Podcasts about skewing

“What are the levers that I can pull that are going to help me create more value?”Say you want to charge more, be more known, get better testimonials, get more respect from others… the simplest pathway is to expand the value you create for others.Value creation is often thought of as a skillset, but what if how you think about value shifts your potential for creating more of it? Here are some ways I think about creating more value…1. Make Their Vision BiggerWhen I meet with a client for the first time, my gut reaction is often to ask, “Are they thinking too small?”They might say they want to launch in one market, and I'll ask, “What would it look like to launch in five markets this year?”Thinking bigger increases excitement for projects. You want to increase excitement only to the point of slight impossibility so that the discomfort isn't too strong. We're not here to merely make happen what is expected, we're here to help make the unexpected occur. In teams, 2+2 = 4, or 6 or beyond. That is the beauty of working with others.Each person adds new capability, new insight, or possibility. Even if you're an employee, thinking this way can expand the value you bring to whoever you work with. You're not always going to follow through on every huge idea you propose, but at least you're expanding the potential reality you can help create.You want to move beyond assumed value or possibility for how well things can go, and contribute your part to create a greater whole. 2. Multiply Value by OverdeliveringPeople say, “Charge what you're worth.” I say: “Overdeliver on the project significantly beyond what you charge.”Whenever possible, you want to add to the “multiple” of value someone receives when working with you. In an ideal world, customers should get 2x-5x+ of the value that they've paid. Skewing value in the favor of your customer creates an abundance loop. Ask yourself, “How can I overdeliver on this project?” It might be sending your clients extra resources or even something as simple as remembering birthdays and sending a quick message. Some examples…Send monthly progress recaps, highlight new opportunities that weren't previously seen. Offer bonus calls to brainstorm and problem-solve.Connect your customer to people you know who can also help them. Share mini “toolkits” of templates, how-to guides, etc. with clients.3. Stay Focused on Transformative ChangeGreat products create transformative change. They transcend beyond what someone “wants” and explore and expand into what someone needs, dreams of, and has never considered before. If you do only what your customer wants you to do, you are creating products based on a view of the world with limited knowledge. The benefit of expertise and mastery is your ability to see significantly more than others in a particular area or subject. It's hard to say “no” to someone. Doing so, though, create the ability to guide and lead someone through a process that they might not have been able to previously imagine or understand. When you hire a travel agent, you don't want to just tell them what to do and have them book it for you. You want them to think of what you never thought of, make decisions you might not immediately understand, and recommend what you would never find yourself. Steve Jobs knew, simply, that people wanted to buy the latest CD player, and yet he said no so that he could create something much greater with his iPod.Creating more value isn't about just having the skills to do so – it's often understanding what's possible, having and building confidence to deliver, and being willing to explore unknown territories that may feel uncomfortable at first but help you expand what's possible for yourself and others.What mindset helps you stay focused on creating more value for others? Or what have you done as a habit that has helped you?

A weekly phone conversation between fantasy veterans Bob Harris and Matt Waldman is a quick and dirty run-down of NFL players, units, or teams. https://youtu.be/mkBM3pcfyXw Topics: Josh Norris' Skewing of Underdog's ADPs Patrick Mahomes Bo Nix Jordan Love Caleb Williams Dak Prescott CJ Stroud Michael Penix, Jr. Tug Tagovailoa Anthony Richardson Bryce Young Derrick Henry Ashton Jeanty Kenneth Walker Omarion Hampton David Montgomery TreVeyon Henderson Quinshon Judkins James Conner Kaleb Johnson Tony Pollard Rhamondre Stevenson JK Dobbins Brian Thomas Malik Nabers Drake London A.J. Brown Ladd McConkey Tyreek Hill Mike Evans Xavier Worthy Rome Odunze DK Metcalf Jakobi Meyers Ricky Pearsall Now entering its 20th season, learn more about Matt Waldman's RSP  — the most in-depth analysis of offensive skill position players available (QB, RB, WR, and TE). Or if you already know the deal, go ahead and pre-order (you know you want to) for $21.95.  Matt's new RSP Dynasty Rankings and Two-Year Projections Package is available for $24.95 If you're a fantasy GM interested in purchasing past publications for $9.95 each, the 2012-2024 RSPs also have a Post-Draft Add-on that's included at no additional charge.   Best yet, proceeds from sales are set aside for a year-end donation to Darkness to Light to combat the sexual abuse of children.

There was lots of Dickin' around in this episode. We had some quick touches on some shows that didn't fit the wheelhouse for full recaps. We almost got into the truck. Multiple choice questions. Skewing the conversation multiple times. Beer styles and competition categories. Weed water. Re-introducing Elijah to the world. Unintentional sours. Lack of schnapps. Eggnog is a cocktail, right? Olive bars. The most amazing chip review we've ever watched.    Want to hear more about our tangent about olive bars and bread slicing murder machines and going to Outback? Sign up for our Patreon!  https://www.patreon.com/truthbeerpod Hoplark for Hop water and hop teas: https://hoplark.com/ No NFL Deathmatch this week, of course. Post Season Points (pre-Suberb Owl) : Gnome : 2 Marco : 3 Julia : 1 ----- This episode covers the following shows : Half Ass Beer Review - Dick's Potato Chip Review Barstool Perspective - 1/17/25 Blake's Craft Beer Podcast - Ep 47 - Cincy Sours The Weekly Pint - Ep 246 - How'd I Manage to Miss This For So Long? ----- What we drank :  Tired Hands Brewing - Alien Church - NE IPA Brouwerij De Brabandere - Bavik Super Wit - Belgian Wit Troegs - Nugget Nectar - Imperial Amber BC's Brewing Co - Jerry - Amber Ale Masthead Brewing - IPA - IPA Rothaus Pils ----- Episode recorded on 1/28/2025 at our amazing podcast host, Higher Gravity Summit Park! https://highergravitycrafthaus.com/ Disclaimer: The views and opinions expressed by Truth, Beer, and Podsequences are those of the participants alone and do not necessarily reflect the views or opinions of any entities they may represent. ------  Links to everything at http://truthbeerpod.com/ or https://truthbeerpod.podbean.com/ Find us on all the social medias @ TruthBeerPod Email us at TruthBeerPod@gmail.com Subscribe, like, review, and share! Find all of our episodes on your favorite Podcast platform or https://www.youtube.com/@TruthBeerPod ! Buy us a pint!  If you'd like to support the show, you can do by clicking the "One-Time Donation" link at http://truthbeerpod.com ! If you want exclusive content, check out our Patreon!  https://www.patreon.com/TruthBeerPod If you'd like to be a show sponsor or even just a segment sponsor, let us know via email or hit us up on social media! ----- We want you to continue to be around to listen to all of our episodes.  If you're struggling, please reach out to a friend, family member, co-worker, or mental health professional.  If you don't feel comfortable talking to someone you know, please use one of the below resources to talk to someone who wants you around just as much as we do.   Call or Text 988 to reach the Suicide and Crisis Lifeline Chat with someone at 988lifeline.org http://www.988lifeline.org ----- Our Intro, Outro, and most of the "within the episode" music was provided by Gnome Creative. Check out www.GnomeCreative.com for all your audio, video, and imagery needs! @gnome__creative on Instagram @TheGnarlyGnome on Twitter https://thegnarlygnome.com/support http://gnomecreative.com http://instagram.com/gnome__creative http://www.twitter.com/TheGnarlyGnome

Show Notes https://www.rushtoreason.com/show-notes/09-16-2024/

Pags Outlines the New COVID Numbers and How the Media Is Skewing Them for Political Gain—Blaming Trump and Why That's Wrong! Plus, an Interview with Ted Poe on the Big Question: Where the Heck Is Congress? Learn more about your ad choices. Visit megaphone.fm/adchoices

According to the Centers for Disease Control and Prevention (CDC), the maternal mortality rate in the United States is very high compared to other wealthy countries: About 22.3 maternal deaths per 100,000 live births. This is on par with China and Iran, based on UNICEF data.So why is the US maternal mortality rate so high? It may have to do with how we fill out death certificates.A study from earlier this year found that misfiling of information in death certificates may be inflating the numbers. The study authors concluded that the US maternal mortality rate was actually half of the CDC-reported rate—about 10.4 per 100,000 live births—which is in line with countries like Canada and the United Kingdom.But if death certificates can skew maternal mortality statistics by such a huge margin, what else could they be influencing? And how does our system for filling out death certificates work?To answer these questions, guest host Maggie Koerth is joined by Dr. Robert Anderson, chief of the statistical analysis and surveillance branch at National Center for Health Statistics.Transcripts for each segment will be available after the show airs on sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

Episode 2480 - On this Friday's show Vinnie Tortorich welcomes Dr. Zöe Harcombe and they discuss calling out researchers for skewing the numbers for breast cancer screening, HPV, and more. https://vinnietortorich.com/2024/04/skewing-the-numbers-dr-zoe-harcombe-episode-2480 PLEASE SUPPORT OUR SPONSORS   YOU CAN WATCH THIS EPISODE ON YOUTUBE - Skewing the Numbers Dr. Harcome addresses health and wellness claims and debunks them when necessary. (3:00) One of the more recent articles was centered around red meat causing T2 diabetes. Another article claims intermittent fasting will cause cardiac death. (4:15) She shares a recent experience at a conference and addresses intermittent fasting. (7:00) She points out the details and explains how information was gathered. The headline is based on 31 people; however, the starting numbers of the study were significantly higher. This means that the entire study only used 1.5% of the information gathered. The report is then based on skewing the numbers. The next headline has to do with breast cancer screening. (27:00) There are very specific instances where highly extensive treatment may not have been necessary for some women. (33:00) The problem with this is that chemotherapy is toxic as well. Things like having the BRCA1 gene are not included in this, and shouldn't be; that is a different circumstance. HPV discussion: What is the current information about HPV? (39:00) Back to the breast cancer screening, Dr. Harcombe shares more information. (45:00) She shares how she personally approaches screening. They chat a bit about Princess Kate of the British Royal family and her recent hospital stay. (55:00) Belly Reduction Dr. Harcombe touches on a report about kimchi. (1:00:00 ) The claim says it can reduce "beer belly," but the standards of obesity are much different in Korea than they are in the West. A "beer belly" in Korea is a 32" waist. You also need to see who funds the studies—as usual, follow the money. Also, places like Harvard push an agenda; funding doesn't happen unless your study follows the agenda. (1:05:00) The system creates the narrative. (1:06:00) Dr. Harcombe shares what it takes to get research published; it's difficult, especially since her studies tend to go against the narrative. You can find her website at Look for Vinnie's NSNG® VIP Community and sign up for the waitlist! Go to to sign up! [the_ad id="20253"] PURCHASE BEYOND IMPOSSIBLE (2022) The documentary launched on January 11! Order it TODAY! This is Vinnie's third documentary in just over three years. Get it now on Apple TV (iTunes) and/or Amazon Video! Link to the film on Apple TV (iTunes):  Then, Share this link with friends, too! It's also now available on Amazon (the USA only for now)!  Visit my new Documentaries HQ to find my films everywhere: REVIEWS: Please submit your REVIEW after you watch my films. Your positive REVIEW does matter! FAT: A DOCUMENTARY 2 (2021) Visit my new Documentaries HQ to find my films everywhere: Then, please share my fact-based, health-focused documentary series with your friends and family. The more views, the better it ranks, so please watch it again with a new friend! REVIEWS: Please submit your REVIEW after you watch my films. Your positive REVIEW does matter! FAT: A DOCUMENTARY (2019) Visit my new Documentaries HQ to find my films everywhere: Then, please share my fact-based, health-focused documentary series with your friends and family. The more views, the better it ranks, so please watch it again with a new friend! REVIEWS: Please submit your REVIEW after you watch my films. Your positive REVIEW does matter!  

Have you heard this before in your teams: If we removed these students from our schoolwide data, our trends would look better. In this episode, we're tackling the myth that some students' behavior data skew our schoolwide data. Joining us in this conversation are Rayann Silva and Mari Meador from the University of Washington's School Mental Health Assessment Research and Training (SMART) Center. Rayann has done it all in education. From classroom teacher to district administrator, to state/regional school mental health training and technical assistance provider, she centers social-emotional well-being in every role she holds. In her current work, she supports education agencies and school districts to deliver evidence-based strategies that improve social, emotional, and behavioral outcomes for all. As an implementation coach, Mari supports schools in their implementation efforts. She has been a PBIS state facilitator, an assistant coordinator for the Northwest PBIS Network, and a school-based counselor and mental health associate. Mari is a forever advocate for system-level change, culturally responsive practices, and social-emotional learning. Together, we talked about the unintended consequences of excluding some students from schoolwide data, and what it truly means to include every student's experience in our schoolwide decisions. For more information about the resources shared in this episode, check out the following links: Role of social worker at all three tiers from Washington State Association of School Psychologists Behavioral Health Coalition

Andy and Jeff share their thoughts on Kentucky's round one loss to Oakland in the NCAA Men's Basketball tournament and discuss whether or not John Calipari needs to change his coaching and recruiting style. 

Is the officiating in the NBA really that bad? Or are complaining coaches and players skewing the point of view?

Joining me is none other, my own thoughts. Sharing some updates, announcements, and goals for an upcoming new chapter. I also recap the busy month of October, followed by some November plugs, and into the discussion of “lefties”. —————————————————————— We found a house 3:13 . Inviting guests in-studio 4:36 . Tech Utopia exhibit 11:43 . Busy October 18:28 . INKtober 25:18 . 20/30 content challenge 32:34 . October markets 34:46 . The impact of Tech Utopia 51:18 . November plugs 56:14 . People identifying as a noun 1:00:11 . “The Poop Hallway” 1:03:29 . New addiction on YouTube 1:09:26 . Skewing the Eng. language 1:16:02 . A Douglas Murray Quote 1:23:52 —————————————————————— G Terado https://www.instagram.com/artofgterado/ https://www.facebook.com/ArtofGTerado https://www.youtube.com/@artofgterado https://theartofgterado.square.site

One of the more popular courses you could take at my college to fulfill the finance major requirements was Behavioral Finance. The main “textbook” was Inefficient Markets and we learned about how there are qualitative ways to value a security beyond what the efficient market hypothesis purports. During the financial crisis of 2008, psychology professor […] The post Dear Analyst #121: Fabricating and skewing Excel survey data about honesty with behavioral economists Dan Ariely and Francesca Gino appeared first on .

Jesse Reynolds shows how many SRM papers overestimate risks and underestimate benefits. Paper: "Communication of Solar Geoengineering Science: Forms, Examples, and Explanation of Skewing" https://journals.sagepub.com/doi/10.1177/20530196221095569 More papers are at https://jreynolds.org/

U.S. Senator Tommy Tuberville debunks false media coverage and rhetoric from the Biden administration over his military nominations hold over abortion travel policy and vows to continue the fight. The U.S. Senator from Alabama says that with the issue of abortion aside, first and foremost the Biden administration and Department of Justice circumventing Congress and implementing the abortion travel policy, “is against the law.” Congress has never authorized the Pentagon to spend tax dollars to allow people to travel for an abortion, saying, “I campaigned very hard for two years to be elected in the Senate to be able to represent and give the people of Alabama an opportunity to vote on a controversial topic like this. And so you're not gonna go around me, you're gonna have to go through me and it's been interesting, they've come at me from all angles.” The former College Football Coach says he's “been called everything as a coach, but my goodness, I've never been called a terrorist and a communist.” Saying, from the beginning he's expressed his concerns over changing the abortion travel policy “with a memo instead of going through Congress, like they should.” Tuberville says, the media and the Biden administration derive their authorization from the DOJ. “First of all, I wouldn't trust them to give any answer to any question, I've seen how they've acted. “The DOJ, weren't elected, they were appointed. And I was elected and I deserve a right to vote for the people of Alabama on this and so I'm not going to accept that excuse.”See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

JD and Emanuel Datt, founder of Datt Capital, sat down for a broad-ranging 1 on 1 discussion.We went in-depth on Emanuel's investment style, what the current macro environment is looking like, and what his thoughts are on various commodities as well as digging into a few stock-specific thoughts. In addition, we couldn't resist a rapid-fire under-rated vs over-rated round to finish things off. All Money of Mine episodes are for informational purposes only and may contain forward-looking statements that may not eventuate. The co-hosts are not financial advisers and any views expressed are their opinion only. Please do your own research before making any investment decision or alternatively seek advice from a registered financial professional. Thank you to our Podcast Partners:Terra Capital – Specialist Investment manager in the natural resources sectorAnytime Exploration Services – Exploration workers, equipment, core cutting/storage plus much moreJP Search – Recruitment specialists for the financial worldK-Drill – Safe, reliable, and productive surface RC drillingTopdrill – Using digital solutions to provide safe, productive, and cost-effective drilling services Join our exclusive Facebook Group for the Money Miners and request access to the Hooteroo chat group. Subscribe to our weekly newsletter HOOTEROO HERALD Follow Money of Mine on YouTubeFollow Money of Mine on TwitterFollow Money of Mine on LinkedInFollow Money of Mine on Instagram Chapters:(0:00) Preview(0:39) Intro to the interview(4:57) Interview with Emanuel(6:23) Being a Unique & Uncorrelated Fund Manager(12:15) Extracting Value from Twitter(13:40) Getting up the Curve Yourself(16:08) Instinct vs. Intuition(17:14) Not Engaging Management(20:41) Running an Absolute Return Fund(21:45) Being an Activist(24:05) The Macro(25:30) Large Cap vs Small Cap Value Divergence(27:40) Getting compensated for Illiquidity(30:45) Tech vs Resources(34:00) Risks of Holding Coal(36:35) The Rare Earths Outlook(38:52) What to look out for as a WA1 Holder(43:00) Seeing Value in GL1(46:06) Dreadnought's News on the Horizon(47:18) Adriatic inching toward Production(53:56) Over-rated vs. Under-rated!

Podcast Description   So much of what we believe to be true about how we parent our children is skewed by Western, dominant culture. A perfect example of this is potty training, where we're told the day a child turns two years old is when you throw the diapers out. I even did this with my own son! But is this really developmentally appropriate for all children? After working with families for the past 20 years, I strongly believe most of us are better served when we incorporate some of the rituals and traditions that our ancestors and our families of origin carried out. So much has been forgotten or even demonized as something we shouldn't be doing anymore. In this episode, I want to talk about the intersection of culture and parenting and how in many ways, we're making life harder for ourselves by not latching onto our cultural traditions. I want to remind you how reconnecting with family rituals can actually be extremely healthy for you as parents and for your child's development.  You can follow Brandi and her work @deardouapodcast on IG, @brandi_jordan_official IG, and send questions, comments and platitudes to brandi@deardoulapodcast.com. Have a question you want Brandi to answer? Shoot her an email or a DM and she might include it on her next podcast episode! If you are looking for support with your children, you can reach out to us at The Cradle Company for more information on hiring a parenting or baby specialist. If you appreciate Dear Doula, please take a minute to subscribe, rate and review! Time Stamps: 01:11 - We hear how a recent post about potty training inspired Brandi's reflection on how culture influences our parenting choices. 03:53 - Brandi explains what the pandemic showed us about the intersection with culture and parenting. 06:23 - Brandi explores how dominant culture decides what's demonized and what's in fashion through the example of baby wearing. 08:01 - We learn about Brandi's experience of parenting views in Black American culture versus what dominant culture tells us. 09:53 - We find out how reconnecting with cultural traditions teaches us about creating new ages of developmental appropriateness, rather than assuming what dominant culture says is right. 13:30 - Brandi tells us how cultural rituals can give you comfort when you're exhausted from trying to follow constant rules about how to parent. 14:47 - Brandi questions how many of the responsibilities we have are taken on because we think we should be doing it. 17:02 - Brandi encourages us to think back to the family rituals from our childhood that we could incorporate into our own families.  

AI is a great tool for lifting the burden of repeatable, predictable tasks off humans. Until it isn't. The fact is, a lot of AI is biased and even unconsciously discriminatory. It's trained on poor, skewed datasets as the result of traditional biases in the tech industry. That means in the real world,  unrepresented groups such as women are losing out on opportunities as a result of decisions being made by AI in finance, HR, healthcare, and more. So what can we do to solve this issue? We're joined by Professor Anjana Susarla from Michigan State University to find out.This is Technology Now, a weekly show from Hewlett Packard Enterprise. Every week we look at a story that's been making headlines, take a look at the technology behind it, and explain why it matters to organisations and what we can learn from it.We'd love to hear your one minute review of books which have changed your year! Simply record them on your smart device or computer and upload them using this Google form: https://forms.gle/pqsWwFwQtdGCKqED6Do you have a question for the expert? Ask it here using this Google form: https://forms.gle/8vzFNnPa94awARHMAAbout the expert: https://broad.msu.edu/profile/asusarla/Anjana's book recommendation: Algorithms of Oppression: How Search Engines Reinforce Racism

AI is a great tool for lifting the burden of repeatable, predictable tasks off humans. Until it isn't. The fact is, a lot of AI is biased and even unconsciously discriminatory. It's trained on poor, skewed datasets as the result of traditional biases in the tech industry. That means in the real world,  unrepresented groups such as women are losing out on opportunities as a result of decisions being made by AI in finance, HR, healthcare, and more. So what can we do to solve this issue? We're joined by Professor Anjana Susarla from Michigan State University to find out.This is Technology Now, a weekly show from Hewlett Packard Enterprise. Every week we look at a story that's been making headlines, take a look at the technology behind it, and explain why it matters to organisations and what we can learn from it.We'd love to hear your one minute review of books which have changed your year! Simply record them on your smart device or computer and upload them using this Google form: https://forms.gle/pqsWwFwQtdGCKqED6Do you have a question for the expert? Ask it here using this Google form: https://forms.gle/8vzFNnPa94awARHMAAbout the expert: https://broad.msu.edu/profile/asusarla/Anjana's book recommendation: Algorithms of Oppression: How Search Engines Reinforce Racism

AI is a great tool for lifting the burden of repeatable, predictable tasks off humans. Until it isn't. The fact is, a lot of AI is biased and even unconsciously discriminatory. It's trained on poor, skewed datasets as the result of traditional biases in the tech industry. That means in the real world,  unrepresented groups such as women are losing out on opportunities as a result of decisions being made by AI in finance, HR, healthcare, and more. So what can we do to solve this issue? We're joined by Professor Anjana Susarla from Michigan State University to find out.This is Technology Now, a weekly show from Hewlett Packard Enterprise. Every week we look at a story that's been making headlines, take a look at the technology behind it, and explain why it matters to organisations and what we can learn from it.We'd love to hear your one minute review of books which have changed your year! Simply record them on your smart device or computer and upload them using this Google form: https://forms.gle/pqsWwFwQtdGCKqED6Do you have a question for the expert? Ask it here using this Google form: https://forms.gle/8vzFNnPa94awARHMAAbout the expert: https://broad.msu.edu/profile/asusarla/Anjana's book recommendation: Algorithms of Oppression: How Search Engines Reinforce Racism

Try Option Basic Alert for Just $1 https://learn.sharpertrades.com/p/option-alert-trading-signal?coupon_code=BASIC1YTB This week we are going in with the Skewed Iron Condor strategy on GLD (Gold ETF). The reason for choosing this option trade is that GLD volatility has spiked over the last couple weeks as the price has shot way up. As a contrarian, I am going to bet there is more of a chance the price goes down from here then up. So, I will move the Call Side closer to the stock price then the Put Side (Meaning I am "Skewing it downward") to allow that potential downward movement. Hope you enjoy it! Kal ➤ This is a recent trade from our Option Alert System (see link inside). I'll teach you the entire trading process from start to finish. How and why we picked the stock and the strategy. How we set up the trade and how we manage it for success. ➤ If you really want to learn to trade, check out our iron condor option trading course https://www.udemy.com/course/option-trading-for-rookies-advanced-option-strategies-iron-condor/?referralCode=05F82F8D48036DFB3A92 ➤ Sign up to our blog to receive trade ideas and market updates. learn.sharpertrades.com/blog #OptionTrading #TradingOptions #Trading Trading Risk Disclaimer All the information shared in this video is provided for educational purposes only. Any trades placed upon reliance of SharperTrades.com are taken at your own risk for your own account. Past performance is no guarantee. While there is great potential for reward trading stocks, commodities, options and forex, there is also substantial risk of loss. All trading operations involve high risks of losing your entire investment. You must therefore decide your own suitability to trade. Trading results can never be guaranteed. This is not an offer to buy or sell stocks, forex, futures, options, commodity interests or any other trading security.

 Benefit from the great wealth transfer and learn about the great lack in financial literacy. Our guest today is the educating leader at OptionsPlay and an advocate for financial literacy. She has over 13 years of experience in the financial industry and specializes in options trading.Jessica Inskip is passionate about teaching financial literacy to the next generation of investors. She has spent her career bouncing between brokerage firms, eventually taking a job at OptionsPlay, where she is free to create educational content. She saw the influx of meme traders and new investors in the stock market, and wanted to ensure that they have access to the right information. To do this, she has created courses, web portals, and social media content, teaching the basics of options trading and the importance of financial literacy. Jessica wants everyone to understand the stock market, and to make sure they have the right tools to protect their investments. In this episode of How To Trade It, Casey & Jessica discuss the new influx of meme traders, risk tolerance, the different types of investor in the stock market, and so much more. You don't want to miss it!Subscribe to How To Trade ItYou'll want to listen to this episode, if you are interested in hearing Jessica Inskip discuss… 00:01:00 - Becoming involved in the financial business00:02:24 - From client to vendor at OptionsPlay00:04:39 - Meme trading and valuation00:06:15 - Skewing risk versus reward in your favor00:09:40 - The great wealth transfer00:16:09 - Financial literacy00:18:23 - Be agile and learn yourself00:21:40 - The goal of OptionsPlay00:23:18 - How automatic trading operates00:30:04 - Get connected with JessicaResources & People Mentioned: Tony Zhang - LinkedinMerillOCCDeloitteTom Sosnoff - TastyliveGameStopAppleRick Bensignor - LinkedinMorgan StanleyConnect With Jessica Inskip:  Website:      https://www.optionsplay.com/Twitter:         https://twitter.com/JessInskip_TikTok            https://www.tiktok.com/@jessicainiskipInstagram:   https://www.instagram.com/jessinskip_Podcast:        Market Playbook PodcastSupport the showConnect with Casey: LinkedIn: https://www.linkedin.com/in/caseystubbs Twitter: https://twitter.com/caseystubbs316 TradingStrategyGuides.com: https://www.tradingstrategyguides.com/ Email: info@tradingstrategyguides.com

Joel Salatin from Polyface farms joins me on Zoom to talk about some of the problems in ag, and how things could look in the future. Polyface Farms website --------------------- Buy BoBoLinks Here! One Earth Health Beef organ pills! RedHillsRancher.com My Patreon My Linktree --- Send in a voice message: https://anchor.fm/ranching-reboot/message Support this podcast: https://anchor.fm/ranching-reboot/support

Welcome to Friday 15! In episode 88 Steph chats about if experienced advisors were more likely to take the HAR survey, host with one booking system, and can new TA's get $100,000 in gross sales. 00:00 | Welcome and meet Steph! 01:27 | Do more experienced advisors take HAR's survey? 06:58 | Are there hosts with one portal to book all suppliers? 11:45 | How hard is it get $100,000 in sales as a newbie? Watch as a video: https://www.youtube.com/watch?v=hECh6KK_SsE (Lots of visuals this episode!) A list of helpful resources for today's episode: https://hostagencyreviews.com/blog/hosted-travel-advisor-income-fee-report-2022 (The report that will answer all your questions!) https://hostagencyreviews.com/blog/tagged/travel-agent-surveys (History of our survey results) https://hostagencyreviews.com/blog/travel-preferred-supplier (What is a preferred supplier) https://iwantacruise.com/advanced-travel-search/ (Odysseus booking platform used by Outside Agents) https://hostagencyreviews.com/blog/host-agency-commission-plan-comparison-calculator (Commission plan calculator) Submit your burning question here: https://har.news/Friday15 and join us this Friday (and every Friday!) at 12CT for travel agent tips!

Ad fraud may not be top of mind, but if you're ignoring fraudulent clicks on your website and campaigns you could be in for trouble. In this episode we sat down with Lucas Rabinowitz, Sr. Director of Growth Sales, from Cheq and ClickCease to find out more about this growing and dangerous trend and how you can protect your organization (and budget).

I am so glad to welcome Manjit once again to our podcast! This is an amazing episode where you will learn a lot about the flipping master himself. Manjit has raised over 40 million dollars in capital since he started 14 years ago in the business. Just imagine that level of expertise. You won't want to miss it!In this episode, we cover:Manjit has flipped over 130 properties throughout his career. When he first got started, he had the classical snowball effect where he got a couple of scarse deals at the beginning, and then deal after deal!He got started in 2008 at 23 years old. He began his way into the business through rentals.No matter how slow the market is, if you start at a good price point, and you have a good product, you're gonna sell!Skewing numbers when flipping. He had a great amount of luck with referrals, and has been using the same crew for over 6 years. His secret? Finding the right people at the beginning.When dealing with contractors, pay them on time. Contractors can be so loyal and go above and beyond if you take them seriously and pay them first. The best part? There is much more work for them in the future! Because they don't have to waste time with other people, and therefore dedicate their job to you.PRO TIP: refine numbers when you're starting out. Check out other people's business models.About Manjit Rukhra:Manjit is a real estate entrepreneur from Winnipeg, Manitoba. He quit his job as a correctional officer and started a successful real estate investing company. He has personally invested in over a hundred properties using none of his own money.Manjit helps new and active real estate investors start and grow their own real estate investing businesses. He advises them on various sources of capital that may be needed to buy properties and how to profitably buy rentals, flip houses, and wholesale residential real estate. Manjit's clients have been able to utilize his systems and support to quit their day jobs, earn 6+ figure income, build passive income and create long-term wealth. Connect with Manjit Rukhra:Website: https://www.prosperpath.com/Instagram: https://www.instagram.com/manjit_rukhra / https://www.instagram.com/prosper.path Book a call: https://www.prosperpath.com/schedule  Connect with Danielle Chiasson:Website: https://letsgetrealestatepodcast.com/LinkedIn: https://www.linkedin.com/in/daniellechiasson/Facebook: https://www.facebook.com/DaniChiassonInstagram: https://www.instagram.com/letsgetrealTikTok: https://www.tiktok.com/@danichiassonBook in a call: https://calendly.com/strategicsuccess/lets-get-real-estate-20-min-chat Listen in and subscribe for more.You can also leave us a review and of course, don't forget to share. I'm sure there are real people in your network who can take advantage of what they're going to learn from the show. 

OUTWEIGH: Licensed Paramedical Aesthetician Hannah Ellis is our expert guest in this 3-week series with Amy. In episode 2 of 3 they talk about how common IG/TikTok Filters are used and how it skews our views of what real/healthy skin should look like - i.e. what even is healthy skin in general?     Hannah Ellis is a Licensed Paramedical Aesthetician and founder of Hannah Ellis Skincare here in Nashville, TN.    As a Paramedical Aesthetician, her approach to skin starts internally and works its way to the surface by changing the way your skin functions at a cellular level via truly nourishing the skin without ablative and harsh treatments but strategically thoughtful and custom treatments for every skin condition. Hannah and her team of expert aestheticians she has trained specialize in acne, melasma and pigmentation issues, rosacea, aging concerns, and so much more all with a holistic approach through skin changing treatments, custom complexion home care routines and detailed education their clients can't find anywhere else. Her motto is “I empower my clients to achieve the healthiest skin of their life."   Hannah Ellis  Owner | Hannah Ellis Skincare  @thenashvilleaesthetician hannahellisskincare.com   To contact Amy about Outweigh: hello@outweighpodcast.com Best places to find more about Amy: RadioAmy.com + @RadioAmySee omnystudio.com/listener for privacy information.

OUTWEIGH: Licensed Paramedical Aesthetician Hannah Ellis is our expert guest in this 3-week series with Amy. In episode 2 of 3 they talk about how common IG/TikTok Filters are used and how it skews our views of what real/healthy skin should look like - i.e. what even is healthy skin in general?     Hannah Ellis is a Licensed Paramedical Aesthetician and founder of Hannah Ellis Skincare here in Nashville, TN.    As a Paramedical Aesthetician, her approach to skin starts internally and works its way to the surface by changing the way your skin functions at a cellular level via truly nourishing the skin without ablative and harsh treatments but strategically thoughtful and custom treatments for every skin condition. Hannah and her team of expert aestheticians she has trained specialize in acne, melasma and pigmentation issues, rosacea, aging concerns, and so much more all with a holistic approach through skin changing treatments, custom complexion home care routines and detailed education their clients can't find anywhere else. Her motto is “I empower my clients to achieve the healthiest skin of their life."   Hannah Ellis  Owner | Hannah Ellis Skincare  @thenashvilleaesthetician hannahellisskincare.com   To contact Amy about Outweigh: hello@outweighpodcast.com Best places to find more about Amy: RadioAmy.com + @RadioAmySee omnystudio.com/listener for privacy information.

On the 336th Anfield Index Podcast, Trev Downey, Lisa Marie Hanahan and Karl Coppack look back on the week that was for LFC, discuss the various areas of concern and revel in the reasons to be cheerful ahead of the clash with Manchester United.Prefer to listen to our shows without the ads? We've got your back, just head on over to http://anfieldindexpro.com and supercharge your listening experience.Chat and debate 24/7 with other Reds, join our FREE Discord community at https://bit.ly/3geu605Follow us on Twitter: https://bit.ly/3u9gYShFind us on Facebook: https://bit.ly/3KWFxbdSubscribe on YouTube: https://bit.ly/3KXImsjFREE iOS app: https://apple.co/3KSqdMGFREE Android app: https://bit.ly/32KMxqmSupport this show http://supporter.acast.com/theanfieldindex. Our GDPR privacy policy was updated on August 8, 2022. Visit acast.com/privacy for more information.

Join me to learn how the increase in demand for new construction has affected the recent market data. Connect with Me! 941-256-3321 Info@MattLeicht.com Instagram: https://www.instagram.com/mattleichtrealtor Facebook: https://www.facebook.com/mattleichtrealtor Pinterest: https://www.pinterest.com/mattleicht/ Website: https://www.mattleicht.com/

Brad, Matt, and Aaron are all here for this week's episode of Shift And Steer. This week the guys talk NASCAR, SUPRA getting a Manual & the Long Beach Grand Prix.THANKS FOR SUPPORTING OUR SPONSORS: GEICO: Visit Geico.com

Former McDonald's CMO Jenni Dill joined the old but iconic Arnott's in the same role 18 months ago after US private equity firm KKR paid $3.2 billion for the business from Campbell's. Rather than stripping out costs in pursuit of rapid profit, the new owners are investing to build Arnott's return as a contemporary Australian iconic brand. The growth plans are ambitious and, in the case of a sell-out of Tim Tam perfume, unconventional – but this year will see Dill and her team put the foot down an accelerate an all new Arnott's. A booming retailer media sector, by the way, is promising for Arnott's growth but Dill remains pragmatic on its potential. For now, it's sitting at circa 10 per cent of the biscuit maker's budget.  See omnystudio.com/listener for privacy information.

In this episode, Molly discusses the need for grassroots action to support and encourage Republican state lawmakers to draw maps that favor pro-America Republicans, plus a brief discussion about the Joe Rogan/Spotify controversy and questions from the mailbag.

It's the most noggiest time of the year. Engineer porn. SF don't like BRC. Check your dick to own the libs. Thank yous to guest and patron, Neko. December 2022. A swing and a what. Skewing male. Derp red pill. It has a playa. Blurred lines. In your shit: glutamate. WHAT WE'VE BEEN WATCHING: It's Always Sunny in Philadelphia, Veep, Noah vs Mother!, Oakie Noodling.   #BrokenPeopleDontChange #LASDgangs #Antinatalism WHAT WE ARE LISTENING TO: Citations Needed: https://citationsneeded.libsyn.com/ Eat the Rich: https://soundcloud.com/eattherichpod TRASHFUTURE: https://trashfuturepodcast.podbean.com/ Strong Songs: https://strongsongspodcast.com/ Story Shed: https://app.kidslisten.org/pod/Story-Shed Qanon Anonymous : https://www.qanonanonymous.com/ Knowledge Fight: https://knowledgefight.com/ Maintenance Phase: http://maintenancephase.com/ You're Wrong About: https://yourewrongabout.com/ On the Media: https://www.wnycstudios.org/podcasts/otm Music: "Burning Man 2015 - Sleazy Beaches (Bass Set)" by Escher Beat https://soundcloud.com/escherbeat

As the Omicron variant continues to pose a growing threat around the world, the Morning Show with Guest Host Chris Merrill says COVID non-believers are finding creative ways to make their alternative facts heard. See omnystudio.com/listener for privacy information.

Elon bought a decent sized fixer upper practice. Skewing on the older side of dental school graduates, Elon has masterfully married his clinical skillset with the needs of this patient base. Is Elon going the direction of super solo practice, or can he squeeze a group practice into 5 operatories?

The Department of Defense isn't sharing vaccination data by locality. That makes military-heavy areas like Hampton Roads look like they're lagging far behind in vaccination rates when they may not be.

It is a blessing and a curse. Being in a position of management or any type of authority means you likely can see when things are wrong or don't quite fit the ideal. That is a valuable skill set that is worth cultivating. As a result we tend to skew negative and become primarily focused on what is wrong which inevitably leads to an anemic and rather bleak outlook in the coffee shop.  Today on Shift Break we will be talking about how we can balance our natural tendencies with mindsets and actions that skew positive.    Related episodes: The Affirmation Vacuum Are you Excited?   Bridging the Values-Actions Gap   Visit our sponsors! Elevated batch brew and so much more! Ground Control Cyclops Brewer   The best espresso machines in the world! www.lamarzoccousa.com  

This episode is also available as a blog post: http://donnyferguson.com/2021/06/28/biden-administration-skewing-carbon-numbers-to-push-regulations/ --- Send in a voice message: https://anchor.fm/donny-ferguson/message

Paul and Brendan break down the Orioles' recent bullpen struggles, Dean Kremer's demotion and Austin Hays' injury.

Skewing away from ghosts for a few minutes. Daniel jumps into the “other paranormal”… aliens. Disclaimer, not a scientist. He approaches the idea from a spiritual look, mixed with a few science concepts. Then right back to ghosts with the UFO Sighting capital of Canada, Dundas. Featuring one of the oldest hotel buildings in Ontario. --- Over 20 years in the Paranormal! Daniel's unique experience as a paranormal investigator and ghost tour guide allow for interesting tales. This channel and related podcast are dedicated to the real ghost story. Tales gathered over the years. Authentic stories from regular people. And so many personal accounts to tell. These raw, unedited and spooky discussions are bound to make believers. New Shows every Wednesday! contact email... ggdaniel@ghostwalks.com Listen to Latest Podcast on Anchor... https://bit.ly/39BLnym Daniel's Work... https://ghostwalks.com/ find me on facebook... Ghost Guide Daniel

Why are you a dentist? What do you WANT to do in your practice? Consider the fact that YOUR practice belongs to YOU! How you run your practice is up to YOU. You do not have to be a pawn in the game that belongs to the big insurance companies anymore. Today's guest is Dr. Nicole Vane, and she shares her story of how she has forged ahead in her practice to create a new way of managing her practice so she is the person in charge. Her experience will help open your eyes so you can look at yourself and your practice in a new way. We can get dentistry back to where we want it to be… but we have to work TOGETHER! Have you been churning out the work in a fast-paced, high-producing practice that is heavy in PPO billing? If so, there are other business models you can incorporate to boost your profits without running yourself into the ground. You can break the cycle of a business model that does not serve you anymore. Say “Yes” to yourself and to your practice by saying “No” to being controlled by the insurance companies that set the rules for how you bill and the fraction of payment that you receive for your quality work. This is the time to make a change. Believe in yourself and your ability to break the mold of how you've been managing your practice. You can get back to focusing on the care of your patients: treating your patients with attention and providing the best services for them, not spending all of your time and energy dealing and negotiating with insurance companies. Covering topics such as stepping outside your comfort zone, changing how you think about your practice, framing how you look at your work, aligning the culture in your practice, leading your employees appropriately, and building value and trust with your clients, this episode will open your eyes so you can look at your practice more objectively and focus on your patients… while increasing the ROI of your procedures. Listen to this episode to learn how you can continue to do your best work but also change your mindset to recognize that YOUR work is valued! Highlights from this episode: Shifting dentistry to fee-for-service How thoughts become beliefs and influence how you run your practice Skewing diagnoses based on what the insurance companies dictate Escaping the trapped feeling of catering to the insurance companies Comparing courage versus comfort Breaking through the money scarcity mindset Realigning the culture in your practice to change the mindset to work within a new management framework Becoming the leader you need to be Learning to question your objectives and goals Recognizing the trust your patients place in you and value building with clients Looking at production and collection totals and lower costs within the new business model Resources and links mentioned: Dr. Nicole Vane's email: Drnicolevane@yahoo.com Dr. Nicole Vane's trifold: email Laura for a photo of her trifold. drlauramachdds@gmail.com Laura's email: DrLauraMachDDS@gmail.com Laura's website: LoveYourPractice.net Laura's podcast: Love Your Practice! Laura's Facebook pages: Leadership Coach for Busy Dentists Love Your Practice Laura's personal page Thank you so much for tuning in to this podcast! I would love it if you would share it with others and leave a review for others to see! ~ Laura

Why are you a dentist? What do you WANT to do in your practice? Consider the fact that YOUR practice belongs to YOU! How you run your practice is up to YOU. You do not have to be a pawn in the game that belongs to the big insurance companies anymore. Today’s guest is Dr. Nicole Vane, and she shares her story of how she has forged ahead in her practice to create a new way of managing her practice so she is the person in charge. Her experience will help open your eyes so you can look at yourself and your practice in a new way. We can get dentistry back to where we want it to be… but we have to work TOGETHER! Have you been churning out the work in a fast-paced, high-producing practice that is heavy in PPO billing? If so, there are other business models you can incorporate to boost your profits without running yourself into the ground. You can break the cycle of a business model that does not serve you anymore.  Say “Yes” to yourself and to your practice by saying “No” to being controlled by the insurance companies that set the rules for how you bill and the fraction of payment that you receive for your quality work. This is the time to make a change. Believe in yourself and your ability to break the mold of how you’ve been managing your practice. You can get back to focusing on the care of your patients: treating your patients with attention and providing the best services for them, not spending all of your time and energy dealing and negotiating with insurance companies. Covering topics such as stepping outside your comfort zone, changing how you think about your practice, framing how you look at your work, aligning the culture in your practice, leading your employees appropriately, and building value and trust with your clients, this episode will open your eyes so you can look at your practice more objectively and focus on your patients… while increasing the ROI of your procedures. Listen to this episode to learn how you can continue to do your best work but also change your mindset to recognize that YOUR work is valued! Highlights from this episode: Shifting dentistry to fee-for-service How thoughts become beliefs and influence how you run your practice Skewing diagnoses based on what the insurance companies dictate Escaping the trapped feeling of catering to the insurance companies Comparing courage versus comfort Breaking through the money scarcity mindset Realigning the culture in your practice to change the mindset to work within a new management framework Becoming the leader you need to be Learning to question your objectives and goals Recognizing the trust your patients place in you and value building with clients Looking at production and collection totals and lower costs within the new business model   Resources and links mentioned:  Dr. Nicole Vane’s email:  Drnicolevane@yahoo.com Dr. Nicole Vane’s trifold: email Laura for a photo of her trifold. drlauramachdds@gmail.com Laura’s email: DrLauraMachDDS@gmail.com Laura’s website: LoveYourPractice.net Laura’s podcast: Love Your Practice! Laura’s Facebook pages:    Leadership Coach for Busy Dentists    Love Your Practice     Laura’s personal page   Thank you so much for tuning in to this podcast! I would love it if you would share it with others and leave a review for others to see! ~ Laura  

One of the most neglected areas of the bar happens to also be the most important. The register. Not because it is where we handle money (although that is important) but because it is where we make first impressions and guide the experience of both the customer and our coworkers. The register controls everything but we treat this station as though it is simply a place to avoid when on shift or a place to hastily put new underprepared baristas. If we hope to win people over to specialty coffee and deliver a great experience then we need to start focusing at least equal amounts of energy on how we prepare ourselves and others to working this station with the respect it deserves.  Today we are going to be discussing behaviors and habits that are core to creating an excellent service and work experience beginning at the cash register. We cover:  The status quo for register work How the register steals the experience  Skewing positive Urgency Being detailed Communication Warmth and Empathy Related Episodes: 122 : How to be a Cash Register Hero : 6 Essential Skills Episode 45: Simple. Powerful. Hospitality. w/ Philip Paul Turner  Shifting the Shadow Shift 167 : Handing off the Shift : 4 Tips to Avoid Chaos   The BEST in commercial coffee equipment! www.prima-coffee.com/keys   Want the best plant based beverage for your coffee drinks? www.pacificfoods.com/food-service  

Hyped up on the heroic energy of coming to the defense of Kirstie Alley, the team get into it about worshiping big heads, BLM signs covered in razor blades, proof that our devices are listening to us, the horniest social media algorithm, and so much more hilarity.  Patreon.com/TwoJackedBrosIntro and Outro music by Circadian Clock: https://open.spotify.com/artist/5nfGpTvDUwfZzo7IR3LF9wTwo Jacked Bros YouTube Page: https://www.youtube.com/channel/UCTaurCHNJdHrwPmPl_DxUogApple Podcasts/iTunes: https://podcasts.apple.com/us/podcast/two-jacked-bros/id1265973823Spotify: https://open.spotify.com/show/7Jp1uzPsq9KTSQaAF0siUj?si=D0e5ESV2Tsiz1U5fLrdjbwStitcher: https://www.stitcher.com/podcast/sidney-gantt/two-jacked-brosPodbean: https://twojackedbros.podbean.com/Castbox: https://castbox.fm/channel/Two-Jacked-Bros-id1355213?country=usLaughable: https://laughable.app.link/nt37r15FZ4Overcast: https://overcast.fm/itunes1265973823/two-jacked-brosPodcast App: https://podcast.app/two-jacked-bros-p360552/iHeart Radio: https://www.iheart.com/podcast/256-two-jacked-bros-43059654/Google Play/Podcasts: https://podcasts.google.com/?feed=aHR0cHM6Ly9zMy5hbWF6b25hd3MuY29tL2ZlZWQucG9kYmVhbi5jb20veDZrRDlVN2d1cG8vZmVlZC54bWw%3D Two Jacked Bros social media:Instagram: https://www.instagram.com/twojackedbrosTwitter: https://twitter.com/TwoJackedBrosFacebook: https://www.facebook.com/groups/955338234811683/Sidney social media:Instagram: https://www.instagram.com/sidneyganttTwitter: https://twitter.com/sidneygantt?lang=enFacebook: https://www.facebook.com/SidneyGanttAnsley is currently playing social media coy but she can be found through being tagged in things

You don't have to come up with "the next big thing" to have a successful side project. You just need to improve or do something slightly different that what other products or services are already doing. In this episode I discuss a Windows app I had built called Sensible Backup. It is the first side hustle where I actually looked at something I used a lot and really liked, but thought I could improve upon.

Sydney's property market could be in worse shape than it would seem on the surface with sellers withholding or delaying "bad" sales and results. Experts have calculated that approximately 60% of auction results were made public in the last two months, down 20% since this time last year. CEO of McCarthy Property Consultants, Warren McCarthy, joins John Stanley to discuss the declining disclosure of sales data, auction clearance rates and developments to the first home buyers scheme. See omnystudio.com/listener for privacy information.

Dispatches from our final hours with our home for the last week — a boat!

Host: Charles Turck, PharmD, BCPS, BCCCP Now that we're several months into the pandemic, many states and counties are turning to the local data gathered on COVID-19 incidence to help inform their plans moving forward. But are those reports really the most accurate sources of information? To find out, Dr. Charles Turck is here to discuss a recent report discussing how disparities in access to COVID-19 testing sites may be skewing case estimates. Published August, 19 2020

My friend Chauncey tells me about the current pandemic's effect on breweries in Florida and how unfair regulations are crippling the homegrown industry while allowing exemptions and unfair treatment for restaurants. This is a long one but Chauncey breaks down the industry, the laws surrounding it and the situation in such a fantastic way. Easily one of my favorite episodes yet! If you want to support his brewery check out https://hourglassbrewing.com/Stay up to date on the situation and all things brewing at http://www.floridabrewersguild.org/Follow Tindel's Razor on social media, watch on YouTube and listen wherever you find podcasts! https://www.facebook.com/tindelsrazorhttps://twitter.com/TheTindelhttps://www.buzzsprout.com/926959https://www.youtube.com/channel/UCPd7Mc5j0wpHqAVI8V8FoLg?view_as=subscriberhttps://open.spotify.com/show/1gXMJacyrMQPnzt4ZWjhlFhttps://www.stitcher.com/podcast/tindels-razorhttps://castbox.fm/channel/id2795277?utm_campaign=ex_share_ch&utm_medium=exlink&country=usPlease like, share and review whenever you can, it's really helps me continue having conversations that cut through the noise. Stay safe, stay healthy and stay well everyone. 

In this episode, Danny addresses questions he’s been asked frequently over the past couple of months when it comes to fitness. We talk about how to build up your brand, drama in the scientific side of the fitness world, and much more! We even discuss home workout techniques and some of Danny’s favorite ways to meal prep!Thanks For Listening!---RESOURCES/COACHING:I am all about education and that is not limited to this podcast! Feel free to grab a FREE guide (Nutrition, Training, Macros, Etc!) HERE!Interested in Working With Coach Danny and His One-On-One Coaching Team? Click HERE!Want To Have YOUR Question Answered On an Upcoming Episode of DYNAMIC DIALOGUE? You Can Submit It HERE!Want to Support The Podcast AND Get in Better Shape? Grab a Program HERE!----SOCIAL LINKS:Follow Coach Danny on INSTAGRAMFollow Coach Danny on TwitterFollow Coach Danny on FacebookGet More In-Depth Articles Written By Yours’ Truly HERE!-----TIMESTAMPS:Tips to ACTUALLY make fitness your career! Got to give more than you get! 1:49Why having a super-specific niche might hurt you in the long run! 10:31Certifications AKA alphabet soup, IF you don’t use them! 14:47Effective workouts in less time! 10-minute AMRAPS! 17:59Favorite ways to meal prep! It won’t taste like crap! 22:33“Drama” in the research industry! Skewing data? Squats vs hip thrusts for glute growth? 28:20

If the obsession is always monetary, the fulfillment will never come. Why? When you're optimizing for something that, if not managed properly, can be a big stress and distraction, you won't get the feeling of fulfillment which serves as a larger measuring stick for success. We hear it time and again from industry leaders. We learn from their experience that when they finally achieved the number they thought would change their life, that their life hadn't really changed the way they thought. Don't misunderstand, money is not evil, and, as a business, there needs to be a healthy focus on it. If it's all your obsessed about, then you might find it becomes a hindrance to your overall organizational progress.

If the obsession is always monetary, the fulfillment will never come. Why? When you're optimizing for something that, if not managed properly, can be a big stress and distraction, you won't get the feeling of fulfillment which serves as a larger measuring stick for success. We hear it time and again from industry leaders. We learn from their experience that when they finally achieved the number they thought would change their life, that their life hadn't really changed the way they thought. Don't misunderstand, money is not evil, and, as a business, there needs to be a healthy focus on it. If it's all your obsessed about, then you might find it becomes a hindrance to your overall organizational progress.

Good Friday for exposing lies. Tyrants are showing themselves. To whose advantage is the Corona operation? The DS Dims are fighting back. Massive ownership positions showing for the Chinese and cartels. Dump truck mass burials in NYC? Skewing the numbers for profit. Epstein's visitors include who? We can see things so clearly now. Learn more about your ad choices. Visit megaphone.fm/adchoices

On today's show, we open a 6-pack of NBA items, as the All Star Break approaches. How is load management impacting which teams we think are good? Are the Bucks destined for 70 wins (or more...)? Stop doubting the Toronto Raptors!!! The Eastern Conference is going to be a dog fight for seeds 2 through 6. And of course, Zion. Then, we wrap up with a Dads Only with Champ.

This is a powerful, potent and problematic podcast. A CMO, a creative and a publisher talk frankly to Mi3’s Executive Editor Paul McIntyre on the raging bias of ageism in marketing, agencies and media. It’s crippling the marketing industry’s ability to connect with 2 million high-spending, defiant, culturally connected, tech-savvy 50-65 year-old women. Few get it.

  In the immortal words of Jack Nicholson, can you handle the truth? We think you can, and we’re excited to start a new series that dives into the murky world of truth-telling in our culture today: For the Love of Finding the Truth! Skewing the truth is nothing new—bias exists everywhere—but in the pre-social media era, it was a smidge easier to parse through what was real and what wasn’t. With the massive growth of online communities, there are more ways to get information than ever before—and more organizations looking to feed the information they want us to have (#fakenews). Kicking off the series are two women dedicated to sifting through the mountains of information hurled at us each day and understanding it from differing perspectives. Sarah Stewart Holland and Beth Silvers (who go by “Sarah from the left” and “Beth from the right”) stand a few feet from each other on the political spectrum, but are still friends—good friends. And they’re leading the way on how to have grace-filled political conversations, which they do each week on their highly acclaimed podcast Pantsuit Politics. Lucky for us, they wrote a whole book called I Think You’re Wrong (But I’m Listening) to remind us that relationship is always more important than being right. Plus, Sarah and Beth answer some burning political questions like: how does the Electoral College work and why is everyone in a twist about it? Gerrymandering—why should I care? And what’s gonna happen in 2020?? The Pantsuit ladies break it all down and give us thoughtful explanations and opinions, showing us how truth can be revealed through knowledge wherever you stand.

USDA and the the White House this week unveiled version 2.0 of a tariff aid plan, opting for a single, unified payment for all Title I crops instead of last year's per-bushel, per crop payment. Will the new framework avoid altering planting intentions? Pro Farmer Washington analyst Jim Wiesemeyer, AgWeb.com policy writer Anna-Lisa Laca and Farm Journal News Director John Herath analyze details of the new Market Facilitation Program in this week's DC Signal to Noise podcast. They also look at what the new MFP means for the future of China trade talks. See omnystudio.com/listener for privacy information.

4 Degrees Celsius by Leon Rosselson, Extinction Rebellion, Earth Strike, Bernie’s Millions, Dow Buys the EPA, The Case Against Julian Assange, Fighting the Assange Smears, Skewing the Social Security Story, Enfranchising Convicts, Rotting on Remand by Billy Bragg #BernieSanders Bernie-2020.com Twitch.tv/unrelatedthings

So many of you have emailed and asked us questions regarding brunch weddings. Timelines, logistics, menu, layout, micro-events...pros, cons, lessons learned. We're sharing it all with you in this episode, including some incredibly detailed insight from a recent ‘brunch bride' listener. Her post-wedding-day notes are a great retrospective about all things brunch. Let's get ourselves a bloody mary and dive in! Click HERE to become a premium subscriber and unlock all of the amazingness:       Ad-free, full length episodes      The TBWPP Wedding Planning Resource Center with  Access to 6 mini courses of The Big Wedding Planning Master Class  Wedding Planning Templates and Tools Big Takeaways Let's talk about the easy part first: Food and Drinks. Early lunch, or full brunch. Everyone loves a boozy brunch! Carving station, omelettes, frittatas, quiche, breakfast foods, fresh fruits and veg and cheese, sweet treats like pastries and donuts, smoked salmon, small bites, chicken and waffles, limited bar - people still drink beer and wine. Spiked hot drinks, bloodies, mimosas - all sorts! Champagne and coffee are a must. An espresso bar? Yes Please. Timeline example: (Be ready for an early morning!) o 6am-8am, makeup and hair (makeup for 4 people, hair for 1) o 8am-9am, get dressed + getting ready photos with photographer o 9am-10am, First Look, Wedding Party, and ½ of family photos o 11am-11:30am, Ceremony o 11:30am-12:30pm, Cocktail Reception (ceremony room flipped) o 12:30pm-4:00pm, Reception Challenges of a brunch wedding: Skewing things early, and making sure everyone's expectations are in line with the earlier day you have planned - your wedding party, VIPs and guests. Keeping things flowing during the reception - do people dance? Will people stay until the end or cut out early? Apparel Hair and Makeup Light! Small wedding parties and live musicians are perfect for brunch. We see those two things in almost every brunch wedding we've planned or been to as a guest or ‘friendor.' Our Brunch Bride's hindsight: · How we saved money on food and the venue. · It's well suited for a Sunday. If an evening wedding was a priority for us, I would have chosen a Friday or Saturday. But Sunday meant that people in NorCal did not have to take off work, which they appreciated. · Creativity! I enjoy evening weddings where there's a fancy dinner, starry skies, and a lot of dancing. But brunch forced us to reimagine many aspects of our wedding, especially décor and music. · A perk of a Sunday wedding: we got our first picks for vendors. We had a 10-month timeframe and although people were already booked on the Saturday, 10/6, they were free on Sunday, 10/7 to help us. Get In Touch:  The Big Wedding Planning Podcast is…  Hosted and produced by Michelle Martinez  Music by Steph Altman of Mophonics  On Instagram @thebigweddingplanningpodcast and be sure to use #planthatwedding when posting, so you can get our attention! Easy to get in touch with. Email us at hello@thebigweddingplanningpodcast.com or Call and leave a message at 415-723-1625 and you might hear your voice on an episode Learn more about your ad choices. Visit megaphone.fm/adchoices

So many of you have emailed and asked us questions regarding brunch weddings. Timelines, logistics, menu, layout, micro-events...pros, cons, lessons learned. We're sharing it all with you in this episode, including some incredibly detailed insight from a recent ‘brunch bride' listener. Her post-wedding-day notes are a great retrospective about all things brunch. Let's get ourselves a bloody mary and dive in! Big Takeaways Let's talk about the easy part first: Food and Drinks. Early lunch, or full brunch. Everyone loves a boozy brunch! Carving station, omelettes, frittatas, quiche, breakfast foods, fresh fruits and veg and cheese, sweet treats like pastries and donuts, smoked salmon, small bites, chicken and waffles, limited bar - people still drink beer and wine. Spiked hot drinks, bloodies, mimosas - all sorts! Champagne and coffee are a must. An espresso bar? Yes Please. Timeline example: (Be ready for an early morning!) o 6am-8am, makeup and hair (makeup for 4 people, hair for 1) o 8am-9am, get dressed + getting ready photos with photographer o 9am-10am, First Look, Wedding Party, and ½ of family photos o 11am-11:30am, Ceremony o 11:30am-12:30pm, Cocktail Reception (ceremony room flipped) o 12:30pm-4:00pm, Reception Challenges of a brunch wedding: Skewing things early, and making sure everyone's expectations are in line with the earlier day you have planned - your wedding party, VIPs and guests. Keeping things flowing during the reception - do people dance? Will people stay until the end or cut out early? Apparel - brides have told us that they have had trouble picking a wedding dress for their brunch nuptials. Too formal? Too ‘garden party'? Is strapless ok? Tea length or floor length for the bridesmaids? Our advice is to pick the venue and the date before even beginning to start the outfit-hunt. Just like an evening wedding, your clothes will (ideally) ‘fit' the scene. At the end of the day, remember what we always say - do you! If you love it and you're comfortable, it's fine. Hair and Makeup could be VERY early if you have a lot of ladies lined up for services. Might want to think about having your rehearsal dinner on the early side so everybody is ready for an early wedding day! Light! It's going to be light out, you won't get a sunset, or have to race against darkness. We strongly suggest you visit the venue during the time that your wedding will be so you can get a good idea of the light - inside and out. You probably won't need to spend a lot of money on an AV company lighting vendor because the room will be bright enough. Maybe you need to think about draping if the light is too bright in the windows. Don't fight the light - know what you are going to get and harness it! Use what you have to your advantage. Outdoor garden wedding at 10am - perfect! Small wedding parties and live musicians are perfect for brunch. We see those two things in almost every brunch wedding we've planned or been to as a guest or ‘friendor.' Our Brunch Bride's hindsight: · We saved money on food and the venue. Because it was daytime, I felt like we got away with having a simpler menu (i.e., one entrée). Our families enjoy their beverages, so we went more typical alcohol estimates, but we could have saved more by returning what wasn't opened (mostly rose and cava for the mimosas). Finally, our venue base cost was $3k. It was double for a Saturday evening, but it seemed like rates of at least $10k-$15k were the average at other places. Spending less money on the venue meant I didn't have to skimp in other areas. · It's well suited for a Sunday. If an evening wedding was a priority for us, I would have chosen a Friday or Saturday. But Sunday meant that people in NorCal did not have to take off work, which they appreciated. · Creativity! I enjoy evening weddings where there's a fancy dinner, starry skies, and a lot of dancing. But brunch forced us to reimagine many aspects of our wedding, especially décor and music. The vibe I wanted was hip, relaxed, light, and airy. A “garden party” was the closest thing I could think because of the daytime and floral nature. I like what we came up with overall. The flowers and greenery really made it work, even though I know a lot of couples steer away from that. The DJ also did a great job with music; he understood our eclectic but rather chill taste and picked songs appropriate for the setting. And the florist killed it, absolutely loved her work. · A perk of a Sunday wedding: we got our first picks for vendors. We had a 10-month timeframe and although people were already booked on the Saturday, 10/6, they were free on Sunday, 10/7 to help us. Links we referenced none Quotes “I've learned that I cannot actually handle an unlimited mimosa brunch. Boozy brunch...not for me.” - Christy, on being an adult “You think of brunch, you think of being sober. You're not putting on a little black dress. You're more proper. It's not going to last as long as an evening wedding would.” Michelle, on the elements of brunch “Something needs to happen every thirty minutes...that's just a rule of thumb. And that is definitely true for a brunch wedding.” - Christy “Brunch food smells so good. I think it's because the syrup is on heaters a lot of the time. Delicious.” - Christy loves pancakes “You can have anything at brunch. It's an in-between time, anything goes!” - Michelle - freedom! “Good energy. We were way less exhausted than we thought we'd be; with an evening wedding, we would have been dragging by 9pm.” - Our brunch bride Gen, you have to be a morning person! Get In Touch EMAIL: thebigweddingplanningpodcast@gmail.com FACEBOOK: @TBWPpodcast INSTAGRAM: @thebigweddingplanningpodcast BE SURE TO USE THE HASHTAG: #planthatwedding TWITTER: @TBWPpodcast PHONE: (415) 723-1625 Leave us a message and you might hear your voice on the show! PATREON: www.patreon.com/thebigweddingplanningpodcast

Episode 41 has landed where I talk about what I watch around Halloween time, go over your wonderful feedback, and talk more about trying to map out a plan for getting away from Google. Thanks for tuning in and visit pixelswim.com for all my links, articles and other general info. Episode Links Donate to Dave Rich's Kitten on GoFundMe Movies Anywhere App Halloween Viewing: The Simpsons Halloween Specials The Village ParaNorman Nokia 3310 Nokia 8110 iPhone SE LINK: Introducing Twenty Nineteen VIDEO: VFX Artist Reveals the True Scale of the Universe LINK: You know your web page sucks when it cost 7-million dollars to read!

Episode 41 has landed where I talk about what I watch around Halloween time, go over your wonderful feedback, and talk more about trying to map out a plan for getting away from Google. Thanks for tuning in and visit pixelswim.com for all my links, articles and other general info. Episode Links Donate to Dave … Continue reading Episode 041 – Halloween Viewing and More Data Skewing

  After Ian recommends writers Mike Spear and Marcia Fields to Terence's new show; they discuss staffing both their shows with a female focus.  Terence creates his own censor sound when Ian starts comparing the size of their staffs.  Shout out to Kristine Augustyn, who fits both guys' criteria for having a top supervising producer in the field, so they both try to get her.   Executive Producers, showrunners, and production company owners -- Terence Michael and Ian Gelfand have produced over 50 television series and 20 feature films between the two of them.  They're also entrepreneurs, with businesses outside of film and tv, from real estate to start-ups.  Ian lives in New York.  Terence lives in Los Angeles.  This podcast was born from a series of neurotic telephone conversations that began after Terence returned from Louisiana,where he's the executive producer of DuckDynasty, and attempted to prepare Ian to come onboard the next season to direct and showrun. They both realize they're probably the only two people listening.  And that's okay with them.  

Upfronts are here, finally! In this week's Totally Tubular, Tim and I analyze all the relevant scheduling news, make our picks for most promising pilot, and consider why Limitless is being hung out to dry. After that, we dig into the week's premieres, including the very anticipated debut of Preacher and the absolutely unnecessary return of Wayward Pines. Along the way, we break down why Totally Tubular, like CBS's abandoned Drew pilot, skews too female. Segment breakdown: Upfront news round-up (01:18 – 37:39), Netflix's Lady Dynamite (37:40 – 47:21), AMC's Preacher (47:22 – 58:16), Fox's Wayward Pines (58:17 – 01:06:18), and the mailbag (01:06:19– 01:20:07). Our theme song is "On the Television," by BOCrew. (c) 2012 Licensed under a Creative Commons Attribution Noncommercial (3.0) license. Ft: JAVOLENUS / THEDEEPR / JAMES NICK SOLDER

PNC Financial Services' Stuart Hoffman says that the collapse of American energy producers is complicating attempts to gauge the health of the jobs market. He joins Tom Keene and Michael McKee on Bloomberg Surveillance. Learn more about your ad-choices at https://www.iheartpodcastnetwork.com

PNC Financial Services' Stuart Hoffman says that the collapse of American energy producers is complicating attempts to gauge the health of the jobs market. He joins Tom Keene and Michael McKee on Bloomberg Surveillance.

Skewing odd with a jazz bent, US3, Jamiroquai, Smashing Pumpkins, and Happy Mondays.

Thank you to Knitwhisperer for their kind donation. Catching Up: (0:47) Jen saw Saint Vincent, The Book of Life, and Interstellar. She enjoyed them all. The acting is great in Saint Vincent; Book of Life is beautiful, and she definitely thinks Interstellar is definitely worth seeing, but she wasn't wild about the ending. She's been reading Game of Thrones and really liking it. They celebrated a big birthday for Ron with a really nice party and her parents came to visit. She's been spinning up her Knitpicks Wool of the Andes roving. She's trying to make a 2-ply fingering. And she went to WeFF. She had a lot of fun and won a ton a stuff in the door prize drawings and bought some really nice roving from Morro Fleece Works and RedFish DyeWorks and buttons. Laura was a vendor at WEFF and had a good day. She split her booth with Kamalei's Naturals. She bought some yarn from RedFish. She went to Disneyland with her brother and his kids. She's been watching Buffy Season 3 to prepare for the Sunnydale Yarn Club. She also finished the first half of Season 7 of Doctor Who. She's been dying a lot and trying to keep her mind off of some health concerns that are most likely nothing, but that are causing some stress. We mention Forbidden Woolery. In the Knitting Bag: (20:05) Jen has been still working on her Heirloom Layette Set by Kerin Dimeler-Laurence out of Cascade Heritage in Snow. She has not yet heard back from Knitpicks, so she will create her own edging. And she is working on the sweater instead. She's working on her plain socks out of FabFunkyFibres 15 Coloured Rainbow self-striping yarn. She started The Age of Brass and Steam by Orange Flower Yarn out of Feederbrook Farms Entropy in the colorways Nebula and Paradox--she is going to do a gradual transition between the two. She also started a plain Customfit pullover using Cascade Heritage in Deep Plum. She is doing a close-fit, 3/4 length sleeve in tunic length, with a scoop neck and seed stitch border. And finally she started the Porcupine Blanket from 60 Quick Baby Knits out of Cascade 220 Superwash. She thinks the porcupines look more like hedgehogs. Laura is working on the Motoring Madness mittens by Audrey Nicklin for her husband out of custom-dyed Dizzy Blonde DK. She is also working on Knitted Scale Mail Gloves in an Iron Man theme by CraftyMutt for her granddaughter's father. She is doing them out of Brown Sheep Worsted in the Red Fox colorway. She decided to crochet the repulsors and applique them on, instead of doing intarsia. And she continues to work on her Yggdrasil Afghan by Lisa Jacobs out of reclaimed Berroco Vintage Chunky in Mocha. She's on the applied edging and it's a lot of knitting. We mention Sock Architecture by Lara Neel. Finished Objects: (28:15) Jen finished her Chickadee Cardigan by Ysolda Teague from Little Red in the City out of Quince and Co. Chickadee in Rosa Rugosa, Slate, Egret, and Lichen. She just needs to put buttons on it, but she loves it so much she's been wearing it without buttons. The sleeves are little short for her taste, but just because she likes really long sleeves. Laura finished a hat for Halos of Hope out of Knitpicks Brava Worsted in orange, lavender, and some neutral greys and browns. PM or email Laura if you're local and have hats for Halos; she is willing to send them. Devil's Tower (31:43) Jen has been working on finishing (weaving in ends etc) on her Playful Stripes Cardigan and on her Mustachioed blanket. Laura may put her Yggdrasil in Devil's Tower to work on some gift knitting. (So she is decidedly not participating in the Knitmore Girls Grinchmas Contest). We mention Watty's Wall Stuff Frog Pond: (36:40) Luckily, we have both avoided the Frog Pond. On Deck: (36:51) Jen will make a layette based on the Baby Yours Sweater. She will make a second Playful Stripes Cardigan, the Hitofude Cardigan, and a Rockefeller for Ron. Laura will make the Night Blooming Shawlette for the Sunnydale Yarn Club KAL. She also has on the list Quinty by Bernadette Ambergen, the Death Star by Patricia Castillo,  Ink by Hanna Maciejewska, the Crochet Fan Shawl by Valerie Martin, and Art Déco and Dreambird by Nadita Swings, and the the Effortless Cardigan by Hannah Fettig. Knit Culture: (42:55) We talk a little bit of Stashdown. We loved October's entries. Congratulations to ShadowAP, you win a copy of Sock Architecture, courtesy of Cooperative Press. November's theme is food, so put your FOs in the thread. December's theme is "A Gift for Myself". Knit something that you really love. Treat yourself. Use that skein that is so pretty or work on that project that you love. We review Knitting 20th Century Art by Deborah Tomasello. We totally love this book. The patterns are really clever and inspired and there are nice overviews of modern art movements. We both appreciate the whimsy and the beauty of her patterns and we like the styling. Geek Culture: (54:39) We talk about the discovery of part of Amelia Earhart's plane. We also talk about the Rolling Stone Reader's poll about the Ten Best Stephen King books. We weigh in our favorites and would love to hear about your favorite horror books. And there is a Firefly Clue Board game. For serious. Events: (1:03:16) Stitches West is February 19-22 and both Jen and Laura will be there. Laura is vending and Jen will be taking a ton of classes, but come say hi! Vogue Knitting LIVE! is at the Pasadena Convention Center on April 17-19. Laura may take some classes and Jen may go to the marketplace.

CS3 Announcement; Skewing and Shearing; Annoying Section Prefixes, Obscurity of the Week: Simulate Paper Color ----- Details below, or visit http://indesignsecrets.com/category/podcasts for show notes, links, and to leave a comment! ----- Listen in your browser: InDesignSecrets-044.mp3 (9.6 MB, 20:01 minutes) (a transcript of this podcast will be posted shortly) Adobe CS3 Announcement David at the Creative Suite Show; Anne-Marie in Duluth Skewing text and objects; skew vs. shear Working around the Section Prefix annoyance Obscure InDesign Feature of the Week: Simulate Paper Color Links mentioned in the podcast: InDesign Conference in New York, New York (June 4–6, 2007) Listener Comment Line: +1-206-888-INDY (-4639) Talk to us, baby: Leave a message!

Die X-chromosomal gebundene Adrenoleukodystrophie stellt eine vererbte Störung der peroxisomalen ß-Oxidation von Fettsäuren dar, die zu einer Akkumulation von überlangkettigen Fettsäuren in allen Körperflüssigkeiten führt. X-ALD wird durch Mutationen im ALD-Gen verursacht, welches ein peroxisomales Membranprotein aus der Superfamilie der ABCTransporter (ATP-binding cassette) kodiert. Die Erkrankung führt zu einer fortschreitenden Demyelinisierung des ZNS, einer peripheren Neuropathie sowie adrenokortikaler Insuffizienz. Es findet sich jedoch eine sehr hohe Variabilität phänotypischer Verlaufsformen. Aus bislang unklaren Gründen zeigt ein Großteil der heterozygoten Überträgerinnen - im Gegensatz zu der überwiegenden Mehrzahl anderer X-chromosomal vererbter Erkrankungen - sowohl die biochemischen als auch die klinischen Merkmale einer X-ALD in abgemilderter Form. Zur Erklärung dieses Phänomens sollte die Untersuchung der X-Inaktivierung heterozygoter Überträgerinnen beitragen, da in der Vergangenheit postuliert wurde, daß eine zugunsten des mutierten ALD-Allels verschobene X-Inaktivierung (mit-)verantwortlich sei für das Auftreten erhöhter Konzentrationen überlangkettiger Fettsäuren und neurologischer Symptome bei ALDÜberträgerinnen. Zur Untersuchung der X-Inaktivierung wurde der hochinformative Androgenrezeptor-Test etabliert und in einigen Punkten modifiziert und verbessert. Das Testprinzip beruht auf der PCRAmplifikation eines hochpolymorphen CAG-Repeats im Exon 1 des Androgenrezeptor-Gens nach einer Inkubation von genomischer DNA mit methylierungssensitiven Restriktionsenzymen. Die Verwendung eines fluoreszenz-markierten Primers in der PCR ermöglichte eine präzise automatisierte Auswertung mittels Fragmentanalyse. Neben einer Bestimmung der überlangkettigen Fettsäuren im Plasma wurde der Heterozygotenstatus der ALD-Überträgerinnen durch eine Mutationsanalyse des ALD-Gens eindeutig belegt. Dabei konnten in allen 15 untersuchten Familien Mutationen im ALD-Gen identifiziert werden. Bei 8 Familien fanden sich neue, bislang unveröffentlichte Mutationen. Das Mutationsspektrum umfaßte 10 Missense- (67 %), zwei Nonsense- (13 %), zwei Splice-Site- Mutationen (13 %) und eine Frameshift-Mutation (6 %). Die X-Inaktivierungsmuster in Leukozyten heterozygoter ALD-Überträgerinnen wurden erstmals im Vergleich zu einem verwandten und einem nicht-verwandten Kontrollkollektiv untersucht. Bei 7 von 22 Überträgerinnen (32 %) zeigte sich eine ausgeprägte Verschiebung der X-Inaktivierung (Skewing) zugunsten eines Allels (> 80:100). Im Gegensatz dazu war ein ausgeprägtes Skewing weder bei den Nicht-Überträgerinnen aus ALD-Familien noch bei den Kontrollen zu beobachten. In diesen Gruppen fanden sich nur random X-Inaktivierung und mildes Skewing zu annähernd gleichen Teilen. Bei beiden Gruppen glich die Verteilung der XInaktivierungsmuster einer Gauss’schen Normalverteilungskurve. Die Unterschiede zwischen ALD-Überträgerinnen und unverwandtem Kontrollkollektiv erwiesen sich als statistisch hochsignifikant. Eine Korrelation zwischen dem Grad der X-Inaktivierung in Leukozyten heterozygoter ALDÜberträgerinnen und deren biochemischen Parametern (Konzentration überlangkettiger Fettsäuren im Plasma) war nicht nachweisbar. Unsere Daten belegen, daß das häufige Auftreten einer Verschiebung der X-Inaktivierung zugunsten eines Allels bei ALD-Überträgerinnen mit dem mutierten ALD-Allel in Zusammenhang steht und wahrscheinlich durch Selektionsmechanismen verursacht wird. Diese Selektionsmechanismen wirken nach dem primären X-Inaktivierungsprozeß. Andere sekundäre Einflußvariablen wie Alter oder genetische Faktoren des X-Inaktivierungsprozesses selbst wurden mit hoher Wahrscheinlichkeit ausgeschlossen. Anhand von Transkriptanalysen in kultivierten Fibroblasten konnte darüberhinaus gezeigt werden, daß einerseits eine Selektion zugunsten des Wildtyp-Allels, andererseits jedoch auch eine Selektion zugunsten des mutierten Allels vorkommt. Der bislang in der Literatur postulierte Selektionsvorteil des mutierten ALD-Allels wird somit in Frage gestellt.