Podcasts about plasmapheresis

Doctor's Farmacy with Mark Hyman, MD: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- Cutting-edge medical advances are unlocking new ways to slow aging and enhance health. Plasmapheresis removes harmful inflammatory molecules, toxins, and cellular waste from plasma, helping to reduce biological aging and improve resilience. Muse cells, a powerful form of stem cell therapy, show promise in regenerating tissue and treating complex conditions like ALS and stroke. And peptides—small, naturally occurring signaling molecules—support healing, immune balance, and cellular repair, offering practical tools for longevity and optimized health. In this episode, I talk with Dr. Darshan Shah, Dr. Adeel Khan, and Dr. Edwin Lee about medical advancements that are the ultimate longevity biohacks. Dr. Darshan Shah is a board-certified surgeon, longevity medicine expert, author, and founder of Next Health—the world's largest Health Optimization and Longevity clinic. He has performed over 20,000 surgical procedures and advised thousands on extending healthspan and lifespan. A prodigy in medicine, Dr. Shah earned his MD at 21 and trained at the Mayo Clinic. He has since launched multiple health ventures, authored a book, and patented medical devices. Committed to ongoing learning, he holds alumni status at Harvard Business School and Singularity University. Dr. Shah is a sought-after speaker on health and longevity. Dr. Adeel Khan, M.D. is a cell and gene therapy specialist with a visionary approach that is changing the way we perceive healthcare worldwide. Khan has cemented his reputation as a regenerative medicine expert and a driven entrepreneur. Dr. Edwin Lee is a board-certified endocrinologist, author, and international speaker specializing in hormonal balance, regenerative, and functional medicine. He founded the Institute for Hormonal Balance in Orlando in 2008 and completed fellowships in Critical Care and Endocrinology at the University of Pittsburgh. Dr. Lee is the lead investigator of an IRB-approved senolytic study exploring compounds like Dasatinib, Quercetin, and Fisetin, and recently published the first human trial using BPC157 for knee pain. He is an assistant professor at the University of Central Florida College of Medicine, co-founder of the Clinical Peptide Society, and founder of SavePeptides.org. His latest book is The Fountain of Youth with Peptides. This episode is brought to you by BIOptimizers. Head to bioptimizers.com/hyman and use code HYMAN10 to save 10%. Full-length episodes can be found here: This Breakthrough Blood Therapy Could Add Years To Your LifeStem Cells & Peptides: The Secret to Reversing Chronic Pain and Aging?How Peptides Enhance Healing and Longevity

Cutting-edge medical advances are unlocking new ways to slow aging and enhance health. Plasmapheresis removes harmful inflammatory molecules, toxins, and cellular waste from plasma, helping to reduce biological aging and improve resilience. Muse cells, a powerful form of stem cell therapy, show promise in regenerating tissue and treating complex conditions like ALS and stroke. And peptides—small, naturally occurring signaling molecules—support healing, immune balance, and cellular repair, offering practical tools for longevity and optimized health. In this episode, I talk with Dr. Darshan Shah, Dr. Adeel Khan, and Dr. Edwin Lee about medical advancements that are the ultimate longevity biohacks. Dr. Darshan Shah is a board-certified surgeon, longevity medicine expert, author, and founder of Next Health—the world's largest Health Optimization and Longevity clinic. He has performed over 20,000 surgical procedures and advised thousands on extending healthspan and lifespan. A prodigy in medicine, Dr. Shah earned his MD at 21 and trained at the Mayo Clinic. He has since launched multiple health ventures, authored a book, and patented medical devices. Committed to ongoing learning, he holds alumni status at Harvard Business School and Singularity University. Dr. Shah is a sought-after speaker on health and longevity. Dr. Adeel Khan, M.D. is a cell and gene therapy specialist with a visionary approach that is changing the way we perceive healthcare worldwide. Khan has cemented his reputation as a regenerative medicine expert and a driven entrepreneur. Dr. Edwin Lee is a board-certified endocrinologist, author, and international speaker specializing in hormonal balance, regenerative, and functional medicine. He founded the Institute for Hormonal Balance in Orlando in 2008 and completed fellowships in Critical Care and Endocrinology at the University of Pittsburgh. Dr. Lee is the lead investigator of an IRB-approved senolytic study exploring compounds like Dasatinib, Quercetin, and Fisetin, and recently published the first human trial using BPC157 for knee pain. He is an assistant professor at the University of Central Florida College of Medicine, co-founder of the Clinical Peptide Society, and founder of SavePeptides.org. His latest book is The Fountain of Youth with Peptides. This episode is brought to you by BIOptimizers. Head to bioptimizers.com/hyman and use code HYMAN10 to save 10%. Full-length episodes can be found here: This Breakthrough Blood Therapy Could Add Years To Your LifeStem Cells & Peptides: The Secret to Reversing Chronic Pain and Aging?How Peptides Enhance Healing and Longevity

In this episode of the Bendy Bodies Podcast, Dr. Linda Bluestein welcomes Dr. Ilene Ruhoy, a board-certified neurologist and environmental toxicologist, for an in-depth discussion on brain fog, cognitive dysfunction, and chronic fatigue in conditions like Ehlers-Danlos Syndrome (EDS), Mast Cell Activation Syndrome (MCAS), and dysautonomia. Dr. Ruhoy shares insights on the immune system's role in neurological symptoms, the impact of mast cell activation, and the role of treatments like peptides, IVIG (intravenous gammaglobulin), plasmapheresis, and immune modulators. They also discuss the hidden effects of histamine on the brain, how sensory sensitivity contributes to fatigue, and the role of regenerative medicine in connective tissue healing. This episode is packed with cutting-edge research and practical solutions for improving cognitive function and energy levels. Takeaways: Brain Fog & Fatigue Are Linked to Immune Dysfunction: Cognitive dysfunction in conditions like EDS, MCAS, and POTS is often tied to inflammatory responses and immune dysregulation rather than just histamine alone. Plasmapheresis & IVIG Can Help Some Patients: For severe cases, plasmapheresis removes inflammatory mediators from the blood, and IVIG helps regulate immune function, leading to cognitive and fatigue improvements. Histamine Plays a Complex Role in Brain Function: While histamine can trigger symptoms in MCAS patients, it also has neuroprotective effects, making antihistamine overuse a potential issue for some. Sensory Sensitivity Increases Cognitive Load: Many people with EDS and related conditions experience hypersensitivity to light, noise, and smells, which can overwhelm the nervous system and worsen fatigue. Regenerative Medicine May Support Connective Tissue Repair: Peptides, stem cell therapy, and targeted immune modulation are promising areas of research to help strengthen connective tissue and reduce systemic inflammation. Connect with YOUR Hypermobility Specialist, Dr. Linda Bluestein, MD at https://www.hypermobilitymd.com/. Thank YOU so much for tuning in. We hope you found this episode informative, inspiring, useful, validating, and enjoyable. Join us on the next episode for YOUR time to level up your knowledge about hypermobility disorders and the people who have them. Join YOUR Bendy Bodies community at https://www.bendybodiespodcast.com/. Learn more about Human Content at http://www.human-content.com Podcast Advertising/Business Inquiries: sales@human-content.com YOUR bendy body is our highest priority! Learn about Dr. Ilene Ruhoy Instagram: @IleneRuhoyMDPhD TikTok: @IleneRuhoyMDPhD Podcast (YT): @Unraveledpod Twitter: @RuhoyMD Bluesky: @ruhoy.bsky.social Keep up to date with the HypermobilityMD: YouTube: youtube.com/@bendybodiespodcast Twitter: twitter.com/BluesteinLinda LinkedIn: linkedin.com/in/hypermobilitymd Facebook: facebook.com/BendyBodiesPodcast Blog: hypermobilitymd.com/blog Part of the Human Content Podcast Network Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode of the Bendy Bodies Podcast, Dr. Linda Bluestein welcomes Dr. Ilene Ruhoy, a board-certified neurologist and environmental toxicologist, for an in-depth discussion on brain fog, cognitive dysfunction, and chronic fatigue in conditions like Ehlers-Danlos Syndrome (EDS), Mast Cell Activation Syndrome (MCAS), and dysautonomia. Dr. Ruhoy shares insights on the immune system's role in neurological symptoms, the impact of mast cell activation, and the role of treatments like peptides, IVIG (intravenous gammaglobulin), plasmapheresis, and immune modulators. They also discuss the hidden effects of histamine on the brain, how sensory sensitivity contributes to fatigue, and the role of regenerative medicine in connective tissue healing. This episode is packed with cutting-edge research and practical solutions for improving cognitive function and energy levels. Takeaways: Brain Fog & Fatigue Are Linked to Immune Dysfunction: Cognitive dysfunction in conditions like EDS, MCAS, and POTS is often tied to inflammatory responses and immune dysregulation rather than just histamine alone. Plasmapheresis & IVIG Can Help Some Patients: For severe cases, plasmapheresis removes inflammatory mediators from the blood, and IVIG helps regulate immune function, leading to cognitive and fatigue improvements. Histamine Plays a Complex Role in Brain Function: While histamine can trigger symptoms in MCAS patients, it also has neuroprotective effects, making antihistamine overuse a potential issue for some. Sensory Sensitivity Increases Cognitive Load: Many people with EDS and related conditions experience hypersensitivity to light, noise, and smells, which can overwhelm the nervous system and worsen fatigue. Regenerative Medicine May Support Connective Tissue Repair: Peptides, stem cell therapy, and targeted immune modulation are promising areas of research to help strengthen connective tissue and reduce systemic inflammation. Connect with YOUR Hypermobility Specialist, Dr. Linda Bluestein, MD at https://www.hypermobilitymd.com/. Thank YOU so much for tuning in. We hope you found this episode informative, inspiring, useful, validating, and enjoyable. Join us on the next episode for YOUR time to level up your knowledge about hypermobility disorders and the people who have them. Join YOUR Bendy Bodies community at https://www.bendybodiespodcast.com/. Learn more about Human Content at http://www.human-content.com Podcast Advertising/Business Inquiries: sales@human-content.com YOUR bendy body is our highest priority! Learn about Dr. Ilene Ruhoy Instagram: @IleneRuhoyMDPhD TikTok: @IleneRuhoyMDPhD Podcast (YT): @Unraveledpod Twitter: @RuhoyMD Bluesky: @ruhoy.bsky.social Keep up to date with the HypermobilityMD: YouTube: youtube.com/@bendybodiespodcast Twitter: twitter.com/BluesteinLinda LinkedIn: linkedin.com/in/hypermobilitymd Facebook: facebook.com/BendyBodiesPodcast Blog: hypermobilitymd.com/blog Part of the Human Content Podcast Network Learn more about your ad choices. Visit megaphone.fm/adchoices

Episode summary and time stamps I. Introduction (0:00-1:31) Host Intro: Introduces Gillian Ehrlich, DNP, ARNP,(Neuroveda Health), highlighting expertise in complex chronic illness, blending #Ayurveda, conventional nursing, #functionalmedicine, and #integrativemedicine. Mentions therapies: #ketamine, #plasmapheresis, #IVtherapies, and conditions treated (e.g., #fibromyalgia, #chronicfatigue, #POTS, #longCOVID). II. Early Influences (1:31-10:38) Childhood: Grew up in polluted Cleveland, OH, noticing tired adults; standard American diet. Jane Esselstyn: Health teacher (daughter of Dr. Caldwell Esselstyn) inspired her with her focus on outdoor education and veganism. Hypermobility: Personal experience with #hypermobility, #EhlersDanlosSyndrome, #POTS, and #mastcellactivation led to finding exercise that worked (rowing). Exploration: Interested in health, but questioned the traditional medical model; explored outdoor leadership, farming, sailing. Ayurveda: Introduced to #Ayurveda by a friend, attended classes with Dr. Vasant Lad, then studied at the Ayurvedic Institute (2000-2001). III. Integrating Ayurveda with Western Medicine (10:38-13:48) Desire for Change: Aimed to bring #Ayurveda insights into conventional medicine; mentored by Keisha Ewers, Dr. Eileen Ruhoy, and Arti Chandra. Challenges: Faced limitations in using #Ayurveda in primary care systems (Swedish, Harborview), due to visit length restrictions. Neuroveda Health: Created own practice to practice freely, offering customized treatments and practical support. IV. Patient Experiences and Philosophy (13:48-18:11) Individuality: Believes people thrive when being themselves, not "average;" Sees beauty in human diversity. Teacher Role: Sees herself as a teacher, helping patients understand needs; emphasizes relaxation for healing (using humor for comfort). Patient Focus: Patients should leave feeling empowered and with the tools to improve their health. V. Neuroveda Health & Integrative Approach (18:11-32:04) Spectrum of Health: Sees complex disease and #longevity as a spectrum of #oxidativeStress, sharing similar approaches. Pancha Karma: Introduced #PanchaKarma (Ayurvedic detoxification), with key components: oilation, treatments, and elimination. Executive Longevity Program (ELP): Modeled on #PanchaKarma, offers 3-21 day programs. Includes #Ayurvedic bodywork, #plasmapheresis, #IVIG, #stemcells, #prolotherapy, ozone, #NAD, mitochondrial #IVs, #ketamine therapy. Designed for significant shifts and then a return to primary providers. Diagnostics/Therapies: Offers autonomic testing, EDS evaluation, skin biopsies, craniocervical instability testing, and other advanced therapies. Frustrations: Noted that patients find #Ayurveda after exhausting all other options. Emphasized the need for neuroplasticity. VI. Ayurvedic Principles in Practice (32:04-37:53) Core Philosophy: #Ayurvedic medicine is core, integrating therapies within this framework. Plasmapheresis/Raktamokshana: Links #plasmapheresis to #Ayurvedic practice of "Raktamokshana" (blood removal) part of #PanchaKarma. Personalization: Treatment is based on disease patterns and #doshas. Case Example: CRPS patient case of using gentle massage because of high #Vata; Digestion was a consideration in her case. Unique Approach: #Neuroveda has a unifying philosophy rooted in #Ayurveda, while other clinics may just combine modalities. VII. Closing Thoughts (37:53-39:35) Keywords: #Ayurveda, #IntegrativeMedicine, #FunctionalMedicine, #ChronicIllness, #PanchaKarma, #Plasmapheresis, #Ketamine, #IVTherapies, #Hypermobility, #EhlersDanlosSyndrome, #POTS, #MastCellActivationSyndrome, #NeurovedaHealth, #Doshas, #Vata, #OxidativeStress, #Raktamokshana, #Longevity, #MECFS, #longCOVID https://www.neurovedahealth.com/ https://www.neurovedahealth.com/executive

If there's one person you'd want to talk to about immunology, the immune system and Covid, holes in our knowledge base about the complex immune system, and where the field is headed, it would be Professor Iwasaki. And add to that the topic of Women in Science. Here's our wide-ranging conversation.A snippet of the video, Full length Ground Truths videos are posted here and you can subscribe. Ground Truths is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.Transcript with many external link and links to the audio, recorded 30 April 2024 Eric Topol (00:06):Hello, it's Eric Topol and I'm really thrilled to have my friend Akiko Iwasaki from Yale, and before I start talking with Akiko, I just want to mention there aren't too many silver linings of the pandemic, but one for me was getting to know Professor Iwasaki. She is my go-to immunologist. I've learned so much from her over the last four years and she's amazing. She just, as you may know, she was just recently named one of the most influential people in the world by TIME100. [and also recognized this week in TIME 100 Health]. And besides that, she's been elected to the National Academy of Medicine, National Academy of Sciences. She's the president of the American Association of Immunologists and she's a Howard Hughes principal investigator. So Akiko, it's wonderful to have you to join into an extended discussion of things that we have of mutual interest.Akiko Iwasaki (01:04):Thank you so much, Eric, for having me. I equally appreciate all of what you do, and I follow your blog and tweets and everything. So thank you Eric.Eric Topol (01:14):Well, you are a phenom. I mean just, that's all I can say because I think it was so appropriate that TIME recognize your contributions, not just over the pandemic, but of course throughout your career, a brilliant career in immunology. I thought we'd start out with our topic of great interest on Long Covid. You've done seminal work here and this is an evolving topic obviously. I wonder what your latest thoughts are on the pathogenesis and where things are headed.Long CovidAkiko Iwasaki (01:55):Yeah, so as I have been saying throughout the pandemic, I think that Long Covid is not one disease. It's a collection of multiple diseases and that are sort of ending up in similar sets of symptoms. Obviously, there are over 200 symptoms and not everyone has the same set of symptoms, but what we are going for is trying to understand the disease drivers, so persistent viral infection is one of them. There are overwhelming evidence for that theory now, all the way from autopsy and biopsy studies to looking at peripheral blood RNA signatures as well as circulating spike protein and nucleocapsid proteins that are detected in people with Long Covid. Now whether that persistent virus or remnants of virus is driving the disease itself is unclear still. And that's why trials like the one that we are engaging with Harlan Krumholz on Paxlovid should tell us what percentage of the people are suffering from that type of driver and whether antivirals like Paxlovid might be able to mitigate those. If I may, I'd like to talk about three other hypotheses.Eric Topol (03:15):Yeah, I'd love for you to do that.Akiko Iwasaki (03:18):Okay, great. So the second hypothesis that we've been working on is autoimmune disease. And so, this is clearly happening in a subset of people, again, it's a heterogeneous disease, but we can actually not only look at reactogenicity of antibodies from people with Long Covid where we can transfer IgG from patients with Long Covid into an animal, a healthy animal, and really measure outcomes of a pathogenesis. So that's a functional evidence that antibodies in some people with Long Covid is really actually causing some of the damages that are occurring in vivo. And the third hypothesis is the reactivation of herpes viruses. So many of us adults have multiple latent herpes virus family members that are just dormant and are not really causing any pathologies. But in people with Long Covid, we're seeing elevated reactivation of viruses like Epstein-Barr virus (EBV) or Varicella-zoster virus (VZV) and that may again be just a signature of Long Covid, but it may also be driving some of the symptoms that people are suffering from.(04:32):So that's again, we see the signature over and over, not just our group, but multiple other groups, Michael Peluso's group, Jim Heath, and many others. So that's also an emerging evidence from multiple groups showing that. And finally, we think that inflammation that occurs during the acute phase can sort of chronically change some tissue tone. For instance, in the brain with Michelle Monje's team, we developed a sort of localized mild Covid model of infection and showed that changes in microglia can be seen seven weeks post infection even though the virus is completely gone. So that means that inflammation that's established as a result of this initial infection can have prolonged sequence and sequela within the person and that may also be driving disease. And Eric, the reason we need to understand these diseases separately is because not only for diagnostic purposes, but for therapeutic purposes because to target a persistent virus is very different approach from targeting autoantibodies, for example.Eric Topol (05:49):Well, that's great. There's a lot to unpack there as you laid out four distinct paths that could result in the clinical syndrome and sequelae. I think you know I had the chance to have a really fun conversation with Michelle about their joint work that you've done, and she reminded me how she made a cold call to you to start as a collaboration, which I thought was fantastic. Look what that yielded. But yeah, this is fascinating because as I think you're getting at is that it may not be the same pathogenesis in any given individual so that all these, and even others might be operative. I guess maybe I first delve into the antibody story as you're well aware, we see after people get Covid a higher rate of autoimmune diseases crop up, which is really interesting because it seems to rev up self-directed immune response. And this I think many people haven't really noted yet, although obviously you're well aware of this, it's across all the different autoimmune diseases, connective tissue disease, not just one in particular. And it's, as you say, the idea that you could take the blood from a person suffering from Long Covid and give it to an experimental animal model and be able to recapitulate some of the abnormalities, it's really pretty striking. So the question I guess is if you were to do plasmapheresis and try to basically expunge these autoantibodies, wouldn't you expect people to have some symptomatic benefit pretty rapidly or is it just that the process is already far from the initiating step?Akiko Iwasaki (07:54):That's a great question. Plasmapheresis may be able to transiently improve the person if they're suffering from these autoantibody mediated diseases. People have reported, for example, IVIG treatment has dramatically improved their symptoms, but not in everybody. So it's really critical to understand who's suffering from this particular driver and appropriately treat those people. And there are many other very effective therapies in autoimmune disease field that can be repurposed for treating these patients as well.Eric Topol (08:34):The only clinical trial that has clicked so far, interestingly, came out of Hong Kong with different types of ways to manipulate the gut microbiome, which again, you know better than me is a major modulator of our immune system response. What are your thoughts about taking advantage of that way to somehow modulate this untoward immune response in people with this condition?Akiko Iwasaki (09:07):Yeah, so that is an exciting sort of development, and I don't mean to discount the importance of microbiome at all. It's just the drivers that are mentioning are something that can be directly linked to disease, but certainly dysbiosis and translocation of metabolites and microbiome itself could trigger Long Covid as well. So it's something that we're definitely keeping our eyes on. And as you say, Eric, the immune system is in intimate contact with the gut microbiome and also the gut is intimate contact with the brain. So there's a lot of connections that we really need to be paying attention to. So yeah, absolutely. This is a very exciting development.Eric Topol (09:57):And it is intriguing of course, the reactivation of viruses. I mean, we've learned in recent years how important EBV is in multiple sclerosis (MS). The question I have for you on that pathway, is this just an epiphenomena or do you actually think that could be a driving force in some people?Akiko Iwasaki (10:19):Yeah, so that's really hard to untangle in people. I mean, David Putrino and my team we're planning a clinical trial using Truvada. Truvada obviously is an HIV drug, but it has reported antiviral activity to Epstein-Barr virus (EBV) and others. So potentially we can try to interrogate that in people, but we're also developing mouse models that can sort of recapitulate EBV like viral reactivation and to see whether there's any sort of causal link between the reactivation and disease process.Eric Topol (10:57):Right now, recently there's been a bunch of anecdotes of people who get the glucagon-like peptide one (GLP-1) drugs which have a potent anti-inflammatory, both systemic and in the brain. I'd love to test these drugs, but of course these companies that make them or have other interests outside of Long Covid, do you think there's potential for a drug like that?Akiko Iwasaki (11:23):Yeah, so those drugs seem to have a lot of miraculous effects on every disease. So obviously it has to be used carefully because many people with Long Covid have issues with liver functions and other existing conditions that may or may not be conducive to taking those types of GLP-1 agonists. But in subset of people, maybe this can be tried, especially due to the anti-inflammatory properties, it may benefit again, a subset of people. I don't expect a single drug to cure everyone. That would be pretty amazing, but unlikely.Eric Topol (12:09):Absolutely. And it's unfortunate we are not further along in this whole story of clinical trials, testing treatments and applauding your efforts with my friend Harlan there to get into the testing which we had hoped RECOVER was going to do with their more than billion dollars or allocation, which didn't get us too far in that. Now before we leave Long Covid, which we could speak about for hours, I mean it's so darn important because so many people are really out there disabled or suffering on a daily basis or periodically they get better and then get worse again. There's been this whole idea that, oh, it's going away and that reinfections don't pose a threat. Maybe you could straighten that story out because I think there seems to be some miscues about the risk of Long Covid even as we go along with the continued circulating virus.Akiko Iwasaki (13:11):Right, so when you look at the epidemiological evidence of Long Covid, clearly in the beginning when we had no vaccines, no antivirals, no real good measure against Covid, the incident of developing Long Covid per infection was higher than a current date where we do have vaccines and Omicron may have changed its property significantly. So if you compare, let's say the Delta period versus Omicron period, there seems to be a reduced risk per infection of Long Covid. However, Omicron is super infectious. It's infected millions of people, and if you look at the total number of people suffering from Long Covid, we're not seeing a huge decline there at all because of the transmissibility of Omicron. So I think it's too early for us to say, okay, the rates are declining, we don't need to worry about it. Not at all, I think we still have to be vigilant.(14:14):We need to be up to date on vaccines and boosters because those seem to reduce the risk for Long Covid and whether Paxlovid can reduce the rate of Long Covid at the acute phase for the high risk individual, it seems to be yes, but for people who are not at high risk may or may not be very effective. So again, we just need to be very cautious. It's difficult obviously, to be completely avoiding virus at this time point, but I think masking and anything you can do, vaccination boosters is going to be helpful. And a reinfection does carry risk for developing Long Covid. So that prior infection is not going to prevent Long Covid altogether, even though the risk may be slightly reduced in the first infection. So when you think about these risks, again we need to be cognizant that reinfection and some people have multiple infections and then eventually get Long Covid, so we're just not safe from Long Covid yet.Nasal Vaccines and Mucosal ImmunityEric Topol (15:24):Right. No, I think that's the problem is that people have not acknowledged that there's an ongoing risk and that we should continue to keep our guard up. I want to applaud you and your colleagues. You recently put out [Yale School of Public Health] this multi-panel about Covid, which we'll post with this podcast that gave a lot of the facts straight and simple diagrams, and I think this is what you need is this is kind of like all your threads on Twitter. . They're always such great educational ways to get across important information. So now let's go onto a second topic of great mutual interest where you've also been a leader and that's in the mucosal nasal vaccine story. I had the privilege of writing with you a nice article in Science Immunology back in 2022 about Operation Nasal Vaccine, and unfortunately we don't have a nasal vaccine. We need a nasal vaccine against Covid. Where do we stand with this now?Akiko Iwasaki (16:31):Yeah, so you're right. I mean nasal vaccines, I don't really know what the barrier is because I think the preclinical models all support the effectiveness against transmission and infection and obviously disease. And there is a White House initiative to support rapid development of next generation vaccine, which includes mucosal vaccine, so perhaps that's sort of pushing some of these vaccine candidates forward. You're probably more familiar than me about those kinds of events that are happening. But yeah, it's unfortunate that we don't have an approved mucosal booster vaccine yet, and our research has shown that as simple as a spray of recombinant spike protein without any adjuvants are able to restimulate immune response and then establish mucosal immunity in the nasal cavity, which goes a long way in preventing infection as well as transmission. So yeah, I mean I'm equally frustrated that things like that don't exist yet.The Neomycin and Neosporin SurpriseEric Topol (17:52):Well, I mean the work that you and many other groups around the world have published on this is so compelling and this is the main thing that we don't have now, which is a way to prevent infection. And I think most of us would be very happy to have a spray that every three or four months and gave us much higher levels of protection than we're ever going to get from shots. And your whole concept of prime and spike, I mean this is something that we could have had years ago if there was a priority, and unfortunately there never has been. Now, the other day you came with a surprise in a paper on Neomycin as an alternate or Neosporin ointment. Can you tell us about that? Because that one wasn't expected. This was to use an antibiotic in a way to reduce Covid and other respiratory virus.Akiko Iwasaki (18:50):Right. So yeah, that's a little known fact. I mean, of course widespread use of antibiotics has caused some significant issues with resistance and so on. However, when you look at the literature of different types of antibiotics, we have reported in 2018 that certain types of antibiotics known as aminoglycoside, which includes Neosporin or neomycin, has this sort of unintended antiviral property by triggering Toll-like receptor 3 in specialized cell types known as conventional dendritic cell type 1. And we published that for a genital herpes model that we were working on at the time. But because it's acting on the host, the Toll-like receptor 3 on the host cell to induce interferon and interferon stimulated genes to prevent the replication of the virus, we knew that it could be pan-viral. It doesn't really matter what the virus is. So we basically leverage that discovery that was made by a postdoc Smita Gopinath when she was in the lab to see if we can use that in the nasal cavity.(20:07):And that's what Tianyang Mao, a former graduate student did, in fact. And yeah, little spray of neomycin in the nose of the mice reduce this infection as well as disease and can even be used to treat shortly after the infection disease progress and using hamster models we also showed that hamsters that are pretreated with neomycin when they were caged with infected hamsters, the transmission rate was much reduced. And we also did with Dr. Charles Dela Cruz, a small clinical trial, randomized though into placebo and Neosporin arms of healthy volunteers. We asked them to put in a pea size amount of Neosporin on a cotton swab into the nose, and they were doing that twice a day for seven days. We measured the RNA from the nose of these people and indeed see that more than half the participants in the Neosporin group had elevated interferon stimulated genes, whereas the control group, which were given Vaseline had no response. So this sort of shows the promise of using something as generic and cheap as Neosporin to trigger antiviral state in the nose. Now it does require a much larger trial making sure that the safety profiles there and effectiveness against viral infection, but it's just a beginning of a story that could develop into something useful.New Frontiers in Immunology and Tx CellsEric Topol (21:51):Yeah, I thought it was fascinating, and it does bring up, which I think has also been underdeveloped, is our approaches for interferon a frontline defense where augmenting that, just getting that exploiting the nasal mucosa, the entry site, whether it be through that means or of course through even more potent a nasal vaccine, it's like a missing, it's a hole in our whole defense of against this virus that's led to millions of people not just dying, but of course also sick and also with Long Covid around the world. So I hope that we'll see some progress, but I thought that was a really fascinating hint of something to come that could be very helpful in the meantime while we're waiting for specific nasal vaccines. Now added to all these things recently, like last week you published a paper in Cell with your husband who's in the same department, I think at Yale. Is that right? Can you tell us about that and this paper about the whole new perspectives in immunology?Akiko Iwasaki (23:05):Yeah, so my husband Ruslan Medzhitov is a very famous immunologist who's in the same department, and we've written four or five review and opinion pieces together over the years. This new one is in Cell and it's really exploring new perspectives in immunology. We were asked by the editors to celebrate the 50th anniversary of the Cell journal with a perspective on the immune system. And the immune response is just a beautiful system that is triggered in response to specific pathogens and can really provide long-term or even sometimes lifelong immunity and resistance against pathogens and it really saves our lives. Much has been learned throughout the last 20, 30 years about the innate and adaptive immune system and how they're linked. In this new perspective, we are trying to raise some issues that the current paradigm cannot explain properly, some of the mysteries that are still remaining in the immune system.(24:22):And we try to come up with new concepts about even the role of the immune system in general. For instance, is the immune system only good for fighting pathogens or can it be repurposed for conducting normal physiology in the host? And we came up with a new subset of T-cells known as, or we call it Tx cells, which basically is an interoceptive type of T-cells that monitor homeostasis in different tissues and are helping with the normal process of biology as opposed to fighting viruses or bacteria or fungi. But these cells, when they are not appropriately regulated, they are also the source of autoimmune diseases because they are by design reactive against auto antigens. And so, this is a whole new framework to think about, a different arm of the immune function, which is really looking inside of our body and not really fighting against pathogens, but we believe these cells exist, and we know that the counterpart of Tx cells, which is the T regulatory cells, are indeed well known for its physiological functions. So we're hoping that this new perspective will trigger a new set of approaches in the field to try to understand this interceptive property of T-cells.Eric Topol (25:59):Yeah, well, I thought it was fascinating, of course, and I wanted to get into that more because I think what we're learning is this immune system not only obviously is for cancer whole. We're only starting to get warmed up with immunotherapy where checkpoint inhibitors were just the beginning and now obviously with vaccines and all these different ways that we can take the CAR-T cells, engineered T-cells, take the immune system to fight cancer and potentially to even use it as a way to prevent cancer. If you have these, whether it's Tx or Tregs or whatever T-cells can do this. But even bigger than that is the idea that it's tied in with the aging process. So as you know, again, much more than I do, our senescent immune cells are not good for us. And the whole idea is that we could build immune resilience if we could somehow figure out these mysteries that you're getting at, whereby we get vulnerable just as we were with Covid. And as we get older, we get vulnerable to not just infections, but everything going wrong, whether it's the walls of our arteries or whether it's the cancer or the immunity that's going on in our brain for Alzheimer's and neurodegenerative diseases. How can we fix the immune system so that we age more healthilyThe Immune System and Healthy Aging Akiko Iwasaki (27:37):Oh yeah. A lot of billionaires are also interested in that question and are pouring money into this question. It's interesting, but when you think about the sort of evolutionary perspective, we humans are only living so long. In the very recent decades, our life expectancy used to be much shorter and all we had to survive was to reproduce and generate the next progeny. But nowadays, because of this amazing wealth and health interventions and food and everything else, we're just living so much longer than even our grandparents. The immune system didn't evolve to deal with such one to begin with. So we were doing fine living up to 30 years of age or whatever. But now that we're living up to a hundred years, the immune system isn't really designed to keep up with this kind of stressors. But I think you're getting at a very important kind of more engineering questions of how do we manipulate the immune system or rejuvenate it so that we can remain healthy into the later decades? And it is well known that the immune system itself ages and that our ability to produce new lymphocytes, for example, decline over time and thymus that is important for T-cell development shrinks over time. And so anatomically it's impossible to help stop that process. However, is there a way of, for example, transferring some factors or engineering the immune cells to remain healthy and even like hematopoiesis itself can be manipulated to perhaps rejuvenate the whole immune system in their recent papers showing that. So this is a new frontier.Eric Topol (29:50):Do you think that some point in the future, we'll ex vivo inject Yamanaka factors into these cell lines and instead of this idea that you know get young plasma to old folks, and I mean since we don't know what's in there and it doesn't specifically have an effect on immune cells, who knows how it's working, but do you foresee that that might be a potential avenue going forward or even an in vivo delivery of this?Akiko Iwasaki (30:22):Yeah, it's not impossible, right? There are really rapidly evolving technologies and gene therapies that are becoming online. So it's not impossible to think about engineering in situ as you're suggesting, but we also have to be certain that we are living longer, but also healthy. So we do have to not only just deal with the aging immune system, but preventing neurodegenerative diseases and so on. And the immune system may have a role to play there as well. So there's a lot of, I mean, I can't think of a non-genetically mediated disease that doesn't involve the immune system.Eric Topol (31:03):Sure. No, I mean, it's just, when I think about this, people keep talking about the digital era of digital biology, but I actually think of it more as digital immunobiology, which is driving this because it's center stage and in more and more over time. And the idea that I'm concerned about is that we could rejuvenate the relevant immune cells or the whole immune response, but then it's such a delicate balance that we could actually wind up with untoward, whether it's autoimmune or overly stimulated immune system. It's not such a simple matter, as I'm sure you would agree. Now, this gets me to a broader thing which you've done, which is a profound contribution in life science and medicine, which is being an advocate for women in science. And I wonder if you could speak to that because you have been such a phenomenal force propelling the importance of women in science and not just doing that passively, but also standing up for women, which is being an activist is how you get things to change. So can you tell us about your thoughts there?An Activist for Women in ScienceAkiko Iwasaki (32:22):Yeah, so I grew up in Japan, and part of the reason I left Japan at the age of 16 was that I felt very stifled because of the societal norm and expectation of what a woman should be. And I felt like I didn't have the opportunity to develop my skills as a scientist remaining in Japan. And maybe things have changed over the years, but at the time when I was growing up, that's how I felt. And so, I was very cognizant of biases in society. And so, in the US and in Canada where I also trained, there's a lot less barrier to success, and we are able to do pretty much anything we want, which is wonderful, and that's why I think I'm here. But at the same time, the inequity still exists, even in pay gaps and things like that that are easy to fix but are still kind of insidious and it's there.(33:32):And Yale School of Medicine has done a great job partly because of the efforts of women who spoke up and who actually started to collect evidence for pay gap. And now there's very little pay gap because there's active sort of involvement of the dean and everyone else to ensure equity in the medical school. But it's just a small segment of the society. We really need to expand this to other schools and making sure that women are getting paid equally as men in the same ranks. And also, I see still some sexual harassment or more just toxic environment for people in general in academia. Some PIs get away with a lot of behavior that's not conducive to a healthy environment, so I have written about that as well and how we can have antidotes for such toxic environments. And it really does require the whole village to act on it. It's not just one person speaking up. And there should be measures placed to make sure that those people who does have this tendency of abusive behavior that they can get training and just being aware of these situations and corrective behavior. So I think there's still a lot of work left in academia, but things have obviously improved dramatically over the last few decades, and we are in a very, very good place, but we just have to keep working to achieve true equity.Why Don't We Have Immunome Check-Ups?Eric Topol (35:25):Well applauding your efforts for that, and I'm still in touch with that. We got a ways to go, and I hope that we'll see steady and even more accelerated and improvement to get to parity, which is what it should be. And I really think you've been a model for doing this. It isn't like you aren't busy with everything else, so to fit that in is wonderful. In closing up, one of the things that I wonder about is our ability to assess back to the immune system for a moment isn't what it should be. That is we do a CBC and we have how many lymphocytes, how many this, why don't we have an immunome, why doesn't everybody serially have an immune system checkup? Because that would tell us if we're starting to go haywire and then maybe hunt for reactivated viruses or what's going on. Do you foresee that we could ever get to a practical immunome as we go forward? Because it seems like it's a big missing link right now.Akiko Iwasaki (36:33):Yeah, I think that's a great idea. I mean, I'll be the first one to sign up for the immunome.Eric Topol (36:40):But I'm depending on you to make it happen.Akiko Iwasaki (36:44):Well, interestingly, Eric, there are lots of amazing technologies that are developed even during the pandemic, which is monitoring everything from antibody reactivity to reactivated viruses to the cytokines to every cell marker you can imagine. So the technologies out there, it's just I think a matter of having the right set of panels that are relatively affordable because some of these things are thousands of dollars per sample to analyze, and then of course clinical validation, something that's CLIA approved, and then we can start to, I guess the insurance company needs to also cover this, right? So we need to demonstrate the benefit to health in the long run to be able to afford this kind of immunome analysis. But I think that very wealthy people can already get this done.Eric Topol (37:43):Yeah, well, we want to make it so it's a health equity story, not of course, only for the crazy ones that are out there that are taking 112 supplements a day and whatnot. But it's intriguing because I think we might be able to get ahead of things if we had such an easy means. And as you said during the pandemic, for example, my friends here in La Jolla at La Jolla Immunology did all kinds of T-cell studies that were really insightful and of course done with you and others around the country and elsewhere to give us insights that you didn't get just from neutralizing antibodies. But it isn't something that you can get done easily. Now, I think this immunome hopefully will get us to another level in the future. One of the most striking things I've seen in our space clinically before wrapping up is to take the CD19 CAR T therapies to deplete the B cells of people with lupus, systemic sclerosis and other conditions, and completely stop their autoimmune condition. And when the B cells come back, they're not fighting themselves. They're not self-directed anymore. Would you have predicted this? This seems really striking and it may be a clue to the kind of mastering approaches to autoimmune diseases in the future.Akiko Iwasaki (39:19):Yeah, absolutely. So for multiple sclerosis, for example, where B cells weren't thought to be a key player by doing anti-CD20 depletion, there's this remarkable clinical effects. So I think we can only find the answer experimentally in people when they do these clinical trials and show this remarkable effects. That's when we say, aha, we don't really understand immunology. You know what I mean? That's when we have to be humble about what we think we understand. We really don't know until we try it. So that's a really good lesson learned. And these may be also applicable to people with autoimmune phenotype in Long Covid, right? We may be able to benefit from similar kinds of depletion therapy. So I think we have a lot to learn still.Eric Topol (40:14):Yeah, that's why, again, going back to the paper you just had in Cell about the mysteries and about some new ideas and challenging the dogma is so important. I still consider the immune system most complex one in the body by far, and I'm depending on you Akiko to unravel it, not to put any weight on your shoulders. Anyway, this has been so much fun. You are such a gem and always learning from you, and I can't thank you enough for all the work. And the fact is that you've got decades ahead of you to keep building on this. You've already done enough for many people, many scientists in your career, and I know you'll keep going. So we're all going to be following you with great interest in learning from you on a frequent basis. And I hope we'll build on some of the things we've talked about like a Long Covid treatment, treatments that are effective nasal vaccines, maybe even some dab of Neosporin, and keep on the momentum we've had with the understanding of the immune system, and finally, someday achieving the true parity of gender and science. And so, thank you for all that you do.Akiko Iwasaki (41:35):Thank you so much, Eric.************************CreditsHeadshot photo credits by Robert Lisak, Yale School of MedicineMy producer for Ground Truths is Jessica Nguyen, Scripps Research and our technical support for audio/video is by SInjun Balabanoff at Scripps Research.I hope you found the spot informative. Please share itThe Ground Truths newsletters and podcasts are all free, open-access, without ads.Voluntary paid subscriptions all go to support Scripps Research. Many thanks for that—they greatly helped fund our summer internship programs for 2023 and 2024.Note: you can select preferences to receive emails about newsletters, podcasts, or all I don't want to bother you with an email for content that you're not interested in.Comments are welcome from all subscribers. Get full access to Ground Truths at erictopol.substack.com/subscribe

If you care at all about your health and longevity, drop whatever you're doing and listen to today's podcast with Mike's good friend Regan Archibald. It's a mind-expanding ride into the latest breakthroughs for dramatic life extension and age reversal that you do NOT want to miss. Imagine doubling your energy levels, increasing your sleep quality by 80%, packing on 5+ pounds of lean muscle mass and losing 30 lbs of stubborn fat in under 6 months…That's just the average results Regan's clients achieve after following his protocols. Today he pulls back the curtain on the cutting-edge treatments and at-home regimens responsible for these astonishing transformations.You'll hear incredible stories of people in their 60s, 70s and beyond reclaiming the physical vitality and mental clarity of their youth. Mike's 91-year-old mother-in-law lost 35 lbs and went from shuffling with a walker to traveling internationally with ease.Regan reveals the new frontiers of longevity science, like the cord plasma treatment that spurred an average 93% boost in wellbeing for his clients. He's cracked the code to rapidly increase deep sleep, eliminate inflammation, and activate full-body stem cell regeneration - all from the comfort of your home.This episode is a tour of the future of personalized medicine. You'll learn why 94 biomarkers provide a crystal ball into your health, how to find your unfair advantage against aging and become the unapologetic owner of your mind and body.If you're ready to go all-in on your personal evolution and radically upgrade your human experience, then hit play NOW.Key Takeaways:(00:00) Latest breakthroughs in longevity and health optimization.(06:32) Promoting a better lifestyle for long, healthy lives.(11:42) Brain inflammation led to improved focus and memory.(15:20) The importance of comprehensive blood work.(19:52) Clients share health transformation..(23:21) Skepticism about government intervention in health choices.(27:46) Protein structures in plasma help regenerate the body.(31:54) Plasmapheresis and cord plasma activate stem cells.(36:47) Safe and simple treatment for aging challenges.(39:08) Educational insights from analyzing blood reports.(44:10) Personalized medical approach, unique success stories shared.(48:21) Regan talks about hosting fun longevity retreats.Additional Resources:Visit CapabilityAmplifier.com/Labs to watch the “Your Blood Doesn't Lie” video with Regan and a copy of his book, “The Peptide Blueprint.”Visit www.AgelessMedicine.co/Invite to get your invitation for your FREE blood lab test.Listen to the Podcast on iTunes at www.MikeKoenigs.com/CATry out Mike's Ai new tool www.DigitalCafe.Ai

Plasmapheresis, the exchange of infected plasma with fresh plasma from blood, is normally used at the far end of the treatment regimen in cases where no other medication is effective.Dr Kiprov's research on the different immunoregulatory and neuroregulatory properties of plasmapheresis and its benefits establishes plasmapheresis as a prophylactic measure against neurodegenerative conditions and infectious diseases.Read more in Research FeaturesRead the original research: acmcasereport.org

In this Nutritional Therapy and Wellness Podcast episode, host Jamie Belz interviews Rachel Ballard, an RN who wasn't willing to accept the prognosis of a slow, painful, premature death. Rachel is a Registered Nurse, farmer, and Food As Medicine teacher who is currently completing her Nutritional Therapy Practitioner (NTP) certification. After battling back from a rare, paralyzing autoimmune disease, she's helping individuals use food as a tool so they can fight back against chronic conditions and defy the odds. A lover of British television dramas, raising medicinal plants, and scratch cooking, Rachel lives on her Kentucky cattle farm with her husband of twenty-three years and two teenage children. In talking with Jamie, Rachel walks us through her declining health, eventual diagnosis of CIPD (Chronic Inflammatory Demyelinating Polyneuropathy), and her long road to recovery. 04:50 – Symptoms and red flags leading up to diagnosis: Hashimoto's, muscles in eye, limp leg, loss of strength, paralysis, felt like she was “on fire” 07:10 – CIPD Diagnosis with Central Nervous Symptom Overlap causing issues with vision, hearing, digestion, bowel and bladder control, and promoting cardiac arrhythmia 9:00 - IVIG (Intravenous Immunoglobulin) Treatment, Plasmapheresis, Stem Cell Transplant, slow decline 10:10 – Five years to live 11:02 – Subcutaneous IVIG Therapy Failed 13:02 – Hitting the point of desperation, looking at natural medicine for the first time, found the wrong natural medicine professionals for her preference and bio-individuality at the time 19:34 – Buying-in on the alternative approach 21:30 – Corruption in science, “follow the money” 22:30 – Working with an NTP, starting with digestion, making slow progress 27:53 – New hope, new career 30:31 – Bioindividuality 31:57 – TALKING ABOUT FOOD! Simple swaps, things to buy 40:17 - Mindset 42:04 – Car analogy 43:15 – Rachel's list of reversed symptoms/conditions 44:21 – Last question As you'll hear, taking the first steps into a more natural approach to wellness can be challenging, frustrating, expensive, and a little “weird.” Rachel shares how she didn't find any luck or answers with the alternative medicine practitioners she initially saw.* Her story is fun, relatable, and inspirational for those suffering from illness, as well as those looking to peek over the fence from the world of conventional medicine. You can find Rachel's food blog at www.feastandfarm.com. Please SUBSCRIBE and visit www.nutritionaltherapy.com/podcast to record a question for the show. *Not all practitioners of each title are created equally. Remember to give multiple practitioners under one umbrella a chance. This is true for both allopathic and alternative care. :)

Dr Paul Malchesky, with a Master's degree in Chemistry and a Doctorate in Engineering, has been working with apheresis since the 1970's. This is a blood filtration or ‘cleaning' therapy we offer at Neuroveda Health as plasmapheresis (also called plasma exchange, PLEX and TPE (total or therapeutic plasma exchange)). There's been a lot of recent excitement regarding treatment of Long-COVID and as a ‘biohack' for longevity, but the truth is that it's been nearly half a century since the FDA approved this therapy for auto-immune and neurodegenerative conditions. The technology has come a long way and Dr Malchesky has been there the whole time. Of note, Ayurveda, the traditional medical system of India, also recognizes the value of detox and blood cleansing, making plasmapheresis a type of ‘rakta moksha'. This is a modern tool with ancient roots, our favorite kind of therapy. Today, we get into the history and mechanics to describe what this therapy is doing and how broad it's use can be. We discuss: ·     3:30 What is apheresis? ·     4:19 What is the history of apheresis? ·     11:56 What is in blood? What are the components of blood? ·     13.20 About anti-coagulation ·     15:53 Ayurvedic use of blood cleansing called ‘rakta moksa' ·     18:06 Dr Malchesky's personal history with apheresis starting with 1972; Reporting up to 40 diseases treated by 1981. ·     24:40 Comparison of dialysis vs plasmapheresis filtration ·     29:00 Late 70's/ early 80's, efforts to identify the specific proteins associated with certain diseases; findings and curiosity about cryoproteins- precipitates triggered by cold. ·     36:57 Treatment to remove high cholesterol to prevent atherosclerosis. ·     40:29 Description of the last 15 years of apheresis: applications & guidelines have really diversified by geography (centripetal in US & German; membrane for Japan), technology and disease state ·     42:58 Safety of this procedure ·     43:52 Difficulties with this procedure are most typically associated with venous access and sometimes blood pressure changes and/or anti-coagulant use ·     44:40 Recognition that the macromolecules produced as ‘toxic' can present in every silo of medicine: oncology, rheumatology, neurology, and therefore, also make sense to use these treatments for longevity & anti-aging ·     49:43 In studying the toxins removed, it's evident that these toxins removed impair cellular function, so removal can allow cells to perform more of their regular functions. ·     51:08 The goal at Neuroveda Health is that plasmapheresis is part of a larger medical and wellness program to renovate the health from the ground up. ·     51:38 Discussion of Lp(a). ·     53:24 Designing clinical trials using historical experience of the questions and initial clinical trial endeavors with rheumatoid arthritis patients BIO: Dr. Paul Malchesky holds a B.S. Degree in Chemistry from St. Francis University, M.S. degrees in Chemistry from Case Western Reserve University and in Chemical Engineering from Cleveland State University and a Doctorate in Engineering from Cleveland State University. He is President of the International Center for Artificial Organs and Transplantation (ICAOT) and consults for the chemical and medical industries. He has published extensively nearly 500 publications, holds 35 patents, and was co-editor of four books on apheresis. He is active in various professional societies and is the former Editor-in-Chief of Artificial Organs and Managing Editor of Therapeutic Apheresis and Dialysis. He is a Past-President of the International Society for Apheresis. He is an Elected Fellow to the American Institute for Medical and Biological Engineering and The Ohio Academy of Science.  Recently he developed the web site icaot.org that discusses the history of the International Center for Artificial Organs & Transplantation and includes Milestones in the field and invites contributions to its Virtual Collection.

In this episode, join Dr. Sanjeev Goel and Carmelia Ray as they dive into the exciting topic of plasmapheresis and its potential role in age reversal. In this video, they discuss a recent groundbreaking study that showcases how plasmapheresis could lead to age reversal, a concept that was inspired by earlier experiments involving the exchange of blood between young and old mice. Dr. Sanjeev Goel explains the process of plasmapheresis, where plasma is removed and replaced with a solution mimicking plasma, resulting in potential anti-aging effects. They touch on studies involving Alzheimer's patients and the positive outcomes observed, including improved cognitive function. Discover more about this innovative procedure and its potential benefits by visiting the Peak Human website at peakhuman.ca. If you're interested in staying youthful and energized, this podcast episode is a must-listen! Like, subscribe, and share if you find this information valuable. Don't forget to explore the Peak Human Rewards program for more exciting content. Join us for enlightening discussions in upcoming episodes!  

NAD, Intravenous laser therapy, Plasmapheresis, Exosome หัตถการความงามที่กำลังฮิตอยู่ในตอนนี้สรุปดีจริงมั้ย? แล้วมีอะไรที่เป็นข้อควรระวังหรือเปล่า? หมอผิงและหมอจั๊ด นพ.ชลธวัช สุวรรณปิยะศิริ จะพาคุณไปฟังความจริง รวบรวมมาให้หมดที่ Podcast Episode นี้ค่ะ ห้ามพลาดเลยนะคะ!!

So... what if we could slow down or even partially reverse aging? The stuff of science fiction?  Well not much longer.Researchers at UC Berkeley have discovered that perhaps a medically-common technique called plasmapheresis (the same process as simple plasma donation) might already be rejuvenating people. While more dedicated research is needed, Braus proposes (and Scot disposes) of this promising solution to aging. Tune in to learn more. Links to research:https://news.berkeley.edu/2020/06/15/diluting-blood-plasma-rejuvenates-tissue-reverses-aging-in-mice/https://www.sciencedirect.com/science/article/pii/S1473050221001282https://www.science.org/content/article/young-blood-renews-old-miceAt least one company, Lyfspn, is beginning human trials of plasmapheresis longevity treatments. https://longevity.technology/news/be-part-of-bringing-plasmapheresis-to-trial/Help us out and ... Subscribe wherever you listen to podcasts Leave a 5-star review Share your favorite solution with your friends and network (this makes a BIG difference) Comments? Feedback? Questions? Solutions? Message us! We will do mini AMA episodes.Email: solutionsfromthemultiverse@gmail.comAdam: braus@eltoncollege.orgScot: @scotmaupin Thanks to Jonah Burns for the SFM music.

“I'm going to NAD for the rest of my life and I'm never gonna age,” Hailey Bieber tells her friend Kendall Jenner in the latest season of The Kardashians. New anti-aging technologies like NAD+ IV therapy and plasmapheresis are making waves in pop culture—but do they work? What does the latest research say? Medcan chief medical officer Dr. Peter Nord checks in with Dr. Eric Verdin of California's Buck Institute for Research on Aging to separate the science from the snake oil—and to share tips on how we can all take steps to help us live longer, and healthier lives. Check out the episode webpage for links and more info.  

Do you have a loved one suffering from dementia? Are you worried about your own cognitive health as you age? If so, this episode of The Hormone Prescription Podcast is for you!   Our guest, Dr. Heather Sandison, the founder of Solcere Health Clinic, and Marama, the first residential care facility for the elderly of its kind, and a leading expert in the field of integrative medicine, shares her insights on how to protect your brain and prevent or reverse dementia.   In this episode you will learn: The role that hormones play in brain health The benefits of lifestyle changes, including diet and exercise, for cognitive health The genetic determinism of Alzheimer's disease and what you can do to mitigate your risk The tests and treatments available to prevent and treat dementia The complex system science approach versus the reduction approach to brain health And much more!   If you are interested in learning more about how to protect your brain and prevent or reverse dementia, this episode is a must-listen!   (00:00): Do you think that dementia is a done deal and that once you get it, you'll always have it. Well, you need to listen up because that's actually a lie.   (00:12): So the big question is how do women over 40, like us, keep weight off, have great energy balance. Our hormones in our moods feel sexy and confident and master midlife. If you're like most of us, you are not getting the answers you need and remain confused and pretty hopeless to ever feel like yourself. Again. As an OB GYN, I had to discover for myself the truth about what creates a rock, solid metabolism, lasting weight loss, and supercharged energy. After 40 in order to lose a hundred pounds and fix my fatigue. Now I'm on a mission. This podcast is designed to share the natural tools you need for impactful results. And to give you clarity on the answers to your midlife metabolism challenges, join me for tangible natural strategies to crush the hormone imbalances you are facing and help you get unstuck from the sidelines of life. My name is Dr. Kyrin Dunston welcome to the hormone prescription podcast.   (01:05): Hi, everybody. Welcome back to another episode of the hormone prescription with Dr. Kyrin. Thank you so much for joining me today. If you believe that dementia is a done deal in that, once you have it, you will always have it. It will progress and get worse. Then you need to listen up because that is just not true anymore. The truth is that you can prevent and reverse cognitive decline and Alzheimer's and other types of dementia. When you take a root cause all systems approach. And my guest today is an expert on this. She is going to break it down for you. She's also hosting a wonderful summit that is coming up on Alzheimer's and cognitive functioning and dementia and how to prevent and reverse it. So I definitely want you to attend that. We'll have the link in the show notes, because this is for everyone.   (02:00): You know, don't hear this title and think, oh, uh, my brain is fine, right? It takes decades to develop cognitive decline and dementia. And so if you have a brain, and you're a human, and you're getting older, which is just about every one of us, then you need to listen up, cuz you need to be doing things, taking steps to protect your precious brain, your mainframe computer. Now. So we'll dive into talking to Heather. She gave a masterclass today about all the things that you need to be doing for your brain. Don't be overwhelmed though, because in her summit she's going to go into with experts like me, way more detail. And of course I'm the hormone expert and hormones. You definitely need a prescription for hormones. If you want to protect your brain, you cannot have optimized brain function without it. So we'll dive into that, but I'll tell you a little bit about Dr.   (02:56): Heather and we'll get started. She's really rather remarkable. Dr. Heather Sandison is the founder of SOCE health clinic and MIMA the first residential care facility for the elderly of its kind at SOCE Dr. Sandison and her team of doctors and health coaches focused primarily on supporting patients, looking to optimize cognitive function, prevent mental decline and reverse dementia by addressing root causes of imbalance in the brain and body. This is something all of you should be doing. She was awarded a grant to study an individualized integrative approach to reversing dementia and is a primary investigator on the it H N C L R clinical trial at Marama. Dr. Sandison has created an immersive residential experience in the lifestyle proven to best support brain health. She understands that changing her diet, adding nutrients, creating community and optimizing a healing environment are all challenging. Even for those with full cognitive capacity at Marama, she's done the work for you, all you or your loved one need to do is show up. She is also the host of the reverse Alzheimer's summit and collective insights podcast, where she works to share what is possible for those suffering with dementia. Welcome Dr. Heather Sandison.   (04:23): Thanks. It's so exciting to be here with you.   (04:25): Yeah, I am so excited about your summit coming up. Many of my listeners know that my mom suffers with advanced Alzheimer's and I really I'm so passionate about helping others to know how to prevent and reverse cognitive decline. Cuz personally, I think it is the most devastating disease someone could be diagnosed with. How did you come to be so passionate about preserving cognitive capacity and preventing and reversing Alzheimer's?   (04:59): Well, as you know, it's an absolutely torturous disease, not only for the person experiencing it, but for all of their loved ones who have to watch this slow painful demise. And the reason I became so passionate was because there's a bit of injustice in this, right? I was told that there was nothing you could do for dementia by very well meaning very well educated instructors when I was in school just 10, 12 years ago, right? Like this is very recent history I was told. There's nothing you could do to suggest otherwise is to give someone false hope and that's just cruel. Right? So don't do that. And then fast forward a few years I saw Dr. Bison speak at a conference and I was really intrigued because his approach, he was saying, you could reverse dementia. You could reverse cognitive decline. And his approach made a lot of common sense.   (05:54): It just wasn't common practice to kind of put all of functional medicine together and apply it to someone with dementia. So what he was describing was BA essentially complex system science approach, the opposite of the reductionistic approach that conventional medicine has been taking for decades, where they try to create one pill or one IV formula that's gonna cure Alzheimer's right. And then everybody's gonna get on it and nobody's gonna have it again. Well, this is really a false premise. It doesn't work because it's based on this idea that beta amyloid plaques or tell proteins these pathological or, or histological really physiological changes. They're almost like scar tissue in the brain that they are the ones that cause dementia or, or Alzheimer's when in fact it's what causes that scar tissue is what causes dementia. And so what I saw after seeing Dr Bison speak was that I was intrigued, right.   (06:55): I, I was skeptical, but I was curious. And so like when I had and did his training, I came back to my office still skeptical, but my first patient Linda came into my office after I was on Dr. Bison's website. Right. I was on the list of people who had been trained by him. And so I had patients showing up asking, uh, because there weren't other people in San Diego who had been trained by him at that point. And so Linda came in with her husband, very enthusiastic, totally committed to doing everything she could. Now for your listeners who aren't familiar with a mocha score, this is the Montreal cognitive assessment. And it's a score out of 30. So 30 is perfect. We really wanna get over 26, especially as we're aging. And when we start to be able to measure cognitive decline. So this can be sometimes you hear this called mild cognitive impairment.   (07:46): And I won't go on the tangent about how I feel about that use of language . But as you get down into the teens, lower teens, this is Alzheimer's disease. This is relatively severe dementia, where you're having trouble taking, having a conversation. Maybe you get lost in familiar places. You aren't nonverbal. Like you can still have a conversation, but often you're repeating yourself. Unable to work is very typical at this stage. Now, by the time you get to a two, a three, a four, this person is, is answering with yes or no statements, right? They're they can't hold complex concepts in their mind. They can't hold questions for very long. And this is where Linda was. Linda was at a two out of 30. So she could answer with yes or no. Her handwriting had been affected. So it was a bit shaky. It was at a very severe slant.   (08:35): It was very, very small letters. Her relationship with her husband of course, was severely affected. They couldn't hold a conversation and he loved her so much. I mean, it was so inspiring to watch how committed he was to her and how much he wanted to work hard to get her back. And I could see in Linda, she had this big, bright smile, and she was in there. She wore these loud, amazing clothes, you know, lots of mismatch and lots of color and hats and accessories. It was just great. And you could see who she had been and these little remnants personality that were peaking through. Well, her and her husband went home and they got out of a moldy bedroom. She got hers removed from her mouth. She got on biodentical hormones. She started all of the supplements. They went fully keto. They started ballroom dancing three to four times a week.   (09:28): And they started walking like vigorous walking exercise every day of the week and low and behold, six, seven weeks later, she came back and her mocha was a seven. Her life had been transformed. So she was now bickering with her husband about something that had happened on the ride to the clinic, which I was just like in disbelief. I could, I thought, you know, I was looking at her mocha scores, her worksheets and going, did we do it wrong? Like, did we miss anything? Like I just, my brain couldn't process that this was possible because I had been told the old refrain that people are still told that, that you couldn't do this. That this was impossible that I started crying because I was like, wait, what? This really works. And especially, I didn't have the confidence that it would work with someone with such severe disease.   (10:18): So when I saw in that moment, when I saw what was possible for Linda, I mean, how could anyone not commit themselves to this for the rest of their lives, right? Like this is possible for Linda. Then what's possible for everyone else who is younger. Who's just noticing those first signs that their brain isn't working the way it used to 10 or five years ago. What's possible for people who know their genetic risk, if they can prevent it from ever even starting. We know that dementia, the changes in the brain, the inflammation, the toxic assaults, the, the infections, the imbalances that cause dementia, the trigger that scar tissue formation, those imbalances start decades before anyone notices changes in their cognitive function, in their memory. And so if we can intervene sooner, we can make Alzheimer's optional. People do not have to go down the torturous path that your mom has.   (11:19): You could be scared. Your children could be spar. The torture of having to watch that of having to put someone in a home because they don't feel like they have the capacity to both raise their own children, work their full-time job, manage their house and care for the, their debilitated loved one with dementia. My life's purpose is changing the narrative around this, which is why I was so grateful that you joined me on the reverse Alzheimer's summit to help me in this crusade around telling people that I'm sorry, respectfully. I disagree with your neurologist who told you here's acept and Meda. It doesn't work very well. Get your affairs in order. There's nothing else that can be done. There's actually an overwhelming amount that can be done to support someone who's noticing their memory fading.   (12:07): Oh my gosh. She said so much in there. And when you told Linda's story and how she and her husband just went and made radical changes in seven weeks had marked improvement. I cried because it's just such demonstrative of what is possible when people really take this seriously and they do all the things and they radically reevaluate and change their lifestyle. What is possible? It's sad to me that it requires us to have such pain in order to do it. We have to go so far that people aren't willing to do it, but I love that they did it. Oh my gosh. You've said so many things. all right. So let's dive into this, but I, I think this idea of complex systems science approach versus reduction approach really is the whole shift in paradigm in medicine that is about antiaging, metabolic, functional medicine.   (13:06): It is the healthcare revolution. It is the next frontier. There's so many areas where we take this reductionist approach. Like it's just a disease, it's just symptom management and you have to deal with it and you have to control it, particularly not only with dementia. I think dementia is where this shows up as just this hopeless attitude of, oh, this is it. Get your affairs in order here, take these medicines. They don't really help. So let's dive a little into all the things that you've got to do, but I wanna start by talking, you mentioned genetic risk and I know people have heard there's Alzheimer's gene. They can't, most people readily access this, or maybe they can maybe, you know, of a place that people can get this, unless their doctor orders it. Can you talk a little bit about the genetics? What is the genetic determinism level with Alzheimer's and what's available? Mm-hmm   (14:04): yeah, there's a lot of agency here, right? Like, so even if you have the worst genetics, there's still a chance that you'll be in the camp that doesn't get dementia. Right. So there it's much more about epigenetics than it is about genetics. Right? So that, that, the way I describe it to patients is it's as if an architect has written the, has drawn the plans for a house and that's your genetic, so that's the plan. And then where you build that house, if it's by the beach, or if it's up in the mountains or it's in the desert, if there's carpet or tile, or, you know, if it's facing east or west, if there's a happy family or a sad family in it, right? Like all of these epigenetic effects determine what that house ends up looking like. And, and if it's a great house to live in or not, and that's essentially your body, right?   (14:50): So there's this genetic plan. And then there's the phenotype or what actually gets expressed, which is the actual house that gets built. Right? And so what we put into that house, what we put into that house that, you know, houses our soul that is so critically important to how that plan gets manifested. And so when we look at genetics, there are a few things and we are now, uh, you do have to get it through a doctor, but we are now offering the Alzheimer's risk test. And this takes not only APO E for genetics. So APO E genetics, let me describe APO E real quick, because this is kind the one that people know the most about and is the most indicative of late onset Alzheimer's. So there are a very rare form of early onset Alzheimer's and this would be your AP P your amyloid precursor protein and your Priscilla one and two.   (15:41): We do not test for that. So for that, we have people go to a geneticist and, and understand their risk there. Now, even if they do have that risk, that elevated risk, we wanna be as proactive as possible, right? This just means you need to work a little harder than your neighbor or your spouse to do all of the things on the bison protocol and prevent this risk for manifesting. There is still a way this genetics are not determination, right? You, you, it's not black and white that you are destined to have, uh Alzheimer's if you have these genes. So, but what we wanna do is we wanna get on top of it faster. So then APO E APO E our ancestors all had APO E four, four, APO E basically predisposes you to create amyloid plaques earlier, quick, more quickly, when you are exposed to something that's causing inflammation in the brain.   (16:34): So amyloid and tell proteins that they're antimicrobial, they're there to protect us. So they've been vilified and conventional medicine as the cause of Alzheimer's, but they're actually there in response to a trigger in the brain. And so, if you are creating these quicker, you do have a higher risk of dementia. And what we see this also APOE also affects fat metabolism, particularly saturated fat metabolism. So if you have a co you have a copy from mom, a copy from dad, and if you have an APOE four from mom and an APOE four from dad, you have a 50% chance of developing dementia. So my job is to make sure you're in the 50% that never gets any sign of cognitive decline. Now, the general population has about a 13% risk of developing dementia. So this is a highly increased risk. Now, if you have an APO E there's two, three, and four, two is pretty rare, but a three, four, it happens.   (17:30): And this means you've got one, a three from mom or dad, and then a four from mom or dad. You have about a one in three risk of getting dementia. So again, I wanna keep you in that 66% that never gets dementia. Then if you have a, a two, three or a three, three or 2, 2, 1 of the other combinations without a four from mom or dad, then you have about a 9% risk of developing dementia. There's a little bit of protection actually from having an APOE two. So we use the Alzheimer's risk test, which takes another 112,000 single nucleotide polymorphisms, and takes them through an algorithm that was developed in the UK, and then gives someone a score. A very it's easy to look at, right? It's not a lot of snips. It's not one of these kind of through the internet, you get your raw data things.   (18:16): This is a, this gives you a score that has a, a lot of very sophisticated data. That's been compiled and then analyzed. And it gives you a score out of one. So one being very high risk, zero being very low risk, and it includes a O E four, but also other genetic snips, single nucleotide polymorphisms. So if I'm talking to someone who is, say the daughter of someone with dementia, or the son of someone with dementia, maybe even the sibling or cousin of someone with dementia, this is a great test to take because there are people with a O E four who actually have relatively low genetic risk. There are people without a O E force positive alleles who have relatively high risk. And so we don't wanna oversimplify. Uh, and this test is the most accurate in determining whether or not someone will develop dementia. It's even more accurate than looking at amyloid in say, imaging or cerebral spinal fluid, or however, they're they find, um, ways to do that. Now, uh, I think they might even have a blood test that's available for research.   (19:22): Okay. I know everybody's listening and, and really, I have never met a person who's not concerned about this. Although most women are most concerned about breast cancer. They're I think this is really where they should focus, because if you do get breast cancer in this day and age, you're most likely not going to diet from it, but an Alzheimer's dementia will certainly pause significant disability and premature death. So people can get this from your clinic. Can they get this from any doctor? Cuz I know there are women listening who are like, okay, I hear you, Dr. Heather, I need this test. Where do I get it?   (19:58): So anyone in the us can get it through our clinic. What we do is we have a doctor who will review it with you and then they can help you find a BR trained provider near you. If you have high risk, we're gonna wanna do that quick. But if you have low risk, you know what a relief. So we have a doctor who can help you get that test. It's it's a pretty new test. It's clear. So it it's not reimbursed by insurance yet. So it's on the cutting edge. It's used most commonly actually in the pharmaceutical industry so that the scientists there can determine who's at higher risk and then target those people for drug discovery and for, and for the, the science that they're doing. Now, we wanna apply this so that we can get people preventing dementia. And so that's why I've really done my best to make it as widely available as possible, even though not many doctors in the us are offering it. So through my clinic, anywhere in the us, you can get this test done. And then we'll, you'll talk to a doctor here at Ary who will talk you through the implications and, and the interpretation of that, and then help get you supported by the bison train provider who can take it from there.   (21:05): Okay. Awesome. And we will have the links and the show notes for all of this. So you can go there and get the links. And Dr. Heather has a great download for you, which will come to before we wrap up. So, okay. So we've got our risk, everybody. I think everyone should get checked now do not wait. And then let's talk about this complex system science approach versus reduction approach. You mentioned my favorite topic, hormone therapy. My mom was without hormones for, you know, over three decades. And that really was the only risk factor she had for dementia. And I am a huge proponent of the benefits of hormone replacement therapy. Not only for cognitive function, I mean, se what is it? 77 or 79% reduction in getting Alzheimer's if a woman is on hormone replacement therapy, I mean, that's just insane. It should be criminal not to give it   (22:05): Well, you, you mentioned the breast cancer risk, right? This is I think what, yeah, a lot of people from pulling the trigger on a hormone replacement and I think what you said was perfect, right? Like, no, of course we don't want anyone to get breast cancer. However, there's been a lot of data that was misconstrued by the media that was misinterpreted. You know, they've gone back to the women's health initiative study and put some caveats on this whole idea that there was an increased risk of breast cancer. That was with oral estrogens. That was when non-bio identical estrogens. So we're not talking apples to apples when we consider bio identical hormone replacement now. And when you think about aging and what's going to be the most torturous, the most debilitating, the most expensive breast cancer is highly treatable. We are so lucky that we live in a time when breast cancer is really highly treatable. Mm-hmm . So even if there is this like a little bit of increased risk, which my understanding of the data.   (23:05): Actually it's reduction, there's a reduction in risk of getting breast cancer. If you're on biodentical hormones. So you have a reduction in risk of breast CA of cancers. It all cause mortality, the, any reason for death, you have a reduction in risk for, and then the two things that affect women as they age, the most that are the most debilitating are gonna be a fall or dementia. These are gonna be the things that end you up in, in skilled nursing for too long, and then result in death and a torturous death where you're separated from your family, because you have to be in, in, in, you know, some kind of high acuity care and then dementia. I mean, this is torturous. Not only because just in and of itself, it's absolutely demoralizing. You lose all of your, of course cognitive capacity over time, but you also, you lose your dignity more than anything.   (23:54): And this can last for a decade or more. No one knows when the torture is going to end it also it's financially bankrupting, right? Not only is it emotionally bankrupting and exhausting for any caregiver, it is financially bankrupting as well. And so if we can prevent falls and we can prevent dementia by getting on hormones, particularly if someone already has say osteoporosis or risk of bone disease or has risk of dementia, either genetically or they're starting to notice changes, particularly as they go through menopause, then the risks are far outweighed by the benefits when we consider hormone replacement therapy, if it's bio identical and the estrogen is used topically.   (24:39): Yeah. So, so well said, thank you for sharing all of that. I agree. And wouldn't you say that the causes, uh, the factors that contribute to the creation of dementia are, are similar same factors to what contribute to bone thinning and osteoporosis.   (24:59): Absolutely. Well, that's one of the amazing things about this co this complex system science approach, right? Is that instead of saying, what's that one thing that causes dementia, what we say is, Hey, how can we get every cell in the body working and functioning better? And when we do that, well, low and behold, the side effects are that your blood pressure normalizes, your hemoglobin A1C goes back to normal. You no longer have diabetes, your osteoporosis starts to improve. Yeah. The, the kind of the four part approach to like my formula for osteoporosis is estrogen replacement with, of course with progesterone and testosterone got nice and balanced and help with muscle building. So biodentical hormone replacement with estrogen being most important there, vitamin D with K minerals and then, uh, weight bearing exercise. And with those four things, I also like to check osteocalcin and beta cross ops and the blood every six months and then a DEXA scan every two years. And with that kind of plan, that basic simple plan. I see the majority of my patients, their bones get stronger on Dexus year, uh, every other year when we check.   (26:07): Yes. Awesome. So I hope everybody's listening and taking care of these things. And I know in the summit that you're hosting, I'm super excited about it. You have experts that are gonna go in way more detail into all of these. So everybody listening needs to click the link in the show notes and sign up for that now, because you know, hopefully you're getting the, the message loud and clear that dementia is preventable and you can do things and you need, need to get on this early and often and take care of it. Or if you're already walking down that lane that you need to get out of it. So definitely wanna check that out, but briefly, what are some of the other factors I know you've touched on them. We've D we've talked about genetics in a little more detail, bioidentical hormones. What are some other factors that need to be addressed?   (27:02): Yeah, well, we're giving away the keto diet guide. So I wanna talk a little bit about the fuel that brain runs on. So the vast majority of us live our days in glycolysis burning sugar for fuel. So ATP is that fuel it's like that gasoline that gets our cells going. It gives them all the energy to make new memories, to make those connections in the brain. We've all had that feeling of being kind of tired and it's a heavy lift to do something mentally. Well, if we are on our burning sugar for fuel that over time as we age, our brains are less sensitive to both sugar and to insulin that allows the sugar into the cells from the blood into the cells to be turned into fuel. So this doesn't work as efficiently. Now this is regardless of if you have diabetes or insulin resistance, anyone as we age, if we have been on a sugar, uh, burning carbohydrates for fuel.   (27:55): And when I say sugar, I also be pasta bread, corn, you know, tortilla chips, all of the carbs, even squash and fruit. When we have been having consuming that every day for our entire lives, we don't get an opportunity to go into ketosis and burn fat for fuel. And so the brain starts to become less sensitive. It no longer efficiently burns sugar. And what we can do, this is the magic of the ketogenic diet is that we can flip the switch. We can turn our energy production from turning sugar into fuel, to turning fat into fuel and just switching the fuel. I mean, this is I, this is just divine design. It makes me I would get chills. When I think about how intelligent the body is and how is able to change out the fuel and burn it really efficiently. And so what people notice is that after getting on a ketogenic diet, they sleep better. They wake up with more energy, they lose weight. If that's the goal, cuz it's, it's very modulating for weight, their blood sugar improves and their memory comes back. They feel sharper cognitively. So I don't know if Kyrin you've ever been asked like, yo, is there a way that you can get more hours in my day? I just feel like there's not enough time   (29:16): For everything,   (29:17): Especially women, right? We're like doing so much constantly juggling and a ketogenic diet in my personal experience is the way to get another for me. I get another hour and a half in my day because instead of dragging myself out of bed at six 30 or seven, I'm up at five and I'm ready to go. This is certainly for me. I personally find it magic. And for so many of my patients, there was actually a, so many of my patients also report this. Now there was a, a trial done. It was a small feasibility trial of just nine participants. It was done in Florida and it was published in January of 2022 where they took nine again, nine participants with some co measurable cognitive decline. And they put them on a ketogenic diet for just six weeks. And they had statistically significant changes in cognitive functions. Six weeks later, if you were struggling with cognitive issues, this is the first spot. This is the first place to go. This does a lot of the heavy lifting. And I would say, this is about if I were to weight all of the interventions, cuz there's a lot, right? This can start to feel overwhelming and complex. But if I were to weight them, I would say the ketogenic diet does about half of the lifting.   (30:28): I love that you really put it into perspective. So it's not about weight. I think people hear keto diet and they think it's only about weight. And a lot of people don't have a weight problem, completely dismiss it, but you really highlight the importance of it and this metabolic flexibility and theology that you get with it. It's like the diet that keeps on giving. But do you think people should do it all the time?   (30:56): Yeah. Such a great point. I'm so glad you said that because no, it's just as bad to always be burning sugar for fuel as it would be to always be burning fat for fuel. So that term metabolic flexibility is really the goal. Our ancestors, our hunter gather ancestors did not have sugar available all the time. They did not have fat available all the time. They had periods of fasting. And so again, our divine design, the way we are, our design is to go back and forth between ketosis burning fat for fuel and glycolysis burning sugar for fuel. And when we, if our body, the chance to do that, the way our hunter gather ancestors did our body works better. It's almost, it's a bit of a stressor. This concept is called the hormetic effect or hormesis where we ask the body to be under a little bit of stress, just like exercise does this. Some calorie restriction or intermittent fasting can do this. And then the ketogenic diet is a fasting mimicking diet where we stress the body a little bit in order to get it to be more resilient. And so as we do that, we, we have, we also get, as you mentioned, auto, we senescent cells are kicked out of the system. We recycle them. We get rid of them. So that the cells that, that replace them are new and more efficient, more optimally functioning.   (32:17): Yes. Awesome. What other factors? So you, you laid it out keto diet as big does 50% of the heavy lifting. I love that. What are some other factors though that people might be alerted that they might need to attend to in   (32:31): Our practice at SOCE? And certainly through the medicine protocol, we wanna be comprehensive about how we do this. So there are two big things that increase my confidence that this approach is going to work one you're early on in the disease process. So you've just started noticing changes. If you even have it all the best is prevention, right, where you've never even noticed changes. So first thing that increases confidence is that we aren't waiting until the disease is severe. The second thing that increases my confidence is how comprehensive you can be about applying the treatment plan. So if you can do all of it, then my confidence goes through the roof. This is a lot like Linda. They did it all and they did it all right out of the gate and they got the benefits. So I get it. Not everybody's able to do that.   (33:15): And even small changes you will get benefit from. But as we stack them on top of each other, you get, you get this kind of virtuous cycle. They all work better when they work together. Okay. So we wanna be systematic about how we approach this and Dr. Bren trains providers this way. And certainly at Ary, we aim to be, uh, systematic and have check boxes, right? Because it can be a lot and feel overwhelming. So the way I think about it is we want to address there's five primary things that cause complex chronic disease. In my model, that it's toxicity, which have three flavors of toxicity microtoxins or biotoxins that come from the indoor air environment, most commonly heavy metals and then chemical toxins. These are things like petrochemicals. If you live near the freeway, this can be parabens, PCBs, SS, pesticides, herbicides, things that are in groundwater that contaminate groundwater, uh, those can come from lots of areas in the environment, but we can measure all three flavors of those toxins and then we can get them out and check that box that hopefully becomes something that you complete.   (34:21): So you get rid of all the mycotoxins get rid of all the metals, change up your environment at home or the personal care products or the cleaning products you use. And then we don't have to worry about that anymore, unless there's a new exposure. So toxins, I start there because that's a nice way to kind of check that box and move on. Now your cells can work better, cuz they're not defending you from toxicity or they're not, they're not trying to, uh, the way that Dr Renison puts it. It's great. Um, he says, imagine your brain is like a country. My brain is St right? You're focused on fighting off invaders like infections or defending from things like toxins. You're not building the infrastructure of new memories of roads and schools, right? In this analogy, you're not creating new memories. You're too busy defending, right?   (35:06): All of your resources are going in that direction. So we wanna get rid of toxins. We wanna have enough nutrients, right? We've gotta have the resources. We've gotta have the building blocks. We need those amino acids. We need those fats. We need those minerals to make all of these biochemical reactions that are necessary for memory building for quick thinking, we need all of those present. If we're depleted, then that's not going to happen efficiently. And then third, we wanna address stressors on the system. So this could be things like sleep deprivation. This could be as stress from, you know, psychosocial stressors, ort S D caregivers are very high risk of developing dementia. They have two and a half times the risk of the population, just because you're a caregiver for someone with dementia, because we often right caregivers wanna put the person they're caring for first.   (35:57): So they're not getting their own exercise. They're not getting enough sleep. It's highly stressful situation. So I really encourage caregivers to listen closely and prevent this disease. Managing stressors. I often will recommend meditation. Meditation is personally something I benefit from having a regular daily practice of mindfulness, meditation, prayer, whatever feels best for you. So managing stressors is another one. Then structure is another one. So we have toxins, nutrients, stressors, structures, structure is gonna be, is your airway open? Are you getting, are you getting oxygen to your brain at night? If you have sleep AP, even if it's mild sleep apnea, you wanna treat this aggressively. I don't care what sleep medicine says. If you are having apnea events at night, that is basically mild brain damage. And I am not okay with that. We have to treat. So whether that means going to your dentist and getting an oral appliance that keeps your airway open.   (36:59): Some people use the mouth tape. I know that sounds a little bit counterintuitive, but you can tape your mouth closed at night so that it forces you to breathe through your nose. Some people will get the nasal strips that, and I like the breathe, right? If you get the generics, they don't work as well. There's of course, the C a P the, the, which has forces pressure into the airway. The other thing that you can do is get the a, a P, and this is the Cadillac. What, from what my patients tell me, this is the Cadillac of C P much more Cadillac.   (37:30): Why is that? Why did they say that?   (37:33): The con, so the AAP is alternating pressure. So the C a P is continuous pressure. And so it doesn't matter what your body's doing. There's no feedback in the system. It just blows, you know, pressure in air I interior system. And when you use the AAP, it adjusts as you're sleeping as, and as you go into different events and then getting the mask that fits right or getting the pillow, whatever, I know that it can take effort going back and forth with sleep medicine, and it can be costly, but this is worth it. Find what works for you. And I've had patients say, oh, I feel like I'm gonna die when I have that mask on. And then it, I push them like, no, no, you've gotta figure this out and do something. Whatever works for you. And then, sure enough, a couple weeks later, they're like, I can't sleep without it.   (38:21): I it's changed my life because now I wake up feeling rested for the first time in a decade or more. So treating sleep apnea, excuse me, very, very important, getting enough, sleep enough rest. And then of course, you know, structurally traumatic brain injuries put people at risk for dementia. So again, the falls, you know, if a woman has a fall regularly and she's hitting her head, this is a really big deal. I'll also say here, the research on women and traumatic brain injuries is lagging behind because a lot of this is done on professional athletes and combat veterans, where there is an epidemic of untreated brain traumatic brain injuries that happens in women who are victims of domestic abuse. And I really hope that in the next couple of years, we see a lot more resources going into this because it's just such a tragedy.   (39:14): Just the way I think about our seniors, right? Who are unnecessarily suffering with dementia is that this it's the squandered resource. They are these people at the height of their wisdom and experience who are, are leaving society. And my job is to help bring them back into the fabric of society so they can be contributing to their families while women who are victims of domestic violence is a very similar thing, but almost just more awful to think about that. We don't know what the combination of asphyxiation. So if someone's being, this gets so graphic and Ugh makes me shutter, but someone who is being both strangled and having, getting traumatic brain injuries at the same time is really having severe detrimental effects on their brain. And we don't know what if progesterone is high. What if she's at a place in her cycle where progesterone is high or low or estrogen is high or low, and these things are happening at the same time and it's happening repeatedly, right?   (40:09): If this is something that ha occurs over and over again, what we see is that these women don't get the help that they need. We don't have the science going into what's going on. And then, because they have essentially a form of dementia, their social worker, who, whoever is there to help them, doesn't realize that maybe they're not working the plan. They're not following the instructions just because they're so overwhelmed and their brain isn't working any as well as it used to because of these injuries. So I really hope that, you know, as speaking to a female audience, there needs to be more compass. There needs to be more support for those who are suffering with dome domestic abuse. And we basically need to understand that they have a form of dementia. Structurally traumatic brain injuries are a very big deal, right? If you get hit over the head with a baseball bat, if you were in a car accident, if you've slipped and fall and hit your head and lose consciousness, even if you don't lose your con lose consciousness, if you have headaches or some sort of recovery time after this is a sign that you have inflammation in your brain, and there are things that we can do right away.   (41:17): Afterwards, we use IV N a D S choline, PSAL serum, high dose fish oils, high dose meth B12, and the sooner we can treat a traumatic brain injury, the better the, the potential that there will be significant recovery. So we talked about toxins, nutrients structure, and now infections. So therefore infections that really stand out here, what is herpes? So herpes. If you ever get outbreaks, whether they're cold sores on your mouth or genital herpes, you wanna treat this relatively aggressively. So I'm a naturopathic doctor, right? I got a big med per medication person, but when it comes to herpes and, and chronic herpes outbreaks, you wanna be treating that aggressively because that can trigger inflammation in the brain, right? We know that herpes kind of stays dormant in the nervous system. Well, whenever it gets retried, that is causing more inflammation in the brain. And this comes out of studies in Taiwan where there's big epidemiological data that showed that people who were treated aggressively with like a, an antiviral, a medication, a prescription antiviral had a lower incidence of dementia than those who had herpes, but were not aggressively treated with, with the pharmaceuticals.   (42:25): So we wanna be getting ahead of that, basically, making sure that those outbreaks are not happening regularly and work with your doctor, of course, on that. So herpes is one PGE GVAs is another. So this is oral health, making sure that there aren't infections in the mouth part of this is just geography, right? You, your mouth is pretty close to your brain. The other thing is that when you get, uh, many people will know that in dentistry, if you've had a knee replacement or a hip replacement, before you go in for a cleaning, you take an antibiotic. Well, the reason is because when you get that cleaning, it introduces those bacteria into your blood and it, that bacteria can then get onto that artificial joint and not be detected and create a, a big problem. It can also create heart disease. It can create cardiac inflammation, can lead to strokes and to cardiac events, and it can trigger the inflammation associated with dementia.   (43:20): So we want to make sure that our oral health, you health starts in the gut and the gut starts in the mouth. So this is really critical that we ha see, I think, a biological dentist we're getting cone being x-rays so that we're catching any insidious small infections in there, early on and effectively treating them. So we have herpes P and GVAs and Lyme disease. So neuro Lyme can be very debilitating. There's a lot of controversy in the field around Lyme, but my opinion is that that there's ly or co-infections present for anyone exhibiting symptoms of dementia, or Alzheimer's that you wanna aggressively treat that with a Lyme literate doctor and get rid of that once. And for all, a neuro Lyme can be very debilitating and also confusing because Lyme is the great imitator. So it looks like a lot of other things and will often go undetected.   (44:13): So anyone with dementia, I do screen them for Lyme and Lyme coinfections. And then the fourth one, many people are familiar with is COVID 19, right? So I know there are a lot of people who would not associate themselves with having dementia at all, but they've suffered with the brain fog following COVID and these viruses. And I think COVID was such a great illustration that it's really these foundations. And I would say it's stressors, structure, nutrients, and, and toxic burden that create whether or not we have balance in those, right? If we have balance the right amounts in the right places at the right times, we have the right amounts of things, then our immune system functions. Well, right. And these are the people who got COVID, but never had a single symptom. And then if we have a lot of imbalance in the system, these are gonna be the people who got COVID in either passed away, right.   (45:03): Unfortunately, or who suffered with long haul COVID right. There's alway already some sort of inflammation, some sort of imbalance. And then that virus comes in and the host that body, that house, that we're in succumbs to the perpetuating cytokine storms or whatever is next in terms of signaling that comes after that virus. And so we want to make sure we're getting that house in order those foundational pieces set. And also looking at that, you know, going back and reassessing, if somebody is struggling with long haul COVID, how can we optimize this? The function of every cell in the body, get those cytokines out. Plasmapheresis is something that's been looked at for dementia, as well as for long haul. COVID so DNRs or the Gupta program. I'm, I'm a fan of the Gupta program for retraining, the limbic system and helping with long haul. COVID there's a lot that we can do. But again, this is, this is part of that landscape of things that lead to dementia over time, that triggering of inflammation of that cytokine storm, that then trigger the production of beta amyloid plaques Andal proteins, which cause are related to, um, Alzheimer's dementia.   (46:18): Woo. Okay. Everybody take a deep breath. I know some people are hyperventilating right now, cuz they were with you on the keto diet and now they're like, oh, I have to do what. Okay. Just breathe. Y'all you're gonna go to the summit. Number one. And you're gonna get way more detail on everything. Dr. Heather has talked to you about today. So you're gonna know exactly what to do after you go to the summit. Exactly. So don't hyperventilate. You don't have to learn it all today and you're gonna go download her keto guide. Number one, we're gonna have the link in the show notes. Um, but I'll, I'll speak it out. It's SOCE right. S O L C E R e.com.   (46:59): Yeah. SOCE solutions for the Cerebra soul or soul shining light. Uh, like sun on the brain. SOCE   (47:06): There we go. Okay. So we'll have that in the show notes, we will have the link to join the summit in the show notes. So you definitely wanna go there. If you're driving, don't click it now, but wherever you're going, when you get there, click it and sign up. You will have experts. There are gonna tell you exactly what to do, including me. We'll talk about biodentical hormones. Of course, my favorite topic, Dr. Heather, thank you so much for this very insightful and inspiring. Look at dementia and Alzheimer's and how we don't have to go down that road. Have, you know, that story that the person's walking down the road and every time they walk down the street, they fall into the same hole. And then even though they try and go, the next time they try to walk around it, they end up falling in it and sometimes they walk past it, but then they end up falling in the hole and sometimes you, the person eventually learns that they can just go down a different street. So it kind of reminds me of that story. You can just go down a different street. People, you don't have to go down the street that most people in, in developed countries are going down towards, uh, dementia or cancer. All the things we're talking about also reduce your risk of cancer. Oh, by the way,   (48:21): All those scary diseases of aging. They are complex chronic diseases and conventional medicine, unfortunately does not shine in that space. Right? If you're in a car accident, if you have a bacterial infection, get to the ER, get to urgent care. But when we talk about diabetes, dementias cancers, this is really where we need to take a step back and take this more comprehensive complex system science approach and get all of those cells working optimally.   (48:50): Yes. Awesome. Well, thank you so much, Dr. Heather, we will see you at the summit. Thank you for joining us.   (48:55): Thank you so much. It's been such a pleasure to be here   (48:58): And thank you all for joining us for another episode of the hormone prescription podcast with Dr. Kirin. I know that you learned something that you can start implementing today in your life to improve your health and go down a different street. I look forward to hearing what that is. Join me on Facebook or Instagram at Kirin Dunston MD, and we will have a conversation about it. And until next week, peace, love and hormones y'all.   (49:25): Thank you so much for listening. I know that incredible vitality occurs for women over 40. When we learn to speak hormone and balance these vital regulators to create the health and the life that we deserve. If you're enjoying this podcast, I'd love it. If you give me a review and subscribe, it really does help this podcast out so much. You can visit the hormone prescription.com, where we have some free gifts for you, and you can sign up to have a hormone evaluation with me on the podcast to gain clarity into your personal situation until next time, remember, take small steps each day to balance your hormones and watch the wonderful changes in your health that begin to unfold for you. Talk to you soon.   Learn how to begin Keto, get food lists, how-tos, tips, and checklists from Dr. Heather Sandison's free Keto Diet Guide. Get it here: https://www.solcere.com/   Reverse Alzheimer's Summit 2022 How This One Diet Is Reversing Dementia... Plus 50+ Other Secrets for Protecting Your Brain From Alzheimer's Disease. We're breaking down the latest advancements in science, medicine, technology, neurology, nutrition, and more to help you reclaim your memories and your life at The Reverse Alzheimer's Summit 2.0   CLICK HERE to register.   Feeling tired? Can't seem to lose weight, no matter how hard you try? It might be time to check your hormones.   Most people don't even know that their hormones could be the culprit behind their problems. But at The Hormone Club, we specialize in hormone testing and treatment. We can help you figure out what's going on with your hormones and get you back on track.   We offer advanced hormone testing and treatment from Board Certified Practitioners, so you can feel confident that you're getting the best possible care. Plus, our convenient online consultation process makes it easy to get started.   Try The Hormone Club for 30 days and see how it can help you feel better than before.   CLICK HERE to sign up: https://www.thehormoneclub.com/home-page-essential  

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. In today's episode, our curiosity rocket ship gonna fly high in space and sky of science and Erudition to explore all about Myasthenia Gravis, an Autoimmune disease/ Disorder. I will start with describing Autoimmune disease, then particularly Myasthenia Gravis, its pathogenesis, how it occurs, where it occurs, where are the signs and symptoms occurring. A little light will be thrown on Historical aspect, then therapy of the disease will be detailed. Drugs like Neostigmine and congeners are discussed, variety of procedures for severe cases like use of Corticosteroids, Theymectomy, Plasmapheresis, etc, are discussed thoroughly. Then little precautions, pros and cons and then Adverse effects etc are too talked upon. I will be conversing in detail about Diagnostic tests for Myasthenia Gravis and lastly Scribble notes about Drug Induced Myasthenia Gravis conditions too will be conveyed... Time to wind up and land the rocket ship which has been soaring high in sky of science and erudition.. For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!! You can access various links via https://linktr.ee/ispharmacologydifficult

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.In today's episode, our curiosity rocket ship gonna fly high in space and sky of science and Erudition to explore all about Myasthenia Gravis, an Autoimmune disease/ Disorder.I will start with describing Autoimmune disease, then particularly Myasthenia Gravis, its pathogenesis, how it occurs, where it occurs, where are the signs and symptoms occurring.A little light will be thrown on Historical aspect, then therapy of the disease will be detailed. Drugs like Neostigmine and congeners are discussed, variety of procedures for severe cases like use of Corticosteroids, Theymectomy, Plasmapheresis, etc, are discussed thoroughly.Then little precautions, pros and cons and then Adverse effects etc are too talked upon.I will be conversing in detail about Diagnostic tests for Myasthenia Gravis and lastly Scribble notes about Drug Induced Myasthenia Gravis conditions too will be conveyed...Time to wind up and land the rocket ship which has been soaring high in sky of science and erudition..For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also.You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links viahttps://linktr.ee/ispharmacologydifficult

Multiple Sclerosis News Today's multimedia associate, Price Wooldridge, discusses how four active progressive MS patients safely underwent a second harvesting and infusion of bone marrow cells in a safety, proof-of-concept trial. He also reads “Pain and Positivity: My Experience With Plasmapheresis,” a column by Beth Ullah.

Plasmapheresis can be a life saving intervention in a number of ICU conditions.  Two potential methods are available – centrifugal plasmapheresis and membrane therapeutic plasma exchange.  But what do we know about the applicability, utilisation and complications of the latter? On this episode, Todd is joined by Mitul Chavda and Alpesh Patel, who recently published 6 years worth of prospective data from their service, run from the Flinders Medical Centre in South Australia.   Baxter Healthcare has provided an educational grant to sponsor this podcast. The content was developed independently of Baxter Healthcare and opinions expressed are those of the presenting healthcare professionals.   See omnystudio.com/listener for privacy information.

Episode 90 of The A&P Professor podcast is a thematic smörgåsbord, full of tasty tidbits to share with students and colleagues. Host Kevin Patton talks about dealing with resistance when we try to take bold steps in teaching. Is note taking better with a paper or an electronic device? The effects of diluting blood plasma on aging (don't try this at home).And the phenomenon of pandemic weight change. 00:00 | Introduction 01:06 | Notetaking: Paper or Digital? 13:14 | Sponsored by AAA 14:53 | Pandemic Twenty? 19:27 | Sponsored by HAPI 20:39 | Diluted Blood: Fountain of Youth? 28:25 | Sponsored by HAPS 29:37 | Taking Bold Steps in Teaching 42:57 | Long-Term Learning Seminar 44:20 | More Bold Steps 50:46 | Staying Connected If you cannot see or activate the audio player click here. Apply for your credential (badge/certificate) for listening to this episode. Please take the anonymous survey: theAPprofessor.org/survey Questions & Feedback: 1-833-LION-DEN (1-833-546-6336) Follow The A&P Professor on Twitter, Facebook, Blogger, Nuzzel, Tumblr, or Instagram! Of all frictional resistances, the one that most retards human movement is ignorance, what Buddha called ‘the greatest evil in the world'. The friction which results from ignorance can be reduced only by the spread of knowledge and the unification of the heterogeneous elements of humanity. No effort could be better spent. (Nikola Tesla)   Notetaking: Paper or Digital? 12 minutes It's the battle of paper notetaking vs. digital notetaking. Who's the winner? Are are we ready to declare a winner? The Pen Is Mightier Than the Keyboard: Advantages of Longhand Over Laptop Note Taking (journal article from Psychological Science) my-ap.us/39qbNCo Don't Ditch the Laptop Just Yet: Replication Finds No Immediate Advantage to Writing Notes by Hand (blog article from American Psychological Association) my-ap.us/39svN7h Don't Ditch the Laptop Just Yet: A Direct Replication of Mueller and Oppenheimer's (2014) Study 1 Plus Mini Meta-Analyses Across Similar Studies (journal article from Psychological Science) my-ap.us/3fpmHff Paper Notebooks vs. Mobile Devices: Brain Activation Differences During Memory Retrieval (journal article from Frontiers in Behavioral Neuroscience) my-ap.us/3u3YjEb Stronger Brain Activity After Writing on Paper Than on Tablet or Smartphone (article at Neuroscience News) my-ap.us/3ftufxE   Sponsored by AAA 1.5 minute A searchable transcript for this episode, as well as the captioned audiogram of this episode, are sponsored by the American Association for Anatomy (AAA) at anatomy.org. Searchable transcript Captioned audiogram  Don't forget—HAPS members get a deep discount on AAA membership!   Pandemic Twenty? 4.5 minutes Originally conceived as the equivalent of the mythical "freshmen 15," the "pandemic 15" may turn out to be the "pandemic twenty" or more. Or less. Listen and find out. How Much Weight Did We Gain During Lockdowns? 2 Pounds a Month, Study Hints (article from New York Times) my-ap.us/3fqgX5a Body Weight Changes During Pandemic-Related Shelter-in-Place in a Longitudinal Cohort Study (journal article from Journal of the American Medical Association) my-ap.us/3dg5L8y   Sponsored by HAPI Online Graduate Program 1 minute The Master of Science in Human Anatomy & Physiology Instruction—the MS-HAPI—is a graduate program for A&P teachers, especially for those who already have a graduate/professional degree. A combination of science courses (enough to qualify you to teach at the college level) and courses in contemporary instructional practice, this program helps you be your best in both on-campus and remote teaching. Kevin Patton is a faculty member in this program. Check it out! nycc.edu/hapi   Diluted Blood: Fountain of Youth? 7.5 minutes New research suggests that diluting our blood plasma could reduce or reverse some effects of aging. Don't try this at home! Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin (journal article) my-ap.us/31lDHeq Diluting blood plasma rejuvenates tissue and reverses aging (summary article of the recent research) my-ap.us/3cjkGiR Rejuvenation of aged progenitor cells by exposure to a young systemic environment. (Journal article on the 2005 research) my-ap.us/3ckyUQu   Sponsored by HAPS 1 minute The Human Anatomy & Physiology Society (HAPS) is a sponsor of this podcast.  You can help appreciate their support by clicking the link below and checking out the many resources and benefits found there. Watch for virtual town hall meetings and upcoming regional meetings! Anatomy & Physiology Society theAPprofessor.org/haps Check out: My Experience in Striving for Equitable Education in A&P Curriculum: Why it Matters to my Students (HAPS blog post) my-ap.us/39q8R8B   Taking Bold Steps in Teaching 13 minutes Ever feel resistance from peers when suggesting a try of  new or different teaching or curriculum strategies? Yeah, me too. No One Is A Prophet In Their Own Land (blog post) my-ap.us/3wdQzkL   Long-Term Learning Seminar 1.5 minute Here's a great refresher of some basic evidence-based strategies that you can use to take a bold step in teaching: Five Powerful Ways You Can Enhance Long-Term Learning in Your A&P Course Topics include: spaced retrieval practice test debriefing pre-testing cumulative testing initial exams Don't forget! You can earn a digital credential in professional development for this online seminar.   More Bold Steps 6.5 minutes The conversation continues with some practical advice. For example, how to bring your critics on board with your bold ideas!   If the hyperlinks here are not active, go to TAPPradio.org to find the episode page. More details at the episode page. Transcript available in the transcript box. Listen to any episode on your Alexa device. Need help accessing resources locked behind a paywall? Check out this advice from Episode 32 to get what you need! https://youtu.be/JU_l76JGwVw?t=440   Take The A&P Professor experience to the next level!  The A&P Professor community   Earn cash by referring other A&P faculty to this podcast:  theAPprofessor.org/refer   Tools & Resources Amazon Text Expander Rev.com Snagit & Camtasia Krisp Free Noise-Cancelling App The A&P Professor Logo Items   Sponsors Transcript and captions for this episode are supported by the American Association for Anatomy | anatomy.org The Human Anatomy & Physiology Society provides marketing support for this podcast | theAPprofessor.org/haps Distribution of this episode is supported by NYCC's online graduate program in Human Anatomy & Physiology Instruction (HAPI) | nycc.edu/hapi Clicking on sponsor links helps let them know you appreciate their support of this podcast! Follow The A&P Professor on  Twitter, Facebook, Blogger, Nuzzel, Tumblr, or Instagram! The A&P Professor® and Lion Den® are registered trademarks of Lion Den Inc. (Kevin Patton) As an Amazon Associate I earn from qualifying purchases. I may be compensated for links to sponsors and certain other links.

Welcome back to the tasty morsels of critical care podcast. Plasmapheresis (or PLEX) is one of the machines we tend not to have responsibility for in the ICU. Unlike CRRT we tend to defer to another specialty to do this. ... Read More »

Susannah Cahalan tells the astonishing true story of her descent into madness, her family’s inspiring faith in her, and the lifesaving diagnosis that nearly didn’t happen. Her New York Times bestselling book “Brain on Fire” was adapted for a movie starring Chloe Grace Moretz as her. It’s an unforgettable exploration of memory and identity, faith and love, and a profoundly compelling tale of survival and perseverance.    She was a healthy young person working at her dream job, The New York Post when she began having grand mal seizures and babbling. Her increasing paranoia and seizures were misdiagnosed by a neurologist as partying too hard combined with stress. Eventually, she’d become catatonic, trapped in her body unable to speak, write, or get thoughts out.    Susannah was diagnosed with a schizoaffective disorder with video of her in the hospital heartbreakingly capturing her real panic as she hallucinates she’s on the news while using the remote to try to call for help. After many misdiagnoses and on the verge of being “locked up” in a psych ward, a miracle doctor, Dr. Najjar comes along and asks her to draw a clock. The lopsided image opened up clues leading to a brain biopsy and spinal tap, she’s diagnosed with autoimmune encephalitis, a medical explanation pretending to be psychiatric.    Her personal experience leads her deeper into the study of other “Great Pretenders,” the same name as her second New York Times best-selling book. She’d blow the lid on a groundbreaking 1973 study called “On Being Sane in Insane Places” that rocked the psychiatric world and still does. Susannah lives in Brooklyn with her husband and twin toddlers.   SHOW NOTE LINKS:   Susannah Cahalan Website   Video of Susannah When Her Brain is On Fire   Rachel's List- Fourteen Incredible Memoirs about Mental Illness and Addiction   Rachel's List- Four MORE Insightful Memoirs and Non-Fiction Books about Mental Illness and Addiction   The Angel and the Assassin by Donna Jackson Nakazawa   Perks of Being a Wallflower by Stephen Chobsky   I’m Telling the Truth, but I’m Lying: Essays by Bassey Ikpi   My Age of Anxiety by Scott Stossel   CONNECT WITH US! *Dear Family, Podcast Page *Write Now Rachel Website *Rachel's Blog @Medium *Rachel’s Twitter *Facebook *Instagram   PLEASE JOIN: *Dear Family Members, the Private Facebook Group     WAYS TO HELP THE PODCAST: *PLEASE Leave a 5-Star Review and Subscribe! Thank you! Your support means the world to me. Wishing you love, happiness, and good mental health always.  

On rounds, I sometimes joke that the two most important organs in the body are the right and left hemisphere. Only one of many, terrible, dad jokes my poor residents and students have to endure. But what happens when one organ fails, or you have to remove it? This week on BrainWaves, we’ll review a unique neurologic condition where such incredible hemispheric dysfunction can only be treated by surgically removing half of the brain. And OMG, a show about pediatrics! ** IF YOU’RE TAKING YOUR NEUROLOGY BOARDS THIS SUMMER, CHECK OUT THE PENN NEUROLOGY BOARD REVIEW COURSE AT https://upenn.cloud-cme.com/default.aspx?P=5&EID=65373. AND FOR A DISCOUNTED RATE ON THE ONLINE OR STREAMING RESOURCES, USE PROMO CODE ‘WAVES2020’. ** Produced by James E. Siegler. Music courtesy of Ars Sonor, Daniel Birch, Jon Watts, and Lish Grooves. The opening theme was composed by Jimothy Dalton. Sound effects by Mike Koenig and Daniel Simion. Unless otherwise mentioned in the podcast, no competing financial interests exist in the content of this episode. BrainWaves' podcasts and online content are intended for medical education only and should not be used for clinical decision making. Be sure to follow us on Twitter @brainwavesaudio for the latest updates to the podcast. REFERENCES Rasmussen T, Olszewski J and Lloydsmith D. Focal seizures due to chronic localized encephalitis. Neurology. 1958;8:435-45. Hart YM, Cortez M, Andermann F, Hwang P, Fish DR, Dulac O, Silver K, Fejerman N, Cross H, Sherwin A and et al. Medical treatment of Rasmussen's syndrome (chronic encephalitis and epilepsy): effect of high-dose steroids or immunoglobulins in 19 patients. Neurology. 1994;44:1030-6. Andrews PI, Dichter MA, Berkovic SF, Newton MR and McNamara JO. Plasmapheresis in Rasmussen's encephalitis. Neurology. 1996;46:242-6. Leach JP, Chadwick DW, Miles JB and Hart IK. Improvement in adult-onset Rasmussen's encephalitis with long-term immunomodulatory therapy. Neurology. 1999;52:738-42. Bien CG, Granata T, Antozzi C, Cross JH, Dulac O, Kurthen M, Lassmann H, Mantegazza R, Villemure JG, Spreafico R and Elger CE. Pathogenesis, diagnosis and treatment of Rasmussen encephalitis: a European consensus statement. Brain. 2005;128:454-71. Varadkar S, Bien CG, Kruse CA, Jensen FE, Bauer J, Pardo CA, Vincent A, Mathern GW and Cross JH. Rasmussen's encephalitis: clinical features, pathobiology, and treatment advances. The Lancet Neurology. 2014;13:195-205. Tan AP, Wong YLJ, Lin BJ, Yong HRC and Mankad K. Clinico-radiological approach to cerebral hemiatrophy. Childs Nerv Syst. 2018;34:2377-2390.

¡Gracias por escuchar! En este episodio se hablará acerca de las alternativas de tratamiento del síndrome de Sjögren primario, tanto glandular como extraglandular.Recuerden que su retroalimentación es bienvenida y les pido amablemente califiquen el podcast en iTunes. Además, Tukua se encuentra disponible en Spotify o a través del gestor de podcasts de su elección.A continuación enlisto algunos de los artículos revisados para este episodio: Vitali, C. et al. Classification criteria for Sjögren’s syndrome: a revised version of the European criteria 21. proposed by the American-European ConsensusGroup. Ann. Rheum. Dis. 61, 554–558 (2002).Shiboski, S. C. et al. American College of 22. Rheumatology classification criteria for Sjögren’ssyndrome: a data-driven, expert consensus approach in the Sjögren’s International Collaborative Clinical 23. Alliance cohort. Arthritis Care Res. (Hoboken) 64, 475–487 (2012).Seror, R. et al. EULAR Sjögren’s syndrome disease activity index: development of a consensus systemic 25. disease activity index for primary Sjögren’s syndrome. Ann. Rheum. Dis. 69, 1103–1109 (2010).Seror, R. et al. Defining disease activity states and clinically meaningful improvement in primary Sjogren’s 26. syndrome with EULAR primary Sjögren’s syndrome disease activity (ESSDAI) and patient-reported indexes (ESSPRI). Ann. Rheum. Dis. 75, 382–389 (2016).Seror, R. et al. EULAR Sjögren’s Syndrome Patient 27. Reported Index (ESSPRI): development of a consensus patient index for primary Sjögren’s syndrome. Ann. Rheum. Dis. 70, 968–972 (2011).Theander, E. et al. Lymphoid organisation in labial salivary gland biopsies is a possible predictor for the 28. development of malignant lymphoma in primary Sjögren’s syndrome. Ann. Rheum. Dis. 70, 29. 1363–1368 (2011).Valim, V. et al. Recommendations for the treatment 33. of Sjögren’s syndrome. Rev. Bras. Reumatol. 55, 446–457 (in Portuguese) (2015).Furness, S., Worthington, H. V., Bryan, G., Birchenough, S. & McMillan, R. Interventions for the management of dry mouth: topical therapies. 34. Cochrane Database Syst. Rev. 12, CD008934 (2011).Steller, M., Chou, L. & Daniels, T. E. Electrical stimulation of salivary flow in patients with Sjögren’s syndrome. J. Dent. Res. 67, 1334–1337 (1988).Vivino, F. B. et al. Pilocarpine tablets for the treatment of dry mouth and dry eye symptoms in patients with Sjögren syndrome: a randomized, placebo-controlled, fixed-dose, multicenter trial. P92-01 Study Group. Arch. Intern. Med. 159, 174–181 (1999).Meijer, J. M. et al. Effectiveness of rituximab treatment in primary Sjögren’s syndrome:a randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 62, 960–968 (2010).Forstot, S. L. & Foulks, G. N. Management of Dry Eye (Oxford Univ. Press, 2012).Toda, I., Shinozaki, N. & Tsubota, K. 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is one of the smartest, most cutting-edge physicians I've ever met, and this is part 2 of my amazing two-part interview with him, recorded from my home in Spokane, WA. You can listen to part 1 at ""  During that first episode we discussed: ...how he's used the nootropic methylene blue to solve a difficult medical case... ...how he's upgrading stem cells to make them far more potent... ...how he's treating depression effectively in as little as 20 minutes with a special brew that includes ketamine, NAD and vitamin IVs... ...how he's reversing musculoskeletal disorders using something called "hydrodissection"... Dr. Cook founded BioReset Medical Corporation and as acting President, operates a Regenerative Medicine and Pain Medicine practice that offers leading-edge non-surgical solutions in orthopedic medicine, sports medicine, regenerative pain medicine, and stem cell medicine. He is a board-certified anesthesiologist with over 20 years of experience in medical practice. Currently, Dr. Cook is President of California Anesthesia and Medical Director of the National Surgery Center, Los Gatos, CA. In addition, he sits on the scientific advisory board of several high profile medical companies including BM DOC, FREMEDICA & VASPER SYSTEMS. Dr. Cook’s early career as an anesthesiologist and medical director of an outpatient surgery center that specializes in sports medicine and orthopedic procedures provided invaluable training in the skills that are needed to become a leader in the emerging fields of Musculoskeletal Ultrasound imaging, nerve hydrodissection, and stem cell medicine. During this Part 2 discussion, you'll discover: -Dr. Cook's Opinion on the use of beta blockers in preparing for performance...9:30 Gave a talk to over 2,000 doctors early in his career Was given a beta blocker by an associate; Heart rate went down to 25 bpm. Never taken another beta blocker since. Sweet spot for everything. Biohacking too high or too low is problematic Has used beta blockers with anesthesia to calm the heart rate. -Plasmapheresis, what Dr. Cook's considers to be one of the "next big things" in the medical industry...11:58 Plasmapheresis A method of removing blood plasma from the body by withdrawing blood, separating it into plasma and cells, and transfusing the cells back into the bloodstream. It is performed especially to remove antibodies in treating autoimmune conditions. It has also been studied as a treatment for neurocognitive and Neuro degenerative problems like Alzheimer’s and Parkinson’s disease. It’s kind of like an oil change in your vehicle. If there is systemic inflammation, often that inflammation is in the plasma of the blood. Different from parabiosis Same procedure as Dr. Mark Urdahl and I discussed on the podcast a few months ago. (Listen to the episode .) Most people who seek plasmapheresis have a serious conditions like Lyme, dementia, Parkinsons, etc. Effect on a healthy person: No negative effect. Nothing wrong with a thorough examination Length of the procedure: 2-3 hours, 1x/week for 6 weeks. -Dr. Cook's thoughts on the use of cannabinoids in his practice...18:50 We have cannabinoid receptors in our brains. Part of our nervous system is called the endocannabinoid system. Expect a surge of use in the next 10 years among health optimizers and chronically ill people. "Entourage effect" Unicorn: a company that is purifying cannabinoids and get all the solvents out Delta 8 THC vs. Delta 9. Rick Simpson Oil: highly potent What are terpines? The terpines are the flavor the smell and much of the effect. The effect of sativa or the effect of the indica is from the terpines in that strain. Can be up to 100 terpines in a strainCan also control flavonoids.... Unicorn can make them bioavailability We are going to be studying these blends Do you give a f*ck? Here's how to follow what's up with the Unicorn brand: -Dr. Cook's approach to dealing with gut issues...31:40 Get a sense of symptoms Test for parasites, the microbiome, stool sample Food goes through the stomach, to small intestine. Small intestine is sterile Goes into large intestine, trillions of bacteria Parasites live in the small intestine SIBO: small intestinal bacterial overgrowth (Listen to my podcast with Dr. Michael Ruscio ) Anti-inflammatory diets Collagen, bone broth, colostrum is efficacious in healing the gut. Everything is fixable. "Bio Reset" -What Dr. Cook likes and uses in his practice with peptides...43:55 Peptide is a smaller version of a protein BPC 157 used in combination with stem cells and treating GI problems TB 500 Thymosin used for chronic infections Peptides becoming common for treatment of chronic illnesses Immune over response and under response - Immune modulation Nootropic peptides: Seamax, Sealance -What is "hyperthermia"?...51:22 Used for treating chronic infections and cancer. Two options under consideration: High tech sauna Venovenus Malarial treatment: German doctor discovered a way to cure malaria using hyperthermia in the 1920's after WWI. -Dr. Cook's approach to treating Lyme disease...59:17 Similar approach as to the gut. Tick-borne illness Effects similar to syphilis Step back, get broadest possible level. Full assessment food allergies pain in joints Neural lyme What modalities have been successful? Ozone Ketamine NAD Peptides Regenerative medicines: exosomes and stem cells (Listen to my podcast with Dr. Harry Adelson ) -How Dr. Cook teaches other doctors in these practices...1:09:00 -And much more! Resources from this episode: Part 1:  -Young Blood Institute podcast -Dr. Michael Ruscio podcast -The Swiss Detox Retreat Ben is leading in summer 2019 -Book - -Podcast with Dr. Harry Adelson Episode Sponsors: - Learn The Most Popular Fasts, How To Do Them, And How They Can Boost Your Health. Get my free guide, Fasting Decoded, get in on all the goodness at - delivers quality nutrition to the world with delicious, easy-to-mix superfood drinks. Hundreds of thousands of women and men use Organifi products to sleep better, get their energy back and achieve their weight loss goals. Use code "Greenfield" at checkout and receive 20% off your entire purchase! - Unlock the power of gratitude. When you introduce conscious, mindful gratitude into your day, positivity will begin to pour into your life – along with all the other scientifically proven physical, mental and spiritual benefits you’re about to discover. Get 20% off your order with coupon code "grateful2019" when you purchase 2 or more journals! - is increasing the prices on their saunas next month. So if you've been thinking of getting one, now's the time. Use coupon code "bengreenfield" and get the original pricing, plus free shipping within the U.S. Do you have questions, thoughts or feedback for Dr. Cook or me? Leave your comments at http://bengreenfieldfitness.com/bioreset2 and one of us will reply!  

Dr. Louis Chicoine Discusses the Effect of Plasmapheresis in Removal of AAV Antibodies for Gene Therapy :: November 2013 Guest: Louis Chicoine, MD, principal investigator in the Center for Gene Therapy, The Research Institute at Nationwide Children’s Hospital; assistant professor of Pediatrics at The Ohio State University College of Medicine. Access an abstract of this month’s featured research article: Plasmapheresis eliminates the negative impact of AAV antibodies on micro-dystrophin gene expression following vascular delivery. Molecular Therapy. 2013 Oct 23. [Epub ahead of print] Major contributors to the work described include the Jesse’s Journey Foundation, the Nationwide Children’s Hospital Foundation, the Muscular Dystrophy Association, a National Institutes of Health grant (U54 NS055958), and a Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Center grant (U54 HD066409).

Dr. Louis Chicoine Discusses the Effect of Plasmapheresis in Removal of AAV Antibodies for Gene Therapy :: November 2013 Guest: Louis Chicoine, MD, principal investigator in the Center for Gene Therapy, The Research Institute at Nationwide Children’s Hospital; assistant professor of Pediatrics at The Ohio State University College of Medicine. Access an abstract of this month’s featured research article: Plasmapheresis eliminates the negative impact of AAV antibodies on micro-dystrophin gene expression following vascular delivery. Molecular Therapy. 2013 Oct 23. [Epub ahead of print] Major contributors to the work described include the Jesse’s Journey Foundation, the Nationwide Children’s Hospital Foundation, the Muscular Dystrophy Association, a National Institutes of Health grant (U54 NS055958), and a Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Center grant (U54 HD066409).

Plasmapheresis in neurolgic disorders: guideline update and 2) Topic of the month: Interviews with Dr. Oliver Sacks. This podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Michelle Mauermann interviews Dr. Irene Cortese about the evidence-based update on plasmapheresis in neurologic disorders. In the next segment, Dr. Jennifer Fugate is reading our e-Pearl of the week about triple-a-sign in Lambert Eaton syndrome. In the next part of the podcast Dr. Ted Burns interviews Dr. Oliver Sacks about posterior cortical atrophy and visual agnosias for our Lesson of the Week. Over the next subsequent two weeks, we will continue to discuss other interesting topics with Dr. Oliver Sacks. The participants had nothing to disclose except Drs. Fugate and Burns.Dr. Burns receives a stipend as Podcast Editor for Neurology®, and performs EMG studies in his neuromuscular practice (30% effort).Dr. Fugate serves on the editorial team for the Neurology® Resident and Fellow Section.