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6 episodes with Fischbach
5 episodes with Fischbach
4 episodes with Fischbach
5 episodes with Fischbach
4 episodes with Fischbach
2 episodes with Fischbach
2 episodes with Fischbach
2 episodes with Fischbach
2 episodes with Fischbach
In dieser Folge spriche ich mit der ganzheitlichen Frauenärztin Dr. Michaela Fischbach über ein Thema, das viele Frauen betrifft – aber oft tabuisiert wird: die Wechseljahre. Gemeinsam klären wir auf, räumen mit Mythen auf und geben praktische Tipps für Körper, Seele und Alltag.Themen dieser Episode:Was genau sind die Wechseljahre und welche Phasen gibt es?Hormonelle und körperliche Veränderungen: von Zyklusschwankungen bis „Gehirnnebel“Warum viele Frauen schon ab Mitte 30 erste Symptome spürenGanzheitliche Begleitung: Ernährung, Nährstoffe, Stressmanagement & BewegungHormonersatztherapie – sinnvoll oder gefährlich? Dr. Fischbach klärt aufWie wir Familie und Partner in diese Lebensphase einbeziehen könnenTipps für mehr Wohlbefinden, Selbstfürsorge und offene KommunikationAngebote und Programme von Dr. Fischbach für betroffene Frauen———————————————————Im Podcast erwähnt:Zyklus-Balance - Wie du mit Female Food dein Potenzial ausschöpfstDr. Michaela FischbachWebsite: www.frauengesundheit-fischbach.de/Instagram @frauenwissen.dr.ela Menopause clarity: dein Weg raus aus dem Wechseljahr Chaos——————————————————Du möchtest keine Folge verpassen und zusätzliche Tipps direkt in Dein E-Mail Postfach bekommen? Dann melde Dich für meinen Newsletter an und erhalte meine 11 darmfreundlichen Rezepte, die auch Meal Prep geeignet sind.Newsletter & FreebieDeine Gedanken zu meinem Podcastfolge kannst Du mir gerne auf Instagram unter dem Post mitteilen oder auch per Mail zusenden: info@hannah-willemsen.com.Du würdest mir einen riesen Gefallen tun, wenn Du meinen Podcast auf iTunes mit 5 Sternen bewertest. So finden andere diesen Podcast auch und erhalten ebenfalls wertvolle Tipps zum Thema gesunde Ernährung.Alles LiebeDeine Hannah
Nahe Dran vom 14.04.2025 - Kupferbergwerk Fischbach by Antenne Bad Kreuznach / Idar-Oberstein
Anna nous parle de poisson à bras, de vol de chewing gum, de l'odeur de la clope, de relations toxiques, de courage, de validation par autrui, et de romantisme guidée par "Un autre que moi" de Fischbach. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.
In den Köpfen da draußen schwirren immer viele tolle Ideen herum und viele dieser Köpfe möchten mit diesen Ideen ein StartUp gründen. Da stellen sich natürlich immer viele Fragen. Wo bekomme ich Unterstützung? Muss ich nebenbei weiter arbeiten gehen, um meinen Lebensunterhalt zu finanzieren? Wie kann ich die Idee in die Umsetzung bringen? Und und und. Passend zu diesen Fragen, wollen wir heute mal über ein Instrument sprechen, das genau dort ansetzt und diese Unsicherheiten nehmen soll. Nämlich das Gründungsstipendium Schleswig-Holstein. Dafür habe ich mir meinen Kollegen Broder Fischbach eingeladen und spreche mit ihm in dieser Episode mal über verschiedene Aspekte, den Prozess und den Ablauf des Stipendiums. 02:27 Wer bist du und was machst du? 03:49 Was macht das Gründungsstipendium SH so besonders? 04:47 Wie viel Geld gibt es denn eigentlich? 06:50 Was hat sich über die Jahre getan? 10:20 Für wen ist das Stipendium gedacht? Wer darf sich bewerben? 12:04 Bewerbungsprozess 20:00 Was erwartet uns im Stipendium? 24:33 Wohin kann das Stipendium führen und wie kann es danach weiter gehen? 27:13 Beispiele 28:57 Tipps von Broder Weitere Infos: www.gruendungsstipendium-sh.de www.wtsh.de Music: freemusicarchive.org/music/Checkie_…_Dilemma_ID_03 License: creativecommons.org/licenses/by-nc-nd/4.0/deed.de
Eine Spitzen-Folge mit dem Chef des deutschen Marktführers Schüco - absolute Empfehlung! Wer sich in seinem Leben schonmal ein Fenster genauer angeschaut hat, der kennt wahrscheinlich Schüco. Der deutsche Fenster- & Türenriese ist auch ein internationaler Player - und steht für viel mehr als nur die “Augen des Gebäudes”. Die Themen des DIGITALWERK Podcasts mit Andreas Engelhardt im Überblick: (00:00) – Worum gehts in der Folge? (02:08) – Was macht ein persönlich haftender Gesellschafter? (05:35) – Andreas Engelhardts Werdegang: Vom faulen Schüler zum CEO (10:07) – Politisches Engagement und erste Führungserfahrungen (13:15) – Die Bedeutung von Freiheit und Gerechtigkeit (19:12) – Einstieg bei Schüco: Wie kam es dazu? (22:08) – Führung in einem Familienunternehmen (27:51) – Schüco damals und heute: Vom Fensterhersteller zur nachhaltigen Bauchemie (30:56) – Kreislaufwirtschaft und Nachhaltigkeit als Geschäftsmodell (32:21) – Marktführerschaft: Was macht Schüco erfolgreich? (35:50) – Internationale Märkte: Deutschland, USA, Indien & Middle East (42:38) – Persönliche Kundenbeziehungen & Geschäftsmentalität weltweit (46:34) – Krisenzeiten: Pandemie, Krieg & Management-Herausforderungen (48:04) – Politische Rahmenbedingungen und Herausforderungen in Deutschland (52:36) – Zukunftsausblick: Was muss sich in Politik und Wirtschaft ändern? Werbepartner unserer heutigen Folge ist Leo-Software Was passiert, wenn eine Software für Sanierungsprojekte nicht von irgendwelchen Nerds entwickelt wird – sondern mit den Praktikern auf den Baustellen? Dann wird plötzlich alles ganz einfach. Und die Planung und Steuerung der Kapazitäten endlich effektiv und übersichtlich. Fischbach, die LEG und die GWG Wuppertal haben sie schon: LEO. Die Praxissoftware für Sanierungsprojekte in der Wohnungswirtschaft. Einfach informieren auf https://leo-software.de/
In dieser Folge spricht Michél mit dem Hamburger Immobilienentwickler Prof. Dr. Michael Becken, der bei der bekannten Hamburger Becken-Gruppe tätig ist. Michael ist auch Hochschulprofessor und Rektor, und versucht auch, als Politiker durchzustarten. Außerdem haben wir über Michaels Migrationsgeschichte geredet, über den Elbtower und den Immobilienmarkt! Die Themen des DIGITALWERK Podcasts mit Michael Becken im Überblick: (00:00) - Worum geht es in der Podcastfolge? (03:53) - Michaels Werdegang: Von der Migration nach Deutschland bis zur Immobilienbranche (12:28) - Einstieg ins Familienunternehmen Becken und erste Herausforderungen (16:09) - Wandel der Becken-Gruppe: Vom Projektentwickler zum Investmenthaus (21:37) - Immobilienmarkt aktuell: Herausforderungen, Zinsen und Zukunftsperspektiven (29:50) - Der Elbtower: Warum Becken nicht von Anfang an dabei war (37:33) - Finanzierung großer Bauprojekte und die Rolle von Investoren (41:57) - Northern Business School: Michaels Rolle als Professor und Rektor (46:59) - Einstieg in die Politik: Warum Michael Becken für die CDU aktiv ist (52:04) - Bezahlbarer Wohnraum: Lösungsansätze und politische Forderungen (56:45) - Schnellfragerunde: Persönliche Einblicke und Abschluss Werbepartner unserer heutigen Folge ist Leo-Software: Was passiert, wenn eine Software für Sanierungsprojekte nicht von irgendwelchen Nerds entwickelt wird – sondern mit den Praktikern auf den Baustellen? Dann wird plötzlich alles ganz einfach. Und die Planung und Steuerung der Kapazitäten endlich effektiv und übersichtlich. Fischbach, die LEG und die GWG Wuppertal haben sie schon: LEO. Die Praxissoftware für Sanierungsprojekte in der Wohnungswirtschaft. Einfach informieren auf https://leo-software.de/ Für mehr Infos rund um DIGITALWERK auf den spannendsten Baustellen abonniere jetzt den YouTube Kanal: https://www.youtube.com/@digitalwerk-podcast Oder schaut auf unseren anderen Kanälen vorbei! WEBSEITE: https://www.digitalwerk.io/ INSTAGRAM: https://www.instagram.com/digitalwerk.io/ LINKEDIN: https://www.linkedin.com/company/digitalwerk-io/ Wir freuen uns, wenn du unsere Inhalte teilst, um andere zu inspirieren!
VBI-Präsident Jörg Thiele liefert im Podcast eine Bestandsaufnahme für das deutsche Ingenieurwesen 2025 Jörg ist nicht nur Präsident des Verbands Beratender Ingenieure (VBI), sondern auch selber Unternehmer. Aus dieser spannenden Doppelrolle hat er einen besonders gründlichen Blick auf die aktuellen Probleme. Die Themen des DIGITALWERK Podcasts mit Jörg Thiele im Überblick: (00:00) - Einleitung: Worum geht es in dieser Folge? (02:40) - Jörgs Weg ins Ingenieurwesen (06:23) - Unternehmensübernahme nach der Wende (08:43) - Krise 2003/2004 und der Weg zur Stabilität (12:27) - Jörgs Weg zum VBI (17:52) - Recruiting und Fachkräftemangel (22:52) - Digitalisierung: Fortschritte und Hindernisse (30:17) - Politik und Bauwesen: Herausforderungen für die Zukunft (35:40) - Der Zustand der Infrastruktur in Deutschland (44:33) - Fünf schnelle Fragen an Jörg Thiele Werbepartner unserer heutigen Folge ist Leo-Software: Was passiert, wenn eine Software für Sanierungsprojekte nicht von irgendwelchen Nerds entwickelt wird – sondern mit den Praktikern auf den Baustellen? Dann wird plötzlich alles ganz einfach. Und die Planung und Steuerung der Kapazitäten endlich effektiv und übersichtlich. Fischbach, die LEG und die GWG Wuppertal haben sie schon: LEO. Die Praxissoftware für Sanierungsprojekte in der Wohnungswirtschaft. Einfach informieren auf https://leo-software.de/
Multiunternehmer Tobias Waltl, Gründer & Vorstand spricht im Podcast mit Michél über seine krasse Karriere, die ihn wirklich herumgeführt hat! Von der eigenen Bank bis hin zur eigenen Hotelkette und einem patentierten Ziegel-Modul: In diesem Gespräch gehts um eine kometenhafte Erfolgsgeschichte - mit Herz! Die Themen des DW Podcast mit Tobias Waltl im Überblick: (00:00) – Darum geht's in der Folge! (00:56) – Tobias Waltls Weg vom Banklehrling zum Unternehmer (02:01) – Warum er eine eigene Bank gründete (07:31) – Der Wechsel in die Immobilienbranche (14:11) – Von der Bank zum Schreiner: Ein neuer Karriereweg (19:26) – Der Einstieg in die Hotelbranche (26:02) – Modulbau als Lösung für schnelles Wachstum (30:34) – Wie Tobias Waltl sein Unternehmen finanziert hat (34:33) – 1000 Mitarbeiter & 200 Millionen Umsatz: So funktioniert das Geschäft (40:21) – Unternehmertum & Verantwortung: Warum er immer weitermacht Werbepartner unserer heutigen Folge ist Leo-Software: Was passiert, wenn eine Software für Sanierungsprojekte nicht von irgendwelchen Nerds entwickelt wird – sondern mit den Praktikern auf den Baustellen? Dann wird plötzlich alles ganz einfach. Und die Planung und Steuerung der Kapazitäten endlich effektiv und übersichtlich. Fischbach, die LEG und die GWG Wuppertal haben sie schon: LEO. Die Praxissoftware für Sanierungsprojekte in der Wohnungswirtschaft. Einfach informieren auf https://leo-software.de/
In 4. Generation führt Philipp Utz mit seinem Bruder das 114 Jahre alte Familienunternehmen. Aus einem Produzenten von Schuhcreme, Bohnerwachs und Seife wurde ein international erfolgreicher Anbieter von Bodensystemen und allem drum herum. #Familienunternehmer #Mittelstand #Expansion #Fußboden (00:00) - Um was geht es in der Podcastfolge? (02:08) Die Geschichte von Uzin Utz: Vom Schuhcremehandel zur Bauchemie (06:13) Die Bedeutung von Familienwerten und Unternehmensführung (17:51) Markteintritt in die USA: Strategien und Learnings (19:41) Markenportfolio und Internationalisierung (24:59) Zusammenarbeit zwischen Geschwistern im Familienunternehmen (33:06) Der Einfluss politischer Rahmenbedingungen auf globale Märkte (35:59 Perspektiven für die Bauwirtschaft 2025 (38:06) Fünf schnelle Fragen zum Abschluss Werbepartner unserer heutigen Folge ist Leo-Software: Was passiert, wenn eine Software für Sanierungsprojekte nicht von irgendwelchen Nerds entwickelt wird – sondern mit den Praktikern auf den Baustellen? Dann wird plötzlich alles ganz einfach. Und die Planung und Steuerung der Kapazitäten endlich effektiv und übersichtlich. Fischbach, die LEG und die GWG Wuppertal haben sie schon: LEO. Die Praxissoftware für Sanierungsprojekte in der Wohnungswirtschaft. Einfach informieren auf https://leo-software.de/ Für mehr Infos rund um DIGITALWERK auf den spannendsten Baustellen abonniere jetzt den Pocast auch auf YouTube: https://www.youtube.com/@digitalwerk-podcast Oder schaut mal auf unseren anderen Kanälen vorbei! WEBSEITE: https://www.digitalwerk.io/ INSTAGRAM: https://www.instagram.com/digitalwerk.io/ LINKEDIN: https://www.linkedin.com/company/digitalwerk-io/
Der Multiunternehmer und Easy-Apotheken-Gründer Oliver Blume spricht im Podcast über seine unzähligen Unternehmungen. Das disruptive Unternehmertum und auch die “Rulebreaker”-Affinität schiebt Oliver auf ein Gen. Im Podcast mit Michél blickt er auf eine beeindruckende Karriere zurück - die immer noch spannendes bereithält. Nächstes Thema: Fernsehtürme! #Immobilien #Hotels #Quantencomputer #Fernsehtürme Die Themen des DW Podcast mit Oliver Blume im Überblick: 00:00:00 - Um was geht es in der Podcastfolge? 00:02:17 - Warum & Wieso man einen Fernsehturm kauft! 00:07:02 - Boxhotel: Idee und Umsetzung 00:09:28 - Werbepause: Leo-Software 00:18:08 - Einstieg ins Quantencomputing 00:22:19 - Kriterien für Investitionen und Geschäftsmodelle 00:26:13 - Status und Herausforderungen im Quantencomputing 00:37:36 - Erfolgsrezept und abschließende Fragen Werbepartner unserer heutigen Folge ist Leo-Software: Was passiert, wenn eine Software für Sanierungsprojekte nicht von irgendwelchen Nerds entwickelt wird – sondern mit den Praktikern auf den Baustellen? Dann wird plötzlich alles ganz einfach. Und die Planung und Steuerung der Kapazitäten endlich effektiv und übersichtlich. Fischbach, die LEG und die GWG Wuppertal haben sie schon: LEO. Die Praxissoftware für Sanierungsprojekte in der Wohnungswirtschaft. Einfach informieren auf https://leo-software.de/
This week, we're joined by Erica Fischbach, Director of Colorado Ballet Academy, to talk about the school's full-time training programs, including the trainee and studio company levels. While the studio company is part of the main company, Erica shares everything you need to know about it. We also discuss how CBA recruits dancers, what interested students can do to be considered for admission, as well as the performance opportunities available at each level. Plus, Erica explains why Colorado Ballet Academy chooses to compete and how it benefits their dancers. Whether you're aiming for a spot in the studio company or looking to join the Academy, this episode has the details you need! You can learn more about Colorado Ballet Academy at these links: Colorado Ballet Summer Intensive Programs Young Dancer Workshop - be sure to read about CBA's new family friendly housing opportunity for young dancers! More Links: Support Ballet Help Desk Buy Corrections Journals Instagram: @BalletHelpDesk Facebook: BalletHelpDesk Ballet Help Desk Music from #Uppbeat: https://uppbeat.io/t/ian-aisling/new-future License code: MGAW5PAHYEYDQZCI
durée : 00:27:49 - Bienvenue chez vous en Alsace, les spécialistes - Christine Fischbach, conteuse professionnelle, fait vivre les contes et légendes d'Alsace avec passion. En cette période de fêtes, elle nous transporte dans la magie de Noël et partage son univers riche en traditions et en imagination.
durée : 00:03:01 - Christine Fischbach, contes de Noël - Christine Fischbach, conteuse professionnelle, nous parle de l'événement du weekend au centre culturel Marie Hart à Bouxwiller.
Have you ever set a goal and wondered why is this really important to me? Or did you set an objective and lose your motivation while trying to achieve it? I welcome back to the show Professor Ayelet Fishbach, Eric J. Gleacher Distinguished Service Professor of Behavioral Science and Marketing at the University of Chicago. Ayelet is a motivation scientist and author of Get it Done: Surprising Lessons from the Science of Motivation. Ayelet is also known as the godmother of motivation! Ayelet sheds light on the low correlation between wealth, happiness, and success and emphasizes the importance of knowledge over sheer willpower. We discuss the role of situational awareness and the art of reframing to navigate obstacles and stay on track with your goals. Throughout the conversation, Ayelet shares actionable strategies for reframing discomfort as growth, anticipating obstacles, and continuously refining our understanding of what drives us. Whether you're facing financial decisions or personal growth challenges, we identify strategies to help you align your goals with your life's purpose. Please enjoy my conversation with Professor Ayelet Fishbach. Connect with Paul Contact Paul here or schedule a time to meet with Paul here. For resources discussed in this episode, visit tammacapital.com/podcast. Follow Paul on LinkedIn, Instagram, and Facebook. And feel free to email Paul at pfenner@tammacapital.com with any feedback, questions, or ideas for future guests and topics.
Joining Lisa and Sasha in the Today Radio studios are the planners of Differdange's Fashion Week Luxembourg, sneaker savvy Today Radio presenter Steven Miller, and Laura da Silva – a fashion-forward nurse, tattoo artist and advocate for breast cancer support and awareness. Starting with a review of the week's global news with Sasha Kehoe, we discuss: US Election Just one month away and Melania Trump has declared her support for a woman's right to control her own body, including abortion. https://www.theguardian.com/us-news/2024/oct/02/melania-trump-memoir-defends-abortion-rights JD Vance, Donald Trump's pick for vice-president, has indicated he would support a national abortion ban https://edition.cnn.com/2024/07/17/politics/kfile-jd-vance-abortion-comments/index.html Pelicot Trial Rape Case in France The horrific mass rape trial of 71 year old Gisèle Pelicot continues, creating debate about the culture of male domination in France and across borders https://www.france24.com/en/live-news/20240927-french-rape-trial-sparks-timid-debate-about-masculinity Teleworking no longer Amazon now requires all employees to return to the office, sparking debate amongst many companies to rethink their working from home / office balance for maximum productivity / employee satisfaction, especially when long commutes are a feature of working in Luxembourg for many. Grand Duke Abdication Hereditary Grand Duke Guillaume will officially assume the role of Lieutenant Representative on 8 October, as appointed by his father the Grand Duke. In September Grand Duke Henri and Grand Duchess Maria Teresa moved to their Fischbach residency allowing their son, Hereditary Grand Duke Guillaume and his family to take over Berg Castle in Colmar-Berg. https://today.rtl.lu/news/luxembourg/a/2207770.html Real Art vs Posters Scientists in the Netherlands using eye-tracking and MRI scans found an enormous difference between genuine works and posters. A neurological study revealed that real works of art in a museum stimulate the brain in a way that is 10 times stronger than looking at a poster. Commissioned by the Mauritshuis Museum in The Hague, home to Johannes Vermeer's Girl with a Pearl Earring, the independent study used eye-tracking technology and MRI scans to record the brain activity of volunteers looking at genuine artworks and reproductions. https://www.theguardian.com/science/2024/oct/03/real-art-in-museums-stimulates-brain-much-more-than-reprints-study-finds Fashion Week Luxembourg Livia Smith, Communication Strategist for Luxembourg Fashion Week talks about its growth from the starting point six years ago, with Fabiola Puga still at the helm. This year there will be twelve national and international designers. Luxembourg Fashion Week hopes to become part of the cultural fabric of the hospitality and economy of Luxembourg. Livia also talks about her own use of fashion to help create confidence for someone who is naturally shy. Max Felten, Chief Economist and City Manager of Differdange returns to talks about why Differdange will, once again, host Luxembourg Fashion Week. Natalia Wrona, in charge of the promotion for Differdange City Management, explains the three different locations this year, including one at the International School in Differdange, celebrating all children, with two autistic children taking to the catwalk. AquaSud Differdange is another of the three locations for the Fashion Week, and Céline Moreira, their Communication Manager, explains the difficulty in using an aquatic setting for a fashion show! Céline also talks about the link to Pink October and how emphasising the beauty in diversity. A theme throughout today's discussion is the power of self-acceptance, and promotion of a positive body image regardless of challenges. Laura da Silva overcame breast cancer ten years ago. Now, she spends her time between nursing at CHL and running her own business as an image consultant and tattoo artist, helping other women who have gone through breast cancer. She travels around with a pink chair, which is a reminder to those who have dealt with cancer that there is a lot of waiting and sitting, for both the patient, but also for their friends and family. https://www.instagram.com/luxembourgfashionweek My colleague, Steven Miller, a presenter at Today Radio is renowned in the office for his sneaker collector. Steven started his collection at the age of 15, peaking at 550 in 2017. He talks about sneaker collecting as an alternative investment, where ‘sneakerheads' of this world are happy to spend thousands on one pair. Steven also loves Japanese streetwear designers, specialising in minimalist but thoughtful creations. Collector of sneakers since age 15 (peaking at 550 pairs in 2017) Completed a course in ‘Sneaker Essentials' with the Fashion Institute of Technology in New York in 2020; covering everything from history and design to manufacturing and retail Favoured fashion subject is Japanese designers and streetwear Advocate for pre-loved/owned clothing and the Japanese art of ‘Sa-shiko' (mending/repair) Please do subscribe via Apple and / or Spotify. It would be great if you could rate and review too — as it helps others find the podcast. Tune in to The Lisa Burke Show on Today Radio Saturdays at 11am, Sundays at noon, and Tuesdays at 11am.
Rep. Michelle Fischbach (R-MN) joins "Forbes Newsroom" to preview the first vice presidential debate between Sen. JD Vance (R-OH) and Gov. Tim Walz (D-MN). See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Agile Verwaltung – kann es so etwas geben? Es kann es nicht nur geben, es gibt es schon, und agile Verwaltung gewinnt zunehmend an Bedeutung und Akzeptanz. Dies zeigt ein Buch mit dem Titel Agile Verwaltung 2040 – Visionen, Methoden, Erfahrungen, das soeben im Carl-Auer Verlag in der von Torsten Groth herausgegebenen Reihe Management / Organisationsberatung erschienen ist. Die Herausgeber:innen Peter Bauer, Christiane Büchter, Jan Fischbach, Alexander Joedecke und Wolf Steinbrecher, allesamt erfahrene Akteur:innen und Berater:innen in verschiedenen Feldern im Kontext Verwaltung, trafen sich zum Gespräch bei Carl-Auer Sounds of Science. Wir sprechen zunächst über den Entstehungsprozess eines so herausfordernden wie herausragenden Buches. Im Zentrum des Gesprächs stehen basale Werte einer zukunftsfähigen Verwaltung – wie beispielsweise Partizipation von Mitarbeitenden und Bürger:innen, Umgang mit Widersprüchlichkeit und Paradoxien – sowie die Frage von Notwendigkeit, Sinn und Praktikabilität von Digitalisierung. Wir sprechen auch über Erfahrungen mit Agilität von und in Verwaltung und über die Aussichten agiler Verwaltung in der näheren Zukunft. Viel Spaß im Gespräch bei Carl-Auer Sounds of Science. Folgen Sie auch den anderen Podcasts von Carl-Auer: autobahnuniversität www.carl-auer.de/magazin/autobahnuniversitat Blackout, Bauchweh und kein` Bock www.carl-auer.de/magazin/blackout…eh-und-kein-bock Cybernetics of Cybernetics www.carl-auer.de/magazin/cybernet…s-of-cybernetics Frauen führen besser www.carl-auer.de/magazin/frauen-fuhren-besser Formen (reloaded) Podcast www.carl-auer.de/magazin/formen-reloaded-podcast Heidelberger Systemische Interviews www.carl-auer.de/magazin/heidelbe…ische-interviews Zum Wachstum inspirieren https://www.carl-auer.de/magazin/zum-wachstum-inspirieren Zusammen entscheiden https://www.carl-auer.de/magazin/treffpunkt-entscheiden
We will not yield. We will not bend. We will STAND OUR GROUND. All eyes are on South Dakota as citizens lock arms to fight for their God-given, Constitutionally-protected private property rights. In an explosive interview, Ed Fischbach (known as the Godfather of the carbon pipeline battle), exposes the greed, corruption, and power grab happening in our beautiful home state. Together, we celebrate the victories when people get involved and stand firm in what is right.Pre-Order Stand Your Ground shirts: https://amandaradke.com/search?q=pre-order+stand+your+groundPresented by Point Pleasant Angus | Bid on Beef | CK6 Consulting | CK6 Source | Real Tuff Livestock Equipment | Redmond RealSalt | By-O-Reg+ | Dirt Road RadioEnjoy special discounts from my podcast partners:Earn $25 to shop in your first auction at www.BidOnBeef.com when you register your account.Save on Redmond Real Salt with code RADKE at https://shop.redmondagriculture.com/And mention my name when you buy Real Tuff equipment for a special add-on bonus on your delivery. www.realtuff.com
The following political analysis is from Business-Industry Political Action Committee (BIPAC) Senior Political Analyst Jim Ellis. BIPAC is an independent, bipartisan organization. It is provided solely as a membership benefit to the organization's 200-plus member companies and trade associations. The views and opinions expressed do not necessarily represent those of any particular member or organization.
On "Forbes Newsroom," Rep. Michelle Fischbach (R-MN) gave her take on the selection of Gov. Tim Walz (D-MN) to be Vice President Kamala Harris's running mate, the allegations of stolen valor, and his record in office.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
We are just under three weeks away from the primary. Leading up to August 13th, we're taking a look at some races that our politics team will be keeping and eye on. We start with congressional district seven. Two-term U.S. Representative Michelle Fischbach carved out a solidly conservative reputation at the state capitol before winning a western Minnesota congressional seat four years ago. Yet some in her party don't think Fischbach is conservative enough, and they're backing challenger Steve Boyd in the primary. The winner will be heavily favored to secure the seat in November. MPR senior politics reporter Clay Masters joined MPR News host Cathy Wurzer to break down the race.
“We don't have to feel shame about some of those ways that we react.” –Heidi FischbachStuck at 11 all the time? Overreactive? Think rest is a dirty word? This conversation about our nervous system with nervous system coach Heidi Fischbach is for you. She helps people feel at home in their bodies and go from anxiety and overwhelm and shut down to authentic connection.This is one of my favorite topics — one I've been working on myself for a while now — and I'm excited to help you get started or make a plan to move forward with nervous system work. Our nervous system connects our bodies, minds, and emotions — and impacts our relationships.One of the things I love about nervous system resetting is that it doesn't have to take years to undo something. As Heidi says, our bodies are good at being in the now. We can make a body-based shift that changes a lot.We talk about: Different states of our nervous system — and what happens when we get stuck in oneBurnout and learning that rest isn't a dirty wordDefensiveness as a sign we don't feel safe and why we need an embodied sense of safetyWhat happens when you can't trust your bodyNot making change, but making change possibleShifting from “what's wrong with me” to friendly awarenessBonus: Nervous System Exercise with Kelly LubeckWe do regular nervous system regulation in FLOW365, and we've include an exercise with our teacher Kelly Lubeck.ABOUT HEIDIHeidi Fischbach is a nervous system coach and an award-winning (featured) speaker who has facilitated body-based transformation and healing for tens of hundreds of clients and students.Heidi has developed a unique science-backed and body-based program to help her clients reset stress- and trauma-based patterns of coping so that they can feel safe and at home in their bodies and meaningfully connected to themselves and what matters to them.Heidi brings decades of therapeutic massage and Focusing experience, which she combines with a Polyvagal Theory-informed understanding of the nervous system. As a result of Heidi's Nervous System Reset Program, women are able to lay down new neural pathways which allow them to transform anxiety into calm and meaningful connection.ABOUT KELLYKelly Lubeck, MPH, is passionate about changing the world for the better, through individual and community-level healing programs that inspire wellness, health and soul- centered, embodied leadership. Kelly guides changemakers and leaders to heal their individual nervous systems and release self- defeating patterns of self-sacrifice and overgiving in their work and relationships that lead to burnout, anxiety and illness. Kelly is currently a teacher in FLOW365.LINKShttps://heidifischbach.com/5 Steps Back to Calmhttps://www.youtube.com/@HeidistableReadySetPause Facebook groupFLOW365DOABLE CHANGESAt the end of every episode, we share three doable changes, so you can take what you've heard and put it into action. Action is where change happens.Even though we want big change, it's really little things done over and over that make the difference. So pick a doable thing. Put it in your calendar. Weave it through your days for a week and then move on to the next one. It will...
Jede vierte Frau fühlt sich beim Sex in ihrem Körper unwohl. Jeder Dritte würde gerne häufiger leidenschaftlich küssen, ohne gleich Sex zu haben. Und bei den Jüngeren hat jeder vierte die Sorge, den Partner sexuell nicht zufrieden zu stellen. Das sind Zahlen, die die Psychologin und Paarberaterin Lisa Fischbach in Studien für ein Partnerschaftsportal ermittelt hat. Von Katrin Schüßler.
Bigger is better: Warum Lukas Heise gerne die eierlegende Wollmilchsau ist Die Fischbach Gruppe ist ein All in One Dienstleister in Sachen Bauen im Bestand. Nun wagt sich der Generalunternehmer an das Giga-Wohnungsbauprojekt „Hannibal II“. Die Themen des DW Podcast mit Lukas Heise im Überblick: (00:00) Einleitung (03:44) Wie aus 750.000 Euro Umsatz 150 Millionen Euro wurden (14:57) Weshalb sich die Politik auch mal was trauen muss (21:10) Wie innovativ die Fischbach Gruppe wirklich ist (29:17) Warum Lukas keine Angst vor Hannibal hat Wenn Euch diese Podcastfolge gefallen hat, freuen uns, wenn Ihr uns eine gute Bewertung da lasst! Oder checkt unsere anderen Kanäle aus! WEBSEITE: https://www.digitalwerk.io/ INSTAGRAM: https://www.instagram.com/digitalwerk.io/ LINKEDIN: https://www.linkedin.com/company/digitalwerk-io/ YOUTUBE: https://www.youtube.com/channel/UCnZGli0DQoayTv8xJe64nWQ
The Matt McNeil Show - AM950 The Progressive Voice of Minnesota
Severe weather slams the Midwest this weekend; Jerry Seinfeld’s opinion on current comedy; Kristi Noem’s bad weekend; Michael Brodkorb discusses the Nicole Mitchell situation; Fischbach not endorsed; Feeding Our Future trials begin.
Enrollment closes soon for Ari's Take Academy! Save 10% with code NMB and enroll: https://aristakeacademy.com/A Los Angeles native and UCLA alumni, Michele Harrison commenced her career as a legal assistant at the Law Offices of Fischbach, Perlstein and Lieberman. Following gigs at Virgin Records and Hollywood Records, she spent 15 years at Ian Montone's Monotone, Inc., working with the likes of Broken Bells, The Shins, Vampire Weekend, and Academy® Award winner Jamie Foxx. In 2018, she became Co-Head of Management at Friends At Work, managing Alanis Morissette and Raphael Saadiq. 2021 saw her join Range Music as a Partner, overseeing the careers of Healy, KaiGoinKrazy, Tkay Maidza, Justin Tranter, and UMI. With MPH Collective, she has now built a haven for artists, visionaries, and storytellers to shine without compromise.In this interview, Ari and Michele discuss the role of autonomy and control in management, the impact of TikTok on artists' careers, and the changing landscape of record deals. She shares insights into the profitability of different venue sizes and the revenue streams from touring, including VIP experiences and merchandise sales. Michele also discusses the role of producers and the process of creating beat packs to pitch to artists and songwriters. She highlights the importance of getting in the room with other producers and songwriters to create music.Chapters00:00 Introduction and Background of MPH Collective03:06 The Impact of TikTok and Challenges in the Music Industry06:53 The Shifting Landscape of Record Deals11:52 The Importance of Authenticity in Social Media30:26 Building a Collaborative Team35:15 The Importance of Booking Agents and Touring41:09 Profitability and Revenue Streams46:09 The Role of Producers57:01 The Goal in the New Music BusinessSubscribe to The New Music Business: https://aristake.com/new-music-business-podcast/Ari's Take Academy: https://aristakeacademy.comWatch more discussions like this: https://bit.ly/3LavMpaConnect with Ari's Take:Website: https://aristake.comInstagram: https://www.instagram.com/aristake_TikTok: https://www.tiktok.com/@aris.takeX: https://twitter.com/ArisTakeThreads: https://www.threads.net/@aristake_YouTube: https://www.youtube.com/user/aristake1Connect with Ari Herstand:Website: https://ariherstand.comInstagram: https://instagram.com/ariherstandX: https://twitter.com/ariherstandYouTube: https://youtube.com/ariherstandConnect with Michele Harrison:Linkedin: https://www.linkedin.com/in/michele-harrison-88315a18/Instagram: https://www.instagram.com/mphcollective/Edited and mixed by Ari DavidsMusic by Brassroots DistrictProduced by the team at Ari's Take Hosted on Acast. See acast.com/privacy for more information.
Don't miss The Victory Hour with Andrew Parker and his special guest Minnesota Congresswoman Michelle Fischbach as they discuss spending money in DC like never before. Support the show
The “meet the growers” section on the American Hazelnut Company website reads, We are not young. We have planted hazelnuts that will outlive us, growing old with our children and […] The post Hazelnut in Wisconsin with Jason Fischbach and Paul Ronsheim appeared first on WORT-FM 89.9.
We're joined by Yannick Fischbach, a professional triathlete from Greenville, South Carolina! After placing in his first triathlon and qualifying for Boston in his first marathon, Yannick realized he might have a knack for this. In this episode, we discuss his journey to finding triathlon after college soccer, the difference between amateur and elite level mindset, the sacrifices that come with the sport, and much much more. Get in touch in the comments below or head to… Yannick's Instagram: @alldayidreamaboutit | @swim.bike.run.allday Ryan's Instagram: @ryanejezie | @eazy.community Ryan's website: eazyliving.net
Charlene talks with Jeremy Fischbach, founder and Chief Executive Officer of Happy, a peer-based mental health service whose mission is to create a more supportive culture by expanding access to mental health care and teaching and inspiring people to better emotionally support each other. Charlene and Jeremy talk about Happy's unique proactive outreach approach and the importance of getting mental health support to those who need it without waiting for them to seek it out on their own. Host: Charlene Platon, MS, RN, FNP-BC (@charleneplaton) Guest: Jeremy Fischbach (happythemovement.com) About the show: ACNL in Action is a production of the Association of California Nurse Leaders, the professional organization for nurse leaders. New episodes come out on the first Friday of every month. Want to support ACNL? Consider making a donation: http://bit.ly/cog-podcast . Learn more about ACNL, including how to become a member, at acnl.org. Follow us on Facebook and LinkedIn at @acnlnurse.
We are back to close out 2023 and continuing our discussions on Palestine, this time through the prism of the Civil Rights struggle in the United States. Professor Michael Fishbach joins us to discuss his 2019 book Black Power and Palestine: Transnational Countries of Color. Professor Fishbach chronicles how Black Power activists and others in the Civil Rights struggle came to see Palestinians as a kindred people of color, waging the same struggle for freedom and justice as themselves. He brings his meticulous research to bear for a fascinating conversation about the Palestinian conflict's role in Black activism and the ways that the struggle shaped the domestic fight for racial equality, deeply affected U.S. black politics, and animating black visions of identity well into the late 1970s. About Dr. Michael Fischach Michael R. Fischbach is professor of history at Randolph-Macon College. Dr. Fischbach holds a PhD in History from Georgetown, MA in Arab Studies from Georgetown, and a BA in History from Northwestern University. He specializes in land issues relating to Israel, Jordan, and the Palestinians and is the author of State, Society, and Land in Jordan, Records of Dispossession: Palestinian Refugee Property and the Arab-Israeli Conflict, Jewish Property Claims Against Arab Countries, The Peace Process and Palestinian Refugee Claims: Addressing Claims for Property Compensation and Restitution, and two related works The Movement and the Middle East: How the Arab-Israeli Conflict Divided the American Left, and the book we discussed: Black Power and Palestine: Transnational Countries of Color.
Professor Michael Fischbach, tells us that the “gut biome” – that is, the complex community of bacteria that lives in our gastrointestinal tract – is what makes digesting and extracting nutrients from those meals possible. We hope you'll tune in.Contact Links:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads or Twitter/XConnect with School of Engineering >>> Twitter/XChapters:(00:00:00) Introduction to Microbiome: A PrimerHost Russ Altman introduces the episode and its focus on the gut biome with guest Professor Michael Fischbach. Russ discusses the importance of bacteria & the influence of diet on maintaining a healthy microbiome, specifically yogurt(00:04:08) The Role of BacteriaAn explanation of how bacteria are utilized by our body for digestion(00:06:16) Antibiotics and Gut Microbiome DisruptionThe repercussions of antibiotic use on the gut microbiome's composition and its effects on digestion.(00:07:14) Bacterial Chemicals in the BodyA detailed explanation of how bacteria create chemicals that enter the bloodstream & example of one of these chemicals, of TMAO (trimethylamine N oxide) and its connection to heart disease risk. (00:09:48) Vegans and TMAOInsight into a study involving vegans and their lack of TMAO production due to the absence of specific gut bacteria & its implications.(00:12:31) Bacteria's Use of Chemicals for SurvivalDr. Fischbach explains how bacteria utilize chemicals in food due to the absence of oxygen in the gut. The concept of electrons and their role in bacterial survival.(00:14:17) Microbial CommunitiesDiscussion on manipulating microbial communities and the challenges associated with making precise changes. (00:15:22) Fecal Transplants and Community DynamicsInsight into the success of fecal transplants in treating gut infections. Understanding the dynamics of microbial communities and their role in combating infections.(00:18:30) Building Complex Microbial CommunitiesExploring efforts to construct diverse communities and the stability of ecosystems. Early observations on the interactions between various bacterial species in complex communities(00:21:16) Precision Fecal TransplantsDiscussion on the limitations of fecal transplants and the need and potential for precision in microbial composition for treating diseases. (00:22:29) Microbiome Diagnostics for Disease DetectionThe potential of microbiome analysis as a diagnostic tool for diseases like Crohn's, based on differences in gut community rosters. The debate around whether changes in the microbiome precede or result from diseases, as well as genetic & environmental factors.(00:25:39) Fermented Foods and Microbiome ImpactDiscussion on the potential health benefits of fermented foods and predictions about future interventions involving bacteria (00:26:29) Microbiome and Aging EffectsEarly research on the impact of aging on the microbiome and the potential for programmed microbiome composition at different life stages. Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads or Twitter/XConnect with School of Engineering >>> Twitter/X
Drs. Diwakar Davar and Ben Boursi discuss the role of the gut microbiome in the outcome of cancer immunotherapy and the prevention of immunotherapy-related adverse events, as well as compelling research on nutritional interventions to improve response to immune checkpoint inhibitors. TRANSCRIPT Dr. Diwakar Davar: Hello, and welcome to the ASCO Daily News Podcast. I'm your guest host, Dr. Diwakar Davar. I'm an associate professor of medicine and the clinical director of the Melanoma and Skin Cancer Program at the University of Pittsburgh's Hillman Cancer Center. Researchers have shown that microorganisms in the gut can impact the effectiveness of immunogenic chemotherapy for patients with cancer. Although microbial therapies for cancer are still at a very early stage of clinical development, compelling research in recent years has shown that changing the gut microbiome can help improve outcomes in patients receiving treatments for cancer enduring immune checkpoint inhibition. My guest today is Dr. Ben Boursi, a GI medical oncologist at the Sheba Medical Center at Tel Aviv University in Israel. Dr. Boursi is also an adjunct professor at the Center for Clinical Epidemiology and Biostatistics at the University of Pennsylvania. He joins me today to discuss his pivotal research on the role of the gut microbiome in mediating its effects on immunotherapy. And again, I want to highlight that we're recording this on October 9th, and as you may well know, many recent events over the last couple of days have happened in Israel, and so Dr. Boursi has joined us at a very difficult time. So, we're very grateful for him taking time out of his suddenly very busy schedule to join us at a time that is fraught for all. You'll find our disclosures in the transcript of this episode. You'll also find the disclosures of all guests on the podcast at asco.org/DNpod. Ben, it's great to have you on the podcast today. Thank you for being here at such a difficult time, sharing what will, I think, be a great episode. Dr. Ben Boursi: Thanks for having me, Diwakar. Dr. Diwakar Davar: Ben, the gut microbiome and its role in terms of mediating effects and side effects of cancer immunotherapy has gotten a lot of interest recently. You've done some fundamental work in this space. Why don't you briefly summarize for the audience, firstly, what is the gut microbiome and what are the major themes in relation to cancer immunotherapy? Dr. Ben Boursi: Well, the microbiome is the ecosystem of microorganisms, bacteria, phages, fungi, that are crucial for immunologic, metabolic and hormonal homeostasis of the host. In the last decade, we began to understand the central role of the gut and tumor microbiome in tumorigenesis, metastasis, treatment efficacy and toxicities, and in 2022, polymorphic microbiomes became one of the hallmarks of cancer, in addition to previous hallmarks that focused mainly at the cellular/genetic levels. The initial studies in mice models showed that therapeutic efficacy of immunotherapy depends on both the presence and composition of the microbiota (In germ-free or antibiotic treated mice, immunotherapy is ineffective), and following these studies, three observational studies in human patients showed that the gut microbiome can predict response to immunotherapy and that response to immunotherapy could be transferred to germ-free mice by fecal microbiota transplantation (FMT) from responding patients. These studies helped us to define three main research questions regarding the possible role of microbial modulation in cancer treatment. First, can microbial modulation overcome resistance to immunotherapy, both primary and secondary resistance? And this question was the focus of the initial proof of concept studies. Second, can microbial modulation improve response to immunotherapy in treatment-naive patients? And third, can microbial modulation prevent or treat immune related adverse events? The initial positive results of clinical trials also led to additional questions. For example, can microbial modulation induce anti-tumor immune response even in non-immunogenic tumors? And it is important to note that there are many ways to modulate the microbiota, but so far, the only reliable way that showed positive results is fecal microbiota transplantation that allows the transfer of the entire microbiota both in terms of composition and relative abundance. Dr. Diwakar Davar: That's great. Essentially with the trials that I think the data sets that you're referencing of course, are papers by Jennifer Wargo, Thomas Gajewski, and Lawrence Zitvogel, looking at the role of gut microbiota in several different cancers, primarily immune checkpoint sensitive tumors such as melanoma, non-small cell lung cancer and kidney cancer. And then the work from several different groups showing that essentially proof of concept experiments can be done to try to change this, certainly preclinically, and now we know that that can be done clinically. So, I guess the failure rates of immunotherapy in some patients are quite high. And we know that the microbial composition can change the likelihood to respond to immunotherapy based on all these trials. And actually, even going back to 2015, we had two seminal papers that looked at the role of CTLA-4 blockade as well. But subsequently, many years after that, 7 years after 2015, and certainly 3 years after 2018, when the three observational PD-1 papers were published, there were 2 pivotal trials in PD-1 advanced or refractory melanoma. They demonstrated that changing the gut microbiome can reprogram the immune system to attack tumors. So, there were 2 separate trials, both published the same issue of Science. One trial was led by your group at Sheba, and another one's led by us, the University of Pittsburgh. Why don't you summarize both studies for our audience. Dr. Ben Boursi: So, both studies were Phase I clinical trials of FMT in metastatic melanoma patients who failed immunotherapy. Recipients were metastatic melanoma patients that progressed on at least one line of anti PD-1 and in BRAF mutated patients, BRAF inhibitors as well. Donors in the Sheba study were metastatic melanoma patients with durable complete responses to immunotherapy for at least one year, and in the Pittsburgh study, you also included patients with durable partial responses of more than two years as donors. It is important to note that each fecal transplant in both studies was composed of a single donor. Prior to transplantation, we performed a microbiome depletion phase using a combination of two antibiotics, vancomycin and neomycin. The goal of this phase was to assist in engraftment (by avoiding colonization-resistance by recipient bacteria) and to “reset” the immune system, which may remind some people of the logic behind bone marrow transplantation. In the Pittsburgh study, there was no bacterial eradication with antibiotics, mainly because of studies showing that response to immunotherapy is lower following antibiotic treatment. Both studies performed FMT through colonoscopy. At Sheba, we also performed maintenance FMT using capsules in order to keep the donor's microbial composition. After the initial FMT, both studies reintroduced the same immunotherapy in which the patient progressed in the past. Clinically, we have seen a 30% response rate with durable, complete and partial responses, and in the Pittsburgh study, there was a 20% response rate and 40% disease control rate. Both studies showed following FMT, immune response in the gut and in the tumor, and tumors that were immune deserts prior to FMT became infiltrated with lymphocytes. Interestingly, in our study, there were no moderate to severe immune related adverse events following FMT and reintroduction of immunotherapy. And this is despite the fact that five of the patients had significant side effects during previous rounds of the same immunotherapy. Dr. Diwakar Davar: So essentially, in these very early proof of concept studies, what I think is pretty remarkable is that obviously the sample sizes were very small, but remarkably, patients that appeared to respond, responded in a setting in which they were not expected to respond. So, the probability of a patient responding to attempt at giving PD-1 in patients who were PD-1 relapse refractory is on the order of about 7%, based on an FDA analysis by Viva et al. And here, two separate studies, two independent studies, investigators had not known that each paper was being published, remarkably similar results clearly demonstrating that this is perhaps one of the best pieces of evidence to suggest that microbiome modulation may actually truly be effective in reversing PD-1 refractoriness. More recently, our colleague Dr. Bertrand Routy at University of Montreal has done a proof of concept trial in evaluating the use of healthy donor fecal microbiota transplant in addition to anti PD-1 monotherapy in PD-1 naive metastatic melanoma. In this study, published in Nature Medicine a few weeks ago, his group reported an objective response rate of 65%. What are your thoughts about this study? And specifically, what are your thoughts about some of the pharmacodynamic and translational results that were demonstrated? Dr. Ben Boursi: This is a very interesting question, because in both the Sheba and the University of Pittsburgh studies we chose responding patients as donors. We thought that by using these patients, we provide beneficial bacteria that enhance responses to immunotherapy through several mechanisms (molecular mimicry, immunomodulatory bacterial metabolites, modulation of immune checkpoint expression, and much more), and here in the Routy paper, the researchers used FMT from healthy donors without any selection for specific beneficial bacteria, and they demonstrated a similar effect on overall response rate. So maybe FMT works actually through reducing colonization by deleterious bacteria? Another question that we should ask is whether we need to choose donors differently when we use microbial modulation in treatment resistant patients compared to treatment-naive patients? Moreover, a previous meta-analysis of FMT studies across indications that was conducted by the group of Dr. Nicola Segata, demonstrated that recipients with better engraftment were more likely to experience clinical benefit, and that increased engraftment was mainly observed in individuals receiving FMTs through multiple routes, colonoscopy and capsules, as well as recipients that received antibiotics prior to FMT. But in Routy's trial, they not only used healthy donors, they performed bacterial cleansing only prior to FMT instead of bacterial eradication with antibiotics, and used FMTs through colonoscopy only, and they didn't give maintenance FMT. Of course, such an approach is much more feasible in the clinical setting and is relevant for designing future clinical trials. Dr. Diwakar Davar: So, many differences, relatively few similarities, but I guess one interesting point is that of engraftment, which is that in your paper, our paper, and certainly in Bertrand's paper, it is very interesting that engraftment appears to be a key pharmacodynamic biomarker of microbiome modulation. And certainly, the analogy that you used earlier, which is that it's very similar to what happens in a stem cell transplant, which is that if there's no take, there's probably not going to be any effect. So that's very interesting that engraftment is emerging as a key PD biomarker of essentially the success of any kind of microbiome modulation across multiple different settings. Now, we've heard of certainly defined microbial consortia, of cultivated species, as an alternative gut microbiome modulation strategy that balances the benefits of the ecological complexity of FMT with the scalability and practicality of probiotics. Do you think we are ready to design consortia? Dr. Ben Boursi: So to date there are several probiotics that use a single bacteria and several microbial consortia that were evaluated in clinical trials, and as you mentioned, they may offer more tractable solutions for widespread clinical use. If we begin with the single bacteria probiotics, two phase 2 clinical trials found that administration of the butyrate producing probiotic clostridium butyricum 588 (CBM588) to immunotherapy naive patients with metastatic renal cell carcinoma led to markedly better immunotherapy responses, although the probiotic had a minimal effect on the composition of the microbiota, and the control arm of the trial responded worse than expected. In addition, in preclinical studies, probiotic strains of lactobacillus and bifidobacterium have been shown to enhance immune control of transplanted tumors and to augment anti PD-1 activity. However, a clinical trial in patients with metastatic melanoma found that the use of lactobacillus or bifidobacterium probiotics was associated with reduced microbiota diversity and worse responses to anti PD-1. So here the conclusion is that when we try to design probiotics, we should not focus only on the composition since other factors, such as the relative abundance also matter. Too much of a beneficial bacterial species may potentially be worse than having a balanced and diverse microbiota. For example, a recent study of patients with non-small cell lung cancer receiving immunotherapy found that patients with a detectable Akkermansia muciniphila in their gut microbiota (this is a beneficial bacteria) responded well to treatment, but those with relative abundance of Akkermansia muciniphila greater than 5% responded worse than patients lacking Akkermansia, and this is due to the mucolytic effect of the bacteria. So, the use of rationally designed consortia may be better than a single probiotic strain. And there are currently 3 main microbial consortia that are being evaluated: the SER-401, a bacterial consortium enriched with clostridium, led in a randomized controlled trial to reduced response to immunotherapy compared to placebo control in first line metastatic melanoma patients, potentially due to a confounding effect of a vancomycin pretreatment; MET4 is a 30 bacteria consortium that was shown to be safe and to alter the gut microbiota and serum metabolome of immunotherapy naive patients. Here, the initial study was underpowered to determine the effect on treatment efficacy; And finally, VE800 is an immunotherapy enhancing 11-bacterial consortium that is currently being evaluated in phase 1 and 2 clinical trials, and we are looking forward to see the results with this agent. Dr. Diwakar Davar: So I guess where we are right now is that social design is clearly difficult because of all the reasons you've mentioned. The SER-401 data and the MET4-IO trials certainly give us pause for thought. Certainly, no pharmacodynamic changes that were seen with SER-401, MET4-IO did result in pharmacodynamic shifts metagenomically, but neither trial was positive. And certainly, the VE800 trial, which has been ongoing now for several years, and the lack of publicly reported data certainly doesn't suggest that there's a huge efficacy signal. So consortias, at least at this point, certainly do not appear to be having a significant effect, though we don't know what might happen in the future. Data from multiple groups has shown that gut microbial composition influences the development of immune related adverse events (irAEs) in both PD-1 and combination PD-1 and CTLA-4 treated patients. Unsurprisingly, as a result, there have been attempts made at evaluating the role of fecal microbiota transplants to treat refractory immune related adverse events and very specifically immune checkpoint associated colitis or IMC. So, Dr. Yinghong Wang, who is the chair of the Immunotherapy Toxicity Working Group at the University of Texas MD Anderson Cancer Center has been very prominent in this space, and in a recent paper published in Science Translational Medicine, which is a follow up paper to her early work in Nature Medicine, she reported that HDFMT, healthy donor fecal transplantation, was very efficacious in feeding early refractory immune checkpoint colitis. So, what are your thoughts on this approach and how important is this space and where else might it be efficacious? Dr. Ben Boursi: When I talked about the Sheba clinical study, I mentioned the possible role for microbiota modulation in the prevention of immunotherapy related adverse events in general, not only colitis. But the study by Dr. Yinghong showed that FMT can actually treat immune-related colitis refractory to steroids and anti-TNF. Now, this approach is probably relevant not only for immune related colitis, but also to other immune related adverse events. We can define certain bacterial species that may be associated with different immune related events. For example, streptococci can be associated with immune related arthritis. And maybe in the future we won't need to use FMT, but we will rather be able to target these specific immunogenic strains by narrow spectrum antibiotics or phages. The main challenge would be to develop microbiotic targeting interventions that reduce immune related adverse events without compromising therapeutic efficacy. Now, is microbial modulation relevant only for toxicity from immune checkpoint inhibitors? So, the answer is ‘no'. We know mainly from animal models of hematopoietic cell transplantation, CAR T, and immune agonist antibodies that antibiotic-treated or germ-free mice have markedly reduced immunotoxicity, such as graft versus host disease, cytokine release syndromes, and more. It is also worth mentioning that microbial modulation is relevant not only for reducing toxicity from immunotherapy, but also from chemotherapy and other anticancer modalities. And the best example is the gastrointestinal toxicity of irinotecan that is mediated by the bacterial beta-glucuronidase. And here the targeting may even be a bit less complex. Dr. Diwakar Davar: So, what we take away from that is that starting with actually your paper originally, and papers to be produced, immune-related adverse events can be prevented using microbiome modulation with FMT, and Dr. Wang's data suggesting that eventually FMT can be used to eradicate highly refractive colitis, again, this is important to keep in mind that this approach is not yet FDA-approved. It's being done under IND. It's not currently something that is a certain standard of care. One interesting area of drug development is that there's a French microbiome company named MaaT Pharma where they have an agent that is a very interestingly a pooled microbiome product from multiple different donors. Again, the trials in both Israel and Pittsburgh used individual donors. This is a pooled donor construct. The lead candidate is actually graft versus host disease. The trial is the ARES trial, A-R-E-S, as in the Roman god of war. This trial is actually ongoing in Europe, and I believe there's some effort to try to see whether or not it's going to be a trial that can be done in the United States as well. So, at this point in time, again, we don't know whether or not there are any developmental approaches from a pharmaceutical company in the United States, but certainly this is definitely an area of interest. So microbial therapies are still relatively early. It's going to be interesting to see how the advanced field of nutritional interventions provide an appealing method for modulating the gut microbiome due to the excellent safety profile, cost effectiveness and noninvasiveness. And certainly, if you are what you eat and your bacteria are what they eat, which goes down to our diet, there's enough rationale to believe that certain nutritional interventions can have an effect via the intermedial gut microbiota modulation. Holistic dietary changes and or supplementation specific nutrients such as prebiotics could therefore be utilized to specifically shape the population of beneficial microbes and shift the immune microbiota landscape. Now, we have seen in data published by several of our colleagues that in patients with cancer, high fiber intake is associated with greater microbial diversity, greater abundance in fiber fermenting microbes such as members of the Ruminococcaceae family, and these are all associated with the response to checkpoint inhibitor therapy. So, what do you think about nutritional interventions? Do you want us to briefly summarize data regarding nutritional data and where it stands in cancer at his time? And can you speculate as to how effective this might be in the context of patients with cancer? Dr. Ben Boursi: So, let's begin with diet. A growing number of clinical and preclinical studies suggest that specific dietary interventions such as a high fiber diet can not only improve response to immune checkpoint blockers, but also reduce immunotoxicity such as graft versus host disease. And there are many other diets that are being tested such as ketogenic diets and intermittent fasting. And the effects of diet may be mediated by both microbiota-dependent and microbiota-independent mechanisms. The limitation of this approach is that changes to the microbiota induced by diet are generally quite variable between patients and can depend on an individual's microbiota prior to intervention. And patient compliance is also a concern, particularly in the very strict diets. Now, regarding high fiber diets, several large cohorts of melanoma patients from the US, Australia, and the Netherlands demonstrated how a high fiber diet modulates the microbiome and results in a better response to immunotherapy, better progression-free survival. Additional studies that were presented at AACR in 2023 showed that high fiber dietary interventions, in which patients received a fiber-enriched diet for six weeks, was feasible and that the high fiber diet resulted in a rapid shift in the gut microbiota toward fiber-responsive short chain fatty acid-producing taxa and a shift of the metabolome, with increase in the short chain fatty acid acetate, Omega-3, Omega-6, polyunsaturated fatty acid, and tryptophan metabolites. Prebiotics can also promote the growth of beneficial microbial species in the gut by providing targeted nutrition. And one example of a prebiotic that was shown to enhance immunotherapy efficacy in mouse models is castalagin, which is isolated from the camu-camu berry. Castalagin directly binds the outer membrane of ruminococci and promotes their growth, which has been shown to increase the CD8-positive T-cell activity and anti-PD-1 efficacy. Now, since prebiotics rely on the presence of beneficial taxa already in the host microbiota, symbiotics, which refers to the administration of the appropriate prebiotic and probiotic together, may prove in the future to be more effective than using either separately. Dr. Diwakar Davar: Certainly, these dietary interventions can be very exciting and certainly we do know of several colleagues who are doing these diet interventions, though compliance with any kind of dietary intervention may be a challenge that decides how effective such an approach is going to be. So microbial therapies in general are still at a relatively early stage of development. And it'll be exciting to see how they advance. What approaches are you excited about? What is on your radar? Dr. Ben Boursi: There are many exciting works that are currently ongoing, and to emphasize just a few: there are many clinical trials in immunogenic tumors, in addition to melanoma, for example, renal cell carcinoma, and non-small cell lung cancer, that also evaluate different modulation protocols. We should remember that one size does not fit all, and different tumors have different microbiomes. We have a project in collaboration with MD Anderson in MSI-high patients with exciting initial results. Another study that was initiated at Sheba is using microbial modulation in order to improve TIL therapy (to overcome resistance to TIL and T-cell exhaustion). There are also studies that try to change the pharmaco-microbiome, for example, to eradicate bacteria that inactivates the chemotherapy agent, gemcitabine, in pancreatic cancer patients. And there are groups that try to identify recipients that will respond to microbial modulation and to generate better donor-recipient matching algorithms. There are already signatures like TOPOSCORE that was presented at ASCO 2023 that try to predict response to immunotherapies through the ratio between harmful and beneficial bacteria. Now, there's also more basic science work, for example, bacterial engineering. There was a wonderful study from the Fischbach group in Stanford that demonstrated how Staphylococcus epidermidis engineered to express melanoma tumor antigens was able to generate a systemic tumor-specific response in mice models when applied topically; functional imaging of the microbiome, for example, FDG uptake in the colon can reflect microbial diversity and response to immunotherapy; works that characterizes other microbiomes such as the urinary and skin microbiomes, and their interaction with the gut microbiome; and studies of the nonbacterial component of the microbiome, mainly phages and fungi. But for me, the most important word should probably be collaboration, because without joining forces internationally, we won't be able to understand the human metaorganism, the variations according to geography, ethnicity, lifestyle, diets, and much more in the microbiome. And this is crucial in order to really understand the complex tumor ecological niche within the human host. Dr. Diwakar Davar: I think one of the key points that you just mentioned is collaboration. That's going to be very, very critical as we move this forward for many reasons, including the unexpected impact of geography upon the composition of the gut microbiome in work that has been published by many groups, but also including ours in a paper that we published about a year ago now. So, Dr. Boursi, thank you for your great work in this area. Thank you for sharing your insights with us today on the ASCO Daily News Podcast. This is a very difficult time for all of you and your colleagues in Israel, and we thank you so much for taking such a great deal of time out of your busy workday to spend some time with us. Dr. Ben Boursi: Thank you very much. Dr. Diwakar Davar: Thank you to all our listeners today. This is a very exciting area. This is an area where we are discovering more every day than we knew just up until the day prior. You will find the links to the studies that were discussed today in the transcript of this episode. Finally, if you value the insights that you hear on the ASCO Daily News Podcast, please take the time to rate, review, and subscribe wherever you get your podcast. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guests' statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Follow today's speakers: Dr. Diwakar Davar Dr. Ben Boursi Follow ASCO on social media: @ASCO on Twitter ASCO on Facebook ASCO on LinkedIn Disclosures: Dr. Diwakar Davar: Honoraria: Merck, Tesaro, Array BioPharma, Immunocore, Instil Bio, Vedanta Biosciences Consulting or Advisory Role: Instil Bio, Vedanta Biosciences Consulting or Advisory Role (Immediate family member): Shionogi Research Funding: Merck, Checkmate Pharmaceuticals, CellSight Technologies, GSK, Merck, Arvus Biosciences, Arcus Biosciences Research Funding (Inst.): Zucero Therapeutics Patents, Royalties, Other Intellectual Property: Application No.: 63/124,231 Title: COMPOSITIONS AND METHODS FOR TREATING CANCER Applicant: University of Pittsburgh–Of the Commonwealth System of Higher Education Inventors: Diwakar Davar Filing Date: December 11, 2020 Country: United States MCC Reference: 10504-059PV1 Your Reference: 05545; and Application No.: 63/208,719 Enteric Microbiotype Signatures of Immune-related Adverse Events and Response in Relation to Anti-PD-1 Immunotherapy Dr. Ben Boursi: No relationships to disclose.
Will Fischbach and I spent nearly 80 minutes talking about his life, schooling, his time as an Army JAG, private practice, and public service. While editing of our conversation I came to realize the relevance of everything we discussed: Will's willingness to do anything that he was asked to do in the Army has shaped his approach to private practice in Phoenix, AZ; he is an attorney who is not afraid to take on various types of cases. --- Support this podcast: https://podcasters.spotify.com/pod/show/tom-welsh/support
15:24 - Congresswoman Michelle Fischbach - Minnesota's 7th Congressional District 1:10:42 - John Hinderaker - Center of the American Experiment 1:16:56 - Congressman Kelly Armstrong - North Dakota Congressman 2:01:35 - Jim the Flagpole Guy What's on your mind? We want to know! Email us at StudioFlagFamily [dot] com Subscribe on Spotify, Apple, & Google
This is Garrison Hardie with your CrossPolitic Daily News Brief for Tuesday, June 27th, 2023. Fight Laugh Feast Conference - Ark Encounter This year, our Fight Laugh Feast Conference is at the Ark Encounter in Kentucky on The Politics of Six Day Creation. The politics of six day creation is the difference between a fixed standard of justice and a careening standard of justice, the difference between the corrosive relativism that creates mobs and anarchy and the freedom of objectivity, truth, and due process. The politics of six day creation establishes the authority and sufficiency of God’s Word for all of life: from what is a man or a woman, when does human life begin, and how is human society best organized? Come hear Ken Ham, Pastor Doug Wilson, Dr. Ben Merkle, Dr. Gordon Wilson, me and more, and of course a live CrossPolitic show! Mark your calendars for October 11th-14th, as we fight, laugh, and feast, with beer & psalms, our amazing lineup of speakers, our Rowdy Christian Merch, and a Sabbath Feast to wrap up the occasion. Maybe an infant baptism while we’re at it! Visit fightlaughfeast.com for more information! https://justthenews.com/politics-policy/anniversary-roe-v-wade-being-overturned-gop-rep-promotes-bill-help-expectant On anniversary of Roe v. Wade being overturned, GOP Rep. promotes bill to help expectant mothers On the anniversary of Roe v. Wade being overturned, Minnesota Republican Congresswoman Michelle Fischbach promoted a proposed bill titled "The HOPE Act" that promotes helping expectant mothers. "It is crucial that women are supported when facing an unexpected pregnancy, which is why I have introduced The Health, Opportunity, Protecting Life, Education (HOPE) Act, which improves access to prenatal telehealth care, supports positive alternatives to abortion, and improves access to information for expectant mothers, providing tangible ways to help women feel confident during and beyond their pregnancy," Fischbach wrote in an opinion piece published by The Hill. On June 24, 2022, the Supreme Court of the United States ruled to overturn Roe v. Wade, ending the constitutional right to abortion and allowing individual states to decide for themselves on whether to restrict or allow abortions. The HOPE Act would provide funding for grants and other activities related to maternal care. It would also establish informed consent and parental notification requirements for abortion providers. "The HOPE Act creates a pilot grant program to provide support and equipment like blood pressure monitors, scales, and portable fetal heart rate monitors to community health providers," Fischbach wrote. "Increasing telehealth options gives expectant mothers the flexibility they need to receive the care they deserve." It would also prohibit any government funding going to Planned Parenthood. https://www.foxnews.com/media/bud-light-sponsors-toronto-pride-parade-naked-men-children Bud Light sponsors Toronto Pride parade attended by naked men, children Bud Light is serving as an official sponsor of the Toronto Pride parade, where video footage shows naked men standing around and riding bicycles in clear view of children attending the event. The footage, captured by Beth Baisch of the Post Millennial, shows dozens of attendees riding past a large cheering crowd. The fully naked bikers, some covered in paint or tattoos, wave back at the crowd. One naked man high-fives an onlooker while another peddles a recumbent bike with a gold blow-up swan adorned around his neck. A second video shows a group of naked men with hats standing in a circle amidst the crowd. Several children walk past the group of men with their families. Another clip shows a person wearing a giant penis costume that covers his entire head. The camera captures a young girl sitting in a stroller and staring toward the phallic-costumed individual. Other videos show a group of naked men playing and rinsing themselves off alongside a fountain surrounded by kids. Meanwhile, a stage, clearly adorned with Bud Light branding, featured scantily clad dancers wearing fishnets, nipple stickers and strange sock-like masks. The company's website notes that this year's sponsorship is representative of a longstanding partnership with the Pride event. "Bud Light Canada has been a proud partner of Pride Toronto for the last 10 years. This year, we're commemorating this milestone with Pride Toronto by featuring them on our can design, as well as continuing as the official beer sponsor of the festival," the beer brand's website states. According to the website, Bud Light Canada also provides $100,000 to various organizations that support the LGBTQUA2S+ community across Canada and has created a range of commemorative Pride beer cans to celebrate the collaboration. The partnership comes nearly three months after Bud Light received massive backlash for partnering with trans activist Dylan Mulvaney. The decision angered consumers and the brand saw a significant decrease in sales, resulting in billions of dollars in lost market value. In early April, Anheuser-Busch CEO Brendan Whitworth attempted to douse the flames with a lengthy statement to customers. "We never intended to be part of a discussion that divides people. We are in the business of bringing people together over a beer," he said in part. "My time serving this country taught me the importance of accountability and the values upon which America was founded: freedom, hard work and respect for one another. As CEO of Anheuser-Busch, I am focused on building and protecting our remarkable history and heritage." Despite losing business, Bud Light continued to anger customers for co-sponsoring an "all-ages Pride event" in Flagstaff, Arizona, on June 17. The party, called "Pride in the Pines," included drag queens and other performers, and listed Bud Light as one of the companies sponsoring the June 17 event. (Bud Light was initially mentioned prominently in one of the posters.) The event is listed as a "family festival event" and a family-friendly, "safe space" for all visitors. https://www.foxnews.com/us/colorado-springs-club-q-nonbinary-shooting-suspect-pleads-guilty-murder-charges Colorado Club Q 'nonbinary' shooter sentenced to life in prison after pleading guilty to murder Club Q shooting suspect Anderson Lee Aldrich was sentenced to life in prison after pleading guilty to murder and attempted murder charges during an arraignment hearing Monday morning, avoiding the prospect of a public trail just seven months after the deadly Colorado attack. Aldrich, who public defenders have said identifies as nonbinary and prefers to be described using they/them pronouns, is accused of fatally shooting five people and wounding 17 others at the LGBTQ+ nightclub Club Q in Colorado Springs, Colorado, on Nov. 19, 2022. The suspect, whom the judge referred to as "Mx. Aldrich" during Monday’s arraignment hearing, accepted a plea agreement for a life sentence without the possibility of parole in exchange for pleading guilty to five counts of first-degree murder. Aldrich also pleaded guilty Monday to 46 counts of attempted murder in the first degree. The suspect pleaded no contest to felony and misdemeanor charges of bias-motivated crimes. "Because of the evidence presented I believe there is a high probability of being convicted at trial to those counts, and so I am pleading no contest or nolo contendere," Aldrich told the court Monday, explaining the no contest plea. In an interview from jail, Aldrich reportedly admitted to The Associated Press to being on a "very large plethora of drugs" and abusing steroids at the time, expressing regret for the attack and adding that suggesting the shooting was motivated by hate was "completely off base." In court hearings earlier this year, law enforcement testified that Aldrich ran a neo-Nazi website and used gay and racial slurs while gaming online, while the defense countered that Aldrich's sometimes abusive mother forced the suspect to frequent LGBTQ+ clubs. Two veterans out at Club Q reportedly helped thwart the attack by disarming Aldrich, who was beaten by patrons and displayed a bruised and bloodied face in his initial mugshot and court appearance. Aldrich was facing more than 300 state counts, including murder and hate crimes. The Justice Department is also considering pursuing federal hate crime charges, according to a senior law enforcement official who spoke to the AP. However, the charges against Aldrich were thrown out in July 2022 after Aldrich's mother and grandparents, the victims in the case, refused to cooperate with prosecutors, evading efforts to serve them with subpoenas to testify, according to court documents unsealed after the shooting. Other relatives told a judge they feared Aldrich would hurt the grandparents if released, painting a picture of an isolated, violent person who did not have a job and was given $30,000 that was spent largely on the purchase of 3D printers to make guns, the records showed. Aldrich was released from jail then and authorities kept two guns -- a ghost gun pistol and an MM15 rifle – seized in the arrest. But there was nothing to stop Aldrich from legally purchasing more firearms, raising questions immediately after the shooting about whether authorities should have sought a red flag order to prevent such purchases. https://www.washingtonexaminer.com/news/nearly-half-bee-colonies-died-2023 Nearly half of honey bee colonies died in 2023 after three tumultuous years From April of last year to April of this year, 48% of honey bee colonies prematurely died off. University of Maryland and Auburn University have collaborated with nonprofit Bee Informed to track and report on managed bee colonies every year since 2007. Last year saw losses of 48%, the previous year’s loss was 39%, and the year before that, it was 50.8%. The average loss over the last 12 years is 39.6%. The cause of these losses is a mix of the parasitic mite, varroa destructor, which helps spread viruses between bees, increased use of pesticides, which inhibit the bee's ability to stave off diseases, and dramatic changes in the environment. When it becomes warmer than usual during the winter, bees will leave their colonies to begin pollinating many of the crops we eat, as well as other plants, but when the weather chills again, the bees die off. Still, the most commonly reported cause of death during the winter was the varroa. During the rest of the year, the most common report revolved around issues with the queen bee. "High levels of losses do not necessarily result in a decrease in the total number of colonies managed in the United States because beekeepers can replace lost colonies throughout the year," the report read. This report comes from a self-reported survey of 3,006 beekeepers from across the United States who collectively manage 314,360 colonies, the majority of which are commercially operated. This is only 12% of the estimated 2.70 million managed honey-producing colonies in the country in 2022, per the report. The collaboration, known as "the Bee Informed Partnership," is a non-profit organization dedicated to improving honey bee colony health in particular. https://www.conservativereview.com/unable-to-rely-on-wind-and-solar-sweden-ditches-100-renewable-target-and-bets-big-on-nuclear-power-2661896744.html Unable to rely on wind and solar, Sweden ditches 100% renewable target and bets big on nuclear power The Swedish parliament determined last week that in order to ensure the country has a "stable energy system," it will have to abandon its goal of "100 per cent renewable electricity production by 2040." To satisfy electricity demand, which is set to double to around 300 TwH by 2040, Sweden's right-of-center government announced June 20 that it would instead lean more heavily on nuclear energy and subsidize the construction of new nuclear plants — plants green-lit in 2016 but sidelined for fear they would be too expensive, reported Reuters. The country, home to just over 10.5 million people, presently has three nuclear plants with six nuclear reactors in commercial operation. The state-owned Vattenfall aims to bring the tally up to eight reactors and refurbish extant facilities. While Sweden's heightened nuclear focus is consistent with the country's commitment to shifting entirely off fossil fuels in a way that doesn't altogether cripple the nation, this bullishness on carbon-free nuclear power represents a significant about-face on atomic energy, which the country decided in a 1980 referendum to phase out. Swedish support for nuclear energy is presently at a record high of 56%, up from 42% in 2022, reported Bloomberg. The jump in support has been attributed in part to the energy crisis that overwhelmed Europe in concert with the invasion of Ukraine and the revelation that renewable energies are not tenable as alternatives. A 2021 study published in the journal Nature Communications indicated, "If future net-zero emissions energy systems rely heavily on solar and wind resources, spatial and temporal mismatches between resource availability and electricity demand may challenge system reliability." The researchers indicated that "the most reliable renewable electricity systems are wind-heavy and satisfy countries' electricity demand in 72-91% of hours ... Yet even in systems which meet >90% o demand, hundreds of hours of unmet demand may occur annually." These lost hours could prove too dear in a country where temperatures routinely drop below freezing several months out of every year. Even the former energy minister for the defeated leftist Social Democratic Party, was cognizant of the country's strained energy situation, warning last August of "strains on the power system this winter," both in terms of outages and high prices. The U.S. Department of Energy indicated that nuclear energy is the most reliable energy source on this side of the Atlantic Ocean. Each nuclear reactor typically produces the same amount of power as 431 utility-scale wind turbines or 3.1 million solar panels. According to the Swedish government, roughly 75% of its electricity comes from hydroelectric (43%) and nuclear (31%) power. 16% of the electricity comes from wind power. Approximately 9% comes from combined heat and power plants, largely powered by biofuels. Solar energy has yet to crack 1% of total supply. Finance Minister Elisabeth Svan-tesson of the Moderate Party said, "We need more electricity production, we need clean electricity and we need a stable energy system." Since wind and solar won't cut it, "This creates the conditions for nuclear power," said Svantesson.
This is Garrison Hardie with your CrossPolitic Daily News Brief for Tuesday, June 27th, 2023. Fight Laugh Feast Conference - Ark Encounter This year, our Fight Laugh Feast Conference is at the Ark Encounter in Kentucky on The Politics of Six Day Creation. The politics of six day creation is the difference between a fixed standard of justice and a careening standard of justice, the difference between the corrosive relativism that creates mobs and anarchy and the freedom of objectivity, truth, and due process. The politics of six day creation establishes the authority and sufficiency of God’s Word for all of life: from what is a man or a woman, when does human life begin, and how is human society best organized? Come hear Ken Ham, Pastor Doug Wilson, Dr. Ben Merkle, Dr. Gordon Wilson, me and more, and of course a live CrossPolitic show! Mark your calendars for October 11th-14th, as we fight, laugh, and feast, with beer & psalms, our amazing lineup of speakers, our Rowdy Christian Merch, and a Sabbath Feast to wrap up the occasion. Maybe an infant baptism while we’re at it! Visit fightlaughfeast.com for more information! https://justthenews.com/politics-policy/anniversary-roe-v-wade-being-overturned-gop-rep-promotes-bill-help-expectant On anniversary of Roe v. Wade being overturned, GOP Rep. promotes bill to help expectant mothers On the anniversary of Roe v. Wade being overturned, Minnesota Republican Congresswoman Michelle Fischbach promoted a proposed bill titled "The HOPE Act" that promotes helping expectant mothers. "It is crucial that women are supported when facing an unexpected pregnancy, which is why I have introduced The Health, Opportunity, Protecting Life, Education (HOPE) Act, which improves access to prenatal telehealth care, supports positive alternatives to abortion, and improves access to information for expectant mothers, providing tangible ways to help women feel confident during and beyond their pregnancy," Fischbach wrote in an opinion piece published by The Hill. On June 24, 2022, the Supreme Court of the United States ruled to overturn Roe v. Wade, ending the constitutional right to abortion and allowing individual states to decide for themselves on whether to restrict or allow abortions. The HOPE Act would provide funding for grants and other activities related to maternal care. It would also establish informed consent and parental notification requirements for abortion providers. "The HOPE Act creates a pilot grant program to provide support and equipment like blood pressure monitors, scales, and portable fetal heart rate monitors to community health providers," Fischbach wrote. "Increasing telehealth options gives expectant mothers the flexibility they need to receive the care they deserve." It would also prohibit any government funding going to Planned Parenthood. https://www.foxnews.com/media/bud-light-sponsors-toronto-pride-parade-naked-men-children Bud Light sponsors Toronto Pride parade attended by naked men, children Bud Light is serving as an official sponsor of the Toronto Pride parade, where video footage shows naked men standing around and riding bicycles in clear view of children attending the event. The footage, captured by Beth Baisch of the Post Millennial, shows dozens of attendees riding past a large cheering crowd. The fully naked bikers, some covered in paint or tattoos, wave back at the crowd. One naked man high-fives an onlooker while another peddles a recumbent bike with a gold blow-up swan adorned around his neck. A second video shows a group of naked men with hats standing in a circle amidst the crowd. Several children walk past the group of men with their families. Another clip shows a person wearing a giant penis costume that covers his entire head. The camera captures a young girl sitting in a stroller and staring toward the phallic-costumed individual. Other videos show a group of naked men playing and rinsing themselves off alongside a fountain surrounded by kids. Meanwhile, a stage, clearly adorned with Bud Light branding, featured scantily clad dancers wearing fishnets, nipple stickers and strange sock-like masks. The company's website notes that this year's sponsorship is representative of a longstanding partnership with the Pride event. "Bud Light Canada has been a proud partner of Pride Toronto for the last 10 years. This year, we're commemorating this milestone with Pride Toronto by featuring them on our can design, as well as continuing as the official beer sponsor of the festival," the beer brand's website states. According to the website, Bud Light Canada also provides $100,000 to various organizations that support the LGBTQUA2S+ community across Canada and has created a range of commemorative Pride beer cans to celebrate the collaboration. The partnership comes nearly three months after Bud Light received massive backlash for partnering with trans activist Dylan Mulvaney. The decision angered consumers and the brand saw a significant decrease in sales, resulting in billions of dollars in lost market value. In early April, Anheuser-Busch CEO Brendan Whitworth attempted to douse the flames with a lengthy statement to customers. "We never intended to be part of a discussion that divides people. We are in the business of bringing people together over a beer," he said in part. "My time serving this country taught me the importance of accountability and the values upon which America was founded: freedom, hard work and respect for one another. As CEO of Anheuser-Busch, I am focused on building and protecting our remarkable history and heritage." Despite losing business, Bud Light continued to anger customers for co-sponsoring an "all-ages Pride event" in Flagstaff, Arizona, on June 17. The party, called "Pride in the Pines," included drag queens and other performers, and listed Bud Light as one of the companies sponsoring the June 17 event. (Bud Light was initially mentioned prominently in one of the posters.) The event is listed as a "family festival event" and a family-friendly, "safe space" for all visitors. https://www.foxnews.com/us/colorado-springs-club-q-nonbinary-shooting-suspect-pleads-guilty-murder-charges Colorado Club Q 'nonbinary' shooter sentenced to life in prison after pleading guilty to murder Club Q shooting suspect Anderson Lee Aldrich was sentenced to life in prison after pleading guilty to murder and attempted murder charges during an arraignment hearing Monday morning, avoiding the prospect of a public trail just seven months after the deadly Colorado attack. Aldrich, who public defenders have said identifies as nonbinary and prefers to be described using they/them pronouns, is accused of fatally shooting five people and wounding 17 others at the LGBTQ+ nightclub Club Q in Colorado Springs, Colorado, on Nov. 19, 2022. The suspect, whom the judge referred to as "Mx. Aldrich" during Monday’s arraignment hearing, accepted a plea agreement for a life sentence without the possibility of parole in exchange for pleading guilty to five counts of first-degree murder. Aldrich also pleaded guilty Monday to 46 counts of attempted murder in the first degree. The suspect pleaded no contest to felony and misdemeanor charges of bias-motivated crimes. "Because of the evidence presented I believe there is a high probability of being convicted at trial to those counts, and so I am pleading no contest or nolo contendere," Aldrich told the court Monday, explaining the no contest plea. In an interview from jail, Aldrich reportedly admitted to The Associated Press to being on a "very large plethora of drugs" and abusing steroids at the time, expressing regret for the attack and adding that suggesting the shooting was motivated by hate was "completely off base." In court hearings earlier this year, law enforcement testified that Aldrich ran a neo-Nazi website and used gay and racial slurs while gaming online, while the defense countered that Aldrich's sometimes abusive mother forced the suspect to frequent LGBTQ+ clubs. Two veterans out at Club Q reportedly helped thwart the attack by disarming Aldrich, who was beaten by patrons and displayed a bruised and bloodied face in his initial mugshot and court appearance. Aldrich was facing more than 300 state counts, including murder and hate crimes. The Justice Department is also considering pursuing federal hate crime charges, according to a senior law enforcement official who spoke to the AP. However, the charges against Aldrich were thrown out in July 2022 after Aldrich's mother and grandparents, the victims in the case, refused to cooperate with prosecutors, evading efforts to serve them with subpoenas to testify, according to court documents unsealed after the shooting. Other relatives told a judge they feared Aldrich would hurt the grandparents if released, painting a picture of an isolated, violent person who did not have a job and was given $30,000 that was spent largely on the purchase of 3D printers to make guns, the records showed. Aldrich was released from jail then and authorities kept two guns -- a ghost gun pistol and an MM15 rifle – seized in the arrest. But there was nothing to stop Aldrich from legally purchasing more firearms, raising questions immediately after the shooting about whether authorities should have sought a red flag order to prevent such purchases. https://www.washingtonexaminer.com/news/nearly-half-bee-colonies-died-2023 Nearly half of honey bee colonies died in 2023 after three tumultuous years From April of last year to April of this year, 48% of honey bee colonies prematurely died off. University of Maryland and Auburn University have collaborated with nonprofit Bee Informed to track and report on managed bee colonies every year since 2007. Last year saw losses of 48%, the previous year’s loss was 39%, and the year before that, it was 50.8%. The average loss over the last 12 years is 39.6%. The cause of these losses is a mix of the parasitic mite, varroa destructor, which helps spread viruses between bees, increased use of pesticides, which inhibit the bee's ability to stave off diseases, and dramatic changes in the environment. When it becomes warmer than usual during the winter, bees will leave their colonies to begin pollinating many of the crops we eat, as well as other plants, but when the weather chills again, the bees die off. Still, the most commonly reported cause of death during the winter was the varroa. During the rest of the year, the most common report revolved around issues with the queen bee. "High levels of losses do not necessarily result in a decrease in the total number of colonies managed in the United States because beekeepers can replace lost colonies throughout the year," the report read. This report comes from a self-reported survey of 3,006 beekeepers from across the United States who collectively manage 314,360 colonies, the majority of which are commercially operated. This is only 12% of the estimated 2.70 million managed honey-producing colonies in the country in 2022, per the report. The collaboration, known as "the Bee Informed Partnership," is a non-profit organization dedicated to improving honey bee colony health in particular. https://www.conservativereview.com/unable-to-rely-on-wind-and-solar-sweden-ditches-100-renewable-target-and-bets-big-on-nuclear-power-2661896744.html Unable to rely on wind and solar, Sweden ditches 100% renewable target and bets big on nuclear power The Swedish parliament determined last week that in order to ensure the country has a "stable energy system," it will have to abandon its goal of "100 per cent renewable electricity production by 2040." To satisfy electricity demand, which is set to double to around 300 TwH by 2040, Sweden's right-of-center government announced June 20 that it would instead lean more heavily on nuclear energy and subsidize the construction of new nuclear plants — plants green-lit in 2016 but sidelined for fear they would be too expensive, reported Reuters. The country, home to just over 10.5 million people, presently has three nuclear plants with six nuclear reactors in commercial operation. The state-owned Vattenfall aims to bring the tally up to eight reactors and refurbish extant facilities. While Sweden's heightened nuclear focus is consistent with the country's commitment to shifting entirely off fossil fuels in a way that doesn't altogether cripple the nation, this bullishness on carbon-free nuclear power represents a significant about-face on atomic energy, which the country decided in a 1980 referendum to phase out. Swedish support for nuclear energy is presently at a record high of 56%, up from 42% in 2022, reported Bloomberg. The jump in support has been attributed in part to the energy crisis that overwhelmed Europe in concert with the invasion of Ukraine and the revelation that renewable energies are not tenable as alternatives. A 2021 study published in the journal Nature Communications indicated, "If future net-zero emissions energy systems rely heavily on solar and wind resources, spatial and temporal mismatches between resource availability and electricity demand may challenge system reliability." The researchers indicated that "the most reliable renewable electricity systems are wind-heavy and satisfy countries' electricity demand in 72-91% of hours ... Yet even in systems which meet >90% o demand, hundreds of hours of unmet demand may occur annually." These lost hours could prove too dear in a country where temperatures routinely drop below freezing several months out of every year. Even the former energy minister for the defeated leftist Social Democratic Party, was cognizant of the country's strained energy situation, warning last August of "strains on the power system this winter," both in terms of outages and high prices. The U.S. Department of Energy indicated that nuclear energy is the most reliable energy source on this side of the Atlantic Ocean. Each nuclear reactor typically produces the same amount of power as 431 utility-scale wind turbines or 3.1 million solar panels. According to the Swedish government, roughly 75% of its electricity comes from hydroelectric (43%) and nuclear (31%) power. 16% of the electricity comes from wind power. Approximately 9% comes from combined heat and power plants, largely powered by biofuels. Solar energy has yet to crack 1% of total supply. Finance Minister Elisabeth Svan-tesson of the Moderate Party said, "We need more electricity production, we need clean electricity and we need a stable energy system." Since wind and solar won't cut it, "This creates the conditions for nuclear power," said Svantesson.
17:48 - Congresswoman Michelle Fischbach - Representative of Minnesota's 7th Congressional District 1:20:51 - Matthew Schiltz - Attorney, Federal Trade Commission Midwest Region 1:44:03 - Brad Schipper - President of Virtual Health at Sanford Health What's on your mind? We want to know! Email us at StudioFlagFamily [dot] com Subscribe on Spotify, Apple, & Google
Chief Editor Barbara Cheifet speaks with Drs. Michael Fischbach and Sarkis Mazmanian about recent work uncovering functional roles for our microbiomes and what is needed to bring microbiome therapies to the clinic. Hosted on Acast. See acast.com/privacy for more information.
MICHELLE FISCHBACHSupport the show
This Episode we interview Jim Kielbaso, Dena Paulino, Joseph Fischbach about their take on being a Gym Owner. Welcome to the Gym Lords Podcast, where we talk with successful gym owners to hear what they're doing that is working RIGHT NOW, and to hear lessons and failures they've learned along the way. We would love to share your story! If you'd like to be featured on the podcast, fill out the form on the link below. https://gymlaunchsecrets.com/podcast
In this episode, Chris invites Jeffery Fischbach to the show to answer his famous 10 questions.
In this episode, Chris invites Jeffery Fischbach to the show to answer his famous 10 questions.
This Episode we interview Emily Throckmorton, Joe Fischbach, Anshuel Goel about their take on being a Gym Owner. Welcome to the Gym Lords Podcast, where we talk with successful gym owners to hear what they're doing that is working RIGHT NOW, and to hear lessons and failures they've learned along the way. We would love to share your story! If you'd like to be featured on the podcast, fill out the form on the link below. https://gymlaunchsecrets.com/podcast
All Gun Control laws are built upon lies. We will demonstrate and offer proof of the lies that are being told to justify the disarming of the American people. And no, a pistol brace is NOT a bump stock. During our Brownells Bullet Points we will consider the modern incarnation of the Armalite 180 and look at a couple of new products. For our Duracoat Finished Firearm segment we discuss color contrast between the gun and the sights. Also, for our SOTG Homeroom from CrossBreed Holsters we address the dangerous and potentially lethal mistake of substituting a less than lethal tool for a firearm when it comes to self-defense. Thanks for being a part of SOTG! We hope you find value in the message we share. If you've got any questions, here are some options to contact us: Send an Email Send a Text Call Us Enjoy the show! And remember…You're a Beginner Once, a Student For Life! TOPICS COVERED THIS EPISODE [0:04:50] DuraCoat Finished Firearms - DuraCoat University TOPIC: Contrasting Colors for Sight and Guns, www.studentofthegun.com/sights Huge thanks to our Partners:SDS Imports | Brownells | CrossBreed | Duracoat Firearm Finishes | Hi-Point Firearms [0:19:20] Brownells Bullet Points - Brownells.com TOPIC: BRN-180 in 7.62x39mm & Upgraded Side-Folding Stock Field Ops Trilogy from Nicholas Orr: https://amzn.to/3BxWpTm [0:28:30] SOTG Homeroom - CrossbreedHolsters.com TOPIC: Lethal Force vs. Less-than-Lethal [0:39:10] Gun Control is Built Upon Lies and They Know it. Will you be Ruled by Lies? 2016 Presidential Campaign: Searching for a Savior studentofthegun.com Dem Congressman Thinks a Stabilizing Brace Becomes a Bump Stock www.personaldefenseworld.com Joe Biden Says 9mm Bullet 'Blows The Lung Out of The Body' www.newsweek.com With assault rifles, exit wounds can be a foot wide. The victim's skull explodes on impact mobile.twitter.com [1:11:00] Medical Class: After-Action Report FEATURING: Personal Defense World, News Week, Madison Rising, Jarrad Markel, Paul Markel, SOTG University PARTNERS: SDS Imports, Brownells Inc, CrossBreed Holsters, DuraCoat Firearm Finishes, Hi-Point Firearms FIND US ON: Juxxi, Parler, MeWe.com, Gettr, iTunes, Stitcher, AppleTV, Roku, Amazon, GooglePlay, YouTube, Instagram, Facebook, Twitter, tumblr SOURCES From www.personaldefenseworld.com: Things heated up during a discussion surrounding a proposed amendment to the “assault weapon” ban. On the table is an amendment from Congresswoman Michelle Fischbach to add an exception for pistol stabilizing braces. At this point, Congressman Cicilline objected and pointed out the scary and dangerous details of a stabilizing brace. Only it didn't go quite how he planned. The amendment from Mrs. Fischbach, as read at the desk, states: “This act should not be interpreted to provide additional limitations on the import, sale, manufacture, transport, possession of a pistol with a stabilizing brace.” (Click Here for Full Article) From www.newsweek.com: President Joe Biden said a 9mm bullet "blows the lung out of the body" while discussing options on gun legislation on Monday, prompting some to suggest he was calling for handguns to be banned. Biden made the remarks while speaking to reporters outside the White House, a day after he and first lady Jill Biden visited Uvalde, Texas, and comforted families grieving the 19 children and two teachers who were killed in a mass shooting at an elementary school last week. (Click Here for Full Article)
Hour 3: Congresswoman Michelle Fischbach reacted to the overturning of Roe v. Wade; and Adam and Dan bid farewell to the show.
Scott Fischbach talks with Susie Jones about his views on abortion and Roe. v. Wade.
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