Podcasts about granada spain

Play Episode Listen Later Mar 9, 2022 59:50

Proved the great antitumoral potential of a compound derived from olives University of Granada (Spain), March 8, 2022 Researchers from the University of Granada (UGR), in collaboration with the universities of Barcelona and Jaen, have brought to light the antitumoral nature of maslinic acid (a compound derived from olives) in Caco-2 p53-deficient colon adenocarcinoma cells in the short term. Maslinic acid (MA) is a natural triterpene found in high concentrations in the waxy skin of olives. The results of this research, recently published in the renowned PloS ONE magazine, show without a doubt how maslinic acid is capable of early inducing the extrinsic cellular death pathway in Caco-2 cells that don't express protein p53 (known by its pro-apoptotic capacity). In previous works, professor Lupiáñez Cara's research team had reported that maslinic acid induces apoptotic cell death via the mitochondrial apoptotic pathway in cancer cell lines. (NEXT) Study finds that Nordic diet lowers cholesterol and blood sugar, even if you don't lose weight University of Copenhagen, March 8, 2022 A healthy Nordic diet can prevent a range of diseases. Until now, the health benefits that researchers had attributed to a Nordic diet primarily focused on weight loss. But in a new study, University of Copenhagen researchers and their Nordic colleagues found clear evidence that a Nordic diet can lower blood sugar and cholesterol levels even without weight loss. In particular, they point to the composition of dietary fats as a possible explanation for the diet's positive effects. Berries, veggies, fish, and whole grains: These are the main ingredients of the Nordic diet concept that for the past decade, has been recognized as extremely healthy, tasty and sustainable. The diet can prevent obesity and reduce the risk of cardiovascular disease, type 2 diabetes, high blood pressure and high cholesterol. Until now, Nordic diet research has primarily been linked to the diet's positive health effect following weight loss. But a new analysis conducted by University of Copenhagen researchers, among others, makes it clear that a Nordic diet has positive health benefits, regardless of whether one loses weight or not. (NEXT) Study finds distinct biological ages across individuals' various organs and systems Beijing Genomics Institute and Lobachevsky State University (Russia), March 8, 2022 It's common to say that someone looks either younger or older than their chronological age, but aging is more than skin deep. Our various organs and systems may have different ages, at least from a biological perspective. In a study published March 8 in the journal Cell Reports, an international team of investigators used biomarkers, statistical modeling, and other techniques to develop tools for measuring the biological ages of various organ systems. Based on their findings, the researchers report that there are multiple "clocks" within the body that vary widely based on factors including genetics and lifestyle in each individual. Most human aging studies have been conducted on older populations and in cohorts with a high incidence of chronic diseases because the aging process in young healthy adults is largely unknown and some studies have suggested that age-related changes could be detected in people as young as their 20s, we decided to focus on this age range." (NEXT) Treating heart attacks with a medium chain fatty acid University of Michigan, March 8, 2022 A medium-chain fatty acid might one day help protect against heart attack injuries. In this publication, we target the interplay between energy metabolism and epigenetics mediated by the medium chain fatty acid 8C." Wang and colleagues were able to protect against heart attack injury in rat models with octanoic acid, an eight carbon (8C) medium chain fatty acid, as well as a few other metabolites. Those fatty acids produced acetyl-CoA, a building block for energy metabolism, which a stressed heart desperately needs. The idea is that a physician would administer this therapy to a person once they arrive at the hospital after having a heart attack, to reduce further injury and improve heart function during recovery, he says. (NEXT) Stress damages the movement centers in the brain University of Bonn (Germany), March 8, 2022 Stress seems to have a negative effect on the learning of movements—at least in mice. This is the conclusion of a recent study at the University of Bonn. According to the study, the neurons of rodents lose some of their contacts with other neurons after stress. The animals also developed motor deficits. The results may be useful for earlier diagnosis and improved therapy of stress-related diseases such as depression. They also document that stress leaves traces in the brain—possibly permanent ones. The study appeared in the journal Translational Psychiatry.Chronically stressed people often show abnormalities in their motor skills, such as poorer fine motor control. The researchers came across a conspicuous feature: after the stressful situation, the neurons studied lost some of their synapses—these are the contacts to other nerve cells. During learning processes, new synapses are usually formed or existing ones are strengthened. Instead, the stressed rodents lost up to 15 percent of their contacts. (OTHER NEWS) Lead exposure in last century shrunk IQ scores of half of Americans Duke University, March 7, 2022 In 1923, lead was first added to gasoline to help keep car engines healthy. However, automotive health came at the great expense of our own well-being. A new study calculates that exposure to car exhaust from leaded gas during childhood stole a collective 824 million IQ points from more than 170 million Americans alive today, about half the population of the United States. The findings suggest that Americans born before 1996 may now be at greater risk for lead-related health problems, such as faster aging of the brain. Leaded gas for cars was banned in the U.S. in 1996, but the researchers say that anyone born before the end of that era, and especially those at the peak of its use in the 1960s and 1970s, had concerningly high lead exposures as children. The team's paper appeared the week of March 7 in the journal Proceedings of the National Academy of Sciences. Lead is able to reach the bloodstream once it's inhaled as dust, or ingested, or consumed in water. In the bloodstream, it's able to pass into the brain through the blood-brain barrier, which is quite good at keeping a lot of toxicants and pathogens out of the brain, but not all of them. One major way lead used to invade bloodstreams was through automotive exhaust. (NEXT) Amazon rainforest is losing resilience: New evidence from satellite data analysis Potsdam Institute for Climate Impact Research (Germany), March 7, 2022 The Amazon rainforest is likely losing resilience, data analysis from high-resolution satellite images suggests. This is due to stress from a combination of logging and burning – the influence of human-caused climate change is not clearly determinable so far, but will likely matter greatly in the future. For about three quarters of the forest, the ability to recover from perturbation has been decreasing since the early 2000s, which the scientists see as a warning sign. The new evidence is derived from advanced statistical analysis of satellite data of changes in vegetation biomass and productivity. “Reduced resilience – the ability to recover from perturbations like droughts or fires – can mean an increased risk of dieback of the Amazon rainforest. The Amazon rainforest is a home to a unique host of biodiversity, strongly influences rainfall all over South America by way of its enormous evapotranspiration, and stores huge amounts of carbon that could be released as greenhouse gases in the case of even partial dieback, in turn contributing to further global warming. This is why the rainforest is of global relevance. The Amazon is considered a potential tipping element in the Earth system and a number of studies revealed its vulnerability.

The Gary Null Show - 03.02.22

Stories in Small Business

Play Episode Listen Later Mar 2, 2022 55:50

30-60 mins of weekly muscle strengthening activity linked to 10-20% lower death risk Tohoku University School of Medicine (Japan), March 1, 2022 Between 30 and 60 minutes of muscle strengthening activity every week is linked to a 10-20% lower risk of death from all causes, and from cardiovascular disease, diabetes, and cancer, in particular, finds a pooled data analysis of the available evidence, published online in the British Journal of Sports Medicine. The findings are independent of aerobic exercise. But the analysis points to a J-shaped curve for most outcomes, with no conclusive evidence that more than an hour a week of muscle strengthening activity reduces the risk further still. Examples of these activities include lifting weights; working with resistance bands; push-ups, sit-ups, and squats; and heavy gardening, such as digging and shoveling. (NEXT) Study finds lower oxidative stress in children who live and study near green spaces Barcelona Institute for Global Health, March 1, 2022 A study led by the Barcelona Institute for Global Health (ISGlobal), has analyzed, for the first time, the relationship between exposure to different green spaces and oxidative stress in children. The study concluded that greater exposure to vegetation is associated with lower levels of oxidative stress and that this association is observed regardless of the children's physical activity. (NEXT) Depression is more than a mental disorder—it affects the whole body University of Granada (Spain), March 1, 2022 An international team of researchers has scientifically proven for the first time that depression is more than a mental disorder—it causes important alterations of the oxidative stress, so it should be considered a systemic disease, since it affects the whole organism. The results of this work, published in the renowned Journal of Clinical Psychiatry magazine, could explain the significant association that depression has with cardiovascular diseases and cancer, and why people suffering from depression die younger. (NEXT) Milk may exacerbate MS symptoms University of Bonn (Germany), March 1, 2022 Multiple sclerosis sufferers often complain of more severe disease symptoms after consuming dairy products. Researchers at the Universities of Bonn and Erlangen-Nuremberg have now found a possible cause for this. According to the study, a protein in cow's milk can trigger inflammation that targets the "insulating layer" around nerve cells. The study was able to demonstrate this link in mice, but also found evidence of a similar mechanism in humans. The researchers therefore recommend that certain groups of sufferers avoid dairy products. The study has now been published in the journal PNAS. (NEXT) Study Reveals Anthocyanins in Strawberries Improve Insulin Resistance Illinois Institute of Technology, March 1, 2022 A new study published in Molecular Nutrition & Food Nutrition found that anthocyanin-rich strawberries may improve insulin sensitivity. Insulin resistance (IR) is a hallmark of metabolic syndrome and a risk factor for heart disease and type 2 diabetes. Researchers observed the effect of anthocyanins on the postprandial insulin response of 21 obese adults with insulin resistance. Subjects were served a typical 'Western-style' meal high in carbohydrates and fat plus a beverage that contained freeze-dried whole strawberry powder. The beverages were controlled for fiber, and the amount of strawberry powder ranged from 0 grams to 40 grams (equivalent to 3 cups of fresh strawberries). When subjects drank the most concentrated beverage, they didn't produce as much insulin as when they drank the least concentrated versions. In other words, they didn't need as much insulin to metabolize their meal after drinking the anthocyanin-rich strawberry shake. While the exact mechanisms are unclear, strawberry anthocyanins may alter insulin signaling at a cellular level. (OTHER NEWS) The Consequences of Humiliating Russia Russia's actions in Ukraine are to a great extent the culmination of the numerous humiliations that the West has inflicted on Russia over the past 30 years Michael Brenner, CONSORTIUM NEWS. February 28, 2022 The Mafia is not known for its creative use of language beyond terms like “hitman,” “go to the mattresses,” “living with the fishes” and suchlike. There are, though, a few pithy sayings that carry enduring wisdom. One concerns honor and revenge: “If you are going to humiliate someone publicly in a really crass manner, make sure that he doesn't survive to take his inevitable revenge.” Violate it at your peril. That enduring truth has been demonstrated by Russia's actions in the Ukraine which, to a great extent, are the culmination of the numerous humiliations that the West, under American instigation, has inflicted on Russia's rulers and the country as a whole over the past 30 years. They have been treated as a sinner sentenced to accept the role of a penitent who, clad in sackcloth, marked with ashes, is expected to appear among the nations with head bowed forever. No right to have its own interests, its own security concerns or even its own opinions. Few in the West questioned the viability of such a prescription for a country of 160 million, territorially the biggest in the world, possessing vast resources of critical value to other industrial nations, technologically sophisticated and custodian of 3,000 + nuclear weapons. No mafia don would have been that obtuse. But our rulers are cut from a different cloth even if their strut and conceit often matches that of the capos. The West nostalgically celebrates the Yeltsin years as the Golden Age of Russian Democracy – an age when life expectancy dropped sharply, when alcoholism rose and mental health declined, when the tanking economy threw millions into poverty, when the oligarchs strutted their stuff, when the presidential chauffeur was the most influential man in the country, and when everyone was free to shoot his mouth off since nobody else heard him in the din of their own voices. Vladimir Putin, of course, was made of sterner stuff. He put an end to the buffoonery, successfully took on the Herculean task of reconstituting Russia as a viable state, and presented himself as ruler of an equal sovereign in cultivating relations with his neighbors. In addition, he insisted that the civil rights and culture of Russians stranded in the Near Abroad be respected. Still, he gave no sign by word or deed that he contemplated using coercive means to restore the integration of Russian and Ukraine that had existed for more than 300 years. True, he opposed Western attempts to sever the ties between the two by incorporating Ukraine into their collective institutions – most notably the NATO declaration of 2008 stating that Ukraine (along with Georgia) were in the alliance's antechamber being readied for entrance. Putin's restraint contrasted with the audacity of Washington and its European subordinates who instigated the Maidan coup toppling the democratically elected president and promoting an American puppet in his place. In effect, the United States has been Ukraine's overseer ever since – a sort of absentee landlord. This attitude has progressively lowered the bar on accusation and insult directed at Russia and Putin personally. For Hillary Clinton he was “a new Hitler” as far back as 2016, for Joe Biden he was a “killer,” for Congress members a Satan using a bag of diabolical instruments to corrupt and destroy American democracy. For all of them, a tyrant turning Russia back to the political Dark Ages after the glowing democratic spring of the Yeltsin years, an assassin – albeit an inept one whose targeted victims somehow survived in unnatural numbers, for the Pentagon a growing menace who moved rapidly up the enemies list – displacing Islamic terrorism by 2017 and vying with China for the top spot ever since. The obsession with Putin the Evil spread as Washington pushed its allies hard to join in the denunciation. The grossness of their personal attacks on Putin matched the ever-expanding scope of the accusations. In recent years, no election could be held in Europe without the leveling of charges that the Kremlin was “interfering” by some unspecified means or other – and at Putin's personal direction. The absence of evidence was irrelevant. Russia became the pinata there to be smashed whenever one felt the urge or saw a domestic political advantage. Michael Brenner is a professor of international affairs at the University of Pittsburgh.

130. Turning Content as an Accountability Tool into a Business with Paul Churchill

Play Episode Listen Later Jun 28, 2021 42:39

You went into your business as a way to help and support other people. So many of the clients I work with have started their business from a personal passion, and a desire to make a positive change in peoples' lives. Today's episode is different from any other episode I've done before. You may not recognize our guest, but he's a master at online content. I discovered Paul Churchill last summer through his Recovery Elevator podcast. It was right around when I started my health journey and started toying with quitting drinking. In this interview, we talk about the moment when Paul realized that the podcast was so much more than an accountability tool—it was a way to help others and, eventually, to grow a business. I invited Paul onto the podcast to share that your passion CAN become a business. As you're listening, I would love to have you listen with the lens of...what's your passion? Have you built a business around it? Because your audience is waiting for it! Tune in! Mentioned in This Episode Café RE: Use the promo code OPPORTUNITY to waive the setup fee Alcohol is SH!T Podcasters Paradise The E-Myth Revisited: Why Most Small Businesses Don't Work and What to Do About It by Michael E. Gerber Johann Hari Ted Talks “Rat Park” Experiment Episode 61: Take Care of Yourself and Your Business with Allison Jordan Client Journey Ebook The Content Mastery Lab About Paul Churchill In 2006, Paul Churchill moved to Granada Spain where he purchased a bar. In the following three years he became dependent on alcohol, blacking out close to 7 nights per week. In 2009, Paul walked away from the bar hoping a geographical cure would curtail the drinking but continued to drink for another 5 years. In February 2015 Paul launched the Recovery Elevator podcast as an accountability tool to stay sober. Today, it's been over 5 years since Paul had his last drink of Alcohol and the podcast has surpassed 5 million downloads, and evolved into a private membership community with over 1,300 members from all over the world. Paul is the author of the best-selling book Alcohol is SH!T, has delivered two TEDx talks, was a featured speaker at My Brave in Los Angeles, and plans to continue eradicating the stigma surrounding alcohol and addiction. Follow Recovery Elevator on Instagram and Facebook.

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The Gary Null Show - 04.28.21

Play Episode Listen Later Apr 28, 2021 59:39

Compound found in some vegetables may reduce diabetes-related kidney damage Phenethyl isothiocyanate, derived from watercress and other cruciferous vegetables, shows benefits Al-Maarefa University (Saudi Arabia), April 27, 2021 New research conducted in rats suggests a compound that gives some cruciferous vegetables their pungent taste could help to reverse kidney problems associated with diabetes. It is estimated that about one-quarter of people with diabetes will eventually develop diabetic nephropathy, a gradual loss of kidney function eventually requiring dialysis. The condition is a leading cause of chronic kidney disease in the U.S. and is also associated with a high risk of heart disease. There is currently no cure. For the new study, researchers assessed the effects of phenethyl isothiocyanate (PEITC) in rats with diabetic nephropathy. PEITC is found in several types of vegetables but is most concentrated in watercress. "Our study provides, for the first time, evidence that PEITC might be effective as a naturally occurring agent to reverse serious kidney damage in people with diabetes," said lead study author Mohamed El-Sherbiny, PhD, a postdoctoral fellow at AlMaarefa University in Riyadh, Saudi Arabia. "Our study introduces mechanistic evidence of how PEITC might manage kidney injury associated with diabetes by targeting multiple interconnected pathways involved in diabetic nephropathy, including inflammation, glycation and oxidative status." El-Sherbiny will present the research at the American Association for Anatomy annual meeting during the Experimental Biology (EB) 2021 meeting, held virtually April 27-30. Previous studies have suggested sulforaphane, a related compound in cruciferous vegetables, also helps reduce diabetes-associated kidney damage. The new study bolsters the evidence that eating more vegetables containing these compounds could help people with diabetes to stave off kidney problems. "PEITC seems to manage one of the most serious and painful diabetic complications. Luckily, PEITC is naturally present in many dietary sources, importantly watercress, broccoli, turnips and radish," said El-Sherbiny. Since the research was conducted in animal models, further studies will be needed to confirm the findings and understand how the results could translate to new treatments or dietary recommendations for people with diabetes. Eating probiotic foods helps improve bone health in women Kyung Hee University (South Korea), April 23, 2021 A recent study by researchers at Kyung Hee University (KHU) in South Korea presents a good example of how powerful probiotics are and how they can be used for medicinal purposes. The researchers examined the effects of probiotics on vaginosis caused by the bacterium, Gardnerella vaginalis, and osteoporosis induced by ovariectomy. They reported that probiotics, specifically, anti-inflammatory bacteria isolated from kimchi, caused significant improvements in female mice with the above-mentioned conditions. The researchers discussed their findings in an in an article published in the Journal of Medicinal Food. Probiotics from fermented food offer substantial benefits for women Bacterial vaginosis (BV) is a type of inflammation caused by the overgrowth of bacterialike G. vaginalis, which naturally reside in the vagina. Normally, good bacteria outnumber bad bacteria and keep them in check; but certain activities, such as frequent douching or unprotected sex, can disrupt the microbial balance in the vagina and promote the growth of bad bacteria. Osteoporosis, also called “porous bone,” is a disease characterized by either the loss of too much bone in the body, a decreased formation of bone, or both. These events cause the bones to become weak and more likely to break from a fall, a minor bump or even from sneezing. According to statistics, osteoporosis is more common in women, with one in three over the age of 50 experiencing bone fractures because of it, while only one in five men experience the same. Genetics and age can play a part in osteoporosis development, along with low calcium intake, thyroid problems, inflammatory conditions and the use of corticosteroid medications. In their study, the team from KHU noted that the excessive expression of tumor necrosis factor-a (TNF-a), a signaling protein (cytokine) secreted by inflammatory cells, is known to aggravate BV and osteoporosis. To determine if probiotics can influence the expression of TNF-a and alleviate these conditions, they isolated anti-inflammatory Lactobacillus plantarum NK3 and Bifidobacterium longum NK49 from kimchi as well as from human fecal samples. They then tested the effects of these good bacteria in female mice with BV and osteoporosis. The researchers reported that oral gavage of NK3 alone or in combination with NK49 significantly alleviated GV-induced vaginosis and decreased GV population in the vagina. The probiotics also inhibited the activation of NF-kB, a transcription factor that increases the production of inflammatory cytokines, and TNF-a expression in the vagina and uterus of the female mice. The researchers also found that treatment with NK3 alone or in combination with NK49 alleviated ovariectomy-induced osteoporosis and obesity. Moreover, it increased blood calcium, phosphorus and osteocalcin levels, as well as suppressed weight gain. NK3 and/or NK49 treatment also reduced TNF-a expression and NF-kB activation in the colon and restored optimal gut microbiota composition. Based on these findings, the researchers concluded that the probiotics present in fermented foods like kimchi can alleviate BV and osteoporosis by reducing inflammation and regulating gut microbial composition. Chronic stress may reduce lifespan in wild baboons, according to new multi-decadal study Duke University, April 21, 2021 Female baboons may not have bills to pay or deadlines to meet, but their lives are extremely challenging. They face food and water scarcity and must be constantly attuned to predators, illnesses and parasites, all while raising infants and maintaining their social status. A new study appearing April 21 in Science Advances shows that female baboons with high life-long levels of glucocorticoids, the hormones involved in the 'fight or flight' response, have a greater risk of dying than those with lower levels. Glucocorticoids are a group of hormones that help prepare the body for a challenge. While these hormones have many functions in the body, persistently high levels of glucocorticoids in the bloodstream can be a marker of stress. To understand the relationship between stress responses and survival, scientists studied 242 female baboons in Amboseli National Park, in Kenya. For more than 20 years, they measured glucocorticoid levels in the baboons' feces, a task that drew upon one of the world's largest collections of data from a wild primate population. Females with higher levels of glucocorticoids in their feces, either due to more frequent exposure to different types of challenges, or more intense stress responses, tended to die younger. The researchers then used these real values of hormone levels and risk of death to simulate a comparison between females that lived at opposite ends of the stress spectrum. The model showed that a hypothetical female whose glucocorticoid levels were kept very elevated would die 5.4 years sooner than a female whose glucocorticoid levels were kept very low. If they reach adulthood, female baboons have an expected lifespan of about 19 years, so 5.4-years represents a 25% shorter life. Five years more life can also represent enough time to raise one or two more infants. The team's simulations represent extreme values that are unlikely to be maintained throughout the females' lives, said Fernando Campos, an assistant professor at the University of Texas San Antonio and lead author of the study. Nonetheless, the link between exposure to stress-associated hormones and survival is clear. "Whether it's due to your environment or your genes or something that we are not measuring, having more glucocorticoids shortens your life," said Susan Alberts, a professor of biology and chair of evolutionary anthropology at Duke and senior author on the paper. The variation in glucocorticoid levels observed by Campos, Alberts, and their team shows that some females have it worse than others. Glucocorticoid levels may vary due to environmental factors, such as growing up in very hot and dry years, social factors, such as living in an unusually small or large group, and individual differences, such as being pregnant more often. "Those are the things we know about," said Alberts, "there's a whole bunch of horrible things that happen to animals that we just can't measure." "Whatever is exposing you to the glucocorticoids is going to shorten your life," Alberts said. "The more hits you get, the worse your outcome." Glucocorticoids play all sorts of vital roles in our bodies. They regulate our immunity, help our bodies access energy from sugars and fats, and modulate metabolic reactions to prepare the body for a challenge. But being constantly prepared for a challenge has high costs: maintenance processes get shut down, and fight or flight processes stay active for longer. Over time, these effects accumulate. "This chronic activation of the stress response leads to a caustic downstream physiological environment of not enough immune system, and not enough attention to maintenance," said Alberts. Associations between stress and survival are extremely difficult to test in a natural scenario. They require very frequent data collection for a very long period of time, in this case through the Amboseli Baboon Research Project, which was launched in 1971. Amboseli females are followed daily from birth to death, their activity is monitored, big events in their lives are recorded, and their feces are periodically collected. "In my lab we have one of the largest collections of primate behavioral data in the world," said Alberts, "and also one of the biggest primate poop collections." More than 14,000 fecal samples were used in this study. Poop is a very valuable, if slightly smelly, repository of information. By measuring hormone levels in feces rather than in blood or saliva, researchers avoid handling and stressing the animals, which could influence hormone levels. "People have long hypothesized that glucocorticoids play a role in how long you live," said Campos, "but to our knowledge this is the first direct evidence that chronic exposure to glucocorticoids strongly predicts survival in wild primates." Smoking cannabis significantly impairs vision, study finds Smoking cannabis significantly impairs vision but many users are unaware of it University of Granada (Spain), April 15, 2021 A study carried out by the University of Granada indicates that smoking cannabis significantly alters key visual functions, such as visual acuity, contrast sensitivity, three-dimensional vision (stereopsis), the ability to focus, and glare sensitivity Yet, more than 90% of users believe that using cannabis has no effect on their vision, or only a slight effect A group of researchers from the Department of Optics of the University of Granada (UGR) has studied the effects of smoking cannabis on various visual parameters compared to the effect that the users themselves perceive the drug to have on their vision. This study, led by Carolina Ortiz Herrera and Rosario González Anera, has been published in the journal Scientific Reports. Its main author, Sonia Ortiz Peregrina, explains that cannabis use is on the rise despite being an illegal drug. According to the national Survey on Alcohol, Drugs and Other Addictions in Spain 2019-2020, cannabis use nationally has increased since 2011, with 37% of Spanish adults having used this drug at some time. Approximately 10% consumed it in the last year. In this study, which had the approval of the Human Research Ethics Committee of the UGR (ref. 921/CCEIH/2019), an exhaustive visual trial was conducted on 31 cannabis users, both when they had not consumed any substance in advance and also when they were under the effect of the drug. The researchers also studied the participants' perception of the visual effects of having consumed this drug. The results showed that, following consumption, visual aspects such as visual acuity, contrast sensitivity, three-dimensional vision (stereopsis), the ability to focus, and glare sensitivity significantly worsened. Despite this, not all subjects reported a worsening of their vision after smoking cannabis. Indeed, 30% reported that their vision had not suffered at all, while 65% responded that it had worsened only slightly. The authors note that the visual parameter that could be most strongly linked to users' perception of the visual effect is contrast sensitivity. The study found a negative effect on all of the visual parameters evaluated, with the effect of cannabis on some of the parameters being analysed for the first time in this research. These results, together with the lack of awareness that the participants presented about the visual impairment caused by smoking cannabis, indicate the need to carry out awareness-raising campaigns, as this visual deterioration can pose a danger when performing everyday tasks. Poor iodine levels in pregnancy poses risks to fetal intellectual development University of South Australia, April 23, 2021 A growing number of young Australian women are at increased risk of having children born with impaired neurological conditions, due to poor iodine intake. Dietary changes, including a growing trend towards the avoidance of bread and iodised salt, as well as a reduced intake of animal products containing iodine can contribute to low iodine levels. A small pilot study undertaken by the University of South Australia (UniSA) comparing iodine levels between 31 vegan/plant-based participants and 26 omnivores has flagged the potential health risk. Urine samples showed iodine readings of 44 ug/L in the plant-based group, compared to the meat eaters' 64 ug/L level. Neither group came close to the World Health Organization's recommended 100 grams per liter. Participants from both groups who chose pink or Himalayan salt instead of iodised salt had severely deficient iodine levels, averaging 23 ug/L. The findings have been published in the International Journal of Environmental Research and Public Health. While the study was undertaken in South Australia, it builds evidence on a 2017 US study (1) that found nearly two billion people worldwide were iodine deficient, resulting in 50 million experiencing clinical side effects. UniSA research dietitian Jane Whitbread says adequate iodine is essential for fetal intellectual development. "Mild to moderate iodine deficiency has been shown to affect language development, memory and mental processing speeds," Ms Whitbread says. "During pregnancy, the need for iodine is increased and a 150mcg supplement is recommended prior to conception and throughout pregnancy. Unfortunately, most women do not take iodine supplements before conceiving. It is important to consume adequate iodine, especially during the reproductive years." Dietary sources of iodine include fortified bread, iodized salt, seafoods including seaweeds, eggs, and dairy foods. Concerns about the link between poor iodine status and impaired neurological conditions in newborns prompted the mandatory fortification of non-organic bread with iodised salt in 2009 in Australia. It has since been reported that women who consume 100g of iodine-fortified bread every day (approximately three pieces) have five times greater chance of meeting their iodine intake compared to women who don't consume that much. The average amount of bread consumed by women in this study was one piece of bread. The growing preference of Himalayan salt over iodized table salt may also be problematic, Ms Whitbread says. A quarter of women in the study reported using the pink salt which contains an insignificant level of iodine. Another issue is that plant-based milks have low levels of iodine and are not currently fortified with this nutrient. Neither group met the estimated average requirement (EAR) for calcium. The vegan/plant-based group also did not reach the recommended levels for selenium and B12 without supplementation, but their dietary intake of iron, magnesium, vitamin C, folate and fibre was higher than the meat eaters. This reflects the inclusion of iron-rich soy products, wholemeal foods, legumes, and green leafy vegetables in their diet. The researchers recommended that both new salts and plant milks be fortified with iodine as well as a campaign to raise awareness about the importance of iodine in the diet, especially for women in their reproductive years. They also called for a larger study sample to determine iodine status of Australian women. Taking vitamin D could lower heart disease risk for people with dark skin Racial disparities in heart disease may be linked to vitamin D deficiency Penn State University, April 26, 2021 New research suggests a simple step could help millions of people reduce their risk of heart disease: make sure to get enough vitamin D. Elucidating linkages between skin pigmentation, vitamin D and indicators of cardiovascular health, the new study, combined with evidence from previous research, suggests vitamin D deficiency could contribute to the high rate of heart disease among African Americans. "More darkly-pigmented individuals may be at greater risk of vitamin D deficiency, particularly in areas of relatively low sun exposure or high seasonality of sun exposure," said S. Tony Wolf, PhD, a postdoctoral fellow at the Pennsylvania State University and the study's lead author. "These findings may help to explain some of the differences that we see in the risk for developing blood vessel dysfunction, hypertension and overt cardiovascular disease between ethnic groups in the United States. Although there are many factors that contribute to the development of hypertension and cardiovascular disease, vitamin D supplementation may provide a simple and cost-effective strategy to reduce those disparities." Wolf noted that the need for vitamin D supplementation depends on a variety of factors, including where you live, how much time you spend in the sun, your skin pigmentation and your age. Wolf will present the research at the American Physiological Society annual meeting during the Experimental Biology (EB) 2021 meeting, held virtually April 27-30. Melanin, which is more concentrated in darker skin, is known to inhibit the process our bodies use to make vitamin D in the presence of sunlight. As a result, darkly pigmented people may make less vitamin D, potentially leading to vitamin D deficiency. For the study, Wolf and colleagues measured skin pigmentation, vitamin D and the activity of nitric oxide in the small blood vessels beneath the skin in 18 heathy adults of varying skin tones. Nitric oxide is important for blood vessel function, and reduced nitric oxide availability is thought to predispose an individual to the development of hypertension or cardiovascular disease. Previous studies suggest vitamin D helps to promote nitric oxide availability. Study participants with darker skin had lower levels of vitamin D and lower nitric oxide availability. In addition, the researchers found that lower levels of vitamin D were related to reduced nitric oxide-mediated blood vessel function. The results align with those of a separate study by the same research group, which found that vitamin D supplementation improved blood vitamin D levels and nitric oxide-mediated blood vessel function in otherwise healthy, young African American adults. "Vitamin D supplementation is a simple and safe strategy to ensure vitamin D sufficiency," said Wolf. "Our findings suggest that promoting adequate vitamin D status in young, otherwise healthy adults may improve nitric oxide availability and blood vessel function, and thereby serve as a prophylactic to reduce risk of future development of hypertension or cardiovascular disease." Men's loneliness linked to an increased risk of cancer University of Eastern Finland, April 27, 2021 A recent study by the University of Eastern Finland shows that loneliness among middle-aged men is associated with an increased risk of cancer. According to the researchers, taking account of loneliness and social relationships should thus be an important part of comprehensive health care and disease prevention. The findings were published in Psychiatry Research. "It has been estimated, on the basis of studies carried out in recent years, that loneliness could be as significant a health risk as smoking or overweight. Our findings support the idea that attention should be paid to this issue," Project Researcher Siiri-Liisi Kraav from the University of Eastern Finland says. The study was launched in the 1980s with 2,570 middle-aged men from eastern Finland participating. Their health and mortality have been monitored on the basis of register data up until present days. During the follow-up, 649 men, i.e. 25% of the participants, developed cancer, and 283 men (11%) died of cancer. Loneliness increased the risk of cancer by about ten per cent. This association with the risk of cancer was observed regardless of age, socio-economic status, lifestyle, sleep quality, depression symptoms, body mass index, heart disease and their risk factors. In addition, cancer mortality was higher in cancer patients who were unmarried, widowed or divorced at baseline. "Awareness of the health effects of loneliness is constantly increasing. Therefore, it is important to examine, in more detail, the mechanisms by which loneliness causes adverse health effects. This information would enable us to better alleviate loneliness and the harm caused by it, as well as to find optimal ways to target preventive measures." How exercise and the simple act of moving your body can improve mental health University of Toronto, April 26, 2021 Whether running around a track or simply stretching in your living room, physical activity can go a long way toward making you happier. Catherine Sabiston, a professor in the University of Toronto's Faculty of Kinesiology & Physical Education, says the positive impact of exercise on mental health is well-documented. "There is uncontested evidence that physical activity is conducive to mental health," she says. For example, Sabiston co-authored a study in the Journal of Sport and Exercise Psychology that adolescents who consistently participated in team sports during high school reported lower depression levels in early adulthood. A Canada Research Chair in physical activity and mental health, Sabiston directs a lab that studies the connections between physical activity and mental health, developing and evaluating interventions to promote physical activity and mental wellness among people who are at risk of inactivity and mental health problems. The lab also runs a six-week program called MoveU.HappyU that provides customized coaching and training aimed at reducing the stress and anxiety of students in the lab through physical movement. She recently spoke with U of T News about why it's important to stay active during the pandemic—and how to feel good doing it. How closely connected are physical activity and mental health? Symptoms of mental illness such as anxiety and depression can impede physical activity and vice versa. When you are experiencing symptoms, you may also encounter feelings of low self-worth and an inability to be motivated. It's very hard to find a type of physical activity that you can engage in when you lack interest in most things. Many of the symptoms tied to mental illness are also barriers to physical activity. On the flip side, there is uncontested evidence that physical activity is conducive to mental health. Physical activity prevents some forms of mental illness, and, for individuals who have been diagnosed with mental illness, physical activity can help reduce those symptoms and improve their quality of life. It holds its own weight in comparison to all other forms of treatment for mental illness, including psychotherapy and even medication. Physical activity is a potential adjunct to any other form of preventative or treatment-focused therapy. How exactly does exercise lift our mood? There are a number of mechanisms at play, including physical activity effects that are tied to our brain activity and brain chemistry. Physical activity increases our body temperature. When we are warmer, we are given the sense that we are comfortable and cared for. Also, from a historical perspective, we know that humans were naturally much more active in the past than we are now. So, physical activity brings us closer to that core level of movement that human bodies are meant to be. Moreover, physical activity can mimic mental health symptoms such as anxiety. When you exercise, you may sweat or feel your heart racing. That mimics the feeling of panic, so by engaging in exercise, you are producing a similar physical effect that can make you more accustomed to those symptoms. Exercise also provides you with an opportunity, whether for two minutes or 20, to break away from your usual routines or worries. This escape can help people better cope with their symptoms while experiencing a sense of purpose or accomplishment. In fact, feelings of mastery and accomplishment are also specific ways that physical activity impacts mental health. Small goals and activities inherent to physical activity offer plenty of opportunities for positive feedback, feeling successful and achieving, which helps stave off symptoms of mental illness. Finally, physical activity is something you can partake in outdoors, which has a potentiating effect on mental health. That allows you to see other people, even if you are not interacting with them, and feel a sense of connectedness. What are some ways people can stay active and motivated during the pandemic? We want to dispel the myth that physical activity is just running, biking and lifting weights. Physical activity can be any movement where your heart is increasing its work capacity and your body is moving. In "MoveU.HappyU," we coach students on day-to-day strategies for how to maintain a level of physical activity. Because the program is virtual now, we have trained students who are currently all over the world. Some students who had never spoken to their families about their mental health struggles are now actually having their whole families join in on the physical activities. The physical activity you are doing should be something that you enjoy. If you don't enjoy it, you're not going to continue to do it. We also want people to engage in physical activity to improve function rather than appearance. It's important to uncouple the relationship between physical activity for weight and body-size reasons and move towards physical activity for enjoyment and fun reasons. If it's fun, you are more likely to do it, and more likely to do it leads to more benefits. Do you have any tips for people looking to boost physical activity at home? There are many ways you can innovate physical activity to make it more varied, even when you are stuck in the same place. The best part of physical activity is thinking about the endless possibilities of ways your body can move. If you are purposeful about it, physical activity can be integrated into your everyday routines: Set aside time as you would if you were going to the gym or commuting. Mark it in your calendar or set an alarm to give you an actual reminder. Use your phone or a pedometer to measure your step count. Having something that measures how many steps you're taking gives you a baseline: If you know you walked a certain number of steps on day one, you can add five additional steps on day two. That way you'll have a tangible goal for increasing movement. Consciously link items or places in your home to short bouts of movement. For example, if you use the toaster oven every morning, make a habit of doing squats while you're waiting for your bread. Or when you are wheeling from one room to another, add some extra distance. When you're outside, use aspects of your environment to change up your physical activity. You can change the intensity of your walking or wheeling, for instance, each time that you pass a lamppost or see a blue car. Make it fun to change up the intensity, type, and timing of your activities. Create movement challenges for yourself and your friends, family, colleagues, or students. Set goals for taking a certain number of steps or finishing a certain number of arm raises each day. Making physical activity more like a game is a proven strategy for increasing movement—and enjoying it.

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Wildly different paths to Granada, Spain with Claudia Neiman & Dani Norwell

Adventure Calls

Play Episode Listen Later Mar 16, 2021 36:42

Immerse yourself in Granada, Spain before listening in on the conversation with the two co-founders of Sincerely, Spain. Claudia Neiman and Dani Norwell. In today's conversation, we talk about life in Spain, and we get real about the challenges of expat life.What drew today's two guests here is wildly different, although they're both from the US Midwest. Claudia Neiman and Dani Norwall are the Founders of Sincerely, Spain, a website where they share their experiences and insights on topics related to living abroad, language learning and culture in Spain. Dani called in from Granada, Spain, where she is based, while Claudia called from Finland, where she recently relocated after several years in Spain. Find Sincerely Spain On SincerelySpain.comOn InstagramOn YouTubeOn FacebookOn PinterestFind Dani Norwell, Author On InstagramDani's book Fairly Familiar Find Jess DruckerOn InstagramOn TwitterOn FacebookExpat Life CoachingHow To Move Abroad BookAdventure Calls PodcastAbout Adventure Calls Adventure Calls is produced, edited and written by me, Jess Drucker, a four-time expat, world-traveler and author of How To Move Abroad And Why It's The Best Thing You'll Do. Essentially a masterclass in book form, the book (available on Amazon in paperback and ebook) distills my 15 years' experience living abroad into 300 pages of practical step-by-step advice and inspiration for anyone looking to follow their own call to adventure. If you enjoy the show, please rate and review on Apple podcasts, or wherever you listen to podcasts!

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The Gary Null Show - 02.19.21

Music & Life, by Abdallah Harati

Play Episode Listen Later Feb 19, 2021 53:03

Gary takes on the real issues that the mainstream media is afraid to tackle. Tune in to find out the latest about health news, healing, politics, and the economy. Gut microbiome implicated in healthy aging and longevity Data from over 9,000 people reveal a distinct gut microbiome signature that is associated with healthy aging and survival in the latest decades of life Institute for Systems Biology (Seattle), February 18, 2021 The gut microbiome is an integral component of the body, but its importance in the human aging process is unclear. ISB researchers and their collaborators have identified distinct signatures in the gut microbiome that are associated with either healthy or unhealthy aging trajectories, which in turn predict survival in a population of older individuals. The work is set to be published in the journal Nature Metabolism. The research team analyzed gut microbiome, phenotypic and clinical data from over 9,000 people - between the ages of 18 and 101 years old - across three independent cohorts. The team focused, in particular, on longitudinal data from a cohort of over 900 community-dwelling older individuals (78-98 years old), allowing them to track health and survival outcomes. The data showed that gut microbiomes became increasingly unique (i.e. increasingly divergent from others) as individuals aged, starting in mid-to-late adulthood, which corresponded with a steady decline in the abundance of core bacterial genera (e.g. Bacteroides) that tend to be shared across humans. Strikingly, while microbiomes became increasingly unique to each individual in healthy aging, the metabolic functions the microbiomes were carrying out shared common traits. This gut uniqueness signature was highly correlated with several microbially-derived metabolites in blood plasma, including one - tryptophan-derived indole - that has previously been shown to extend lifespan in mice. Blood levels of another metabolite - phenylacetylglutamine - showed the strongest association with uniqueness, and prior work has shown that this metabolite is indeed highly elevated in the blood of centenarians. "This uniqueness signature can predict patient survival in the latest decades of life," said ISB Research Scientist Dr. Tomasz Wilmanski, who led the study. Healthy individuals around 80 years of age showed continued microbial drift toward a unique compositional state, but this drift was absent in less healthy individuals. "Interestingly, this uniqueness pattern appears to start in mid-life - 40-50 years old - and is associated with a clear blood metabolomic signature, suggesting that these microbiome changes may not simply be diagnostic of healthy aging, but that they may also contribute directly to health as we age," Wilmanski said. For example, indoles are known to reduce inflammation in the gut, and chronic inflammation is thought to be a major driver in the progression of aging-related morbidities. "Prior results in microbiome-aging research appear inconsistent, with some reports showing a decline in core gut genera in centenarian populations, while others show relative stability of the microbiome up until the onset of aging-related declines in health," said microbiome specialist Dr. Sean Gibbons, co-corresponding author of the paper. "Our work, which is the first to incorporate a detailed analysis of health and survival, may resolve these inconsistencies. Specifically, we show two distinct aging trajectories: 1) a decline in core microbes and an accompanying rise in uniqueness in healthier individuals, consistent with prior results in community-dwelling centenarians, and 2) the maintenance of core microbes in less healthy individuals." This analysis highlights the fact that the adult gut microbiome continues to develop with advanced age in healthy individuals, but not in unhealthy ones, and that microbiome compositions associated with health in early-to-mid adulthood may not be compatible with health in late adulthood. "This is exciting work that we think will have major clinical implications for monitoring and modifying gut microbiome health throughout a person's life," said ISB Professor Dr. Nathan Price, co-corresponding author of the paper. Rosmarinic acid suppresses cognitive decline in Alzheimer disease mouse model University of Tokyo (Japan), February 15, 2021 According to news originating from the University of Tokyo , research stated, “Rosmarinic acid (RA), a polyphenol found in Lamiaceae herbs, is a candidate of preventive ingredients against Alzheimer’s disease (AD) as it potently suppresses the aggregation of amyloid b (Ab); however, the effect of RA on tau phosphorylation and cognitive dysfunction remains unclear.” Financial supporters for this research include Japan Society for the Promotion of Science; Japan Agency for Medical Research and Development; Cross-Ministerial Strategic Innovation Promotion Program. The news editors obtained a quote from the research from University of Tokyo: “The present study revealed that RA intake inhibited the pathological hallmarks of AD, including Ab and phosphorylated tau accumulation, and improved cognitive function in the 3 x Tg-AD mouse model. Additionally, RA intake suppressed hippocampal inflammation and led to the downregulation of the JNK signaling pathway that induces tau phosphorylation. Feeding with RA exerted an anti-inflammatory effect not only in the central nervous system but also in the periphery.” According to the news editors, the research concluded: “Downregulation of the JNK signaling pathway in hippocampus may be a potential mechanism underlying the inhibition of progression of pathology and cognitive deficit by RA feeding.” Excess fatty tissue accumulated in the neck increases the chances of suffering heart problems, according to a new study University of Granada (Spain), February 15, 2021 Researchers from the University of Granada warn that an accumulation of fatty tissue in the neck (both the double chin and the deeper deposits, located between muscles and around the cervical vertebrae) is a predictor of central and overall adiposity, cardiometabolic risk, and a pro-inflammatory profile in sedentary young adults. Traditionally, the accumulation of visceral adipose tissue has been considered one of the factors most strongly related to cardiometabolic risk and chronic (low-grade) inflammation in humans. However, this well-established association has led researchers to neglect, to some degree, the study of other fatty deposits and their clinical/biological relevance. "Curiously, several studies have demonstrated that the accumulation of fat in the neck (both superficial deposits such as the double chin or jowls and the deeper deposits, located between the muscles and around the cervical vertebrae) increases in direct proportion to the weight or adiposity of the individual and that it follows specific accumulation patterns, according to gender," explains María José Arias Téllez, a researcher at the UGR and one of the main authors of this work. In fact, a greater accumulation of fat in certain neck tissue compartments, particularly the deeper ones, is linked to a greater likelihood of cardiometabolic risk. Arias Téllez says, "However, the evidence accumulated to date has been based on experiments performed on patients with benign/malignant tumors or other chronic conditions, and it remains to be seen whether it can be generalized to relatively healthy adults." The study carried out at the UGR is part of the ACTIBATE project (Activating Brown Adipose Tissue through Exercise—seeprofith.ugr.es/actibate). The research was led by Jonatan Ruiz Ruiz and its results have been published in the International Journal of Obesity. The study shows that the accumulation of fat in the neck—measured with computed tomography scanning—as well as its distribution in different compartments, is associated with greater overall and central adiposity, greater cardiometabolic risk, and a greater inflammatory status among healthy young adults, regardless of the amount of total and visceral fat. In addition, among the most relevant findings, the researchers observed that this accumulation of fat in the neck was as powerful a factor (in terms of direction and magnitude) as the accumulation of visceral fat in the prediction of cardiometabolic risk and inflammatory status, especially in men. "Therefore, these results underline the need for further research in this new direction, to better understand the effect of fat accumulation in the upper part of the trunk (including the neck) and its clinical repercussions, especially in cardiometabolic riskand inflammation," explains Francisco Miguel Acosta Manzano, one of the main authors of the research. "We still have much work to do. We need to investigate the adipose tissue of the neck in greater depth, to understand its pathogenic role in obesity and associated comorbidities, as well as its biological importance. Furthermore, we only have scant knowledge about the morphological or molecular characteristics of the adipocytes in these deposits, and here basic studies are required. As we increase our knowledge of this deposit, we can also determine whether specific interventions (for example, physical exercise and/or restricted calorie intake) could help reduce the accumulation of fat in the neck (as well as total fat) and implement them clinically," explain Arias Téllez and Francisco Miguel Acosta Manzano, both Ph.D.s students on the Biomedicine program of the UGR's International School for Postgraduate Studies Effects of saffron extract supplementation on mood, well-being and response to a psychosocial stressor in healthy adults Northumbria University (UK), February 16, 2021 According to news reporting originating from Newcastle upon Tyne, United Kingdom, research stated, “Anxiety, stress, and low mood are closely related and may contribute to depressive symptoms. Among non-pharmacological solutions to improve subclinical mood symptoms and resilience to stress, natural products such as saffron-identified as promising following preliminary beneficial effects in major depressive disorder-represent a relevant strategy.” Our news reporters obtained a quote from the research from Northumbria University: “This study aimed to assess the efficacy of 8 weeks’ supplementation with 30 mg standardized saffron extract on emotional well-being in healthy adults with subclinical feelings of low mood and anxiety and/or stress and evaluate the acute effect of saffron in response to a lab-based psychosocial stressor. The study adopted a double-blind, randomized, parallel groups design in which 56 healthy male and female individuals (18-54 years) received either a saffron extract or a placebo for 8 weeks. Chronic effects of saffron on subjective anxiety, stress, and depressive feelings were assessed using a questionnaire battery [including Profile of Mood State-2, (POMS)] and acute effects in response to a lab-based psychosocial stressor were measured through psychological and physiological parameters. Urinary crocetin levels were quantified. Participants who received the saffron extract reported reduced depression scores and improved social relationships at the end of the study. Urinary crocetin levels increased significantly with saffron supplementation and were correlated with change in depression scores. The typical stress-induced decrease in heart rate variability (HRV) during exposure to the stressor was attenuated following acute saffron intake.” According to the news editors, the research concluded: “Saffron extract appears to improve subclinical depressive symptoms in healthy individuals and may contribute to increased resilience against the development of stress-related psychiatric disorders. Clinical trials number: NCT03639831.” The science of siestas: New research reveals the genetic basis for daytime napping Massachusetts General Hospital and University of Murcia (Spain), February 13, 2021 How often a person takes daytime naps, if at all, is partly regulated by their genes, according to new research led by investigators at Massachusetts General Hospital (MGH) and published in Nature Communications. In this study, the largest of its kind ever conducted, the MGH team collaborated with colleagues at the University of Murcia in Spain and several other institutions to identify dozens of gene regions that govern the tendency to take naps during the day. They also uncovered preliminary evidence linking napping habits to cardiometabolic health Napping is somewhat controversial,” says Hassan Saeed Dashti, Ph.D., RD, of the MGH Center for Genomic Medicine, co-lead author of the report with Iyas Daghlas, a medical student at Harvard Medical School (HMS). Dashti notes that some countries where daytime naps have long been part of the culture (such as Spain) now discourage the habit. Meanwhile, some companies in the United States now promote napping as a way to boost productivity. “It was important to try to disentangle the biological pathways that contribute to why we nap,” says Dashti. Previously, co-senior author Richa Saxena, Ph.D., principal investigator at the Saxena Lab at MGH, and her colleagues used massive databases of genetic and lifestyle information to study other aspects of sleep. Notably, the team has identified genes associated with sleep duration, insomnia, and the tendency to be an early riser or “night owl.” To gain a better understanding of the genetics of napping, Saxena’s team and co-senior author Marta Garaulet, Ph.D., of the Department of Physiology at the University of Murcia, performed a genome-wide association study (GWAS), which involves rapid scanning of complete sets of DNA, or genomes, of a large number of people. The goal of a GWAS is to identify genetic variations that are associated with a specific disease or, in this case, habit. For this study, the MGH researchers and their colleagues used data from the UK Biobank, which includes genetic information from 452,633 people. All participants were asked whether they nap during the day “never/rarely,” “sometimes” or “usually.” The GWAS identified 123 regions in the human genome that are associated with daytime napping. A subset of participants wore activity monitors called accelerometers, which provide data about daytime sedentary behavior, which can be an indicator of napping. This objective data indicated that the self-reports about napping were accurate. “That gave an extra layer of confidence that what we found is real and not an artifact,” says Dashti. Several other features of the study bolster its results. For example, the researchers independently replicated their findings in an analysis of the genomes of 541,333 people collected by 23andMe, the consumer genetic-testing company. Also, a significant number of the genes near or at regions identified by the GWAS are already known to play a role in sleep. One example is KSR2, a gene that the MGH team and collaborators had previously found plays a role in sleep regulation. Digging deeper into the data, the team identified at least three potential mechanisms that promote napping: Sleep propensity: Some people need more shut-eye than others. Disrupted sleep: A daytime nap can help make up for poor quality slumber the night before. Early morning awakening: People who rise early may “catch up” on sleep with a nap. “This tells us that daytime napping is biologically driven and not just an environmental or behavioral choice,” says Dashti. Some of these subtypes were linked to cardiometabolic health concerns, such as large waist circumference and elevated blood pressure, though more research on those associations is needed. “Future work may help to develop personalized recommendations for siesta,” says Garaulet. Furthermore, several gene variants linked to napping were already associated with signaling by a neuropeptide called orexin, which plays a role in wakefulness. “This pathway is known to be involved in rare sleep disorders like narcolepsy, but our findings show that smaller perturbations in the pathway can explain why some people nap more than others,” says Daghlas. One or more soda a day could decrease chances of getting pregnant Boston University School of Public Health, February 13, 2021 The amount of added sugar in the American diet has increased dramatically over the last 50 years. Much of that increase comes from higher intake of sugar-sweetened beverages, which constitute approximately one-third of the total added sugar consumption in the American diet. While consumption of these beverages has been linked to weight gain, type 2diabetes, early menstruation, and poor semen quality, few studies have directly investigated the relationship between sugary drinks and fertility. Now, a new study led by Boston University School of Public Health (BUSPH) researchers has found that the intake of one or more sugar-sweetened beverages per day—by either partner—is associated with a decreased chance of getting pregnant. The study was published in Epidemiology. "We found positive associations between intake of sugar-sweetened beverages and lower fertility, which were consistent after controlling for many other factors, including obesity, caffeine intake, alcohol, smoking, and overall diet quality," says lead author Elizabeth Hatch, professor of epidemiology. "Couples planning a pregnancy might consider limiting their consumption of these beverages, especially because they are also related to other adverse health effects." About 15 percent of couples in North America experience infertility. Identifying modifiable risk factors for infertility, including diet, could help couples conceive more quickly and reduce the psychological stress and financial hardship related to fertility treatments, which are associated with more than $5 billion in annual US healthcare costs. Through the Pregnancy Study Online (PRESTO), an ongoing web-based prospective cohort study of North American couples, the researchers surveyed 3,828 women aged 21 to 45 living in the United States or Canada and 1,045 of their male partners. Participants completed a comprehensive baseline survey on medical history, lifestyle factors, and diet, including their intake of sugar-sweetened beverages. Female participants then completed a follow-up questionnaire every two months for up to 12 months or until pregnancy occurred. Both female and male intake of sugar-sweetened beverages was associated with 20 percent reduced fecundability, the average monthly probability of conception. Females who consumed at least one soda per day had 25 percent lower fecundability; male consumption was associated with 33 percent lower fecundability. Intake of energy drinks was related to even larger reductions in fertility, although the results were based on small numbers of consumers. Little association was found between intake of fruit juices or diet sodas and fertility. "Given the high levels of sugar-sweetened beverages consumed by reproductive-aged couples in North America, these findings could have important public healthimplications," the authors concluded.

Silvia Molino - Polyphenol Expert

Gut Check Project

Play Episode Listen Later Feb 11, 2021 67:46

Bienvenidos Ah, this is where no, sorry, I screwed it up. So I got really nervous. It's like the lights came on. Okay.Remember, we're actually saying that Yeah.Okay, there we go. Three. You ready? Oh, yeah. Okay. Three, two on bmnh Oh, god check project. Your soy, Eric. Esta Dr. Brown,Dr. Brown Como estas Morgana, grassy asmita story super emotional o por el podcastone tenemos en invitado fantastical. gephi ancestors that podcast story.Sylvia done this style of video.Wait, wait, wait, wait, wait, guys, I can't speak English. Oh, okay.Oh, thank goodness cuz I'm pretty sure that's all the Spanish Eric knew. And banyo I got that down too. So why don't we Why don't we start over and just take it from the top in English. Now that we know that our wonderful guest who lives in Spain to learn all about That's right. actually speaks English. Okay, probably should have figured that out. Before we started the podcastguys. I'm gonna start all over. So welcome gut check project fans and KB MD health family. It's now episode number 49. I'm Eric. This is my awesome co host Dr. Kenneth Brown. And today we've got an incredible special guest that I tried. I you know, I can't I tried Spanish.I tried. You did so Eric. Eric dusted off his eighth grade Spanish. He was trying to impress Silvia you know, I mean, we're both a little nervous because what what we have on the podcast today is super special. Everybody has heroes in their life and Silvia is my hero because she is a poly phenol expert. She's getting her doctorate in specifically the polyphenols that we use on Tron teal. So she knows more about it than anybody I've ever met. And I'm so excited and nervous that we actually tried to speak in her native her native language.I'm just embarrassed that but there'll be a welcome to the show. Welcome to go check project. Thank you so much for makingvideos.She said y'all she's trying tolearn some Texas now first of all, Silvia get us up to speed you're living in Granada Spain. What is going on there? You You WhatsApp to me You guys got a little earthquake situation right?Yeah, we were we were we were that weights. But now where? We stay better here. Fortunately, visitation is is better.You said it so calm. When you just WhatsApp you're like, oh, things are good. Here. We're dealing with a lot of earthquakes. Thanks for asking. Tough in Spain.We used to.So this is this is super cool. Thank you so much for coming on the podcast. I have followed your work. Some of the work that you have done as the lead author I have used we've discussed it on multiple podcasts. If you've seen Episode 47 Episode 46 multiple other episodes, we always refer to the large stable polyphenols and how they get broken down by the microbiome and the purse that articles that always reference. This is the author of those articles. Sylvia Molino, who is I almost called you doctor but you're almost a doctor, right? almost almost.Nice. Nice. Hey, sowhy don't you tell us a bit about your background how you ended up there? What's going on? Everything Everything about Silvia Molino.Okay, so I am a biologist. I got my master's degree in Italy. But I the my train sheep here in Granada, where we started working with embitter. And they're just in implementation. And I fell in love with this argument. And then in one Congress, I met Michaela Battaglia is the CEO of silica team, that Britain is a b2b company that produced what the word leader is producing tannins that are polyphenols, sure, and he got interested in my work. So we started collaborating and and then we had the idea to create a new project to investigate the application of tannins in humans. And so I just started with my PhD working on that, and I'm still working on that and we have continuing on thatYeah, that's awesome. So when you when you first hopped into it, were polyphenol something that drew your interest in their immediate applications for for health or is it something that just kind of just happened over time? What was it that drew you into wanting to study about polyphenols?Well, um, I ever I always have been interesting in polyphenols about more in general about nutraceutical okay, because I believe that we could treat some diseases or some dysfunction with natural product, because actually, we are using a lot of synthetic treatment, but they were discovered from studying nature. So sometimes I think that we could go back to the power of nature. And in this case, 10 isabsolutely Well honestly, the timing really couldn't be better and where we find ourselves not just in the United States, but obviously all the way around the world for us to find and escape from synthetic solutions to what otherwise are just natural problems. And if probably we were consuming more polythene hauls as a you know, for the entire earth we would be in better shape. Yeah.Repeat that.Eric was just saying that you're exactly right. We have always we have a we have felt that the consumption of polyphenols is what what we're lacking in the western American diet. If we had more polyphenols we would have better health.Yeah, yeah, for sure. Yeah,I was just gonna say you use the word nutraceutical, which is, which is interesting because we've, we've coined that term, but what does nutraceutical mean to you as a scientist?Wow, it's a hard question for me and you're just starting over is a solution that could be assumed for from a person by person. Like it will be a part of the natural diet like it will be a tude. Okay, so something more natural.Okay, so a functional food, nutraceutical interesting, a molecule that can have health benefits, but it's found in nature?Yeah, exactly.And so you through your research, you found that these beautiful molecules called polyphenols have hold all this potential to be bioactive and possibly a nutraceutical for humans. So, for anybody that has not heard this, can you explain in your words what a poly phenol is?Well, polyphenols are molecules if we can find in a network, obviously, the name derives from the chemical structure and they are well known for the multiple by activities beneficial by activities. First of all, they are antioxidant, they are what non antioxidant. And this is a super important characteristic of them because they help us to counteract the action of the oxidative stress. The oxidative stress is a normal events that we have that happens in our bodies, and can lead to a lot a lot of diseases and a lot of problems.So leading to like inflammation, is that kind of what you're talking about there with long exposures of oxidative stress?Well, can you repeat, please?Sure. Are you saying that oxidative stress leads to inflammation, like more inflammation around tissues? Is that what you're saying?Yeah, for sure. Well, normally we our normal metabolism, I produce free radicals. Okay. And this normal normal process of power rally, but what happens if we produce a high amount of, of these free radicals, and it's normal to breathe in sometimes to produce a lot of free radicals. And the causes could be external factors, such as stress or bad diet, for example, we have some endogenous mechanisms of our body to counteract these production of oxidative stress done by the free radicals, but these are not sufficient and are not not the most of the times. So we need to intake somehow. From from external hub. And in this case, we have to take antioxidant. And antioxidant we can find, for example, polyphenols, other one on the oxygen, for example, our could be vitamin C, Vitamin E. But from our study, for example, we could discover that time knees, among other 43 years has exert a higher activity than this well known molecules, such as vitamin C. So we could, in this case, it is a smaller amount of external external compounds and not enough to not have to have the same effect. So it's so great.Okay, now it makes it makes a lot of sense. Very congruent.Yeah, it absolutely does. So when we talk about these polyphenols and you brought up tannins, which is what your research has been in, we know that people that are discussing polyphenols, the molecules that make vegetables colorful, there are different sizes and different characteristics as a researcher that you have figured out, can you explain the differences in sizes, characteristics and antioxidant capabilities? Just real grossly and then we'll talk about some of your research because I think it's so cool. Getting the foundation like this.Yeah, I'm on point he knows Wait, what polyphenols are a huge group of molecules. Among them we can find tannins and tannins are one known for the characteristic to the capacity to bind and precipitate protein alkaloids and carbohydrates among other molecules. Among tannins, we can have hydrolyzable tannins and condensed hominids, the realizable Chinese are called like that because they are the they are either realizable, with a lot of facility with weak weak assets. Among these group, we could find Gulf tannins, and a lot of tannins, depending on the different structure nucleus that we can find in the in the in the compounds. And when we don't have a generalizable tannins we have so condensed tannins destructors are characterized by the presence of Brandis entities that can form a big big structure like with with bending blocks. Just explain in an easier way. And sometimes we could have also an association between advisable timings and condensed tannins. And so we have complex diamonds and the name was explained the complexity of the molecules because they we have in this case, big big big molecules.Sothe these molecules that are larger Danny's the alternates, and the contents on this are characterized by the presence of a lot of hydroxyl groups. And these groups are responsible of the antioxidant, the great antioxidant capacity of the planets. So it's also so important.So let me pause you right there. So you're saying that the what makes these polyphenols unique the polyphenols under the big umbrella, or the large polyphenols proanthocyanidins which are in the class of tannins. They have tremendous antioxidant capacity because they have the hydroxyl groups, a bunch of them all around the hydroxyl group is the oh ah that you'll see in those chemistry structures are always there, hydroxyl. So you're saying that the the amount of hydroxyl groups is very important to the antioxidant component?Yeah, definitely. And they can exert they are different activity in different way. For example, and thanks to the hydroxyl groups, they could they have the capacity to come in the free radicals. But in other cases they could have, they could have also our endogenous antioxidant system, for example, they can use the production of antioxidant enzymes that we can produce.Like, is that like super oxide? dismutase? Is that one of them? The anti turning onto what is it? What is an example of a endogenous antioxidant enzyme that the tenant turns on?Well, well, what I was saying before what what I was what I was explaining before About our endogenous response to the oxidative stress, we produce some antioxidant enzymes, okay, for example supersedure, dismutase, or catalase, okay? So we know that tannins among all therefore the females can in us increase the production of these enzymes, so reducing that oxidative stress in our body.So it's twofold. It can basically bind to these weak acids, as well as make our bodies produce more of the enzymes to help basically combine these free radicals.Onto production. Yeah,that's awesome. And I think that once we get to your studies, we're gonna find it. That's not that's just the tip of the iceberg. That'sjust tip of the iceberg. So everybody, so over here, Sylvia, there's shows like Dr. Oz, or he's always talking about different diets, and they're always talking about different compounds. They rarely discuss it as a polyphenol, but they'll have a show on green tea extract egcg, or they'll have a show on reservatrol. Or they'll do these different things. But these are all polyphenols. But what people don't understand is this complex science that you're an expert in, which is what I love, because I can sit with my patients, and explain to them why these these particular polyphenols whether in diet, we always ask everybody during their diet or through a supplement, do multiple things. And the tip of the iceberg is the potent antioxidant.Yeah, totally. Because the the oxidative startles then could lead to multiple diseases, that will be chronic diseases or chronic inflammation. So in this case, we can counteract a lot of problems. Systemic levels, or at local level.Now, the research when you when you teamed up with Michaela, had you been doing research on these polyphenols? Or did you take some of the research that Silva team had done with the animal studies? Because they've been involved with cattle in the wine industry for so many years? Was this? Was this a hard step to move from some of that research over to the data that we're going to talk about with your different studies?Well, they have a great experience with with animals, they were they are working with animals from 15 years, maybe more or less. But it's true. Try to start working with with humans is always different, because the information that we have in animals could have, but it's not a reality is not atranslate, just because it happens in an animal doesn't mean it will happen in a human.It's true. I wanted to say that. Okay, thank you. So, we're here, I started working with an in vitro system, just to study in the deep in the, in this Moore's more particles, because I wanted to know, how these molecules are acting and how they are metabolized. Because there are a lot of literature about tannins, but there, there still be big lack about the information because it's totally new this argument, this issue. So I first started working on the antioxidant activity of different extract. And then I proceeded to digest and ferment in vitro, just simulating that the digestion of the human body to try to drain to discover what's happening in our body when we intake tannins,so I'm sorry, no, no. Well, how long have you been then working with Mikayla and Sylvia team then because what I'm curious about is since you started doing your research, and kind of what your observation is, or how you've seen the world's view possibly change or be influenced by powerful studies regarding polyphenols and their benefits with health what what have you seen while you've been working with Michaela, and has the has the are people more receptive to that idea?Well, I started a six years ago, okay. And when I started, I have to be clear, I didn't know anything about tunings. I knew just the tunings about wine, wine, I'm Italian It was a total discover for me. Um, yeah. From my studies, I think that we discover a new product that could resolve a lot of problem. Above all, I think this is a great way discovered about InDesign. It is, I think the solution for all the problem, I don't know, maybe could be strange to understand. But I discovered a lot a lot of properties of time knees, because fundamentally, they have a prebiotic action. So they function like a fiber, they help our digestion, they can modulate the composition of our microbiota, and through that they can regulate our inflammatory status, our oxidative status, so it's perfect.I think that's so incredible, because what we always hear about is just the antioxidant potential. So here from a marketing standpoint, a lot of people try and sell supplements, they go, this is an antioxidant, this has the highest antioxidant capacity. What you have discovered in your research is, these beautiful large molecules do so much more than that, which you just touched on right there, which is it functions like a prebiotic, meaning that it feeds our own microbiome. And we know that when we have a diverse microbiome, you end up having a healthier body all around. So when I started treating my patients with our combination of the cabrito, and chestnut, and we were seeing incredible results, I knew what was happening in the short term when we were getting the bacteria, the bacterial overgrowth. That's why we developed it. But so many of my patients felt better and better while remaining on it. And now I can explain to them because of your research, what's actually going on. And that's what's so cool. And that's what's so neat that most of the research that is done and you've You know, this are done on smaller phenolic compounds, those ones that we talked about. So they always talk about the same ones over and over course, the 10 reservatrol curcumin those, you took a step back and said, Wait a minute, let's find out what happens when we look at these larger molecules. Definitely. And you use the really cool term because I'm going to start using this building blocks the molecules just a large building block. Yeah. Which is awesome. The when, before we get into your research there, I had to plow through trying to trying to prepare for a paper and some and a podcast of really big article called the immunomodulatory, anti inflammatory antioxidant effects of polyphenols a comparative review on the parental compounds and their metabolites. It's like a 50 page article where all they did is show that no every time you take one of these polyphenols, it does more and it gets broken down into more things. And it was like really thick. And then you I found your article, which do you have more questions? Because I think one of the coolestone of the things that you said that we've said on the show multiple times is you said the word prebiotic, and that's still not really a commonly used word here, at least in the States. Would you mind Silvia kind of explaining what you view is a prebiotic?Yeah. Normally people know that term probiotic. And sometimes there's like a mistake between pre and probiotics. So I could explain it a probiotic. It is like a strange this, our bacteria normally are beneficial bacteria that we can intake. Normally with yogurt or the products. A prebiotic is something that is before the bacteria. So if something is a substance, or for example, fibers that could act on the on the composition of our microbiota. So we are not going to change the composition of our microbiota by taking some external strain of bacteria, but we just want to moderate what we have with prebioticmakes sense. So basically, it's it's almost like the perfect food for the bacteria that we already have. Right? Yeah.If we give to our microbiota, like a good food to to grow well, right.What generally speaking since you've been doing research on this over here, probiotics. It's a massive industry. But just recently, a lot of data is coming out that probiotics probably don't do as much as we used to think, mainly because many of these probiotics that we purchase, don't make it to the colon where your microbiome is, what are with through your research? I'm just curious what your opinion is on probiotics in the use in humans? Well,I think that each person has his own microbiota, and each person needs a specific strain of probiotic. And it's so difficult to do that. Because normally, what we can find in the supermarket is like last bifidobacterium more lactobacillus but is so general, we don't know if that strain is the right strain for us. In the other way, it prebiotic always is good, because it's helping our our on microbiota. So we are going to solve the problem for sure. Well, and then there are other technical problems, for example, the probiotics are not so resistant. So sometimes we can intake a product with probiotics, but they don't have done work. So good.That makes sense.Yeah, that's we've we've done a little bit of research on this, my personal belief is, is that when, when we look at probiotics, we at least know that certain things like a spore based probiotics stays in the spore form. And there is clinical data to show that it can make it to the colon where then it wakes up. And if it's got the prebiotic like a polyphenol with it, the combination helps both of them improve the microbial diversity, or basically they work together.Actually, there's a paper that is in publication. So then I can send it to you. I always working with in vitro, they just send fermentation, I could demonstrate that the intake of tannins caught it improve the diversity of the of the microbiota.It's perfect. That is huge. Hey, out of curiosity, if this paper since you've been doing some of that research, is it possible that not only will the tenants improve the diversity, but will it help raise good bacteria and lower the type of bacteria that we know can create problems?Yeah, we have to know that tannins are really our molecules produced our secondary metabolites from plants. And these metabolites are produced from plants as defense. So these cues are produced to counteract the action of bad guys, such as bacteria, bad bacteria, or other other external factors. And and if we intake tennis is up in the same field. So they are able to detect the bad guys, the bad bacteria. And I don't want to say to kill them that reduce the amount or the activity. And the other part on the other part, they can increase the activity and the functionality of the code guy or the good bacteria.That is awesome. Nobody has said that before like that.No, they haven't. And in fact, it makes perfect sense, because it's not like and Sylvia said this earlier, it's normal for us to have reactive oxygen species, right. But in small amounts, what do tannins do, they keep us from having too much. So you're saying it's not eliminating all of the quote unquote, bad bacteria, it's more or less delivering balance, where we need balanceis a modulation.That's beautiful. It's allowing mother nature to do what it's what it wants to you. We hinted at it at the beginning of the show, but what happens in the pharmaceutical industry is they go, Oh, we want this molecule, let's make a drug out of this tiny molecule and not taking into account that when you give the body what it wants, it will use what it needs to make sure that it keeps you in balance.Yeah, I think that the great thing about the extra toe I'm working with from siba team is that they are Phyto complex. We are not working with just one specific molecule. We are working with a group of molecules so we have multiple action and multiple effect.Let's say you have I have a paper on this specifically and and it really, really piqued my interest. And the reason is because you illustrated and then essentially gave the How to on why a larger parent molecule, which basically would have more of these smaller polyphenols is actually what your body wants, because simply, it begins to pull apart the polyphenols as it needs to use them. Is that is that right? Is that how Am I understanding that correctly?Yeah, yeah, it's correct. and here we can find it another super characteristic often is because we can see that they could art at a local level in the InDesign as big molecule. And these big molecules are the molecules that are that are going into in contact with with a good microbiota. But when they are metabolized, they could give form to smaller metabolites. And these modern metabolites are the responsible doses possible of the systemic effects. Okay. They could pass them through the intestinal barrier, and then extra day they fashion and system 11 in the audience, there isn'tthat kind of what you called post biopsies. Soyeah, that's we're referring to those metabolites as post biotics. So it's the post biotic or the metabolites or the break? Absolutely. So can you do me a favor? I'm, can you explain, I don't know if you can see that. But your little summary, the diagram, but this is what's so cool. And this is what separates Silvia from everybody else, she developed this super eloquent model, can you explain what you did with this, because it's so neat. With in vitro digestion?Well, the in vitro digestion and fermentation are two basic steps. First of all, we have the digestion. In this case, we are mimicking what happened, what's happening in the mouse in the stone much and during this time, we mimic the temperature pH, enzymatic condition that we find in the in the mouth, and then in so much and then in time, okay, then what we obtain from the digestion we take apart, and we put it in contact with the microbiota within inoculum. And then we'll add a permanent state. And then from that, we obtain our sample that we are going to study. So from from these records, we have a resembling matters of that of the human digestion.So in your diagram, so cool, you mixed one to one in the oral phase with salivary fluid, salivary amylase at a certain pH, then you mix it in the gastric phase with gastric fluid pepsin. So a digestive enzyme at a certain Ph. And then in the intestinal phase, you mixed it with intestinal fluid, including pancreatic fluids, like trypsin, and bile, that's fantastic. So all three phases of digestion, then you separated those, and you took one of them, and then you fermented it, to show what happens in the colon.So this part is very important, which is is important to us. And we wrote a paper, I think, in a few days will be published in, in natural protocols.That's incredible. So then you took this fermented you first of all, you took the digestion part, and then you analyze that and then you took the fermented part, you analyzed it, when you say analyzed it, what did you do to analyze it?Well, we could perform every type of analysis, I dedicated my studies about the antioxidant activity of of tannins, just to see how can the digestion and then the fermentation could affect the antioxidant activity exerted by by by tannins, and then I try to understand how these big molecules could be metabolized by our body. So how the structures could be affected by the action of the enzyme enzymes or digestive enzymes and then how these molecules could be affected by the action of the gut microbiota.Okay. Makes sense. So essentially, she was just trying to show the what's going to happen all the way through the entire phase of having a polyphenol.Yeah. Which is so cool because nobody has done this yet, looking at the literature, this is the one thing that I've wanted to see for so long. What happens with these large tannins through digestion and through fermentation? So after fermentation? What did you notice? Like What Did you see when these large building blocks were digested and then fermented?Well, after digestion, and it was a bit surprising that the large molecules, they're still there. But then, after the action of that gut microbiota, we could have said that a lot of small molecules a small metabolized were forming, thanks to the action of the of the of the bacteria bacteria. Okay. Yeah. So we could see the formation of smaller molecules, typical from the idealized Bhutanese or from the combat standings. So we will see an increase in the presence of Corsetti in a gcg, galley kassig, or ellagic acid.This is this is awesome, because just not to veer far. But right now stateside, what people are hearing about on podcast trying to find solutions for people maybe who can't get access to a vaccine, or they have difficulty because they're overly exposed to public, they're getting lots of guidance on utilizing certain polyphenols, like course attended cetera, to function as zinc on a force. But what I'm hearing you say is that you can actually still get that same course. And they'll have your body disassemble a much larger parent molecule or parent poly phenol. Yeah. And your body will essentially pull apart exactly as much as it needs. Is that right?Yeah.Can you do that?Yes, no, no, it's fine. I What I'm saying is, is that your what you illustrated in here, you were able to find these metabolites of the bacteria was able to make use of the poly phenol. Yeah, some of those included the corset in which, over here stateside, now people are hearing about corsten. And its ability to help people with antiviral activity. And what I'm hearing you say, from your research, you can actually get plenty of course it in by having a larger poly phenol that actually has it inside. Is that right?Yeah, actually, we know that our extracts for use from from Suba team are very effective for antiviral activity. And we started to with a big trial clinical trial in Argentina, and what does is trying to give a supplement to COVID patients. And we have the first results, we don't have all the results, but we have the first results about that. And we could have served at first that the passion supplemented with tunings Beside that, then the typical therapy registered and a decrease of the inflammatory status, we registered the crease of for example of some indicators like TNF alpha.That sounds very familiar. And again,very, very, very familiar. Still doing what's really interesting is that this is the first time that anybody has discussed the fact that over here, there's lots of supplements, and the supplements are Oh, get this green tea extract, oh, get this ellagic acid, which will help produce your alisson get this course written. And so I have so many patients that have 20 different bottles in front of them. And they're doing this and then when we realize that no, once again, that's almost a smaller version of what the pharmaceutical companies are doing. It's like, Oh, this molecule was studied here. So I'm gonna go buy that molecule. But when you give the large stable molecule, Mother Nature's secret weapon, then your microbiome will kick off these smaller molecules like this corseted. Now, something that's interesting, I did reference that first study that was really thick. What they did is they did, they did mass spec on these different polyphenolic compounds, including reservatrol, including quercetin and including tumeric. And what they showed is those are poorly absorbed, and they end up having to be broken down also. So it isn't like taking the smaller molecule is a shortcut, it still has to go. The beauty of using a large tannin like this is the prebiotic effect which improves the microbial spectrum. And then the broader the microbial spectrum, the more of these beneficial, smaller phenolic compounds are going to get 100%.And this is just like a bi directional relationship between tannins and microbiota because tannins in some way, we could say that feed the microbiota as prebiotic, by then the other way that that feed, the Fed microbiota is going to metabolize them.A bi directional relationship bi directional relation tannins and by the micro. Yeah, it makes sense. They need each other.Yeah. Frequently, I think of tannins in the microbiome, like the bidirectional relationship that Eric and I have in our friendship. Yeah, I need him he needs me.If it weren't for him, bringing AGI patients, I would just be putting people to sleep for nothing.Yeah, they would just go to sleep and nobody was doing anything. This is what's so cool about this is can you just explain really quick, just so that people don't take your word for it yet, you ended up doing some pretty cool chemistry to determine what molecules were there. So what did you do when you did the fermented how you were able to show that quarter 10 was kicked off that your lifting was kicked off that egcg was kicked offwhat I had to perform before an extraction of the polyphenols. And when I had the sample, I perform an analysis on a uplc ms. That is a huge instrument that allows our allow us to identify exactly every single molecules.So the detectable so she had definitive proof that they were there.That's awesome. Right there. I'm looking at her mask. Right there. Got it in the article.Mass Spectrometry. Yeah,yes. I love that. That is what's that's the thing that I think is going to be the biggest game changer understanding that through your science, really, you can get these other beneficial products through one parent molecule, the building block. And that's what I try to tell my patients like, Well, why don't we take the largest, most stable tannins, right, put them together? And then as you take that, that will not only feed your microbiome, but you'll also produce these other things. And then the metabolites, the other metabolites like, oh, short chain fatty acids?Yeah. Because we don't have us only just the metabolites deriving from the receptors of the big structures. We also have the other secondary metabolites that arise from the action of microbiota. We know from my researches and from other scientific literature, that tan is good in us both microbiota to produce short chain fatty acids. These small molecules are so important for us because they exert a lot of activities, they will be absorbed, and they their main activity is an anti inflammatory effect. But also they are super important for them. Past military maintenance of the sad part of what leaving what been leaving for this house. Yeah,I mean, we're basically on about item number 17. on why polyphenols daily are critically important. And Silvia put it in here in a paper that anybody can read. I mean, this is awesome. 100%, when when you did this article, this is the thing I've been trying to explain to patients for so long. And you showed it very eloquently here, you also have another published study, which is pretty eloquent in itself. And this one is a little bit more related to the thing that we're both very passionate about, which is the brain gut access. Yeah, my my goal as a physician, eventually is to make it so that we protect the brains of people we know that inflammation results in all kinds of different diseases. And you actually published a paper as the lead author, polyphenols in dementia from molecular basis to clinical trials. How did you decide to do How did you decide to do a review article on dementia? That's really cool. That's right in our wheelhouse also, definitely.Well, at the moment, I was working in a lab in Italy. They were specializing in dementia, and they wanted to publish something about about that, and they proposed me to write a paper. And I think that I had inside already that the love for pony feels. At the moment I was working with polyphenols of grapefruit,grapefruit. Oh, yeah.So I started searching something and then I just decided that it's dementia and polyphenols, I started to find a lot of source. So interesting literature and then I could find also clinical trial. So I decided to construct the paper from the molecular basis to explain exactly what's happening and its molecular level until to the clinical trials. What happens in the passions?Well, it's a it's a powerful piece, because essentially, you're outlining that somebody who has had dementia, it's probably have long exposures to inflammation. And then in the paper, you're essentially showing how or why I guess polyphenols are critical.So So in this particular paper, you were looking at the literature. So this was a review. So the literature that was available, looked at those different molecules that were already talking about reservatrol, curcumin and things, and I have to I love how you address this head on you said that the bioavailability of curcumin tumeric, which everybody talks about all the time is very low, because it is poorly absorbed and rapidly metabolized them eliminate and eliminate it. Here one study that talked about this, you go in to describe how reservatrol has very low bioavailability. Everything that you're talking about is exactly what this other article did, where it showed that even these smaller phenolic compounds do that. So we know that there's evidence to show that this can help in dementia. How does it help in dementia, though, let's just so when in your review, how did you figure out that it helped to prevent dementia or assist those people with dementia?What the mechanisms are with are always the same. First of all, we have the antioxidant activity and anti inflammatory activity. What I can say now, after some years, I could say that could be related also to the modulation of the microbiota, because we know that almost 70% of the immune system is in the in dangerous time. Okay, so by regulating the microbiota, by maintaining maintaining a good status in the intestine, and reducing the inflammation there, we could then regulate also the inflammation all over the body and also reducing for sure, the inflammation that can lead to dementia. So it's everything is related.So she used some pretty common terms that you and I have talked about quite a bit, right. Um, thing about Oh, NF Kappa beta. Yeah. CRP lippo, polysaccharides cyclooxygenase. pathway. So that is that definitely summarizes Do we have this thing, open that up real quick, like Sophia, this is what Eric and I did last time. That's all about inflammation and polyphenols and where they help.Yeah, so we I, I drew first and then we realized how bad it was. So we found a young child, a kindergartener walking down the street, better than I did, so we paid them to do this. So it's done by some children.It was another one of those bi directional relationships.bi directional relationship. So this is this is so exciting. Here's why you're doing research, you have shown that the cause of dementia is actually due to inflammation, which we talk about all the time, all the time, diseases, inflammation, cause of cancers inflammation, we have, I have a lot of friends that participate in a lot of combat sports. I have a lot of friends that are former football players. So I have this whole community of people that have had traumatic brain injuries, which I think could really benefit from stuff like this. We know that because of the diet, people have a pro inflammatory diet correct. And you know, when we look at this, that the group of people that I treat a lot are people that have intestinal inflammation through bacterial overgrowth, poor diet, one of the most common things that they talk about or if I asked them is brain fog, or fatigue or anxiety. Yeah. And now we knowthe reason I found in nature tour I can I can send it to you to interesting papers talking about some products that have been developed with tannins for the productivity for the mentality. Oh, Gordon, explain why but I guess it we could do it.But I mean, isn't that something though, they probably stumbled upon it. Not really knowing. And quite honestly, it's your review and some of your other research that's starting to show people the why, which is critically important. Why, you know, why does someone want to do what it is that we're doing with polyphenols and Sylvia's? Honestly, paving the way on on the why it's very powerful.we all we all have heroes. Sylvia, you're my hero, you are proving the things that that we have been trying to I've been trying to explain to my patients. And then now I can go low. I'll refer you to this article. This is why this is also why I think it's important to have a good diet, but also the long term strategy of the longer that you allow your body to access these tannins. Definitely the more your microbial diversity, the more you will block the inflammatory cascade. Yeah,well, inflamed inflammation long term is not an overnight thing. So in order to repair our bodies, you need to consume healthy polyphenols for a long period of time. And then your body gets used to having the tools that it needs to provide your body with the short chain fatty acids or the Euro lessons or the course it cetera, for you to repair and control inflammation it makes, it makes a lot of sense.Yeah, totally.Okay, Sylvia, so I had, I did clinic this morning, and I have a series of patients, and I told them, I said, Don't worry, I'm having one of the smartest scientists in the entire world on the show today. This is an interesting thing, because of your research, I think we can help some of these people. I have a series of patients that have had their colons taken out for various diseases, either, that, for whatever reason, they have no colon. So now they have no microbiome. So now, in fact, I had a patient. My last patient said something really interesting to me. She loves she loved taking artron teal, she said she'd never felt better. And then due to some adverse events, she has an ileostomy so that she's not connected to her colon. And she said today, she's like, I just don't I don't get it. I'm not feeling as good as I used to. And I'm like I do. Because we're not, we're not breaking these down. We're not fermenting them in the way that they should be. So my task to you, how do we develop something for people that do not have the capability of fermenting foods, tannins, prebiotics, to have these beneficial to handle this opportunity to decrease the inflammatory cascade? What do you what pops in your mind of how we can figure something out for these people that don't have access to the microbiome? Am I saying that right?Well, just to understand your question, you are meaning don't have access to microbiome in the senate don't have a white coat microbiota, orno, they have had their colons removed completely. No, yeah. So no large intestine Yeah.Okay. Okay.One of ourone of our prior guests, one of our prior guests, Angie, she said, You got to figure this out with I'm gonna call you Dr. Sylvia. Because you're you're almostyou can go me almost doctorWell, does he go Tada, Silvia de la luna Casa gasi. Dora, that's almost doctor, I'm catchingup.No, but it's something with with your with your research that shows that people with a colon will have a a more beneficial response to prebiotics and to these polyphenols. So is it possible that fermenting them first and then giving that as an absorbablethis could be a possibility. We called what the product should be developed. But it's, it's okay. We could do it in laboratory The name of this product are post biotic as we were saying before, sure. So we could generate directed the metabolites from from Danny's from the big structures in laboratory by fermenting them with an old microbiota outside the body. And then give the to the patient the post biotic so all the fermented Tell the lightsbe interesting to at least try. Because if without having the colon, you have to kind of wonder though, if the passage is quite the same when it comes to only having a small battle. That makes sense.It's extremely, it's extremely complex, and we're seeing it more and more. And so I'm just wondering how, you know, figuring something like this is it's a small community.I can't hear you anymore.Oh, that's because he was on mute. I'm sorry. Well, I was just saying that it is a small community, but people that it's insult to injury, if you have a disease, ulcerative colitis, Crohn's disease, a severe dysmotility, whatever, and you have your colon taken out? That's hard enough. Yeah. And then from then on, how do you make sure that you are able to produce these metabolites, which decrease your inflammatory pathway? Sure.And you need them systematically?Yeah. It's just something that I dealt with this morning. And I said, I have the person has the answer. How long do you think it'll take you to develop this product? And then get it back to me so that I can start helping my patients? I told him, I told him about a week. Yeah, cuz gosee looked at I Silvia can do anything.As soon as I finish my thesis, I can start with the project.And nothing doesn't do it at all. Well,this is exciting. This is super cool. Yeah. Sylvia, your your research is incredible. I think that you're just getting warmed up, I think that you have shined a light in an area that many of us can start looking at and start talking about in a very scientific way. And it isn't just Oh, go out and buy this marketing product over here. We want to we want to educate people through science. And that's what you're doing over here. So 100, right.And I just think it's so cool that you are able to where people are already turning to polyphenols, and we mentioned ecgc and in quercetin before, and we've all been trying to compete on how do we get our body to use these nice, awesome poly phenol molecules. And really, you just took a step back and said, Guys, you really want this bigger one. Because by using this bigger poly phenol, your body is actually going to get a better bioavailability of everything that you think that you need. And it's, it's, it's awesome. And it put it into practice. And quite honestly, this is a theme that we've seen before, over and over and over again, where we tried to give women who are who are in need of a folic acid, and they put folic acid in a little, a little pill. So they're while they're pregnant, that they don't have, you know, some some birth defects. But the truth is your body wants full eight, not necessarily folic acid. So once again, it's it's the bigger molecule that it's natural that your body wants. And what you did is you just basically took that same science and just blasted it into polyphenols. I think it's awesome.We're going to, we're going to get you hooked up, we had a meeting with the author of the cert diet, which in your article, you actually describe how these polyphenols were turned on the sirtuin pathway as well. And so that is a whole nother aspect of almost an epigenetic process that goes on with it. But the other really cool thing is you talked about how these polyphenols increased nitric oxide both Eric and I like to exercise so we take our polyphenols for the nitric oxide capability. So all right, Cassie dotata Silvia does Michaela let you do anything. What do you like to do for fun when you're not always working on your thesis?You You talked to us?Because that's because I'm speaking Spanglish. gasi Dr. Sylvia? Yeah.Are Spanish or English.We, I want to know does other than working on your thesis and working from a Khaleda? What do you like to do for fun?This is my phone.My phone?Well, I in my free time, I'm an athlete. I'm a triathlete. Oh,yeah. Are you taking your polyphenols while you train and recover?Working on me to develop new supplements with Thomas.Oh, look at that. Nice. Yeah.Yeah, they are so useful. So for first of all to people, because for sports that requires a lot of exercise like triathlon for example. The the body is always always trust and the development of oxidative stress and inflammation is huge. So We are used to take just supplements with carbohydrates or proteins they are giving us just micronutrients but they are not thinking about macronutrients or polyphenols, some some molecules that could help us to reduce the fatigue and to help us to recovery.What's the most challenge? What's the most challenging event that you've done in a triathlon? Have you done like an Iron Man orI'm sorry to interrupt you soyou can fit those in a little bit quicker to understand.I come from autism I before when when I was young, I was a sprinter. So for me, an Olympic distance of triathlon is just like a mortal now.I think that your research is really important because Eric tried doing some triathlons also. And he understood the power of polyphenols. But the only one that he had read about was reservatrol. So he was drinking wine the entire time that he was doing the triathlondata, remember?Before to cycle in, it's not the road.Well, I don't remember any of it. So it's okay.Well, Sylvia, thank you so much for joining the gacek project. This is exactly what I wanted to talk about. You did an incredible job. Your your research is amazing. And I feel like you're just getting warmed up. I feel like she's going to continue to uncover a lot of different things.Yeah, what an awesome show to have you join us and and for all of you as a gut check project, like normal, we will put Sylvia's research in the show notes so that if you would like to see her own articles yourself or some of the others that they can reference. That way, you know, that we're not just we're not just speaking, it's, there's there's lots of powerful information in here. And I just can't thank you enough Sylvia, for making time to hop on with us today. It'sbeen it's been awesome. And if you're, if you're listening to this, as always, you know, share this with people, it's super important information that this is an incredible opportunity to have somebody like sylviane explaining this intricate science. So if you know somebody that has intestinal health problems, if the autoimmune problems, inflammation, possibly risking dementia, things like that, this is really important stuff that they all need to hear,definitely. Or if you think that you're in the market for trying some type of new polyphenol or course it's in or you're going to green tea to get ecgc maybe just reconsider re listen to this particular episode. And I think that we can help you with artron to find a much better larger poly phenol, that Believe it or not, Silvia here has researched thoroughly. She knows it very, very well. So,Sylvia, can we be can we be a sponsor for your next triathlon? I'll try to just give her the whole logos everywhere. AndI think that the corporate office is gonna love the fact that you've already committed so I guess we'reworking for my new uniform so we can talk about it. Oh, I'msorry. I think we're a little mistake. Oh, and I mean, sponsor, the only sponsors we get are people that actually get tattoos.Yeah, yeah, you we. He wants to give you a tattoo of altro until it's kind of a permanent sponsorship.That's awesome, Sylvia. So much. Hey, don't hang up yet. But everyone else thank you so much for joining. Gotcha project number 49. And like I said, we'll make everything available to everything else to answer it.No, I'm just loving it. Loving everything. I thought it would be. All right.Thank you all very much, Silvia. Don't go anywhere. Bye bye.

Episode 7 - My first visit to Europe, and that was Granada, Spain

Play Episode Listen Later Jan 8, 2021 19:28

In this episode I will tell about my adventures in Granada, the first city I've visited in Europe and that was all led by my Flamenco passion. I will speak about Paco de Lucia, Emilio Maya, the fantastic Albaicin and Sacromonte. Also, one of my references of Flamenco, who also is an outstanding Choro & Samba player, Fernando de La Rua. An interesting story will come up on how I got my flamenco guitar from the great guitar maker (guitarrero) German Perez. --- Send in a voice message: https://podcasters.spotify.com/pod/show/abdallah-harati/message

europe paco granada samba flamenco choro first visit granada spain sacromonte

The Gary Null Show - 08.19.20

Making Pittsburgh Healthy

Play Episode Listen Later Aug 19, 2020 47:49

The Gary Null Show is here to inform you on the best news in health, healing, the environment. Multivitamin, mineral supplement linked to less-severe, shorter-lasting illness symptoms Oregon State University, August 18, 2020 Older adults who took a daily multivitamin and mineral supplement with zinc and high amounts of vitamin C in a 12-week study experienced sickness for shorter periods and with less severe symptoms than counterparts in a control group receiving a placebo. The findings by Oregon State University researchers were published in the journal Nutrients. The research by scientists at OSU's Linus Pauling Institute involved 42 healthy people ages 55 to 75 and was designed to measure the supplement's effects on certain immune system indicators. It also looked at bloodstream levels of zinc and vitamins C and D while taking the supplement, as these micronutrients are important for proper immune function. The immune indicators, including white blood cells' ability to kill incoming pathogens, were unaltered in the group receiving the supplement. The multivitamin group showedimproved vitamin C and zinc status in the blood. Most intriguingly, illness symptoms reported by this group were less severe and went away faster than those experienced by the placebo group. The same percentage of participants in each group reported symptoms, but days of sickness in the supplement group averaged fewer than three compared to more than six for the placebo group. "The observed illness differences were striking," said corresponding author Adrian Gombart, professor of biochemistry and biophysics in the OSU College of Science and a principal investigator at the Linus Pauling Institute. "While the study was limited to self-reported illness data and we did not design the study to answer this question, the observed differences suggest that additional larger studies designed for these outcomes are warranted - and, frankly, overdue." As people get older, the risk of vitamin and mineral deficiencies that contribute to age-related immune system deficiencies rises. Across the United States, Canada and Europe, research suggests more than one-third of older adults are deficient in at least one micronutrient, often more than one. "That likely contributes to a decline in the immune system, most often characterized by increased levels of inflammation, reduced innate immune function and reduced T-cell function," Gombart said. "Since multiple nutrients support immune function, older adults often benefit from multivitamin and mineral supplements. These are readily available, inexpensive and generally regarded as safe." The multivitamin supplement used in the study focused on vitamins and minerals typically thought to help immunity. It contained 700 micrograms of vitamin A; 400 international units of vitamin D; 45 milligrams of vitamin E; 6.6 milligrams of vitamin B6; 400 micrograms of folate; 9.6 micrograms of vitamin B12; 1,000 milligrams of vitamin C; 5 milligrams of iron; 0.9 milligrams of copper; 10 milligrams of zinc; and 110 micrograms of selenium. "Supplementation was associated with significantly increased circulating levels of zinc and vitamin C, and with illness symptoms that were less severe and shorter lasting," Gombart said. "This supports findings that stretch back decades, even to the days of Linus Pauling's work with vitamin C. Our results suggest more and better designed research studies are needed to explore the positive role multivitamin and mineral supplementation might play in bolstering the immune system of older adults." Honey found to be a better treatment for upper respiratory tract infections than traditional remedies Oxford University, August 19, 2020 A trio of researchers at Oxford University has found that honey is a better treatment for upper respiratory tract infections (URTIs) than traditional remedies. In their paper published in BMJ Evidence-based Medicine, Hibatullah Abuelgasim, Charlotte Albury, and Joseph Lee describe their study of the results of multiple clinical trials that involved testing of treatments for upper respiratory tract infections (URTIs) and what they learned from the data. Over the past several years, the medical community has grown alarmed as bacteria have developed resistance to antibacterial agents. Some studies have found that over-prescription of such remedies is hastening the pace. Of particular concern are antibacterial prescriptions written for maladies that they are not likely to help, simply due to demands from patients. One such case is often URTIs, the vast majority of which are caused by viruses, not bacteria. Because of such cases, scientists have been looking for other remedies for these infections, and one therapy in particular has begun to stand out: honey. Anecdotal evidence has suggested that honey can be used to treat colds in general and coughs in particular—people have been using it as a therapy for thousands of years. In this new effort, the researchers looked at the results of multiple clinical trials testing the effectiveness of therapies against URTIs. In all, the team looked at data from 14 clinical trials involving 1,761 patients. In analyzing the data from all of the trials combined, the researchers found that the trials had included studies of virtually all of the traditional remedies such as over-the-counter cold and sinus medicines as well as antibiotics—and honey. They found that honey proved to be the best therapy among all of those tested. In addition to proving more effective in treating coughing (36 percent better at reducing the amount of coughing and 44 percent better at reducing coughing severity), it also led to a reduction in average duration of infection by two days. The researchers note that the reason honey works as a treatment for URTIs is because it contains hydrogen peroxide—a known bacteria killer—which also makes it useful as a topical treatment for cuts and scrapes. Honey is also of the right consistency—its thickness works to coat the mouth and throat, soothing irritation. High intensity physical activity in early life could lead to stronger bones in adulthood University of Bristol (UK), August 17 2020 The research, which analysed data from 2,569 participants of the Children of the 90s health study, found that more time spent doing moderate-to-vigorous intensity physical activity (MVPA) from age 12 years was associated with stronger hips at age 25 years, whereas time spent in light intensity activity was less clearly associated with adult hip strength. Peak bone mass occurs in young adulthood and is considered to be a marker of the risk of fracture and osteoporosis in later life. Hip fractures make up a large proportion of the osteoporosis disease burden. Researchers looked at data from healthy individuals who had physical activity measured up to 4 times using accelerometers worn as part of clinical assessments at age 12, 14, 16 and 25 years. This is a device that measures a person's movement for the whole time they wear it. Researchers also found evidence to suggest that adolescent MVPA was more important than MVPA in adulthood, and that MVPA in early adolescence may be more important than in later adolescence. There was also some evidence that higher impact activity (consistent with jumping; assessed once in a subsample in late adolescence using custom accelerometer) was related to stronger hips at age 25. Dr Ahmed Elhakeem, lead author and Senior Research Associate in Epidemiology, said: "The unique availability of repeated accelerometer assessments over many years beginning at age 12 within the Children of the 90s cohort, allowed us to describe the trajectory of time spent in different physical activity intensities through early life and to examine how this might relate to adult hip strength. The results highlight adolescence as a potentially important period for bone development through high intensity exercise, which could benefit future bone health and prevent osteoporosis in later life. We have also confirmed other studies showing that levels of MVPA decline through adolescence. Our findings show it is really important to support young people to remain active at this age" Francesca Thompson, Clinical and Operations Director at the Royal Osteoporosis Society (ROS), said: "The ROS is working closely at the moment with Public Health England to review the importance of exercise for bone health in children. The findings from this study are welcome as they provide further evidence that children need to be doing moderate to vigorous intensity physical activity during their early adolescence to maximise bone strength in later life and reduce the risk of painful fractures. Supporting and encouraging young people to be more physically active needs to be a priority for bone as well as general health." Magnesium supplementation associated with improved vitamin D status in postmenopausal women University of Granada (Spain), August 17, 2020 According to news originating from Granada, Spain, the research stated, “Menopause is a stage of hormonal imbalance in women which, in addition to other physiopathological consequences, poses a risk of deficiency of key micronutrients such as magnesium and vitamin D.” Our news editors obtained a quote from the research from University of Granada: “A study was made of the influence of a magnesium intervention upon vitamin D status in a postmenopausal population from the province of Granada (Spain). Fifty-two healthy postmenopausal women between 44-76 years of age were included. Two randomized groups-placebo and magnesium (500 mg/day)-were treated during eight weeks. Nutrient intake was assessed using questionnaires based on 72-h recall. Vitamin D was analyzed by liquid chromatography-tandem mass spectrometry. Baseline vitamin D proved deficient in over 80% of the subjects.” According to the news editors, the research concluded: “The administration of magnesium resulted in significantly increased vitamin D levels in the intervention group versus the controls (* * p* * < 0.05). Magnesium supplementation improved vitamin D status in the studied postmenopausal women.” High fructose diet in pregnancy impacts metabolism of offspring, study finds University of Otago (New Zealand), August 18, 2020 An increased level of fructose intake during pregnancy can cause significant changes in maternal metabolic function and milk composition and alter the metabolism of their offspring, researchers from the University of Otago, Wellington, have found. The research, which was led by Dr Clint Gray, a Research Fellow in the Department of Paediatrics and Child Health, found increasing the fructose in the diets of female guinea pigs led to highly significant and consistent changes in the free fatty acids circulating in the blood of their offspring. This was despite the offspring consuming no fructose themselves. The research is published in the international journal Frontiers in Endocrinology. First author, PhD student Erin Smith, says "previous research has shown poor quality nutrition during pregnancy can predispose offspring to long-term consequences, including the development of obesity, diabetes and cardiovascular disease later in life". "However, there has been a lack of data examining the impact of increased fructose intake before and during pregnancy and subsequent adverse effects on lactation, foetal development and offspring metabolic function." The two experimental groups were fed either a control diet or a fructose diet prior to and during pregnancy. The fructose group was given supplementary fructose water to replicate increased sugar-sweetened beverage intake 60 days prior to mating and until the delivery of their offspring. Fructose made up 16.5 per cent of their diets, closely resembling the average human consumption of fructose/sugar in Western countries, which is estimated at about 14 per cent of average daily caloric intake. "We found fructose had a significant impact on a pregnant females' metabolic status and the free fatty acid content of their milk. We also provide the first evidence that offspring born from fructose-fed mothers display a very specific pattern of increased free fatty acids and altered lipid metabolism that persists throughout early life." Ms Smith says it is well known that increased levels of circulating free fatty acids increases the risk of obesity, insulin resistance, type 2 diabetes and cardiovascular disease - with increased fatty acid synthesis shown to occur following fructose consumption. She says the evidence suggests suboptimal maternal diets, such as diets high in fructose and refined sugars, may be contributing to the rise in metabolic diseases in humans observed during the past 40 to 50 years. "Our study emphasises the importance of limiting added refined fructose, such as sugar-sweetened beverages, and striving for a more nutritionally balanced diet in women prior to and during pregnancy and lactation." Sleep makes relearning faster and longer-lasting University of Lyon (France). August 14, 2020 Getting some sleep in between study sessions may make it easier to recall what you studied and relearn what you've forgotten, even 6 months later, according to new findings from Psychological Science, a journal of the Association for Psychological Science. "Our results suggest that interleaving sleep between practice sessions leads to a twofold advantage, reducing the time spent relearning and ensuring a much better long-term retention than practice alone," explains psychological scientist Stephanie Mazza of the University of Lyon. "Previous research suggested that sleeping after learning is definitely a good strategy, but now we show that sleeping between two learning sessions greatly improves such a strategy." While studies have shown that both repeated practice and sleep can help improve memory, there is little research investigating how repetition and sleep influence memory when they are combined. Mazza and colleagues hypothesized that sleeping in between study sessions might make the relearning process more efficient, reducing the effort needed to commit information to memory. A total of 40 French adults were randomly assigned to either a "sleep" group or a "wake" group. At the first session, all participants were presented with 16 French-Swahili word pairs in random order. After studying a pair for 7 seconds, the Swahili word appeared and participants were prompted to type the French translation. The correct word pair was then shown for 4 seconds. Any words that were not correctly translated were presented again, until each word pair had been correctly translated. Twelve hours after the initial session, the participants completed the recall task again, practicing the whole list of words until all 16 words were correctly translated. Importantly, some participants completed the first session in the morning and the second session in the evening of the same day ("wake" group); others completed the first session in the evening, slept, and completed the second session the following morning ("sleep" group). In the first session, the two groups showed no difference in how many words they could initially recall or in the number of trials they needed to be able to remember all 16 word pairs. But after 12 hours, the data told another story: Participants who had slept between sessions recalled about 10 of the 16 words, on average, while those who hadn't slept recalled only about 7.5 words. And when it came to relearning, those who had slept needed only about 3 trials to be able to recall all 16 words, while those who had stayed awake needed about 6 trials. Ultimately, both groups were able to learn all 16 word pairs, but sleeping in between sessions seemed to allow participants to do so in less time and with less effort. "Memories that were not explicitly accessible at the beginning of relearning appeared to have been transformed by sleep in some way," says Mazza. "Such transformation allowed subjects to re-encode information faster and to save time during the relearning session." The memory boost that participants got from sleeping between sessions seemed to last over time. Follow-up data showed that participants in the sleep group outperformed their peers on the recall test 1 week later. The sleep group showed very little forgetting, recalling about 15 word pairs, compared to the wake group, who were able to recall about 11 word pairs. This benefit was still noticeable 6 months later. The benefits of sleep could not be ascribed to participants' sleep quality or sleepiness, or to their short-term or long-term memory capacity, as the two groups showed no differences on these measures. The results suggest that alternating study sessions with sleep might be an easy and effective way to remember information over longer periods of time with less study, Mazza and colleagues conclude. Meta-analysis adds evidence to chromium supplementation's glucose control benefits in diabetics Lorestan University of Medical Sciences (Iran), August 15, 2020 A systematic review and meta-analysis published on July 27, 2020 in Pharmacological Research found reductions in fasting plasma glucose, insulin, hemoglobin A1c (HbA1c, a marker of long term glucose control) and insulin resistance in men and women with type 2 diabetes who supplemented with the mineral chromium. For their analysis, Omid Asbaghi of Lorestan University of Medical Sciences and colleagues selected 23 randomized, controlled trials that evaluated the effects of supplementing with chromium on various glycemic control indexes. Doses used in the studies ranged between 50 micrograms (mcg) and 1,000 mcg per day consumed from four to 25 weeks. Eleven of the trials evaluated a chromium dosage within a 400 to 600 mcg range. Analysis of 22 trials that reported fasting plasma glucose levels concluded that chromium supplementation was associated with an average reduction of 19.0 milligrams per deciliter (mg/dL) in comparison with the placebo. Trials of at least 12 weeks duration were associated with a far greater average decrease of 58.74 mg/dL in association with chromium. Of the 14 trials that reported insulin levels, levels declined by an average of 1.7784 µIU/mL among subjects who received chromium compared to the placebo, with trials that lasted 12 weeks or longer associated with a decrease of 3.47 µIU/mL. For the 22 trials that reported HbA1c, supplementation with chromium was associated with an average decrease of 0.71%, which improved to a significant 1.70% reduction when trials of 12 weeks duration or more were examined. Homeostatic model assessment for insulin resistance (HOMA-IR) also decreased significantly among participants who received chromium. The authors observed that chromium plays a role in carbohydrate and lipid metabolism and may enhance insulin sensitivity. Other nutrients that have been associated with a lower risk of type 2 diabetes include vitamins A, C, D and E, beta-carotene, calcium, magnesium, potassium and zinc. “Present systematic review and meta-analysis of all available published randomized trials up to 2020 found a significant reduction in all glycemic control indices such as fasting plasma glucose, insulin, HbA1c and HOMA-IR levels after chromium supplementation,” they wrote. “Furthermore, long term intervention contributed to greater reduction of all mentioned indices.” “The results of the current meta‐analysis study might support the use of chromium supplementation for the improvement of glycemic control indices in T2DM patients,” they concluded. Mangiferin: The Health-Boosting Antioxidant in Mangos GreenMedInfo, August 12th 2020 Mangiferin, a polyphenol found in mango fruit and plant extracts, possesses potent antioxidant and anti-inflammatory properties. Mangiferin has been shown to have beneficial effects on gastrointestinal health, Type 2 diabetes and cardiovascular health, and may have anticancer properties Mango, a type of juicy stone fruit native to eastern Asia and India, is rich in omega-3 and omega-6 fatty acids, fiber, antioxidants, micronutrients and minerals, and a unique polyphenol called mangiferin.[i] While mango itself has long been touted for its health benefits, researchers are becoming increasingly interested in mangiferin, which can be found in the leaves, fruit, stone, kernel and stems of the mango plant.[ii] Studies show that mangiferin extracts may have beneficial effects on lifestyle-related disorders and degenerative diseases, and researchers are eager to understand and utilize this potent polyphenol. Antioxidant and Anti-Inflammatory Potential of Mangiferin Mangiferin is a powerful antioxidant that modulates glucose metabolism and shows enhanced antioxidant capabilities in both inflammatory and pro-inflammatory conditions.[iii] Mangiferin antioxidants have also been shown to protect against liver damage and lower peroxidation in human peripheral blood lymphocytes, and mangiferin may have radioprotective properties thanks to its ability to suppress free radicals in cells.[iv],[v] Additionally, mangiferin's anti-inflammatory benefits have been demonstrated in both the liver and heart, and researchers have discovered that mangiferin can protect against lipid peroxidation and oxidative stress by up-regulating the expression of Nrf2, a transcription factor responsible for the regulation of protective antioxidants and detoxification responses.[vi],[vii] Mangiferin's anti-inflammatory effects have also been demonstrated in the lungs, where it can improve acute lung injury by reducing systemic and pulmonary inflammationresponses.[viii] Overall, mangiferin's anti-inflammatory properties have been demonstrated to reduce both macro and microscopic damage in various organs and tissues, making it a potential preventative therapy for a variety of disorders.[ix] Many of the benefits of mangiferin come from these strong antioxidant and anti-inflammatory properties. Researched benefits of mangiferin include: Mangiferin Extract May Protect Against Diabetes More than 80% of all diabetes cases are Type 2, which is associated with a lowered ability to increase glucose utilization in skeletal muscle tissue and adipose tissue.[x] This decrease in glucose metabolism and increased insulin increases the risk for disorders like cardiovascular disease, fatty liver and renal diseases.[xi] In one study, researchers demonstrated that mangiferin extract significantly reduced kidney weight while enhancing enzymatic activity and protein expression after just nine weeks.[xii] Other studies have shown that mangiferin extract can also reduce low-density lipoprotein (LDL) cholesterol and improve oral-glucose tolerance after just 28 days.[xiii] Mangiferin Boosts Gastrointestinal Health Mangiferin has gastroprotective effects, leading researchers to believe it could be a useful therapeutic measure against gastric complications including diarrhea, abdominal pain, weight loss and anemia associated with Crohn's disease and ulcerative colitis.[xiv] These effects are likely due to mangiferin's antioxidant and anti-inflammatory properties, which both contribute to the development of gastrointestinal disorders.[xv] In other studies, researchers have found that mangiferin improves postoperative ileus, a short-term disturbance of gastrointestinal motility after surgery.[xvi] Mangiferin improves intestinal transit by reducing the intestinal inflammatory response and decreasing pro-inflammatory cytokine levels in the plasma, improving gastrointestinal transit in both normal and constipated subjects.[xvii],[xviii] Mangiferin Has Anticancer Properties Researchers believe that one root cause of carcinogenesis is oxidative stress and have long searched for natural, polyphenolic antioxidant compounds that could mediate oxidative damage in the body. One study found that mangiferin's antioxidant capabilities may stall the progression of carcinogenesis and induce apoptosis (cell death) on cancer cells.[xix] Mangiferin is demonstrated to have protective effects against several cancers, including breast, colon, neural, skin and cervical cancers, by lowering oxidative stress and suppressing DNA damage in cells in various studies.[xx] Mangiferin Has Immunomodulatory Properties Mangiferin's strong immunomodulatory characteristics come from its ability to both reduce oxidative stress in lymphocytes, neutrophils and macrophages, and also enhance the number and activity of immune cells in your body.[xxi],[xxii] Additionally, mangiferin inhibits lipid peroxidation, which researchers believe may account for the reduction of radiation-induced DNA damage to immune cells and explain mangiferin's strong immune-stimulating and anticancer effects.[xxiii] Mangiferin Protects Against Cardiovascular Disease Mangiferin may play a significant cardiovascular-protective role by decreasing fatty acids, cholesterol and triglycerides and decreasing the inflammatory process in heart tissue.[xxiv] Mangiferin treatment is also shown to increase enzymatic activity and reduce the formation of lipid peroxides, which researchers use as a marker for cardiovascular disease risk and vascular cognitive impairment disorders.[xxv] Given that mangiferin exhibits little to no toxicity and has anti-inflammatory and antioxidant benefits, there is strong evidence that mangiferin can be used as an alternative or preventive therapy against a variety of illnesses.[xxvi] However, it has a low water solubility and oral bioavailability and researchers must find an effective dosage and enhance its absorption rate before it can effectively be used in clinical settings.

#7 Alcohol is Sh!t - Paul Churchill

Play Episode Listen Later Jun 11, 2020 50:04

In 2006, Paul Churchill moved to Granada Spain where he purchased a bar. In the following three years he became a dependent on alcohol, blacking out close to 7 nights per week. In 2009, Paul walked away from the bar hoping a geographical cure would curtail the drinking, but continued to drink for another 5 years. In February, 2015 Paul launched the Recovery Elevator podcast as an accountability tool to stay sober. Today, it's been over 5 years since Paul had his last drink of Alcohol and the podcast has surpassed 5 million downloads. The Recovery Elevator podcast is in the 97th percentile out of all podcasts on iTunes, has been downloaded in all 50 states and over 145 countries. The Recovery Elevator podcast has evolved into a private membership community with over 1,000 members from all over the world. Paul has spoken to thousands of students about alcohol awareness across the country. Along with putting on alcohol-free wellness retreats and seminars across the country, he hosts sober travel itineraries across the globe. Paul is the author of the best selling book Alcohol is SH!T, has delivered two Tedx talks, was a featured speaker at My Brave in Los Angeles and plans to continue eradicating the stigma surrounding alcohol and addiction. Connect with Paul Churchill: Website: https://www.recoveryelevator.com Paul Churchill paul@recoveryelevator.com www.recoveryelevator.com https://www.facebook.com/recoveryelevator Join us in Making Pittsburgh Healthy: www.makingpittsburghhealthy.com Facebook: https://www.facebook.com/MakingPittsburghHealthy/ Instagram: https://www.instagram.com/makingpittsburghhealthy/ YouTube: https://www.youtube.com/c/draarontressler Don't forget to subscribe, rate & review the show! (:

los angeles alcohol tedx sh recovery elevator paul churchill my brave granada spain

EUROTRIP PART TWO - Granada, Spain

Press Play w/Tristan and Stefani

Play Episode Listen Later May 11, 2020 33:33

#Europe #Granada #Spain Welcome back to another episode of Press Play w/ Tristan & Stefani! In part two of our Euro-Trip series, we talk about our experience in our favorite city - Granada, Spain. Fun fact, Stef studied abroad here for a year back in 2012, so it was super special for her to be there with Tristan! Thanks for listening! Listen on Apple Podcasts: https://podcasts.apple.com/us/podcast/press-play-w-tristan-and-stefani/id1507716624 ----------- Follow us on Social Media! Instagram: @tristan.stefani Twitter: @tristan_stefani

social media fun spain granada stef press play stefani eurotrip granada spain

LOBSTERZ SERIES #015 - FELIPE COBOS

Lobsterz

Play Episode Listen Later Feb 12, 2020 108:00

Born in Granada (Spain), Felipe Cobos begins its relationship with electronic music in 2006, when he began to exhibit his passion in underground clubs, and share cabin with top international artists. In this mix he demonstrates solid, casual and smooth vibe, playing records from his vinyl and digital collections. Bon appetit! SC: @wwwpipes FB: http://www.facebook.com/FelipeCobosMusic

deep tech bon minimal cobos granada spain microhouse

She came out as a lesbian after being raised Mormon, getting married and having a child - with Amber Ezell

At A Crossroads with The Naked Podcaster

Play Episode Listen Later Jan 24, 2020 58:35

Amber and I discuss starting a business, fighting depression, living abroad, getting married, being a lesbian, getting divorced and living her truth. IN AMBERS WORDS I am in a place of life in which I am so proud that I am finally living my truth. It has been a rocky road, mainly due to me trying to fight my inner authentic self. I was born and raised in South Orange County, California. I was also raised in a very conservative, Mormon family, where doing what was "right" was always the most important- far before being authentic. I am the oldest of four kids in my family, meaning I have always been the one with the hardest expectations placed on me and on myself. I went to Cal State University, Long Beach for my undergraduate degree. I developed an intense attraction to my first roommate in college but didn't know what it meant. I admitted in my journal all of the feelings I was experiencing and even wrote “I might be a lesbian” but somehow talked myself out of that crazy idea. I decided I wanted a family and kids and didn't see how that could be possible. I studied abroad in Granada Spain for a year. I learned Spanish as well as how to be on my own in a foreign country. I got through depression and home-sickness the first couple months through intensive journaling and embracing Spanish culture and language. I got married and had a child and then the realization that I wasn't living my truth hit me. Now, I have a four-year-old daughter and am a full-time portrait and wedding photographer. I started photographing families and weddings when I was staying at home with our daughter when she was an infant. The last couple of years have been a crazy quest to live my truth. I finally admitted to myself that I am gay and could not continue to stay married to a man. I decided to go full-time with my business that I hadn't had the time to nurture over the last couple years. I feel now I am finally living congruent to who I am in every way. I have given into who I am. I am a gay woman. I am a Photographer. I am a Mother. I am a Creative. I am an Entrepreneur. FIND HER HERE: facebook.com/amberezellphotography amberezellphotography.com --- Send in a voice message: https://anchor.fm/the-naked-podcaster/message Support this podcast

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Yosef ibn Naghrela - Son of Shmuel HaNagid and Vizier of the Kingdom of Granada, Spain (1035-1066): A Brilliant and Tragic Figure in the Golden Age of Spanish Jewry.

Jewish History with Rabbi Dr. Dovid Katz

Play Episode Listen Later Jan 13, 2020 43:14

How not to avoid antisemitism in a gentile world.

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3 Festival Quiquiriquí Granada (Spain) con Yanisbel Fernández por David

TitirionetaS el Podcasts

Play Episode Listen Later Oct 5, 2018 26:36

En el episodio 3 presentamos otras de los contenidos que ofreceremos: Entrevistas a directores, directoras de festivales de títeres. Queremos saber la singularidad de cada uno de ellos David es un titiritero de ámbito internacional y lleva años recorriendo los principales festivales del mundo, es una oportunidad única para hablar insitu con las directoras y directores artísticos hoy conocerás a… ...Yanisbel Martínez de la Compañía Etcétera que nos presentará el Festival Internacional de Títeres Quiquiriquí que dirige junto a Enrique Lanz en Granada en el Centro Federico García Lorca. En la edición del 2018 el Festival Quiquiriquí se celebra del 28 de septiembre al 7 de octubre. Perdonen los ruidos de fondo, la grabación se realizó en medio del propio desmontaje tras la actuación de la compañía en el Festival Internacional de Títeres de Redondela done David coincidió Yanisbel. Escucha el episodio, esperemos que os sirva para conocer los entresijos del festival y la implicación que tienen algunas compañías titiriteras que no se conforman solo con producir espectáculos, sino que se lanzan a la organización de estos eventos para suerte de compañías y espectadores. Esperamos que os guste y que os sirva para conocer un poco más a los protagonistas de esta profesión. Y recordarte nuestra página web: titirionetas.com. donde puedes suscribirte para no perder detalle de todo lo que se está cocinando en el portal. También esperamos tus comentarios que nos servirán para ir mejorando y llenando de valor este espacio del noble arte del teatro. Esto acaba de comenzar. Escríbenos, comenta, comparte… ¡Acompáñanos! Soy José Diego Ramírez de la compañía Alasombrita.com que junto a David Zuazola dirigimos titirionetas.com El portal de los títeres, las marionetas y sus artífices. Hasta el próximo Episodio --- Send in a voice message: https://anchor.fm/titirionetas/message

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Granada, Spain: Reconquista Legacies

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Play Episode Listen Later Sep 5, 2018 2:32

Granada, Spain's cathedral facade, built shortly after the Reconquista, declares triumph for the victorious Christian forces. The adjacent Royal Chapel provided a fitting resting place for Queen Isabella of Castile and King Ferdinand of Aragon, who ruled during the final Reconquista victory. At http://www.ricksteves.com, you'll find money-saving travel tips, small-group tours, guidebooks, TV shows, radio programs, podcasts, and more on this destination.

Granada, Spain: Reconquista Legacies

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Play Episode Listen Later Sep 5, 2018 2:32

Travelling In Granada, Spain, Episode 38

Road To Empire

Play Episode Listen Later Sep 2, 2018 9:12

Live In Granada, Spain

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Granada, Spain: Albayzín and Alcaicería

Play Episode Listen Later May 30, 2018 2:53

The Albayzín in Granada is Spain's best old Moorish quarter, with its labyrinthine back lanes and inviting neighborhood squares. The Alcaicería, or silk market, is a tourist trap housed in a modern reconstruction of the original market – but it's fun to explore. At http://www.ricksteves.com, you'll find money-saving travel tips, small-group tours, guidebooks, TV shows, radio programs, podcasts, and more on this destination.

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Granada, Spain: Albayzín and Alcaicería

Play Episode Listen Later May 30, 2018 2:53

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Paula Cazenave @ Industrial Copera (Granada, Spain) NYE // 31-12-2017

Play Episode Listen Later Jan 29, 2018 127:08

Here you can find some techno sets recorded by Paula Cazenave.

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Paula Cazenave @ Industrial Copera (Granada, Spain) NYE // 31-12-2017

Play Episode Listen Later Jan 29, 2018 127:08

Here you can find some techno sets recorded by Paula Cazenave.

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Paula Cazenave @ Industrial Copera (Granada, Spain) NYE // 31-12-2017

Play Episode Listen Later Jan 29, 2018 127:08

Here you can find some techno sets recorded by Paula Cazenave.

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Enchanted by Silk

Enchanted By Sewing

Play Episode Listen Later Jun 19, 2017 26:14

I'm enchanted by silk. Pensamientos Primeros/First Thoughts: What is silk and where might it come from? Exploring an historic Japanese Minka Folk House. Technicos/Techniques – Furoshiki: A no-stitch creation from silk - Marriage of ancient Japanese practicality and art Pensamientos Finales/Final Thoughts – Dreaming of a Superfluity of Silks in the Alcaiceria Bazaar of Granda Spain - home to the Alhambra Palace ~ ~ ~ Resources !~ ~ ~ What was the fibula reference? http://meencantacoser.blogspot.com/2017/04/before-safety-pins-there-were-fibulas.html 1) Pensamientos Primeros/First Thoughts - Links Silk was one of the Animal Fibers in this exhibit, which I loved, at the Met http://www.metmuseum.org/exhibitions/listings/2016/animal-fibers http://www.metmuseum.org/exhibitions/listings/2016/animal-fibers/exhibition-themes http://www.metmuseum.org/exhibitions/objects?exhibitionId={118765DF-EE1C-4F92-9606-27916C0763AB} PUSH THE PLUS BUTTON to get more details ALL OBJECTS shows pictures and text for all items in the exhibit Other Two Parts of the "Secret Life..." Exhibit http://www.metmuseum.org/exhibitions/listings/2016/plant-fibers http://www.metmuseum.org/exhibitions/listings/2017/secret-life-of-textiles-synthetic Peace Silk/No Kill/Cruelty Free - I have not studied this. Feel free to post what you know https://www.treehugger.com/sustainable-fashion/new-silk-production-technique-does-not-require-killing-worms.html http://thekindlife.com/blog/2012/09/alicia-silverstone-what-is-peace-silk/ ~ ~ ~ Continuado - The Minka House at Kew Gardens, England near Richmond, Easy Day trip from London https://sequinsandcherryblossom.com/2013/01/06/silkworms-and-mortice-joints-the-minka-house-at-kew/ 2) Furoshiki Sampling https://www.youtube.com/watch?v=2W0BajFL6uQ Furoshiki: A folded bag https://youtu.be/Z9dbjzcmLBU https://www.youtube.com/watch?v=F74Dwe2BDFw 3) Pensamientos Finales - A Superfluity of Silks - The Alcaiceria, Granada Spain: http://www.andalucia.com/cities/granada/alcaiceria.htm

Paula Cazenave @ Industrial Copera (Granada, Spain) 18-03-2017

Play Episode Listen Later Jun 1, 2017 90:44

Here you can find some techno sets recorded by Paula Cazenave.

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Paula Cazenave @ Industrial Copera (Granada, Spain) 18-03-2017

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Play Episode Listen Later Jun 1, 2017 90:44

Here you can find some techno sets recorded by Paula Cazenave.

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Dreams Highway 180 Guestmix #HouseClassics by NARF ZAYD (GRANADA - SPAIN)

DREAMS HIGHWAY

Play Episode Listen Later May 15, 2017 60:28

DISFRUTA cada semana de un nuevo Radioshow de ‪DREAMS HIGHWAY‬.‬‬‬‬‬‬‬ Sígueme en mis perfiles sociales y Estarás actualizado/a de mis movimientos. ENJOY each week a new DREAMS HIGHWAY Radioshow. Follow me on my social profiles and ENJOY!!. Web http://www.javideejay.net Facebook https://www.facebook.com/djjaviercalvo/ Twitter https://twitter.com/JCALVODeejay Instagram https://www.instagram.com/JCALVODeejay/ Soundcloud https://soundcloud.com/jcalvodeejay/ Hearthis https://hearthis.at/jcalvodeejay/ Mixcloud https://www.mixcloud.com/JCALVODeejay/ iTunes https://itunes.apple.com/es/podcast/dreams-highway/id1041940225?mt=2

You will survive this: A conversation with Rene Ricard

NYC Arts Radio

Play Episode Listen Later Jan 20, 2017 13:38

My conversations with Rene Ricard were many, but this conversation, from early 2013, was the only one we agreed to record for this show focusing on his poetry, paintings, and life at the Chelsea Hotel under new ownership. ---- Mentors are hard to come by; one who takes you in, spends time with you and teaches you something that may one day become useful. Recently, I attended a brilliant show called Fabulous You at Tiger Strikes Asteroid Gallery in Brooklyn. The concept of the exhibition was for the gallery artists to select work from their mentor, or peer, and to exhibit it next to their own. The show reminded me of all I have learned from my mentors and precocious contemporaries over the duration of my own career. We alone have the power to chose our own mentors and bosses, as a surrogate for the examples we want to follow and one day pass on to other eager rookies. This episode is dedicated to those who intend to insight curiosity and cognitive knowledge in others, especially in this unstable chaos of fact vs. fiction and post-truth. Today, I would like to celebrate one of my friends in particular, Rene Ricard. At one time he was my boss, and during that year he became a mentor to me, a commanding influence by imparting his taste, unsurpassed wisdom and opinion of all things. From a life fully lived, he was mercurial, sharp-witted and sharp-tongued, truly informed (he read and read and to absorb concise facts on all historical periods - - he read Museum catalogues from cover to cover, which is an act I now practice and promote). He was an underground Warhol movie star, art critic, painter, and poet. He is credited with launching the career of Basquiat for whom, in 1981, his essay The Radiant Child was published in Artforum. He had no room for BS, but he was generous, and above all - with information, he taught me his first person history of New York and more. Rene enlightened me on the finer details of general world history — mostly through art, including social etiquette and the ways of life over greasy steak and cheese sandwiches he liked to share before starting the days work at his Midtown studio. He brought me along to parties of NYC Painting Gods and Goddesses I had admired since my own teenage move from New England to New York City, like Rene’s own. My friend Rita Barros, whom Rene lived with and is spoken about later in this show, had arranged visiting me in Granada Spain, where I was living between 2011 and 2012; Rita, Antonio, Rosario and Rene made the trip from Lisbon. Rene was unforgettably excited to interact with the art, tromp-l’œil, architecture, food and everything in between. He made an arresting performance for the begging Gypsy’s in front of the Cathedral, where Queen Isabel and King Ferdinand are set in their tombs. If I recall correctly, as my memory will never be what his was, Rene was wearing his recently purchased heeled Flamenco dancing shoes. Back in 2013 after years of dinners and delicious conversations at Rita’s apartment in the Chelsea, we agreed to record one of our conversations in his Chelsea Hotel studio. Rene passed away less than a year later. At the time of the conversation, and unfortunately still today, there was severe discontent in the Hotel. Artists who had been living there for over 40 years were being appallingly harassed by what can only be considered slumlords, trying to drive out the tenants with whatever means possible to free up space in the historic 222 West 23rd Street building. The plan of the new owners was to convert it into a luxury hotel however, some still have the New York fighting spirit. I learned a great number of things from Rene, chiefly to have a fucking opinion and express it with all that you have while being prepared to back it up with authority; facts, and experience. Just listen and absorb….

Ballroom Records Radioshow 090 | Miguel Bastida

Eagle Sessions

Play Episode Listen Later Nov 1, 2016 120:00

Welcome to the Eagle Sessions Episode No. #090 presented by AlBird. Wow 90 episodes already…only 10 more to reach the 100th. What have we got this week? Something new by Miyagi. Delivering his EP ‘7 Days A Week' out on SOSO. Kaiser Souzai's EP ‘The Old Gods', which I already played two tracks of last week is out now on Throne Room Records including remixes by Stanny Abram and Chicago Loop. Austrian fellow Crazy Sonic is back on Tronic with the track ‘Broken Heart' also including a remix of Japanese Duo ‘Drunken Kong' and Also something new by BluFin and my homie Maxime Laffon with his EP Idiote. Guestmix this week is provided again from the guys of Deeperfect and it's my honor to announce Miguel Bastida ahead of their upcoming gig at the Austrian capital Vienna on the 4th of November 2016 at the Eventarena Vösendorf surrounded by other Deeperfect artists like Stefano Noferini, Matt Sassari, and Carlo Ruetz. They're support by the Vienna based locals Joanish and Chris Nait. So if you're around in Vienna, you must not miss this one! Miguel Bastida: Born in Alhama de Granada (Spain) and nowadyas living in Barcelona, is one of the most promising spanish producers. His works on Suara, Sci+Tec, Toolroom, Bedrock, Noir, Trapez, Deeperfect and many more talk for themselves. His creativity, feeling and rhythm in the studio have taken his works to the best clubs and festivals being played by big djs as Richie Hawtin, Dubfire, Paco Osuna. Umek, Luciano, Sebastien Leger or John Aquaviva. https://www.facebook.com/MiguelBastidafanpage/ www.eaglesessions.com Setlist 1st hour: 1. Rauschhaus - Moogadishu (Original Mix) - Steyoyoke 2. Stanny Abram - Kaiser Souzai - The Old Gods (Stanny Abram Remix) – Throne Room Records 3. Maxime Laffon - In My Bedroom - BluFin 4. Affkt, Piek - Esclafit (Paul Ursin Remix) - Sincopat 5. Miyagi - 7 Days a Week (Original Mix) - SOSO 6. Guessbeats, Kidmalone - Daywalker (Original Mix) – Natura Viva 7. Remondini - Borealis (Original Mix) - Egothermia 8. AlBird - Parrot (Original Mix) – Ballroom Records 9. Andrea Martini - Spheres (Original Mix) – Emotive Sounds 10. Ronnie Spiteri - Outlaw (Original Mix) – Leena Music 11. Stefano Noferini, Umberto Pagliaroli - Action (Original Mix) - Deeperfect 12. Oliver Huntemann, Dubfire - Humano (Victor Ruiz Remix) – Senso Sounds 13. Crazy Sonic - Broken Heart (Original Mix) - Tronic 14. Joe Red - Orange (Alberto Ruiz Remix) – BeatFreak Recordings This show is syndicated & distributed exclusively by Syndicast. If you are a radio station interested in airing the show or would like to distribute your podcast / radio show please register here: https://syndicast.co.uk/distribution/registration

Ballroom Records Radioshow 090 | Miguel Bastida

Eagle Sessions

Play Episode Listen Later Nov 1, 2016 120:00

Welcome to the Eagle Sessions Episode No. #090 presented by AlBird. Wow 90 episodes already…only 10 more to reach the 100th. What have we got this week? Something new by Miyagi. Delivering his EP ‘7 Days A Week’ out on SOSO. Kaiser Souzai’s EP ‘The Old Gods’, which I already played two tracks of last week is out now on Throne Room Records including remixes by Stanny Abram and Chicago Loop. Austrian fellow Crazy Sonic is back on Tronic with the track ‘Broken Heart’ also including a remix of Japanese Duo ‘Drunken Kong’ and Also something new by BluFin and my homie Maxime Laffon with his EP Idiote. Guestmix this week is provided again from the guys of Deeperfect and it’s my honor to announce Miguel Bastida ahead of their upcoming gig at the Austrian capital Vienna on the 4th of November 2016 at the Eventarena Vösendorf surrounded by other Deeperfect artists like Stefano Noferini, Matt Sassari, and Carlo Ruetz. They’re support by the Vienna based locals Joanish and Chris Nait. So if you’re around in Vienna, you must not miss this one! Miguel Bastida: Born in Alhama de Granada (Spain) and nowadyas living in Barcelona, is one of the most promising spanish producers. His works on Suara, Sci+Tec, Toolroom, Bedrock, Noir, Trapez, Deeperfect and many more talk for themselves. His creativity, feeling and rhythm in the studio have taken his works to the best clubs and festivals being played by big djs as Richie Hawtin, Dubfire, Paco Osuna. Umek, Luciano, Sebastien Leger or John Aquaviva. https://www.facebook.com/MiguelBastidafanpage/ www.eaglesessions.com Setlist 1st hour: 1. Rauschhaus - Moogadishu (Original Mix) - Steyoyoke 2. Stanny Abram - Kaiser Souzai - The Old Gods (Stanny Abram Remix) – Throne Room Records 3. Maxime Laffon - In My Bedroom - BluFin 4. Affkt, Piek - Esclafit (Paul Ursin Remix) - Sincopat 5. Miyagi - 7 Days a Week (Original Mix) - SOSO 6. Guessbeats, Kidmalone - Daywalker (Original Mix) – Natura Viva 7. Remondini - Borealis (Original Mix) - Egothermia 8. AlBird - Parrot (Original Mix) – Ballroom Records 9. Andrea Martini - Spheres (Original Mix) – Emotive Sounds 10. Ronnie Spiteri - Outlaw (Original Mix) – Leena Music 11. Stefano Noferini, Umberto Pagliaroli - Action (Original Mix) - Deeperfect 12. Oliver Huntemann, Dubfire - Humano (Victor Ruiz Remix) – Senso Sounds 13. Crazy Sonic - Broken Heart (Original Mix) - Tronic 14. Joe Red - Orange (Alberto Ruiz Remix) – BeatFreak Recordings This show is syndicated & distributed exclusively by Syndicast. If you are a radio station interested in airing the show or would like to distribute your podcast / radio show please register here: https://syndicast.co.uk/distribution/registration

BN 034: Insights from my long term Travel destinations (Part 2)

Become Nomad - Digital Nomad Lifestyle and Long Term Travel

Play Episode Listen Later Jul 21, 2016 34:30

A few episodes ago we went through some of the lessons I have learned in my first 5 nomadic destinations. Today we continue the journey with my next destinations, from Granada Spain to Sarajevo in Bosnia. I will introduce some of the changes I made following my stay in those countries, from actual practical to changing my mindset in general. I will discuss how cost of living should influence the location you choose, how some places are just surprisingly perfect while others are disappointing, and the connection of the nomadic life with your home country. For detailed show notes please refer to http://becomenomad.com/insights-first-long-term-travel-destinations/

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My Expat Life in Granada, Spain

Travatical-formerly The Expat Chat

Play Episode Listen Later Jan 6, 2016 38:56

There are two types of expats – those who move to another country but retain their current lifestyle and live very much within an expat community as they had back home. Then there are those for whom moving is a chance to embrace a whole new way of life and effectively become a local. Molly Piccavey is definitely the later. She has spent the last 18 years living in Spain, firstly in Barcelona and now Granada where she is largely welcomed as a local. In this interview Molly shares her experiences of living in Granada, why so many expats move home again and what she feels expats need to consider before moving abroad You can follow her journey and life in Granada at her blog http://piccavey.com What I learned from this interview: Be conscious that moving overseas is not a magic bullet. If you are looking to escape from something then be careful you aren’t taking the problem with you! Molly recommends spending the first period of time in a new culture observing how things are done and adapting to the new lifestyle. You are in someone else’s territory and need to embrace the fact. Be conscious of exchange rates if relying on income from back home. If you can spread your risk by earning some local income this will definitely help Be careful buying property. There is a lot of paperwork to deal with and Molly recommends getting a local helper to ease you through the experience and red tape Spain is a great environment for families as the Wagoners showed. Family culture is important to the Spanish and they embrace it in everything they do.

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Episode 227 IronRadio - Guests Cotter and Nelson Topic Nutrition Science Meeting Granada Spain

Iron Radio

Play Episode Listen Later Sep 21, 2013

In this special presentation of geekery, Dr. L has an on-site chat with Dr. Josh Cotter and Doc Candidate Mike Nelson. Get in on this preview of what's coming down the pipeline in nutrition, including insights from a bodybuilding and strength perspective. The International Congress on Nutrition is the world class Olympic Games of nutrition science, held but once every four years. Topics that get attention include how to best squash inflammation before it gets a hold on you, the chronobiology of eating and strength, genetically personalized nutrition, what happens to the body fat of men vs. women as they diet, gene doping, Spanish foods, and more. ...PS - All the audio backgrounds herein are real, on-sight sounds from the Congressos and surrounding local flavor. Bienvenidos!

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Episode 227 IronRadio - Guests Cotter and Nelson Topic Nutrition Science Meeting Granada Spain

Iron Radio

Play Episode Listen Later Sep 21, 2013

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Episode 227 IronRadio - Guests Cotter and Nelson Topic Nutrition Science Meeting Granada Spain

Iron Radio

Play Episode Listen Later Sep 21, 2013 49:00

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Ignacio Henares, University of Granada, Spain, speaks on Goya

From El Greco to Dali

Play Episode Listen Later Apr 23, 2012 4:37

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Granada, Spain: The Exquisite Alhambra

Play Episode Listen Later Nov 24, 2010 3:55

Granada's dominant sight is the Alhambra, the last and greatest Moorish palace. For two centuries, until 1492, Granada reigned as the capital of a dwindling Moorish empire. As Christian forces pushed the Moors farther and farther south, this palace was the last hurrah of a sophisticated civilization. For more information on the Rick Steves' Europe TV series — including episode descriptions, scripts, participating stations, travel information on destinations and more — visit www.ricksteves.com.

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Granada, Spain: The Exquisite Alhambra