Podcast appearances and mentions of eric goldstein

In this episode, Eric Goldstein and Trico Fullerton sit down to go over all the craziness that went down in the wrestling world recently, such as Aleister Black being back in WWE, Zelina Vega capturing her first singles title, and all the fun indy action going on this weekend!Please stay up to date with everything going on in the community. Subscribe to our website at Respectthecombat.com to keep up to date with all the news and latest episodes of RTC that are being released!

In this episode, Eric Goldstein and Trico Fullerton sit down with The Ranch Hand & Head Trainer of the 1CW Dojo in Delaware, Shawn Carlson. We talk about all the craziness that happened during WrestleMania Week, how Bryan Idol has been a huge influence to him, and much, much more!Please stay up to date with everything going on in the community. Subscribe to our website at Respectthecombat.com to keep up to date with all the news and latest episodes of RTC that are being released!

In this episode, Eric Goldstein and Trico Fullerton Sit down with World Wrestling Network Ring Announcer, Michael James. We talked about Giulia returning to NXT, Talk a little old school Attitude Era, as well as talk how Michael broke into the business initially.Please stay up to date with everything going on in the community, Subscribe to our website at Respectthecombat.com to keep up to date with all the news and latest episodes of RTC that are being released!

In this episode, Eric Goldstein and Irving Ortiz Sit down with GTS Youtube Legendary Heavyweight Champion, Radley Belmont. We talk about Fenix debuting for WWE, as well as the craziness that has gone down in his career, including an "unofficial" title change at Denny's!Please stay up to date with everything going on in the community, Subscribe to our website at Respectthecombat.com to keep up to date with all the news and latest episodes of RTC that are being released!

In this episode, Eric Goldstein and Irving Ortiz Sit down with Independent Wrestler Floyd Maystorm. They discuss his illustrious career, go over Moose's presence in NXT, and all the other craziness that happened this week.Please stay up to date with everything going on in the community, Subscribe to our website at Respectthecombat.com to keep up to date with all the news and latest episodes of RTC that are being released!

In this episode, we're joined by Eric Goldstein, Chief Strategy Officer at TIAA, to explore the challenges and opportunities of setting up and operating a strategy office. With over six years at TIAA and an impressive background in investment banking at JP Morgan and management consulting at McKinsey, Eric brings a wealth of experience to the table. We dive into Eric's journey of centralizing the strategy office at TIAA, the importance of aligning strategy with business goals, and how he navigates the complexities of managing a large, mission-driven financial services organization. We'll also discuss the role of the strategy office in fostering cross-functional collaboration, setting organizational KPIs, and striking the right balance between strategy development and execution. Key questions and topics we tackle include: A breakdown of the TIAA strategy office responsibilities How to decide whether to centralize or decentralize the strategy office Keys to building a high-performing strategy team A CSOs role in setting KPIs, metrics, and measurements in the organization How to build and maintain strong relationships with key stakeholders Eric's top 3 recommendations for new strategy officers to drive success Join us for an in-depth conversation with Eric Goldstein as we uncover the secrets behind building and operating a successful strategy office.   Learn more about Outthinker's community of chief strategy officers - https://outthinkernetwork.com/ Follow us on LinkedIn - https://www.linkedin.com/company/outthinker-networks

The City, Adams Family Values: A Guide to the Kin and Friends New York City's Mayor Relies On;https://www.thecity.nyc/2024/09/12/eric-adams-family-nypd-connections-fbi-investigation-banks-caban/AP, A tech company hired a top NYC official's brother. A private meeting and $1.4M in contracts followedhttps://apnews.com/article/new-york-mayor-federal-investigation-banks-b2369819ff7ccd4e630899eb08538bae?ref=biztoc.comDaily News, Firm doing business with NYC met with Schools Chancellor David Banks after hiring brother Terencehttps://www.nydailynews.com/2024/09/13/firm-doing-business-with-nyc-met-with-schools-chancellor-david-banks-after-hiring-brother-terence-banks-fbi-probe/The City, A Tech Firm Ditched a Power Lobbyist — and Called on the Schools Chancellor's Brotherhttps://www.thecity.nyc/2024/09/09/terence-banks-saferwatch-corey-johnson-david-phil/NY Post, NYC school chancellor's brother bragged about political connections — but scrubbed his website after FBI raid of Adams' aideshttps://nypost.com/2024/09/08/us-news/school-chancellors-brother-bragged-about-political-connections-but-scrubbed-his-website-after-federal-raid/NY Post, NYC Schools Big Gets Off Easy in Chicken Bribe Casehttps://nypost.com/2024/09/09/us-news/nyc-schools-big-eric-goldstein-gets-off-easy-in-chicken-bribe-case/NY Post, NYC Educrats Took Own Kids to Magic Kingdom on Trips Meant for Homeless Studentshttps://nypost.com/2024/09/15/us-news/what-happens-in-disney-stays-in-disney-nyc-educrats-took-own-kids-to-magic-kingdom-on-trips-meant-for-homeless-students/Special Commissioner of Investigation for the NYC School District, DOE Students in Temporary Housing (“STH”) Regional Manager and Others Brought Family Members on DOE-funded Out-of-Town Trips Meant for Homeless Students.https://nycsci.org/wp-content/uploads/2024/09/20191844_Redacted.pdfChalkbeat, NYC new education board chair pick is same as old chair, despite effort to distance role from mayorhttps://www.chalkbeat.org/newyork/2024/09/14/mayor-eric-adams-picks-gregory-faulkner-for-panel-for-educational-policy-chair/NY Post, Eric Adams fails to name third trustee to oversee billions of dollars in NYC school constructionhttps://nypost.com/2024/08/31/us-news/eric-adams-fails-to-name-nyc-trustee-to-oversee-billions-of-dollars-in-school-construction/NY Post, Almost 50% of NYC teachers don't trust embattled DOE Chancellor David Banks: surveyhttps://nypost.com/2024/09/14/us-news/almost-50-of-nyc-school-teachers-dont-trust-embattled-doe-chancellor-david-banks-report/Letter to Mayor, Chancellor & NYC Health Commissioner regarding privacy concerns with Teenspace mental health services https://studentprivacymatters.org/privacy-concerns-about-nycs-promotion-of-the-teenspace-online-counseling-service/State Scoop, Privacy advocates are concerned by NYC's online teen counseling servicehttps://statescoop.com/privacy-advocates-nyc-teen-counseling-talkspace/Chalkbeat, Data privacy advocates raise alarm over NYC's free teen teletherapy programhttps://www.chalkbeat.org/newyork/2024/09/10/privacy-advocates-raise-concerns-free-teletherapy-teens-data/Daily News, Advocates raise alarm about privacy with NYC's teen mental telehealth servicehttps://www.nydailynews.com/2024/09/10/advocates-raise-alarm-about-privacy-with-nycs-teen-mental-telehealth-service/Talkspace Lawsuit Claims Therapy Website Secretly Shares User Data with TikTokhttps://www.classaction.org/news/talkspace-lawsuit-claims-therapy-website-secretly-shares-user-data-with-tiktok

Eric Goldstein, Executive Assistant Director for Cybersecurity at Cybersecurity and Infrastructure Security Agency, is sharing his thoughts on where cybersecurity has been and is going as he is leaving CISA. Ben has the story of Google laying off members of the team that reviews law enforcement data requests. Dave's got the story of teens using AI to undress their peers. While this show covers legal topics, and Ben is a lawyer, the views expressed do not constitute legal advice. For official legal advice on any of the topics we cover, please contact your attorney.  Please take a moment to fill out an audience survey! Let us know how we are doing! Links to the stories: Google cuts part of team that vets police requests for user data Teens Are Spreading Deepfake Nudes of One Another. It's No Joke Caveat Briefing A companion weekly newsletter is available CyberWire Pro members on the CyberWire's website. If you are a member, make sure you subscribe to receive our weekly wrap-up of privacy, policy, and research news, focused on incidents, techniques, tips, compliance, rights, trends, threats, policy, and influence ops delivered to you inbox each Thursday. Got a question you'd like us to answer on our show? You can send your audio file to caveat@thecyberwire.com. Hope to hear from you. Learn more about your ad choices. Visit megaphone.fm/adchoices

Operation Endgame takes down malware operations around the globe. A major botnet operator is arrested. Ticketmaster's massive data breach is confirmed, and so is Google's SEO algorithm leak. Journalists and activists in Europe were targeted with Pegasus spyware. Okta warns users of credential stuffing attacks. NIST hopes to clear out the NVD backlog. On our Threat Vector segment, host David Moulton speaks with Greg Jones, Chief Information Security Officer at Xavier University of Louisiana. Eric Goldstein, Executive Assistant Director for Cybersecurity at CISA, joins us to discuss software security. LightSpy surveillance malware comes to macOS. ChatGPT briefly gets a god mode. Our 2024 N2K CyberWire Audience Survey is underway, make your voice heard and get in the running for a $100 Amazon gift card. Remember to leave us a 5-star rating and review in your favorite podcast app. Miss an episode? Sign-up for our daily intelligence roundup, Daily Briefing, and you'll never miss a beat. And be sure to follow CyberWire Daily on LinkedIn. CyberWire Guest Eric Goldstein, Executive Assistant Director for Cybersecurity at CISA, joins us to discuss software security. Threat Vector In this Threat Vector segment, host David Moulton speaks with Greg Jones, Chief Information Security Officer at Xavier University of Louisiana. Greg brings a wealth of knowledge from his military background and applies a disciplined, adaptive approach to securing one of America's most vibrant educational institutions. You can listen to David and Greg's full discussion here.  Selected Reading Police seize malware loader servers, arrest four cybercriminals (Bleeping Computer) Is Your Computer Part of ‘The Largest Botnet Ever?' (Krebs on Security) Ticketmaster hacked. Breach affects more than half a billion users. (Mashable) Google confirms the leaked Search documents are real (The Verge) Phones of journalists and activists in Europe targeted with Pegasus (CyberScoop) Okta Warns of Credential Stuffing Attacks Targeting Cross-Origin Authentication (SecurityWeek) NIST says NVD will be back on track by September 2024 (Help Net Security) macOS version of elusive 'LightSpy' spyware tool discovered (Bleeping Computer) Hacker Releases Jailbroken "Godmode" Version of ChatGPT (Futurism)  Share your feedback. We want to ensure that you are getting the most out of the podcast. Please take a few minutes to share your thoughts with us by completing our brief listener survey as we continually work to improve the show.  Want to hear your company in the show? You too can reach the most influential leaders and operators in the industry. Here's our media kit. Contact us at cyberwire@n2k.com to request more info. The CyberWire is a production of N2K Networks, your source for strategic workforce intelligence. © N2K Networks, Inc.

Healthcare providers report breaches affecting millions. PlugX malware is found in over 170 countries. Hackers exploit an old vulnerability to launch Cobalt Strike. A popular Wordpress plugin is under active exploitation. Developing nations may serve as a test bed for malware developers. German authorities question Microsoft over Russian hacks. CISA celebrates the success of their ransomware warning program. Our guest is Eric Goldstein, Executive Assistant Director for Cybersecurity at CISA, discussing open source software. Password trends are a mixed bag. Remember to leave us a 5-star rating and review in your favorite podcast app. Miss an episode? Sign-up for our daily intelligence roundup, Daily Briefing, and you'll never miss a beat. And be sure to follow CyberWire Daily on LinkedIn. CyberWire Guest Our guest is Eric Goldstein, Executive Assistant Director for Cybersecurity at CISA, discussing open source software. Selected Reading Kaiser Permanente data breach may have impacted 13.4 million patients (Security Affairs) LA County Health Services: Patients' data exposed in phishing attack (Bleeping Computer) China-linked PlugX malware infections found in more than 170 countries (The Record) Hackers Exploit Old Microsoft Office 0-day to Deliver Cobalt Strike (GB Hackers) Critical WordPress Automatic Plugin Vulnerability Exploited to Inject Backdoors (SecurityWeek) Cybercriminals are using developing nations as test beds for ransomware attacks (TechSpot) Microsoft Questioned by German Lawmakers About Russian Hack (GovInfo Security) More than 800 vulnerabilities resolved through CISA ransomware notification pilot (The Record) Most people still rely on memory or pen and paper for password management (Help Net Security)   Share your feedback. We want to ensure that you are getting the most out of the podcast. Please take a few minutes to share your thoughts with us by completing our brief listener survey as we continually work to improve the show.  Want to hear your company in the show? You too can reach the most influential leaders and operators in the industry. Here's our media kit. Contact us at cyberwire@n2k.com to request more info. The CyberWire is a production of N2K Networks, your source for strategic workforce intelligence. © 2023 N2K Networks, Inc.

Podcast: Control Loop: The OT Cybersecurity Podcast (LS 34 · TOP 3% what is this?)Episode: Hunting adversaries.Pub date: 2024-04-03Sellafield nuclear waste site to be prosecuted for alleged cybersecurity failings. CISA issues draft proposal for cyber incident reporting by critical infrastructure entities. Threat actor targets Indian government and energy entities. Suspicious NuGet package appears to target developers in the industrial sector. Guest Eric Goldstein, Executive Assistant Director for Cybersecurity at CISA, shares their CIRCIA Notice of Proposed Rulemaking. The Learning Lab returns! Mark Urban and Josh Hanrahan discuss adversary hunting.Control Loop News Brief.Sellafield nuclear waste site to be prosecuted for alleged cybersecurity failings.Sellafield nuclear waste dump to be prosecuted for alleged cybersecurity offences (The Guardian)Sellafield nuclear site hacked by groups linked to Russia and China (The Guardian)CISA issues draft proposal for cyber incident reporting by critical infrastructure entities.CISA releases draft rule for cyber incident reporting (CyberScoop)Threat actor targets Indian government and energy entities.Operation FlightNight: Indian Government Entities and Energy Sector Targeted by Cyber Espionage Campaign (EclecticIQ)Suspicious NuGet package appears to target developers in the industrial sector.Suspicious NuGet package grabs data from industrial systems (ReversingLabs)Control Loop Interview.Guest is Eric Goldstein, Executive Assistant Director for Cybersecurity at  CISA. Eric shares their CIRCIA Notice of Proposed Rulemaking that goes into effect this week.Control Loop Learning Lab.The Learning Lab is back! On today's segment, listen to Dragos' Mark Urban talking with Josh Hanrahan, Principal Adversary Hunter at Dragos, in part one of their discussion on adversary hunting and VOLTZITE (aka Volt Typhoon). Resources: VOLTZITE Threat Group's Under the Radar Cyber Espionage on U.S. Critical Systems . Control Loop Audience Survey.Please take a moment to fill out our super quick survey. Thanks!Control Loop OT Cybersecurity Briefing.A companion monthly newsletter is available through free subscription and on N2K Networks website.The podcast and artwork embedded on this page are from N2K Networks, which is the property of its owner and not affiliated with or endorsed by Listen Notes, Inc.

Podcast: Control Loop: The OT Cybersecurity Podcast (LS 35 · TOP 3% what is this?)Episode: Hunting adversaries.Pub date: 2024-04-03Sellafield nuclear waste site to be prosecuted for alleged cybersecurity failings. CISA issues draft proposal for cyber incident reporting by critical infrastructure entities. Threat actor targets Indian government and energy entities. Suspicious NuGet package appears to target developers in the industrial sector. Guest Eric Goldstein, Executive Assistant Director for Cybersecurity at CISA, shares their CIRCIA Notice of Proposed Rulemaking. The Learning Lab returns! Mark Urban and Josh Hanrahan discuss adversary hunting.Control Loop News Brief.Sellafield nuclear waste site to be prosecuted for alleged cybersecurity failings.Sellafield nuclear waste dump to be prosecuted for alleged cybersecurity offences (The Guardian)Sellafield nuclear site hacked by groups linked to Russia and China (The Guardian)CISA issues draft proposal for cyber incident reporting by critical infrastructure entities.CISA releases draft rule for cyber incident reporting (CyberScoop)Threat actor targets Indian government and energy entities.Operation FlightNight: Indian Government Entities and Energy Sector Targeted by Cyber Espionage Campaign (EclecticIQ)Suspicious NuGet package appears to target developers in the industrial sector.Suspicious NuGet package grabs data from industrial systems (ReversingLabs)Control Loop Interview.Guest is Eric Goldstein, Executive Assistant Director for Cybersecurity at  CISA. Eric shares their CIRCIA Notice of Proposed Rulemaking that goes into effect this week.Control Loop Learning Lab.The Learning Lab is back! On today's segment, listen to Dragos' Mark Urban talking with Josh Hanrahan, Principal Adversary Hunter at Dragos, in part one of their discussion on adversary hunting and VOLTZITE (aka Volt Typhoon). Resources: VOLTZITE Threat Group's Under the Radar Cyber Espionage on U.S. Critical Systems . Control Loop Audience Survey.Please take a moment to fill out our super quick survey. Thanks!Control Loop OT Cybersecurity Briefing.A companion monthly newsletter is available through free subscription and on N2K Networks website.The podcast and artwork embedded on this page are from N2K Networks, which is the property of its owner and not affiliated with or endorsed by Listen Notes, Inc.

Sellafield nuclear waste site to be prosecuted for alleged cybersecurity failings. CISA issues draft proposal for cyber incident reporting by critical infrastructure entities. Threat actor targets Indian government and energy entities. Suspicious NuGet package appears to target developers in the industrial sector. Guest Eric Goldstein, Executive Assistant Director for Cybersecurity at CISA, shares their CIRCIA Notice of Proposed Rulemaking. The Learning Lab returns! Mark Urban and Josh Hanrahan discuss adversary hunting. Control Loop News Brief. Sellafield nuclear waste site to be prosecuted for alleged cybersecurity failings. Sellafield nuclear waste dump to be prosecuted for alleged cybersecurity offences (The Guardian) Sellafield nuclear site hacked by groups linked to Russia and China (The Guardian) CISA issues draft proposal for cyber incident reporting by critical infrastructure entities. CISA releases draft rule for cyber incident reporting (CyberScoop) Threat actor targets Indian government and energy entities. Operation FlightNight: Indian Government Entities and Energy Sector Targeted by Cyber Espionage Campaign (EclecticIQ) Suspicious NuGet package appears to target developers in the industrial sector. Suspicious NuGet package grabs data from industrial systems (ReversingLabs) Control Loop Interview. Guest is Eric Goldstein, Executive Assistant Director for Cybersecurity at  CISA. Eric shares their CIRCIA Notice of Proposed Rulemaking that goes into effect this week. Control Loop Learning Lab. The Learning Lab is back! On today's segment, listen to Dragos' Mark Urban talking with Josh Hanrahan, Principal Adversary Hunter at Dragos, in part one of their discussion on adversary hunting and VOLTZITE (aka Volt Typhoon).  Resources: VOLTZITE Threat Group's Under the Radar Cyber Espionage on U.S. Critical Systems .  Control Loop Audience Survey. Please take a moment to fill out our super quick survey. Thanks! Control Loop OT Cybersecurity Briefing. A companion monthly newsletter is available through free subscription and on N2K Networks website.

The Pentagon unveils its cybersecurity roadmap. A major Massachusetts health insurer reveals a massive data breach. Hot Topic reports credential stuffing. Cisco warns of password spraying targeting VPNs. The FS-ISAC highlights the risk of generative AI to financial institutions. The FEC considers efforts to combat deceptive artificial intelligence. A look at Thread Hijacking attacks. Guests Linda Gray Martin and Britta Glade from RSA Conference join us to discuss what's new and what to look forward to at this year's big show. Plus my conversation with Eric Goldstein, Executive Assistant Director for Cybersecurity at  CISA, with insights on their recent Notice of Proposed Rulemaking. And Baltimore's tragic bridge collapse lays bare the degeneration of X-Twitter.  Remember to leave us a 5-star rating and review in your favorite podcast app. Miss an episode? Sign-up for our daily intelligence roundup, Daily Briefing, and you'll never miss a beat. And be sure to follow CyberWire Daily on LinkedIn. CyberWire Guest Guests Linda Gray Martin, Senior Vice President for Operations, and Britta Glade, Vice President for Content and Curation, join us to discuss what's new and what to look forward to at RSA Conference 2024. This year's theme is the Art of Possible.  Also joining us is Eric Goldstein, Executive Assistant Director for Cybersecurity at  CISA, sharing their CIRCIA Notice of Proposed Rulemaking. Selected Reading Pentagon lays out strategy to improve defense industrial base cybersecurity (The Record) Massachusetts Health Insurer Data Breach Impacts 2.8 Million (SecurityWeek) American fast-fashion firm Hot Topic hit by credential stuffing attacks (Security Affairs) Cisco Warns of Password Spraying Attacks Exploiting VPN Services (Cybersecurity News) AI abuse and misinformation campaigns threaten financial institutions (Help Net Security) Federal Elections Commission Considers Regulating AI (BankInfo Security) Thread Hijacking: Phishes That Prey on Your Curiosity (Krebs on Security) The slow death of X-Twitter is measured in disasters like the Baltimore bridge collapse (Vox) Share your feedback. We want to ensure that you are getting the most out of the podcast. Please take a few minutes to share your thoughts with us by completing our brief listener survey as we continually work to improve the show.  Want to hear your company in the show? You too can reach the most influential leaders and operators in the industry. Here's our media kit. Contact us at cyberwire@n2k.com to request more info. The CyberWire is a production of N2K Networks, your source for strategic workforce intelligence. © 2023 N2K Networks, Inc.

In this week's show Patrick Gray and Adam Boileau discuss the week's security news. They talk about: Thought eels were slippery? Check out AnyDesk's PR! Why Microsoft's 365 is a nightmare to secure Cloudflare's needlessly hostile blog post US Government introduces “Disneyland ban” for spyware peddlers Much, much more… This week's feature guest is Eric Goldstein, the executive assistant director for cybersecurity at CISA. He's joining the show to talk about CISA's demand that US government agencies unplug their Ivanti appliances. He also chimes in on why the US government is so rattled by Volt Typhoon and addresses a recent report from Politico that claims CISA's Joint Cyber Defense Collaborative is a bit of a shambles. This week's sponsor guest is Dan Guido from Trail of Bits. He joins us to talk about their new Testing Handbook. Trail of Bits does a bunch of audit work and they've committed to trying to make bug discovery a one time thing – if you find that bug once, you shouldn't have to manually find it on another client engagement. Semgrep for the win! Show notes AnyDesk initiates extensive credentials reset following cyberattack | Cybersecurity Dive AnyDesk says software ‘safe to use' after cyberattack Former CIA officer who gave WikiLeaks state secrets gets 40-year sentence Arrests in $400M SIM-Swap Tied to Heist at FTX? – Krebs on Security Microsoft Breach — What Happened? What Should Azure Admins Do? | by Andy Robbins | Feb, 2024 | Posts By SpecterOps Team Members Cloudflare hit by follow-on attack from previous Okta breach | Cybersecurity Dive Thanksgiving 2023 security incident US announces visa restriction policy targeting spyware abuses Announcement of a Visa Restriction Policy to Promote Accountability for the Misuse of Commercial Spyware - United States Department of State Deputy Prime Minister hosts first global conference targeting ‘hackers for hire' and malicious use of commercial cyber tools - GOV.UK New Google TAG report: How Commercial Surveillance Vendors work A Startup Allegedly ‘Hacked the World.' Then Came the Censorship—and Now the Backlash | WIRED American businessman settles hacking case in UK against law firm Crime bosses behind Myanmar cyber ‘fraud dens' handed over to Chinese government Another Chicago hospital announces cyberattack Deepfake scammer walks off with $25 million in first-of-its-kind AI heist | Ars Technica As if 2 Ivanti vulnerabilities under exploit weren't bad enough, now there are 3 | Ars Technica Two new Ivanti bugs discovered as CISA warns of hackers bypassing mitigations Agencies using vulnerable Ivanti products have until Saturday to disconnect them | Ars Technica The far right is scaring away Washington's private hacker army - POLITICO Our thoughts on AIxCC's competition format | Trail of Bits Blog How CISA can improve OSS security | Trail of Bits Blog Securing open-source infrastructure with OSTIF | Trail of Bits Blog Announcing the Trail of Bits Testing Handbook | Trail of Bits Blog 30 new Semgrep rules: Ansible, Java, Kotlin, shell scripts, and more | Trail of Bits Blog Publishing Trail of Bits' CodeQL queries | Trail of Bits Blog The Unguarded Moment (2002 Digital Remaster) - YouTube Boy Swallows Universe | Official Trailer | Netflix - YouTube

In this week's show Patrick Gray and Adam Boileau discuss the week's security news. They talk about: Thought eels were slippery? Check out AnyDesk's PR! Why Microsoft's 365 is a nightmare to secure Cloudflare's needlessly hostile blog post US Government introduces “Disneyland ban” for spyware peddlers Much, much more… This week's feature guest is Eric Goldstein, the executive assistant director for cybersecurity at CISA. He's joining the show to talk about CISA's demand that US government agencies unplug their Ivanti appliances. He also chimes in on why the US government is so rattled by Volt Typhoon and addresses a recent report from Politico that claims CISA's Joint Cyber Defense Collaborative is a bit of a shambles. This week's sponsor guest is Dan Guido from Trail of Bits. He joins us to talk about their new Testing Handbook. Trail of Bits does a bunch of audit work and they've committed to trying to make bug discovery a one time thing – if you find that bug once, you shouldn't have to manually find it on another client engagement. Semgrep for the win! Show notes AnyDesk initiates extensive credentials reset following cyberattack | Cybersecurity Dive AnyDesk says software ‘safe to use' after cyberattack Former CIA officer who gave WikiLeaks state secrets gets 40-year sentence Arrests in $400M SIM-Swap Tied to Heist at FTX? – Krebs on Security Microsoft Breach — What Happened? What Should Azure Admins Do? | by Andy Robbins | Feb, 2024 | Posts By SpecterOps Team Members Cloudflare hit by follow-on attack from previous Okta breach | Cybersecurity Dive Thanksgiving 2023 security incident US announces visa restriction policy targeting spyware abuses Announcement of a Visa Restriction Policy to Promote Accountability for the Misuse of Commercial Spyware - United States Department of State Deputy Prime Minister hosts first global conference targeting ‘hackers for hire' and malicious use of commercial cyber tools - GOV.UK New Google TAG report: How Commercial Surveillance Vendors work A Startup Allegedly ‘Hacked the World.' Then Came the Censorship—and Now the Backlash | WIRED American businessman settles hacking case in UK against law firm Crime bosses behind Myanmar cyber ‘fraud dens' handed over to Chinese government Another Chicago hospital announces cyberattack Deepfake scammer walks off with $25 million in first-of-its-kind AI heist | Ars Technica As if 2 Ivanti vulnerabilities under exploit weren't bad enough, now there are 3 | Ars Technica Two new Ivanti bugs discovered as CISA warns of hackers bypassing mitigations Agencies using vulnerable Ivanti products have until Saturday to disconnect them | Ars Technica The far right is scaring away Washington's private hacker army - POLITICO Our thoughts on AIxCC's competition format | Trail of Bits Blog How CISA can improve OSS security | Trail of Bits Blog Securing open-source infrastructure with OSTIF | Trail of Bits Blog Announcing the Trail of Bits Testing Handbook | Trail of Bits Blog 30 new Semgrep rules: Ansible, Java, Kotlin, shell scripts, and more | Trail of Bits Blog Publishing Trail of Bits' CodeQL queries | Trail of Bits Blog The Unguarded Moment (2002 Digital Remaster) - YouTube Boy Swallows Universe | Official Trailer | Netflix - YouTube

A major ransomware gang is taken down in an international sweep. CISA and the WaterISAC respond to the Aliquippa cyberattack. Attacks against infrastructure operators hit business systems. Qlik Sense installations are hit with Cactus ransomware. Researchers discover a Google Workspace vulnerability. A hacktivist auxiliary compromises a Russian media site.  In an exclusive interview, Eric Goldstein, Executive Assistant Director at CISA, describes their new Secure by Design Alerts program launching today. Tim Starks from the Washington Post shares some insights on the latest legislation dealing with section 702 surveillance. And security teams need not polish up that resumé after a breach. CyberWire Guest We have 2 guests today. First, Dave recently spoke with Eric Goldstein, Executive Assistant Director at CISA, about their new Secure by Design Alerts program that launched today.  And, Tim Starks from the Washington Post's Cybersecurity 202 stopped by to share some insight into some of the latest trending cybersecurity headlines.  For links to all of today's stories check out our CyberWire daily news briefing: https://thecyberwire.com/newsletters/daily-briefing/12/226 Selected Reading Police dismantle ransomware group behind attacks in 71 countries (Bleeping Computer) Ransomware group dismantled in Ukraine in a major international operation supported by Eurojust and Europol (Eurojust) Water and Wastewater Cybersecurity (CISA) (TLP:CLEAR) Water Utility Control System Cyber Incident Advisory: ICS/SCADA Incident at Municipal Water Authority of Aliquippa (Water ISAC) Iran hits Pennsylvania water utility. (CyberWire) North Texas water utility serving 2 million hit with cyberattack (The Record)  DAIXIN TEAM GROUP CLAIMED THE HACK OF NORTH TEXAS MUNICIPAL WATER DISTRICT (Security Affairs) Slovenian power company hit by ransomware (Help Net Security) Qlik Sense Exploited in Cactus Ransomware Campaign (Arctic Wolf) Qlik Sense Enterprise for Windows - New Security Patches Available Now (Qlik) DeleFriend: Severe design flaw in Domain Wide Delegation could leave Google Workspace vulnerable for takeover (Hunters)  Researchers Claim Design Flaw in Google Workspace Puts Organizations at Risk (Dark Reading) Use IAM securely (Google) 

Apple patches actively exploited iOS 17 vulnerability. Qakbot's survival of a major takedown. BADBOX puts malware into the device supply chain. LoonyTunables and a privilege-escalation risk. Scattered Spider believed responsible for cyberattack against Clorox. Sony discloses information on its data breach. In today's Threat Vector segment, Chris Tillett, Senior Research Engineer at Palo Alto Networks and member of the Advisory Board at Titaniam Labs, joins host David Moulton to delve inside the mind of an insider threat. Dave Bittner sits down with Eric Goldstein, Executive Assistant Director at CISA, to discuss shared progress against the ransomware threat. And the Kremlin tightens control over the Russian information space. On this segment of Threat Vector, Chris Tillett, Senior Research Engineer at Palo Alto Networks and member of the Advisory Board at Titaniam Labs, joins host David Moulton to delve inside the mind of an insider threat. For links to all of today's stories check out our CyberWire daily news briefing: https://thecyberwire.com/newsletters/daily-briefing/12/191 Selected reading. Apple emergency update fixes new zero-day used to hack iPhones (BleepingComputer) Apple releases iOS 17.0.3 to address iPhone 15 overheating issues (Computing)  Apple Warns of Newly Exploited iOS 17 Kernel Zero-Day (SecurityWeek)  Qakbot-affiliated actors distribute Ransom Knight malware despite infrastructure takedown (Cisco Talos Blog) HUMAN Disrupts Digital Supply Chain Threat Actor Scheme Originating from China (HUMAN) Trojans All the Way Down: BADBOX and PEACHPIT (Human) 'Looney Tunables' Bug Opens Millions of Linux Systems to Root Takeover (Dark Reading) Looney Tunables: New Linux Flaw Enables Privilege Escalation on Major Distributions (The Hacker News)  Clorox Security Breach Linked to Group Behind Casino Hacks (Bloomberg)  Clorox Warns of a Sales Mess After Cyberattack (Wall Street Journal) Sony confirms data breach impacting thousands in the U.S. (BleepingComputer) Sony sent data breach notifications to about 6,800 individuals (Security Affairs)  Russian Offensive Campaign Assessment, October 4, 2023 (Institute for the Study of War) Learn more about your ad choices. Visit megaphone.fm/adchoices

Kicking off the 20th Annual Cybersecurity Awareness Month, we welcome back to the podcast Eric Goldstein, Executive Assistant Director for Cybersecurity for the Department of Homeland Security's Cybersecurity and Infrastructure Security Agency (CISA). He shares insights on the exciting new cybersecurity public awareness campaign just launched, “Secure Our World”. It features simple ways to protect yourself, your family, and your business from online threats. Eric also shares some key takeaways from the recent headline making MOVEit attack impacting 60M+ individuals and sparking a new $10M bounty from the US State Department for the Clop ransomware group. And we dive into CISA's Strategic Plan which focuses on how we will collectively reduce risk and build resilience to cyber and physical threats to the nation's infrastructure. This is an awesome episode you won't want to miss! https://www.cisa.gov/secure-our-world Eric Goldstein, Executive Assistant Director for Cybersecurity, CISA Eric Goldstein serves as the Executive Assistant Director for Cybersecurity for the Department of Homeland Security's Cybersecurity and Infrastructure Security Agency (CISA) as of February 19, 2021. In this role, Goldstein leads CISA's mission to protect and strengthen federal civilian agencies and the nation's critical infrastructure against cyber threats. Previously, Goldstein was the Head of Cybersecurity Policy, Strategy, and Regulation at Goldman Sachs, where he led a global team to improve and mature the firm's cybersecurity risk management program. He served at CISA's precursor agency, the National Protection and Programs Directorate,from 2013 to 2017 in various roles including Policy Advisor for Federal Network Resilience, Branch Chief for Cybersecurity Partnerships and Engagement, Senior Advisor to the Assistant Secretary for Cybersecurity, and Senior Counselor to the Under Secretary. At other points in his career, Goldstein practiced cybersecurity law at an international law firm, led cybersecurity research and analysis projects at a federally-funded research and development center, and served as a Fellow in Advanced Cyber Studies at the Center for Strategic and International Studies, among other roles. He is a graduate of the University of Illinois at Urbana-Champaign, the Georgetown University School of Public Policy, and Georgetown University Law Center. For links and resources discussed in this episode, please visit our show notes at https://www.forcepoint.com/govpodcast/e253

Cyber threats trending from East Asia. The Lazarus Group is suspected in the CoinEx crypto theft. Pig butchering, enabled by cryptocurrency. BlackCat is active against Azure storage. a Ukrainian view of cyber warfare. A US-Canadian water commission deals with a ransomware attack. Eric Goldstein from CISA shares insights on cyber threats from China. Neil Serebryany of Calypso explains the policies, tools and safeguards in place to enable the safe use of generative AI. And more details emerge in the Las Vegas casinos' ransomware incidents. Danny Ocean, call your office. For links to all of today's stories check out our CyberWire daily news briefing: https://thecyberwire.com/newsletters/daily-briefing/12/178 Selected reading. Sophistication, scope, and scale: Digital threats from East Asia increase in breadth and effectiveness (Microsoft Security Compliance and Identity) Evidence points to North Korea in CoinEx cryptocurrency hack, analysts say (Record)  CoinEx invites hackers to negotiate after suffering data breach (The Times of India BlackCat ransomware hits Azure Storage with Sphynx encryptor (BleepingComputer) MGM websites up, but reservation systems still affected by hack (Las Vegas Review-Journal) The chaotic and cinematic MGM casino hack, explained (Vox) Massive MGM and Caesars Hacks Epitomize a Vicious Ransomware Cycle (WIRED) US-Canada water commission confirms 'cybersecurity incident' (Register)  Ukraine's Fusion of Cyber and Kinetic Warfare: Illia Vitiuk's Stand Against Russian Cyber Operations (AFCEA International) Learn more about your ad choices. Visit megaphone.fm/adchoices

Phishing for Zimbra credentials. PlayCrypt ransomware described. The Cuba ransomware group adopts new tools. #NoFilter. Cyber criminals threaten security researchers. Our guest is Kevin Paige from Uptycs with thoughts on the Blackhat conference. Eric Goldstein, Executive Assistant Director at CISA joins us discussing next steps on the Secure by Design journey. And Russian disinformation takes on "Anglo-Saxonia." For links to all of today's stories check out our CyberWire daily news briefing: https://thecyberwire.com/newsletters/daily-briefing/12/158 Selected reading. Mass-spreading campaign targeting Zimbra users (We Live Security) PlayCrypt Ransomware Group Wreaks Havoc in Campaign Against Managed Service Providers (Adlumin SaaS Security) Cuba Ransomware Deploys New Tools: Targets Critical Infrastructure Sector in the U.S. and IT Integrator in Latin America (BlackBerry) NoFilter Attack: Sneaky Privilege Escalation Method Bypasses Windows Security (The Hacker News) Cyber security researchers become target of criminal hackers (Financial Times) Britain plotting to assassinate pro-Russian leaders in Africa, says Moscow (The Telegraph)  Ukraine at D+540: Russification and disinformation. (CyberWire) 

Cybersecurity and Infrastructure Security Agency execs like to say security is so important they put it in their name twice. Now that same rationale is the impetus behind CISA's first-ever cybersecurity strategic plan for 2024 to 2026. Security is so important CISA says it needs its own strategic plan to position itself to better handle the ever-changing cyber challenges. Eric Goldstein, CISA's executive assistant director for cybersecurity, tells Federal News Network's Jason Miller about how the new cyber strategic plan provides a roadmap for transformative change. Learn more about your ad choices. Visit podcastchoices.com/adchoicesSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Cybersecurity and Infrastructure Security Agency execs like to say security is so important they put it in their name twice. Now that same rationale is the impetus behind CISA's first-ever cybersecurity strategic plan for 2024 to 2026. Security is so important CISA says it needs its own strategic plan to position itself to better handle the ever-changing cyber challenges. Eric Goldstein, CISA's executive assistant director for cybersecurity, tells Federal News Network's Jason Miller about how the new cyber strategic plan provides a roadmap for transformative change. Learn more about your ad choices. Visit megaphone.fm/adchoices

A man who oversaw food service for New York City schools was convicted in a bribery case that picked apart how chicken tenders riddled with bone and bits of metal were served for months in the nation's biggest public school system. Former city Department of Education official Eric Goldstein and three men who founded a school food vendor — Blaine Iler, Michael Turley and Brian Twomey — were found guilty of bribery, conspiracy and other charges after a monthlong trial. It delved into school menus, from yogurt parfait to ravioli. And the trial gave jurors a stomach-churning look at what some students and school staffers encountered when a brand called Chickentopia turned up on their plates in 2016 and 2017. “Our children depended on nutritious meals served in schools and, instead, got substandard food products containing pieces of plastic, metal and bones,” Brooklyn-based U.S. Attorney Breon Peace said in a statement. As head of the school system's Office of School Support Services from 2008 to 2018, Goldstein oversaw functions including the food service operation, known as SchoolFood. Iler, Twomey and Turley had a company, SOMMA Food Group, with its eye on the New York City school system. Around the same time, the three men and Goldstein formed another company to import grass-fed beef. Prosecutors argued that the venture amounted to a conduit for paying Goldstein off. According to prosecutors, Iler, Turley and Twomey paid thousands of dollars to Goldstein and his divorce lawyer. Meanwhile, Goldstein helped ensure that the school system bought Chickentopia items and other SOMMA products, sometimes on a fast track. Then, in September 2016, SOMMA hit a snag: A school system employee choked on a bone in a supposedly boneless Chickentopia chicken tender and needed the Heimlich maneuver, according to documents presented at the trial. For a time, the schools stopped serving the company's chicken tenders. They were allowed back two months later — a day after the SOMMA founders agreed to pay Goldstein $66,670 and gave him their shares of the beef business. Goldstein then signed off on reintroducing Chickentopia products, prosecutors said. The tenders reappeared. So did complaints about foreign objects in them. SchoolFood ultimately ditched SOMMA products in April 2017, according to prosecutors. This article was provided by The Associated Press.

A joint warning on IDOR vulnerabilities. IcedID's BackConnect protocol evolves over one year. Cl0p claims to have accessed data from another Big Four accounting firm. Ransomware victims increased significantly in 2023. Cyberattacks support influence operations. Deputy National Security Advisor for Cyber and Emerging Technology Anne Neuberger joins us to discuss the Biden Administration's recent cyber initiatives. Eric Goldstein, Executive Assistant Director at CISA, looks at cybersecurity performance goals. And spelling counts. For links to all of today's stories check out our CyberWire daily news briefing: https://thecyberwire.com/newsletters/daily-briefing/12/143 Selected reading. Preventing Web Application Access Control Abuse (Joint Cybersecurity Advisory: ACSC, NSA, CISA)  Inside the IcedID BackConnect Protocol (Part 2) (Team Cymru)  Deloitte denies Cl0p data breach impacted client data in wake of MOVEit attack (ITPro)  Ransomware Report: Q2 2023 (ReliaQuest) Kenya ICT minister admits cyber-attack on eCitizen portal, insists data secure (The East African) Anonymous Sudan: the group behind recent anti-Kenya cyberattacks (TechCabal)  Kenya President Ruto to skip Russia-Africa Summit (The East African) UK accidentally sent military emails meant for US to Russian ally (POLITICO)

Eric Goldstein is the Executive Assistant Director for Cybersecurity of the U.S. Cybersecurity and Infrastructure Security Agency, having served previously as Global Head of Cybersecurity Policy Strategy and Regulation at Goldman Sachs, where he led development of the firm's cybersecurity risk management program, and in cybersecurity positions in DHS, as well as practicing cybersecurity law in the private sector. David Kris, Lawfare Contributor and former Assistant Attorney General for the National Security Division, and Bryan Cunningham, Lawfare Contributor and Executive Director of the University of California, Irvine's Cybersecurity Policy & Research Institute, sat down with Eric to talk about all things cybersecurity, including the U.S. National Cybersecurity Strategy and U.S. government cyber lanes in the road. Eric also discusses ransomware and what it's like for a lawyer to serve in an operational position. Support this show http://supporter.acast.com/lawfare. Hosted on Acast. See acast.com/privacy for more information.

LockBit 3.0 claims responsibility for Nagoya ransomware attack. Charming Kitten sighting. Spyware infested apps found in Google Play. Threats and risks to electric vehicle charging stations. Solar panels and cyberattacks. Dave Bittner speaks with Eric Goldstein, Executive Assistant Director for Cybersecurity at CISA, to talk about CISA's effort for companies to build safety into tech products.Rick Howard sits down with Clarke Rodgers of AWS to discuss the mechanics of CISO roundtables. And Hacktivist auxiliaries remain active in Russia's hybrid war. For links to all of today's stories check out our CyberWire daily news briefing: https://thecyberwire.com/newsletters/daily-briefing/12/127 Selected reading. Pro-Russian hackers target Port of Nagoya, disrupting loading of Toyota parts (The Japan Times)  Port of Nagoya resumes operations later than planned after Russian hack (The Japan Times)  Ransomware Halts Operations at Japan's Port of Nagoya (Dark Reading)  Nagoya Port Faces Disruption After Ransomware Attack (Infosecurity Magazine)  Welcome to New York: Exploring TA453's Foray into LNKs and Mac Malware | Proofpoint US (Proofpoint) Two spyware tied with China found hiding on the Google Play Store (Pradeo) EV Charger Hacking Poses a ‘Catastrophic' Risk (WIRED)  Exploited Solar Power Product Vulnerability Could Expose Energy Organizations to Attacks (SecurityWeek) The Continued Expansion of Cyber Incidents by Non-State Actors in the War in Europe (OODA Loop).   Russian railway site allegedly taken down by Ukrainian hackers (Record)

Barracuda Networks urges replacement of their gear. Fractureiser infects Minecraft mods. ChatGPT sees a court date over hallucinations and defamation. Asylum Ambuscade engages in both crime and espionage. The US delivers Ukraine Starlink connectivity. DDoS attacks hit the Swiss parliament's website. My conversation with Eric Goldstein, Executive Assistant Director for Cybersecurity at CISA. Our guest is Delilah Schwartz from Cybersixgill discussing how the Dark Web is evolving with new technologies like ChatGPT. And BEC crooks see their day in court. For links to all of today's stories check out our CyberWire daily news briefing: https://thecyberwire.com/newsletters/daily-briefing/12/111 Selected reading. Barracuda Email Security Gateway Appliance (ESG) Vulnerability (Barracuda) CVE-2023-2868 (MITRE) ACT government falls victim to Barracuda's ESG vulnerability (CSO Online) CVE-2023-2868: Total Compromise of Physical Barracuda ESG Appliances (Rapid7) CVE-2023-2868 Detail (National Institute of Standards and Technology) Infected Minecraft Mods Lead to Multi-Stage, Multi-Platform Infostealer Malware (Bitdefender) New Fractureiser malware used CurseForge Minecraft mods to infect Windows, Linux (BleepingComputer) IN THE SUPERIOR COURT OF FULTON COUNTY (Superior Court of Fulton County) OpenAI Hit With First Defamation Suit Over ChatGPT Hallucination (Bloomberg Law)

Babuk source code provides criminal inspiration. CISA and FBI release a joint report on PaperCut. There are more bad bots out there than anyone would like. Phishing-as-a-service tools in the C2C market. CISA's Eric Goldstein advocates the adoption of strong controls, defensible networks and coordination of strategic cyber risks. Our cyberwire producer Liz Irvin speaks with Crystle-Day Villanueva, Learning and Development Specialist for Lumu Technologies. And KillNet's short-lived venture, with a dash of regret. For links to all of today's stories check out our CyberWire daily news briefing: https://thecyberwire.com/newsletters/daily-briefing/12/92 Selected reading. Babuk code used by 9 ransomware gangs to encrypt VMWare ESXi servers (Bleeping Computer) Ransomware actors adopt leaked Babuk code to hit Linux systems (Decipher) Hypervisor Ransomware | Multiple Threat Actor Groups Hop on Leaked Babuk Code to Build ESXi Lockers (SentinelOne) Malicious Actors Exploit CVE-2023-27350 in PaperCut MF and NG (CISA) CVE-2023-27350 Detail (NIST) Proofpoint Emerging Threats Rules (Proofpoint) 2023 Imperva Bad Bot Report (Imperva) New phishing-as-a-service tool “Greatness” already seen in the wild (Cisco Talos) Ukraine at D+442: Russians say the Ukrainian counteroffensive has begun. (CyberWire)

Patch Tuesday update. Another commercial surveillance company is outed. Voice security and the challenge of fraud. CISA updates its Zero Trust Maturity Model. Effects of the US intelligence leaks. Our guest Eric Goldstein, Executive Assistant Director for Cybersecurity at CISA, outlines CISA's role in the cybersecurity community. André Keartland of Netsurit makes the case for DevSecOps. Russian cyber auxiliaries believed responsible for disrupting the Canadian PM's website. For links to all of today's stories check out our CyberWire daily news briefing: https://thecyberwire.com/newsletters/daily-briefing/12/70 Selected reading. Patch Tuesday overview. (CyberWire) DEV-0196: QuaDream's “KingsPawn” malware used to target civil society in Europe, North America, the Middle East, and Southeast Asia (Microsoft Threat Intelligence)  Threat Report on the Surveillance-for-Hire Industry (Meta) Sweet QuaDreams: A First Look at Spyware Vendor QuaDream's Exploits, Victims, and Customers (The Citizen Lab) Voice Intelligence and Security Report (Pindrop) CISA Releases updated Zero Trust Maturity Model (Cybersecurity and Infrastructure Security Agency) CISA Releases Zero Trust Maturity Model Version 2 (Cybersecurity and Infrastructure Security Agency CISA) A leak of files could be America's worst intelligence breach in a decade (The Economist) Interagency Effort Assessing Impact of Leaked Documents, Strategizing Way Forward (U.S. Department of Defense) What we know about the Pentagon document leak (Axios) The ongoing scandal over leaked US intel documents, explained (Vox) Pentagon leak threatens Biden's foreign policy doctrine ahead of overseas trip (Axios) Schumer calls for all-senator briefing on leaked Ukraine documents (The Hill) The key countries and revelations from the Pentagon document leak (Washington Post)  Exclusive: Leaked U.S. intel document claims Serbia agreed to arm Ukraine (Reuters)  Up to 50 UK special forces present in Ukraine this year, US leak suggests (the Guardian) Egypt denies leak about supplying Russia with 40,000 rockets (Al Jazeera) DDoS attacks block PM Trudeau's web site (IT World Canada)

This episode of the Cyberlaw Podcast is dominated by stories about possible cybersecurity regulation. David Kris points us first to an article by the leadership of the Cybersecurity and Infrastructure Security Administration in Foreign Affairs. Jen Easterly and Eric Goldstein seem to take a tough line on “Why Companies Must Build Safety Into Tech Products.“ But for all the tough language, one word, “regulation,” is entirely missing from the piece. Meanwhile, the cybersecurity strategy that the White House has been reportedly drafting for months seems to be hung up over how enthusiastically to demand regulation. All of which seems just a little weird in a world where Republicans hold the House. Regulation is not likely to be high on the GOP to-do list, so calls for tougher regulation are almost certainly more symbolic than real. Still, this is a week for symbolic calls for regulation. David also takes us through an National Telecommunications and Information Administration (NTIA) report on the anticompetitive impact of Apple's and Google's control of their mobile app markets. The report points to many problems and opportunities for abuse inherent in their headlock on what apps can be sold to phone users. But, as Google and Apple are quick to point out, they do play a role in regulating app security, so breaking the headlock could be bad for cybersecurity. In any event, practically every recommendation for action in the report is a call for Congress to step in—almost certainly a nonstarter for reasons already given. Not to be outdone on the phony regulation beat, Jordan Schneider and Sultan Meghji explore some of the policy and regulatory proposals for AI that have been inspired by the success of ChatGPT. The EU's AI Act is coming in for lots of attention, mainly from parts of the industry that want to be regulation-free. Sultan and I trade observations about who'll be hollowed out first by ChatGPT, law firms or investment firms. Sultan also tells us why the ION ransomware hack matters. Jordan and Sultan find a cybersecurity angle to The Great Chinese Balloon Scandal of 2023. And I offer an assessment of Matt Taibbi's story about the Hamilton 68 “Russian influence” reports. If you have wondered what the fuss was about, do not expect mainstream media to tell you; the media does not come out looking good in this story. Unfortunately for Matt Taibbi, he does not look much better than the reporters his story criticizes. David thinks it is a balanced and moderate take, for which I offer an apology and a promise to do better next time.

This episode of the Cyberlaw Podcast is dominated by stories about possible cybersecurity regulation. David Kris points us first to an article by the leadership of the Cybersecurity and Infrastructure Security Administration in Foreign Affairs. Jen Easterly and Eric Goldstein seem to take a tough line on “Why Companies Must Build Safety Into Tech Products.“ But for all the tough language, one word, “regulation,” is entirely missing from the piece. Meanwhile, the cybersecurity strategy that the White House has been reportedly drafting for months seems to be hung up over how enthusiastically to demand regulation. All of which seems just a little weird in a world where Republicans hold the House. Regulation is not likely to be high on the GOP to-do list, so calls for tougher regulation are almost certainly more symbolic than real. Still, this is a week for symbolic calls for regulation. David also takes us through an National Telecommunications and Information Administration (NTIA) report on the anticompetitive impact of Apple's and Google's control of their mobile app markets. The report points to many problems and opportunities for abuse inherent in their headlock on what apps can be sold to phone users. But, as Google and Apple are quick to point out, they do play a role in regulating app security, so breaking the headlock could be bad for cybersecurity. In any event, practically every recommendation for action in the report is a call for Congress to step in—almost certainly a nonstarter for reasons already given. Not to be outdone on the phony regulation beat, Jordan Schneider and Sultan Meghji explore some of the policy and regulatory proposals for AI that have been inspired by the success of ChatGPT. The EU's AI Act is coming in for lots of attention, mainly from parts of the industry that want to be regulation-free. Sultan and I trade observations about who'll be hollowed out first by ChatGPT, law firms or investment firms. Sultan also tells us why the ION ransomware hack matters. Jordan and Sultan find a cybersecurity angle to The Great Chinese Balloon Scandal of 2023. And I offer an assessment of Matt Taibbi's story about the Hamilton 68 “Russian influence” reports. If you have wondered what the fuss was about, do not expect mainstream media to tell you; the media does not come out looking good in this story. Unfortunately for Matt Taibbi, he does not look much better than the reporters his story criticizes. David thinks it is a balanced and moderate take, for which I offer an apology and a promise to do better next time.

On Episode 24 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the January 2023 issue of Stroke: “Covert Brain Infarction as a Risk Factor for Stroke Recurrence in Patients With Atrial Fibrillation” and “Subarachnoid Hemorrhage During Pregnancy and Puerperium.” She also interviews Dr. Georgios Tsivgoulis about his article “Clinical, Neuroimaging, and Genetic Markers in Cerebral Amyloid Angiopathy-Related Inflammation: A Systematic Review and Meta-Analysis.” Dr. Negar Asdaghi:         Let's start with some questions. 1) When during pregnancy is an intracranial aneurysm at the highest risk of rupture? 2) What does the presence of covert brain infarcts mean in the setting of atrial fibrillation? 3) And, finally, how is the inflammatory form of cerebral amyloid angiopathy different from the classic CAA form, and why is it important to differentiate between the two? We'll be answering these questions and much more in today's podcast. We're covering the latest in cerebrovascular disorders, and this is the best in Stroke. Stay with us. Welcome back to another issue of the Stroke Alert Podcast. My name is Negar Asdaghi. I'm an Associate Professor of Neurology at the University of Miami Miller School of Medicine and your host for the monthly Stroke Alert Podcast. Together with my co-editors, Drs. Nastajjia Krementz and Eric Goldstein, here's our article selection for the month of January. Symptomatic intracerebral hemorrhage is a feared complication of reperfusion therapies in acute stroke, so there's a lot of interest in looking for predictors of development of this complication, especially when you're making decisions for pursuing endovascular therapy. For many years now, we've known about some of these predictors, such as presence of a large infarct core and high blood glucose levels. But in the recent years, other radiographic markers of tissue viability, such as a poor collateral status and unfavorable venous outflow profile, have been shown to be predictors of post-reperfusion hemorrhagic transformation. In this issue of the journal, we learn about another imaging marker that can potentially predict parenchymal hemorrhage occurrence post-endovascular therapy, which is high hypoperfusion intensity ratio, or HIR, as measured by perfusion imaging. What is HIR? It's a long name for a simple ratio that can easily be measured by dividing the volume of tissue with Tmax delay of over 10 seconds to the volume of tissue with Tmax delays of over 6 seconds. Simply put, Tmax 10 divided by Tmax 6. These volumes, as you know, are typically provided to us by almost all post-processing perfusion softwares, and so this ratio can be easily calculated in the acute setting. So, in this paper led by Dr. Tobias Faizy from University Medical Center in Hamburg and colleagues, we learned that higher hypoperfusion intensity ratios are strongly associated with parenchymal hemorrhage occurrence after endovascular therapy. So, in summary, HIR, that is a quantitative ratio, can be used as a marker to risk stratify patients that are undergoing endovascular therapy in terms of helping us predicting the risk of development of intracerebral hemorrhage after reperfusion therapies. In a separate study in this issue of the journal, we read a very interesting paper titled "Anti-Epileptic Drug Target Perturbation and Intracranial Aneurysm Risk." How are intracranial aneurysms even related to anti-epileptic drugs? Well, first of all, it's been known for a long time based on genome-wide association studies that there are multiple common genes that are associated with increased risk of intracranial aneurysm development. Now, some of the largest genetic studies to date have shown pleiotropy between genetic causes of development of intracranial aneurysms and genes encoding targets for anti-epileptic drugs. Now that's a fascinating finding because finding commonalities between these genes may help find new treatment targets for intracranial aneurysms. So, in this paper in this issue of the journal, the investigators from the University Medical Center in Utrecht found an association in the expression of anti-epileptic drug target gene CNNM2 and intracranial aneurysm risk. They found that certain anti-epileptic drugs, such as phenytoin, valproic acid, and carbamazepine, that are expected to lower CNNM2 levels in the blood may subsequently lead to a lower risk of development of intracranial aneurysms. And, of course, a reasonable follow-up study to this would be to investigate whether persons exposed to these anti-epileptic drugs have indeed a lower risk of unruptured intracranial aneurysms and subarachnoid hemorrhage, and how variation in CNNM2 expression can lead to development of aneurysms. Bottom line, CNNM2 may be a relevant drug target for treatment of cerebral aneurysms. As always, I encourage you to review these papers in detail in addition to listening to our podcast today. My guest on the podcast today is the Chairman of Neurology at the University of Athens, Dr. Georgios Tsivgoulis. He joins me all the way from Greece to talk about cerebral amyloid angiopathy-related inflammation, or CAA-ri. He's a remarkable researcher, and I can say with absolute confidence that we cannot find a better summary of this very tough topic elsewhere. He ends the interview with an intriguing account of the early description of dementia in Greek mythology. But first, with these two articles. What are covert brain infarcts, or CBIs? Are these the John Wick or the James Bond of the stroke world? After all, they operate undercover. They're ominous and attack without warning. That's probably why they're also called silent infarcts. Now, whatever we call them, we need to know how prevalent they are and what does their presence actually mean. Let's dive into this topic. For at least two centuries, if not longer, we've known about covert brain infarcts. Early description of these lesions is credited to Amédée Dechambre, a medical intern at Salpêtrière Hospital in Paris who noted that there are strokes that can cause symptoms like hemiplegia, but also strokes that are asymptomatic, or so he thought at the time. In the modern times, while we agree with our pathology forefathers that CBIs are different from symptomatic strokes, we also know that they are not entirely asymptomatic. The symptoms can be subtle and tend to sneak up on the patient, but what is clear is that amassing of covert brain infarcts results in an overall decline in cerebrovascular reserve of the brain. With the advent of neuroimaging, we now know that CBIs are age-dependent and prevalent, seen in almost 10 to 30% of even healthy adults, but much more prevalent in those with vascular risk factors, and they can be caused by nearly the entire spectrum of neurovascular disease, including large vessel, small vessel disorders, cardioembolism, and others. Now, how do these covert infarcts catch up in those with atrial fibrillation? Neuroimaging studies have shown that patients with A-fib, especially those untreated, have a higher percentage of embolic-appearing CBIs, and conversely, those with embolic formed pattern of CBIs are more likely to have undiagnosed A-fib. So the question is, what's the significance of CBI in those with confirmed A-fib? In this issue of the journal, Dr. Do Yeon Kim from Seoul National University and colleagues help us answer this question using the EAST-AF, which stands for East Asian Ischemic Stroke Patients With Atrial Fibrillation Study. So, the paper included over 1300 patients with A-fib and first-ever stroke without a prior history of TIA or stroke. And then they categorized these patients into those who had evidence of CBI on neuroimaging and those who didn't. So, what did they find? Forty-two percent of patients with A-fib and first-ever stroke had evidence of covert brain infarcts on neuroimaging. Let's think about it for a moment. These patients presented with what was thought to be their first-ever stroke, not knowing they already had some in their brain. Now, what makes things really worse is that over a quarter of these subjects had more than just one covert infarct. Not surprisingly, those with CBI tended to be older, had higher blood pressure, and had worse white matter hyperintensity burden. This is kind of expected and also not expected was the fact that most of these covert infarcts were actually embolic in pattern. Over 60% of them were embolic. Another 14% of cases had combined embolic and non-embolic-appearing CBIs. Now, overall, the one-year incidence of ischemic stroke and all-cause mortality was higher in those that had CBIs at baseline. When they started looking at the specific patterns of CBIs, those embolic-appearing CBIs had a threefold higher risk of recurrent ischemic stroke, whereas those with non-embolic-appearing covert infarcts had oddly a higher all-cause mortality rate but not recurrent ischemic stroke. And finally, just briefly, the authors noted that the addition of CBIs to the classic CHA2DS2-VASc score didn't meaningfully otherwise statistically improve the scoring metrics, so they left it at that. So, the take-home message is that 42% of A-fib patients presenting with first-ever stroke actually had prior strokes without even knowing based on this study. And most of these strokes were embolic-appearing, and these covert brain infarcts can be used as predictors of future clinical strokes in this population. Strokes should be the last thing to worry about when we think of pregnancy. In the United States, around 30 in 100,000 women, unfortunately, experienced a stroke during pregnancy, and between 6 to 8 in 100,000 deliveries are complicated by subarachnoid hemorrhage. What's the most common cause of pregnancy-associated subarachnoid hemorrhage? In the general population, close to 80% of subarachnoid hemorrhage cases are aneurysmal. Is this true for the pregnant population as well? And importantly, what's the contemporary incidence trend, risk factors, and outcomes of pregnancy-related subarachnoid hemorrhage? In this issue of the journal, Dr. Korhonen and Petra [Ijäs] and their colleagues from the Departments of Neurology and Obstetrics and Gynecology at Helsinki University Hospital will give us the answers to some of these questions through a nationwide population-based study in Finland. So, they looked at over one and a half million pregnant women who gave birth during a 30-year time period between 1987 to 2016. Subarachnoid hemorrhage was identified through appropriate ICD codes and then further adjudicated based on confirmatory information, including neuroimaging and data from lumbar puncture. A total of 57 cases of pregnancy-related subarachnoid hemorrhage was identified in this paper. The mean age of women was 33, ranging from 23 to 45, and the clinical presentation was typical for subarachnoid hemorrhage, including thunderclap headache and mild neurological symptoms. So, what did they find? So, first off, in terms of general observations, the overall incidence rate of pregnancy-related subarachnoid hemorrhage in this study was 3 over 100,000 deliveries. This is almost half the incidence rate reported from the nationwide registries in the United States. Seventy-seven percent of pregnancy-related subarachnoid hemorrhage cases were aneurysmal, so very similar to the general population. The other 23% were non-aneurysmal cases, but it's important to note that 40% of those non-aneurysmal cases also had vascular etiologies, so etiologies such as moyamoya syndrome, postpartum angiopathy, AVM, to name a few. Like non-pregnant patients with subarachnoid hemorrhage, the aneurysmal cases were sicker patients in general. They had a lower GCS at presentation, higher Hunt and Hess scores, and required more ICU admissions. The next finding is very important because it actually shows that development of subarachnoid hemorrhage during pregnancy significantly impacted obstetrical care. A total of 66% of women with subarachnoid hemorrhage during pregnancy ended up having a C-section and a high percentage of these cesarean sections were actually elective. This is in contrast with subarachnoid hemorrhages in the postpartum period where 67% of women had spontaneous vaginal deliveries. The other important finding of the paper was really highlighting the differences between pregnancy-related aneurysmal versus non-aneurysmal subarachnoid hemorrhages. We already talked about how, in general, aneurysmal cases had more severe neurological presentations, so, not surprisingly, they also had worse outcomes with a mortality rate of 16% for the aneurysmal subarachnoid hemorrhage cases, and only 68% of women with pregnancy-related aneurysmal subarachnoid hemorrhage reached a favorable outcome, which was defined in this study as modified Rankin Scale of 0 to 2. Other important differences included the fact that the incidence of aneurysmal subarachnoid hemorrhage increased towards the end of pregnancy and was highest in the third trimester. This ties in with the findings from prior studies all indicating that rupture of an aneurysm is most common in the third trimester. By contrast, the incidence of non-aneurysmal subarachnoid hemorrhage peaked in the second trimester in this study. And finally, in terms of risk factors, first let's talk about age. The incidence rate of pregnancy-associated subarachnoid hemorrhage increased with age of the mother. So, in this study, there were no cases noted amongst women aged below 20 years of age to an incident rate of 12 per 100,000 deliveries among women aged 40 years or over. So that's a fourfold increase from the overall incidence rate of pregnancy-related subarachnoid hemorrhage, and very important point that we learned from this paper. Apart from age, smoking beyond 12 weeks of gestation and hypertension were also independent factors associated with pregnancy-related subarachnoid hemorrhage. So, overall, hypertension, smoking are bad and are significant risk factors for pregnancy-related subarachnoid hemorrhage. And if we have to remember just one thing from this paper, let it be this one: The rupture of an aneurysm is most common in the third trimester of pregnancy. Cerebral amyloid angiopathy, or CAA, is an important cause of intracranial hemorrhage and refers to deposition of β-amyloid fibrils in the wall of the small- and medium-sized cerebral blood vessels, mostly involving cortical and leptomeningeal arteries. It is believed that the deposition of β-amyloid results in architectural disruption of the blood vessels, which then leads to perivascular leakage. That's the pathophysiological mechanism behind the development of cerebral microbleeds. And this process, of course, can cause frank vascular rupture resulting in cortical intracerebral hemorrhage or development of high-convexity subarachnoid hemorrhages. It is important to note that varying amounts of perivascular inflammation, that is inflammation surrounding β-amyloid-laden blood vessels, may be present in some CAA cases, rendering them the designation of inflammation-related CAA. However, frank vasculitic destruction of the vessel wall, such as what is found in amyloid-β-related angiitis, or ABRA, and primary angiitis of the central nervous system, is usually absent in most CAA-related inflammation cases. How these entities are best defined, diagnosed, and treated is subject of intense research. In this issue of the journal, in the study titled "Clinical, Neuroimaging, and Genetic Markers in CAA-Related Inflammation," Dr. Georgios Tsivgoulis and colleagues take us through a systematic review and meta-analysis of published studies of patients with CAA-related inflammation. I am joined today by Dr. Tsivgoulis himself to discuss this paper. He's a Professor of Neurology and Chairman of the Second Department of Neurology at the University of Athens School of Medicine. Dr. Tsivgoulis is the residency program director and the director of cerebrovascular fellowship program with extensive research and expertise in the field of stroke. Good morning, Georgios, and welcome to our podcast. Dr. Georgios Tsivgoulis: Good morning, Negar. I'm delighted to be here and delighted to present our findings, on behalf of all our co-authors. Dr. Negar Asdaghi:         Thank you very much for being here and congrats again on the paper. So, Georgios, let's start with this interest that's going on with using clinical and radiographic features to make the diagnosis of CAA-related inflammation in contrast to moving ahead and performing brain biopsy. Can you please start us off with a brief review of the newly proposed clinico-radiographic criteria for this condition, please? Dr. Georgios Tsivgoulis: Yes. As you mentioned, Negar, CAA-ri is a distinct, however, rare subset of cerebral amyloid angiopathy. Firstly, Greenberg and the Boston group published in Neurology in 2007 a paper highlighting that a diagnosis of a probable CAA-ri patient could be made on the basis of characteristic clinical and neuroimaging findings without requiring a biopsy. Following this observation, Chung and colleagues in 2010, in a seminal paper in JNNP, proposed the first diagnostic criteria for probable and definite CAA-ri. For the definite diagnosis, besides the typical clinical presentation with headache, encephalopathy, focal neurological signs and seizures, and the characteristic neuroimaging findings with T2 or FLAIR hyperintense asymmetric white matter lesions complicated with microbleeds and leptomeningeal or parenchymal gadolinium enhancement, and histopathological confirmation with amyloid deposition within cortical leptomeningeal vessels associated with perivascular, transmural or intramural inflammation was also required. The latest criteria developed in 2015 by Auriel and colleagues that were published in JAMA Neurology using a validation study modified the current criteria for the diagnosis of CAA-ri. In this paper, the author supported the use of empirical immunosuppressive therapy, avoiding brain biopsy, for patients meeting the criteria proposed for probable CAA-ri. They suggested that a brain biopsy should be considered in empirically treated patients who failed to respond to corticosteroid therapy within three weeks. The criteria by Auriel and colleagues are widely applicable in everyday clinical practice, and we also use this criteria for the inclusion of studies in our current meta-analysis. I would like to highlight for our audience that the latest criteria for CAA-ri were published in 2015 by Auriel and colleagues. However, these are different for the criteria for cerebral amyloid angiopathy than the latest criteria were published in 2022 in Lancet Neurology, OK? Dr. Negar Asdaghi:         Georgios, that was a great start for this interview. You had mentioned a lot of information here. I just want to highlight what you just said. So, we are using for this meta-analysis, the latest criteria in CAA-related inflammation published in JAMA by Auriel and colleagues. That's slightly different than, we're not referring to the 2022 criteria of cerebral amyloid angiopathy. It's an important distinction. We're going to talk about this a little more as we go through the interview, but I want to come back to your current paper and start from there. Can you please tell us about the importance of this paper, why doing a meta-analysis was important in your view, and tell us a little bit about the studies that were included in your paper? Dr. Georgios Tsivgoulis: Yes, thank you for that question. CAA-ri is an increasingly recognized entity since the recent diagnostic criteria by Auriel and colleagues published in 2015. In collaboration with the greater availability of the high-resolution MR, we can have now a reliable non-invasive diagnosis of possible or probable CAA-ri, avoiding the risk of brain biopsy. However, I need to highlight that the early diagnosis remains a great challenge for the clinicians and neurologists. Searching the literature, we observe that there is scarce data regarding the prevalence of the distinct clinical, neuroimaging, and genetic markers among patients diagnosed with CAA-ri. We believe that pooling all this information in the current meta-analysis would be very helpful for every clinician, increasing a comprehensive understanding of this rare cerebrovascular disorder. Consequently, we conducted this meta-analysis including 21 studies that recruited a total of 378 patients with CAA-ri. Our study involved only 4 prospective and 17 retrospective hospital-based cohorts of patients diagnosed with CAA-ri based on autopsy or biopsy or on the recent Auriel diagnostic criteria that do not require autopsy or biopsy. Due to limited data in the literature regarding this entity, we had to include only small cohort studies with at least five patients in our meta-analysis. We excluded case reports and case series with less than five patients. This is, by far, the largest available sample of CAA-ri patients in the literature. Dr. Negar Asdaghi:         OK, great. So, let me just recap this, more so for myself. So, we have 21 studies, and you excluded studies that included less than 5 patients. So, practically speaking, case reports. Dr. Georgios Tsivgoulis: Yes, and single-case reports. Dr. Negar Asdaghi:         Yes. And practically speaking, of the total number of patients that are included in this meta-analysis, you have 378 cases, and basically the diagnosis of CAA-related inflammation was either based on the newly proposed criteria or based on biopsy-confirmed or autopsy cases. Dr. Georgios Tsivgoulis: Which is the standard criteria. Dr. Negar Asdaghi:         So, now, I'm dying to ask you about these clinical and radiographic characteristics of patients with CAA-related inflammation in this meta-analysis. Dr. Georgios Tsivgoulis: The mean age of patients in the included studies was approximately 72 years old, and there was no obvious gender predominance. Fifty-two percent of the patients were of female sex. In our study, 70% of the included patients presented with cognitive decline, which was the most common neurological manifestation, while 50% of the total sample had focal neurological signs and 54% encephalopathy presentation. Symptoms such as headache and seizures were less common, 37 and 31% respectively. With regard to the radiological findings, hyperintense T2 FLAIR white matter lesions were very, very common in 98% of our patients, and they were also complicated with lobar cerebral microbleeds, with a prevalence of 96%, and these two were, by far, the most prevalent neuroimaging findings, that white matter hyperintensities coupled with a cerebral microbleed. The pooled prevalence rates of gadolinium-enhanced lesions was 54%, and also the prevalence of cortical superficial siderosis was 51%, which is also very high in this cohort of patients with CAA-ri. Dr. Negar Asdaghi:         OK. So many of the features Georgios said, you mentioned, from presence of white matter hyperintense lesions on T2 FLAIR to presence of cortical microbleeds or superficial siderosis, these features are also seen in patients with cerebral amyloid angiopathy. What are some of the important differentiating features between the two conditions? Dr. Georgios Tsivgoulis: Yes, this is an excellent clinical question. First of all, the lower age threshold for CAA-ri is 40 years old, whereas in cerebral amyloid angiopathy, the lower age threshold is 50 years. So, patients who are younger than 50 years can be diagnosed with CAA-ri, but they cannot be diagnosed with CAA. Another issue is that comparing the result of this meta-analysis with another recent meta-analysis focusing on CAA, on cerebral amyloid angiopathy, that our international multi-collaborative group published in Stroke in 2002, we also evaluated the presence of clinical phenotypes and radiological markers among patients with cerebral amyloid angiopathy. We have documented that transient focal neurological episodes are much more common in patients with cerebral amyloid angiopathy in contrast to patients with CAA-ri. These episodes, which are called TFNEs, transient focal neurological episodes, are attributed to cortical subarachnoid hemorrhage or cortical superficial siderosis. So, I think this is another important clinical distinction. The most important, however, differentiating features between the two entities are neuroimaging markers, in specific, in particular, T2 FLAIR hyperintense unifocal or multifocal lesions with mass effect. These are the most prevalent neuroimaging features among patients with CAA-ri, but they're very seldomly described in patients with cerebral amyloid angiopathy, in patients with CAA. Another characteristic neuroimaging finding very indicative of the inflammation is the leptomeningeal or parenchymal gadolinium enhancement. This finding has been very rarely described in patients with non-inflammatory cerebral amyloid angiopathy. So, the clinical distinction is not so solid. However, the neuroimaging distinction would provide us with very strong information that can help us differentiate these two conditions. Dr. Negar Asdaghi:         Excellent points, I have to say, golden points, not just excellent points. I'm going to try to recap this and see if I understood it correctly. So, for our listeners, we have two conditions that potentially have many common points. One is the cerebral amyloid angiopathy, and the second one, which is obviously the subject of this interview, is cerebral amyloid angiopathy-related inflammation. The most important differentiating factors between the two are actually the neuroimaging features, as Georgios mentioned. So, the first feature that was mentioned is presence of T2 FLAIR hyperintense lesions. Some of them are large and have actually mass effects. This feature is rarely seen in patients with CAA, and it's an important radiographic factor that is seen in patients with CAA-related inflammation. The second distinguishing feature was leptomeningeal enhancement, again, rarely seen in non-inflammatory CAA, but was seen in a significant proportion of patients with CAA-related inflammation. These were the neuroimaging features. You also mentioned two other factors. The median age of CAA-related inflammation was lower than CAA. That can be helpful. And also the entity of transient focal neurological episodes, or TFNE, is rarely seen in inflammatory cases of CAA, whereas it is described in cases with cerebral amyloid angiopathy and mostly related to development of either cortical subarachnoid hemorrhage or cortical superficial siderosis. I think I got this all, correct? Dr. Georgios Tsivgoulis: Excellent. Dr. Negar Asdaghi:         All right, so let's come now to the genetics of CAA. The apolipoprotein E gene is associated with the presence of amyloid angiopathy and development of lobar intracerebral hemorrhage, and we've learned about this in cases with cerebral amyloid angiopathy. Is there an association with ApoE, and did you find anything in this meta-analysis? Dr. Georgios Tsivgoulis: Another very exciting question. In 2007, there was a first report that the apolipoprotein ε4 homozygosity may be considered a risk factor for CAA-ri, and there was a strong correlation reporting a high prevalence of 77% of this apolipoprotein ε4 alleles among patients with CAA-ri. To justify this correlation, the hypothesis was that an underlying pathogenic mechanism, which increases the amyloid-β deposition and has a pro-inflammatory effect, may be suspected as the cause of this disorder. The largest, however, prospective cohort of CAA-ri patients conducted by Antolini and colleagues and was published in 2021 in Neurology, reported a much lower prevalence of apolipoprotein ε4 carriers accounting for 37%, 23% heterozygotes and 14% homozygotes. So, we also documented a pool prevalence of apolipoprotein ε4 homozygosity of 34%. So, we did not confirm the initial finding of 77%. However, in our meta-analysis, the homozygosity was 34%, and we need to have a cautious interpretation of these results because data is limited, and we need larger future population-based studies and in larger cohorts to evaluate the prevalence rate of these specific genetic markers. So, we can confirm an association between apolipoprotein ε4 homozygosity, however not as strong as originally reported in 2007. Dr. Negar Asdaghi:         OK. So, Georgios, thank you. And again, very important factor to keep in mind for our clinicians listening in. Unfortunately, based on what you mentioned, we don't have yet a genetic marker to, for sure, tell us if we're dealing with CAA-related inflammation, yes or no, as you mentioned. Just to recap, earlier on, there was studies to suggest a very strong association between apolipoprotein ε4 homozygosity and CAA-related inflammation. But later on, this was not confirmed by subsequent studies, and in your meta-analysis, you found 34% ApoE ε4 homozygosity amongst patients with CAA-related inflammation and could not confirm that original high association. OK, so with all of that, it's a lot of information. I have to go to the next question regarding controversies involving the levels of Aβ40, Aβ42, and P-tau proteins in CSF in the setting of CAA-related inflammation. Can you please tell us more about these biomarkers? Dr. Georgios Tsivgoulis: Yes. The overlap of Alzheimer's disease and CAA can be attributed to the coexistence of some degree of cerebrovascular amyloid deposition and amyloid plaque pathology, which is very common. And, of course, the evaluation of amyloid and tau proteins in CSF is of high significance for the prognosis and the evolution of CAA patients. In our previous review, we have summarized the literature and noticed that CSF concentrations of Aβ40 and, secondarily, Aβ42 were much lower in patients with cerebral amyloid angiopathy compared with Alzheimer's disease. Total tau and phospho-tau CSF levels were comparable to healthy controls in CAA and lower than patients with Alzheimer's disease. Moving now to CAA-ri, there were scarce data about these biomarkers amongst CAA-ri patients. The majority of the relevant studies have found relatively low levels of Aβ42 and Aβ40 in the CSF and high levels of P-tau. In the present meta-analysis, the pooled means of biomarker levels were based on the findings of only two studies with heterogeneity, and these limit substantially the validity of our observations. However, they confirm the previous reports indicating, as I said before, but I would like to repeat, low levels of Aβ42 and Aβ40 in the CSF and high levels of P-tau. Dr. Negar Asdaghi:         Perfect. So, thank you, Georgios. I'm going to recap what you said. So, we're talking about CSF biomarkers, and first what you mentioned is going back to the original studies concentrated on using these biomarkers as ways of differentiating between cerebral amyloid angiopathy and Alzheimer's disease. And very briefly, to recap what you said, in general, the levels of Aβ40 and, secondarily, Aβ42 was found to be much lower than the Alzheimer's levels in patients with CAA. Now coming to the inflammatory form of CAA, what you mentioned and what you found in this meta-analysis, practically speaking, confirmed that the levels of Aβ40 and Aβ42 in CSF are low and the levels of P-tau are high in this condition as well. So, one thing I want to ask as a secondary question to that is, that it sounds like these biomarkers are more or less similar in CAA and CAA -related inflammation, not that different. Is that correct? Dr. Georgios Tsivgoulis: It's absolutely correct. And I would also like to highlight a major limitation of the meta-analysis that we had available data from only two studies to pool the mean of these CSF biomarker levels. So, these results need to be acknowledged with caution, and we would love to repeat our meta-analysis after the publication of more studies and prospective cohorts measuring the CSF biomarkers in patients with CAA-ri. Dr. Negar Asdaghi:         OK. So, again, important to note, as you mentioned, that there's heterogeneity in data because of just paucity of information on this, but as we stand today, the biomarkers won't really help us in terms of differentiating between the two conditions that are CAA or CAA-related inflammation. And so, I think I've learned a lot from this interview myself, but I think we have to just talk briefly about the available therapies for CAA-related inflammation. Dr. Georgios Tsivgoulis: Yes. In our meta-analysis, we sought to summarize the available information regarding different therapeutic strategies and outcomes among CAA-ri patients. Our results supported our clinical experience indicating that corticosteroids represent the first-line treatment in these patients' outlook. Steroids have been associated with clinical and radiological improvement of the primary disease episode and decreased risk of subsequent relapses in patients with CAA-ri. Additional immunosuppressive therapies, including cyclophosphamide, mycophenolate mofetil, azathioprine, IVIG, or rituximab, have been also reported as adjunct therapies in selected cases with a more severe course of the disease. However, this is another limitation that needs to be acknowledged. That data regarding the treatment and the outcomes are limited and heterogeneous, which prevented us from drawing robust conclusions using a meta-analytical approach. And we believe that we need future cohort studies with prospective data validation in order to generate a proposal for a therapeutic algorithm management in these cases. Dr. Negar Asdaghi:         Thank you, Georgios. So, we have a condition that is now being more and more recognized. We now have criteria based on clinical and radiographic presentation features of patients that might help us with this diagnosis to differentiate it from cerebral amyloid angiopathy. And in terms of therapies, the idea is that the most studied drug is really just first-line therapy, that's corticosteroids. And then there's positive data regarding use of all other forms of immunosuppression, including, as you mentioned, cyclophosphamide, rituximab, and oral agents such as mycophenolate mofetil or azathioprine. We have limited information about those, but I want to highlight something you actually mentioned earlier on in the interview, which is the field is moving towards making these diagnoses based on clinical features and radiographic features that you had highlighted and actually giving patients immunosuppression early on and only move on to a biopsy if the patient had failed these therapies for a period of time, which you mentioned three weeks. So, I think it's important for us as clinicians to keep this evolving criterion and recommendations in mind. And before we end, I want to ask you a hypothetical question, Georgios. In your opinion, what's an ideal randomized trial for CAA-related inflammation in the future? Dr. Georgios Tsivgoulis: I think before going to the randomized, the ideal randomized trial for CAA-ri, and designing this trial, we need much more information regarding the underlying pathophysiological mechanisms. There are many unanswered questions. What is the diagnostic value of CSF biomarkers such as amyloid, we discussed earlier, and tau protein? And, of course, what is the value of CSF and the amyloid-β autoantibodies, if there is any? What is the value of genetic markers such as apolipoprotein E genotype and a correlation with the co-existing inflammation in CAA-ri? However, I don't want to defer this question. So, a typical answer would be that with regard to the ideal patients, we would want a young patient without comorbidities after the first manifestation of CAA-ri who has shown a good clinical and radiological response to corticosteroids in order to define the best second-line therapy. However, before answering all these questions in a clinical trial, if we can, I think that we need to understand the CSF and genetic biomarkers in order to uncover mechanisms regarding pathophysiology that can help us to design more targeted clinical trials studying novel disease-modifying treatments. Dr. Negar Asdaghi:         Thank you. Dr. Georgios, it's been a pleasure having you on the podcast, and I can say we've learned a lot. We look forward to having you back here and talk about that hypothetical randomized trial, and I'm sure one day hopefully will happen in our lifetime. Thank you for being here. Dr. Georgios Tsivgoulis: Thank you. Thank you for having me. It was a pleasure. Dr. Negar Asdaghi:         Thank you. Homer, the legendary Greek poet, described a case of dementia in his seminal work, The Odyssey, in the late eighth century before Christ. He described the cognitive decline of Odysseus's father, King Laertes. The detailed account of the king's mental decline, loss of short-term memory with retention of long-term memory combined with his depression and despair over the loss of his son, is dramatically accurate for a nearly 3,000-year-old description of dementia. Before I ended the interview, I had to use this opportunity to ask Georgios about lessons learned from ancient Greeks and this seemingly timeless disease. Dr. Georgios Tsivgoulis: Thank you for this question. King Laertes was indeed Odysseus's father, and it's a great paradigm describing dementia. However, the ancient history of dementia may be separated according to the Greek philosopher Posidonius in two periods. The first period is called dementia appearing due to old age, which is called in Greek, eros. And the second one is dementia appearing in other ages and mainly due to other reasons, called morosis. Posidonius of Rhodes was a Greek stoic philosopher of the second first century BC who strongly believed and suggested that morosis, which is that dementia appearing in younger ages due to other disorders, should be treated immediately after its onset. So, if I would like to end this podcast, I would just suggest that CAA-ri could be classified as morosis according to Posidonius. And what we could learn is that the early diagnosis is essential since the prompt initiation of corticosteroids should not be unreasonably delayed. Dr. Negar Asdaghi:         And this concludes our podcast for the January 2023 issue of Stroke. Please be sure to check this month's table of contents for the full list of publications, including a series of Focused Updates on post-stroke neurological recovery, from management of post-stroke attention deficit, neglect and apraxia to post-stroke memory decline. And with this, we end the start of our 2023 podcast series. Like all new things, a new beginning can come with new directions, and sometimes a new direction is all that we need. After all, as the legend has it, it was a direction of that falling apple back in the year 1666 that gave Isaac Newton the idea of the universal law of gravitation. Now, Isaac Newton has, without a doubt, given science some of its biggest discoveries in mathematics, physics, and astronomy. But most may not know that Newton had a pretty rough start in life. A January-born premature baby, he was thought not to survive the first few days of life. Newton had a difficult childhood, and at the age of 16, he was pulled out of school by his family and forced to become a farmer, a job he didn't like and he was miserably bad at. So, as we start a new year, let's remember that even the smartest people are not good at everything, and it does take time to find one's passion in life. Now, while things may not always be clear, what is clear is that a great way to find that center of gravity is, as always, staying alert with Stroke Alert. This podcast is produced by Wolters Kluwer and supported by the editorial team of Stroke. Our Stroke Alert podcast and production staff includes Danielle Cross, Eric Goldstein, Nastajjia Krementz, Ishara Ratnayaka, Erinn Cain, Rebecca Seastrong, and Negar Asdaghi. This program is copyright of the American Heart Association, 2023. The opinions expressed by speakers in this podcast are their own and not necessarily those of the editors or of the American Heart Association. For more, visit AHAjournals.org.

Chuck Kirlin sits down with Eric Goldstein, President and CEO, King of Prussia District. https://visitkop.com/

Learn more about your ad choices. Visit megaphone.fm/adchoices

On this edition of Cats at Night, John Catsimatidis is joined by John Keane, Dr. Peter Michalos, Eric Goldstein, Burt Flickinger & Lee Rizzuto. Learn more about your ad choices. Visit megaphone.fm/adchoices

On Episode 23 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the December 2022 issue of Stroke: “Direct, Indirect, and Combined Extracranial-to-Intracranial Bypass for Adult Moyamoya Disease” and “Contemporary Incidence and Burden of Cerebral Venous Sinus Thrombosis in Children of the United States.” She also interviews Drs. Koji Tanaka and Andrew Demchuk about article “Significance of Baseline Ischemic Core Volume on Stroke Outcome After EVT in Patients Age ≥75 Years.” Dr. Negar Asdaghi:         Let's start with some questions. 1) Is direct bypass better than indirect bypass in preventing the future risk of vascular events in adult patients with moyamoya disease? 2) What is the contemporary incidence of cerebral venous sinus thrombosis in the pediatric population? 3) And finally, is endovascular therapy beneficial for patients presenting with a large ischemic core? We have the answers and much more in today's podcast. You're listening to the Stroke Alert Podcast, and this is the best in Stroke. Stay with us. Welcome back to another issue of the Stroke Alert Podcast. My name is Negar Asdaghi. I'm an Associate Professor of Neurology at the University of Miami Miller School of Medicine and your host for the monthly Stroke Alert Podcast. In our final podcast for the year, I'm thrilled to announce that Drs. Nastajjia Krementz and Eric Goldstein have joined our podcast as assistant editors to help us cover the latest and the best in the field of cerebrovascular disorder. And together, here's our article selection to close the year. As part of our Advances in Stroke, in the article titled "Focus on Anticoagulation for Valvular Heart Disease With and Without Atrial Fibrillation," we get an update on current evidence from randomized controlled trials on the use of direct oral anticoagulants or vitamin K antagonists in patients with valvular heart disease that are mechanical valves, moderate to severe mitral stenosis, or bioprosthetic valves from the perspective of stroke physicians. What that means is that data from randomized trials was analyzed based on whether the patient had a prior history of stroke or TIA. In this review, we learned that direct oral anticoagulants may be used in patients with bioprosthetic valves who have atrial fibrillation, although DOACs have never been shown to be superior over vitamin K antagonists. We also learned that vitamin K antagonists should be used in patients with rheumatic moderate to severe mitral valve stenosis or patients with mechanical valves with or without atrial fibrillation and, of course, sometimes during the first few months after either surgical or transcatheter aortic valve replacement in patients without atrial fibrillation. And finally, patients with bioprosthetic valves without AFib don't have any other indications to be treated with anticoagulants should be treated with antiplatelet monotherapy in the long run. In a separate article in this issue of the journal, from Dr. Yang and colleagues from China, we learn about the pathophysiology of radiation-induced brain injury with special attention to radiation-induced vasculopathy. These investigators show that hyperactivity of notch signaling pathway that in normal state is essential in vascular morphogenesis and maintenance of arterial identity actually results in abnormal accumulation and disturbance of vascular smooth muscle cells, resulting in arterial muscularization and arterial dysfunction seen in radiation-induced vasculopathy. What's interesting is that inhibition of the notch signaling pathway in their study resulted not only in a measurable reduction in radiation induced vasculopathy, but also an overall improvement in radiation-induced brain injury as measured by the cognitive function of the mice exposed to radiation in their study. This study takes us a step closer to possible therapeutic options for radiation-induced vasculopathy and radiation-induced brain injury using compounds that can potentially inhibit the notch signaling pathway. As always, I encourage you to review these articles in detail in addition to listening to our podcast. For our interview today, I have a special guest who's not only a prominent researcher and a pioneer in the field of acute stroke therapies, but also, he's an experienced educator who has trained many of the current leaders in the field of vascular neurology and has been influential in shaping the careers of many vascular neurology fellows over the years. Take a listen. Dr. Andrew Demchuk:   I've had the privilege of training fellows. I've been the director since 2004, and we've trained close to 100 fellows in Calgary over 20-some years now. Really, it's frankly an honor and privilege to be able to do that. These individuals come from all over the world. They're here to dedicate themselves to learning a subspecialty really, really well, and it's just a fantastic experience to interact with them all and all their cultures to help them learn those things, and doing it in a fun, enjoyable, comprehensive way. Dr. Negar Asdaghi:         And those are the words of Dr. Andrew Demchuk, who's incidentally my own vascular fellowship director as well. Andrew joins me all the way from Canada to talk about his latest paper on the very hot topic of outcomes of endovascular therapy in patients presenting with a large ischemic core. And true to form, he's accompanied by one of his current vascular fellows. The interview is definitely worth the wait after we review these two articles. Most of us have heard of the term "moyamoya." First described in Japan in 1950s, the term refers to occlusion or stenosis of the terminal portion of the internal carotid artery and is associated with dilated collateral vessels of the proximal middle cerebral artery. These collaterals have a hazy appearance on angiography resembling the puff of smoke, which is Japanese for "moyamoya." Moyamoya is categorized into two broad categories of moyamoya syndrome and moyamoya disease. Syndrome refers to the situations where the occlusion occurs due to another condition. Conditions such as Down syndrome, sickle cell disease, neurofibromatosis type one have all been recognized as associated with moyamoya syndrome. Of course, moyamoya syndrome can occur due to a secondary insult to the blood vessels, anything from radiation vasculopathy, as we reviewed earlier in the podcast, to autoimmune vasculitis, or even good old advanced intracranial atherosclerosis involving the distal ICA region can cause moyamoya syndrome. Now, in contrast to moyamoya syndrome, the term "moyamoya disease" is reserved for individuals with no vascular risk factors or known moyamoya predisposing conditions other than, of course, some potential genetic factors. The most recognized genetic association for moyamoya disease is polymorphism in the ring finger protein 213, or RNF213, gene on chromosome 17. But we also have to keep in mind that the majority of moyamoya disease patients have no identified genetic abnormalities. So, moyamoya is truly a complex condition, and the physicians have to navigate the many possible etiologies that may cause or be associated with this condition. But when it comes to treatment options, we're really limited here. Antiplatelets are generally used and have been shown to reduce mortality in both moyamoya disease and syndrome, and especially cilostazol, which is the favorite antiplatelet therapy of our own assistant editor, Eric, has been shown to be significantly associated with increased survival rate in patients with moyamoya disease. Eric really wanted me to talk about a recently published study out of Korea, which included over 9,000 patients, and that showed that patients treated with cilostazol had a better survival rate than any other antiplatelet therapies. Apart from antiplatelet therapies, medical treatment includes optimizing all other vascular risk factors, which, as we mentioned, are rarely present in this population. So, it all comes down to most cases, at some point, needing surgical treatment, with bypass surgery being the most commonly surgical intervention for this population. Three flavors of bypass are used: indirect, direct, or combination of the two. Indirect bypasses are kind of like long-term investments where the surgeon moves vascular tissue to the surface of the brain in hopes of promoting angiogenesis. Several procedures, such as performing multiple burr holes, pial synangiosis, dural inversion, or omental transposition, among other methods, are used. And broadly speaking, we can think of indirect procedures as angiogenesis-dependent methods, the effect of which takes months to recognize and, in general, are thought to be more efficacious in the pediatric population than the adult population. The direct bypass, in contrast, commonly referred to as extracranial-to-intracranial, or ECIC, bypass, is more of an immediate reward where the surgeon stitches a vessel directly from a donor extracranial branch, typically the superficial temporal artery, to a recipient artery, typically the middle cerebral artery, to provide a direct anastomosis between the two vessels. There are technical variations, of course, especially with regards to the number of donors and recipient arteries used, but essentially this method is an angiogenesis-independent method that results in a quicker revascularization, but it's unclear if this strategy is long lasting. A combination of direct and indirect bypass can also be used. So, the question is, which method is better, especially in the adult population? In this issue of the journal, in the study titled "Direct, Indirect, and Combined ECIC Bypass for Adult Moyamoya Disease," Dr. Nickalus Khan and colleagues report on a meta-analysis and systematic review of those with adult moyamoya disease who underwent either direct, indirect, or a combination bypass. The main study question was whether there's a difference in the rates of early ischemic or hemorrhagic strokes, defined as strokes occurring within 30 days of bypass, or late strokes, defined as strokes occurring after 30 days of bypass, in this population when comparing the different surgical techniques. They also compared the "favorable" outcome rate; however, this outcome was defined in each study between the various broad techniques of direct, indirect, and combined bypass. So, with that, let's take a very quick look at their methodology. They screened more than 4,000 articles and identified 143 articles for their pooled analysis, the majority of articles being from Eastern Asian-based regions, and they had close to 4,000 combined, 4,000 direct, and 4,000 indirect bypass procedures for this analysis. And they had an average follow-up of over three and a half years. So, this is a great sample size for this large, pooled analysis. But they also performed a smaller meta-analysis where they were much more stringent with article selection, excluding pediatric papers, excluding articles containing only one surgical modality, or articles with insufficient outcome data. So, for that meta-analysis, they only had 43 articles qualified and were included in that meta-analysis. So, what did they find? In the larger pooled analysis, a significant benefit in favor of both direct and combined bypass techniques were noted in reduction of early and late ischemic strokes and late intracerebral hemorrhage. Also, a higher rate of that sort of vague favorable outcome was noted with both the direct or combined methods as compared to when indirect bypass techniques were used alone. So, everything in the large, pooled analysis pointed towards the direct bypass or combined technique performing better than all indirect bypass techniques, with only one exception, which was a lower incidence of early intracerebral hemorrhage rate in indirect bypass cases. So, that's one point to keep in mind. The second point was when they compared combined techniques to direct bypass. Overall, these procedures had more or less the same outcomes with the exception that the rate of late ischemic stroke was lower in the combined group than the direct bypass group. So, this is sort of the overall summary of what they found in that large, pooled analysis. When they were much more stringent with their selection criteria, focusing on the smaller meta-analysis portion of the study, what they found was that in the short term, there were no differences in outcomes of any type of stroke between any of these methods. So, basically, people, regardless of the type of bypasses they received, did the same with regards to the risk of intracerebral hemorrhage and ischemic stroke recurrence within the first 30 days after the bypass. But for the late stroke outcomes, whether ischemic or hemorrhagic, those with indirect bypass were nearly twofold more likely to develop late stroke after 30 days compared to those who've undergone the direct bypass. A similar pattern was found comparing combined bypass versus indirect bypass, in general, beyond the 30 days, with combined bypass doing better. Comparing direct versus combined bypass showed no difference regardless of timeframe. So, in summary, overall, it appears that combined or direct bypasses may be the best surgical strategies for treatment of adult patients with moyamoya disease. This study, of course, has many limitations, as does any meta-analysis, but most importantly, the authors focused on moyamoya disease in their analysis. It is presumed, but really unclear if patients with moyamoya syndrome would respond similarly to these different techniques. So, the question is, what surgical procedure are you using at your institution for treatment of adult moyamoya disease patients? And, of course, Eric wanted me to ask if your antiplatelet of choice is cilostazol for this population, yes or no. Leave us your comments, and let us know. Venous sinus thrombosis, or CVST, is a less common form of stroke most commonly affecting women and young individuals. In our past podcast, we've covered many aspects of CVST, especially when it comes to therapy with anticoagulation, anticoagulant of choice, and duration of therapy. In the October podcast, we reviewed a systematic review and meta-analysis comparing direct oral anticoagulants to vitamin K antagonists in the adult patients with CVST. But there are many aspects of this disease that we have not yet covered. For instance, you may ask, how common is this relatively uncommon condition? In the adult population, the incidence of CVST varies depending on the age of individuals studied, and ranges between 1.3 to 2.7 per 100,000 in women between the ages of 31 to 50, which is the adult population at highest risk for this disease. But the incidence of CVST, for instance, in the pediatric population is largely unknown. Some studies suggested an incidence rate of 0.67 per 100,000 in the pediatric population. That's roughly less than half the incidence rate in young female adults, but these reports are from the 1990s and are likely very outdated. Nowadays, many of the pediatric conditions, especially infectious conditions, that can predispose children to CVST are more readily diagnosed and treated. On the other hand, we now perform a lot more imaging than 30 years ago. Our neuroimaging modalities are more accurate, so we are more likely to diagnose CVST than before. So, the question is, what is the contemporary incidence of pediatric cerebral venous sinus thrombosis? In this issue of the journal, in the study titled "Contemporary Incidence and Burden of Cerebral Venous Sinus Thrombosis in Children of the United States," Dr. Fadar Otite and colleagues conducted a retrospective analysis of the New York State Inpatient Database, or SID, from 2006 to 2018, and the National Kids Inpatient Database, referred to as KID, from 2006 to 2019, for all hospitalized CVST cases. KID is the largest publicly-available pediatric inpatient care database in the United States, containing about 3 million pediatric discharges. They included over 700 hospitalized CVST cases from the SID database and 6,100 hospitalizations from the national KID database for the current analysis. And here's what they found. Number one, in terms of significant risk factors associated with CVST, congenital circulatory system anomalies, infections, head trauma, dehydration, and anemia were amongst the top CVST risk factors in the pediatric population. So that's very good to know. Number two, in terms of presentation, seizures were the most common presentation among all pediatric age groups, with close to half of infants with CVST presenting with seizures. Number three, in terms of outcomes, the rate of mortality was twice higher in the infants group as compared to all other age groups. And finally, the overall incidence of CVST, which was the main question of the paper, in this population was 1.1 per 100,000 per year, with a peak incidence during infancy of 6.4 per 100,000 per year. Interestingly, incident admissions also increased annually by 3.8% throughout the study period, which was close to 15 years in this paper. And the national burden of hospitalization dramatically and exponentially grew during the study period. So, here are the top three points from this study. Point one: Girls included less than half of all admissions nationally and statewide, and the overall burden of CVST was higher in boys than girls. That's a dramatic difference between the pediatric and adult populations. Point two: Incidence of CVST in infants was higher than five times that of other age groups at 6.4 per 100,000 compared to overall incidence in children, which was 1.1 per 100,000 people per year. Mortality was also two times higher in infants than in any other age group. And finally, point 3, incident admissions and national burden of hospitalization have dramatically increased over time, but it remains unclear whether true incidence has been on the rise or if simply more cases are recognized nowadays due to heightened awareness of this condition and our advanced neuroimaging capabilities. This study, of course, has some limitations. Data was only obtained on patients admitted, so many patients that may have had CVST but not admitted are not captured in this database. So, in summary, CVST can have catastrophic consequences in children and lead to long-term neurological deficits. Having a high clinical suspicion and early recognition remain crucial for prompt treatment and improved outcomes in this population. Dr. Negar Asdaghi:         Endovascular treatment, or EVT, is an effective method to achieve recanalization and to improve clinical outcomes in ischemic stroke patients with a target vessel occlusion. Both advanced age and having a large infarct volume at the time of presentation are negative predictors of beneficial outcomes post-EVT. Despite this, the neurological benefits of EVT seem to persist across the spectrum of age, and the same has been observed for a range of ischemic core volumes. But it's important to note that, in general, patients presenting with large ischemic core volumes were excluded from the original thrombectomy studies, and currently there's several ongoing trials to determine whether EVT is beneficial for the large core population. Now, the question that everyone is interested in answering is whether there is an actual ischemic core volume beyond which endovascular therapy is either futile or potentially even harmful, and if this magic futile core volume is the same for all patients, or does it differ depending on the age and other factors. In a previous podcast, in an interview with Dr. Osama Zaidat, we learned about that important interaction between the presenting ischemic core volume as measured by ASPECTS score and advanced age in an analysis of patients enrolled in the STRATIS registry. In that study, no one over the age of 75 achieved functional independence post-EVT if the presenting ASPECTS score was under 5 regardless of the angiographic outcomes. In that interview, we also discussed the limitations of STRATIS registry as a non-randomized, single-arm study, and the issues surrounding using ASPECTS score to define ischemic core. In today's podcast, we're going to revisit the important interaction between the presenting ischemic core volume and age while reviewing a pooled analysis of seven endovascular clinical trials in the paper titled "Significance of Baseline Ischemic Core Volume on Stroke Outcome After Endovascular Therapy in Patients Age 75 Years or Older." I'm delighted to be joined today by the first and senior authors of this paper, Drs. Koji Tanaka and Andrew Demchuk. Dr. Tanaka is an Assistant Professor of Neurology at Kyushu University in Japan. With his experience working at the leading center for conducting stroke clinical trials in Osaka, he has now joined the Calgary Stroke Program as a research fellow. And he's accompanied today by his fellowship director, Dr. Demchuk. Dr. Demchuk, of course, needs no introduction to our Stroke readership and our podcast audience. He's a Professor of Neurology at the University of Calgary Cumming School of Medicine. He's a stroke neurologist and a leader in the field of cerebrovascular research who has been involved in multiple clinical studies and randomized trials, including the seminal studies that led to the approval of EVT as the standard of care for treatment of stroke. And, of course, he's a very special guest of this podcast this morning as he was my very own fellowship director. Top of the morning to you both, Andrew and Koji. Welcome to the podcast. Dr. Andrew Demchuk:   Thanks, Negar. It's great to be here. Dr. Koji Tanaka:               Thank you very much for your invitation. That is a great honor to be here. Dr. Negar Asdaghi:         Thank you both. Andrew, let's start with you. Can you please provide us some background on the pooled analysis and the HERMES collaboration, please? Dr. Andrew Demchuk:   Yeah, HERMES is a really, it's been a really fun journey. Years back, when these trials all came out roughly at the same time, right? There was a real quick succession of trials, the MR CLEAN trial was obviously first, and ESCAPE and others quickly followed it. It became very clear to us that it just made total sense to collaborate. And so we got together as a group and decided we will pool the data. We'll do it in a very careful scientific way with basically an independent statistical analysis, and develop a core imaging lab, and really actually share the workload amongst us. I remember one of the really interesting tidbits about HERMES is when we got together, in order, I think, to really build trust in the group, one of the important things we decided early was we were going to have a snake draft. If you don't know what a snake draft is, Negar, it's essentially where you take turns selecting a topic through each of the trials. So, every trialist got an opportunity to pick a topic, and we just went down the list until everyone had their turn, and then we'd start over again and do it again. And I think that really worked very well to be as democratic as possible with this, and as fair. And it really allowed for a lot to get done because whoever was motivated in the collaboration was able to do an analysis. Dr. Negar Asdaghi:         So, what a great summary of this collaboration. So, it's true collaboration between the trialists that basically gave us those seven original randomized trials. Andrew, can I just stay with you, and can you tell us a little bit about the patient population that were enrolled in those trials? Dr. Andrew Demchuk:   Yeah, I think one of the important things to know, and I think a limitation for any kind of analysis like this, is the trials generally were small core trials, right? I mean there are some, MR CLEAN was certainly a more generalized population, but many other trials, including ESCAPE, I mean the "S" and the "C" in ESCAPE is "small core," right? And so a lot of these trials were small core. So, we don't have a lot of data in larger core patients. But, as you can imagine when you do core lab analysis, you realize that some of the stroke patients weren't as small core as we thought they were when we enrolled them. So, there is some sufficient data to hypothesize. I would consider this paper very much hypothesis-generating. So, yeah, it is a limitation to be considered here. I mean, our sample size isn't very large in the big core patients. Dr. Negar Asdaghi:         Perfect. Thank you, Andrew. So, again, a recap for our listeners, that we are looking at pooled analysis of seven original trials of thrombectomy, but keeping in mind that those patients that were enrolled in the trials had, generally speaking, small presenting ischemic core. So, now, Koji, on to you. Can you walk us please through the current study, and what was the premise of it, and who was actually included in this study? Dr. Koji Tanaka:               Yes. In this study, we aimed to evaluate association between baseline ischemic core volume and the benefit of endovascular therapy over the best medical treatment on functional outcomes. Patients were categorized age over 75 years, and less than 75 years old. The primary outcome of interest was a modified Rankin Scale of three or less, and we included 899 patients who underwent this baseline ischemic core volume measurement, which corresponds to 51% of our patients in the HERMES collaboration dataset. Dr. Negar Asdaghi:         All right. So, just a quick recap of what you said. Thank you for this. So, we have 899 patients. Those patients were all included in the HERMES collaboration, but, of course, these are patients in whom we had presenting ischemic core measurements. And that will get me, actually, Koji, to my second question. Can you please walk us through how you did analysis of ischemic core volume measurements in this study? Dr. Koji Tanaka:               In this study, ischemic core volume was measured by CT perfusion in 591 patients and by diffusion-weighted imaging in 309 patients. We defined the ischemic core volume as a relative cerebral blood flow of less than 30% in CT perfusion and diffusion coefficient of less than 620 square micrometers per second in diffusion-weighted imaging. Previous studies showed ASPECTS moderately correlate with ischemic core volume in both CT perfusion and diffusion-weighted imaging. For example, ASPECTS of eight can be considered as ischemic core volume of 20 milliliters. But underlying [inaudible 00:28:21] were different between CT perfusion and diffusion-weighted imaging, and previous studies suggested CT perfusion occasionally overestimates the ischemic core volume was on diffusion-weighted imaging. In this study, the results did not change when analyzing CT perfusion and diffusion-weighted imaging separately. Dr. Andrew Demchuk:   Yeah, that's a really important point Koji makes, is that because we had sort of a, not quite a 50/50 split, we had a 60/40 split of CTP and DWI, we did analyze them separately, and the odds ratios of treatment effect were pretty similar at different core thresholds. So, they're fairly similar when you separate them out, but obviously the methodology is a little different between a CTP and a diffusion. And to Koji's point, he's absolutely right, the CTP has a tendency to slightly overestimate core when you compare to diffusion. Dr. Negar Asdaghi:         Yeah, and thank you. I think you already sort of alluded to what I was going to ask you and Koji, because, in reality, we have different ways of measuring core. We have the ASPECTS score, which is just a quick and dirty way of estimating or guesstimating core, and then we have CT perfusion, and we also have diffusion that sometimes is available to us, but not always. And the question is, in the heat of it, how we're going to measure the volume. With post-processing softwares, with CT perfusion, we get a quick potential ischemic core volume, but we don't have that capability with diffusion even if we did get diffusion. So, I think it's important to know that what Koji mentioned, an ASPECTS of eight can, more or less, in a quick fashion, be thought of as about 20 cc of core. And the other point that Koji raised was that CTP, again, this is sort of ballpark, can tend to overestimate ischemic core if you were to compare that with diffusion-weighted data. So, with that, now we have a study in which we have core volumes, and we're going to look at outcomes from endovascular thrombectomies compared to best medical management and see whether there is a correlation or interaction between ischemic core presentation, especially age. So, my next question would be to Andrew, can you walk us please through the main findings of the paper? Dr. Andrew Demchuk:   The whole goal of this paper was really to understand, are there thresholds in the older patients? When we looked at overall, and Bruce Campbell and the team wrote an important paper with HERMES and the CTP cohort overall, and the sort of message there was if you looked at shift analysis, there wasn't actually a core threshold found at all in HERMES for lack of benefit. There was a benefit across all the core volumes, but, of course, that's all ages. So, we were really interested in looking at the older patients because we felt there's more likelihood the core volume will matter in the elderly than in the younger patient. We know the younger population, it benefits overwhelmingly with EVT, it's hard to even find a core volume threshold. So, that was a premise. Essentially, we had 247 patients over 75 in the overall cohort, of which 98 had EVT. So, it was a decent population, and not a huge sample, but a decent sample. And so we looked at various things. The first thing that was interesting we found was that infarct volumes, the average infarct volume to achieve an mRS three or less, was lower in the older patients, significantly lower, was 23.9 for younger patients under 75 and 10.7 for the older patients. You tend to have much smaller infarcts to achieve good outcome. And so that was kind of interesting, and I think that's been shown by others. Then we got into the weeds to try to figure out, OK, what are these thresholds? And if there's one figure that matters, Negar, you know me to always point out that there's always one figure or table in a paper that's kind of where the money is, where the real learning is, and that's Figure 2 on this paper in my opinion, beautiful figure with four figure A, B, C, and D. And it really sort of nicely highlights these issues and these cutoffs. But what we saw is that in the older patients who received EVT, around 50 mils seemed to be a threshold to achieve zero three, you had to, to see treatment effect, you had to have a baseline infarct volume less than 50 mils for a zero three outcome advantage. For zero four, it was 85 mils. And then we looked at this issue of what we called futility, true futility. And that's a very controversial thing. What is futility, or how do you measure futility? And really, I think, we even had a debate about this as a HERMES group when we were designing the analysis, and we sort of landed on mRS five six. A 90% chance of mRS five six, right? That's quite the bar, right, to say true futility because some people argue mRS four is still not a horrible outcome. Culturally, that is an OK outcome in some situations. But when we did use that five six 90% threshold, it was 132 mils. So, you're getting up to these really large volumes. But here's the catcher in the whole thing, and Koji will probably speak to this a bit more. I don't want to steal his thunder too much, but this issue of reperfusion seemed to matter in this. And we'll come back to that maybe with another question. Reperfusion matters a lot when you think about these thresholds. Dr. Negar Asdaghi:         OK, so, Andrew, a lot of information, I don't know if I need a recap myself to recap, but basically what you mentioned is that for the older patients who received EVT, if we keep our eyes on the outcome of mRS of zero to three, it seems to be the magic core volume for that outcome post-endovascular therapy that it lands on the magic volume of 50 cc core. Did I get that right? Dr. Andrew Demchuk:   That's correct. Dr. Negar Asdaghi:         Then if you're still a bit more lenient with the definitions of what is favorable outcome, what outcomes we're looking at and so on, so forth, for an mRS of five to six, then when we talk about futility of endovascular thrombectomy, the volume that you mentioned, and again I want to ask you this, this volume is for elderly over the age of 75, is 130 mil. Dr. Andrew Demchuk:   132, but yeah, absolutely. But there's a real catcher here, and we need to really emphasize the catcher in this. Dr. Negar Asdaghi:         Okay. I will ask you one more question before I go to Koji, which I'm sure is going to tell us more about that catcher. Andrew, can you please tell us about the factor of time? I feel like that is something that we need to discuss, as well. Your study included patients early on in their stroke onset, but we're talking about an important interaction. The question is, do you think the results of this interaction would be different or impacted by the value of time? Dr. Andrew Demchuk:   Hypothetically? It must, right? I think that that must be the case. We don't have any data specific to this. That would be an interesting Aurora analysis to do. Now, of course, the challenge with late window analysis is, we are really small core in our late window trials, we probably have even a much smaller proportion of large cores. So, to be able to even tackle that question in the late window is, I don't know if we have the data yet, to be honest. But it makes sense that you would expect the thresholds to be a bit lower the later you are in the window. But that is a hypothetical opinion. Dr. Negar Asdaghi:         Right, so, I want to take that and come to Koji. I want to digress a little bit to Koji and see how we can understand the finding of this current analysis of this paper. So, small core patients early on into their onset, we're looking at the interaction between age and their core volume and coming up with numbers 50 cc for the elderly population. If you're looking at the outcome of zero to three or 132, as Andrew pointed out, for an MRS of much higher, four or five. Dr. Andrew Demchuk:   Actually five, six, 90% chance of five, six. So, it's there. It's like almost everybody got five, six, took 132 mils to get there. So, it's like this extreme outcome. Dr. Negar Asdaghi:         Right, so, exactly, and I have to correct it, again, mRS of five or six or dead or almost dead mRS basically. Dr. Andrew Demchuk:   In 90% of patients. Dr. Negar Asdaghi:         90% of patients. So, we have these important numbers here, and I want us to basically understand these numbers in these volumes in the context of the recently published RESCUE-Japan LIMIT study. Can you tell us a little bit about that study and how we can make sense of these volumes in the setting of that paper? Dr. Koji Tanaka:               In the recent RESCUE-Japan LIMIT trial, the median ASPECTS was lower, and baseline ischemic core volume was greater than those in our study. And surprisingly, the median ischemic core volume in that trial was close to our threshold to predict less than 10% of patients achieve a modified Rankin Scale of four or less after endovascular therapy. We thought this is due to much higher complete reperfusion rate in HERMES patient. We have much interest in their additional analysis for outcomes in elderly patients by reperfusion status. This potential benefit of endovascular therapy in the area is promising for the future clinical trials. Dr. Andrew Demchuk:   I think just to add to that, it was actually really interesting, Negar, because when we were analyzing all of this and then the trial came up and it was actually really nice because we're like, OK, how does our data relate to their data? And that's where Table 2 comes in, and it would almost be worth putting on the pod, whatever, I don't know if you have on your podcast website, you have one figure that you can sit there with as you listen to the podcast, because that would be the figure. Dr. Negar Asdaghi:         We'll work on that Andrew, but tell us a little bit more because, really, when I read the trial results, the way I understand it is that people enrolled in RESCUE-Japan that were older than 75, and these are all large core patients, benefited more from endovascular therapy than their younger counterpart. How do I understand that? I don't know how to wrap my head around that finding. Dr. Andrew Demchuk:   You want to try to answer that, and then I'll add? Dr. Koji Tanaka:               As I mentioned previously, we want to know about the exact patient population just only for elderly patients, whether they have a exactly larger ischemic core volume or as well as their functional outcome. How many patients achieved modified Rankin Scale four or less or three or less, or more than five or six? Dr. Andrew Demchuk:   Koji's point's very important. We actually don't have the breakdown of the mRS, so we don't know if they created a lot of fours, or threes, or what. So, that's one issue. But I think that the key to this whole thing is to understand that this is a 2022 trial. HERMES data is essentially a 2015 equivalent where we're looking at a number of clinical trials who roughly ended between 2014, 2016. So, the technology, the technique, the operators, are just at a different level back then than now. And quite frankly, EVT is an improving treatment. We probably don't even fully understand how much, I mean, we're just getting better at it. And I think what's happened here is the reperfusion rates have improved. And our HERMES reperfusion rates, remind me, Koji, I think they're about half, we think, in HERMES, than like the TICI 2bs, threes, are half in HERMES what they got in RESCUE-Japan LIMIT. So, when you achieve successful reperfusion, what were the numbers here? TICI 3 was 43% in the Japan RESCUE LIMIT, and 8.6% in HERMES. Okay, TICI 3s were not ... Now that may be slight differences in core lab interpretation, but we were just starting to get good at 3s. We were getting a lot of 2bs and some 2cs, but we weren't getting a massive number of 3s back in 2015. Well, voilà, now we are, right? We're hitting home runs when we didn't before. And I think that has really shifted the goalposts on the large core. If you open the vessel, they can still do well if they're elderly, but you've got to really open that vessel. And in HERMES, we only did that in a small portion of patients. So, these thresholds are sort of representative of 2015 skill. Dr. Negar Asdaghi:         Golden points, Andrew and Koji, both of you. I want to recap what you mentioned here. A note to all of our audience and listeners that we are looking at an analysis with RESCUE-Japan, an analysis of a 2022 study. And the patient population that were enrolled were also treated much later in terms of time than the patient population that was enrolled in the HERMES collaboration and in all of the trials that contributed to HERMES. So, we've got to remember that EVT is this fluid, ongoing, everyday-improving therapy, from our techniques to everything else, you know, how fast we get patients to the angiosuite. And the point that you raise, I want to repeat that, the percentage or the odds of achieving a perfect reperfusion was, in RESCUE-Japan, was 43% odds of TICI 3 reperfusion, whereas only 8.6%. So, when we're talking about all of these predictive modeling or predictive factors that will tell us who's going to do well, who's not going to do well, it also is predicated on the angiographic success. And perhaps in the earlier trials or even the early study that we covered as part of the STRATIS registry, we put everybody, TICI 3s with TICI 2b or better, whereas nowadays we accept the best, TICI 3s, and maybe that improved percentage in the most recent trial, the RESCUE-Japan, really did what it had to be done for the elderly population to keep that in mind. And Andrew, before we end our interview, I want us to get your top two takeaway messages from this paper. Dr. Andrew Demchuk:   Clearly, elderly patients do better when their strokes are smaller, that we know, compared to younger patients. But it's all about hitting the home run. It's all about hitting the home run. Figure 2C and 2D, you can see that if you achieve that high TICI score, a significant proportion of elderly patients potentially could still benefit, 30–40% reasonable outcomes with bigger cores if you get those high TICI scores. So, it is about hitting the home run in reperfusion in the elderly. You need to go for it, and hopefully you're successful, because if reperfusion isn't successful, then generally the outcomes are not ideal and they certainly worsen as the core volumes become larger, bigger. Dr. Negar Asdaghi:         Before I ended the interview, given Andrew's tremendous experience as a longtime fellowship director and seeing that he was flanked by two of his fellows, one past, myself, and one present, Koji, I had to ask him one final question of what his philosophy is as an educator. Dr. Andrew Demchuk:   I have a sort of philosophy on life with fellows. I always look for the special power in a fellow. I realized a long time ago we're all, we're not perfect, nobody's perfect, I'm not perfect, but there's usually a special power in people, and if you spend the time to get to know them, you identify that special power, and you really help harness it because you know that if they can harness it when they go back to their faculty job, they're going to really contribute something special to their team, right? You can imagine six special powers from six different people in a team. Now you've got a real team, right? If you know what your power is, you know your limitations, but you know where your strengths you can add to the group, and that's what we try to do here when we can. It's not always, you know, special powers, you have to kind of seek them out. But they're there in most people, and that's really important for career down the line. Dr. Negar Asdaghi:         And this concludes our podcast for the December 2022 issue of Stroke. Please be sure to check out this month's table of contents for the full list of publications, including our very interesting Stroke Images series. In this month, we have a case of progressive cervical myelopathy secondary to a dural AV fistula supplied by the anterior inferior cerebellar artery. We also have a separate case of carotid rete mirabile imaged with a four-dimensional flow MRI study. And with these cases, we bring our 2022 Stroke Alert Podcast series to an end. Over the past 12 months, we've ended our podcasts with various inspirational tales. From the moving account of the American runner Steve Prefontaine and the remarkable journey of the Syrian refugee and Olympian swimmer Yusra Mardini, to the discovery of positron and Commander Armstrong's landing on the moon, our podcast stories have but one thing in common, which is the story of human perseverance and consistency in the face of hardship. So, as we end 2022 to start 2023 anew, Andrew's comments on finding that special power in each of us resonate with our resolution to stay alert with Stroke Alert. This program is copyright of the American Heart Association, 2022. The opinions expressed by speakers in this podcast are their own and not necessarily those of the editors or of the American Heart Association. For more, visit AHAjournals.org.

It's 5:05 on Thursday, November 10th, 2022. This is your daily update of open source and cybersecurity news that might have slipped by the major news sources. We have 20 reporters from around the world. Today's updates are from Edwin Kwan in Sydney, Australia. Mark Miller in New York City, DJ Schleen in Golden, Colorado and Olimpiu Pop from Transylvania, Romania. Let's get to it.Stories covered in this episodeDJ Schleen, Golden, ColoradoPeloton, Spotify, Intel, Oracle, Equifax, Microsoft, loom, Zillow, Synk, Open Door, Twitter, Zendesk, Salesforce, and Meta. What do these companies have in common? Laying off tens of thousands of employees in the last 30 days, and they're not the only ones. Olimpiu Pop, Transylvania, RomaniaSigstore announced the general availability of its ecosystem agnostic, no cost signing service during the inaugural SigStoreCon in late October. Sigstore, a newly accepted Linux Foundation project, is a critical and much needed step towards accessible software signing, which has become a key component of software supply chain management, and security.Mark Miller, New York CityOne of the people I check in with on a regular basis is Allan Friedman. Allan is leading CISA's efforts to coordinate SBOM efforts inside and outside the United States government. When he points out an article, you can be sure there's value in it. This morning he highlighted an article by Eric Goldstein, Executive Assistant Director for the Cybersecurity and Infrastructure Security Agency.Edwin Kwan, Sydney, AustraliaExperts are urging for cybersecurity to be taught to kids as young as five years old. There's been a huge increase in the number of data breaches being reported in Australia in the last few weeks. While the Australian government is making improvements to national cybersecurity and increasing financial penalties for companies, cybersecurity experts are urging that more needs to be done to raise the nation's security awareness.

Besides choosing their favorite candidates on election day, voters in New York will also turn over their ballot and find a handful of questions. WCBS'S Steve Burns is taking a look at question one. He spoke with Eric Goldstein at the Natural Resources Defense Council.

The Department of Justice's collaboration with foreign law enforcement organizations has resulted in the disruption of a Russian malware operation. At CyberTalks, DOJ's Deputy Attorney General for National Security and Cyber Adam Hickey discusses how the partnership was able to disrupt this botnet. National Cybersecurity Awareness Month is about two-thirds over now. Eric Goldstein, executive assistant director for cybersecurity at the Cybersecurity and Infrastructure Security Agency, explains at CyberTalks what his agency is emphasizing this month. The Department of Veterans Affairs is missing data it needs to gauge the health of its acquisition workforce. That data would help the agency understand who does what, and how. Shelby Oakley, director of contracting and national security acquisitions at the Government Accountability Office, explains what we now know about VA's acquisition workforce. The Daily Scoop Podcast is available every weekday afternoon. If you want to hear more of the latest from Washington, subscribe to The Daily Scoop Podcast on Apple Podcasts, Google Podcasts, Spotify and Stitcher. And if you like what you hear, please let us know in the comments.

On this almost-Summer Friday, enjoy some of our favorite recent conversations: Building on her New Yorker essay, Elizabeth Alexander, president of The Mellon Foundation, poet, educator, memoirist and scholar, examines the challenges of young Black Americans in her new book, The Trayvon Generation (Grand Central Publishing, 2022). First, listeners discuss ways they've changed their diet to help combat climate change.  Then, Eric Goldstein, New York City environment director at the Natural Resources Defense Council (NRDC), explains how the various ways of composting help in the fight against climate change. Suzanne Nossel, PEN America chief executive officer, and Elie Mystal, justice correspondent for The Nation and the author of Allow Me to Retort: A Black Guy's Guide to the Constitution (The New Press, 2022), debate the state of free speech in America. Piping Plovers are tiny endangered shorebirds who spend part of the spring and summer right here in the Rockaways. Chris Allieri, founder of the NYC Plover Project, talks about how volunteers are working to protect the birds as they begin nesting on the beach. These interviews were lightly edited for time and clarity; the original web versions are available here: Young and Black in America (Apr 6, 2022) Climate Change and What You Eat (Feb 22, 2022) Climate Change and Composting (Mar 3, 2022) Debating Cancel Culture (Mar 30, 2022) Protecting Piping Plovers (Apr 5, 2022)

By most accounts, federal agencies have made great strides since last May's cyber executive order. Still, at the one mark, lawmakers pressed Biden administration officials on whether agencies have done enough to defend critical networks from cyber attacks. For more, Federal News Network's Justin Doubleday

Eric Goldstein, New York City environment director at the Natural Resources Defense Council (NRDC), explains how the various ways of composting help in the fight against climate change.

After last week's deadly flooding, President Biden toured parts of Queens, meeting with homeowners who are still recovering from the storm. Biden, along with Governor Hochul and Mayor de Blasio, reiterated the urgent need to act on climate change and prepare for the next extreme weather event, especially in vulnerable communities. Eric Goldstein, the New York City environmental director for the Natural Resources Defense Council, joined Errol to talk about what the city should be doing to make the five boroughs more resilient, including upgrading the aging infrastructure like its sewer system. He also talked about efforts to reduce building emissions and the importance of divesting from fossil fuels. And he analyzed Hochul's new law requiring most vehicles sold in the state to be zero emissions by 2035. If you enjoyed this episode, check out Errol's previous conversation with Bill McKibben.   JOIN THE CONVERSATION Weigh in on Twitter using the hashtag #NY1YouDecide or give us a call at 212-379-3440 and leave a message. Or send an email to YourStoryNY1@charter.com

Today on The Grail my guest Eric Goldstein former owner of the incredible Denim shop in NYC called JEAN SHOP. I met Eric back in 2005 at his shop and fell in love with his Denim and Leather goods immediately. Eric built his Denim company from the ground up but after 14 years of hard work he has closed the doors and now he is the Business Leader of Denim and Jeans, at Vidalia Mills.  This episode has tons of Great Denim history so do not miss it. Don't forget to leave a review on iTunes and Youtube. Have a great weekend. DDR

Eric Goldstein, Executive Director of Cyber Security at CISA, and former National Security Council lawyer, John Dermody talk about the threats, challenges and solutions.

Whiteness in America isn't just the neutral norm against which racial minorities, particularly Black people, are measured. Whiteness in America means having the privilege and power that go along with being part of that supposed norm. And becoming white – not in terms of pigment but of social status – is a choice that nearly every immigrant or refugee group in America has had to embrace or reject. We talk with two scholars in the field of Whiteness Studies, Nell Irvin Painter and Eric Goldstein, about how understanding the construction of white identity in this polyglot country gives us keen insights into its troubled racial history. MUSIC CREDITS Turning to You by Blue Dot Sessions Our Only Lark by Blue Dot Sessions Heather by Blue Dot Sessions A Certain Lightness by Blue Dot Sessions The Crisper by Blue Dot Sessions Throughput by Blue Dot Sessions Pukae by Blue Dot Sessions Four and Fourteen by Blue Dot Sessions The Longshoreman by Blue Dot Sessions Ewa Valley by Blue Dot Sessions Careless Morning by Blue Dot Sessions Morning Glare by Blue Dot Sessions Lick Stick by Blue Dot Sessions

In this week's episode, April and Tracie discuss Eric Ward's Skin in the Game point about the conditional whiteness of Ashkenazi Jews, unpacking (with both/and thinking) the reaction some Jews have regarding their whiteness. April uses her experiences as a United States citizen living in Senegal to explain how conditional privilege operates. Check out our discussion/reflection questions for this episode: www.joyousjustice.com/blog/jews-talk-racial-justice-ep-45Find April and Tracie's full bios and submit topic suggestions for the show at www.JewsTalkRacialJustice.comLearn more about Joyous Justice where April is the founding and fabulous (!) director, and Tracie is a senior partner.: https://joyousjustice.com/Read more of Tracie's thoughts at her blog, bmoreincremental.comRead Eric Ward's Skin in the Game: How Antisemitism Animates White Nationalism  here: https://www.politicalresearch.org/2017/06/29/skin-in-the-game-how-antisemitism-animates-white-nationalismEric Ward's appearance with the Jewish Museum of Maryland: https://jewishmuseummd.org/events/the-root-of-white-supremacy/Check more about Robin DiAngelo's work here: https://www.robindiangelo.com/For more about Jews and Whiteness, read _The Price of Whiteness_ by Eric Goldstein: https://press.princeton.edu/books/paperback/9780691136318/the-price-of-whitenessListen to our episode on the importance of affinity spaces here: https://joyousjustice.com/blog/jews-talk-racial-justice-ep-43Read about the philosophy of The Good Place (careful, spoilers for the entire show): https://www.vox.com/future-perfect/2019/9/26/20874217/the-good-place-series-finale-season-4-moral-philosophy#:~:text=The%20Good%20Place%20has%20laid,do%20good%20front%20and%20center.

One of the topics I get asked to cover frequently is the growth of the corporate executive recruiting function. So with that in mind, I've partnered with ESIX, The Executive Search Information Exchange, to bring you a series of three interviews exploring the key trends and issues in corporate executive recruiting. In the previous two episodes, we looked at the evolution of corporate executive recruiting and what employers should be doing to improve the diversity of their executive teams. For the final interview in this short series, I'm talking to Eric Goldstein, Global Head of Executive Talent Attraction at SAP. We discuss how long term talent engagement is starting to play a more significant role in executive recruiting, the growth of data-driven decision making and what the future might look like.    ▪   Topics covered in the interview:    ▪   Hyper competitive talent markets    ▪   Proactive executive talent engagement    ▪   Engaging at scale and offboarding conversations quickly.    ▪   Involving hiring managers effectively    ▪   Unbiasing assessment    ▪   Measuring quality of hire    ▪   Onboarding, integration and accountability    ▪   Lessons learned around improving diversity.    ▪   What is the future of corporate executive recruiting Listen to this podcast in Apple Podcasts.

One of the topics I get asked to cover frequently is the growth of the corporate executive recruiting function. So with that in mind, I've partnered with ESIX, The Executive Search Information Exchange, to bring you a series of three interviews exploring the key trends and issues in corporate executive recruiting. In the previous two episodes, we looked at the evolution of corporate executive recruiting and what employers should be doing to improve the diversity of their executive teams. For the final interview in this short series, I'm talking to Eric Goldstein, Global Head of Executive Talent Attraction at SAP. We discuss how long term talent engagement is starting to play a more significant role in executive recruiting, the growth of data-driven decision making and what the future might look like.    ▪   Topics covered in the interview:    ▪   Hyper competitive talent markets    ▪   Proactive executive talent engagement    ▪   Engaging at scale and offboarding conversations quickly.    ▪   Involving hiring managers effectively    ▪   Unbiasing assessment    ▪   Measuring quality of hire    ▪   Onboarding, integration and accountability    ▪   Lessons learned around improving diversity.    ▪   What is the future of corporate executive recruiting Listen to this podcast in Apple Podcasts.

One of the topics I get asked to cover frequently is the growth of the corporate executive recruiting function. So with that in mind, I've partnered with ESIX, The Executive Search Information Exchange, to bring you a series of three interviews exploring the key trends and issues in corporate executive recruiting. In the previous two episodes, we looked at the evolution of corporate executive recruiting and what employers should be doing to improve the diversity of their executive teams. For the final interview in this short series, I'm talking to Eric Goldstein, Global Head of Executive Talent Attraction at SAP. We discuss how long term talent engagement is starting to play a more significant role in executive recruiting, the growth of data-driven decision making and what the future might look like.    ▪   Topics covered in the interview:    ▪   Hyper competitive talent markets    ▪   Proactive executive talent engagement    ▪   Engaging at scale and offboarding conversations quickly.    ▪   Involving hiring managers effectively    ▪   Unbiasing assessment    ▪   Measuring quality of hire    ▪   Onboarding, integration and accountability    ▪   Lessons learned around improving diversity.    ▪   What is the future of corporate executive recruiting Listen to this podcast in Apple Podcasts.

In the aftermath of 11 days of violence between Israel and Gaza, the term “apartheid” has circulated in the media and among activists to describe the Israeli government's control over Palestinians and the Palestinian territories. But the debate about whether or not Israel's policies amount to apartheid is nothing new.Related: Prospects of a ceasefire offer hope to ending violence between Israel and HamasIn April, Human Rights Watch, the global advocacy group, issued a report accusing Israel of “persecution and apartheid,” including the dispossession, confinement, forcible separations, and subjugation of Palestinian people to “varying degrees of intensity” in certain areas. Groups that use the term do so strategically to emphasize the need for a paradigm shift in the region. But others argue that the word is loaded and that it doesn't apply to the situation between Israel and Palestinians. Related: Why a leading Israeli rights group calls Israel an 'apartheid' stateEric Goldstein, who edited the Human Rights Watch report, said he doesn't take the term lightly. “I think that 20 years ago, we would not have called the situation apartheid,” Goldstein said. Back then, the Oslo peace process was in full swing and many people anticipated the establishment of two states, one for Palestinians and one for Israelis, Goldstein said. “And so, whatever abuses that were occurring in the occupied territories, however bad they might have been, it looked like a temporary situation.” But after 54 years of military occupation — Goldstein said the situation feels very far from temporary.The problem is most glaring in the West Bank, he said, where everyone lives under the same Israeli authority, but Jewish Israelis have full political and legal rights, while Palestinians do not. Related: Israel vaccinates Palestinian day laborers as their families wait Goldstein said this system is a version of apartheid.According to the International Criminal Court, apartheid is a state's system of legalized, racial discrimination in which one racial group is deprived of political and civil rights. Under international law, apartheid is defined as a crime against humanity. “We're not using apartheid like flamethrowers, we're not using it as an insult word. It's a term meant to refer to a particularly severe type of systemized kind of discrimination."Eric Goldstein, editor, Human Rights Watch“We're not using apartheid like flamethrowers, we're not using it as an insult word. It's a term meant to refer to a particularly severe type of systemized kind of discrimination,” he explained. Lessons from South Africa The word apartheid originated in South Africa to describe the racist political system that governed every aspect of life from 1948 to 1991. Over the past 20 years, the term has become much broader. But the word is still so loaded that many experts won't go near it. Nor should they, said veteran journalist Hirsch Goodman, who has covered Israeli politics.  “Apartheid is a sacred word. It is not to be used lightly." Hirsch Goodman, veteran journalist“Apartheid is a sacred word. It is not to be used lightly,” said Goodman, who grew up in South Africa and immigrated to Israel in 1965, as a teenager.  He said the people who use the term apartheid to describe Israel are usually activists who want to present an ugly caricature of the Jewish state and undermine its right to exist. “The word apartheid, having grown up with it — no free press, no free thought, arrest without trial, like Stasi police, 2 million whites subjugating 20 million Black [people], moving populations from rich farmland to bantustans — a system that is so horrible … I can't even begin to see the comparison,” Goodman said. But many South Africans do see the comparison — including the president, Cyril Ramaphosa, who was an anti-apartheid activist. In an interview with France 24 last month, Ramaphosa said the plight of Palestinians triggered a horrible sense of déjà vu.“The images that we've been seeing of people being prevented to move around, of their homes being destroyed, brings back very terrible memories of our own history under apartheid,” he said. Related: Biden is 'no savior' for Palestinians, should hold Israel 'to account'A younger generation of South Africans also sees parallels. Muhammed Desai, an activist with a group called Africa 4 Palestine, was 5 years old when apartheid ended in 1991. In 2004, he took a gap year in Israel. He said that some of his experiences there were “a stark reminder of South Africa's apartheid regime and of Israel's own complicity with apartheid South Africa.”  Israel became a friend of the South African apartheid regime in the 1970s. It was one of the last Western nations to sever ties with the country after global sanctions were imposed in the late '80s.     On the other hand, anti-apartheid freedom fighter Nelson Mandela was friends with Yasser Arafat, then-chairman of the Palestine Liberation Organization. The PLO provided military support to the African National Congress in the 1970s.That's why many Black South Africans identify with Palestinians and are active in the anti-Israel “boycott, divestment and sanctions” movement, Desai said.  The movement has organized Israel Apartheid week on college campuses since 2005.Related: Climate divestment activists draw inspiration from South Africa's anti-apartheid movement“Long before it was fashionable, long before it was attractive or sexy, it was the Palestinans who gave us financial resources, who gave us military training, they gave us other various forms of solidarity, so in some ways, it's paying back for that."Muhammed Desai, activist, Africa 4 Palestine“Long before it was fashionable, long before it was attractive or sexy, it was the Palestinians who gave us financial resources, who gave us military training, they gave us other various forms of solidarity, so in some ways, it's paying back for that,” Desai said. Rhetoric, consequencesThe debate over the term apartheid isn't just about rhetoric — it's about consequences. “Whether you call the situation apartheid, occupation or conflict will determine the particular roles and responsibilities of those involved,” said Leonie Fleischmann, who teaches international politics at City, University of London.The '90s Oslo peace process relied on the term "conflict."“When it's defined as the Israeli-Palestinian conflict, it's a case of two equal sides who need to come together on a negotiation table to resolve the conflict,” Fleischmann said. Now, Fleischmann said, the international community calls Israel's controls over Gaza, the West Bank and east Jerusalem a military occupation.Fleischmann said under this framework, the occupier — Israel — has certain obligations toward the occupied people, the Palestinians. But at the same time, Israel can legally take its security into account.Israel can argue that its recent military campaign against Gaza was necessary “in order to protect the security of Israelis,” Fleischmann said. “...[A]s soon as you start talking about the situation in terms of apartheid, that idea of balancing interests is no longer applicable.”Leonie Fleischmann, educator, City University of London“But as soon as you start talking about the situation in terms of apartheid, that idea of balancing interests is no longer applicable.” Goldstein, with Human Rights Watch, said he wants the international community to talk less about one state or two — and more about how to secure equal rights for everyone, from the Jordan River to the Mediterranean Sea — the full area encompassing Israel and the Palestinian territories. “Let's start with giving everybody their rights and then work for a resolution to the outstanding political issues,” Goldstein said. He hopes that's a vision most people can get behind, whether they use the word apartheid or not.

Dr. Eric Goldstein discusses Eagle Syndrome.

This week's podcast is the next of a new series entitled, “The Market for Cotton,” where we introduce leading economists, researchers and analysts from across the agriculture, textile, apparel and retail industries, to you, our listeners. So, please join us for an engaging and wide-ranging discussion about the textile and apparel industry, how farmers can interact with brands, and the importance of sustainable production and traceability with Eric Goldstein, Director of Denim Sales and Business Development at Vidalia Mills. In this week's podcast, Mr. Goldstein talks about denim, reshoring, and the importance of bringing farmers and apparel brands together to meet the needs of today's consumers, who more than ever want to know how and where their clothes are made. This is an important conversation and a must-listen for anyone interested in the apparel business and its cotton supply chain. Hosted by Jennifer Crumpler, Fiber Development Manager and Manager of the e3 Sustainable Cotton Program from BASF, and interviewed by industry consultant Bob Antoshak.

We are very excited for this week’s show, in which we interview Eric Goldstein–the Executive Assistant Director for Cybersecurity at DHS CISA!  We had a terrific conversation, with a focus on (1) understanding the specific...

Are Israel's policies over the West Bank and Gaza Strip war crimes? What are the implications of such an accusation? Do these policies come from Israel's security concerns, or are they pretextual explanations for their repressive treatment over the Palestinian population? Eric Goldstein, acting Executive Director of the Middle East and North Africa Division of Human Rights Watch, talks to RBI Director John Torpey about the latest HRW report that accuses Israel of crimes against humanity. He discusses what that means and how the determination was made, HRW's efforts to stay impartial in their inherently political work, and what governments response to the report indicate for the future of Israel. You can read the transcript at https://ralphbuncheinstitute.org/2021/05/10/the-human-rights-watch-report-charging-israel-with-the-crime-of-apartheid-with-eric-goldstein/

This episode is a recording of an APN webinar with Omar Shakir and Eric Goldstein of Human Rights Watch, discussing HRW's new report on Israeli violations of Palestinian human rights. Omar Shakir is the Israel and Palestine Director of Human Rights Watch, and the chief author of the report. He is a graduate of Stanford and Georgetown. Prior to his work documenting human rights violations by Israel, the Palestinian Authority in the West Bank and Hamas in Gaza, he worked on documenting human rights violations by the Egyptian government and by the US government in Guantanamo Bay. Eric Goldstein is the Director of Human Rights Watch's Middle East and North Africa division. He has been working on human rights in the Middle East since the 1980s. Eric’s chief expertise in recent years has been human rights violations in the Magreb. He is a graduate of Harvard and Columbia University, and has taught human rights in Princeton and Georgetown. A link to the report: https://www.hrw.org/report/2021/04/27/threshold-crossed/israeli-authorities-and-crimes-apartheid-and-persecution Contact Ori: onir@peacenow.org Donate to APN: https://peacenow.org/donate  

Podcast: To The Point - Cybersecurity (LS 34 · TOP 5% what is this?)Episode: A Focus on Resiliency with CISA’s Eric GoldsteinPub date: 2021-04-27This week we discuss the importance of a focus on assuring resiliency of critical functions as the cybersecurity path ahead with Eric Goldstein, Executive Assistant Director for Cybersecurity for the Department of Homeland Security’s Cybersecurity and Infrastructure Security Agency (CISA). Eric also shares insights on executing CISA’s mission in today’s dynamic and exciting cybersecurity landscape, the criticality in prioritization and a risk-based approach in addressing security for critical infrastructure, the role of visibility and continuous assessment in addressing today’s cyber landscape as well as pathways to standardizing cyber breach disclosure across government agencies and businesses of all sizes. Visit CISA.gov to learn more about CISA’s mission and programs as well as the many professional opportunities to join one of today’s most essential frontline cyber defense agencies. For links and resources discussed in this episode, please visit our show notes at https://www.forcepoint.com/govpodcast/e130The podcast and artwork embedded on this page are from Forcepoint | Global Cybersecurity Leader | Protecting the Human Point, which is the property of its owner and not affiliated with or endorsed by Listen Notes, Inc.

This week we discuss the importance of a focus on assuring resiliency of critical functions as the cybersecurity path ahead with Eric Goldstein, Executive Assistant Director for Cybersecurity for the Department of Homeland Security’s Cybersecurity and Infrastructure Security Agency (CISA). Eric also shares insights on executing CISA’s mission in today’s dynamic and exciting cybersecurity landscape, the criticality in prioritization and a risk-based approach in addressing security for critical infrastructure, the role of visibility and continuous assessment in addressing today’s cyber landscape as well as pathways to standardizing cyber breach disclosure across government agencies and businesses of all sizes. Visit CISA.gov to learn more about CISA’s mission and programs as well as the many professional opportunities to join one of today’s most essential frontline cyber defense agencies. For links and resources discussed in this episode, please visit our show notes at https://www.forcepoint.com/govpodcast/e130

Dr. Eric Goldstein discusses Fabry Disease.

Dr. Eric Goldstein discusses cerebral amyloid angiopathy-related inflammation, also known as CAARI.

Dr. Eric Goldstein discusses primary central nervous system vasculitis, also known as PCNSV.

Dr. Eric Goldstein discusses cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, also known as CADASIL.

Ted Rall, political cartoonist and syndicated columnist, joins us to talk about reports of a massive hacking operation involving US government websites. Nearly all mainstream Western media outlets are repeating the claims that the Russian government is involved in the hack, but the US government has not provided evidence. Sen. Dick Durbin (D-IL) in a Thursday speech before the Senate called the hacking operation a "virtual invasion by the Russians into critical accounts of the federal government," and Biden has promised to impose "substantial costs" on those responsible, according to Fox News.Dr. Linwood Tauheed, associate professor of economics at the University of Missouri-Kansas City, returns to The Critical Hour to discuss the state of the US economy as jobless claims remain elevated and Congress squabbles over a stimulus package. Recent negotiations point to a final deal that will not include money for state and local governments despite projections that over 5 million workers will face layoffs without such funds.Dr. Jehan "Gigi" El-Bayoumi, professor of medicine and founding director of the George Washington University School of Medicine and Health Sciences' Rodman Institute; and Dr. Yolandra Hancock, board-certified pediatrician and obesity medicine specialist, return to discuss reports that a panel of independent experts recommended overwhelmingly that the US Food and Drug Administration (FDA) grant Moderna's COVID-19 vaccine an emergency use authorization. Our panel discusses the efficacy and safety issues that have so many people apprehensive about taking the vaccine. Are their fears valid, and will these fears complicate the use of vaccine therapy to overcome the deadly pandemic?Daniel Lazare, investigative journalist and author of "The Velvet Coup"; and Ray McGovern, former CIA analyst and co-founder of Veteran Intelligence Professionals for Sanity, come together to discuss several of the most important stories of the week. Chief among these stories is one that involves recordings that recently surfaced from James O'Keefe's Project Veritas, revealing that WikiLeaks co-founder Julian Assange contacted the State Department in 2011 and notified it that 250,000 diplomatic cables had been stolen from WikiLeaks and may be released soon. Assange advised the department to take mitigating actions to protect personnel because the necessary redactions and precautions may not have been taken by the thief.Dr. Gerald Horne, professor of history at the University of Houston, author, historian and researcher; and Danny Haiphong, author and contributor to Black Agenda Report, team up to review another group of major stories from the week. They address growing concerns Biden is building a political team chock full of notorious Wall Street operatives. Reports show that Biden has grown his transition team with new additions, such as 18-year Goldman Sachs employee Eric Goldstein; Monica Maher, vice president for cyber threat intelligence at Goldman; and Josh Zoffer, who was formerly an engagement manager at McKinsey and now works at private equity firm Cove Hill Partners.

Ray McGovern, former CIA analyst and co-founder of Veteran Intelligence Professionals for Sanity, joins us to discuss a recent Washington Post article in which the authors claim that Russian intelligence personnel have been involved in an ingenious hack against US government websites and cybersecurity firms. The article paradoxically argues that the hacks were brilliant and almost undetectable but goes on to give every minute detail of the operation. Our crew also discusses the story's conspicuous financial aspect, as one of the principal companies that was named as a target made a fortune in stock transactions days before the story was released.Caleb Maupin, journalist and political analyst, joins us to talk about the growing concern that US President-elect Joe Biden is building a political team chock full of notorious Wall Street operatives. Reports show that Biden has grown his transition team by adding 18-year Goldman Sachs employee Eric Goldstein; Monica Maher, vice president for cyber threat intelligence at Goldman; and Josh Zoffer, who was formerly an engagement manager at McKinsey and now works at private equity firm Cove Hill Partners.Niko House, political activist, independent journalist and YouTube star, returns to The Critical Hour to discuss the raging civil war in the Democratic Party. YouTube star Jimmy Dore has ignited an intra-party firestorm by arguing that progressive members of the US House of Representatives should threaten not to support House Speaker Nancy Pelosi (D-CA) in her bid to remain leader of the chamber unless she promises to bring "Medicare for All" to a vote.Danny Sjursen, retired US Army major and author of "Patriotic Dissent: America in the Age of Endless War," returns to discuss the violence and devastation in the Tigray Region of Ethiopia. Sjursen has written an outstanding piece about the violence in which he outlines the ethnic conflicts and other critical issues at the core of the struggle.Kevin Gosztola, managing editor of Shadowproof.com returns to discuss the plight of WikiLeaks co-founder Julian Assange. In light of the recent plea from the American Civil Liberties Union (ACLU) for US President Donald Trump to pardon Edward Snowden, we discuss the importance of adding Assange's name to the list of those who deserve to be relieved of the US/EU empire's extralegal assault on whistleblowers. Also, we discuss a report that Hollywood star Pamela Anderson has reached out to the president to request clemency for Assange.Ted Rall, political cartoonist and syndicated columnist, joins us to discuss dramatic proposed changes and additions to tech laws in the European Union. While these changes may appear just and warranted on the surface, below the surface lie a number of troubling proposals that could increase censorship and make it more difficult to remove sanctions from identified adversaries.Dr. Gerald Horne, professor of history at the University of Houston, author, historian and researcher, joins us to discuss reports that the incoming Biden administration is considering relaxing some of the draconian US sanctions on Cuba, which were tightened by the Trump administration. Additionally, we talk about the opportunity available for the new administration to reset relations with the island nation and treat it in a just manner. Dr. Kenneth Surin, professor emeritus of literature and professor of religion and critical theory at Duke University; and Dr. Colin Cambell, Washington, DC, senior news correspondent, join us to discuss Surin's brilliant article in CounterPunch, titled "The Brexit Blame Game." Surin adds clarity to the confusing situation when he states, "Both the UK and the EU are engaged in a game of brinkmanship, amounting to a kind of shadow theater — neither wants to shoulder the blame for the UK's exit from the EU without a trade deal between the two."

In Part II of our conversation with Eric, we discuss how he found his way to Vidalia Mills, the next great selvedge denim mill in the United States. In what is sure to become denim folklore in the United States, we hear how he saved dozens of old Draper X3 shuttle looms from the recently closed Cone Mills plant in North Carolina. Hosts: Eric John and Jason Howe - Music credit: Lobo Loco - Intro credit: Ryan Andes https://www.instagram.com/ericgoldstein/ https://www.instagram.com/vidaliamills/

With one of the most extensive backgrounds in raw denim, Eric has done it all. From RRL to Gap to starting his own brand in Jean Shop and even having an HBO series based on his life, we track the evolution of the denim industry through Eric’s background in Part I of our conversation with this denim icon. Hosts: Eric John and Jason Howe - Music credit: Lobo Loco - Intro credit: Ryan Andes https://www.instagram.com/ericgoldstein/

BrotherlyGame.com editor Matt Ralph is joined by writer Eric Goldstein, photographer Carl Gulbish and special guest Keasel Broome to discuss the Union's first home game in 310 days, Mark McKenzie using his platform to call for justice for Jacob Blake, players striking in MLS and other leagues, RSL and Utah Royals terrible reaction and more. Follow Keasel Broome @keasel on Twitter and check out his Keepin' It Real with Keasel podcast Follow Eric Goldstein at @ericesponda on Twitter Follow Carl Gulbish at @carlgulbishpho1 on Twitter Learn more about your ad choices. Visit megaphone.fm/adchoices

Eric Goldstein, author of The Price of Whiteness: Jews, Race, and American Identity, joins Dan Libenson and Lex Rofeberg for a conversation exploring the history of American Jews and their relationship to whiteness. Their conversation looks at the ever-evolving relationship between particularism and universalism for American Jews, contemporary discourse around white Jews and Jews of Color, and more.If you're enjoying Judaism Unbound, please help us keep things going with a one-time or monthly tax-deductible donation. Support Judaism Unbound by clicking here!To access shownotes for this episode, click here.

In episode one, two of America's leading denim experts dive deep into the blue stuff. Featuring Michael Williams founder of A Continuous Lean, and Eric Goldstein founder of Jean Shop. We discuss the origins of denim, how the industries have evolved to be more sustainable, and why so many continue love, repair and wear the humble cotton jean.**From MR PORTERHow To Look After Your Jeans**Follow Us:MR PORTERTwitterFacebookInstagram

The heavy rain on July 22 caused havoc across New York City, quickly flooding subway stations, streets and freeways. One Brooklyn woman even got out of her car and helped unclog several sewer grates on the Long Island Expressway — all while wearing Crocs.

Complete clean electricity by 2050. Mandatory collection of compost citywide. Carbon neutrality for all large buildings. Those were only some of the many promises touted in Mayor Bill de Blasio's announcement of New York's Green New Deal this week. Gov. Andrew Cuomo also signed historic legislation on Earth Day to ban single-use plastic bags. Our reporter Scott Enman is going to break all of this down for us. Plus, we’ll be hearing from Eric Goldstein at the Natural Resources Defense Council and John Lipscomb of Riverkeeper. Lastly, our reporter Paul Frangipane goes inside a Sunset Park recycling plant. Interview with Scott Enman at 1:11Interview with John Lipscomb at 5:23Interview with Eric Goldstein at 11:06Interview with Paul Frangipane at 14:53Our host Lawrence Madsen is a native New Yorker. His family and friends have told him since he was 17 that he has a voice for radio. When he saw an opportunity to do just that, he jumped for it. He is dearly fond of the Brooklyn Eagle. He attended Columbia University, and volunteers with the disaster relief group Team Rubicon.Subscribe to Brooklyn this Week:iTunesSpotifyStitcher

You might if no one else wants to do the things your confident will drive business in the future. Because you can only wait so long before that unattained success starts to permanently slow you down. Once you're free it's about dedicating yourself to creating enough helpful content a specific industry can't ignore. Then it's just a matter of sticking around long enough see the value you built continue to grow. That's what I talk to Eric Goldstein, of G5 Insurance, about his recent departure and the success that's followed it.

You might if no one else wants to do the things your confident will drive business in the future. Because you can only wait so long before that unattained success starts to permanently slow you down. Once you're free it's about dedicating yourself to creating enough helpful content a specific industry can't ignore. Then it's just a matter of sticking around long enough see the value you built continue to grow. That's what I talk to Eric Goldstein, of G5 Insurance, about his recent departure and the success that's followed it.

By Jackie DavisToday we'll be talking about particular ways the mutable American Jewish identity has been formed by (and forms) race.----Do you know that sound? The heartbeat rhythm, the call to Zion… What comes to your mind when you think of Bob Marley? Jamaica? Rastafarianism? Reggae? Judaism? I’m willing to bet that last one was a bit of a surprise. As it was for me. Iconic Jamaican singer-songwriter Bob Marley (born in 1945) was in fact the son of Norval Marley, a white British-Jamaican with reported Iberian/Syrian Jewish ancestry. His mother was Cedella Booker, an Afro-Jamaican descended from Akan slaves of the African Gold Coast. To be clear, Bob Marley was certainly not a practicing Jew, as far as I can tell, or technically Jewish under matrilineal Halakha law, but his family story does tell an integral tale of Jewish history related to changing conceptions of race in the Americas. And when I say race, I will particularly focus on the construction, performance and utility of whiteness in modern times. So often in today’s racial discourse race is defined in terms of People of Color, but race is also about whiteness. All people are raced. And when it comes to Jewish identity, with its own complicated, ambivalent connection to race (Think: Is Judaism a race? Is it a religion? A culture? An ethnicity?), looking at Jewishness in relationship to whiteness makes manifest certain aspects of what Jewishness, whiteness and even race mean in specific times. More importantly, differing Jewish histories in the Americas point out what Jewishness, whiteness and racial identity do in certain contexts. Let us think of both Jewishness and whiteness not as static identities, but as elastic categories. In this podcast we will explore differing attitudes towards race throughout colonial histories, and how the racially malleable Jewish identity is a prime example of an identity that resists a fixed racial categorization. From here we can come to understand subtleties around race, and particularly whiteness as a process. We will compare Laura Liebmans’ research on multi-ethnic, creolized Caribbean Jews to Eric Goldstein’s research on how Jews became white over the course of the 20th century in the United States. By looking at these two scholar’s works side-by-side, we can see, through Jewishness, how whiteness is, first of all, an unstable category and then secondly a homogenizing mode of social control.ReferencesBen-Ur, Aviva. “Atlantic Jewish History: A Conceptual Reorientation.” (2014), from the Selected Works of Aviva Ben-Ur, University of Massachusetts—Amherst (http://works.bepress.com/aviva_benur/20/)Casteel, Sarah Phillips. Calypso Jews: Jewishness in the Caribbean Literary Imagination. New York: Columbia University Press, 2016.Goldstein, Eric. The Price of Whiteness: Jews, Race, and American Identity. Princeton: Princeton University Press, 2006.Laura Leibman interview (https://blogs.brandeis.edu/freshideasfromhbi/interview-with-laura-leibman-judaism-and-the-mutability-of-race-in-colonial-era-america/)Sorkin, David. “The Port Jew: Notes Toward a Social Type.” Journal of Jewish Studies, Vol L, No. 1, Spring 1999.

This week on the podcast, Federation President & CEO Jay Sanderson talks to Eric Goldstein, CEO of UJA-Federation NYC, the Los Angeles Federation’s East Coast cousin. They speak about the role of the Federation today, the difficulties they face during challenging times, and what we need to do to bring our Jewish communities together.

Today's episode of Let There Be Talk will be a "Handmade Edition" with my guest Eric Goldstein Owner of the incredible Denim shop in NYC called JEAN SHOP. I met Eric back in 2005 at his shop and fell in love with his Denim and Leather goods  immediately. Eric built his Denim company from the ground up and today JEAN SHOP is known as one of the best Denim lines in the US. For all the listeners of this episode Eric has a special 20% OFF code until July 5th 2017 for his online store of call the shop 212 366 5326 Discount code is crosby3year for online shopping at worldjeanshop.com     

Award-winning chef Bill Telepan fights for fresh food in the New York City public schools while working with Eric Goldstein, CEO of The New York City Public School's Office of School Support Services, who feeds 1 Million kids per day.

Eating Matters is back for a new radio season! Host Kim Kessler is joined by Doug Davis (School Nutrition Association), Margo Wootan (Center for Science in the Public Interest), Kathy Lawrence (School Food Focus), and Eric Goldstein (NYC Department of Education) to discuss the scope and scale of the school lunch program and exactly what is at stake as current policy issues arise. With an ongoing discussion revolving around the SNA requesting flexibility with implementing school lunch standards, increased lunch funding, and the concept of universal meals, today’s guests bring a great deal of insight to the situation. Tune in for a great debate on how best to achieve success in the school lunch realm. This program was brought to you by The International Culinary Center. “Lunch period and breakfast are two very important health classes that the kids should have everyday. We have to rethink how we treat lunch and breakfast as part of the school day.” [14:00] –Eric Goldstein on Eating Matters    

The Urban School Food Alliance (Alliance), a coalition of the largest school districts in the United States that includes New York City, Los Angeles, Chicago, Miami-Dade, Dallas and Orlando, announced that it will start rolling out the use of compostable round plates at cafeterias this month, saying good-bye to polystyrene trays. The districts in the Alliance serve 2.5 million meals a day, and the six districts project to remove 225 million polystyrene trays from landfills every year. Tune in as we speak with the Chairman of the Alliance, Eric Goldstein, and the director of Natural Resource Defense Council's New York urban program and senior attorney, Mark Izeman.

Things are changing quickly in the chicken industry. The Urban School Food Alliance, a coalition of the largest school districts in the United States that includes New York City, Los Angeles, Chicago, Miami-Dade, Dallas and Orlando, recently announced an antibiotic-free standard for companies to follow when supplying chicken products to its schools. Katy Keiffer digests this news with a great panel of guests on both sides of the industry on this week’s episode of What Doesn’t Kill You. She’s joined by Dr. John Glisson, Vice President of research at the US Poultry & Egg Association in Tucker, Georgia, Eric Goldstein, Chief Executive of the Office of School Support Services and Mark Izeman, Director, New York Urban Program, Senior Attorney, Food & Agriculture and Senior Attorney, Urban Program at the Natural Resources Defense Council. This program was brought to you by Cain Vineyard & Winery. “The cost of producing chicken will go up soon as a result of this [The Urban School Food Alliance announcement]” [16:00] –Dr. John Glisson on What Doesn’t Kill You “We came to the realization there’s an overuse of non therapeutic antibiotics in the poultry sector. That’s just something we don’t like.” [25:00] –Eric Goldstein on What Doesn’t Kill You “As the scientific evidence mounts, industry groups often tend to splinter.” [37:00] –Mark Izeman on What Doesn’t Kill You

Things are changing quickly in the chicken industry. The Urban School Food Alliance, a coalition of the largest school districts in the United States that includes New York City, Los Angeles, Chicago, Miami-Dade, Dallas and Orlando, recently announced an antibiotic-free standard for companies to follow when supplying chicken products to its schools. Katy Keiffer digests this news with a great panel of guests on both sides of the industry on this week’s episode of What Doesn’t Kill You. She’s joined by Dr. John Glisson, Vice President of research at the US Poultry & Egg Association in Tucker, Georgia, Eric Goldstein, Chief Executive of the Office of School Support Services and Mark Izeman, Director, New York Urban Program, Senior Attorney, Food & Agriculture and Senior Attorney, Urban Program at the Natural Resources Defense Council. This program was brought to you by Cain Vineyard & Winery. “The cost of producing chicken will go up soon as a result of this [The Urban School Food Alliance announcement]” [16:00] –Dr. John Glisson on What Doesn’t Kill You “We came to the realization there’s an overuse of non therapeutic antibiotics in the poultry sector. That’s just something we don’t like.” [25:00] –Eric Goldstein on What Doesn’t Kill You “As the scientific evidence mounts, industry groups often tend to splinter.” [37:00] –Mark Izeman on What Doesn’t Kill You

"The Future of Women's Rights, Minority Rights, and Freedom of Expression in Tunisia" Featuring: Dr. Nejib Ayachi, Mr. Eric Goldstein, Ms. Naziha Réjiba, and Dr. Nancy Okail. Recorded March 5, 2013 in Washington, DC. Visit www.ncusar.org for more information.

The process of drilling for natural gas, commonly known as hydraulic fracturing or fracking, continues to be a polarizing issue in communities across the country. Fracking has the potential to provide a domestic source of energy that pollutes less than coal and petroleum when burned. The practice would also provide jobs and income to thousands in many economically depressed areas. This program provides a panel for discussion over the debate between environmental concerns and job availabilities. Sponsored by Zicklin School of Business, the program starts with an introduction by Michael Blah from Sustainability Practice Network, a partner to this program. It is moderated by Christine Farias, Professor, Baruch Business School of the Department Economics and Finance. The panelists include Thomas J. Shepstone, Campaign Director, Energy In Depth-Northeast Marcellus Initiative; Bridget Lee, Associate Attorney in Earth Justice; Eric Goldstein, National Resource Defense Council; and Walter Hang, Toxics Targeting

The process of drilling for natural gas, commonly known as hydraulic fracturing or fracking, continues to be a polarizing issue in communities across the country. Fracking has the potential to provide a domestic source of energy that pollutes less than coal and petroleum when burned. The practice would also provide jobs and income to thousands in many economically depressed areas. This program provides a panel for discussion over the debate between environmental concerns and job availabilities. Sponsored by Zicklin School of Business, the program starts with an introduction by Michael Blah from Sustainability Practice Network, a partner to this program. It is moderated by Christine Farias, Professor, Baruch Business School of the Department Economics and Finance. The panelists include Thomas J. Shepstone, Campaign Director, Energy In Depth-Northeast Marcellus Initiative; Bridget Lee, Associate Attorney in Earth Justice; Eric Goldstein, National Resource Defense Council; and Walter Hang, Toxics Targeting

The process of drilling for natural gas, commonly known as hydraulic fracturing or fracking, continues to be a polarizing issue in communities across the country. Fracking has the potential to provide a domestic source of energy that pollutes less than coal and petroleum when burned. The practice would also provide jobs and income to thousands in many economically depressed areas. This program provides a panel for discussion over the debate between environmental concerns and job availabilities. Sponsored by Zicklin School of Business, the program starts with an introduction by Michael Blah from Sustainability Practice Network, a partner to this program. It is moderated by Christine Farias, Professor, Baruch Business School of the Department Economics and Finance. The panelists include Thomas J. Shepstone, Campaign Director, Energy In Depth-Northeast Marcellus Initiative; Bridget Lee, Associate Attorney in Earth Justice; Eric Goldstein, National Resource Defense Council; and Walter Hang, Toxics Targeting