Podcasts about EF

EF-5 // Jonathan Owens // CDA Campus by Heart Of The City Church

In the aftermath of the devastating EF-4 tornado that recently swept through Kentucky, Mosheh visits the hardest-hit areas to document the extensive damage and speak directly with residents impacted by the storms. In this special two-part edition of the Mo News podcast, Part 1 features firsthand accounts from London, Kentucky, where 19 people were killed and hundreds of homes and businesses were destroyed. Survivors share their harrowing experiences, losses, and how their community is rallying together in the aftermath. Part 2 provides a behind-the-scenes look at disaster relief operations through the Acts of Good and Tide Loads of Hope programs based in Cincinnati. Filmed shortly before the Kentucky visit, this segment offered crucial context and insight into the outreach and recovery efforts observed on the ground in Kentucky. Mosh highlights the practical aid being provided to victims, including laundry services, showers, hygiene kits, and cleaning supplies delivered through P&G's Tide Loads of Hope mobile laundry unit. This episode is sponsored by Procter & Gamble and was produced in partnership with Matthew 25 Ministries and the Tide Loads of Hope program. -- Mosheh Oinounou (@mosheh) is an Emmy and Murrow award-winning journalist. He has 20 years of experience at networks including Fox News, Bloomberg Television and CBS News, where he was the executive producer of the CBS Evening News and launched the network's 24 hour news channel. He founded the @mosheh Instagram news account in 2020 and the Mo News podcast and newsletter in 2022.

David and Rachel discuss the devastation to Jarrell, Texas, caused by an EF-5 tornado in 1997. Script by Al Mason.

The May 16 EF-3 tornado destroyed Centennial Christian Church in the Fountain Park neighborhood in north St. Louis. One person died and two others were trapped beneath the rubble before they were rescued. In this episode, STLPR afternoon newscaster Marissanne Lewis-Thompson talks about their story. She also details how the people trapped below weren't able to successfully reach 911 during the disaster.

Centennial Christian Church sits in the heart of Fountain Park. It's the lifeline of the north St. Louis neighborhood. But last month, an EF-3 tornado destroyed the 121-year-old church. Three people were trapped inside buried beneath the rubble for nearly two hours. One of them did not make it out alive. Repeated calls from a victim inside Centennial to the city's 911 emergency line went unanswered.

A daily update on what's happening in the Rocket Pool community on Discord, Twitter, Reddit, and the DAO forum. #RocketPool #rpl #Ethereum #eth #crypto #cryptocurrency #staking #news Podcast RSS: https://anchor.fm/s/cd29a3d8/podcast/rss Anchor.fm: https://anchor.fm/rocket-fuel Spotify: https://open.spotify.com/show/0Mvta9d2MsKq2u62w8RSoo Apple Podcasts: https://podcasts.apple.com/us/podcast/rocket-fuel/id1655014529 0:00 - Welcome 0:44 - Rocket Pool newsSEC on staking https://www.sec.gov/newsroom/speeches-statements/statement-certain-protocol-staking-activities-052925 https://x.com/drjasper_eth/status/1928462829306196474 https://x.com/drjasper_eth/status/1928466266735435780 New Smart Node https://discordapp.com/channels/405159462932971535/918351974406172723/1377299061341687888 https://discordapp.com/channels/405159462932971535/468923220607762485/1377302081651740753 https://discord.com/channels/405159462932971535/1377299563483893790 https://discord.com/channels/405159462932971535/918351974406172723/1378069669805817936 Ronin use rETH https://x.com/Ronin_Network/status/1925921718905807029 https://x.com/chainlink/status/1926005300806468086 Big deposits clear the queue https://discord.com/channels/405159462932971535/894377118828486666/1372913174847819807 https://discord.com/channels/405159462932971535/894377118828486666/1375623907419099221 https://discord.com/channels/405159462932971535/894377118828486666/1375628495069380669 https://dune.com/rp_community/saturnqueues Forced exits for liquidity https://dao.rocketpool.net/t/rpip-71-reth-withdrawal-liquidity-via-eip-7002-i-e-forced-exits rETH in DeFi https://aerodrome.finance/liquidity?query=reth https://x.com/StakeRocketPool/status/1925932568005808151 https://x.com/Contango_xyz/status/1930282159803117622 Treasury report https://dao.rocketpool.net/t/pdao-2025-05-08-2025-06-05-treasury-report/3641 GMC R24 results https://dao.rocketpool.net/t/round-24-apr-7-may-7-grants-bounties-retrospective-awards-results/3632 Halooo saves node operator https://discord.com/channels/405159462932971535/468923220607762485/1374361271700291606 https://discord.com/channels/405159462932971535/468923220607762485/1380257699828334728 A thread for RPL holders https://discord.com/channels/405159462932971535/1376176509101932554/1376178088374702090 19:58 - Staking news Client releases https://github.com/NethermindEth/nethermind/releases/tag/1.32.0-rc NodeSet thriving Staking Nerd Talk https://www.youtube.com/watch?v=-LgLU8XZOmo 25:56 - Ethereum news EF protocol https://x.com/timbeiko/status/1929620145984753843 Joe Lubin's massive move https://x.com/ethereumJoseph/status/1927835694149554430 https://x.com/sassal0x/status/1927341934290337831 Etherealize doing amazing stuff https://x.com/etherealize_io/status/1928105280656576710?s=46&t=fw7aoxDh361C5QFfbMUkZw https://x.com/ryanberckmans/status/1928616332402008513 Gas to 60m! https://ethereum-magicians.org/t/all-core-devs-testing-acdt-39-june-2-2025/24376/2 ETH ETFs coming to life https://x.com/vivekventures/status/1927939812524228648 Slot time discussion https://x.com/dankrad/status/1925282551280599221 TradFi on Ethereum https://www.coindesk.com/markets/2025/05/20/socgen-s-crypto-arm-to-launch-dollar-denominated-stablecoin-on-ethereum-reports-say Liquity V2 live https://x.com/liquityprotocol/status/1924465010925056106 https://x.com/Rocket_Pool/status/1930691077645779006 39:54 - In other news BTC ATH - others lagging https://www.thestreet.com/crypto/markets/bitcoin-hits-new-all-time-high GENIUS ACT likely to pass https://x.com/jchervinsky/status/1924642228070182969 6000 songs https://x.com/songadaymann/status/1930642287085674901 Raffle for May https://discord.com/channels/405159462932971535/1008896635734069349/1381175733719928882 https://harpocryptes.github.io/raffle.html

Nesse episódio trouxemos as notícias e novidades do mundo da programação que nos chamaram atenção dos dias 31/05 a 06/06.

Nesse episódio trouxemos as notícias e novidades do mundo da programação que nos chamaram atenção dos dias 31/05 a 06/06.

Welcome to The Chopping Block – where crypto insiders Haseeb Qureshi, Tom Schmidt, Tarun Chitra, and Robert Leshner chop it up about the latest in crypto. In this episode, the crew tackles a triple-header of crypto's growing pains: the bizarre saga of James Wynn—a memecoin gambler whose billion-dollar positions on Hyperliquid ended in public ruin; the Ethereum Foundation's surprise rebrand into “Protocol” and its sudden embrace of hierarchy; and a bold manifesto from Miles Jennings calling for the end of crypto foundations as we know them. Is radical transparency a feature or a trap? Is Ethereum finally prioritizing execution over vibes? And are foundations just offshore theater—or necessary guardians of decentralization? The gang debates all this and more in a conversation that asks: who's really in control of crypto—and should they be? Show highlights

Neste episódio, o Pastor @Juanribe Pagliarin traz uma mensagem impactante sobre a grande transformação que Deus realiza na vida de quem decide deixar a velha natureza para trás. Com base em Efésios 4:22, você vai entender o que significa despir-se do velho homem e ser renovado no espírito, vestindo-se da nova criatura em Cristo. Este é um chamado à verdadeira mudança, não de aparência, mas de essência.

Welcome to The Chopping Block – where crypto insiders Haseeb Qureshi, Tom Schmidt, Tarun Chitra, and Robert Leshner chop it up about the latest in crypto. In this episode, the crew tackles a triple-header of crypto's growing pains: the bizarre saga of James Wynn—a memecoin gambler whose billion-dollar positions on Hyperliquid ended in public ruin; the Ethereum Foundation's surprise rebrand into “Protocol” and its sudden embrace of hierarchy; and a bold manifesto from Miles Jennings calling for the end of crypto foundations as we know them. Is radical transparency a feature or a trap? Is Ethereum finally prioritizing execution over vibes? And are foundations just offshore theater—or necessary guardians of decentralization? The gang debates all this and more in a conversation that asks: who's really in control of crypto—and should they be? Show highlights

Okay, so this week we're talking about one of the most powerful tools we have out there for our focus, our mental health, our community, our families, our children, ourselves - music! We don't even realize how much music plays a role in our lives. And luckily, gone are the days of believing we must work in sterile, silent environments - many (or dare I say most?) brains, including those with ADHD and other EF challenges, truly benefit from some kind of stimulation while doing focused work. The power of music has been studied by researchers so if you'd like to learn more, I've shared some articles in the show notes. But one of the best resources I can recommend is a new book out called Resonant Minds. Written by a daughter and father pair, Sara and Mort Sherman, this book covers all aspects of music - from its impact on the brain and learning, including as a mindfulness practice or as Sara and Mort call it “mindful action”, to its positive impact on individuals and community. I sat down with Sara and Mort to learn about music and share stories about how music has impacted us and others and about, as Sara and Mort say, that music is ultimately about love. Sara and Mort are so uniquely qualified to write this book so I asked them to introduce themselves, and the book Resonant Minds is such a unique book that I knew it was only right for them to describe it, so let's get on with the show!Here are the show notes from today's episode:Learn More About Sara Shermanhttps://mozartformunchkins.com/Learn More About Morthttps://my.aasa.org/AASA/Resources/SAMag/Sep16/InsideSherman.aspxResonant Minds bookhttps://mozartformunchkins.com/resonant-minds-the-transformative-power-of-music-one-note-at-a-time/https://www.resonantminds.comResearch on Music and the BrainMelody for the Mind: Enhancing Mood, Motivation, Concentration, and Learning through Music Listening in the Classroomhttps://journals.sagepub.com/doi/full/10.1177/20592043231214085Keep Your Brain Young with Musichttps://www.hopkinsmedicine.org/health/wellness-and-prevention/keep-your-brain-young-with-musicThe transformative power of music: Insights into neuroplasticity, health, and diseasehttps://pmc.ncbi.nlm.nih.gov/articles/PMC10765015/The Youth Orchestra Hannah mentioned: https://gctyo.org/Learn More About Our MAP Programhttps://map.worksmartcoaching.comLearn More About 1:1 Coachinghttps://www.beyondbooksmart.com/how-it-worksGet in Touchpodcast@beyondbooksmart.comInstagram/Facebook/Tiktok: @beyondbooksmartcoachingwww.beyondbooksmart.com

Hva skjer når vi lever med en bevissthet om at Gud allerede er her – midt i hverdagen? Et enkelt, radikalt liv kan vitne høyere enn ord og vekke spørsmål som peker mot håpet vi bærer.Bibelreferanser: 1. pet 3:13-17, Salme 139:5-8, Ef 2:10, Apgj 1:8,

Kencan Dengan Tuhan - Senin, 2 Juni 2025Bacaan: "Karena kuasa ilahi-Nya telah menganugerahkan kepada kita segala sesuatu yang berguna untuk hidup yang saleh oleh pengenalan kita akan Dia, yang telah memanggil kita oleh kuasa-Nya yang mulia dan ajaib. Dengan jalan itu Ia telah menganugerahkan kepada kita janji-janji yang berharga dan yang sangat besar, supaya olehnya kamu boleh mengambil bagian dalam kodrat ilahi, dan luput dari hawa nafsu duniawi yang membinasakan dunia." (2 Petrus 1:3-4) Renungan: Suatu ketika di sebuah acara pertemuan ada seorang pria berdiri untuk memberikan sebuah kesaksian. "Aku pernah tinggal di Pennsylvania sebagai seorang gelandangan selama beberapa tahun. Pekerjaanku hanyalah mengemis di jalanan agar dapat bertahan hidup. Suatu hari, aku menyentuh bahu seorang laki-laki sambil berkata, 'Tuan, tolong beri aku sedikit uang.' Segera laki-laki itu membalikkan wajahnya ke arahku dan betapa kagetnya aku karena wajah itu sangat kukenal: ternyata ia adalah ayahku. 'Ayah, apakah engkau tidak mengenalku?' kataku. Segera kedua tangannya memelukku dan sambil menangis ia berkata, 'Aku sudah menemukanmu, dan kau perlu tahu bahwa semua yang aku miliki adalah milikmu.'" Seperti inilah Bapa di Sorga mencari anak-anak-Nya yang terhilang. la mencari dengan penuh kerinduan bukan agar sekadar kita kembali kepada-Nya, melainkan la mencari kita agar kita kembali kepada-Nya dan menerima kekayaan yang disediakan-Nya melalui Kristus Yesus. "Supaya pada masa yang akan datang la menunjukkan kepada kita kekayaan kasih karuniaNya yang melimpah-limpah sesuai dengan kebaikan-Nya terhadap kita dalam Kristus Yesus. "(Ef 2:7). Kekayaan kasih karuniaNya yang dimaksudkan bukan hanya karyaNya yang mendatangkan keselamatan bagi jiwa kita, tetapi juga untuk menerima berkat-berkat yang sudah la janjikan. Dan kelak, kita akan menerima kemuliaan yang akan dianugerahkan kepada kita bersama dengan Kristus. Jika kita tahu bahwa Allah menyediakan semua yang baik bagi kita, mengapa kita masih tinggal dalam kehidupan yang terpisah jauh dari Allah? Sudah cukup banyak waktu yang kita pakai untuk melakukan yang sia-sia, sekarang saatnya untuk kembali kepada Allah. Kesenangan dunia ini hanya sementara, tetapi apa yang Allah sediakan kekal adanya. Tuhan Yesus memberkati. Doa:Tuhan Yesus, terimalah aku yang berdosa ini. Sudah cukup lama aku hidup terpisah jauh dari-Mu, aku rindu menikmati kelimpahan kasih-Mu. Amin. (Dod).

Tekst kazalny: Ef 3, 14-21 Prowadzenie: ks. Małgorzata Gaś

Ayer avanzamos parte del concierto que el pasado 4 de mayo, que además era el día de la madre, ofrecieron Los Hermanos Cubero en la quinta edición de La Veguilla Folk Festival, celebrada en las Bodegas La Cepa Alta de Olivares de Duero (Valladolid). El concierto en total duró más de hora y cuarenta minutos, por eso lo hemos tenido que dividir en dos partes y aun así hemos quitado algunas canciones, no sin cierta tristeza. Lo bueno del concierto de Quique y Roberto ese día es que no se centró solo en su reciente disco “Cubero bueno, Cubero malo” sino que también interpretaron piezas de otros discos anteriores, incluso de sus dos EPs que se editaron exclusivamente en formato vinilo pequeño.Compruébalo en este repertorio escogido, continuación a lo ofrecido ayer en La Tarataña y grabado en vivo en La Veguilla:1.- Los Hermanos Cubero, “Seguidillas de Mondéjar” 3:28, “G.U.A.D.A.L.A.J.A.R.A.” 3:00, “Muy tonto para Madrid, muy feo para Barcelona” 2:47, “Pasacalles de procesión” 2:30, “Como si alcanzar pudiera” 3:37 “Efímera” (con Abril Ruíz) 2:40, “Canción para un final, canción para un principio” (con Abril Ruíz) 3:03, “Llama encendida” 3:30, “En el baile” 3:10, “Cuberología” 2:31, “Cubero bueno, Cubero malo” 2:23, “El aire” 3:05, “La molinera y el corregidor” 4:02, “Maldita urraca” 2:58 y “La calle abajo” 2:38Escuchar audio

Votre séance d'endurance fondamentale est-elle foutue si vous sortez parfois de la zone ? Cette question m'a été posée par Clément qui s'inquiète des conséquences d'une dérive cardiaque sur quelques secondes pendant ses sorties en EF. Je vais vous expliquer pourquoi c'est normal et surtout pourquoi il ne faut pas trop vous focaliser dessus.La dérive cardiaque se traduit par une augmentation progressive de la fréquence cardiaque, même si l'allure reste stable. De nombreux coureurs et coureuses ont du mal à rester dans la zone de l'endurance fondamentale pendant leur sorties running.Ainsi Clément se demande si « ça ‘tue' une EF d'avoir une dérive cardiaque sur quelques sec ? (Côte, mini accélération..) »Dans cet épisode :c'est quoi la dérive cardiaquequels sont les éléments qui amènent un dérive cardiaque (fatigue, chaleur, stress, déshydratation…)quand est-elle normale ?quand est-elle anormale ?pourquoi vous n'y feriez pas attention sans votre montre❤️ Me suivre Tous les liens sont ici

Primeira Leitura: At 1,1-11 | Salmo: Sl 46,2-3.6-7.8-9 (R.6) | Ef 1,17-23 | Evangelho: Lc 24,46-53Compartilhe com amigos e familiares. Baixe nosso APP com conteúdos católicos: orações, reflexões, homilias e muito mais.Conheça nosso canal youtube/voxcatolicawww.voxcatolica.com.brNarração: Sonia Abreu

Præludium: Johannes Barend Litzau: Til Himmels fór den ærens drot Fra det G.T.: Salme 113 Salme: 254 "Fuldendt er nådens store værk" Fra det N.T.: Lukasevangeliet 24,44-53 Vekselsang: Kristus opfór til det høje (Ef. 4, 8.10) Salme: 264 "Herre Jesus, du, som troner" Postludium: Jesper Madsen: Til Himmels fór den ærens drot

Palavra de Deus, você enfrenta e vence a luta e a lida do dia a dia.Neste episódio: Efésios 1,17-23

Aprofunde sua devoção a Deus em fiel.in/devocionalAlgo para se gloriarPorque pela graça sois salvos, mediante a fé. (Efésios 2.8)O Novo Testamento correlaciona fé e graça para assegurar que não nos gloriemos no que a graça realiza sozinha.Um dos exemplos mais familiares é esse: “Porque pela graça sois salvos, mediante a fé” (Efésios 2.8). Pela graça, mediante a fé. Aqui está a correlação que protege a gratuidade da graça.A fé é o ato de nossa alma de se voltar da nossa própria insuficiência para os livres e suficientes recursos de Deus. A fé focaliza-se na liberdade de Deus para conceder graça aos indignos. Ela se baseia na liberalidade de Deus.Então, a fé, por sua própria natureza, anula a vanglória e se adequa à graça. Seja para onde for que a fé olhe, ela vê a graça por trás de cada ato digno de louvor. Portanto, ela não pode se gloriar, senão no Senhor.Assim, Paulo, depois de dizer que a salvação é pela graça, mediante a fé, diz: “e isto não vem de vós; é dom de Deus; não de obras, para que ninguém se glorie” (Efésios 2.8-9). A fé não pode se gloriar da bondade, nem da competência, nem da sabedoria humana, porque a fé se concentra na livre graça de Deus, que tudo suporta. Seja qual for a bondade que a fé veja, ela a vê como o fruto da graça.Quando a fé olha para nossa “sabedoria, e justiça, e santificação, e redenção”, ela diz: “Aquele que se gloria, glorie-se no Senhor” (1 Coríntios 1.30-31).--Devocional Alegria Inabalável, por John Piper | Editora Fiel.Conteúdo oferecido em parceria entre Desiring God e Ministério Fiel.

Ethereum researchers proposed forced inclusion lists for Glamsterdam. Over 150,000 validators signal a 60m gas limit. Rocket Pool integrates Chainlink CCIP. And the EF is looking to hire a talent partner. Read more: https://ethdaily.io/709 Disclaimer: Content is for informational purposes only, not endorsement or investment advice. The accuracy of information is not guaranteed.

Præludium: Francisco Luna: Til Himmels fór den ærens drot Fra det G.T.: 1. Mosebog 1,1-8 Salme: 257, vers 1 + 4-5 "Vaj nu, Dannebrog, på voven" Fra det N.T.: Apostlenes Gerninger 1,6-12 Vekselsang: Kristus opfór til det høje (Ef. 4, 8.10) Salme: 251 "Jesus, himmelfaren" Postludium: Healey Willan: Ascension

«En el caso costarricense, la posibilidad de “piropear”... constituye... un elemento revelador del quehacer popular y de la idiosincrasia del pueblo. Ahora bien, el piropo ha sufrido un desgaste en su uso. En sus inicios... los emisores [y] los receptores [se conocían].... [Pero] al [dejar de conocerse] la mayoría... el piropo pasaría al anonimato, y sus enunciados originarios de galantería positiva se convertirían en contenidos distintos, conducentes más bien a la degradación... [con] rasgos como el ingenio, la picardía, la sátira... el... chiste... y el vacilón como categorías... en el enfrentamiento diario a muchas situaciones.... »El piropo es, en principio, un mensaje lingüístico que tiene como finalidad esencial despertar una reacción concreta en el destinatario. La respuesta puede ser negativa o positiva, de acuerdo con la intencionalidad del emisor del discurso.... »En buena parte de los casos, el hombre abre el proceso; pero en muchas situaciones la mujer, o inicia el mensaje o responde coherentemente a lo planteado por el hombre: »—¡Adiós, Ricura! »—¿Qué le pasa, mechudo? »Esa ingeniosa respuesta se la dio una decidida muchacha a un sujeto que no tenía un solo cabello en la cabeza.... »... Emilia Prieto se interesó en recuperar [los siguientes] piropos de corte tradicional, [algunos en verso]: »“Si así son las flores, mi profesión es jardinero.” »“Como la luna en el cielo o la rosa en el vergel tenés el candor de un lirio y la gracia de un clavel.” »“La sonrisa de tus labios tiene dulzura infinita, y cuando veo tu sonrisa toda pena se me quita.” »“Sentí tu presencia un día al llegar a este lugar. Muñeca, ¡qué lindo sería que formáramos un hogar!” »... [He aquí otros piropos] del hombre a la mujer: »—¡Amor, eres un castigo para cualquier hombre!... »—Adiós, linda. ¡Con esos ojos iluminas mi vida!... »—¡Juguemos ajedrez: usted la dama, yo el rey!... »—Suegra, vaya con Dios, que yo voy con su hija.... »—No le pida más a Dios, porque ya se lo dio todo.... »—Si la belleza fuera pecado, usted no tendría perdón de Dios....1 Así trata el profesor costarricense Guillermo Barzuna el tema del piropo en su obra titulada Caserón de teja: Ensayos sobre patrimonio y cultura popular en Costa Rica. ¡Qué interesante es observar cómo la cultura religiosa está tan arraigada en la cultura popular que hasta da como resultado piropos que aluden a Dios! Pero ¿será una teología sana la que resulta de todo eso? Menos mal que, si bien no se crearon con ese fin, algunos piropos sí se prestan para la reflexión espiritual. Por ejemplo, ¿es posible recibir tanta bendición de Dios, ya sea física, material o espiritual, que no haga falta pedirle más? Tal vez... El salmista David presenta a Dios como quien colma de bienes nuestra vida, y nos rejuvenece como a las águilas,2 y San Pablo lo describe como quien «puede hacer muchísimo más que todo lo que podamos imaginarnos o pedir».3 Pero, en definitiva, ¡Dios sí nos concedería el perdón, con tal que se lo pidiéramos, si la belleza con que nos haya creado fuera tan deslumbrante que se juzgara pecado! Carlos ReyUn Mensaje a la Concienciawww.conciencia.net 1 Guillermo Barzuna, «Tradición, seducción y decadencia en el piropo costarricense», Caserón de teja: Ensayos sobre patrimonio y cultura popular en Costa Rica (San José, Costa Rica: Editorial Nueva Década, 1989), pp. 40‑48. 2 Sal 103:5 3 Ef 3:20

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En este mensaje tratamos el caso de un hombre que «descargó su conciencia» de manera anónima en nuestro sitio www.conciencia.net y nos autorizó a que lo citáramos, como sigue: «Esperé hasta los cuarenta años para casarme, pero estoy casi seguro de que me equivoqué.... Estos casi seis años de casado han sido tormentosos.... Los dos nos hemos maltratado verbalmente.... No me puedo poner de acuerdo en nada con ella porque siempre se forma una discusión.» Este es el consejo que le dio mi esposa: «Estimado amigo: »Hasta cumplir los cuarenta años usted sin duda estaba bien ajustado a su vida de soltero, habiéndose acostumbrado a la libertad de no tener que consultar a nadie más en su toma de decisiones. Así que no debiera sorprenderlo que haya sido un gran ajuste el tener que hacer tantos cambios en su vida diaria para adaptarse a una esposa, después de muchos años de haber hecho todo por sí solo. Es normal que se le esté haciendo difícil realizar esos cambios.... »Usted dice que cree que se equivocó. Estamos de acuerdo. Fue un error pensar que pudiera incorporar a una esposa en su vida sin reconocer todas las maneras en que necesitaría cambiar y toda la independencia a la que tendría que renunciar. Sin embargo, sospechamos que usted tendría muchas de las mismas dificultades si se hubiera casado con otra mujer....   »En vez de enfocarse en su infelicidad, le recomendamos que se concentre en salvar su matrimonio. El primer paso es hacer todos los sacrificios necesarios para comenzar a valerse de consejería profesional. Ustedes dos necesitan recibir instrucción y práctica sobre cómo comunicar de una manera positiva lo que quieren y lo que necesitan.... »No estamos culpándolo por todos los problemas en su matrimonio, pero usted es el que nos está pidiendo ayuda. Es importante dejar de enfocarse en quién tiene la culpa y pensar más bien en cómo puede usted mejorar su futuro. Al margen de cómo responde su esposa, usted puede seguir la enseñanza del apóstol Pablo de que el hombre debe amar a la esposa de la misma manera en que Jesucristo ama a la iglesia.1 »¿Qué hizo Cristo a favor de la iglesia? Él sacrificó su vida y murió voluntariamente en una cruz para perdonar el pecado. »A veces parece más fácil morir por una persona que vivir por ella. Es porque se muere una sola vez, y luego todo termina. En cambio, se vive cada día, todo el día, día tras día tras día... »Piense en tres cosas que usted puede hacer por su esposa hoy que demostrarán que la ama. No pregunte lo que ella va a hacer por usted, y no mantenga el puntaje de lo hecho. Simplemente muéstrele hoy su amor, sin que importe cómo ella responda. Luego añada otras tres cosas mañana, y así sucesivamente. Pídale a Dios que le muestre cómo de veras amarla y valorarla sin esperar en absoluto que ella vaya a corresponder.» Con eso termina lo que Linda, mi esposa, recomienda en este caso. El caso completo puede leerse con sólo pulsar la pestaña en www.conciencia.net que dice: «Casos», y luego buscar el Caso 724. Carlos ReyUn Mensaje a la Concienciawww.conciencia.net 1 Ef 5:25

Lancet 1999;353:2001-07Background: Beta-blockers directly reduce cardiac contractility and myocardial oxygen demand. For decades, they were avoided in patients with acute and chronic heart failure over concerns they would facilitate decompensation of the condition. The therapeutic cornerstones of treatment, prior to the modern era of clinical trials, focused on managing symptoms and quality of life with diuretics and inotropic agents like digoxin; however, new paradigms were arising that focused on addressing neurohormonal mechanisms of chronic disease that were over-activated in the failing heart. The first major success came with inhibition of the renin angiotensin aldosterone system with angiotensin converting enzyme inhibitors whose effect on mortality for patients with mild and severe forms of chronic heart failure were demonstrated in the V-HEFT II, CONSENSUS, and SOLVD trials. Additional benefits were demonstrated with the mineralocorticoid receptor antagonist spironolactone in the RALES trial. These drug classes primarily work by reducing afterload and volume retention. Appreciating why they work for improving cardiac performance and managing symptoms in heart failure patients is straightforward when we consider the major factors that effect cardiac stroke volume - preload, afterload and contractility; however, it is also noteworthy the effects these agents have on sudden death. How beta-blockade benefits the failing heart is less obvious (outside prevention of sudden death). Mechanistic studies in patients with chronic heart failure have consistently shown that when beta blockers are used for more than 1 month, left ventricular function improves. Beta blocker therapy appears to restore the density of beta-adrenergic receptors after they have been downregulated by the chronic overactivity of the sympathetic nervous system. The first major placebo-controlled RCT to demonstrate a mortality benefit used the non-selective beta blocker carvedilol. The trial was small and not originally designed to test mortality and was stopped early without clearly predefined stopping rules. Furthermore, 8% of total patients selected for participation in the trial were excluded prior to randomization after a 2 week, open-label run-in phase with the study drug, which saw 2% of all patients experience worsening heart failure or death representing 24 patients (the difference in total deaths between groups was 9 when the trial was stopped). The Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF) was the first large scale trial designed to test the hypothesis that beta-blockade with metoprolol controlled/extended release (CR/XL) added to optimum medical therapy reduces mortality in patients with chronic systolic heart failure.Patients: Patients were recruited from 313 sites in 13 European countries and the United States. Eligible patients were men and women between the age of 40 to 80 years with symptomatic heart failure (NYHA class II-IV) for >/= 3 months before randomization. They had to be on a diuretic and ACE inhibitor for at least 2 weeks. Other drugs, including digoxin, could also be used. Patients also had to have an EF of /=68 beats per minute.Patients were excluded if: they had an MI or unstable angina within 28 days; had an indication or contraindication for treatment with beta-blocker; beta blockade within 6 weeks; heart failure due to systemic disease (i.e., amyloidosis) or alcohol abuse; scheduled or performed cardiac transplant; an ICD; procedures such as CABG or PCI planned or performed in the past 4 months; 2nd or 3rd degree AV block unless a pacemaker was present; unstable or decompensated heart failure defined by pulmonary edema or hypoperfusion or supine systolic BP 25% deviation of the number of observed versus expected consumed placebo tablets during the run-in period.Baseline characteristics: The mean age of patients was 64 years and approximately 78% were male. Slightly more than 30% of patients were above the age of 70. The average EF was 28%. The average SBP was 130 mmHg and heart rate was 82 bpm. Most patients had mild to moderate heart failure, with 41% in NYHA Class II, 56% in Class III, and only 3% in Class IV. Ischemic cardiomyopathy accounted for 65% of cases and nonischemic causes accounted for 35%. Most patients were on an ACE inhibitor or ARB (95%) and diuretic (90%). Digoxin was used in 63%. Trial procedures: Prior to randomization, the study was preceded by a single-blind, 2-week placebo run-in period. Patients meeting eligibility were then randomized to placebo or metoprolol CR/XL. The starting dose of placebo or metoprolol CR/XL was 12.5 mg daily for patients in NYHA class III or IV and 25 mg daily for patients in NYHA class II. The dose was doubled every 2 weeks until the target dose of 200 mg daily was reached. Patients were followed every 3 months.Endpoints: The primary outcome was all-cause mortality. It was estimated that 3,200 patients would need to be followed for 2.4 years to detect a 30% relative reduction in mortality based on annual mortality rate of 9.4% in the placebo group. This would achieve at least 80% power with a 2-sided alpha of 0.04. Patients were recruited faster then planned and so the final sample size of 3,991 patients increased the power of the study.The study was monitored by an independent safety committee and predefined stopping rules for efficacy were based on all-cause mortality, done when 25%, 50%, and 75% of expected deaths had occurred. Results: The trial was stopped early after the 2nd preplanned interim analysis when 50% of expected deaths had occurred. The mean duration of follow-up at the time of stopping was 1 year. The mean daily dose of metoprolol CR/XL was 159 mg once daily, with 87% receiving 100 mg or more and 64% receiving the target dose of 200 mg daily. In the placebo group, the corresponding values were 179 mg daily, 91% and 82%. The study drug was discontinued permanently in 14% of patients in the metoprolol group and 15% in the placebo group. Six months after randomization, heart rate decreased by 14 bpm in the metoprolol group compared to only 3 bpm in the placebo group. Systolic blood pressure decreased less in the metoprolol group (-2.1 vs 3.5 mmHg).Compared to placebo, metoprolol significantly reduced all-cause mortality (7.3% vs 10.8%; RR 0.66; 95% CI 0.53—0.81). Cardiovascular mortality accounted for 91% of all deaths; with sudden death accounting for 58% and death from worsening heart failure accounting for 24% of all deaths. All 3 of these causes of death were significantly reduced by metoprolol. The relative and absolute effects on death were greatest for patients with NYHA class III heart failure.Conclusions: In this trial of stable patients with mild to moderate chronic systolic heart failure, who were optimized on an ACEi or ARB and diuretic, metoprolol CR/XL significantly reduced all-cause mortality. Approximately 30 patients would need to be treated with metoprolol compared to placebo for 1 year to prevent 1 death. This trial represents a significant win for beta blockade in patients with chronic systolic heart failure. While the NNT in this trial is slightly higher than in SOLVD, it is important to appreciate that follow-up time in SOLVD was more than 3x longer. Limitations to external validity in this trial include the run-in period and stringent inclusion and exclusion criteria. Our enthusiasm is also tempered by early stopping, which has been found to be associated with false positive or exaggerated results but this concern is mitigated to some extent in this trial because the rules for early stopping were clearly defined in the protocol.Cardiology Trial's Substack is a reader-supported publication. To receive new posts and support our work, consider becoming a free or paid subscriber. Get full access to Cardiology Trial's Substack at cardiologytrials.substack.com/subscribe

This week, Meteorologist Jake Grant and Meteorologist Erich Ahlf are back to recap the severe weather event that occurred this past Friday, which notably produced an EF-1 tornado. They discuss the setup and track of the tornado that tracked across parts of Dorchester and Sussex counties.

¿Sientes que lo único que hace es simplemente respirar y trabajar? Bueno el PLAN de Dios es tomar GENTE ordinaria y ponerla en lugares ordinarios con trabajos ordinarios y obtener gloria extraordinaria para Sí mismo. ¡Eso sí que es un trabajo importante!Ef. 6:5 To support this ministry financially, visit: https://www.oneplace.com/donate/276/29

¿Sientes que lo único que hace es simplemente respirar y trabajar? Bueno el PLAN de Dios es tomar GENTE ordinaria y ponerla en lugares ordinarios con trabajos ordinarios y obtener gloria extraordinaria para Sí mismo. ¡Eso sí que es un trabajo importante!Ef. 6:5 To support this ministry financially, visit: https://www.elsitiocristiano.com/donate/276/29

¿Sientes que lo único que hace es simplemente respirar y trabajar? Bueno el PLAN de Dios es tomar GENTE ordinaria y ponerla en lugares ordinarios con trabajos ordinarios y obtener gloria extraordinaria para Sí mismo. ¡Eso sí que es un trabajo importante!Ef. 6:5 To support this ministry financially, visit: https://www.oneplace.com/donate/276/29

¿Sientes que lo único que hace es simplemente respirar y trabajar? Bueno el PLAN de Dios es tomar GENTE ordinaria y ponerla en lugares ordinarios con trabajos ordinarios y obtener gloria extraordinaria para Sí mismo. ¡Eso sí que es un trabajo importante!Ef. 6:5 To support this ministry financially, visit: https://www.oneplace.com/donate/276/29

A powerful EF-3 tornado with winds of up to 150 miles per hour tore through St. Louis -- killing at least five people and damaging up to 4500 buildings. As St. Louisans pick up the pieces, there are still many unresolved issues.

¿Sientes que lo único que hace es simplemente respirar y trabajar? Bueno el PLAN de Dios es tomar GENTE ordinaria y ponerla en lugares ordinarios con trabajos ordinarios y obtener gloria extraordinaria para Sí mismo. ¡Eso sí que es un trabajo importante!Ef. 6:5 To support this ministry financially, visit: https://www.elsitiocristiano.com/donate/276/29

¿Sientes que lo único que hace es simplemente respirar y trabajar? Bueno el PLAN de Dios es tomar GENTE ordinaria y ponerla en lugares ordinarios con trabajos ordinarios y obtener gloria extraordinaria para Sí mismo. ¡Eso sí que es un trabajo importante!Ef. 6:5 To support this ministry financially, visit: https://www.oneplace.com/donate/276/29

N Engl J Med 1997;336:525-33Background: Digoxin is a natural drug that comes from the Foxglove plant (Digitalis purpurea). It has been used for the treatment of congestive heart failure for over 200 years. At the time this trial was undertaken, it was given to the overwhelming majority of patients with severe congestive heart failure. The percentage of patients on digoxin was over 90% in all of the seminal heart failure trials we have reviewed thus far. However, despite its frequent use, it was unknown whether the drug improved major morbidity or mortality, and new drug classes were emerging with positive effects on hard outcomes. The primary aim of the Digitalis Investigation Group was to design a large, pragmatic trial to test the long-term effect of digoxin versus placebo on all-cause mortality as well as hospitalization for heart failure.Cardiology Trial's Substack is a reader-supported publication. To receive new posts and support our work, consider becoming a free or paid subscriber.Patients: The study enrolled 6,800 patients with congestive heart failure and an EF of 45% in an ancillary trial. The patient population in the trial was intended to be diverse with no upper age limit. If patients were already on an ACE inhibitor, and had been stable for at least 2 weeks, they could be randomized immediately. For patients not on an ACE inhibitor, they were prescribed the drug and reevaluated in 2 weeks, at which time they could be randomized, if stable. Patients could be randomized into the trial whether they were taking digoxin or not and there was no washout phase.Important exclusion criteria included an MI, cardiac surgery or percutaneous coronary intervention within 4 weeks; unstable or refractory angina for less than 1 month; 2nd or 3rd degree AV block or sick sinus syndrome without a pacemaker; atrial fibrillation or atrial flutter; cor pulmonale; acute myocarditis; amyloid cardiomyopathy; hypertrophic cardiomyopathy; complex congenital heart disease; current treatment with IV inotropes; potassium 5.5 mmol/L; need for cardiac surgery or percutaneous coronary intervention in near future; patients on heart transplant list; severe kidney (Cr >3.0 mg/dL) or liver disease; any non-cardiac disease that shortens life-expectancy to

Toni Wahrstätter outlined the trade-offs of EIP-7928. The EF introduces the Trillion Dollar Security initiative. BTCS secures up to $58 million to buy ETH. And EigenDA V2 goes live on testnet. Read more: https://ethdaily.io/703 Disclaimer: Content is for informational purposes only, not endorsement or investment advice. The accuracy of information is not guaranteed.

A daily update on what's happening in the Rocket Pool community on Discord, Twitter, Reddit, and the DAO forum. #RocketPool #rpl #Ethereum #eth #crypto #cryptocurrency #staking #news Podcast RSS: https://anchor.fm/s/cd29a3d8/podcast/rss Anchor.fm: https://anchor.fm/rocket-fuel Spotify: https://open.spotify.com/show/0Mvta9d2MsKq2u62w8RSoo Apple Podcasts: https://podcasts.apple.com/us/podcast/rocket-fuel/id1655014529 0:00 - Welcome Rocket Pool news0:45 - Huge rETH incentives https://x.com/AerodromeFi/status/1922677185623814597 https://x.com/coinbaseduck/status/1922683313896005880? Staking news 3:37 - Gravita send RPL rewards https://discord.com/channels/968587363536220252/968608014116466698/1372223709208907888 Ethereum news 4:34 - Ethereum "Strategy" play https://x.com/NasdaqBTCS/status/1922630511471530303 https://x.com/Charles_BTCS/status/1922630513581265046 https://x.com/drjasper_eth/status/1922645684542427303 8:46 - Trillion dollar security https://blog.ethereum.org/en/2025/05/14/trillion-dollar-security https://x.com/ethereumfndn/status/1922632702097801229 https://x.com/zachobront/status/1922667866211397887 https://x.com/bogdanoffi/status/1922651919157448747 https://x.com/iamDCinvestor/status/1922664340974375094 12:50 - Protocol research call agenda https://x.com/adietrichs/status/1922368467631587636?14:27 - EF org chart https://x.com/0xstark/status/1922642395654394082 16:44 - Curve frontend update https://x.com/CurveFinance/status/1922664429646184482 17:27 - Punks IP sold https://x.com/nodefnd/status/1922291376533995555 20:04 - TradFi talking about Ethereum https://x.com/matt_hougan/status/1922704807204471245

En este mensaje tratamos el caso de un hombre que «descargó su conciencia» de manera anónima en nuestro sitio www.conciencia.net y nos autorizó a que lo citáramos, como sigue: «Hace menos de un año me casé. Amo a mi esposa... pero hemos tenido problemas, ya que cuando hay algo que nos disgusta y nos hace pelear, intento resolver para no dejar que pase y poder dormir con tranquilidad y en [armonía]. Pero ella se queda callada en vez de resolver, y eso me molesta mucho, por lo que me hace actuar de mala manera, no pegándole pero sí ignorándola en varias ocasiones. »¿Cómo puedo hacer, o cuál es la manera para que yo pueda hablar con ella sin disgustarnos? ¿Cómo puedo llevar una conversación sin herirla?» Este es el consejo que le dimos: «Estimado amigo: »... Por lo general, las mujeres y los hombres responden al conflicto de modos distintos. Algunos expertos dicen que el promedio de palabras dichas cada día por las mujeres llega a veinticinco mil, mientras que el promedio entre los hombres es de sólo diez mil palabras al día. Las mujeres son propensas a querer hablar acerca de sus emociones y de los pormenores de cada situación, mientras que los hombres tienden a querer ir al grano, identificar el problema y resolverlo cuanto antes. Ni una ni otra alternativa es la correcta o la incorrecta, sino que entre los cónyuges debe haber acuerdos. »Cuando una mujer (o un hombre) se niega a hablar acerca de un problema, por lo general hay algo del pasado que está afectando esa conducta presente. Muchas veces las mujeres no hablan porque se han dado cuenta de que los hombres en realidad no quieren oír todos los pormenores ni las emociones. Y sin embargo ellas pudieran convencerse de que no se vislumbra ninguna solución del problema sin exponerse al proceso de expresar sus sentimientos y de ser oídas y comprendidas por su esposo. Los esposos no quieren más que resolver los problemas y evitarse todo el parloteo.... »Nosotros estamos totalmente de acuerdo con el principio bíblico que dice que no debemos permitir que el sol se ponga estando aún enojados.1 Al principio de nuestro matrimonio, tratamos de resolver todo conflicto antes de dormirnos cada noche. ¡Sí que perdimos sueño! Un día nos dimos cuenta de que podíamos dormirnos sin haber llegado todavía a un acuerdo, pero no sin antes habernos pedido perdón el uno al otro por palabras que nos habíamos dicho enojados y habernos puesto de acuerdo sobre una hora del día siguiente en que volveríamos a tratar el asunto. Aprendimos que podíamos superar nuestro enojo y concentrarnos en solucionar el problema específico. »En cada discusión, las parejas pueden mostrarse respeto mutuo por sus opiniones particulares respectivas, emplear palabras amables, y escuchar sin interrumpir, aun cuando no estén de acuerdo en los pormenores. Tal vez requiera meses de práctica de estos principios sencillos, pero si se dedica a hacerlo, su esposa tarde o temprano comenzará a comunicarle sus pensamientos y sus sentimientos. »Le deseamos lo mejor, »Linda y Carlos Rey.» El consejo completo, que por falta de espacio no pudimos incluir en esta edición, se puede leer si se pulsa el enlace que dice: «Caso 123» dentro del enlace en www.conciencia.net que dice: «Casos». Carlos ReyUn Mensaje a la Concienciawww.conciencia.net 1 Ef 4:26

When you learn that your child has executive functioning deficits that need strengthening, it can feel confusing and overwhelming. How do you know when your child's lagging EF skills are getting in the way? Nanika explains what executive functioning is and everyday fun and useful ways to help your child improve their capacities to think before acting.Have a parenting question? Email us at parenthood@quickanddirtytips.com or leave a voicemail at 646-926-3243.Find Project Parenthood on Facebook and Twitter, or subscribe to the Quick and Dirty Tips newsletter for more tips and advice.Project Parenthood is a part of Quick and Dirty Tips.Links: https://www.quickanddirtytips.com/https://www.quickanddirtytips.com/subscribehttps://www.facebook.com/QDTProjectParenthoodhttps://twitter.com/qdtparenthood

Este é o nosso episódio 227 e recebemos Alexandre da Silva Costa para uma conversa sobre Heráclito de Eféso.  Alexandre Costa é professor adjunto do Departamento de Filosofia da Universidade Federal Fluminense (UFF). Possui graduação em História pela Universidade Federal… Leia mais → O post 227. Heráclito de Eféso, com Alexandre Costa apareceu primeiro em filosofia pop.

On Monday, storm chaser Tommy Augustine witnessed something that, as a storm spotter, got the National Weather Service to issue a verified tornado warning: a tornado was on the ground near Jamesville, North Carolina.His video quickly made it online and to television, where it was viewed and analyzed on the Weather Channel by Jim Cantore.However, after some analysis and investigation, the National Weather Service has concluded the tornado's strength was an EF-U, a rare classification on the enhanced Fujita scale.Without any sufficient wind damage, meteorologists could not accurately estimate the storm's strength, making it impossible to give it a more traditional EF ranking.This week on the Carolina Weather Group, we're talking with Tommy Augustine about his drone video and storm chase. We're also joined by WCNC Chief Meteorologist Brad Panovich, who quickly shared Tommy's video in the minutes after it was first recorded.

(Aniversario de la Muerte de José María Heredia) Un cierto avaro compró de manzanas dos o un ciento, y en un oscuro aposento de todos las escondió. El avaro cada día las manzanas visitaba: si alguna podrida hallaba, suspirando la comía.... Su hijo que, según se piensa, radiaba el pobre de hambriento, descubrió con gran contento de su padre la despensa.... La llave, pues, le quitó: abre el cuarto, y entra ansioso. Y su diente vigoroso en las manzanas cebó.... En esto su padre entró, y como le halló comiendo, «¡Ah, bribón! ¿Qué estás haciendo?», furioso le preguntó.... «Si no me entregas, mal hijo, las manzanas, te hago ahorcar.» Sin suspender el mascar, el bribonzuelo le dijo:... «Yo muy bien he procedido; ningún daño os he causado: las podridas he dejado, y las buenas he comido.»1 En esta imitación de Florián que hace el poeta cubano José María Heredia, el avaro que compró las manzanas y las escondió pronto aprendió que Dios las creó para que el hombre las comiera; de lo contrario, se pudren. Para mantener oculto su plan egoísta de guardarlas para sí y no compartirlas con nadie, tuvo que comerse las que se iban pudriendo, no fuera que el olor de ellas lo delatara. Su hijo le sacó la partida cuando descubrió el escondite de las manzanas y comenzó a comerse las buenas. Aun cuando el padre acaparador lo pescó en el acto y quiso condenarlo sin piedad, el hijo tenía toda la razón al contestarle tranquilamente que no estaba sino haciéndole el favor de comerse las buenas antes que se pudrieran. Así su padre mezquino no tendría que pasar el suplicio de comerse esas mismas manzanas cuando estuvieran podridas. Definitivamente a ese padre avaro «le salió el tiro por la culata». La moraleja de ese cuento en verso se halla en esta estrofa del poema jocoso del mismo autor titulado Le cayó la lotería: avaro que el talego debajo de tierra esconde, y se lo roban de donde enterrado lo tenía, le cayó la lotería.2 Aquí la expresión «le cayó la lotería» significa todo lo contrario a «se ganó la lotería». Tal vez haya influido en Heredia la enseñanza de San Pablo de que por la avaricia, que es idolatría, viene el castigo de Dios.3 El avaro es idólatra porque adora sus posesiones. Y el único digno de nuestra adoración es Dios.4 No es de extrañarse entonces que el apóstol Pablo también asevere que «ni los ladrones ni los avaros... heredarán el reino de Dios.»5 Es decir, tanto al ladrón del cuento como a su miserable víctima les espera el mismo fin. Más vale que adoremos únicamente a Dios, dándole oportunidad a su Hijo Jesucristo a que reine en nuestro corazón en lugar de las cosas de este mundo. Sólo así podremos asegurar la entrada en el reino de los cielos. Carlos ReyUn Mensaje a la Concienciawww.conciencia.net 1 José María Heredia, «Cuento», Obra poética, Edición crítica de Ángel Augier (La Habana: Editorial Letras Cubanas, 1993), pp. 308-09. 2 Heredia, «Le cayó la lotería», pp. 307-08. 3 Col 3:5-6 4 Éx 20:3-5 5 1Co 6:10; Ef 5:5

Muito bem (3x), está no ar mais um BTCast, o seu podcast de Bíblia e teologia! No episódio de hoje, Rodrigo Bibo e Guilherme Nunes conversam sobre Dons Ministeriais na Carta aos Efésios. Esse é um assunto que divide muitas tradições, já que muitas interpretam a lista do apóstolo Paulo de uma maneira diferente. Mas será […] O conteúdo de Dons Ministeriais – BTCast 601 é uma produção do Bibotalk - Teologia é nosso esporte!.

Muito bem (3x), está no ar mais um BTCast, o seu podcast de Bíblia e teologia! No episódio de hoje, Rodrigo Bibo e Guilherme Nunes conversam sobre Dons Ministeriais na Carta aos Efésios. Esse é um assunto que divide muitas tradições, já que muitas interpretam a lista do apóstolo Paulo de uma maneira diferente. Mas será […] O conteúdo de Dons Ministeriais – BTCast 601 é uma produção do Bibotalk - Teologia é nosso esporte!.

N Engl J Med 1991; 325:303-10Background Enalapril was found to be superior to placebo for patients with severe, class IV heart failure in the CONSENSUS trial and the regimen of Hydralazine-Isosorbide dinitrate was found to be superior to Prazosin as well as placebo for stable patients with mild heart failure in the original V-HEFT I trial. No sufficiently powered trials in this space had been performed to assess whether Enalapril improved long-term morbidity or mortality for heart failure patients with milder symptoms and the CONSENSUS trial had important limitations. The V-HEFT II trial was undertaken to compare 2 vasodilator regimens (Enalapril and Hydralazine-Isosorbide dinitrate) in patients with chronic congestive heart failure. Besides comparing efficacy of these agents on mortality, investigators sought to understand how these agents affected physiologic endpoints. The trial was sponsored by the Veterans Administration and enrolled men and the patient population and methods were identical to the original V-HEFT trial.Cardiology Trial's Substack is a reader-supported publication. To receive new posts and support our work, consider becoming a free or paid subscriber.Patients Men between the ages of 18 and 75 were recruited from 13 participating Veterans Administration hospitals and had to have chronic congestive heart failure based on either evidence of cardiac dilatation or left ventricular dysfunction (EF

Ethereum Foundation's new Co-Executive Directors, Tomasz Stanczak and Hsiao-Wei Wang, join Bankless to outline their vision for the future of Ethereum. We explore their backgrounds, the changing leadership at EF, and the roadmap ahead—from accelerating L1 scaling and improving UX to making Ethereum more dynamic and product-focused. This episode offers a rare behind-the-scenes look at how Ethereum plans to stay resilient, decentralized, and mission-aligned in a fast-changing world. ------

  Ismael Cerna era sobrino del Mariscal Vicente Cerna, quien había sido depuesto como presidente de Guatemala. Ismael empleaba sus dotes de poeta para combatir, mediante la prensa y otras actividades, al entonces presidente, el general Justo Rufino Barrios. Lo cierto es que no comulgaba en absoluto con el régimen de Barrios. Tanto insistió en atacarlo el joven Cerna, que el presidente Barrios resolvió mandarlo a la cárcel por actividades subversivas. En la cárcel el joven poeta, inspirado por quién sabe qué, le envió un nuevo poema al presidente en el que lo calificaba de tirano. Y como si eso fuera poco, retó a Barrios a que le quitara la vida. El presidente, después de leer el poema detenidamente, mandó llamar al poeta para que se lo leyera en voz alta. Cerna no se acobardó, sino que lo hizo con la voz vibrándole de emoción. Barrios quedó admirado de la actuación del poeta y le dijo: —Estos versos no son malos, joven. Cerna replicó: —Si son buenos o malos no lo sé, puesto que sólo los he sentido. Barrios le preguntó entonces: —¿Le gustaría estar libre? Pero Cerna le contestó: —A usted no le pido nada. —Está bien —concluyó Barrios—, está libre. ¡Váyase! La historia me hará justicia aunque usted no lo haga. Cerna salió de la cárcel y también del país en exilio voluntario, y no volvió sino hasta después de la muerte de Barrios. Pero no se quedó callado. En un aniversario de la muerte del exmandatario, aprovechó la ocasión para subir a la tribuna y recitar los siguientes versos: Yo que de tu implacable tiranía una víctima fui, yo que en mi encono quisiera maldecirte todavía, no olvido que en un instante en tu abandono quisiste engrandecer la patria mía, y en nombre de esa patria te perdono.1 Tal vez haya influido en Ismael Cerna el siguiente consejo que San Pablo les dio a los efesios: «Abandonen toda amargura, ira y enojo, gritos y calumnias, y toda forma de malicia. Más bien, sean bondadosos y compasivos unos con otros, y perdónense mutuamente, así como Dios los perdonó a ustedes en Cristo.»2 Todos necesitamos el perdón, tanto el darlo como el recibirlo. Los que no somos perdonadores somos perdedores. Y los que no recibimos el perdón de Dios perdemos la vida eterna que Él nos dio al morir en la cruz. Para recibir ese perdón divino y la vida eterna que lo acompaña, basta con que oremos el padrenuestro así como Cristo nos enseñó que hiciéramos: «Padre, ... perdónanos nuestros pecados, porque también nosotros perdonamos a todos los que nos ofenden.»3 Carlos ReyUn Mensaje a la Concienciawww.conciencia.net 1 Óscar Hugo Álvarez Gómez, Anécdotas del General de División Don Justo Rufino Barrios, 2a ed. (Guatemala: Editorial del Ejército, 1984), pp. 65-66. 2 Ef 4:31‑32 3 Lc 11:4

[@4 min] Alright, this week…THE Klaus Mäkelä takes a Free Throw. That's right folks. We're the only opera podcast to get an exclusive with the phenom Finnish conductor – for a whole 45 seconds! [@9 min] And since we're taking a dip into the symphonic world with our new friend of the show Klaus Makela, stick around for the return of Spring Training for Your Ears: Symphonic Repertoire! [@40 min] Then, a field report on the Met's Marriage of Figaro conducted by Joana Mallwitz (yo-AN-na MAHL-vits) with a very special Barbarina. [@43 min] Plus, in the ‘Two Minute Drill'…Detroit Opera risks being deported and Sir Bryn Terfel says, EF it, I'm going to Mexico. GET YOUR VOICE HEARD operaboxscore.com facebook.com/obschi1 operaboxscore.bsky.social

N Engl J Med 1986; 314:1547-52Background Into the mid-1980's, digoxin and diuretics were the mainstay of chronic disease management for congestive heart failure. Vasodilator agents were also commonly used based on limited data of their favorable hemodynamic effects. No sufficiently powered trials in this space had been performed to assess whether administration of vasodilators or any other agents improved long-term morbidity or mortality for heart failure patients. The V-HEFT trial was undertaken to test the hypotheses that 2 widely used vasodilator regimens (prazosin or a combination of hydralazine and isosorbide dinitrate) were superior for reducing death versus placebo. The trial was sponsored by the Veterans Administration and only enrolled men.Patients Men between the ages of 18 and 75 were recruited from 11 participating Veterans Administration hospitals and had to have chronic congestive heart failure based on either evidence of cardiac dilatation or left ventricular dysfunction (EF 0.7 ng/mL and euvolemic volume status. Clinical evaluations and exercise-tolerance tests on 2 consecutive visits, two weeks apart, had to reveal clinical and exercise stability before randomization could occur. Following randomization, patients continued to receive the optimal dose of digoxin and diuretic along with 1 of 3 study regimens. The placebo group was given placebo tablets and placebo capsules and instructed to take them 4 times a day. The prazosin group took 2.5 mg prazosin capsules and placebo tablets 4 times a day. The hydralazine-isosorbide dinitrate group took 37.5 mg hydralazine capsules and 20 mg isosorbide dinitrate tablets 4 times a day.In all groups, therapy began with 1 capsule and 1 tablet to be taken 4 times a day. In the absence of side effects, this was increased to 2 capsules and 2 tablets 4 times a day for a total of 20 mg of prazosin or 300-160 mg of hydralazine-isosorbide dinitrate. If drug-related side effects occurred, the dose could be reduced to half a tablet 4 times per day or to one capsule 2 times per day. If the dose was reduced, an attempt was made later to reinstitute the full dose.In order to limit dropouts, rigorous criteria were established for “treatment failures.” Physicians were advised to hospitalize patients with worsening symptoms, and, if appropriate, to use temporary intravenous vasodilator or inotropic interventions for stabilization. Physicians were encouraged to resume study medications upon discharge. At least 2 such hospitalizations were required, along with objective evidence of deterioration, before the study medications were discontinued and replaced with known therapy.Endpoints The primary endpoint was all-cause mortality.Results 642 patients were enrolled (273 in placebo group, 183 in prazosin group and 186 in the hydralazine-isosorbide dinitrate group). Excluding discontinuations that took place within 1 month before death, 47 patients (17%) discontinued one or both types of placebos, 43 patients (23%) discontinued prazosin, and 60 patients (32%) discontinued either one or both drugs in the hydralazine-isosorbide group. Six months after randomization, the average prescribed doses were 18.6 mg per day of prazosin, 270 mg per day of hydralazine, and 136 mg per day of isosorbide dinitrate. More than 85% of the prescribed drugs were taken in each treatment group.The mean follow-up was 2.3 years (range 6 months to 5.7 years). Only 4 patients were lost to follow up (2 in placebo group, 1 in prazosin group, and 1 in hydralazine-dinitrate group). There were 120 deaths in placebo group (44%; 19 per 100 patient years), 91 in the prazosin group (50%; 22 per 100 patient years), 72 in the hydralazine-dinitrate group (39%; 17 per 100 patient years). A reduction in mortality over the entire follow-up period was observed in the hydralazine-nitrate group compared with placebo (p = 0.093 on the log-rank test and p = 0.046 on the generalized Wilcoxon test, which gives more weight to treatment differences occurring in the earlier part of the mortality curves and less weight to the latter part, where the numbers are smaller). The absolute difference in mortality between these groups increased during three years and then began to diminish. The absolute difference in mortality between the placebo group and hydralazine-isosorbide groups at years 1 through 4 was 7%, 9%, 11% and 4%, respectively.Prespecified subgroup analysis in CAD vs no CAD stratification showed no significant treatment effect heterogeneity for hydralazine-nitrate among those with CAD although the absolute difference in mortality between groups was numerically higher for patients with CAD.At 8 weeks and 1 year, SBP (-4.1 and -4.6 mmHg) and DBP (-3.2 and -2.7 mmHg) decreased the most in the prazosin group compared to placebo. Hydralazine-nitrate was not associated with a statistically significant nor clinically significant difference in BP with exception of DBP at 8 weeks. The EF rose significantly at 8 weeks and 1 year in the hydralazine-nitrate group (+2.9 and +4.2) compared to placebo but not in the prazosin group.Side effects were reported in 4.0% of placebo patients, 11% of prazosin patients and 19% of hydralazine-nitrate patients, respectively. The most common side effects were headache and dizziness. Headache was reported in 12% of hydralazine-nitrate patients.Conclusions This study compared the combination of hydralazine-isosorbide dinitrate or prazosin to placebo in patients with chronic congestive heart failure who were optimized on digoxin and diuretic therapy. In what appears to be a young (58 years) and highly selected population of clinically stable, male veterans with dilated cardiomyopathies and low symptom burdens, the combination of hydralazine-isosorbide reduced death by 2 per 100 patient years, increased EF by 4% at 1 year and did not significantly alter BP compared to placebo. Side effects were reported in approximately 1 out of 5 patients with the most common being headache and approximately 1 out of 3 discontinued 1 or both study drugs. Prasozin did not reduce death or increase EF but did reduce BP compared to placebo. The internal validity of the study is high with only a few minor imbalances in baseline characteristics, which do not appear clinically relevant nor to consistently favor any one group. Less than 1% of patients were lost to follow up with no significant imbalances between groups. The external validity is limited by the fact that this is a population of male veterans and the etiologic distribution of cardiomyopathy and heart failure is likely different from a general heart failure population; etiologic causes of death are also likely to be different. Furthermore, the population is highly selected and its unclear how many patients from the general heart failure population would meet study criteria.Cardiology Trial's Substack is a reader-supported publication. To receive new posts and support our work, consider becoming a free or paid subscriber. Get full access to Cardiology Trial's Substack at cardiologytrials.substack.com/subscribe