Podcast appearances and mentions of Yusra Mardini

Matkovich: A DK épp átjátssza Vácot a Fidesznek 24.hu     2025-04-17 05:58:25     Belföld Fidesz Pest DK Vác Belső feszültségek nehezítik a Matkovich Ilona vezette összefogás munkáját, a helyzetnek a Fidesz lehet a legnagyobb nyertese. Lebukott a hangyabanda, több ezer hangyát találtak két belga fiatalnál Telex     2025-04-17 06:26:01     Külföld Belgium Kenya Kémcsövekben őrizték a hangyákat, most zaklatott állapotban jelentek meg a kenyai fővárosban tartott tárgyalásukon, ahol szüleik vigasztalták őket. Elindultam, amikor már nem volt biztos, túlélem-e, ha elhagyom a házat Forbes     2025-04-17 05:12:07     Gazdaság Olimpia Szíria Forbes Tíz évvel a menekülése után visszatérhetett Szíriába Yusra Mardini. Most, a Forbes Power Women's Summit előadójaként Magyarországra – egykori útja egyik állomására – is ellátogatott, így közvetlenül mesélt nekünk arról, milyen volt tíz év után látni lebombázott otthonát, az uszodát, ahol olimpiai úszónak készült, és mindenkit, akit otthon hagyott. Életed hány százalékát töltötted eddig a NER-ben? 444.hu     2025-04-17 05:59:23     Belföld Fidesz NER Átlagmagyar az élete több mint harmadát a kétharmados Fidesz-világban pergette le. Te hogy állsz? Brazíliába menekült legkisebb fiával a volt perui elnök felesége Magyar Hírlap     2025-04-16 22:43:00     Külföld Brazília Menekült Peru A volt elnök felesége és 14 éves fia helyi idő szerint szerdán kora reggel, egy értük küldött brazil kormánygép fedélzetén hagyták el az országot. Azt kell nézni, hogy mi biztosítja az államadósságráta csökkentését – interjú a Költségvetési Tanács elnökével mfor.hu     2025-04-17 05:54:05     Gazdaság Interjú Államadósság Olyan viharok alakítják a különböző országok fiskális megítélését, amelyekhez képest a magyar államadósság-mutató minimális kilengésének és a deficitcél tavalyi elvétésének kevésbé van jelentősége -mondta a lapunknak adott interjúban Horváth Gábor. A Költségvetési Tanács elnöke óva intette a gazdaságpolitikát attól, hogy német mintára élénkítésbe f Vegán étrendben is gazdag lehet a húsvéti menü Sokszínű vidék     2025-04-17 06:03:00     Életmód Húsvét Vegetarianizmus Vegán Húsvéti kalács, répatorta, saláták, fasírtok, hamis tojáskrém és még "sonkatekercs" is készíthető a vegán húsvéti asztalra. Házat vett a hét év alatt összegyűjtött 450 ezer palackból egy férfi - elárulta a módszerét Startlap Vásárlás     2025-04-17 05:33:59     Gazdaság Ausztrália Egy ausztrál férfi hét év alatt több mint 450 ezer alumíniumdobozt és műanyagpalackot gyűjtött össze és váltott vissza, a pénzből pedig sikerült megvennie első otthonát. Vádemelés lehetőségére figyelmezteti egy bíró Trump elnököt Euronews     2025-04-16 22:54:46     Külföld Donald Trump Bevándorlás Salvador Boasberg bíró elrendelte, hogy bizonyos bevándorlókat ne toloncoljanak ki. A döntés ellenére a Trump-adminisztráció deportálta őket Salvadorba Pert nyertek Jakabos Zsuzsáék a magyar állam ellen, 200 millió forint jár nekik Telex     2025-04-17 04:48:02     Sport Bíróság Kamat Hiába szereztek összesen 11 aranyérmet a 2022-es Világjátékokon, a minisztérium szerint nem minden sportolót illetett volna meg a rendeletben meghatározott jutalom. Nyolc úszó, köztük Európa-bajnokok is perre mentek, és a bíróság másodfokon nekik adott igazat: kamatostul ki kell fizetni őket. Ezúttal elmaradt a Real Madrid-csoda, legjobb négy között az Arsenal a BL-ben! Sportal     2025-04-16 23:05:00     Foci Spanyolország Bajnokok Ligája London Real Madrid Arsenal A visszavágón sem forgott veszélyben az Arsenal továbbjutása, a londoni klub kettős sikerrel a negyeddöntőben kiejtette a Bajnokok Ligája rekordgyőztesét, a Real Madridot. Villámfényes éjszakánk lesz Kiderül     2025-04-17 05:20:47     Időjárás Csapadék Csütörtökön este mediterrán ciklon csapadékrendszere éri el hazánkat. Többfelé számíthatunk ismétlődő záporok, zivatarok kialakulására. A további adásainkat keresd a podcast.hirstart.hu oldalunkon.

Matkovich: A DK épp átjátssza Vácot a Fidesznek 24.hu     2025-04-17 05:58:25     Belföld Fidesz Pest DK Vác Belső feszültségek nehezítik a Matkovich Ilona vezette összefogás munkáját, a helyzetnek a Fidesz lehet a legnagyobb nyertese. Lebukott a hangyabanda, több ezer hangyát találtak két belga fiatalnál Telex     2025-04-17 06:26:01     Külföld Belgium Kenya Kémcsövekben őrizték a hangyákat, most zaklatott állapotban jelentek meg a kenyai fővárosban tartott tárgyalásukon, ahol szüleik vigasztalták őket. Elindultam, amikor már nem volt biztos, túlélem-e, ha elhagyom a házat Forbes     2025-04-17 05:12:07     Gazdaság Olimpia Szíria Forbes Tíz évvel a menekülése után visszatérhetett Szíriába Yusra Mardini. Most, a Forbes Power Women's Summit előadójaként Magyarországra – egykori útja egyik állomására – is ellátogatott, így közvetlenül mesélt nekünk arról, milyen volt tíz év után látni lebombázott otthonát, az uszodát, ahol olimpiai úszónak készült, és mindenkit, akit otthon hagyott. Életed hány százalékát töltötted eddig a NER-ben? 444.hu     2025-04-17 05:59:23     Belföld Fidesz NER Átlagmagyar az élete több mint harmadát a kétharmados Fidesz-világban pergette le. Te hogy állsz? Brazíliába menekült legkisebb fiával a volt perui elnök felesége Magyar Hírlap     2025-04-16 22:43:00     Külföld Brazília Menekült Peru A volt elnök felesége és 14 éves fia helyi idő szerint szerdán kora reggel, egy értük küldött brazil kormánygép fedélzetén hagyták el az országot. Azt kell nézni, hogy mi biztosítja az államadósságráta csökkentését – interjú a Költségvetési Tanács elnökével mfor.hu     2025-04-17 05:54:05     Gazdaság Interjú Államadósság Olyan viharok alakítják a különböző országok fiskális megítélését, amelyekhez képest a magyar államadósság-mutató minimális kilengésének és a deficitcél tavalyi elvétésének kevésbé van jelentősége -mondta a lapunknak adott interjúban Horváth Gábor. A Költségvetési Tanács elnöke óva intette a gazdaságpolitikát attól, hogy német mintára élénkítésbe f Vegán étrendben is gazdag lehet a húsvéti menü Sokszínű vidék     2025-04-17 06:03:00     Életmód Húsvét Vegetarianizmus Vegán Húsvéti kalács, répatorta, saláták, fasírtok, hamis tojáskrém és még "sonkatekercs" is készíthető a vegán húsvéti asztalra. Házat vett a hét év alatt összegyűjtött 450 ezer palackból egy férfi - elárulta a módszerét Startlap Vásárlás     2025-04-17 05:33:59     Gazdaság Ausztrália Egy ausztrál férfi hét év alatt több mint 450 ezer alumíniumdobozt és műanyagpalackot gyűjtött össze és váltott vissza, a pénzből pedig sikerült megvennie első otthonát. Vádemelés lehetőségére figyelmezteti egy bíró Trump elnököt Euronews     2025-04-16 22:54:46     Külföld Donald Trump Bevándorlás Salvador Boasberg bíró elrendelte, hogy bizonyos bevándorlókat ne toloncoljanak ki. A döntés ellenére a Trump-adminisztráció deportálta őket Salvadorba Pert nyertek Jakabos Zsuzsáék a magyar állam ellen, 200 millió forint jár nekik Telex     2025-04-17 04:48:02     Sport Bíróság Kamat Hiába szereztek összesen 11 aranyérmet a 2022-es Világjátékokon, a minisztérium szerint nem minden sportolót illetett volna meg a rendeletben meghatározott jutalom. Nyolc úszó, köztük Európa-bajnokok is perre mentek, és a bíróság másodfokon nekik adott igazat: kamatostul ki kell fizetni őket. Ezúttal elmaradt a Real Madrid-csoda, legjobb négy között az Arsenal a BL-ben! Sportal     2025-04-16 23:05:00     Foci Spanyolország Bajnokok Ligája London Real Madrid Arsenal A visszavágón sem forgott veszélyben az Arsenal továbbjutása, a londoni klub kettős sikerrel a negyeddöntőben kiejtette a Bajnokok Ligája rekordgyőztesét, a Real Madridot. Villámfényes éjszakánk lesz Kiderül     2025-04-17 05:20:47     Időjárás Csapadék Csütörtökön este mediterrán ciklon csapadékrendszere éri el hazánkat. Többfelé számíthatunk ismétlődő záporok, zivatarok kialakulására. A további adásainkat keresd a podcast.hirstart.hu oldalunkon.

Though we are celebrating Women's History Month, we all started out as girls. So this week, Madigan brings you the stories of six fabulous young feminists, whose small statures did nothing to hold them back from changing the world. Subjects: Sophie Scholl, Zinaida Portnova, Yusra Mardini, Janna Jihad and her cousin Ahed Tamimi, and lastly, Thandiwe Abdullah. DEMAND PROTECTION FOR JANNA: https://www.amnesty.org/en/petition/opt-demand-protection-for-janna/ Do you have a topic that you want the show to take on?    Email: neighborhoodfeminist@gmail.com Social media:     Instagram: @angryneighborhoodfeminist Get YANF Merch! https://yanfpodcast.threadless.com/ JOIN ME ON PATREON!! https://www.patreon.com/angryneighborhoodfeminist Sources: https://greatness.com/olympian-yusra-mardinis-incredible-story-of-resilience-rescue-and-refugee-rights/ https://www.npr.org/sections/thetwo-way/2016/03/20/471180243/after-surviving-aegean-sea-syrian-swimmer-hopes-for-spot-in-olympics https://swimswam.com/refugee-swimmer-yusra-mardini-gets-chance-go-olympic-games/ https://web.archive.org/web/20180127004507/http://www.thedawn-news.org/2016/05/18/voice-for-the-voiceless-palestines-10-year-old-journalist-janna-jihad/ https://web.archive.org/web/20180712090411/https://wearyourvoicemag.com/identities/feminism/530-daily-share-10-year-old-journalist-janna-jihad-reports-palestine https://www.arabnews.com/node/1474336/media https://www.usatoday.com/story/news/world/2017/12/19/israel-arrests-palestinian-girl-ahed-tamimi-over-viral-video-soldier-slapping/966542001/ https://web.archive.org/web/20171230114524/https://www.cbsnews.com/news/palestinian-teen-ahed-tamimi-prosecuted-israel-attack-soldiers-nebi-saleh/ https://www.seventeen.com/life/a34717855/thandiwe-abdullah-black-lives-matter-voices-of-the-year-2020/ https://medium.com/illumination/how-a-17-year-old-soviet-fighter-became-a-feminist-superhero-3711bf98a6f Learn more about your ad choices. Visit megaphone.fm/adchoices

There's enough space on this planet for everyone. Syrian refugee and 2x Olympic swimmer Yusra Mardini had some of her life's defining moments depicted in the Netflix film The Swimmers. A member of the inaugural IOC Refugee team, Yusra has become a global figure advocating on behalf of refugees and displaced communities, and through her Yusra Mardini Foundation, helps advance access to sports and education for refugee communities around the world while also helping them excel as they rebuild their lives. Yusra is now enrolled in film school at USC and while competitive swimming has taken a back seat to the many other priorities on her plate, she still makes time to stay fit and enjoy a conversation with some laughs talking about swimming and about life.

From questioning Kamala Harris's ethnic identity to his long-standing birther claims against Barack Obama, racist attacks against his political opponents have become part of Donald Trump's political playbook. Harvard professor and racial politics scholar, Randall Kennedy joins Bianna Golodryga to examine how Trump weaponizes racism to undermine his opponents.  Then Nicholas Thompson and Emily Glazer unpack the dangers of misinformation on democracy, social media's role, and Musk's impact on the AI sector, as race riots rattle the UK.  After escaping the Taliban's brutal crackdown, the Afghan Youth Orchestra is now rebuilding their lives in Portugal. Young musicians describe their unimaginable hardship, and discuss the power of music as a symbol of hope. From the archive, as Nicolas Maduro attempts to maintain his grip on power amid a contested election in Venezuela, Christiane Amanpour's 2014 conversation reveals his defiance in the face of mass protests and widespread claims of election fraud is nothing new. Finally, two-time Olympian, Yusra Mardini reflects on the resilience of the Refugee Olympic Team. Learn more about your ad choices. Visit podcastchoices.com/adchoices

One day in and it's been a rapturous reception for VP candidate and Minnesota Governor Tim Walz. Today he and running mate Kamala Harris are stumping in Wisconsin after an enthusiastic debut in Philadelphia. Congressman Brendan Boyle is a longtime friend of Walz and a congressman for the crucial swing state of Pennsylvania. He joins the show to discuss the new vice presidential candidate.  Also: correspondent Jeremy Diamond reports from northern Israel; US National Security Adviser Jake Sullivan; Will Carter, Sudan Country Director, Norwegian Refugee Council; Yusra Mardini, former swimmer, Refugee Olympic Team  Learn more about your ad choices. Visit podcastchoices.com/adchoices

Recorded Live at Spotify Beach in Cannes Olympic swimmer and Syrian refugee Yusra Mardini fled the Syrian Civil War with her sister Sara, making the perilous journey to Europe at only seventeen, including a treacherous crossing of the Aegean Sea in 2015. After finding refuge in Germany, Yusra was selected to compete as part of the inaugural Refugee Olympic Team at the 2016 Olympics in Rio de Janeiro and again in Tokyo four years later. On World Refugee Day 2023, Yusra announced the launch of her nonprofit, The Yusra Mardini Foundation, which aims to improve access to sports and education for refugee communities. Yusra has become a powerful advocate for forcibly displaced people worldwide. Episode 61 explores the challenges of living in a war-torn country, the importance of not judging refugees, and how to use your voice to make a positive impact. We discuss: - Being born in Syria - Beginning to swim at age 3 - Dreaming of becoming the next Michael Phelps at age 9 - Facing the onset of war at age 13 - Enduring the traumas of the Syrian conflict - Undertaking a 25-day journey from Syria to Germany - Crossing the Aegean Sea on a dinghy - Keeping the Olympic dream alive - Helping establish the Refugee Olympic Team - Aims to change the perception of refugees Chapters: (00:00:00) Fleeing Syria at 13 years old (00:02:18) From Syria to Olympic Swimming (00:04:48) Starting Swimming at a Young Age (00:07:27) The Daily Routine in Damascus (00:09:55) Witnessing the Start of War in Syria (00:12:23) Mourning the Loss in Syria (00:14:51) The Youth Olympic Games and Political Reasons for Quitting Swimming (00:17:10) Pursuing a Different Path in Life (00:19:22) Life in a War Zone (00:21:30) Packing for the Journey (00:26:24) The Expensive Boat Journey (00:28:44) Guardian Angels on the Boat (00:31:10) Heartbreaking Journey across the Ocean (00:33:25) A Life-Threatening Situation at Sea (00:35:40) The Rescue at Sea (00:37:58) Journey to Germany (00:40:26) Impressive Syrian Swimmers (00:42:39) Representing a Refugee Olympic Team (00:45:14) The Impact of the Olympic Stadium (00:47:37) Competing at the Olympics (00:49:54) The Struggles and Dreams of Refugees (00:52:19) Refugees and Stereotypes in the UK (00:54:49) The Importance of Welcoming Immigrants in Society (00:57:10) Supporting the Refugee Olympic Team (00:59:32) A Heartwarming Moment (01:01:59) A Heartfelt Story of Gratitude ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Watch on YouTube⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow us ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@HOWIBECAME__⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ We're on ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠TikTok⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠X⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ and ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Facebook⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Email: info@weunify.co.uk Credits: Director: Charles Parkinson Poet & VO Artist: Ashley Samuels-McKenzie Editor: Catherine Singh

Meet Yusra Mardini:  When the Syrian civil war broke out, Yusra Mardini and her sister fled. Eventually finding refuge in Germany, Yusra reignited her passion for swimming, joining the newly formed Olympic Refugee Team. Now, she's at the helm of the Yusra Mardini Foundation, an organization dedicated to advancing access to sports and education for refugee communities around the world.     In this episode, host Gautam Mukunda speaks with Yusra about how she navigates challenges, leads by example and builds organizations that last.      Notable Timestamps    2:40 Olympics     5:20 Leading for others    9:40 Having your leadership tested    13:45 Building organizations that last    Resources Referenced     Epstein, D. J. (2019). Range: Why Generalists Triumph in a Specialized World. New York, Riverhead Books.    Follow @GMukunda on Twitter or email us at WorldReimagined@nasdaq.com   For more information on this episode's guest please visit:   Nasdaq.com/world-reimagined-podcast    

تشاركنا يسرى مارديني، السباحة الأولمبية السورية المتميزة، رحلتها الاستثنائية في برنامجنا. قامت يسرى مع أختها سارة مارديني بمهمة إنقاذ جريئة، حيث أنقذوا قاربًا مليئًا باللاجئين - وهي قصة آسرة أسرت الجماهير في فيلم نيتفليكس "السباحون". تسرد يسرى التفاصيل المذهلة لهذه القصة الملهمة وتتأمل في التأثير العميق لإحيائها كفيلم من أفلام نيتفليكس. تنفتح على طفولتها، العلاقة الخاصة التي تشاركها مع أختها وأهدافها القادمة. انضموا إلينا هذا الثلاثاء في اكتشاف الإنسان خلف لقب السباحه يسرى مارديني.

Yusra Mardini describes her incredible journey from being a Syrian refugee to chasing her dream and becoming an Olympic swimmer and how important events like SIARA 2023 are for refugees around the world. Listen to #Pulse95Radio in the UAE by tuning in on your radio (95.00 FM) or online on our website: www.pulse95radio.com ************************ Follow us on Social. www.facebook.com/pulse95radio www.twitter.com/pulse95radio www.instagram.com/pulse95radio www.youtube.com/pulse95radio

Tolo Leal nos cuenta la historia de esta gran deportista con una historia personal brutal

We talk to Hassan Akkad, who came to the UK as an asylum seeker from Syria and who earned a BAFTA for his BBC documentary ‘Exodus: Our Journey to Europe', which used real footage from his journey from Syria.  Hassan tells us about his short film, ‘Matar', which tells the story of a day in the life asylum-seeker Matar as he tries to survive in London without being able to work legally or have a bank account.   ‘Matar' stars Ahmed Malek, who recently starred in ‘The Swimmers', the feature film about the Mardini sisters escaping war-torn Syria.  Both superb swimmers, the sisters sought asylum in Germany and Yusra Mardini went on to earn an Olympic gold medal.  Hassan also tells us about projecting his short 90 second message ‘Led by Donkeys' onto the White Cliffs of Dover.  We also talk to Shomit Dutta, who wrote the play ‘Stumped' about an imaginary game of cricket between Harold Pinter and Samuel Beckett, and to Andrew Lancel, who plays Pinter in the play. Who knew that Beckett, played in ‘Stumped' by Stephen Tompkinson, is the only Nobel Prize Winner to have an entry in Wisden?  Shomit and Andrew discuss the joys of cricket and the dramatic opportunities the game offers to explore the friendship between two of the greatest dramatists of our time. ‘Matar' can be viewed free here at Waterbear.com. ‘Stumped' plays at Theatre Royal Bath between 23rd and 27th May, at Cambridge Arts Theatre between 5th and 10th June and finally at the Hampstead Theatre in London between 16th June and the 22nd July.  Follow us on Facebook, Twitter, Instagram

Yusra Mardini, a Syrian refugee who competed in the Rio Olympics (2016) with the Refugee Olympic Team. Yusra's love for swimming, passed down from her father, helped her overcome unimaginable adversity. She now uses her platform to raise awareness about the plight of refugees worldwide, speaking at the United Nations and inspiring others with her remarkable story. Time Stamps: (00:00) Introduction (03:10) Attack on Yusra's Swimming Gymnasium (04:31) Life threatening journey to Lesbos (06:00) Yusra's reflections on the treatment of refugees (08:15) Impact of the Mardini sisters' story (08:55) Sarah Mardini is arrested (09:45) Lessons from Yusra's journey

With Passover and Easter upon us, this time of year, we often think about the meaning of freedom, survival, and renewal. Directed by Sally El Hosaini from a screenplay that she co-wrote with Jack Thorne, The Swimmers is a 2022 biographical sports drama film dealing with similar themes. The plot follows the true life story of teenage Syrian refugees Yusra Mardini and her sister Sarah Mardini, who swam alongside a sinking dinghy of refugees to lighten it, and eventually help 18 refugees to reach safety across the Aegean Sea while being smuggled from İzmir towards Lesbos. Subsequent struggles as refugees are vividly depicted, but Yusra Mardini's swimming career sees her reaching the Rio 2016 Olympics as a member of the Refugee Olympic Team. In the final credits, we learn that Sarah in 2016 returned to Lesbos as part of voluntary efforts to assist incoming refugees. She was arrested and faces charges carrying potentially long-term prison sentences, if convicted. Yusra and Sarah are played by real-life sister Lebanese Actresses, Nathalie Issa & Manal Issa. The film also stars, Ahmed Malek, German Actor, Matthias Schweighöfer (playing The Swimming Coach),  Ali Suliman, Kinda Alloush, James Krishna Floyd and Elmi Rashid Elmi. November 11, 2022 it was in limited release in cinemas, then shown at the evening gala of the Marrakesh International Film Festival on November 18, 2022, before its streaming release by Netflix, on November 23, 2022. As accredited media, I was at its world premiere red carpet Gala and Q & A at the 2022 Toronto International Film Festival on September 8, 2022 to conduct interviews and discuss the status of refugees, freedom, and the importance of pursuing your dreams. Enjoy this episode with my compliments this Passover/Easter weekend!

Welcome to the second season of The Imperfect Clinician!In the last episode of second season we expand on the discussion about collaboration in the team. How do we know it is healthy? How do we ensure it stays healthy? IS there a place for fun in the team? Join us for the discussion.In the final #YuenReads of this season - part of our podcast where Yuen shares the books that made a difference for Yuen and inspired her deeply. These are not book reviews - she considers impact those reads had on her - this time Yuen talks about 'Butterfly' by Yusra Mardini.Thank you for deciding to spend some time with us! Enjoy Season 2!SEASON 3 COMING SOON - IN MID MAY! Keep an eye on our socials for exact date!Sign up, subscribe to make sure you hear when we come back with the new material! Don't miss it!If you want to embark on a journey to better You, start with joining us on ours.Consider subscribing to our newsletter on our website - there is a special surprise exclusive for subscribers!!!Join The Imperfect Clinician on:Website https://www.theimperfectclinician.comFacebook https://www.facebook.com/theimperfectclinicianInstagram https://www.instagram.com/theimperfectclinician/Twitter https://twitter.com/ImperfClinicianYouTube https://www.youtube.com/@theimperfectclinicianTikTok https://www.tiktok.com/@imperfclinicianMastodon site https://primarycare.app/@theimperfectclinicianMastodon username @theimperfectclinician@primarycare.appemail theimperfectclinician@gmail.comAvailable on our website, Spotify, Apple Podcasts, Samsung Free, Google Podcasts and most other podcast platforms and apps as well as on YouTube.

Tom knows all too well that athletes who make it to an Olympic Games must face trials and tribulations along the way, but few have had to overcome what Yusra Mardini did to make their sporting dreams come true.As the war in Yusra's home country intensified, she left to seek safety for her and her family in Europe. In this episode, she speaks about the traumatic journey to Germany that followed, and what it was like to literally swim for her life when the small boat she was traveling in began to take on water. Not one to dwell on the negative, Yusra speaks passionately about the power of love and kindness in the face of adversity, and how finding hope and positivity in difficult situations is the key, not just to success, but also survival.Yusra also shares what her life was like in Syria, including growing up with her father as her coach! Why a break from doing what she loved reignited her passion, and how representing her parents at the Olympics was the start of a beautiful journey to accepting her status as a refugee and embracing all that she is.--------------------------------------------------------------------------------------------------------------------------------------Below are some of the charities and organisations Yusra mentions in this episode:- The Swimmers- Free Humanitarians- #DropTheCharges Petition- There is a documentary about Sara Mardini's story – The Long Distance Swimmer: Sara Mardini – and you can find out more about Sara's story here- Yusra Mardini Foundation- Give Your Best UK- Choose Love- Epimonia Hosted on Acast. See acast.com/privacy for more information.

EP 22 — sereen talks about her girls cabin trip, the electricity blacking out in winter, yusra mardini the syrian refugee olympic swimmer, tik tok era & the obsession with going viral, yoga highs and lows + grounding tips and more!- JOURNAL HIJABI'S INSTAGRAM: https://www.instagram.com/journalhijabi/ - Hosted and created by Sereen Qader (@sereenqader) ⠀- Email for Inquiries: journalhijabi@gmail.com⠀⠀Thank you for tuning in and spending time to listen to this episode. If you could take a moment to support this podcast by sharing it and leaving an honest review, it would mean so much to me and help us to reach many different audiences to spread our stories about the Hijab. Never forget the power of being a Hijabi!Journal Hijabi was crafted as a creative outlet outside of a full-time job and graduate school. Each episode is a labor of love to spread more informative stories about our hijab. Help show your support by buying me a “coffee” to continue sustaining future journal hijabi episodes! https://www.buymeacoffee.com/journalhijabi Hosted on Acast. See acast.com/privacy for more information.

La historia de Sara y Yusra Mardini inspiró ‘Las Nadadoras', una película que relata la huida de dos campeonas de natación sirias a Europa por la guerra. Años después de llegar a la isla griega de Lesbos, Sara regresó para ayudar a migrantes y refugiados. Pero hacerlo le significó un proceso legal en su contra, que la lleva a los estrados junto con otros 23 trabajadores humanitarios. Este no es el único caso que criminaliza la solidaridad en Europa. 

I can't find the right words to do enough justice to Yusra Mardini's story. I think it's best that you just listen to the episode. Suffice it to say, she's one of the most impressive people I've ever met. Yusra grew up in Damascus. When war broke out, she and her sister embarked on a perilous journey to Germany to seek asylum. En route, they nearly died when the dinghy they were using to cross the Aegean sea had an engine failure. Yusra and her sister Sara - both competitive swimmers - jumped overboard and helped to pull the boat to safety, saving all 18 people on board.Yusra went on to compete in the 2016 Olympics, to become the youngest ever UNHCR Goodwill Ambassador and to publish a memoir that has now been made into a Netflix movie, The Swimmers.Listen now to hear Yusra telling her story. It's unbelievably powerful.--The Swimmers is available to watch on Netflix--Choose Love does amazing work for refugees. If you'd like to donate or learn more, please visit their website here.--How To Fail With Elizabeth Day is hosted and produced by Elizabeth Day. To contact us, email howtofailpod@gmail.com--Social Media:Elizabeth Day @elizabdayHow To Fail @howtofailpodYusra Mardini @yusramardini

Natalie tells you about Sara and Yusra Mardini, refugee sisters who saved the lives of others and went on to do great things! *The picture on the episode comes from the New York Times.

On Episode 23 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the December 2022 issue of Stroke: “Direct, Indirect, and Combined Extracranial-to-Intracranial Bypass for Adult Moyamoya Disease” and “Contemporary Incidence and Burden of Cerebral Venous Sinus Thrombosis in Children of the United States.” She also interviews Drs. Koji Tanaka and Andrew Demchuk about article “Significance of Baseline Ischemic Core Volume on Stroke Outcome After EVT in Patients Age ≥75 Years.” Dr. Negar Asdaghi:         Let's start with some questions. 1) Is direct bypass better than indirect bypass in preventing the future risk of vascular events in adult patients with moyamoya disease? 2) What is the contemporary incidence of cerebral venous sinus thrombosis in the pediatric population? 3) And finally, is endovascular therapy beneficial for patients presenting with a large ischemic core? We have the answers and much more in today's podcast. You're listening to the Stroke Alert Podcast, and this is the best in Stroke. Stay with us. Welcome back to another issue of the Stroke Alert Podcast. My name is Negar Asdaghi. I'm an Associate Professor of Neurology at the University of Miami Miller School of Medicine and your host for the monthly Stroke Alert Podcast. In our final podcast for the year, I'm thrilled to announce that Drs. Nastajjia Krementz and Eric Goldstein have joined our podcast as assistant editors to help us cover the latest and the best in the field of cerebrovascular disorder. And together, here's our article selection to close the year. As part of our Advances in Stroke, in the article titled "Focus on Anticoagulation for Valvular Heart Disease With and Without Atrial Fibrillation," we get an update on current evidence from randomized controlled trials on the use of direct oral anticoagulants or vitamin K antagonists in patients with valvular heart disease that are mechanical valves, moderate to severe mitral stenosis, or bioprosthetic valves from the perspective of stroke physicians. What that means is that data from randomized trials was analyzed based on whether the patient had a prior history of stroke or TIA. In this review, we learned that direct oral anticoagulants may be used in patients with bioprosthetic valves who have atrial fibrillation, although DOACs have never been shown to be superior over vitamin K antagonists. We also learned that vitamin K antagonists should be used in patients with rheumatic moderate to severe mitral valve stenosis or patients with mechanical valves with or without atrial fibrillation and, of course, sometimes during the first few months after either surgical or transcatheter aortic valve replacement in patients without atrial fibrillation. And finally, patients with bioprosthetic valves without AFib don't have any other indications to be treated with anticoagulants should be treated with antiplatelet monotherapy in the long run. In a separate article in this issue of the journal, from Dr. Yang and colleagues from China, we learn about the pathophysiology of radiation-induced brain injury with special attention to radiation-induced vasculopathy. These investigators show that hyperactivity of notch signaling pathway that in normal state is essential in vascular morphogenesis and maintenance of arterial identity actually results in abnormal accumulation and disturbance of vascular smooth muscle cells, resulting in arterial muscularization and arterial dysfunction seen in radiation-induced vasculopathy. What's interesting is that inhibition of the notch signaling pathway in their study resulted not only in a measurable reduction in radiation induced vasculopathy, but also an overall improvement in radiation-induced brain injury as measured by the cognitive function of the mice exposed to radiation in their study. This study takes us a step closer to possible therapeutic options for radiation-induced vasculopathy and radiation-induced brain injury using compounds that can potentially inhibit the notch signaling pathway. As always, I encourage you to review these articles in detail in addition to listening to our podcast. For our interview today, I have a special guest who's not only a prominent researcher and a pioneer in the field of acute stroke therapies, but also, he's an experienced educator who has trained many of the current leaders in the field of vascular neurology and has been influential in shaping the careers of many vascular neurology fellows over the years. Take a listen. Dr. Andrew Demchuk:   I've had the privilege of training fellows. I've been the director since 2004, and we've trained close to 100 fellows in Calgary over 20-some years now. Really, it's frankly an honor and privilege to be able to do that. These individuals come from all over the world. They're here to dedicate themselves to learning a subspecialty really, really well, and it's just a fantastic experience to interact with them all and all their cultures to help them learn those things, and doing it in a fun, enjoyable, comprehensive way. Dr. Negar Asdaghi:         And those are the words of Dr. Andrew Demchuk, who's incidentally my own vascular fellowship director as well. Andrew joins me all the way from Canada to talk about his latest paper on the very hot topic of outcomes of endovascular therapy in patients presenting with a large ischemic core. And true to form, he's accompanied by one of his current vascular fellows. The interview is definitely worth the wait after we review these two articles. Most of us have heard of the term "moyamoya." First described in Japan in 1950s, the term refers to occlusion or stenosis of the terminal portion of the internal carotid artery and is associated with dilated collateral vessels of the proximal middle cerebral artery. These collaterals have a hazy appearance on angiography resembling the puff of smoke, which is Japanese for "moyamoya." Moyamoya is categorized into two broad categories of moyamoya syndrome and moyamoya disease. Syndrome refers to the situations where the occlusion occurs due to another condition. Conditions such as Down syndrome, sickle cell disease, neurofibromatosis type one have all been recognized as associated with moyamoya syndrome. Of course, moyamoya syndrome can occur due to a secondary insult to the blood vessels, anything from radiation vasculopathy, as we reviewed earlier in the podcast, to autoimmune vasculitis, or even good old advanced intracranial atherosclerosis involving the distal ICA region can cause moyamoya syndrome. Now, in contrast to moyamoya syndrome, the term "moyamoya disease" is reserved for individuals with no vascular risk factors or known moyamoya predisposing conditions other than, of course, some potential genetic factors. The most recognized genetic association for moyamoya disease is polymorphism in the ring finger protein 213, or RNF213, gene on chromosome 17. But we also have to keep in mind that the majority of moyamoya disease patients have no identified genetic abnormalities. So, moyamoya is truly a complex condition, and the physicians have to navigate the many possible etiologies that may cause or be associated with this condition. But when it comes to treatment options, we're really limited here. Antiplatelets are generally used and have been shown to reduce mortality in both moyamoya disease and syndrome, and especially cilostazol, which is the favorite antiplatelet therapy of our own assistant editor, Eric, has been shown to be significantly associated with increased survival rate in patients with moyamoya disease. Eric really wanted me to talk about a recently published study out of Korea, which included over 9,000 patients, and that showed that patients treated with cilostazol had a better survival rate than any other antiplatelet therapies. Apart from antiplatelet therapies, medical treatment includes optimizing all other vascular risk factors, which, as we mentioned, are rarely present in this population. So, it all comes down to most cases, at some point, needing surgical treatment, with bypass surgery being the most commonly surgical intervention for this population. Three flavors of bypass are used: indirect, direct, or combination of the two. Indirect bypasses are kind of like long-term investments where the surgeon moves vascular tissue to the surface of the brain in hopes of promoting angiogenesis. Several procedures, such as performing multiple burr holes, pial synangiosis, dural inversion, or omental transposition, among other methods, are used. And broadly speaking, we can think of indirect procedures as angiogenesis-dependent methods, the effect of which takes months to recognize and, in general, are thought to be more efficacious in the pediatric population than the adult population. The direct bypass, in contrast, commonly referred to as extracranial-to-intracranial, or ECIC, bypass, is more of an immediate reward where the surgeon stitches a vessel directly from a donor extracranial branch, typically the superficial temporal artery, to a recipient artery, typically the middle cerebral artery, to provide a direct anastomosis between the two vessels. There are technical variations, of course, especially with regards to the number of donors and recipient arteries used, but essentially this method is an angiogenesis-independent method that results in a quicker revascularization, but it's unclear if this strategy is long lasting. A combination of direct and indirect bypass can also be used. So, the question is, which method is better, especially in the adult population? In this issue of the journal, in the study titled "Direct, Indirect, and Combined ECIC Bypass for Adult Moyamoya Disease," Dr. Nickalus Khan and colleagues report on a meta-analysis and systematic review of those with adult moyamoya disease who underwent either direct, indirect, or a combination bypass. The main study question was whether there's a difference in the rates of early ischemic or hemorrhagic strokes, defined as strokes occurring within 30 days of bypass, or late strokes, defined as strokes occurring after 30 days of bypass, in this population when comparing the different surgical techniques. They also compared the "favorable" outcome rate; however, this outcome was defined in each study between the various broad techniques of direct, indirect, and combined bypass. So, with that, let's take a very quick look at their methodology. They screened more than 4,000 articles and identified 143 articles for their pooled analysis, the majority of articles being from Eastern Asian-based regions, and they had close to 4,000 combined, 4,000 direct, and 4,000 indirect bypass procedures for this analysis. And they had an average follow-up of over three and a half years. So, this is a great sample size for this large, pooled analysis. But they also performed a smaller meta-analysis where they were much more stringent with article selection, excluding pediatric papers, excluding articles containing only one surgical modality, or articles with insufficient outcome data. So, for that meta-analysis, they only had 43 articles qualified and were included in that meta-analysis. So, what did they find? In the larger pooled analysis, a significant benefit in favor of both direct and combined bypass techniques were noted in reduction of early and late ischemic strokes and late intracerebral hemorrhage. Also, a higher rate of that sort of vague favorable outcome was noted with both the direct or combined methods as compared to when indirect bypass techniques were used alone. So, everything in the large, pooled analysis pointed towards the direct bypass or combined technique performing better than all indirect bypass techniques, with only one exception, which was a lower incidence of early intracerebral hemorrhage rate in indirect bypass cases. So, that's one point to keep in mind. The second point was when they compared combined techniques to direct bypass. Overall, these procedures had more or less the same outcomes with the exception that the rate of late ischemic stroke was lower in the combined group than the direct bypass group. So, this is sort of the overall summary of what they found in that large, pooled analysis. When they were much more stringent with their selection criteria, focusing on the smaller meta-analysis portion of the study, what they found was that in the short term, there were no differences in outcomes of any type of stroke between any of these methods. So, basically, people, regardless of the type of bypasses they received, did the same with regards to the risk of intracerebral hemorrhage and ischemic stroke recurrence within the first 30 days after the bypass. But for the late stroke outcomes, whether ischemic or hemorrhagic, those with indirect bypass were nearly twofold more likely to develop late stroke after 30 days compared to those who've undergone the direct bypass. A similar pattern was found comparing combined bypass versus indirect bypass, in general, beyond the 30 days, with combined bypass doing better. Comparing direct versus combined bypass showed no difference regardless of timeframe. So, in summary, overall, it appears that combined or direct bypasses may be the best surgical strategies for treatment of adult patients with moyamoya disease. This study, of course, has many limitations, as does any meta-analysis, but most importantly, the authors focused on moyamoya disease in their analysis. It is presumed, but really unclear if patients with moyamoya syndrome would respond similarly to these different techniques. So, the question is, what surgical procedure are you using at your institution for treatment of adult moyamoya disease patients? And, of course, Eric wanted me to ask if your antiplatelet of choice is cilostazol for this population, yes or no. Leave us your comments, and let us know. Venous sinus thrombosis, or CVST, is a less common form of stroke most commonly affecting women and young individuals. In our past podcast, we've covered many aspects of CVST, especially when it comes to therapy with anticoagulation, anticoagulant of choice, and duration of therapy. In the October podcast, we reviewed a systematic review and meta-analysis comparing direct oral anticoagulants to vitamin K antagonists in the adult patients with CVST. But there are many aspects of this disease that we have not yet covered. For instance, you may ask, how common is this relatively uncommon condition? In the adult population, the incidence of CVST varies depending on the age of individuals studied, and ranges between 1.3 to 2.7 per 100,000 in women between the ages of 31 to 50, which is the adult population at highest risk for this disease. But the incidence of CVST, for instance, in the pediatric population is largely unknown. Some studies suggested an incidence rate of 0.67 per 100,000 in the pediatric population. That's roughly less than half the incidence rate in young female adults, but these reports are from the 1990s and are likely very outdated. Nowadays, many of the pediatric conditions, especially infectious conditions, that can predispose children to CVST are more readily diagnosed and treated. On the other hand, we now perform a lot more imaging than 30 years ago. Our neuroimaging modalities are more accurate, so we are more likely to diagnose CVST than before. So, the question is, what is the contemporary incidence of pediatric cerebral venous sinus thrombosis? In this issue of the journal, in the study titled "Contemporary Incidence and Burden of Cerebral Venous Sinus Thrombosis in Children of the United States," Dr. Fadar Otite and colleagues conducted a retrospective analysis of the New York State Inpatient Database, or SID, from 2006 to 2018, and the National Kids Inpatient Database, referred to as KID, from 2006 to 2019, for all hospitalized CVST cases. KID is the largest publicly-available pediatric inpatient care database in the United States, containing about 3 million pediatric discharges. They included over 700 hospitalized CVST cases from the SID database and 6,100 hospitalizations from the national KID database for the current analysis. And here's what they found. Number one, in terms of significant risk factors associated with CVST, congenital circulatory system anomalies, infections, head trauma, dehydration, and anemia were amongst the top CVST risk factors in the pediatric population. So that's very good to know. Number two, in terms of presentation, seizures were the most common presentation among all pediatric age groups, with close to half of infants with CVST presenting with seizures. Number three, in terms of outcomes, the rate of mortality was twice higher in the infants group as compared to all other age groups. And finally, the overall incidence of CVST, which was the main question of the paper, in this population was 1.1 per 100,000 per year, with a peak incidence during infancy of 6.4 per 100,000 per year. Interestingly, incident admissions also increased annually by 3.8% throughout the study period, which was close to 15 years in this paper. And the national burden of hospitalization dramatically and exponentially grew during the study period. So, here are the top three points from this study. Point one: Girls included less than half of all admissions nationally and statewide, and the overall burden of CVST was higher in boys than girls. That's a dramatic difference between the pediatric and adult populations. Point two: Incidence of CVST in infants was higher than five times that of other age groups at 6.4 per 100,000 compared to overall incidence in children, which was 1.1 per 100,000 people per year. Mortality was also two times higher in infants than in any other age group. And finally, point 3, incident admissions and national burden of hospitalization have dramatically increased over time, but it remains unclear whether true incidence has been on the rise or if simply more cases are recognized nowadays due to heightened awareness of this condition and our advanced neuroimaging capabilities. This study, of course, has some limitations. Data was only obtained on patients admitted, so many patients that may have had CVST but not admitted are not captured in this database. So, in summary, CVST can have catastrophic consequences in children and lead to long-term neurological deficits. Having a high clinical suspicion and early recognition remain crucial for prompt treatment and improved outcomes in this population. Dr. Negar Asdaghi:         Endovascular treatment, or EVT, is an effective method to achieve recanalization and to improve clinical outcomes in ischemic stroke patients with a target vessel occlusion. Both advanced age and having a large infarct volume at the time of presentation are negative predictors of beneficial outcomes post-EVT. Despite this, the neurological benefits of EVT seem to persist across the spectrum of age, and the same has been observed for a range of ischemic core volumes. But it's important to note that, in general, patients presenting with large ischemic core volumes were excluded from the original thrombectomy studies, and currently there's several ongoing trials to determine whether EVT is beneficial for the large core population. Now, the question that everyone is interested in answering is whether there is an actual ischemic core volume beyond which endovascular therapy is either futile or potentially even harmful, and if this magic futile core volume is the same for all patients, or does it differ depending on the age and other factors. In a previous podcast, in an interview with Dr. Osama Zaidat, we learned about that important interaction between the presenting ischemic core volume as measured by ASPECTS score and advanced age in an analysis of patients enrolled in the STRATIS registry. In that study, no one over the age of 75 achieved functional independence post-EVT if the presenting ASPECTS score was under 5 regardless of the angiographic outcomes. In that interview, we also discussed the limitations of STRATIS registry as a non-randomized, single-arm study, and the issues surrounding using ASPECTS score to define ischemic core. In today's podcast, we're going to revisit the important interaction between the presenting ischemic core volume and age while reviewing a pooled analysis of seven endovascular clinical trials in the paper titled "Significance of Baseline Ischemic Core Volume on Stroke Outcome After Endovascular Therapy in Patients Age 75 Years or Older." I'm delighted to be joined today by the first and senior authors of this paper, Drs. Koji Tanaka and Andrew Demchuk. Dr. Tanaka is an Assistant Professor of Neurology at Kyushu University in Japan. With his experience working at the leading center for conducting stroke clinical trials in Osaka, he has now joined the Calgary Stroke Program as a research fellow. And he's accompanied today by his fellowship director, Dr. Demchuk. Dr. Demchuk, of course, needs no introduction to our Stroke readership and our podcast audience. He's a Professor of Neurology at the University of Calgary Cumming School of Medicine. He's a stroke neurologist and a leader in the field of cerebrovascular research who has been involved in multiple clinical studies and randomized trials, including the seminal studies that led to the approval of EVT as the standard of care for treatment of stroke. And, of course, he's a very special guest of this podcast this morning as he was my very own fellowship director. Top of the morning to you both, Andrew and Koji. Welcome to the podcast. Dr. Andrew Demchuk:   Thanks, Negar. It's great to be here. Dr. Koji Tanaka:               Thank you very much for your invitation. That is a great honor to be here. Dr. Negar Asdaghi:         Thank you both. Andrew, let's start with you. Can you please provide us some background on the pooled analysis and the HERMES collaboration, please? Dr. Andrew Demchuk:   Yeah, HERMES is a really, it's been a really fun journey. Years back, when these trials all came out roughly at the same time, right? There was a real quick succession of trials, the MR CLEAN trial was obviously first, and ESCAPE and others quickly followed it. It became very clear to us that it just made total sense to collaborate. And so we got together as a group and decided we will pool the data. We'll do it in a very careful scientific way with basically an independent statistical analysis, and develop a core imaging lab, and really actually share the workload amongst us. I remember one of the really interesting tidbits about HERMES is when we got together, in order, I think, to really build trust in the group, one of the important things we decided early was we were going to have a snake draft. If you don't know what a snake draft is, Negar, it's essentially where you take turns selecting a topic through each of the trials. So, every trialist got an opportunity to pick a topic, and we just went down the list until everyone had their turn, and then we'd start over again and do it again. And I think that really worked very well to be as democratic as possible with this, and as fair. And it really allowed for a lot to get done because whoever was motivated in the collaboration was able to do an analysis. Dr. Negar Asdaghi:         So, what a great summary of this collaboration. So, it's true collaboration between the trialists that basically gave us those seven original randomized trials. Andrew, can I just stay with you, and can you tell us a little bit about the patient population that were enrolled in those trials? Dr. Andrew Demchuk:   Yeah, I think one of the important things to know, and I think a limitation for any kind of analysis like this, is the trials generally were small core trials, right? I mean there are some, MR CLEAN was certainly a more generalized population, but many other trials, including ESCAPE, I mean the "S" and the "C" in ESCAPE is "small core," right? And so a lot of these trials were small core. So, we don't have a lot of data in larger core patients. But, as you can imagine when you do core lab analysis, you realize that some of the stroke patients weren't as small core as we thought they were when we enrolled them. So, there is some sufficient data to hypothesize. I would consider this paper very much hypothesis-generating. So, yeah, it is a limitation to be considered here. I mean, our sample size isn't very large in the big core patients. Dr. Negar Asdaghi:         Perfect. Thank you, Andrew. So, again, a recap for our listeners, that we are looking at pooled analysis of seven original trials of thrombectomy, but keeping in mind that those patients that were enrolled in the trials had, generally speaking, small presenting ischemic core. So, now, Koji, on to you. Can you walk us please through the current study, and what was the premise of it, and who was actually included in this study? Dr. Koji Tanaka:               Yes. In this study, we aimed to evaluate association between baseline ischemic core volume and the benefit of endovascular therapy over the best medical treatment on functional outcomes. Patients were categorized age over 75 years, and less than 75 years old. The primary outcome of interest was a modified Rankin Scale of three or less, and we included 899 patients who underwent this baseline ischemic core volume measurement, which corresponds to 51% of our patients in the HERMES collaboration dataset. Dr. Negar Asdaghi:         All right. So, just a quick recap of what you said. Thank you for this. So, we have 899 patients. Those patients were all included in the HERMES collaboration, but, of course, these are patients in whom we had presenting ischemic core measurements. And that will get me, actually, Koji, to my second question. Can you please walk us through how you did analysis of ischemic core volume measurements in this study? Dr. Koji Tanaka:               In this study, ischemic core volume was measured by CT perfusion in 591 patients and by diffusion-weighted imaging in 309 patients. We defined the ischemic core volume as a relative cerebral blood flow of less than 30% in CT perfusion and diffusion coefficient of less than 620 square micrometers per second in diffusion-weighted imaging. Previous studies showed ASPECTS moderately correlate with ischemic core volume in both CT perfusion and diffusion-weighted imaging. For example, ASPECTS of eight can be considered as ischemic core volume of 20 milliliters. But underlying [inaudible 00:28:21] were different between CT perfusion and diffusion-weighted imaging, and previous studies suggested CT perfusion occasionally overestimates the ischemic core volume was on diffusion-weighted imaging. In this study, the results did not change when analyzing CT perfusion and diffusion-weighted imaging separately. Dr. Andrew Demchuk:   Yeah, that's a really important point Koji makes, is that because we had sort of a, not quite a 50/50 split, we had a 60/40 split of CTP and DWI, we did analyze them separately, and the odds ratios of treatment effect were pretty similar at different core thresholds. So, they're fairly similar when you separate them out, but obviously the methodology is a little different between a CTP and a diffusion. And to Koji's point, he's absolutely right, the CTP has a tendency to slightly overestimate core when you compare to diffusion. Dr. Negar Asdaghi:         Yeah, and thank you. I think you already sort of alluded to what I was going to ask you and Koji, because, in reality, we have different ways of measuring core. We have the ASPECTS score, which is just a quick and dirty way of estimating or guesstimating core, and then we have CT perfusion, and we also have diffusion that sometimes is available to us, but not always. And the question is, in the heat of it, how we're going to measure the volume. With post-processing softwares, with CT perfusion, we get a quick potential ischemic core volume, but we don't have that capability with diffusion even if we did get diffusion. So, I think it's important to know that what Koji mentioned, an ASPECTS of eight can, more or less, in a quick fashion, be thought of as about 20 cc of core. And the other point that Koji raised was that CTP, again, this is sort of ballpark, can tend to overestimate ischemic core if you were to compare that with diffusion-weighted data. So, with that, now we have a study in which we have core volumes, and we're going to look at outcomes from endovascular thrombectomies compared to best medical management and see whether there is a correlation or interaction between ischemic core presentation, especially age. So, my next question would be to Andrew, can you walk us please through the main findings of the paper? Dr. Andrew Demchuk:   The whole goal of this paper was really to understand, are there thresholds in the older patients? When we looked at overall, and Bruce Campbell and the team wrote an important paper with HERMES and the CTP cohort overall, and the sort of message there was if you looked at shift analysis, there wasn't actually a core threshold found at all in HERMES for lack of benefit. There was a benefit across all the core volumes, but, of course, that's all ages. So, we were really interested in looking at the older patients because we felt there's more likelihood the core volume will matter in the elderly than in the younger patient. We know the younger population, it benefits overwhelmingly with EVT, it's hard to even find a core volume threshold. So, that was a premise. Essentially, we had 247 patients over 75 in the overall cohort, of which 98 had EVT. So, it was a decent population, and not a huge sample, but a decent sample. And so we looked at various things. The first thing that was interesting we found was that infarct volumes, the average infarct volume to achieve an mRS three or less, was lower in the older patients, significantly lower, was 23.9 for younger patients under 75 and 10.7 for the older patients. You tend to have much smaller infarcts to achieve good outcome. And so that was kind of interesting, and I think that's been shown by others. Then we got into the weeds to try to figure out, OK, what are these thresholds? And if there's one figure that matters, Negar, you know me to always point out that there's always one figure or table in a paper that's kind of where the money is, where the real learning is, and that's Figure 2 on this paper in my opinion, beautiful figure with four figure A, B, C, and D. And it really sort of nicely highlights these issues and these cutoffs. But what we saw is that in the older patients who received EVT, around 50 mils seemed to be a threshold to achieve zero three, you had to, to see treatment effect, you had to have a baseline infarct volume less than 50 mils for a zero three outcome advantage. For zero four, it was 85 mils. And then we looked at this issue of what we called futility, true futility. And that's a very controversial thing. What is futility, or how do you measure futility? And really, I think, we even had a debate about this as a HERMES group when we were designing the analysis, and we sort of landed on mRS five six. A 90% chance of mRS five six, right? That's quite the bar, right, to say true futility because some people argue mRS four is still not a horrible outcome. Culturally, that is an OK outcome in some situations. But when we did use that five six 90% threshold, it was 132 mils. So, you're getting up to these really large volumes. But here's the catcher in the whole thing, and Koji will probably speak to this a bit more. I don't want to steal his thunder too much, but this issue of reperfusion seemed to matter in this. And we'll come back to that maybe with another question. Reperfusion matters a lot when you think about these thresholds. Dr. Negar Asdaghi:         OK, so, Andrew, a lot of information, I don't know if I need a recap myself to recap, but basically what you mentioned is that for the older patients who received EVT, if we keep our eyes on the outcome of mRS of zero to three, it seems to be the magic core volume for that outcome post-endovascular therapy that it lands on the magic volume of 50 cc core. Did I get that right? Dr. Andrew Demchuk:   That's correct. Dr. Negar Asdaghi:         Then if you're still a bit more lenient with the definitions of what is favorable outcome, what outcomes we're looking at and so on, so forth, for an mRS of five to six, then when we talk about futility of endovascular thrombectomy, the volume that you mentioned, and again I want to ask you this, this volume is for elderly over the age of 75, is 130 mil. Dr. Andrew Demchuk:   132, but yeah, absolutely. But there's a real catcher here, and we need to really emphasize the catcher in this. Dr. Negar Asdaghi:         Okay. I will ask you one more question before I go to Koji, which I'm sure is going to tell us more about that catcher. Andrew, can you please tell us about the factor of time? I feel like that is something that we need to discuss, as well. Your study included patients early on in their stroke onset, but we're talking about an important interaction. The question is, do you think the results of this interaction would be different or impacted by the value of time? Dr. Andrew Demchuk:   Hypothetically? It must, right? I think that that must be the case. We don't have any data specific to this. That would be an interesting Aurora analysis to do. Now, of course, the challenge with late window analysis is, we are really small core in our late window trials, we probably have even a much smaller proportion of large cores. So, to be able to even tackle that question in the late window is, I don't know if we have the data yet, to be honest. But it makes sense that you would expect the thresholds to be a bit lower the later you are in the window. But that is a hypothetical opinion. Dr. Negar Asdaghi:         Right, so, I want to take that and come to Koji. I want to digress a little bit to Koji and see how we can understand the finding of this current analysis of this paper. So, small core patients early on into their onset, we're looking at the interaction between age and their core volume and coming up with numbers 50 cc for the elderly population. If you're looking at the outcome of zero to three or 132, as Andrew pointed out, for an MRS of much higher, four or five. Dr. Andrew Demchuk:   Actually five, six, 90% chance of five, six. So, it's there. It's like almost everybody got five, six, took 132 mils to get there. So, it's like this extreme outcome. Dr. Negar Asdaghi:         Right, so, exactly, and I have to correct it, again, mRS of five or six or dead or almost dead mRS basically. Dr. Andrew Demchuk:   In 90% of patients. Dr. Negar Asdaghi:         90% of patients. So, we have these important numbers here, and I want us to basically understand these numbers in these volumes in the context of the recently published RESCUE-Japan LIMIT study. Can you tell us a little bit about that study and how we can make sense of these volumes in the setting of that paper? Dr. Koji Tanaka:               In the recent RESCUE-Japan LIMIT trial, the median ASPECTS was lower, and baseline ischemic core volume was greater than those in our study. And surprisingly, the median ischemic core volume in that trial was close to our threshold to predict less than 10% of patients achieve a modified Rankin Scale of four or less after endovascular therapy. We thought this is due to much higher complete reperfusion rate in HERMES patient. We have much interest in their additional analysis for outcomes in elderly patients by reperfusion status. This potential benefit of endovascular therapy in the area is promising for the future clinical trials. Dr. Andrew Demchuk:   I think just to add to that, it was actually really interesting, Negar, because when we were analyzing all of this and then the trial came up and it was actually really nice because we're like, OK, how does our data relate to their data? And that's where Table 2 comes in, and it would almost be worth putting on the pod, whatever, I don't know if you have on your podcast website, you have one figure that you can sit there with as you listen to the podcast, because that would be the figure. Dr. Negar Asdaghi:         We'll work on that Andrew, but tell us a little bit more because, really, when I read the trial results, the way I understand it is that people enrolled in RESCUE-Japan that were older than 75, and these are all large core patients, benefited more from endovascular therapy than their younger counterpart. How do I understand that? I don't know how to wrap my head around that finding. Dr. Andrew Demchuk:   You want to try to answer that, and then I'll add? Dr. Koji Tanaka:               As I mentioned previously, we want to know about the exact patient population just only for elderly patients, whether they have a exactly larger ischemic core volume or as well as their functional outcome. How many patients achieved modified Rankin Scale four or less or three or less, or more than five or six? Dr. Andrew Demchuk:   Koji's point's very important. We actually don't have the breakdown of the mRS, so we don't know if they created a lot of fours, or threes, or what. So, that's one issue. But I think that the key to this whole thing is to understand that this is a 2022 trial. HERMES data is essentially a 2015 equivalent where we're looking at a number of clinical trials who roughly ended between 2014, 2016. So, the technology, the technique, the operators, are just at a different level back then than now. And quite frankly, EVT is an improving treatment. We probably don't even fully understand how much, I mean, we're just getting better at it. And I think what's happened here is the reperfusion rates have improved. And our HERMES reperfusion rates, remind me, Koji, I think they're about half, we think, in HERMES, than like the TICI 2bs, threes, are half in HERMES what they got in RESCUE-Japan LIMIT. So, when you achieve successful reperfusion, what were the numbers here? TICI 3 was 43% in the Japan RESCUE LIMIT, and 8.6% in HERMES. Okay, TICI 3s were not ... Now that may be slight differences in core lab interpretation, but we were just starting to get good at 3s. We were getting a lot of 2bs and some 2cs, but we weren't getting a massive number of 3s back in 2015. Well, voilà, now we are, right? We're hitting home runs when we didn't before. And I think that has really shifted the goalposts on the large core. If you open the vessel, they can still do well if they're elderly, but you've got to really open that vessel. And in HERMES, we only did that in a small portion of patients. So, these thresholds are sort of representative of 2015 skill. Dr. Negar Asdaghi:         Golden points, Andrew and Koji, both of you. I want to recap what you mentioned here. A note to all of our audience and listeners that we are looking at an analysis with RESCUE-Japan, an analysis of a 2022 study. And the patient population that were enrolled were also treated much later in terms of time than the patient population that was enrolled in the HERMES collaboration and in all of the trials that contributed to HERMES. So, we've got to remember that EVT is this fluid, ongoing, everyday-improving therapy, from our techniques to everything else, you know, how fast we get patients to the angiosuite. And the point that you raise, I want to repeat that, the percentage or the odds of achieving a perfect reperfusion was, in RESCUE-Japan, was 43% odds of TICI 3 reperfusion, whereas only 8.6%. So, when we're talking about all of these predictive modeling or predictive factors that will tell us who's going to do well, who's not going to do well, it also is predicated on the angiographic success. And perhaps in the earlier trials or even the early study that we covered as part of the STRATIS registry, we put everybody, TICI 3s with TICI 2b or better, whereas nowadays we accept the best, TICI 3s, and maybe that improved percentage in the most recent trial, the RESCUE-Japan, really did what it had to be done for the elderly population to keep that in mind. And Andrew, before we end our interview, I want us to get your top two takeaway messages from this paper. Dr. Andrew Demchuk:   Clearly, elderly patients do better when their strokes are smaller, that we know, compared to younger patients. But it's all about hitting the home run. It's all about hitting the home run. Figure 2C and 2D, you can see that if you achieve that high TICI score, a significant proportion of elderly patients potentially could still benefit, 30–40% reasonable outcomes with bigger cores if you get those high TICI scores. So, it is about hitting the home run in reperfusion in the elderly. You need to go for it, and hopefully you're successful, because if reperfusion isn't successful, then generally the outcomes are not ideal and they certainly worsen as the core volumes become larger, bigger. Dr. Negar Asdaghi:         Before I ended the interview, given Andrew's tremendous experience as a longtime fellowship director and seeing that he was flanked by two of his fellows, one past, myself, and one present, Koji, I had to ask him one final question of what his philosophy is as an educator. Dr. Andrew Demchuk:   I have a sort of philosophy on life with fellows. I always look for the special power in a fellow. I realized a long time ago we're all, we're not perfect, nobody's perfect, I'm not perfect, but there's usually a special power in people, and if you spend the time to get to know them, you identify that special power, and you really help harness it because you know that if they can harness it when they go back to their faculty job, they're going to really contribute something special to their team, right? You can imagine six special powers from six different people in a team. Now you've got a real team, right? If you know what your power is, you know your limitations, but you know where your strengths you can add to the group, and that's what we try to do here when we can. It's not always, you know, special powers, you have to kind of seek them out. But they're there in most people, and that's really important for career down the line. Dr. Negar Asdaghi:         And this concludes our podcast for the December 2022 issue of Stroke. Please be sure to check out this month's table of contents for the full list of publications, including our very interesting Stroke Images series. In this month, we have a case of progressive cervical myelopathy secondary to a dural AV fistula supplied by the anterior inferior cerebellar artery. We also have a separate case of carotid rete mirabile imaged with a four-dimensional flow MRI study. And with these cases, we bring our 2022 Stroke Alert Podcast series to an end. Over the past 12 months, we've ended our podcasts with various inspirational tales. From the moving account of the American runner Steve Prefontaine and the remarkable journey of the Syrian refugee and Olympian swimmer Yusra Mardini, to the discovery of positron and Commander Armstrong's landing on the moon, our podcast stories have but one thing in common, which is the story of human perseverance and consistency in the face of hardship. So, as we end 2022 to start 2023 anew, Andrew's comments on finding that special power in each of us resonate with our resolution to stay alert with Stroke Alert. This program is copyright of the American Heart Association, 2022. The opinions expressed by speakers in this podcast are their own and not necessarily those of the editors or of the American Heart Association. For more, visit AHAjournals.org.

Swim Swam sat down with Yusra Mardini, the Syrian Refugee that has swam at 2 Olympic games (Rio, Tokyo) as a member of the Olympic Refugee team. Mardini and her sister, Sara, are the subjects of the #1 Netflix movie "The Swimmers", which tells the story of the two crossing the Agean Sea from Turkey to Greece with 18 other refugees in a raft that is meant to hold 6-7.   Mardini discusses the boat trip, making and promoting "The Swimmers", and what her life looks like now after 2 Olympic Games. The now-German citizen is attending film school at the University of Southern California and swimming just for fun.

In this episode I interview Nathalie Issa, the star of the Netflix film The Swimmers.Nathalie plays the part of Yusra Mardini who is training to be an Olympian swimmer in Syria when she has to flee the coutry with her sister and cousin. What follows (in this true story) is their journey as refugees which includes swimming a sinking boat of fellow refugees to safety in the sea.The film is exceptional in the way that it humanises refugees and Nathalie's performance is breathtaking.During the episode we chat about how Nathalie had to face one of her biggest fears to take on the role, filming with her sister, how she conveyed Yusra so authentically and we chat about Nathalie's own story which involves leaving Lebanon for a life in France.Later we chat about Nathalie's views on beauty and what it means to her. I adored getting to know Nathalie. She is so incredibly honest and authentic and I think you'll her find her story and views on beauty fascinating.

Sally El Hosaini joins Anna Smith to discuss her new film The Swimmers and to talk in-depth about compassion and empathy in her work, her filmmaking as a political act, and her journey to become a director. Anna also speaks with the stars of the film, real-life siblings, Nathalie and Manal Issa, as well as one of the women who inspired the film, Yusra Mardini. They talk about their shared experience of being displaced from their homes, and the special relationship between sisters. Based on a true story, The Swimmers follows sisters Yusra and Sara Mardini from their war-torn Syrian home via Germany to the 2016 Rio Olympics. Over the course of their harrowing journey as refugees they put their skills as champion swimmers to heroic use, and this becomes their saving grace. The girls' story is an uplifting and inspiring look at sisterhood, compassion, bravery and the refugee experience. There's also a postscript to the film: Sara Mardini is now a humanitarian worker who has been helping refugees in Greece. She has been charged with people smuggling - her trial is currently on hold: https://www.amnesty.org/en/latest/news/2021/11/sean-binder-and-sarah-mardinis-lives-remain-on-hold-as-trial-is-adjourned/ The Swimmers is in select UK cinemas now and will be available globally on Netflix from 23rd November. For more information on refugees, and on some of the charities that aid those who are displaced, click the below links: www.amnesty.org.uk www.refugee-action.org.uk www.actionaid.org.uk www.unicef.org.uk Other films mentioned in this episode include: My Brother The Devil, Sally El Hosaini, 2012 Become a patron of Girls On Film on Patreon here: www.patreon.com/girlsonfilmpodcast Follow us on socials: www.instagram.com/girlsonfilm_podcast/ www.facebook.com/girlsonfilmpodcast www.twitter.com/GirlsOnFilm_Pod www.twitter.com/annasmithjourno Watch Girls On Film on the BFI's YouTube channel: www.youtube.com/playlist?list=PLX…L89QKZsN5Tgr3vn7z Girls On Film is an HLA production. Host: Anna Smith Executive Producer: Hedda Archbold Producer: Lydia Scott Audio Producer: Elliana Jay Harmer Intern: Ellie Hardy House band: MX Tyrants This episode is in partnership with The Swimmers

This special episode is a reminder, in the face of so much hateful rhetoric from government officials, that refugees need our allyship, not our prejudice. Today we are joined by one of the most inspirational people I have ever met, Yusra Mardini who has overcome what are unimaginable obstacles for most of us, but which are daily obstacles for so many fleeing prejudice and war the world over. In March 2011 when civil war broke out in Syria, Yusra - trained by her father - had dreams of becoming an Olympic swimmer. But by August 2015 she and her sister, Sarah had no choice but to leave their family behind and undertake a journey which no one should have to. Their perilous journey to Europe saw the sisters fly to Istanbul before paying human traffickers to take them to Greece, and overland to Germany. What occurred in the sea en route to Greece is beyond harrowing. With 18 people on board, the dingy started to sink and for three hours Yusra and Sarah had no option but to swim alongside the boat. Not only did Yusra make it to Germany, but after finding a new coach, she signed up to represent the refugee team at the 2016 Rio Olympics; a true testament to human determination. She went on to carry the Olympic flag for the Refugee team at the opening ceremony of the Tokyo Olympics and has since been named a UNHCR Goodwill Ambassador to help spread awareness of the plight of refugees. It's no wonder the Mardini sister's story has now been made into one of the most moving films I have ever seen, The Swimmers, which is now available on Netflix.The Swimmers is a timely story everyone needs to watch and even more pressing when you consider Sarah Mardini could be facing decades in prison after returning to Lebos to help vulnerable people arriving on Greek shores. I hope you find this powerful conversation with Yusra just as inspiring as I did and if you do want to find out more about how you can help refugees the world over please visit choose.love. I also hope you keep on listening and finding the power to Reign in your own lives, too. If you love this episode, please get in touch (follow me across social media @joshsmithhosts), I love hearing from you. Love, Josh xxx

Poet Joelle Taylor won the Polari Prize last night and the TS Eliot Prize in January this year. Over a long career as a writer for the page and the stage she has explored butch lesbian counterculture and told the stories of the women in underground communities fighting for the right to be themselves. She joins Emma Barnett to explain how joining the literary establishment fits with a lifetime of protest. As Deputy Prime Minister and Justice Minister Dominic Raab stands in for Prime Minister's Questions today, despite accusations of bullying, we look at how MPs and the macho culture of Westminster can be called to account without an ethics advisor, since Lord Geidt resigned earlier this year. Emma speaks to Pippa Crerar political editor of The Guardian and Christine Jardine, Liberal Democrat MP Edinburgh West, spokesperson for Cabinet Office, Women and Equalities and Scotland, who yesterday tabled a bill asking for parliament to appoint an ethics advisor if the conservative party fails to do so. We speak to director Sally El Hosaini about her new film The Swimmers which is based on the true story two Syrian sisters who fled Damascus in a dinghy boat in order to escape war and build a new life for themselves. One of those sisters, Yusra Mardini, will also be speaking to Emma Barnett about how she feels about her story being turned into a film. Fantasy Football is a hugely popular online game which requires building a make believe team of real world players who compete in the Premier League. But the growth of women managers has exceeded that of men in the last five years, rising by 112%. With the Premier League taking a break for the first ever winter World Cup, we explore the challenges early female participants of Fantasy Football have faced and what their participation in the game, and a growing interest in football, could have on the sport.

On Episode 14 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the March 2022 issue of Stroke: “Natural Course of Cerebral Cavernous Malformations in Children” and “Direct Oral Anticoagulants Versus Warfarin in Cerebral Venous Thrombosis (ACTION-CVT).” She also interviews Dr. Mohammad Anadani about his article “Magnitude of Blood Pressure Change After Endovascular Therapy and Outcomes.” Dr. Negar Asdaghi:                        1) Are direct oral anticoagulants a reasonable alternative to warfarin for treatments of patients with cerebral venous thrombosis? 2) What are the predictors of first and recurrent intracerebral hemorrhage in patients with cerebral cavernous malformation? 3) Is there an optimal blood pressure target after successful endovascular thrombectomy? We have the answers and much more in today's podcast. This is the latest in Stroke. Stay with us. Dr. Negar Asdaghi:                        Welcome to another incredibly informing Stroke Alert Podcast. My name is Negar Asdaghi. I'm an Associate Professor of Neurology at the University of Miami Miller School of Medicine and your host for the monthly Stroke Alert Podcast. The March 2022 issue of Stroke includes a number of papers published in conjunction with their oral presentation at the International Stroke Conference in New Orleans, from contemporary trends in the nationwide incidence of primary intracerebral hemorrhage, to disparities in Internet use among U.S. stroke survivors' implication for telerehabilitation during COVID-19 and beyond. I encourage you to review these timely topics in addition to listening to our podcast today. Later, in our interview section, I discussed the optimal blood pressure goal after endovascular therapy and the results of a subgroup analysis of the BP-TARGET randomized trials with Dr. Mohammad Anadani from the Department of Neurology at Washington University in St. Louis. But first with these two articles. Dr. Negar Asdaghi:                        Cerebral cavernous malformations, also referred to as cavernous angiomas, cavernomas, cav mals, or CCMs, are angiographically occult, low flow, vascular lesions with no large arterial inflow or venous outflow vessels. These are clusters of dilated sinusoidal vascular channels that are aligned by a single layer of endothelium without the normal surrounding vascular smooth muscles, and they lack the normal tight junctions between their endothelial cells. Cavernomas can be found in both children and adults. So, the question is, how do these lesions present, especially in children, and what is their natural course? Now, before we answer these questions, let's review a few important points about cavernomas and what is known about these lesions in the literature. Number one, cavernomas are acquired lesions. Although initially thought to be congenital, they're now known to be acquired as comparing by many reports of patients with normal MRI findings, who later developed a CCM. Number two, they're not always benign. While most of them can have a benign course, cerebral cavernomas can be a cause for headaches, seizure disorders and intracerebral hemorrhage, which is, of course, their most feared complication. Dr. Negar Asdaghi:                        Number three, though CCMs are rare vascular disorders with a prevalence of 0.6% in children and young adults, about a quarter of patients with a confirmed diagnosis of cerebral cavernous malformation are under the age of 18. And number four and finally, data seem to suggest that the risk of hemorrhage is potentially higher in the pediatric population than their adult counterparts. So, determining the natural course of CCMs and predictors of intracerebral hemorrhage is important for all patients, but especially important in the pediatric population. Now, in the current issue of the journal, in the paper titled "Natural Course of Cerebral Cavernous Malformations in Children: A Five-Year Follow-Up Study," a German group of investigators led by Dr. Alejandro Santos from the Department of Neurosurgery and Spine Surgery at University Hospital in Essen and colleagues studied the clinical presentation and predictors of intracerebral hemorrhage in their pediatric population over a 17-year study period. Dr. Negar Asdaghi:                        So, they identified 129 patients with a diagnosis of cerebral cavernous malformation that had baseline MRI imaging completed and at least one or more follow-ups during the study period. Now, some of these patients were treated surgically and some conservatively in the study. The mean age of their study was 10, and over 50% of their study population was male. Developmental venous anomalies, or DVAs, were detected in 15% of their study population, and 20% had brain stem cavernoma localization. Now, importantly, half of these kids, so that's 55.8% of their study population, presented with an intracerebral hemorrhage, and that's how their cavernomas were diagnosed. So, what were their top three findings? Dr. Negar Asdaghi:                        Number one, on the comparison of conservatively treated patients to those treated surgically, which was 37% of their cohort, they found that overall these two groups had comparable clinical characteristics and demographics with regards to sex, age, multiplicity of cavernomas, brain stem location, and family history of their lesions. But not surprisingly, those who were surgically treated were more likely to have presented with an intracerebral hemorrhage and less likely to be asymptomatic, meaning that their cavernoma was not an incidental finding as compared to those who were conservatively treated. Dr. Negar Asdaghi:                        Number two, when they looked at predictors of presentation with intracerebral hemorrhage, they found that family history of cavernomas and brain stem cavernomas were significant predictors of presenting intracerebral hemorrhage. Number three, when they excluded those who underwent surgery, the annual risk of hemorrhage for the overall untreated participants was 4.1%. However, we should note that this rate significantly varied based on certain characteristics of the patients. The risk of hemorrhage, or rather the risk of re-hemorrhage, was double this baseline, that is 8.1%, for those cavernomas that presented with a bleed at presentation. The annual rate of hemorrhage was equally high at 7.1% for brain stem cavernomas, and then this rate gradually declined for familial form cavernomas at 6.2% annual risk of hemorrhage and multiple cavernomas at 4.8%. And it went all the way down to 0.4% annual risk of hemorrhage for asymptomatic incidentally found cerebral cavernomas. So, in the multivariate analysis, presentation with an ICH remained an independent predictor of re-hemorrhage and cavernomas with a high hazard ratio of 14. That is 14-fold higher risk of hemorrhage in cavernomas that present with a bleed as compared to those that did not. Dr. Negar Asdaghi:                        Now, finally, on the association between DVAs and risk of hemorrhage, this study showed a possible reduced risk of hemorrhage in cavernomas that had associated DVAs, but this was not a statistically significant association. It is important to note that this finding is in keeping with the published studies in the adult population, but in contrast to the previously published data in the pediatric population. So, this association between presence of a developmental venous anomaly and cavernomas and the risk of subsequent hemorrhage needs to be furthered studied. So, what did we learn from this study? Pediatric patients with brain stem cavernomas and familial cavernomas have a higher risk of intracerebral hemorrhage as mode of presentation. The risk of re-hemorrhage is 14 times higher in cavernomas that present with an ICH as compared to cavernomas that did not bleed. And the probability of bleed tends to increase over time. Dr. Negar Asdaghi:                        Cerebral venous sinus thrombosis, or CVST, refers to thrombosis in the dural venous sinuses, cortical veins, deep cerebral veins, or a combination of these venous structures. CVST is an uncommon cause of stroke accounting for overall 1% of all strokes and can cause venous ischemic infarcts or intracerebral hemorrhage and importantly has a high morbidity and mortality if unrecognized and left untreated. Anticoagulation is generally the mainstay of therapy for CVST, which needs to be initiated as soon as possible, even in the presence of hemorrhage in the brain. The data regarding the choice of anticoagulation in CVST is generally extrapolated from randomized studies completed in patients with systemic venous thromboembolism, so conditions such as pulmonary emboli or deep venous thrombosis, and indicate that direct oral anticoagulants, or DOACs, are viable alternatives to traditional warfarin therapy in this patient population. This question was specifically studied in the RESPECT-CVT trial, which was a small European randomized trial that included 120 patients with cerebral vein thrombosis, randomized to either receiving dose adjusted warfarin or dabigatran at 150 milligram BID. Dr. Negar Asdaghi:                        The results of the study was published in JAMA Neurology in 2019 and showed that CVST patients treated with either dabigatran or warfarin were at low risk of recurrent venous thromboembolism, and they also showed a comparable safety profile in terms of risk of hemorrhage or mortality in patients treated with DOAC as compared to warfarin. But how do DOACs perform as compared to warfarin in routine practice is unknown. So, in this issue of the journal, in the study titled, "Direct Oral Anticoagulants Versus Warfarin in Cerebral Venous Thrombosis (ACTION-CVT): A Multicenter International Study," the ACTION-CVT investigators, led by Dr. Shadi Yaghi from the Department of Neurology at Brown University, aimed to compare the safety profile of DOACs to that of warfarin, in a multicenter international study that included 1025 imaging-confirmed CVST patients from multiple centers in the United States, Italy, Switzerland, and New Zealand. Dr. Negar Asdaghi:                        They had a number of exclusion criteria for this study, excluding patients with active cancer, those with a confirmed history of antiphospholipid antibody syndrome and those who were not treated with an oral anticoagulant. And after excluding these patients, it gave them their study sample of 845 CVST patients. So, what were their main findings? Number one, in keeping with a prior literature on CVST, these patients were young, their mean age was 44, and majority of them were women, so that was 67% of their cohort. And they found that a third of these patients were actually treated with a DOAC, and, in addition, another 15% received a DOAC at some times during their treatment course. Finding number two, the most common DOAC used in this population was apixaban, that was 66% of cases treated with a direct oral anticoagulant, followed by rivaroxaban in 18% of cases, and then dabigatran used in 13.5% of DOAC-treated cases. Dr. Negar Asdaghi:                        Important finding number three. A total of 27 patients had recurrent CVST, which also included patients with progression of their cerebral vein thrombosis on follow-up vascular imaging, and 17 patients had recurrent venous thromboembolism, and two had both. So, during their mean follow-up of 345 days, they had the rate of 5.68 recurrent venous thrombosis per 100 patient years. These rates were not different for DOAC-treated versus warfarin-treated patients in both unadjusted and adjusted models. Now, very important finding number four. When they looked at the rate of recanalization on follow-up imaging, for those in whom this information was available, partial or complete recanalization occurred in 86% of DOAC-treated patients versus 84% of warfarin-treated patients. This was not a statistically significant difference in the unadjusted or the adjusted models. Recanalization is, of course, an important determinant of outcomes in CVST and should be noted that recanalization is, of course, an important determinant of outcomes in CVST since persistent thrombosis through chronic raised ICP can potentially lead to a variety of neurological morbidities, such as chronic headache, chronic papilledema and increased risk of development of dural AV fistulas. Dr. Negar Asdaghi:                        Now, finally, in terms of safety profile, they had 31 hemorrhages, 23 intracranial, majority were symptomatic and 9 extracranial hemorrhages. The hazard ratio for hemorrhage or death was similar for DOAC- and warfarin-treated patients, again in the unadjusted and adjusted models. So, bottom line, in this large international cohort of patients with CVST treated with an oral anticoagulant in routine practice, patients treated with DOACs had similar clinical and radiographic outcomes and had a similar favorable safety profile when compared to those treated with warfarin. So, we stay tuned for the results of the ongoing randomized trials on this subject. Dr. Negar Asdaghi:                        What is the optimal blood pressure target after endovascular therapy? This is a commonly encountered question in routine clinical practice with a not-so-straightforward and easy answer. After a successful endovascular treatment, high systolic blood pressure targets are thought to be associated with increased risk of reperfusion injury and development of intraparenchymal hemorrhage, leading to worsening of clinical outcomes. Conversely, low blood pressure targets may worsen the ischemic penumbra, especially in the setting of incomplete perfusion. The current stroke guidelines recommendations regarding blood pressure control after endovascular treatment are mostly extrapolated from the post-thrombolysis studies. The BP-TARGET trial was a recently completed randomized study in France that aimed to assess the safety and efficacy of intensive blood pressure lowering, that is systolic blood pressure of less than 130, as compared to standard of care, that is systolic blood pressure between 130 to 185, after successful endovascular therapy in acute ischemic stroke. Dr. Negar Asdaghi:                        This was a neutral study, and the main results of the trial was published in early 2021 in Lancet Neurology. And if you missed it, well, as always, we're here with the Stroke Alert Podcast to fill in the gaps. So, we'll review the trial results with our podcast guest today, Dr. Mohammad Anadani, from the Department of Neurology at Washington University in St. Louis, who's also the first author of a paper in the current issue of the journal titled "Magnitude of Blood Pressure Change After Endovascular Therapy and Outcomes: Insight From the Blood Pressure-TARGET Trial." This was a post hoc analysis of the BP-TARGET trial, looking at the extent of blood pressure reduction and its implications of clinical outcomes. Welcome, Mohammad, thank you for joining us on the podcast today. Dr. Mohammad Anadani:            Thank you for having me. It's a pleasure to be here with you today. Dr. Negar Asdaghi:                        Thank you. So, blood pressure control is a really simple and yet extremely complicated topic when it comes to the collateral support before reperfusion therapies, and then, of course, the possibility of reperfusion injury post-thrombectomy in the setting of an ischemic stroke related to a large vessel occlusion. Can you please give our listeners an overview of the topic of blood pressure control in this setting? Dr. Mohammad Anadani:            Yes, absolutely. I totally agree. The topic of blood pressure control after, in patients with large vessel occlusion, is very complicated. And when we talk about blood pressure control, I think we should differentiate between pre-recanalization and post-recanalization. In the pre-recanalization period, the main focus should be to maintain adequate perfusion to ischemic penumbra to prevent infarct expansion. So, there is consensus that hypotension should be avoided at all costs pre-recanalization. When it comes to the post-reperfusion, here it gets a little bit more complicated. We do have a large body of evidence, as you mentioned, for the association between high blood pressure in the post-reperfusion period and the risk of poor outcome. What we don't know yet is if active reduction of blood pressure after reperfusion is beneficial. And that's why, as you mention, the American Heart Association guidelines just recommend a systolic blood pressure less than 180, just because of the lack of data to support the benefit of blood pressure reduction. Dr. Negar Asdaghi:                        Perfect. So, this was definitely the topic that the BP-TARGET trial set out to investigate. What is the optimal blood pressure target after successful revascularization therapy? Can you please tell us a little bit about the trial, the design and the inclusion criteria? Dr. Mohammad Anadani:            The Blood Pressure-TARGET trial, or BP-TARGET trial, aimed to assess the safety and efficacy of intensive blood pressure lowering treatment. The trial enrolled patients with anterior circulation large vessel occlusion, that is M1 or ICA occlusion, or tandem occlusion, which is both M1 and ICA occlusion. The patients who were treated with endovascular therapy and achieved successful reperfusion, and they defined successful reperfusion as modified treatment cerebral ischemia 2b to 3. And then after enrollment, the patients were randomized in one-to-one ratio into intensive blood pressure control, which is systolic blood pressure less than 130, and standard blood pressure control, which is systolic blood pressure less than 185. Now, these two cutoffs came in from some evidence that systolic blood pressure less than 130 is beneficial in these patients or this is the optimal cutoff for patients with successful reperfusion. For the standard group, the design of the trial, at the time of the design of the trial, that was the standard or recommended European guidelines, blood pressure group. And the study was conducted in France between June 2017 and September 2019. Dr. Negar Asdaghi:                        Thank you, Mohammad. So, I want to recap for our listeners, we're looking at a French study that was conducted in four centers, in France. And it's a very recent study, recently completed. The whole thing was completed over the past five years. So, very interesting because it's applicable to our current treatment models. And these were patients with a large vessel occlusion in the anterior circulation that had undergone thrombectomy. All have achieved a successful revascularization, as you defined, TICI 2b or C or TICI 3, and then they were randomized to either standard of care in terms of post-thrombectomy blood pressure control or the intensive group, which was under systolic blood pressure of 130. Did I recap that correctly? Dr. Mohammad Anadani:            Correct. Dr. Negar Asdaghi:                        Perfect. So, now we're ready for the primary outcome. So, what was the primary outcome of the trial? Dr. Mohammad Anadani:            The primary outcome was any radiographic intraparenchymal hemorrhage that was seen on CT within 24 hours to 36 hours after successful reperfusion. Dr. Negar Asdaghi:                        This is interesting, Mohammad, this is a different primary outcome than we're used to in a usual randomized trial that commonly uses a modified Rankin scale of usually at 90 days. Do you have any insight as to why a radiographic outcome was chosen for this particular study, and obviously what would be fine as part of the trial? Dr. Mohammad Anadani:            Yes. So, the main reason why the study investigator chose this as a primary outcome was because really the benefit of, or at least what is thought to be the benefit from systolic blood pressure reduction, is to lower intraparenchymal hemorrhage or the risk of intraparenchymal hemorrhage. So, to assist the efficacy of this intensive blood pressure lowering, the first thing we expect to see is lower intraparenchymal hemorrhage. So, when you have your target as intraparenchymal hemorrhage, it truly requires much smaller sample size than having functional outcome as the primary outcome. Dr. Negar Asdaghi:                        Okay, perfect. And I think we're ready to hear the results for the main BP-TARGET trial. Dr. Mohammad Anadani:            The results of the trial were disappointing for people who were interested in this topic. The primary outcome, which, again, was an intraparenchymal hemorrhage, occurred in 42% of patient intensive arm and 43% of patient the standard arm. And there was no difference in the risk of intraparenchymal hemorrhage between the two groups. Dr. Negar Asdaghi:                        Well, I think you can phrase it as disappointing, or more room to understand the pathophysiology and also onto bigger and better trials. And so I want to now move on the current paper in this issue of the journal, which is a post hoc analysis of the trial. Can you tell us a little more about your study? Dr. Mohammad Anadani:            In our study, we wanted to study the blood pressure as dynamic target. So, we wanted to see if there is any association between blood pressure change from baseline with the functional and safety outcome after endovascular therapy. And also we wanted to understand the shape of the association. In other words, to see, is there a point after which the blood pressure reduction becomes helpful? So, to do that, we did this post hoc analysis of the BP-TARGET trial, and we only enrolled patients who had more than 50% of planned blood pressure measurements. And then we defined systolic blood pressure change as the difference in the mean achieved blood pressure in three different time points: zero to one hour, one to six hours, and six to 24 hours minus the baseline systolic blood pressure. And here we considered the end-of-procedure blood pressure as the baseline systolic blood pressure. Dr. Negar Asdaghi:                        All right. So, I want to recap what you mentioned before we hear what you found in the study. So, really, blood pressure, as you noted, is a dynamic factor. It's not just a target, but other words, is how fast you're reducing it, in what timeframe after endovascular thrombectomy, and also how much. So, as an example, as we were discussing this earlier, before we did the podcast recording, is if you started a systolic blood pressure at 190 and then reduced that patient quickly to 130, is that the same as if starting blood pressure was 150, and then you reduce it to, again, 130? So, delta, or the magnitude of change in blood pressure, and also time intervals, that how long after thrombectomy you were able to reduce that blood pressure, are all important factors in terms of determining the outcome. That's a nice summary of what this current study aimed to do. Perfect. So, with that, we're ready to hear the results of your study. Dr. Mohammad Anadani:            We included 267 patients, 137 in the intensive arm and 130 patients in the standard arm. And then, when we compared patients who had poor outcome at 90 days to patients who had good outcome at 90 days, we found that the patient who had poor outcome had less systolic pressure reduction, meaning these patients had less systolic pressure reduction compared to the baseline than the patient who had good outcome. And then, when we controlled for other confounders, their association remained significant, especially for the one- to six-hour period and six- to 24-hour period. And the same results were when we had our outcome as intraparenchymal hemorrhage, we found the same results. The patient who had intraparenchymal hemorrhage had less systolic blood pressure reduction than patients who did not have intraparenchymal hemorrhage. And, again, the association remained significant even after we adjusted for possible confounders, like age, the degree of recanalization, and the stroke severity. Dr. Mohammad Anadani:            And then we wanted to see, if we looked at the blood pressure change as categorical variable, meaning we want to see if there is a difference between large systolic blood pressure reduction compared to minimum or no systolic blood pressure reduction. So, we divided the systolic blood pressure reduction into three categories: the minimal, which was just zero to 10 systolic blood pressure reduction; the moderate, which was 10 to 20; and large, which was more than 20 millimeter mercury systolic blood pressure reduction. And when we looked at that, a patient who had more than 20 millimeter mercury systolic blood pressure reduction had significantly lower risk of poor outcome than patients who had no systolic blood pressure reduction or just minimal systolic blood pressure reduction. And the difference was striking. There were the patients who had more than 20 systolic blood pressure reduction, they had almost 62% lower risk or lower odds of having poor outcome than a patient who did not have significant systolic blood pressure reduction. Dr. Negar Asdaghi:                        These are some very interesting findings. Let me try and to summarize this for our listeners and make sure that I understood the study results correctly. So, in other words, if we had a patient that at the end of a successful revascularization treatment, say, had a systolic blood pressure of 150, and that was reduced to 140, so there's a 10 millimeter mercury difference, that patient, in this particular study, had a higher risk for development of intracerebral hemorrhage than the person that finished at 180, so finished endovascular therapy at 180 millimeter of mercury. But then with rapid reduction, we dropped the blood pressure to, say, for example, 140, so that 40 millimeter of mercury of reduction carried a higher weight or higher impact on reduction of intracerebral hemorrhage than the absolute target of blood pressure, because your results did not look at which category were these patients under, were they under intensive category or standard, but they looked at just the magnitude of that drop, which showed a bigger implication on effective blood pressure reduction on outcomes. Dr. Mohammad Anadani:            Yeah, that is correct. Now, the primary outcome for our study and really what we want to look at here is the functional outcome, more than the intraparenchymal hemorrhage. And, like you said, if we have, let's say, patients who started with 160 and they dropped to 120 or started with 180 and they dropped to 150, these patients had better functional outcome than patients who started, let's say, with 160 and remained 160 or even their blood pressure increased after reperfusion. We did not look at absolute numbers, but we did look at if the patients were presented, let's say, above 180 or patient presented less than 180, and both of these patients had the same, or both of these groups had the same results, meaning systolic blood pressure seems to be beneficial for both of these patients. And also we looked at the patients who were in the standard arm or in the patients who were in the intensive arm, also both of them have the same results. The systolic blood pressure reduction remained associated with poor outcome. Dr. Negar Asdaghi:                        Mohammad, the current American Heart Association guidelines and also the European stroke guidelines both recommend a target systolic blood pressure of under 180 or 185 after successful recanalization. What do you think the optimal target blood pressure should be based on BP-TARGET trial and based on your post hoc analysis? Dr. Mohammad Anadani:            Yeah, that's a difficult question. We learn from the BP-TARGET trial, that's lowering systolic blood pressure is safe. And our study added to that, that significant reduction, especially in the first hour after reperfusion therapy, may be beneficial because patient had lower risk of poor outcome. However, I don't think we will have a one number that we will be able to say, this is the optimal blood pressure that fits all patients. I think the optimal blood pressure needs to be tailored to individual patient based on their admission blood pressure, based on their comorbidities, and also based on the degree of reperfusion. I don't think patients who have TICI 2b, for example, should be treated exactly the same as patients who had TICI 3. Dr. Negar Asdaghi:                        So, a lot still to come on this topic, and we are still learning. So, on that topic, can you tell us a little bit about the currently ongoing randomized trials on the topic of blood pressure controlled post-thrombectomy? Dr. Mohammad Anadani:            Yes. I think there are three main trials that are ongoing now and trying to assess the safety and efficacy also of intensive blood pressure reduction. The first trial is the Second Enhanced Control of Hypertension and Thrombectomy Stroke Study, or ENCHANTED2 study. And this study is being conducted now in China. And it's comparing systolic blood pressure less than 120 target to systolic blood pressure less than 180. And the study has the primary outcome here, is the shift in mRS score at 90 days. The study is estimated to be completed in 2023, so, hopefully next year, we will have some results. The second study is the Outcome in Patients Treated With Intraarterial Thrombectomy - optiMAL Blood Pressure Control, or OPTIMAL-BP. And this study is being conducted in South Korea, and it's comparing systolic blood pressure target of less than 140 to systolic blood pressure target of less than 180. Dr. Mohammad Anadani:            And the primary outcomes of this study are mRS zero to two at 90 days and symptomatic intracerebral hemorrhage. The study here is estimated to be completed in 2024. And the last trial is the Blood Pressure After Endovascular Stroke Therapy-II, or the BEST-II trial. And this is being conducted here in the U.S. and comparing three different blood pressure cohorts: less than 160 and less than 140 as the experimental group to less than 180 as the standard group. And the primary outcome of this study is final infarct volume. And also the co-primary outcome is utility-weighted mRS at 90 days. And this study is estimated to be completed next year, in 2023. Dr. Negar Asdaghi:                        So, a diverse group of randomized trials from Korea, China, and the United States. Hopefully, we'll have a lot more answers in the next two years then on this topic. So, just the last few minutes of our recording here. Mohammad, can you please summarize for our listeners, what should be our top two takeaway messages from your study and what we know from collectively in the field on the topic of blood pressure control post-thrombectomy? Dr. Mohammad Anadani:            I think the main home message that one, we found a leaner association between blood pressure change after endovascular therapy and poor functional outcome, and two, effective and significant systolic blood pressure reduction, which we defined in our study as a more than 20 millimeter mercury in the first hour after endovascular therapy, is potentially beneficial, and these patients had significantly lower risk of poor outcome than the patient who did not have significant blood pressure reduction. Dr. Negar Asdaghi:                        Thank you so much, Dr. Mohammad Anadani. Thank you for joining on the podcast today, and we look forward to having you back and covering more of your work in the future. Dr. Mohammad Anadani:            Thank you for having me, and I look forward to learning more about the Stroke studies from your podcast. Dr. Negar Asdaghi:                        Thank you. Dr. Negar Asdaghi:                        And this concludes our podcast for the March 2022 issue of Stroke. Please be sure to check out this month's table of contents for the full list of publications, including a series of Focused Updates on the topic of health equity and reduction of disparities in stroke, organized by Dr. Bruce Ovbiagele. It's hard to believe that we're already in March, and coming off the heels of one of our largest cerebrovascular annual meetings, the International Stroke Conference, which coincidentally concurrently happened with one of the biggest sports events of the year, the 2022 Winter Olympics in Beijing. Now, what do these two very different events have in common? Well, I think they both represent the extraordinary stories of talent and grit on the world stage. So, let's end our Stroke podcast with an inspirational story of the Olympian swimmer Yusra Mardini. Dr. Negar Asdaghi:                        In August 2015, after her family home was invaded and destroyed in the Syrian civil war, the 17-year-old Yusra and her sister, Sarah, fled Syria to Beirut, Istanbul, and finally İzmir, in Turkey, where they managed to squeeze onto a dingey crossing the Mediterranean to the Greek island of Lesbos. Carrying 20 people, rather than just six or seven, they found their boat sinking less than 30 minutes into their journey. Yusra, Sara, and another woman were the only ones on board who knew how to swim. Fighting for their life and that of the other refugees on board, they would swim the cold open water of the heavy seas for three and a half hours before reaching the shore. Less than a year later, Yusra became one of the top 10 athletes worldwide to qualify and compete in the 2016 Summer Olympics, as part of the first refugee Olympic athletes team. She won the opening heat of women 100-meter butterfly race, but did not make it to the podium in the Olympic Games. And that is, of course, only part of her story. Dr. Negar Asdaghi:                        Very much like the story of many scientists, doctors, engineers, and staff who make the international stroke meeting possible. Many stories are not celebrated on a podium, but nevertheless are the essence of the success of our stroke community. So, wherever you are in the field of neurosciences, whatever the challenge, and however cold the waters, know that while we don't share the same border, the same flag, or even a common language, together we push the field of cerebrovascular disorders forward. And, as always, we stay alert with Stroke Alert. Dr. Negar Asdaghi:         This program is copyright of the American Heart Association, 2022. The opinions expressed by speakers in this podcast are their own and not necessarily those of the editors or of the American Heart Association. For more, visit AHAjournals.org.

This is a special episode of our podcast with İlkay Gündoğan from Manchester City. We made this episode in collaboration with the UNHCR. That's the United Nations refugee agency. They help refugees all over the world and İlkay Gündoğan is one of their supporters.For this special episode İlkay Gündoğan did an interview with Yusra Mardini. She's an olympic swimmer and a former refugee from Syria. İlkay Gündoğan and Yusra Mardini scheduled a call, to shine light on what it's like to be a refugee. Because March is also women's month, they also talked about the women who inspire them in the world of sports and in their personal lives. - See acast.com/privacy for privacy and opt-out information.

The Olympics may be over, but August is still our Olympics month, and there is still some inspiration to be squeezed out of the Games.  Teresa starts off with the compelling story of the world's fastest blind man and his amazing running partner.  Then Teresa introduces us to a teenage refugee who risked her life fleeing from war-torn Syria, only to find herself become an Olympic swimmer.  Then Amy has two short stories of inspiring rowers.  One rower continues to row, despite his body failing him, becoming a para-athlete Olympic rower.  The second story is about two fun-loving boys who started doing a new rowing sport on a whim, and whim and now are heading off to compete internationally.   There is a quick question and answer session with Amy in dishing some answers.  Come have some fun, learn something new, and leave just a bit more inspired.We would love to hear from you.  Send us your comments or even your own inspirational stories at tangentialinspiration@gmail.com or give us your comments on our website, TangentialInspiration.com.Follow us on our social media:Website: https://tangentialinspiration.com/Instagram:  https://www.instagram.com/tangentialinspiration/Facebook:  https://www.facebook.com/pages/category/Podcast/Tangential-Inspiration-110449931124565/Twitter: https://twitter.com/TangentialInsp1

Die wohl persönlichste Folge ever! Gestatten, wir sind die alten Neuen. Ab sofort hört ihr jeden Sonntag Alex, Flo und André bei "Alles Ladde - Fundiertes Halbwissen" mit gewohnt spannenden Gedanken. Neuer Name, weiterhin high-quality Content! Für ein bisschen Namens-Nostalgie stellt uns Flo in der neuen Kategorie "der Random der Woche" eine spannende Persönlichkeit vor, die eigentlich viel bekannter sein müsste: Yusra Mardini. Außerdem beantworten wir eure Fragen zu unseren Personen. Wer sind denn eigentlich Alex, Flo und André? Wie kam Flo zum Fernsehen, wie konnte André 34.000 Euro verlieren und was lässt Alex Tränen über die Wangen laufen - das hört ihr in der ersten Folge von "Alles Ladde - Fundiertes Halbwissen". Folgt uns! Instagram: https://instagram.com/allesladde Twitter: https://twitter.com/allesladde Reddit: https://reddit.com/r/allesladde Wir bedanken uns beim "Museum für Popcorn" in Hamburg! Im neuen Content-Museum mit 23 Themensets sind unser Cover und viele weitere sexy Motive mit uns entstanden. Mehr dazu in der nächsten Folge und unter https://museumofpopcorn.de

On today's episode July 27th episode of the Just Talk Pod with George Jarjour we have our 3 course menu. For our appetizer George discussed Syrian refugee swimmer Yusra Mardini and her Germany from Syria to Tokyo for the Olympics. For our main course we talked about the Houston Texans crazy demands for Deshaun Watson. For our Desert George gives his Free Money play of the day brought to you by BetUs (use promo code "TheSportsOnTap" to get 125% bonus on your first deposit) which now 7-3 in July with a pending play.

Back again to put on a smile on that pretty face of yours! It's Squabbit! Glad to have you, glad to be back, and of course so glad to be sharing some positive news. On episode 55, we first learn about the two dozen goats that were set loose in a New York City park. For science. (05:48) Plus we chat about Jaylo Miles and his PTSD owl Louie. Together they combat mental health stigmas around PTSD and similar topics by building community and ... climbing literal mountains. (11:27) And last but not least, we cover the Olympic swimmer, Yusra Mardini. She is competing this year on The Refugee Olympic Team but there's many more layer to her story. (19:43) Sources: Goats in NYC Jaylo and his owls Yusra Mardini The Refugee Olympic Team Stay strong squad, love ya!

Guatemala, Síria e Bermudas estão unidos nos Jogos por três histórias de perseverança. Luis Grijalva, Yusra Mardini e Flora Duffy tinham tudo para não estar em Tóquio mas contrariaram as expectativas. See omnystudio.com/listener for privacy information.

#MenschenbeiAnnette #AnnetteRadüg #YusraMardini #FluchtausSyrien #SchwimmenbeiOlympia #SchlauchbootimMittelmeer #RADIO21 #RocklandRadio #AntenneSylt

Le podcast de WoW! News  - Écoutez l'article audio de la semaine  - Le 23 juillet prochain, la Syrienne Yusra Mardini défilera lors de la cérémonie d'ouverture des Jeux olympiques de Tokyo mais pas derrière le drapeau de son pays. La nageuse fait partie de l'équipe des 29 réfugiés, qui rassemble des athlètes ayant dû fuir leur pays. Sa participation à ces Jeux est le symbole d'une grande victoire.

What a powerful episode. This week I am joined by human rights lawyer extraordinaire, Alex Tarzikhan. We talk about privilege, refugees crossing from Turkey to Greece by sea, volunteering in Greece, the incredible story of Sara and Yusra Mardini, and refugee integration. You can stay up to date with all the cool initiatives she's working on by following @MeetARefugee on Instagram

เด็กน้อยที่ลี้ภัยออกนอกประเทศด้วยการข้ามน้ำข้ามทะเล แต่แล้วก็เกิดเหตุการณ์เรือเครื่องยนต์เสีย จนเธอต้องตัดสินใจกระโดดลงน้ำและว่ายน้ำพร้อมกับดันเรือยางที่ใช้ข้ามทะเล จนสุดท้ายเธอกลายเป็นนักกีฬาในสังกัดโอลิมปิกที่ไม่ขึ้นตรงกับชาติใด

Nadadora.

La increíble e inspiradora historia de una joven extraordinaria.En verano de 2015, Yusra, de diecisiete años, y su hermana mayor Sara huyeron de su casa en Siria arrasada por las bombas. Desde Damasco emprendieron un peligroso viaje hacia la costa de Turquía, donde consiguieron subir a un pequeño bote con otras veinte personas dispuestas a todo para llegar a Europa.Llevaban treinta minutos de travesía cuando el motor se detuvo y estuvieron a punto de volcar. En ese momento, Yusra, Sara y otras dos personas se tiraron al mar para aligerar la carga. Yusra y Sara eran las únicas que sabían nadar y durante más de tres horas fueron las que guiaron la barca hasta las costas de Lesbos, salvando la vida del resto de los pasajeros. En aquel momento nadie podía imaginar que un año después, Yusra Mardini competiría como nadadora en los Juegos Olímpicos de Río.

La historia de Yusra Mardini, una nadadora olímpica refugiada en Alemania debido a la guerra en Siria, quien estuvo a punto de morir en el Mar Egeo. Didier Drogba y cómo pudo él solo, utilizando su plataforma como jugador, unir a los rebeldes y al gobierno marfileño. ¡Qué lo disfrutes!

ضيفتنا لهذه الحلقة هي المنقذة و الناشطة الإنسانية و اللاجئة سارة مارديني التي سنتحدث معها عن قصة لجوئها مع أختها يسرى مارديني التي فيها تعطل القارب الذي كان سيوصلهما إلى جزيرة لسبوس في اليونان و اضطروا لسحب القارب لمدة ثلاث ساعات و نصف إلى بر الأمان. و بسبب نشاطها الانساني في اليونان ومساعدتها للاجئين هناك وجهت الحكومة اليونانية إليها أحكاما تتراوح مدتها حتى ٢٥ سنة واتهمتها بالإتجار بالبشر وتبيض الأموال وغيرها. وستخبرنا أيضا عن التحديات التي تواجهها وعن تجربتها في العمل التطوعي لمساعدة اللاجئين على الشواطئ اليونانية والكفاح من أجل حريتها، وغيرها من المواضيع الشيقة. In this episode, we talk to human rights worker, professional swimmer, and refugee Sarah Mardini. We discuss her story since arriving on the shores of Lesbos after almost drowning in the overcrowded dinghy and swimming the boat with her sister Yusra Mardini for 3.5 hours to safety. Sarah, who is now facing a prison sentence of up to 25 years and being accused of several crimes, such as people smuggling, espionage and money laundering, talks about the criminalisation of social workers, her experience volunteering to help the Refugees on the Greek shores, battling for her freedom against false accusations, and much more. Contact: Instagram: https://instagram.com/sarahmardini_x?igshid=1m4x0epfpqml6 Shore: https://www.instagram.com/shore_bcb/?igshid=1jqxyn1y57mw2 All the show notes can be found on the website. Don't forget to subscribe and leave some feedback! ________ You can find Leen Al Kalaam Podcast on يمكنكم الاستماع أو تحميل حلقات البودكاست عن طريق – iTunes – Google Podcasts – SoundCloud – YouTube – Spotify or at www.leenalkalaam.com

Lately I've spent some time with my kids looking at a globe, "if you fly over it, can you see the border?" they ask. No. These are lines drawn by man. Man argues, wars, and discriminates over lines, I tell them. As today's guest, Melinda Menzer says, "you can't fence in the water", and she loves swimming across those silly lines that are drawn on maps. To demonstrate the fluidity of borders, Melinda swam from the US to Mexico and back last year, in the process raising over $10,000 for HIAS, the world's oldest refugee agency. I loved hearing Melinda's story for so many reasons, I hope you do to - please enjoy this episode!In her own words: Melinda Menzer is a long-distance open water swimmer and the swimmer behind Swim for HIAS, a project to raise money and awareness for HIAS, the world's oldest refugee agency. Melinda began swimming as a child but picked up open water swimming as an adult in 2011. She has swum some of the major American events, including Swim the Suck and SCAR. A few years ago, she decided to put her love for swimming to work for her commitment to the United States' historic role as a sanctuary for refugees and asylum seekers. In November 2019, she swam 10.2 miles across Amistad Reservoir on the Texas/Mexico border, crossing from the U.S. to Mexico and back; she raised over $10,000 for HIAS while making real the idea that borders are fluid. She is inspired by other great swimmers such as Lynne Cox and Yusra Mardini, who have swum across borders to bring people together in freedom.If you'd like to be a guest on Marathon Swim Stories, mailto:shannon@intrepidwater.comStay in touch by joining our email list at http://intrepidwater.comJoin a supportive group of limit pushers at The Marathon Swimming CollectiveMusic credit:Epic Inspiration by Rafael KruxLink: https://filmmusic.io/song/5447-epic-inspiration-License: http://creativecommons.org/licenses/by/4.0/Swimming sounds courtesy of swimmer Todd Lantry.

This week, we’re doing a highlights episode! These are some of the moments that have stuck out to me from the amazing conversations I get to have each week. This time around, you’ll get to hear from Josh Radnor, Justin Jones, Lisa Sharon Harper, Joel Stein, Yusra Mardini, and Mike McHargue. If you’d like to listen to the full conversations, click on the link(s) below: Josh Radnor Justin Jones Lisa Sharon Harper Joel Stein Yusra Mardini Mike McHargue ___________________________________ SPONSOR: This episode of Let’s Give a Damn is brought to you by Red Kap — a fantastic company that makes workwear and uniforms. Not only is Red Kap a Nashville-based company — which I, of course, love because I live here right now — but they champion the men and women who are out there committed to making our communities thrive. Everything they make — from work shirts to coveralls — is crafted with purpose and on purpose. They’re a no BS company. What you see is what you get. And what you get is a group of people who genuinely give a damn about work, and a life, done right. From June 1 - July 31, you can get 20% off your first purchase at redkap.com with the promo code GIVEADAMN. Here’s something cool! I worked with them last month to interview amazing damn-givers that are beautifully contributing to their communities during this global pandemic. See more of my From The Frontlines interviews at redkap.com/communuity. ___________________________________ Follow Let’s Give A Damn on Facebook, Instagram, & Twitter to keep up with all that is going on. We have so much planned for the coming months and we don’t want you to miss a thing! Support us on Patreon! We can't do this without you. Lastly, leave us a 5-star rating and review on Apple Podcasts! Have an amazing week, friends! Keep giving a damn. Love y’all! Learn more about your ad choices. Visit megaphone.fm/adchoices

Yusra Mardini is a Syrian Refugee. In 2015, she and her sister left their home to head toward safety. A few minutes into the trip, the engine on their boat stopped working. She and her sister tread water for 3 1/2 hours which led to everyone’s lives being saved. Eventually, she arrived in Germany and began training for the 2016 Olympics. She competed at the 2016 Olympics in Rio on the very first Refugee Olympic Team. She is a UNHCR Goodwill Ambassador and swims every day as she trains for the next Olympics. Buy her book to hear the full version of her story. Follow Yusra on Instagram and Twitter. And visit her website to learn more about her. ___________________________________ SPONSOR: This episode of Let’s Give a Damn is brought to you by Red Kap — a fantastic company that makes workwear and uniforms. Not only is Red Kap a Nashville-based company — which I, of course, love because I live here right now — but they champion the men and women who are out there committed to making our communities thrive. Everything they make — from work shirts to coveralls — is crafted with purpose and on purpose. They’re a no BS company. What you see is what you get. And what you get is a group of people who genuinely give a damn about work, and a life, done right. From June 1 - July 31, you can get 20% off your first purchase at redkap.com with the promo code GIVEADAMN. Here’s something cool! I worked with them last month to interview amazing damn-givers that are beautifully contributing to their communities during this global pandemic. See more of my From The Frontlines interviews at redkap.com/communuity. ___________________________________ Follow Let’s Give A Damn on Facebook, Instagram, & Twitter to keep up with all that is going on. We have so much planned for the coming months and we don’t want you to miss a thing! Support us on Patreon! We can't do this without you. Lastly, leave us a 5-star rating and review on Apple Podcasts! Have an amazing week, friends! Keep giving a damn. Love y’all! Learn more about your ad choices. Visit megaphone.fm/adchoices

This past Saturday, June 20th, was World Refugee Day (https://www.unrefugees.org/refugee-facts/world-refugee-day/) , a day when we commemorate the strength, courage and perseverance of millions of refugees around the world. To me, the stories of refugees truly embody the resilience of the human spirit. They remind me that I am capable of hard things and that love and family and community are worth fighting for. As such, I hope that this episode will inspire you during this uncertain time in our nation's history. Today's guest, Nelda Ault-Dyslin, has extensive experience working with refugee communities, first at the Cache Refugee and Immigrant Connection (https://www.cacherefugees.org/) or CRIC, as they call it, in Logan Utah. I hope that as you listen, you might get one tiny idea of how you can be a better neighbor (https://3in30podcast.com/captivate-podcast/121-finding-purpose-with-brooke-snow/) and community member–or even just one tiny bit of knowledge that will help you to better understand the issues that you hear about in the news about refugees and immigration. Any effort you make to expand your worldview and become more aware of your neighbors matters! I am grateful to be part of a community of podcast listeners who deeply believes that. How to Help RefugeesThree Takeaways for Welcoming and Supporting Refugee Communities 1. Be creative and humble when learning about refugee communities. 2. Before assuming you know what kind of help a community member needs, ask them. 3. Support efforts and organizations that recognize the assets that refugees bring with them, instead of focusing only on the needs. Show Notes - Cache Refugee and Immigrant Connection (https://www.cacherefugees.org/) Other Episodes You Might Like Episode 110: How to Compassionately Respond to Homelessness (https://3in30podcast.com/captivate-podcast/110-how-to-compassionately-respond-to-homelessness-meg-martin/) Episode 132: Inspiring Bravery in Our Kids Through Role Models (https://3in30podcast.com/captivate-podcast/132-inspiring-bravery-in-our-kids-ashley-aikele-and-elyse-beard/) Episode 21: 3 Easy but Impactful Ways to Deepen Relationships with Others (https://3in30podcast.com/captivate-podcast/relationships/) Sponsor This month of episodes is brought to us by Yusra Mardini (https://www.yusra-mardini.com/) . For 10% off, use the code 3IN30 at checkout. Do you have any other questions about how to help refugees? What did you find most helpful? Let me know in a comment below!

A través de Mariposa, Yusra Mardini detalla su experiencia al salir de Siria en plena guerra civil con el claro objetivo de competir en los Juegos Olímpicos. En la segunda parte del podcast les platico sobre Sarah Mardini, la hermana de Yusra y cual ha sido su contribución para los refugiados, además del infierno que ha estado viviendo desde Agosto del 2018. Les comparto el enlace en donde pueden ver el video de la entrevista de Sarah Mardini: https://bit.ly/2TovOBa Recuerden darle like a este episodio, suscribirse al podcast y compartirlo con más lectores, me pueden encontrar en Instagram, Facebook y Goodreads como @lecturista y ahora también ya me pueden seguir en twitter como @lecturistamx

A través de Mariposa, Yusra Mardini detalla su experiencia al salir de Siria en plena guerra civil con el claro objetivo de competir en los Juegos Olímpicos. En la segunda parte del podcast les platico sobre Sarah Mardini, la hermana de Yusra y cual ha sido su contribución para los refugiados, además del infierno que ha estado viviendo desde Agosto del 2018. Les comparto el enlace en donde pueden ver el video de la entrevista de Sarah Mardini: https://bit.ly/2TovOBa Recuerden darle like a este episodio, suscribirse al podcast y compartirlo con más lectores, me pueden encontrar en Instagram, Facebook y Goodreads como @lecturista y ahora también ya me pueden seguir en twitter como @lecturistamx

In today's episode I talk to Yusra Mardini. We recorded this conversation in her flat in Hamburg, just before the world went into lockdown due to the Covid_19 pandemic.During this time of self-isolation, it seems more important than ever to amplify voices like Yusra's. As a Syrian refugee, Yusra knows what it feels like not to have borders open to her or the freedom to travel, and to be separated from loved ones for long periods of time. Her story is one of ultimate adversity and huge triumph. She became well known for swimming her boat to shore when crossing as a refugee from Turkey to Greece, then going on to swim in the Rio Olympics one year later, as just 17 years old. She has now written a book, met Barack Obama and advocates for refugees worldwide.  I'm sure that Yusra's story is exactly what is needed during this pivotal moment in history. In this episode we discuss social media, sisters, swimming and more. Her outlook, at such a young age, truly blew me away. I hope you enjoy it...Support the show (https://www.justgiving.com/prism-worldwidetribe)Support this show http://supporter.acast.com/asylum-speakers-podcast-with-jaz-ohara-stories-of-migration. See acast.com/privacy for privacy and opt-out information.

As a boat bound for Greece, filled with passengers attempting to flee war-torn Syria starting sinking - those on board feared the worst. But, over the course of three and a half monumental hours, Yusra Mardini and her sister Sara achieved the unthinkable as they jumped into the Aegean Sea and swam, guiding the boat to safety.Rob Pope speaks to this true superhuman as she explains and relives the terrifying ordeal. From arriving in Turkey and finding smugglers to facilitate their journey, to the four days spent waiting at the coast without food, shelter or water, to the devastating moment the boat's engine cut out just 20 minutes after leaving shore, Yusra shares every detail of the fateful crossing.Mercifully, Yusra's decision paid off – not only helping her find the peace she was so desperately searching for, but pursue her passion in a way she may never have thought possible...Listen to all episodes and discover more about How to Be Superhuman at http://redbull.com/superhuman

Yusra Mardini nasceu na Síria, um país que está em guerra. Perdeu tudo o que tinha menos a esperança. O esporte fez com que ela salvasse sua vida e de mais 20 pessoas. Conheça a história da nadadora que participou das Olimpíadas no Rio em 2016. :) Confira a playlist "Fafá conta histórias pro dia das mulheres" Livros legais que têm a ver com o tema: Histórias de Ninar Para Garotas Rebeldes - http://amzn.to/2lomEUW A menina que batizou plutão - http://amzn.to/2lorxxF Malala, a Menina que Queria Ir Para a Escola http://amzn.to/2lmnr9k Frida Kahlo. Para Meninas e Meninos - Volume 1 http://amzn.to/2kOfN4k Clarice Lispector Para Meninas e Meninos - http://amzn.to/2lohV60 Isabel - http://amzn.to/2kuvYr8 Frida (versão em espanhol) - http://amzn.to/2kuBOsS Martin E Rosa. Martin Luther King E Rosa Parks, Unidos Pela Igualdade - http://amzn.to/2lh9Ilg FINANCIE UM TRABALHO QUE VOCÊ GOSTA INSCREVA-SE NO CANAL NO YOUTUBE PODCAST "CONTA PRA MIM?" BLOG COM DICAS DE LITERATURA INFANTIL Me procure nas redes sociais: Facebook Instagram Histórias diferentes, para família toda curtir! História infantil para ninar, acordar, dormir, imaginar, crescer... "Fafá" é a versão contadora de histórias da atriz Flávia Scherner #históriadivertida #históriacontada #contaçãodehistoria

Ich möchte euch heute meinen Podcast vorstellen: Nono Yesyes - der Interview-Podcast über Persönlichkeitsentwicklung und die großen Themen des Lebens. Jeden Freitag spreche ich hier mit Gästen über ihre Lebensgeschichten und über die Fragen, die sich jeder stellt: Was ist Erfolg? Wie wird man mutig? Und wie bekommt man es hin, an sich selbst zu glauben? Bevor es am 03. Januar mit 3 Folgen losgeht, gebe ich euch heute schon einmal einen Einblick in die ersten Gespräche mit Lars Amend (Dieses bescheuerte Herz), Jil Zeletzki (Jiliciousjourney) und Micha Fritz (Viva con Agua). Die kompletten Folgen findet ihr ab dem 3. Januar auf Spotify und Apple Podcast. Danach gibt es dann jede Woche freitags eine neue Folge. Für die darf ich in der nächsten Zeit unter anderem mit Joko Winterscheidt, Mogli, Rene Adler, Lena Klenke oder Yusra Mardini sprechen. Damit ihr keinen dieser tollen Gäste verpasst, abonniert doch gerne den Kanal wenn ihr möchtet.

Das Mädchen, das ein Flüchtlingsboot rettete, und Olympia Schwimmerin wurde. In der heutigen Podcastfolge freue ich mich sehr, dir einen bemerkenswerten, jungen Menschen vorzustellen. Yusra Mardini ist 21 Jahre alt, Schwimmerin und vor vier Jahren aus ihrem Heimatland Syrien geflüchtet. In diesem menschlichen und ehrlichen Gespräch geht es um den Krieg, ihre Flucht und ihr Leben in Deutschland. Sie teilt ihre Perspektive zur Flüchtlingskrise und Rassismus mit uns und zeigt auf, wie wichtig menschliche Offenheit ist. "Don't judge a book by its cover." Ich wünsche dir ein spannendes Zuhören und ich hoffe, es wandelt deine Perspektive von einem Problem auf eine Herausforderung, die wir alle gemeinsam lösen dürfen. * Zu Yusra Mardinis Buch Butterfly. https://amzn.to/35Op1VV * Alles zu Yusra Mardini. https://go.homodea.com/hd209 * Die deutschen Untertitel zum Gespräch findest du hier auf YouTube. http://go.homodea.com/hd220 * Hier gehts zu homodea. http://go.homodea.com/hd191 * Alles zu Veit Lindau. https://go.veitlindau.com/bold-impact * Du kannst dir den Podcast überall auf iTunes, Spotify, meinem Blog, YouTube und allen Podcastapps kostenlos anhören. * Ich freu mich sehr, wenn dich die Folge inspiriert. Schreib mir sehr gern unter podcast@veitlindau.com dein Feedback oder deine Wünsche für weitere Themen und Gäste. In Verbundenheit, Dein Veit Folge direkt herunterladen

Det var en gång en flicka som hette Yusra. Hon växte upp i Syrien och det bästa hon visste var att simma! Men i hennes land var det krig och tillslut blev Yusra tvungen att fly. Det här är berättelsen om hur simningen räddade inte bara Yusras liv, utan väldigt många fler... Godnattsagor för rebelltjejer är en poddserie för 9-13-åringar om kvinnor som gått sin egen väg. Podcasten är ursprungligen producerad och skriven av Francesca Cavallo och Elena Favalli och bygger på den kända bokserien med samma namn. Medverkande i detta avsnitt Författare: Francesca Cavallo och Elena Favalli Uppläsare: Alba August Illustratör: Jessica Cooper, Copyright © Timbuktu Labs, inc Producent av den svenska versionen: Astrid Mohlin, Barnradion

durée : 00:02:35 - Les enfants des livres - par : Cécile Ribault Caillol - "Butterfly", c'est l'histoire vraie et hors du commun de Yusra Mardini, une jeune réfugiée syrienne devenue nageuse olympique et ambassadrice des Nations Unies. Et c'est le choix de Lilou, 17 ans.

Ich freue mich so sehr, heute wieder ein Interview mit dir im Podcast zu teilen. Es ist ein Interview, das mich persönlich so tief berührt hat wie bisher kein anderes. Ich spreche mit Yusra Mardini über ihre Flucht aus Syrien, was sie alles erlebt hat und wie es ihr seitdem geht.   Yusra Mardini hat bei der Bootsüberfahrt von der Türkei nach Griechenland zusammen mit ihrer Schwester 3,5 Stunden das Boot gezogen bzw. hat dabei geholfen, dass es nicht umkippt und in die richtige Richtung fährt. Sie erzählt außerdem, wie es dazu kam, dass sie im Olympischen Team der Flüchtlinge mitgeschwommen ist und was das für sie bedeutet hat.   Dieses Interview hat mich tief bewegt und ich hoffe, dass es dich auch inspiriert, dein Herz zu öffnen und dass wir den Menschen helfen, die unsere Hilfe benötigen. Denn wir sind alle miteinander verbunden und das ist es, was uns letztlich zu Menschen macht: dass wir unsere Herzen öffnen und füreinander da sind.   Im Gespräch mit Yusra Mardini erfährst du: Warum wir uns gegenseitig mehr helfen sollten, Wie das Leben von Flüchtlingen in Deutschland ist und wie wir sie unterstützen können, Wie wichtig es ist, die eigene Geschichte zu teilen und andere damit zu inspirieren und Warum wir unseren Alltag und unser Leben mehr wertschätzen sollten. Was denkst du, wie wir uns gegenseitig noch mehr helfen und mit offenen Herzen aufeinander zugehen können? Ich bin sehr gespannt, wie dir das Interview gefällt und freue mich auf deine Erkenntnisse und Gedanken zur Folge. Kommentiere super gerne auf Instagram @lauramalinaseiler oder auf dem Blog.   Links zu Yusra Mardini: Instagram: @mardiniysra Buch: Butterfly https://amzn.to/31H9JjG   Rock on & Namasté Deine Laura   Hier findest du alle Links zu Laura Malina Seiler:  Instagram: @lauramalinaseile  Website: www.lauraseiler.com Mein neue Buch #1 Spiegelbestseller Schön, dass es dich gibt! Jetzt hier bestellen: https://amzn.to/2EhNYgG Zur Rise Up & Shine Uni kannst du dich hier anmelden: www.higherselfon.de Zum Higher Self Home kannst du dich hier anmelden: https://lauraseiler.com/higher-self-home/

CJ and Melissa discuss Syrian swimmer Yusra Mardini, scientist Rosalind Franklin, and the king of baby back b*!@hes. Follow us on Twitter @mimosahood and Instragram @mimosasisterhood See acast.com/privacy for privacy and opt-out information.

Yusra nearly drowned in the Aegean Sea when she fled Syria and became a refugee. She steadied a boat with her sister - saving the lives of the people on board. She went on to compete at Rio 2016 and won her swimming heat. We talked to her about her Instagram feed and practical ways people can help refugees.

If you have a look at Yusra Mardini’s Instagram feed – there are clues about what she does: pictures of swimming training and plenty of selfies. She’s clearly an international standard athlete. But her story runs deep – after fleeing Syria and swimming for 10km alongside a boat of displaced people looking for a new start, she ended up in Germany training for the Olympics. She refuses to be defined by her status as a refugee and wants you to reassess what you think about the word too. In a huge act of kindness, marathon runner Gatkuoth Puok Thiep gave up his place on the Refugee Olympic Team. He lost his father, mother and sister to the war in South Sudan. His inspiring story, although tragic, is full of hope about the future. We sat down with both for World Refugee Day. Don’t forget to subscribe for more of the best Olympic talking points every week. And leave a five star review on iTunes and other places if you liked what you heard. We want you to think just like an Olympian. LINKS: SPORTSPIEL: https://sportspielonline.com/ BOOK: https://www.panmacmillan.com/authors/yusra-mardini/butterfly WE ARE ONE DOCUMENTARY: https://www.olympicchannel.com/en/features/we-are-one/

Era uma vez uma menina que adorava nadar. Seu nome era Yusra Mardini. Ela nasceu em Damasco, na Síria, um país há muito tempo tomado pela guerra. Quando sua casa foi destruída por uma bomba, sabia que teria que deixar o país, então ela e sua família fugiram em um barco cheio de refugiados. Quando o motor quebrou, ela e suas irmãs se tornaram heroínas, nadando e puxando o barco para segurança. Na Alemanha, Yusra encontrou a glória como uma das primeiras equipes de refugiados a competir nas Olimpíadas. Essa história inspiradora é lida por Poliana Okimoto, maratonista aquática brasileira que nos Jogos Olímpicos Rio 2016 se tornou a primeira nadadora do país a conquistar medalha olímpica na natação. -- #MulheresPraFrente Apresentado por Bradesco. Pensar pra frente é bancar a mudança. banco.bradesco/mulheresprafrente -- Histórias de Ninar Para Garotas Rebeldes: 100 fábulas sobre mulheres extraordinárias. Conheça o livro: no.b9.com.br/2rF3FHy -- Contato e Créditos Envie seus comentários para garotasrebeldes@b9.com.br. Esse podcast foi produzido por B9, em parceria com Timbuktu Labs e Bradesco, e é baseado na série de livros "Histórias de Ninar Para Garotas Rebeldes", publicado no Brasil pela V&R Editora. Escrito pelas produtoras executivas Elena Favilli e Francesca Cavallo. Edição por Robson Bravo. Sound Design e trilha sonora original de Elettra Bargiacchi. Tradução de Juliana Geve. Coordenação de Ju Wallauer e produção de Annie Zanneti. Copyright © 2018 Timbuktu Labs, Inc. Adaptado do podcast originalmente publicado em inglês Baseado em "Histórias de Ninar Para Garotas Rebeldes: 100 fábulas sobre mulheres extraordinárias" Por Francesca Cavallo e Elena Favilli (Todos os direitos reservados em todos os países por Timbuktu Labs, Inc.)

Sione's story: the next chapter A few months ago Sportshour told the story of the Tongan Rugby player Sione Vaiomounga. Having travelled to Romania to play, he suffered kidney failure. With no dialysis machines in his native Tonga, Sione believed returning home would be a death sentence, But things are now looking up for Sione. The road from Jerusalem: As the Giro D'Italia gets underway in Jerusalem we hear from the country's top riders, those who welcome the arrival of the race and those who oppose it. What price for sporting success? India won a record 26 gold medals at the recent Commonwealth Games It's led to calls for the Government to invest more in its sporting infrastructure. But in a country that is home to almost a third of the world’s poor, should sport be a priority? Swimming to safety: Yusra Mardini's swimming ability took her to the Rio Olympics and she's now training for Tokyo in 2020.. But swimming also saved her life as she made the dangerous journey with 20 other Syrian refugees across the Mediterranean in a dingy. The boat designed for six, took on water and Yusra and her sister were among those who swam to safety. Now based in Germany, Yusra's an international voice for refugees and her story's about to become a Hollywood movie Football pioneer: A host of international stars are set to feature in the 2018 Women's FA Cup final at Wembley. Things were rather different when the former New Zealand international Donna Baker turned out for Knowsley United against Doncaster Belles in the 1994 final, staged at Scunthorpe.

Is the world's future in good hands? Four-time Olympic champion Johann Olav Koss gives his reasons to be optimistic. Plus, Syrian refugee swimmer Yusra Mardini stands as an example to show that her generation can have a ‘no excuses’ attitude. Remember that if you like the podcast - subscribe and leave a five-star review where you can… (Update - we had to resend because of an audio glitch - all fixed now!)

Once, there was a girl who loved to swim. Her name was Yusra Mardini. She was born in Damascus, Syria, a country long gripped by war. When her home was destroyed by a bomb she knew she had to leave the country, so she and her family fled by way of a boat filled with too many refugees. When the motor broke down, she and her sisters became heroes, swimming and pulling the boat to safety. In Germany, Yusra found glory as one of the first refugee teams ever to compete in the Olympics.Sponsored by:www.rebelgirls.co Use promo code REBELPODCAST to get 15% off your first purchase!ABOUT DIANA NYADOn September 2, 2013, at the age of sixty-four, Diana Nyad became the first person to swim from Cuba to Florida without the aid of a shark cage, swimming 111 miles in fifty-three hours from Havana to Key West. In the 1970s, she became known as the world’s greatest long-distance swimmer with her open-water achievements, including a record-breaking swim around Manhattan. For the next thirty years, Nyad was a prominent sports broadcaster and journalist, filing compelling stories for National Public Radio, ABC’S Wide World of Sports, and others. She is the author of the upcoming memoir, "Find a Way," and three other books, is a national fitness icon, a talented linguist, and one of today’s most powerful and engaging public speakers.This episode of Good Night Stories for Rebel Girls is produced by Elena Favilli and Francesca Cavallo, with writing and operation support by Darby Maloney and Elyssa Dudley. Sound Design and Original Theme Music by Elettra Bargiacchi.

Once, there was a girl who loved to swim. Her name was Yusra Mardini. She was born in Damascus, Syria, a country long gripped by war. When her home was destroyed by a bomb she knew she had to leave the country, so she and her family fled by way of a boat filled with too many refugees. When the motor broke down, she and her sisters became heroes, swimming and pulling the boat to safety. In Germany, Yusra found glory as one of the first refugee teams ever to compete in the Olympics.Sponsored by:www.rebelgirls.co Use promo code REBELPODCAST to get 15% off your first purchase!ABOUT DIANA NYADOn September 2, 2013, at the age of sixty-four, Diana Nyad became the first person to swim from Cuba to Florida without the aid of a shark cage, swimming 111 miles in fifty-three hours from Havana to Key West. In the 1970s, she became known as the world’s greatest long-distance swimmer with her open-water achievements, including a record-breaking swim around Manhattan. For the next thirty years, Nyad was a prominent sports broadcaster and journalist, filing compelling stories for National Public Radio, ABC’S Wide World of Sports, and others. She is the author of the upcoming memoir, "Find a Way," and three other books, is a national fitness icon, a talented linguist, and one of today’s most powerful and engaging public speakers.This episode of Good Night Stories for Rebel Girls is produced by Elena Favilli and Francesca Cavallo, with writing and operation support by Darby Maloney and Elyssa Dudley. Sound Design and Original Theme Music by Elettra Bargiacchi.

Il y a tout juste deux jours, on célébrait l'ouverture des 23 e Jeux Olympiques d'hiver enCorée du Sud. L'occasion pour Radio-Dodo de te faire découvrir les musiques et hymnesdes JO. Benoit Huot parle de sa passion pour le sport et la natation au micro de Brigitte Alepin.Par la suite, Sanaa Bendahmane répondra à la question : ‘' Qu'est-ce que les JeuxOlympiques ?'' Suivi du témoignage de Yusra Mardini, jeune réfugiée syrienne qui réaliseson rêve olympique : Celui de participer aux Jo ! Pour clôturer cet épisode, nous souhaiterons la bienvenue à nos amis Maliens enpartageant de la musique venue tout droit du Mali !

Il y a tout juste deux jours, on célébrait l’ouverture des 23 e Jeux Olympiques d’hiver enCorée du Sud. L’occasion pour Radio-Dodo de te faire découvrir les musiques et hymnesdes JO. Benoit Huot parle de sa passion pour le sport et la natation au micro de Brigitte Alepin.Par la suite, Sanaa Bendahmane répondra à la question : ‘’ Qu’est-ce que les JeuxOlympiques ?’’ Suivi du témoignage de Yusra Mardini, jeune réfugiée syrienne qui réaliseson rêve olympique : Celui de participer aux Jo ! Pour clôturer cet épisode, nous souhaiterons la bienvenue à nos amis Maliens enpartageant de la musique venue tout droit du Mali !

In Episode 13 of Burn It All Down, the whole gang is back together to discuss the NF'nL. Julie DiCaro, Shireen Ahmed, Lindsay Gibbs, Brenda Elsey, and Jessica Luther talk about the NFL where domestic violence investigations continue to be terrible, CTE is back at the forefront of the discussion, and where Colin Kaepernick still can’t get a job, Lucky Whitehead can't keep his, and John Urshel doesn't want his anymore. Then Brenda and Shireen interview Ann Odong, expert on all things women's soccer and editor of The Women's Game (http://thewomensgame.com), about the UEFA Women's EURO 2017 soccer tournament. Plus, you’ll hear The Burn Pile and Badass Woman of the Week! Correction: Simone Manuel beat Sarah Sjöström, the world recorder holder in the 100m, to win the 100m freestyle title at the world championships. We incorrectly said that Manuel had beaten Yulia Efimova. Show notes: Intro ~ Discussion about the NFL’s failure to handle domestic violence cases properly, including Ezekiel Elliott’s (still) pending domestic violence case, per Diana Moskovitz’s piece at Deadspin. (1:10). What ever happened to the NFL’s baseline six-game suspension for domestic violence cases? (1:50) Colin Kaepernick still can’t get a job in the NFL, but he’s not being blackballed! Shireen talks about the hypocrisy of the league in failing to offer Kap a job, via Jemele Hill’s hilarious (and sad) tweet. (4:37) The Dallas Cowboys continue to be terrible, Jessica breaks down Lucky Whitehead’s horrible, terrible, no good, very bad day. (12:23) Lindsay brings us up -to-speed on the latest news about CTE in NFL players, via the big story in the NYT this week. (17:37) The panel discusses Raven Offensive Lineman and world-reknowned mathematician John Urschel’s retirement two days after the CTE report was released. (19:31) Julie talks about her discussion with Dr. Chris Nowinski about kids playing tackle football and his views on youth sports. (22:59) Brenda discusses the role of parents and schools in protecting children in sport. (23:52) Lindsay points out there are no federal guidelines for safety in high school football or lower levels. (26:10) Outside the Lines report on the NFL ending it’s relationship with the National Institute of Health. (27:25) Brenda and Shireen interview Australian sportswriter Ann Odong about the ongoing women’s Euro’s Soccer Tourney (28:45) Burn Pile: (43:52) Lindsay burns Britt McHenry’s “awakening” as a conservative commentator. (44:00) Shireen sets aflame sexism in the Tour de France (47:08). Brenda takes a lighter to the treatment of the Mexican Women’s National Soccer team by their home federation. (48:50) Julie throws gas on LaVar Ball and Adidas’ actions at the Adidas Las Vegas basketball tournament. (50:43) Jessica lights up ESPN for showing corn hole/bags and drone racing rather than the women’s Euros soccer tourney. (52:45) Hilarity over the name “corn hole” ensues. (54:25) BAWOW: (55:13) Shireen tells us about Yusra Mardini and her return to Budapest to swim for refugees everywhere. She’s the BAWOW. Julie awards an Honorable Mention to baseball beat reporter Claire Smith. (56:57) Jessica tosses an Honorable Mention to friend-of-the-show Bilqis Abdul-Qaadir for winning the Leadership in Sport Award from Beyond Sport. (57:52) Shireen honors swimmer Simone Manuel for winning the 100M at the FINA Championships. (58:23) Lindsay is looking forward to watching live tennis at the Citi Open in DC this week. (59:19) Jessica is loving reading Women’s Gold Medalists: Rio Olympics 2016. (100:13) Brenda can’t wait for the US v. Japan soccer match in the Tournament of Nations on August 3. (101:24) Shireen is excited for the Euros and Anna Kessel’s book Eat, Sweat, Play. (102:03) Julie is finally diving into the book Rejected Princesses. (102:27)

The story Yusra Mardini, the teenage Syrian refugee who swam to survive, and was then selected to compete in the pool for the refugee team at the Olympic Games in Rio. Freelance journalist Magdalena Sodomkova travelled with Yusra, her sister and other refugees as they approached the Hungarian border, eventually making their way to Germany, and beginning a new life in Berlin.