is your mash bill, Fred, what's the Jim Beam? mash bill? How many years you've been trying to get that out of me for it. 21:14 I figured this would be the moment you would open up and share it. Not when I put me in that coffin, they might give it to you. I'm not going to give it to you because I know you want it so damn bad. It's true. It is I do want to bend the thing is Fred. If I gave you numbers, they ended up to 100 would you know if I was telling the truth? 21:34 I would make you put your hand on my book and swear it's the truth. So it's the book of bourbon. It would have to be the truth. wouldn't have to be shit. 21:46 fishes out for you. It has been a long time. It has been a long time. So let's just say that jack daniels is very sharing with their recipes. With now they share it and you guys been very protective of it for me for years. 22:00 But we can say that you're at least 75% corn. 22:06 You're more than 51% corn. Now we're more bitty 1% or then 51% corn. I'm not giving anything. Okay, because pretty soon as at how much raw, oh, you'll be able to figure it out but give you with this with the gentleman from Tennessee tell us from the mash mill recipe for jack daniels. I will you know, with the exception of the raw whiskey that we've just introduced, that's a 70% raw 18% corn and 12% malted barley pretty much everything that you've ever had from jack daniels shares what we call the old number seven rest, right? It's 80% corn is 12% malted barley and 8%. Raw. And I know Fred doesn't want to talk about it. But I would just say in general, jack daniels is about a half to a third of the typical raw content of a Kentucky bourbon. So when you start to contrast and maybe some of the differences, obviously whiskey and Kentucky bourbon that it begins at the grain, there was a deliberate choice to maybe go a little bit less on this 23:00 Ice that would be associated with Ryan going a little bit higher and corn and make it a little bit sweeter. So jack tends to push out into that sweet range a little bit. I think it's fair to say, I think I know your grain bill, but I won't tell anybody 23:12 with a brother, Jeff, you can say it here. No one's listening. No one's watching right now. They used to talk about it. 23:20 Actually, Chuck Cowdery had a good story about your dad and the issue of bourbon plus over there, you gotta go check that out. But sorry, so are our mash bills. The recipes are pretty close, you know, so they're pretty close to being the same them. And then let's look at the distillation perspective. You guys are both using column stills both using column stills. What are you coming off the still at what's your what's your proof point office Still, we we actually all of our stills are made out of copper. So there are columns still each is equipped with a blur, so it'll be a single pass but a double distillation process. We target 140 points. 24:00 roof and with the still design that we have, we can maintain that plus or minus one proof point. So we have a really tight range around our target. So 131 to 139 would be the range 140 is the target. What is your office still proof? Jim Beam? Yeah, that's where we'll change our taste is with distillation strength. But we go off the first distillation 125 second distillation 135. OK, so again, both very similar in distillation technique. And now med one med 132 to 140. And by law, they cannot go any higher than 160 proof. So that's actually telling you right there that they are deliberately going lower, so you can get some more of the characteristic from the grain in there. So they're both doing very unique things. And now 24:57 we get to that point where we start saying 25:00 A difference. Now, Fred, you you guys go and get Maple charcoal and filter your whiskey right before it right? No, wait, no, that's not Jim Beam. That's jack daniels. 25:13 Did you do any damn research before you? 25:20 Sometimes I apologize for my buddy here, you know, what do you think of the Lincoln County process? I mean, yeah, it's tradition. That's what I do. It's good. That's what makes them special. Well, do you like it? I enjoy what they do what they make. 25:38 So tell us about the Lincoln County process. And by the way, I didn't know I was trying to set 25:43 it up there a little bit. You know, even though Today we're in the second smallest county in the state of Tennessee, both by population and geography. You'll hear this charcoal Melling process often referred to as the Lincoln County process. So we're in Moore County, but don't get confused back in the 1860s lunch. 26:00 was in a larger county called Lincoln County. More county wasn't formed until the 1870s. But this was a regional variant of bourbon. It was just something that that popped up among local distillers and back in Jack's day, even though we're the only one you'll find there today. Back in Jack's day, there were dozens of different distilleries littered throughout the hills around Lynchburg taking advantage of the limestone water that we have in abundance there. But they began to charcoal filter 26:29 right after they would distill the whiskey and before they would put it in a barrel they would filter it through hard sugar maple charcoal became the variety of wood that was most preferred. People have asked me before the jack us any other different types of wood other than hard sugar maple and I wish I could answer that question. I think if he were here today, that's probably one of my top questions that I would have is what all did you experiment with before you settled there, but I will tell you this about hard sugar maple it's an indigenous word. It's all throughout the hills around Lynchburg. So it's it's a 27:00 easy to find, even after 150 years that we've been out cutting it and burning it for charcoal. The key advantage that I see from it is that it's a very low ash wood. And we're going Of course, we're going to take our whiskey through that. So we don't want a lot of ash coming out of the charcoal getting into the whiskey and going into the barrel. Today with modern technology, we could process that away if we needed to. But what I noticed is that there's really not much in the way of ash that comes off of it. So oak actually has quite a bit of ash. Maple does not so jack was not just known to use hard sugar maple in the charcoal mellowing process, but he felt that it was very important to change it frequently because he recognized that it was like a sponge and eventually a sponge will get full and get saturated. And so you need to do more than just pass through charcoal, the charcoal needs to be fresh enough to make a difference. So we're tasting our events every week, changing it out on the frequency necessary to make sure that it's making the difference removing the fatty acids cleans up 28:00 The grainy knows it comes off much lighter, sweeter on the foot, both on the palate and also on the nose. 28:07 Fred, I don't know about you, but I heard I listened to the process and I've seen it before a million times. And it just sounds like so much more work. 28:18 I mean, do you think that's why in Kentucky that they stopped using that process? We're just a little lazier probably 28:26 wouldn't have gotten around or in the 1700s. I mean, look at them. Oh, but I'm not really. But now. I mean, that's just that's what Jeff and them do. And I've always done it. So we use it. We used to do it in Kentucky. You know, the the bill distillers actually used to do a similar process in the 1800s. It just did not. It was not very popular here. And so it went away. We did some charcoal filtering after aging. Yeah, to kind of smooth out some of the whiskies back in the old days, but now we've done some different different techniques and filtering now 29:00 Your tour guides Jeff. They like the lumps and mortar rounds toward Kentucky. And they just say this makes us better. Kentucky bourbon. Yeah. Now I gotta say as a Kentucky and although I tried to be neutral and is my skin crawls a little bit when your tour guide start making fun of Kentucky now what do you trade? What he traded him over there? Well, of course I think it's friendly competition. I think it forces us both to be the very best at our game. And I think people when when we feel like we need to step up our game and mind our P's and Q's to make a better product. You know, I know that we've had people who've come and taking the tour jack daniels who've recently taken the Kentucky bourbon trail and some of them have come up and tell me that I asked the tour guide. They wouldn't say which distillery it was. But you know, why isn't that y'all don't charcoal mellow like jack daniels does. And the standard response you'll get is that all hail that's, that is nothing but a shortcut. And of course, I looked up shortcut. I looked up the definition of IO and it's amazing guy 30:00 was Fred know, well supposed to say shortcuts are supposed to save you time or money or both. And it's something that we invest days in that we spend over a million dollars buying wood and burning it and replacing it. So it's it's something we're pretty passionate about. But it's to Fred's point, it's one of those things that makes a Tennessee whiskey unique. It makes it worth exploring. The same way I think, you know, no, to Kentucky barbers are pretty much going to taste the same. This was something that was a regional choice to make Tennessee whiskey is different. And it's something that we feel like we perfected over the years and that we're pretty proud that we still do today. All right, let's go through our tasting here. The one on your lap if I'm correct, is jack daniels. My right so we can be? Yeah, the one on your left is jack daniels. For us up on stage is the one that's closest to you. Are you going to be You got it? 30:49 I got so we're serving here is a gentleman jack. Can you tell us a little bit about gentleman jack? Yeah, of course as a Tennessee whiskey, we charcoal mellow and we were talking 31:00 about that process being somewhat different than what they do in Kentucky to make a bourbon but that's right after we distill whiskey and right before we put it in a barrel, it slowly passes through 10 feet of hard sugar maple charcoal. So that's this is the distinct step that we do that makes jack daniels at Tennessee whiskey with gentleman jack. This was our first new whiskey since prohibition we introduced it in 1988. It was the only whiskey that we've ever done. We had charcoal melt it twice so it gets one pass of charcoal before it goes in the barrel it gets another one after it's been fully matured in the barrel and before it's bottle. So this is the double mellowed version of jack daniels. And what you'll notice about it is that it has a very distinct absence of oak finish. For people who a lot of times if people struggle with bourbon or with whiskies in general it will do it will have to do with the aftertaste of oak, some people find it pleasant, that's what makes them like bourbon for other people. It's a block. It's a reason why they can enjoy it. So gentlemen, jack was literally meant to be an approachable form of whiskey. 32:00 Using charcoal all natural this is. This is all water grains, barrel and charcoal. So there's nothing artificial added in here. But this kind of displays the art of mellowing by doing it twice. All right, Fred, what do you think? I'm Dyson idea. What do you been doing the whole time? I've been smelling that I All right. Yeah, that's fine. 32:21 I think I drank the whole damn thing. 32:25 That's bullshit. Yeah, when it comes when it comes to this one in particular, I often describe it as being very, very clean, 32:33 uncomplicated, but it has almost a citrus banana nose on it has an absence of the earthy wood notes in it. Very clean and light. The great Lincoln Henderson actually had a big hand in the development of gentleman jack he did Lincoln work for brown Coleman for 40 years. So between the people of Lynchburg and all the the whiskey making expertise we have at Brown Forman, which of course includes some great bourbon brands and now also scotch whiskey and a new Irish whiskey. 33:00 Brand we we cover the whiskey world pretty well today except with the exception of Japanese whiskey. We even have Canadian. So we're a whiskey company at our core. So Lincoln Henderson is the founding master distiller for both angel's envy and Woodford Reserve. He's in the bourbon Hall of Fame he passed away in 2013. great man. So there's a little bit of a bourbon iconic figure connected to that whiskey now let's taste a little bit of Jim Beam here. This is the this is the one we see Mila Kunis talking about all the time. 33:33 This mask about you know the person this is the world's best whiskey their words not ours, according to see. Yeah. So what let's look at the Mila Kunis and a little bit but tell us about what we're drinking here with the Jim Beam black champion. Black is our gym being Nashville. Which I'm not going to tell you Fred. I know. 33:57 You're not one. But we do. We aged long. 34:00 RGM been white label stays in the barrel for years. This is a six year taste profile. So we're putting barrels that are older than six, some that are six, and some are a little younger than six. That way we keep the product on the shelf with a domain curve. All right, I got it. I got interrupted here. I gotta interrupt you. Okay, there wasn't once upon a time it had an eight year old age statement on there. If you go back farther, it had 101 months. 34:29 History he was ready for me damn right. 34:32 Fred you remember we've done this ship before? Yeah. 34:36 You ain't sent me out man. I might. 34:39 I might look dumb, but it's just a disguise. 34:43 I still you know, the thing is, it took me a while to get over by still buy it. I'm glad to see it. But the big thing on this ad it's 86 proof. So it's got more age, higher strength. So gets a little bit more of what and I think bourbon is all about no more word. 35:00 Which I did notice gentlemen jack doesn't have that much wood on the nose and finish. But I mean if you want a little more the if you like the oak, then you know the Jim Beam black is more than the GMBYI Let's take a taste. You didn't do that good talking to you in the jack daniels Did you? Yes sir. Oh you did I miss that. You want to watch it? Should you always try to set me up? I'm not trying to set you up. So now here I am trying to set you up. You're setting me up. Here we go. No, I'll give you the my spiel is a drink thing. I'm drunk enough to give me that loaded. Sorry. 35:34 Is jack daniels a bourbon? 35:39 Hey, it's Kenny here. And I want to tell you about an event that's happening on Saturday, August 24. Because I want to see you in historic downtown Frankfort, Kentucky at bourbon on the banks. It's the Commonwealth premier bourbon tasting and awards festival. There's live music and over 100 vendors of food, beer, wine, and of course, bourbon. But 36:00 Guess what even will be there in the bourbon pursuit booth. You can check out all the events including tastings with the master distillers that you've heard on the show before and the People's Choice Award for the Best bourbon out there. You can get your all inclusive ticket for $65. Plus, you can join on the free Friday night event. Go and check it out. bourbon on the banks.org there are more craft distilleries popping up around the country now more than ever before. So how do you find out the best stories and the best flavors? Rock house whiskey club is a whiskey the Month Club and they're on a mission to uncover the best flavors and stories that craft distilleries across the US have to offer. Along with two bottles of hard to find whiskey rackhouses boxes are full of cool merchandise that they ship out every two months to members in 40 states and rock houses June box they're featuring a distillery that claims to be the first distillery to stout a whiskey rackhouse whiskey club is shipping out two bottles from there, including its beer barrel, bourbon and beer. 37:00 barrel rye, both of which were finished in barrels that were once used to mature America's number one selling bourbon barrel aged out. And if you're a beer guy like me, you would know that's New Holland dragon milk. Go to rock house whiskey club. com to check it out and try a bottle of beer barrel bourbon and beer barrel rye. Use code pursuit for $25 off your first box. 37:24 Is jack daniels a bourbon? 37:26 Well, no, I mean, let's look on the label. You see the word BOURBON on her anywhere. It's in the North American Free Trade Agreement. 37:36 I political Oh, man. 37:40 Come on. JACK. Is jack daniels a bourbon? You know, according to NAFTA? Yes, it is. Oh, there we go. Thank you so much for coming. If you want to trust if you want to trust the view of our government, you know, you'd have to say that it is if you want to make your own decision about that. That's fine too. But if you look at everything in the federal 38:00 codes that define what a bourbon whiskey is. There are no exceptions when it comes to what jack daniels is our grain bill in the fact that were made in America, our grain bill, our distillation proved the fact that we only use new barrels or even make barrels for ourselves as a whiskey company. The only way to do that there's nothing that would disqualify us. But there's always been this argument that well, if you go to charcoal mellowing, it does distinctly change the spirit. Yeah, it changes the nose. It changes the mouth feel of it. And the actually it was the US government. Back in 1941. Who petition jack daniels This was after prohibition it ended. They wanted us to change our label from jack daniels, Tennessee whiskey to bourbon, they were trying to kind of go around and clean up who's operations and what they were being labeled as and they said, we've looked at your process. There's no exceptions. The what defined is bourbon, so why not just re label yourself so they submitted samples before and after charcoal mellowing, my salespeople actually offer those educationally today. 39:00 And they tasted it. This was the alcohol Bureau in Washington DC there actually was such a thing back then they tasted the product. 39:08 Government, they wrote us a letter, and 1941 that basically says we've tasted your product. And we have to agree that you don't have the character that's typical of bourbon whiskey. Therefore, if you want to label yourself a Tennessee whiskey, we won't contest it any longer. And of course, the US government has a way of changing their minds. So we can we've kept a copy of that letter just as evidence that we don't want to revisit that. We feel like the arguments been one. But we all we also say that it gives us hope, because it's the one evidence that we have in the last 75 years that our US government got any decision right. So we take that one 39:44 political angle. 39:46 You don't get me in trouble jail. Fred, I know is going to get me in trouble. So Jeff, 39:54 do you ever get tired of people asking you that question? Is jack daniels a bourbon? No, no, no. 40:00 Really I think as long as people are curious, that's part of the battle. You know, for the longest time whiskey from the 1950s and 1960s and 1970s whiskeys were all the rage. You know, the whiskey cocktails were what people ordered. But then we saw some pretty lean years as whiskey brands, the 70s, or the 80s 90s and 2000s. Were not necessarily so kind. So I think just having people to be bourbon curious. 40:26 Whiskey curious. 40:29 As part of the battle, you know, I always say if we can make whiskey interesting, collectively, but the rising tide will raise all ships. So I feel like jack daniels success doesn't necessarily have to come at the expense of Jim beam's. And I think probably Fred would say the same. That we can both have extremely successful brands because we we do have unique flavors, we have unique brands. And that's going to appeal more or less to different individuals. But I think just having people be curious about whiskey is the biggest part of the battle if they're open to trying it. I think they're 41:00 Something in the whiskey category that are going to like, all right, Do you guys ever feel competitive against each other, like you want to own the well over the other? 41:10 You know, the thing that, you know, the guys in production, were buddies, sales guys on the street. That's another damn store. 41:21 I mean, I'd have to agree. You know, Fred. Now, this is very rare that we would be on the same stage together. But we met about eight or nine years ago, in Berlin. It was amazing, because I think that was Fred's first comments. That means like, we're a state apart, and we had to come all the way to Germany to even meet. So we, we were at the Berlin bartenders convention and had a chance to actually we were representing American whiskey versus the other categories of global whiskey. So we decided against the devil Yeah, instead of having the fence between us. We were actually on the same side of the fence there. So we were we were in violent agreement I remember about the importance of limestone water and mixing up grains and using new 42:00 barrels, making it all natural not using colorings or flavorings and things of that nature. So, you know, there's so many things that are common about Jim Beam and jack daniels, of course, the one variant being charcoal mellowing, and people can decide if that's right for them. But I think as long as they're willing to to order a whiskey, there's a good chance that they're going to like something there. There we were, essentially, Jeff and me against the world. I don't think we did pretty damn good. 42:28 Well, we were lucky, because it was in Germany, and Jim Beam is pretty strong in Germany. And so all our sales people were kind of on one side and they were probably a little drunk. I think. 42:41 I think there's one thing we could agree to I actually have some friends who are what I call Doomsday errs, you know, who created fallout shelters who got Mr. ease and, you know, bottled water stacked up to the ceiling. And a lot of them have basically told me that I'm not I'm not hoarding cash. I'm basically putting bottles of jack daniels. 43:00 Whiskey and stuff like that because if the currency fails, they're absolutely certain that a bottle of whiskey is always going to be worth something regardless of what happens. 43:11 But but but Baka would not be. Yeah, I think if we go back to bartering, it's gonna be good to be in the whiskey business. What do you say? 43:19 Bam, right? You get more with a bottle of whiskey and you can handle the money. I guarantee it. 43:27 Well, gentlemen, it's been a real pleasure here. This is such a rare opportunity to have these two on the stage. I would actually like to take some questions from the audience how bad it would you like some light shirt from folks like that some questions? 43:42 Anybody have any questions out there? 43:45 What is a regular day for Fred? No. And Jeff Barnett. 43:51 I get up about 630 here down the August 1 thing, look at emails is like every other person. So do 44:00 Deal with meetings conference calls. And then I get to have fun and go down to the distillery. taste a little white dog right off the steel and then usually hit by the lab and taste some as liquor and then hang out at our visitor center, shake hands, take pictures, sand bottles, and then hit home but then the day they send me to 44:25 your liquor stores and bars, all days signing bottles, taking pictures, doing presentations, I'm sure Jeff's when he's on the west side. I'm usually on the east. 44:37 That same place. 44:39 You can see who's been ahead of you when you go into a liquor store. You see bottles on the shelf that have been signed by Jeff Arnett or Jimmy Russell or whoever is it well shit, I'm definitely behind him. You know, don't put dates on them so you don't know. Or maybe x coming. I'm not going to store and see bottles son from the last visit. And I think what shipping 45:00 Selling enough 45:04 one too many 45:06 I got out they don't let you get away. You know I think the the one word in that question that that puzzles me the most is regular I don't know that I've ever had a regular day as a master distiller because every day is it's different to me I feel absolutely blessed to work for jack daniels you know I'm a native Tennessee and argue that is probably the best known product from our state so have to have any hand in working at jack daniels to me was a dream job. But 80% of my time is spent in Lynchburg. The one thing that I'm most fortunate about is that I don't have to travel between facilities we make every drop in one spot using a water source which allows me to keep everything as consistent as I feel like it needs to be. It allows us to leverage you know, employees who have you know, several generations of experience making whiskey I think that I'm not the strength of jack daniels it is the people of Lynchburg who've committed over the years since prohibition to 46:00 Keep the brand going and growing. But I do spend about 50 to 60 days a year out on the road. So, you know, you become a little bit of a 46:09 celebrity in the world of whiskey. You know, it's amazing what passes that celebrity, you know. But you know, to to a whiskey fan, they want to meet you, they want to get a photo, they want to get a signature. And that's it's always an honor to do that. But we are sold in 170 countries today in 10 years. I've actually by the end of this year, I'll have visited 39 countries so cover a lot of the ground in a few days of the year. So let's talk about celebrities for a second. Let's go to what's it like spending time with Mila Kunis? My one man 46:41 I mean, it could have been worse, you know? Now Mila she she came here to Kentucky a couple times and we hit it off right off the bat. You're gonna love this story. I might as well go on and tell it. Surely I won't get any trouble since I've already cursed a little bit going on with Mila first came. They wanted to make sure that our first 47:00 meeting was on film. They didn't want us to get to know each other. And so she came to our home there in Bardstown. She was in the house. They were getting her hair and makeup wardrobe. You know, I pretty much do all that stuff myself. I don't I don't have hairdressers that go with me, kind of no reason to me anyway. My wife went into the house and was talking to me over there and she had her dog when Mila and her boyfriend at that time, Ashton Kutcher had to put her dog sleeping on Neil or something. So she got pretty emotional was holding Sandy's dog. And she said, I'm a little nervous to work with your husband. And Sandy said, Why? She's a walk curse a lot. 47:45 And my wife said, You're good. 47:48 She's a no you don't understand. I say fuck a lot. 47:53 She said, You're still good. 47:58 Sandy came out 48:00 And she came on was laughing I said, What's the funny? So Amelia is nervous to work with you. I said Why? She was he causes a lot, so it's no big deal. I know what she's worried about saying fuck around you. So we did our little meeting. It was on film, everything was cool. Cut, take a break. I got her ear and I said fuck it. 48:22 We're gonna get along just fine, big boat. 48:25 That's how I was. I was tell someone that after having met Fred I realized he was truly a master of the English language because he can take the F bomb and use it as every form of the English language in one sentence. 48:40 Yeah, all right, Jeff, as I play bartender here on stage, why don't you tell us one of your celebrity stories? Oh, goodness. Um, you know, we're very fortunate. Like I said, we've had a lot of people especially in the music industry. We were fans of jack daniels. So especially in country music, a lot of people and they think of, of Tennessee. If they don't 49:00 Think of jack daniels when they think of Tennessee I think they largely think of country music so I've had a chance to spend time him he 49:08 music table we even work, you know had a chance to hang out with with Zac Brown and 49:14 and his wife and his children and also now with Eric church, and to find out that his wife literally grew up about 30 minutes from my hometown, and what real and really good people that they are. I think that I think that's the most surprising thing that I find is that celebrities are not a lot different than we are, you know, some of them maybe are but the ones that I've had the privilege of meeting I've been always really surprised at just how humble and what good people they are. And of course if they love jack daniels even better, we got plenty to talk about if they do. I know you. You are partial to the ones that favor Jim Beam and I definitely have a I feel like a big fan base out there both in Hollywood and all over the music industry, jack daniels as well represented there. All right, everybody. Let's have another question. Who's got a 50:00 Question out here. Yes, ma'am. Right here in the back. coming to you with the microphone. 50:06 How often do you introduce new products? And when will your next one be introduced? 50:12 I'll answer for jack daniels. You know, how often do we come up with new products? You know, for the longest time we didn't, we had one brand that carried us for over 100 years. We introduced gentleman jack in 1988. We introduced single barrel in 1997. We didn't introduce any new products from jack daniels for about 14 years. And that wasn't necessarily due to our lack of interest of offering new products. It was really more about is the market even wanting a new product from us? Are they happy with what they have, but as as whiskey has taken off again, I think that's what we're seeing has changed the most is that people do want to try a lot of different things, including the loyal jack daniels people and that includes, you know, our newest grain bill that's come out is raw. So we have two different versions of it to me that's that's our new product and for this year, that's what we're going to continue to focus on. 51:00 Because to me, I think it's very different for people who maybe have never been a fan of jack daniels before. Maybe one of the reasons is the fact that we're very low and raw. And if you do like a high raw whiskey, we now offer that, you know, jack daniels, you know, like I said, we're very fortunate we have just a rabid fan base. And I think besides Harley Davidson, we just recently got named the brand that's most likely to be tattooed on someone. So, you know, people have asked me why, why did you come out with a rye whiskey? And it's like, well, my fear was that there's going to be this big burly guy with a tattoo that says jack daniels on his arm, and he's gonna taste rye whiskey this out. He really likes that. So we need to give him a jack daniels option. That way, he's not going to have to go and get his tattoo taken off. So but you know, to answer that question, we've come out with one new product a year for the last seven years. So we've gone from three to 10 in a really short period. So we're just kind of trying to maybe decompress a little bit from doing that and focus on what we've got out there. We feel like we've got a really strong profile. 52:00 There's something in there that out of those 10 that I think everyone's gonna like. 52:05 Now you were about to dispute the tattooed thing for No, no, no, no, I asked him. I was going to ask Jeff for his was, oh, I couldn't show you on stage. I'm sorry. 52:17 Between me and my wife, you're lucky, you're lucky. 52:21 Now, we do a lot of innovations. 52:26 My son actually, Freddie, he's he's got a project who just had a baby, by the way, or his wife had a baby. Right? Congratulations, grandpa. 52:36 Paul, I was holding Booker last time. 52:39 It was kind of cool. But Freddie's got a brand called Little Book, which so my father called him from the time he was a baby. So every year, he's going to make a straight whiskey or straight spirit blend. And so every year it's going to be another chapter into chapter one was 52:59 either 53:00 No easy. The second one's no easy task. First one was the big easy, but he's taking spirit streams from within the beam Suntory portfolio around the world, which he's got a pretty unlimited canvas. When you look at all the whiskies we have which, with this year, he did a 40 year old Canadian 16 year old Canadian rap, an eight year old, Kentucky straight raw, 53:24 all cash strength, just like his grandfather. And so we're doing innovations, probably one or two a year. And then we'll within our play knob Creek will go we've done single barrel rise, single barrel Bourbons, can strength. We do different things, all limited releases, because folks like Jeff said, they want different stuff. They don't want the same thing over and over and over. If we see something that really hits hard, like we did a base right and dark raw, which was, oh, I've got an idea that we could maybe execute for next 54:00 years festival Why don't we do a blend of jack daniels and Jim Beam for bourbon and beyond 2019 54:09 I go say won't ever 54:12 talk somebody 54:15 and they'll tell you what how drunk were you to when you agreed to 54:23 have your people talk to my 54:26 so you get this ball rolling Fred 54:29 should we have it for next year? 54:34 I would say this so I think it when you're looking at Tennessee and Kentucky you're definitely looking at some of the world's best spirits when it comes to whiskeys and you can't go wrong if you will explore around I think you're going to find there's something they're just gonna like. Oh yeah, for sure. So what you're saying it's better than Canada. 54:50 Well, it's different than Canada we have different rules. We have Canadian whiskey brand is 54:56 people like and more power to them. We got scotch whiskey brands. 55:00 get us in trouble. Yeah, we got Canadian. You know, I've recently become a fan of shared scotches oh you know students don't smoke repeat but I'm open to trying new things. 55:11 Well gentlemen, if you all if anyone in the audience has anything lab, I know you to do. I just poured you like four fingers there. Grab what you have a lap. Let's toast it to, to Fred know and Jeff Barnett chairs and now you all 55:28 chairs Transcribed by https://otter.ai
Stichwort Drehbuch - Der Podcast vom Verband Deutscher Drehbuchautoren (VDD)
Auf dem Filmfest München bot der Verband Deutscher Drehbuchautoren den Gästen ein Panel zum Thema "Die Kinokrise und die DrehbuchautorInnen". Teilnehmer waren Sanne Kurz (MdL Bayern, Die Grünen), Carolin Otto (Drehbuchautorin, VDD, FSE-Vizepräsidentin), Thomas Negele (SPIO-Präsident), Christian Pfeil (Geschäftsführer Filmbetriebs GmbH München), Sebastian Andrae (Drehbuchautor, gf. Vorstand VDD) und moderiert wurde das Gepräch von Brigitte Drodtloff (Drehbuchautorin, Vorstand VDD).
Você ai que chegou na vida adulta mas não sabe o que fazer, está na faculdade mas não sabe o que quer mas tem certeza do que quer fazer na vida mesmo não sabendo o que a vida é? Mas mesmo sabendo ainda não sabe? Você está no lugar certo! Olá, meus bons! Hoje iremos falar sobre as aventuras e dificuldades que temos logo quando chegamos na Vida Adulta, especialmente com o choque de realidade que vemos desde a nossa infância: O que queremos ser quando crescer? Mas quando bate aquela crise existência sobre o que quer ainda ser e o agora mas não sabe?Mas sem preocupações a mais para você! Venha descontrair e refletir de forma bem descontraída! E que sabe não nos encontramos no Tibet?! Quer livros mas não tem dinheiro? Tem dinheiro mas não tem desconto? Seu problemas acabou! VDD e Saraiva oferecendo esses descontos de montão! Lembrando que o cupom dura até dia 31 de Maio de 2019 e os demais links até dia 27 de Maio! E-Books com até 30% de desconto clicando aqui!Box de Sherlock Holmes, Edgar Allan Poe e Segunda Guerra Mundial com até 80% aqui!Centenas de livros fantátisco por até R$10,00 clicando aqui! Nas compras a partir de R$89,90 ganhe +20% de desconto confira!Não sabe o que comprar de presente para sua namorada/namorado? Compra um livro com desconto de até 70%! Confira agora!Acha pouco, toma aqui esse cupom que dá 15% de desconto: LIVRARIA15 Sugestões? Ideias? Histórias pessoas? Mande um e-mail: viagemdodesconhecido@gmail.com Acesse o site: viagemdodesconhecido.com
After a few months without a Very Disco Discovery volume, starting being too much for all the loyal listeners and fans, even for LAGANT him self. There is a lot in mind to spread and share! So here it is the first of the three the podcast sessions for this July, full of VDD content. Enjoy it! Tracklist: 00:00 Blondie - Rapture (The Reflex Revision) (2014) 05:00 FLUSH - Never Stole Nothing (2016) 08:10 Hypnolove - La Piscine (Voilaa Remix) (2016) 12:37 Superlover - Retroverb (2016) 16:20 Jessie Andrews - I Never Knew (2013) 18:04 Snacks - Deep Fry (Fouk Remix) (2016) 22:33 Antonio Giacca - Drop That Booty (2017) 26:19 Pirupa - Get Funky (2010) 32:13 Roisto - Switch (2017) 35:13 The Fog - Been a Long Time (Gio´s Dope Mix) (2013) 40:34 Ben Westbeech - Same Thing (Chocolate Puma Remix) (2012)
Stichwort Drehbuch - Der Podcast vom Verband Deutscher Drehbuchautoren (VDD)
DrehbuchautorInnen werden immer noch nicht angemessen in der Öffentlichkeit repräsentiert. Ein Panel des VDD auf dem Filmfest München hat das Thema in den Fokus gestellt. In dem voll besetzten Saal diskutierten, moderiert von Brigitte Drodtloff (Drehbuchautorin, Vorstand VDD), die BR-Redakteurin Dr. Cornelia Ackers, der Bavaria-Produzent Ronald Mühlfellner, Dr. Christian Bräuer, Vorstand der AG Kino, Doron Wisotzky, Drehbuchautor und Leiter der Sektion Drehbuch an der HFF München, Dr. Lisa Giehl vom FFF, und Sebastian Andrae, Drehbuchautor und geschäftsführender Vorstand VDD.
En "Onda de Misterio" trataremos hoy un tema especialmente inquietante: Los visitantes de dormitorio (VDD). ¿Fantasmas? ¿seres de otros mundos?. Lo debatiremos como siempre en compañía de Emi Vozmediano, Francisco Mora Gomez, Benjamín Hernández y Antonio Ruiz
Kinofilme zu finanzieren ist in Deutschland ohne Filmförderung fast unmöglich. Dabei sind die gesetzlichen Grundlagen in einem ständigen Fluss der Novellierung. Carolin Otto berichtet hier aus der Praxis der Drehbuchförderung bei der FFA. Katharina Uppenbrink spricht darüber, wie sie im Auftrag des VDD für eine angemessene Berücksichtigung der Autoren kämpft.
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