Podcasts about Visual system

Body parts responsible for sight

  • 53PODCASTS
  • 74EPISODES
  • 47mAVG DURATION
  • ?INFREQUENT EPISODES
  • May 30, 2025LATEST
Visual system

POPULARITY

20172018201920202021202220232024


Best podcasts about Visual system

Latest podcast episodes about Visual system

The Future of Everything presented by Stanford Engineering

Jason Yeatman is an expert in the neurobiology of literacy whose lab is fostering a virtuous research cycle between academia and school communities, aligning scientific inquiry with real-world needs of students, parents, and educators. His lab has developed ROAR – the Rapid Online Assessment of Reading—a gamified, web-based dyslexia screening tool. ROAR provides fast, precise, and scalable assessments, helping educators identify and get support to struggling students. We're aligning cutting-edge reading science with the challenges teachers face every day, Yeatman tells host Russ Altman on this episode of Stanford Engineering's The Future of Everything podcast.Listen to the end to hear a question from one of our listeners for Professor Renee Zhao, as well as Professor Zhao's response. Have a question for Russ? Send it our way in writing or via voice memo, and it might be featured on an upcoming episode. Please introduce yourself, let us know where you're listening from, and share your question. You can send questions to thefutureofeverything@stanford.edu.Episode Reference Links:Stanford Profile: Jason YeatmanRapid Online Assessment of Reading (ROAR)Jason and his team just launched ROAR@Home BETA, a parent research portal. Any parent who listens can sign up for ROAR here - https://roar.stanford.edu/signup/Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>> Twitter/X / Instagram / LinkedIn / FacebookChapters:(00:00:00) IntroductionRuss Altman introduces Jason Yeatman, a professor of pediatrics education and psychology at Stanford University.(00:03:12) Why Reading?Why Jason dedicated his career to studying reading acquisition.(00:04:12) Are We Built to Read?How reading is a relatively new invention using older brain systems.(00:06:41) Reading as a ContinuumWhether reading ability is distributed like other genetic human traits.(00:07:53) Defining DyslexiaReframing dyslexia as a label for support, not a binary diagnosis.(00:10:19) Phonological AwarenessUnderstanding how speech sound recognition underpins reading.(00:13:37) Nature vs. NurtureThe influence of both genetics and environment in reading ability.(00:16:40) The Origin of ROARAn online reading assessment tool created during the pandemic.(00:19:06) ROAR's EffectivenessThe accuracy in which ROAR can assess reading capability.(00:22:45) Reading Interventions That WorkExpanding support with evidence-based interventions for all ages.(00:25:25) Personalized DiagnosesTailoring interventions based on detailed individual skill diagnostics.(00:26:36) Scaling ROARScaling ROAR via an academic research-practice partnership model.(00:29:34) Infrastructure Behind ROARThe team and technology required to scale ROAR in schools.(00:31:54) Future of Reading AssessmentExpanding ROAR to include other dimensions of reading development.(00:33:44) Reading Across LanguagesWhy English poses more reading difficulties than many languages.(00:35:34) Listener Q&ANew segment answering audience questions from past episodes.(00:37:46) Conclusion Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook

Naked Neuroscience, from the Naked Scientists
Fruit fly vision, sensing sarcasm, and social connection

Naked Neuroscience, from the Naked Scientists

Play Episode Listen Later Jul 17, 2024 24:18


In the latest Naked Neuroscience, James Tytko brings you two new pieces of research involving the use of AI. First, how machine learning has been deployed to map out the visual system of a fruit fly in all its complexity, and how feeding a neural network a diet of quips from popular TV shows has produced the most effective sarcasm detector yet. Plus, David Robson outlines the strategies that will ensure you maintain strong social bonds, the topic of his latest book, 'The Laws of Connection.' Like this podcast? Please help us by supporting the Naked Scientists

Mind & Matter
Visual System, Visual Impairments & Cures, Amblyopia, Neuroplasticity, Critical Periods & Metaplasticity, Ketamine & Psychedelics | Mark Bear | #150

Mind & Matter

Play Episode Listen Later Apr 3, 2024 76:10


About the guest: Mark Bear, PhD is a Professor of Neuroscience at MIT, where his lab studies the visual system, neuroplasticity, and the pathophysiology of amblyopia and visual impairments.Episode summary: Nick and Dr. Bear discuss: the visual system in the brain, from the retina to visual cortex; critical periods of brain development; mechanisms of neuroplasticity; metaplasticity; amblyopia and visual impairments; ketamine & psychedelics; and more.*This content is never meant to serve as medical advice.Support the showAll episodes (audio & video), show notes, transcripts, and more at the M&M Substack Try Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase.Try SiPhox Health—Affordable, at-home bloodwork w/ a comprehensive set of key health marker. Use code TRIKOMES for a 10% discount.Try the Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for $50 off.Learn all the ways you can support my efforts

The KRUSE ELITE Podcast
The Neural Hierarchy Pt 1: The Visual System

The KRUSE ELITE Podcast

Play Episode Listen Later Mar 9, 2024 59:00


The neural hierarchy is a powerful explanatory framework for how our brain relies on sensory information when we are active, but what if the vast majority of the movement and fitness industry only focuses on the least important sensory system? Today, I speak with my podcast producer, Tony, about the neural hierarchy. I outline what the three sensory systems in the neural hierarchy are and focus on the visual system which accounts for 70% of the sensory information that our brain receives. I discuss my own challenges with visual impairment as a young athlete, how the visual system interacts with movement and athletic performance, and why a visual deficit can potentially lead to pain and injury. I also discuss how training and activating the visual system can have surprising benefits in pain management, threat reduction, and strength and coordination. Thank you to my podcast idea man and coach, Tony Fowler (Instagram: @tone_reverie) for helping me put together this episode! Whenever you're ready here's how we can help you: Follow structured programs to keep your joints healthy and your muscles strong even as you age by joining the Strength & Mobility Dojo

Child Care Bar And Grill
CCBAG_1100 The 8 Sensory Systems Part 5–Visual System

Child Care Bar And Grill

Play Episode Listen Later Mar 4, 2024 31:57


Nicole and Jeff are back with part 5 of their sensory system series. Thanks for listening! Links Visit Playvolution HQ Join Jeff for a CCBAG Happy Hour Check out Play Haven Share text and audio comments, or just come hang out at Play Haven Visit playvolutionhq.com/ccbag for cohost links, show archives, and more

Brain in a Vat
Facial Distortions and Prosopometamorphopsia | Brad Duchaine

Brain in a Vat

Play Episode Listen Later Mar 3, 2024 61:22


In this special episode of Brain in a Vat, Brad Duchaine from the Psychological and Brain Sciences Department at Dartmouth discusses prosopometamorphopsia (PMO) – a condition where individuals see distorted faces. The episode explores various manifestations of PMO, including seeing demonic features, dragons, or entirely different faces, and distinguishes it from prosopagnosia (face blindness). It delves into the neurological basis of PMO, touching upon structural and functional differences in the brains of those affected. We discuss the significant impact PMO and prosopagnosia have on individuals' social interactions and quality of life, as well as potential management techniques such as using glasses or colored lights to reduce distortions.   00:00 Introduction and Guest Presentation 00:20 Exploring the Case of Face Distortion 03:19 Understanding the Nature of Distortions 05:49 Comparing Prosopagnosia and PMO 07:17 The Role of Visual System in Face Recognition 10:01 Impact of Face Recognition on Social Interactions 14:16 The Spectrum of Face Recognition Abilities 16:20 The Role of AI and Hallucinations in Face Recognition 23:48 Understanding the Diagnosis of Face Recognition Disorders 30:20 Understanding Prosopagnosia: Prevalence and Characteristics 31:59 The Mystery of PMO: Prevalence and Need for More Research 32:46 Exploring the Impact of Prosopagnosia and PMO on Social and Sexual Relationships 33:23 The Intersection of PMO and Other Psychiatric Conditions 37:03 The Struggles and Challenges of Living with Prosopagnosia and PMO 41:02 Potential Treatments and Coping Mechanisms for PMO 51:22 The Neurological Basis of PMO and Prosopagnosia 54:51 Testing and Characterizing PMO: A Deep Dive into Research Methods 59:54 Understanding the Perception and Processing of Faces in PMO

Anthro Education
Visual System Finding in Basketball Player with Back Pain; High School Runner with Bilateral Hamstring Pain; Elite Gymnast/Crossfitter with Neck Pain: Week in Review 24

Anthro Education

Play Episode Listen Later Jan 14, 2024 75:08


Join the FARM crew on this week's episode of the Week in Review to discuss some interesting cases involving the visual systems presentation in low back and ankle pain, how bilateral hamstring pain was masked as a central sensitization case, and how a high-level gymnast still needs to work on scapulothoracic stability.

Huberman Lab
Mark Zuckerberg & Dr. Priscilla Chan: Curing All Human Diseases & the Future of Health & Technology

Huberman Lab

Play Episode Listen Later Oct 23, 2023 135:31


In this episode, my guests are Mark Zuckerberg, CEO of Meta (formerly Facebook, Inc.), and his wife, Dr. Priscilla Chan, M.D., co-founder and co-CEO of the Chan Zuckerberg Initiative (CZI). We discuss how CZI plans to cure all human diseases by the end of this century by funding transformative projects and technologies at the intersection of biology, engineering, and artificial intelligence (AI). They describe their funding and development of CZI Biohubs and the progress already underway to accelerate the understanding of cell function, pathways, and disease. Then, Mark discusses social media, its impact on mental health, and new tools for online experiences. We also discuss Meta's virtual reality (VR), augmented and mixed reality tech, and how AI will soon completely transform our online and physical life experiences. This episode ought to interest anyone curious about biology, medicine, mental health, AI, and the future of technology and humanity. For the full show notes, including the episode transcript (available exclusively to Huberman Lab Premium members), please visit hubermanlab.com. Pre-sale password: HUBERMAN Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman LMNT: https://drinklmnt.com/huberman InsideTracker: https://insidetracker.com/huberman Momentous: https://livemomentous.com/huberman The Brain Body Contract Tickets: https://www.hubermanlab.com/events Timestamps (00:00:00) Mark Zuckerberg & Dr. Priscilla Chan (00:02:15) Sponsors: Eight Sleep & LMNT; The Brain Body Contract (00:05:35) Chan Zuckerberg Initiative (CZI) & Human Disease Research (00:08:51) Innovation & Discovery, Science & Engineering (00:12:53) Funding, Building Tools & Imaging (00:17:57) Healthy vs. Diseased Cells, Human Cell Atlas & AI, Virtual Cells (00:21:59) Single Cell Methods & Disease; CELLxGENE Tool  (00:28:22) Sponsor: AG1 (00:29:53) AI & Hypothesis Generation; Long-term Projects & Collaboration (00:35:14) Large Language Models (LLMs), In Silico Experiments (00:42:11) CZI Biohubs, Chicago, New York (00:50:52) Universities & Biohubs; Therapeutics & Rare Diseases (00:57:23) Optimism; Children & Families (01:06:21) Sponsor: InsideTracker (01:07:25) Technology & Health, Positive & Negative Interactions (01:13:17) Algorithms, Clickbait News, Individual Experience (01:19:17) Parental Controls, Meta Social Media Tools & Tailoring Experience (01:24:51) Time, Usage & Technology, Parental Tools (01:28:55) Virtual Reality (VR), Mixed Reality Experiences & Smart Glasses (01:36:09) Physical Exercise & Virtual Product Development (01:44:19) Virtual Futures for Creativity & Social Interactions (01:49:31) Ray-Ban Meta Smart Glasses: Potential, Privacy & Risks (02:00:20) Visual System & Smart Glasses, Augmented Reality (02:06:42) AI Assistants & Creators, Identity Protection (02:13:26) Zero-Cost Support, Spotify & Apple Reviews, Sponsors, YouTube Feedback, Momentous, Social Media, Neural Network Newsletter Title Card Photo Credit: Mike Blabac Disclaimer

The Gestalt Education Show
In The Trenches: Jachym Kolar, MPT | Visual System's Role In Movement

The Gestalt Education Show

Play Episode Listen Later Oct 18, 2023 42:16


Today's episode features another fantastic Prague School therapist. Jachym Kolar's passion lies in the visual system. He believes the visual system can have a huge influence on the quality of movement patterns in our patients. This can be for the better or worse. We dive into assessment and treatment of the visual system and Jachym tells some great Prague stories. Enjoy! Show Notes Neurodynamics World Congress Upcoming Courses Human Locomotion.com | Code 'GESTALTEDUCATION10' Core360 Belt | Code 'GESTALT' Dynamic Disc Designs | Code 'GESTALT' --- Support this podcast: https://podcasters.spotify.com/pod/show/gestalt-education/support

PaperPlayer biorxiv neuroscience
The unique properties of Big tau in the visual system

PaperPlayer biorxiv neuroscience

Play Episode Listen Later Jul 12, 2023


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.11.548562v1?rss=1 Authors: Fischer, I., Connors, T., Bouyer, J., Jin, Y. Abstract: Tau is a microtubule associated protein that plays important roles in regulating the properties of microtubules and axonal transport, as well as tauopathies associated with toxic aggregates leading to neurodegenerative diseases. It is encoded by the MAPT gene forming multiple isoforms by alternative splicing of exons 2/3 at the N-terminal and exon 10 which determines the numbers of microtubule binding repeats (3R or 4R). The high molecular weight (MW) tau isoform termed Big tau contains an additional large exon 4a generating a long projecting domain and expressed as a 110 kDa protein. Big tau was originally discovered in the peripheral nervous system but later found in selective CNS areas that project to the periphery as well as in the cerebellum and the visual system. However, there is a gap of knowledge in understanding the expression patterns and the role of Big tau during normal neuronal development and pathological conditions relative to the common low MW isoforms. Here we investigated the properties of Big tau in the retina and optic nerve and in particular its unique isoform structure as a middle MW of 90kDa and its distribution in retinal ganglion cells and axons of the optic nerve. We discovered that Big tau expresses the 4a exon as well as exon 6, lacking exons 2/3 but sharing the extensive phosphorylation characteristic of other tau isoforms. Importantly, the visual system expresses both the low and middle MW isoforms in adult retinal ganglion neurons and their corresponding axons. This is a unique structure and expression pattern of Big tau likely associated with different properties than what has been previously described, requiring more research to elucidate the detailed roles of Big tau in the visual system. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

PaperPlayer biorxiv neuroscience
Factorized visual representations in the primate visual system and deep neural networks

PaperPlayer biorxiv neuroscience

Play Episode Listen Later Apr 22, 2023


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.22.537916v1?rss=1 Authors: Lindsey, J. W., Issa, E. B. Abstract: Object classification has been proposed as a principal objective of the primate ventral visual stream. However, optimizing for object classification alone does not constrain how other variables may be encoded in high-level visual representations. Here, we studied how the latent sources of variation in a visual scene are encoded within high-dimensional population codes in primate visual cortex and in deep neural networks (DNNs). In particular, we focused on the degree to which different sources of variation are represented in non-overlapping ("factorized") subspaces of population activity. In the monkey ventral visual hierarchy, we found that factorization of object pose and background information from object identity increased in higher-level regions. To test the importance of factorization in computational models of the brain, we then conducted a detailed large-scale analysis of factorization of individual scene parameters -- lighting, background, camera viewpoint, and object pose -- in a diverse library of DNN models of the visual system. Models which best matched neural, fMRI and behavioral data from both monkeys and humans across 12 datasets tended to be those which factorized scene parameters most strongly. In contrast, invariance to object pose and camera viewpoint in models was negatively associated with a match to neural and behavioral data. Intriguingly, we found that factorization was similar in magnitude and complementary to classification performance as an indicator of the most brainlike models suggesting a new principle. Thus, we propose that factorization of visual scene information is a widely used strategy in brains and DNN models. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

PaperPlayer biorxiv neuroscience
Complex Formation of Immunoglobulin Superfamily Molecules Side-IV and Beat-IIb Regulates Synaptic Specificity in the Drosophila Visual System

PaperPlayer biorxiv neuroscience

Play Episode Listen Later Mar 28, 2023


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.27.534487v1?rss=1 Authors: Osaka, J., Ishii, A., Wang, X., Hakeda-Suzuki, S., Iwanaga, R., Kawamura, H., Suzuki, T. Abstract: Neurons express many cell surface proteins as mutually binding key-lock molecules that can create synapses. However, the molecular mechanisms of how neurons make synapses only with preferred targets are not completely understood. Here we identified Side-IV and Beat-IIb, belonging to the Drosophila immunoglobulin superfamily, as a new key-lock combination capable of inducing synapse formation. Side-IV interaction with Beat-IIb transduces bifurcated signaling to Side-IV's co-receptor, Kirre, and a synaptic scaffold protein, Dsyd-1. Localization and genetic interaction analyses revealed that Side-IV localizes subcellularly at synapse formations defined by Beat-IIa/b and anchors Dsyd-1.Our data demonstrate that a complex made up of Side-IV, Beat-IIb, Kirre, and Dsyd-1 not only narrows neuronal binding specificity but also recruits synapse formation factors Kirre and Dsyd-1 to restrict synapse formation loci and inhibit miswiring. We propose a mechanism by which key-lock molecules set a hierarchy of preference among neuronal pairs in a complex circuit in vivo. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

KONCRETE Podcast
#173 - How to Improve Intelligence, Thinking, & Perception Through the Visual System | Dr. David Cook

KONCRETE Podcast

Play Episode Listen Later Feb 14, 2023 143:46


Over the span of his 40 plus-year career, Dr. David Cook's focus has been on testing, monitoring, and fine-tuning vision therapy as a clinician, author and educator. As one of the nation's leading authorities on vision therapy, Dr. Cook has given lectures on expanding depth perception to optometrists and other eye professionals at clinical seminars, study groups and optometric congresses all over the world. His book “The Shape of the Sky” teaches us that vision is something we do, and more importantly, something we can learn to do better." EPISODE LINKS: https://www.oepf.org/product/the-shape-of-the-sky https://CookVisionTherapy.com JOIN OUR KULT: https://bit.ly/koncretepatreon DANNY https://www.instagram.com/jonesdanny https://twitter.com/jonesdanny OUTLINE 0:00 - Introduction 4:02 - What is Vision? 5:05 - Neuroplasticity 7:50 - Using vision to improve Intelligence 13:44 - Dyslexia 22:51 - Technology is making the world ‘near-sighted' 37:47 - Binocular vision 46:17 - 3D vision in super athletes 1:03:14 - Vision & personality 1:12:56 - Knowledge by experience VS acquaintance 1:20:08 - Eye games 1:33:05 - Protocols to improve reading skills 1:41:50 - How language changes perception 1:48:07 - Picasso & Rembrandt were stereo blind 1:55:59 - Color blindness 2:00:45 - Daily protocols to enhance small vision (Deep Winks) 2:05:16 - Daily protocols to enhance big vision (3D) 2:16:06 - The shape of the sky 2:20:39 - How seeing changes thinking

PaperPlayer biorxiv neuroscience
Curvature coding in early visual system revealed by scale invariance during adaptation to flashing circles

PaperPlayer biorxiv neuroscience

Play Episode Listen Later Feb 12, 2023


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.11.528121v1?rss=1 Authors: Nisar, I. Abstract: How is curvature coded in the early human visual system? This question is the essence of basic shape recognition and may explain why humans are so successful in recognizing objects under difficult and varying environment conditions. We use the circle-polygon illusion ~cite{Khuu2002}, to reveal coding mechanisms in the early visual system. The stimulus, constructed by Sakurai's method ~cite{Sakurai2014}, is a static dark outline circle augmented with a 2 Hz pulsed luminance gradient around the inner border. Both the radius and eccentricity of the stimulus were varied in a crossed design over 1-8 deg. Observers reported a circle or the polygon order and the strength of the percept. We test a lower level account that argues for curvature opponency between neurons against a higher level account that codes for whole shapes. This higher level account supports scale invariance, a property through which we recognize objects regardless of the object's rotation (or orientation) and its size on the retina. We show the following: (1) Scale invariance, a property of the higher level visual system feature through which we recognize objects regardless of the object's rotation (or orientation) and its size on the retina, is not obeyed during adaptation. The mean order of the perceived polygon increased with stimulus size and decreased with eccentricity. It did not remain constant for a stimulus size. This demonstrates that the curvature coding occurs in the early visual system. (2) Linear regression analysis reveals that the cortical size of the stimulus is a better predictor of perceived polygon order. We computed the circumference of each stimulus in both retinal and cortical coordinates, taking cortical magnification into account. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

PaperPlayer biorxiv neuroscience
Neural tuning instantiates prior expectations in the human visual system

PaperPlayer biorxiv neuroscience

Play Episode Listen Later Jan 27, 2023


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.26.525790v1?rss=1 Authors: Harrison, W., Bays, P., Rideaux, R. Abstract: Perception is often modelled as a process of active inference, whereby prior expectations are combined with noisy sensory measurements to estimate the structure of the world. This mathematical framework has proven critical to understanding perception, cognition, motor control, and social interaction. While theoretical work has shown how priors can be computed from environmental statistics, their neural instantiation could be realised through multiple competing encoding schemes. Using a data-driven approach, here we extract the brain's representation of visual orientation and compare this with simulations from different sensory coding schemes. We found that the tuning of the human visual system is highly conditional on stimulus-specific variations in a way that is not predicted by previous proposals. We further show that the adopted encoding scheme effectively embeds an environmental prior for natural image statistics within the sensory measurement, providing the functional architecture necessary for optimal inference in the earliest stages of cortical processing. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

PaperPlayer biorxiv neuroscience
Category-induced global effects of feature-based attention in human visual system

PaperPlayer biorxiv neuroscience

Play Episode Listen Later Dec 22, 2022


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.21.521513v1?rss=1 Authors: Huang, L., Wang, J., He, Q., Li, C., Sun, Y., Seger, C. A., ZHANG, X. Abstract: Global effects of FBA are generally limited to stimuli sharing the same or similar features, as hypothesized in the "feature-similarity gain model". Visual perception, however, often reflects categories acquired via experience; whether the global-FBA effect can be induced by the categorized features remains unclear. Here human subjects were trained to classify motion-directions into two discrete categories and performed a classical motion-based attention task. We found a category-induced global-FBA effect in both the MT+ and frontoparietal areas, where attention to a motion-direction globally spread to unattended motion-directions within the same category, but not to those in a different category. Effective connectivity analysis showed that the category-induced global-FBA effect in MT+ was derived by feedback from the IFJ. Altogether, our results reveal for the first time a category-induced global-FBA effect and identify a source for this effect in human prefrontal cortex, implying that FBA is of greater ecological significance than previously thought. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Rewiring Health
Ep. 21 How to significantly drop your stress levels through your visual system

Rewiring Health

Play Episode Listen Later Dec 19, 2022 12:04


Why staring at your phone is increasing your stress levels and how you can promote relaxation in your life. Like this episode? Don't forget to subscribe to my channel for the latest episodes and leave a review. Your comments help spread this podcast to help others in their journey. Follow me on IG and Facebook @drkellykessler Grab my free Breathwork Guide, Sleep Checklist, and Daily Habits Checklist! https://linktr.ee/KellyKessler --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/rewiringhealth/support

A Sherpa's Guide to Innovation
E114: Bob Moesta - Learning to Build Through 847 Notebooks

A Sherpa's Guide to Innovation

Play Episode Listen Later Nov 23, 2022 54:16


Ben and Jay welcome back the one and only Bob Moesta for a record 4th episode.  Bob is a founding father of Jobs to Be Done theory, CEO of The ReWired Group (which has a great new website) and author of the recently published Learning to Build: 5 Bedrock Skills of Innovators and Entrepreneurs.  Hear Bob talk about why he wrote the book, a couple of non-JTBD topics from the book, and what he's focusing on in his remaining 1,890 days.  Yes, it's morbid, but it will be explained.  And hopefully it's much longer than that.Learn about another of Bob's mentor's, David T. Lord here, and his book The Visual System of Work here.All Things Twitter, while it lasts:Bob MoestaA Sherpa's Guide to InnovationBen TingeyJay GerhartSupport the show

PaperPlayer biorxiv neuroscience
Synaptic and circuit mechanisms prevent detrimentally precise correlation in developing visual system

PaperPlayer biorxiv neuroscience

Play Episode Listen Later Nov 13, 2022


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.11.516093v1?rss=1 Authors: Tikidji-Hamburyan, R. A., Govindaiah, G., Guido, B., Colonnese, M. T. Abstract: During development, retinal axons create broad and imprecise connections in the thalamus. This topology, very different from adults, supplies developing thalamic neurons with locally homogeneous synaptic currents and should cause spike correlation between thalamocortical neurons on a millisecond timescale. Such correlations have not been observed in vivo, at these ages, and would likely be maladaptive. Here, we use a biophysical model of the visual thalamus with the membrane and synaptic properties of 7-10 day-old mice to show that the developmentally appropriate dominance of NMDA-receptor currents and absence of strong recurrent inhibitory and excitatory connections prevents precise correlation and preserves topographic information in thalamic spikes. We illustrate possible reasons for this desynchronization using a phenomenological cortical model, which shows impaired network diversity when driven with precisely correlated inputs. Our results suggest that developing synapses and circuits evolved mechanisms to compensate for detrimental, "parasitic" correlation arising from the unrefined and immature circuit. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

PaperPlayer biorxiv neuroscience
A computational framework linking synaptic adaptation to circuit behaviors in the early visual system

PaperPlayer biorxiv neuroscience

Play Episode Listen Later Aug 29, 2022


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.08.27.505287v1?rss=1 Authors: He, L., He, Y., Lun, K., Ma, L., Du, K., Huang, T. Abstract: Retina ribbon synapses are the first synapses in the visual system. Unlike the conventional synapses in the central nervous system triggered by action potentials, ribbon synapses are uniquely driven by graded membrane potentials and are thought to transfer early sensory information faithfully. However, how ribbon synapses compress the visual signals and contribute to visual adaptation in retina circuits is less understood. To this end, we introduce a physiologically constrained module for the ribbon synapse, termed Ribbon Adaptive Block (RAB), and an extended "hierarchical Linear-Nonlinear-Synapse" (hLNS) framework for the retina circuit. Our models can elegantly reproduce a wide range of experimental recordings on synaptic and circuit-level adaptive behaviors across different cell types and species. In particular, it shows strong robustness to unseen stimulus protocols. Intriguingly, when using the hLNS framework to fit intra-cellular recordings from the retina circuit under stimuli similar to natural conditions, we revealed rich and diverse adaptive time constants of ribbon synapses. Furthermore, we predicted a frequency-sensitive gain-control strategy for the synapse between the photoreceptor and the CX bipolar cell, which differ from the classic contrast-based strategy in retina circuits. Overall, our framework provides a powerful analytical tool for exploring synaptic adaptation mechanisms in early sensory coding. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

Podcast Notes Playlist: Latest Episodes
Dr. Emily Balcetis: Tools for Setting & Achieving Goals | Episode 83

Podcast Notes Playlist: Latest Episodes

Play Episode Listen Later Aug 4, 2022 98:17


Huberman Lab Podcast Notes Key Takeaways How you visualize a goal or problem in your mind dictates how well you lean into that goal: whether you will be able to meet the goal, how you feel after, and your capacity to tackle larger goals“Proximity to a goal increases the investment and resources that people use to meet that goal.” – Dr. Emily BalcetisSet goals that are challenging but not impossible – and – not so easy that it's a no-brainer or requires minimal effortOverweight/deconditioned people see the world as more challenging: hills are steeper, finish lines are further – which shifts these people into a state of fatigue and makes it harder to start & overcomeTrouble finishing your run? Focus on intermediate targets along the way which makes the goal feel closer and you push harderVisualization/vision boards alone are not enough! To put visualizations into action: (1) set a plan – break it down into practical day-to-day; (2) think about obstacles that stand in the way of success so they don't surprise you along the wayWhen setting goals you can't tangibly see, don't count on your memory – write down progress along the way or use an app to help you more accurately track & reflect on progressRead the full notes @ podcastnotes.orgMy guest this episode is Dr. Emily Balcetis, PhD, Professor of Psychology at New York University (NYU). Dr. Balcetis' research focuses on how our perception of the world, particularly our visual perceptions, influences our level and persistence of motivation, how we conceptualize goals, actual goal achievement, and our emotional state as we pursue goals. Dr. Balcetis explains how to best visualize and overcome challenges in pursuit of larger, complex goals. We also discuss the science of how to define goals and intermediate milestones, overcome obstacles, and effectively track progress. This episode highlights science-based, immediately actionable tools that anyone can use to set and achieve physical and/or cognitive goals more effectively. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman  Thesis: https://takethesis.com/huberman Levels: https://levels.link/huberman ROKA: https://roka.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman For the full show notes, visit hubermanlab.com Timestamps (00:00:00) Dr. Emily Balcetis, Visualization of Goals & Motivation (00:03:24) Momentous Supplements (00:04:38) Thesis, Levels, ROKA (00:08:08) Vision & Motivation (00:11:37) Tool: Narrowing Visual Focus & Improving Exercise (00:21:39) Adjusting Visual Attention & Perceived Fatigue (00:25:14) Tool: Visual Focus “Spotlight” (00:27:57) Tool: Goal Gradient Hypothesis, Visual Spotlight to Increase Effort (00:33:38) AG1 (Athletic Greens) (00:35:00) Defining Goals vs. Accomplishing Goals, Dream Boards & Goal Lists  (00:41:28) Tool: How to Setting Better Goals & Identify Obstacles (00:46:38) Vision is Unique, Challenging the Visual System, Realistic Goals & Micro-Goals (00:57:12) Do Fit People View the World Differently?, States of Body & Visual Experiences (01:05:54) Caffeine, Stimulants, Visual Windows & Motivation (01:10:13) Tools: Goal Setting & Cognitive (Non-Physical) Goals, Data Collection (01:21:54) Year in Review & Memory (01:26:32) Visual Tools & Mental Health, Depression & Visual Priming (01:31:33) Focusing Attention & Increasing Visual Detail/Resolution (01:36:12) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Neural Network Newsletter, Instagram, Twitter, Momentous Supplements Title Card Photo Credit: Mike Blabac Disclaimer

Signal From The Noise: By Podcast Notes
Episode 83: Dr. Emily Balcetis – Tools For Setting & Achieving Goals | Huberman Lab

Signal From The Noise: By Podcast Notes

Play Episode Listen Later Aug 4, 2022


Huberman Lab: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- My guest this episode is Dr. Emily Balcetis, PhD, Professor of Psychology at New York University (NYU). Dr. Balcetis' research focuses on how our perception of the world, particularly our visual perceptions, influences our level and persistence of motivation, how we conceptualize goals, actual goal achievement, and our emotional state as we pursue goals. Dr. Balcetis explains how to best visualize and overcome challenges in pursuit of larger, complex goals. We also discuss the science of how to define goals and intermediate milestones, overcome obstacles, and effectively track progress. This episode highlights science-based, immediately actionable tools that anyone can use to set and achieve physical and/or cognitive goals more effectively. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman  Thesis: https://takethesis.com/huberman Levels: https://levels.link/huberman ROKA: https://roka.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman For the full show notes, visit hubermanlab.com Timestamps (00:00:00) Dr. Emily Balcetis, Visualization of Goals & Motivation (00:03:24) Momentous Supplements (00:04:38) Thesis, Levels, ROKA (00:08:08) Vision & Motivation (00:11:37) Tool: Narrowing Visual Focus & Improving Exercise (00:21:39) Adjusting Visual Attention & Perceived Fatigue (00:25:14) Tool: Visual Focus “Spotlight” (00:27:57) Tool: Goal Gradient Hypothesis, Visual Spotlight to Increase Effort (00:33:38) AG1 (Athletic Greens) (00:35:00) Defining Goals vs. Accomplishing Goals, Dream Boards & Goal Lists  (00:41:28) Tool: How to Setting Better Goals & Identify Obstacles (00:46:38) Vision is Unique, Challenging the Visual System, Realistic Goals & Micro-Goals (00:57:12) Do Fit People View the World Differently?, States of Body & Visual Experiences (01:05:54) Caffeine, Stimulants, Visual Windows & Motivation (01:10:13) Tools: Goal Setting & Cognitive (Non-Physical) Goals, Data Collection (01:21:54) Year in Review & Memory (01:26:32) Visual Tools & Mental Health, Depression & Visual Priming (01:31:33) Focusing Attention & Increasing Visual Detail/Resolution (01:36:12) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Neural Network Newsletter, Instagram, Twitter, Momentous Supplements Title Card Photo Credit: Mike Blabac Disclaimer

Huberman Lab
Dr. Emily Balcetis: Tools for Setting & Achieving Goals | Episode 83

Huberman Lab

Play Episode Listen Later Aug 1, 2022 98:17


My guest this episode is Dr. Emily Balcetis, PhD, Professor of Psychology at New York University (NYU). Dr. Balcetis' research focuses on how our perception of the world, particularly our visual perceptions, influences our level and persistence of motivation, how we conceptualize goals, actual goal achievement, and our emotional state as we pursue goals. Dr. Balcetis explains how to best visualize and overcome challenges in pursuit of larger, complex goals. We also discuss the science of how to define goals and intermediate milestones, overcome obstacles, and effectively track progress. This episode highlights science-based, immediately actionable tools that anyone can use to set and achieve physical and/or cognitive goals more effectively. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman  Thesis: https://takethesis.com/huberman Levels: https://levels.link/huberman ROKA: https://roka.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman For the full show notes, visit hubermanlab.com Timestamps (00:00:00) Dr. Emily Balcetis, Visualization of Goals & Motivation (00:03:24) Momentous Supplements (00:04:38) Thesis, Levels, ROKA (00:08:08) Vision & Motivation (00:11:37) Tool: Narrowing Visual Focus & Improving Exercise (00:21:39) Adjusting Visual Attention & Perceived Fatigue (00:25:14) Tool: Visual Focus “Spotlight” (00:27:57) Tool: Goal Gradient Hypothesis, Visual Spotlight to Increase Effort (00:33:38) AG1 (Athletic Greens) (00:35:00) Defining Goals vs. Accomplishing Goals, Dream Boards & Goal Lists  (00:41:28) Tool: How to Setting Better Goals & Identify Obstacles (00:46:38) Vision is Unique, Challenging the Visual System, Realistic Goals & Micro-Goals (00:57:12) Do Fit People View the World Differently?, States of Body & Visual Experiences (01:05:54) Caffeine, Stimulants, Visual Windows & Motivation (01:10:13) Tools: Goal Setting & Cognitive (Non-Physical) Goals, Data Collection (01:21:54) Year in Review & Memory (01:26:32) Visual Tools & Mental Health, Depression & Visual Priming (01:31:33) Focusing Attention & Increasing Visual Detail/Resolution (01:36:12) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Neural Network Newsletter, Instagram, Twitter, Momentous Supplements Title Card Photo Credit: Mike Blabac Disclaimer

AV Experts Podcast
How The Metaverse Will Impact Your Audio-visual System

AV Experts Podcast

Play Episode Listen Later Jan 24, 2022 12:10


On this episode of #avexpertspodcast I disect how the Metaverse will impact the way we interact with audio-visual technology. This episode is brought to you by Innoface Systems, Inc. www.innofacesystems.com Give Innoface Systems a call for all of your audio-visual needs 877-721-4040.

Ask the Naked Scientists Podcast
Is Google Maps harming my sense of direction?

Ask the Naked Scientists Podcast

Play Episode Listen Later Nov 20, 2021 28:01


This week, what's the bottom line on sanitising surfaces against Covid-19? Why, wonders Lester, am I so sluggish for the first few hours of the day? And can you train your chronotype to be a better morning person? Does it make a difference if you sleep on your left or your right? Why is gambling addictive and is addiction a genetic trait? Can pornography be addictive? And will resorting to apps like Google Maps impact my sense of direction? Join Dr Chris Smith and Lester Kiewit for the answers... Like this podcast? Please help us by supporting the Naked Scientists

Ask the Naked Scientists
Is Google Maps harming my sense of direction?

Ask the Naked Scientists

Play Episode Listen Later Nov 20, 2021 28:01


This week, what's the bottom line on sanitising surfaces against Covid-19? Why, wonders Lester, am I so sluggish for the first few hours of the day? And can you train your chronotype to be a better morning person? Does it make a difference if you sleep on your left or your right? Why is gambling addictive and is addiction a genetic trait? Can pornography be addictive? And will resorting to apps like Google Maps impact my sense of direction? Join Dr Chris Smith and Lester Kiewit for the answers... Like this podcast? Please help us by supporting the Naked Scientists

JNNP podcast
Alemtuzumab's impact on functional and structural integrity of the visual system in MS

JNNP podcast

Play Episode Listen Later Nov 17, 2021 20:02


Prof Michael Barnett, Director Sydney Neuroimaging Analysis Centre and Professor of Neurology, University of Sydney, joins JNNP's Podcast Editor, Colin Mahoney, to discuss how the use of Alemtuzumab may have longer-term impacts on improving one of the most commonly involved neurological pathways, the visual system, in multiple sclerosis (MS). Prof Barnett discusses his team's results after following up patients with highly active MS for 24 months, using multifocal visual evoked potentials and advanced neuroimaging. He also talks about what this means for future remyelination strategies. Related paper: https://jnnp.bmj.com/content/92/12/1319

The Headache Doctor Podcast
Our Visual System: Light Sensitivities (Part 2 of 2)

The Headache Doctor Podcast

Play Episode Listen Later Aug 9, 2021 18:33


Where do light sensitivities, or photophobias come from? You have photophobia if you are more sensitive to light coming in, and have an increase in migraine symptoms with light. Research shows 80% of migraine sufferers have this, it's a very common problem. We will discuss colors, colorblindness, and blue light blocking eye glasses.

The Headache Doctor Podcast
Our Visual System: Eye Strain (Part 1 of 2)

The Headache Doctor Podcast

Play Episode Listen Later Aug 2, 2021 18:42


In this two part series we talk about how there are different aspects of the visual system that can play into headaches and migraines. This episode focuses on eye strain - we will talk about the common problem of convergence insufficiency. This is a common, overlooked problem that can play a role in headaches. We will talk about all aspects of it: What is it? Who gets it? How do they get it? What nerves and muscles are impaired to cause this problem? How does it relate to headaches? How in our clinic do we assess and treat this? By the end of this episode you will fully understand convergence insufficiency and you will know what to do about it. 

RNZ: Sunday Morning
Why fruit flies, mosquitos are 'brainier' than people suspect

RNZ: Sunday Morning

Play Episode Listen Later May 22, 2021 10:33


Having trouble getting rid of fruit flies at home or in the office? Don't be surprised - they're 'brainer' than you think. Christopher Potter, associate professor of neuroscience at the Johns Hopkins University School of Medicine, explains. 

RNZ: Sunday Morning
Why fruit flies, mosquitos are 'brainier' than people suspect

RNZ: Sunday Morning

Play Episode Listen Later May 22, 2021 10:33


Having trouble getting rid of fruit flies at home or in the office? Don't be surprised - they're 'brainer' than you think. Christopher Potter, associate professor of neuroscience at the Johns Hopkins University School of Medicine, explains. 

Solarpod podcast
Élet más bolygókon (1968) 16. Vége, bizonytalan időre

Solarpod podcast

Play Episode Listen Later May 16, 2021 62:19


Sziasztok! Bizonytalan időre megszűnök, fogalmam sincs, mikor lesz újabb podcast. Köszönöm, hogy itt voltatok.... még jövök...valamikor. Intro, zene: Kieg.: A fényjátékot a Visual System készítette Thomas Vaquie https://www.thomasvaquie.com/Personal-Projects/Act-Talk-Return Melodysheep - http://melodysheep.bandcamp.com Stellardrone - http://stellardrone.bandcamp.com

Trippin' Through Time
Episode 38: Drugs in Music

Trippin' Through Time

Play Episode Listen Later Feb 1, 2021 43:40


In this episode we discuss how music and drugs have affected each other throughout history. 

Special Needs in Motion
The Bubble Space: A Visual System for Learning the Art of Communication

Special Needs in Motion

Play Episode Listen Later Jan 4, 2021 40:06


An interview with Miriam Campbell, MA, SLP, LCSW. Miriam has created a unique program for helping children learn what good communication skills look and feel like. #communication #specialneeds #adhd #autism --- Support this podcast: https://anchor.fm/specialneedsinmotion/support

Trippin' Through Time
Episode 36: What Makes a Psychedelic Part 1: Hallucinations and the Visual System

Trippin' Through Time

Play Episode Listen Later Dec 21, 2020 69:32


This episode it a little different. Randall takes us on the first step of the journey into discovering what exactly a psychedelic is. Starting with what we see. 

Max Planck Florida’s Neurotransmissions Podcast
61 - Feedforward and Feedback Loops in the Visual System

Max Planck Florida’s Neurotransmissions Podcast

Play Episode Listen Later Dec 1, 2020 41:40


On this episode Jeremy and new guest co-host Alex Gribizis chat with Dr. W. Martin Usrey, Professor and Chair of the Department of Neurobiology, Physiology, and Behavior and the University of Davis. With Dr. Usrey we learn more about the structure of the visual system, the interactions between these different structures, and things Dr. Usrey has learned along the way about mentorship.

PaperPlayer biorxiv neuroscience
Thalamic spontaneous activity coordinates the timing of corticothalamic innervation in the visual system

PaperPlayer biorxiv neuroscience

Play Episode Listen Later Nov 16, 2020


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.11.13.382366v1?rss=1 Authors: Lopez-Bendito, G., Moreno-Juan, V., Martini, F., Perez-Saiz, L., Vadeolmillos, M., Herrero-Navarro, A. Abstract: Sensory processing relies on the correct development of circuits connecting thalamus and cortex. Visual corticothalamic axons (CTAs) invade the thalamic dorsolateral geniculate nucleus (dLGN) of the thalamus following an early postnatal time-regulated programme in mice. Retinal spontaneous activity influences the thalamic incursion of CTAs, however, the perinatal thalamus also generates intrinsic patterns of spontaneous activity whose role in modulating afferent connectivity remains unknown. Here, we found that patterned spontaneous activity in the dLGN is critical for the proper spatial and temporal innervation of CTAs. When the spontaneous dLGN activity is disrupted in vivo, CTA innervation is severely delayed until eye-opening. Indeed, visual input influenced the temporal development of CTAs by modulating thalamic activity, as embryonic enucleation enhanced thalamic calcium waves and accelerated the entrance of CTAs into the dLGN. Our results show that patterned spontaneous activity in the perinatal thalamus is a key element driving the wiring of visual circuits. Copy rights belong to original authors. Visit the link for more info

Naked Neuroscience, from the Naked Scientists

This month, we're digging deeper into the world of headaches, asking what's going on in the brain when a migraine occurs? And meet the stripes that can do your head in... Like this podcast? Please help us by supporting the Naked Scientists

Naked Neuroscience, from the Naked Scientists

This month, we're digging deeper into the world of headaches, asking what's going on in the brain when a migraine occurs? And meet the stripes that can do your head in... Like this podcast? Please help us by supporting the Naked Scientists

Faces of TBI
Neuro-Optometric Rehabilitation and the Recovery of the Visual System

Faces of TBI

Play Episode Listen Later Jun 11, 2020 34:00


Dr. Megan Lott is a functional neuro-optometrist in Hattiesburg, MS. She performs visual examinations that go beyond 20/20 eyesight. She performs neuro-optometic rehabilitation for patients who have suffered a brain injury. In 2019 she was awarded the Founders Award by the Brain Injury Association of Mississippi. In 2017 she was awarded the Healthcare Hero award by the MS Business Journal for her work in optometry in the state of MS.  www.bellevuesec.com This episode is brought to you by: Integrated Brain Centers

WO Voices
Dr. Debby Feinberg: The Need for Neurovisual Optometry Is Huge

WO Voices

Play Episode Listen Later Jan 21, 2020 22:15


Debby Feinberg, OD, FAAO, of Bloomfield Hills, Michigan, is one of the leading voices in the field of neurovisual optometry. She has trained 27 eye care practitioners in her method of providing fast help to patients who suffer from congenital or acquired issues with balance, dizziness, nausea and anxiety due to visual issues. Dr. Feinberg is a 2018 Women In Optometry Theia Award winner for innovation. Take me back to the Specialty Services cover story package.

AV Experts Podcast
3 Essentials for Every Spa and Massage Parlor Audio Visual System

AV Experts Podcast

Play Episode Listen Later Aug 25, 2019 28:31


In this episode of #avexpertspodcast Pope and I explore the importance of touching all 5 senses when designing a cutting edge spa audio visual solution. #avexpertspodcast #longliveAV. This episode is brought to you by www.innofacesystems.com your one stop source for state of the art audio visual design and integration services. Phone: 1-877-721-4040

Curiosity Daily
Developing Drugs to Fight Superbugs (w/ Dr. Matt McCarthy) and What Dark Mode Does

Curiosity Daily

Play Episode Listen Later Jun 20, 2019 9:54


Learn about whether dark mode really is easier on your eyes, according to research. Then, learn about how new antibiotics are being developed with Dr. Matt McCarthy, author of the new book “Superbugs: The Race to Stop an Epidemic.” In this podcast, Cody Gough and Ashley Hamer discuss the following story from Curiosity.com about whether dark mode really is easier on your eyes: https://curiosity.im/2Wf2xMI Additional resources from Dr. Matt McCarthy: Pick up “Superbugs: The Race to Stop an Epidemic” on Amazon — https://amzn.to/2ENNpuW Official website — http://www.drmattmccarthy.com/ Follow @DrMattMcCarthy on Twitter — https://twitter.com/drmattmccarthy What Superbug Hunters Know That We Don’t | The New York Times — https://www.nytimes.com/2019/05/20/opinion/hospitals-antibiotic-resistant-bacteria-superbugs.html If you love our show and you're interested in hearing full-length interviews, then please consider supporting us on Patreon. You'll get exclusive episodes and access to our archives as soon as you become a Patron! https://www.patreon.com/curiositydotcom Download the FREE 5-star Curiosity app for Android and iOS at https://curiosity.im/podcast-app. And Amazon smart speaker users: you can listen to our podcast as part of your Amazon Alexa Flash Briefing — just click “enable” here: https://curiosity.im/podcast-flash-briefing.

AV Experts Podcast
3 Must Haves For Every Sports Bar And Restaurant Audio Visual System By #avexpertspodcast

AV Experts Podcast

Play Episode Listen Later Jun 10, 2019 20:55


On this episode of AV Experts Podcast we touch on 3 things that we think every sports bar and restaurant AV system should have. This episode is brought to you by www.innofacesystems.com 1-877-721-4040- Your one stop shop for custom audio visual solutions.

The Naked Scientists Podcast
Extremely Fast: The Science of Speed

The Naked Scientists Podcast

Play Episode Listen Later Jun 3, 2019 57:09


This week, we're kicking off a month of science at the extremes. From fast acting venom to vehicles, speedy space to tennis serves... We're getting up to speed on Extreme Speed. Plus, in the news, weaponising a fungus to stamp out malaria, the smart glove that's taking a hold of touch technology and we celebrate an important centenary in the world of physics. Like this podcast? Please help us by supporting the Naked Scientists

The Naked Scientists Podcast
Extremely Fast: The Science of Speed

The Naked Scientists Podcast

Play Episode Listen Later Jun 3, 2019 57:09


This week, we're kicking off a month of science at the extremes. From fast acting venom to vehicles, speedy space to tennis serves... We're getting up to speed on Extreme Speed. Plus, in the news, weaponising a fungus to stamp out malaria, the smart glove that's taking a hold of touch technology and we celebrate an important centenary in the world of physics. Like this podcast? Please help us by supporting the Naked Scientists

The Kathryn Zox Show
Ep. 1: Career Connections and Ep. 2: How Vision Works

The Kathryn Zox Show

Play Episode Listen Later Mar 6, 2019 54:51


Kathryn interviews President & CEO of Tallo Casey Welch. The organization has partnered with more than 300 companies and colleges to improve workforce diversity, proactively engage the country's talent pipeline, foster growing apprenticeship programs and engage with local communities. In 2018, Tallo connected students from more than 2,000 colleges and nearly 20,000 high schools in all 50 states with potential career pathways, jobs and apprenticeships and scholarship opportunities. Kathryn also interviews Author & Professor at Harvard University John E. Dowling, PhD, author of the book “Vision: How It Works and What Can Go Wrong”. Over the past fifty years, enormous progress has been made in understanding visual mechanisms and treating eye disorders. He discusses what could potentially go wrong within our complex visual system, surveys the evolution of our knowledge of vision, and speculates about future advances.

The Kathryn Zox Show
Ep. 1: Career Connections and Ep. 2: How Vision Works

The Kathryn Zox Show

Play Episode Listen Later Mar 6, 2019 54:51


Kathryn interviews President & CEO of Tallo Casey Welch. The organization has partnered with more than 300 companies and colleges to improve workforce diversity, proactively engage the country's talent pipeline, foster growing apprenticeship programs and engage with local communities. In 2018, Tallo connected students from more than 2,000 colleges and nearly 20,000 high schools in all 50 states with potential career pathways, jobs and apprenticeships and scholarship opportunities. Kathryn also interviews Author & Professor at Harvard University John E. Dowling, PhD, author of the book “Vision: How It Works and What Can Go Wrong”. Over the past fifty years, enormous progress has been made in understanding visual mechanisms and treating eye disorders. He discusses what could potentially go wrong within our complex visual system, surveys the evolution of our knowledge of vision, and speculates about future advances.

The Healthcare Education Transformation Podcast
Dr. William Padula & Jeremiah Jorgensen : Neuro-Optometric Rehabilitation Part 2

The Healthcare Education Transformation Podcast

Play Episode Listen Later Jul 30, 2018 34:12


Today we welcome Dr. William Padula and Jeremiah Jorgensen for a a discussion on neuro-optmetric rehabilitation in which this is part 2 of this discussion. They discuss their stories on how they got to where they are now, what neuro-optometric rehabilitation is and what it can treat, the evidence behind this approach and the limitations of that evidence, top clinical pearls regarding vision rehab for all healthcare providers, and much more!    Padula Institute of Vision Rehabilitation Website: http://padulainstitute.com/  Dr. Padula's Twitter Page: https://twitter.com/DrBillPadula   Dr. Padula's Email Address: wvpadula@me.com   Somatosensory Recalibration of the Visual Systems class: http://class.ptlincoln.com/  Jeremiah's Facebook Page: https://www.facebook.com/jeremiah.jorgensen.5  Jeremiah's Twitter Page: https://twitter.com/Lincoln_PT  Jeremiah's Instagram Page: https://www.instagram.com/jeremiahjorgensen/  Center for Spine & Sport Rehab Website: http://www.ptlincoln.com/  Center for Spine & Sport Rehab Facebook Page: https://www.facebook.com/PTLincoln/    The PT Hustle Website: https://www.thepthustle.com/  Schedule an Appointment with Kyle Rice: www.passtheptboards.com    HET LITE Tool: www.pteducator.com/het     Biography: Dr. William Padula internationally known optometrist, author, researcher, educator and founder of the Padula Institute of Vision Rehabilitation ( Providing neuro-optometric rehabilitation for children and adults with reading and learning disabilities as well as  for those persons who have neurological problems caused by traumatic brain injury (TBI), stroke, (CVA), autism (ASD), chronic fatigue syndrome, (CFIDS), multiple sclerosis (MS), and cerebral palsy (CP),) and leader in the diagnosis of Lyme Disease William V. Padula, O.D., is a graduate of Pennsylvania College of Optometry at Salus University of Health Sciences. He is a Fellow of the American Academy of Optometry, the Neuro-Optometric Rehabilitation Association International (NORA), and the National Academy of Practice. Dr. Padula completed a fellowship at the Gesell Institute where he was also Director of Vision Research.  He was the founding Chairman of the Low Vision Section for the American Optometric Association, and the founding President of NORA.  Dr. Padula was appointed the National Consultant in Low Vision Services for the American Foundation for the Blind.  He has also served as Consultant to the Committee on Vision for the National Academy of Sciences in Washington, D.C. Recently he has served as a consultant to the Walter Reed Hospital in Washington, D.C. He is the Past Chairperson of the National Academy of Practice in Optometry, and is the Treasurer of the National Academy of Practice (NAP). Dr. Padula founded the first low vision clinic at the Zhongshan Eye Research Hospital in Guangzhou, People's Republic of China, which was named in his honor. He lectures and consults internationally in China, India, Italy, Mexico, etc., with programs regarding children's vision related to learning and development, and adult vision problems related to stroke, TBI and other physical challenges. Dr. Padula has authored numerous publications including three books: A Behavioral Vision Approach for Persons With Physical Disabilities Neuro-Optometric Rehabilitation Neuro-Visual Processing Rehabilitation: An Interdisciplinary Approach and he is the primary author of a chapter on vision in Brain Injury Medicine.  He has developed three award winning educational videotapes about vision and Neuro-Optometric Rehabilitation for persons with neurological challenges.  He also holds five U.S. patents for instruments related to vision. Dr. Padula is on staff at both the Hospital for Special Care and Gaylord Hospital in Connecticut, and he has a private practice in Guilford, Connecticut. He was honored to be chosen Connecticut Optometrist of the Year in 2009 by his colleagues in the Connecticut Association of Optometrists.     Jeremiah Jorgensen and Kari opened Center for Spine and Sport Rehab February 2007.   Is a Physical Therapist and Partner of Spine and Sport Rehab in Lincoln, Nebraska. Jeremiah has 14 yrs experience working in outpatient orthopedics. The initial 4 yrs were in Arizona alongside some of the the best orthopedic manual therapists in the country before returning to Nebraska.  His home town is Minden. He completed his Residency in orthopaedic manual physical therapy from The Ola Grimsby Institute which is an extensive postgraduate curriculum and clinical training for  extremity and spinal orthopaedic manual physical therapy.   Jeremiah is currently pursuing his post graduate DPT in manual therapy. Certifications include Voila Level 1, Functional Dry needling from Kinetacore Level 1, ASTYM Certification Upper and Lower extremities, and certified in the treatment of Neuropathy. He is a consultant for Neuropathy DR program as a clinical specialist and adjunct instructor and also teaches Somatosensory Recalibration via the Visual System.

The Healthcare Education Transformation Podcast
Dr. William Padula & Jeremiah Jorgensen : Neuro-Optometric Rehabilitation Part 1

The Healthcare Education Transformation Podcast

Play Episode Listen Later Jul 28, 2018 38:14


Today we welcome Dr. William Padula and Jeremiah Jorgensen for a a discussion on neuro-optmetric rehabilitation in which this is part 1 of this discussion. They discuss their stories on how they got to where they are now, what neuro-optometric rehabilitation is and what it can treat, the evidence behind this approach and the limitations of that evidence, top clinical pearls regarding vision rehab for all healthcare providers, and much more!    Padula Institute of Vision Rehabilitation Website: http://padulainstitute.com/  Dr. Padula's Twitter Page: https://twitter.com/DrBillPadula   Dr. Padula's Email Address: wvpadula@me.com  Somatosensory Recalibration of the Visual Systems class: http://class.ptlincoln.com/    Jeremiah's Facebook Page: https://www.facebook.com/jeremiah.jorgensen.5  Jeremiah's Twitter Page: https://twitter.com/Lincoln_PT  Jeremiah's Instagram Page: https://www.instagram.com/jeremiahjorgensen/  Center for Spine & Sport Rehab Website: http://www.ptlincoln.com/  Center for Spine & Sport Rehab Facebook Page: https://www.facebook.com/PTLincoln/    The PT Hustle Website: https://www.thepthustle.com/  Schedule an Appointment with Kyle Rice: www.passtheptboards.com    HET LITE Tool: www.pteducator.com/het     Biography: Dr. William Padula internationally known optometrist, author, researcher, educator and founder of the Padula Institute of Vision Rehabilitation ( Providing neuro-optometric rehabilitation for children and adults with reading and learning disabilities as well as  for those persons who have neurological problems caused by traumatic brain injury (TBI), stroke, (CVA), autism (ASD), chronic fatigue syndrome, (CFIDS), multiple sclerosis (MS), and cerebral palsy (CP),) and leader in the diagnosis of Lyme Disease William V. Padula, O.D., is a graduate of Pennsylvania College of Optometry at Salus University of Health Sciences. He is a Fellow of the American Academy of Optometry, the Neuro-Optometric Rehabilitation Association International (NORA), and the National Academy of Practice. Dr. Padula completed a fellowship at the Gesell Institute where he was also Director of Vision Research.  He was the founding Chairman of the Low Vision Section for the American Optometric Association, and the founding President of NORA.  Dr. Padula was appointed the National Consultant in Low Vision Services for the American Foundation for the Blind.  He has also served as Consultant to the Committee on Vision for the National Academy of Sciences in Washington, D.C. Recently he has served as a consultant to the Walter Reed Hospital in Washington, D.C. He is the Past Chairperson of the National Academy of Practice in Optometry, and is the Treasurer of the National Academy of Practice (NAP). Dr. Padula founded the first low vision clinic at the Zhongshan Eye Research Hospital in Guangzhou, People's Republic of China, which was named in his honor. He lectures and consults internationally in China, India, Italy, Mexico, etc., with programs regarding children's vision related to learning and development, and adult vision problems related to stroke, TBI and other physical challenges. Dr. Padula has authored numerous publications including three books: A Behavioral Vision Approach for Persons With Physical Disabilities Neuro-Optometric Rehabilitation Neuro-Visual Processing Rehabilitation: An Interdisciplinary Approach and he is the primary author of a chapter on vision in Brain Injury Medicine.  He has developed three award winning educational videotapes about vision and Neuro-Optometric Rehabilitation for persons with neurological challenges.  He also holds five U.S. patents for instruments related to vision. Dr. Padula is on staff at both the Hospital for Special Care and Gaylord Hospital in Connecticut, and he has a private practice in Guilford, Connecticut. He was honored to be chosen Connecticut Optometrist of the Year in 2009 by his colleagues in the Connecticut Association of Optometrists.     Jeremiah Jorgensen and Kari opened Center for Spine and Sport Rehab February 2007.   Is a Physical Therapist and Partner of Spine and Sport Rehab in Lincoln, Nebraska. Jeremiah has 14 yrs experience working in outpatient orthopedics. The initial 4 yrs were in Arizona alongside some of the the best orthopedic manual therapists in the country before returning to Nebraska.  His home town is Minden. He completed his Residency in orthopaedic manual physical therapy from The Ola Grimsby Institute which is an extensive postgraduate curriculum and clinical training for  extremity and spinal orthopaedic manual physical therapy.   Jeremiah is currently pursuing his post graduate DPT in manual therapy. Certifications include Voila Level 1, Functional Dry needling from Kinetacore Level 1, ASTYM Certification Upper and Lower extremities, and certified in the treatment of Neuropathy. He is a consultant for Neuropathy DR program as a clinical specialist and adjunct instructor and also teaches Somatosensory Recalibration via the Visual System.

Medical School Audio
NB49 Visual System and Retina

Medical School Audio

Play Episode Listen Later Mar 29, 2018 44:21


--- Support this podcast: https://anchor.fm/brad-richardson/support

Listening in on LEEP
Visual System- Listening In On LEEP - With Dir. of O.T. Michaja Johnson

Listening in on LEEP

Play Episode Listen Later Dec 7, 2017 30:05


Today's Episode continues the conversation about Sensory-Integration focusing on the Visual System Programs featuring LEEP Forward's Director of Occupational Therapy Michaja Prendergast. You are Listening in on LEEP Forward Pediatric Development Clinic and Theraputic preschool and transitional kindergarten team of experts talking about topics parents and teachers care about. LEEP Forward has experts in the fields of Occupational Therapy, Speech and Launguage Pathology, Social Work, Developmental Therapy and Early Intervention. To speak with the experts on this podcast or talk to someone at LEEP about your child you can find us at LEEPforward.com Music: www.bensound.com

Braille Institute Podcasts
The Visual System, Sep 13, 2016

Braille Institute Podcasts

Play Episode Listen Later Oct 19, 2016 47:49


Dr. Bill gives a thorough explanation of how the visual system works and what could go wrong with it.

Braille Institute Podcasts
The Visual System, Sep 13, 2016

Braille Institute Podcasts

Play Episode Listen Later Oct 18, 2016 47:49


Dr. Bill gives a thorough explanation of how the visual system works and what could go wrong with it.

Sensory Systems
Lecture 1: Introduction, the visual system

Sensory Systems

Play Episode Listen Later Jun 17, 2015 74:41


This lecture covers the layout and organization of the course, as well as separate introductions to the visual system and the auditory system.

Sensory Systems
Lecture 2: Basic layout of the visual system and the retina

Sensory Systems

Play Episode Listen Later Jun 17, 2015 81:42


This video covers the basic layout and components of the visual system, including retinal ganglion cells, photoreceptors, biopolar, horizontal and amacrine cells.

Lykken on Lending
11-24-14 SPECIAL GUEST: David Lord "Increasing Profits via Process Improvement"

Lykken on Lending

Play Episode Listen Later Nov 24, 2014 59:24


Process improvement is certainly not a new topic but we often need to be reminded of the impact it can have on our companies.  Today's guest, David T. Lord, helps a company identify the processes that need improvement, then, shows how to make the improvements a reality. David's particular area of expertise is visual management for enhancing communication and accelerating project completion. His method and tools show companies how to develop business cultures that continuously improve while being committed to employees and customers. David's book, The Visual System of Work: Help Your business Work Better, Make Money and Generate Cash, A 90 Day Implementation Guide, outlines the method and tools. Over 100 businesses have utilized David's method and tools in the past 25 years…many continuing their journey with him today. Created BY mortgage professional FOR mortgage professionals, Lykken on Lending is a weekly 60-minute radio program normally hosted by mortgage veteran, David Lykken.  However, this broadcast will be hosted by Alice Alvey.

Fakultät für Biologie - Digitale Hochschulschriften der LMU - Teil 05/06

Wed, 22 Oct 2014 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/17558/ https://edoc.ub.uni-muenchen.de/17558/1/Lehmann_Tobias.pdf Lehmann, Tobias ddc:570, ddc:500, Fakultät für Biologie

11/12(1) BMSC2118 Neurobiology (25953) Podcast

Fri, 04 Nov 2011 14:25

Fakultät für Biologie - Digitale Hochschulschriften der LMU - Teil 04/06
Golden Goal collaborates with Flamingo in synaptic-layer targeting in the Drosophila visual system

Fakultät für Biologie - Digitale Hochschulschriften der LMU - Teil 04/06

Play Episode Listen Later Jul 14, 2011


Thu, 14 Jul 2011 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/13412/ https://edoc.ub.uni-muenchen.de/13412/1/Mueller_Sandra.pdf Mueller, Sandra ddc:570, ddc:5

Question of the Week - From the Naked Scientists
Why does an electric toothbrush affect my vision?

Question of the Week - From the Naked Scientists

Play Episode Listen Later Jul 4, 2010 4:29


When brushing one's dental equipment with an electric toothbrush one may notice a slight wobbling of the television images. Why does this happen? Plus, we ask why the Americas hadn't developed the same kinds of technologies as the Old World at the time of European contact. Like this podcast? Please help us by supporting the Naked Scientists

Fakultät für Biologie - Digitale Hochschulschriften der LMU - Teil 03/06
Effect of temperature and light intensity on the representation of motion information in the fly's visual system

Fakultät für Biologie - Digitale Hochschulschriften der LMU - Teil 03/06

Play Episode Listen Later Apr 7, 2009


To comprehend how the brain performs efficient computation, it is important to understand the way sensory information is represented in the nervous system. Under natural conditions, sensory signals have to be processed with sufficient accuracy under functional and resources constraints. Here I use motion vision in the fly Calliphora vicina to study the influence of two behaviorally relevant environmental properties - temperature and light intensity - on the representation of motion information in the responses of the neuron H1. The goal was to quantify how these environmental properties affect the response variability, information content, coding efficiency and temporal scale. I show that the firing precision is determined largely by the light intensity rather than by temperature. Moreover, a better firing precision barely improves the information rate, which closely follows the mean firing rate. Altogether, my results suggest that the robustness of the motion information processing against temperature variations depends on the quality of the input signal. Furthermore, flies seem to use the input signal-to-noise ratio to improve the information rate and reduce the time-scale of the response simultaneously, by increasing the mean firing rate, rather than the firing precision.

Web Directions Podcast
Five Essential Composition Tools for Web Typography - Kimberly Elam

Web Directions Podcast

Play Episode Listen Later Apr 14, 2008 55:53


Have you ever seen a web site so clear, logical, and exquisitely composed it made you stop in your tracks? Have you wondered how the designer achieved such a stunning and cohesive design? In this presentation, Kimberly Elam, designer and author of the best-selling "Geometry of Design" and "Typographic Systems" will reveal the mysterious relationships between proportion, visual systems, composition and aesthetics. Too often excellent conceptual ideas suffer during the process of realization, in large part because the designer did not understand the essential visual principles. This presentation explores these elements and how they work by examining how the use of visual principles informs, even creates, beauty in typographic design, but, more importantly, how you can use these techniques to create cohesiveness in your own design. The wide range of visual examples are both informative and insightful, and any designer can benefit from learning or revisiting the rules governing the basics of typographic design. Kimberly Elam is a writer, educator, and graphic designer. She is currently the Chair of the Graphic & Interactive Communication Department at the Ringling College of Art + Design, Sarasota, Florida, where she has developed an academic minor in the Business of Art and Design. Her first book, Expressive Typography - Word as Image, identifies and analyzes methods by which words can transcend didactic meaning and become images. Geometry of Design - Studies in Proportion and Composition, visually illustrates the connection between classic proportioning systems and modern graphic design, industrial design, illustration, and architecture. Grid Systems - Principles of Organizing Type puts forth a clear methodology for understanding and learning the grid system of composition. Her most recent book, Typographic Systems - Rules for Organizing Type presents an innovative series of nontraditional, rule-based, visual language systems for typographic composition. Her current work focuses on the development of a series of innovative ebooks and print-on-demand books for design education on her website, StudioResourceInc.com. Licensed as Creative Commons Attribution-Share Alike 3.0 (http://creativecommons.org/licenses/by-sa/3.0/).

Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 07/19
Differences in Activation of the Visual System in Mild Cognitive Impaired Subjects compared to Healthy Subjects measured using functional magnetic resonance imaging (fMRI)

Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 07/19

Play Episode Listen Later May 24, 2007


Introduction: Mild Cognitive Impairment (MCI) is a cognitive stage between normal aging and Dementia. It is a heterogeneous group of patients, where most of them develop Alzheimer’s disease (AD), others stabilize, and a few revert to normal. AD’s first clinical symptoms are related to memory, but it has been shown that AD involves also a processing disorder in the visual sensory pathways. Accurate visual function facilitates memory, attention and executive functions, so that perceptual dysfunction contributes to the severity of cognitive impairment. Objective: The objective of the work is to measure changes in activation in the visual system between MCI patients and old Healthy Control (HC) subjects, using two different visual processing tasks with functional Magnet Resonance Imaging (fMRI). This is the first study which makes such a comparison between MCI and HC using fMRI. Methods: Brain activation was measured using fMRI. The MCI group was composed of 16 subjects and the HC group was composed of 19 subjects. All subjects performed two tasks: location matching (position of objects) and face matching (characteristics of the objects), which selectively activate one of the visual system pathways in healthy people. Answers were given by pressing a single button. Results: Performance of the task was not significantly different in both groups. The HC group selectively activated ventral pathway for face matching and the dorsal pathways for location matching. In contrast the MCI subjects did not selectively activate the ventral and dorsal pathways of the visual system. Additionally they showed higher activation in the left frontal lobe compared to HC when performing the location matching Task Conclusions: The results suggest that even when behavioural performance between groups is the same, the neural system which supports performance may differ. MCI subjects compensate their deficits using additional brain areas to help them to maintain performance. In this case MCI subjects used the left frontal lobe in addition to perform the location matching task. This work presents the usability of brain imaging techniques especially fMRI to better understand the underlying pathology of MCI and its subtypes as prodromal conditions of AD.

Neuroscience & Behavior
Lecture 29: Visual System 4: Ablations (cont.) (Orig: Electrophysiology)

Neuroscience & Behavior

Play Episode Listen Later Apr 25, 2007 39:39


This course covers the relation of structure and function at various levels of neuronal integration. Topics include functional neuroanatomy and neurophysiology, sensory and motor systems, centrally programmed behavior, sensory systems, sleep and dreaming, motivation and reward, emotional displays of various types, "higher functions" and the neocortex, and neural processes in learning and memory.

Neuroscience & Behavior
Lecture 28: Visual System 3: Ablation Studies

Neuroscience & Behavior

Play Episode Listen Later Apr 25, 2007 43:59


This course covers the relation of structure and function at various levels of neuronal integration. Topics include functional neuroanatomy and neurophysiology, sensory and motor systems, centrally programmed behavior, sensory systems, sleep and dreaming, motivation and reward, emotional displays of various types, "higher functions" and the neocortex, and neural processes in learning and memory.

Neuroscience & Behavior
Lecture 27: Visual System 2: Physiology (orig: Ablation Effects); Neville Sanjana, Guest lecturer

Neuroscience & Behavior

Play Episode Listen Later Apr 25, 2007 51:57


This course covers the relation of structure and function at various levels of neuronal integration. Topics include functional neuroanatomy and neurophysiology, sensory and motor systems, centrally programmed behavior, sensory systems, sleep and dreaming, motivation and reward, emotional displays of various types, "higher functions" and the neocortex, and neural processes in learning and memory.

Neuroscience & Behavior
Lecture 26: Visual System 1: Anatomy, Ablations

Neuroscience & Behavior

Play Episode Listen Later Apr 25, 2007 39:17


This course covers the relation of structure and function at various levels of neuronal integration. Topics include functional neuroanatomy and neurophysiology, sensory and motor systems, centrally programmed behavior, sensory systems, sleep and dreaming, motivation and reward, emotional displays of various types, "higher functions" and the neocortex, and neural processes in learning and memory.

Videocast Podcasts for NINDS
Multiple Mechanisms of Activity-Dependent Visual System Development

Videocast Podcasts for NINDS

Play Episode Listen Later Jan 30, 2007 58:44


Enhanced Audio PodcastAired date: 12/18/2006 12:00:00 PM Eastern Time Institute: NINDS

Videocast Podcasts
Multiple Mechanisms of Activity-Dependent Visual System Development

Videocast Podcasts

Play Episode Listen Later Jan 30, 2007 58:44


Enhanced Video PodcastAired date: 12/18/2006 12:00:00 PM Eastern Time

Videocast Podcasts
Multiple Mechanisms of Activity-Dependent Visual System Development

Videocast Podcasts

Play Episode Listen Later Jan 30, 2007 58:44


Enhanced Audio PodcastAired date: 12/18/2006 12:00:00 PM Eastern Time

Videocast Podcasts for NINDS
Multiple Mechanisms of Activity-Dependent Visual System Development

Videocast Podcasts for NINDS

Play Episode Listen Later Jan 30, 2007 58:44


Enhanced Video PodcastAired date: 12/18/2006 12:00:00 PM Eastern Time Institute: NINDS

Fakultät für Biologie - Digitale Hochschulschriften der LMU - Teil 02/06
Imaging development and plasticity in the mouse visual system

Fakultät für Biologie - Digitale Hochschulschriften der LMU - Teil 02/06

Play Episode Listen Later Jun 22, 2006


Neuronal activity, both intrinsically generated and sensory-evoked, is known to play an important role in the development of the brain. Sensory experiences continue to exert a strong influence on the functional connectivity of neuronal circuits, especially in the cerebral cortex, allowing for learning and adaptation to an ever changing environment. The visual system provides a convenient and well established model to study both development and experience-dependent plasticity of neuronal circuits. The aim of this thesis is to employ the mouse visual system to explore how neuronal activity influences the formation of brain circuits and mediates their experience-dependent modification later in life. In the first part of this thesis (Chapter 2), I examined the role of retinal activity in the formation of topographic maps in a target region of retinal ganglion cells. It is generally assumed that in order to obtain such highly precise and ordered maps during development, spontaneous patterns of neuronal activity are crucial for the refinement of connections. Applying intrinsic signal imaging to mouse superior colliculus (SC), I confirmed this assumption by showing that functional connectivity is less precise in transgenic mice with disrupted patterns of retinal ganglion cell activity. In comparison to normal mice, visual stimuli activated larger, less defined regions in the SC in mice lacking early retinal waves. Surprisingly, I also found that the overall topographic organization was affected by the lack of correlated spiking in the retina. Although the rough retinotopic organization was maintained, the map showed substantial distortion, indicating that patterned retinal activity before eye-opening plays a more important role in topographic map formation than previously thought. Later in development, sensory-evoked activity is equally influential in shaping functional connectivity, since altered sensory input induces strong changes in cortical circuitry. Closure of one eye for a few days (monocular deprivation, MD), for instance, substantially changes cortical responsiveness to the two eyes, shifting ocular dominance (OD) towards the non-deprived eye. This paradigm therefore provides a powerful model system for experience-dependent plasticity. In Chapter 3, I used intrinsic signal imaging to assess the magnitude of cortical responses evoked by stimulation of the two eyes in order to explore OD plasticity in mouse visual cortex. I confirmed recent, debated findings in demonstrating strong MD-induced plasticity in adult animals, which was mediated by partly different mechanisms than in juvenile mice. I also found that restoring binocular vision after MD led to full recovery of eye-specific responses at all ages. Interestingly, the prior experience of altered sensory input seemed to be somehow preserved in cortical circuits, such that subsequent cortical adaptation to the same experience was improved. A second MD resulted in much faster and more persistent OD shifts. This enhancement of plasticity was highly specific, as it was only observed for repeated deprivation of the same eye, indicating that a lasting trace was established in cortical connections by the initial experience. In Chapter 4, I explored OD plasticity in greater detail by monitoring network activity at the level of individual neurons with in vivo two-photon imaging of calcium signals. Monitoring calcium transients associated with neuronal activity in up to hundred cells simultaneously, enabled me to examine MD-induced changes in the functional properties of each neuron independently. I found that, in general, deprived eye responses were weakened and non-deprived eye responses strengthened after MD in juvenile mice, as was expected from previous population response measurements. Neurons still dominated by deprived-eye inputs, however, did not lose their responsiveness, but rather exhibited enhanced responses following MD. This strongly suggests that homeostatic plasticity acted on these cells during deprivation and caused an up-scaling of their responsiveness, while neurons also receiving substantial input from the non-deprived eye shifted their responsiveness towards that eye. Both competitive and homeostatic processes therefore seem to operate during OD plasticity, depending on the distribution of functional inputs in individual cells. In conclusion, the work presented in this thesis provides further insight into the role of activity-dependent mechanisms in determining and shaping functional connectivity in the brain.

Biologie - Open Access LMU - Teil 01/02
The visual system in teleost fishes

Biologie - Open Access LMU - Teil 01/02

Play Episode Listen Later Jan 1, 1988


Fri, 1 Jan 1988 12:00:00 +0100 http://epub.ub.uni-muenchen.de/3304/ http://epub.ub.uni-muenchen.de/3304/1/3304.pdf Northcutt, R. G.; Wullimann, Mario F. Northcutt, R. G. und Wullimann, Mario F. (1988): The visual system in teleost fishes. morphological patterns and trends. In: Atema, J.; Fay, R. R.; Popper, A. N. und Tavolga, W. N. (Hrsg.), Sensory Biology of Aquatic Animals. Springer: New York u.a., pp. 515-552. Biologie