Podcasts about nrf1

Welcome to "Thriving in Midlife Redefining Aging with Wellness" the podcast where we discuss how to live an extraordinary life in every aspect. I'm your host, Kellie Lupsha, a high-performance health coach, who is delighted to be your guide to vitality.In this episode, I discuss the news of Dr. Casey Means' nomination for Surgeon General and what it means for the future of metabolic and cellular health. I break down key concepts like mitochondrial function, oxidative stress, and inflammation—and how activating your body's natural pathways can transform your health.Whether you're just starting your wellness journey or looking to deepen your knowledge, this episode offers actionable insights to boost energy, longevity, and overall vitality.Key Highlights:The announcement of Dr. Casey Means' Surgeon General nomination and why it's a pivotal moment in health and wellness.An inside look at how mitochondrial function, oxidative stress, and inflammation play a role in how you feel and age.Discover what “activation” really means—and why it's more than just another buzzword when it comes to metabolic health.The key biological pathways like NRF2, NRF1, and NAD—and how they can be activated to support your body on a cellular level.Learn the five key markers that define metabolic health and why improving them can change your life.Insights on clinically proven tools and products that go beyond diet and exercise to help your body thrive.Key Takeaways"You need to activate your body... it is important... you need to activate it on a daily basis." —Kellie Lupsha“You need to get metabolically healthy... Activation is the solution..” —Kellie Lupsha*FREE GIFT

Is There Gluten Hiding in Your Thyroid Medication?   Could your thyroid medication be making your Hashimoto's symptoms worse?   If you're working hard to manage your Hashimoto's by avoiding gluten, you might be shocked to learn that some thyroid medications, like generic levothyroxine, could contain gluten and other fillers that sabotage your health. In this episode, Esther, a nurse with over 20 years of experience, uncovers this hidden issue and helps you check your medications and supplements.   In this episode, you'll learn: Why some thyroid medications might be harming your Hashimoto's progress. How to check if your medication contains gluten or other harmful fillers. Practical steps to ensure you're getting safe, high-quality medications and supplements. Hit play now to discover how to protect your health and make informed choices for your Hashimoto's journey!   Find all links on my resource page or keep scrolling here: https://healthwithhashimotos.com/resources/   ABOUT THE PODCAST & ESTHER: The Health with Hashimoto's podcast will help you explore the root causes of your autoimmune condition and discover holistic solutions to address your Hashimoto's thyroiditis. It is hosted by Esther Yunkin, a registered nurse, holistic health educator, and Hashimoto's warrior.   This podcast is for informational and educational purposes. Please discuss any questions or concerns with your healthcare professional.   Are you trying to find Hashimoto's answers without more trial and error? Here are ways you can find solutions for your health...   Your Path to Health with Hashimoto's is three simple steps.   >> Step One - Hashimoto's Decoded: 10 Thyroid Questions to Ask Your Doctor Your doctor is on your team to give you the best advice he/she can. Ultimately, your action plan is in your hands. These 10 questions will empower you as a patient and advocate for your own health!   >> Step Two - Hashimoto's Decoded: Root Causes Revealed In order to make a difference in your Hashimoto's healing journey, you must know what is causing the problems. This mini course will give you an understanding your own root causes.   >> Step Three - The Holistic Hashimoto's Course Save time and energy as I guide you through the best ways to address your root causes. This is your most streamlined way to take control of your health and feel like yourself again.   >> Holistic Hashimoto's Coaching Sessions are available any time you need to get unstuck in your health and develop an action plan that will work with your current realities of life (time, stress, etc.)   >> Activate your health - LifeVantage The Dual Synergizer turns your Nrf2 pathway back on and increases your own antioxidant production including 300x more glutathione. It also activates your Nrf1 pathway to make more mitochondria (energy.) The Rise & Reset multinutrient system is the best "multivitamin" I've found. The MindBody GLP-1 System gets your body making and maintaining healthy levels of GLP-1 so you can balance your hormones and lose weight.    >> All other supplements - Fullscript is an online store where you can find over 20,000 products to support your wellness goals. Find “Esther's Favorites” under the catalog tab.

In this deep-dive episode of The Red Light Report, Dr. Mike Belkowski takes you beyond the basics to explore why mitochondrial function is the true driver of health—and disease. After contrasting centralized vs. decentralized health paradigms, he reveals the root causes and systemic effects of mitochondrial dysfunction, using vivid analogies like “rocks in a river” to explain electron leakage and oxidative stress. From there, Mike unpacks the Six Pillars of Mitochondrial Health: 1. Energy Production – ATP synthesis & structured “EZ” water batteries 2. Biogenesis – Growing new mitochondria via PGC-1α, NRF1/2, TFAM 3. Mitophagy – Recycling damaged mitochondria through PINK1/Parkin 4. Fusion/Fission – Dynamic balancing of mitochondrial networks 5. Oxidative Stress Protection – Internal and supplemental antioxidants 6. Light Interaction – How red/NIR light supercharges bioenergetics   Along the way, learn why methylene blue and red light therapy are synergistic brain- and mitochondria-boosters, why proper breathing and oxygen availability are non-negotiable, and how lifestyle tactics—from grounding to sun exposure—tie back to cellular power. Mike closes with a sneak peek at an upcoming all-in-one mitochondrial optimization product designed to tackle all six pillars at once. If you found the information in today's episode particularly interesting and/or compelling, please share it with a family member, friend, colleague and/or anyone that you think could benefit and be illuminated by this knowledge. Sharing is caring :) As always, light up your health! - 00:00 – Introduction: Mitochondrial Health & Podcast Focus 02:14 – Centralized vs. Decentralized Health Paradigms 03:43 – Mitochondrial Dysfunction: Causes and Effects 05:11 – Six Pillars of Mitochondrial Function Overview 07:39 – Pillar 1: Energy Production (ATP & EZ Water) 09:02 – Methylene Blue: Brain Boost + Mitochondrial Synergy 19:15 – Root Causes of Disease via Mitochondrial Dysfunction 20:11 – Electron Transport Chain Analogy (Rocks in a River) 26:47 – Importance of Breathing & Oxygen for Mitochondria 28:19 – Pillar 2: Mitochondrial Biogenesis 33:25 – Pillar 3: Mitophagy (Mitochondrial Cleanup) 39:24 – Pillar 4: Mitochondrial Fusion & Fission 43:08 – Pillar 5: Free Radical & Oxidative Stress Protection 48:11 – Antioxidants: Internal & External Defenses 52:18 – Pillar 6: Light's Impact on Mitochondria 58:29 – Light = Battery for Cells: Red/NIR Light & EZ Water 59:20 – Recap: The Six Pillars of Mitochondrial Health 01:00:17 – Tease for New Product: Optimizing All Six Pillars 01:02:13 – Final Thoughts: Pursuing the Mitochondrial Fountain of Youth - Upcoming BioLight Events:   Biohacking Conference - May 28 - 30 (Austin, TX)   Returning to Nature (Quantum Health Retreat), June 26 - 27 (Franklin, TN) - Save 25% when you Subscribe & Save to a BioBundle!   For a BioBundle, you choose:1.) Any one BioBlue supplement(BioBlue, BioBlue (SR), BioBlue Leuco, BioBlue Calm, BioBlue Capsules or BioBlue Leuco Capsules)2.) Any one BioC60 supplement(Regular or Concentrated)   The BioBundle automatically saves you 15% on both of the supplements you choose.You save an additional 10% by choosing to Subscribe & Save to that BioBundle.The 25% savings is passed along for every monthly delivery of your BioBundle!No discount code necessary!   Click here to check out The BioBundle - Dr. Mike's #1 recommendations: Water products: Water & Wellness Grounding products: Earthing.com EMF-mitigating products: Somavedic Blue light-blocking glasses: Ra Optics - Stay up-to-date on social media: Dr. Mike Belkowski: Instagram LinkedIn   BioLight: Website Instagram YouTube Facebook

Today I am sharing about the hairloss situation I was going through this past year. While it wasn't particularly fun something incredible did come from it. Listen in to hear about it now!   Thank you so much for being here! I am so happy to have you and hope this podcast provides you with the resources you need as you navigate the complicated world of acne, skin health, gut health, wellness and more!  I would love to connect with you over on IG @detoxingwithdani   Links from today's episode: Learn more about the NRF1 and NRF2 HERE  Join the Wellness Warriors Facebook Group HERE Check out Cozy Earth Pajamas and Sheets HERE - dont' forget to use code DETOXING for 40% off    Let's Connect! You can find me on IG @detoxingwithdani or join our private facebook group HERE    MEDICAL & HEALTH DISCLAIMER: The information and other content provided in this podcast, page, or in any linked materials, are not intended and should not be construed as medical advice, nor is the information a substitute for professional medical expertise or treatment.   If you or any other person has a medical concern, you should consult with your health care provider or seek other professional medical treatment. Never disregard professional medical advice or delay in seeking it because of something that you have heard on this podcast or in any linked materials. If you think you may have a medical emergency, call your doctor or emergency services immediately.

Today's episode is diving into how we can support our bodies and gut to produce the natural GLP-1 that is supposed to be there and the benefits no one is talking about. Our bodies were made perfect, we just need to remind them and activate the right systems to do what they were designed to do. Just like a car, the car doesn't move in the right direction without the assistance of the driver. That is our body, it knows what to do but it needs our assistance in telling in what to do and when to do that. Today I am going to dive into how we can instruct our bodies to produce the natural GLP-1 for optimal digestion, a healthy gut and glowing skin.    Links from today's episode: Learn more about the GLP-1 MindBody system HERE  Learn more about the NRF1 and NRF2 HERE  Learn more about the Skin Freedom Masterclass HERE  Check out Cozy Earth Pajamas and Sheets HERE - dont' forget to use code DETOXING for 40% off    Let's Connect! You can find me on IG @detoxingwithdani or join our private facebook group HERE    MEDICAL & HEALTH DISCLAIMER: The information and other content provided in this podcast, page, or in any linked materials, are not intended and should not be construed as medical advice, nor is the information a substitute for professional medical expertise or treatment.   If you or any other person has a medical concern, you should consult with your health care provider or seek other professional medical treatment. Never disregard professional medical advice or delay in seeking it because of something that you have heard on this podcast or in any linked materials. If you think you may have a medical emergency, call your doctor or emergency services immediately.

What are the best supplements for Hashimoto's? With over 20,000 products available to you, how do you know what vitamins or herbs are helpful if you have Hashimoto's disease? In this episode, Esther guides you through what is most important to support your body if you have an autoimmune disease. Support your health by following this simple plan.   I take supplements for two reasons. The first is to activate my own body to do something (like create antioxidants, make more collagen, and reduce oxidative stress.) The second is to fill gaps in my diet/life (vitamin D, minerals, adaptogens, etc.) I covered some of this in episode 3 of the Health with Hashimoto's podcast.     Products: Activation Company for Nrf2, Nrf1, GLP-1, Collagen, time-wise Rise & Reset, and more Esther's Fullscript Link for over 20,000 products to support your wellness goals     JOIN THE COMMUNITY Unlock your wellness journey with the free Health with Hashimoto's community! Join a supportive community that's here for you every step of the way.  Our community is now on Skool: https://www.skool.com/health-with-hashimotos/about       YOUR PATH TO HEALTH WITH HASHIMOTO'S   STEP 1 - Hashimoto's Decoded: 10 Thyroid Questions to Ask Your Doctor. https://healthwithhashimotos.com/questions-for-your-doctor/   STEP 2 - Hashimoto's Decoded: Root Causes Revealed. https://hwh.passion.io/checkout/157602    STEP 3: The Holistic Hashimoto's Course https://healthwithhashimotos.com/holistic-hashimotos-course/      ABOUT THE PODCAST & ESTHER: The Health with Hashimoto's podcast will help you explore the root causes of your autoimmune condition and discover holistic solutions to address your Hashimoto's thyroiditis. It is hosted by Esther Yunkin, a registered nurse, holistic health educator, and Hashimoto's warrior.   This podcast is for informational and educational purposes. Please discuss any questions or concerns with your healthcare professional.

Join us on 'Health With Hashimoto's' podcast where we dissect the supplement industry. Gain insight into its undulating landscape and learn how to navigate it with efficacy. This episode aims at disclosing the truth about supplements, notably discussing the rationale behind reconsidering purchases from Amazon, the struggle in validating supplement authenticity, the health hazards associated with counterfeit supplements, and the varying standards within network marketing companies. We introduce you to Fullscript, a dependable platform focused on delivering high-quality supplements. The company's commitment to purity and potency comes to light through their examination of magnesium products, revealing startling facts about the market's label claims. We also look into other vital supplements such as glutathione, NRF2 and NRF1 activators, and humic and fulvic acid, discussing the way they work with our bodies at a cellular level. Each supplement recommendation comes from meticulous product appraisals and exhaustive research. Our experience, combined with strict endorsement criteria, ensures recommendations that benefit you. However, gaining access to Fullscript isn't without its specifics and this is discussed in detail. We wrap up the episode by providing a glimpse into our host's daily intake of health supplements, underlining why each one holds a crucial place in her regimen. The emphasis is on making informed health decisions by equipping yourself with knowledge through this enlightening episode of the 'Health With Hashimoto's.' Please consult with your trusted healthcare professional for your health-related concerns. This podcast serves informational and educational purposes only.

BUFFALO, NY- April 9, 2024 – A new #researchpaper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 6, entitled, “CMS121: a novel approach to mitigate aging-related obesity and metabolic dysfunction.” Modulated by differences in genetic and environmental factors, laboratory mice often show progressive weight gain, eventually leading to obesity and metabolic dyshomeostasis. The geroneuroprotector CMS121 has a positive effect on energy metabolism in a mouse model of type 2 diabetes. In this new study, researchers Alcir L. Dafre, Saadia Zahid, Jessica Jorge Probst, Antonio Currais, Jingting Yu, David Schubert, and Pamela Maher from Salk Institute for Biological Studies, National University of Sciences and Technology (NUST) and Federal University of Santa Catarina investigated the potential of CMS121 to counteract the metabolic changes observed during the ageing process of wild type mice. “This comprehensive analysis aimed to further understand how CMS121 influences the metabolic landscape, paving the way for potential therapeutic applications beyond its established geroneuroprotective benefits.” Control or CMS121-containing diets were supplied ad libitum for 6 months, and mice were sacrificed at the age of 7 months. Blood, adipose tissue, and liver were analyzed for glucose, lipids, and protein markers of energy metabolism. The CMS121 diet induced a 40% decrease in body weight gain and improved both glucose and lipid indexes. Lower levels of hepatic caspase 1, caspase 3, and NOX4 were observed with CMS121 indicating a lower liver inflammatory status. Adipose tissue from CMS121-treated mice showed increased levels of the transcription factors Nrf1 and TFAM, as well as markers of mitochondrial electron transport complexes, levels of GLUT4 and a higher resting metabolic rate. Metabolomic analysis revealed elevated plasma concentrations of short chain acylcarnitines and butyrate metabolites in mice treated with CMS121. “The diminished de novo lipogenesis, which is associated with increased acetyl-CoA, acylcarnitine, and butyrate metabolite levels, could contribute to safeguarding not only the peripheral system but also the aging brain. By mimicking the effects of ketogenic diets, CMS121 holds promise for metabolic diseases such as obesity and diabetes, since these diets are hard to follow over the long term.” DOI - https://doi.org/10.18632/aging.205673 Corresponding authors - Pamela Maher - pmaher@salk.edu and Alcir L. Dafre - alcir.dafre@ufsc.br Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.205673 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts About Aging-US Aging publishes research papers in all fields of aging research including but not limited, aging from yeast to mammals, cellular senescence, age-related diseases such as cancer and Alzheimer's diseases and their prevention and treatment, anti-aging strategies and drug development and especially the role of signal transduction pathways such as mTOR in aging and potential approaches to modulate these signaling pathways to extend lifespan. The journal aims to promote treatment of age-related diseases by slowing down aging, validation of anti-aging drugs by treating age-related diseases, prevention of cancer by inhibiting aging. Cancer and COVID-19 are age-related diseases. Please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

What are the best supplements for Hashimoto's? With over 20,000 products available to you, how do you know what vitamins or herbs are helpful if you have Hashimoto's disease? In this episode, Esther guides you through what is most important to support your body if you have an autoimmune disease. Support your health by following this simple plan. See the chart here: https://healthwithhashimotos.com/supplements-for-hashimotos/   Products: Activation Company for Nrf2, Nrf1, Collagen, time-wise Rise & Reset, and more Esther's Fullscript Link for over 20,000 products to support your wellness goals BlackMP for fulvic and humic acids with probiotics and 77 trace minerals   Related Episodes: Episode 4: Are there natural remedies for Hashimoto's disease? Episode 37: I need more energy!   KNOW EXACTLY WHAT TO ASK YOUR DOCTOR: Know exactly what questions to ask at your next doctor's appointment with this list. This free PDF includes a printable page with all the questions listed as well as information for you so you can learn why each question matters. https://healthwithhashimotos.com/questions-for-your-doctor/   THE HOLISTIC HASHIMOTO'S COURSE: Are you grappling with the fatigue, brain fog, or weight struggles of Hashimoto's thyroiditis? Now, there's a solution! The Holistic Hashimoto's Course will guide you in uncovering your autoimmune root causes and taking clear, simple, and sustainable steps so you can regain your energy and feel like yourself again. https://healthwithhashimotos.com/holistic-hashimotos-course/   About This Podcast and Esther: The Health with Hashimoto's podcast will help you explore the root causes of your autoimmune condition and discover holistic solutions to address your Hashimoto's thyroiditis. It is hosted by Esther Yunkin, a registered nurse, holistic health educator, and Hashimoto's warrior.   This podcast is for informational and educational purposes. Please discuss any questions or concerns with your healthcare professional.

This week is a simple tip on how to move from feeling resentful and stuck to feeling more grateful and spacious.  It can be as simple as changing one word.  Don't believe me?  Take a listen and see what you think.  Interested in the little yellow activator (aka Protandim Nrf2 Synergizer) from the commercial? Check it out here.Other amazing products that I recommend are the liquid collagen, fish oil, probiotic, and the NAD and Nrf1.

Tess Jewell-Larsen is certified mindfulness coach and teaches how to best catch limiting beliefs and reframe them. She is trained in Yoga Nidra and meditation, and shares  how to rest and heal the body from the inside out. Through her own experiences with anxiety and burnout, along with working with others who are also struggling with similar issues, she has developed a vast toolkit of tried, tested and science-backed techniques that I know will also help you step out of your own negative cycles of stress, anxiety, and burnout.Website: https://tessjewelllarsen.coach/ Freebie (10-Minute Method Stepping Out of Burnout): https://tessjewelllarsen.coach/freebie/ Podcast: https://www.tytoniyoga.com/pages/thehappyeditpodcastInstagram: https://www.instagram.com/tessjewelllarsen/ LinkedIn: https://www.linkedin.com/in/tessjewelllarsen/Facebook: https://www.facebook.com/tessjewelllarsencoaching Interested in the little yellow activator (aka Protandim Nrf2 Synergizer) from the commercial? Check it out here.Other amazing products that I recommend are the liquid collagen, fish oil, probiotic, and the NAD and Nrf1.

This is a new revelation for me.  Yes, we can help our own wellness with good habits, tending to our mental health, and rest, among others.  But when you are drowning in burnout, it is not the time nor the place to be taught how to help yourself.  We need the help of someone else at that point in time to jump in and give us a hand and pull us out so we can rest.  That is what I haven't seen in medicine.  We are missing the people that are supposed to be looking after the medical workers. Why is this?  My direct reports are drowning also.  They can't save anyone if they are barely keeping their head above water.  Interested in the little yellow activator (aka Protandim Nrf2 Synergizer) from the commercial? Check it out here.Other amazing products that I recommend are the liquid collagen, fish oil, probiotic, and the NAD and Nrf1.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.06.29.547114v1?rss=1 Authors: Kaya, H. E. K., Ward, M. A., Vangala, J. R., Byers, H. A., Diaz, A., Kaushik, S., Cuervo, A. M., Radhakrishnan, S. K. Abstract: Cells exposed to proteotoxic stress invoke adaptive responses aimed at restoring proteostasis. Our previous studies have established a firm role for the transcription factor Nuclear factor erythroid derived 2-related factor 1 (Nrf1, also called NFE2L1) in responding to proteotoxic stress elicited by inhibition of cellular proteasome. Following proteasome inhibition, Nrf1 mediates new proteasome synthesis, thus enabling the cells to mitigate the proteotoxic stress. Here we report that under similar circumstances, multiple components of the autophagy lysosomal pathway (ALP) are transcriptionally upregulated in an Nrf1-dependent fashion, thus providing the cells with an additional route to cope with proteasome insufficiency. In response to proteasome inhibitors, Nrf1-deficient cells displayed profound defects in invoking autophagy and clearance of aggresomes. This phenomenon was also recapitulated in NGLY1 knockout cells (a model for NGLY1 disease) where Nrf1 is known to be non-functional. Overall, our results significantly expand the role of Nrf1 in shaping the cellular response to proteotoxic stress. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Erin Rocchio walks us through her passion for leading high achieving individuals and teams to become whole at work.  She uses the Enneagram as a tool that gives her clients rich insight into themselves and why they burnout.  She has developed a knowledge, skillset, coaching practice, and a card deck that empowers her clients to understand their burnout and what they need to thrive.  Leaders and managers benefit from this information about themselves, but also about their team members so that they can effectively lead their teams to evolve and excel.The Enneagram Institute RHETI Test: https://tests.enneagraminstitute.com/Wholeness at work:  https://ourwholenessatwork.com/Enneagram Burnout Card Deck click here: https://ourwholenessatwork.com/products/enneagram-x-burnout-card-deckConnect with Erin: erin@evolution.teamEvolution: https://evolution.team/how-we-helpEnneagram in business: https://theenneagraminbusiness.com/Interested in the little yellow activator (aka Protandim Nrf2 Synergizer) from the commercial? Check it out here.Other amazing products that I recommend are the liquid collagen, fish oil, probiotic, and the NAD and Nrf1.

Culture is the water we swim in every day.  It is ubiquitous.  It is powerful and is also hard to wrap your arms around.  So how do we change something as big as an ocean?  This is a question that keeps coming up for me and in this podcast I share this article and my interpretation of it to help with culture.Here is the link to the article I cite in the podcast:https://www.mayoclinicproceedings.org/article/S0025-6196(19)30345-3/fulltextInterested in the little yellow activator (aka Protandim Nrf2 Synergizer) from the commercial? Check it out here.Other amazing products that I recommend are the liquid collagen, fish oil, probiotic, and the NAD and Nrf1.

Sophie Ansari was a 5th grade teacher in Brooklyn, New York and was having panic attacks on her way to work in the morning.  Her mom saw that this was not sustainable and encouraged her to make a change.  Sophie had gone to school for education.  What else could she possibly do?  It took some courage, but Sophie gave herself permission to try something else, something different.  She is now co-hosting the Podcrushed podcast, is an illustrator, and a video creator in Los Angeles.  She has a flexible schedule and loves what she is doing. Listen to Podcrushed podcast here.Interested in the little yellow activator (aka Protandim Nrf2 Synergizer) from the commercial? Check it out here.Other amazing products that I recommend are the liquid collagen, fish oil, probiotic, and the NAD and Nrf1.

Three experiences hit me hard this week and reminded me of three important points that help me with burnout.  This is a reminder to me that I always have a choice, I do not need to react, and I can put better boundaries in place. Interested in the little yellow activator (aka Protandim Nrf2 Synergizer) from the commercial? Check it out here.Other amazing products that I recommend are the liquid collagen, fish oil, probiotic, and the NAD and Nrf1.

In this episode, I interview Dr. Michael Amster, a chronic pain specialist and the co-author of the book The Power of A.W.E. - Overcome Burnout & Anxiety, Ease Chronic Pain, Find Clarity & Purpose — in Less than 1 Minute per Day.  We discuss the research that he and Jake Eagle, LPC have performed surrounding a method to microdose the powerful positive emotion, awe. They knew that mindfulness  improves well-being, reduces stress, anxiety and pain. But for some, the practice itself feels challenging and inaccessible. That's where the A.W.E. Method comes in. In The Power of Awe, Jake and Michael, share their extraordinary yet simple mindfulness practice that turns ordinary moments into awe-inducing experiences, helping you effortlessly achieve a heightened state of consciousness usually reserved for seasoned practitioners of mindfulness—all within a matter of seconds.Explore more at their website https://thepowerofawe.com/Interested in the little yellow activator (aka Protandim Nrf2 Synergizer) from the commercial? Check it out here.Other amazing products that I recommend are the liquid collagen, fish oil, probiotic, and the NAD and Nrf1.

I am reading the book Playing Big by Tara Mohr and I am learning so much about taking a second look at our fear and criticism to help us heal and grow.  I am always amazed when a concept is introduced in a different way how impactful it can be.  I highly recommend this book.  Click here to learn more about the author and the book.Interested in the little yellow activator (aka Protandim Nrf2 Synergizer) from the commercial? Check it out here.Other amazing products that I recommend are the liquid collagen, fish oil, probiotic, and the NAD and Nrf1.

Ashlee Livingstone is the Chief Engagement Officer of Our Forté.  Our Forté is dedicated to creating thriving, sustainable cultures through four cornerstone pillars: Engagement, Development, Gratitude, and Experience.  Ashlee performs one on one and group coaching, one on one targeted breath work, and hypnotherapy to help clients uncover blocks, stories, and beliefs which are holding them back from achieving their personal and professional goals.Connect with Ashlee on her website: https://www.ourforte.ca/Connect with Ashlee on Instagram: https://www.instagram.com/ourforte/Interested in the little yellow activator (aka Protandim Nrf2 Synergizer) from the commercial? Check it out here.Other amazing products that I recommend are the liquid collagen, fish oil, probiotic, and the NAD and Nrf1.

I always want to share with you the new things I have learned and this week I learned about a vulnerability hangover through first hand experience.  As always, I walk you through what this means, what it felt like, and things I did (good and not-so-good) to deal with it.  Interested in the little yellow activator (aka Protandim Nrf2 Synergizer) from the commercial? Check it out here.Other amazing products that I recommend are the liquid collagen, fish oil, probiotic, and the NAD and Nrf1.

Advice critics Kristen Meinzer and Jolenta Greenberg spent years living by and critiquing advice from self-help books for their podcast By The Book.  I am asking them about their burnout and what stuck from all of that self help reading!  They have a new podcast, How To Be Fine,  that discusses wellness-related questions and help debunk all the self-help myths and promises.  Click here to listen: How to Be Fine PodcastInterested in the little yellow activator (aka Protandim Nrf2 Synergizer) from the commercial? Check it out here.Other amazing products that I recommend are the liquid collagen, fish oil, probiotic, and the NAD and Nrf1.

Phew!  This weeks started out tough, but I learned a lot after processing through my shame spiral and how I can improve in the future.  Interested in the little yellow activator (aka Protandim Nrf2 Synergizer) from the commercial? Check it out here.Other amazing products that I recommend are the liquid collagen, fish oil, probiotic, and the NAD and Nrf1.

Amber is a Physician Assistant and Certified Functional Medicine Coach who helps busy professional women who are struggling with burnout and stress-induced behaviors associated with eating. She uses a holistic approach with her clients to manage stress and anxiety, to find relief from the chronic stress state.  She also works to discover the root causes behind food compulsions and cravings, to target these areas directly and restore the body's natural biological processes.Links:Facebook Community - "Banish Burnout & End Emotional Eating"https://www.facebook.com/groups/fittinginfoodFB profile: Amber Benderhttps://www.facebook.com/amber.bender817Website: https://www.ambermbender.comInterested in the little yellow activator (aka Protandim Nrf2 Synergizer) from the commercial? Check it out here.Other amazing products that I recommend are the liquid collagen, fish oil, probiotic, and the NAD and Nrf1.

Here are two stories that I hope resonate with you about how I still have things to work on, but also, how much improvement I have made.  Take a listen and have a laugh.  Interested in the little yellow activator (aka Protandim Nrf2 Synergizer) from the commercial? Check it out here.Other amazing products that I recommend are the liquid collagen, fish oil, probiotic, and the NAD and Nrf1.

Late one night, while Rebecca was alone in her New York apartment, her hand was partially amputated in an explosion.  Quick thinking saved her life, but the journey to recovery would be a slow one.  As doctors rebuilt her hand, Rebecca began rebuilding her sense of self by studying the physical and psychological process of recovery.  Interspersing the personal with the medical, Rebecca charts her year of rehabilitation, touching on the marvelously adaptable anatomy of the hand; how the brain's fight-or-flight mechanism enables us to react instantly to danger; and why trauma causes some people to develop PTSD and gives others a whole new lease on life. Told with emotional and intellectual clarity, BEAUTIFUL TRAUMA is a celebration of the resilience of the human spirit and the power we all hold in our hands.Order Beautiful Trauma here.Interested in the little yellow activator (aka Protandim Nrf2 Synergizer) from the commercial? Check it out here.Other amazing products that I recommend are the liquid collagen, fish oil, probiotic, and the NAD and Nrf1.

When I was SUPER burned out all the self help books were telling me to think about what gave me joy.  Nothing. Nothing was giving me joy and I couldn't even think about something that would give me joy.  How am I supposed to co-create this amazing life when I don't know what makes me happy?  I have been there.  Here is a good place to start.Interested in the liquid collagen from the commercial? Check it out here.Other amazing products that I recommend are the Nrf2, fish oil, probiotic, and the NAD and Nrf1.

This podcast interview with the famous Prince EA is packed with wisdom and simple tips that you can integrate into your day to help with mindset and leaning into being best version of you. Richard Williams, better known as Prince EA, is an American spoken word artist, poet, rapper, filmmaker and speaker.  After graduating Magna Cum Laude from the University of Missouri-St. Louis, he initially pursued a career in hip-hop popularizing the “Make S.M.A.R.T. Cool” movement to promote values like intelligence, free thought, unity, and creativity in hip hop music. In 2014, Prince EA shifted his focus from music to creating motivational spoken word films. His YouTube videos have received over two billion views. He covers a wide range of topics such as environmentalism, race, work-life balance, and spirituality. Prince EA's work is widely recognized including Oprah's Super Soul 100 and Forbes 30 Under 30.He has an amazing new wellness focused podcast called Sauna Sessions with Prince EA where he is joined by special guests in an infrared sauna to have longform conversations focused on the mind, body and spirit.Interested in the liquid collagen from the commercial? Check it out here.Other amazing products that I recommend are the Nrf2, fish oil, probiotic, and the NAD and Nrf1.

Julie is my should sister.  I have known her since high school  and we have been through a lot together including burnout.  She worked as an EMT in a level one trauma center emergency department for twelve years and seven years ago, she said enough, and left medicine.    She now is in charge of employee experience and culture at Ruff Wear, a company that makes outdoor adventure gear for dogs.  She is incredible and has found her passion.  Here are the links to the Enneagram and the Clifton Strength Tests.Interested in the liquid collagen from the commercial? Check it out here.Other amazing products that I recommend are the Nrf2, fish oil, probiotic, and the NAD and Nrf1.

Veronique Ory landed herself in the hospital due to the frantic pace that she was keeping.  How is this possible for a yoga instructor?  She had all the tools surrounding peace and wellness, but we all can easily fall into burnout.  Learn how she took universal lessons and stories and applies them to her practice, teaching, and book Shine On & Off the Mat.  Veronique's website: www.yogawithveronique.comIG: https://www.instagram.com/veroniqueory/FB: https://www.facebook.com/theveroniqueory/Shine On & Off the Mat: https://amzn.to/3Dw2gsLFree gift to your listeners: https://bit.ly/3f3cirUMy Costa Rica retreat at Blue Spirit, June 10-17, 2023 https://veretreat.com/retreat/Interested in the liquid collagen from the commercial? Check it out here.Other amazing products that I recommend are the Nrf2, fish oil, probiotic, and the NAD and Nrf1.

I am a people pleaser, so boundaries sounded scary to me at first, but I want to walk you through the unexpected consequences of the absence and presence of boundaries.  In this episode I will dive into what you will feel when you need to put a boundary in place and the ripple effects of having good (and poor) boundaries.Here is the link to the Brené Brown PDF on Core Values:https://brenebrown.com/resources/dare-to-lead-list-of-values/Interested in the little yellow activator (aka Protandim Nrf2 Synergizer) from the commercial? Check it out here.Other amazing products that I recommend are the liquid collagen, fish oil, probiotic, and the NAD and Nrf1.

Dr. JB, who is also known as the metaverse doc, describes how her connections formed outside of the constraints of our workday can help medical workers heal.  She has created a safe space that welcomes all licensed medical personnel to connect, share, grow, learn, and help one another.  IG: @hope4medVisit the Hope4Med website here.Become a member of Hope4Med here for access to the metaverse.Want to discover how to improve the health of your immune system, cardiovascular system, bones, and teeth health through supplementation with Vitamin D?  Click here to learn more!Interested in glowing, hydrated, soft supple skin?  Liquid collagen has helped bring the natural beauty of my skin back to life! Check it out here.Other amazing products that I recommend are the Nrf2, fish oil, probiotic, and the NAD and Nrf1.

Aleece Fosnight PA-C is the CEO and founder of The Fosnight Center for Sexual Health in Asheville, North Carolina.  In this episode, we discuss how intimacy is often a casualty of burnout.Explore her amazing practice here - The Fosnight Center.Connect with her on instagram here - @fosnightcenter.Interested in the liquid collagen from the commercial? Check it out here.Other amazing products that I recommend are the Nrf2, fish oil, probiotic, and the NAD and Nrf1.

Aleece Fosnight is a person who lights up a room with her energetic spirit, but opening a practice during an epidemic, really took a toll on her.  In this episode she walks through her burnout and what she has done to help her feel better.Explore her amazing practice here - The Fosnight Center.Connect with her on instagram here - @fosnightcenter.Interested in the little yellow activator (aka Protandim Nrf2 Synergizer) from the commercial? Check it out here.Other amazing products that I recommend are the liquid collagen, fish oil, probiotic, and the NAD and Nrf1.

When Scott Widenmaier left high school, he wasn't sure what career path he wanted to pursue. He grew up in Alameda, Saskatchewan, and soon found work on oil rigs. But by the time he was in his early twenties, he knew it was time for a change. "I realized that winters are just too cold to continue doing that," said Widenmaier. "I wasn't sure what I was going to do with my life, but I was interested in biology and human physiology." In his third year as a science major at the University of Regina, he became fascinated by a lab experiment examining how neurotransmitters control heart rates. He then moved west, to graduate studies at the University of British Columbia, studying endocrinology and its role in diabetes. "I really like the elegance of the feedback circuits," said Widenmaier, who went on to land a post-doctoral position with Dr. Gökhan Hotamisligil at Harvard University's School of Public Health. As he discovered the emerging field of immunometabolism, Widenmaier began to see links between the way the gut and the human immune system talk to each other, especially around obesity. "That communication to the immune systems and the metabolic systems is dysfunctional and contributes to a lot of the diseases that we see linked to obesity," said Widenmaier, who studies the way the body manages cholesterol. That's the focus of his work at the University of Saskatchewan as an assistant professor in the College of Medicine's department of Anatomy, Physiology and Pharmacology. "There's this transcription factor that sits in a part of the cell and it recognizes when cholesterol's too high," he said. "It changes where it goes in the cell and it regulates a response by the cell to try to prevent the cholesterol from causing damage and stress." Widenmaier has now landed a number of awards, including the Heart and Stroke Foundation's National New Investigator Award in 2020/21. Widenmaier was also named that year's McDonald Scholar. "We've made a lot of progress with understanding the role of NRF1 and NRF2 in the liver," he said. "We've identified some molecules that may be important for protecting cells from too much cholesterol." In this episode, hear how this work has implications for patients with heart and stroke disease, obesity, liver disease, degenerative brain conditions, as well as various forms of cancer.  "The issue with cholesterol is that we absolutely need it, but we also need it to be exactly the right amount," said Widenmaier. "There's lots of times where that that capacity gets stretched, especially under conditions of obesity." "What are those natural adaptive systems? If we can find out what they are, can we make them work better?"

TAGS:#lifescience #health #careforyourbody*ps - the audio quality messes up some during our interview :) 

The NR F1 Podcast bring you Edition 289. We're back catching up on the events from the Abu Dhabi GP and reviewing the 2021 F1 season. Richard Baxter hosts our end of season special with a bumper podcast panel, including the return of our very own Michael Bailey! For more of our content, head over to http://www.patreon.com/nrf1 *** The British county of Norfolk is where the iconic success of Team Lotus was cultivated, where Ayrton Senna, Graham Hill, Martin Brundle, Mark Webber, George Russell and more honed their race craft - and home to The NR F1 Podcast. Find all you need to know about The NR F1 Podcast and how to join in with the fun by visiting our website: http://nrf1.uk  JOIN THE CLUB | Become an NR F1 Podcast patron to enjoy a host of exclusive content: http://patreon.com/nrf1  SUBSCRIBE | Find your podcast player link: http://nrf1.uk/podsubscribe  ITUNES | Subscribe, rate and review us: http://nrf1.uk/isonitunes  GOOGLE PLAY | Likewise: http://nrf1.uk/isongoogleplay  RSS | For android and other devices via audioBoom: https://audioboom.com/channels/4785441.rss  GET IN TOUCH | Follow our social media feeds and join the fun:  TWITTER | http://twitter.com/thenrf1  FACEBOOK | http://fb.me/thenrf1  INSTAGRAM | http://instagram.com/thenrf1  EMAIL | nrf1podcast@gmail.com *** As for some of our most iconic podcasts, try these: e200 Our big anniversary! - https://audioboom.com/posts/6336063 e146 Jake Humphrey sorts F1 by shouting from his kitchen - https://audioboom.com/posts/5736293 e169 I still think I've got something special; the Stuart Webber interview - https://audioboom.com/posts/5971694 e184 Our British GP review recorded live on the Silverstone grid - https://audioboom.com/posts/6098909 e199 Vettel fails and that's probably that - https://audioboom.com/posts/6315458 @F1 #F1 #Formula1 #Podcast #Hamilton #Verstappen #SeasonReview #AbuDhabiGP #SaudiArabianGP  #BringBackCyril   #SummerBreak #BritishGP AustriaGP #StyriaGP #McLaren #Norris #RedBullRing #RedBull #Perez #2021  #FranceGP #MonacoGP #Review     #F1isback #Preview  #Albon #Schumacher #Ilott #WorldChampion  #Sebastian #Vettel #Charles #Leclerc #Valtteri #Bottas #Lewis #blacklivesmatter #Seb #Max #2019 #Kimi #Raikkkonen #Review #GrandPrix #GP #LH44 #TeamLH #SV5 #Podcast #Motorsport #F1Fantasy #F1FastFact #FIA #Norfolk #RedBull # #RBR #Ferrari #Ricciardo #Williams #Mercedes #ToroRosso #STR #Sainz #Renault #McLaren #Sauber #Haas #Romain #Grosjean #Leclerc #Gasly #George #Russell #F1isback

Welcome to today's podcast sponsored by the Learning Lab @meridianhealthinstitute  with your @EverydayHealthHacker, Dr. Liza Leal with  @mikeherzing  please be sure to follow us on your favorite platform and send us comments on topics you would like to discuss.  As our nation prepares to return to the workplace we have read studies reporting over 67% of business leaders are suffering from mental health issues. If you are suffering from anxiety, depression, melancholy, insomnia, overwhelm, panic attacks, self-medication, alcohol, substance abuse to name a few that may be  keeping your motivation away. Persevere there are answers and help. Today we will discuss tools to help your mindset achieve your goals. The secret to motivation is beyond setting the goal, the secret is tools to remind your subconscious and Super-consciousnessness  that you must practice for clarity and inspiration.  Wake-up with mindfulness in mind- whose life are you going to make an impact on today? Let's discuss how we get rid of “stinkin-thinkin” by resetting our compass and doing a little brain surgery on our mental atttitude. Are you ready? Let's make it happen! Remember trying is lying so let's build our brain chemistry with the though one mind that we will make it happen together and we need our entire team to reach our goals. You need you to reach your individual goals so let's get started together. If you would like additional information We want to be your resource for information don't hesitate to reach out to us at info@everydayhealthhacker.com Subscribe, like and comment we look forward to your questions.  For the Doctor's Recommendations on Supplements: She recommends the following in 30 oz of ice tea:  1.       MCM exogenous ketones: favorite flavors dragonfruit and elderflower, lemon and orange https://mcmnutrition.com take only if you crave carbs add 1-2 scoops to your beverage 2.       Mix with 1 ampule durt black or gold https://drliza.livelabsnow.com 3.       1 -2 scoops Metamucil 4.       1 axio preferred flavors are raspberry caffeine free and dragon fruit with caffeine https://drliza.lifevantage.com or we use Revitalize from prefer the Rasberry flavor we use 1/3 to ½. The citrus seems stronger. https://www.modere.com/?referralCode=6954210  5.       C4 orange flavor 1 scoop it is considered a pre-workout drink     In tablet or capsule form   1.       NRF2 and NRF1 take as directed once a day  from https://drliza.lifevantage.com   2.       COQ10  1 a day from https://www.modere.com/?referralCode=6954210 3.       Vit D3 5000 IU 1 a day  (above website) 4.       B 12 5000-10000 mcg NOW brand  use through out the day we purchase this on iherb or amazon depending on prices.    For a comprehensive wellness program and your mental health, medical, dental  and executive coaching needs reach out to us at: www.MeridianHealthInstitute.com www.Everydayhealthhacker.com 4655 Sweetwater Blvd. Ste 500 Sugar Land, Texas 77479 281-265-6565

WELCOME to The WELLNESS FOURplay Podcast Episode 27: Nutrigenomics We KNOW that Knowledge is the "foreplay" to your Wellness, so we want to make sure you are equipped to be your OWN Super Hero in your wellness journey! Equipping you with the KNOWLEDGE you need to have the HEALTH you so desire!  1. WHAT IS NUTRIGENOMICS?  Nutrigenomics (nutrition + genomics) is the cutting-edge science that shows you how to create the best path for your health. Using plants and plant compounds to optimize the performance of your DNA. 2. HOW CAN NUTRIGENOMICS BENEFIT YOU? Utilizing the knowledge of Nutrigenomics, we can look beyond all the talk of nutrition fads and advertising that is everywhere. Nutrigenomics can give you a simplified roadmap of the specific nutrients and food that can influence our genes towards optimal health. 3. WHEN CHOOSING MY FOOD, WHAT SHOULD I BE AWARE OF? What benefits or problems can be associated with this food? GMO: Natural vs. modified i.e.: Virginia Tech splicing Rat genes in lettuce, Monsanto placing fish genes in tomatoes. Pesticides, Organic, Farm raised vs. wild caught, Caged vs. Free Range, Factory Farming vs. Pasture raised & grass fed cows and pigs, Home cooked vs. Fast food or preserved. 4. WHAT ARE EXAMPLES OF USING NUTRIGENOMICS? Certain genes can cause inflammation or help tame it. Food that turns off the inflammatory gene: onions, garlic, leeks, elderberries, capers, turmeric and radishes. Natural compounds that activate Nrf2, NRF1 and NAD pathways that reduce Oxidative Stress, increase Mitochondrial production and Sirtuin Activity (see Theories on Aging: Episodes 16, 17, 18) You are what you eat. Put some thought and research into it. Consider this... You get what you pay for... how good for you can the food be when it only costs $1? Equipping you with the KNOWLEDGE you need to have the HEALTH you so desire! #WellnessFourPlay​ #ProactiveWellness​ #Nutrigenomics​ #ThePowerOfFood​ #Science​ #TheBiohackingTeam​ #EmpoweredWellness​ #wellness​ DondeeAndMarci.com

WELCOME to The WELLNESS FOURplay Podcast Episode 19: Synergy We KNOW that Knowledge is the "foreplay" to your Wellness, so we want to make sure you are equipped to be your OWN Super Hero in your wellness journey! Equipping you with the KNOWLEDGE you need to have the HEALTH you so desire!  Each episode we ask FOUR questions relating to a specific health topic. Here they are: 1. WHAT IS SYNERGY? The combined effort of two or more things that results in a different outcome than if it had been done individually. 2. CAN SYNERGY WORK IN POSITIVE AND NEGATIVE WAYS? Positive Synergy: 2+2=5. For example, a safe and complete airline flight. Negative Synergy: 2+2=3 For example, a plane crash, due to human maintenance oversight. 3. HOW CAN YOU STACK POSITIVE BEHAVIORS TO CREATE SYNERGY IN YOUR WELLNESS? Stack the following positive behaviors to have a synergistic effect in your everyday life: Mindset, Sleep/Rest, Nutrition, Water, Exercise, Prayer/Meditation, Positive People (Tribe Vibe), Gratitude, Goals, Rewards, Contribution. Use tiny habits in each of the above areas to create your Daily Method of Operation. (DMO) Consistency is the key to your Synergistic results! 4. HOW CAN SYNERGY SLOW DOWN YOUR AGING?  1+1+1= 10. Activation of the Nrf2, NRF1 and NAD cellular pathways to your DNA individually is beneficial, but activating ALL THREE at the same time gives 1792% greater benefit in Sirtuin response, 69% greater benefit in Mitochondrial function and 1563% greater response in Antioxidant Enzymes! THAT'S A HUGE DEAL! We invite you to get activated with $10 off discount code for your first purchase! Contact us at DondeeAndMarci.com and comment “Episode 19 Code” in the Contact Us tab. Thank you for spending your time with us!  #WellnessFourPlay​ #ProactiveWellness​ #Synergy​ #DoYouFeelOld​ #Nrf2​ #NRF1​ #NAD​ #Energy​ #TheBiohackingTeam​ #EmpoweredWellness​ #wellness​ DondeeAndMarci.com

Welcome to The Wellness FOURplay Podcast! Episode 17: AGING Part 3 - The Mitochondrial Theory We KNOW that Knowledge is the "foreplay" to your Wellness, so we want to make sure you are equipped to optimize yours! Equipping you with the KNOWLEDGE you need to have the HEALTH you so desire!  Each episode we ask FOUR questions on a specific Wellness topic. Here they are... 1. WHAT ARE MITOCHONDRIA? Mitochondria are the “energy factory” of our cells. Several thousand mitochondria are in nearly every cell in the body. Their job is to process oxygen and convert substances from the foods we eat into energy, our metabolism. Mitochondria produce 90% of the energy our body needs to function. 2. WHAT DOES MITOCHONDRIA HAVE TO DO WITH AGING? Our mitochondria are literally powering everything in our bodies, from our heartbeat to our brain cells and unfortunately, our mitochondria decline over time or when stressed. Mitochondria deals with aging in two ways: 1) Receiving information from the nucleus on the energy needs of the cell, and 2) Producing the energy that the cells need to do their job. Can lead to several negative body functions and diseases. 3. WHAT DOES MITOCHONDRIAL DECLINE FEEL LIKE? Fatigue, Brain fog, Sluggishness, Lack of motivation, Delayed healing, Vision decline, Muscle weakness, Confusion, Hearing problems, Learning disabilities, Joint tension, Lack of mobility, Gut issues, Headaches, Difficulty breathing, and more! 4. WHAT CAN WE DO TO PREVENT THE DECLINE OF OR RESTORE OUR MITOCHONDRIA? Start a preventative approach as quickly as possible. Reduce Oxidative Stress. Fortify your cells with good nutrition. Good carbohydrates, fats and proteins. Trigger the NRF1 Pathway. Equipping you with the KNOWLEDGE you need to have the HEALTH you so desire! #WellnessFourPlay​ #ProactiveWellness​ #AgingPartTré​ #DoYouFeelOld​ #Mitochondria​ #Energy​ #CellPower​ #TheBiohackingTeam​ #EmpoweredWellness​ #wellness​ DondeeAndMarci.com

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.05.326363v1?rss=1 Authors: Shaofan, H., Yuancai, X., Lu, Q., Meng, W., Zhang, Y. Abstract: The membrane-bound transcription factor Nrf1 (i.e., encoded by Nfe2l1) is activated by sensing glucose deprivation, cholesterol excess, proteasomal inhibition and oxidative stress, and then mediates distinct signaling responses in order to maintain cellular homeostasis. Here, we found that Nrf1 stability and transactivity are enhanced by USP19, a tail-anchored ubiquitin-specific protease in the endoplasmic reticulum (ER). Further experiments revealed that USP19 directly interacts with Nrf1 in proximity to the ER and acts as a deubiquitinating enzyme to remove ubiquitin moieties from this protein and hence circumvent potential proteasomal degradation. Such USP19-mediated effect takes place only after Nrf1 is retrotranslocated by p97 out of ER membranes. Conversely, knockout of USP19 causes significant decreases in Nrf1 abundance and its active isoform entering the nucleus, resulting in down-regulation of its target proteasomal subunits. This led to a modest reduction of USP19-/-derived tumor growth in xenograft mice, when compared with wild-type controls. Altogether, these demonstrate that USP19 serves as a novel mechanistic modulator of Nrf1, but not Nrf2. In turn, our additional evidence has also unraveled that transcriptional expression of endogenous USP19 and its promoter-driven reporter genes is regulated by Nrf2, as well by Nrf1, at distinct layers within a complex hierarchical regulatory network. Copy rights belong to original authors. Visit the link for more info

Today I talk to Jody Keefe about Life Vantage Protandim® Dual Synergizer™ Protandim NRF1 & Nrf2 effectively reduce oxidative stress by providing antioxidants and increasing the production of antioxidant enzymes (Superoxide Dismutase and Catalase) which provide antioxidant defense.   Protandim Dual Synergizer is designed to provide antioxidant defense for the maintenance of good health with two powerful effective products wrapped in one incredible value. With Protandim Dual Synergizer, you get two formulas that work at the cellular level to help you live a healthier life. And you get it all at an incredible value. Protandim Dual Synergizer comes with a long list of benefits that can: Benefits Helps increase the production of antioxidant enzymes Superoxide Dismutase and Catalase Provides antioxidant defense for maintenance of good health Provides antioxidants that help fight free radicals Help to temporarily relieve symptoms of stress  Support cognitive function and reduce mental fatigue Source of antioxidants Help fight against the cell damage caused by free radicals Meet The Soul And Science By applying the study of nutrigenomics to identify natural antioxidants, phytonutrients, and naturally occurring coenzymes to activate the Nrf2 and NRF1 pathways and promote mitochondrial growth and function and promote cellular health, we've created a product that slows aging down while helping you feel your best. You can contact Jody here on FaceBook You can learn more about Life Vantage products  Canada  and Life Vantage products USA  D'Vine Wellness Living with Intention: Hormone Transformation A unique signature program to meet you personally as a hormonal woman facing many challenges! Wise Divine Women Podcast Unfiltered Truth for Christian Women about Health, Libido, Detox, Stress & Inflammation Have you had a chance to download this program yet? It is full of incredible recipes and jam-packed with insightful information about all things balancing hormones https://linktr.ee/danairvine #wisedivinewomen #bralessandflawless #podcastlife #livingwithintention #transformation #touchyoutattas #hormonehealth #10daybodyreset #detox #healthyhabits #microcirculation #foodasmedicine #healthychristianwoman #prayer #meditate #lifespurpose #health #christianhealthcoach #encouragingwomen #nourishyourbody #holisticnutrition #spiritmindbody #healthandwellness #inflammation #seqex #thermography #balancehormones #eatingpsychologycoach www.dvinewellness.ca --- Send in a voice message: https://anchor.fm/wisedivinewomen/message

In today’s episode, Ryanne Sullivan, shares her 20-year journey with IBD. Diagnosed with both Crohn’s Disease and Ulcerative Colitis, she’s learned to manage her symptoms and achieve remission through nutrition and lifestyle. At age 14, she started treatment with medications, like many others, using steroids and 6MP to try and control inflammation and symptoms. But, she often found the side effects of medications to be worse than the IBD itself.  Over the years, Ryanne has found stress to be a major trigger of her flare ups. Right out of high school she started working full time and living on her own, but the stress brought on yet another flare. Remicade helped to put her back into remission, however, it was short lived and soon after she was back to battling Crohn’s symptoms.  After the Remicade failed, her aunt introduced her to “The Maker’s Diet” by Jordan S. Rubin. It focused on bringing nutrition back to the basics of real food, grown in nutrient-dense soil and improving the microbiome. The book kicked off her journey to discovering how she could control inflammation from within. Since then, Ryanne has only had a few flare ups due to the stress from each of her three pregnancies and with the knowledge and experience she’s gained over the years (and continues to gain!), she was able to get right back into remission.  Ryanne focuses her diet around foods and supplements that help reduce inflammation, including plenty of fruits and vegetables and grass-fed meats. Her family eats the same and follows a healthy lifestyle with her, though she does try to let her kids be kids and enjoy the occasional bowl of ice cream and Goldfish crackers :) She’s learned to listen to her body and knows what the first signs of a flare up are for her, which gives her a chance to head off a full-blown flare up by sticking to the basics and giving her gut a chance to heal. Her go-to methods and supplements include intermittent fasting/gut rest, aloe vera capsules (or juice), Protandim® Nrf2 and Nrf1, prebiotics and probiotics, easy-to digest foods and soups, golden milk (made with almond milk, turmeric, black pepper, ginger, and cinnamon), and dandelion tea. As many of us with Crohn’s Disease and Ulcerative Colitis know, genetics play a role in IBD. Recently, Ryanne’s 8-year-old daughter was diagnosed with Crohn’s and they’re working together to help give her the same level of control and quality of health. Ryanne talks about what it was like to have open and honest conversations about taking a holistic route with her daughter’s pediatrician and gastroenterologist. While medications are not off the table, they are hoping to avoid them. Ryanne’s advice for other parents with children diagnosed with IBD: keep a food journal, learn everything you can about the disease, learn to talk to doctors openly, and  get involved in the community! To keep up with Ryanne and her IBD journey, follow her on Instagram at:https://www.instagram.com/ryanne_sullivan/  

Johanna gave me some NRF1, NRF2 and NAD from the bio hacking company she works for. We are going to run a week long trial to see what the results are like on my energy, recovery and overall health and wellness. I am going to stop taking everything else I take [ie. Ginseng and Lions Mane]. 

I put this podcast together after being asked about a better way to look at your health. Its very important information for me to share. Ive been trained in how to educate about Nrf2 activation and now we have Nrf1, a drink formula, a topical lotion and Nrf2 activation for the scalp! There are a lot of waysto activate your own Nrf2 pathway. --- Support this podcast: https://anchor.fm/talkingwithTheresa/support

Join Spanners and Trumpets as they welcome special guests Terry Saunders from For F1's Sake podcast and Callum Springall from the NRF1 podcast as they discuss the amazingly weird French Grand Prix See acast.com/privacy for privacy and opt-out information.

137b-- Welcome to " The Indy SportsCar Podcast! " Hosts @MissyLinkz & @LLNKZ Are Very Honored to have Perry @PedHD56 from the @theNRF1 podcast to discuss the craziness that happened on the streets of Baku for last weekends #F1 #AzerbaijanGP being reffered to as the best race of the Decade! Questions are answered and we learn that it is Possible to have the best pure racing seen in years along with the #1 worst thing you could ever see a driver do in anger During an #F1 race! Simply put! This was about the best show we have ever done! @PedHD56 & @MissyLinkz Equaled Radio Gold today! Her Co-Host was not only Proud but blown away by the Great and very well infiormed opinions and Questions Perry was very more then Excited to answer and talk about! To support Perry and his Co-Host Journalist/Host Micheal Bailey, follow and subscribe to The NRF1 Podcast "A Slice of F1 Opinion Straight out of Norfolk" by visiting www.NRF1.UK for all their Social Media Outlets! stream or Download their Show at Audioboom, Spreaker and many of the same places you can find #ISCP FYI:) show e174 they had @LLNKZ on to talk about the #AFS @AudibleFlagging System to answer and exsplain their questions and the Huge Passion we have to make it a very near future reality that every racer will be racing safer on track then ever before! *Tops Mr. Bailey! Follow all our social media outlets at www.TheIndySportsCarPodcast.com Stream or Download the show from iTunes, Stitcher Radio, The Podbean App and or Pod-Catcher app you favor to listen too! were also very proudly on demand at www.RedDragonsRadio.com ...Cheers!!    

Do you want beautiful, flawless, radiantly healthy skin? Want to stay healthy during cold season? Want to eat that bagel without your blood sugar spiking through the roof? Then it's time to think about zinc. Zinc is critical to every aspect of our biology, but the first things to go when we run low are our skin health, our immune system, and our glucose tolerance. Zinc, moreover, is critical to antioxidant defense, so should be considered broadly protective against all of the degenerative diseases that occur with aging. Wait, are you too young to care about aging? No problem. You at least want healthy skin, great sex, or a lean physique, so listen up. Zinc-rich foods are harder to come by then you'd think. Nutritional databases can be wildly inaccurate if you don't adjust for inhibitors of zinc absorption in natural foods. And zinc supplements can be valuable, but they're not a panacea. In fact, used wrongly, they can quickly induce a deficiency of copper and other minerals that are just as critical to your health.  The show notes can be found at chrismasterjohnphd.com/36. They contain recommendations for specific supplements. This episode is brought to you by Kettle and Fire Bone Broth. Use the link kettleandfire.com/chris to get $10 off your first order. This episode is also brought to you by US Wellness Meats. Head to grasslandbeef.com and enter "Chris" at checkout to get 15% off your order as long as the final price is over $75 and you order fewer than 40 pounds of meat. You can use "Chris" to get the same discount twice. In this episode, you'll find all of the following and more:  0:00:35 Cliff Notes; 11:40 The discovery of zinc deficiency on diets of whole wheat bread with small amounts of milk and potatoes, a quarter pound of clay, and no meat: dry skin, hypogonadism, lack of secondary sex characteristics, short stature, frequent infections; 17:25 The biochemical and physiological roles of zinc; 19:00 structural roles of zinc, with an emphasis on zinc finger motifs; interactions with vitamins A and D, thyroid hormone, adrenal hormones, and sex hormones 24:07 Catalytic roles of zinc, including the RNA polymerases that make it necessary for the production of every single thing in the body; 26:30 Interactions with vitamin A, from transport via retinol-binding protein (RBP) through activation by alcohol dehydrogenases to retinal and retinoic acid through creating vision via rhodopsin and regulating gene transcription via DNA-binding of the retinoic acid receptor; 29:20 Regulatory roles of zinc 32:25 Zinc and oxidative stress (necessity for hydrogen peroxide production in the thyroid gland and immune phagocytes, zinc release from zinc-thiolate clusters; protective effects of metallothionein exchanging zinc for other metals; negative effects of uncoupling of endothelial nitric oxide synthase [eNOS] on blood vessel function and oxidative stress; 42:45 Regulation at the cellular level (metallothionein, MT; ZIP and ZnT transporters) 44:20 Regulation of metallothionein (metal transcription factor-1 [MTF-1] through the metal response element [MRE] controlled primarily by zinc but also heavy metals, antioxidant response element [ARE] via Nrf1 and Nrf2, which provides regulation by oxidative stress and copper, glucocorticoid response element [GRE] which provides regulation by adrenal hormones and inflammation; 53:40 What happens when we eat zinc (effects of phyate, amino acids, calcium, organic acids, and iron) 1:01:00 Plasma zinc and the exchangeable zinc pool 1:06:00 Factors that affect plasma zinc status (variation according to meals, diurnal variation, stress, inflammation, menstruation) 1:10:25 Causes and effects of deficiency 1:14:20 Variations in soil zinc; 1:15:40 Balance of animal protein and phytate in the diet 1:19:00 Causes and effects of toxicity (especially with respect to copper deficiency) 1:27:20 What is the best marker of zinc status? 1:29:45 Plasma zinc as a marker of zinc nutritional status; 1:37:00 Copper deficiency markers as the most sensitive markers of zinc excess 1:38:10 Dietary strategies (animal foods, especially oysters, red meat, and cheese; soaking, sprouting, and fermenting to neutralize phytate) 1:40:35 Zinc supplementation on a plant-based diet (especially relevant to vegan diets but also to vegetarian diets) 1:42:25 Supplementation of zinc (what form? Citrate, acetate, gluconate, picolinate, oxide? What dose? When to take it?) 1:44:35  Recommendations for timing of diet and supplements across the day for best absorption 1:47:00 Wrapping up

It's a bonus pod! To help while away the raceless weeks of the close season, have a special compilation (podpilation?) of some best bits from Norfolk's Formula One podcast over the course of the 2016 season. From bleeps to bloopers, sharp opinions, dodgy predictions and terrible singing, it's all here - and hopefully whets the appetite as NRF1's 2017 F1 season starts to appear on the horizon. Like what we do? Help us spread the word: www.patreon.com/nrf1 #F1 #theNRF1 #Formula1 #FormulaOne #2016 # motorsport Visit: www.nrf1.uk or email us: nrf1podcast@gmail.com Take up our offer - visit www.cornerstone.co.uk/nrf1

Here it is - the start of an epic finale to the 2016 Formula One season from Norfolk's F1 Podcast crew. The first of the NRF1's three-parts season review sees a podcast full house discuss Nico Rosberg's shock retirement, who will get that Mercedes Christmas present and where exactly the 2016 season will rank once history has its say. #F1 #theNRF1 #Formula1 #FormulaOne #2016 #motorsport www.nrf1.uk www.twitter.com/thenrf1 www.fb.me/thenrf1

It's here! It's crunch time for the 2016 world title, and the NRF1 prediction league too... Norfolk's Formula One crew preview the final race of the year, make their predictions, say goodbye to Jenson Button and wrap up all the latest F1 news. #f1 #theNRF1 #Formula1 #FormulaOne #AbuDhabiGP #2016 www.nrf1.uk Twitter & Facebook @thenrf1

What have we just seen?! Max Verstappen underlines his talent again. Sebastian Vettel complains again. Felipe Massa suffers Interlagos heartreak again. Then Sauber hit Manor hard - and there was even some important stuff at the front end of the championship fight. It was an epic Formula One weekend - hence an epic Norfolk F1 Podcast from the NRF1 crew. Enjoy, and share your views @theNRF1 on Twitter and Facebook or email NRF1podcast@gmail.com #F1 www.f1.com www.nrf1.uk #BrazilGP www.twitter.com/theNRF1 www.fb.me/theNRF1

Michael Bailey and his fellow Formula One enthusiasts dissect an epic race around the streets of Monte Carlo, hand out their Of The Weekend awards and tuck into some Jaffa Cakes. Don't forget to visit www.nrf1.uk, tweet @theNRF1 or pop on to www.facebook.com/NRf1podcast - plus you can now help the crew to spread the NRF1 word, at www.patreon.com/NRF1 'y2q2pgw2' Feeding BritCaster.com Your SEO optimized title page contents

Michael Bailey and this week's Norfolk Formula One Podcast crew of Kyle Cumbers, Richard Baxter and Steve Rust look back on a superb Chinese Grand Prix, pick their driver, team and Pastor of the weekend, as well as stopping off at the NRF1 pit stops. Join the conversation on Twitter @theNRF1, at facebook.com/NRF1podcast or email NRF1podcast@gmail.com

Michael Bailey and his Norfolk Formula One Podcast colleagues - Stephen Rust, Richard Baxter and Kyle Cumbers - sift through all the F1 news, look ahead to the forthcoming Singapore Grand Prix and make their predictions for what lies in store. You can get in touch too via Twitter @theNRF1, with an email to NRF1podcast@gmail.com or visit the website: www.NRF1.uk

Michael Bailey and his Norfolk Formula One Podcast colleagues Stephen Rust, Kyle Cumbers and Richard Baxter catch up with all the F1 action and news since the summer break. Get in touch with the crew via Twitter @theNRF1, with an email to NRF1podcast@gmail.com or via the website: www.NRF1.uk

In a bumper pod, Michael Bailey and Norfolk Formula One Podcast colleagues Kyle Cumbers, Richard Baxter and Stephen Rust get together to discuss a controversial Monaco Grand Prix, as well as looking ahead to this season's Canadian Grand Prix in Montreal - the panel also pin their colours to the NRF1 mast with their predictions.

A new season, a new name, a new podcast! The 2015 Formula One world championship is up and running, and the NRF1 Podcast will be following suit very shortly. Here's all the information you need, on the new face of the EDPF1 Podcast...