The Heart of Healthcare with Halle Tecco

We're back with our monthly rundown of the top headlines in health tech!Today, Halle and Steve sort through the biggest stories shaping the year ahead, from AI prescribing to lawsuits galore.We cover:AI prescribing (in Utah!)The FDA updated guidance on clinical decision support for AI in medicineThe lawsuit against Prenuvo after a missed stroke warning, and the broader debate over accountability in AI-assisted diagnosticsTexas' antitrust case against Epic - are they being anti-competitive?New evidence shows GLP-1 drugs lower employer healthcare costs by 9%Why healthcare hiring is slowing downHalle's book is now available! (Order now on Amazon)Show notes:Utah begins pilot of prescribing AI medication (Utah Department of Commerce)FDA issues guidance on wellness products, clinical decision support software (AHA)Man got $2,500 whole-body MRI that found no problems—then had massive stroke (Ars Technica)Texas sues Epic, accusing it of running a monopoly (Wisconsin Public Radio)Why cover GLP-1s? They'll lower employer healthcare costs, study says (Healthcare Dive)Hospitals' make-or-break year (Axios)

It has been said that we don't have “big data” in healthcare, but instead a large amount of “small data.”In this episode, Halle speaks with Kyle Armbrester, CEO of Datavant and former CEO of Signify Health (acquired for $8B), about why healthcare data still moves the way it did decades ago and what it will take to modernize it at scale. Kyle reflects on building and leading large health tech companies and explains how fixing data flow could reduce administrative waste, improve security, and make care easier for patients and providers alike.We cover:Why healthcare billing still happens after the fact and how that fuels administrative wasteHow missing data standards led to fax-based workflows and brittle systemsWhy healthcare data is such an attractive target for cyberattacksHow clinical data can be shared digitally without being owned or resoldLeadership lessons from scaling companies through IPOs and acquisitions—About our guest: Kyle Armbrester is Chief Executive Officer of Datavant, a healthcare data platform company with a mission to make the world's health data secure, accessible, and actionable. Datavant operates the largest and most diverse health data exchange in the U.S., connecting more than 70 percent of the 100 largest health systems, all U.S. payers, and 300 plus real world data partners.Previously, Kyle served as CEO of Signify Health, where he led more than 200 percent revenue growth, took the company public in 2021, and guided its acquisition by CVS Health in 2023 for approximately $8 billion. He later served on the CVS Health executive management team, overseeing healthcare delivery strategy and interoperability.Earlier in his career, Kyle was Chief Product Officer and Head of Corporate Development at athenahealth, where he helped scale revenue from $320 million to $1.2 billion and launched the company's partnership marketplace. Kyle has served on multiple healthcare boards and holds an MBA and AB from Harvard University.—Chapters:00:01:20 Introduction to Kyle Armbrester and his journey in healthcare00:03:58 The impact of Athena Health on healthcare innovation00:06:20 Datavant: Revolutionizing health data interoperability00:08:15 The role of Datavant in reducing administrative burden00:12:20 Understanding Datavant's value proposition across stakeholders00:14:00 Consumer products and data accessibility at Datavant00:18:25 The scale and impact of Datavant in healthcare00:19:35 Cybersecurity challenges in healthcare data management00:23:57 Bridging the gap in healthcare regulations00:26:13 Unlocking the value of untapped healthcare data00:29:25 Challenges of value-based care models00:33:23 The reality of being a CEO in healthcare00:37:00 Navigating IPOs vs. Acquisitions00:39:44 Innovating healthcare incentives for better outcomes—Pre-order Halle's new book, Massively Better Healthcare.—

This week, Steve sits down with Ankit Jain, co-founder and CEO of Infinitus Systems, to talk about why voice-based AI has become one of the most rapidly adopted tools in healthcare operations, what's actually working in the field, and where the hype still outpaces reality. Ankit shares six years of lessons from building AI agents that handle 35-minute medical calls end to end, plus his predictions on what 2026 and 2027 will really look like as enterprises attempt to build their own agents.We cover:Why so much of healthcare still runs on phones, faxes, and portalsHow AI agents are handling long, high-stakes medical calls without going off trackWhat large enterprises now expect around security, governance, and zero-hallucination requirementsWhy providers, payers, and pharma are adopting AI for different operational workflowsWhy 2026 may be the year many health systems try to build their own agents, and why most will return to vendors by 2027—About our guest: Ankit Jain is the co-founder and CEO of Infinitus Systems, the agentic healthcare communications platform that automates high-stakes clinical and administrative conversations at scale. Under his leadership, Infinitus supports 44% of the Fortune 50, and many of the largest healthcare organizations in the US. A serial entrepreneur, advisor, and investor, Ankit has built companies and guided innovation at the intersection of technology and AI. He founded Quettra (acquired by Similarweb), helped launch Google Play and the search engine Cuil, and went on to co-found and manage Gradient Ventures, Google's AI-focused venture fund. His background in building distributed systems and safety-constrained AI, combined with hands-on experience scaling products in regulated environments, gives him a pragmatic perspective on how to design trustworthy AI that earns adoption in healthcare. Ankit frequently works with industry leaders on governance, education, and integration strategies that make automation safe, approachable, and scalable.—Chapters:00:01:38 Introduction to Ankit Jain and Infinitus Systems00:02:54 The journey into healthcare entrepreneurship00:03:55 Inspiration behind Infinitus and its mission00:04:55 Evolution of AI in healthcare communications00:08:12 Navigating competition in the AI healthcare space00:10:30 Defensibility and product development insights00:14:00 AI's role in enhancing healthcare accessibility00:15:20 Go-to-Market strategies and lessons learned00:17:52 Deepening engagement in healthcare workflows00:19:33 Competitive dynamics in healthcare AI00:20:42 Addressing industry concerns and challenges00:22:14 The need for industry self-regulation00:23:40 Navigating consumer privacy and AI interactions00:25:27 The future of jobs in healthcare AI00:28:30 The evolution of healthcare AI00:29:37 Lessons for entrepreneurs in healthcare—Pre-order Halle's new book, Massively Better Healthcare.—

Is 2026 the year that changes everything in healthcare?Steve and Halle sit down with legendary healthcare VC Annie Lamont for their annual predictions episode to dive into 2026 predictions and trends that founders and operators should pay attention to. We cover:

For our first episode of 2026, Dr. Ezekiel “Zeke” Emanuel, oncologist, bioethicist, architect of the Affordable Care Act, and author of Eat Your Ice Cream joins us to share why he believes the longevity movement is overblown and how real health comes down to simplicity. In his new book, Zeke argues that instead of chasing expensive fads and wellness trends, we should focus on six straightforward habits that make life healthier and more enjoyable. In this conversation with co-host Steve Kraus, he explains why complexity is one of healthcare's biggest threats, how public frustration is reshaping policy, and why the path to better health may be far simpler than we think.We cover:

We're closing out the year with a candid conversation about where America is headed.For our final episode of 2025, Halle and Steve sit down with entrepreneur and former presidential candidate Andrew Yang to talk plainly about the forces reshaping American life, from rising healthcare costs and gaps in coverage to AI-driven job disruption and the strain on the social safety net. We cover:

Many clinicians quietly wonder if there's a “next chapter” beyond the hospital walls, and an increasing number are stepping into health tech roles that didn't exist a decade ago.Dr. Reena Pande has lived that shift firsthand: from cardiologist at a top academic center, to early employee and CMO at AbleTo, to now leading clinician executive search at Oxeon. She joins us to unpack what it really takes for clinicians to succeed in startups, why these roles matter more than ever, and how AI is reshaping both medical training and leadership.We cover:

Hemant Taneja believes you can sneeze and reach a billion dollars in healthcare revenue, but that most of that revenue tells you nothing about whether the system is actually getting better.This week, Halle sits down with the CEO of General Catalyst and author of The Transformation Principles to discuss what happens when you stop treating revenue as the primary KPI and start asking harder questions about impact, incentives, and system change. They get into his “health assurance” thesis, what it means for a VC firm to buy a hospital, why “profit-only” capitalism has run its course, and how AI and new payment models could finally bend the cost curve instead of just inflating it.We cover:

The Haves & Have-Nots Of 2025 | Threshold Ventures Co-founder Emily MeltonThis week for our 2025 recap, we're joined by VC Emily Melton, co-founder of Threshold Ventures. Melton highlights her reflection of 2025, which splits the market into "haves and have-nots" with nothing in between, noting the concentration of venture dollars on "high flyers" and the indifference shown to established companies with respectable revenue.We cover:

The first trillion-dollar healthcare company, a $298M longevity round, and a telehealth CEO headed for federal sentencing. Last month had range.Today on the show, Halle and Michael sort through the biggest December stories shaping the year ahead, from runaway longevity funding to a telehealth scandal headed for federal sentencing.We cover:

As millions of Americans hit the road to visit family for Thanksgiving, many will pass through, or return to, rural communities. Nearly 60 million Americans live in these areas, yet many struggle to access even basic healthcare as rural hospitals close at record rates.Dr. Jennifer Schneider, co-founder and CEO of Homeward Health, is tackling this crisis head-on by reimagining how care is delivered to Medicare Advantage members in rural America. Drawing on her experiences as a physician, a patient with Type 1 diabetes, and the former president of Livongo, Jenny shares why rural healthcare is both a massive challenge and an untapped opportunity.We cover:

On the heels of raising $210 million at a $3.5 billion valuation, OpenEvidence is the fastest-growing physician app in history, now reaching over 40% of U.S. physicians and powering 17 million monthly clinical queries.In this conversation, co-founder and CTO Zack Ziegler shares how his background in early large language models led him to build an AI that helps clinicians make better decisions at the point of care, without replacing their judgment.We cover:

A billion-dollar startup. A promise to change healthcare forever. And behind the scenes… a massive lie.Tyler Shultz was just starting his career when he joined Theranos, only to discover that the company's breakthrough blood tests didn't actually work. Speaking up meant risking everything—his career, his family relationships, and his personal safety—but it also helped expose one of the biggest frauds in Silicon Valley history.In this conversation, Tyler shares what it was really like inside Theranos, how he found the courage to blow the whistle, and what leaders today can learn about building ethical cultures that last.We cover: ⚖️ What it was like working inside Theranos

Does it feel like we packed in a decade of progress this year in digital health? We think so. Today, Halle and Steve break down the biggest digital health stories of the moment, from funding trends to AI rivalries and new rules shaping the future of care.We cover:

Over 3 million clinicians around the world depend on UpToDate to guide patient care, and now the gold standard in clinical decision support is integrating generative AI. But in a world where AI models often hallucinate, how do you build something that doctors can actually trust?In this episode, Halle talks with Dr. Holly Urban, VP of Business Development and Strategy at Wolters Kluwer Health, about UpToDate Expert AI, a new tool trained exclusively on UpToDate's physician-authored content — not the open internet — and what it means for the future of medicine.We cover:

Most people spend over 30 hours a year dealing with customer service—on hold, repeating account numbers, and navigating endless phone trees. But what if AI could fix that without losing the human touch?Clay Bavor, co-founder of Sierra (now valued at $10B) and former VP at Google, joins us to explore how AI agents are reshaping how companies interact with customers and what that means for the most complex service industry in the world: healthcare.We cover:

This milestone 200th(!!!) episode of The Heart of Healthcare Podcast features none other than Dr. Tom X. Lee, the serial physician-founder behind Epocrates (acquired for $293M), One Medical (acquired by Amazon for $3.9B), and now Galileo, a tech-enabled medical group aiming to rewire care delivery from the ground up.We cover:

Happy Q4 Heart of Healthcare Listeners! We're back with your monthly Digital Health Download, where we discuss the biggest industry headlines of the month. We cover:

Cancer drugs cost more than ever, yet survival benefits are often modest—and in some cases, patients can't even access the care that already exists. After losing his father, Steve Jobs, to pancreatic cancer, Reed Jobs committed himself to making this the last generation that loses parents to the disease.Reed now leads Yosemite, a venture fund spun out of Emerson Collective in 2023, alongside Investor Matt Bettonville. Yosemite pairs life sciences and digital health investments with a grantmaking model to accelerate cancer research and ensure breakthroughs actually reach patients.We cover:

Some founders win support because of their product, others because of their story. In healthcare, where trust is everything, the ability to tell a compelling and authentic narrative can make or break a company.On this episode, Halle talks with longtime friend and colleague Christina Farr—reporter turned investor and now author of The Storyteller's Advantage. Chrissy has spent thousands of hours hearing startup pitches, advising founders, and studying what makes certain stories resonate while others fall flat. She shares insights from her years as a journalist and investor, and lessons from her new book on how narrative power shapes companies and industries.We cover:

Thanks to improved accuracy and new form factors, wearables have evolved from novelty step counters to tools that can predict illness, nudge healthier behaviors, and even influence alcohol consumption. But can they really bridge the gap between consumer wellness and enterprise healthcare?In this episode, ŌURA CEO Tom Hale discusses the lessons his team has learned from developing one of the most widely used health-tracking devices. We explore what draws people to wearables, what sustains their engagement, and how these tools may be shaping behavior and healthcare itself. We cover:

AI companies are hitting growth milestones in record time—some reaching $100 million in revenue in just two years. But while this pace feels familiar in tech, healthcare has always been slower to adopt new tools. That may finally be changing.Kent Bennett and Sofia Guerra of Bessemer Venture Partners join Steve Kraus to unpack findings from Bessemer's State of AI 2025 report and what they mean for healthcare. From “supernovas” and “shooting stars” to the rise of systems of action, they explore how AI is reshaping not only software businesses but also the way doctors, health systems, and patients interact with technology.We cover:

Healthcare's “back-to-school” season delivered no shortage of big headlines! From Epic's big leap into AI to a looming insurance “blood bath,” Steve and Michael break down the stories that shaped digital health this month.We cover:

Healthcare costs keep climbing, and yet patients and employers often feel powerless to change the system. What if outsiders—those not steeped in the traditions of healthcare—are actually the ones best positioned to fix it?This special episode is a reshare from The Benefits Playbook podcast, where Halle joins Collective Health CEO Ali Diab. Together, they unpack what it takes to make health benefits simpler, more transparent, and more consumer-focused.We cover:

Hospitals are under immense pressure: burned-out clinicians, outdated systems, and rising costs have made delivering care harder than ever. Tanay Tandon, founder and CEO of Commure, shares how his team is rethinking hospital infrastructure by combining AI, forward-deployed engineering, and a provider-first mindset. Backed by over $750M in funding, Commure is using strategic M&A and next-gen tools like ambient AI to reduce administrative burden, improve revenue cycle operations, and protect clinical staff.We cover:

One in four Americans is enrolled in Medicaid, yet the system designed to support them is constantly at risk—underfunded, politically vulnerable, and often overlooked.Dr. Alastair Bell, President and CEO of Boston Medical Center Health System, shares how his organization is reimagining what it means to care for underserved populations, while managing nearly 40% of Massachusetts' Medicaid enrollees. In this conversation, we explore the financial realities of running an “essential” hospital system, the opportunities and pitfalls of Medicaid ACOs, and why AI might deepen inequity if essential providers are left behind.We cover:

Three simple questions plague every American seeking healthcare: Where should I go? When can I be seen? And how much will it cost me? Despite seeming basic, these questions have remained largely unanswerable—until now.In this episode, we explore how Heather Fernandez, co-founder and CEO of Solv, is building the infrastructure behind same-day care for 210 million Americans. We discuss how AI is finally cracking the code on price transparency and why workflow complexity can be a competitive moat in healthcare.We cover:

A new federal law is reshaping how healthcare is paid for and delivered in America.In this episode, Steve sits down with health policy expert Joe Mercer to unpack the details of the One Big Beautiful Bill Act. It's the most significant healthcare legislation since the ACA, with ripple effects across Medicaid, rural hospitals, and the ACA exchange.We cover:

Fresh off a $243 million fundraise from Oak HC/FT and A16Z, Ambience Healthcare is on a mission to kill medical billing — and build “Iron Man suits for doctors.”Today we sit down with co-founder and CEO Mike Ng to talk about how Ambience is tackling one of healthcare's most painful problems: the administrative burden that eats up 73% of a clinician's day. We cover:

Dexcom generates more than $4 billion in annual revenue and has a market cap north of $30 billion, making it one of the biggest digital health companies in the world. And it all started with a better way to measure blood sugar.In this episode, Halle is joined by Kevin Sayer, CEO of Dexcom, the company that pioneered continuous glucose monitoring (CGM). Under Kevin's leadership, Dexcom scaled from $40 million to $4 billion in revenue, became the standard of care for people with diabetes, and is now expanding into consumer wellness with its direct-to-consumer product, Stelo.We cover:

More than a thousand AI medical devices have FDA clearance, yet fewer than two percent of radiologists actually use them.In this episode, Steve sits down with Dr. Brian Anderson—CEO and co‑founder of the Coalition for Health AI—to unpack why trust, transparency, and regulation could make or break the next wave of AI‑powered medicine.We cover:

When Andrew Lacy launched Prenuvo, the medical establishment largely dismissed it as fringe. Now, some of those same skeptics are collaborating with him on research.In this episode, Halle and Michael sit down with Andrew, founder and CEO of Prenuvo, to unpack what it takes to build trust in an unconventional idea. He opens up about how a moment of personal reckoning led him to pivot from tech to healthcare—and why he believes early detection should be a fundamental right.We cover:

In their first podcast since going public, Omada Health CEO Sean Duffy joins us to reflect on the journey to bend the curve of chronic disease.From walking away from the traditional PMPM model to staying grounded in clinical outcomes, Sean shares hard-earned lessons from over a decade of building Omada—from a startup in Rock Health's Chinatown office to IPO. We cover:

Dare we say digital health is back? The IPOs are IPOing, and startups (at least the AI ones) are back raising mega rounds. In this month's Digital Health Download, Halle and Steve break down the recent headlines, including a blockbuster funding cycle for AI tools, a dramatic breakup between Novo Nordisk and Hims, and why Oregon's new law could shake up how startups structure clinical care.We cover:

What does one do after selling their company to Amazon for $1 billion? Start a new one, of course.In this episode, Halle sits down with TJ Parker, pharmacist, entrepreneur, and advocate for consumer-centric digital health. After co-founding PillPack and selling it to Amazon, TJ stayed on for four years helping build Amazon Pharmacy. Now, he's back at it with General Medicine, a new company focused on making care as seamless as any other online transaction.We cover:

Most medical care is backed by varying types of evidence, yet we apply higher standards to digital health tools before they're trusted, adopted, or reimbursed.In this special episode, guest host Lucia Savage is joined by Dr. Vindell Washington of Verily and Dr. Aaron Carroll of AcademyHealth for a candid conversation about the uneven standards we apply to digital versus traditional care. Together, they explore how we define evidence, whose voices shape that definition, and what it takes to build trust in an AI-powered healthcare future.We cover:

Most AI in healthcare promises superintelligence—but what if that's the wrong goal entirely?In this episode, Michael and Halle speak with Othman Laraki, co-founder and CEO of Color Health, to talk about why real-world care doesn't need a perfect model—it needs a better system. Othman breaks down how Color evolved from a consumer genetics startup into a nationwide virtual cancer clinic, why most diagnostics businesses fail, and how AI can actually support clinicians without trying to replace them.We cover:

Over half of Americans now live with at least one chronic condition, yet our healthcare system still revolves around episodic, reactionary care instead of continuous, coordinated support.We talk with Dr. Jaewon Ryu—former CEO of Geisinger and now CEO of Risant Health—about how integrated delivery systems are reshaping the way care is paid for and delivered. With decades of experience spanning medicine, law, government, and leadership at some of the most respected healthcare institutions, Dr. Ryu offers a rare inside look at what it takes to scale value-based care in a fragmented system.We cover:

Is the digital health IPO drought over? Halle and Michael dig into the Hinge Health IPO and what it signals for the return of digital health companies to the public markets. They explore how much equity founders typically hold at IPO, the growing role of private equity, and why down rounds aren't the deal-breaker they once were.Plus: Elizabeth Holmes' husband launches a head-scratching startup, a former McKinsey healthcare partner faces prison time, and OpenAI teams up with the FDA.We cover:

US healthcare has more unproductive labor and more unstructured data than any other industry, making it both vulnerable to disruption from generative AI and especially unprepared for it.That's the provocative thesis of Eric Larsen, president of TowerBrook Advisors. In this episode, he joins host Steve Kraus to explain why generative AI is unlike any other technology we've seen—and why the $4.9 trillion healthcare sector is uniquely exposed.We cover:

Over 160 million Americans are served by Optum, yet many still don't fully understand what it actually does—or why it matters.Dr. Patrick Conway, newly appointed CEO of Optum and former head of CMS Innovation Center and Blue Cross NC, joins Steve for a wide-ranging discussion on the state of healthcare delivery, affordability, and the potential of value-based care at a national scale. With experience spanning the frontlines of medicine to top government and corporate leadership, Conway breaks down how Optum aims to improve care while controlling costs—and why he continues to practice as a pediatric hospitalist on weekends.We cover:

Women make 80% of healthcare decisions and outspend men two to one on care—yet when it comes to designing, funding, and scaling health tech, they're still treated like a niche.In this episode, we break down the broken flywheel holding women's health innovation back including fewer growth-stage investments, limited exits, and a system not built to serve women as the primary users of care. I'm joined by Carolyn Witte, co-founder of Tia, and Katie Drasser, CEO of Rock Health, to talk about what needs to change—and how we get there.We cover:

In this month's Digital Health Download, Steve and Halle unpack the headlines shaping healthcare, policy, and technology—with an eye toward where things may be heading next. From shifting political support for Medicaid and the ACA to state-level action on PBMs, they explore the unexpected ways the system is evolving.We cover:

The average American family spends over $24,000 a year on healthcare, and costs continue to rise faster than inflation. Why can't we create a healthcare system that delivers more value for less money?In this conversation with Ann Somers Hogg, Director of Healthcare Research at the Clayton Christensen Institute, we explore the concept of "Zero Inflation Healthcare" and uncover why traditional health insurance models continue to drive costs up. Ann breaks down why many InsureTech startups initially struggled to disrupt incumbents and how a new approach to business model innovation could finally tame runaway healthcare costs.We cover:

Each year, 2 million Americans are diagnosed with cancer and face a fragmented, overwhelming healthcare system with minimal guidance between doctor visits, even as they make life-altering decisions.In this episode, we talk with Robin Shah, Founder & CEO of Thyme Care, who has devoted his 17-year career to improving oncology care and is now building a virtual support system that has already helped over 50,000 cancer patients nationwide.We cover:

Health insurance has a Net Promoter Score of around 0-10 industry-wide, one of the lowest ratings of any industry. This is exactly why the founders of Oscar Health, with no background in healthcare and a distaste for the industry, started the company in 2012. Since then, Oscar has grown to 1.7 million members, gone public, and achieved profitability—all while receiving an NPS significantly higher than the industry average.In this episode, we talk with Mario Schlosser, co-founder and CTO of Oscar Health, about building a tech-first health insurance company in an industry notorious for poor customer experiences.We cover:

In this month's Digital Health Download, Steve, Halle, and Michael take a deliberately optimistic look at key headlines in healthcare technology. From the impressive impact of AI scribing tools on physician satisfaction to encouraging survival rates among digital health unicorns from the ZIRP-era, the hosts highlights bright spots in an often challenging industry.We cover:

Venture capital in healthcare has evolved from "the trailer park of venture investing" to a fundamental core tenant of the ecosystem, reflecting a quarter-century transformation of the entire industry.In this episode, we sit down with Mohamad Makhzoumi, co-CEO of NEA, who shares his 25-year journey from unpaid intern to leader of one of the largest healthcare investment funds, offering his insights into the evolution of healthcare startups and VC.We cover:

One in four Americans relies on Medicaid, yet the program faces billions in federal funding cuts.In this episode, we speak with Dr. Rajaie Batniji, co-founder and CEO of Waymark, about delivering tech-enabled community care to Medicaid patients.We discuss what cuts to Medicaid could mean, the impact of "value veneers", and how predictive algorithms can overcome bias in healthcare delivery. Dr. Batniji also shares his personal connection to healthcare equity and his motivation for serving vulnerable populations despite investor skepticism about Medicaid-focused businesses.We cover:

In 2020, telemedicine company Teladoc acquired remote patient monitoring company Livongo for a record $18.5 billion, creating a $38 billion entity. Today, the combined company is worth less than a tenth of that.Rebecca Mitchell, who spent years as a product leader at both companies, reveals how this landmark healthcare deal fell short of expectations despite strong underlying products, and what we can learn from it.We also get her insights on the need for physician innovators, and how she came to co-found Scrub Capital.We cover:

Startup capital accelerator and venture capital firm Y Combinator has a long history of backing healthcare startups, with a particular focus on technical founders tackling difficult problems. In this episode, YC partners Jared Friedman and Ankit Gupta share their insights on healthcare investment, the transformative potential of AI, and why they believe young, tactical founders will continue to disrupt the healthcare industry despite its challenges.We cover: