Podcasts about vcl

♦ Reverse Bass Hardstyle Mix by Hardtonic ♦ December 2024 ♦ 320 kbps Audio ♦ Tracklist: 001 - VCL x Creeds x DXPE - Radical Experience (Original Mix) 002 - JAGGER - Doxa (Original Mix) 003 - JAGGER & Piccolø - How You Are (Original Mix) 004 - GYKO - Hypnotic Waves (Original Mix) 005 - Simox & Trypdø - Burning Up (Extensed Mix) 006 - Liberato - Pretend (Simox Remix) 007 - Simox - Distorted Mind (Original Mix) 008 - Trypdø x Carlo Kalu - Green Stuff (Original Mix) 009 - Gigi D'Agostino - Bla Bla (LJH Remix) 010 - LJH - Strike First (Original Mix) 011 - Diction DJ & Sam Dillon - The Cube (Original Mix) 012 - Diction DJ & Sam Dillon - The Pope Loves (Original Mix) 013 - Sizem - Digital Overload (Original Mix) My Fan Page Facebook : www.facebook.com/Hardtonic

Every year, nearly three lakh students flock to the city of Kota in Rajasthan, the coaching capital of the country. Almost half of them enroll themselves at Allen Career Institute, a 36 year-old pioneering coaching centre that was last valued at over 1 billion dollars.Lately, Kota's reputation has been under question because of the frequent student suicides.This has obviously affected the number of students coming in and for the first time in its history, the coaching giant Allen is seeing a fall in its admissions. And its no small dip. Admissions have dropped by over 35% to around 80,000. But here's the interesting part. This isn't restricted to Allen institute in kota alone. Its happening in other cities too.Actually two years ago, VCl investment firm Bodhi Tree Systems came into the picture and Allen began expanding the number of campuses outside Kota. Now, in total, there are over 200 of them and at least, one-third are new. The company's CEO Nitin Kukreja told The Ken that Allen entered 16 new cities like Patna and Lucknow last year alone. A senior teacher at Allen Kota told us that for a centre to be profitable, it needs at least 4,000–5,000 student enrolments. But right now, Allen is not even seeing half of this. At least half a dozen senior Allen staffers and competitors told The Ken that a big chunk of these new centers are losing money. Staff pays have taken a hit but Allen is also hiring staff in new cities with a possible plan of shifting base out of Kota.In today's episode we take a look at what's happening inside one of the country's latest test prep giants.Tune into to Two by Two's latest episode, 'Delhi pricked the Bengaluru bubble' here

When it comes to managing Cost of Goods Sold, it's critical to have a strategy for tracking and reducing expenditures – which is why our Veterinary Care Logistics community always has lots of questions on the topic! It's also why we're all about COGS on this episode of Inventory Nation when Host Nicole Clausen shares her step-by-step approach to securing your clinic's all-important bottom line. We're looking at how to define your clinic's operational profile and understand the best practices necessary to put your team on solid ground. It's after that, says Nicole, that inventory managers can really start to dig deep and pinpoint why costs might be high, where adjustments to spending versus revenue can be made and how to bring your overall equation into perfect balance. Managing COGS isn't just about trying to spend less! The Holy Grail of COGS combines both reducing expenditures and generating revenue for your entire veterinary clinic's long-term bottom-line health. Get the overview of what factors determine your practice's individual profile and which key performance indicators to track. Not for nothing, Nicole has been dubbed “the COGS Queen” by her admirers. Tune into this breakdown and you'll know why – and be inspired to keep coming back for more!Don't forget that June 5th is Inventory Manager Appreciation Day! Celebrate that person who keeps things humming along at your veterinary practice – even if it means celebrating yourself!Would you like to learn more about Inventory 911 Toolkit, our blueprint for helping inventory managers optimize knowledge, strategy and confidence? Click here!You can also join our virtual neighborhood for inventory managers and other veterinary professionals for free by visiting this link.ABOUT VCL:Veterinary Care Logistics serves veterinarians and their teams who are frustrated that their current inventory system is not functioning correctly and are facing out of control inventory costs and improperly stocked hospitals. VCL helps veterinarians through inventory analysis, comprehensive step-by-step action plans, and thorough team member training. My clients experience great success and rave about my work because I roll up my sleeves and get dirty working with your hospital to improve your inventory as if it was my own hospital.FOLLOW OR CONTACT US: Website | LinkedIn | Facebook | Instagram

Soirée spéciale sur France 5 consacrée à l'école publique et à celles et ceux qui l'incarnent : les profs… En première partie de soirée, hommage au réalisateur Laurent CANTET, qui nous a quittés il y a peu, avec son film Entre les murs, chronique quasi documentaire de l'année scolaire d'une classe de 4e dans un collège populaire… Un film qui interroge le statut du prof, les notions d'autorité, de liberté pédagogique… Questions toujours très actuelles dont nous débattrons juste après dans C Ce Soir, en présence de la Ministre de l'Éducation. On en débat avec : Nicole BELLOUBET, Ministre de l'Éducation nationale et de la Jeunesse Delphine GIRARD, Professeure agrégée de lettres, cofondatrice et porte-parole de Vigilance Collèges Lycées (VCL) et vice-présidente du Comité Laïcité République (CLR) Nedjib SIDI MOUSSA, Docteur en science politique, professeur contractuel d'histoire-géographie dans le secondaire, auteur de « Le Remplaçant - Journal d'un prof (précaire) de banlieue » aux éditions de L'Échappée (08.09.23) Louise TOURRET, Journaliste, productrice de l'émission "Etre et savoir » sur France Culture, autrice de « En finir avec les idées fausses sur l'école » aux éditions de l'Atelier (19-04-2024) Marie-Estelle PECH, Journaliste, rédactrice en chef du service Société de Marianne

How did our host, Nicole Clausen, come to be a thought leader for veterinary practices nationwide? On this episode of The Inventory Nation Podcast she shares with us her origin story and lessons learned on her professional journey from logistical overwhelm to veterinary clinic management mastery. We are learning about the “aha” moments and highly successful systems Nicole developed through trial and error, along with roadblocks we can all expect to encounter along the way. You'll hear about Nicole's Top 5 Inventory Gamechangers – practices that she initiated after hard-won lightbulb moments as an inventory management newbie. Don't miss out on predictable speed bumps and things to remember as you take on this highly challenging – but equally rewarding – role. And remember: Your inventory management systems won't be perfect right out of the gate. But you WILL reduce chaos and improve quality of life for everyone across your veterinary practice. So be kind to yourself, keep the faith and take notes from Nicole – someone who has been there and is ready to show you the way! Also: Big news! Our Inventory System Deep Dive now offers six hours of RACE-approved continuing education (plus earn a Certificate of Veterinary Inventory Fundamentals) and our Certified Veterinary Inventory Professional Program includes 34 hours of RACE-CE.KEY QUOTES: “In those first days and weeks (in inventory management) I really struggled because I was brand new to the practice and … was truly coming into a blank slate where I had no idea what was going on.” (Nicole)“My brain works best when I have a full picture and I know all the information. I don't really do well when I have to guess and hope for the best.” (Nicole)“Setting up re-order points was the first project that I tackled and it was the thing that moved the needle the most for me … even if I did have to make some iterations.” (Nicole)“The biggest benefit of setting up your inventory systems is just the level of clarity, confidence and predictability where we often have this low-level hum of chaos and uncertainty.” (Nicole)“As inventory managers we're never going to be 100% perfect because there's so many things out of our control. Supply issues. Back orders. We can try to anticipate, but we can't predict everything.” (Nicole)“Remember that the reason we put all this time into setting up inventory systems is so that it's easier, so that we spend less time and save money!” (Nicole)ABOUT VCL:Veterinary Care Logistics serves veterinarians and their teams who are frustrated that their current inventory system is not functioning correctly and are facing out of control inventory costs and improperly stocked hospitals. VCL helps veterinarians through inventory analysis, comprehensive step-by-step action plans, and thorough team member training. My clients experience great success and rave about my work because I roll up my sleeves and get dirty working with your hospital to improve your inventory as if it was my own hospital.FOLLOW OR CONTACT US: Website | LinkedIn | Facebook | Instagram

Une “contre-attaque de la République” pour répondre à une succession de drames impliquant des mineurs ces dernières semaines et dans la continuité du discours de l'exécutif depuis les émeutes de l'été dernier déclenchées par la mort du jeune Naël, tué lors d'un contrôle de police… L'autorité, martelée par le Premier Ministre, qui doit selon lui être de retour à la fois à l'école, dans la rue, dans les tribunaux et dans les foyers français… Nous allons en débattre ce soir : la France a-t-elle besoin d'un sursaut d'autorité ? Et si oui, par quoi doit-il passer ? La philosophie de Gabriel ATTAL, le fameux “Tu casses, tu répares”, “Tu salis, tu nettoies”, est-elle la bonne pour mettre fin à la violence d'une partie de la jeunesse ? Faut-il en finir comme le dit le Premier ministre avec la “culture de l'excuse”et sanctionner les adolescents les plus violents comme des adultes ? Faut-il responsabiliser davantage voire punir les parents dits défaillants ? On en débat avec : Delphine GIRARD, Professeure agrégée de lettres, cofondatrice et porte-parole de Vigilance Collèges Lycées (VCL) et vice-présidente du Comité Laïcité République (CLR) Pierre-Henri TAVOILLOT, Philosophe, maître de conférence à l'université Sorbonne-Paris IV, président du Collège de philosophie Salomé SAQUÉ, Journaliste à Blast, autrice de « Sois jeune et tais-toi » aux éditions Payot (poche) (06.03.24) Jonathan BOUCHET-PETERSEN, Chroniqueur politique à Libération Adama CAMARA, Réalisateur, fondateur de l'association « Sada » Karim BOUAMRANE, Maire PS de Saint-Ouen-sur-Seine, vice-Président de la Seine-Saint-Denis en charge de la culture

Today I am joined by former British Track and road rider now racing for France, Oscar Nilsson-Julien.Oscar grew up in London riding and racing as part of VCL cycling club. We chat about his progression through the youth and junior categories, the people who he raced with and the multiple British National titles he achieved.After competing as part of the GB programme as an Under 23, Oscar decided to make the move to France to join a French road team to help progress his road career. Soon after the move he was invited to join the French National Team and has made huge progress on the Track over the last year.You can find all episodes wherever you get your podcasts. Please like, subscribe and leave a review.You can also follow me on Instagram:  https://instagram.com/cycling.talk.podcastThank you so much for listening and for supporting me and my podcastSee You on the BikeGeorgiaSupport the show

Guest Nick Cicero is an analyst, entrepreneur and growth expert operating at the intersection of digital media and advertising. He made a name for himself in the 2010s when he founded Delmondo, a social video analytics company. Founded in 2014, Cicero quickly established Delmondo alongside established media measurement companies by introducing numerous industry firsts, including the first enterprise analytics solutions for Snapchat, Instagram Stories, and Facebook Live used by clients such as ABC News, the NFL, WWE, Fox, UEFA, Paramount and more. He and Delmondo also co-produced the first Snapchat Branded Long-Form Ad Series with Marriott Rewards. Raising only a single angel investment round, Cicero steered Delmondo into a profitable startup that garnered millions in revenue, hundreds of loyal customers; and set new industry standards culminating in its acquisition by Conviva in 2018. During his time building Delmondo, Cicero was also a cofounder of TVREV, an analyst business reporting on the convergence of TV and digital media. He partnered on TVREV with a who's who list of media executives that all participated in Conviva's angel investment round – Gary Vaynerchuk (VaynerMedia), Jesse Redniss (former WarnerMedia, current founder at Qonsent) and David Beck (current Brightcove COO) – who collectively operated as BRaVe Ventures. Cicero stayed on at Conviva for several years to lead Conviva's social intelligence business in a VP of Strategy role. At Conviva, Cicero focused on extending their portfolio of measurement products that enable video publishers, sports teams, leagues, and streaming TV providers to get a 360-degree understanding of the viewer journey and grow viewership, engagement, and revenue. He departed Conviva in 2022 to pursue consulting opportunities and explore new entrepreneurial endeavors. He joined the ranks of consulting firm Value Creation Labs (VCL) in 2023, establishing himself in a GTM Lead role for VCL and its partners such as Vevo, Precise TV, PadSquad and T-Mobile. Cicero is a regular speaker at industry trade shows, and is an expert commenter on industry trends such as his analysis of the $5 billion Netflix-WWE deal featured in The Drum. He also has a passion for mentoring the next generation of media entrepreneurs. He's an adjunct faculty member at his alma mater, the S.I. Newhouse School of Public Communications at Syracuse University, where he recently announced the formation of the inaugural Emerging Leaders Alumni Board of which he plays a lead role. We explore Cicero's impact on the media innovation community, what he's up to at VCL, and much more in this latest ‘Boston Speaks Up' episode.

La crise à l'école est-elle une crise de l'autorité ? C'est l'avis du ministre de l'éducation nationale Gabriel ATTAL, après les incidents qui se sont multipliés ces dernières semaines : attaques au couteau, profs menacés qui exercent leur droit de retrait, cours contestés par les élèves mais aussi par leurs parents… Alors, face à la dégradation du climat scolaire, aut-il revenir à une éducation à l'ancienne, à l'uniforme, à la sanction, à la verticalité ? Ou ce discours est-il une réponse simpliste, une sorte de “pensée magique” un poil nostalgique, en décalage avec notre époque ? On en débat avec : Jean-Pierre LE GOFF, Philosophe, sociologue, auteur de « Mes années folles - Révolte et nihilisme du peuple adolescent après Mai 68 » aux éditions Robert Laffont (21/09/2023) Lisa KAMEN-HIRSIG, Professeure des écoles, chroniqueuse, autrice de « La Grande Garderie » aux éditions Albin Michel (06.09.23) Camille ROELENS, Enseignement-chercheur en philosophie de l'éducation, auteur de "Quelle autorité dans une société des individus ?" aux éditions Presses Universitaires de Rouen (25.01.24) Delphine GIRARD, Professeure agrégée de lettres, cofondatrice et porte-parole de Vigilance Collèges Lycées (VCL), vice-présidente du Comité Laïcité République (CLR) Jonathan BOUCHET-PETERSEN, Chroniqueur politique à Libération

SUMMARY: There it is: The dreaded “payment due in full at time of service” sign at your front desk. For many pet owners it can make the difference between seeking treatment and walking away. Sad, uncomfortable conversations about the financial bottom line are a huge cause of burnout for care providers, but it doesn't have to be that way! Our special guest on this episode of Inventory Nation is sharing a systematic approach to tailoring a clear, flexible financial strategy that fits your particular practice's values and resources.Aimee St. Arnaud, practice owner and founder of Open Door Veterinary Collective, walks Host Nicole Clausen through a new way of tackling the realities of pet care costs and collaborating to create a win-win financially and emotionally. Her team offers both consultation and courses to help practices put in place practical tools to soften the biggest barrier to care. Clients and practices alike can benefit from Open Door's step-by-step guidance around things like pay-over-time options that put the care pets need within the reach of clients on a budget. You'll come away inspired to explore new online payment platforms, train team members to have frank (but supportive) conversations and put in place a plan that takes into consideration all the variables and modulates spectrum of care and pricing accordingly. It's exciting stuff that can be transformational for practices struggling to find the balance between profitability and compassionate care in an inflationary world!Curious to know more about what the Open Door Veterinary Collective is all about? You can find out about all their resources and partnerships at this link.You can also join the Inventory Strategy Network – our free virtual neighborhood for inventory managers and other veterinary professionals – by visiting this link.KEY QUOTES: “Telling clients that you can't help them because they have no money is one of the leading causes of burnout in the vet profession.” (Aimee)“As many times as you have (the money conversation) it's still heartbreaking. How can we build a bridge to make sure not only that patients are cared for but our teams feel cared for as well?” (Nicole)“Giving (clients) a wealth of options and resources to truly make it a collaboration feels very exciting to me because it's not just a one-way conversation anymore.” (Nicole)“It takes less time to go over these plans with people and present this then it does to deal with when they can't afford the care and they give a negative one-star review.” (Aimee)“As more practices try to do (pay-over-time) and it becomes the norm, it's really going to help break this barrier to care.” (Aimee)ABOUT VCL:Veterinary Care Logistics serves veterinarians and their teams who are frustrated that their current inventory system is not functioning correctly and are facing out of control inventory costs and improperly stocked hospitals. VCL helps veterinarians through inventory analysis, comprehensive step-by-step action plans, and thorough team member training. My clients experience great success and rave about my work because I roll up my sleeves and get dirty working with your hospital to improve your inventory as if it was my own hospital.FOLLOW OR CONTACT US: Website | LinkedIn | Facebook | Instagram

Professor Parosha Chandran is a distinguished, multi-award winning human rights barrister at One Pump Court Chambers in London, a specialist in modern slavery law, and a world-leading expert on the law relating to human trafficking, including for the United Nations, the Council of Europe, and the British Parliament's work for Commonwealth States.She represents victims of modern slavery and human trafficking in their cases and during her 26-year legal career she has set critical trafficking precedents in the Courts with national and global reach, most recently in a landmark judgment on non-punishment of the European Court of Human Rights in 2021, VCL and AN v UK, which concerned trafficked Vietnamese minors wrongly convicted of cannabis cultivation which their traffickers had required them to perform.She works closely with NGOs and international organisations, provides trafficking training, including for judges, lawyers NGOs and prosecutors, and has advised on domestic and international legislation, including aspects of the Modern Slavery Act 2015. She has published two books, including ‘The Human Trafficking Handbook: Recognising Trafficking and Modern-Day Slavery in the UK' (LexisNexis, 2011). She is a co-author of the Council of Europe's comprehensive e-learning course on ‘Combatting Human Trafficking' (2018 & 2023 edition publication pending).In 2015 she received the ‘Trafficking in Persons Hero Award' from John Kerry and the Obama administration for her outstanding work in the field. In 2018 she received the distinction of being appointed the first Professor of Practice in Modern Slavery Law at King's College London where she teaches her own LLM course. In 2021 she represented the UN Special Rapporteur on trafficking in persons in two cases of significance, including in her third party intervention in the Supreme Court in Basfar and Wong, which lifted the diplomatic veil of immunity in a global landmark case concerning a female migrant domestic worker trafficked into the UK for exploitation.Many of her landmark legal cases have involved critical issues concerning race and gender and she highlights these and bring her personal observations on how these impacted victim protection in her talk.This lecture was delivered at the Faculty of Law, University of Cambridge, on 11 May 2023 as part of the series of Law and Race talks.Supported by the Centre for Public Law: https://www.cpl.law.cam.ac.uk/

Professor Parosha Chandran is a distinguished, multi-award winning human rights barrister at One Pump Court Chambers in London, a specialist in modern slavery law, and a world-leading expert on the law relating to human trafficking, including for the United Nations, the Council of Europe, and the British Parliament’s work for Commonwealth States. She represents victims of modern slavery and human trafficking in their cases and during her 26-year legal career she has set critical trafficking precedents in the Courts with national and global reach, most recently in a landmark judgment on non-punishment of the European Court of Human Rights in 2021, VCL and AN v UK, which concerned trafficked Vietnamese minors wrongly convicted of cannabis cultivation which their traffickers had required them to perform. She works closely with NGOs and international organisations, provides trafficking training, including for judges, lawyers NGOs and prosecutors, and has advised on domestic and international legislation, including aspects of the Modern Slavery Act 2015. She has published two books, including ‘The Human Trafficking Handbook: Recognising Trafficking and Modern-Day Slavery in the UK’ (LexisNexis, 2011). She is a co-author of the Council of Europe’s comprehensive e-learning course on ‘Combatting Human Trafficking’ (2018 & 2023 edition publication pending). In 2015 she received the ‘Trafficking in Persons Hero Award’ from John Kerry and the Obama administration for her outstanding work in the field. In 2018 she received the distinction of being appointed the first Professor of Practice in Modern Slavery Law at King’s College London where she teaches her own LLM course. In 2021 she represented the UN Special Rapporteur on trafficking in persons in two cases of significance, including in her third party intervention in the Supreme Court in Basfar and Wong, which lifted the diplomatic veil of immunity in a global landmark case concerning a female migrant domestic worker trafficked into the UK for exploitation. Many of her landmark legal cases have involved critical issues concerning race and gender and she highlights these and bring her personal observations on how these impacted victim protection in her talk. This lecture was delivered at the Faculty of Law, University of Cambridge, on 11 May 2023 as part of the series of Law and Race talks. Supported by the Centre for Public Law: https://www.cpl.law.cam.ac.uk/

Professor Parosha Chandran is a distinguished, multi-award winning human rights barrister at One Pump Court Chambers in London, a specialist in modern slavery law, and a world-leading expert on the law relating to human trafficking, including for the United Nations, the Council of Europe, and the British Parliament’s work for Commonwealth States. She represents victims of modern slavery and human trafficking in their cases and during her 26-year legal career she has set critical trafficking precedents in the Courts with national and global reach, most recently in a landmark judgment on non-punishment of the European Court of Human Rights in 2021, VCL and AN v UK, which concerned trafficked Vietnamese minors wrongly convicted of cannabis cultivation which their traffickers had required them to perform. She works closely with NGOs and international organisations, provides trafficking training, including for judges, lawyers NGOs and prosecutors, and has advised on domestic and international legislation, including aspects of the Modern Slavery Act 2015. She has published two books, including ‘The Human Trafficking Handbook: Recognising Trafficking and Modern-Day Slavery in the UK’ (LexisNexis, 2011). She is a co-author of the Council of Europe’s comprehensive e-learning course on ‘Combatting Human Trafficking’ (2018 & 2023 edition publication pending). In 2015 she received the ‘Trafficking in Persons Hero Award’ from John Kerry and the Obama administration for her outstanding work in the field. In 2018 she received the distinction of being appointed the first Professor of Practice in Modern Slavery Law at King’s College London where she teaches her own LLM course. In 2021 she represented the UN Special Rapporteur on trafficking in persons in two cases of significance, including in her third party intervention in the Supreme Court in Basfar and Wong, which lifted the diplomatic veil of immunity in a global landmark case concerning a female migrant domestic worker trafficked into the UK for exploitation. Many of her landmark legal cases have involved critical issues concerning race and gender and she highlights these and bring her personal observations on how these impacted victim protection in her talk. This lecture was delivered at the Faculty of Law, University of Cambridge, on 11 May 2023 as part of the series of Law and Race talks. Supported by the Centre for Public Law: https://www.cpl.law.cam.ac.uk/ This entry provides an audio source for iTunes.

Professor Parosha Chandran is a distinguished, multi-award winning human rights barrister at One Pump Court Chambers in London, a specialist in modern slavery law, and a world-leading expert on the law relating to human trafficking, including for the United Nations, the Council of Europe, and the British Parliament's work for Commonwealth States.She represents victims of modern slavery and human trafficking in their cases and during her 26-year legal career she has set critical trafficking precedents in the Courts with national and global reach, most recently in a landmark judgment on non-punishment of the European Court of Human Rights in 2021, VCL and AN v UK, which concerned trafficked Vietnamese minors wrongly convicted of cannabis cultivation which their traffickers had required them to perform.She works closely with NGOs and international organisations, provides trafficking training, including for judges, lawyers NGOs and prosecutors, and has advised on domestic and international legislation, including aspects of the Modern Slavery Act 2015. She has published two books, including ‘The Human Trafficking Handbook: Recognising Trafficking and Modern-Day Slavery in the UK' (LexisNexis, 2011). She is a co-author of the Council of Europe's comprehensive e-learning course on ‘Combatting Human Trafficking' (2018 & 2023 edition publication pending).In 2015 she received the ‘Trafficking in Persons Hero Award' from John Kerry and the Obama administration for her outstanding work in the field. In 2018 she received the distinction of being appointed the first Professor of Practice in Modern Slavery Law at King's College London where she teaches her own LLM course. In 2021 she represented the UN Special Rapporteur on trafficking in persons in two cases of significance, including in her third party intervention in the Supreme Court in Basfar and Wong, which lifted the diplomatic veil of immunity in a global landmark case concerning a female migrant domestic worker trafficked into the UK for exploitation.Many of her landmark legal cases have involved critical issues concerning race and gender and she highlights these and bring her personal observations on how these impacted victim protection in her talk.This lecture was delivered at the Faculty of Law, University of Cambridge, on 11 May 2023 as part of the series of Law and Race talks.Supported by the Centre for Public Law: https://www.cpl.law.cam.ac.uk/

Professor Parosha Chandran is a distinguished, multi-award winning human rights barrister at One Pump Court Chambers in London, a specialist in modern slavery law, and a world-leading expert on the law relating to human trafficking, including for the United Nations, the Council of Europe, and the British Parliament’s work for Commonwealth States. She represents victims of modern slavery and human trafficking in their cases and during her 26-year legal career she has set critical trafficking precedents in the Courts with national and global reach, most recently in a landmark judgment on non-punishment of the European Court of Human Rights in 2021, VCL and AN v UK, which concerned trafficked Vietnamese minors wrongly convicted of cannabis cultivation which their traffickers had required them to perform. She works closely with NGOs and international organisations, provides trafficking training, including for judges, lawyers NGOs and prosecutors, and has advised on domestic and international legislation, including aspects of the Modern Slavery Act 2015. She has published two books, including ‘The Human Trafficking Handbook: Recognising Trafficking and Modern-Day Slavery in the UK’ (LexisNexis, 2011). She is a co-author of the Council of Europe’s comprehensive e-learning course on ‘Combatting Human Trafficking’ (2018 & 2023 edition publication pending). In 2015 she received the ‘Trafficking in Persons Hero Award’ from John Kerry and the Obama administration for her outstanding work in the field. In 2018 she received the distinction of being appointed the first Professor of Practice in Modern Slavery Law at King’s College London where she teaches her own LLM course. In 2021 she represented the UN Special Rapporteur on trafficking in persons in two cases of significance, including in her third party intervention in the Supreme Court in Basfar and Wong, which lifted the diplomatic veil of immunity in a global landmark case concerning a female migrant domestic worker trafficked into the UK for exploitation. Many of her landmark legal cases have involved critical issues concerning race and gender and she highlights these and bring her personal observations on how these impacted victim protection in her talk. This lecture was delivered at the Faculty of Law, University of Cambridge, on 11 May 2023 as part of the series of Law and Race talks. Supported by the Centre for Public Law: https://www.cpl.law.cam.ac.uk/

Professor Parosha Chandran is a distinguished, multi-award winning human rights barrister at One Pump Court Chambers in London, a specialist in modern slavery law, and a world-leading expert on the law relating to human trafficking, including for the United Nations, the Council of Europe, and the British Parliament’s work for Commonwealth States. She represents victims of modern slavery and human trafficking in their cases and during her 26-year legal career she has set critical trafficking precedents in the Courts with national and global reach, most recently in a landmark judgment on non-punishment of the European Court of Human Rights in 2021, VCL and AN v UK, which concerned trafficked Vietnamese minors wrongly convicted of cannabis cultivation which their traffickers had required them to perform. She works closely with NGOs and international organisations, provides trafficking training, including for judges, lawyers NGOs and prosecutors, and has advised on domestic and international legislation, including aspects of the Modern Slavery Act 2015. She has published two books, including ‘The Human Trafficking Handbook: Recognising Trafficking and Modern-Day Slavery in the UK’ (LexisNexis, 2011). She is a co-author of the Council of Europe’s comprehensive e-learning course on ‘Combatting Human Trafficking’ (2018 & 2023 edition publication pending). In 2015 she received the ‘Trafficking in Persons Hero Award’ from John Kerry and the Obama administration for her outstanding work in the field. In 2018 she received the distinction of being appointed the first Professor of Practice in Modern Slavery Law at King’s College London where she teaches her own LLM course. In 2021 she represented the UN Special Rapporteur on trafficking in persons in two cases of significance, including in her third party intervention in the Supreme Court in Basfar and Wong, which lifted the diplomatic veil of immunity in a global landmark case concerning a female migrant domestic worker trafficked into the UK for exploitation. Many of her landmark legal cases have involved critical issues concerning race and gender and she highlights these and bring her personal observations on how these impacted victim protection in her talk. This lecture was delivered at the Faculty of Law, University of Cambridge, on 11 May 2023 as part of the series of Law and Race talks. Supported by the Centre for Public Law: https://www.cpl.law.cam.ac.uk/ This entry provides an audio source for iTunes.

Introducing ⁠⁠ITSTEAMIMPACT ⁠⁠ Born in ATLANTA, Powered by ⁠⁠THEIMPACTPLAY⁠⁠ ⁠⁠Learn More: ⁠⁠ ⁠⁠https//www.itsteamimpact.com/⁠⁠ --- This episode of THEIMPACTPLAY is sponsored by ⁠⁠⁠⁠⁠⁠⁠Audible:⁠⁠⁠⁠⁠⁠⁠ Sign up for your free 30-day trial and immediately get access to 1 credit. That is good for any premium title. Simply go to: ⁠⁠⁠⁠⁠⁠⁠audibletrial.com/theimpactplay⁠⁠⁠⁠⁠⁠⁠ -- This is Episode 301 & on the Agenda We Have: An Xbox Games Showcase and Starfield Direct Double Feature, Phil Spencer's Interview with Kinda Funny, The Mix and Guerrilla Collective's Upcoming Showcase, Hogwarts Legacy Has Surpassed a $1 Billion, BlizzCon? A Google and Apple Team-up!? AMD's Ryzen 7040U, Google officially unveil of the Pixel Fold, the Writer's Strike, S.W.A.T. has been Canceled, Mortal Kombat 2, Yellowstone is Ending, the F1 Miami Grand Prix, the NBA Playoffs, Fortnite is Heading to the Olympics, the ESL One Berlin DOTA Major Playoffs, the VCL 2023 South Asia Split, the 2023 Summer Concert Series, 50 Cent's Final Lap Tour, Billboard's Latin Women in Music + the Top Stories of the Week...  Review us on ⁠⁠⁠⁠⁠⁠⁠IMDb:⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠https://www.imdb.com/title/tt23985770/⁠⁠⁠⁠⁠⁠⁠ *** Your Support Keeps the Lights Running and Keeps the Content Rolling. Learn more by joining us on ⁠⁠⁠⁠⁠Discord:⁠⁠⁠⁠⁠ ⁠https://discord.com/channels/403710401990098946/role-subscriptions⁠ You can get access to some exclusive content, including an ad free version of the show, a whole lot of content before everyone else, and more... We are Epic Partners So, for every purchase you make within The Epic Store when you use our Creator Code: THEIMPACTPLAY - We do get a commission that will help support and further elevate the show and even take us to new heights at no added cost! --- --- Show Host(s) : ⁠⁠⁠⁠⁠⁠ITSYAGOOH⁠⁠:⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠https://twitter.com/itsyagooh⁠⁠⁠⁠⁠⁠ *** ⁠⁠⁠⁠Watch:⁠⁠⁠⁠ ⁠⁠⁠⁠https://www.youtube.com/theimpactplay⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠T⁠⁠witch:⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠https://www.twitch.tv/theimpactplay⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠Listen:⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠https://anchor.fm/theimpactplay⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠Discord:⁠⁠⁠⁠⁠ ⁠ h⁠ttps://discord.com/channels/403710401990098946/role-subscriptions⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠Merch:⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠https://www.teepublic.com/stores/theimpactplay?ref_id=11948⁠⁠⁠ --- Send in a voice message: https://podcasters.spotify.com/pod/show/theimpactplay/message Support this podcast: https://podcasters.spotify.com/pod/show/theimpactplay/support

Nesse podcast falaremos um pouco sobre as opções existentes para que possamos traduzir as aplicações VCL em diferentes linguagens. Convidado: Ricardo Boaro, MVP Embarcadero e CEO da GDK Software

SUMMARY: Passion is at the heart of every great romance and it's no different went it comes to Host Nicole Clausen's ongoing affair with all things inventory management! This episode of The Inventory Nation Podcast offers you a front-row seat on what it feels like to Fall In Love With Your Inventory! Returning with her first podcast of 2023 (and since the loss of her beloved Tank), Nicole jumps right into the nuts and bolts of putting systems in place – not just in order to get a handle on things like ordering, pricing and performance indicators but also to make life more pleasant and manageable for everyone on your team. Even on the best of days our practices can be swamped by all kinds of variables, so why not put in place SOPs that are about more than show? Nicole is spelling out the components of a healthy inventory ecosystem and how they all work together to ease everyday operational flow. You'll also hear about Emma and the real-world results she reaped after taking control of her multi-practice inventory management system. With a little help from Nicole and her toolkit, Emma discovered how to make her multiple vet practices hum – and in the process of doing so also uncovered the fact that this kind of work – spreadsheets and all – is actually in her zone of genius! Maybe it's in yours, too? Ready to Fall In Love With Your Inventory? Click here to find out all about Nicole's upcoming free five-day mini-course, a proven process for taking back control of your inventory – without adding a million things to your to-do list!And if you would like to learn more about Inventory 911 Toolkit, the systematic roadmap developed by Veterinary Care Logistics to help inventory managers optimize knowledge, strategy and confidence, click here!You can also join our virtual neighborhood for inventory managers and other veterinary professionals for free by visiting this link.ADDITIONAL RESOURCES:Website for Cornerstone Veterinary Software.Veterinary Care Logistics: @InstagramVeterinary Care Logistics: Certified Veterinary Inventory Professional ProgramVeterinary Care Logistics: Consulting ServicesABOUT VCL:Veterinary Care Logistics serves veterinarians and their teams who are frustrated that their current inventory system is not functioning correctly and are facing out of control inventory costs and improperly stocked hospitals. VCL helps veterinarians through inventory analysis, comprehensive step-by-step action plans, and thorough team member training. My clients experience great success and rave about my work because I roll up my sleeves and get dirty working with your hospital to improve your inventory as if it was my own hospital.FOLLOW OR CONTACT US:Website | LinkedIn | FOLLOW OR CONTACT US: Website | LinkedIn | Facebook | Instagram

We all know controlled substances are to be handled with care, but Host Nicole Clausen's guest on this episode of Inventory Nation drives home just how critical it is to mitigate risk – before a breach of compliance occurs! Jack Teitelman, a 26-year veteran of the Drug Enforcement Agency (DEA), has seen first-hand the fall-out for veterinary registrants who fail to put adequate systems in place and it's not pretty. Your program doesn't have to be perfect, but it must demonstrate seriousness of intent and consistency. Feeling fully compliant and ready to face the DEA? If not, you might want to take a short risk assessment quiz to determine whether a discovery call is in order! You can find the link here. Would you like to learn more about Inventory 911 Toolkit, our step-by-step blueprint to help inventory managers optimize knowledge, strategy and confidence? Click here! You can also join our virtual neighborhood for inventory managers and other veterinary professionals for free by visiting this link.ABOUT VCL:Veterinary Care Logistics serves veterinarians and their teams who are frustrated that their current inventory system is not functioning correctly and are facing out of control inventory costs and improperly stocked hospitals. VCL helps veterinarians through inventory analysis, comprehensive step-by-step action plans, and thorough team member training. My clients experience great success and rave about my work because I roll up my sleeves and get dirty working with your hospital to improve your inventory as if it was my own hospital.FOLLOW OR CONTACT US: Website | LinkedIn | Facebook | Instagram

Are you staying ahead of price increases – especially in an economy where the cost of everything seems to be going up, up, up? On this episode of The Inventory Nation Podcast you'll find out why it's more important than ever to have systems in place to prevent three common pricing mistakes that can erode bottom-line revenue. Host Nicole Clausen, founder of Veterinary Care Logistics, is highlighting some of the sneakiest reasons inventory managers often feel like they're scrambling – and still (quite literally) coming up short. She shares key strategies for keeping clinic operations running smoothly – and profitably – with protocols around things like receipt and processing of shipments, maintaining up-to-date practice management systems and setting up backstops for the inevitable pricing outliers and “special exceptions” that can trip us up. The good news is: Nicole has been there and knows what it takes to audit, analyze and help us incorporate gold standard operating procedures that ensure our veterinary inventory practices are optimized – and the headaches minimized!Would you like to learn more about Inventory 911 Toolkit, the powerful step-by-step blueprint to help inventory managers to leverage knowledge and strategy with confidence? Click here!You inquire about VCL's remote consulting services by clicking here or join a free virtual neighborhood for inventory managers and other veterinary professionals by visiting this link.ADDITIONAL RESOURCES:Veterinary Care Logistics: @InstagramVeterinary Care Logistics: Certified Veterinary Inventory Professional ProgramABOUT VCL:Veterinary Care Logistics serves veterinarians and their teams who are frustrated that their current inventory system is not functioning correctly and are facing out of control inventory costs and improperly stocked hospitals. VCL helps veterinarians through inventory analysis, comprehensive step-by-step action plans, and thorough team member training. My clients experience great success and rave about my work because I roll up my sleeves and get dirty working with your hospital to improve your inventory as if it was my own hospital.FOLLOW OR CONTACT US:Website | LinkedIn | Facebook | 

Is your inventory manager empowered to protect your bottom line? If not, then you're leaving money on the table that could be used instead to grow the healthiest, most robust veterinary practice possible! This episode of the Inventory Nation Podcast focuses on all things COGS, which stands for Cost of Goods Sold. Host Nicole Clausen, president and inventory expert at Veterinary Care Logistics, walks us through both definitions and available systems to identify exactly where your practice's costs lie, which when it comes to COGS means anything related to caring for a patient. You'll learn about a great (free!) resource for tracking exactly where these expenditures are and what percentage they represent of your revenue year over year. Having a  methodology in place provides not only a vital measure of your practice's financial health but also a means for reducing costs through lean, intentional, highly effective inventory practices. Wouldn't you rather spend resources on compensating your dedicated team than wasting dollars on expired products, diversion, mischarges, and other inventory-related vulnerabilities? Listen to this episode, and you'll know exactly why the answer is a resounding: Yes! ADDITIONAL RESOURCES:American Animal Hospital Association: Chart of AccountsVeterinary Care Logistics: @InstagramVeterinary Care Logistics: Certified Veterinary Inventory Professional ProgramABOUT VCL:Veterinary Care Logistics serves veterinarians and their teams who are frustrated that their current inventory system is not functioning correctly and are facing out of control inventory costs and improperly stocked hospitals. VCL helps veterinarians through inventory analysis, comprehensive step-by-step action plans, and thorough team member training. My clients experience great success and rave about my work because I roll up my sleeves and get dirty working with your hospital to improve your inventory as if it was my own hospital

Guest Zach Servideo is an entrepreneur and the founder of Value Creation Labs® (VCL), a brand studio-growth accelerator. The 15-year consulting veteran has spent time in Boston, San Francisco and Los Angeles. Known for his boundless energy and storytelling prowess, Servideo is a sought out chief brand officer of sorts for companies looking to elevate their public presence and stoke growth. In 2021, he created VCL as a means to one day realize his vision to own and operate a venture studio. He's currently building toward that goal helping provide flexible consulting services to a range of companies. He also has an investor network betting on those same companies. Servideo nurtures a dynamic VCL talent consortium ranging from artists and writers to patent attorneys and bankers. He's currently working with a group of Boston-based tech journalists on a series of custom analyst reports for Silicon Valley Bank, New England Venture Capital Association, Glasswing Ventures and Accomplice. With Servideo serving as publisher, the reports shed light on innovations from Boston that are hiding in plain sight and yet driving global economic growth. VCL recently released its latest report on cybersecurity. Of course, he's also the founder and host of Boston Speaks Up (BSU), an innovation podcast visiting with inspiring people from all walks of life that is sponsored by Silicon Valley Bank. Founded in 2018, BSU helped catapult Servideo back into the Boston innovation community he spent much of the 2000s and early 2010s in, before a five year stint in Los Angeles. He began his career at Schwartz Communications in the mid 2000s before transitioning to a role at fama PR in 2009 which found him embedded in the Cambridge Innovation Center (CIC) community at One Broadway, Kendall Square. It was at fama/CIC where Servideo began honing the craft of developing brands and taking startups to market – Opower (acquired by Oracle in 2016), Suniva, TweetMyJobs, CloudLock, to name a few. By 2012, he took the entrepreneurial plunge, created his first LLC and developed a business plan to bring his abilities to Los Angeles at a time when ‘Silicon Beach' was just taking off. He spent 5 years between LA and San Francisco bringing companies to market and helping them reach successful exits – Klutch to eBay (2015), Epoxy to Vemba (2016), Watchwith to Comcast (2017), Beachfront Media to PSP Capital (2017), Whosay to Viacom (2018), Downstream to Jungle Scout/Summit Partners (2021) along with several more. For those listeners less familiar with Servideo's work behind the scenes, he's an active business development specialist working on an array of initiatives to support first time founders. For example, he serves as entrepreneur-in-residence at Endicott College's Angle Center for Entrepreneurship where he's a major catalyst behind the school's startup incubator and annual Spark Tank startup competition. He somehow manages to play soccer a couple times a week, coach his daughter's youth soccer team and train/compete in triathlons (with one 70.3 Ironman under his belt).

Le librerie VCL e FMX (FireMonkey) sono utilizzate quotidianamente dagli sviluppatori Delphi in tutto il mondo. Si tratta di mature e robuste librerie per la costruzione di interfacce grafiche (GUI) nello sviluppo di applicazioni business moderne e orientate all'uso da parte dell'utente finale. Cosa c'entra quindi Python in tutto questo? Ebbene, è stato rilasciato un nuovo pacchetto denominato Delphi for Python che comprende i moduli DelphiVCL e DelphiFMX: la potenza delle migliori librerie per GUI ora è nelle mani degli sviluppatori Python! DelphiVCL consente di utilizzare la miglior libreria per lo sviluppo nativo su Windows, mentre DelphiFMX sfrutta la potenza della libreria FireMonkey per creare GUI flessibili e moderne su Windows, Linux, macOS e Android! Grazie a questi nuovi strumenti, il meglio di Delphi entra a far parte del mondo Python (senza che sia necessaria alcuna esperienza precedente con Delphi), affiancando alla sintassi espressiva, al linguaggio di scripting dinamico e a tutte le librerie dell'ecosistema Python una nuova alternativa valida per la creazione di GUI accattivanti, finalmente. Scopriamo di cosa si tratta in questa nuova puntata.

Honest Alice; always a wonderful time. Head down the rabbit hole in a journey through techno space and time. Live Set on 1.24.22 Tracklist: 1. RYSY - 4Get 2. Optimuss - Drive 3. Pfirter - Habitable Zone 4. ID - The Cage 5. ID - Join Us 6. ID - Gesundheit Zuerst 7. Reinier Zonneveld, DYEN - MDMA 8. ID - Hope Reminds Me Of Her 9. Prodigy & ARMA - No Good 10. Jan Vercauteren - Nigel On Acid 11. Michael Katana - Help Me 12. VCL - 90's Feeling 13. Pawlowski - Operation Smackdown

About Today's GuestsDr. Matthew A. Miller, PhD, MPH, is the National Director, Suicide Prevention Program, Office of Mental Health and Suicide Prevention U.S. Department of Veterans Affairs. He leads a team dedicated to the implementation and reinforcement of evidence-based community and clinical interventions addressing suicide prevention. Previously, he served as the Director of the Veterans Crisis Line and under his leadership, the VCL became the world's largest and most efficient suicide crisis call center. Dr. Miller is an Air Force Veteran. He served as a Clinical Psychologist and the Chief of Mental Health at a Joint Services Pilot Training Wing at Wright-Patterson Air Force Base and was responsible for overseeing mental health operations for all active duty service members and dependents, as well as head of the installation's suicide prevention program. Links Mentioned In This EpisodeVA Office of Mental Health and Suicide Prevention2021 National Veteran Suicide Prevention Annual Report Episode 3 of the Seeking the Military Suicide Solution with Dr. MillerPsychArmor Resource of the WeekThe PsychArmor resource for this week is the PsychArmor course series for suicide prevention, intervention, and postvention. Suicide in America is a critical issue, with high rates in service members, Veterans, and their families. Asking the right questions and feeling confident about how to help are the first steps in preventing someone from dying by suicide. We hope these courses will help you to be a lifeline and be there for someone in need.With generous funding from the NFL Foundation, PsychArmor Institute presents a portfolio that promises to provide vital education and information about Suicide Prevention, Intervention, and Postvention for healthcare providers, service members, Veterans, families, caregivers and the community-at-large. You can get to this course series through this link: https://psycharmor.org/suicide-prevention-intervention-postvention/This Episode Sponsored By:This episode is sponsored by PsychArmor, the premier education and learning ecosystem specializing in military culture content. PsychArmor offers an online e-learning laboratory with custom training options for organizations.Join Us on Social Media PsychArmor on TwitterPsychArmor on FacebookPsychArmor on YouTubePsychArmor on LinkedInPsychArmor on InstagramTheme MusicOur theme music Don't Kill the Messenger was written and performed by Navy Veteran Jerry Maniscalco, in cooperation with Operation Encore, a non profit committed to supporting singer/songwriter and musicians across the military and Veteran communities.Producer and Host Duane France is a retired Army Noncommissioned Officer, combat veteran, and clinical mental health counselor for service members, veterans, and their families.  You can find more about the work that he is doing at www.veteranmentalhealth.com  

Dr. Matthew Miller is an Air Force veterans and the Director for Suicide Prevention for the U.S. Department of Veterans  Affairs, where he leads a team dedicated to the implementation and reinforcement of  evidence-based community and clinical interventions addressing suicide prevention,  intervention, and postvention for the Veterans Health Administration (VHA).  Having previously served as the Director of the Veterans Crisis Line (VCL), under his  leadership VCL became the world’s largest and most efficient suicide crisis call center. He  began his VA career as the Chief of Mental Health at Aleda E. Lutz VA Medical Center in  Saginaw, MI, where he later became the Deputy Chief of Staff.  Dr. Miller received his PhD from Michigan State University and a Master of Public Health  (MPH) from the University of Michigan. He completed his professional residency in Clinical  Psychology at Wright-Patterson Air Force Base Medical Center and served as the Chief of  Mental Health at a Joint Services Pilot Training Wing. Dr. Miller was responsible for  overseeing outpatient mental health operations for all active duty service members and  dependents within the installation community. In addition, he was head of the installation’s  suicide prevention, alcohol and drug demand reduction, critical incident response and family  advocacy programs.

Host Vincent Phamvan welcomes VCL guests Gloria Chou, PR expert, Nina Guttierrez, Former CMO and cause-based marketing consultant, and Jessica Gutierrez, VP and cause-based marketing consultant. They discuss branding, consumer engagement, loyalty, PR strategy, and how cause-based marketing is very important in the current and future business market. Join our FREE Marketing Training session THURSDAY at 3:00pm (CT) to learn the top 3 secrets from CMOs! Hear former CMO Vincent Phamvan share the insight from the inner circle that will get you ahead in leveling up your career! Free Marketing Training: Vyten.com/free-training

Host Vincent Phamvan welcomes VCL guest Maya Grossman, a marketing executive with fifteen years of experience taking products to market and driving growth for Fortune 500 companies like Microsoft and Google, as well as fast-growing startups. She is a speaker, a career coach, and most recently the author of Invaluable: Master the 10 Skills You Need to Skyrocket Your Career, an unconventional business book for employees who want to deliver exceptional results.Join our FREE Marketing Training session THURSDAY at 3:30pm (CT) to learn the top 3 secrets from CMOs! Hear former CMO Vincent Phamvan share the insight from the inner circle that will get you ahead in leveling up your career! Free Marketing Training: Vyten.com/free-training

Vincent Phamvan is joined by VCL guest, Tim Busa, who has had a 15-year career in sales and marketing, working across the email marketing, security, and e-commerce industries.  He's currently running marketing at Loop Returns, and prior to that held marketing leadership roles at Zaius, Continuum, and Constant Contact. Join the discussion:https://council.vyten.com/c/live/3-career-lessons-from-15-years-in-sales-marketing

This week I'm talking to Bahrain McLaren's Fred Wright. He has gone through VCL (local club in Dulwich) as a youth and junior combined with the British cycling academy taking him all the way to signing his Neo pro contract last year. We talk about his Baby Giro and L'Avenir stage wins his CCC stagier and his memories of what U23 racing felt like as a first year. I hope you enjoy it! Share and review the podcast.

In todays episode we are joined by Dr. Matt Miller who has a PHD in psychology and the current director of Veterans Administration Suicide Prevention Program.   Our Veterans Crisis Line is available 24/7, however the number is the same as the National Lifeline 1-800-273-8255 – to get to VCL, we would need someone to Press 1. Responders are answering within seconds 24/7. More information is available at veteranscrisisline.net. If you wanted to add the VCL logo to your website so that people see the accurate branding- it’s here: https://www.veteranscrisisline.net/support/shareable-materials . If someone doesn’t need to call the crisis line and want to find the nearest VA medical center, Vet Center, etc. they can go here: https://www.veteranscrisisline.net/get-help/local-resourcesthis also has a national resource directory and the SAMHSA treatment locator. We also have a National Homeless Veterans hotline at: 1-877-424-3838 and website here: https://www.va.gov/HOMELESS/NationalCallCenter.asp   Taking a mental health screening is one of the quickest and easiest ways to determine whether you are experiencing symptoms of a mental health condition. Mental health conditions, such as depression or anxiety, are real, common and treatable. And recovery is possible. To take your Free Mental Health screening visit https://walkthetalkamerica.org/ or click the following link.  TAKE A MENTAL HEALTH TEST We hope you enjoy this episode. Today’s show is brought to you by Audible. Audible is offering our listeners a free audiobook with a 30-day trial membership. Just go to http://www.audibletrial.com/NogginNotes and browse the unmatched selection of audio programs – download a title free and start listening. It’s that easy. Go to http://www.audibletrial.com/NogginNotes Hope you enjoy the podcast and please go ahead subscribe and give us a review of our show. You can write a review on iTunes. 

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.06.29.177758v1?rss=1 Authors: Mandal, P., Belapurkar, V., Nair, D., Ramanan, N. Abstract: Axon growth requires coordination of the actin cytoskeleton by actin-binding proteins in the growth cones of the extending neurites. The actin-binding protein vinculin (Vcl) is a major constituent of focal adhesion but its role in neuronal migration and axon growth is poorly understood. We found that vinculin deletion in mouse neocortical neurons attenuated axon growth both in vitro and in vivo. Using functional mutants of vinculin, we found that various domains of vinculin affect cell migration and axon growth differently. While expression of a constitutively active vinculin significantly enhanced axon growth, the head-neck domain had a moderate inhibitory effect. Contrary to previous findings, vinculin-talin interaction was dispensable for axon growth and neuronal migration. Strikingly, expression of the tail domain delayed neuronal migration and caused increased branching, enlarged soma and highly stunted axon both in vitro and in vivo. Inhibition of the Arp2/3 complex completely reversed the branching phenotype caused by tail domain expression without affecting axon length. Similarly, abolishing the tail domain interaction with actin reversed the enlarged cell soma and branching phenotypes but not axon length. Super-resolution microscopy showed increased mobile fraction of actin in tail domain expressing neurons. Our results provide novel insights into the role of vinculin and its functional domains in regulating neuronal migration and axon growth. Copy rights belong to original authors. Visit the link for more info

Tracks from Steve Shaden, Unbraid, SWART, Dica, Clinical Hates, AD†AM, VCL, Jacidorex, YÅ, Nico Moreno

In questo episodio faremo una carrellata di tutte le novità che troviamo in Delphi 10.4 Sydney, l'ultima versione del nostro ambiente di sviluppo preferito, rilasciato pochi giorni fa da Embarcadero. Approfondiremo assieme tutte le migliorie, le nuove feature e i bug fixing di questa release che interessano diverse aree, quali il supporto LSP per le tecnologie Code/Error/Tooltip Insight, i Custom Managed Records, il ritorno a un modello di gestione della memoria unificato (con l'abbandono di ARC), nuovi controlli, stili particolareggiati e supporto ai monitori High-DPI nella VCL, l'adozione della nuova Metal API per le piattaforme Apple assieme al supporto per lo Storyboard, e ancora novità nell'IDE e nel tool di gestione dei package GetIt, un installer unificato e tanto altro ancora. Qui di seguito sono riportati i link di riferimento di questa puntata: Blog Post di lancio RAD Studio 10.4 Sydney (di Sarina DuPont) Documentazione (wiki) di Delphi 10.4 Sydney Novità di Delphi 10.4 Sydney Introducing RAD Studio 10.4 Sydney (YouTube) Launch Webinar Replay di RAD Studio 10.4 Sydney (YouTube) Nuovo portale Embarcadero per il download Collezione di link e KB su Delphi 10.4 (a cura di Darian Miller - Ideas Awakened, Inc.) Elenco componenti/tool di terze parti per Delphi 10.4 Delphi Live Italia Webinars (by Andrea Magni) Delphi & Dintorni Webinar Replay (by Wintech Italia) Delphi Day 2020 Online

In this episode Andy and Duncan are joined by 2016 National Junior Road Race Champion and Belgium based pro rider Jacob Vaughan. Very much a product of the VCL talent factory at Herne Hill Velodrome in London, Jacob was selected to ride for the junior GB squad at the 2017 World Road Championships in Norway. With many good results along the way Jacob went on to spend seasons with the Lotto - Soudal U23 squad, followed by Canyon DHB p/b Bloor Homes, and his current team in Belgium Indulek-Doltcini-Derito CT - where he scored a win in his third race of the season. All this, and he's still only 20. 

Link to ASI Director Application: https://docs.google.com/forms/d/e/1FAIpQLSeihvaxb19H-3e2j8gUUbIsM1B9EIadQ76UTQg19do3yX24Ag/viewform Link to ASI Judicial Board Application: https://docs.google.com/forms/d/e/1FAIpQLSffoJnbS2N1RRkdrwi2wM4L6YZSF77upyV9N8FltSgvSVP4wA/viewform Link to Virtual Computer Lab: https://its.csub.edu/VCL "Hustle" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/by/4.0/

1972 - Maarten houdt in Münster een lezing over de kerstboom, voor de studenten van Güntermann. Maarten schrijft aan zijn jaarverslag. In de koffieruimte treft hij Tjitske. Tjitske vindt dat je ergens maar vier jaar moet blijven. Gesprek met haar en Wigbold over de kerstboom. Tjitske sneert op het socialisme van Maartens vader. Mia van Idegem voegt zich bij hen. Over een kat die Mia heeft gevonden. Bavelaar vertelt dat Slofstra in een bejaardenhuis gaat. Maarten legt een briefje op het bureau van Jaring en van mevrouw Moederman, met het verzoek de gegevens over het jaarverslag te verschaffen. Mevrouw Moederman verwijt hem het briefje. Hij herinnert zich het kerstspel in het VCL. Met: Joachim Nimtz (Wolf Güntermann), Krijn ter Braak (Maarten Koning), Marcel Musters (Wigbold), Anneke Blok (Tjitske van den Akker), Paul Hoes (Rik Bracht), Marieke van Weelden (Mia van Idegem), Diana Dobbelman (Jantje Bavelaar), Jack Vecht (Geert Meierink), Cas Enklaar (J. de Vries) en Marlies Hamelynck (Mevr. Moederman).

I first ran across Joe Caputo's work during some random YouTubing, where his "Voltage Control Lab" was a real eye-opener - especially for a few under-supported modules like the Ornaments and Crime. Shortly thereafter, I ran into him at the NAMM show, where I got a VCL button from him - and the rest of the history is in the podcast... Joe has pivoted the show into a live show-and-tell-and-interview format, but has also been very active in the educational realm as well - most notably as an instructor at Musician's Institute and Icon Collective. He also continues producing music (as Computo), and... I assume he's taking a nap occasionally or something! In our chat, we talk about education, video production (and production burnout), collaboration and the primacy of music-making. We also talk a bit about 'getting out', sharing your work, and being open to new experiences. Very interesting and inspiring. You can check out his personal thing at https://iamcomputo.wordpress.com/. Voltage Control Lab is at https://www.voltagecontrollab.com/, or on YouTube at https://www.youtube.com/channel/UC9y4nruLDg5DYgzEn8bJxxA. Enjoy!

Suicide postvention is “not something we should wait to talk about,” especially within crisis centers. Proactive training and planning are extremely beneficial to suicide postvention for crisis lines or call centers like the Veteran Crisis Line (VCL). Learn more about what crisis centers do & how crisis centers support their callers, their employees and the agencies they work with in this episode with our host Dr. Sarra Nazem and guests, Greg Hughes, LISCW and Joi Sabrina, LPC from the VCL.

Motor Mayhem presents us with a terrifying glimpse into a post apocalyptic future where the vehicular combat league (VCL) has obliterated all other forms of entertainment. Andy and Biddie delve into the extensive, if not superfluous, lore and try to imagine what could have been upon discovering hidden gems in the ‘DVD extras’.

Nel mese di novembre Embarcadero ha rilasciato Delphi Rio 10.3. Questa nuova versione di Delphi include molte novità, tra le quali un IDE rinnovato con nuovi stili, nuove potenzialità del linguaggio, migliorie nelle performance di RTL e LiveBindings, nuovi controlli della VCL per mimare lo stile delle Universal App anche nelle versioni precedenti di Windows, il supporto più recente per Android e iOS con l'adesione ai nuovi requisiti delle piattaforme e altro ancora. Per conoscere il dettaglio di tutte le novità, non perdetevi l'ascolto di questa puntata e non dimenticatevi di visitare tutti i link di approfondimento riportati qui di seguito: Reportage Delphi Day Padova Edition 2018 (Italiano) Delphi Rio - What's New Delphi Rio - Release Notes Delphi Rio - Installation Notes Delphi Rio - New Features and Fixes Delphi Community Download Embarcadero Academy

yosukepさん、sisidovskiさん、sugimoto1981さん、makogaさんと日経新聞電子版、Fastly、App Engine、PWA、パフォーマンス測定などについて話しました。 経済、株価、ビジネス、政治のニュース:日経電子版 r.nikkei.com Blog — HACK The Nikkei Web SQL Database 日経電子版の“爆速化”を内製で成し遂げた精鋭チームとその手法、効果指標について - ITmedia マーケティング 日経電子版　開発内製化の取り組み / nikkei web development 2015 - Speaker Deck 日経、ＦＴ買収を完了　経済メディアで世界最大に　　：日本経済新聞 Andrew Betts | Principal developer advocate at Fastly and member of W3C TAG 日経電子版 サイト高速化とPWA対応 / nikkei-high-performance-pwa - Speaker Deck How to solve anything in VCL, part 3: authentication and feature flags at the edge Solving anything in VCL PythonでもPythonじゃなくても使える汎用的なMicroservice実行環境 / nikkei microservice - Speaker Deck Labeled Tab-separated Values (LTSV) RUMとA/Bテストを使ったパフォーマンスのモニタリング — HACK The Nikkei Navigation Timing 若者はみんな使っている？　謎のワード「ギガが減る」とは (1/2) - ITmedia NEWS SpeedCurve: Monitor front-end performance A faster FT.com 日経電子版を支える広告技術 — HACK The Nikkei Intersection Observer API - Web APIs | MDN MutationObserver - Web APIs | MDN API gateway pattern Amazon API Gateway（API を簡単に作成・管理） | AWS 生産性を向上させる情報共有ツール - キータチーム（Qiita:Team） Sam Newman - Backends For Frontends google/gvisor: Container Runtime Sandbox Apache Airflow (incubating) Documentation — Airflow Documentation rundeck/rundeck: Enable Self-Service Operations: Give specific users access to your existing tools, services, and scripts Microservices at Mercari ハイパーリンクを貼るだけで著作権料がかかる通称「リンク税」がEUで導入されようとしている - GIGAZINE ASCII.jp：新聞社が「無断リンク」を禁止する3つの理由｜編集者の眼 (2010) Do Not Track - Wikipedia Do Not Track and the GDPR | W3C Blog Intelligent Tracking Prevention 2.0 | WebKit 壁新聞 - Wikipedia 日経のあゆみ : 企業情報 | 日本経済新聞社 テキストの検出 - Amazon Rekognition Vision API - 画像コンテンツ分析  |  Google Cloud 日経テレコン - 新聞・雑誌記事のビジネスデータベース HACK The Nikkei フィードバックもお待ちしております！ https://ajito.fm/form/ または Twitter: #ajitofm までどうぞ。

Curious about the Veterans Crisis Line? Join us for an in-depth conversation with VCL Director Matt Miller about its purpose, history, and what the future holds.  Matt takes us on a journey from VCL's initial launch in 2007, to right now, for the ribbon-cutting of the 3rd call center in Topeka, Kansas. We talk about how VCL has expanded to meet increasing demand, responding to over 2000 calls each day.  Matt tells us about the services VCL offers, who can use them, and how responders are trained to support Veterans and their loved ones. He also walks us through what happens when someone reaches out to the VCL, and explains the follow-up process connecting Veterans with their local VA Suicide Prevention Coordinator. Matt demystifies the crisis line experience and encourages everyone to be familiar with how to contact the VCL before a crisis happens, including saving the number 1-800-273-8255 press 1 into your phone. Tune in to learn about the latest technological advances being pioneered by the VCL, as well as research and continuous quality improvement underway.

I promote the Veterans Crisis Line whenever I can. It is a very important resource to be aware of and I try to remind people however I can. I've used the line to help a friend in need. I encourage everyone to put the number in their phone. 1-800-273-8255 and Press 1 So, in this episode of Borne the Battle, I decided to spotlight the Veterans Crisis Line. In the future, I hope to talk to someone that works there to get their perspective as well. For this week, I explain the different ways you can contact the VCL and the following frequently asked questions: What happens if I don't press 1? Can I use the Veterans Crisis Line even if I'm already receiving care from VA? What mental health services are available from VA? Do I have to give my name or share personal information when I call the Veterans Crisis Line? If I share personal information, will it be kept confidential?

This episode is extra special in that it include a case study of the software behind the lights for Niagara Falls. Nick and I spoke with Martin Searancke of Dream Solutions, Ltd. in New Zealand, who is the architect of the Light Factory software used by the Niagara Falls Illumination Board to illuminate Niagara Falls.  After you listen to the podcast you can read the case study write up here. The software uses both VCL and FireMonkey. The backend control software is written in VCL and the frontend user interface side is written in FireMonkey. It also uses components by Mitov Software, TMS Software, and LMD Innovative. A few links we mentioned Navigator by Parnassus – A fantastic IDE add-in The NEO Phillips Strand Lighting console – The software in the console is by Martin Light Factory – Martin’s web site Here is a little documentary about the new lights at Niagara Falls. It mostly focuses on the hardware side of things, but you can watch it knowing the software comes from your favorite development tools. Niagara Falls Lighting Software Case Study Introduction The decision to upgrade the lighting that illuminates Niagara Falls seems as though it should be the main story but, it’s not. The part of the project we are interested in is the one where the Niagara Falls Illumination Board (NFI) added a requirement to build a more flexible color illumination scheme to replace the old guillotine color-changing scheme that had been in place since 1974. The guillotine color-changing synchro-server mechanical system was to be replaced by a digital color control system and the twenty-one 4000w Xenon lights were to be replaced by 1400 digital-friendly nine-light LED modules in which the LED’s would be multi-color rather than having to place a filter in front of the white light of the Xenons. The LED system of lights would be software controlled from a 22-inch touch screen from over a 2000 foot distance from the falls. The Solution The technical and engineering challenges to a project of this scope and magnitude were significant right down to the last task of choosing the lighting controller and connecting it with the 1400 LED light modules. The software that drives the system is housed in the controller and is built using Embarcadero’s Delphi Integrated Development Environment (IDE). The FireMonkey (FMX) application development platform is used to create the front end functionality, and the Visual Component Library (VCL) is used for the back-end services. FireMonkey and VCL are both integrated elements of the Delphi IDE. The lighting controller was a commercially available machine marketed by Philips Strand Lighting as part of their NEO line of lighting consoles. The existing software code in the NEO lighting console dated back a few years given that the console had been sold commercially before the Niagara Falls lighting project was even considered. The first challenge to overcome was to review the technical and performance requirements needed to accomplish the vision of the NFI and update the FireMonkey and VCL code to meet the required functionality. Then, came the customization of the code to accommodate all the connecting equipment that would drive the LED modules and the end user interface, the 22-inch touchscreen. The overall objective of the new control console and software code within was not to try and upstage the majestic beauty of the falls but rather to organically enhance visual images of the falls at night when it couldn’t be seen otherwise. So, special effects such as strobing and other awe and wow factors were ignored in favor of techniques such as backlighting the falls to reveal hidden beauty in addition to a penetrating forward color-changing illumination. The results were nothing less than magnificent requiring new software profiles due to the color changing properties of the LED modules. The final result was ten preset modes for each side of the Falls (American and Canadian) encompass[...]

This week we're joined by Sydney based producer and rising star VCL in the mix for the second half of the show bringing the unique brand of Deep and Lo-Fi house. First half see's Swervers Alice D, Dr Fiji and ya boi Tom Penny B3B What a time! Check em out; https://www.facebook.com/VCLmusic https://soundcloud.com/vclaurence

Naoya Ito さんをゲストに迎えて、サーバレスアーキテクチャ、Lambda, MBaaS, LINE などについて話しました。 Show Notes ServerlessConf Tokyo Serverless Architectures Can we please rename #serverless to #faas? serverless-conf-agenda/agenda.md 紙面ビューアーを支える サーバーレスアーキテクチャ AWS Lambda - Serverless Compute The Serverless Application Framework AWS Lambda Functions in Go The Twelve-Factor App Solving anything in VCL VCLとAMP〜Frontend Meetup Tokyo Beacon termination at the edge | Fastly Introducing the Realm Mobile Platform Plagger で更新情報を LINE で受け取る plugin plagger docker 化 LINE Notify 1人CTO Night 開発組織マネジメントのコツ

Webby and Boone talk to Bernard Means of the VCL at VCU.

[intro music]   Host – Dan Keller  Hello, and welcome to Episode Five of Multiple Sclerosis Discovery, the Podcast of the MS Discovery Forum. I’m your host, Dan Keller.    This week’s Podcast features an interview with Dr. Anne Cross, who reflects on the past year in MS research. But to begin, here’s a brief summary of some of the topics we’ve been covering on the MS Discovery Forum at msdiscovery.org.    Researchers have discovered that multiple sclerosis may have something in common with colon cancer; the Wnt pathway. It’s a genetic pathway important in development, stem cell maintenance, and cell differentiation. In colon cancer, the mutation of a mediator gene called APC causes the Wnt pathway to become overactive, leading to tumor formation. Now, researchers have discovered that a loss of function mutation of APC in the brain also leads to an overactive Wnt pathway, ultimately freezing oligodendrocyte progenitor cells in their undifferentiated state.    Next, what disease-modifying therapies should women start or stop before pregnancy? In our latest news synthesis, we discuss the difficulties many women with MS have in deciding when to stop DMT before trying to conceive. Since it can take months, and even years, for a woman to conceive, it’s important that she spend the least amount of time off medication as possible to reduce the chance of relapse. Some drugs may be worth taking during pregnancy anyway, but it’s up to the neurologist to do a risk-benefit analysis for each patient. Nevertheless, many women opt to go off of DMT altogether to reduce the risk of adverse effects on the fetus.   Finally, we would like to direct your attention to funding opportunities on the MSDF webpage. Under the Professional Resources tab at msdiscovery.org, you can find a listing of various organizations offering funding for research grants, fellowship grants, and more. Currently, there are several opportunities offered from ECTRIMS with deadlines this winter. There are also several deadlines for funding from the National MS Society coming up in August.    Now for the interview.   Interviewer – Bob Finn This is Bob Finn. I’m here with Dr. Anne Cross of the Washington University in St. Louis. Dr. Cross will later today be giving a talk at the American Academy of Neurology meeting on what the year has been like in MS research. And, so, let me ask you briefly, what has the year been like? Has it been a good year, a bad year, an exciting year, a boring year?   Interviewee – Anne Cross  I think it’s been a pretty good year. There have been some mainly good things, a couple of bad things, some rather interesting and unexpected things, too. I guess some of the good things involve genetics research papers that have come out identifying genes that are associated with risk of developing MS. That’s been kind of exciting. Actually, there were 48 new genes that were identified and published this year by the International MS Genetics Consortium, which is a very large group of international researchers that have amassed probably close to 30,000 genetic samples from MS patients over the years that they’ve been in existence, which is about 10 years, plus close to double that of controls. And all these MS patient samples are from patients who were well characterized and submitted by, generally, MS specialists.    And that group did a study using something called the Immunochip, which is a genotyping array that was actually developed by a group of investigators who work on autoimmune disorders, so that array is very much weighted towards beings with immunologic function. So not too unexpectedly, all 48 of the newest identified genes all relate in some way to the immune system or are very closely linked to genes of immune function. But prior to that, the same group – the International MS Genetics Consortium – had identified about 50, a little over 50 genes that are associated with MS risk, and most of them were also related to genes of immune function. So I think together, all of this data certainly implicates the immune system, which we already knew, but I think things are certainly solidifying around that with the newest data.   MSDF  Let me ask you, if they’re using techniques that are specific for immunological genes, are they missing other genes?   Dr. Cross  They very well could be. The original studies that this group did which were published, the biggest study was published in the summer of 2011, did not do it in that fashion, though, they just did a genome-wide association study, and most of the genes that they identified were related to the immune system directly or indirectly. So, yes, I’m sure that some are being missed that aren’t related to the genes that are on this Immunochip microarray, but they’re trying to hone down a bit.    And some of the other things that were discovered were that, well, they identified 5 allelic variants; the particular allelic variant was over 50% of the time associated with risk of MS. And they also identified in this latest search – well, the strongest association was with a gene that has immune function called Vcl-10 – they actually in this latest search rediscovered the same 50 or so that they had discovered before, so they were actually mostly in this Immunochip microarray.   MSDF  So, aside from the genome-wide association studies, what else has been interesting in MS research this year?   Dr. Cross  Well, I think some of the clinical trials that have been published in the past year, and also that are just ongoing and aren’t published yet, have been interesting. This past week, Dr. Rhonda Voskuhl, who’s from UCLA, spoke and presented for the first time ever recent data from a study of estriol, which is a pregnancy hormone that was added to glatiramer acetate in women with relapsing-remitting MS, and that was compared to placebo pills added to glatiramer acetate. And the results were pretty positive, especially in the first year when there was an almost 50% reduction in relapse rate in the group that received estriol plus glatiramer. And, you know, that’s, of course, based upon longstanding data that we’ve known, that women with MS who have relapsing disease have a much decreased relapse rate during pregnancy. And then Dr. Voskuhl had done a good bit of work with estriol, in particular, which is a fairly safe pregnancy estrogen hormone compared to some of the others, but it’s not available in the United States right now.    MSDF  You mentioned that there were some disappoints.   Dr. Cross  At least for me, and probably for a lot of MS patients, the biggest disappointment was the failure of the FDA to approve a drug called alemtuzumab, which is a humanized monoclonal antibody against an antigen that’s on pretty much all the mononuclear cells of the immune system. And the US FDA failed to approve it, although, I believe, 32 countries and counting have approved it at this point, including Canada and Mexico and all of the countries of Western Europe, Australia, Brazil.   MSDF  Have there been any interesting developments on the remyelination front?   Dr. Cross  Yes, yes, yes. In fact, I hope to speak about that today. There are studies in early-phase trials right now of anti-LINGO-1, which is a humanized monoclonal antibody against a molecule called LINGO-1, which is found only in the central nervous system – at least that’s what the data says so far – and it’s expressed by oligodendroglial cells, or the cells that make central nervous system myelin. And, for whatever reason, it’s involved in inhibiting remyelination in the central nervous system. So the monoclonal antibody that inhibits it then enhances remyelination. And in mouse models it looked very good, and it also led to less injury to axons, or nerve fibers, so it had more than just a remyelinating effect. And it’s now in phase II studies in relapsing-remitting MS and optic neuritis patients. At least the relapsing-remitting MS study is fully enrolled, and so we’ll be looking forward to those results.   So another potential remyelinating agent is a little bit behind anti-LINGO-1. It’s called recombinant human IgM22, and it was developed from a natural IgM antibody that was discovered at Mayo Clinic that binds to a surface antigen on oligodendrocytes – the cells that make central nervous system myelin – and it enhances myelination in mouse models of demyelination, and, in fact, in some studies, just a single dose of that led to longstanding remyelination in the mouse model. So that’s in dose-finding studies in human beings at the present time, and hopefully will move forward from there.   Other exciting things, at least to me, are studies of stem cells that can be differentiated into different types of cells. And, at this point, you can actually take human skin cells or human fibroblasts and revert them back to stem cells; they’re called induced pluripotent stem cells. So you can actually take a person’s skin and do that, and then you can differentiate it forward into whatever cell type you want, really, these days; I mean, you can differentiate them into neurons. And in MS, we’re very interested in differentiating them into oligodendrocyte precursor cells – cells that form the cells that make central nervous system myelin.    And a study that I plan to talk about this afternoon took such cells and made them into human oligodendrocyte precursor cells and put them into the central nervous systems of mice who had a genetic mutation in myelin basic proteins, so they are essentially unmyelinated. And these mice die very soon after being born, much earlier than normal, and they put these human cells in. They had to immunosuppress the mice so that they’d accept the human cells. But these cells actually made myelin, and it was functional myelin at least from the standpoint of wrapping around fairly normal-looking nerve fibers, axons, from the mice, and forming compact, normal-appearing myelin. So that particular group, they’re from New York State and they’re affiliated with several other medical centers, and they plan to get this into humans pretty soon. Their first project, however, is going to involve fetal stem cells first, because that was easier to get approved and moved forward on, and so I believe they’re already funded to do a three-center – all in New York State – stem cell study injecting such cells into the central nervous system of people with secondary progressive MS.    MSDF  Now some patients aren’t waiting for the studies, I understand, but what is your point-of-view about that?   Dr. Cross  It depends on where they’re going and what they’re doing. I personally think there’s some shoddy research, some charlatans you might call them, out there who are taking the money and presenting false hopes to patients that I certainly disagree with. And I have one particular patient I know who went to another country and had stem cell therapy done in what she described as a very dirty environment. And luckily nothing bad happened to her from this experience, but nothing good happened either. I’m hoping that she’ll be able to get into some of these well-done, scientifically valid, protocol-driven studies that seem to have some promise.    MSDF  Any other interesting areas of MS research in the past year?   Dr. Cross  I think the unexpected finding that I plan to talk about is an association of salt – sodium in particular, the sodium component of sodium chloride – in the development of a particular type of pathogenic T-cell that at least is related to the mouse model of MS called experimental autoimmune encephalomyelitis. These are Th17 cells and they’ve been shown to, at least in some models, cause the EAE model for MS. And it was found that if you increase the salt intake of mice that had been induced to develop this model and compared them to mice who weren’t getting extra salt in their diet, that the mice who got extra salt got disease earlier; they had a more severe course, they didn’t recover as well, and they had histologically when you looked at their central nervous systems, more cells infiltrating and just more damaging. So that was kind of interesting and quite unexpected, I would say.    Two different groups of investigators sort of came up with that at the same time; I’m sure they were speaking to each other about it, that the studies came out right together. It certainly would be a modifiable environmental thing if it proves to be true, and perhaps even a little bit simple. And there is actually a scientific reason behind why this might occur. Well, there’s a response in the body by something called p38 MAP kinase in response to, like, many different stresses, but including among them osmotic stress which increased salt could cause. And that pathway that p38 MAP kinase is involved in eventually can lead to the induction of a particular kinase that is key to the development of Th17 cells. So it sort of all, you know, fits together.    There are certainly some things that don’t fit with that. I think that certain areas of the world, for example, have very high salt intake and yet have low MS rates, but it may be that there’s this environmental factor. There probably are many different environmental factors that’s going together with a genetic predisposition, and those together are probably leading, perhaps, to MS. In any event, this will have to be proven by other groups, but if the association is true, it would certainly be modifiable.     MSDF  So looking ahead into the next year of MS research, what are you particularly looking forward to seeing?   Dr. Cross  I’d like to see more data come out on some of the other oral agents; there are a couple that are in the pipeline that are being looked at that perhaps have other mechanisms of actions from what we have now. I’d like to see other studies funded for estriol so that perhaps it could come to the United States and be an adjunctive therapy probably for women with MS and probably pretty safe. I’m really hopeful – I’m not sure if it’ll be in the next year – that we’ll see some good data coming out from these scientifically valid stem cells projects to help people with progressive MS, and help people who have longstanding disability to recover some function; those are the people that really, really need help in the MS world right now.   MSDF  Well, Dr. Cross, thank you very much.   Dr. Cross  Thank you.   [transition music]   Thank you for listening to Episode Five of Multiple Sclerosis Discovery. This Podcast was produced by the MS Discovery Forum, MSDF, the premier source of independent news and information on MS research. MSDF’s executive editor is Robert Finn. Msdiscovery.org is part of the nonprofit Accelerated Cure Project for Multiple Sclerosis. Robert McBurney is our President and CEO, and Hollie Schmidt is Vice President of Scientific Operations.    Msdiscovery.org aims to focus attention on what is known and not yet known about the causes of MS and related conditions, their pathological mechanisms, and potential ways to intervene. By communicating this information in a way that builds bridges among different disciplines, we hope to open new routes toward significant clinical advances.   We’re interested in your opinions. Please join the discussion on one of our online forums or send comments, criticisms, and suggestions to editor@msdiscovery.org.   [outro music]   

George Hamilton is the founder of Sentinel Productions which focuses on narrative film and is also the Creative Director at VCL a Production House based in Hoxton Square. Having directed commercials, music videos and narrative films he’s now scooping...

VCL 28 Thanks for joining us. Today Pastor Phil will bring our series Victorious Christian Living to a close, but not before he imparts a final exhortation to stand strong, and stand firmly on the Lord's side as you walk the road that lies yet ahead. Now lets look at Joshua chapters 23 and 24 as we join Pastor Phil.

VCL 27 Joshua Ch 17-22 As much as we might strive to walk faithfully with the Lord, there will always be those potential dangers that we would do well to avoid. Pastor Phil will draw our attention to Joshua chapters 17 through 22 as he seeks to identify some of these hazards. Let's listen as he brings us today's teaching.

VCL 26 Joshua 14:6-15 In examining what it takes to fight spiritual battles, it's helpful to be able to look at others who have experienced victory in such arenas. Does the Bible give us such examples? Indeed, and today Pastor Phil acquaints us with one such hero of the faith in his message Give Me This Mountain from Joshua chapter 14.

VCL 25 Joshua 13:1-14 Fighting battles in the Christian life is hard work. And frankly, sometimes it just seems easier to let up in a few areas just to try to find some rest. But truth be told, rest through compromise will bring you anything but what you were hoping for! Lets listen as pastor Phil speaks to this idea today in part one of his message Possessing the Fullness of God.

VCL 24 Joshua 9:14-27 While our adversary the devil has his schemes and devices to employ against Gods beloved, we too have a resource to lean upon. And as we'll learn today, if we don't take advantage of this resource, we will very likely fall. We turn now to Joshua chapter 9 as Pastor Phil brings us today's message, The Agony of Deceit.

VCL 23 Joshua 9:1-13 When we speak of spiritual warfare, we must understand that the devil does not simply fire his darts randomly, but rather he has devised various strategies to undermine the children of God. We would do well to learn them that we might experience victory against our adversary. Pastor Phil shares on this vital subject today, as we join him in Joshua chapter 9.

VCL 22 Joshua 8:30-35 Today we find ourselves in Joshua chapter 8. Looking at our text today, you'd get the sense that God's ways don't always line up with our ways. In the case of God's people, they had a momentum building as they gained victory in the promised land. But the God slowed them down-why? As we'll see, the Lord had good reason. Let's join Pastor Phil as he explains.

VCL 21 Joshua 8:1-29 There are many lessons that we can take away from the story of the Israelites tragic defeat at Ai, but one important insight that we want to make sure we consider is that of making regular healthy examinations of our hearts, in an effort to guard against sin. Pastor Phil brings this thought to the fore as we join him now in Joshua chapter 8.

VCL 20 Joshua 7:10-26 When sin gets into the camp, and it begins to bring defeat upon its shoulders, it can be humbling. But, it can also serve as a reminder of the need to be vigilant in our desire to protect the purity in our relationship with God. Joshua learned this hard lesson, and we'll look into these things as Pastor Phil brings today's teaching from Joshua chapter 7.

VCL 19 Joshua 7:1-9 On the road to victory in the Christian life, we must be careful to keep our path clear of sin. If we don't we're liable to learn the hard way that that sin may come back to trip us up. In Pastor Phil's study today, Joshua and the nation Israel discover what happens when sin abides in the camp. Let's join Pastor Phil in Joshua chapter 7.

VCL 18 Joshua 6:12-27 In the Christian life, our Promised Land, victory comes through obedience to God and His word. And consequently, as has been exampled often in history, victory is fleeting in the aftermath of disobedience. In part two of his study, Bringing Down Strongholds, Pastor Phil expands on this important truth.

VCL 17 Joshua 6:1-11 In the Christian life, our Promised Land, victory comes through obedience to God and His word. And consequently, as has been exampled often in history, victory is fleeting in the aftermath of disobedience. In part two of his study, Bringing Down Strongholds, Pastor Phil expands on this important truth. Let's join him now to hear more.

VCL 16 The time had come for God's people, the children of Israel to enter the Land of Promise. As Joshua prepared on that last evening before the entrance, he was met be a unique stranger. Who was it, and for what purpose did this meeting occur. It was a profoundly impacting encounter, and we'll learn about it today as we join Pastor Phil in Joshua chapter 5.

VCL 15 God desires that His people be holy, as they seek to live out the Christian life. While this seems like a heavy trip, God knows that the victory in the Christian life comes through holy living. Considering the sin in our lives and where we all came from, is holy living even possible? Pastor Phil speaks to this question today.

VCL 14 Moving into the Promised Land, God saw the need for this new generation of His people to be given a fresh start, a new beginning, and so He brought them to a place of re-consecration to Him. We will learn the importance of this in our own lives as well as we join Pastor Phil in Joshua chapters 4 and 5.

VCL 13 Having finally left the wilderness behind, and at long last entered the Promised Land, you'd think that it would be time to rest. But, really, many very important lessons on faith awaited God's people as they entered Canaan. We'll seek to glean as Pastor Phil shares on these Lessons at Gilgal, looking at Joshua chapter 4. Pastor Phil also shares about the power testimonies, living stones of God's faithfulness or Pastor Mike McIntosh and Pastor Raul Ries. God receives the glory for such profound changes in these now living stones.

VCL 12 Jesus never said that following Him would always be easy, but those who answer His call do discover a new kind of life, a life rooted in the purpose and plan of God. We're glad you've joined us for our study. Today Pastor Phil will turn our attention to Joshua chapter 4 as he brings us today's teaching.

VCL 11 Living a victorious Christian Life is rooted in total dependence upon God. In that walk of faith, we will often face obstacles in our path. What do you do when you find yourself in that place? We'll find out today as Pastor Phil shares his message from Joshua chapter 3, The Resurrection Life.

VCL 10 The Resurrection Life is a life lived in power and by faith. But the fact is that, just as the resurrection was proceeded by the crucifixion, so the resurrection life comes only after a certain kind of dying, as Pastor Phil will explain as he picks up our series Victorious Christian Living.

VCL Part 9 When we are born again in Christ, we leave the old life behind. Not simply in an effort to live up to a new set of rules, but so that we might enter into a new kind of life, a Resurrection Life. Over the next few studies, Pastor Phil will discuss and describe this powerful new life that we've been invited into. So let's join him now for today's teaching…

In some industries the key to success is summed up in three words, location, location, location. Interestingly, the same might be said when it comes to the Christian life. Pastor Phil explains as we open our Bible to Josua chapter 1 for a message entitled Where Are You Going To Live.