Podcasts about New Frontiers

Legacy Leadership: Why the Health of Women Executives Is the Next Frontier in Organizational PerformanceWhat happens when one of the strongest leaders in the room suddenly faces a health crisis she cannot immediately explain?In this powerful episode, we explore a personal experience from senior military leadership that reveals a critical yet overlooked dimension of executive performance: the health of women leaders.From chronic stress to immune reactions to the hidden physiological realities women navigate while leading high-stakes organizations, this episode reframes executive health as a strategic leadership asset.Listeners will discover how spiritual grounding, mental resilience, and conscious leadership practices can transform even the most frightening moments into catalysts for deeper purpose.This episode is for women leaders, executives, entrepreneurs, and anyone building a legacy that extends beyond titles and performance metrics.Because true leadership endurance begins with the health of the leader.Stay Connected with VivaLife SPF ME If this episode resonated with you, please like, share, and follow the VivaLife SPF ME Podcast on Spotify, Amazon, and Google Podcasts to help us spread the message of healing, empowerment, and intentional living.Subscribe to our YouTube Channelhttps://www.youtube.com/@vivalifespfmeJoin our communityGet access to our mailing list, upcoming events, and transformational experiences:https://www.vivalifespfme.com/dr-kelly-o-md-linktreeBook Dr. Kelly O., MD for your next event or speaking engagement:https://drkellyomd.com/book-for-an-eventPurchase your VivaLife SPF ME Journalhttps://vivalifespfme.com/vivalife-spfme-product-details/product/67ef31d160ab281de2e01b05Shop “We Can't Be Erased” MerchandiseT-shirts & hats that speak truth and strength:https://vivalifespfme.com/vivalife-spfme-product-details/product/67da338b44eafa3985031064/#Affirmation #365DaysofAffirmation #VivaLifeSPFMEPodcast #VivaLifeSPFME #VivaLifeHealthHUB #DrKellyOMD

In this episode of Disruption/Interruption, KJ sits down with Tracy MacNeal, CEO of Maternal Medical, to discuss a long-overlooked crisis in women's health: birth injuries. Tracy reveals how 10-15% of women who deliver vaginally experience severe pelvic floor trauma—injuries that often go undiagnosed and untreated for years. She shares how her company is developing groundbreaking technology to prevent these injuries during childbirth and why this space has been so dramatically underinvested. This conversation exposes the silence around maternal health and the urgent need for innovation in the delivery room. Four Key Takeaways: [11:28] The Hidden Epidemic of Birth Injuries - 10-15% of women who deliver vaginally suffer pelvic floor muscles torn off the bone—an injury only visible through ultrasound or MRI. This leads to pelvic organ prolapse, incontinence, and chronic pain, yet most women leave the hospital without knowing they've been injured. [5:22] Innovation Has Been Stalled for 80 Years - The epidural, introduced in the 1940s, was the last major innovation in labor and delivery. Unlike other medical fields that see constant advancement, maternal health has been dramatically underinvested, creating an anemic ecosystem for research and development. [20:12] Smart Technology That Listens to the Body - Maternal Medical's device gently pre-stretches the birth canal by listening to the mother's tissue and only expanding one millimeter at a time when the body relaxes. In clinical trials of over 200 patients, the device group had zero injuries compared to 11% in the control group. [30:58] The Power of Speaking Up - Women's silence about their symptoms has perpetuated the problem. When women speak up about birth injuries, it signals to investors that patients care and pushes physicians to prioritize these issues. Advocacy drives innovation and funding in healthcare. Quote of the Show (28:27):"Unless she's a fighter pilot, having a baby is the most dangerous thing most women will ever do."- Tracy MacNeal Join our Anti-PR newsletter where we’re keeping a watchful and clever eye on PR trends, PR fails, and interesting news in tech so you don't have to. You're welcome. Want PR that actually matters? Get 30 minutes of expert advice in a fast-paced, zero-nonsense session from Karla Jo Helms, a veteran Crisis PR and Anti-PR Strategist who knows how to tell your story in the best possible light and get the exposure you need to disrupt your industry. Click here to book your call: https://info.jotopr.com/free-anti-pr-eval Ways to connect with Tracy MacNeal: LinkedIn: https://www.linkedin.com/in/tracymacneal/Company Website: https://maternamed.com How to get more Disruption/Interruption: Amazon Music - https://music.amazon.com/podcasts/eccda84d-4d5b-4c52-ba54-7fd8af3cbe87/disruption-interruption Apple Podcast - https://podcasts.apple.com/us/podcast/disruption-interruption/id1581985755 Spotify - https://open.spotify.com/show/6yGSwcSp8J354awJkCmJlDSee omnystudio.com/listener for privacy information.

In this episode of New Frontiers in Functional Medicine, Dr. Kara Fitzgerald speaks with Dr. Robert Lustig about the new USDA dietary guidelines and the broader forces shaping nutrition and metabolic health. Dr. Lustig brings a characteristically direct and nuanced perspective on sugar, ultra-processed foods, and food policy—raising important questions about what drives real change. It's a thoughtful conversation that challenges assumptions and invites deeper reflection. Full show notes + references: https://www.drkarafitzgerald.com/fxmed-podcast/ GUEST DETAILS Robert H. Lustig, MD, MSL, is Emeritus Professor of Pediatric Endocrinology at UCSF and a neuroendocrinologist with expertise in obesity, metabolism, and nutrition. Known for his influential work on sugar and ultra-processed foods, Dr. Lustig focuses on improving metabolic health through food system reform, research, and advocacy. He is the author of Fat Chance, The Hacking of the American Mind, and Metabolical, and a leader with Eat REAL, Biolumen, SnapRecall, and Perfact. Website: https://robertlustig.com/ Email: rlustigmd@gmail.com THANKS TO OUR DIAMOND SPONSORS DUTCH: https://dutchtest.com/for-providers Biotics Research: https://www.bioticsresearch.com/ Time—Line Nutrition: https://tinyurl.com/bdzx2xms EXCLUSIVE OFFERS FROM OUR SPONSORS Find out why MitoQ's mitochondria-targeting is a critical step for your healthspan and longevity strategy. http://mitoq.com/drkara CONNECT with DrKF Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz YouTube: https://tinyurl.com/hjpc8daz Instagram: https://www.instagram.com/drkarafitzgerald/ Facebook: https://www.facebook.com/DrKaraFitzgerald/ DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb Younger You Practitioner Training Program: www.drkarafitzgerald.com/trainingyyi/ Younger You book: https://tinyurl.com/mr4d9tym Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw

What really happens inside the room where casting decisions are made? Casting director Paul Ruddy has spent nearly three decades shaping careers in film, television, and now the emerging world of vertical storytelling. In this revealing conversation, he explains how actors get cast, why self-tapes changed Hollywood forever, and how star power can be felt in the first 20 seconds of an audition. Paul shares behind-the-scenes stories about discovering talent early, including Sydney Sweeney's early auditions, the tiny acting choices that win roles, and why memorizing your lines still matters more than anything else. He also dives deep into: • The rise of verticals and micro-dramas • Why pilot season disappeared • The impact of streaming and the Hollywood strikes • Why in-person auditions are unlikely to return • How actors accidentally talk themselves out of roles • The truth about success, ego, and reputation in Hollywood If you're an actor, filmmaker, or simply curious about how Hollywood really works, this episode pulls back the curtain on the casting process and the industry's evolution. Subscribe for more insider conversations with the people shaping entertainment. 00:00 Intro: Inside the Room Where Careers Are Decided 01:02 Paul Ruddy's Origin Story: Scranton, TV Obsession, Law School 03:10 The Leap to Hollywood and the “Lied on My Resume” Move 05:21 The Power of Casting and Changing Lives 05:39 Early Talent Spotting and Sydney Sweeney's First Jobs 07:42 How Fast Casting Instincts Kick In 07:46 Paul's Best Advice: Do the Homework, Understand Tone 08:20 The #1 Audition Killer: Not Being Off Book 09:46 Can You Feel Star Power Right Away? 10:10 The Wetsuit Audition Disaster and Growth Over Time 12:39 Estelle Getty and Why Careers Can Start Later 13:20 Casting Directors Have Long Memories 14:05 When Someone Walks In and Wins the Role Instantly 16:20 What Are Verticals and Micro-Dramas? 16:35 TikTok Meets Soap Opera on Red Bull: The Vertical Model 18:40 How Episodes Work: 1–3 Minutes and Constant Cliffhangers 20:10 The Paywall Funnel and Why It's Exploding 21:20 Why Verticals Are a New Frontier for Hollywood 22:08 Patreon Break 22:57 How Casting Works: Breakdowns, Submissions, Narrowing Down 25:15 Will In-Person Auditions Ever Return? 25:25 Why Self-Tapes Took Over Permanently 27:49 The Reality of Nerves and “Pilot Season” Chaos 31:24 Self-Tapes vs Live Auditions and the 47th Take Problem 32:19 How the Pandemic Accelerated the Industry 10 Years 33:20 How Actors Talk Themselves Out of Roles 33:30 “You Sold It. Don't Buy It Back.” 38:58 Small Choices That Instantly Elevate an Actor 39:08 The Peephole Choice That Got Attention 40:15 The Orange Slice Prop That Won the Role 42:27 Break 42:43 Calling an Actor With Life-Changing News 44:11 Does Success Change an Actor's Energy? 44:30 Reputation Matters and Word Travels Fast 46:54 Watching Movies as a Casting Director 47:03 Why Every Role Must Be Cast at a High Level 48:49 Why He Didn't Become a Full-Time Producer or Director 50:00 Why Verticals Are an Incubator for Future Stars 52:10 “Nothing Is New” and Why People Always Dismiss New Formats 54:00 Verticals, Short Attention Spans, and the Real Competition 56:08 What He's Proudest Of After 27 Years 57:15 Advice for Actors: Tenacity and Knowing the Business 59:43 Is Hollywood Becoming a Dinosaur? Production Slowdown Explained 1:05:01 Fewer Risks, Fewer Sitcom Hits, and Why Shows Need Time 1:07:13 The Loss of Shared TV Culture and Knowing What Came Before 1:09:20 Closing and Thanks Show Credits Host/Producer: Steve Kmetko All things technical: Justin Zangerle Executive Producer: Jim Lichtenstein Music by: Brian Sanyshyn Transcription:  Mushtaq Hussain   https://stillherehollywood.com http://patreon.com/stillherehollywood Suggest Guests at: stillherehollywood@gmail.com Advertise on Still Here Hollywood: jim@stillherenetwork.com Publicist: Maggie Perlich: maggie@numbertwelvemarketing.com   Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

This podcast is made possible by our listeners and viewers. If this show has brought you value, you can support it by becoming a member of The Way Forward, our platform designed to help you find the health and freedom community (people, practitioners, schools, farms, and more) near you. Your membership directly supports the podcast and the work we do.Our bodies don't work like we think they do…Carlos Millán, a biologist and a mystic, questions some of the most foundational assumptions in modern biology. He proposes a framework that connects water, electricity, and consciousness, challenging the way the human body is typically understood. If the dominant model is incomplete, the implications extend far beyond the lab.We explore the world of consciousness through the lens of biology. We also revisit a nearly forgotten medical therapy that once treated severe infections by altering only a small portion of the blood. The results were documented, yet the explanation never fully aligned with the prevailing scientific model.At the center is a different way of seeing the body as an energetic ecosystem rather than a mechanical structure, and what that shift could mean for health, education, and the future of science.You'll Learn:[00:00] Introduction[08:05] The 100-year-old treatment that structured blood, not killed bacteria[18:57] What a dissolving mollusk egg reveals about blood, consciousness, and the placebo effect[33:29] A terminal cancer patient's 50% tumor reduction in one week[46:23] What your immune system is doing instead of killing bacteria[59:37]  How the body sustains itself without food, and the kidney's real role in that[01:07:09] How fluorescent light collapses a cell's electromagnetic field within seconds[01:34:59]  How lidocaine resets trauma stored in nervous tissue [01:43:31] When physical pain is a message, not a malfunction[01:58:55] Why nerves are conscious decision-makers, not passive wiresRelated The Way Forward Episodes: Quinton Marine Plasma with Robert Slovak | PodcastEp 172: The 4th Phase of Water: The Blueprint for Biological Energy with Dr. Gerald Pollack | PodcastResources Mentioned:Ultraviolet blood irradiation: Is it time to remember “the cure that time forgot”? By Ximing Wu et al. | ArticleFind more from Carlos:Carlos | WebsiteFind more from Alec:Alec Zeck | InstagramAlec Zeck | XThe Way Forward | InstagramThe Way Forward is Sponsored By:RMDY Academy & Collective: Homeopathy Made AccessibleHigh-quality remedies and training to support natural healing.Enroll hereExplore hereDr. Cowan's Garden helps you boost daily nutrient density with vegetable powders and clean, pasture-raised essentials. Shop now and use code: THEWAYFORWARD for 15% off your first order.

Nat Eliason joins to show what it looks like to build a “zero human company” with OpenClaw agents. — led by Felix, an AI CEO that ships products, runs ops, and even manages other agents for support and sales.  We unpack how Felix went from an overnight info product to a full marketplace for agent “skills” (Clawmart) and a bespoke service that deploys custom OpenClaw employees for real businesses, hitting nearly $80k in revenue since early February while operating on surprisingly low monthly costs. ------

Customer greases a palm for a perk, but what happens when the shoe is on the other foot? Steve welcomes Clarice Tinsley, Shannon Murray and from 102.9FM DJ Billy The Kidd to the panel.

In this episode: The consolidation of Muslim control of North Africa; The illuminating legacies of Qayrawan, Tunis and Fez, and the role of the Maghrib region in even greater expansion for Islam, and the shaping of defining moments for the Ummah.

Property restoration is gaining in complexity. Advancements in technology have led to an evolution in process but also customer expectations. Meanwhile, new building materials, a dynamic regulatory environment and the growing severity of CAT events, have made it difficult for property restorations teams to keep up. In this video perspective interview, you'll hear from PropertyCasualty360's editor-in-chief Elana Ashanti Jefferson first lay out how the restoration business has changed, and then learn from 1-800 WATER DAMAGE's franchise owner Jason Phillips and regional business coach John Otero on what they're doing to ensure they are employing the latest in technology and customer service. You'll learn: ●     What the four key challenges are for property restoration; ●     Why training and resources are key to adapting to the new, evolving normal; and ●     Which innovations are allowing 1-800 WATER DAMAGE and their franchisees to finish a restoration swiftly and keep their lead in customer satisfaction. For more insights from the 1-800 Water Damage team of experts, click here.

Host Pallav Mehta, MD, and guest Doug Flora, MD discuss the use of artificial intelligence (AI) in oncology. As the author of Rebooting Cancer Care, Flora argues that AI is the essential "reboot" needed for a system currently "groaning under its own weight" due to physician burnout and an unmanageable explosion of medical data.

In Priests, guest speaker Raj Saha of Jubilee Church Teesside looks at Isaiah 61. Raj tells us that priesthood isn’t just for “ministers”—it’s for all of us. Raj explores how Jesus tore the temple curtain to create a “multicoloured priesthood” of all believers, uniquely positioned to lead a “quiet revival” in our communities today. From his upbringing in a Hindu family to his work as a GP, Raj shares personal stories of how God uses our diverse backgrounds to showcase His glory.The post Raj Saha – Priests first appeared on Jubilee Church Wirral.

In Business Matters this week Chris Ashmore finds out about an event being held as part of Enterprise Week that ties in with International Women’s Day, and he also finds out about the next New Frontiers programme at ATU Letterkenny, which is geared towards people with innovative business ideas that have the potential to scale […] The post Business Matters, Ep 285: International Women’s Day event in Donegal – plus the New Frontiers programme appeared first on Highland Radio - Latest Donegal News and Sport.

The following article of the Health industry is: “Why Gut Health Is the New Frontier in Precision Wellness” by Gustavo Rodríguez Leal, Founder and CEO, NutriADN.

The First Amendment protects America from our government’s suppression of speech. Who will protect that speech from other governments? Facebook Twitter LinkedIn Reddit Messenger Email SourceThe post “Censorship by Foreigners: The New Frontier in Free Speech” appeared first on The ColemanNation Podcast.

In this episode of Private Markets 360°, we welcome Sarah Samuels, Chief Investment Officer at NEPC. With a diverse background in managing endowments, family offices, and public pensions, Sarah discusses the dynamic nature of capital raising, the importance of due diligence, and innovation. She highlights opportunities in the lower middle market, the convergence of public and private markets, and the impact of economic disruption on investment strategies. Drawing on her experience as Chair of the CFA Society Boston, Sarah shares her passion for education and financial literacy, which inspired her to author a children's book on money and role models.   More S&P Global Content:  [Report] Private Equity Outlook 2026 Credits:  Host/Author: Chris Sparenberg and Jocelyn Lewis Guests: Sarah Samuels, NEPC Producer: Georgina Lee Published With Assistance From: Feranmi Adeoshun, Kimberly Olvany www.spglobal.com www.spglobal.com/market-intelligence

New Frontier Minerals Senior Consultant Kevin Das joined Steve Darling from Proactive's OTC studio in New York City to provide an update on the company's growing copper and heavy rare earth strategy, highlighting expanding exposure to the U.S. critical minerals market. Das explained that New Frontier Minerals, listed on the Australian Stock Exchange, London Stock Exchange, and recently on the OTCQB, is focused on a dual approach: advancing copper projects in northwest Queensland while also developing heavy rare earth assets. In Queensland, the company is progressing a copper project that already hosts a mineral resource of 2.1 million tonnes at 1.1% copper, representing just under 22,000 tonnes of contained copper metal. Das highlighted a recently announced broader exploration target for the Northwest Queensland Copper Project, ranging from 12 million to 57 million tonnes at grades of 0.3% to 1.5% copper, supported by 14 prospective targets across the project area. Drilling plans and budgets are under review to expand and underpin the existing resource at the Big One Deposit. In addition to copper, New Frontier is advancing heavy rare earth exploration, having secured an option on a carbonatite rare earth property in Quebec. Das emphasized the company's strategic rationale for listing on the OTCQB, noting strong U.S. demand for critical minerals and positioning New Frontier to provide the right commodities to meet that need. Management believes the combined copper and rare earth strategy, coupled with expanded U.S. market access, enhances the company's global critical minerals footprint and supports long-term growth in both supply and investor visibility. #proactiveinvestors #newfrontierminerals #asx #nfm #otcqb #nfmxf #CriticalMinerals #CopperExploration #RareEarths #ASX #OTCQB #MiningStocks #NorthwestQueensland #CopperProject #ResourceDevelopment #USMarkets #EnergyTransition #MineralExploration

Send a textWhy are so many people dealing with chronic pain earlier than ever?In this episode, Dr. Kevin White sits down with Dr. Ashu Goyle, a double board-certified anesthesiology and pain medicine physician trained at the Cleveland Clinic and founder of Integrated Spine, Pain, and Wellness in Scottsdale, Arizona.Dr. Goyle shares how his philosophy shifted from simply interrupting pain signals to helping the body repair itself. They unpack why back pain, knee pain, and joint degeneration are rarely isolated problems, and why treating one body part without addressing sleep, nutrition, inflammation, stress, and biomechanics often leads to temporary relief instead of lasting change.They discuss regenerative approaches like PRP and other orthobiologic therapies, metabolic optimization before procedures, laser therapy, nervous system balance, and what it really takes to create an environment where healing can occur.“If you're going to put something powerful back into your body, make sure the environment you're putting it into is ready.”This conversation challenges the quick-fix mindset and reframes pain as part of a bigger story. If you want to stay strong, active, and capable as you age, this episode will change how you think about healing.Learn more about Dr. Ashu Goyle:Or find him on Instagram @DrAshuGoyleFollow The Daily Apple and leave a review to help more people find the show.www.primehealthassociates.com Instagram: @KevinWhiteMD YouTube: @KevinWhiteMD Prime Health Associates

We push past rankings and traffic to map the real skills SEOs need to influence AI answers. Duane Forrester explains the machine layer, vector embeddings, semantic density, and why structured data is a must if you want reliable retrieval.• AI reshapes marketing and elevates SEO's role across the business• Good SEO foundations as the prerequisite for AI performance• Writing for chunks with high semantic density• Structured data and entity clarity to validate facts• Vector embeddings as the new alignment target• KPIs beyond rankings: retrieval confidence and zero‑click presence• Why LLMs.txt lacks adoption and what matters instead• Practical tracking of AI answers and trend analysis• The gap between search engines and LLM information retrieval• Learning paths to keep pace with faster platform updatesGuest Contact Information: Website: duaneforrester.comLinkedIn: linkedin.com/in/dforresterTwitter/X: x.com/DuaneForresterMore from EWR and Matthew:Leave us a review wherever you listen: Spotify, Apple Podcasts, or Amazon PodcastFree SEO Consultation: ewrdigital.com/discovery-callWith over 5 million downloads, The Best SEO Podcast has been the go-to show for digital marketers, business owners, and entrepreneurs wanting real-world strategies to grow online. Now, host Matthew Bertram — creator of the LLM Visibility Stack™, and Lead Strategist at EWR Digital — takes the conversation beyond traditional SEO into the AI era of discoverability. Each week, Matthew dives into the tactics, frameworks, and insights that matter most in a world where search engines, large language models, and answer engines are reshaping how people find, trust, and choose businesses. From SEO and AI-driven marketing to executive-level growth strategy, you'll hear expert interviews, deep-dive discussions, and actionable strategies to help you stay ahead of the curve. Find more episodes here: youtube.com/@BestSEOPodcastbestseopodcast.combestseopodcast.buzzsprout.comFollow us on:Facebook: @bestseopodcastInstagram: @thebestseopodcastTiktok: @bestseopodcastLinkedIn: @bestseopodcastConnect With Matthew Bertram: Website: www.matthewbertram.comInstagram: @matt_bertram_liveLinkedIn: @mattbertramlivePowered by: ewrdigital.comSupport the show

New reporting frameworks and regulations around stablecoins are coming thick and fast; in this episode, two experts from the AICPA, Di Krupica and Jeff Trent, discuss the new rules and what they mean for accountants and their clients.

Sarah Poland, MD, lead author of a recently published article in the journal ONCOLOGY titled Advances in Immunotherapy for Breast Cancer, highlighted key findings from her review in a conversation with CancerNetwork®.1 Throughout the discussion, she spoke about: Shifting Perspectives on Immunogenicity: Historically, breast cancer was considered a “cold,” poorly immunogenic tumor due to low tumor mutational burden (TMB) and few tumor-infiltrating lymphocytes (TILs). Poland highlighted how clinical research has shifted this perspective, particularly through the study of triple-negative breast cancer (TNBC), which often exhibits higher PD-L1 expression and immune infiltration.Key Clinical Milestones: The review highlighted foundational data that established immunotherapy as a standard of care: Early-Stage TNBC: The phase 3 KEYNOTE-522 trial (NCT03036488) established pembrolizumab (Keytruda) plus chemotherapy as a standard neoadjuvant treatment for stage II to III TNBC.2 Metastatic TNBC: The phase 3 KEYNOTE-355 trial (NCT02819518) demonstrated the benefit of pembrolizumab in PD-L1–positive metastatic disease.3 Managing Toxicity and Rechallenge: Poland addressed the feasibility of pembrolizumab rechallenge after an immune-related adverse effect (irAE), emphasizing that while possible, it requires a highly individualized approach based on the severity and timing of the initial toxicity.The Future Landscape: Beyond PD-1/PD-L1 inhibitors, the discussion covered emerging technologies that are poised to redefine treatment: Antibody-Drug Conjugates (ADCs): Exploration of novel combinations of ADCs with immunotherapy. Emerging Modalities: The potential role of bispecific antibodies and vaccine trials utilizing tumor antigens. Subtype Expansion: Emerging evidence supporting the efficacy of immunotherapy in hormone receptor–positive and HER2-positive subtypes, moving beyond the traditional focus on TNBC. Unmet Educational Needs: Poland emphasized the importance of resources that connect providers and patients, particularly in translating complex trial data into clinical practice and addressing patient concerns regarding the newest therapies and trials.Poland is from the Department of Medicine in the Section of Hematology/Oncology at The University of Chicago.References1.        Poland S, de Oliveira Andrade M, Nanda R. Advances in immunotherapy for breast cancer. Oncology (Williston Park). 2026;40(1):8-15. doi:10.46883/2026.259210612.        Schmid P, Cortes J, Pusztai L, et al. Pembrolizumab for early triple-negative breast cancer. N Engl J Med. 2020;382(9):810-821. doi:10.1056/NEJMoa19105493.        Cortes J, Rugo HS, Cescon DW, et al. Pembrolizumab plus chemotherapy in advanced triple-negative breast cancer. N Engl J Med. 2022;387(3):217-226. doi:10.1056/NEJMoa2202809

Join Our Patreon: http://patreon.com/vvclifeGrab Some Gear: http://vvcmerch.comGeneral TalkWeekly Recap Sign Up For PatreonBaldur's Gate 3 Session 20 at 8pm!Monday Night Co Op “Green Hell!!The Precious: JS-1: https://amzn.to/46j8xpPFame: https://a.co/d/03XYio1gJaelyn: https://a.co/d/0eztCO4tSloan: https://a.co/d/06UaMi5mCommercial #1Main Topic: Key Discussion PointsRiddle Me this: Commercial: #2Games:Don't Panic, It's Just TurbulanceThe Eternal Life Of GoldmanYakuza Kiwami 3Pax AutocraticaCroakNews: Xbox CEO leaving with a friend?Takedra Brings In Billions For WaymoSuper Hero Trading CardsHow To Unredact The Epstein FilesThe Entire Financial System is flippingLife is a video gameA.I./ robot Segment:Military Robots are hereDance robots are hereOthersBiggest robot developersComic Of The week: GagoInstagram:  http://instagram.com/blacknerdpodcast  facebook:   http://facebook.com/blacknerdpodcastReddit: https://www.reddit.com/r/blacknerdgang/s/uftLsO0Ad9website: http://blacknerdpodcast.comhttp://twitter.com/vvcradio   http://instagram.com/js1thasupplier  http://instagram.com/fameplanbhttp://instagram.com/jaelynaleisehttp://instagram.com/sloan_tempest

Does your confidence depend on your performance? Whether it's in sports, at work, or in our everyday relationships, we all know what it feels like to lose our confidence. Setbacks, stress, and unexpected news can make us want to withdraw and give up. But in this message, Dave explores Hebrews 10 to show us a type of confidence that isn't based on what we do, but on what has already been done for us. Dave looks at: The Source of True Confidence: Why the “therefore” in Hebrews 10:19 changes everything. The Barrier Removed: What the “four-inch thick curtain” meant for the Old Covenant and why it was torn in two. The “How Much More” Factor: Comparing the temporary sacrifices of the past to the eternal redemption found in Jesus. The Power of Community: Why we need each other to stay “on fire” and keep from drifting away. If you've been feeling like you aren't “holy enough” to approach God, or if life has knocked your confidence lately, this message is for you.The post Dave Frodsham: Our confidence is in Christ first appeared on Jubilee Church Wirral.

Innovations in eye care are changing how we treat dry eyes and enhance facial aesthetics. Dr. Harbir Sian explores these advances with Dr. Vicente Rodriguez, Global Medical Director of Jett Plasma, who explains how this revolutionary technology uses low-intensity electrical stimulation to target the conjunctiva, eyelid margin, accessory glands, and orbicularis muscles. He shares the evolution of Jett Plasma from non-invasive facial rejuvenation to advanced ocular applications, detailing techniques for treating blepharitis, Meibomian gland dysfunction, and lid wiper epitheliopathy, while also highlighting emerging possibilities for retinal stimulation and veterinary applications. This conversation offers a rare, in-depth look at how precise electrical stimulation is improving patient outcomes and expanding the frontiers of ophthalmology and optometry.Connect with Harbir:InstagramLinkedInYouTubeLove the show? Subscribe, rate, review & share! http://www.aboutmyeyes.com/podcast/

In this eye-opening episode of Rising Anxieties, Mariann Sullivan exposes the dairy and animal agriculture industry’s latest manipulation tactics with her signature wit and clarity. From the misleading rhetoric attempting to justify livestock mistreatment, to the dairy industry’s aggressive push to get whole milk back into schools, to the disturbing “Beef on Dairy Revolution” that commodifies cows’ reproductive systems, this episode…

In this episode of the Flagship Podcast, we sit down with Tyler Reid, co-founder and CEO of Zona Space, to explore the future of satellite navigation and why GPS as we know it is no longer enough. Tyler shares his journey from space-obsessed kid to Stanford researcher to venture-backed space founder, and explains how Zona is building a next-generation positioning system designed for centimeter-level accuracy, stronger signals, and built-in security. We unpack how modern infrastructure depends on timing and location, why GPS is vulnerable to jamming and spoofing, and what new satellite constellations unlock for autonomous systems, defense, data centers, and everyday devices. We also go deep on building a hard-tech startup: raising capital for space infrastructure, launching satellites, assembling the right team, and navigating the long road from research to orbit. If you're interested in space tech, deep tech startups, autonomous systems, or the new space economy, this episode is for you. Topics covered: Why GPS needs an upgrade How next-gen satellite navigation works Centimeter-level positioning and resilient timing Space infrastructure and low-Earth orbit constellations From PhD research to space startup Lessons from building a hardware + space company The coming wave of space innovation and lunar missions

The continued release of the Epstein files has sparked difficult but necessary conversations across the medical, longevity, and wellness communities. In this candid and deeply reflective episode of New Frontiers in Functional Medicine, Dr. Kara Fitzgerald sits down with Dr. Sara Szal and Dr. Brad Jacobs to explore what this moment calls forward from clinicians — ethically, professionally, and personally. Together, they discuss: • Medical accountability and the responsibility that comes with influence • The ethical obligations of physicians and mandated reporters • How the medical system has failed vulnerable adolescents — especially young women • Power dynamics, patriarchy, and the culture of silence • Trauma, ACE scores, and measurable impacts on long-term health • What practitioners can do differently starting now This is a thoughtful, clinician-focused conversation about integrity, trauma-informed care, and the role healthcare providers play in protecting and supporting patients. If you care about the future of ethical, patient-centered medicine, this is an important listen. Full show notes + references: https://www.drkarafitzgerald.com/fxmed-podcast/ GUEST DETAILS Dr. Sara Szal is a best-selling author, board-certified gynecologist, and women's health expert focused on helping women navigate perimenopause and menopause with strength and clarity. Her work integrates evidence-based medicine, advanced lab testing, and targeted lifestyle protocols to support body composition, metabolic health, sleep, mood, and cognitive vitality. Website: https://saraszalmd.com/ Dr. Bradley Jacobs is a Stanford-trained physician and outcomes researcher specializing in men's health, longevity, and behavior change. His work blends precision medicine, psycho-emotional development, and performance optimization to help men build vitality, resilience, and sustainable healthspan. Website: https://www.bluewavemedicine.com THANKS TO OUR DIAMOND SPONSORS DUTCH: https://dutchtest.com/for-providers Biotics Research: https://www.bioticsresearch.com/ Time—Line Nutrition: https://tinyurl.com/bdzx2xms EXCLUSIVE OFFERS FOR OUR LISTENERS Find out why MitoQ's mitochondria-targeting is a critical step for your healthspan and longevity strategy. https://tinyurl.com/4f8t7jt6 *CONNECT with DrKF* Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz YouTube: https://tinyurl.com/hjpc8daz Instagram: https://www.instagram.com/drkarafitzgerald/ Facebook: https://www.facebook.com/DrKaraFitzgerald/ DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb Younger You Practitioner Training Program: www.drkarafitzgerald.com/trainingyyi/ Younger You book: https://tinyurl.com/mr4d9tym Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw

Early evidence for CAR T-cell therapy in lupus is compelling. Are you up-to-date? Credit available for this activity expires: 2/9/26 Earn Credit / Learning Objectives & Disclosures: https://www.medscape.org/viewarticle/car-t-cells-sle-new-frontier-autoimmunity-2026a10003ow?ecd=bdc_podcast_libsyn_mscpedu

The New Frontier of Hospitality: Optimizing for AI and Direct Bookings with Adam HamadacheIn this episode of The Thoughtful Entrepreneur Podcast, host Josh Elledge sits down with Adam Hamadache, the CEO of Formula Digital, to discuss the radical evolution of how travelers find and book accommodations. As AI-powered search tools like ChatGPT and Perplexity begin to act as digital concierges, traditional SEO is no longer enough for independent hotels to remain competitive. Adam shares his expertise on how hospitality brands can bridge the gap between classic search engine visibility and the emerging world of AI optimization, ensuring they capture guest attention and drive high-value direct bookings in an increasingly automated marketplace.Mastering the Shift from Search Engines to AI EnginesThe traditional playbook for hospitality marketing is being rewritten as AI platforms move from simple chatbots to fully integrated booking interfaces. Adam explains that the modern definition of SEO has expanded to include "AI Visibility," which requires a website to be easily "readable" by large language models that suggest travel itineraries and specific properties to users. For independent hotels, this means the technical health of a website—specifically the implementation of structured data and schema markup—is now just as important as the aesthetic design. If an AI tool cannot instantly identify a hotel's amenities, pricing, and location through its backend code, that property essentially ceases to exist in the eyes of the digital concierge.Beyond the technical hurdles, Adam emphasizes that the human element of reputation remains a primary data point for AI recommendations. These intelligent systems don't just look for keywords; they synthesize guest reviews, consistent business information, and topical authority to determine which hotels are "trustworthy" enough to recommend. Maintaining absolute consistency across directories and actively managing online reviews are no longer just administrative tasks—they are the fuel that powers an AI's decision to put a property in front of a potential traveler. By treating online reputation as a core SEO asset, hotels can significantly lower their reliance on expensive third-party booking platforms and recapture their profit margins.To help hospitality leaders navigate these changes, Adam highlights the importance of creating "content hubs" that establish a property as a local authority. Instead of thin, disconnected blog posts, hotels should focus on interlinked, comprehensive guides that answer every possible question a traveler might have, from wedding logistics to local hidden gems. This depth of information signals to both Google and AI bots that the brand is an expert in its niche, resulting in higher rankings and more personalized user experiences. As the hospitality industry moves toward hyper-personalization, those who invest in these foundational digital strategies will be best positioned to thrive in the era of AI-driven travel.About Adam HamadacheAdam Hamadache is the CEO and founder of Formula Digital, a specialized agency dedicated to driving digital growth for independent hotels. With a deep background in hospitality marketing and technology, Adam is a recognized expert in helping hotel brands increase direct bookings and optimize their online presence for the next generation of search.About Formula DigitalFormula Digital is a hospitality-focused digital agency that helps independent hotels compete with major chains by leveraging advanced SEO, AI optimization, and direct booking strategies. The agency also developed Score Plan AI, a proprietary tool that allows hotel owners to benchmark their visibility across AI platforms and search...

This month, Darrin is NOT a fan of a Tarantino-esque miniseries, Chad has some questions about the Fantastic Four, Justin takes a look back at DC's The New Frontier, and Darrin's cats get into trouble.  Download and listen today on Apple Podcasts, Spotify, iHeart, Amazon, Stitcher, Goodpods, and more of your favorite podcast services!  Interested in advertising? Want to be on the show? Reach out at geekcavepodcast@gmail.com

Dominic Jacobson, Senior Equity Analyst in EFG Asset Management's US Growth Equity team unpacks whether tech bubble fears are misplaced, and why compute power and energy availability may in fact be keeping excess in check. Also featured are geopolitical competition, open-source versus closed-source models and what could be the next big untapped opportunity in tech.Our host, Moz Afzal:https://bit.ly/31XbkTROur guest:Dominic Jacobsonhttps://bit.ly/4taOiV2EFGAM:https://www.newcapital.com/Important disclaimersThe value of investments and the income derived from them can fall as well as rise, and past performance is no indicator of future performance. 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Kilian Korth is a pro trail runner and coach most known for his recent dominance of the 200-mile distance. In 2025, Kilian won the Tahoe 200, Bigfoot 200, and the Moab 240 in a four month span, shattering the cumulative record for the Triple Crown of 200s by more than five hours. He's become viewed as a leader and pioneer in the discipline, rigorously documenting and sharing his learnings from this still nascent competitive sub-category of the sport. This is his first appearance on the podcast.   Subscribe to Kilian's substack     Chapters: 02:35 – Introduction and Early Life 05:30 – The Journey into Ultra Running 08:15 – The Rise of 200-Mile Races 11:16 – Philosophy and Mindset in Ultra Running 14:14 – Training for 200-Milers 17:16 – Strength Training and Its Importance 20:06 – The Role of Intensity in Training 22:55 – Overcoming Challenges and DNF Experiences 25:49 – Self-Reflection and Personal Growth 28:37 – Looking Ahead to Future Races 41:34 – Speed Work: The High-Risk Investment 42:31 – Emerging Training Strategies for 200-Mile Races 44:41 – Family Bonds: Running with My Dad 47:29 – Aiming for the Triple Crown: Goals and Aspirations 48:13 – Lessons from the Tahoe 200: Embracing Slog Miles 49:12 – Bigfoot 200: Fun in the Grind 51:15 – Moab 240: The Importance of Support 52:40 – Breaking Records: Reflections on the Triple Crown 56:15 – Race Strategy: Move Slow, Never Stop 01:00:05 – Recognition in the Ultra Community 01:06:35 – Sponsorships and Building a Brand 01:10:00 – Future Goals: Coca-Dona and Beyond   REGISTER FOR THE BIG ALTA   REGISTER FOR GORGE WATERFALLS   Sponsors:   Grab a trail running pack from Osprey Use code FREETRAIL25 for 25% off your first order of NEVERSECOND nutrition at never2.com Go to ketone.com/freetrail30 for 30% off a subscription of Ketone IQ   Freetrail Links: Website | Freetrail Pro | Patreon | Instagram | YouTube | Freetrail Experts   Dylan Links: Instagram | Twitter | LinkedIn | Strava

Good morning from Pharma Daily: the podcast that brings you the most important developments in the pharmaceutical and biotech world. Today, we'll delve into the multitude of changes and advancements sweeping across the industry, each with profound implications for drug development, patient care, and market dynamics.The pharmaceutical landscape continues to transform as companies like Daiichi Sankyo make significant progress with antibody-drug conjugates (ADCs). Their collaboration with AstraZeneca on products like Enhertu and Datroway represents a robust push into earlier lines of therapy. This strategic move aligns with a broader industry trend where ADCs are being positioned as front-line oncology treatments. These therapies are lauded for their targeted delivery mechanisms that maximize therapeutic efficacy while minimizing off-target effects. However, the competitive landscape is becoming increasingly fierce, necessitating robust clinical data to stand out in this rapidly evolving market segment.Elsewhere, Moderna's recent decision to pause new late-stage trials for infectious disease vaccines highlights the intricate interplay between public sentiment and corporate strategy. The rising anti-vaccine sentiment in the U.S., compounded by diminishing support infrastructure from previous administrations, has significantly influenced Moderna's strategic recalibration. This situation underscores a critical challenge for developers of mRNA platforms: how to navigate complex public perceptions and policy landscapes while pushing forward with vaccine innovations.From a regulatory perspective, Recipharm's commissioning of a new facility in Bengaluru, India for non-bacterial beta-lactam drugs aligns with evolving FDA standards. This investment is not just about compliance; it's a proactive adaptation to meet rising customer demand and represents a strategic partnership with a major biopharmaceutical player. Such collaborations are crucial as they help scale drug production capabilities effectively.The dissolution of the marketing partnership between Arcutis and Kowa over Zoryve reflects the ever-dynamic nature of commercial collaborations within the industry. Originally intended to broaden Zoryve's market beyond dermatologists to include primary care physicians, this shift may indicate strategic realignments or divergent priorities between partners. Such changes can significantly impact market penetration strategies and highlight the importance of aligned goals within partnerships.In Europe, regulatory expansion by GSK of its Arexvy vaccine for all adults marks a pivotal milestone in widening access to crucial vaccines. This development not only enhances GSK's market presence but also underscores the agility required in regulatory responses to public health needs.On the financial front, settlements under the False Claims Act reaching $6.8 billion in FY2025 demonstrate heightened scrutiny on compliance practices within the industry. This serves as a stark reminder of both financial and reputational risks tied to non-compliance and underscores an ongoing need for stringent oversight mechanisms.Amidst economic uncertainties, AstraZeneca's decision to pause its UK research site investment reflects broader industry challenges related to strategic reallocations of resources. Companies are increasingly re-evaluating their geographic footprints and investment priorities in response to evolving market conditions.In precision oncology, Guardant Health's FDA approval for its Guardant360 CDx test in conjunction with Pfizer's Braftovi highlights how companion diagnostics are becoming integral in enhancing therapeutic outcomes through tailoring treatments based on specific genetic profiles. These developments illustrate a multifaceted landscape where scientific innovation, regulatory changes, strategic partnerships, and compliance considerations converge.The recent landscapSupport the show

This is just my opinionIntro song is ‘⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Bring Me Down⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠'⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Buy Me a Coffee⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠The Slippery Slope Spotify⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠J Fallon Spotify⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠The Slippery Slope Apple Podcasts⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠The Slippery Slope YouTube⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Secrets to self-preservation in an age of burnout.   Tim Ferris is the author of five #1 New York Times bestsellers, including The 4-Hour Workweek and Tools of Titans. He's also the host of The Tim Ferriss Show podcast. Most recently, he has collaborated with Exploding Kittens to create COYOTE, a fast and hilarious card game.  In this episode we talk about: Tim's Antidotes to isolation Past-year reviews The perils of self-optimization His meditation practice Escaping rumitive loops  The role of Accelerated Transcranial Magnetic Stimulation (TMS) The ketogenic diet  Talking to chatbots about your health And much more Get the 10% with Dan Harris app here Sign up for Dan's free newsletter here Follow Dan on social: Instagram, TikTok Subscribe to our YouTube Channel Additional Resources:  The New Frontiers of Mental Health — Brain Stimulation, Rapid-Acting Tools for Depression, and More All Things Ketones, How to Boost Cognition, Sardine Fasting, Diet Rules, & More — Dr. Dom D'Agostino TED: Why you should define your fears instead of your goals Tim Ferriss, Host of 'The Tim Ferriss Show,' Author   To advertise on the show, contact sales@advertisecast.com or visit https://advertising.libsyn.com/10HappierwithDanHarris       Thanks to our sponsors:  LinkedIn:  Spend $250 on your first campaign on LinkedIn ads and get a $250 credit for the next one. Just go to linkedin.com/happier. HexClad:  Get 10% off your order with our exclusive link. Just head to hexclad.com/happier. Square:  Right now, you can get up to $200 off Square hardware at square.com/go/happier.

From cell-cultured protein and functional soda to premium cereal and frozen snacks, this episode spotlights innovative brands, emerging partnerships, and winning strategies gaining momentum across the CPG landscape. Show notes: 0:25: Control, This Is BTS. Faire Plays & Pops. A Magnificent Merger. Magic Mallows? Hey, Maker. – Ray and Mike kick things off by unpacking a chaotic behind-the-scenes studio setup before spotlighting standout brands from the 2026 Winter FancyFaire*, including a globally inspired popcorn line, a kid-friendly rooibos tea–based hot cocoa, vegan and gluten-free frozen churros, and Quatro Mamas' salsa macha. The hosts also review Culture Pop's limited-edition black cherry soda collaboration with musician Noah Kahan and discuss the merger of three female-led CPG brands as a savvy early-stage strategy to streamline costs and scale more efficiently. Rounding things out, they dig into Magic Spoon's new protein cereals with marshmallows and protein pastries, along with Tractor Beverage's apple cider vinegar–based "Haymaker" ready-to-drink tonics. 19:58: Interview: Lou Cooperhouse, Co-Founder & CEO, BlueNalu – Lou discusses how BlueNalu is pioneering cell-cultivated seafood, the science behind the breakthrough, and why it could be a new frontier for sustainable, chef-driven dining. 28:11: Interview: Heather Brown, Owner, Sati Soda – Heather shares how Sati Soda has grown into a nationwide brand, offering organic CBD, functional, and low-sugar beverages that resonate with health-conscious consumers. Brands in this episode: BlueNalu, Sati Soda, Nomad Snacks, Teany Tea, Madres Churros, Culture Pop, Nemi, Tuyyo, Todo Verde, Magic Spoon, Cheerios, Pop-Tarts, Tractor Beverage Co., Olipop, Poppi, Miller, Quatro Mamas

AI Ads: A New Frontier for Nonprofits This week on the Nonprofit Newsfeed the hosts dive into a game-changing announcement from OpenAI that could revolutionize nonprofit marketing strategies. OpenAI has revealed plans to pilot advertising on ChatGPT, marking a significant shift in how nonprofits might engage with audiences. Key Highlights: OpenAI's Announcement: OpenAI is testing ads in select markets for ChatGPT's free and low-cost tiers, aiming to provide more users with access to its AI tools without usage limits. Implications for Nonprofits: With approximately 800 million weekly active users, ChatGPT offers nonprofits a vast audience for targeted advertising. This presents an unprecedented opportunity to engage users during meaningful conversations across diverse contexts, from education to health advice. Concerns and Opportunities: While the prospect of ads in AI raises concerns about data privacy and the influence on AI-generated content, it also opens doors for nonprofits to reach audiences in innovative ways. The challenge will be crafting ad content that complements AI interactions without disrupting user trust. Transparency and Analytics: The move towards advertising may also introduce valuable analytics tools, enabling nonprofits to gain insights into user behavior and optimize their engagement strategies. Nonprofit Wellness Index Update: The podcast also highlights Whole Whale's Nonprofit Wellness Index, which tracks sector health through job postings, layoffs, and ad spending. December's index hit a record high, indicating a positive rebound from previous lows, suggesting a revitalized nonprofit sector. Feel-Good Story: In a lighter segment, the hosts share a unique fundraising initiative from an Alaskan bird conservation group. For Valentine's Day, donors can name a rat after an ex, which will then be fed to a bird of prey, offering both cathartic satisfaction and support for wildlife conservation.

AI Ads: A New Frontier for Nonprofits This week on the Nonprofit Newsfeed the hosts dive into a game-changing announcement from OpenAI that could revolutionize nonprofit marketing strategies. OpenAI has revealed plans to pilot advertising on ChatGPT, marking a significant shift in how nonprofits might engage with audiences. Key Highlights: OpenAI's Announcement: OpenAI is testing ads in select markets for ChatGPT's free and low-cost tiers, aiming to provide more users with access to its AI tools without usage limits. Implications for Nonprofits: With approximately 800 million weekly active users, ChatGPT offers nonprofits a vast audience for targeted advertising. This presents an unprecedented opportunity to engage users during meaningful conversations across diverse contexts, from education to health advice. Concerns and Opportunities: While the prospect of ads in AI raises concerns about data privacy and the influence on AI-generated content, it also opens doors for nonprofits to reach audiences in innovative ways. The challenge will be crafting ad content that complements AI interactions without disrupting user trust. Transparency and Analytics: The move towards advertising may also introduce valuable analytics tools, enabling nonprofits to gain insights into user behavior and optimize their engagement strategies. Nonprofit Wellness Index Update: The podcast also highlights Whole Whale's Nonprofit Wellness Index, which tracks sector health through job postings, layoffs, and ad spending. December's index hit a record high, indicating a positive rebound from previous lows, suggesting a revitalized nonprofit sector. Feel-Good Story: In a lighter segment, the hosts share a unique fundraising initiative from an Alaskan bird conservation group. For Valentine's Day, donors can name a rat after an ex, which will then be fed to a bird of prey, offering both cathartic satisfaction and support for wildlife conservation.

What if obesity and metabolic dysfunction start in the muscle, not the fat tissue we usually measure? In this episode of New Frontiers in Functional Medicine, Dr. Kara Fitzgerald and Dr. Gabrielle Lyon unpack this emerging science, from intramuscular adipose tissue to protein needs, anabolic resistance, fatty liver disease, and the role of muscle in healthy aging. A compelling episode with immediate takeaways for clinical practice. Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources. GUEST DETAILS Dr. Gabrielle Lyon is the physician behind Muscle-Centric Medicine®, a groundbreaking approach that reframes muscle as the key driver of metabolic health, aging, and resilience. She is the bestselling author of FOREVER STRONG and the forthcoming Forever Strong Playbook, which translates her science-backed principles into practical strategies for building lifelong strength and capacity. Website: https://drgabriellelyon.com/ Instagram: https://www.instagram.com/drgabriellelyon/ YouTube: https://www.youtube.com/@DrGabrielleLyon THANKS TO OUR DIAMOND SPONSORS Biotics Research: https://bit.ly/2IHK6Xd DUTCH: https://dutchtest.com/for-providers Time—Line Nutrition: https://tinyurl.com/bdzx2xms EXCLUSIVE OFFERS FROM OUR SPONSORS Find out why MitoQ's mitochondria-targeting is a critical step for your healthspan and longevity strategy. http://mitoq.com/drkara *CONNECT with DrKF* Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz YouTube: https://tinyurl.com/hjpc8daz Instagram: https://www.instagram.com/drkarafitzgerald/ Facebook: https://www.facebook.com/DrKaraFitzgerald/ DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb Younger You Practitioner Training Program: www.drkarafitzgerald.com/trainingyyi/ Younger You book: https://tinyurl.com/mr4d9tym Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw

Premise For decades, the standard leadership playbook has been built upon an ironclad, yet increasingly fragile, triad: vision, strategy, and execution. While these pillars are foundational, they are no longer sufficient to navigate the complexities of the modern knowledge economy. A significant, transformative chapter is missing from the manual—one that addresses the human engine of performance. We have been conditioned to believe that leadership is exclusively "serious work" and that joy is a frivolous activity, which is at best emerges as after work activities and at worst considered a liability to be checked at the door.   This cultural perception has architected a structural deficit in our organizations. Leaders and their teams find themselves "drudging to work," trapped in a cycle of professional survival rather than creative thrive-states. This has led to a significant percentage of of employees having checked out at work and just going through the motions.   We treat fun as a distraction, something reserved for after-hours or relegated to the periphery of "real" work. This is one of the most damaging assumptions in modern business. It creates a false dichotomy that suggests one must choose between delivering results and experiencing joy. As an Executive Leadership coach, I contend that this dichotomy is not only false but strategically dangerous. Treating play as a distraction rather than a performance engine directly degrades a team's capacity for innovation.  In an era where the primary differentiator is the quality of thought, the traditional leadership playbook is suffering from a cognitive bottleneck. To remain competitive, we must dismantle this outdated view and recognize that play is a competitive necessity, a high-performance engine designed to galvanize teams and produce superior outcomes. The High-Performance Definition of Play To leverage play as a strategic asset, we must first strip away the superficiality that often surrounds the concept in corporate circles.  Strategic play is not found in the aesthetics of Silicon Valley—it is not about installing ping-pong tables, stocking breakrooms with board games, or the hollow performance of "mandated fun" events that often feel more like an obligation than an escape. These are mere pastimes; they do not drive performance. Instead, we must adopt an operational definition: play as an intentional, high-performance psychological and physiological state.  It is about architecting an environment where teams can achieve a state of "flow" while tackling their most rigorous and demanding objectives. In this state, the traditional friction of work evaporates and teams end up doing a lot more work with a lot less stress.  This lack of stress, despite the immense workload proves that play is not the absence of work; it is the absence of the psychological friction that usually accompanies work. When work is operationalized as play, the team doesn't just work harder; they work with a clarity and resilience that "serious" drudgery can never replicate. Six Elements of Play To move from theory to tactical application, we must look at the structural components of play. Organizational researcher Scott Eberle identified six core elements that define a playful mindset.  When leaders intentionally weave these elements into the cultural fabric of their teams, they transform the very nature of the work being produced. 1. Anticipation: The Catalyst for Engagement Anticipation is the palpable excitement that arises from looking forward to a challenge. In a professional context, this is the antidote to "initiative fatigue." Just as an athlete anticipates the opening whistle, a high-performing team thrives when the challenge ahead is framed not as a burden, but as an opportunity for discovery. Anticipation acts as the mental "hook." In modern business environments, specifically those utilizing Agile methodologies, anticipation transforms a "backlog" from a list of chores into a series of upcoming hurdles to be cleared. It primes the team to be mentally "in the game" before the first line of code is written or the first slide is designed. 2. Surprise: Disrupting Cognitive Entrenchment Surprise involves the novelty and unexpected discoveries encountered during a project. Significant challenges naturally produce new insights, both positive and negative. Surprise is the primary catalyst for innovation. In a "serious" environment, the unexpected is often viewed as a risk to be mitigated. In a playful environment, surprise is welcomed as a means to break routine thinking and force the brain to make new, non-linear connections. It disrupts "cognitive entrenchment"—the tendency for experts to rely on outdated mental models—and opens the door for genuine breakthroughs. 3. Pleasure: Sustaining the Performance Loop Pleasure is the intrinsic satisfaction derived from the activity itself. When the reward is the work, the team is in the process of achieving a sustainable loop of high performance. In many organizations, motivation is extrinsic—driven by bonuses, titles, or fear. Pleasure, however, provides a more durable fuel. It ensures that high-quality output is driven by internal satisfaction, which significantly reduces the attrition and burnout associated with high-pressure environments. 4. Understanding: The Currency of Progress Understanding is the "aha!" moment—the specific point in time when a complex problem is seen from a fresh perspective and the mental gears finally click into place. In the knowledge economy, these moments of insight are our most valuable currency. By fostering a playful environment, leaders lower the "cognitive load" and reduce the pressure that often blocks insight. This makes these "clicks" of understanding more frequent and more profound. 5. Strength: Architecting Mastery Strength is the feeling of competence and mastery that follows the process of overcoming a challenge. It is the psychological "high" of knowing one is capable, skilled, and efficacious. Mastery builds the confidence necessary for calculated risk-taking. When a team feels "strong" in their capabilities, they are more likely to push boundaries and explore unconventional solutions. This sense of mastery is the foundation of a "growth mindset" within the organization. 6. Poise: The Buffer Against Crisis Poise is the sense of grace, composure, and confidence that comes from operating at one's peak performance. It is the hallmark of a leader who is fully present. Poise is the ultimate defense against the "amygdala hijack"—the stress response that shuts down higher-order thinking during a crisis. A team operating with poise can remain calm and effective under extreme pressure, ensuring that they bring their "A-game" to high-stakes situations without being paralyzed by the fear of failure. The Chemical Formula for Peak Performance These six elements are not a buffet from which to choose from. They function as a unified chemical formula. When orchestrated correctly, they prime the brain for engagement and move the team toward a state of "effortless mastery or FLOW".  The formula functions through specific pairings that build a narrative of performance: Anticipation and Surprise (The Priming Phase): These two elements work in tandem to prime the brain for engagement. Anticipation focuses the attention, while surprise keeps the brain plastic and receptive to new information. This combination prevents the stagnation that occurs when work becomes predictable and monotonous. Pleasure (The Fuel Phase): Pleasure provides the intrinsic motivation necessary to sustain high effort over the long term. It is the cooling system for the high-performance engine, allowing for "immense hard work" without the friction of stress. Understanding and Strength (The Immersion Phase): These elements build the confidence required for deep immersion. When a team feels they understand the problem space and possess the strength to navigate it, they can commit fully to the task. This eliminates the "imposter syndrome" and hesitation that often slow down innovation. Poise (The Flow Phase): Poise is the result—the effortless mastery that defines a "flow state." It is the pinnacle of performance where the individual or team operates at maximum potential, moving through complex tasks with a sense of grace and composure. In an economy where the primary differentiator is the "quality of thought," the ability to architect an environment for consistent flow is the single greatest lever a leader possesses. If the brain is stressed, it is physiologically incapable of producing high-quality thinking. By using this chemical formula, you are literally optimizing the neurochemistry of your organization. Quantifying the ROI of Play or Joy The integration of play is not a "soft" initiative; it is a cold, calculated investment in Cultural Resilience.  For the strategist, the ROI of play or joy is measurable, when looked through three distinct lens: Personal Impact: The Executive Shield For the individual leader, the benefits of a playful mindset are immediate. It enhances the ability to solve complex, "wicked" problems by unlocking new creative connections that are inaccessible in a state of drudgery.  More importantly, it acts as a critical defense against burnout. By reducing work-related stress, play builds individual resilience, ensuring that the leader's productivity remains top-notch even during periods of extreme volatility and work under high pressure situations.  Team Impact: The Trust Foundation When play is integrated into a team, the impact is transformative. It allows for a level of bonding that traditional "team-building" exercises, which often feel artificial, cannot match.  Play strengthens communication and forges a powerful sense of togetherness through shared challenges and shared insights.  It builds a foundation of psychological safety where team members feel comfortable being vulnerable and taking risks. As the principle states: "Teams that play together stay together." Organizational Impact: The Strategic Asset At scale, this approach defines the entire organization. A culture where joy is expected is a culture worth belonging to.  This manifests as higher employee engagement, a free flow of creative ideation, and a measurable increase in overall productivity. It turns the organization into a "fulfilling place to work," a powerful differentiator in the war for talent.  When play is a core component of the culture, the organization becomes more agile, more innovative, and more capable of enduring market shifts. The Leader's Mandate - Be a Role Model The evidence is no longer anecdotal; it is a proven strategy for high performance. Therefore, the responsibility for integrating play falls directly on the shoulders of leadership.  It is time to dismantle the false dichotomy between results and joy and acknowledge that play is a non-negotiable component of delivering high-quality work. However, this cannot be mandated through policy. You cannot "order" a team to be in flow.  Instead, leaders must model the behavior. This is the Leader's Mandate: you must demonstrate through your own actions that fun is not only "okay" but is expected. What does this look like in practice? It means: Tactical Transparency: Openly celebrating a "Surprise" or an "Understanding" moment during a high-stakes meeting. Auditing Drudgery: Regularly asking, "Which parts of our current process have become mere drudgery, and how can we re-inject Anticipation or Surprise into them?" Celebrating Process, Not Just Outcome: Acknowledging the brilliance and the growth of the team even when a project doesn't reach the market or is seen as unsuccessful.  Projecting Poise: Demonstrating composure and a "playful" curiosity during a crisis, rather than signaling panic. When a leader brings their "A-game" with poise and visible enjoyment, they create the psychological safety necessary for their teams to do the same.  They signal that the work is important enough to be enjoyed. Conclusion The legacy a leader builds is ultimately defined by the environment they create. We are moving past the era of professional drudgery and into an era where the most successful organizations will be those that have operationalized joy through integrating the elements of play.  Exceptional results and genuine joy are not mutually exclusive—they are one and the same. By intentionally fostering a playful mindset and engineering an environment for flow, you do more than just build a successful organization - you create a space where teams can do their best work while actually thriving in the process.  You move from being a manager of tasks to being an architect of fulfillment. And when you integrate your AI agents into the flow of things by calling on them in each element of play and sharing their perspective, in addition to the team, you are now becoming a leader who understands how to leverage the strengths of both human and AI agents who are now part of your team. As you look at your own leadership style and the culture you are currently cultivating, ask yourself the most fundamental question of all: "Are we having fun working together?" https://youtu.be/FF7NIt0PFw8  

Fierce First Step in 2026 PodcastFIVE PRIMARY POINTS of the PODCASTLiving in the “Vitality Zone” Requires Conscious Choice and CourageDr. Mishra contrasts the vitality zone—where life feels purposeful, energetic, and engaged—with the surviving, sliding, and burnout zones. Using his experience standing on Iceland's continental divide as a metaphor, he emphasizes that meaningful growth often requires a deliberate leap of faith rather than passive autopilot living.Sleep is the New Frontier for Disease PredictionGroundbreaking AI research (the Sleep Foundation Model) shows that data from a single night of sleep can predict over 130 health conditions, including dementia, heart disease, stroke, and all-cause mortality. Sleep is reframed not as passive rest, but as a powerful diagnostic signal for future health.Sleep Functions as a Biological and Metabolic SuperpowerHigh-quality sleep resets metabolism, reduces inflammation, preserves muscle mass, improves cognition, and enhances physical performance. Athletes, professionals, and everyday individuals perform better when sleep is prioritized, making it foundational for both vitality and productivity.Five Evidence-based Principles can Dramatically Improve Sleep QualityThe most impactful strategies are:* Prioritizing sleep regularity over total sleep duration* Using exercise (especially strength training) as a drug-free sleep aid* Executing consistent sleep hygiene (cool, dark room; limited screens/caffeine; calming routines)* Recognizing sleep as a performance enhancer and metabolic reset* Treating sleep data as a validated biomarker for long-term health riskKnowledge only Matters when Turned into ActionEchoing Benjamin Franklin, Dr. Mishra stresses that while knowledge pays dividends, action pays more. The concrete vitality action for the week is simple but powerful: aim for 20 additional minutes of quality sleep per night, combined with moments of stillness, reflection, and self-advocacy to move intentionally toward a more vital life.Copyright VyVerse, LLC. All Rights Reserved. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit vitalityexplorers.substack.com/subscribe

Epilepsy affects millions, but few people know about the fascinating relationship between music and epilepsy, and that research is looking at how music may help reduce seizure activity in some individuals. Dr. Phillip Pearl, Harvard neurologist and professional jazz musician, shares how sound is being studied as a tool in epilepsy care (and many other applications). Links and notes related to this episode can be found at https://mpetersonmusic.com/podcast/episode226 Connect with us: Newsletter: https://mpetersonmusic.com/subscribe Facebook: https://www.facebook.com/EnhanceLifeMusic/ Instagram: https://www.instagram.com/enhancelifemusic/ LinkedIn: https://www.linkedin.com/in/mpetersonpiano/ X: https://twitter.com/musicenhances Sponsorship information: https://mpetersonmusic.com/podcast/sponsor Leave us a review on Podchaser.com! https://www.podchaser.com/podcasts/enhance-life-with-music-909096 In-episode promo: Sheet Music Direct https://www.sheetmusicdirect.com

The Cognitive Crucible is a forum that presents different perspectives and emerging thought leadership related to the information environment. The opinions expressed by guests are their own, and do not necessarily reflect the views of or endorsement by the Information Professionals Association. During this episode, Anthony Vinci, author of The Fourth Intelligence Revolution, discusses how the battlefield has shifted from physical territory to the human brain. From China's influence within U.S. education and gaming to the subtle "mind hacking" potential of AI-generated misinformation, Anthony breaks down the strategic landscape of modern information operations. Join us for a deep dive into the risks posed by TikTok, the crisis of masculinity in the digital age, and how we can build individual resilience against an era of total surveillance. Recording Date: 8 Jan 2026 Resources: Cognitive Crucible Podcast Episodes Mentioned #100 Rand Waltzman on the Metaverse and Immersive Virtual Reality #212 Libby Lange on Algorithmic Cognitive Warfare The Fourth Intelligence Revolution: The Future of Espionage and the Battle to Save America by Anthony Vinci The Age of Surveillance Capitalism: The Fight for a Human Future at the New Frontier of Power by Shoshana Zuboff Princeton Review Link to full show notes and resources Guest Bio: Anthony Vinci is the author of The Fourth Intelligence Revolution: The Future of Espionage and the Battle to Save America (Henry Holt, 2025). He served as the first Chief Technology Officer at the National Geospatial-Intelligence Agency (NGA) where he was one of the first leaders to bring AI into intelligence. Earlier in his career he served in Iraq, Africa, and Asia. After leaving the world of intelligence, Vinci became an executive at a private equity firm and CEO of VICO, an AI company that is bringing the intelligence revolution to the rest of us by democratizing intelligence analysis. He is an Adjunct Senior Fellow at the Center for a New American Security (CNAS) and received his PhD in International Relations from the London School of Economics. About: The Information Professionals Association (IPA) is a non-profit organization dedicated to exploring the role of information activities, such as influence and cognitive security, within the national security sector and helping to bridge the divide between operations and research. Its goal is to increase interdisciplinary collaboration between scholars and practitioners and policymakers with an interest in this domain. For more information, please contact us at communications@information-professionals.org. Or, connect directly with The Cognitive Crucible podcast host, John Bicknell, on LinkedIn. Disclosure: As an Amazon Associate, 1) IPA earns from qualifying purchases, 2) IPA gets commissions for purchases made through links in this post.

Get ready for a lively discussion as JSS explore the unique and often hilarious side of contemporary dating. We'll take you on a journey that includes dating app settings, personal preferences, and the intriguing idea of using Facebook Marketplace as a tool for meeting potential partners. Witness as Program Director, Justin Johnson, navigates the local dating scene in Baltimore, sharing candid thoughts on his current experiences, and learn about the clever strategies he's employing to find that special someone amidst life's unpredictable circumstances.

In this episode (watch here on YouTube), we dive into one of the most talked-about areas of emerging Parkinson's research: GLP-1 receptor agonists. Originally developed for diabetes and, more recently, widely used for weight management, GLP-1 medications like semaglutide and liraglutide are now being investigated for their potential neuroprotective effects. We explore: -What GLP-1 receptor agonists are and how they work -Why these medications might have benefits beyond blood sugar control -The current research examining GLP-1s in Parkinson's disease -Possible mechanisms, including inflammation reduction, mitochondrial support, and improved cellular signaling -What early clinical trials suggest—and what we still need to learn -Considerations, cautions, and why these medications are not yet approved for Parkinson's treatment Whether you're a person living with Parkinson's, a care partner, a clinician, or someone curious about the future of neurodegenerative disease research, this episode offers a clear and balanced look at an exciting and evolving topic.  Help to support this channel and out efforts to educate the world about Parkinson's Disease and get access to personalized content:  https://www.youtube.com/channel/UC0g3abv8hkaqZbGD8y1dfYQ/join  https://www.patreon.com/pdeducation  Please be sure to give support to our channel sponsors: Comfort Linen: https://comfortlinen.com/PARKINSONSDISEASEEDUCATION(15% off entire order when applying the code PARKINSONSDISEASEEDUCATION at checkout) Kizik Shoes: https://kizik.sjv.io/pdeducation Cure Hydration: https://lvnta.com/lv_XG06Rho8SSlXEq3qlV If you have products that you would like for me to review on the channel please send them here: Parkinson's Disease Education P.O. Box 1678 Broken Arrow, OK 74013 Medical Disclaimer All information, content, and material of this video is for informational purposes only and not intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified physician or healthcare provider. Affiliate disclaimer: Keep in mind that links used for recommended products may earn me a commission when you make purchases. However, this does not impact what products I recommend. If I recommend a specific product it is because it has been vetted by myself or based on personal use. #parkinson #parkinsonsawareness #parkinsonsdisease #parkinsons #glp1 #glp1medication #research

Exosomes are becoming one of the most talked-about tools in regenerative medicine, but not all exosomes are created equal. In this episode of New Frontiers, Dr. Kara Fitzgerald talks with Alisa Lask, CEO of Plated Skin, about the science behind platelet-derived exosomes and why their signaling pathways matter for repair, renewal, and changes in skin appearance. We explore how discoveries in cardiology led to this technology, what early clinical studies are showing, and why source and preparation are critical when evaluating any exosome-based approach. A clear, grounded look at a fast-moving field for clinicians who want to understand what's real, what's emerging, and what deserves attention next. Full show notes + references: https://www.drkarafitzgerald.com/fxmed-podcast/ GUEST DETAILS Alisa Lask is the CEO of Rion Aesthetics, where she is driving innovation in regenerative aesthetics with platelet-derived exosomes and leading research in areas like hair restoration and skin appearance. She also oversees (plated)™ Skin Science, a medical-grade exosome skincare line distributed through aesthetic providers. Alisa previously held senior roles at Galderma, Allergan, Zimmer-Biomet, and Eli Lilly, and she serves on the Board of Directors for CollPlant. She holds an MBA from the University of Michigan and is also a nationally competitive show-jumping equestrian involved in dog rescue initiatives. THANKS TO OUR SPONSOR (plated)™ Skin Science: http://platedskinscience.com/ Plated Skin Science translates the discovery of Dr. Atta Behfar, M.D., Ph.D., Director of Mayo Clinic's Van Cleve Cardiac Regenerative Medicine Program into the first shelf-stable skincare line using regenerative, platelet-derived exosomes. These aren't generic exosomes; they're a specific class shown in peer-reviewed trials to regenerate skin's appearance by improving the look of wrinkles, pigmentation, luminosity, and overall skin quality. It's an elegant approach to visible signs of skin aging, recognized by Time as a Best Invention of 2024 and now used in more than 2,000 medical practices. Learn more at http://platedskinscience.com/ CONNECT with DrKF Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz YouTube: https://tinyurl.com/hjpc8daz Instagram: https://www.instagram.com/drkarafitzgerald/ Facebook: https://www.facebook.com/DrKaraFitzgerald/ DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb Younger You Practitioner Training Program: www.drkarafitzgerald.com/trainingyyi/ Younger You book: https://tinyurl.com/mr4d9tym Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw

Shipping frozen premium meats and prepared meals requires precise logistics that most marketplaces aren't built to handle. But Denys Gorbatiuk saw an opportunity where others saw impossible complexity. Grumpy Butcher became Temu's first frozen food seller and proved that operational excellence can break down expansion barriers and create a competitive advantage.Within five weeks, Temu accounted for over 12% of Grumpy Butcher's online sales. Yet the real story isn't just about velocity, it's about reaching younger demographics and using real-time data to fundamentally rethink product creation and curation.From corporate attorney to food industry innovator, Denys shares how mastering the operational challenges of frozen logistics, leveraging platform analytics, and partnering strategically with Temu transformed Grumpy Butcher from a pandemic-era startup into a fast-growing business that redefined how Americans shop for gourmet perishables.Shipping the Impossible – With **Operational ExcellenceKey takeaways:Being first in a hard category pays off: Pioneering frozen food on Temu positioned Grumpy Butcher as a category leader and innovator.Direct feedback and engagement with shoppers on Temu enabled product development, revealing stronger resonance with younger customers and reshaping the broader business strategy.Mastering complex logistics is defensible: Streamlining frozen food delivery and tackling common challenges helped Grumpy Butcher establish its core competitive advantage.Platform partnership means strategic collaboration: Temu provided operational support and guidance that went beyond transactional seller-marketplace relationships.In-Show Mentions:Learn more about Grumpy Butcher's journey on TemuExplore Temu's seller services and marketplace solutionsAssociated Links:Check out Future Commerce on YouTubeCheck out Future Commerce Plus for exclusive content and save on merch and printSubscribe to Insiders and The Senses to read more about what we are witnessing in the commerce worldListen to our other episodes of Future CommerceHave any questions or comments about the show? Let us know on futurecommerce.com, or reach out to us on Twitter, Facebook, Instagram, or LinkedIn. We love hearing from our listeners! Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

We love to do deep dives into trends that we are noticing in painting and the trend of “Bordercore” was one of our best-loved from the year, so we decided to revisit it this holiday season. We take a look at the emergent trend in art which is wild and inventive takes on frames, suddenly front and center for many painters of the moment as a way to push new boundaries in painting.  Almost by definition, the frame of a picture is something that you are not supposed to notice. But if you go to the art galleries to look at paintings now, you might get a very different sense of what a frame can or even should do. Weird and wild frames that very much draw attention to themselves seem to be having a moment. Recently, Artnet writer and editor Katie White penned a piece titled “Bordercore: Why Frames Became the New Frontier in Contemporary Art,” in it, she writes:  A new wave of contemporary art is reconsidering the frame as a central character, one that is surreal, sculptural, and symbolic. Artists are using the border not just to contain, but to comment, disrupt, or extend the work beyond itself. This is driven by an embrace of more bespoke, historic artistic processes, but also, as a rebuttal to the superflat virtual age. More and more, paintings have been appearing at fairs and in exhibitions with statement frames, after a long era of often-frameless display. If for previous generations, the frame was a liability that could detract from the cerebral, intellectual, and aesthetic experience of the canvas, artists today are creating frames that attempt to pull us back into bodily reality, a haptic experience of art. In her essay, she looks both at the history of framing styles, and talks to a number of contemporary painters to figure out what is causing so many to treat something that was literally considered peripheral to what they do as very much part of the main attraction. This week she joins art critic Ben Davis on the podcast to discuss this new frontier in art.

Welcome to this episode of The Edge of Show recorded live at the Future of Money, Governance, and the Law (FOMGL) event in Washington, D.C. In this conversation,Josh Kriger is joined by Craig Salm, Ryan VanGrack, Kyle Hauptman, and Jon Ungerland for a candid breakdown of the rapidly evolving world of FinTech, blockchain, and digital assets. Together, they dig into regulatory clarity, the rise of DeFi, shifting consumer behaviors, and what recent policy moves mean for the future of money.Key Highlights:How regulatory uncertainty impacts builders, investors, and institutionsThe rise of DeFi and new expectations around decentralized servicesWhat recent SEC changes signal for digital assetsHow local financial institutions adapt to new money networksPredictions for the future of money and innovation in U.S. financeThis episode is for policymakers, innovators, and industry leaders who want to explore how emerging technologies are reshaping finance.Support us through our Sponsors! ☕

Functional dentistry is emerging as a powerful missing link in systems-based care. In this episode of New Frontiers in Functional Medicine, Dr. Kara Fitzgerald sits down with Staci Whitman, DMD, IFMCP, a leading voice in functional pediatric dentistry and co-founder of the upcoming Institute for Functional Dentistry. Together, they explore how the oral microbiome, airway health, saliva, hormones, nutrition, and stress physiology shape systemic inflammation, chronic disease risk, and long-term health outcomes. You'll learn how to recognize oral contributors to gut issues, autoimmunity, cardiometabolic disease, cognitive decline, sleep disorders, and more—plus practical tools you can use right away in a medical setting, including a simple five-question airway and breathing screener. If you're looking to expand your longevity and whole-body health framework, this conversation offers clear, actionable insights you won't want to miss. Full show notes + references: https://www.drkarafitzgerald.com/fxmed-podcast/ GUEST DETAILS Dr. Staci Whitman is a board-certified pediatric and functional dentist and co-founder of the Institute for Functional Dentistry (IFD). She integrates the oral microbiome, airway and sleep health, nutrition, hormones, and early childhood development into modern dental care. She also founded Bloom Kids Dentistry and has an upcoming book on the oral microbiome. Website: http://doctorstaci.com THANKS TO OUR SPONSORS DIAMOND DUTCH: https://dutchtest.com/for-providers Biotics Research: https://bit.ly/2IHK6Xd GOLD TimeLine Nutrition: https://tinyurl.com/bdzx2xms Vibrant Wellness: https://www.vibrant-wellness.com/ EXCLUSIVE OFFERS FROM OUR SPONSORS OneSkin: Get 15% off OneSkin with the code DRKARA at http://oneskin.co/DRKARA Find out why MitoQ's mitochondria-targeting is a critical step for your healthspan and longevity strategy. http://mitoq.com/drkara *CONNECT with DrKF* Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz YouTube: https://tinyurl.com/hjpc8daz Instagram: https://www.instagram.com/drkarafitzgerald/ Facebook: https://www.facebook.com/DrKaraFitzgerald/ DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb Younger You Practitioner Training Program: www.drkarafitzgerald.com/trainingyyi/ Younger You book: https://tinyurl.com/mr4d9tym Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw