Podcasts about elios

And my mom on motorcycles?! And despite what David says, Elios is horrendous!!

In this episode, Professor Ike Ahmed welcomes Dr. Ticiana de Francesco, Dr. Nathan Radcliffe, and Dr. Mark Gallardo to discuss goal setting in interventional glaucoma care. They emphasize the importance of aligning treatment strategies with patient expectations, focusing on disease control while aiming to reduce or eliminate medication use.  They introduce a practical tool to support goal setting, which can be downloaded at https://eliosvision.com/ous/resources/.   Elios Vision GmbH is the EU distributor of ELIOS manufactured by MLase GmbH, located at 82110 Germering, Industriestr. 17 Germany, and the FIDO laser applicator manufactured by WEINERT Fiber Optics GmbH, Mittlere-Motsch-Strasse 26, 96515 Sonneberg, Germany. ELIOS is CE marked and licensed for use in the EU in adult patients with glaucoma and is currently under investigational use in the US as part of an ongoing IDE study (FDA). Product feedback should be sent to productsurveillance@eliosvision.com.

In this second episode of a special two-part series on the Interventional Glaucoma Podcast, host Gok Ratnarajan is joined by Anselm Juenemann, Dan Lindfield, Jose Belda, and Nils Loewen to share insights from their first 100 ELIOS cases. They discuss patient selection, technique, and post-op management, while also exploring strategies to reduce the learning curve.  The conversation covers the safety and efficacy of ELIOS, and how to manage medications post-op for the best outcomes. The experts highlight the importance of clinical experience in achieving reliable results and provide valuable tips for glaucoma surgeons.  

“Tutte le cose sono nate da un solo fuoco” affermano i frammenti degli Oracoli caldaici. Elios, Ἠλιος in greco omerico, è il dio del Sole, spesso raffigurato con una corona raggiante, che guida un carro trainato da cavalli nel cielo. Nell'alto del cielo, Elios tutto osserva e tutto conosce, persino il ratto di Persefone non riesce a celarsi al suo sguardo onnisciente.Come scrive Macrobio nei Saturnali: “Se il Sole, secondo l'opinione degli antichi, detiene e governa tutte le altre stelle e le presiede solo nel movimento dei pianeti, e se è vero che le stelle con le loro orbite regolano l'ordine degli eventi umani, dobbiamo necessariamente considerare il Sole come supremo governatore del nostro destino: l'origine di tutto ciò che accade intorno a noi.”In effetti, senza lo splendore della danza del Sole, non solo non ci sarebbe luce per il nostro pianeta, ma non si sarebbe nemmeno potuto formare il sistema solare. Il Sole è al centro della nostra esperienza del ritmo dell'esistenza. Distingue il giorno della notte, porta a maturazione i frutti della terra, controlla il ciclo delle stagioni, contribuisce al ciclo dell'acqua. Possiamo affermare con certezza che tutto quello che accade sul pianeta Terra dipende dalla sua posizione rispetto alla stella che noi chiamiamo Sole.Ti invito a guardare il trailer del mio film Spring of a Dancer e a leggere il mio nuovo libro Primavera di un danzatore su Amazon Libri. 

In this first episode of the special two-episode series of the Interventional Glaucoma podcast, host Gok Ratnarajan is joined by esteemed guests Anselm Juenemann, Dan Lindfield, Jose Belda, and Nils Loewen to discuss key insights from their first 100 Elios cases. They share expert tips on technique, patient selection, and post-op management while exploring strategies to reduce the Elios learning curve. The conversation also delves into the safety and efficacy of the procedure and its impact on patient quality of life.

Bad service is a brand killer. This is a controversial piece today, because I am singling out one race, one group in isolation.  It is also a total generalisation and there will be exceptions where what I am saying is absolute rubbish.  There will be other races and groups, who are equally guilty as well, who I am not singling out or covering, so I am demonstrating a blatant and singular bias. I know all that, but let the hellfire rain down on my head, I am just sick of some of this lousy service here in Tokyo.  It is a mystery to me how the service in some Chinese restaurants here can be so oblivious to Japanese standards of omotenashi.  Omotenashi is that sublime combination of anticipating and exceeding client's expectations, that has made Japanese service so famous.  I love Chinese cuisine and I enjoy the high quality standard of Chinese food in Japan.  They have the best, most expensive quality, very safe ingredients and really great Chinese chefs here. When I go to places in Tokyo like Akasaka Shisen Hanten in Hirakawacho the service is very, very good.  My observation is that is probably the case because the serving staff are Japanese or Chinese who have grown up here.  Whenever I go to some “all Chinese” affairs, with only Chinese staff, I find the service is disappointing.  I had this experience again recently in the Azabu Juban.  It was a first and last time to go to this particular restaurant. The food taste wasn't the issue, in fact some dishes were delicious.  It was the total disinterest on the part of the serving staff and their manager.  You don't feel any particular need to go back there, when there are a hundred other restaurants within a two-minute walk.  This makes no sense to me, because when I am Singapore, Hong Kong or Taiwan, the restaurant service is usually very good.  Obviously, the more expensive the restaurant, the better the service of course. So, there is nothing inherently missing in the service mentality and capability, that couldn't be applied in Japan.  Why then is it so lacking in omotenashi? I remember reading a purported Chinese saying that, “A man who cannot smile, should not open a shop”.  Obviously, some of the Chinese staff working in these establishments I am complaining about, have never heard of that piece of ancient Chinese wisdom.  Smiling, making you feel welcome, treating you well are a big fat zero in my experience.  The way of serving is very perfunctory, even rough, in some cases. Japanese style restaurant table service is generally very much more refined.  What is driving this difference and what does it mean for the rest of us in the service business? Perhaps some of the Chinese staff we are seeing serving in Japan are students. According to the media reports, many are actually working almost full time.  They are not professionally trained service staff, in the sense that this is their career.  Coming from certain parts of China and from different socio-economic backgrounds, they may have had no exposure to what good levels of service looks like.  I went to China for the first time in January 1976 and have been back a number of times over the years.  I studied Chinese language, history and politics at Griffith University's Modern Asian studies faculty. I like many aspects of Chinese culture and studied Tai Qi Quan for about ten years with my excellent teacher, Cordia Chu in Brisbane, before I moved back to Japan.  I haven't been back to China for a while, but I don't recall the service being particularly bad when I was there last.  Perhaps some of these local serving staff living here in Japan only ever eat Chinese food, so they are never exposed to how Japanese restaurants serve their clients. I find that hard to believe though. The thing that puzzles me most is that despite the fact these Chinese staff are working in Japan and are floating in a deep ocean of omotenashi, some don't seem to picking up any ideas on how to treat their clients.  Why would that be?  The managers are also Chinese, so they are responsible for leading their staff in the restaurants.  Are they oblivious to the service market in Japan and how it functions?  Are they just poor managers, who cannot place their operation in a broader context of local service standards.  Are they inflexible and incapable of understanding the lifetime value of a repeater client?  This is a very competitive restaurant scene here, has more Michelin starred restaurants than Paris, so you would expect that everyone, including some of these Chinese run establishments, would be doing everything they can to build a loyal, repeater client base. This challenges me to consider what we are doing in our own case, with our customer facing service.  If I am going to bag some of the Chinese restaurant's service here in Tokyo, then I had better consider our own standards at the same time. We are a gaishikei or foreign run establishment here.  I am not Japanese, but I am the boss.  Am I operating the company service provision in terms of what I am used to in Australia, my home country?  Am I doing an Australian version of what some of these Chinese restaurants are doing here in Tokyo in their service business?  Are we in fact, providing enough omotenashi service to our own clients? Could we do better in this regard? I find a lot of Japanese service very polite, but also rather impersonal and almost robotic sometimes.  Compared to the poorer versions of some of these Chinese restaurant service offerings however, I will take the Japanese polite, impersonal, robotic option every time. How can we see our service businesses in a different light?  How can we make sure we are not only providing omotenashi levels of service, but are going beyond that, to offer a more personalised experience? Maybe we need to audit what we are doing, to see if we are missing some vital areas for improvement. I really like Elios Locanda Italian restaurant in Hanzomon, because I am treated like one of the family.  This is the feeling transmitted through their Japanese staff. Elio himself, is not always there, all the time, but that authentic Italian family style service is there.  He is setting the service standard and the Japanese staff are following it.  I see this example and I think to myself, “it is possible to have a more personal level of service here, transmitted through your Japanese staff”.  My family and I have been regulars at Elios since we returned to Tokyo from Osaka in 2001. Talk about the repeater, life time value of the customer.  They have seen my son grow from a baby, to a young man in that time.  We are part of the family and this is the key - we were made to feel like that from Day One. How about your service provision standards?  Are you making your clients feel like part of the family?  What is your repeater rate?  How many people continue to buy from you, year after year? Are you tracking this?  Do you know what the average buying continuity rate is with your customers? When we see bad service, it is always a good reminder to make sure that what we are doing ourselves is at the required omotenashi level.  If you are not sure what I am talking about with this omotenashi thing, here is my recommendation. Go to a very upscale Japanese kaiseki restaurant preferably in Kyoto or a Toraiya traditional sweets shop and remind yourself what excellent service looks like. Then reflect on what you are offering in service terms. Break down your every touch point with your customers and clients and see if there isn't a lot more omotenashi that can be introduced in each case.  We can always learn from our own mistakes and from the mistakes of others when it comes to providing better service.  The point is to observe carefully, change quickly and commit to massive improvement.

In this episode of the Interventional Glaucoma podcast, Prof. Ike Ahmed presents a series of ELIOS case studies recorded by Dr. Ana Miguel, Dr. Jose Belda, Dr. Karl Mercieca, and Ms. Nishani Amerasinghe. The cases explore the versatility of the ELIOS procedure in managing glaucoma, from early intervention in ocular hypertension to addressing complex cases with prior MIGS treatments.   Elios Vision GmbH is the EU distributor of ELIOS manufactured by MLase GmbH, located at 82110 Germering, Industriestr. 17 Germany, and the FIDO laser applicator manufactured by WEINERT Fiber Optics GmbH, Mittlere-Motsch-Strasse 26, 96515 Sonneberg, Germany. ELIOS is CE marked and licensed for use in the EU in adult patients with glaucoma and is currently under investigational use in the US as part of an ongoing IDE study (FDA). Product feedback should be sent to productsurveillance@eliosvision.com.

Generally speaking, we mainly have failures of follow up in B2B sales.  The conduct of the sale's meeting is normally done professionally.  Perhaps the salesperson could have asked better questions or presented the application of the benefits of the solution better. Maybe they could have dealt more professionally with objections or closed the deal more effectively.  In B2C though, the troubles start from the point of contact.  Getting this wrong means no meeting, let alone no sale. I blame the managers for these issues.  If they were doing their job properly, then there wouldn't be these customer facing problems.  We are salespeople and we are also buyers.  We go shopping, we eat out, we buy lots of stuff in the face to face environment.  Maybe not as much as before, because of Covid-19, but we still we do engage in some B2C activities.  When the whole hospitality industry is on its knees, you expect that those survivors still operating, are really maximising their opportunities to build their clientele. Imagine my surprise when I called a restaurant in Midtown for a lunchtime booking and bumped into some idiocy that flies in the face of the current reality.  It was around 11.31am and I was calling to make a booking for a 12.00 luncheon.  The staff member who answered the phone told me that all bookings for lunch close at 11.30am.  I could just show up at 12.00 and take my chances with the rest of the punters. It is 11.31am when we are having this conversation.  I asked him does that mean I should book at another restaurant instead of his.  There are tons of restaurants in Midtown by the way. Irony and sarcasm aren't really features of the Japanese language, so my obtuse point went straight over his head. He had been told that bookings for lunch close at 11.30am and that was that.  The idea that we are in the middle of a pandemic and that many enterprises in his industry are closing for lack of business, would warrant additional flexibility wasn't one that had ever crossed his mind.  He couldn't connect the dots and realise that what his job depends on are customers.  It was not clear to him that every restaurant wants to build new clients and to boost the spending of their regular clients.  He is just an employee, so building the business isn't part of his work remit. Well it should be.  He could have been focused on grabbing my booking, guaranteeing two covers at lunch, rather than relying on providence to supply walk-ins off the street.  He could have made me feel special by telling me that although 11.30am is the cut off point, he would take the booking anyway and really looked forward to meeting me at 12.00, “Ask for Taro and I will take care of you”, he could have said.  How would I have felt?  Would I have become more likely to go back again in the future?  Could I become a valued customer?  The answers are obvious to me but the concept was not in his mind. By way of contrast, I like Elios in Hanzomon, which is across town for me.  I have been going there with clients and with my family, since 2001 when I came back to Tokyo from Osaka.  What is my lifetime value as a customer?  Elio certainly knows this equation and so do his staff.  That is one of the reasons why I keep coming back. So I was wondering what is the difference and the reasons are obvious.  The leadership outlook and work culture of the restaurants are different.  The bosses determine the way the staff think about the business and the customers.  So, the natural extension of this reflection is to move to self reflection.  Are my staff flexible when dealing with our clients?  Are they just following the rule book and not using their brains?  Do they feel trusted enough to take responsibility to fix an issue for a client or are they ninjas, hiding behind the rules.  As the boss, you cannot be in every client conversation, so you have to delegate client care to your team.  Let's all take another look at the culture we have created.  Are we allowing individual decision making based around a common understanding of how we think about our clients? One of the things we quickly learn as leaders is that telling people something once, almost guarantees no one will remember it.  It becomes annoying to have to keep repeating the same things over and over, but you find you have to do it.  So, it always a good practice to remind everyone about how we think about serving the client.  Explain where this aligns with the value system, the vision and the mission of the enterprise.  There has to be a symbiotic relationship between our teams and the clients. The boss determines how that plays out at every micro-interaction, every day.

In this episode of the Interventional Glaucoma podcast, professor Gus Gazzard is joined by Ms. Nishani Amerasinghe and Dr Jose Belda to discuss the concept of routine Phaco Plus. They explore the benefits, safety, and patient outcomes associated with Phaco Plus, as well as its current adoption across Europe.   Elios Vision GmbH is the EU distributor of ELIOS manufactured by MLase GmbH, located at 82110 Germering, Industriestr. 17 Germany, and the FIDO laser applicator manufactured by WEINERT Fiber Optics GmbH, Mittlere-Motsch-Strasse 26, 96515 Sonneberg, Germany. ELIOS is CE marked and licensed for use in the EU in adult patients with glaucoma and is currently under investigational use in the US as part of an ongoing IDE study (FDA). Product feedback should be sent to productsurveillance@eliosvision.com.

In this episode of the Interventional Glaucoma podcast, Dr. Karl Mercieca, Dr. Gok Ratnarajan, and Dr. Ana Miguel discuss the future of glaucoma management, emphasising the potential of minimally invasive glaucoma surgery (MIGS) to improve patients' quality of life and treatment outcomes.   Elios Vision GmbH is the EU distributor of ELIOS manufactured by MLase GmbH, located at 82110 Germering, Industriestr. 17 Germany, and the FIDO laser applicator manufactured by WEINERT Fiber Optics GmbH, Mittlere-Motsch-Strasse 26, 96515 Sonneberg, Germany. ELIOS is CE marked and licensed for use in the EU in adult patients with glaucoma and is currently under investigational use in the US as part of an ongoing IDE study (FDA). Product feedback should be sent to productsurveillance@eliosvision.com.

RDV Tech 589 – La réalité c'est des compromis – Claude, Act-One, Midjourney, iOS 18.2 & 18.4, ShoptalkAu programme :Une IA débarque dans le monde réeliOS 18.2: Apple rejoint Meta sur la modérationLes nouveautés à Shoptalk, le salon de l'eCommerceLe reste de l'actualitéLiens :

En este episodio del podcast sobre glaucoma intervencionista, los prestigiosos cirujanos españoles el Dr. José Belda, la Dra. María Isabel Canut y la Dra. Marta Ibarz se reúnen para comentar las razones que justifican la combinación rutinaria de la MIGS con la cirugía de cataratas y los beneficios que ofrece a los pacientes.   Elios Vision GmbH is the EU distributor of ELIOS manufactured by MLase GmbH, located at 82110 Germering, Industriestr. 17 Germany, and the FIDO laser applicator manufactured by WEINERT Fiber Optics GmbH, Mittlere-Motsch-Strasse 26, 96515 Sonneberg, Germany. ELIOS is CE marked and licensed for use in the EU in adult patients with glaucoma and is currently under investigational use in the US as part of an ongoing IDE study (FDA). Product feedback should be sent to productsurveillance@eliosvision.com.

In this episode of the Interventional Glaucoma podcast, Professor Gus Gazzard welcomes Professor Christophe Baudouin, Mr Gok Ratnarajan and Dr Ana Miguel to discuss the impact of glaucoma treatments on patients' quality of life, emphasising the benefits of minimally invasive glaucoma surgeries (MIGS) in reducing reliance on eye drops and improving overall patient well-being.   Elios Vision GmbH is the EU distributor of ELIOS manufactured by MLase GmbH, located at 82110 Germering, Industriestr. 17 Germany, and the FIDO laser applicator manufactured by WEINERT Fiber Optics GmbH, Mittlere-Motsch-Strasse 26, 96515 Sonneberg, Germany. ELIOS is CE marked and licensed for use in the EU in adult patients with glaucoma and is currently under investigational use in the US as part of an ongoing IDE study (FDA). Product feedback should be sent to productsurveillance@eliosvision.com.

In this episode of the Interventional Glaucoma podcast, Dr. Cathy McCabe, Dr. Mark Gallardo and Mr. Dan Lindfield delve into the post-operative care and expectations following the Elios procedure, highlighting the similarities to routine cataract surgery and long-term outcomes in IOP and medication reduction.   Elios Vision GmbH is the EU distributor of ELIOS manufactured by MLase GmbH, located at 82110 Germering, Industriestr. 17 Germany, and the FIDO laser applicator manufactured by WEINERT Fiber Optics GmbH, Mittlere-Motsch-Strasse 26, 96515 Sonneberg, Germany. ELIOS is CE marked and licensed for use in the EU in adult patients with glaucoma and is currently under investigational use in the US as part of an ongoing IDE study (FDA). Product feedback should be sent to productsurveillance@eliosvision.com.

In this episode of the Interventional Glaucoma podcast, Dr. Cathy McCabe hosts a discussion with Dr. Mark Gallardo and Mr. Dan Lindfield about intra-operative pearls for the Elios procedure. They delve into the nuances of patient positioning, visualization techniques and probe handling, offering practical insights and tips for surgeons considering adopting this innovative technology.     Elios Vision GmbH is the EU distributor of ELIOS manufactured by MLase GmbH, located at 82110 Germering, Industriestr. 17 Germany, and the FIDO laser applicator manufactured by WEINERT Fiber Optics GmbH, Mittlere-Motsch-Strasse 26, 96515 Sonneberg, Germany. ELIOS is CE marked and licensed for use in the EU in adult patients with glaucoma and is currently under investigational use in the US as part of an ongoing IDE study (FDA). Product feedback should be sent to productsurveillance@eliosvision.com.

In this episode of the Interventional Glaucoma podcast, host Dr. Cathy McCabe is joined by Dr. Mark Gallardo and Mr. Dan Lindfield to explore Elios, a minimally invasive and precise solution for patients with cataracts and glaucoma. The conversation delves into patient selection criteria, effective communication strategies, and the need for a shift towards holistic patient-centered care.   Elios Vision GmbH is the EU distributor of ELIOS manufactured by MLase GmbH, located at 82110 Germering, Industriestr. 17 Germany, and the FIDO laser applicator manufactured by WEINERT Fiber Optics GmbH, Mittlere-Motsch-Strasse 26, 96515 Sonneberg, Germany. ELIOS is CE marked and licensed for use in the EU in adult patients with glaucoma and is currently under investigational use in the US as part of an ongoing IDE study (FDA). Product feedback should be sent to productsurveillance@eliosvision.com.

David Gritz joins the show again, this time solo, to share some of the important themes he and his InsurTech NY co-founder, Tony Lew, are making the center of their 2024 Spring Conference. Those themes, AI and Analytics, are each powerful and important in their own right, but the interplay of the two is exponentially more impactful for the future of the insurance industry. The Spring Conference will again focus on practical and impactful applications of AI and Analytics from across P&C, Life and Benefits, with speakers and panelists from across the industry, as well as outstanding networking opportunities. Highlights from the Show InsurTech NY is an ecosystem that acts as an international gateway for startups, brokers, investors and insurers to come together to make the world more resilient through insurance solutions David's experience with an insurtech startup is told in The Future of Insurance, Volume III. The Collaborators March 20th and 21st is the InsurTech NY Spring Conference at Chelsea Piers in NYC, with this year's themes being AI & Analytics and how they can improve underwriting, claims outcomes and more They try to make the content practical so people can walk away with ideas about implementation and impact, with thoughts like how AI can make you more efficient, which can allow your people to dig into the things that take more expertise and therefore drive better results The framing for the event is focused on some key questions Will AI stick in the industry? If so, what kinds of AI and applications are likely to be more than just buzz? How can Analytics help with the highly volatile state of the world today, and the way volatility in different areas is so intertwined, like labor, inflation, war and climate risks? How does AI coming together with Analytics change things? They have a startup in their accelerator called Salient looking at this type of question precisely ITNY also has launched a VC Fund, and are launching their second fund now, with a few areas of focus The growth of Excess & Surplus (E&S) lines as a way for startups to serve a niche that existing players can't serve effectively today A portfolio company, Sertis, focuses on multi-family property risks and combine insurance with a tool to drive better property management and upkeep to reduce losses and rates Reducing the friction in insurance transactions, which is a broad theme A portfolio company, BirdsEyeView, combines all the tools an underwriter needs in one screen to make it easier to take in underwriting inputs from different sources like weather tools smoother and faster Increasing the availability of coverage to more parts of the market to make the world more resilient Elios, who makes disability insurance easier to buy, helping to solve for the extremely low penetration rates of the coverage (only 14% in the US, and just 5% in the UK) The second day Keynote is a panel around startups getting to profitability, with three major insurtech CEOs on stage Jack Kudale, CEO and co-founder of Cowbell Cyber Alex Timms, CEO and founder of Root Insurance Rick McCathron, CEO of Hippo You can get more information and tickets to the ITNY Spring Conference at insurtechny.com This episode is brought to you by The Future of Insurance book series (future-of-insurance.com) from Bryan Falchuk. Follow the podcast at future-of-insurance.com/podcast for more details and other episodes. Music courtesy of Hyperbeat Music, available to stream or download on Spotify, Apple Music, and Amazon Music and more.

Eddig 186 bejelentést kapott az Integritás Hatóság, ezek alapján jelenleg 21 vizsgálat van folyamatban, összesen 120 milliárd forint értékű uniós támogatást érintően – mondta a Dellában Biró Ferenc, a szervezet elnöke. Ezek között vannak „szenzitívebb” ügyek is, de például az Elios-botrányt – amely Tiborcz Istvánhoz köthető – hiába keresnénk köztük, mert bár erre vonatkozóan is kaptak bejelentést, de a vizsgálat elindítását sem tartották szükségesnek. Az egyik legnagyobb problémának mégis azt tartja az elnök, hogy végül a köz pénzéből, tehát az állami költségvetésből fizetnek ki olyan beruházásokat, amelyeket eredetileg uniós finanszírozásból terveztek megvalósítani, csak a piros lámpa kigyulladt Brüsszelben.

Három ábra arról, mennyire nincs pénzünk bármit is vásárolni G7     2023-12-06 15:05:09     Gazdaság Szlovénia Az extrémen bukó Szlovénián kívül a magyar kiskereskedelmi forgalom csökken a legjobban, és más országokkal szemben nálunk a fordulatnak sincs még jele. A Pest Vármegyei Kormányhivatal visszavonta a Pázmány Campus miatt kiadott bontási engedélyeket Telex     2023-12-06 14:04:19     Belföld Vármegye Józsefváros Az építészeti hatóság korrigálta magát. Figyelembe kellett volna vennie, hogy Józsefváros védelem alá helyezte a bontásra ítélt épületeket. Állami szerv akar új vagyonnyilatkozati rendszert 24.hu     2023-12-06 11:07:29     Gazdaság Vagyonnyilatkozat Elios-ügy Politikailag szenzitívebb ügyeket is vizsgál a szervezet, de a Tiborcz Istvánhoz köthető Elios-ügy nincs közöttük. Della podcast Biró Ferenccel, a hatóság elnökével. 10 százalék alá szorított infláció? Reagált a KSH Forbes     2023-12-06 11:12:01     Gazdaság Infláció KSH Fogyasztás A szakértők szerint régi módszertannal és a tényleges fogyasztással súlyozva lehetetlen lett volna az egy számjegyű infláció. A KSH úgy értékeli, hogy ők transzparensen kommunikáltak, és szerintük a média rivaldafénye is tehetett a felháborodásról. Vasútbezárás felsőfokon: a MÁV már vonathelyettesítő autóbuszokat is megszüntet 444.hu     2023-12-06 14:34:07     Autó-motor Közlekedés MÁV Zrt. Egyre kevesebb az esély, hogy a nyáron bezárt 10 vasúti mellékvonalon valaha visszaáll a vasúti közlekedés. Teljesen átalakítanák a MÁV és a Volán jegyeit és bérleteit: a kormány előtt Lázár János javaslata – még ma döntés születhet vg.hu     2023-12-06 14:10:58     Belföld Közlekedés MÁV Zrt. Lázár János Volánbusz Úgy tűnik, elérkezett az idő, hogy alapjaiban megújítsák az állami közösségi közlekedés jegykínálatát. A cél, hogy a mintegy százfajta díjtípusból csak néhány maradjon. Ebből baj lesz: Joe Biden történelmi mélypontra kerülhetett Privátbankár     2023-12-06 15:06:07     Külföld USA Joe Biden December az amerikai politika szempontjából is jelentősnek bizonyult, ugyanis most jutottunk el arra a pontra, hogy kevesebb, mint egy év van hátra addig, míg választásokat rendeznek az Egyesült Államokban. A lecke tehát fel van adva Joe Bidennek – de mennyivel áll jobban vagy rosszabbul, mint elődei? Rosszabb a magyar tej, mint a külföldi? Ez igaz, vagy csak üzleti fogás? Agroinform     2023-12-06 14:38:57     Állatvilág Gazdaság Mezőgazdaság Tej A tejfeldolgozók előszeretettel reklamálnak a nyerstej beltartalmi értékei miatt, holott a magyar tej nem rosszabb, mint a külföldi. Ha pedig még jobbat szeretnének, akkor azt meg kellene fizetni. Ki miatt szerepel gyengén a Fradi? HírTV     2023-12-06 10:33:00     Foci Magyar foci Szerbia NB I FTC Dejan Sztankovics Több mint egy hónapja nyeretlen a magyar labdarúgó-bajnokságban (NB I) a Ferencváros. Az új edző, Dejan Sztankovics először került hullámvölgybe, a szurkolókat pedig alaposan megosztja a szerb tréner. Súlyos vereséget szenvedhet Amerika a kulcsfontosságú térségben – Hasonló cipőben járnak, mint az oroszok Portfolio     2023-12-06 10:34:00     Külföld USA Izrael Palesztina Hamász Gázai övezet Egyiptom Cipő Az Egyesült Államok aktívan támogatja Izraelt a Hamász elleni küzdelmei során, ezzel tapasztalhatóan újra aktív részese a közel-keleti események alakulásának. Az amerikai külpolitika egyre nagyobb kihívás elé néz a Gázai övezet kérdésében, mivel az arab világ egyre rosszallóbban tekint a Fehér Ház politikájára – nyilatkozta a volt egyiptomi külügym Háborút indítanak az apácák: beperlik a legnagyobb amerikai fegyvergyártót Noizz     2023-12-06 15:39:08     Bulvár USA háború Katolikus Katolikus apácák keresetet nyújtottak be a Smith & Wesson, az Amerikai Egyesült Államok legnagyobb kézifegyvegyártója ellen, mert a vállalat nem reagált a tömeges lövöldözésekkel kapcsolatos perekre, ezzel megsértették a szövetségi törvényeket. Heteken át hajózott, de csak a magyarokkal játszhatott az első ázsiai vb-résztvevő Büntető.com     2023-12-06 13:04:11     Foci Hollandia India Indonézia Hollandiának köszönhette a labdarúgást a mai Indonézia, amely a gyarmati időkben még a Holland Kelet-India nevet viselte, de a labdarúgáson keresztül is harcolt a gyarmatosítói ellen. A Real Madrid kiválósága nem utazik az Eb-re sajtóhír Sportal     2023-12-06 14:29:06     Foci Spanyolország Belgium Real Madrid A Radio Marca értesülései szerint Thibaut Courtois nem lesz ott az Európa-bajnokságon a belga válogatottal. Havat hozott a Mikulás: vastag hótakaró borítja a tájat a nyugati országrészben Kiderül     2023-12-06 17:35:34     Időjárás Duna Mikulás Havazás Bakony Jelentős mennyiségű hó hullott a Dunántúlon és a Duna vonalában szerdán, éjfélig 20 centinél is vastagabb lehet a hóréteg a Bakonyban. A havazás az ország keleti tájaira is érkezik.

Három ábra arról, mennyire nincs pénzünk bármit is vásárolni G7     2023-12-06 15:05:09     Gazdaság Szlovénia Az extrémen bukó Szlovénián kívül a magyar kiskereskedelmi forgalom csökken a legjobban, és más országokkal szemben nálunk a fordulatnak sincs még jele. A Pest Vármegyei Kormányhivatal visszavonta a Pázmány Campus miatt kiadott bontási engedélyeket Telex     2023-12-06 14:04:19     Belföld Vármegye Józsefváros Az építészeti hatóság korrigálta magát. Figyelembe kellett volna vennie, hogy Józsefváros védelem alá helyezte a bontásra ítélt épületeket. Állami szerv akar új vagyonnyilatkozati rendszert 24.hu     2023-12-06 11:07:29     Gazdaság Vagyonnyilatkozat Elios-ügy Politikailag szenzitívebb ügyeket is vizsgál a szervezet, de a Tiborcz Istvánhoz köthető Elios-ügy nincs közöttük. Della podcast Biró Ferenccel, a hatóság elnökével. 10 százalék alá szorított infláció? Reagált a KSH Forbes     2023-12-06 11:12:01     Gazdaság Infláció KSH Fogyasztás A szakértők szerint régi módszertannal és a tényleges fogyasztással súlyozva lehetetlen lett volna az egy számjegyű infláció. A KSH úgy értékeli, hogy ők transzparensen kommunikáltak, és szerintük a média rivaldafénye is tehetett a felháborodásról. Vasútbezárás felsőfokon: a MÁV már vonathelyettesítő autóbuszokat is megszüntet 444.hu     2023-12-06 14:34:07     Autó-motor Közlekedés MÁV Zrt. Egyre kevesebb az esély, hogy a nyáron bezárt 10 vasúti mellékvonalon valaha visszaáll a vasúti közlekedés. Teljesen átalakítanák a MÁV és a Volán jegyeit és bérleteit: a kormány előtt Lázár János javaslata – még ma döntés születhet vg.hu     2023-12-06 14:10:58     Belföld Közlekedés MÁV Zrt. Lázár János Volánbusz Úgy tűnik, elérkezett az idő, hogy alapjaiban megújítsák az állami közösségi közlekedés jegykínálatát. A cél, hogy a mintegy százfajta díjtípusból csak néhány maradjon. Ebből baj lesz: Joe Biden történelmi mélypontra kerülhetett Privátbankár     2023-12-06 15:06:07     Külföld USA Joe Biden December az amerikai politika szempontjából is jelentősnek bizonyult, ugyanis most jutottunk el arra a pontra, hogy kevesebb, mint egy év van hátra addig, míg választásokat rendeznek az Egyesült Államokban. A lecke tehát fel van adva Joe Bidennek – de mennyivel áll jobban vagy rosszabbul, mint elődei? Rosszabb a magyar tej, mint a külföldi? Ez igaz, vagy csak üzleti fogás? Agroinform     2023-12-06 14:38:57     Állatvilág Gazdaság Mezőgazdaság Tej A tejfeldolgozók előszeretettel reklamálnak a nyerstej beltartalmi értékei miatt, holott a magyar tej nem rosszabb, mint a külföldi. Ha pedig még jobbat szeretnének, akkor azt meg kellene fizetni. Ki miatt szerepel gyengén a Fradi? HírTV     2023-12-06 10:33:00     Foci Magyar foci Szerbia NB I FTC Dejan Sztankovics Több mint egy hónapja nyeretlen a magyar labdarúgó-bajnokságban (NB I) a Ferencváros. Az új edző, Dejan Sztankovics először került hullámvölgybe, a szurkolókat pedig alaposan megosztja a szerb tréner. Súlyos vereséget szenvedhet Amerika a kulcsfontosságú térségben – Hasonló cipőben járnak, mint az oroszok Portfolio     2023-12-06 10:34:00     Külföld USA Izrael Palesztina Hamász Gázai övezet Egyiptom Cipő Az Egyesült Államok aktívan támogatja Izraelt a Hamász elleni küzdelmei során, ezzel tapasztalhatóan újra aktív részese a közel-keleti események alakulásának. Az amerikai külpolitika egyre nagyobb kihívás elé néz a Gázai övezet kérdésében, mivel az arab világ egyre rosszallóbban tekint a Fehér Ház politikájára – nyilatkozta a volt egyiptomi külügym Háborút indítanak az apácák: beperlik a legnagyobb amerikai fegyvergyártót Noizz     2023-12-06 15:39:08     Bulvár USA háború Katolikus Katolikus apácák keresetet nyújtottak be a Smith & Wesson, az Amerikai Egyesült Államok legnagyobb kézifegyvegyártója ellen, mert a vállalat nem reagált a tömeges lövöldözésekkel kapcsolatos perekre, ezzel megsértették a szövetségi törvényeket. Heteken át hajózott, de csak a magyarokkal játszhatott az első ázsiai vb-résztvevő Büntető.com     2023-12-06 13:04:11     Foci Hollandia India Indonézia Hollandiának köszönhette a labdarúgást a mai Indonézia, amely a gyarmati időkben még a Holland Kelet-India nevet viselte, de a labdarúgáson keresztül is harcolt a gyarmatosítói ellen. A Real Madrid kiválósága nem utazik az Eb-re sajtóhír Sportal     2023-12-06 14:29:06     Foci Spanyolország Belgium Real Madrid A Radio Marca értesülései szerint Thibaut Courtois nem lesz ott az Európa-bajnokságon a belga válogatottal. Havat hozott a Mikulás: vastag hótakaró borítja a tájat a nyugati országrészben Kiderül     2023-12-06 17:35:34     Időjárás Duna Mikulás Havazás Bakony Jelentős mennyiségű hó hullott a Dunántúlon és a Duna vonalában szerdán, éjfélig 20 centinél is vastagabb lehet a hóréteg a Bakonyban. A havazás az ország keleti tájaira is érkezik.

Emission en direct Chaque mercredi à 19:00 sur YouTube :Les nouvelles de du monde de la six cordes et la réponses à vos questions en direct ! Replay FAQ du 29/11/23 Sujets abordés Podcast de La Chaîne Guitare La version audio de la vidéo est disponible dans le podcast de La Chaîne Guitare (sur iTunes, L'article FAQ – Saturne Hypérion Boissières, Elios & Boulou Ferré, Guitar Fest est apparu en premier sur La Chaîne Guitare.

durée : 00:59:23 - Boulou & Elios Ferré - par : Alex Dutilh - Héritiers d'une fratrie de guitaristes qui furent les compagnons de route de Django Reinhardt et se distinguèrent dans les années 30 et 40 comme les créateurs de la valse swing, Boulou & Elios Ferré ont décidé de rendre hommage à leur père Matelo et à leurs oncles, Baro et Sarane.

durée : 00:59:23 - Boulou & Elios Ferré - par : Alex Dutilh - Héritiers d'une fratrie de guitaristes qui furent les compagnons de route de Django Reinhardt et se distinguèrent dans les années 30 et 40 comme les créateurs de la valse swing, Boulou & Elios Ferré ont décidé de rendre hommage à leur père Matelo et à leurs oncles, Baro et Sarane.

Les aventures de C'est Dispo à l'extérieur du magasin nous amènent aujourd'hui à Labège au Yankee Grill pour vous présenter de redoutables nouveaux jeux de société ______________________________________

En este nuevo episodio, continuamos explorando la mitología griega, y nos adentramos en el nacimiento de algunos de los seres más oscuros de la mitología, conoceremos a la familia de la noche, donde muchos de sus hijos e hijas traen consigo la oscuridad y la desesperación. Descubrimos a la diosa Noche y sus múltiples descendientes, algunos de los cuales son figuras perturbadoras como la perdición, la culpa, la angustia, y la muerte. Pero no todo es sombrío, también resaltamos las figuras que emergieron del caos con una luz positiva. En particular, el amable Nereo que nació del mar, y las hermosas Nereidas, hijas de Nereo y una hija del océano. También descubrimos las historias de personajes fascinantes como Medusa, Quimera y la enigmática Esfinge. Además, destacamos el linaje de deidades celestiales como Elios, Selene y Eos. Prepárate para sumergirte en el mundo lleno de dioses que emergieron en el inicio del universo según la mitología griega.Recuerda, puedes encontrar las referencias y fuentes utilizadas en nuestra página web del podcast para profundizar aún más en estos mitos y leyendas.La web del podcast: https://www.mitosymas.com/ Síguenos en las redes sociales:Facebook: https://www.facebook.com/demit... Twitter: https://www.twitter.com/mitosY... Instagram: https://www.instagram.com/mito...

Nuestro siguiente invitado es Roby Croitorescu Weber, sobreviviente del Holocausto, nació un 20 de septiembre de 1943 en un campo de concentración en Transnistira. Hijo de Isaac (1910-1994) originario de Vaslui, Rumanía y Dora (1914-1998), nacida en Radautz, Bukovina.  En verano de 1948, tras haber sido liberados por los rusos y vivido en Transilvania, emigran a Eretz Israel. Fueron años muy duros hasta que logró estabilizarse y montar una óptica en Tel- Aviv, Óptica Stilorex. La historia toma un giro cuando Isaac decide emigrar a Venezuela. Llegan en el 58 en un avión de la línea Aeropostal desde Roma. Con un préstamo y sin firmar giros, monta la óptica Roxy.  Roby, estudia un año en el Colegio Moral y Luces y luego termina en el Americano. Su padre lo envía con un grupo de personas a Nueva York, a estudiar con un profesor que era uno de los padres de la optometría en Estados Unidos, y de ahí fue al Royal College of Science en Toronto, donde obtiene el título de optometrista. Al regresar, Isaac  compra otra óptica, Óptica Venezuela. La curiosidad de Roby lo lleva a montar un laboratorio y comienza a trabajar los cristales, y con una máquina de segunda, inicia el primer taller. Así fueron los inicios del conglomerado de Ópticas Caroní en 1976 con más de 86 sucursales por toda Venezuela. Hoy en día las familias Espín, Moreno, Fridzon y Crouturescu manejan el negocio, ya son segunda generación y tienen varias ópticas en los Estados Unidos, incluida óptica Elios en Miami. En su haber comunitario, fue presidente de Hebraica-Caracas de Venezuela, de la Unión Israelita de Caracas, de Vaad Hakehilot y Presidente de CLAM-Confederación Latinoamericana Macabi y como miembro activo de CAIV (Confederación de Asociaciones Israelita de Venezuela) concibió y concretó el sueño de conformar la primera organización encargada de capacitar a jóvenes en la defensa del Estado de Israel a través de la diplomacia pública, Hatzad Hasheni (2010). Agradece todos los días por su hermosa familia, su esposa Ghena,sus hijos, Ariel y Mery, Lili y Dan, Gila y Salomón y nueve hermosos nietos. --- Support this podcast: https://podcasters.spotify.com/pod/show/tamara-kassab/support

Homoki Andrea közösségszervező, az Elios-szerződéseket és a vonatkozó OLAF-jelentést kiperlő civil szervezet aktivistája. Stelczer Attila egy szomszédos település, Vecsés egyesületében segíti megoldani lakóhelye problémáit. A két aktivistával elrontott közvilágításról, sárgára színeződött ivóvízről, nehézkes tömegközlekedésről beszélgettünk, és arról, mit és hogyan tehet ilyen és hasonló problémák ellen – másokkal összefogva – egy hétköznapi állampolgár.

This month on Episode 42 of Discover CircRes, host Cynthia St. Hilaire highlights four original research articles featured in the October 28 and November 11th  issues of Circulation Research. This episode also features an interview with Dr Miguel Lopez-Ramirez and undergraduate student Bliss Nelson from University of California San Diego about their study, Neuroinflammation Plays a Critical Role in Cerebral Cavernous Malformations.   Article highlights:   Jia, et al. Prohibitin2 Maintains VSMC Contractile Phenotype   Rammah, et al. PPARg and Non-Canonical NOTCH Signaling in the OFT   Wang, et al. Histone Lactylation in Myocardial Infarction   Katsuki, et al. PCSK9 Promotes Vein Graft Lesion Development   Cindy St. Hilaire:        Hi, and welcome to Discover CircRes, the podcast of the American Heart Association's Journal, Circulation Research. I'm your host, Dr Cindy St. Hilaire from the Vascular Medicine Institute at the University of Pittsburgh, and today, I'm going to be highlighting articles from our October 28th and our November 11th issues of Circ Res. I'm also going to have a chat with Dr Miguel Lopez-Ramirez and undergraduate student Bliss Nelson, about their study, Neuroinflammation Plays a Critical Role in Cerebral Cavernous Malformations. But, before I get into the interviews, here are a few article highlights.   Cindy St. Hilaire:        The first article is from our October 28th issue, and the title is, PHB2 Maintains the Contractile Phenotype of Smooth Muscle Cells by Counteracting PKM Splicing. The corresponding author is Wei Kong, and the first authors are Yiting Jia and Chengfeng Mao, and they are all from Peking University. Insults to blood vessels, whether in the form of atherosclerosis, physical injury, or inflammation, can trigger vascular smooth muscle cells to transition from a contractile state to a proliferative and migratory one. Accompanying this conversion is a switch in the cells' metabolism from the mitochondria to glycolysis. But what controls this switch? To investigate, this group compared the transcriptomes of contractile and proliferative smooth muscle cells.   Among the differentially expressed genes, more than 1800 were reciprocally up and down regulated. Of those, six were associated with glucose metabolism, including one called Prohibitin-2, or PHB2, which the team showed localized to the artery wall. In cultured smooth muscle cells, suppression of PHB2 reduced expression of several contractile genes. While in rat arteries, injury caused a decrease in production of PHB2 itself, and of contractile markers.   Furthermore, expression of PHB2 in proliferative smooth muscle cells could revert these cells to a contractile phenotype. Further experiments revealed PHB2 controlled the splicing of the metabolic enzyme to up-regulate the phenotypic switch. Regardless of mechanism, the results suggest that boosting PHB2 might be a way to reduce adverse smooth muscle cell overgrowth and conditions such as atherosclerosis and restenosis.   Cindy St. Hilaire:        The second article I'm going to highlight is also from our October 28th issue, and the first authors are Mayassa Rammah and Magali Theveniau-Ruissy. And the corresponding authors are Francesca Rochais and Robert Kelly. And they are all from Marseille University. Abnormal development of the heart's outflow track, which ultimately forms the bases of the aorta and the pulmonary artery, accounts for more than 30% of all human congenital heart defects. To gain a better understanding of outflow tract development, and thus the origins of such defects, this group investigated the role of transcription factors thought to be involved in specifying the superior outflow tract, or SOFT, which gives rise to the subaortic myocardium, and the inferior outflow tract, which gives rise to the subpulmonary myocardium. Transcription factor S1 is over-expressed in superior outflow tract cells and the transcription factors, TBX1 and PPAR gamma, are expressed in inferior outflow tract cells.   And now this group has shown that TBX1 drives PPAR gamma expression in the inferior outflow tract, while Hess-1 surpasses PPAR gamma expression in the superior outflow tract. Indeed, in mouse embryos lacking TBX1, PPAR gamma expression was absent in the outflow tract. While in mouse embryos lacking Hess-1, PPAR gamma expression was increased and PPAR gamma positive cells were more widespread in the outflow tract.   The team also identified that signaling kinase DLK is an upstream activator of Hess-1 and a suppressor of PPAR gamma. In further detailing the molecular interplay regulating outflow tract patterning, the work will shed light on congenital heart disease etiologies, and inform potential interventions for future therapies.   Cindy St. Hilaire:        The third article I want to highlight is from our November 11th issue of Circulation Research, and the title is Histone Lactylation Boosts Reparative Gene Activation Post Myocardial Infarction. The first author is Jinjin Wang and the corresponding author is Maomao Zhang, and they're from Harbin Medical University. Lactylation of histones is a recently discovered epigenetic modification that regulates gene expression in a variety of biological processes. In inflammation, for example, a significant increase in histone lactylation is responsible for switching on reparative genes and macrophages when pro-inflammatory processes give way to pro-resolvin ones.   The role of histone lactylation in inflammation resolution has been shown in a variety of pathologies, but has not been examined in myocardial infarction. Wang and colleagues have now done just that. They isolated monocytes from the bone marrow and the circulation of mice at various time points after induced myocardial infarctions, and examined the cells' gene expression patterns. Within a day of myocardial infarction, monocytes from both bone marrow and the blood had begun upregulating genes involved in inflammation resolution. And, concordant with this, histone lactylation was dramatically increased in the cells, specifically at genes involved in repair processes.   The team went on to show that injection of sodium lactate into mice boosted monocyte histone lactylation and improved heart function after myocardial infarction, findings that suggest further studies of lactylation's pro-resolving benefits are warranted. Cindy St. Hilaire:        The last article I want to highlight is titled, PCSK9 Promotes Macrophage Activation via LDL Receptor Independent Mechanisms. The first authors are Shunsuke Katsuki and Prabhash Kumar Jha, and the corresponding author is Masanori Aikawa, and they are from Brigham and Women's Hospital in Harvard. Statins are the go-to drug for lowering cholesterol in atherosclerosis patients. But the more recently approved PCSK9 inhibitors also lower cholesterol and can be used to augment or replace statins in patients where these drugs are insufficient.   PCSK9 is an enzyme that circulates in the blood and destroys the LDL receptor, thereby impeding the removal of bad cholesterol. The enzyme also appears to promote inflammation, thus potentially contributing to atherosclerosis in two ways. This group now confirms that PCSK9 does indeed promote pro-inflammatory macrophage activation and lesion development, and does so independent of its actions on the LDL receptor.   The team assessed PCSK9-induced lesions in animals with saphenous vein grafts, which are commonly used in bypass surgery but are prone to lesion regrowth. They found that LDL receptor lacking graft containing mice had greater graft macrophage accumulation and lesion development when PCSK9 activity was boosted than when it was not. The animal's macrophages also had higher levels of the pro-inflammatory factor expression. Together, this work shows that PCSK9 inhibitors provide a double punch against atherosclerosis and might be effective drugs for preventing the all too common failure of saphenous vein grafts.   Cindy St. Hilaire:        So, today with me I have Dr Miguel Lopez-Ramirez and undergraduate student Bliss Nelson from the University of California in San Diego, and we're going to talk about their study, Neuroinflammation Plays a Critical Role in Cerebral Cavernous Malformation Disease, and this article is in our November 11th  issue of Circulation Research. Thank you both so much for joining me today. Before we talk about the science, want to just maybe tell me a little bit about yourselves?   Bliss Nelson:                My name is Bliss Nelson. I'm a member of Miguel Lopez-Ramirez's lab here at UC San Diego at the School of Medicine. I'm an undergraduate student here at UC San Diego. I'm actually a transfer student. I went to a community college here in California and I got involved in research after I transferred.   Cindy St. Hilaire:        What's your major?   Bliss Nelson:                I'm a cognitive science major.   Cindy St. Hilaire:        Excellent. You might be the first undergrad on the podcast, which is exciting.   Bliss Nelson:                Wow. What an honor. Thank so much.   Cindy St. Hilaire:        And Miguel, how about you?   Miguel Lopez-Ramirez: Yes, thank you. Well, first thank you very much for the opportunity to present our work through this media. It's very exciting for us. My name is Miguel Alejandro Lopez-Ramirez, and I'm an assistant professor in the Department of Medicine and Pharmacology here at UCSD. Cindy St. Hilaire:        Wonderful. I loved your paper, because, well, first, I don't think I've talked about cerebral cavernous malformations. So what are CCMs, and why are they so bad?   Bliss Nelson:                Cerebral cavernous malformations, or CCMs for short, are common neurovascular lesions caused by a loss of function mutation in one of three genes. These genes are KRIT1, or CCM1, CCM2 and PDCD10, or CCM3, and generally regarded as an endothelial cell autonomous disease found in the central nervous system, so the brain and the spinal cord.   The relevance of CCMs is that it affects about one in every 200 children and adults, and this causes a lifelong risk of chronic and acute hemorrhaging. CCMs can be quiescent or dynamic lesions. If they are dynamic, they can enlarge, regress, or behave progressively, producing repetitive hemorrhaging and exacerbations of the disease.   Other side effects of the disease could be chronic bleedings, focal neurological deficits, headaches, epileptic seizures and, in some cases, death. There's no pharmacological treatment for CCMs. There's only one type of option some patients may have, which would be to have surgery to cut out the lesions. But of course this depends on where the lesion or lesions are in the central nervous system, if that's even an option. So sometimes there's no option these patients have, there's no treatment, which is what propels our lab to towards finding a pharmacological treatment or uncovering some of the mechanisms behind that.   Cindy St. Hilaire:        Do people who have CCM know that they have them or sometimes it not detected? And when it is detected, what are the symptoms?   Bliss Nelson:                Sometimes patients who have them may not show any symptoms either ever in their lifetime or until a certain point, so really the only way to find out if you were to have them is if you went to go get a brain scan, if you went to go see a doctor, or if you started having symptoms. But also, one of the issues with CCMs is that they're very hard to diagnose, and in the medical community there's a lack of knowledge for CCMs, so sometimes you may not get directed to the right specialist in time, or even ever, and be diagnosed.   Miguel Lopez-Ramirez: I will just add a little bit. It is fabulous, what you're doing. I think this is very, very good. But yes, that's why they're considered rare disease, because it's not obvious disease, so sometimes most of the patient, they go asymptomatic even when they have one lesions, but there's still no answers of why patients that are asymptomatics can become symptomatics. And there is a lot in neuro study, this study that we will start mentioning a little bit more in detail. We try to explain these transitions from silent or, quiescent, lesion, into a more active lesion that gives the disability to the patient.   Some of the symptoms, it can start even with headaches, or, in some cases, they have more neurological deficits that could be like weakness in the arms or loss of vision. In many cases also problems with the speech or balance. So it depends where the lesion is present, in the brain or in the spinal cord, the symptoms that the patient will experience. And some of the most, I will say, severe symptoms is the hemorrhagic stroke and the vascular thrombosis and seizure that the patients can present. Those would be the most significant symptoms that the patient will experience.   Cindy St. Hilaire:        What have been some limitations in the study of CCMs? What have been limitations in trying to figure out what's going on here?   Bliss Nelson:                The limitations to the disease is that, well, one, the propensity for lesions, or the disease, to come about, isn't known, so a lot of the labs that work on it, just going down to the basic building blocks of what's even happening in the disease is a major problem, because until that's well established, it's really hard to go over to the pharmacological side of treating the disease or helping patients with the disease, without knowing what's going on at the molecular level.   Cindy St. Hilaire:        You just mentioned molecular level. Maybe let's take a step back. What's actually going on at the cellular level in CCMs? What are the major cell types that are not happy, that shift and become unhappy cells? Which are the key players?   Bliss Nelson:                That's a great question and a great part of this paper. So when we're talking about the neuroinflammation in the disease, our paper, we're reporting the interactions between the endothelium, the astrocytes, leukocytes, microglia and neutrophils, and we've actually coined this term as the CaLM interaction.   Cindy St. Hilaire:        Great name, by the way.   Bliss Nelson:                Thank you. All props to Miguel. And if you look at our paper, in figure seven we actually have a great graphic that's showing this interaction in play, showing the different components happening and the different cell types involved in the CaLM interaction that's happening within or around the CCM lesions.   Cindy St. Hilaire:        What does a astrocyte normally do? I think our podcast listening base is definitely well versed in probably endothelial and smooth muscle cell and pericyte, but not many of us, not going to lie, including me, really know what a astrocyte does. So what does that cell do and why do we care about its interaction with the endothelium?   Miguel Lopez-Ramirez: Well, the astrocytes play a very important role. Actually, there are more astrocytes than any other cells in the central nervous system, so that can tell you how important they are. Obviously play a very important role maintaining the neurological synapses, maintaining also the hemostasis of the central nervous system by supporting not only the neurons during the neural communication, but also by supporting the blood vessels of the brain.   All this is telling us that also another important role is the inflammation, or the response to damage. So in this case, what also this study proposed, is that new signature for these reactive astrocytes during cerebral malformation disease. So understanding better how the vasculature with malformations can activate the astrocytes, and how the astrocytes can contribute back to these developing of malformations. It will teach us a lot of how new therapeutic targets can be implemented for the disease.   This is part of this work, and now we extend it to see how it can also contribute to the communication with immune cells as Bliss already mentioned.   Cindy St. Hilaire:        Is it a fair analogy to say that a astrocyte is more similar to a pericyte in the periphery? Is that accurate?   Miguel Lopez-Ramirez: No, actually there are pericytes in the central nervous system as well. They have different roles. The pericyte is still a neuron cell that give the shape, plays a role in the contractility and maintains the integrity of the vessels, while the astrocyte is more like part of the immune system, but also part of the supporting of growth factors or maintaining if something leaks out of the vasculature to be able to capture that.   Cindy St. Hilaire:        You used a handful of really interesting mouse models to conduct this study. Can you tell us a little bit about, I guess, the base model for CCM and then some of the unique tools that you used to study the cells specifically?   Bliss Nelson:                Yeah, of course. I do a lot of the animal work in the lab. I'd love to tell you about the mouse model. So to this study we use the animal model with CCM3 mutation. We use this one because it is the most aggressive form of CCM and it really gives us a wide range of options to study the disease super intricately. We use tamoxifen-regulated Cre recombinase under the control of brain endothelial specific promoter, driving the silencing of the gene CCM3, which we call the PDCD10 betco animal, as you can see in our manuscript. To this, the animal without the Cre system, that does not develop any lesions, that we use as a control, we call the PDCD10 plox. And these animals are injected with the tamoxifen postnatally day one, and then for brain collection to investigate, wcollected at different stages. So we do P15, which we call the acute stage, P50, which we term the progressive stage, and then P80, which is the chronocytes stage. And after enough brain collections, we use them for histology, gene expression, RNA analysis, flow cytometry, and different imaging to help us further look into CCMs.   Cindy St. Hilaire:        How similar is a murine CCM to a human CCM? Is there really good overlap or are there some differences?   Miguel Lopez-Ramirez: Yes. So, actually, that's a very good question, and that's part of the work that we are doing. This model definitely has advantages in which the lesions of the vascular formations are in an adult and juvenile animals, which represent an advantage for the field in which now we will be able to test pharmacological therapies in a more meaningful, way where we can test different doses, different, again, approaches. But definitely, I mean, I think I cannot say that it's only one perfect model for to mimic the human disease. It's the complementary of multiple models that give us certain advantages in another, so the integration of this knowledge is what will help us to understand better the disease.   Cindy St. Hilaire:        That's great. I now want to hear a little bit about your findings, because they're really cool. So you took two approaches to study this, and the first was looking at the astrocytes and how they become these, what you're calling reactive astrocytes, and then you look specifically at the brain endothelium. So could you maybe just summarize those two big findings for us?   Miguel Lopez-Ramirez: Yeah, so, basically by doing these studies we use trangenic animal in this case that they give us the visibility to obtain the transcripts in the astrocytes. And basically this is very important because we don't need to isolate the cells, we don't need to manipulate anything, we just took all the ribosomes that were basically capturing the mRNAs and we profile those RNAs that are specifically expressed in the astrocytes.   By doing this, we actually went into looking at in depth the transcripts that were altered in the animals that developed the disease, in this case the cerebral cavernous malformation disease, and what we look at is multiple genes that were changing. Many of them were already described in our previous work, which were associated with hypoxia and angiogenesis. But what we found in this work is that now there were a lot of genes associated with inflammation and coagulation actually, which were not identified before.   What we notice is that now these astrocytes, during the initial phase of the vascular malformation, may play a more important role in angiogenesis or the degradation of the vessels. Later during the stage of the malformation, they play a more important role in the thrombosis, in the inflammation, and recruitment of leukocyte   That was a great advantage in this work by using this approach and looking in detail, these astrocytes. Also, we identified there were very important signature in these astrocytes that we refer as a reactive astrocytes with neuroinflammatory properties. In the same animals, basically, not in the same animal, but in the same basically the experimental approach, we isolated brain vasculature. And by doing the same, we actually identified not only the astrocyte but also the endothelium was quite a different pattern that we were not seeing before. And this pattern was also associated with inflammation, hypoxia and coagulation pathways.   That lead us to go into more detail of what was relevant in this vascular malformations. And one additional part that in the paper this is novel and very impactful, is that we identify inflammasome as a one important component, and particularly in those lesions that are multi-cavernous.   Now we have two different approaches. One, we see this temporality in which the lesions forms different patterns in which the initial phase maybe is more aneugenic, but as they become more progressive in chronocytes, inflammation and hypoxy pathways are more relevant for the recruitment of the inflammatory cells and also the precipitation of immunothrombosis.   But also what we notice is that inflammasome in endothelial and in the leukocytes may play an important role in the multi-cavernous formation, and that's something that we are looking in more detail, if therapeutics or also interventions in these pathways could ameliorate the transition of phases between single lesions into a more aggressive lesions.   Cindy St. Hilaire:        That's kind of one of the follow up questions I was thinking about too is, from looking at the data that you have, obviously to get a CCM, there's a physical issue in the vessel, right? It's not formed properly. Does that form influence the activation of the astrocyte, and then the astrocytes, I guess, secrete inflammatory factors, target more inflammation in the vessel? Or is there something coming from the CCM initially that's then activating the astrocyte? It's kind of a chicken and the egg question, but do you have a sense of secondary to the malformation, what is the initial trigger?   Miguel Lopez-Ramirez: The malformations in our model, and this is important in our model, definitely start by producing changes in the brain endothelial. And as you mention it, these endothelium start secreting molecules that actually directly affect the neighboring cells.   One of the first neighboring cells that at least we have identified to be affected is the astrocytes, but clearly could be also pericytes or other cells that are in the neurovascular unit or form part of the neurovascular unit. But what we have seen now is that this interaction gets extended into more robust interactions that what you were referring as the CaLM interactions.   Definitely I think during the vascular malformations maybe is the discommunication that we identify already few of those very strong iteration that is part of the follow up manuscript that we have. But also it could be the blood brain barrier breakdown and other changes in the endothelium could also trigger the activation of the astrocytes and brain cells.   Cindy St. Hilaire:        What does your data suggest about potential future therapies of CCM? I know you have a really intriguing statement or data that showed targeting NF-kappa B isn't likely going to be a good therapeutic strategy. So maybe tell us just a little bit about that, but also, what does that imply, perhaps, of what a therapeutic strategy could be?   Bliss Nelson:                Originally we did think that the inhibition of NF-kappa B would cause an improvement potentially downstream of the CCMs. And unexpectedly, to our surprise, the partial or total loss of the brain endothelial NF-kappa B activity in the chronic model of the mice, it didn't prevent or cause any improvement in the lesion genesis or neuroinflammation, but instead it resulted in a trend to increase the number of lesions and immunothrombosis, suggesting that the inhibition of it is actually worsening the disease and shouldn't be used as a target for therapeutical approaches.   Miguel Lopez-Ramirez: Yes, particularly that's also part of the work that we have ongoing in which NF-kappa B may also play a role in preventing the further increase of inflammation. So that is something that it can also be very important. And this is very particular for certain cell types. It's very little known what the NF-kappa B actually is doing in the brain endothelial during malformations or inflammation per se. So now it's telling us that this is something that we have to consider for the future.   Also, our future therapeutics of what we propose are two main therapeutic targets. One is the harmful hypoxia pathway, which involves activation, again, of the population pathway inflammation, but also the inflammasomes. So these two venues are part of our ongoing work in trying to see if we have a way to target with a more safe and basically efficient way this inflammation.   However, knowing the mechanisms of how these neuroinflammation take place is what is the key for understanding the disease. And maybe even that inflammatory and inflammatory compounds may not be the direct therapeutic approach, but by understanding these mechanisms, we may come with  new approaches that will help for safe and effective therapies.   Cindy St. Hilaire:        What was the most challenging part of this study? I'm going to guess it has something to do with the mice, but in terms of collecting the data or figure out what's going on, what was the most challenging?   Bliss Nelson:                To this, I'd like to say that I think our team is very strong. We work very well together, so I think even the most challenging part of completing this paper wasn't so challenging because we have a really strong support system among ourselves, with Miguel as a great mentor. And then there's also two postdocs in the lab who are also first authors that contributed a lot to it.   Cindy St. Hilaire:        Great. Well, I just want to commend both of you on an amazing, beautiful story. I loved a lot of the imaging in it, really well done, very technically challenging, I think, pulling out these specific sets of cells and investigating what's happening in them. Really well done study. And Bliss, as an undergraduate student, quite an impressive amount of work. And I congratulate both you and your team on such a wonderful story.   Bliss Nelson:                Thank you very much.   Miguel Lopez-Ramirez: Thank you for Bliss and also Elios and Edo and Katrine, who all contributed      enormously to the completion of this project.   Cindy St. Hilaire:        It always takes a team.   Miguel Lopez-Ramirez: Yes.   Cindy St. Hilaire:        Great. Well, thank you so much, and I can't wait to see what's next for this story.   Cindy St. Hilaire:        That's it for the highlights from October 28th and November 11th issues of Circulation Research. Thank you so much for listening. Please check out the Circ Res Facebook page and follow us on Twitter and Instagram with the handle @circres and #discovercircres. Thank you to our guests, Dr Miguel Lopez-Ramirez and Bliss Nelson. This podcast is produced by Ashara Retniyaka, edited by Melissa Stoner, and supported by the editorial team of Circulation Research. Some of the copy text for our highlighted articles is provided by Ruth Williams. I'm your host, Dr Cindy St. Hilaire, and this is Discover CircRes, you're on the go source for the most exciting discoveries in basic cardiovascular research. This program is copyright of the American Heart Association 2022. The opinions expressed by speakers in this podcast are their own and not necessarily those of the editors or of the American Heart Association. For more information, please visit ahagenerals.org.

Komikern och Regissören Pontus Ströbaek (@strobaek) gästar Kult och tar med sig viner från sitt företag EN Halvpall finns på Instagram @enhalvpall och väljer Sidways! Podden är över tre timmar lång och blir filmen till ära en egen Sideways. Den kommer i två delar. Båda finns tillgängliga för Patreons direkt via Acast och det blir man på Patreon.com/branne Viner som vi dricker och kan beställas på Systemet är:  E Ross från producent Poderi Cellario och har Art. Nr. 720 31 Modus Bibendi Nero d'Avola från producent Elios och har Art. Nr. 550 60 Se Nisse Hallbergs "Tomten är Ensam" Biljetter på https://nissehallberg.se/ Kommande filmer i rätt ordning: Pusher   Lyssna på Lord Jens i Falkengberg podcast! Bli Patreon idag på Patreon.com/branne    Länk till min nya standup-special "Baksuz" hittar ni här: https://www.youtube.com/watch?v=uUUtQkPbZK4&t=42s

Komikern och Regissören Pontus Ströbaek (@strobaek) gästar Kult och tar med sig viner från sitt företag EN Halvpall finns på Instagram @enhalvpall och väljer Sidways! Podden är över tre timmar lång och blir filmen till ära en egen Sideways. Den kommer i två delar. Båda finns tillgängliga för Patreons direkt via Acast och det blir man på Patreon.com/branne Viner som vi dricker och kan beställas på Systemet är:  E Ross från producent Poderi Cellario och har Art. Nr. 720 31 Modus Bibendi Nero d'Avola från producent Elios och har Art. Nr. 550 60 Se Nisse Hallbergs "Tomten är Ensam" Biljetter på https://nissehallberg.se/   Se "Lineup" Med Jens Falk, Viktor Engberg och Isak Wahlberg: https://www.nortic.se/dagny/event/42103 Kommande filmer i rätt ordning: Pusher   Lyssna på Lord Jens i Falkengberg podcast! Bli Patreon idag på Patreon.com/branne    Länk till min nya standup-special "Baksuz" hittar ni här: https://www.youtube.com/watch?v=uUUtQkPbZK4&t=42s   Joina eftersnacksgruppen på FB:https://www.facebook.com/groups/121726522077021   Lyssna på mitt nya Standup-album och Mixtape "Forskaren"https://open.spotify.com/album/19Ec9Dica11Va9WkY89qxS?si=sLqi3tRrQBizK0yU3zrQ0Q  

"El futuro del grupo "Los Caracoles" está en manos de los jóvenes".

Tras el derrumbe tienen la misión de rescatar a los supervivientes, y entre ellos a Danny y Ed. Veremos como se movilizan la URSS, la NASA y ELIOS para el rescate. Por otro lado Ellen cada vez más acorralada ve como se desmorona su mandato Presenta: Sergio Valencia Participa: Jimbur Edita: Sergio Valencia Música: OST FAM Space Oddity (David Bowie) Life On Mars (David Bowie) Escucha el episodio completo en la app de iVoox, o descubre todo el catálogo de iVoox Originals

Agradece a este podcast tantas horas de entretenimiento y disfruta de episodios exclusivos como éste. ¡Apóyale en iVoox! Tramas principales: El problema de Rusos y Americanos en compartir los pocos recursos que tienene (se nota que Helios tienen pasta y no reparan en gastos). Los Rusos tienen localizada depositos de agua subterranea, los cuales, han negociado con Elios su extracción. Danny sigue con su paranoia y obsesión que va a más y por último se destapa que uno de los Astronautas es homosexual, Ellen tendrá que posicionarse pero está a punto de saltar un escandalo... https://go.ivoox.com/rf/89922581 Intervienen: Eusebio Arias y Sergio Valencia Edita: Sergio Valencia Música OST For all Mankind - Jeff Ruso My Rifle My Pony and Me - Dean Martin Alright - Supergrass Escucha el episodio completo en la app de iVoox, o descubre todo el catálogo de iVoox Originals

Por Rosmunda Cristiano Não há coisa visível, em todo o mundo, mais digna do que o sol para atuar como símbolo de Deus, pois ilumina com vida visível, primeiro ele mesmo, depois todos os corpos celestes e terrestres. Dante O Sol tem um significado muito importante na Maçonaria. Adorado por quase todos os povos antigos, indica sabedoria, amor e intelecto. Em sentido mais amplo, representa a parte masculina e remete à origem e à razão que traz luz onde a escuridão domina e ilumina o intelecto. Talvez nenhum símbolo seja mais antigo que o do sol e tenha mais significado para o maçom. Chamado Samas pelos babilônios, que é fiador da justiça, Elios pelos gregos, deus do fertilizante, como evidencia o antigo costume da fogueira do solstício de verão, cujas cinzas eram espalhadas para fertilizar os campos antes da nova semeadura. Imagem do bem e governante do nosso destino segundo Platão, era considerada o elo entre o mundo sensível e o mundo supra-sensível, energia que, emanando do Uno, encarnava-se na matéria e possibilitava que todas as coisas voltassem a ser, ao Grande Arquiteto. Juntamente com sua dualidade polar, a Lua é colocada no Leste, e também está presente no Quadro da Loja. O Sol está à direita do Venerável Mestre, enquanto a Lua está à esquerda. Seu movimento marca o trabalho na Loja, pois tanto o Primeiro Vigilante quanto o Segundo Vigilante cumprem seu dever tendo-o como referência. O dever do Segundo Vigilante é, de fato: permanecendo no Sul, observe o Sol em seu Meridiano, chame os Irmãos do Trabalho para o Recreio e do Recreio para o Trabalho. O Sol também é um gerador de luz e calor, portanto de vida. Sem sua existência, todas as formas vivas na Terra desapareceriam. Portanto, não deveria ser surpreendente se, por milênios, na maioria das culturas, ele foi reverenciado como uma divindade vivificante, em oposição ao fraco luar, fraco e pálido demais para desempenhar as mesmas funções que a estrela solar. A chamada "religião solar" é tão antiga quanto o homem. Há vestígios disso desde os primeiros tempos. Inimigo da escuridão e, portanto, da morte, representa não apenas a vida, mas também o renascimento da natureza durante a primavera, quando o frio e a escuridão dão lugar ao calor e à luz e ao próprio homem, quando o gelo e a escuridão da ignorância profana se dissolvem graças à a irrupção da luz iniciática. No momento em que o profano abandona seu mundo anterior e abraça a Luz Maçônica, ele renasce para si mesmo, não apenas simbolicamente, mas realmente, isto é, psíquica e espiritualmente. Ele é, portanto, "homem novo", ou "Homem de Luz" no sentido mais verdadeiro da linguagem simbólica. A Luz iniciática deve ser graduada e proporcional à sua efetiva capacidade de recepção. --- Send in a voice message: https://anchor.fm/malhete-podcast/message

In which the trio is joined by Travis Legge and Rich Thomas to continue their adventure set in the Crossroads Continent, Rich's personal setting for the world's most popular fantasy roleplaying game! * Another Rich Recap! * We battle a tunnel for about 30 minutes * Brynn and Elios get to know each other * Can we swim? * A fight! * Onward * Another fight! * Setting camp Links: Onyx Path YouTube: https://www.youtube.com/user/TheOnyxPath Onyx Path Twitch: https://www.twitch.tv/theonyxpath Onyx Path Discord: https://discord.gg/5uckcBk

Artist: Elios Remixer: Øbsidiaän Label: Feinkost Records Title: Under Ego Format: Digital CAT: FKSTR10 Release Date: 29.04.2022 TRACKLIST: 01. AΤΜOS 02. ZOΦOS 03. YΦESIS 04. YΦESIS ( Øbsidiaän Remix ) Buy the EP here: Bandcamp: https://feinkostrecords.bandcamp.com/album/under-ego-ep Follow FEINKOST RECORDS here: Facebook: https://www.facebook.com/feinkostrecords Instagram: https://www.instagram.com/feinkost.records/ Soundcloud: https://soundcloud.com/feinkostrecords Follow ELIOS here: Instagram: https://www.instagram.com/mike_dellios/ Follow OBSIDIAAN here: Facebook: https://www.facebook.com/obsidiaan.live/ Instagram: https://www.instagram.com/obsidiaan_live/ Soundcloud: https://soundcloud.com/obsidiaan

Az Átlátszó negyedik podcast-epizódja. A beszélgetés vezetője Katus Eszter, az Átlátszó Országszerte rovatának szerkesztője Döbrentey Dániellel, a TASZ Választási Jogi Program koordinátorával, László Róberttel, a Political Capital választási szakértőjével és Zubor Zalánnal, az Átlátszó újságírójával beszélgetett a választási rendszer hibáiról és csalási taktikákról. Az adás felvétele 2022. február 21-én volt. SHOW NOTES Precedens értékű „ítélet”: választási csalást nullázott le a törvénymódosítás: https://atlatszo.hu/kozugy/2022/02/09/precedens-erteku-itelet-valasztasi-csalast-nullazott-le-a-torvenymodositas/ Tiszta szavazás: https://tisztaszavazas.hu Jelentkezz szavazatszámlálónak: https://www.20k.hu/jelentkezz/gs Nyílt szavazás, ételosztás: Forrón és Érpatakon is megismételtethetik a választást: https://atlatszo.hu/kozugy/2014/10/23/nyilt-szavazas-etelosztas-forron-es-erpatakon-is-megismeteltethetik-a-szavazast/ Ma már kamionsofőrként dolgozik az Elios-ügyet elsőként leleplező tényfeltáró újságíró: https://atlatszo.hu/kozpenz/2022/02/14/ma-mar-kamionsoforkent-dolgozik-az-elios-ugyet-elsokent-leleplezo-tenyfeltaro-ujsagiro/ Az Átlátszó választási oldala: https://atlo.team/valasztas2022/ Katus Eszter Facebook oldala: https://www.facebook.com/keatlatszo
Szabó Krisztián Facebook oldala: www.facebook.com/szabokrisztianadat A TASZ weboldala: https://tasz.hu/rolunk TASZ Választasz tematikus oldal: https://valasztasz.tasz.hu A Political Capital weboldala: https://www.politicalcapital.hu
Az Átlátszó Facebook oldala: www.facebook.com/atlatszo.hu/
Az Átlátszó Instagram oldala: www.instagram.com/atlatszo/?hl=hu
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Az Átlátszó YouTube oldala: www.youtube.com/c/Atlatszovideo
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Iratkozz fel a heti hírlevelünkre: mailchi.mp/atlatszo/mutyimondo_1124_1-396651

Benvenuti o bentornati su mangianastri amici e amiche!Oggi parliamo di Mitologia... ma anche di Paole, di Dei che fanno a pizze, di tarantole (che schifo), di lupacchiotti bianchi a cui fare i grattini, di tube, di vagine assassine, di kami, di Patroclo che ciula con Achille, di Percy Jackson, di quanto non aspettiamo Uncharted, di sonno, di stanchezza e, soprattutto, di Videogiochi Film e Libri.Buon ascolto :)ŌkamiIn un non specificato periodo del Medioevo Giapponese il lupo bianco Shiranui e lo spadacino Nagi si trovano a dover combattere il demone a 8 teste Orochi. Nonostante riescano a vincere sigillando Orochi, Nagi rimane ferito e muore per colpa del veleno. 100 anni dopo qualcuno toglie il sigillo a Orochi e la dea del sole Amaterasu torna per salvare il Giappone.CirceCirce è una ninfa, figlia del titano Elios e della nereide Perseide. Dopo millenni passati nel palazzo del padre a vivere solo sullo sfondo, trasforma con delle erbe un uomo in divinità e una bellissima ninfa in un mostro; confessa le sue colpe al padre e viene esiliata sull’isola di Eea. Inizia quindi per Circe un periodo di solitudine, di vera scoperta personale e di incontri straordinari.American GodsDopo essere uscito di prigione, Shadow Moon accetta un lavoro come guardia del corpo dell'enigmatico Mr. Wednesday, che cela l'identità di Odino. Il dio norrenk sta radunando tutti le divinità delle antiche religioni in giro per l'America per combattere una guerra contro i nuovi dei che hanno preso il loro posto nella fede degli uomini. Ma che ruolo ha Shadow in tutto questo?Articolo super figo su Okami I nostri consigli:God of WarThe Banner SagaHadesIliade - Odissea - EneideLa canzone di AchilleSatyricon MetamorfosiPoema a fumettiBlood of Zeus Gli ArgonautiThe Green Knight This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit mangianastripodcast.substack.com

Derrin builds empowered individuals and teams, systems for growth, motivated communities, and strong companies. Having founded/co-founded 10 companies to date. The most recent company is RevRoad, a venture services firm, with a portfolio of 44 high growth technology companies. He has worked across the United States and over a dozen countries around the world. Derrin's greatest priority is his role in building a great marriage and a wonderful family with his wife Nicole and their five children. He is a graduate of Duke University Fuqua School of Business and Brigham Young University in Provo, Utah.While growing many companies organically, Derrin has also created growth with several M&A events. These deals ranged from several million dollars to well over $100M. Derrin has also led many government relations campaigns working with Governors and state legislatures to establish legislation and funding for state level business deals in over a dozen states. Derrin has served as a Director on many Boards including the Smithsonian Science Education Center, the DECA National Advisory Board, BYU Rollins Center for Entrepreneurship & Technology, and the Virginia Tech Innovate National Advisory Board. corporate boards such as Imagine Learning, Glynlyon, Journeyfront, Elios, PhoneSoap, Hallo, RaceReady, and others.At Imagine Learning Derrin led all revenue activities from the start and today Imagine Learning serves over 2 million students each day. As majority owner and chairman of the board at PhoneSoap, he helped the team grow from an early prototype and almost no revenue to being the industry leader in UV disinfection to prevent infectious disease. These patterns of growth continue at RevRoad and RevRoad portfolio companies. In addition to entrepreneurial ventures and building companies as a board member, Derrin helped create the digital division at the world's largest educational publisher, Pearson Education with record-breaking success.Volunteer service is important to Derrin with service to the Boy Scouts of America, DECA, Junior Achievement, Rising Star Outreach India for those affected by leprosy, Mother's Without Borders, Dahlia's Hope, The Responsibility Foundation, Ryan White Program, The Family Support & Treatment shelter for battered women and children, a variety of youth groups, public school community councils, church and civic organizations.Derrin grew up on a farm in Missouri where he learned the importance of growth, to work smart and hard, the power of teams, and to be amazed by people and nature.  He graduated High School in the top of the class while working two part time jobs to save money to serve as a volunteer for two years in Australia at 19 years old.Derrin's Specialties: Leadership, strategy, mergers & acquisitions, government relations, building sales organizations and systems, competitive analysis, contract negotiation, effective compensation structures, branding, attracting and retaining the strongest industry talent, forecasting, building sustainable and profitable business models.

We discuss the webtoon My Deepest Secret: the original portrayal of Elios, Emma's mental illness, Yohan's choice, the plot twists, and the ending. Let us know what you think below!

The WPOV Crew Discuss: Cody heel turn? Sting & Darby, Elios top 10 tag team, Hot Tag News: Bron Breakker battle for the “A” show, Raw(11) vs NXT(5) vs Dynamite (6) vs SmackDown(7), Rampage (1), Who Made the Book?, The 5 Second Shuffle & MORE!!!!

Il Prof. Daniele Coluzzi ogni venerdì, a partire dalle 16:15, interviene con Valerio Cesari, Riccardo Castrichini ed Emanuele Forte, durante “Antipop”, per parlare di mitologia. Podcast del 03 dicembre 2021.

Welcome to Drone World, the drone podcast by Coptrz! In this episode, your host George Burne gets behind the propellors with Flyability's Junio Palomba. Swiss-based innovators Flyability launched the game-changing ELIOS 2 inspection drone over 2-years ago and are still finding remarkable applications. From inspecting coal mines and culverts to dangerous cement kilns and offshore drilling ships, Flyability are still pushing the boundaries. The driving force behind this innovation is protecting human life, if you could put a robot into these dangerous environments instead then why wouldn't you? Whether at height or in confined space Junio added “There is a positive correlation of the penalties companies face for fatalities and the adoption of this technology!” Hear about the latest innovations to the ELIOS 2 including the RAD edition for the nuclear industry and the power of Inspector 3.0, the latest inspection software. See it in action here using Inspector 3.0: https://www.youtube.com/watch?v=YNm3jwFOmJY Head to our website to find out all about the ELIOS 2: https://coptrz.com/elios-2-confined-space-inspection-drone/ Don't forget to rate and subscribe to Drone World, the podcast by Coptrz.

Hallgassa meg a legfrissebb híreket, tényleg csak pár perc! A közélet, gazdaság aktuális híreiről, a társadalmat érintő változásokról röviden szól a friss hírek podcastunk. A felolvasott hírek itt érhetőek el: https://podcast.hirstart.hu/friss-hirek/2021/09/01/5133/

Hallgassa meg a legfrissebb híreket, tényleg csak pár perc! A közélet, gazdaság aktuális híreiről, a társadalmat érintő változásokról röviden szól a friss hírek podcastunk. A felolvasott hírek itt érhetőek el: https://podcast.hirstart.hu/friss-hirek/2021/09/01/5133/

Smokin Rudy - California Crusin "Hay Hay Elios"

For the first time ever, we brought the whole team together to recap DM Tony's very highly customized version of Storm King's Thunder. Hear what all 5 players and Tony thought of the game and what they have to say about the CRAZY MAGIC ITEMS in it, his changes to the campaign, fitting in their backstories, and more! Along the way, we talk about fighting the Kraken, befriending (most) of the giants, and how we all became The Avengers in a Halloween game. If you're wondering just how far a DM can push a book module beyond what's written before your players balk, this is the episode for you. You'll hear how Tony pulled off his tricks, how the players reacted to them, and the secret backstories and DM canon we never got to see. 1:00 Introducing the players 3:00 A high-magic party for a high-magic campaign 4:00 Jacob: The middle-aged police detective turned dad-rage barbarian with his dead wife playing ancestral spirit. 7:00 RO4M: The “repurposed” Warforged warlock with a random personality track 9:00 Wilhelmina Draughall: The Sorcerer-Warlock dedicated to convincing the Raven Queen to save her brother's life. And her pet alcoholic imp, Morningstar 10:00 Roderick R.R. Draughall: The dying nobleman based on Vincent Price from The Fall of the House of Usher 14:00 The Draughall's secret backstory and how the big campaign plots battled with personal storylines for airtime 21:00 Playing Zhang Fei: A lawful neutral samurai bugbear raised up from a slaughtered goblin warren by his cruel Daimyo 25:00 Enter Erasmus the half-giant DMPC replacement wizard 34:00 How Tony worked PC backstories into the wider SKT plot, one plot twist a player vetoed, and one we never got to 37:00 The 3 Guardians of DM Tony's SKT: Zephyros, Elios and Traxton the Troll King (Hint: two of those aren't in the book) 41:00 DMing a party that talks its way out of half the encounters 45:00 What you gain and lose when the players don't share their backstories with the party – and the stolen Wish! 49:00 Jacob's secret backstory (and Erasmus's) 53:00 How much of Tony's story and headcanon did the players actually catch? 58:00 Bryn Shandar: Where the party started making friends and influencing giants 64:00 Our favorite moments from the campaign Going ham on the Hill Giants Racing the Frost Giant demigod Tagrim's dragon-drawn Spelljammer longship for The Ring of Eternal Winters Recovering Jacob's memories (which included the murder of the Queen) Wielding the fulling empowered Hammer of Thunderbolts 71:00 The Weapons of Legend! 81:00 Other items, boons and buffs DM Tony showered upon the party 86:00 Why DM Tony doesn't think jacked attribute numbers matter 87:00 Running the Kraken fight against 11th level characters 90:00 Final thoughts and the Avenger we each became in the Halloween game Support this podcast

When is a book module not a book module? When the DM throws in birthday games, a modifiable Spelljammer airship, legendary weapons tied to every character's backstory, and more deviations from the standard campaign than we could count. That's how DM Tony made Storm King's Thunder his own. We just wrapped this epic campaign at level 11 after 16 sessions. Now the 3 Wise DMs are comparing notes on the episodic, exploration-lite, story-focused approach Tony took with it, how that felt to play in, and what you can learn about making Wizards of the Coast published campaigns fit your table and DMing style. Click the episode to hear all this and more, as we break down the 9 main deviations Tony brought to Storm King's Thunder and the DM's perspective on running it. Then come back for our next episode, when we bring in Tony's players and hear what they thought of his approach to DMing the game and their characters. 2:00 Wrapping up our first 3 Wise DMs campaign: DM Tony's Storm King's Thunder 4:00 How we did it: 11 levels in 16 game sessions, and how that compares to our other campaigns 7:00 The two Erasmuses 10:00 From book to tabletop: Getting Storm King's Thunder ready to play 12:00 The 1st Deviation: Why the party meet-up matters, and how Tony got the party working together 17:00 High magic and The 2nd Deviation: Zephyros's Guide to Turning Your Party Into Tactical Brilliance 20:00 The 3rd Deviation: Putting in boons and items that boost PC's lower stats is “harmless” 22:00 Dealing with intraparty jealously and making sure the PCs are on par with each other 28:00 What did Tony keep from the original campaign? 70%! Really! Only about 30% Changed! 30:00 Get on the Highwind! Why we did SKT as a whirlwind tour instead of meandering exploration 33:00 The 4th Deviation: Zeus's Lightning Bolt and Mjolnir? Every character gets a legendary artifact weapon! … You just have to take it off a giant chief 35:00 An EPCOT World Showcase Forgotten Realms experience 41:00 The 5th Deviation: Opting out of the build-it-yourself side quests to off-book places like Waterdeep (and getting up to 35%, 40% changed! Honest! Only 40%!) 45:00 Worthy side quest motivations? “Go save the world! But first, go to that city 500 miles away to tell this courier's widow that he's dead.” 49:00 Tony's formula for creating legendary, character-specific magic items. 56:00 The Curse of the Draughalls 58:00 A chapter-by-chapter rundown of our run through Storm King's Thunder 59:00 The 6th Deviation: Nightstone and the early quests we skipped to do Dave's birthday right 67:00 The 7th Deviation: King Traxton's Mountain and DM Tony's take on the airship (which was promoted from blimp to a Spelljammer ship that let the party race a Storm Giant Demigod for the Ring of Winters) 69:00 The 8th Deviation: Skipping the exploration and jetting off on DM Tony's Celebration of Gaming 73:00 The All-Father's Path, fighting every kind of giant in one encounter, and The 9th Deviation: visiting Elios's Sky Mall (50% It was only 50% different! Honest!) 78:00 Prep for DMing like you're giving a presentation 82:00 Final thoughts Support this podcast

In this audiojournal entry, I share some updates on what I've been doing this weekend, as well as some ideas that's been floating in my head recently. Tldr; I made some good progress on my EliOS through setting my priorities. I also made progress on my design apprenticeship creating a complex, accessible database with unique QoL features. I've also been thinking about what a card based RPG game could be like. Furthermore, I've created a metaphor to help gain a better perspective on the value of human history. If human history was a bank account, modern western society nets is just $3-400, agricultural and neolithic society nets us just $2k-4000, and hunter gatherer cultures nets us a whopping $50k-200,000!! There is a lot of wealth in wisdom to be had from ancient cultures.

'IT'S ERIK NAGEL'  Cold Start SEGMENT 01 [5:52] Nor'Easter. Xia's 1st snow storm. Trevor's snow day in the city Erik's new doctor. Steam heat. French bread vs Elios pizza. School lunches. New Marvel projects. SEGMENT 02 [1:18:54] Movie updates. Marvel updates. Tom Cruise on-set rant. TV/Streaming updates. FOLLOW 'IT'S ERIK NAGEL': TWITTER | INSTAGRAM | FACEBOOK | WEBSITE HEAR 'IT'S ERIK NAGEL' ON: IHEARTRADIO | SPOTIFY | APPLE PODCASTS | GOOGLE PODCAST | YOUTUBE

The Frothcast is back! 2 Years later and I'm frothinnn'. Dig in to this audio buddler as I emerge from hermitude and discuss being in Hawaii, this year's Vans Triple Crown of Surfing, some of my favorite tunes, books, and my top 5 favorite pizzas in LA. In addition, I have a chat with a metal dude and answer all your questions from 2 years ago. Please rate, review, and keep it frothy! Cheers -Hendo EPISODE SPONSOR - The Ampal Creative- https://www.theampalcreative.com/ 20% OFF PROMO CODE: FROTHCAST20 @Ampal_Creative Recorded at @HawaiiWorkShop VANS TRIPLE CROWN - https://www.vanstriplecrownofsurfing.com/ Makua Rothman Shark Tours: https://www.haleiwasharktours.com/about-us/ MUSIC - Favorite Albums of Albums: https://open.spotify.com/playlist/5ykM9kSXDQFiuiIp0UzlrL?si=YZC_LVM5QfCdpLEFGu3kXA BOOKS - Favorite Books of Quarantine: 1. Big Magic by Elizabeth Gilbert 2. ‘The Five People You Meet in Heaven' by Mitch Albom 3. ‘Pipe Dreams' by Kelly Slater Honorable Mention: ‘Zen and the Art of Motorcycle Maintenance' by Robert M Pirsig HEALTH/FOOD - Top 5 Favorite Pizzas: 1. @HailMaryPizza 2. @DeSanoPizzaLA 3. @Elios.Wood.Fire.Pizza 4. @SouthEndVenice 5. @StellaBarra Mental Minutes With Metal Meehan: @StratusGoodsCo World Surf League Events: https://www.worldsurfleague.com/ Questions: @TheGreenRoomTimes, @AldenMilby, @LemooreSurfingClub/@Surfival_League, @BoomShakaLaka,, @JamesBillingPhotography Lime - Angel Eyes (Hendo Re-Froth) https://soundcloud.com/hendo_froth/angel-eyes EPISODE SPONSOR - The Ampal Creative- https://www.theampalcreative.com/ 20% OFF PROMO CODE: FROTHCAST20 COVID-19 Resources: https://www.cdc.gov/coronavirus/2019-ncov/index.html Thanks for listening m/ @TheFrothCast @Hendo_Froth --- Send in a voice message: https://anchor.fm/thefrothcast/message Support this podcast: https://anchor.fm/thefrothcast/support

Generally speaking, we mainly have failures of follow up in B2B sales.  The conduct of the sale's meeting is normally done professionally.  Perhaps the salesperson could have asked better questions or presented the application of the benefits of the solution better. Maybe they could have dealt more professionally with objections or closed the deal more effectively.  In B2C though, the troubles start from the point of contact.  Getting this wrong means no meeting, let alone no sale.   I blame the managers for these issues.  If they were doing their job properly, then there wouldn't be these customer facing problems.  We are salespeople and we are also buyers.  We go shopping, we eat out, we buy lots of stuff in the face to face environment.  Maybe not as much as before, because of Covid-19, but we still we do engage in some B2C activities.  When the whole hospitality industry is on its knees, you expect that those survivors still operating, are really maximising their opportunities to build their clientele.   Imagine my surprise when I called a restaurant in Midtown for a lunchtime booking and bumped into some idiocy that flies in the face of the current reality.  It was around 11.31am and I was calling to make a booking for a 12.00 luncheon.  The staff member who answered the phone told me that all bookings for lunch close at 11.30am.  I could just show up at 12.00 and take my chances with the rest of the punters. It is 11.31am when we are having this conversation.  I asked him does that mean I should book at another restaurant instead of his.  There are tons of restaurants in Midtown by the way. Irony and sarcasm aren't really features of the Japanese language, so my obtuse point went straight over his head.   He had been told that bookings for lunch close at 11.30am and that was that.  The idea that we are in the middle of a pandemic and that many enterprises in his industry are closing for lack of business, would warrant additional flexibility wasn't one that had ever crossed his mind.  He couldn't connect the dots and realise that what his job depends on are customers.  It was not clear to him that every restaurant wants to build new clients and to boost the spending of their regular clients.  He is just an employee, so building the business isn't part of his work remit.   Well it should be.  He could have been focused on grabbing my booking, guaranteeing two covers at lunch, rather than relying on providence to supply walk-ins off the street.  He could have made me feel special by telling me that although 11.30am is the cut off point, he would take the booking anyway and really looked forward to meeting me at 12.00, “Ask for Taro and I will take care of you”, he could have said.  How would I have felt?  Would I have become more likely to go back again in the future?  Could I become a valued customer?  The answers are obvious to me but the concept was not in his mind.   By way of contrast, I like Elios in Hanzomon, which is across town for me.  I have been going there with clients and with my family, since 2001 when I came back to Tokyo from Osaka.  What is my lifetime value as a customer?  Elio certainly knows this equation and so do his staff.  That is one of the reasons why I keep coming back.   So I was wondering what is the difference and the reasons are obvious.  The leadership outlook and work culture of the restaurants are different.  The bosses determine the way the staff think about the business and the customers.  So, the natural extension of this reflection is to move to self reflection.  Are my staff flexible when dealing with our clients?  Are they just following the rule book and not using their brains?  Do they feel trusted enough to take responsibility to fix an issue for a client or are they ninjas, hiding behind the rules.  As the boss, you cannot be in every client conversation, so you have to delegate client care to your team.  Let's all take another look at the culture we have created.  Are we allowing individual decision making based around a common understanding of how we think about our clients?   One of the things we quickly learn as leaders is that telling people something once, almost guarantees no one will remember it.  It becomes annoying to have to keep repeating the same things over and over, but you find you have to do it.  So, it always a good practice to remind everyone about how we think about serving the client.  Explain where this aligns with the value system, the vision and the mission of the enterprise.  There has to be a symbiotic relationship between our teams and the clients. The boss determines how that plays out at every micro-interaction, every day.

https://soundcloud.com/m-ellios

Munkatársunk a pécsi Elios-ügyről beszélt a Klubrádió műsorában.

Some truth is coming to light! Sophie, what have you done?! Elios shows up on the class trip. Yohan draws some interesting conclusions. Josh & I are discussing episodes 59-63 of My Deepest Secret by Hanza. Support My Deepest Secret Creator Hanza: https://www.patreon.com/hanzastudio Connect with Girl Wonder:  My Patreon: https://www.patreon.com/girlwonder My YouTube Channel: https://www.youtube.com/channel/UCTk-JbxxAnf5TKyeCchNRHA twitter.com/girlwonderpod instagram.com/girlwonderpodcast Email: girlwondersquad (at) gmail (dot) com Buy me a coffee: http://ko-fi.com/girlwonderpodcast

En este episodio presentamos a algunos de los grandes de la guitarra, herederos de Django. Elios y Bulu Ferré, Christian Escoudé en Francia. Siguiendo por Stochelo Rosenberg y el trío homónimo de Holanda; así como de Philippe Catherine de Bélgica a quien Mingus llamó Young Django. El prodigio Bireli Lagrène de Alsacia, Mandino Reinhardt y de Lorena Dorado y Tchavolo Schmidt. Les Doigts de l'Homme y final con el Hot Club de San Francisco.

This week on Episode 465 of Priority One --- We ‘Trek Out' Culber's focus on mental health, Goldsman's tease of Picard season 2, Jack Quaid's initiation into Trek-stardom, Gossipy-Gossip, and a teeny-tiny set! Of course, as always, before we wrap up the show, we'll open hailing frequencies for your incoming messages Let us know on social media like Facebook, Twitter, or by visiting our website! This Weeks Community Questions Are: CQ:  Are you excited to see more “Starfleet” in season 2 of “Picard”, or would you prefer the second season to focus on something else entirely? TREK IT OUT by Jake Morgan Wilson Cruz on Culber's Mental Health What would it feel like to be resurrected - Pulled from the clutches of death, returned into the land of the living? The wholly unusual event must be disconcerting - being one of the few people pulled from eternal oblivion. Just ask Spock, McCoy, Scotty, Worf, Wesley Crusher, Janeway, Picard - or Dr.Hugh Culber. Wilson Cruz, the actor who portrays the resurrected Doctor - Culber not McCoy - discussed the effects of breathing again with Yahoo Entertainment's “The Talk”. Cruz told “The Talk” that he didn't originally know his character was going to be killed, but was glad to receive a call shortly after to reprise the role. During those conversations, Cruz made it clear that he didn't want Culber's death to be meaningless “So many times we see these LGBQ characters, especially gay characters, killed off on our series, and there's no cost. It's as if it never happened. And I wanted there to be growth in this. He needed to learn something from it, we all did. So, I was excited about the epic way he was brought back” Cruz continued, dropping a few hints about what to expect in Discovery's third season ”I'm more excited about how he's grown in season 3 - how he's used this experience to kind of inform the way that he works on the ship. And so, we'll see more of how he works as a doctor, but also how he's taking into consideration mental health.” Akiva Goldsman Talks Picard's Second Season Wilson Cruz wasn't the only Trek-insider to talk about the future of a Star Trek series. Writer, Director, Show runner, and now prolific video interviewee Akiva Goldsman discussed Star Trek: Picard's first season, and what we may expect going forward. Goldsman told IndieWire's Christian Blauvelt that the introduction of Altan Inigo Soong, played by the incomparable Brent Spiner, served a bigger purpose than simply moving the narrative. ”We knew that this Soong character had been in our head canon when it came to the season, anyway. But, you know, we want more Brent, and we wanted to create a platform for which there could be more Brent in ensuing seasons” In regards to the introduction of the Riker-led Starfleet Armada in "Et in Arcadia Ego — part II," Goldsman acknowledged ”We knew that bringing in that fleet was a little bit of a promise, and so we tried to be thoughtful about it”. The video interview ends there, but in the article that accompanies the video, Goldsman is quoted as saying ”Especially as we go forward, we're going to start making statements about really what the world of Starfleet, at least technologically if not socially and culturally … These are the things that are likely to get a little bit more play than they did [in Season 1] in what was essentially a story about somebody who is outside of Starfleet.” For more on the development of Picard's first season, including the inspiration for the 2390's ship design, be sure to trek out the link in our show notes. Jack Quaid Describes “Lower Decks” If you're involved in Trek, no matter what else you are working on or promoting, you WILL talk about your Trek involvement - and Jack Quaid had his first lesson in this. The star of the upcoming animated comedy “Lower Decks” sat down with Entertainment publication Gold Derby to promote season 2 of the popular Amazon Prime series, “The Boys” - and as sure as the sun rises, Star Trek was addressed. Quaid, who plays “Lower Decks” Ensign Brad Boimler, admitted he wasn't sure about a release date, telling Gold Derby ”I don't know when it's coming out. I know I've recorded most of my stuff for it but it's a new “Star Trek” show, it's animated, it's from Mike McMahan, who's one of the writers on “Rick and Morty” and he's frickin' hilarious.” Like the aforementioned McMahon, Quiad stressed the comedy is for both trek fans - like self-proclaimed “trek nerd”, Gold Derby reporter Kevin Jacobsen - and non-trek fans ”If you are a huge “Star Trek” nerd[...]you're gonna get a lot of the references and a lot of the deep cut jokes, but I think even if you're new to it, I think it's something really cool to introduce you to the “Star Trek” universe as well. Me speaking personally, I didn't know a ton about it when I got cast. I had seen the J.J. Abrams movies but now I'm into it.” Kirk-shipping May Be Canon? You want gossip, Captains? You've got it. We head back to the questionable “WeGotThisCovered” for our next story, so be sure not to take this Gossip as Gospel. If you'll remember back in episode 460 of Priority One, we told you about the RUMORED casting of a young James T. Kirk for the upcoming Pike/Spock/Number 1 series, “Strange New Worlds”.  This week, WeGotThisCovered has doubled down on the rumor, claiming that not only are they casting Kirk for the series, but he may be Bisexual. According to the site ”Trusted insider Daniel Richtman has revealed on Twitter that sources are telling him Kirk could end up being portrayed as bisexual in SNW.” https://twitter.com/DanielRPK/status/1271905503678009344 You may be surprised to find out that the Original Kirk - William Shatner - had an opinion on the matter. On June 14th, Shatner TWEETED ”I suppose some of you want my reaction to the article from the “never heard of them before & clickbait rules” site on their scoop on bisexual Kirk? If @CBS,@Alex_Kurtzman & @Startrek decide  to make Kirk bisexual to align with cancel culture presentism; then it's OK

Why No Omotenashi From Some Chinese Retail Services In Tokyo?   This is a controversial piece today, because I am singling out one race, one group in isolation.  It is also a total generalisation and there will be exceptions where what I am saying is absolute rubbish.  There will be other races and groups, who are equally guilty as well, who I am not singling out or covering, so I am demonstrating a blatant and singular bias. I know all that, but let the hellfire rain down on my head, I am just sick of some of this lousy service here in Tokyo.    It is a mystery to me how the service in some Chinese restaurants here can be so oblivious to Japanese standards of omotenashi.  Omotenashi is that sublime combination of anticipating and exceeding client's expectations, that has made Japanese service so famous.  I love Chinese cuisine and I enjoy the high quality standard of Chinese food in Japan.  They have the best, most expensive quality, very safe ingredients and really great Chinese chefs here. When I go to places in Tokyo like Akasaka Shisen Hanten in Hirakawacho or Heichinro in Chinatown in Yokohama, the service is very, very good.  My observation is that is probably the case because the serving staff are Japanese or Chinese who have grown up here.    Whenever I go to some “all Chinese” affairs, with only Chinese staff, I find the service is disappointing.  I had this experience again recently in the Azabu Juban.  It was a first and last time to go to this particular restaurant. The food taste wasn't the issue, in fact some dishes were delicious.  It was the total disinterest on the part of the serving staff and their manager.  You don't feel any particular need to go back there, when there are a hundred other restaurants within a five minute walk.    This makes no sense to me, because when I am Singapore, Hong Kong or Taiwan, the restaurant service is usually very good.  Obviously, the more expensive the restaurant, the better the service of course. So there is nothing inherently missing in the service mentality and capability, that couldn't be applied in Japan.  Why then is it so lacking in omotenashi?   I remember reading a purported Chinese saying that, “A man who cannot smile, should not open a shop”.  Obviously, some of the Chinese staff working in these establishments I am complaining about, have never heard of that piece of ancient Chinese wisdom.  Smiling, making you feel welcome, treating you well are a big fat zero in my experience.  The way of serving is very perfunctory, even rough, in some cases. Japanese style restaurant table service is generally very much more refined.  What is driving this difference and what does it mean for the rest of us in the service business?   Perhaps some of the Chinese staff we are seeing serving in Japan are students. According to the media reports, many are actually working almost full time.  They are not professionally trained service staff, in the sense that this is their career.  Coming from certain parts of China and from different socio-economic backgrounds, they may have had no exposure to what good levels of service looks like.  I went to China for the first time in January 1976 and have been back a number of times over the years.  I studied Chinese language, history and politics at Griffith University's Modern Asian studies faculty. I like many aspects of Chinese culture and studied Tai Qi Quan for about ten years with my excellent teacher, Cordia Chu in Brisbane, before I moved back to Japan.  I haven't been back to China for a while, but I don't recall the service being particularly bad when I was there last.  Perhaps some of these local serving staff living here in Japan only ever eat Chinese food, so they are never exposed to how Japanese restaurants serve their clients. I find that hard to believe though.   The thing that puzzles me most is that despite the fact these Chinese staff are working in Japan and are floating in a deep ocean of omotenashi, some don't seem to picking up any ideas on how to treat their clients.  Why would that be?  The managers are also Chinese, so they are responsible for leading their staff in the restaurants.  Are they oblivious to the service market in Japan and how it functions?  Are they just poor managers, who cannot place their operation in a broader context of local service standards.  Are they inflexible and incapable of understanding the lifetime value of a repeater client?    This is a very competitive restaurant scene here, has more Michelin starred restaurants than Paris, so you would expect that everyone, including some of these Chinese run establishments, would be doing everything they can to build a loyal, repeater client base.   This challenges me to consider what we are doing in our own case, with our customer facing service.  If I am going to bag some of the Chinese restaurant's service here in Tokyo, then I had better consider our own standards at the same time.   We are a gaishikei or foreign run establishment here.  I am not Japanese, but I am the boss.  Am I operating the company service provision in terms of what I am used to in Australia, my home country?  Am I doing an Australian version of what some of these Chinese restaurants are doing here in Tokyo in their service business?  Are we in fact, providing enough omotenashi service to our own clients? Could we do better in this regard?   I find a lot of Japanese service very polite, but also rather impersonal and almost robotic sometimes.  Compared to the poorer versions of some of these Chinese restaurant service offerings however, I will take the Japanese polite, impersonal, robotic option every time. How can we see our service businesses in a different light?  How can we make sure we are not only providing omotenashi levels of service, but are going beyond that, to offer a more personalised experience? Maybe we need to audit what we are doing, to see if we are missing some vital areas for improvement.   I really like Elios Locanda Italian restaurant in Hanzomon, because I am treated like one of the family.  This is the feeling transmitted through their Japanese staff. Elio himself, is not always there, all the time, but that authentic Italian family style service is there.  He is setting the service standard and the Japanese staff are following it.  I see this example and I think to myself, “it is possible to have a more personal level of service here, transmitted through your Japanese staff”.  My family and I have been regulars at Elios since we returned to Tokyo from Osaka in 2001. Talk about the repeater, life time value of the customer.  They have seen my son grow from a baby, to a young man in that time.  We are part of the family and this is the key - we were made to feel like that from Day One.   How about your service provision standards?  Are you making your clients feel like part of the family?  What is your repeater rate?  How many people continue to buy from you, year after year? Are you tracking this?  Do you know what the average buying continuity rate is with your customers? When we see bad service, it is always a good reminder to make sure that what we are doing ourselves is at the required omotenashi level.    If you are not sure what I am talking about with this omotenashi thing, here is my recommendation. Go to a very upscale Japanese kaiseki restaurant preferably in Kyoto or a Toraiya traditional sweets coffee shop and remind yourself what excellent service looks like. Then reflect on what you are offering in service terms. Break down your every touch point with your customers and clients and see if there isn't a lot more omotenashi that can be introduced in each case.  We can always learn from our own mistakes and from the mistakes of others when it comes to providing better service.  The point is to observe carefully, change quickly and commit to massive improvement.

Indoor drone inspections have become an enormous ROI booster for energy companies who own and operate industrial assets. Patrick Thevoz is CEO of Flyability, a Swiss company who specializes in building indoor inspection drones. Their latest drone, Elios 2, is an impressive feat of engineering. Patrick joins Ian to discuss the value that indoor inspection drones are bringing to their large enterprise customers. He also explains the engineering designs and decisions that went into the making of Elios 2.

Munkatársunk a váci Elios-ügyről, és a közadatigénylésekről beszélgetett a műsorvezetővel a Klubrádióban.

Guilherme Goinhas is one of the very few operators that I've spoken with that is conducting indoor industrial inspections with the Flyability Elios drone system. I remember seeing the Elios on a few videos online, however it's great to hear from someone that is actually using this unique drone for a commercial purpose. Show notes: https://thedronetrainer.com/podcast-013-guilherme-goinhas-portugal/

In this third episode of the show, I talk with Jeremiah Karpowicz of Diversified Communications. Diversified Communications is the producer of the the Commercial UAV Expo Americas and Europe events.  These events are focused specifically on various commercial and industrial uses of drones. Commericial UAV News is their hub for content and the place to go to explore the hundreds of artlices, interviews and other content they have produced.  Jeremiah has produced over 250 pieces of content of his own. Topics we touch on in this episode include: There’s a big difference between saying, “we need to look at drones,” versus, “we have this problem, and I think a drone can help solve it.” Inventory Management and Chemical Detection Mining, Construction, Utilities Applications Importance of showing ROI Data, Data, Data! Purchase of Drone World Expo Benefits of attending in person events Making the technology work for you right now You can connect UAV Expo and Jeremiah in your favorite social media spaces. Also mentioned in the show Jeremiah's Interview with me in 2016 Commercial UAV Expo Colorado Center of Excellence for Advanced Technology Aerial Firefighting (CoE)  Flyability Airware Bechtel Unmanned Aerial Services DJI Enterprise Kespry Apellix Painting Drone Connect with me Send me an email with your thoughts and with guest suggestions mark@industrialdrones.org Subscribe to the Industrial Drones Podcast on Apple Podcasts or on Android Join the Facebook Group to join the conversation  Follow @industrialuas on Twitter See it all at industrialdrones.org If you like the show and want to show your support, you can do so through my Patreon page. Exploring unmanned solutions to real world Industrial problems.

In this first episode of the show, I'm privileged to talk with Johan Mlouka of Flyability, SA.   Flyability is the maker of the Elios drone -- a head-on approach to dealing with obstacles.  Elios is designed to go where other drones can't and where people shouldn't go.   In the interview we focus on the industrial use cases for the drone, but Flyability's overall focus is much broader and actually started with a focus on search and rescue. There is great potential for this inspection tool in industrial settings for confined space entry and access to otherwise inaccessible spaces. Check out their website where you can see some case studies and start thinking about where you can use this at your site. You can connect with Flyability and Johan in your favorite social media spaces.   Also mentioned in the show Commercial UAV Expo   Connect with me Send me an email with your thoughts and with guest suggestions mark@industrialdrones.org Subscribe to the Industrial Drones Podcast on Apple Podcasts or on Android Join the Facebook Group to join the conversation  Follow @industrialuas on Twitter See it all at industrialdrones.org If you like the show and want to show your support, you can do so through my Patreon page. Exploring unmanned solutions to real world Industrial problems.

Dan Cohen from GearDiary.com was in Detroit with GD Meg, but happens to live in the neighboorhood, so he came to the studio to talk green car tech. Also, did you know you can recycle old christmas lights? and a great GD Foodie-Phile report on why we should love oats.