Podcasts about goethe university frankfurt

In this episode, we explore the contributions of this year's Nobel Prize laureates in Economics – Daron Acemoglu, Simon Johnson, and James Robinson – and their work on the role of institutions in shaping economic prosperity. Our guest, Navid Sabet guides us through their core findings and shares his perspective on their influential research and its impact on the field of political economy. Finally, he connects these insights to his own research, examining how institutions affect immigration reform and economic opportunities.   Navid Sabet is Assistant Professor in Economics at Goethe University Frankfurt. His research interests lie in the areas of political economy, applied microeconomics and public economics. Navid mentions the Nobel Prize winners' famous paper from 2001, “The Colonial Origins of Comparative Development: An Empirical Investigation”. You can find it here. For more info on Navid's research, you can check out his homepage or his paper on Immigrant legalization and the redistribution of state funds in the US.  

Lauren Kaplan is a sociologist and writer. She earned her PhD in Sociology at Goethe University Frankfurt and worked as a researcher at the University of Oxford and UC Berkeley. The Impact of UX Research in the AI Space // MLOps Podcast #272 with Lauren Kaplan, Sr UX Researcher. // Abstract In this MLOps Community podcast episode, Demetrios and UX researcher Lauren Kaplan explore how UX research can transform AI and ML projects by aligning insights with business goals and enhancing user and developer experiences. Kaplan emphasizes the importance of stakeholder alignment, proactive communication, and interdisciplinary collaboration, especially in adapting company culture post-pandemic. They discuss UX's growing relevance in AI, challenges like bias, and the use of AI in research, underscoring the strategic value of UX in driving innovation and user satisfaction in tech. // Bio Lauren is a sociologist and writer. She earned her PhD in Sociology at Goethe University Frankfurt and worked as a researcher at the University of Oxford and UC Berkeley. Passionate about homelessness and Al, Lauren joined UCSF and later Meta. Lauren recently led UX research at a global Al chip startup and is currently seeking new opportunities to further her work in UX research and AI. At Meta, Lauren led UX research for 1) Privacy-Preserving ML and 2) PyTorch. Lauren has worked on NLP projects such as Word2Vec analysis of historical HIV/AIDS documents presented at TextXD, UC Berkeley 2019. Lauren is passionate about understanding technology and advocating for the people who create and consume Al. Lauren has published over 30 peer-reviewed research articles in domains including psychology, medicine, sociology, and more.” // MLOps Swag/Merch https://mlops-community.myshopify.com/ // Related Links Podcast on AI UX https://open.substack.com/pub/aistudios/p/how-to-do-user-research-for-ai-products?r=7hrv8&utm_medium=ios 2024 State of AI Infra at Scale Research Report https://ai-infrastructure.org/wp-content/uploads/2024/03/The-State-of-AI-Infrastructure-at-Scale-2024.pdf Privacy-Preserving ML UX Public Article https://www.ttclabs.net/research/how-to-help-people-understand-privacy-enhancing-technologies Homelessness research and more: https://scholar.google.com/citations?user=24zqlwkAAAAJ&hl=en Agents in Production: https://home.mlops.community/public/events/aiagentsinprod Mk.gee Si (Bonus Track): https://open.spotify.com/track/1rukW2Wxnb3GGlY0uDWIWB?si=4d5b0987ad55444a --------------- ✌️Connect With Us ✌️ ------------- Join our slack community: https://go.mlops.community/slack Follow us on Twitter: @mlopscommunity Sign up for the next meetup: https://go.mlops.community/register Catch all episodes, blogs, newsletters, and more: https://mlops.community/ Connect with Demetrios on LinkedIn: https://www.linkedin.com/in/dpbrinkm/ Connect with Lauren on LinkedIn: https://www.linkedin.com/in/laurenmichellekaplan?utm_source=share&utm_campaign=share_via&utm_content=profile&utm_medium=ios_app

On this podcast today, I am joined by three scholars: postdoctoral fellow and lecturer at Goethe University Frankfurt, Gil Hizi; assistant professor at Sun Yat-sen University, Xinyan Peng; and lecturer and researcher at the University of Ghent, Mieke Matthyssen. All three guests join me to talk about their chapters in the new book, Self-Development Ethics and Politics in China Today: A Keyword Approach (Amsterdam University Press, 2022) Self-Development Ethics and Politics in China Today takes readers on a journey into a central aspect of life in China, so-called "self-development." Twelve contributors have each written wonderfully elaborate chapters drawing on a wide range of material from practices in education, labor, and self-help as they spotlight "keywords" by which individuals make sense of their self-development journeys - including new forms of resistance to social norms. The book consists of twelve chapters and twelve keywords. In this episode, we talk about how three terms relate to self-development ethics and politics in China today: Gil Hizi joins me to talk about the Chinese term 'xinshang' (apprecation), Xinyang Peng discusses duanlian (exercise) and Mieke Matthyssen expands on the term tangping (lying flat). Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network

On this podcast today, I am joined by three scholars: postdoctoral fellow and lecturer at Goethe University Frankfurt, Gil Hizi; assistant professor at Sun Yat-sen University, Xinyan Peng; and lecturer and researcher at the University of Ghent, Mieke Matthyssen. All three guests join me to talk about their chapters in the new book, Self-Development Ethics and Politics in China Today: A Keyword Approach (Amsterdam University Press, 2022) Self-Development Ethics and Politics in China Today takes readers on a journey into a central aspect of life in China, so-called "self-development." Twelve contributors have each written wonderfully elaborate chapters drawing on a wide range of material from practices in education, labor, and self-help as they spotlight "keywords" by which individuals make sense of their self-development journeys - including new forms of resistance to social norms. The book consists of twelve chapters and twelve keywords. In this episode, we talk about how three terms relate to self-development ethics and politics in China today: Gil Hizi joins me to talk about the Chinese term 'xinshang' (apprecation), Xinyang Peng discusses duanlian (exercise) and Mieke Matthyssen expands on the term tangping (lying flat). Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/east-asian-studies

On this podcast today, I am joined by three scholars: postdoctoral fellow and lecturer at Goethe University Frankfurt, Gil Hizi; assistant professor at Sun Yat-sen University, Xinyan Peng; and lecturer and researcher at the University of Ghent, Mieke Matthyssen. All three guests join me to talk about their chapters in the new book, Self-Development Ethics and Politics in China Today: A Keyword Approach (Amsterdam University Press, 2022) Self-Development Ethics and Politics in China Today takes readers on a journey into a central aspect of life in China, so-called "self-development." Twelve contributors have each written wonderfully elaborate chapters drawing on a wide range of material from practices in education, labor, and self-help as they spotlight "keywords" by which individuals make sense of their self-development journeys - including new forms of resistance to social norms. The book consists of twelve chapters and twelve keywords. In this episode, we talk about how three terms relate to self-development ethics and politics in China today: Gil Hizi joins me to talk about the Chinese term 'xinshang' (apprecation), Xinyang Peng discusses duanlian (exercise) and Mieke Matthyssen expands on the term tangping (lying flat). Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/anthropology

On this podcast today, I am joined by three scholars: postdoctoral fellow and lecturer at Goethe University Frankfurt, Gil Hizi; assistant professor at Sun Yat-sen University, Xinyan Peng; and lecturer and researcher at the University of Ghent, Mieke Matthyssen. All three guests join me to talk about their chapters in the new book, Self-Development Ethics and Politics in China Today: A Keyword Approach (Amsterdam University Press, 2022). Self-Development Ethics and Politics in China Today takes readers on a journey into a central aspect of life in China, so-called "self-development." Twelve contributors have each written wonderfully elaborate chapters drawing on a wide range of material from practices in education, labor, and self-help as they spotlight "keywords" by which individuals make sense of their self-development journeys - including new forms of resistance to social norms. The book consists of twelve chapters and twelve keywords. In this episode, we talk about how three terms relate to self-development ethics and politics in China today: Gil Hizi joins me to talk about the Chinese term 'xinshang' (apprecation), Xinyan Peng discusses duanlian (exercise) and Mieke Matthyssen expands on the term tangping (lying flat). Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/chinese-studies

On this podcast today, I am joined by three scholars: postdoctoral fellow and lecturer at Goethe University Frankfurt, Gil Hizi; assistant professor at Sun Yat-sen University, Xinyan Peng; and lecturer and researcher at the University of Ghent, Mieke Matthyssen. All three guests join me to talk about their chapters in the new book, Self-Development Ethics and Politics in China Today: A Keyword Approach (Amsterdam University Press, 2022) Self-Development Ethics and Politics in China Today takes readers on a journey into a central aspect of life in China, so-called "self-development." Twelve contributors have each written wonderfully elaborate chapters drawing on a wide range of material from practices in education, labor, and self-help as they spotlight "keywords" by which individuals make sense of their self-development journeys - including new forms of resistance to social norms. The book consists of twelve chapters and twelve keywords. In this episode, we talk about how three terms relate to self-development ethics and politics in China today: Gil Hizi joins me to talk about the Chinese term 'xinshang' (apprecation), Xinyang Peng discusses duanlian (exercise) and Mieke Matthyssen expands on the term tangping (lying flat). Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/sociology

In this crossover episode of Guerrilla History and Rev Left, Adnan (GH) and Breht (RLR) discuss the essays of an important new book studying many aspects of the history and contemporary expression of right wing demographic obsessions, anti-immigrant and fascistic patriarchies, and the politics of Islamophobia in Europe, North America and beyond with co-editors Luiz Manuel Hernandez Aguilar and Sarah Bracke.  The book is The Politics of Replacement: Demographic Fears, Conspiracy Theories, and Race Wars, and is definitely worth picking up! Sarah Bracke is Professor of Sociology of Gender and Sexuality at the University of Amsterdam, the Netherlands. She is the principal investigator of the research project EnGendering Europe's “Muslim Question”, funded by the Dutch Research Council.  Follow her on twitter @SarahABracke Luis Manuel Hernández Aguilar is an associate researcher at the European University Viadrina, Frankfurt Oder, Germany. He holds a PhD in sociology by the Goethe-University Frankfurt am Main. His research interests focus on racism, Islamophobia and antisemitism, conspiracy theories, and the far right.

In this terrific episode of Guerrilla History, Adnan and returning guest co-host Breht discuss the essays of an important new book studying many aspects of the history and contemporary expression of right wing demographic obsessions, anti-immigrant and fascistic patriarchies, and the politics of Islamophobia in Europe, North America and beyond with co-editors Luiz Manuel Hernandez Aguilar and Sarah Bracke.  The book is The Politics of Replacement: Demographic Fears, Conspiracy Theories, and Race Wars, and is definitely worth picking up! Sarah Bracke is Professor of Sociology of Gender and Sexuality at the University of Amsterdam, the Netherlands. She is the principal investigator of the research project EnGendering Europe's “Muslim Question”, funded by the Dutch Research Council.  Follow her on twitter @SarahABracke Luis Manuel Hernández Aguilar is an associate researcher at the European University Viadrina, Frankfurt Oder, Germany. He holds a PhD in sociology by the Goethe-University Frankfurt am Main. His research interests focus on racism, Islamophobia and antisemitism, conspiracy theories, and the far right. Help support the show by signing up to our patreon, where you also will get bonus content: https://www.patreon.com/guerrillahistory   

Finally, you can easily access Bitcoin in a low-cost ETF with the VanEck Bitcoin Trust (HODL). Visit https://vaneck.com/HODLFG to learn more. VanEck Bitcoin Trust (HODL) Prospectus: https://vaneck.com/hodlprospectus/ __ Dr. Ingo Sauer of Goethe University Frankfurt joins Forward Guidance to share findings from his 360 paper on Hyperinflation in 1923 and its connection to central bank insolvency. Sauer argues that severe impairment of central bank assets, and not the printing of vast amounts of central bank liabilities (money), was the primary cause of extreme inflation witnessed 101 years ago in Germany, Austria, Hungary and Poland. Sauer inverts the causal line of exchange rate depreciation, money supply increase, and inflation, and he also shares his concern about the current state of the balance sheet of the European Central Bank (ECB). Filmed on March 5, 2024. __ Ingo Sauer's YouTube channel: https://www.youtube.com/@wissenhatkeineneigentumeri9889 Ingo Sauer's 360 page paper, “The Lessons from 1923 for the Euro Area: Enlightening the Dark Side of (In-) Solvent Central Banks' Balance Sheets”: https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4620462 Follow VanEck on Twitter https://twitter.com/vaneck_us Follow Jack Farley on Twitter https://twitter.com/JackFarley96 Follow Forward Guidance on Twitter https://twitter.com/ForwardGuidance Follow Blockworks on Twitter https://twitter.com/Blockworks_ __ Timestamps: (00:00) Introduction (00:56) Overview Of Dr. Sauer's Theory On The Ultimate Cause of Hyperinflation: Central Bank Insolvency (07:05) Dr. Sauer's Concerns About The Euro (11:22) Setting The Stage For German Hyperinflation in 1923 (14:33) The German Mark During World War I (21:40) The Assets Of The Reichsbank Increasingly Became Dominated By German Government Obligations (Not Commercial Bills / Collateral Advances / Gold) (30:03) Central Bank Insolvency (Not Money Supply Increase) Caused Hyperinflation in 1923 (34:53) VanEck Ad (36:48) Failed Attempts To Stabilize German Mark And Inflation, 1919-1922 (41:44) Reichsbank's Holdings Of German Treasury Bills Highly Correlated To (In)Solvency Factor (45:01) Explaining Sauer's "Solvency Factor" (47:29) The Mark's Short-Lived Rally In 1920 (51:10) Marker (57:09) The Mechanics Of Central Bank Insolvency (59:40) Reichsmark Insolvency Led To Depreciation Of The Mark, Which Led To Hyperinflation (01:02:34) Money Supply Did Not Cause Hyperinflation, Argues Sauer (01:15:09) The Explosion In Reichsbank's Money Supply Was Mostly Paper Cash, Not Bank Reserves (01:23:03) Reparations' Impact On German Solvency (01:27:22) The Rentenmark And The Halting Of German HyperInflation (01:30:47) Central Bank Profits and Yield Curve Dynamics (01:34:58) European Debt Crisis (2009-2015) (01:36:45) Fed As Dealer Of Last Resort, European Central Bank (ECB) As Market Maker Of Last Resort (01:38:06) ECB Is Less A Central Bank And More Of A "Headquarters" For Domestic Euro Central Banks (such as Bank of France, for example) (01:40:23) Origin Of Fed, And Clearinghouse Loan Certificates As National Currency Before The Fed (01:44:18) Why Has ECB Balance Sheet Expansion Post 2008 Coincided With Disinflation (Or Deflation), And Not Hyperinflation? (01:47:44) Sauer's Fears About The ECB And The Euro (02:00:46) The Mechanics Of Monetary Financing (02:18:32) Interest Rate Risk Is Not A Systemic Concern __ Disclaimer: Nothing discussed on Forward Guidance should be considered as investment advice. Please always do your own research & speak to a financial advisor before thinking about, thinking about putting your money into these crazy markets.

Professor Adrian Buss, Associate Professor of Finance and Academic Director of MBA Programs at the Frankfurt School of Finance & Management, discusses what makes the Frankfurt School's MBA unique, the school's admissions process, career opportunities and more. Topics Introduction (0:00) Program Highlights – What Makes the Frankfurt School MBA Unique? (4:20) Frankfurt School MBA Admissions & Scholarships – How to Improve Your Chances? (20:45) Career Opportunities after Frankfurt School – What to Know & How to Prepare (36:15) About Our Guest Dr. Adrian Buss is Associate Professor of Finance and Academic Director of MBA Programs at the Frankfurt School of Finance & Management. Prior to joining the Frankfurt School, Adrian taught as an Associate Professor of Finance at Insead for over 10 years. Adrian graduated from the University of Mannheim with a Masters of Science in Mathematics and Business Informatics before getting his PhD in Finance at Goethe University Frankfurt. Show Notes Frankfurt School of Finance & Management MBA Program Touch MBA's Summary of the Frankfurt School of Finance & Management Full-time MBA:  https://touchmba.com/frankfurt-school-finance-management-mba-program-admissions-interview-adrian-buss/ Get free, personalized school selection help at Touch MBA: https://touchmba.com

Professor Adrian Buss, Associate Professor of Finance and Academic Director of MBA Programs at the Frankfurt School of Finance & Management, discusses what makes the Frankfurt School's MBA unique, the school's admissions process, career opportunities and more. Topics Introduction (0:00) Program Highlights – What Makes the Frankfurt School MBA Unique? (4:20) Frankfurt School MBA Admissions & Scholarships – How to Improve Your Chances? (20:45) Career Opportunities after Frankfurt School – What to Know & How to Prepare (36:15) About Our Guest Dr. Adrian Buss is Associate Professor of Finance and Academic Director of MBA Programs at the Frankfurt School of Finance & Management. Prior to joining the Frankfurt School, Adrian taught as an Associate Professor of Finance at Insead for over 10 years. Adrian graduated from the University of Mannheim with a Masters of Science in Mathematics and Business Informatics before getting his PhD in Finance at Goethe University Frankfurt. Show Notes Frankfurt School of Finance & Management MBA Program Touch MBA's Summary of the Frankfurt School of Finance & Management Full-time MBA:  https://touchmba.com/frankfurt-school-finance-management-mba-program-admissions-interview-adrian-buss/ Get free, personalized school selection help at Touch MBA: https://touchmba.com

Minter Dialogue with Dr Baris Serifsoy Baris Serifsoy holds a Doctoral degree in Finance from Goethe University Frankfurt and the Diplom Kaufmann degree from the University of Regensburg, as well as an MBA degree. He has 20+ years of experience in wealth management and investment banking in 3 countries and is currently partner at GreenCap where he advises on M&A transaction in the renewable energy space. He's also coauthor with Nick Perryman of "Leadership in Wealth, Mastering the opportunities of wealth in your family, firm and society," which came out in Jan 2023. In this conversation, we discuss his book, the ways that leadership is different when you're wealthy, how to establish and keep trust, how to transmit your business, values and fortune, what constitutes and keeps happiness when you're wealthy.   If you've got comments or questions you'd like to see answered, send your email or audio file to nminterdial@gmail.com; or you can find the show notes and comment on minterdial.com. If you liked the podcast, please take a moment to rate/review the show on RateThisPodcast. Otherwise, you can find me @mdial on Twitter.

An international research team led by Goethe University Frankfurt, Germany, determined that Troodon, a dinosaur very close to modern birds, was a warm-blooded animal (an endotherm), but had a reproductive system similar to that of modern reptiles. Hosted on Acast. See acast.com/privacy for more information.

We speak with political science scholar, Nojang Khatami who is a Postdoctoral Fellow at the Justitita Center for Advanced Studies at Goethe University Frankfurt. Beginning in the fall of 2023, he will be Assistant Professor of Political Science at Fordham University. Nojang is on to talk about his Boston Review article, “The Lifeblood of Iranian Democracy: From street demonstrations to song, dance, film, and poetry, women are advancing a long legacy of struggle against authoritarianism in Iran.”

#008: In this episode, I'm interviewing Prof. Dr. Daniel Beimborn from University of Bamberg to explore how to get to the cutting edge of BPM.I have been working with Daniel on several research projects since 2009 and I really appreciate his experience. He shares his thoughts on the top BPM research topics as well as on his own research topics in the field of business process management. - An outlook to the upcoming years of the BPM development.But we also deep dive into how research can help to solve process challenges in all kinds of organizations. Therefore, he provides methodologies as well as examples on how this can be done. And he offers to support you with your BPM challenges:Call for cases: Within the episode, we open up a call for cases to find research-backed solutions to your BPM challenges. So if you have a major process-related question in your organization, feel free to contact me to connect you with Daniel for finding an appropriate solution. - And maybe, we can also discuss your case here in the New Process Podcast and share the learnings with the community.To hand in your cases, just send me a message.In addition, Daniel also shares his ideas on how to rethink processes. So a lot of input for you! Don't miss it!Today's GuestProf. Dr. Daniel BeimbornDaniel is professor for Information Systems at the University of Bamberg since 2018. Before that, he was professor for Information Systems at Frankfurt School of Finance & Management and headed the ProcessLab of Frankfurt School together with Prof. Dr. Jürgen Moormann.He was visiting Scholar at MIT and Georgia State University, he holds a diploma and a PhD from Goethe University Frankfurt and he is researching in the fields of digital transformation & innovation, outsourcing management, IT and process standardization as well as enterprise architecture management.You'll learnWhat the hot BPM research topics are and what Daniel is researching right nowHow scaled agile organizations look like, what problems Daniel sees and how to fix themWhat Daniels recommendations are to rethink processes and to get to a more human-centric BPMWhat you can do to stay at the front of the BPM developmentHow other companies partnered with researchers to solve BPM problemsWhat research can do for you to improve your BPMI hope, you enjoy this episode of the New Process Podcast and are curious to learn more in the next episode. Hit subscribe to not miss it!To provide me with feedback, please use this link:http://www.NewProcessLab.com/feedbackIf you'd like to get the links and show notes for this episode, head to:http://www.NewProcessLab.com/episode8---Follow me on LinkedIn:https://www.linkedin.com/in/mirkokloppenburg/Want to know how to start rethinking processes? Get my free checklist here: http://www.NewProcessLab.com/checklist

Ignazio Angeloni è research fellow presso il Mossavar-Rahmani Center for Business and Government all'Harvard Kennedy School e senior policy fellow presso il Leibniz Institute for Financial Research SAFE alla Goethe University Frankfurt.

WATCH: https://youtu.be/B44_ISJZMlY Menachem Fisch is Joseph and Ceil Mazer Professor Emeritus of History and Philosophy of Science, and Director of the Center for Religious and Interreligious Studies at Tel Aviv University, and Senior Fellow of the Goethe University Frankfurt's Forschungskolleg Humanwisseschaften, Bad Homburg. He has published widely on the history of 19th century British science and mathematics, on confirmation theory and rationality, on the theology of the talmudic literature, and the philosophy of talmudic legal reasoning. His recent work explores the limits of normative self-criticism, the Talmud's dispute of religiosity, the possibilities of articulating a pluralist political philosophy from within the assumptions of halakhic Judaism, the history and philosophy of scientific framework transitions, and the theo-political roots of Israel's reaction against political Zionism. EPISODE LINKS: - Menachem's Website: https://menachemfisch.academia.edu/ - Menachem's Books: https://www.amazon.com/Menachem-Fisch/e/B001H6QT1K%3Fref=dbs_a_mng_rwt_scns_share - Menachem's Publications: https://scholar.google.co.il/citations?user=1gSAA4YAAAAJ&hl=en CONNECT: - Website: https://tevinnaidu.com/podcast - Instagram: https://instagram.com/drtevinnaidu - Facebook: https://facebook.com/drtevinnaidu - Twitter: https://twitter.com/drtevinnaidu - LinkedIn: https://linkedin.com/in/drtevinnaidu TIMESTAMPS: (0:00) - Introduction (0:20) - Does science need philosophy? (& vice versa) (6:51) - Philosophical challenges of mind/brain research (14:03) - Neuroscience vs normativity (23:57) - Is it possible to predict feelings or qualia? (28:44) - Our perception of human complexity (35:32) - Karl Popper (science vs pseudoscience) (42:40) - Human consciousness and the self (47:30) - Psychiatric nosology (56:40) - Transcending normativity (1:02:07) - Teleology & religion (1:12:49) - Menachem's author recommendations (1:17:20) - Conclusion Website · YouTube

WATCH: https://youtu.be/B44_ISJZMlY Menachem Fisch is Joseph and Ceil Mazer Professor Emeritus of History and Philosophy of Science, and Director of the Center for Religious and Interreligious Studies at Tel Aviv University, and Senior Fellow of the Goethe University Frankfurt's Forschungskolleg Humanwisseschaften, Bad Homburg. He has published widely on the history of 19th century British science and mathematics, on confirmation theory and rationality, on the theology of the talmudic literature, and the philosophy of talmudic legal reasoning. His recent work explores the limits of normative self-criticism, the Talmud's dispute of religiosity, the possibilities of articulating a pluralist political philosophy from within the assumptions of halakhic Judaism, the history and philosophy of scientific framework transitions, and the theo-political roots of Israel's reaction against political Zionism. EPISODE LINKS: - Menachem's Website: https://menachemfisch.academia.edu/ - Menachem's Books: https://www.amazon.com/Menachem-Fisch/e/B001H6QT1K%3Fref=dbs_a_mng_rwt_scns_share - Menachem's Publications: https://scholar.google.co.il/citations?user=1gSAA4YAAAAJ&hl=en CONNECT: - Website: https://tevinnaidu.com/podcast - Instagram: https://instagram.com/drtevinnaidu - Facebook: https://facebook.com/drtevinnaidu - Twitter: https://twitter.com/drtevinnaidu - LinkedIn: https://linkedin.com/in/drtevinnaidu TIMESTAMPS: (0:00) - Introduction (0:20) - Does science need philosophy? (& vice versa) (6:51) - Philosophical challenges of mind/brain research (14:03) - Neuroscience vs normativity (23:57) - Is it possible to predict feelings or qualia? (28:44) - Our perception of human complexity (35:32) - Karl Popper (science vs pseudoscience) (42:40) - Human consciousness and the self (47:30) - Psychiatric nosology (56:40) - Transcending normativity (1:02:07) - Teleology & religion (1:12:49) - Menachem's author recommendations (1:17:20) - Conclusion Website · YouTube · YouTube

HIFT representa un método apropiado para mejorar el rendimiento cognitivo, específicamente la memoria de trabajo. Autor Jan Wilke Department of Sports Medicine, Goethe University Frankfurt am Main, Ginnheimer Landstraße 39, 60487, Frankfurt am Main, Germany. wilke@sport.uni-frankfurt.de. Enlace al Articulo Original en Ingles Los ejercicios aeróbicos y de resistencia (con pesas) aumentan de manera inmediata el rendimiento cognitivo (PC). El entrenamiento funcional de alta intensidad (HIFT) combina las características de ambos regímenes, pero su efecto sobre el rendimiento cognitivo no está claro. Treinta y cinco individuos sanos (26,7 ± 3,6 años, 18 mujeres) fueron asignados al azar a tres grupos. El primer grupo (HIFT) realizó un entrenamiento funcional con el máximo esfuerzo y en formato de circuito involucrando todos los grupos musculares del cuerpo, mientras que el segundo grupo (WALK) caminó al 60% de la reserva de frecuencia cardíaca. El tercer grupo permaneció físicamente inactivo leyendo un libro (CON). Antes y después del período de intervención que duro 15 minutos, el rendimiento cognitivo se evaluó con el Stroop Task, Trail Making Test y Digit Span Test. Se utilizaron ANOVA de medidas repetidas e intervalos de confianza del 95% post-hoc para detectar diferencias en los grupos y tiempo (previo y posterior a los protocolos). Se encontró una interacción significativa entre los grupos y el tiempo para la condición de conteo hacia atras de Digit Span Test (p = 0.04, IC 95%). HIFT fue superior a WALK y CON. Ademas, el análisis de la puntuación total del Digit Span Test y la condición incongruente del Stroop Task, reveló efectos pre y post (p 0.05). En conclusión, HIFT representa un método apropiado para mejorar de manera inmediata la memoria de trabajo, siendo potencialmente superior al ejercicio de tipo aeróbico moderado. El entrenamiento funcional de alta intensidad (HIFT, por sus siglas en inglés) como metodo de entrenamiento es una tendencia muy popular en el mundo del fitness, que integra el esfuerzo cardiovascular y muscular. El HIFT utiliza movimientos funcionales, multimodales y multiarticulares, por ejemplo, sentadillas, flexiones y burpees (Buckley et al., 2015). Los ejercicios funcionales utilizan todo el cuerpo y provocan un patrón de reclutamiento motor universal (Heinrich et al., 2014). El HIFT también tiene una configuración de intervalos de descanso mínimo o casi nulo (Feito, Heinrich, Butcher, & Poston, 2018). Las características mencionadas anteriormente confieren al HIFT la capacidad de mejorar la fuerza y la potencia muscular, así como de generar adaptaciones cardiovasculares anaeróbicas y aeróbicas, por lo que se ha demostrado que el HIFT desencadena efectos beneficiosos sobre el consumo de oxígeno (Vo2max), la potencia anaeróbica y fuerza muscular (Alcaraz et al., 2008; Brisebois et al., 2018; Menz et al., 2019). Además, el HIFT parece causar también beneficios neurofisiologicos. Los primeros estudios neurocientíficos asocian el HIFT con una reducción aguda del BDNF (García-Suárez et al., 2020), y curiosamente, en intervenciones más largas con un incremento del BDNF basal (Murawska-Ciałowicz et al., 2021). Además, una sesión aguda de entrenamiento del circuito HIFT mejoró la memoria a corto plazo y el control inhibitorio (Wilke et al., 2020) y una intervención de tres meses mejoró el rendimiento en el aprendizaje espacial, la separación de patrones y la capacidad de atención (Ben-Zeev, Hirsh, Weiss, Gornstein y Okun, 2020). En este estudio la intervencion consistía en una sesion de 15 ejercicios funcionales para todo el cuerpo, realizados en formato de circuito con repeticiones de 20 segundos de entrenamiento y 10 segundos de descanso. Con una duración total de 15 minutos. La selección de los ejercicios se basó en dos objetivos principales (a) la implicación de los principales grupos musculares para aumentar el consumo absoluto de oxígeno y (b) la simulación de patrones de movimiento fundamentales de uso diario (por ejemplo, sentadillas, desplantes, flexiones). El rendimiento cognitivo (CP), que puede subdividirse en funciones cognitivas de orden superior (por ejemplo, control inhibitorio o memoria de trabajo) y de orden inferior (por ejemplo, atención o tiempo de reacción). Las revisiones sistemáticas disponibles han investigado los efectos del ejercicio de tipo aeróbico, han detectando un efecto positivo en el CP incluso cuando se realiza como un único entrenamiento. Tanto el ejercicio continuo aerobico de intensidad moderada como de alta intensidad han reportado un impacto positivo en el rendimiento cognitivo. El test de Stroop consta de tres partes. En la primera y segunda sección de captación de la atención, se pide a los participantes que nombren lo más rápidamente posible las palabras escritas o los colores que aparecen en una hoja. La tercera sección representa una medida de control de la inhibición. Las palabras de colores se presentan de forma incongruente (por ejemplo, "verde" escrito en rojo o "azul escrito en amarillo"). Aquí, los participantes deben nombrar el color de la palabra mientras ignoraban las letras. Para el análisis posterior, se registra el tiempo necesario para completar la tarea. Se ha demostrado que el test de Stroop presenta una alta fiabilidad (ICC: 0,82) y consistencia interna (alfa de Cronbach: 0,93-0,97). Es el Episodio 4 Correr y Salud Mental puedes aprender mas sobre esta prueba cognitiva. El test de creación de rastros (TMT) consta de dos partes. En la parte A, los participantes deben conectar números linealmente crecientes utilizando un bolígrafo a la máxima velocidad posible. En la parte B, deben enlazar números y letras sucesivos (por ejemplo, del 1 al a y del 2 al b) de forma alterna. Al igual que en la prueba Stroop, se registra el tiempo necesario para completar la prueba. Los resultados de la prueba proporcionan una medida de detección visual/atención (TMT-A) y de flexibilidad cognitiva/memoria de trabajo (TMT-B). Se ha demostrado una alta fiabilidad (ICC: 0,81-0,86) y validez de constructo de la TMT. En la prueba de amplitud de dígitos, se realizan dos condiciones. En la primera, los participantes tienen que memorizar y repetir cantidades crecientes de números que se les leen. Al principio, deben recordar cuatro números. Si la memorización es satisfactoria, se les leen cinco números los memorizan y repiten, y asi continua subiendo la cantidad de numeros leidos que tienen que memorizar y repetir. Para cada paso, se realizan dos repeticiones y se otorgan uno o cero puntos en función del éxito de la memorización. La prueba termina si se fallan los dos ensayos. La segunda condición es idéntica a la primera, pero los números deben repetirse en orden inverso (por ejemplo, 2, 4, 7, 9 se convierte en 9, 7, 4, 2). Ambas partes de la prueba y la puntuación compuesta están relacionadas con la memoria a corto plazo y la memoria de trabajo. La prueba de amplitud de dígitos es fiable en las mediciones repetidas (r = 0,73). Los participantes del grupo WALK realizaron 15 minutos de marcha en cinta rodante al 60% de la reserva de frecuencia cardíaca individual. La RFC se determina mediante la fórmula de Karvonen (frecuencia cardíaca en reposo + ((frecuencia cardíaca máxima - frecuencia cardíaca en reposo) x intensidad). Esto es porque Los resultados de este estudio sugieren que el HIFT puede mejorar de forma inmediata el rendimiento cognitivo, concretamente la memoria a corto plazo/de trabajo y el control inhibitorio. Siendo el HIFT ligeramente superior al ejercicio aerobico continuo. Los autores mencionan que los posibles mecanismos que explican este aumento en el rendimiento cognitivo son Aumento de la perfusión cerebral tras el ejercicio de resistencia (Querido & Sheel, 2007; Ogoh & Ainslie, 2009). El aumento de los niveles séricos de cortisol y BDNF, que se ha reportado con entrenamiento de resistencia (pesas) (Tsai, et al. 2014; Yarrow, et al. 2010). Sin embargo los resultados son contradictorios en el sentido que no reportan mejoras con el ejercicio aeróbico, las cuales han sido encontradas en estudios anteriores con intensidades del 40 al 80% de la capacidad maxima de oxigeno ( Brisswalter, et al. 2002; Chang, et al. 2012). Acerca de este tema, Browne et al. 2017 sugiere que multiples factores, como el nivel de forma física y el modo de ejercicio, influyen en la relación entre el ejercicio y la cognición. Una implicación clinica práctica importante del presente estudio es que el HIFT representa una alternativa al uso de otros métodos de entrenamiento convencionales, no sólo en lo que respecta a la mejora o recuperacion de la función muscular y cardiovascular (Wilke, et al. 2020; Menz, et al. 2019), sino también cuando se pretende mejorar el rendimiento cognitivo a corto plazo. El HIFT también podría ser interesante para los individuos sedentarios con poca motivacion y tiempo limitado para hacer ejercicio, ya que se ha reportado una mayor motivacion intrinseca y mayor disfrute del ejercicio que una actividad de tipo aeróbico moderado (Wilke, et al. 2020). No se investigo la sosteníbilidad de la mejora de la PC, con evaluaciones de seguimiento adicionales, por lo que investigar los cambios 5, 10 15, 30, 60 minutos después o incluso 2, 6, 12, 24 horas después del entrenamiento a largo plazo es una tarea pendiente.No incluyó una comparación con una sesión de entrenamiento aeróbico o de resistencia con pesas de intensidad equivalente, es decir de alta intensidad. Solamente HIFT fue de alta intensidad, pero el ejercicio aeróbico estuvo en el limite superior de ejercicio de baja intensidad, con lo que la diferencia en intensidad pudo haber afectado la comparación. Alcaraz, P. E., Sánchez-Lorente, J., & Blazevich, A. J. (2008). Physical performance and cardiovascular responses to an acute bout of heavy resistance circuit training versus traditional strength training. In Journal of Strength and Conditioning Research (Vol. 22, pp. 667-671): J Strength Cond Res.Ben-Zeev, T., Hirsh, T., Weiss, I., Gornstein, M., & Okun, E. (2020). The Effects of High-intensity Functional Training (HIFT) on Spatial Learning, Visual Pattern Separation and Attention Span in Adolescents. In Frontiers in Behavioral Neuroscience (Vol. 14, pp. 577390): Frontiers Media S.A.Brisswalter, J., Collardeau, M. & René, A. Effects of acute physical exercise characteristics on cognitive performance. Sports Med. 32, 555–566 (2002).Browne, S. E. et al. Effects of acute high-intensity exercise on cognitive performance in trained individuals: a systematic review. Progr. Brain. Res. 234, 161–187 (2017).Buckley, S., Knapp, K., Lackie, A., Lewry, C., Horvey, K., Benko, C., . . . Butcher, S. (2015). Multimodal high-intensity interval training increases muscle function and metabolic performance in females. In Applied Physiology, Nutrition and Metabolism (Vol. 40, pp. 1157-1162): Appl Physiol Nutr MetabChang, Y. et al. The effects of acute exercise on cognitive performance: a meta-analysis. Brain. Res. 1453, 87–101 (2012).Feito, Y., Heinrich, K. M., Butcher, S. J., & Poston, W. S. C. (2018). High-Intensity Functional Training (HIFT): Definition and Research Implications for Improved Fitness. In Sports (Basel, Switzerland) (Vol. 6, pp. 76): MDPI AGGarcía-Suárez, P. C., Rentería, I., Moncada-Jiménez, J., Fry, A. C., & Jiménez-Maldonado, A. (2020). Acute Systemic Response Of BDNF, Lactate and Cortisol to Strenuous Exercise Modalities in Healthy Untrained Women. In Dose-response : a publication of International Hormesis Society (Vol. 18, pp. 1559325820970818): SAGE Publications Inc.Heinrich, K. M., Patel, P. M., O'Neal, J. L., & Heinrich, B. S. (2014). High-intensity compared to moderate-intensity training for exercise initiation, enjoyment, adherence, and intentions: an intervention study. BMC Public Health, 14, 789. doi:10.1186/1471-2458-14-789Menz, V. et al. Functional vs running low-volume high-intensity interval training: effects on VO2max and muscular endurance. J. Sports Sci. Med. 18, 497–504 (2019).Murawska-Ciałowicz, E., de Assis, G. G., Clemente, F. M., Feito, Y., Stastny, P., Zuwała-Jagiełło, J., . . . Wolański, P. (2021). Effect of four different forms of high intensity training on BDNF response to Wingate and Graded Exercise Test. In Scientific Reports (Vol. 11, pp. 8599): Nature Research.Ogoh, S. & Ainslie, P. N. Cerebral blood flow during exercise: mechanisms of regulation. J. Appl. Physiol. 107, 1370–1380 (2009).Querido, J. S. & Sheel, A. W. Regulation of cerebral blood flow during exercise. Sports Med. 37, 765–782 (2007).Tsai, C. et al. Executive function and endocrinological responses to acute resistance exercise. Front Behav Neurosci. 8, 283 (2014).Wilke, J. et al. Effects of high-intensity functional circuit training on motor function and sport motivation in healthy, inactive adults. Scand. J. Med. Sci. Sports 29, 144–153 (2019).Wilke, J., Stricker, V., & Usedly, S. (2020). Free-Weight Resistance Exercise Is More Effective in Enhancing Inhibitory Control than Machine-Based Training: A Randomized, Controlled Trial. In Brain sciences (Vol. 10, pp. 1-10): MDPI AG.Yarrow, J. F., White, L. J., McCoy, S. C. & Borst, S. E. Training augments resistance exercise induced elevation of circulating brain derived neurotrophic factor (BDNF). Neurosci. Lett. 26, 161–165 (2010).

In recent years we have perhaps seen a golden era of narcissistic leaders. Yet what is their real impact? And is being a narcissistic leader necessarily a bad thing? Jon Gruda is an Assistant Professor in Organisational Behaviour at Maynooth University in Ireland. He has previously held appointments at emlyon Business School (France) where he completed his Ph.D. in Management from 2012 to 2017, together with a joint Doctorate in Psychology at Goethe University Frankfurt am Main (Germany). Professor Gruda's primarily focuses on relational leadership, dark leadership traits, personality and anxiety. Recently, he was selected as one of 373 young scholars out of 20,000 applicants worldwide to attend the Lindau Nobel Prize Laureates Meeting in Economic Sciences.

The concept of revolution marks the ultimate horizon of modern politics. It is instantiated by sites of both hope and horror. Within progressive thought, “revolution” often perpetuates entrenched philosophical problems: a teleological philosophy of history, economic reductionism, and normative paternalism. At a time of resurgent uprisings, how can revolution be re-conceptualized to grasp the dynamics of social transformation and disentangle revolutionary practice from authoritarian usurpation? Eva von Redecker reconsiders critical theory's understanding of radical change in order to offer a bold new account of how revolution occurs. She argues that revolutions are not singular events but extended processes: beginning from the interstices of society, they succeed by gradually re-articulating social structures toward a new paradigm. Developing a theoretical account of social transformation, Praxis and Revolution incorporates a wide range of insights, from the Frankfurt School to queer theory and intersectionality. Its revised materialism furnishes prefigurative politics with their social conditions and performative critique with its collective force. Von Redecker revisits the French Revolution to show how change arises from struggle in everyday social practice. She illustrates the argument through rich literary examples—a ménage à trois inside a prison, a radical knitting circle, a queer affinity group, and petitioners pleading with the executioner—that forge a feminist, open-ended model of revolution. Praxis and Revolution: A Theory of Social Transformation (Columbia UP, 2021) urges readers not only to understand revolutions differently but also to situate them elsewhere: in collective contexts that aim to storm manifold Bastilles—but from within. Eva von Redecker is a German critical theorist and public philosopher, currently based at the University of Verona as the recipient of a Marie Skłodowska-Curie fellowship. She was previously a research associate at Humboldt University of Berlin and she has also taught at Goethe University Frankfurt and the New School. Lucy Duggan is a writer and translator. She is the author of the novel Tendrils (2014). Fulya Pinar is a PhD candidate in the department of Anthropology at Rutgers University. Her work focuses on alternative economies, refugee care, and migration in Turkey.

The concept of revolution marks the ultimate horizon of modern politics. It is instantiated by sites of both hope and horror. Within progressive thought, “revolution” often perpetuates entrenched philosophical problems: a teleological philosophy of history, economic reductionism, and normative paternalism. At a time of resurgent uprisings, how can revolution be re-conceptualized to grasp the dynamics of social transformation and disentangle revolutionary practice from authoritarian usurpation? Eva von Redecker reconsiders critical theory's understanding of radical change in order to offer a bold new account of how revolution occurs. She argues that revolutions are not singular events but extended processes: beginning from the interstices of society, they succeed by gradually re-articulating social structures toward a new paradigm. Developing a theoretical account of social transformation, Praxis and Revolution incorporates a wide range of insights, from the Frankfurt School to queer theory and intersectionality. Its revised materialism furnishes prefigurative politics with their social conditions and performative critique with its collective force. Von Redecker revisits the French Revolution to show how change arises from struggle in everyday social practice. She illustrates the argument through rich literary examples—a ménage à trois inside a prison, a radical knitting circle, a queer affinity group, and petitioners pleading with the executioner—that forge a feminist, open-ended model of revolution. Praxis and Revolution: A Theory of Social Transformation (Columbia UP, 2021) urges readers not only to understand revolutions differently but also to situate them elsewhere: in collective contexts that aim to storm manifold Bastilles—but from within. Eva von Redecker is a German critical theorist and public philosopher, currently based at the University of Verona as the recipient of a Marie Skłodowska-Curie fellowship. She was previously a research associate at Humboldt University of Berlin and she has also taught at Goethe University Frankfurt and the New School. Lucy Duggan is a writer and translator. She is the author of the novel Tendrils (2014). Fulya Pinar is a PhD candidate in the department of Anthropology at Rutgers University. Her work focuses on alternative economies, refugee care, and migration in Turkey. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network

The concept of revolution marks the ultimate horizon of modern politics. It is instantiated by sites of both hope and horror. Within progressive thought, “revolution” often perpetuates entrenched philosophical problems: a teleological philosophy of history, economic reductionism, and normative paternalism. At a time of resurgent uprisings, how can revolution be re-conceptualized to grasp the dynamics of social transformation and disentangle revolutionary practice from authoritarian usurpation? Eva von Redecker reconsiders critical theory's understanding of radical change in order to offer a bold new account of how revolution occurs. She argues that revolutions are not singular events but extended processes: beginning from the interstices of society, they succeed by gradually re-articulating social structures toward a new paradigm. Developing a theoretical account of social transformation, Praxis and Revolution incorporates a wide range of insights, from the Frankfurt School to queer theory and intersectionality. Its revised materialism furnishes prefigurative politics with their social conditions and performative critique with its collective force. Von Redecker revisits the French Revolution to show how change arises from struggle in everyday social practice. She illustrates the argument through rich literary examples—a ménage à trois inside a prison, a radical knitting circle, a queer affinity group, and petitioners pleading with the executioner—that forge a feminist, open-ended model of revolution. Praxis and Revolution: A Theory of Social Transformation (Columbia UP, 2021) urges readers not only to understand revolutions differently but also to situate them elsewhere: in collective contexts that aim to storm manifold Bastilles—but from within. Eva von Redecker is a German critical theorist and public philosopher, currently based at the University of Verona as the recipient of a Marie Skłodowska-Curie fellowship. She was previously a research associate at Humboldt University of Berlin and she has also taught at Goethe University Frankfurt and the New School. Lucy Duggan is a writer and translator. She is the author of the novel Tendrils (2014). Fulya Pinar is a PhD candidate in the department of Anthropology at Rutgers University. Her work focuses on alternative economies, refugee care, and migration in Turkey. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/sociology

The concept of revolution marks the ultimate horizon of modern politics. It is instantiated by sites of both hope and horror. Within progressive thought, “revolution” often perpetuates entrenched philosophical problems: a teleological philosophy of history, economic reductionism, and normative paternalism. At a time of resurgent uprisings, how can revolution be re-conceptualized to grasp the dynamics of social transformation and disentangle revolutionary practice from authoritarian usurpation? Eva von Redecker reconsiders critical theory's understanding of radical change in order to offer a bold new account of how revolution occurs. She argues that revolutions are not singular events but extended processes: beginning from the interstices of society, they succeed by gradually re-articulating social structures toward a new paradigm. Developing a theoretical account of social transformation, Praxis and Revolution incorporates a wide range of insights, from the Frankfurt School to queer theory and intersectionality. Its revised materialism furnishes prefigurative politics with their social conditions and performative critique with its collective force. Von Redecker revisits the French Revolution to show how change arises from struggle in everyday social practice. She illustrates the argument through rich literary examples—a ménage à trois inside a prison, a radical knitting circle, a queer affinity group, and petitioners pleading with the executioner—that forge a feminist, open-ended model of revolution. Praxis and Revolution: A Theory of Social Transformation (Columbia UP, 2021) urges readers not only to understand revolutions differently but also to situate them elsewhere: in collective contexts that aim to storm manifold Bastilles—but from within. Eva von Redecker is a German critical theorist and public philosopher, currently based at the University of Verona as the recipient of a Marie Skłodowska-Curie fellowship. She was previously a research associate at Humboldt University of Berlin and she has also taught at Goethe University Frankfurt and the New School. Lucy Duggan is a writer and translator. She is the author of the novel Tendrils (2014). Fulya Pinar is a PhD candidate in the department of Anthropology at Rutgers University. Her work focuses on alternative economies, refugee care, and migration in Turkey. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/political-science

The concept of revolution marks the ultimate horizon of modern politics. It is instantiated by sites of both hope and horror. Within progressive thought, “revolution” often perpetuates entrenched philosophical problems: a teleological philosophy of history, economic reductionism, and normative paternalism. At a time of resurgent uprisings, how can revolution be re-conceptualized to grasp the dynamics of social transformation and disentangle revolutionary practice from authoritarian usurpation? Eva von Redecker reconsiders critical theory's understanding of radical change in order to offer a bold new account of how revolution occurs. She argues that revolutions are not singular events but extended processes: beginning from the interstices of society, they succeed by gradually re-articulating social structures toward a new paradigm. Developing a theoretical account of social transformation, Praxis and Revolution incorporates a wide range of insights, from the Frankfurt School to queer theory and intersectionality. Its revised materialism furnishes prefigurative politics with their social conditions and performative critique with its collective force. Von Redecker revisits the French Revolution to show how change arises from struggle in everyday social practice. She illustrates the argument through rich literary examples—a ménage à trois inside a prison, a radical knitting circle, a queer affinity group, and petitioners pleading with the executioner—that forge a feminist, open-ended model of revolution. Praxis and Revolution: A Theory of Social Transformation (Columbia UP, 2021) urges readers not only to understand revolutions differently but also to situate them elsewhere: in collective contexts that aim to storm manifold Bastilles—but from within. Eva von Redecker is a German critical theorist and public philosopher, currently based at the University of Verona as the recipient of a Marie Skłodowska-Curie fellowship. She was previously a research associate at Humboldt University of Berlin and she has also taught at Goethe University Frankfurt and the New School. Lucy Duggan is a writer and translator. She is the author of the novel Tendrils (2014). Fulya Pinar is a PhD candidate in the department of Anthropology at Rutgers University. Her work focuses on alternative economies, refugee care, and migration in Turkey. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/critical-theory

The concept of revolution marks the ultimate horizon of modern politics. It is instantiated by sites of both hope and horror. Within progressive thought, “revolution” often perpetuates entrenched philosophical problems: a teleological philosophy of history, economic reductionism, and normative paternalism. At a time of resurgent uprisings, how can revolution be re-conceptualized to grasp the dynamics of social transformation and disentangle revolutionary practice from authoritarian usurpation? Eva von Redecker reconsiders critical theory's understanding of radical change in order to offer a bold new account of how revolution occurs. She argues that revolutions are not singular events but extended processes: beginning from the interstices of society, they succeed by gradually re-articulating social structures toward a new paradigm. Developing a theoretical account of social transformation, Praxis and Revolution incorporates a wide range of insights, from the Frankfurt School to queer theory and intersectionality. Its revised materialism furnishes prefigurative politics with their social conditions and performative critique with its collective force. Von Redecker revisits the French Revolution to show how change arises from struggle in everyday social practice. She illustrates the argument through rich literary examples—a ménage à trois inside a prison, a radical knitting circle, a queer affinity group, and petitioners pleading with the executioner—that forge a feminist, open-ended model of revolution. Praxis and Revolution: A Theory of Social Transformation (Columbia UP, 2021) urges readers not only to understand revolutions differently but also to situate them elsewhere: in collective contexts that aim to storm manifold Bastilles—but from within. Eva von Redecker is a German critical theorist and public philosopher, currently based at the University of Verona as the recipient of a Marie Skłodowska-Curie fellowship. She was previously a research associate at Humboldt University of Berlin and she has also taught at Goethe University Frankfurt and the New School. Lucy Duggan is a writer and translator. She is the author of the novel Tendrils (2014). Fulya Pinar is a PhD candidate in the department of Anthropology at Rutgers University. Her work focuses on alternative economies, refugee care, and migration in Turkey. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/politics-and-polemics

Whistle While You Work is a platform lead by dancers, choreographers, and artists that calls out harassment, discrimination, and violence towards women and marginalized groups particularly while at work in the arts, especially in professional dance and performance. Initiated in 2017 by writer/artist Robyn Doty and dancer/choreographer Frances Chiaverini, the platform has given Open Forums in the US and Germany; workshops at dance festivals and conferences throughout Germany and has been featured in prominent dance magazines (US, UK, EU). Frances Chiaverini was born in Pittsburgh, Pennsylvania and she is based in Frankfurt. She is a performer, activist, choreographer. She was a member of The Forsythe Company in its final seasons and has most recently performed with Adam Linder, Luisa Saraiva, Fabrice Mazliah, and Trajal Harrell. In 2017, she co-creates with Robyn Doty Whistle while you work. She is a 2019-20 Resident Fellow at NYU's Center for Ballet and the Arts. She is a choreographic consultant for Anne Imhof for works at Tate Modern, The Venice Biennale, MoMa PS. 1, Pompidou, Hamburger Bahnhof, Art Basel, and La Biennale de Montréal. Her most recent works include The Body Violent (2017, PACT) Open Carry/Concealed Carry (2018), and she most recently created a new original work called It's my house and I live here. (2019) supported by a grant from the Theaterförderung durch die Stadt Frankfurt am Main with Julia Eichten. Robyn Doty graduates in 2019 with an M.A. from the Goethe University Frankfurt where she studied and was active in Memory Studies and Transcultural Studies. In 2017 she co-organized a weeklong postcolonial studies Summer School about performance at the Goethe University Frankfurt. Since 2016 she has collaborated as a writer and dramaturg with BOHL (Frances Chiaverini and Katja Cheraneva); as a writer and dramaturg for Roderick George's kNoname dance company's DUST, FLESHLESS BEAST (Berlin); and with Katja Cheraneva on Cards Against Contemporary Dance. She has shown her own work at the Goethe University and has had her poetry and photography published by Belleville Park Pages. She is the project manager and dramaturg for Whistle while you work. She collaborated with Chiaverini for the creation of It's my house and I live here., and is Chiaverini's collaborator during their NYU CBA Fellowship in 2020. Julia Eichten danced with Camille A. Brown & Dancers, as well as Aszure Barton & Artists. Julia was a founding member of L.A. Dance Project. Based in Los Angeles, Julia continues to work with Gerard & Kelly as a performer and collaborator. Last year she assisted them on Solange's collaboration with Uniqlo, “Metratronia” as well as a month of performances at Pioneer Works(NY) in, “Clockwork.” Julia is a proud founding member of AMOC* as a dancer and choreographer. Most recently Julia danced in Carly Rae Jepsen's latest video, “Too Much” as well as working as an assistant choreographer for One Republic's yet to be released new music and video, “Wanted.” As well as premiering two new original works, “She is Her,” at the Sweat Spot and “PHRASEHXR” at Highways Performance Space. She continues her daily practice of improvisation and video art and is pleased to have premiered with collaborator Frances Chiaverini earlier this season. Contact: http://www.nobody100.com/contact Website: www.whistlewhileyouwork.art Interviewee: Frances Chiaverini, Robyn Doty, Julia Eichten Concept: Giacomo Della Marina

The concept of revolution marks the ultimate horizon of modern politics. It is instantiated by sites of both hope and horror. Within progressive thought, “revolution” often perpetuates entrenched philosophical problems: a teleological philosophy of history, economic reductionism, and normative paternalism. At a time of resurgent uprisings, how can revolution be re-conceptualized to grasp the dynamics of social transformation and disentangle revolutionary practice from authoritarian usurpation? Eva von Redecker reconsiders critical theory's understanding of radical change in order to offer a bold new account of how revolution occurs. She argues that revolutions are not singular events but extended processes: beginning from the interstices of society, they succeed by gradually re-articulating social structures toward a new paradigm. Developing a theoretical account of social transformation, Praxis and Revolution incorporates a wide range of insights, from the Frankfurt School to queer theory and intersectionality. Its revised materialism furnishes prefigurative politics with their social conditions and performative critique with its collective force. Von Redecker revisits the French Revolution to show how change arises from struggle in everyday social practice. She illustrates the argument through rich literary examples—a ménage à trois inside a prison, a radical knitting circle, a queer affinity group, and petitioners pleading with the executioner—that forge a feminist, open-ended model of revolution. Praxis and Revolution: A Theory of Social Transformation (Columbia UP, 2021) urges readers not only to understand revolutions differently but also to situate them elsewhere: in collective contexts that aim to storm manifold Bastilles—but from within. Eva von Redecker is a German critical theorist and public philosopher, currently based at the University of Verona as the recipient of a Marie Skłodowska-Curie fellowship. She was previously a research associate at Humboldt University of Berlin and she has also taught at Goethe University Frankfurt and the New School. Lucy Duggan is a writer and translator. She is the author of the novel Tendrils (2014). Fulya Pinar is a PhD candidate in the department of Anthropology at Rutgers University. Her work focuses on alternative economies, refugee care, and migration in Turkey. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/anthropology

The concept of revolution marks the ultimate horizon of modern politics. It is instantiated by sites of both hope and horror. Within progressive thought, “revolution” often perpetuates entrenched philosophical problems: a teleological philosophy of history, economic reductionism, and normative paternalism. At a time of resurgent uprisings, how can revolution be re-conceptualized to grasp the dynamics of social transformation and disentangle revolutionary practice from authoritarian usurpation? Eva von Redecker reconsiders critical theory's understanding of radical change in order to offer a bold new account of how revolution occurs. She argues that revolutions are not singular events but extended processes: beginning from the interstices of society, they succeed by gradually re-articulating social structures toward a new paradigm. Developing a theoretical account of social transformation, Praxis and Revolution incorporates a wide range of insights, from the Frankfurt School to queer theory and intersectionality. Its revised materialism furnishes prefigurative politics with their social conditions and performative critique with its collective force. Von Redecker revisits the French Revolution to show how change arises from struggle in everyday social practice. She illustrates the argument through rich literary examples—a ménage à trois inside a prison, a radical knitting circle, a queer affinity group, and petitioners pleading with the executioner—that forge a feminist, open-ended model of revolution. Praxis and Revolution: A Theory of Social Transformation (Columbia UP, 2021) urges readers not only to understand revolutions differently but also to situate them elsewhere: in collective contexts that aim to storm manifold Bastilles—but from within. Eva von Redecker is a German critical theorist and public philosopher, currently based at the University of Verona as the recipient of a Marie Skłodowska-Curie fellowship. She was previously a research associate at Humboldt University of Berlin and she has also taught at Goethe University Frankfurt and the New School. Lucy Duggan is a writer and translator. She is the author of the novel Tendrils (2014). Fulya Pinar is a PhD candidate in the department of Anthropology at Rutgers University. Her work focuses on alternative economies, refugee care, and migration in Turkey. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/book-of-the-day

When central bank policies are driven by their primary mandates, is there a case that these mandates should expand to incorporate the systemic risk that is climate change? And how will increasingly extreme climate events force policymakers' actions or limit the monetary policy space available to central bank institutions?  Emanuel Moench, Head of Research at the Deutsche Bundesbank, joins Jason Mitchell to discuss the intersection of climate change and monetary policy; what central banks are doing to integrate climate risk in their macroeconomic models; and why it's vital we continue to examine how climate change could impact the financial system. Read the full transcript of the episode here. Biography Commissioner Emanuel Moench is the Head of Research at Deutsche Bundesbank, Professor of Economics at Goethe University Frankfurt and co-chair of the recent ECB Strategy Review Occasional Paper: Climate change and monetary policy in the euro area. Prior to joining the Bundesbank, Emanuel was a Research Officer at the Federal Reserve Bank of New York. His research focuses on the intersection of macroeconomics and finance and has been published in the Journal of Finance, the Journal of Financial Economics, the Review of Financial Studies, and the Journal of Monetary Economics among others. Emanuel received the Journal of Finance's Amundi Smith Breeden First Prize in 2015 and the European Economic Association's Young Economist Award in 2008.  Learn more about your ad choices. Visit megaphone.fm/adchoices

Artificial intelligence is a fascinating--and often thoroughly misunderstood--topic, and it's making its way into the world of news. In this episode, we ask: What are the cutting-edge applications of AI in the news industry? How can we deploy it responsibly? Is AI only accessible to the largest organizations with the deepest pockets? And perhaps most importantly, what's next? Our Guest This Episode Felix M. Simon is a doctoral student at the Oxford Internet Institute (OII) and a Knight News Innovation Fellow at Columbia University's Tow Center for Digital Journalism. He also works as a research assistant at the Reuters Institute for the Study of Journalism (RISJ) and regularly writes and comments on technology, media, and politics for various international outlets. His doctoral work at the University of Oxford focuses on the implications of AI in journalism and the news industry. His broader research interests include political communication in the digital age and the changing nature of journalism and the media in the 21st century. He also takes an active interest in populism and the future of mis- and disinformation. Felix graduated with a BA in Film and Media Studies from Goethe-University Frankfurt and holds an MSc in Social Science of the Internet from the OII. He is currently a fellow at the Salzburg Global Seminar. More Resources For more on this topic, check out: What News Teams Should Know About AI-Powered Search Tools Avid and Microsoft Cloud Contact Us Questions? Comments? Cool ideas? Get in touch: makingthemedia@avid.com or @craigaw1969. Follow Avid at @avid. Credits Host: Craig Wilson Producer: Rachel Haberman Social: Wim van den Broeck Promotion: Keri Middleton, Gina Pryor, and Mary Reynolds Theme Music: Greg “Stryke” Chin

What do mountains and oceanic islands have in common? What are sky islands? And what do biodiversity, endemism and the impacts of climate change have to do with all of this? Find out in this shortened version of the keynote "Treasure Island in peril? Insights from oceanic islands and their relevance for the Alps and other mountain Systems" by Severin Irl. He is a Professor of Biogeography, Biodiversity and Ecosystem Services at the Goethe University Frankfurt. He spoke at the online bee conference "Let’s bee together", the final event of the BeeAware! project. Over the past three years, the BeeAware! project has inspired communities throughout the Alpine Arc to protect wild bees and honey bees, and thereby improving the livelihoods of these important pollinators. CIPRA implemented BeeAware! in cooperation with the community network «Alliance in the Alps» and the «Alpine Town of the Year» association. The project was funded by the German Federal Ministry for the Environment, Nature Conservation and Nuclear Safety (BMU) and other third-party sources. Further information: www.cipra.org/beeaware (de, en, fr, it, sl)

Increasingly, finance dominates the way we live our lives. Despite seeing, in recent years, growth in economies globally, more and more people are struggling to make ends meet. Inequality gaps continue to grow, and the bulk of income is concentrated among a small group. The term ‘Financialization’ has become the go-term for scholars grappling with the growth and changing face of finance and its consequences. Some explain it as the domination of financial markets and institutions over other sectors of the economy. It has been described by some as ‘wonky’. However it is understood, it is a term that is increasingly used across academic disciplines, presenting varying viewpoints and approaches, and a useful analytical lens on politics, technology, culture, society and the economy.In this episode of Between the Lines, Dinah Rajak speaks with Phil Mader and Natascha van der Zwan, about their vital new book ‘The Routledge International Handbook of Financialization’, which brings together scholars to interrogate different understandings of financialization and its impacts. With thanks to:Sarah King introduces the podcast.Sarah King produces and edits the podcast series and created the artwork.Music credit: Crypt of Insomnia/One Day in Africa (instrumental version)/Getty ImagesRelated links:To build back better we must rein in Finacialization - Phil MaderMaking Sense of Finacialization - Natascha van der ZwanPoverty Reduction of the Financialization of Poverty - Phil MaderFinancialisation and the Pension System: Lessons from the United States and the Netherlands - Natascha van der ZwanInterviewer:Dinah Rajak a Reader in anthropology and development at the University of Sussex. Her current research explores, entrepreneurship, youth employment, 'bottom of the pyramid' approaches to development and concepts of inclusive markets. She is co-founder of the Centre for New Economies of Development, author of In Good Company: An Anatomy of Corporate Social Responsibility and co-editor of The Anthropology of Corporate Social Responsibility (Berghahn 2016).Book editors:Philip Mader is a Research Fellow at the Institute of Development Studies (Brighton, UK) and program convenor of the MA in Globalisation, Business and Development. His research focuses on development and the politics of markets. His PhD from the Max Planck Institute for the Study of Societies and the University of Cologne was published as The Political Economy of Microfinance: Financializing Poverty (Palgrave, 2015) and was recognized with the Otto Hahn Medal and the German Thesis Award.Natascha van der Zwan is Assistant Professor in Public Administration at Leiden University. She does comparative and historical research on financialization and pension systems, investment rules and regulations, and pension fund capitalism. Her article ``Making Sense of Financialization'' (Socio-Economic Review, 2014) has become a key article in scholarship on financialization and is widely used in university courses. Dr Van der Zwan holds a PhD in Political Science from the New School for Social Research.Daniel Mertens is Professor of International Political Economy at the University of Osnabrück. Prior to that, he was an assistant professor at Goethe University Frankfurt and a visiting scholar at Northwestern University. He received his PhD from the Max Planck Institute for the Study of Societies and the University of Cologne. His work ranges from the politics of credit markets and banking to analyses of the modern tax state and has been published in outlets such as the Journal of European Public Policy, New Political Economy and Competition & Change. See acast.com/privacy for privacy and opt-out information.

 Perspectives on the Pandemic | "The Illusion of Evidence Based Medicine"  Leemon McHenry 10 mins   Leemon McHenry is Emeritus Professor in the Department of Philosophy , California State University, Northridge. Leemon does research in Philosophy of Science, Metaphysics and Bioethics. His current project is 'Evidence Based Medicine'.   Vitamin A for nerve cells University Medical Center Freiburg (Germany), April 1, 2021 Neuroscientists agree that a person's brain is constantly changing, rewiring itself and adapting to environmental stimuli. This is how humans learn new things and create memories. This adaptability and malleability is called plasticity. "Physicians have long suspected that remodeling processes also take place in humans at the contact points between nerve cells, i.e. directly at the synapses. Until now, however, such a coordinated adaptation of structure and function could only be demonstrated in animal experiments," says Prof. Dr. Andreas Vlachos from the Institute of Anatomy and Cell Biology at the University of Freiburg. But now Vlachos, together with Prof. Dr. Jürgen Beck, head of the Department of Neurosurgery at the University Medical Center Freiburg, has provided experimental evidence for synaptic plasticity in humans. In addition to Vlachos and Beck, the research team consists of Dr. Maximilian Lenz, Pia Kruse and Amelie Eichler from the University of Freiburg, Dr. Jakob Strähle from the University Medical Center Freiburg and colleagues from Goethe University Frankfurt. The results were presented in the scientific journal eLife. In the experiments, the team investigated whether so-called dendritic spines change when exposed to a vitamin A derivative called retionic acid. Dendritic spines are the parts of the synapse that receive, process and transmit signals during communication between neurons. As such, they play a crucial role in brain plasticity and are constantly adapting to everyday experience. For example, learning can change the number and shape of dendritic spines. However, a transformation in the number or shape of the spines is also found in diseases such as depression or dementia. The research shows that retinoic acid not only increases the size of dendritic spines, but also strengthens their ability to transmit signals between neurons. "We have concluded from our results that retinoic acids are important messengers for synaptic plasticity in the human brain. Thus, this finding contributes to the identification of key mechanisms of synaptic plasticity in the human brain and could support the development of new therapeutic strategies for brain diseases, such as depression," says Vlachos. To experimentally demonstrate that synaptic plasticity also exists in humans, the researchers use tiny samples of human cerebral cortex, which must be compulsorily removed during neurosurgical procedures for therapeutic reasons. The removed brain tissue was then treated with retinoic acid before functional and structural properties of neurons were analyzed using electrophysiological and microscopic techniques.       Study: Chemical compound in certain essential oils promotes wound healing Indiana University, April, 2021 A study from Indiana University revealed that a chemical compound in essential oils may enhance wound healing, especially when applied topically. According to co-author Sachiko Koyama, essential oils – like those from lavender, rosemary, ylang-ylang and black pepper – contain a chemical compoundcalled beta-caryophyllene. This contributes to improved wound healing, based on a murine model. “This is the first finding at the chemical-compound level showing improved wound healing in addition to changes in gene expression in the skin,” said Koyama. Beta-caryophyllene may decrease inflammation and accelerate re-epithelialization. The latter refers to the restoration of structure and function of injured tissues. During this process, epithelial cells at the wound start to migrate and cover the injured area. The researchers added that beta-caryophyllene may prevent cell death, allowing cells to survive and proliferate. “I thought maybe wound healing would be accelerated if inflammation was suppressed, stimulating an earlier switch from the inflammatory stage to the next stage,” she added. The team also noted increased gene expression of hair follicle stem cells in the treated tissue. This potentially indicate that there’s more to wound-healing activity of beta-caryophyllene than just activating genes. “It’s possibly more complicated,” she added. “Our findings suggest the involvements of some other routes in addition to CB2. I hope to clarify the mechanisms of action in the near future.” Koyama, a social neuroscientist at Indiana University, said that she wasn’t interested in studying essential oils at first, as her field of expertise was in pheromone and social status. However, her interest was sparked when she saw students working on the wound healing process in mice. She knew from experience that beta-caryophyllene can also activate cannabinoid receptor 2 (CB2), which has anti-inflammatory and analgesic properties. Healing beyond smell Most people know essential oils by way of aromatherapy. These are often used with diffusers, aromatic spritzers, inhalers, facial steamers and clay masks to bring out the aroma coming from the oil. Essential oils, in particular, may help with asthma, insomnia, fatigue and depression, among others. In the study, the researchers did not find any relationship between the sense of smell and the healing properties of beta-caryophyllene. (Related: Curcumin found to aid in the healing of skin wounds.) Koyama also offered a caveat for those looking to use essential oils for treatment, in particular, warning against the use of any essential oils. In the study, the researchers used essential oils that underwent purification processes to achieve that result. “It’s not very precise to use the essential oils themselves because there are differences,” she added. “Even if you say you used lavender, when the lavender was harvested, where it was harvested, how it was stored—all of this makes a difference in the chemical composition.” The team is also hopeful that their results will warrant further studies to determine an exact chemical composition for beta-caryophyllene that can be used to treat skin wounds. “There are many things to test before we can start using it clinically, but our results are very promising and exciting; someday in the near future, we may be able to develop a drug and drug delivery methods using the chemical compounds found in essential oils,” she added.     Exercise may help slow cognitive decline in some people with Parkinson's disease Hallym University (South Korea), April 1, 2021 For people with Parkinson's disease, problems with thinking and memory skills are among the most common nonmotor symptoms of the disease. A new study shows that exercise may help slow cognitive decline for some people with the disease. The study is published in the March 31, 2021, online issue of Neurology. Research has suggested that people with Parkinson's who have the gene variant apolipoprotein E e4, or APOE e4, may experience faster cognitive decline and earlier in the disease than people without the variant. APOE e4 is known as a genetic risk factor for Alzheimer's disease. The study looked at whether exercise could play a role in slowing cognitive decline for people with APOE e4. "Problems with thinking skills and memory can have a negative impact on people's quality of life and ability to function, so it's exciting that increasing physical activitycould have the potential to delay or prevent cognitive decline," said study author Jin-Sun Jun, M.D., of Hallym University in Seoul, Korea. The study involved 173 people with early Parkinson's disease who were on average 63 years old at the time and 59 years old when they developed the disease. A total of 27% had the APOE e4 gene variant. People reported their physical activity with a questionnaire on how much activity they had in the previous week through leisure activities such as walking or biking, household activities such as dusting or yard work and work activities for pay or as a volunteer. People took a test of their thinking skills at the beginning of the study and then one and two years later. Overall, scores at the beginning of the study averaged 26 points. For people with the APOE e4 gene variant, test scores declined by an average of 1.33 points by the end of the study compared to those without the variant. But researchers also found that greater physical activity at the start of the study lessened APOE e4-related cognitive decline two years later by an average of 0.007 points. "Additional research is needed to confirm our findings, but these results would support the use of interventions that target physical activity as a way to delay cognitive decline in people with early Parkinson's who have the APOE e4 gene variant," Jun said. A limitation of the study was that participants reported their own levels of physical activity, so there is the possibility that they would not remember their levels exactly.   Time to shift from 'food security' to 'nutrition security' to increase health and well-being Tufts and Georgetown Universities, April 1, 2021   In the 1960s, a national focus on hunger was essential to address major problems of undernutrition after World War II. In the 1990s, the nation shifted away from hunger toward "food insecurity" to better capture and address the challenges of food access and affordability. Now, a new Viewpoint article argues that today's health and equity challenges call for the U.S. to shift from "food insecurity" to "nutrition insecurity" in order to catalyze appropriate focus and policies on access not just to food but to healthy, nourishing food. The Viewpoint, by Dariush Mozaffarian of the Friedman School of Nutrition Science & Policy at Tufts University, Sheila Fleischhacker of Georgetown Law School, and José Andrés of World Central Kitchen, was published online in JAMA this week. The concept of food security focuses on access to and affordability of food that is safe, nutritious, and consistent with personal preferences. In reality, however, the "nutritious" part often has been overlooked or lost in national policies and solutions, with resulting emphasis on quantity, rather than quality, of food, say the authors. "Food is essential both for life and human dignity. Every day, I see hunger, but the hunger I see is not only for calories but for nourishing meals. With a new focus on nutrition security, we embrace a solution that nourishes people, instead of filling them with food but leaving them hungry," said Chef José Andrés, founder of World Central Kitchen. The authors define nutrition security as having consistent access to and availability and affordability of foods and beverages that promote well-being, while preventing -- and, if needed, treating -- disease. Nutrition security provides a more inclusive view that recognizes that foods must nourish all people. "'Nutrition security' incorporates all the aims of food security but with additional emphasis on the need for wholesome, healthful foods and drinks for all. COVID-19 has made clear that Americans who are most likely to be hungry are also at highest risk of diet-related diseases including obesity, diabetes, heart disease, and many cancers - a harsh legacy of inequities and structural racism in our nation. A new focus on nutrition security for all Americans will help crystallize and catalyze real solutions that provide not only food but also well-being for everyone," said first author Dariush Mozaffarian, dean of the Friedman School of Nutrition Science & Policy at Tufts University. "It's the right time for this evolution," said Sheila Fleischhacker, adjunct professor at Georgetown Law School, who has drafted food, nutrition and health legislation and campaign positions at the local, state, tribal and federal levels. "By prioritizing nutrition security, we bring together historically siloed areas - hunger and nutrition - which must be tackled together to effectively address our modern challenges of diet-related diseases and disparities in clinical care, government food and food assistance policies, public health investments, and national research." "The current approach is not sufficient," the authors write, and "traditionally marginalized minority groups as well as people living in rural and lower-income counties are most likely to experience disparities in nutrition quality, food insecurity, and corresponding diet-related diseases."     Fasting acts as diet catalyst in those with metabolic syndrome Max Delbruck Center for Molecular Medicine (Germany), March 30, 2021 One in four Germans suffers from metabolic syndrome. Several of four diseases of affluence occur at the same time in this 'deadly quartet': obesity, high blood pressure, lipid metabolism disorder and diabetes mellitus. Each of these is a risk factor for severe cardiovascular conditions, such as heart attack and stroke. Treatment aims to help patients lose weight and normalise their lipid and carbohydrate metabolism and blood pressure. In addition to exercise, doctors prescribe a low-calorie and healthy diet. Medication is often also required. However, it is not fully clear what effects nutrition has on the microbiome, immune system and health.  A research group led by Dr Sofia Forslund and Professor Dominik N. Müller from the Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) and the Experimental and Clinical Research Center (ECRC) has now examined the effect a change of diet has on people with metabolic syndrome. The ECRC is jointly run by the MDC and Charité Universitätsmedizin Berlin. "Switching to a healthy diet has a positive effect on blood pressure," says Andras Maifeld, summarising the results. "If the diet is preceded by a fast, this effect is intensified." Maifeld is the first author of the paper, which was recently published in the journal "Nature Communications". Broccoli over roast beef Dr Andreas Michalsen, Senior Consultant of the Naturopathy Department at Immanuel Hospital Berlin and Endowed Chair of Clinical Naturopathy at the Institute for Social Medicine, Epidemiology and Health Economics at Charité - Universitätsmedizin Berlin, and Professor Gustav J. Dobos, Chair of Naturopathy and Integrative Medicine at the University of Duisburg-Essen, recruited 71 volunteers with metabolic syndrome and raised systolic blood pressure. The researchers divided them into two groups at random.  Both groups followed the DASH (Dietary Approach to Stop Hypertension) diet for three months, which is designed to combat high blood pressure. This Mediterranean-style diet includes lots of fruit and vegetables, wholemeal products, nuts and pulses, fish and lean white meat. One of the two groups did not consume any solid food at all for five days before starting the DASH diet. On the basis of immunophenotyping, the scientists observed how the immune cells of the volunteers changed when they altered their diet. "The innate immune system remains stable during the fast, whereas the adaptive immune system shuts down," explains Maifeld. During this process, the number of proinflammatory T cells drops, while regulatory T cells multiply.  A Mediterranean diet is good, but to also fast is better The researchers used stool samples to examine the effects of the fast on the gut microbiome. Gut bacteria work in close contact with the immune system. Some strains of bacteria metabolise dietary fibre into anti-inflammatory short-chain fatty acids that benefit the immune system. The composition of the gut bacteria ecosystem changes drastically during fasting. Health-promoting bacteria that help to reduce blood pressure multiply. Some of these changes remain even after resumption of food intake. The following is particularly noteworthy: "Body mass index, blood pressure and the need for antihypertensive medication remained lower in the long term among volunteers who started the healthy diet with a five-day fast," explains Dominik Müller. Blood pressure normally shoots back up again when even one antihypertensive tablet is forgotten.  Blood pressure remains lower in the long term - even three months after fasting Together with scientists from the Helmholtz Centre for Infection Research and McGill University, Montreal, Canada, Forslund's working group conducted a statistical evaluation of these results using artificial intelligence to ensure that this positive effect was actually attributable to the fast and not to the medication that the volunteers were taking. They used methods from a previous study in which they had examined the influence of antihypertensive medication on the microbiome. "We were able to isolate the influence of the medication and observe that whether someone responds well to a change of diet or not depends on the individual immune response and the gut microbiome," says Forslund.  If a high-fibre, low-fat diet fails to deliver results, it is possible that there are insufficient gut bacteria in the gut microbiome that metabolise fibre into protective fatty acids. "Those who have this problem often feel that it is not worth the effort and go back to their old habits," explains the scientist. It is therefore a good idea to combine a diet with a fast. "Fasting acts as a catalyst for protective microorganisms in the gut. Health clearly improves very quickly and patients can cut back on their medication or even often stop taking tablets altogether." This could motivate them to stick to a healthy lifestyle in the long term.   Rice bran adds microbiome diversity, slows growth of colon cancer cells University of Colorado, April 5, 2021    At the American Association for Cancer Research (AACR) Annual Meeting, University of Colorado Cancer Center researchers at Colorado State University present results of a phase II clinical trial of 29 people exploring the effects of adding rice bran or navy beans to the diets of colorectal cancer survivors. After the 4-week randomized-controlled trial during which people added rice bran, navy bean powder or neither, both the rice bran and navy bean groups showed increased dietary fiber, iron, zinc, thiamin, niacin, vitamin B6, folate, and alpha-tocopherol. The rice bran group also showed increased microbiome richness and diversity. When researchers treated colorectal cancer cells with stool extracts from these groups, they saw reduced cell growth from the groups that had increased rice bran and navy bean consumption.   Previous work shows the ability of these diets to decrease colorectal cancer risk in animal models. The current trial confirms that people can eat enough bean- and rice bran-enhanced foods to promote gut health at levels shown to prevent colorectal cancer in animals. Guidelines from the American Institute for Cancer Research recommend reducing the risk of cancer by eating more vegetables, fruits, whole grains and legumes, such as beans. Ryan has established from these studies that eating a half-cup of beans and 30 grams of rice bran per day is enough to see changes in small molecules that can confer protection against colorectal cancer.   "The simple message is, 'Food is medicine,' and we are looking at how to simplify that and make it apply to our everyday lives," says study co-author Regina Brown, MD, assistant professor at the CU School of Medicine and oncologist for CUHealth.   Brown is long-time collaborator of CU Cancer Center investigator and CSU assistant professor, Elizabeth Ryan, PhD. The Ryan Lab in the CSU College of Veterinary Medicine and Biomedical Sciences studies the potential power of navy beans and rice bran to promote digestive health and to prevent metabolic alterations in obesity, heart disease and certain cancers.   "The evidence is there in animals and we can now study this in people. The question is, what are we doing to achieve adequate levels of intake of these foods?" Ryan said. "It's not enough to say 'I eat them once in a while.' That's not going to work, particularly if you are at higher risk. You have to meet a dose, just like you need a dose of a certain drug, you need to reach intake levels and consume increased amounts of these foods, and that's where people, including me, are challenged. Not everyone wants to open up a can of beans and eat them every day."   The two met about 10 years ago, when Ryan was a researcher in CSU professor Henry Thompson's Cancer Prevention Lab, and Brown was practicing medicine in Fort Collins and caring for her mother, who had uterine cancer. "It was kind of a novel partnership and had we not dug in our heels it could have died, but I told Elizabeth, 'Your work is so interesting and so valuable. We have to take this translational research from the benchtop to the clinic.' I guarantee, nine out of 10 of my patients, the first thing they ask is about their diet," Brown said.   The study's lead author is Erica Borresen, Ryan's research associate and study coordinator, who worked with colorectal cancer survivors to make sure they ate their beans and rice bran provided in meals and snacks, and that they filled out their food logs and gastrointestinal health questionnaires. It was sometimes intimate and awkward, but so is getting a colonoscopy and being treated for colorectal cancer. "Our participants donated their time and effort, and I want to make sure they understand they are appreciated," said Borresen, who earned her Master of Public Health at the Colorado School of Public Health, and plans to become a physician's assistant. "I came to realize I love the patient interaction - that's one of my favorite parts about coordinating our studies."   The next phase of Ryan's research examines effects of the cooked navy bean powder and rice bran on the colon tissue of people who have already had colorectal cancer and are at high risk for recurrence. "I really feel that there's hope in this being a practical solution to improve gut health and specifically colorectal cancer prevention," says Ryan.       Research suggests L-tryptophan supplements might help prevent impulsivity associated with psychological disorders University of California Berkeley, April 2, 2021 According to news reporting originating from Berkeley, California, research stated, “Emotion-related impulsivity, defined as the tendency to say or do things that one later regret during periods of heightened emotion, has been tied to a broad range of psychopathologies. Previous work has suggested that emotion-related impulsivity is tied to an impaired function of the serotonergic system.” Our news editors obtained a quote from the research from the University of California Berkeley, “Central serotonin synthesis relies on the intake of the essential amino acid, tryptophan and its ability to pass through the blood brain barrier. The aim of this study was to determine the association between emotion-related impulsivity and tryptophan intake. Undergraduate participants (N = 25, 16 women, 9 men) completed a self-rated measure of impulsivity (Three Factor Impulsivity Index, TFI) and daily logs of their food intake and exercise. These data were coded using the software NutriNote to evaluate intakes of tryptophan, large neutral amino acids, vitamins B6/B12, and exercise. Correlational analyses indicated that higher tryptophan intake was associated with significantly lower scores on two out of three subscales of the TFI, Pervasive Influence of Feelings scores r = -.502, p< .010, and (lack-of) Follow-Through scores, r = -.407, p< .050. Findings provide further evidence that emotion-related impulsivity is correlated to serotonergic indices, even when considering only food habits.” According to the news editors, the research concluded: “It also suggests the need for more research on whether tryptophan supplements might be beneficial for impulsive persons suffering from a psychological disorder.” This research has been peer-reviewed.         Nutritional supplementation in preconception and pregnancy linked to reduced risk of preterm birth University of Southampton (UK), March 30, 2021 Increasing evidence suggests that a mother's nutritional status at the onset of pregnancy has an important influence on the growth and development of her baby, and that a good nutritional status during pregnancy may help reduce the risk of pregnancy complications. A specific blend of nutrients and probiotics was tested in an international multicentre double blind randomized controlled trial NiPPeR (Nutritional Intervention Preconception and during Pregnancy to maintain healthy glucosE levels and offspRing health). Researchers from the international EpiGen Global Research Consortium, an academic group of clinicians and scientists including from around the world, including the University of Southampton, specifically assessed the effects of a nutritional intervention, a combination of myo-inositol, probiotics and micronutrients, consumed both before and during pregnancy, on maintaining healthy blood sugar levels in pregnancy and sustaining a healthy pregnancy and delivery. As published in the journal Diabetes Care, (Myo-inositol, Probiotics and Micronutrient Supplementation from Preconception for Glycemia in Pregnancy: the NiPPeR study involved 1,729 women from the UK, New Zealand and Singapore who were planning pregnancy—one of the largest international preconception randomized controlled trials of its type. While the study found that the intervention did not influence the mother's blood sugar levels or birthweights of the 585 babies born, the nutritional supplement decreased the incidence of preterm birth, particularly the cases associated with preterm pre-labor rupture of membranes. "Preterm delivery is a serious, common and costly public health problem worldwide that continues to increase in incidence," said Professor Keith Godfrey from the MRC Lifecourse Epidemiology Unit at the University of Southampton. "Preterm pre-labor rupture of membranes is a major cause of preterm birth. Our study presents for the first time a clinical trial of a novel non-pharmacological approach that started preconception and extended throughout pregnancy, through the innovative use of a combination of nutritional ingredients. The study findings highlight the potential value of the mix of nutrients and probiotics in reducing the risk of preterm birth and supporting a timely delivery," Professor Godfrey continued.  Associate Professor Shiao-Yng Chan, a principal investigator on the study from the Yong Loo Lin School of Medicine, National University of Singapore, deputy executive director at the Singapore Institute for Clinical Sciences, A*STAR, and Senior Consultant, Department of Obstetrics & Gynaecology, National University Hospital, commented "One of the strengths of our study is the diversity of its participants as we have involved women of multiple ethnicities from the general population across three countries, which means that the outcomes have wide relevance to women planning for pregnancy. Additionally, the study included blinded intervention and control groups, so bias is minimized." Sharing his thoughts, Professor Wayne Cutfield, principal investigator on the study from the University of Auckland, New Zealand, said, "The importance of the preconception period on maternal and offspring health is being increasingly recognized, but there are very few randomized control trials seeking to optimize preconception nutrition." Dr. Isabelle Bureau-Franz, Head of Nestlé Research, who partnered with EpiGen for this academic-led trial, says, "We are focused on discovering science-based solutions for mothers and their infants during preconception, pregnancy and while breastfeeding. The NiPPeR study is a great example of how a public-private partnership can build scientific evidence on nutritional interventions in a largely understudied group."

Is trust the make-or-break ingredient in the future of AI? This week we continue our exploration of the EU's Guidelines for Trustworthy AI and discuss the importance of trust in AI systems.In the podcast we mention the work of the Z - Inspection led by Dr. Roberto V. Zicari from the Frankfurt Big Data Lab, Goethe University Frankfurt, Germany. Below we have linked the published AI Ethics Evaluation by James Brusseau, who is part of the research team for the AI medical research mentioned. What a Philosopher Learned at an AI Ethics Evaluation 

This episode's guest is Sonia Fizek, to discuss a forthcoming book on 'delegated' and 'interpassive' play. Sonia is a digital wanderer and a ludic thinker. On a more formal note, a professor at Cologne Game Lab in media and game studies and a co-editor in chief of the Journal of Gaming and Virtual Worlds. Previously a lecturer at Abertay University, a postdoctoral researcher at the Cent­re for Di­gi­tal Cul­tu­res at Leu­pha­na Uni­ver­si­ty Lüne­burg and a guest lecturer at: Leuphana University Lüne­burg, Goethe University Frankfurt, Hamburg Media School, and Design School Berlin. “Keywords in Play” is an interview series about game research supported by Critical Distance and the Digital Games Research Association. As a joint venture, “Keywords in Play” expands Critical Distance's commitment to innovative writing and research about games while using a conversational style to bring new and diverse scholarship to a wider audience. Our goal is to highlight the work of graduate students, early career researchers and scholars from under-represented groups, backgrounds and regions. The primary inspiration comes from sociologist and critic Raymond Williams. In the Preface to his book Keywords: a vocabulary of culture and society, Williams envisaged not a static dictionary but an interactive document, encouraging readers to populate blank pages with their own keywords, notes and amendments. “Keywords in Play” follows Williams in affirming that “The significance is in the selection”, and works towards diversifying the critical terms with which we describe games and game culture.  

    Lisa Zimmermann is a Ph.D researcher in the Department Aquatic Ecotoxicology at Goethe University Frankfurt and part of the PlastX Research Group. She recently conducted a study that was published in September 2020 called: Are bioplastics and plant-based materials safer than conventional plastics? In vitro toxicity and chemical composition.        Lisa discusses what she found in the study, and the implications those findings have on our choices as a consumer when it comes to packaging. She was also featured on episode 102. Toxins In Our Plastic Products.      Further comments from Lisa after recording:    1) On the question whether plants can contain toxins: Yes, some plants naturally produce toxins, e.g., as a natural defense mechanism against predators, insects or microorganisms. In a usual balanced, healthy diet, the levels of natural toxins are well below the threshold for acute and chronic toxicity. For instance potatoes contain solanines and chaconine but especially in the sprouts and green parts, that are not eaten nor used to extract starch for bio-based plastics. Compared to these single natural compounds, in the production process of conventional and bioplastics many synthetic compounds are intentionally added (e.g. additives) or get unintentionally in the product (e.g. reaction products). Some of these might be toxic at certain concentrations.     2) On how the study transfers to human health: The results of the study cannot be transferred on humans directly. Reasons include that in vitro tests were performed. Here isolated cells are used that can give first hints of effects but don't reflect the complexity in the human body. Besides, the study examined the intrinsic chemical toxicity present in the products. In a next step, migration studies with food simulants are needed in order to identify the toxicity and chemicals migrating under real-world conditions and to estimate the human exposure to those.  Thus, the study is a first step and demonstrate that the chemical mixtures contained in the analyzed plastic product have the potential to be toxic to human health (if exposure concentrations are high enough).    

  Lisa Zimmerman is a Ph.D researcher in the Department Aquatic Ecotoxicology at Goethe University Frankfurt and  part of the PlastX Research Group.     She conducted a study called Benchmarking the in Vitro Toxicity and Chemical Composition of Plastic Consumer Products. Lisa and her team took 34 products from German supermarkets like food containers, a water bottle, and a shampoo bottle, and cut them into pieces, then used an organic solvent to determine the toxic chemicals in the plastic packaging.     Lisa discussed the findings of her study, how it was conducted, and provided us some insight into what we can do to avoid harmful substances that may be in contact with our food. We discuss bioplastics, and how they might not be as healthy as we think, and I got to ask Lisa if it's true that plastic can act as a sponge by absorbing toxins.      The Study: https://pubs.acs.org/doi/abs/10.1021/acs.est.9b02293   Plastx Group: http://www.plastx.org/https://www.facebook.com/PlastX-1735826773399950/?fref=nf

In this week’s episode I had the awesome pleasure of chatting with Dr. Misagh Habibi. Misagh is a dentist in Western Australia with an exclusive focus on implant dentistry. In this interview we cover his journey since dental school and how continuing education has really defined his career. We also discuss the state of implant education for dentists and how the PGCert program that he is running at The Implant Institute is designed to provide a comprehensive option for dentists looking for a deep understanding of implant dentistry. About Dr. Misagh Habibi Dr Misagh Habibi qualified as a dentist from the University of Western Australia in 1999. Subsequently he gained a Graduate Diploma in intravenous sedation and pain control from Sydney University and a Masters degree (MSc) in oral implantology from Goethe University (Frankfurt). He has also been awarded a Fellowship and Board Certified Diplomate Status of the International Congress of Oral Implantologists. Dr Habibi is Director of The Implant Institute and Australian Program Director for the PGCert and PGDip programs of the Cambridge Academy of Dental Implantology (UK). He is a Tutor and Supervisor of MSc (Oral Implantology) students for Goethe University Frankfurt. Previously he has served multiple years as Honorary Clinical Consultant and Consultant Sedationist for UWA Dental School/Oral Health Centre of WA. Misagh has been involved in multiple clinical studies and is currently a PhD candidate at the University of Western Australia developing and investigating an innovative biomaterial concept for application in bone grafting and implant dentistry. Misagh has performed several thousand implant procedures and administered several thousand hours of intravenous sedation. He has experience with multiple implant systems, techniques and hard and soft tissue grafting modalities. Misagh has been running his implantology-focussed clinic for 12 years, which is also an Accredited Academic Clinic of Goethe University’s MOI (MSc) program, and WA’s All On 4 Clinic. Most of his clinical time is dedicated to complex cases, including full arch immediate reconstruction of terminal dentitions and compromised jaws, including conventional (tissue preservation and grafting), All-on-4/All-on-X, and atrophic jaw grafting, zygoma and pterygoid solutions. Misagh has lectured nationally and internationally for various organisations and brings a diverse implantology experience to his teaching, sharing real life experience rich in clinical cases and illustrations. He believes in a “big picture and small details” philosophy of education which comes across in his interactive and practically oriented courses.   About the Implant Institute The Postgraduate Certificate in Dental Implantology is a formal postgraduate qualification from the Cambridge Academy of Dental Implantology (CAofDI), approved by the globally recognised regulated UK awarding body, EduQual. It allows for continuation of studies toward our Postgraduate Diploma in Dental Implantology in Year 2. Successful completion of the program allows use of the letters PGCert (Dent Imp) or PGDip (Dent Imp) after your name. This blended learning program provides training aimed at dentists who wish to undertake comprehensive didactic learning consisting of theoretical, practical and clinical components, with little, moderate or no level of previous experience in dental implantology. The PGCert program comprises of 3 elements and an optional 4th learning This blended learning program provides training aimed at dentists who wish to undertake comprehensive didactic learning consisting of theoretical, practical and clinical components, with little, moderate or no level of previous experience in dental implantology. The PGCert program comprises of 3 elements and an optional 4th learning module: 1.  Online Theory Module - 13th January 2020 - 28th June 2020; 2.  Practical Skills Week Module - July 2020: 13th-18th July (possible second stream 20th-25th July); 3.  Clinical Cases Module - August 2020 onwards; *4.  Optional Extracurricular Modules (not towards PGCert). WITH THE PGCERT PROGRAM COMMENCING IN JANUARY 2020, ENROLMENTS ARE CLOSING SOON. Check our www.theimplantinstitute.com.au or email info@theimplantinstitute.com.au for more info.   About the Sponsor: Are you looking for a hands on course to complement your current CPD plan?  Henry Schein runs over 150 CPD courses every year.  Visit their website www.henryschein.com.au to view the current offering.  Their complete offering ranges from endodontics, orthodontics, surgical as well as infection control and much more! Use code PODCAST for a 5% discount on all Henry Schein run courses.      Podcast Details: As always if you have been enjoying listening to the Noobie Dentist Podcast, please pass along the podcast to your friends, classmates and colleagues. If you haven’t already head over to iTunes and give the show a 5 star rating and if you have some time leave a review! The NoobieDentist podcast is now available on Spotify, youtube, noobiedentist.com, apple podcast app, stitcher and any other podcast apps out there!http://www.noobiedentist.com @noobiedentist on Instagramhttps://www.youtube.com/channel/UCu90HU1-gBJK1Pkz61OQaQA Noobie Dentist Study Club on Facebookhttps://www.facebook.com/groups/noobiedentistSC/              

Dr Carolyn Lam:                Welcome to Circulation on The Run, your weekly podcast summary and backstage pass to the journal and it's editors. I'm Dr Carolyn Lam, Associate Editor from the National Heart Center and Duke National University of Singapore. We will be discussing accelerated diagnostic protocols for chest pain, a very, very important issue in Cardiology with very important new safety and effectiveness data on one such protocol provided in our feature paper this week. Coming right up after these summaries.                                                 Our first original paper this week identifies a new link between specific gut bacteria and atherosclerosis. Co-First authors, Dr Yoshida and Emoto, corresponding author, Dr Yamashita, from Kobe University Graduate School of Medicine, and colleagues recruited patients with coronary artery disease and controls without coronary artery disease but with coronary risk factors. They then compared gut microbial composition using 16S ribosomal RNA gene sequencing in fecal samples. Subsequently, they used atherosclerosis prone mice to study the mechanisms underlying the relationship between such species and atherosclerosis. Their analysis of gut microbial profile in patients with coronary artery disease showed a relative depletion of bacteroides vulgatus and bacteroides dorei compared to controls with coronary risk factors. Gavage with live bacteroides vulgatus and bacteroides dorei decreased fecal and plasma lipopolysaccharide levels and protected against atherosclerosis in apoE deficient mice. Fecal lipopolysaccharide levels in patients with coronary artery disease were significantly higher compared to controls. These findings suggest that bacteroides treatment may serve as a novel and effective therapeutic strategy for suppressing lipopolysaccharide-induced inflammatory response in coronary artery disease.                                                 The next paper identified a potential novel molecular target in the treatment of myocarditis. Co-First authors, Dr Chen and Zeng, Co-Corresponding authors, Dr Song from Fuwai Hospital in Beijing, and Dr Yang from Shenzhen University School of Medicine, and their colleagues aim to elucidate the role of BCL2 Like protein 12 in the pathogenesis of biased T Helper-2 response in myocarditis. Using a combination of mouse models of myocardial inflammation and human hearts from patients undergoing heart transplantation, the authors found that CD4 positive T-cells isolated from hearts in myocarditis at the end stage of heart failure expressed high levels of BCL2 Like protein 12, which was required for the development of aberrant T Helper 2 polarization in the heart. Thus, BCL2 Like protein 12 may be a novel target in the treatment of myocarditis, as well as other T Helper 2 biased inflammatory processes.                                                 Could vaccination against LDL be a way to prevent atherosclerosis? Well, the next paper brings us one step closer to this dream. First author, Dr Gisterå, corresponding author, Dr Hansson from Karolinska School University Hospital and colleagues developed T-cell receptor transgenic mice to study LDL autoimmunity in a humanized hypercholesterolemic mouse model of atherosclerosis. A strong T-cell dependent E-cell response was induced by ODL leading to production of anti-LDL IgG antibodies that enhanced LDL clearance and ameliorated atherosclerosis. Results show that anti-LDL immuno-reactivity evoked three atheroprotective mechanisms, namely 1) antibody-dependent LDL clearance, 2) increased cholesterol excretion, and 3) reduced vascular inflammation, thus targeting LDL-reactive T cells may enhance atheroprotective immunity, and vaccination against LDL components may be an attractive way to prevent atherosclerosis.                                                 MicroRNAs regulate nearly all biological pathways and dysregulation of MicroRNAs is known to lead to disease progression. However, are there cell type specific effects of MicroRNAs in the heart? Co-First authors, Drs Rogg and Abplanalp, corresponding author, Dr Dimmeler from Goethe University Frankfurt, and colleagues assessed MicroRNA target regulation using MicroRNA 92a3p as an example. Their data showed that MicroRNAs have cell type specific effects in vivo which would be overlooked in bulk RNA sequencing. Analysis of MicroRNA targets in cell subsets disclosed a novel function of MicroRNA 92a3p in endothelial cell autophagy and cardiomyocyte metabolism. These findings may have clinical applications for the fine tuning of autophagy and metabolism to mitigate tissue damage in patients with cardiac disease.                                                 The next paper establishes a mechanism by which cardiac inflammation may be initiated in response to hemodynamic stress, but in the absence of significant cardiomyocyte cell death. Co-First authors, Drs Suetomi and Willeford, Co-Corresponding authors, Drs Brown and Miyamoto from University of California San Diego, and their colleagues used conditional cardiomyocyte-specific calcium calmodulin-regulated kinase Delta all CaM kinase II Delta knockout mice to demonstrate that cardiomyocytes generate inflammatory chemokines and cytokines and are the initial site of NLRP3 inflammasome activation. They further identified a causal role for CaM-Kinase II Delta-mediated activation of NLRP3 inflammasome and inflammatory responses in macrophage recruitment, cardiac fibrosis, and development of heart failure induced by pressure overload. Their elegant mouse experiments revealed sites and mechanisms of proinflammatory gene and inflammasome activation within cardiomyocytes which could serve as targets for early intervention or disease prevention.                                                 Are there different metabolomic effects between PCSK9 inhibitors and statins? First author, Dr Sliz, Corresponding Author, Dr Würtz from Nightingale Health Limited in Helsinki, Finland, and their colleagues quantify 228 circulating metabolic measures by Nuclear Magnetic Resonance Spectroscopy for over 5300 individuals in the PROSPER Trial at six months post randomization. The corresponding metabolic measures were also analyzed in eight population cohorts, including more than 72,000 individuals using a specific PCSK9 inhibitor SNP as an unfounded proxy to mimic the therapeutic effects of PCSK9 inhibitors. Scaled to an equivalent lowering of LDL cholesterol the effects of genetic inhibition of PCSK9 on these 228 metabolic markers were generally consistent with those of statin therapy. Alterations of lipoprotein lipid composition and fatty acid distributions were also similar. However, discrepancies were observed for very low-density lipoprotein or VLDL lipid measures where genetic inhibition of PCSK9 had weaker effects on lowering VLDL cholesterol compared with statin therapy. Genetic inhibition of PCSK9 showed no significant effects on amino acids, ketones, or a marker of inflammation, where a statin treatment weekly lowered this marker of inflammation. Thus, if VLDL lipids have an independent causal effect on cardiovascular disease risk, the observed discrepancy on VLDL lipid lowering could contribute to differences in cardiovascular risk reduction between statins and PCSK9 inhibitors for an equivalent reduction in LDL cholesterol. Moreover, these results exemplify the utility of large-scale metabolomic profiling with genetics and randomized trial data to uncover potential molecular differences between related therapeutics.                                                 The final original paper this week demonstrates a novel biomarker discovery paradigm to identify candidate biomarkers of cardiovascular and other diseases. Co-First authors, Dr Mosley and Benson, co-corresponding authors, Dr Wang from Vanderbilt University Medical Center and Gerszten from Beth Israel Deaconess Medical Center, and their colleagues employed a virtual proteomic approach linking genetically-predicted protein levels to clinical diagnosis in more than 40,000 individuals. They used genome-wide association data from the Framingham Heart Study to construct genetic predictors for more than 1100 plasma protein levels. They validated the genetic predictors for 268 proteins and used them to compute predicted protein levels in more than 41,000 genotyped individuals in the eMerge Cohort. They tested associations for each predicted protein with more than 1100 clinical phenotypes. These associations were validated using directly-measured protein levels and either LDL cholesterol or subclinical atherosclerosis in the Malmo Diet and Cancer study. Using this virtual biomarker strategy the authors identified CLC1B and PDGFR Beta as potential circulating biomarkers of atherosclerosis and validated them in an epidemiologic cohort. Thus, these results demonstrate that a virtual biomarker study may efficiently identify potential biomarker disease associations, and that wraps it up for our summaries. Now for our feature discussion.                                                 Accelerated diagnostic protocols for testing are used everywhere. They're designed to improve the quality and value of chest pain risk stratification. However, many of them lack sufficient prospective safety and effectiveness data. We're so pleased to have a paper today that provides such important data on one of these accelerated diagnostic protocols for chest pain, and it's the HEART Pathway. To discuss this, I've got the corresponding author of today's featured paper, Dr Simon Mahler from Wake Forest School of Medicine, as well as our Associate Editor, Dr Deb Diercks from UT Southwestern. Simon, could you start by just telling us, what is the HEART Pathway? Dr Simon Mahler:             Sure. Yeah, it's an accelerated diagnostic protocol. It's based on an accelerated diagnostic protocol called the HEART Score. We use a modified version of the Heart Score. We actually use a HEAR score, and that stands for the history, EKG, Age, and risk factors. That is combined with two troponin measures at 0 and 3 hours. We also factor in whether or not the patient has had prior coronary artery disease or has an acute ischemic EKG. So, to be low-risk you have to have a HEAR score of 0-3. HEAR is an acronym. You get points for each of those categories. If you have less than 3 points that's a low score. You have to have a low score, a non-ischemic EKG, no history of prior coronary disease, and two troponins less than a 99th percentile at 0 and 3 hours to be considered low risk and recommended for early discharge. If you don't meet any of those criteria then you are considered non-low risk and appropriate for further in-hospital evaluation. Dr Carolyn Lam:                That's great. Could you just tell us what you did to give us some real-world safety and effectiveness data on this. Dr Simon Mahler:             Yeah, so we had done a single-site randomized controlled trial. That was published in 2015 in Circulation: Quality and Outcomes, and really showed some promising results. We received some funding to do an implementation trial. So, this is the results of our implementation study. It's a before and after study. What we did was we sought to implement a HEART Pathway as a clinical decision support tool, integrated fully into our electronic medical record so that when providers see the patient with chest pain and order a troponin they interact with a HEART Pathway tool that guides them through the HEART Pathway risk assessment and then provides real-time decision support regarding their treatment and disposition decisions based on whether or not the patient has a low-risk assessment or a non-low-risk assessment. The design of the study was we collected data on all patients with chest pain and troponin order for one year while we worked on how we were gonna build this tool and embed it, and then we had three month watching period where we built the tool into the electronic health record across our three sites. Then, we had one year where we were post implementation where we collected data and looking at the difference in outcomes, particularly looking at both safety and utilization outcomes before and after use of the HEART Pathway. Dr Carolyn Lam:                That's just such a clever design. Just give us a summary of the results before I ask Deb to chime in here. Dr Simon Mahler:             There's a few really important things that we found. Probably the most important thing was the safety data that came out of this study. We had some good safety signals on prior studies. They didn't have enough sample size to really have a good precision around the safety point estimate, so in this study we had over 4000 patients in our post-implementation cohort, and about 31%, 30.7%, of those patients were classified as low-risk by the HEART Pathway. Among those patients that were classified by low-risk, the rate of death and MI, the composite outcome at 30 days, was 0.4%. Typically for these accelerated diagnostic protocols we want them to have an adverse cardiac event rate less than 1%, so a finding of 0.4% with a confidence in our role that doesn't extend beyond 1% that was a really important finding that really confirms the safety of this strategy.                                                 The other thing that we found which was interesting was that the use of the HEART Pathway was actually associated with detecting more myocardial infarctions during the index visit, which means that possibly the HEART Pathway use improved the recognition of those patients that were presenting with MIs. It's possible that without using the HEART Pathway some of those cases may have been missed. Finally, we were able to demonstrate that use of the HEART Pathway as a clinical decision support tool was able to decrease hospitalizations and some other utilization metrics such as stress testing and possible length of stay. Dr Carolyn Lam:                Oh, that's awesome, Simon. I said it earlier. I'm gonna say it again. Thank you so much for publishing this wonderful work with Circulation. I really think that implementation, science, and decision support tools you've got that all in this paper, just beyond even the actual topic. Deb, take us behind the scenes a little bit with how we reacted as editors to this paper, please. Dr Deb Diercks:                 Well, I think that overall, we were really excited about this paper. It really does add a real, real context to something we were really discussing and wondering about. I think one of the great things about the implementation, and Simon, please comment on this, is the diversity of the places that you actually used this in. I mean, most of us when we look at papers there's always a fear that it won't be able to be generalized to real-world practices. Correct me if I'm wrong, but you really applied it to just a wide variety of Emergency Departments that really support that this could be used anywhere. Dr Simon Mahler:             Yeah, I think that's a really important point, that we did this across our system so that included a large academic busy Emergency Department that sees over 100,000 patients per year, all the way, basically to a smaller 12,000 per year, essentially almost a free-standing Emergency Department at the time that we started our study; it now has inpatient bed capacity, and then a suburban/rural hospital, as well, with about 30,000 patient visits per year. We extended beyond kind of the typical kind of comfort zone of large academic centers and into smaller community Emergency Departments as well. Dr Deb Diercks:                 One of the things that this manuscript nicely articulated is that you kind of break it into the HEAR and then the troponin. Dr Simon Mahler:             Right. Dr Deb Diercks:                 Things change in the US with troponin. How do you think that's gonna impact how you guys apply this Pathway in the future? Dr Simon Mahler:             It's a big topic of discussion right now, what to do with these Pathways. Are these Pathways still needed with the availability now of high-sensitivity troponins in the United States? I think that for many years as we've kind of followed data coming out of Europe we've been anxiously awaiting the arrival of these tests in the U.S., and there's a lot we can learn from the European data so far. Most of that data suggests that the high-density troponins are best used still in the context of a Pathway or an accelerated diagnostic protocol.                                                 I think that this particular study was conducted just using contemporary troponins, particularly given the time frame of the study in which we were accruing patients from 2013 through 2016, but I think it's still gonna be highly relevant, because I think that best practices are gonna still require us to use some sort of structured framework with high-sensitivity troponins. Now, it does remain to be seen a little bit what the best Pathway is gonna be to incorporate that. My take on this is that I believe that clinical decisions support tools or decision aids integrated with high-sensitivity troponins is going to be the best way to go. I'm a little bit skeptical about troponin-only approaches. Dr Deb Diercks:                 That's a great summary. I don't think it's time to throw out all the value of that risk stratification tool, and I think your study showed that how it can easily be incorporated into what we do in a manner that doesn't really negatively impact the work flow, which I think is so important. Dr Simon Mahler:             You know, we did a smaller study where we looked at the performance of the HEART Pathway with high-sensitivity assays. We studied it with both the Roche troponin high-sensitivity troponin T and the Abbott high-sensitivity I, and at the 99th percentile it actually made very little difference in terms of the performance of the HEART Pathway. What the potential advantages of incorporating high-sensitivity assays is that you probably no longer need a 0 and 3 hours, evaluation can be condensed. I think there's a lot of really interesting questions that availability of high-sensitivity troponins has created, and I think that there's gonna be a lot of emerging evidence over the next few years about new Pathways, and what are the best ways to fully take advantage of these higher-sensitive assays because, frankly, most of the decision aids that are currently in use they were developed using contemporary troponins, and they may not fully take advantage of high-sensitivity troponins. We may see modifications of our Pathway, and it will interesting to see kind of how things evolve as we study the impact of high-sensitivity troponin. Dr Carolyn Lam:                Wow, exciting work ahead. Just one last question regarding the future. So, you followed up the patients in your study for 30 days. Am I wrong? Any plans to follow them up longer, and do you think such data are needed? Dr Simon Mahler:             Yeah, we actually followed them for a year. Our primary analysis was through 30 days, and so we do have one-year data on all of our patients, and so we'll be doing a secondary analysis looking out to a year. Yeah, you can look forward to that coming up hopefully in the next six months or so. Dr Carolyn Lam:                That is awesome. Thank you so much, Simon. Thank you so much, Deb. Thank you, listeners, for joining us today. You've been listening to Circulation on the Run. Don't forget to tune in again next week. This program is copyright American Heart Association 2018.

Dr. Steffen Hohl studied medicine and dentistry at the Goethe University Frankfurt in Germany. He began his clinical training at Harvard Medical School in Boston, MA, where he trained in emergency medicine, plastic surgery and neurosurgery at Boston‘s Massachusetts General Hospital and the Brigham and Women‘s Hospital. He subsequently trained as a dentist for oral and maxillofacial surgery at the University of Cologne and the interdisciplinary trauma center in Dortmund, qualifying four years later as a consultant for oral and maxillofacial surgery and a dentist specializing in oral surgery. In 2005, Dr. Hohl established die Zahnerei, his practice for oral and maxillofacial surgery and aesthetic dentistry in Buxtehude in northern Germany, where he is the clinical director. Die Zahnerei is also a training and professional development center for implantology and aesthetic dentistry. Steffen Hohl is the creator of the smile changer concept. He has also developed the world‘s first “soft sedation“ process, called Schlaf-schön-Sedierung, that he has been using regularly in his practice since 2014. With more than twenty years of experience in dental implantology, soft tissue management, and implant restoration, he has brought together his own proprietary treatment concept known as the SOAP success concept. Dr. Hohl gives regular lectures both in Germany and internationally. His special interests are the smile changer concept, SOAP success concept, immediate implantation and immediate loading. Other practice areas include aesthetic soft tissue management and plastic periodontal surgery. Another focus is the 3D planning and 3D reconstruction of the peri-implant region.

Dominik M. Müller speaks at the Southeast Asia Seminar. In this talk, Dominik Mueller will present the conceptual framework of a newly established collaborative research project studying "The Bureaucratisation of Islam and its Socio-Legal Dimensions in Southeast Asia". It investigates contemporary dynamics of Islamic bureaucratisation with an analytic focus on the state's exercise of classificatory power and its workings on the micro-level. The project views the bureaucratisation of Islam in Southeast Asia not just as an empirical fact to be examined in singular national contexts, but aims at theorising its underlying patterns from a comparative perspective. Dominik M. Mueller is Director of the Junior Research Group "The Bureaucratisation of Islam and its Socio-Legal Dimensions in Southeast Asia" at the Max Planck Institute for Social Anthropology, funded by the German Research Foundation’s prestigious Emmy Noether Programme. After obtaining his PhD at Goethe-University Frankfurt in 2012, he was a Post-Doctoral Fellow in Political and Legal Anthropology in Frankfurt (2012-2016) and held visiting positions at Stanford University (2013), the University of Brunei Darussalam (2014), St Antony's College, University of Oxford (2015), and the National University of Singapore (2016).

Sprang argues for a progressiveness in Yates in regards to Shakespeare (that is not merely limited to the occult) in her understanding in the use of images, especially pertaining to memory. He re-evaluates Yates’ observation that the advent of Ramist thinking has had an effect on the way Shakespeare. He links this view to cognitive approaches to Shakespeare and images. Felix Sprang has worked mainly on the intersection of literature and the ‘arts and sciences’ in early modern England as well as on the connection between literature and science across all literary periods. He is also interested in the aesthetics of literary texts and the methods derived from the project “Kulturwissenschaft”, in particular the strand devised by Aby Warburg and Ernst Cassirer. Felix Sprang has studied English, Biology, Philosophy and Paedagogics at the Goethe University Frankfurt and the University of Hamburg, and has received his PhD from the University of Hamburg with a dissertation that probes into literary reflections of scientific thought in early modern London. That book was largely conceived as Aby Warburg Scholar at the Warburg Institute, University of London. Having taught at the HU Berlin and the LMU Munich, he is now teaching English Literature at the University of Siegen. The conference Frances Yates: The Art of Memory was held on April 30, 2016 at the Rose Theatre, Kingston. The session was chaired by Edward Chaney. Recorded by Anna Rajala and Timo Uotinen. More at: kingstonshakespeareseminar.wordpress.com/

Neuroaesthetics | Symposium Symposium im ZKM | Zentrum für Kunst und Medientechnologie, 22.-24. November 2012 In Kooperation und mit Unterstützung der Gemeinnützigen Hertie-Stiftung. Rising interest in theories of embodiment highlight the need to better understand the relation of action and conscious perception. Specifically, we investigate the concept that the quality of sensory awareness is determined by systematic change of afferent signals resulting from behaviour and knowledge thereof. The feelSpace belt provides qualitatively new sensory signals, relating the orientation of the subject to magnetic north. The resulting transformation laws, linking change of sensory signals and actions by the subject, establish sensorimotor contingencies. The study demonstrates that the signals provided by the feelSpace belt improve behavioural performance, influence physiologic reactions and lead to qualitative changes in perceptual effects. These results provide evidence for a causal role of sensorimotor contingencies in perceptual awareness. In a follow-up we study sensory enhancement in a congenitally blind subject. Consistent with an earlier report improved behavioural performance and perceptual effects could be induced. However, unsupervised training by itself was not sufficient, and explicit instructions and training was necessary to ground the qualitatively new signals and provide associations with the available senses. A unified framework is presented that describes the interaction of sensory and motor systems as an interaction optimizing the predictability of sensory representations in the light of the behavioural repertoire. In summary, the presented experiments argue for a constitutive role of action in the formation of perception, although in some aspects it was dependent on available cognitive resources. Dr. Peter König is Professor of Neurobiopsychology at the University of Os- nabrück and director of the Institute of Cognitive Science. He studied physics and medicine at the University of Bonn. From 1978 to 1994 he was scholarship holder and research assistant at the Max Planck Institute for Brain Research in Frankfurt am Main in the department of neurophysiology, and from 1995 to 1997 Senior Fellow at The Neurosciences Institute in La Jolla, California. This was followed by his Habilitation thesis at the Goethe University Frankfurt and the conferring of the title of private lecturer. From 1997 to 2003 he worked at the Institute of Neuroinformatics at the ETH Zurich as assistant professor. In 2009, he founded WhiteMatter Labs GmbH of which he is the scientific director. Since 2001, he is visiting professor at the Department of Neurophysiology and Pathophysiology of the University Medical Center Hamburg-Eppendorf.