Podcasts about ct1

Take 10 with Tim – March 28, 2025 at 9:30 am ET, 8:30 am CT1.Observations from the first day of games?a.Did anything in particular performance stand out?2.Kind of like Kristian Campbell, it just seemed like Cam Smith was going to go North with the Astros – Actually more West, as Houston is well west of West Palm Beacha.Stat line for 2025 – AB, HR, RBI, and BA3.Other interesting spring training decisionsa.Brett Baty wins the starting second baseman for the Mets. What are your thoughts on him this season? He had a great spring.i.Luis Ángel Acuña made the Mets as a super-utility player. Any interest?b.With Zack Gelof undergoing hamate surgery, Max Muncy (the other one) appears to have secured the second base job. Any interest?c.Ben Rice made the team. He hits the ball hard, but will he get enough playing time?d.It has been reported that Mookie Betts had an illness that caused him to lose 25 pounds. He wasn't that big to begin with. If all this is true, fantasy managers might want to brace for some early power struggles. Your thoughts?4.Cy Young, MVP, and ROYa.Your Choice for AL and NLb.Your sleeper choice for AL and NL5.AL Playoff Predictionsa.Three divisional winnersb.Three wildcardsc.Jump up team – Who surprises and sticks in longer than people think6.NL Playoff Predictionsa.Three divisional winnersb.Three wildcardsc.Jump up team – Who surprises and sticks in longer than people think7.World Series Competitors – AL and NL 8.Who wins the World Series?9.What hitter are you targeting for this week's FAAB?10.What pitcher are you targeting for this week's FAAB?

Super Trowel 2025 Trade Legends Exclusive | THE UK'S BEST BRICKLAYING COMPETITION is backThe boys from Super Trowel have returned to the studio for round 2. Earlier this year, the guys headed over to Vegas for the Spec Mix bricklaying 2025 competition - the biggest bricklaying competition in the world.The guys took the winners from Super Trowel 2024 bricklaying event to go up against the big boys of the USA, hoping to finally put TEAM GB on the map!Jack and Joe break down last years Super Trowel event, and explain to Mark @MJTiffPlumbing how the 2025 competition will be even bigger.#construction #bricklaying #podcast00:00:00 Introduction00:09:49 Super Trowel 202400:27:53 VEGAS, BABY!00:37:41 Losing Loved Ones00:48:22 Super Trowel 202500:55:00 Tool TheftGuests this week: Jack and Joe @SuperTrowelOfficial Kyle @kbricklaying (Insta)Hosts:Mark @MJTiffPlumbing ⭐ Proudly Sponsored by CT1 | www.ct1.com | @ct1ltd ⭐ Supported by Tradify | https://tradifyhq.com/ | @TradifyHQ

In this conversation, Russ and Nicola discuss various aspects of the construction industry, focusing on the importance of community, mental health awareness, and personal journeys within the trade. Find Nicola here https://www.instagram.com/nwalsh30?utm_source=ig_web_button_share_sheet&igsh=ZDNlZDc0MzIxNw== Follow CT1 https://www.instagram.com/ct1sealant?utm_source=ig_web_button_share_sheet&igsh=ZDNlZDc0MzIxNw==They explore the challenges faced by tradespeople, particularly regarding mental health, and emphasise the need for open conversations. Nicola shares her background and experiences in marketing for CT1, highlighting the brand's commitment to supporting the trades community. Nicola discusses the importance of organic promotion and community engagement for the CT1 brand, emphasising the role of social media and influencer marketing. She shares insights on the challenges of maintaining brand resilience amidst competition and the stress it brings to family-run businesses. The discussion also highlights the significance of self-care, mental health, and the importance of community support within the trades. Nicola reflects on the need for empathy towards tradespeople and the impact of tool theft on their livelihoods, advocating for greater awareness and support for the trades community. They discusses the pervasive negative perceptions surrounding tradespeople and the construction industry, emphasising the importance of positivity and mindset in overcoming challenges. They reflects on Their personal growth journey, highlighting the significance of self-development and the tools one can build to navigate life's difficulties. The conversation also delves into the mental health crisis within the construction sector, exploring the unique pressures faced by tradespeople and the need for community support. Russ advocates for kindness and compassion, urging individuals to be more supportive of one another, especially in challenging times.

E96 | Why Electricians In Social Housing Are Paid The Least Money! Kimmy never planned on being an electrician in construction, but after seeing what electrician installers were earning at the business she worked at.. she decided she wanted a slice of that rather lucrative pie! After being allowed to shadow the installers, she enrolled at College to obtain her electrician qualification, but realised she'd need an apprenticeship. Unable to find one locally, she thought of a way to not only get one, but make good money in the process. Kimmy goes on to describe her career as an electrician in the trades, including what really happens when working in Social Housing, how she was awarded the On The Tools 'Electrician of the Year' 2024 award, and how she is able to comfortably work only 2 days a week due to her social media earnings. Guest this week: Kimmy @kimmythesparks Hosts: Alex @alexinsley ⭐ Proudly Sponsored by CT1 | www.ct1.com | @ct1ltd ⭐ Supported by Tradify | https://tradifyhq.com/ | @TradifyHQ

E85 | TERRIFYING GHOST STORIES | UK,s No.1 Paranormal Investigator Danny Moss Tells all "Strap in Ladies and Gentlemen... this could be a long one." - MJ Tiff. Join us for our spooky Halloween Special as we sit down with one of the UK's leading Paranormal Investigators - Danny Moss @TheParanormalInvestigator for some Ghost Stories. Danny's ghost hunting adventures started at a young age, after experiencing a paranormal event that couldn't be explained. Since then, he has been on a ghost hunting mission to explain the unexplainable and debunk all things paranormal....until its real!!! Using a scientific approach, Danny aims to distinguish between fact and fiction, as he knows that the public have had their fair share of Ghost Hunting and Paranormal shows, such as Most Haunted, Ghost Hunters, Celebrity Ghost Hunt and Ghost Adventures. He has toured both the British Isles and America with his expert ghost hunting team, capturing some truly unbelievable experiences, all whilst filming for various shows such as Paranormal Captured, The Haunted Hunts and My Haunted Hotel. So sit back, get your popcorn, draw the curtains... and as Macaulay Culkin once said "This is it. Don't get scared now!" Guests this week: Danny Moss @TheParanormalInvestigator Hosts: Mark @MJTiffPlumbing ⭐ Proudly Sponsored by CT1 | www.ct1.com | @ct1ltd ⭐ Supported by Tradify | https://tradifyhq.com/ | @TradifyHQ

E83 | How to START A BUSINESS in Construction and keep your APPRENTICE! In this episode of the Trade Legends Podcast we chat with Jamie and Robbie about their journeys into the construction industry. Jamie always wanted to work with his hands, but in order to run and grow a successful construction business, he learned that coming off the tools was the only way to bring this about. Robbie, his young roofing apprentice, has been with Jamie for a couple of years. Robbie sees Jamie as an onsite mentor; a man who can teach him how to start a business, about working in construction, and how to adopt a good work ethic. Get involved in the topics that are discussed, including the state of the education system, how to start a business, and how to use social media as part of a wider marketing strategy. "Train people well enough so they can leave...but treat them well enough that they'll stay." #construction #startabusiness #apprentice 00:00:00 Introduction 00:01:55 Jamie's Story 00:26:15 Expanding the Business 00:35:20 Robbie's Story 00:43:16 Apprentice of the Year 00:47:45 Changing your Mindset 00:50:14 Starting the Podcast 00:51:32 Future Plans and Final Thought Guests this week: Jamie and Robbie @TaylorTalksTrades / @TaylorRoofs Hosts: Alex @alexinsley ⭐ Proudly Sponsored by CT1 | www.ct1.com | @ct1ltd ⭐ Supported by Tradify | https://tradifyhq.com/ | @TradifyHQ

In episode 3 we are joined by Dr Serina Sidhu, an anaesthetic CT1 about to start her obstetric novice period. Rosie and Eoin are here to answer her questions about the role of the anaesthetist on the labour ward and what we actually do on a day to day basis.  References - -        OAA Obstetric QRH - https://www.oaa-anaes.ac.uk/oaa-quick-reference-handbook/qrh -        Anaesthesia (e-LA) -> Core Training - Clinical -> e-LA Module 04a - Obstetrics -> 07 Serious problems in obstetric anaesthesia

HOW TO GET INTO PLUMBING & becoming my own APPRENTICE Like most young people, Dave @boilerstobathrooms6267 had no idea what he wanted to do as a Career or hat to be an apprentice in. Luckily for him, his mother was prepared for such a situation - "Plumbing David, it pays well!"...so a plumbing apprentiship it was. It wasn't, however, as simple as that, plumbing it was. Dave struggled to find a plumbing Apprenticeship in the local area; something that he would require in order to become a fully qualified Plumber and Gas Engineer in the construction trade. "Well..." David thought, "Perhaps I could become my own Apprentice." Now, that might sound like something thought up during a drunken stupor, however it was exactly what Dave would go on do. He set up his own plumbing company, and employed himself to be his own plumbing Apprentice. Once he had his portfolio signed off, he would go on to complete his studies and become a fully qualified Plumber and Gas Engineer in the plumbing trade. But this was just the start of an eventful journey for Dave. Over the next few years, he would experience the horrors of Social Housing, the challenges of on-call work, angry and aggressive customers, and the importance of managing your finances. Yet somehow, with all this going on around him, Dave was able to create a piece of plumbing literature which would revolutionise the lives of so many Tradespeople from plumbers to electricians. "What piece of Literature?" I hear you ask. The aptly named... 'Breakdown Bible.' A Must for plumbers! If you want a copy for yourself: https://boilers-to-bathrooms.sumupstore.com/ Guest this week: Dave @boilerstobathrooms6267 Hosts: Mark @MJTiffPlumbing ⭐ Proudly Sponsored by CT1 | www.ct1.com | @ct1ltd ⭐ Supported by Tradify | https://tradifyhq.com/ | @TradifyHQ

In this week's episode of Trade Legends, @MJTiffPlumbing sits down with tiling expert Jack - someone who didn't initially see a future in the trades but, through perseverance and hard work, was able to setup his own successful tiling business, whilst making a name for himself across social media. From overcoming challenges on new build sites to creating bespoke tiled furniture, Jack will reveal what it takes to become a respected craftsmen and influencer. Learn about his experiences with social media, including the highs of viral content, but also the lows of dealing with fake accounts. Jack opens up about the pressures of content creation, maintaining a healthy work-life balance, and offers an important perspective on the realities of being a tradesperson in 2024. Guest this week: Jack the Tiler @jackthetileruk (Insta) Hosts: Mark @MJTiffPlumbing ⭐ Proudly Sponsored by CT1 | www.ct1.com | @ct1ltd ⭐ Supported by Tradify | https://tradifyhq.com/ | @TradifyHQ

From struggling with alcohol addiction to building a successful screeding business, Joe's story demonstrates how it's never too late to make a change. In this week's episode of Trade Legends, we discuss the challenges of mental health in the construction industry, the importance of a conversation, and how one pivotal moment at a music festival changed everything. Joe shares his experiences of working in both the food business and sales, before eventually finding his way into the screeding trade. We learn about the intricacies of liquid screed, underfloor heating installations, and the challenges that come with growing a small business in a short amount of time. Joe's candid discussion about work-life balance and the pressures of entrepreneurship offers valuable insights for all tradespeople. The conversation takes a dramatic turn when Joe opens up about his battle with alcoholism and mental health struggles, which in turn has given him the opportunity and drive to help others in similar situations. Joe's journey proves that with determination and the right support, it's possible to overcome any obstacle and build a successful career in the trades. Guest this week: Joe Baker @screedpapi (Insta) Hosts: Alex @alexinsley Mark @MJTiffPlumbing ⭐ Proudly Sponsored by CT1 | www.ct1.com | @ct1ltd ⭐ Supported by Tradify | https://tradifyhq.com/ | @TradifyHQ

Foxy, the face behind the popular decorating content on social media, shares his story from chef to decorator, and how he built his decorating business from scratch. He tells us all about his innovative inventions, including the patented Fox's Pro Shield, and the difficulties of balancing his thriving career with family life, and his ADHD-driven pursuits. Foxy also discusses his partnership with On The Tools and offers candid advice on brand deals and content creation, as well as opening up about overcoming personal challenges, including a 2 year £100,000 lawsuit that threatened his business. Also, don't miss Foxy's final thoughts and advice on taking the plunge into social media and seizing every opportunity that comes your way in the ever-evolving landscape of the construction industry. For anyone looking to expand their business horizons, build a brand, or simply enjoy some funny stories, then this is the episode for you. Guest this week: Foxy Devos  @FoxyTheDecorator  Hosts: Alex  @alexinsley  Mark  @MJTiffPlumbing  ⭐ Proudly Sponsored by CT1 | www.ct1.com | @ct1ltd ⭐ Supported by Tradify | https://tradifyhq.com/ | @TradifyHQ

In this week's episode of Trade Legends, we explore the world of carpentry with the one and only... Lewis Lai! Discover how he is able to juggle his flourishing business with a unique social media presence. From tackling cultural stereotypes to sharing insider tips on self-employment, Lewis offers his own take on the modern construction industry and what it takes to succeed within it. Lewis, a 27-year-old carpenter from Rugby, recounts his journey from apprenticeship to running his own successful business. With his distinctive personality, he's made a name for himself in both the physical and digital realms of carpentry. Learn how Lewis manages his ever-growing workload, engages with social media, and stays true to himself in a competitive field. He talks to us about the hurdles of self-employment, the value of continuous learning, and social media's impact on the trades as a whole. Lewis also candidly shares his relentless work schedule, as well as his method for handling online criticism. Guest this week: Lewis Lai @ll_carpentryandjoinery (Insta) Hosts: Mark  @MJTiffPlumbing  ⭐ Proudly Sponsored by CT1 | www.ct1.com | @ct1ltd ⭐ Supported by Tradify | https://tradifyhq.com/ | @TradifyHQ

Kelly Cartwright, founder of Core Recruiter, specialises in construction recruitment and is passionate about bringing both men and women into the industry. In this week's episode, we get a first-hand account of the shocking realities faced by many women in construction as Kelly shares her experiences. From combating stereotypes to receiving unsolicited explicit messages, Kelly's journey highlights the need for change within parts of the industry. This episode delves into the challenges of starting a business at 23, the importance of authenticity, and the unexpected viral success of Kelly's high-vis dress that took the world by storm. From myth-busting sessions in schools to advocating for better representation, Kelly is at the forefront of changing perceptions about construction careers. Her experiences shed light on the importance of mental health awareness in the industry and the need for more inclusive workplaces. Kelly's story is a testament to resilience and the potential for positive change in construction, inspiring both seasoned professionals and newcomers alike. Guest this week: Kelly Cartwright @corerecruiter (Insta) Hosts: Alex @bigaltradelegends (Insta) ⭐ Proudly Sponsored by CT1 | www.ct1.com | @ct1ltd ⭐ Supported by Tradify | https://tradifyhq.com/ | @TradifyHQ

Join us for Episode 75 as we dive into the world of carpentry, workwear, and business growth. We discuss the challenges of taking on apprentices, as well as the secrets of building a successful brand. Meet Ryan  @damson_carpentry  , a skilled carpenter who's navigated the ups and downs of self-employment and now manages a team of four. Learn about his experiences in the carpentry industry and how he's adapted to the changing landscape. Then, get to know Liam  @BrawnWorkwear  , an electrician who's made the bold move into the workwear industry with his brand, Brawn. Hear how he's bringing fashion and functionality together for tradespeople while building a supportive community. Our guests share their struggles, triumphs, and lessons learned in balancing work and family life. They discuss the importance of social media for modern tradespeople, the value of putting yourself out there, mental health in the trades, the impact of COVID-19 on business decisions, and the future of workwear. Guests this week: Ryan  @damson_carpentry  Liam  @BrawnWorkwear  Hosts: Alex @bigaltradelegends (Insta) ⭐ Proudly Sponsored by CT1 | www.ct1.com | @ct1ltd ⭐ Supported by Tradify | https://tradifyhq.com/ | @TradifyHQ

In this episode of Trade Legends, we attempt to tackle the complex issues surrounding apprenticeships, education, and the future of trades. From the disconnect between schools and employers to the changing landscape of the job market, the guys attempt to dissect the problems and propose innovative solutions. This week we welcome Lee @OnTheToolsOfficial , one of the original founders of the platform, and Ben and Jake from @ScolmoreGroup . These industry insiders bring their combined experience and unique perspectives to the table, offering insights into the current state of trade education and employment. Our guests discuss the importance of practical skills, the need for better communication between colleges and employers, and the potential for social media to inspire the next generation of tradespeople. Ben and Jake from the Scolmore Group give their own insights from the perspective of a leading electrical accessories manufacturer, shedding light on the challenges and opportunities in the electrical trade. You won't want to miss this important conversation about the future of the construction industry. Strap yourselves in! Guests this week: Lee @OnTheToolsOfficial Ben and Jake @ScolmoreGroup Hosts: Alex @bigaltradelegends Mark @MJTiffPlumbing ⭐ Proudly Sponsored by CT1 | www.ct1.com | @ct1ltd ⭐ Supported by Tradify | https://tradifyhq.com/ | @TradifyHQ

Join us for an inspiring conversation with Joe from Pure Projects, a young entrepreneur who's transforming the construction industry. Discover how Joe went from electrician to successful business owner, building a multi-million pound ecosystem of companies in just five years. Learn about his innovative strategies for growth, branding, and leveraging social media to stand out in a competitive market. Joe shares invaluable insights on scaling a construction business, including the importance of strategic partnerships, building the right team, and creating a strong online presence. He discusses his journey from running multiple small businesses to focusing on high-end residential projects and bespoke services. Joe's approach to business demonstrates how combining traditional trade skills with modern marketing techniques can lead to exponential growth. This episode is packed with practical advice for tradespeople looking to elevate their businesses. From the power of professional branding to the art of delegating, Joe offers a masterclass in entrepreneurship within the trades. He also touches on the challenges of rapid growth and the importance of maintaining quality while expanding. 00:00:00 Introducing 00:01:28 Joe's Story 00:20:44 The first 5 Years of the Business 00:30:07 Where do you see the Business going? 00:37:56 Attitudes towards Money 00:41:33 Starting the Podcast 00:47:38 Final Thoughts and Future Plans Guest this week: Joe @pureprojects_ (Insta) Hosts: Alex @bigaltradelegends (Insta) ⭐ Proudly Sponsored by CT1 | www.ct1.com | @ct1ltd ⭐ Supported by Tradify | https://tradifyhq.com/ | @TradifyHQ

In this week's episode of Trade Legends, we dive into the fascinating world of the highly talented stone mason Tom Whitehead @mainstonecarving , a master craftsman who's pushing the boundaries of this ancient trade. From creating intricate architectural features for luxury mansions to carving stunning memorials, Tom shares his journey and insights into this specialised craft. Discover the challenges of balancing traditional techniques with modern demands, and learn about the eye-watering costs of stone in today's market. Tom takes us through his career path, from art student to skilled stonemason, detailing his experiences working in Canada and the UK. He discusses the current state of stonemasonry education, the impact of technology on the trade, and the importance of preserving heritage buildings. Tom's passion for his craft shines through as he explains the difference between banker masonry and stone carving. Get an insider's view of the stonemasonry industry, including the high-stakes world of architectural stonework for luxury properties. Tom shares his thoughts on the future of the trade, the challenges of running a small business, and the satisfaction of creating lasting works of art in stone. He also touches on the physicality of the job and the importance of proper safety measures. Guest this week: Tom @mainstonecarving Hosts: Al @alexinsley ⭐ Proudly Sponsored by CT1 | www.ct1.com | @ct1ltd ⭐ Supported by Tradify | https://tradifyhq.com/ | @TradifyHQ

Discover the fascinating world of logging and firewood with  @georgiagoeslogging  In this eye-opening episode, we explore the challenges of a logging business in a male-dominated industry, the secrets of choosing the perfect firewood, and how social media revolutionised a 40-year-old family enterprise. Georgia shares her journey from biochemistry graduate to social media sensation in the forestry industry. Learn about the intricacies of moisture content regulations, the surprising questions customers ask about logs, and how Georgia's marketing background helped modernise her family's business. Her unique perspective offers valuable insights for anyone considering a career change or looking to innovate in traditional trades. From battling stereotypes to mastering heavy machinery, Georgia's story is one of determination and adaptability. She discusses the importance of work experience, the future of sustainable energy, and how social media has opened doors for collaborations with major industry players. Her success proves that there's more to logging than meets the eye. Guest this week: Georgia @georgiagoeslogging Hosts: Al @alexinsley ⭐ Proudly Sponsored by CT1 | www.ct1.com | @ct1ltd ⭐ Supported by Tradify | https://tradifyhq.com/ | @TradifyHQ

Dive into the thrilling world of competitive bricklaying with the founders of Super Trowel @bricklayerstvbsc the UK's most exciting construction competition! Discover how this groundbreaking event is revolutionising the industry, from its humble beginnings to securing major sponsors like @jewson and @WienerbergerOfficial . Learn about the intense 1-hour challenge where bricklayers compete to lay the most bricks with precision and speed. Meet Ash, Jack, and Joe - three passionate tradesmen who turned their vision into reality. From battling imposter syndrome to navigating corporate partnerships, these lads share their inspiring journey of creating an event that celebrates the skill and community of UK bricklayers. Hear about their eye-opening trip to Las Vegas that shaped Super Trowel's future and their plans for expansion. Get the inside scoop on what to expect at Super Trowel 2024, including custom-made tools, exclusive product launches, and an electrifying atmosphere complete with entrance music and T-shirt cannons. Learn how this event is bridging the gap between education and industry, offering opportunities for apprentices and seasoned pros alike. Don't miss this captivating episode that showcases the best of British trade innovation. Whether you're a bricklayer, construction enthusiast, or industry professional, Super Trowel is set to become the unmissable event of the year. Tune in to discover how you can be part of this exciting revolution in construction competitions! Get your tickets here : https://www.eventbrite.co.uk/e/super-trowel-2024-tickets-720866700707 Guests this week: Jack, Joe and Ash @bricklayerstvbsc Host: Mark @MJTiffPlumbing ⭐ Proudly Sponsored by CT1 | www.ct1.com | @ct1ltd ⭐ Supported by Tradify | https://tradifyhq.com/ | @TradifyHQ

The tool theft debate heats up as tradespeople face off against car boot sale defenders! In this episode of Trade Legends, we dive deep into the controversial issue of stolen tools being sold at car boots. Witness the passionate clash between those fighting to protect tradespeople's livelihoods and those defending the cherished British tradition of car boots. Shoaib,  @thegasexpert-yt  a dedicated advocate for the Trades United movement and anti-tool theft campaigner, has returned. Hear his compelling arguments for banning power tool sales at car boos and his firsthand experiences with the devastating impact of tool theft. On the other side, Walter  @AntiquesArena  , a seasoned car boot sale veteran, shares his concerns about the potential consequences of such a ban on the car boot sale community. The debate covers crucial topics like the scale of tool theft in London, the role of police and government in addressing the issue, and potential solutions such as tool marking and stricter regulations. Don't miss the heated exchanges on controversial points like the source of tools at car boot sales and the impact of online marketplaces on the problem. This unmissable episode of Trade Legends brings the tool theft crisis to the forefront, highlighting the urgent need for action while exploring the complex implications for various stakeholders. Whether you're a tradesperson, car boot enthusiast, or concerned citizen, this debate will leave you with plenty to ponder about the future of tool sales and theft prevention in the UK. Guests this week: Shoaib  @thegasexpert-yt  Walter  @AntiquesArena  Hosts: Nathan ⭐ Proudly Sponsored by CT1 | www.ct1.com | @ct1ltd ⭐ Supported by Tradify | https://tradifyhq.com/ | @TradifyHQ

Join us for Episode 68 of the Trade Legends Podcast, as we dive into the world of fibrous plastering, landscaping and even Death Threats! Mary @MaryPlasterMouldingsDirect a master of traditional fibrous plastering, and Mark @lawnstripesandhedges the man behind the successful "Lawns, Stripes and Hedges," share their inspiring journeys and reveal the secrets behind their crafts. From working on high-profile TV projects like The Gentlemen to dealing with online trolls, this episode is packed with captivating stories and valuable insights. Mary takes us through her journey in the world of fibrous plastering, a skill she learned from her father and brother. She discusses the intricacies of her work, from restoring cornices in Victorian houses to creating bespoke mouldings for prestigious clients like Harrods and the Ivy restaurants. Mary also shares her experiences as a woman in a male-dominated industry and her passion for passing on her knowledge to the next generation of fibrous plasterers. Mark's story is one of perseverance and dedication. From humble beginnings as a teenage troublemaker to becoming a successful landscaper and social media star, Mark's journey is nothing short of inspiring. He shares the challenges he faced along the way, including the loss of his best friend and the struggles of growing a business. Mark also discusses his experience with online trolls, death threats and the importance of staying true to oneself in the face of adversity. Throughout the episode, Mary and Mark share their favourite projects, their plans for the future, and their advice for aspiring tradespeople. From Mary's love for restoring historic buildings to Mark's passion for inspiring the next generation of landscapers, this episode is a must-listen for anyone interested in the trades. Guests this week: Mary @MaryPlasterMouldingsDirect Mark @lawnstripesandhedges Hosts: Alex @alexinsley Mark @MJTiffPlumbing ⭐ Proudly Sponsored by CT1 | www.ct1.com | @ct1ltd ⭐ Supported by Tradify | https://tradifyhq.com/ | @TradifyHQ

In this week's episode of Trade Legends, we dive deep into the world of tool theft and the groundbreaking protest that shook London. Join us as we uncover how one man's petition snowballed into a massive demonstration, bringing hundreds of tradespeople to Parliament Square and catching the attention of national media. Discover the shocking statistics behind tool theft and the innovative solutions being implemented to combat this epidemic. We welcome back Shoaib @thegasexpert-yt , the mastermind behind the tool theft protest, and he shares his journey from starting a petition to leading a movement that's changing the landscape of tool security. Hear firsthand accounts of the challenges faced, the unexpected support received, and the incredible impact this grassroots campaign has had on the industry. We delve into the aftermath of the protest, exploring the closure of car boot sales, increased police involvement, and the potential for legislative change. Learn about cutting-edge DNA marking technology and how it's being used to deter thieves and recover stolen tools. A truly inspiring tale of how tradespeople united to make their voices heard and the ongoing battle against tool theft. From the logistics of organising a protest to the future of tool security, this episode is packed with insights that every tradesperson needs to hear. Guests this week: Shoaib @thegasexpert-yt Pointy @pointyplumber Host: Mark @MJTiffPlumbing ⭐ Proudly Sponsored by CT1 | www.ct1.com | @ct1ltd ⭐ Supported by Tradify | https://tradifyhq.com/ | @TradifyHQ

Scott's @scott_diy story is one of determination, passion and DIY. From his early days as a tree surgeon to his successful career in marketing, Scott's diverse background has equipped him with a unique set of skills. When faced with the daunting task of renovating his own home, Scott took on the challenge head-on, teaching himself the trades through countless hours of research and hands-on experience. His dedication and hard work paid off, as he not only completed the renovation but also documented his journey on social media, captivating audiences worldwide. With a massive following of nearly 400,000 on Instagram and 175,000 on TikTok, Scott has become a prominent figure in the trade industry. His engaging content, which showcases his expertise in various trades such as bricklaying, plumbing, and electrical work, has earned him collaborations with top brands. In this episode, Scott shares his insights on navigating the world of influencer marketing, building genuine relationships with brands, and creating content that both informs and entertains. Throughout the episode, Scott shares his most memorable experiences, from his appearance on a Channel 4 renovation programme to his ambitious plans for the future. He offers valuable advice for aspiring influencers and those looking to pursue their passions, emphasising the importance of staying true to oneself and tackling challenges head-on. Whether you're a seasoned tradesperson, a DIY enthusiast, or simply looking for inspiration, this episode is packed with actionable tips and heartfelt stories that will leave you motivated and ready to take on your own projects. Guest this week: Scott @scott_diy Hosts: Alex @bigaltradelegends (Insta) ⭐ Proudly Sponsored by CT1 | www.ct1.com | @ct1ltd ⭐ Supported by Tradify | https://tradifyhq.com/ | @TradifyHQ

In this episode of Trade Legends, we dive into the world of wealth management with special guest Matt from H-J Wealth Planning. Discover insider secrets on maximising your income, building a secure financial future, and avoiding common money mistakes. From pensions and property investments to tax efficiency tips, this episode is packed with valuable insights for everyone. Matt shares his inspiring journey from leaving school at 15 to becoming a successful wealth manager. With a huge amount of experience in the financial industry, Matt brings his knowledge of smart money management which anyone can benefit from. Throughout the episode, Matt highlights the importance of financial education and building good habits from a young age. He discusses the power of pensions, revealing how investing just £50 a month into a child's pension from birth could lead to them becoming a self-made millionaire. Matt also delves into property investment strategies, tax relief opportunities, and the benefits of using a limited company structure for your business. Don't miss this opportunity to learn from one of the best in the business. Matt shares his top tips for reducing your tax bill, protecting your assets, and securing a comfortable retirement. Whether you're an apprentice, just starting out or a seasoned investor looking to take your finances to the next level, this episode of Trade Legends is a must-listen. Guest this week: Matt @hjwealthplanning (Insta) Host: Alex Insley @bigaltradelegends (Insta) ⭐ Proudly Sponsored by CT1 | www.ct1.com | @ct1ltd ⭐ Supported by Tradify | https://tradifyhq.com/ | @TradifyHQ

In this week's episode of Trade Legends, content creating hacks & celebrity clients. We dive into the fascinating worlds of bespoke shoes and edgy marketing. Join us as we uncover secretly recorded messages, trade secrets, explore the power of networking, and discover the passion that drives true craftsmanship. From the gritty, Blade Runner-esque aesthetics of Dissident Marketing to the intricate art of creating custom, handmade shoes, this episode is a must-watch for anyone seeking inspiration and insight. Our first guest Dan, the founder of 'Dissident Creative Agency', shares his creative journey. With a focus on creating content that stands out in the construction industry, he reveals the importance of building a strong network, how to know if someone secretly records you, and the value of taking calculated risks. Learn how his company's unique approach has attracted clients like Fischer, and how they're revolutionising the way construction brands market themselves. Next, we sit down with James and Deborah, the dynamic duo behind the independent bespoke shoemaking company 'Carreducker'. With a combined experience of over 20 years, they share their passion for preserving traditional craftsmanship while embracing innovation. From James' apprenticeship at John Lobb to Deborah's Queen Elizabeth Scholarship, discover the dedication and skill that goes into creating a pair of bespoke shoes. Plus, get an inside look at their workshop in the heart of London and learn how they've adapted to the challenges of Brexit and the COVID-19 pandemic. Throughout the episode, we explore the common threads that tie these seemingly disparate trades together: a commitment to quality, a willingness to take risks, and a deep love for their craft. Whether you're a seasoned tradesperson or simply curious about the world of artisanal craftsmanship, this episode is packed with valuable insights and engaging stories. So sit back, relax, and prepare to be inspired by the passion and expertise of our incredible guests. Guests this week: Dan @dissidentcreativeagency4416 James and Deborah @Carreducker Host: Mark Tiff @MJTiffPlumbing ⭐ Proudly Sponsored by CT1 | www.ct1.com | @ct1ltd ⭐ Supported by Tradify | https://tradifyhq.com/ | @TradifyHQ

Join us for an exclusive interview with Nicola Walsh, the dynamic Sales and Marketing Director of CT1, the UK's leading sealant and adhesive brand. In this episode of Trade Legends, Nicola takes us on a captivating journey through her career, the growth of CT1, and the challenges of being a female leader in the construction industry. Discover the secrets behind CT1's success and learn valuable lessons on building a thriving family business. Nicola Walsh's story is one of determination, innovation, and resilience. From her early days working in various marketing roles to her decision to join the family business, Nicola's experiences have shaped her into the influential leader she is today. As CT1's Sales and Marketing Director, she has played a pivotal role in establishing the brand as the go-to choice for professional tradespeople and DIY enthusiasts alike. Throughout the episode, Nicola shares insights on CT1's unique company culture, the importance of building strong partnerships, and the brand's commitment to developing high-quality, innovative products. She also discusses the challenges of being a woman in the construction industry and the positive changes she's witnessed over the years. Nicola's passion for empowering female tradespeople shines through as she highlights the importance of diversity and inclusion in the sector. Host: Mark Tiff @MJTiffPlumbing ⭐ Proudly Sponsored by CT1 | www.ct1.com | @ct1ltd ⭐ Supported by Tradify | https://tradifyhq.com/ | @TradifyHQ

In this episode of Trade Legends, we celebrate International Women's Day by bringing together two incredible guests, Pixie from Pixie Heating and Michelle from She Who Dares, Wins. These inspiring women share their journeys into the trades, discussing the challenges they've faced, the freedom they've found, and the importance of encouraging the next generation of tradeswomen. From working alongside ex-cons to battling toxic work environments, this episode is a must-listen for anyone interested in the construction and plumbing industry, and women's experiences in the trades. Michelle's story is one of resilience and determination. She shares her unconventional path into the world of engineering, from studying geography to working on landfill sites. Despite facing discrimination and challenging work environments, Michelle's passion for her work and her dedication to inspiring other women in the industry shine through. Her honesty about the struggles she's faced and the importance of male allies in creating change is both refreshing and empowering. Pixie's journey is equally inspiring. She shares her experience of becoming a plumber at 30, after years of struggling to find her place in the workforce. From burning her school uniform to riding a micro scooter to work, Pixie's story is one of perseverance and hard work. She discusses the financial freedom and job satisfaction she's found in her trade, and the importance of sharing her story to inspire other women to pursue careers in the trades. Throughout the episode, both Pixie and Michelle emphasise the importance of encouraging girls and young women to consider careers in the trades. They discuss the need for more exposure to trade careers in schools, and the role that social media can play in normalising the presence of women in the construction industry. With their honest and engaging stories, Pixie and Michelle are paving the way for a more inclusive and diverse future in the trades. Guest this week: Michelle @SheWhoDaresWins Pixie @pixie_heating (Instagram) Host: Alex Insley @bigaltradelegends (Instagram) ⭐ Proudly Sponsored by CT1 | www.ct1.com | @ct1ltd ⭐ Supported by Tradify | https://tradifyhq.com/ | @TradifyHQ

Join us as we sit down with Kev, a seasoned carpenter who shares his incredible journey from apprentice to globe-trotting professional. From surviving AK-47 attacks in Lagos to encountering dead bodies on the road, Kev's experiences will leave you on the edge of your seat. He also shares valuable insights on the importance of vocational education and the limitless opportunities available in the trades. Kev's career has taken him from boatbuilding to lecturing aspiring tradespeople. His passion for the trades is evident as he recounts his experiences working on bombproof windows in embassies across the world. Kev's story is a testament to the diverse range of opportunities available to those who pursue a career in the trades. Throughout the episode, Kev emphasises the significance of apprenticeships and practical skills. He discusses the need for a more balanced approach to education, one that values vocational training as much as academic pursuits. Kev's own journey demonstrates how a career in the trades can open doors to exciting and fulfilling experiences. From his harrowing tales of working in dangerous locations to his insights on the future of the trades, Kev's story is one that will inspire and captivate listeners. Guest this week: Kevin Page @pentagon.carpentry.and.joinery Host: Alex Insley @bigaltradelegends ⭐ Proudly Sponsored by CT1 | www.ct1.com | @ct1ltd ⭐ Supported by Tradify | https://tradifyhq.com/ | @TradifyHQ

Darcie, a.k.a. Rattle Kings, is BACK! The original trade girl who shocked the world with her controversial move from bricklaying to OnlyFans. Darcie bares all about her rollercoaster journey, from the backlash she faced to the staggering capital she's now earning. Buckle up for a wild ride as we dive deep into Darcie's story and explore the realities of being a woman in the trades. Darcie, a skilled bricklayer, takes us through her experiences working in the UK and Australia, where she faced the challenges of being a woman in a male-dominated industry. She shares her struggles with finding consistent work and the financial pressures that led her to consider OnlyFans as a solution to her mounting debts. With unflinching honesty, Darcie opens up about the moment she decided to take the plunge into OnlyFans and the immediate impact it had on her life. From paying off her debts in just two days to dealing with the onslaught of online abuse, Darcie's story is one of resilience and determination in the face of adversity. In this no-holds-barred interview, Darcie reveals the jaw-dropping figures she's earning on OnlyFans and how her life has changed since making the switch. She shares her thoughts on the future of the platform, the importance of staying true to yourself, and her plans for the future. Don't miss this unforgettable episode packed with shocking revelations, invaluable insights, and a whole lot of heart. Guest this week: Darcie Richard aka Rattle Kings @rattlekings Host: Mark Tiff @MJTiffPlumbing ⭐ Proudly Sponsored by CT1 | www.ct1.com | @ct1ltd ⭐ Supported by Tradify | https://tradifyhq.com/ | @TradifyHQ

Discover the fascinating world of farriery and the incredible journey of the skilled tradesman, and TikTok superstar, Sam Dracott. Join us as we delve into the art and science of horseshoeing, explore the challenges and rewards of the trade, and uncover the secrets behind one farrier's viral success on TikTok. Sam, a master farrier with years of experience, shares his unique perspective on the equine industry and the importance of balancing tradition and innovation in his craft. From his humble beginnings as an apprentice to his rise as a social media star, he offers valuable insights into the world of farriery and the power of digital platforms to educate and inspire. Throughout the episode, we discuss the intricacies of horseshoeing, the importance of animal welfare, and the role of farriers in maintaining the health and performance of horses. Our guest also shares his experiences working with various breeds and disciplines, from racing to polo, and the challenges of serving a diverse clientele. Don't miss this engaging and informative conversation that covers everything from the history of horseshoes to the future of the farriery trade. Whether you're a horse enthusiast, an aspiring farrier, or simply curious about this fascinating profession. Guests this week: Sam Dracott @samdracott_farrier Host: Mark Tiff @MJTiffPlumbing ⭐ Proudly Sponsored by CT1 | www.ct1.com | @ct1ltd ⭐ Supported by Tradify | https://tradifyhq.com/ | @TradifyHQ

We dive into the world of construction and landscaping with two incredible guests: Tom from Garden Scape and Ollie from Stabila Levels. Discover the secrets behind Stabila's 135-year history of precision measuring tools and learn valuable life lessons from a chef turned landscaper. Get ready for a jam-packed episode filled with insights, humour, and inspiration! Tom, the founder of Garden Scape, shares his remarkable journey from the chaotic world of professional kitchens to the serene beauty of landscape design. With a passion for creativity and a knack for problem-solving, Tom has built a thriving business that transforms outdoor spaces into stunning oases. Learn how he navigated the challenges of changing careers, honed his skills, and embraced the power of social media to showcase his work and connect with clients. Ollie, a representative from Stabila Levels, takes us on a fascinating journey through the company's 135-year history of innovation and precision in measuring tools. Discover the intricate process behind the creation of Stabila's renowned spirit levels, from the hand-assembly of vials to the cutting-edge technology that ensures unparalleled accuracy. Ollie shares insider tips on how to choose the right measuring tools for your projects and emphasises the importance of investing in quality equipment to avoid costly mistakes. Throughout the episode, Tom and Ollie engage in lively discussions, sharing anecdotes, and offering valuable advice for aspiring tradespeople. From the importance of transparency and owning your mistakes to the power of perseverance and skill development, this episode is a treasure trove of wisdom for anyone looking to succeed in the construction industry. Guests this week: Ollie | Stabila  @STABILAOfficial  Tom | Garden Scape Wiltshire Host: Mark Tiff | @MJTiffPlumbing Gavin | Pablo Plumbcobar ⭐ Proudly Sponsored by CT1 | www.ct1.com | @ct1ltd ⭐ Supported by Tradify | https://tradifyhq.com/ | @TradifyHQ

From rubbing shoulders with A-list celebrities in Ibiza to crafting stunning floors for Lamborghini's 60th anniversary, these boys have seen it all. Buckle up for a wild ride as they share the secrets behind their meteoric rise in the industry and the sleepless nights that come with the pursuit of resin flooring perfection. Meet Lou, Harry, Ollie, and Stu - the dream team behind Gafflow Resin Finishes. With Lou's multi-trade background, Harry's artistic flair, Ollie's electrical expertise, and Stu's meticulous prep work, this foursome has taken the resin flooring world by storm. Discover how their unwavering passion and relentless work ethic have propelled them to the top of their game, earning them high-profile clients and international recognition. From humble beginnings in South London to globetrotting adventures in Miami, Barcelona, and beyond, the Gafflow crew has embraced every challenge and opportunity that has come their way. Learn how they've navigated the ups and downs of running a successful business while maintaining their tight-knit family dynamic and never losing sight of their ultimate goal - to revolutionise the flooring industry one stunning design at a time. In this episode, the boys hold nothing back as they dish on the wild parties, celebrity encounters, and jaw-dropping projects that have defined their journey. But it's not all glitz and glamour - they also delve into the sacrifices they've made along the way, from missing out on precious family time to pushing their bodies to the limit with grueling work schedules. Will their relentless pursuit of success come at too high a cost? Tune in to find out and discover why Gafflow Resin Finishes is the name on everyone's lips in the world of high-end flooring design! Guests this week: Lou, Harry, Ollie and Stu | Gafflow Resin Finishes @Gafflowresinfinishes Host: Mark Tiff @MJTiffPlumbing ⭐ Proudly Sponsored by CT1 | www.ct1.com | @ct1ltd ⭐ Supported by Tradify | https://tradifyhq.com/ | @TradifyHQ

Join MJ Tiff, Alex and the Trade Legends crew as they welcome two special guests - Rod from The Right Flooring Company and Chris from Vanguard, a leading British van accessories manufacturer. In this insightful episode, they dive into the world of flooring, roof racks, van security, and the challenges faced by independent tradesmen. Rod shares his entrepreneurial journey, from his college days dabbling in micro-businesses to starting his own flooring company during the COVID-19 pandemic. Discover how he navigated the ups and downs, managed cash flow, and scaled his team to handle the ever-increasing demand for residential and social housing projects. Meanwhile, Chris offers an inside look at Vanguard, a true British manufacturing powerhouse. Learn about their state-of-the-art facilities in Exeter, their extensive range of roof bars, interior van racking, and cutting-edge security solutions designed to combat the rising van theft crisis plaguing the trade industry. You won't want to miss the frank discussion on the rampant issue of van theft and break-ins plaguing tradespeople across the nation. Rod and Chris pull no punches as they recount shocking stories of vans being stripped bare and the emotional toll it takes when criminals target a tradesman's livelihood. Chris even raises the controversial idea of bringing on an "ex van theft" to provide insights into their brazen tactics and mindset - a jaw-dropping proposal that could ruffle some feathers but might just offer the kind of counterintuitive perspective needed to stay one step ahead of the criminals. Brace yourself for this unfiltered, no-holds-barred conversation tackling one of the trade industry's biggest threats head-on. This episode is a must-watch for plumbers, electricians, flooring specialists, and any tradesperson seeking valuable insights into running a successful business, managing a team, and staying ahead of the curve with innovative products. Don't miss the opportunity to gain insider knowledge from industry experts and fellow tradesmen who have faced and overcome similar challenges. Guests this week: Chris | Vanguard  @VanGuardAccessories  Rod | The Right Flooring Company Hosts: Alex Mark Tiff  @MJTiffPlumbing  ⭐ Proudly Sponsored by CT1 | www.ct1.com |  @ct1ltd  ⭐ Supported by Tradify | https://tradifyhq.com/ |  @TradifyHQ 

Hollie initially pursued a career in marine biology but found herself disenchanted with the industry. After exploring various job opportunities, she was diagnosed with ADHD. Serendipitously, she encountered an opportunity to train as an oil boiler engineer. Hollie successfully qualified and began working for a company in the field. In 2017, fueled by her passion and desire for autonomy, she took the bold step of establishing her own business. Becca faced academic challenges and was expelled from school for inadvertently causing a fire. Undeterred, she enrolled in college to learn about plumbing. Despite personal setbacks delaying her apprenticeship, Becca eventually started the program. Overcoming the gender biases on construction sites, she gained experience in social housing for several years. Transitioning to the private commercial sector, Becca found her niche, thoroughly enjoying her work with a company in the field. Guests this week: Hollie and Becca

In 2023, James achieved success by winning the 'On the Tools' Decorating Award. His journey to this accomplishment started after leaving school when he gained work experience as a plumber, an endeavour that proved less than satisfying, prompting him to explore other avenues. Opting for painting and decorating, James secured an apprenticeship with a reputable company, where he honed his skills and gained valuable experience. His commitment and passion eventually led him to establish his own prosperous painting and decorating company, showcasing his resilience and dedication to building a successful career in a field he found fulfilling. Guest this week: James

Dee, a criminology graduate, initially worked with domestic violence victims before venturing into a different field in America, where she enjoyed her time working with Hooters. After having two children, she returned to the UK and reluctantly took up an office job that she found unfulfilling. Dissatisfied with her career path, Dee decided to learn the trades of tiling and plastering. Discovering a passion for plastering, she successfully integrated her work with her family life, securing jobs with local companies. Eventually, Dee took the leap to entrepreneurship, establishing her own plastering business. Stan's journey began with academic challenges, but he found his calling through a plumbing apprenticeship with his father. After a stint with Virgin Media, Stan returned to plumbing before taking on a role in a hospital's plastic surgery ward. His desire to be his own boss led him back to plumbing, where he successfully established his own plumbing company. The onset of the COVID-19 pandemic presented challenges, but Stan adapted by becoming a reactive plumber and found increased demand for his services. Prioritising family, Stan learned how to balance work and family life, enabling him to spend more time with his children while continuing to thrive in his entrepreneurial venture. Guests this week: Dee and Stan

Nathan's journey took unexpected turns as he initially aimed to join the RAF but was hindered by the need for glasses. Undeterred, he pursued electrical engineering in college before finding himself in an apprenticeship as a bricklayer, where he faced exploitation as cheap labor. Despite the challenges, he persevered and eventually qualified. Nathan then stumbled upon  @CraigToddBrickwork  For the past six months, he has been under Craig's guidance, rekindling his passion for bricklaying. Meanwhile, Craig's story started with a childhood dream of becoming a DJ at the age of 10. His interests shifted towards computers after leaving school, but a newfound fascination with bricklaying led him to college and hands-on experience with local artisans. Craig wasted no time and set up his own bricklaying business, forging a path with his passion for bricklaying. Guests this week: Nathan and Craig

Roger Bisby @SkillBuilder left school without qualifications but pursued a plumbing apprenticeship. Taking a break during the "summer of love" with little money, he resumed plumbing upon his return. Roger transitioned into writing for DIY magazines and later ventured into radio and TV, including LBC radio and the BBC. Unhappy with how tradesmen were portrayed on rogue trader shows, he left and started a successful YouTube channel with a substantial following. Dan, on the other hand, has been a carpenter for nearly three decades, starting his carpentry apprenticeship after working with his dad on weekends. Over the years, he worked for various companies and met Roger while advertising his carpenter's square in a magazine. Collaborating, they explored effective marketing strategies for the square. Dan's interest in designing innovative tools for carpenters emerged from these discussions, leading to their joint ventures in the field. Guests this week: Roger and Dan

Liam's upbringing was steeped in hard work and perseverance. His father's occupation as a black cab driver and his mother's role as a personal assistant instilled in him the values of diligence and resourcefulness. Starting as an apprentice for an electrician, Liam swiftly realised the absence of comfortable workwear in his field. This realisation became the catalyst for his entrepreneurial journey. Recognising the need for better attire that could withstand the demands of labor while prioritising comfort, he took the leap to create Comodo Workwear. Drawing from his experiences and fuelled by his determination, Liam ventured into the world of apparel, carving a niche by catering to the practical needs of workers like himself who craved functionality without sacrificing comfort. His dedication to providing quality workwear stemmed from a genuine understanding of the challenges faced by labourers, and it transformed him into an innovator in the industry, reshaping the way people approached their work attire. Georgina's journey unfolded against the backdrop of a family deeply rooted in a legacy of hard work. Excelling in academics, she pursued a drama degree after her schooling, drawn to the art of storytelling and teaching. However, her family's association with Rolls Royce opened unexpected doors. Joining the events management department, she discovered a different avenue—a world where precision and grandeur intersected. Transitioning to JCB introduced her to the dynamic realm of construction. Imbued with curiosity, Georgina delved into understanding the machinery, particularly diggers. Her passion led her to operate these machines herself, mastering their intricacies and functionalities. This unexpected turn in her career path transformed her into a beacon of knowledge, not as a traditional teacher but as an instructor in an unconventional classroom—a construction site. Georgina found fulfilment in sharing her expertise, educating others about the machines she had come to admire, and bridging the gap between theory and practical knowledge in an industry she hadn't initially envisioned herself being a part of. Guests this week: Liam and Georgina

Fred's journey from scaffolding to founding the Walther Strong Company encapsulates a remarkable evolution driven by introspection. After a devastating incident, he redirected his path, embracing timber lock screws alongside his brother. Relocating to Norfolk, his expertise expanded into sealant work for the food industry, eventually extending to broader trades. The inception of Walther Strong in 2016 marked a pivotal moment, leading Fred towards entrepreneurship and, more recently, investing. Meanwhile, Mark's transition from law enforcement to carpentry underscores a different yet equally compelling narrative. His tenure as a police officer, laden with stress and poignant experiences, steered him towards a fulfilling career in carpentry. Meeting his employer, Dave, marked the start of a dedicated journey as a full-time tradesman, a role that speaks to his resilience and pursuit of contentment. Special Guest Presenter: Dave (Elwood Enterprises) Guests this week: Fred and Mark

Ryan's journey spans continents and industries, a tale woven with diverse experiences. From growing up near the 'Neighbours' set in Australia to a brief stint in the airforce and cricket in the UK, his path meandered through trade-related work back home and a return to the UK where love awaited. Marriage beckoned, and with it, the venture into business—navigating the complexities of marketing trade-related workwear and boots for renowned brands like Blue Steel in the UK. Yet, the delicate act of balancing entrepreneurship with family life posed its challenges. Meanwhile, Luke's story took a different turn, evolving from a promising academic background into the realm of gas engineering. Amidst success, the emergence of OCD clouded his life, spiralling into a daunting mental health ordeal that nearly cost him his livelihood and home. Courageously, he sought help, navigating a path through medication and therapy. Social media became his canvas, showcasing his work and life, ultimately earning him recognition as a nominee for Plumber of the Year. Two lives, distinct in their narratives, interwoven by resilience and a pursuit of purpose. Guests this week: Ryan and Luke

Shoaib's journey into becoming a gas engineer was sparked by a fortuitous encounter with a skilled technician fixing a leak in his home. Inspired, he dove into an intense course, later shadowing the same expert to learn the craft, driven not by payment but a thirst for knowledge. His pride in precision and skill led him to share insights on gas safety with ITV after an unfortunate gas explosion in Birmingham. Aaron, a versatile soul, found solace in tattoo artistry just before the onset of COVID, stalling his dream of an independent studio. His diverse career, from carpentry with his father, accounting, and to navigating the competitive tattoo industry, reflects his persistent pursuit of fulfilling passions amidst life's challenges. Guests this week: Shoaib and Aaron

Tyson  @fairwayplumbing  and Pete  @plumbertales8772  , both plumbers by trade, come from diverse backgrounds but share a common passion for encouraging others to pursue their dreams. Tyson's journey into plumbing began as an unexpected twist, transitioning from carpentry into the world of pipes and fixtures through his brother-in-law's guidance. Raised in a council estate, he observed racial challenges within the construction industry but chose to rise above them, urging others not to be deterred by obstacles and to push through with determination. Pete, on the other hand, dabbled in various jobs during his youth, but his decision to become a plumber was motivated by a desire to follow his heart. Raised by visually impaired parents, he ventured into social media and discovered his talent for comedy and funny content creation. He explored stand-up comedy and even took acting classes, all while encouraging others to chase their passions fearlessly. Guests this week: Pete and Tyson

Pablo and Robbie, two close friends from Wales, share a unique journey of determination and resilience. Pablo's path took him through various sales jobs before he decided to embark on a career as a plumber. He dedicated himself to an apprenticeship, putting himself through college and honing his plumbing skills. Along the way, he faced personal challenges, including hearing loss, but his unwavering commitment allowed him to bounce back and return to his passion for plumbing. On the other hand, Robbie's journey began with struggles in school, but he managed to secure decent GCSE results. Initially aspiring to be a gamekeeper, he wisely chose to first acquire a trade. Robbie secured an apprenticeship, gained invaluable experience on the job, and eventually ventured out to work for himself. Both friends' stories highlight the power of perseverance and the pursuit of one's dreams in the face of adversity. Guest host this week @MJTiffPlumbing Guests this week: Gavin and Robbie

In the second part of this gripping podcast episode, we dive deeper into the explosive showdown that unfolded between homeimprovements during their live broadcast. Tensions had been simmering for years, but that fateful on-air clash might have pushed their relationship to the brink of no return. Can they find a path to reconciliation, or does this mark the end of an era for these once-inseparable siblings. Guest host this week @MJTiffPlumbing Guests this week: The Home Improvements Channel UK

Phil, Brad, and Jack, three brothers with backgrounds in the trades, found an unexpected path to success through social media  @homeimprovements  Despite facing challenges in formal education, they pooled their skills to excel in fitting floors and carpets. Their journey took a turn when they stumbled upon the  @NBundyElectrical  YouTube channel and saw the possibilities it offered. Inspired by his success, they decided to create their own content, sharing their trade expertise and tips. With dedication and hard work, their social media presence grew exponentially, eventually leading them to quit their traditional jobs and focus solely on their flourishing online careers, proving that passion and perseverance can pave the way to unexpected triumphs. Guest host this week  @MJTiffPlumbing  Guests this week: The Home Improvements Channel UK

Thanks to our Sponsors: Viome. Take the guesswork out of which foods and supplements your body needs. https://www.viome.com/    Use promo code UFA or UFA110 for a discount up to 110 dollars off any order. And our guest https://www.cregaatine.com/   2X Creatine Monohydrate Sergej M. Ostojic MD, PhD, received his graduate medical degree (Doctor of Medicine) from the University of Belgrade School of Medicine in September 1996. He then pursued his postgraduate training in biomedical science, and obtained MSc in Medical Sciences (2001) and PhD in Medical Sciences (2003) at the University of Belgrade, with CME and postdoc education includes training in mitochondrial medicine (Mayo Clinic College of Medicine and Science), and nutrition, obesity and metabolism (Harvard Medical School and Harvard University T.H. Chan School of Public Health). He is currently working as Professor of Nutrition at the University of Agder, Professor of Biomedical Sciences at the University of Novi Sad, and Head of Applied Bioenergetics Lab (www.appliedbioenergetics.org), and Professor of Health Sciences at the University of Pécs. He has been appointed as Visiting Professor at the University of Zagreb (2009) and the University of Central Florida (2014-2015), and Erasmus Teaching Fellow at the University of Rome (2017). His current research follows two main themes: studying mitochondrial viability and targeted nutritional interventions to tackle impaired bioenergetics in health and disease, and analyzing population health metrics in chronic cardiometabolic diseases. To date, he has authored and co-authored over 300 peer-reviewed articles in multidisciplinary journals, including those with high impact factors such as The Lancet, Nature, The BMJ, Trends in Food Science and Technology, Trends in Endocrinology and Metabolism, Advances in Nutrition, Mayo Clinic Proceedings, Clinical Nutrition, Pharmacological Research, Nutrients, European Journal of Nutrition, Nutritional Neuroscience; 120+ invited lectures and conference abstracts; 13 book chapters, and 4 textbooks. He earned over 15,500 citations on his account so far, with H-index 35 (Scopus). He is a member of the American College of Physicians, the American Society for Nutrition, the International Society for Cerebral Blood Flow and Metabolism, Mitochondrial Medicine Society, and the Nutrition Society. Dr. Ostojic is also a member of international research networks in population health, including European Childhood Obesity Surveillance Initiative (World Health Organization), NCD Risk Factor Collaboration (Imperial College London), and Global Burden of Disease (University of Washington). He is Associate Editor of the scientific journals Clinical Nutrition ESPEN, Frontiers in Physiology and Research in Sports Medicine, Assistant Editor for Current Topics in Nutraceutical Research, Review Editor for Frontiers in Nutrition and Frontiers in Pharmacology, and Editorial Board Member for Nutrition, Nutritional Neuroscience, Food Science and Nutrition, and Journal of Functional Foods. He has been the recipient of internationally competitive research grants including the the European Commission, WADA Scientific Research Grant, and NSCA International Award, and many industrial endowments. He holds 8 patents and patent applications in the US, UK, EU, and Japan. 3:00 Dr. background 3:20 how creatine improves neurodegenerative disorders, metabolic disorders, chronic fatigue syndrome 3:50 how to give a boost to creatine story outside of the athlete field 4:09 in the past we've known how important creatine is to muscle growth but now we are discovering how critical it is to overall health 4:56 creatine very effective at supporting normal brain activity 5:30 next big thing in creatine research is how to deliver more of it to the brain 5:50 increasing creatine in the gray matter of the brain by 3.9 X! 5:57 increasing the creatine in the white matter of the brain by 1.9 X! 6:19 GAA mixed with creatine 7:25 effective for cardiovascular conditions 7:45 GAA can be delivered not just through the CT1 receptors like creatine but also through many different receptors as well 9:18 GAA has four ways to enter the cell 17:26 nootropic effects of combining GAA and creatine monohydrate 18:33 Cregaatine's effect on the big four killers: heart disease, dementia, cancer, diabetes 18:50 diabetes 19:20 dementia 20:30 cardiovascular conditions 21:10 cancer 21:50 the weird intersection of trying to starve cancer from insulin, glucose, glycogen and the anabolic state and yet needing to build muscle to regain health and vitality 25:06 The dementias 30:30 GAA combined with creatine monohydrate might be even more effective for women

Guest host Dr. Neeraj Agarwal and Dr. Christian Kollmannsberger discuss practice-changing abstracts that were presented at the 2023 ASCO Genitourinary Cancers Symposium, including results from the TALAPRO-2, PROpel, TRITON3, ARASENS, KEYNOTE-057, CheckMate 274, and CheckMate 9ER studies. TRANSCRIPT Dr. Neeraj Agarwal: Hello and welcome to the ASCO Daily News Podcast. I'm Dr. Neeraj Agarwal, the director of the Genitourinary Oncology Program, and professor of Medicine at the Huntsman Cancer Institute at the University of Utah, and editor-in-chief of the ASCO Daily News.  Today, we will be discussing practice-changing abstracts and other key advances in GU Oncology featured at the 2023 ASCO Genitourinary Cancers Symposium. Joining me for this discussion is Dr. Christian Kollmannsberger, the chair of this year's ASCO GU. Dr. Kollmannsberger is a GU medical oncologist at the BC Cancer Vancouver Cancer Center and a clinical professor at the University of British Columbia.  Our full disclosures are available in the transcript of this episode, and the disclosures of all guests on the podcast can be found on our transcripts at asco.org/DNpod.  Christian, thank you for joining us on the podcast today.  Dr. Christian Kollmannsberger: Thank you very much, Neeraj. It's a real pleasure to be here and have this discussion. Dr. Neeraj Agarwal: Thank you. So, Christian, the GU meeting featured remarkable progress in various GU malignancies. Could you please share some of the prominent topics that made the headlines this year and give us an overall feel of ASCO GU this year? Dr. Christian Kollmannsberger: Absolutely. I think it was a great meeting with over 5,800 attendees from more than 70 countries. And most of the attendees were in person, so it was a great event. ASCO GU is truly the premier global event to feature the very best of GU cancer research and treatment. The theme of this year's meeting was "Today's Science, Tomorrow's Treatment," and that was reflected in the novel scientific and clinical findings that were presented and will potentially lead to changes in our daily clinical practice. It also reminds us how quickly the development today is and how quickly novel scientific progress is immediately translated into clinical practice, particularly oncology.   I was very impressed by the meeting's emphasis on diversity, interactivity, networking, multidisciplinary collaboration, and evidence-based care. We introduced several new features such as a “Meet the Professor session, a women's networking event, etc. And the first day really kicked off with a very rich focus on prostate cancer and much attention given to PARP inhibitors in our first session. As an example, LBA 17 was the first late-breaking abstract presented. And congratulations to you, Neeraj, on delivering this exciting data on the TALAPRO-2 trial, which were eagerly awaited. Let's start with that. Can you tell us about this trial? Dr. Neeraj Agarwal: Yes, of course. So the TALAPRO-2 trial was a phase 3 randomized trial where patients in newly diagnosed metastatic CRPC settings were randomized to standard of care enzalutamide plus placebo versus enzalutamide plus talazoparib PARP inhibitor. And as we know, Christian, the rationale has been that dual inhibition of PARP and AR may enhance the efficacy of each. And there's a laboratory preclinical rationale and based on which other studies have been done in the past. So, without getting into too much detail into the rationale for the trial, I'll come right to the results of the trial. So, this was the first-line mCRPC setting where rPFS was the primary endpoint as assessed by the independent radiology assessment. And in this trial, patients were recruited regardless of the homologous recombination repair gene alterations. So, patients were recruited and they were prospectively tested for whether they had these HRR gene alterations or not, but all comer population was included in this trial. And after a median follow-up of approximately 23 months, the trial read out, and we found that trial made the primary endpoint was improved radiographic progression-free survival with the rPFS being about 22 months in the enzalutamide arm and not reached in the combination arm with a 37% reduction in risk of progression or death.  If you look at the subgroup analysis of patients who were HRR+, there was a 54% reduction risk of progression or death. If you look at patients who were stratified in HRR- or unknown group, there was a 30% reduction risk of progression or death. If you specifically look at an exploratory analysis we did to look for patients who were HRR- by prospective tumor tissue testing; there was a 34% reduction in risk of death with a hazard ratio of 0.66 favoring the combination arm. So overall, the rPFS primary endpoint was met in all groups. We also see significant delay in PSA progression in the combination arm by more than nine months. We also see delays in the time to cytotoxic chemotherapy. We saw delay in progression or death on subsequent neoplastic therapy after the protocol treatment. We saw delays in deterioration of quality of life and global health status. All these were significant and happened on the talazoparib plus enzalutamide arm.  So overall, if you look at the totality of the data, these all favored the combination of talazoparib plus enzalutamide compared to enzalutamide alone. I want to highlight that overall survival is immature at 31% maturity with a hazard issue of 0.89, currently favoring enzalutamide plus talazoparib. But we'll have to look at more mature data as time passes.  Dr. Christian Kollmannsberger: Wow. Thank you, Neeraj. So, it sounds like that was a very positive trial, and it's potentially practice-changing. One of the concerns is always safety and toxicity. So can you tell us whether there were any new safety signals, and can you tell us more about the common adverse events that were noticed in TALAPRO-2? Dr. Neeraj Agarwal: No discussion is complete without talking about safety results, so I'm glad you asked me, Christian. The most common dose-affecting toxicity, if you will - so toxicities which led to dose modification and dose discontinuation of talazoparib were cytopenias, as we expect from this class of agents. So anemia, neutropenia, thrombocytopenia, these were the common toxicities. In fact, rate with anemia was 46.5%. Neutropenia and cytopenia were much less common.  I would like to highlight one fact which also came up during the discussion section after our oral presentation. The qualifying criteria for entry in this trial was a hemoglobin of 9-gram percent. And 49% of patients had grade 1 to 2 anemia at baseline, that is before starting treatment with talazoparib. So, we knew that if you mandate dose reduction, a lot of patients will not get adequate dosing of talazoparib. So, we waited for grade 3 anemia and then instituted dose reduction. And that I thought personally was a good strategy because the grade 3 anemia happened after a median duration of three months, 3.3 months to be more precise. And then, these patients underwent protocol-mandated dose reduction, following which the dose discontinuations were quite low actually. Only 8.3% patients discontinued talazoparib because of anemia, and the median dose intensity or median relative dose intensity of talazoparib in the talazoparib arm remained quite high at more than 80%, which translates to a talazoparib dose of 0.4 milligram daily when the starting dose was 0.5 milligram. So those were the hallmark of toxicities.   I do like to mention that those grade 3, 4 toxicities which are more known to affect the quality of life of our patients, such as grade 3, 4 anorexia, fatigue, nausea and vomiting, they were quite rare, happening in 1 to 4% patients who were on talazoparib. So overall, regarding the side effects, they were manageable, there were no new safety signals, and we could maintain adequate talazoparib dosing with dose reduction, which happened quite early during the protocol treatment.  Dr. Christian Kollmannsberger: Thank you, Neeraj. Very impressive results indeed. The patient population included in TALAPRO-2 was very similar to those included in the PROpel phase 3 trial, which tested the combination of abiraterone and olaparib in the first-line mCRPC setting. So, I'd like to just mention that we also saw LBA16 on the PROpel study, which was the final overall survival in PROpel, which was presented by Noel Clarke. So PROpel, as you know, was a randomized phase 3 trial evaluating efficacy and safety of olaparib plus abiraterone versus placebo plus abiraterone as first-line therapy for mCRPC in the first-line metastatic castration resistance setting. The enrollment in that study was independent of known defects in the homologous recombination repair gene pathway in contrast to other studies, such as MAGNITUDE, which tested the biomarker upfront. A total of 796 patients were randomly assigned to either olaparib plus abiraterone or placebo plus abiraterone. And we saw similar results, significant radiographic progression-free survival with olaparib plus abiraterone in PROpel, which was the primary endpoint similar to TALAPRO-2, and that was published last year in the New England Journal of Medicine Evidence.  Now, this abstract presented here at ASCO GU reported on overall survival with an overall survival majority of 47.9% and showed that with the addition of the PARP inhibitor olaparib to abiraterone, a statistically non-significant but clinically meaningful improvement in overall survival of about seven months were achieved compared to standard of care in abiraterone alone. The numbers were 42.1 versus 34.7 months in the all-comers population of patients in the first-line mCRPC setting. Importantly, I think the median overall survival of more than 42 months really represents the longest reported median overall survival thus far in a phase III trial for first-line metastatic castration-resistant prostate cancer. Although the median overall survival for the non-HRR group remains not statistically significant, with a hazard ratio of 0.89. Dr. Neeraj Agarwal: Such a great synopsis of the PROpel result data. Thank you, Christian, for highlighting these results. As we know, the combination is already approved by the EMA, the European Medical Agency, for patients in the first-line mCRPC setting who are not candidates for docetaxel chemotherapy. If this combination is approved by the FDA, we may have one more therapeutic option for our patients in first-line mCRPC.  So, just continuing on the PARP inhibitors, there was one more oral presentation with PARP inhibitor rucaparib by Dr. Alan Bryce from the Mayo Clinic, Arizona. This was Abstract 18 on the primary result of the TRITON3 trial. So to complete our PARP inhibitor section, I would like to summarize the result of the TRITON3 trial, which was a randomized phase III trial evaluating rucaparib versus physician choice, which notably included docetaxel in addition to abiraterone or enzalutamide in patients with chemotherapy-naive mCRPC with BRCA1, BRCA2 or ATM alterations. These patients had disease progression after having one novel hormonal therapy, or we call them second-generation androgen pathway inhibitors in any setting. So these patients had to have disease progression on a novel hormonal therapy.   In the BRCA subgroup and the subsequent intention to treat the population, the primary endpoint tested first was radiographic progression-free survival, and overall survival was the key secondary endpoint. The subgroup of patients with BRCA-altered disease had a median rPFS of 11.2 months with rucaparib compared to 6.4 months with physician choice of treatment - looks like almost doubling of the rPFS with the rucaparib. In the overall ITT population, median rPFS was 10.2 months with rucaparib and 6.4 months with the physician's choice of treatment. Although the overall survival data are immature, we still see a trend for improved overall survival with rucaparib. Regardless, the study clearly demonstrates the value of rucaparib for treating BRCA1 and BRCA2-altered mCRPC after disease progression on an androgen receptor pathway inhibitor. So these were the impressive results from the TRITON3 trial.  But before we switch to non-prostate abstract, I would like to complete the prostate cancer discussion by talking about the Abstract 15, which was based on the results of the ARASENS trial presented by Dr. Maha Hussain. As we know, ARASENS is a randomized phase 3 trial evaluating the efficacy and safety of darolutamide plus androgen deprivation therapy plus docetaxel versus androgen deprivation therapy or ADT plus docetaxel. So the triplet of ADT plus darolutamide plus docetaxel being compared to ADT plus docetaxel chemotherapy in patients with newly diagnosed metastatic castration-sensitive prostate cancer. A total of 1,300 patients were randomly assigned to the doublet versus triplet. As presented in the last ASCO GU meeting exactly one year ago, the primary endpoint of the study was met with a significant improvement in overall survival and a 32% reduction in risk of death for patients on the triplet therapy with ADT plus docetaxel plus darolutamide versus ADT plus docetaxel chemotherapy. So triplet therapy was already approved based on these data.  The abstract presented by Dr. Hussain this year is a post-talk analysis where Dr. Hussain and colleagues investigated the impact of triplet therapy across patients with high volume versus low volume per chartered criteria and higher risk versus low risk using latitude trial criteria. And investigators knew that these results would be highly attractive to practicing oncologists who are now choosing treatment based on volume of disease or risk of disease, more commonly, volume of disease.  So, let's come to what was presented this ASCO GU. So, after 1,305 patients in ARASENS, the majority had high-volume disease and high-risk disease. Among patients with high-volume disease, the addition of darolutamide reduced the risk of death by 30% compared with ADT and docetaxel, with a hazard ratio of 0.69. In the risk groups, the addition of darolutamide seems to favor both high-risk and low-risk groups. Among patients with low-volume disease, there was a trend towards improvement in overall survival with the addition of darolutamide, but it did not reach statistical significance. The great news was that there was no new safety signal. So, to summarize these data, the triplet of darolutamide plus ADT plus docetaxel showed superior overall survival compared to doublet of ADT plus docetaxel, with an important caveat that triplet was not compared with any of the modern doublets of ADT plus a second generation androgen receptor pathways inhibitor such as abiraterone, apalutamide, or enzalutamide, or even darolutamide. So, I wish there was a third arm of ADT plus darolutamide.  Having said that, triplet can be considered a standard of care now based on these data for patients with metastatic hormone sensory prostate cancer, where we would be using ADT plus docetaxel chemotherapy. And from this meeting data, this efficacy of triplet can be applied to high-volume disease and all risk disease. And we just need more time to see how the data pans out in low-volume patients with metastatic hormone-sensitive prostate cancer.  Dr. Christian Kollmannsberger: Yes, I completely agree, Neeraj. I think all the data presented in these abstracts are really impressive and will impact our daily clinical practice and our patients more or less immediately. I think the use of PARP inhibitors, whether as a monotherapy or in combination with androgen receptor pathway inhibitors, as well as now the option of triplet therapy in the metastatic castration sensitive setting really offer patients with metastatic prostate cancer new treatment strategies and most importantly, improved survival outcomes. And it is impressive to see how we have pushed the prognosis and the outcomes for our patients with prostate cancer, I would say, in the last five to ten years. And similar to last year, I think the entire Prostate Cancer Day at ASCO GU 2023 was full with impressive data and featured dynamic content throughout the day. Dr. Neeraj Agarwal: Indeed. So, let's move on to bladder cancer. Christian, what are your key takeaways from the bladder cancer studies presented at the meeting? Dr. Christian Kollmannsberger: I think there were interesting abstracts in both the non-muscle-invasive and the muscle-invasive setting and the metastatic setting. So, for example, Abstract 442 was presented by Dr. Andrea Necchi on the cohort B of the phase 2 KEYNOTE-057 trial. As a background here, the standard treatment for high-risk non-muscle-invasive bladder cancer involves transurethral resection of the bladder tumor, a TURBT, followed by intravesical BCG therapy to eradicate any residual disease. And patients who fail to adequately respond to BCG are usually recommended to undergo radical cystectomy. So in the cohort B of the phase 2  KEYNOTE-057 trial that investigated the safety and efficacy of pembrolizumab as a single agent for patients with BCG-unresponsive, high-risk non-muscle-invasive bladder cancer who were ineligible or declined to undergo radical cystectomy, enrolled patients received standard-dose pembrolizumab of 200 milligrams every three weeks for up to 35 cycles. So very common as we do it with other disease sites. And at a median follow-up of 45.4 months, the primary endpoints of disease-free survival at twelve months was 43.5%. The median disease-free survival duration was 7.7 months. These are encouraging results, and we should keep in mind that a radical cystectomy has immense impact on our patients' quality of life. So I think it is important that we do these trials.  Now in order to address potential biases in this phase II trial, such as the underlying heterogeneity of transurethral resection of bladder tumor quality, and to obtain a more comprehensive understanding of pembrolizumab's efficacy relative to a particular control group, we need further evaluation of pembrolizumab in a randomized trial before we can really go for regulatory approval. But overall, I think for the first time in a long time that we seem to be able to move the needle in non-muscle-invasive bladder cancer. Dr. Neeraj Agarwal: Thank you, Christian, for this great overview. Could you please also share the findings presented by Dr. Matt Galsky on Abstract 443? Dr. Christian Kollmannsberger: Of course, Neeraj. Abstract 443, presented by Matt Galsky, reported the extended follow-up results from the CheckMate 274 trial, which looked at another very important field where we haven't made that much progress, which is the adjuvant setting. And CheckMate 274 examined adjuvant nivolumab compared to placebo for patients with high-risk resected muscle-invasive urothelial carcinoma. In this trial, nivolumab was given at 240 milligrams every two weeks or placebo every two weeks for up to one year of treatment. After following up with patients for a median of 36.1 months, the study found that those who received nivolumab had a median DFS of 22 months compared to only 10.9 months for those who received placebo among the ITT patients. So basically, a doubling of the DFS with the addition of adjuvant nivolumab.  The results were particularly notable for patients with high PD-L1 expressions or PD-L1 expression of 1% or more, as those who are treated with nivolumab had a median DFS of 52.6 months, which was six times higher than the DFS in the control group where patients received placebo, which was only 8.4 months. And I think that is truly impressive. One year of adjuvant therapy with nivolumab continues to show a sustained disease-free survival benefit over a period of three years in both the ITT and the PD-L1-high patient population. In my view, these results reinforce the utility of nivolumab in the adjuvant urothelial carcinoma setting after surgery. And it will be interesting to see how the overall survival pans out in this study.  So, Neeraj, moving on to kidney cancer, what were your key takeaways from these studies on kidney cancer presented in this meeting?  Dr. Neeraj Agarwal: So, there were exciting results presented from multiple studies in this area as well. For example, Abstract 603 presented by Dr. Mauricio Burotto, senior author was, Dr. Toni Choueiri on the three-year follow-up from the phase 2 CheckMate-9ER trial. So, in this trial, patients were randomized one-to-one to nivolumab 240 milligrams every two weeks, plus cabozantinib 40 milligrams daily versus sunitinib 50 milligrams daily for four weeks, and it was a six-week cycle for sunitinib until disease progression or unacceptable toxicity. So this was the design of the phase 3 CheckMate-9ER trial. And after a median follow-up of three years, the benefit of nivolumab plus cabozantinib remained consistent with previous follow-ups. So, as we know, these data have been presented in the past, also published in the New England Journal of Medicine. But this meeting was a clear follow-up of these data.  Notably, the median overall survival of patients treated with cabozantinib plus nivolumab in the ITT population, which included all favorable intermediate and poor IMDC score patients, was significantly improved at 49.5 months compared to 35.5 months in the sunitinib arm. It is so heartening to see that median overall survival breaching the four-year mark in our patients with metastatic RCC in a consistent fashion. We saw similar data with the combination of ipilimumab plus nivolumab recently. And as these trials are maturing, we are probably going to see more combinations breaching this four-year mark. So importantly, no new safety signals emerged with the additional follow-up in either arm. And I think these results provide further support for the use of cabozantinib plus nivolumab as a first-line treatment option for patients with metastatic or advanced renal cell carcinoma. Dr. Christian Kollmannsberger: Indeed, I think it is extremely impressive what we've seen over the last 15 years in metastatic kidney cancer, going from a median overall survival of about a year to now more than four years. I think that is a great achievement, and we can see it on a daily basis in our clinical practice.  Now, before we wrap up, I would like to highlight another potentially practice-changing trial, LBA602, which titled, “Results from Phase 3 Study of 89Zr-DFO-Girentuximab for PET/CT Imaging of Clear Cell Renal Cell Carcinoma: The ZIRCON Trial” presented by Dr. Brian Shuch. The background of this is that the detection of renal masses poses a challenge due to the limitations of diagnostic options such as imaging and biopsy. And we often, in clinical practice, are confronted with "What exactly is this?" And what's even more importantly, “What's the histology of this?” And a non-invasive, accurate method is needed for pre-treatment risk stratification. Girentuximab, a monoclonal antibody that targets carbonic anhydrase IX expressed on clear cell renal cell carcinoma, can obviously now aid in the differentiation between clear cell renal cell carcinomas and other renal lesions when radiolabeled with this new agent.  The ZIRCON trial was open-label and designed to include patients with renal masses up to 7 cm in size or clear tumor stage cT1 who were scheduled for partial nephrectomy within 90 days of planned TLX250-CDx administration. The enrolled patients received a single intravenous dose of girentuximab on day 0 and underwent FDG PET/CT imaging on day 5 before their scheduled surgery. And the co-primary endpoints were to assess the sensitivity and specificity of girentuximab PET/CT imaging for detecting clear cell renal cell carcinoma in patients with indeterminate renal masses, with histology as the reference standard, which I think is a great way to test these agents because you get 100% validation.  In the primary analysis of 284 patients, the average sensitivity and specificity across all three central readers were 86% and 87%, respectively, exceeding the prespecified thresholds. The positive and negative predictive values were 93.4% and 78%, respectively. And with very few related adverse events reported, the study affirms that girentuximab PET/CT is safe and effective in identifying clear cell renal cell carcinoma in patients with indeterminate renal masses. And the findings hold potential for developing optimal management strategies for patients with indeterminate renal masses. I think this is important that we add a non-invasive method to this because we are confronted on a regular basis with patients who either cannot tolerate a biopsy or where the biopsy is indeterminate. And this could potentially be a great tool to help us with our pre-treatment planning of our treatment strategy. Dr. Neeraj Agarwal: Wow. So, it looks like a new PET scan using a unique tracer and antibody to detect the clear cell renal cell carcinoma with high specificity and sensitivity. It reminds me of drawing a crude analogy from the PSMA PET scan in prostate cancer. And hopefully, we will be able to use these newer scans that we call TLX250-CDx PET/CT scan. I hope they have a simpler name for this very soon. Or maybe follow up for patients who had kidney cancer, localized kidney cancer taken out by radical surgery, and then we are following them. And sometimes, we don't know if a small lung nodule is metastatic or not. And these kinds of imaging studies may help us down the line in monitoring those patients as well. So indeed, very exciting progress not only in the therapeutic area now but also in diagnostic fields at this GU ASCO.   So with that, we have seen multiple abstracts on prostate, bladder, and kidney cancer with real impact on how we practice medicine. Thank you, Christian, for sharing your insight with us today. It is an exciting time in GU Oncology, and we appreciate you taking the time to contribute to the discussion. Thank you so much.   Dr. Christian Kollmannsberger: Thank you, Neeraj, thank you for having me. And I completely agree it remains an exciting time in GU oncology.   Dr. Neeraj Agarwal: And thank you to our listeners for joining us today. You will find links to the abstracts discussed today on the transcripts of this episode.  Finally, if you value the insights that you hear on the ASCO Daily News Podcast, please take a moment to rate, review, and subscribe wherever you get your podcasts.   Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.   Find out more about today's speakers:   Dr. Neeraj Agarwal  @neerajaiims Dr. Christian Kollmannsberger Follow ASCO on social media:    @ASCO on Twitter    ASCO on Facebook    ASCO on LinkedIn    Disclosures:   Dr. Neeraj Agarwal:    Consulting or Advisory Role: Pfizer, Bristol-Myers Squibb, AstraZeneca, Nektar, Lilly, Bayer, Pharmacyclics, Foundation Medicine, Astellas Pharma, Lilly, Exelixis, AstraZeneca, Pfizer, Merck, Novartis, Eisai, Seattle Genetics, EMD Serono, Janssen Oncology, AVEO, Calithera Biosciences, MEI Pharma, Genentech, Astellas Pharma, Foundation Medicine, and Gilead Sciences   Research Funding (Institution): Bayer, Bristol-Myers Squibb, Takeda, Pfizer, Exelixis, Amgen, AstraZeneca, Calithera Biosciences, Celldex, Eisai, Genentech, Immunomedics, Janssen, Merck, Lilly, Nektar, ORIC Pharmaceuticals, crispr therapeutics, Arvinas   Dr. Christian Kollmannsberger: None disclosed  

JAF地方選手権 岡山国際サーキットトライアル選手権Rd.4(最終戦)CT1クラス(12/3)のライバルについて。そして、C1 Racingのアントニオ選手をご紹介。カートや自動車レースの海外事情も。 【パーソナリティー】林佑樹（C1 Race主催者）【ナビゲーター】千太郎（現役走り屋芸人) & 碧井エリ（MC・ボーカリスト）※プロフィールの詳細は番組概要欄へ【HP】https://www.c1race.com/【Instagram】https://www.instagram.com/p/CiqPNY0PilT/?utm_source=ig_web_copy_link【Twitter】https://twitter.com/c1race/ ←番組へのご質問は、Twitterのダイレクトメッセージよりご応募ください♪

話題の「○○オタブルー」がいよいよ納車されました。岡山国際サーキットトライアル CT1クラス出場に向けた、インプレッサの改造計画とは？ 岡山国際サーキット コースレコードhttp://www.okayama-international-circuit.jp/guide/pdf/rec_4.pdf REON サーキット https://reon.org/ 【パーソナリティー】林佑樹 (C1 Race主催、C1 Racing代表) 【ナビゲーター】千太郎 (現役走り屋芸人) & 碧井エリ (MC・ボーカリスト) ※プロフィールの詳細は番組概要欄へ 【HP】https://www.c1race.com/ 【Instagram】https://www.instagram.com/p/CiYPECJvvBe/?utm_source=ig_web_copy_link 【Twitter】https://twitter.com/c1race/ ←番組へのご質問は、Twitterのダイレクトメッセージよりご応募ください♪

THE NASH Tsunami audience came to know Jörn Schattenberg in the Fall of 2020 when he shared a paper he had recently co-authored on why NASH drug trials failed. This week, the same group that discussed that paper – Jörn, Stephen Harrison, Louise Campbell and Roger Green – reflect on what has improved in the intervening time period and what has not. After Roger Green sets the stage for this conversation, Jörn reflects back on the 2020 paper he co-authored with Joost Drenth and considers important changes in patient screening since then.  In his own words, “The way we use biomarkers and AI to augment outcomes has changed the field dramatically.” Whereas biopsy used to be the core method used to recruit patients, Jörn notes that many practitioners now rely on NITs to assess the patient's likelihood of screening into a trial before conducting a biopsy. The result is a significant reduction in non-essential biopsies. Stephen follows Jörn by discussing ways his own practice has benefitted greatly from the developing a prescreen strategy that relies heavily on NITs. Instead of doing "five biopsies a day, maybe 25 or 30 a week," he now starts with FAST scores and cT1 and, if these seem promising, moves to multiparametric MRI before deciding who to biopsy. Specifically, his practice is now able to utilize VCTE (FibroScan) and other NITs to mine data in real time and refer patients to the proper clinical trial as a result. As the episode winds down, Stephen alludes to the idea of "mid-trial corrections" in pre-biopsy NIT screening criteria and advances in how biopsies are read in trials today as other areas where procedure has improved markedly.

As the NASH pandemic grows in the number and diversity of patient cases, one patient group receiving increased notice includes patients with "lean NASH," those with "normal" BMI levels (BMI

As the NASH pandemic grows in the number and diversity of patient cases, one patient group receiving increased notice includes patients with "lean NASH," those whose BMI levels are "normal." Last month, Gastroenterology published Best Practice recommendations for diagnosing and treating lean NASH. Two of the authors, Drs. Michelle Long and Mazen Noureddin, were good enough to come on the podcast to share the thinking behind this article along with its key observations and recommendations.This conversation starts with Roger Green asking Michelle and Mazen how they came to write this piece and how the paper came together working with co-author, Dr. Joseph Lim. First, as Michelle notes, "we had to all get on the same page," on the issue of the highest BMI that would be considered lean or, more precisely, not overweight. From there, the team outlined 15 Best Practices based on clinical experience, and set out to refine these based on relevant literature and recommendations from colleagues and reviewers. The co-authors note that while little of what they learned while preparing this paper was surprising, it forced them to focus on creating a fairly simple set of stepwise goals for clinicians to follow.  Louise Campbell joins the conversation to praise the simplicity and clarity of the Best Practices chart the co-authors created. After noting that this algorithm is not very different from others,  Mazen goes on to mention "a couple of things...that we're proud of:" identification of high-risk patients based on age (over 40) or presence of Type 2 diabetes. He also notes that they provided greater clarity around more advanced non-invasive tests like ELF, MAST, FAST, MEFIB, MRI, and cT1.The conversation shifts to focus on the recommendation to retest every 6 or 12 months. Louise notes this approvingly. The group agrees that screening T2D patients annually using FIB-4 is not very different than screening annually for eye, kidney or neurological complications. Roger Green joins the conversation to suggest a 3-5 year follow-up recommendation is not patient-centric, but might calm payers concerned about skyrocketing costs of treating Fatty Liver disease. Mazen shares his expectation that yearly evaluation will be cost-effective and patient-centric. Roger shares an informal belief he has developed that whether due to later stage diagnoses or different disease pathogenesis, lean NASH patients might be more costly because patients progress to cirrhosis more quickly after the original diagnosis. Michelle tends to agree but notes that more research is needed on this.Next, the conversation shifts toward diagnostic approaches. Roger mentions the possible benefit of the "Fibrosis First" method that Ian Rowe discussed the previous week (S3, E39), particularly appropriate when primary care providers observe danger signs in lean patients. Mazen points to extremely elevated liver enzyme levels (ALT of 80 or 90). Michelle agrees, but notes that most of her lean NASH patients are diagnosed in an ED with complications of cirrhosis. The group then spends time asking what might make primary care providers comfortable testing for fibrosis, even if only to pass the patient on to the appropriate specialist.  Roger asks what different groups can learn from this paper. Michelle states that this is a clear call for more research. Mazen points to Table 2 in the paper, which lists other diseases that hepatologists should consider when evaluating these patients. He continues to state that the document is helpful for non-hepatologists and hepatologists alike. Finally, he points out that clinical trials are pivotal for these patients. The last several moments focus on how to ask patients about alcohol consumption and then the closing question. Michelle notes the importance of using lists and tables in the paper to guide the special issues in treating these patients. 

In S3E5 Mike welcomes his musical good buddy James Park onto the podcast where they discuss their mutual love of college hoops, music, the performance art form that is pub trivia and then take a deep (dish) dive on one of their favorite forms of sustenance: pizza.Follow the podcast on Twitter: @friendsofmikedEmail the podcast at talkingfriendship@gmail.comKey moments from the pod: 0:30: Mike welcomes listeners to S3E5 featuring Mike's good buddy James Park.1:30: Mike corrects a major pronunciation error he personally made in Episode 4.5 of Season 3.3:00: Mike talks about what's going on with him, which essentially doubles as a quick recap of Season 3 so far, including a reference to a recent walkabout he took in his neighborhood, and a hearty thank you to the listener community.6:15: Mike then identifies a classic (literally) song that features an instrument James  knows really, really well in the violin as a tribute to James.10:30: Mike welcomes James Park into the virtual podcast studio.11:35: James gives his life story,  Mike brings up a touchy subject about how the NCAA left his hometown.  James then talks about his passion for music and the violin and why Ann Arbor is a great town for music.17:20: James talks about his oldest and dearest friend (the infamous Rob/Robert) and the guys prove a math equation on friendship.22:45: The guys talk about the last time they saw each other (spoiler alert: it was watching America's national pastime).26:00: The guys trace the origin of their friendship back to a single event, a very orderly but also fun work party in 2016 and what Mike was wearing to that party (a tuxedo tracksuit).29:30: Mike and James talk a bit about their shared passion for the sport of college hoops, with James' loyalties lying with a bird and Mike's with a mammal.  They also get into a piece of memorabilia in Mike's basement pub that requires a trigger warning for James before he sees it. 35:10: The guys then break down one of their all time favorite activities known as Pub Trivia/Pub Quiz and how their team Prune Tracy (EAT YOUR PRUNES!!) became legends in the late 2010's around the Eastern Michigan trivia scene.40:40: James throws down the infamous “7 Day Trivia Challenge” to Mike and he…..accepts!44:00: The guys discuss one of their favorite shared foods (a little known delicacy known as pizza), how they fell in love with it, then break down their favorite pizza places they've ever been to.  The discussion covers a ton of ground on “pie”, including discussing why New Haven, CT is known as a pizza hotbed, where Mike would get pizza before school dances, where James would get pizza with friends while playing music and why they both love Chicago pizza.48:00: Pizzeria Uno, Overland Park, Kansas49:50: Bricks Pizza, Chicago, IL52:15: Frist Campus Center on the campus of Princeton University in Princeton, NJ54:20: Little Caesars, Allen Park, MI (includes a non-sequitur from James on an amazing Japanese TV show called “Old Enough”)59:00: Koronet Pizza, New York, NY1:02:30: Buddy's Pizza, Dearborn, MI1:05:20: Modern Apizza, New Haven, CT1:11:20: Frank Pepe's, New Haven, CT1:13:30: Pequod's, Chicago, IL1:17:00: James then drops some knowledge as to how to keep a friendship going.1:19:00: James updates the listeners on what he's excited about coming up in his life.1:21:00: Mike takes James through the (not so) Rapid Fire segment, including talking about when James' favorite music venues, his top feature of living in Ann Arbor, MI (spoiler alert: it's not the roads), the trivia topic he feels most comfortable answering (including how he used to con his mom to get Little Debbie snacks in order to learn about US Presidents), and where he'd love to travel to soon that he's never been to.

This is the second of a two-part discussion on the shared theatre environment, featuring a panel of both surgeons and anaesthetists reaching across the curtain to reflect on the cultural similarities and differences between two specialties that can often seem divided despite working mere feet apart. Following from the previous discussion on theatre culture, this episode will focus on the differences in training cultures between the two specialities. These episodes are presented by anaesthetic consultant Deirdre Conway, orthopaedic ST3 Karen Chui, anaesthetic ST5 Stuart Edwardson and CT1 surgical trainee Karishma Shah. This is the last episode of the Theatre for 2021! We will return in the New Year with more dispatches from the world of surgical innovation.

This is the first of a two-part discussion on the shared theatre environment, featuring a panel of both surgeons and anaesthetists reaching across the curtain to reflect on the cultural similarities and differences between two specialties that can often seem divided despite working mere feet apart. These episodes are presented by orthopaedic ST3 Karen Chui, anaesthetic consultant Deirdre Conway, anaesthetic registrar Stuart Edwardson and orthopaedic CT1 surgical trainee Karishma Shah. This episode focuses on shared theatre culture, while the second part revolves around the distinct training cultures of each specialty. Our panel will return in two weeks' time for the second part of the discussion on training culture.

Global Liver Institute Founder, President and CEO Donna Cryer and her fellow patient and patient advocate Terri Milton join Stephen Harrison, Louise Campbell and Roger Green to discuss the ground-breaking NASH Patient-Focused Drug Development meeting held on November 4, 2021 and the advocates' priorities -- both those who spoke in the PFDD session and others like our panelists -- for changes in regulatory policy and programs.In this conversation, the Surfers and the patient/patient advocate guests share divergent opinions about relative value of drug development vs. support for non-invasive testing as the top advocacy priority. The group wraps up the episode (and this conversation) by discussing the one message each person hopes regulators took from the Patient-Focused Drug Development meeting.

Antaros Medical's Chief Scientific Officer Lars Johansson joins Stephen Harrison, Louise Campbell, and Roger Green to reprise the key points of his recent Paris NASH talk and comment on several other topics.Lars Johansson's Paris NASH presentation, "Innovations in Imaging Assessment of Fibrosis"," introduced his audience to a dynamic, multidimensional view of tools that can show us how the liver works. Rather than focusing on static measurements of "what shouldn't be there," Lars discusses the measurement of "what should" - for example, the interplay of fibrosis and fibrogenesis. Most striking, he describes an array of leading edge and state of the art imaging techniques that shift focus from today's "what shouldn't" targets (fat and fibrosis) to "what should" (functioning hepatocytes, to give one example.) This different viewpoint combines with the novel imaging tools and approaches to create an episode that might leave you repeatedly thinking "Oh, Wow!" Expected to be challenged and exhilarated!Highlights include:12:27 - Stephen Harrison introduces Lars Johansson by discussing the Paris NASH meeting and the session Stephen chaired14:29 - Lars begins his discussion of the Paris NASH paper15:35 - The role of PET tracers in assessing disruptions in liver homeostasis through assessment of hepatic stellate cells and imaging collagen Type I17:58 - Why Stephen sees the kinds of imaging Lars describes as "potentially a game changer" and his "next step": to associate these results with blood-based biomarkers 20:59 - Lars discusses the best interplay of circulating blood biomarkers and PET tracers, and highlights combination therapy development as an area for development22:29 - Stephen suggests that this approach can provide more holistic solutions than histopathology, particularly for metabolic disease and specific sub-types25:04 - Louise discusses the benefit to the patient of using these kinds of technique to move beyond much current biopsy26:25 - Lars's "second piece from Paris" is the use of a gadolinium contrast agent due to its high level of hepatic uptake27:41 - Roger observes that these tools allow us to study the liver as a dynamic system28:24 - Lars discusses why to him, hepatocyte function  is a robust dynamic measure 29:38 - Stephen speculates that these techniques can create knowledge more efficiently than our best measures today and suggests that they will provide greatest value in cirrhosis and advanced fibrosis34:32 - Lars suggests these kinds of techniques might replace for augment HVPG over time and goes on to share an integrated version of how much data these approaches can produce in a single drug trial 36:22 - Louise's "Dare to Dream:" replace biopsy with an easier way to assess path of disease which will allow more efficient screening of more patients37:12 - Roger's "Dare to Dream:"  visualize the liver in the context of the whole patient39:23 - Stephen's "Dare to Dream:" to become cognizant of  how the range of noninvasive tests can help us mold drug development for different phenotypes of patients and separately,  to speed drug development41:09 - Lars's "Dare to Dream:" Bring these techniques to early drug development, which will streamline investment of time and money by improving focus 42:52 - Roger's final question - "The one thing that 'blew everyone's minds' the most."46:40 - Business Section - A listener record; for the first time, a conversation gets more downloads than its episode, update on CME, requests for conferences you would like us to attend

In this weeks Podcast we speak to CT1 at the Crown Decorators Centre in Chesterfield. F1 News Our visit to Topdec in Hemel Hempstead How Much Snagging do you do? Geometric Walls And all the usual, For all the interesting stuff click here https://pod.fan/two-decocators-and-a-microphone-extras      

At one time Eric Hovind, son of Kent Hovind, used to attempt to convince non-believers that God created the universe by presenting evidence. But, his Creation Today ministry has verbally and vocally STOPPED providing evidence for creation. Instead, the show embraces presuppositional apologetics... that is, to merely assume in advance that the Bible is true and that God exists.Is this intellectually honest? What about faith? What about the Bible? Can we prove it? What role should authority play?All clips are copyright the original copyright holders and owners. Used here under fair use for commentary.Logicked - https://www.youtube.com/channel/UCaFNs3ETMvkmy0JahAS6WJACreation Today episodes featured -CT1-15 https://youtu.be/8dXz8a0zlagCT1-19 https://youtu.be/QLoXEYdwgRUCT2-08 https://youtu.be/TUWQLPpFoKoCT2-11 https://youtu.be/LgktZmbpFSQCT2-26 https://youtu.be/fr2SxCKjtfICT3-08 https://youtu.be/md7Q7Ff2eKQCT3-18 https://youtu.be/_dY_9I7ZcZwFollow me athttp://www.twitter.com/paulogia0http://www.facebook.com/paulogia0Support the show (https://www.patreon.com/paulogia)

In this episode of Two Decorators and a Microphone.We launch our MASSIVE Christmas Giveaway - Thank you to Paintshack, CT1, Topdeck, Brewers, Tikkarilla and TesaFor the chance to win some great prizes head over to our Facebook Page https://www.facebook.com/Two-Decorators-and-a-Microphone-103389837773810/Also whats in your trousers? find out what we found in oursHow Organised do you need to be if your a Painter and Decorator?Do we up our game a do the TalkRadio interview?  

In the is podcast we talk about the National Painting and Decorating Show held in Coventry.So if you couldnt make it we hope to bring some of the atmoshere to you via the medium of the podcast.In the first of two episodes we speak to CT1, Tikkarilla, Deltec, The Ladder Association and Kolorbond.We also discuss who we have met and also how the Dulux Select Awards went.For all this and much much more download our podcast PLEASE lol!!!Ryan's Attempt at art?

Michelle Mead and is an Ironman and a Broken Neck Survivor, who always striving for a little more. Her life and times can be defined by decades of competitive sports and arts. Her early years were all about gymnastics, ballet, and dancing. Always competitive; after dancing marathon running became a passion. Completing 10 marathons and top 10 finish at OBX as a master. A friend suggested she might enjoy cycling and racing. Multi-sport and bikes came into her life. She took her love of running and cycling ability to secure a spot on team USA for world championships in Duathlon. Placing 9th in her age group at worlds in distance duathlon. What’s next Ironman! She was 49 and thought let’s go big for the big one at 50! – Completing Ironman Wisconsin was the culmination of dream accomplishment. After Ironman, her loves of bikes turned into racing cyclocross and mountain biking. Then life changed forever in September 2017, she was participating in local bike festival promoting cycling and during a stunt on live television, she fell and broke my neck in 2 places . she her C-1 in half and had 4-5 fusion resulting in paralysis of my upper body extremities. Navigating the “New Me” made Ironman feel easy. Retraining nerves, making arms, hands, and fingers respond was crazy hard. A team of OT and PT at Metro-Health System, Cleveland, Ohio and weeks of intense work made it all happen. she had the goal of getting back to riding again, she made her return to riding at Global Fit Bike Ride Day December 3, 2017. Three months post-accident. Being active and helping others experience the joys of sport has been woven in my lifestyle with mentoring programs and social media groups. She can run and ride now, still recovering with spinal cord issues and another surgery to remove hardware holding her CT1 in place is next. She lives by the motto: Live fear free in the moment each day…small steps forward. linkedin.com/in/michellemead --- Support this podcast: https://anchor.fm/executiveathletes/support

Heute haben wir Bettina Greschner für dich im Interview! Ihre Motivation ist es, Menschen, gutes zu tun und zu zeigen, das ALLES möglich ist! Sie teilt ihre bewegende Geschichte, was ihre Kindheit geprägt hat und welche Schicksalsschläge sie verarbeiten musste. Als Unternehmerin von einem Möbelgeschäft mit integriertem Cafe und Wohnaccessoires und als Mutter von zwei Kindern erhielt sie im Oktober 2011 die Diagnose Brustkrebs. Zudem ging zeitgleich ihr Geschäft bergab. Das war ihr Turningpoint und sie entschied sich dazu, sehr offensiv mit der Diagnose umzugehen. Sie setzte sich intensiv mit der neuen Situation, den Ängste und Nöten auseinander und lebt heute ihre Passion als Coach! Bettina´s konkrete Schritte zum Erfolg: 1. Umfeld aufbauen-suchen-loslassen und klar darüber werden "Wer oder was tut mir gut?!" 2. Mir und meinem Umfeld verzeihen 3. mich selber lieben!!! Shownotes Hier kannst du dich für ein kostenfreies Coaching mit Marina bewerben: www.feminess.de/private-coaching - Hier geht es zu Feminess: http://feminess.de - Werde Teil der Community und tausche dich mit gleichgesinnten Frauen aus: https://www.facebook.com/groups/feminess/ - Erhalte jede Woche neue Videos auf unserem YouTube Kanal: https://www.youtube.com/channel/UCBvWwMkDdxhUDFZDWQPBlEQ?view_as=subscriber - Immer up to date: Finde alle News zu Feminess auf unserer Facebook-Seite: https://www.facebook.com/Feminess/ - Folge uns auf Instagram! https://www.instagram.com/my.feminess/ - Hier kommst du zum aktuellen Blogbeitrag: http://feminess.de/blog Feminess Kongress Sichere dir deinen Gutschein über 20€ auf den nächsten Feminess Kongress. Gehe auf www.feminess.de/kongress und trage bei Buchung den Code Podcast20 ein. Mehr von Bettina Greschner: Bettina´s Geschenk: Ein gutes Zeitmanagement ist super wichtig!!! Dazu habe ich meine 10 besten Tipps in meinem EBook aufgeschrieben: Hier ist für DICH kostenlos mein Buch: "Top 10 mehr Zeit, Klarheit & Struktur" eepurl.com/cT1-fr & Vereinbare jetzt einen Termin für dein Klarheitsgespräch! https://bgreschner.youcanbook.me Facebook: https://www.facebook.com/bettinagreschnercoaching/?ref=bookmarks Dein Weg zu Dir facebook Gruppe: https://www.facebook.com/groups/2114514475442442/?source_id=429362970766099 Instagram: https://www.instagram.com/bettina_greschner/ Podcast:

Wofür investierst DU Deine Zeit? Wie strukturierst DU Deinen Tag und wieviel kostbare schöne Zeit kannst DU für DICH genießen? Wie oft sagst Du dass DU keine Zeit hast?! Täglich bekommen wir 86.400 Sekunden geschenkt. JEDER von uns. Keiner mehr, keiner weniger! Die Frage ist, was und wie nutze ich die Zeit optimal und konzentriert, um gleichzeitig mehr Zeit für die schönen Dinge des Lebens zu genießen? Bis ich für mich die optimale Struktur gefunden habe, was mir geholfen hast und auch DIR sicherlich weiterhilft, hör gern rein... Hier ist für DICH mein Buch "Top 10 mehr Zeit, Klarheit & Struktur" http://eepurl.com/cT1-fr Viel Freude damit! Alles Liebe für Dich, genieße DICH und DEIN Leben, Deine Bettina Besuche mich gern bei Facebook auf meiner Seite. „Dein Weg zu Dir“ P.S. Wenn Dir dieser Podcast gefallen hat, freue ich mich über eine Bewertung bei iTunes, gerne mit 5 Sternen. Ich danke Dir dafür schon einmal im Voraus

In our first episode, we take a look at 1977/78 , The Cheap Trick Concept and a track by track look at their self titled album "Cheap Trick".We also get a cool version of "Reach Out" by the "Strange Way" crew...Thanks Jody Havenot.Let us know what you think and "Like" us on Face Book.http://www.facebook.com/groups/Cheaptalk/If you cannot see the audio controls, listen/download the audio file hereDownload (right click, save as)

Objective: The present study was done to investigate the effects of supersensitive PSA-controlled inductive treatment on positive margins, detection of tumor and epithelial cells in bone marrow of 101 patients with untreated and clinically localized prostatic carcinoma (cT1-3N0M0). Methods: Hormonal treatment was given until PSA (DPD Immulite(R) third-generation assay) reached 500 cases) and using immunohistochemical staining, were unable to detect carcinoma in 15 (15%) specimens. Whereas only 2 (4%) of the 55 cT3 specimens were without detectable tumor, this incidence rised to 28% (13 of 46 prostates) in patients with cT1-2 tumors. Of the initial 29 patients with epithelial cells in bone marrow, only 4 (14%) remained positive after controlled induction and all of them had fewer cells than before. Conclusion: Endocrine induction controlled by a supersensitive PSA assay and continued until reaching PSA nadir is highly effective in clearing surgical margins and eliminating tumor cells from bone marrow. It seems to be clearly superior to the conventional 3 months of pretreatment at least in cT1-2 tumors in respect to surgical margins and detectability of tumor in the resected prostate. A definitive statement about the value of endocrine induction can only be given by prospective randomized studies, with optimal drugs, doses and treatment time. But the conventional 3 months of pretreatment are far from exploiting the possibilities of this therapeutic option.