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Meet Jane Grey, Dominatrix and Co-Founder of the Scene and Unscene events. Listen in as Jane opens up about how validation, agency and recognition, drivers behind her acting career, influence her approach to domination; about her plans for the Edinburgh Fringe Festival; and how acting school shunned female sexuality. Eva Oh and Jane discuss the place of acting in a session, if they might be able to submit and how they've tried to escape the ego through the names that they've chosen. We hear about cultural theatrics and how they could shape a Dominatrix's ability and the different ways these two Dominatrices structure their businesses. A very thorough episode of the #teakink Podcast. Watch on YouTube: https://youtube.com/evaoh More on Eva Oh: https://eva-oh.com HIGHLIGHTS: Here are the timestamps for the video episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00:00) - Welcome. What is #teakink (00:00:23) - Jane Grey - Dominatrix, Event Organiser and on a Good Path (00:02:20) - How The Scene and UnScene Events Came About (00:09:15) - The Scene Difference, the Bartenders Bar for Kink (00:14:00) - Authenticity as a Purpose (00:16:10) - How Acting and Drama School Shuns Sexuality (00:20:15) - Validation, Agency, Recognition and the Similarities in Acting and Domination (00:25:10) - South East Asian vs British Theatrics and Social Cohesion (00:27:35) - Growing Star Quality in Professional Domination through Improv Classes (00:29:00) - Moving Around and Growing Adaptability (00:30:35) - Anaesthetising the Ego for Joy (00:32:00) - The Stage vs The Session vs Being a Woman, Is There a Difference? (00:36:30) - How to Go From Personal Kinkster to Professional Dominatrix (00:38:30) - The De-Centring of Our Names - 'Oh' and 'Jane Grey' (00:44:30) - Finding Our Version of Dominance, Visually (00:46:05) - Eva Craving Submission? (00:50:20) - Our Visit to the Edinburgh Fringe Festival and Jane's Show Plans (00:54:50) - Who Do We Tell About Our Job? (00:57:00) - Jane's Subscription Model (01:00:30) - Eva's Cis-het Male Clients vs Her Femme Friends (01:03:50) - The Evolution of Eva's Business Model (01:04:50) - Jane's Plans with the WMH&I Branding Agency, Show Writing and Event Planning (01:09:00) - Eva's Plans on Labours of Love
◎喝酒熬夜必備 OK DRINK⇒ https://dailybiosci.com/WMH 台籃始終讓人猜不透↓↓↓ (01:30) 酒鬼奇航 (04:52) 台籃破局 (12:41) 奧運 (16:52) 自由市場最大贏家與輸家 (31:40) 推歌時間~ Eminem ft. Big Sean & Babytron - Tobey、周杰倫 - 暗號 別忘了小額贊助
On this one Zac and Joe watch the ROAR fuel off road nationals while they talk about the new Traxxas Mud Boss. After RM crossed the finish line Zac got into some battery tech with the consistency of the WMH battery wizard and a ton more! A huge thanks to our sponsors Southern Minnesota RC Raceway and Party Crashers! Check out Southern here for more details on their Dash for Cash https://www.facebook.com/profile.php?id=100063618727893 Check out Party Crashers at this link for their upcoming events https://www.facebook.com/PartyCrashersRCRacing
OK DRINK 醒醒元氣飲
Welcome to our first documentary club! We at WMH love a good documentary, and this week, we watched Netflix's The Greatest Night in Pop. It's a documentary about the making of the hit song “We Are the World,” where legendary musical artists came together to raise money for U.S.A. for Africa. The song was an immediate hit and the night that it took to rally together the biggest stars of the 80s for one song, was nothing short of monumental. We get into all the details of the film in this first iteration of our documentary club, so join us, and watch along.
“Women in leadership,” “women in tech,” “Women's History Month.” This framing positions women as outsiders, but the reality is that women have long been serving in tech and leadership, long before we had the words for it. Tune in with host Jennie Brooks as she sits down with mobility coach and Community Engagement Lead for Booz Allen's Women's Employee Community, Amie Price. Together, they explore what it's been like for Amie to be an early adopter of remote work, the growth that is possible through affinity spaces, and how being “mobility curious” can be leveraged for greater flexibility, adaptability, and retention of talent, whoever they may be. Host: Jennie Brooks, Executive Vice President, Navy Marine Corps TeamWriting, Editing, & Production:- Erin Prah, DEI Program Manager- Enrico E. Manalo, DEI Content StrategistGuest Scheduling:Bridget BunningFor more Unstoppable Together, check out Unstoppable Together Magazine: https://BAH.dcatalog.com/r/DEI-Quarterly
It's Cheryle's birthday, she's 50-fine, and she's ready to talk about aging with us and the WMH family. What's the big deal about getting older, and why are we so obsessed with youth? Plus, we have two guest hosts in the building, a crowd favorite, Erin Allen of WBEZ's The Rundown, and our magical producer Briana Garrett.
New year, who this? 2023? We've never heard of her. We're making room for all that 2024 will bring, and that means new adventures, new discoveries, new hobbies, new peace, love, and positivity. Turn to your neighbor and tell them, “the dreamers are back, new boldness is on the way!” Get ready, WMH family, because we're only going up from here!
It's the holiday season, and we are in high spirits and hoping to pour some too! It's a season to get cozy with loved ones, to share in merriment, reflect, and spread good energy. What makes your holiday season special? Is it the music, the food, the gifts, the people? It's a When Magic Happens holiday, so let's pop some champagne, bump some Nat King Cole, and queue up some holiday fun, WMH-style.
Kleding. Iedereen heeft het nodig en het is - net als voeding - iets waarmee je voor jezelf én voor de wereld kan zorgen. Ik vertel over kwalitatieve en ecologische kleding, het prijskaartje daarvan, fast fashion en online shoppen, hoe leuk het is als de eigenares van je favoriete winkel zegt dat je een taille hebt, wollen kleding, kleding voor thuis, doorgeven en hergebruiken, en waarom een organisatie als WMH belangrijk werk doet. Instagram: @hade_wouters Mijn online trajecten en workshops - kijk hier: https://eu1.course-flow.com/shop/47929/ Op een koffie trakteren als 'vriend van de Tiny Podcast' kan via deze link: https://bunq.me/HadewijchWouters
Let's talk about sex. Remember those cringey sex education courses we had back in the day? The banana and the condom? Well, this isn't that type of conversation. Welcome to When Magic Happens sex education, and we're keeping everything raw and honest. We're talking sex, pleasure, and intimacy with a WMH fave guest, gynecologist, and author of This is How You Vagina, Dr. Nicole. E. Williams.
It's fall and while some might say our summer bodies are in hibernation, WMH is here to remind y'all that a body is a body. In this throwback episode, cozy up with us as we learn to get cozy in our skin. Slim-thick, bean pole, pear, apple – how has your body been categorized? Cheryle, Jennifer and Taylor discuss body image and their relationships to their bodies over time. Then, we hear from Michaela Duerson, a plus-size model, talent agent, photographer and former gymnast, who explains the importance of appreciating our bodies at their many stages and why everyone is wrong.
Why did God strike Uzzah dead for touching the Ark of the Lord? Christy Chermak, Executive Director of Watermark Health, is joined by Jesse Collins and Jack Thurman to talk through an interpretive challenge and also what it looks to celebrate the Lord's goodness! This week Watermark Health is taking over the Join The Journey podcast to celebrate 10 years of WMH! Additional Resources: Got Questions for this passage: https://www.gotquestions.org/Uzzah.html Serve with Watermark Health: https://www.watermark.org/health Watermark Health: https://www.watermarkhealth.org/ Grab a NEW Join The Journey Jr. Journal: https://www.amazon.com/Genesis-Jesus-Vol-Journey-Journal/dp/B0C7TCBFSG/ref=sr_1_4?crid=1RSZG7ERDLZ3F&keywords=join+the+journey+jr&qid=1686838113&sprefix=join+the+journey+%2Caps%2C116&sr=8-4
How do understand the Lord striking down the Philistine army? Christy Chermak, Executive Director of Watermark Health, is joined by Taylor Barnette and Anthony Anderson to talk through an interpretive challenge and how we see the Lord goin before us. This week Watermark Health is taking over the Join The Journey podcast to celebrate 10 years of WMH! Additional Resources: Serve with Watermark Health: https://www.watermark.org/health Watermark Health: https://www.watermarkhealth.org/ Grab a NEW Join The Journey Jr. Journal: https://www.amazon.com/Genesis-Jesus-Vol-Journey-Journal/dp/B0C7TCBFSG/ref=sr_1_4?crid=1RSZG7ERDLZ3F&keywords=join+the+journey+jr&qid=1686838113&sprefix=join+the+journey+%2Caps%2C116&sr=8-4
David's response to Ish-bosheth's murder shows where his heart is. Christy Chermak, Executive Director of Watermark Health, is joined by Rachel Butterfield to talk through David's trust in the Lord and living counter cultural. This week Watermark Health is taking over the Join The Journey podcast to celebrate 10 years of WMH! Additional Resources: Serve with Watermark Health: https://www.watermark.org/health Watermark Health: https://www.watermarkhealth.org/ Grab a NEW Join The Journey Jr. Journal: https://www.amazon.com/Genesis-Jesus-Vol-Journey-Journal/dp/B0C7TCBFSG/ref=sr_1_4?crid=1RSZG7ERDLZ3F&keywords=join+the+journey+jr&qid=1686838113&sprefix=join+the+journey+%2Caps%2C116&sr=8-4
As we transiton from Saul to David's kingship, we get to learn some leadership lessons. Christy Chermak, Executive Director of Watermark Health, is joined by Arnie Kneckt and Samantha Parsons to talk through 2 Samuel 2-3. This week Watermark Health is taking over the Join The Journey podcast to celebrate 10 years of WMH! Additional Resources: Serve with Watermark Health: https://www.watermark.org/health Watermark Health: https://www.watermarkhealth.org/ Grab a NEW Join The Journey Jr. Journal: https://www.amazon.com/Genesis-Jesus-Vol-Journey-Journal/dp/B0C7TCBFSG/ref=sr_1_4?crid=1RSZG7ERDLZ3F&keywords=join+the+journey+jr&qid=1686838113&sprefix=join+the+journey+%2Caps%2C116&sr=8-4
This week Watermark Health is taking over the Join The Journey podcast to celebrate 10 years of WMH! Christy Chermak, Executive Director of Watermark Health, is joined by Bethany Moss to talk about David lamenting the death of Saul and how to process grief. Additional Resources: Serve with Watermark Health: https://www.watermark.org/health Watermark Health: https://www.watermarkhealth.org/ Grief Recovery Ministry: https://www.watermark.org/ministries/griefshare Grab a NEW Join The Journey Jr. Journal: https://www.amazon.com/Genesis-Jesus-Vol-Journey-Journal/dp/B0C7TCBFSG/ref=sr_1_4?crid=1RSZG7ERDLZ3F&keywords=join+the+journey+jr&qid=1686838113&sprefix=join+the+journey+%2Caps%2C116&sr=8-4
Listen to this enthralling conversation between Black People Love Paramore Host Sequoia B Holmes and WMH host Taylor Coward. Put your paws up, because we're talking all about Lady Gaga.
In this episode, Niki, Natalia, and Neil discuss the history of summer break in the United States. Support Past Present on Patreon: https://www.patreon.com/pastpresentpodcast Here are some links and references mentioned during this week's show: · The idea that a long summer vacation originated in “the agrarian calendar” is a persistent myth. Niki referred to our Episode 40, in which we discussed the history of summer camps Natalia referred to historian Kenneth Gold's book School's In: The History of Summer Education in American Public Schools and historian Jonathan Zimmerman's Los Angeles Times opinion piece, “How We Got Interminable Summer Breaks From School – And What We Can Do About It.” In our regular closing feature, What's Making History: · Natalia discussed Max Meyer's Free Press article, “Welcome to the MAGA Hamptons.” · Neil and Niki, for the first time in our history, chose the same WMH! They discussed Jason Aldean's country music song and video, “Try That in a Small Town.” Neil recommended Chris Willman's Variety article, “Jason Aldean Already Had the Most Contemptible Country Song of the Decade. The Video is Worse.”
I found Brand Boss, Bill Harper on TikTok of all places where he has built an impressive library of short form content around branding and marketing. Harper runs an agency out of North Carolina called WMH and it's worth checking out. Bill and I riff on a variety of topics and talk about our experiences and opinions on how to build a brand and how to be successful. There's another side story and lesson learned from my trip to Raleigh North Carolina...There's this saying, Be kind, because everyone is fighting a battle you know nothing about. You never know what someone is going through, right? I was reminded how important this is on a recent trip to Raleigh North Carolina. I was in the airport waiting for my flight back to LA as you do and I saw a man, sitting a little ways away in another terminal and waiting like me, look my way and give me the hello nod. You know what mean, right? He got up and walked over to me — and I'm thinking “okay, do I know this guy?” But he didn't look familiar. Then he asked, are you Bryan Elliott? With all the enthusiasm my introverted self could muster, I muttered yes, and he proceeded to tell me that he's a big fan of the podcast and how much it means to him. I was really flattered but also stunned — like a dear in the headlights — because I don't get approached very much like this. But it was nice. To be honest, the week prior leading up to this trip I was really struggling with feeling like I'm not doing enough and falling short of some of my goals. But that all disappeared with this man's simple act of kindness. And since then it's reminded me about being a bit more grateful about staying focused on things I can control and not on things I cannot. If he's listening right now I'd like to apologize for being so awkward and thank him for making my day a lot brighter. You were headed from Raleigh Durham to Arizona and the Grand Canyon with your family so I hope you had a great trip. I'd like to keep meeting more of you. Can we keep this up? If you see me out and about please say hello. One thing you may not know about being a creator — and I'm sure this applies to everything — Whether you're a creator of music, film, podcast or make a product or service that people use everyday. It's hard to know exactly who's paying attention -- or the impact. But when we do meet, it's an incredible feeling to know that what you're doing matters a little to someone else. Special thanks to our sponsor WeWork!Your working week deserves its little luxuries. Beautiful spaces to spark ideas in person. Designed carefully for collaboration. And peaceful nooks for focus mode.Wifi that... well, works Add unlimited coffee on tap or how about free flowing Kombucha? Tailored networking events and a ready-made community, a true home away from home.Tap in down the road or touch down in locations around the world From Manhattan to Manchester London to LA... Bring the whole team this way And we mean the whole team... (in a whisper like a secret) WeWork is dog friendly Don't just work from anywhere WeWork - Now, you can unlock productive, flexible workspace at over 180 locations near you with WeWork All Access Basic. - Get 30% off your first 5 months by using code BRYANAA30. - To redeem this offer, visit we.co/behindthebrand
Ben Grey is a musician. Ben Grey is the vocalist and guitar player for Dear Boy. I first heard of Dear Boy through the grapevine of LA bands but then I had to tap in Austyn Hayman the other guitar player for Dear Boy for the WMH podcast. Austyn was different, but I didn't think that the rabbit hole of the Dear Boy universe would get bigger but it did. I met Ben Grey in Los Angeles at a show that Austyn played guitar for, then Ben's show at the legendary Hotel Cafe with Austyn. Next thing you know it, I extended my trip and saw Dear Boy open for The Psychedelic Furs. Dear Boy has been around but released their debut album, Forever Sometimes. If I get Lucy on, will it be Dear Girl? Please welcome Ben Grey to Wear Many Hats. instagram.com/benjamingrey instagram.com/dearboyofficial instagram.com/wearmanyhatswmh instagram.com/rashadrastam rashadrastam.com wearmanyhats.com dahsar.com
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.03.526961v1?rss=1 Authors: Tsuchida, A., Boutinaud, P., Verrecchia, V., Tzourio, C., Debette, S., Joliot, M. Abstract: White matter hyperintensities (WMH) are well-established markers of cerebral small vessel disease (cSVD), and are associated with an increased risk of stroke, dementia, and mortality. Although their prevalence increases with age, small and punctate WMHs have been reported with surprisingly high frequency even in young, neurologically asymptomatic adults. However, most automated methods to segment WMH published to date are not optimized for the detection of small and sparse WMH. Here we present the SHIVA-WMH tool, a deep-learning (DL)-based automatic WMH segmentation tool that has been trained with manual segmentations of WMH in a wide range of WMH severity. We show that it is able to detect WMH with high efficiency in subjects with only small punctate WMH as well as in subjects with large WMHs (i.e. with confluency) in evaluation dataset from three distinct databases: MRi-Share consisting of young university students, MICCAI 2017 WMH challenge dataset consisting of older patients from memory clinics, and UK Biobank with community-dwelling middle-aged and older adults. Across these three cohorts with the wide-rangind WMH load, our tool achieved the voxel-level and individual lesion cluster-level Dice scores of 0.66 and 0.71, respectively, which were higher than three reference tools tested: the lesion prediction algorithm implemented in the lesion segmentation toolbox (LST-LPA: Schmidt, 2017), PGS tool, a DL-based algorithm and the current winner of the MICCAI 2017 WMH challenge (Park et al, 2021), and HyperMapper tool (HPM: Mojiri Forooshani et al., 2022), another DL-based method with high reported performance in subjects with mild WMH burden. Our tool is publicly and openly available to the research community to facilitate investigations of WMH across a wide range of severity in other cohorts, and to contribute to our understanding of the emergence and progression of WMH. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
A new research paper was published in Aging (listed as "Aging (Albany NY)" by MEDLINE/PubMed and "Aging-US" by Web of Science) Volume 14, Issue 23, entitled, “White matter hyperintensity load is associated with premature brain aging.” Brain age is an MRI-derived estimate of brain tissue loss that has a similar pattern to aging-related atrophy. White matter hyperintensities (WMHs) are neuroimaging markers of small vessel disease and may represent subtle signs of brain compromise. In this new study, researchers Natalie Busby, Sarah Newman-Norlund, Sara Sayers, Roger Newman-Norlund, Sarah Wilson, Samaneh Nemati, Chris Rorden, Janina Wilmskoetter, Nicholas Riccardi, Rebecca Roth, Julius Fridriksson, and Leonardo Bonilha from University of South Carolina, Medical University of South Carolina and Emory University tested the hypothesis that WMHs are independently associated with premature brain age in an original aging cohort. “We hypothesized that a higher WMH load is linearly associated with premature brain aging controlling for chronological age.” Brain age was calculated using machine-learning on whole-brain tissue estimates from T1-weighted images using the BrainAgeR analysis pipeline in 166 healthy adult participants. WMHs were manually delineated on FLAIR images. WMH load was defined as the cumulative volume of WMHs. A positive difference between estimated brain age and chronological age (BrainGAP) was used as a measure of premature brain aging. Then, partial Pearson correlations between BrainGAP and volume of WMHs were calculated (accounting for chronological age). Brain and chronological age were strongly correlated (r(163)=0.932, p
Hassan Ayub is a Brand Manager who he says does a lot of other things. That includes being a stylist for shoots, account management, event coordination, overall client experience, troubleshooting, and product placement. This is all going down at Yony. A brand that I discovered through a friend and guest of the show, comedian Nick Thune. I met Hassan at the Yony store in LA cruising down La Brea. Me and friend and guest of the show, Harry Gassel took the day off and were bopping to stores checking out what LA had to offer. Me and Hassan immediately hit it off where he was talking to me about plans on how he wanted to start a brand and podcast. Well guess what Hassan, it starts here. Right on WMH. Please welcome Hassan Ayub to Wear Many Hats. instagram.com/hassanghq instagram.com/wearmanyhatswmh instagram.com/rashadrastam rashadrastam.com wearmanyhats.com dahsar.com
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.14.516491v1?rss=1 Authors: Newman, B. T., Danoff, J. S., Lynch, M. E., Giamberardino, S., Gregory, S. G., Connelly, J. J., Druzgal, T. J., Morris, J. P. Abstract: Epigenetic clocks provide powerful tools for estimating health and lifespan but their ability to predict brain degeneration and neuronal damage during the aging process is unknown. In this study, we use GrimAge, an epigenetic clock correlated to several blood plasma proteins, to longitudinally investigate brain cellular microstructure in axonal white matter from a cohort of healthy aging individuals. Given the blood plasma correlations used to develop GrimAge, a specific focus was made on white matter hyperintensities, a visible neurological manifestation of small vessel disease, and the axonal pathways throughout each individual's brain affected by their unique white matter hyperintensity location and volume. 98 subjects over 55 years of age were scanned at baseline with 41 returning for a follow-up scan 2 years later. Using diffusion MRI lesionometry, we reconstructed subject-specific networks of affected axonal tracts and examined the diffusion cellular microstructure composition of these areas, both at baseline and longitudinally, for evidence of cellular degeneration. A chronological age adjusted version of GrimAge was significantly correlated with baseline WMH volume and markers of neuronal decline, indicated by increased extracellular free water, increased intracellular signal, and decreased axonal signal within WMH. By isolating subject-specific axonal regions 'lesioned' by crossing through a WMH, age-adjusted GrimAge was also able to predict longitudinal development of similar patterns of neuronal decline throughout the brain. This study is the first to establish a relationship between accelerated epigenetic GrimAge and brain cellular microstructure in humans. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.27.509283v1?rss=1 Authors: Fongang, B., Satizabal, C. L., Kautz, T. F., Ngouongo, Y. W., SherraeMuhammad, J. A., Vasquez, E., Mathews, J., Goss, M., Saklad, A. R., Himali, J., Beiser, A., Cavazos, J. E., Mahaney, M. C., Maestre, G., DeCarli, C., Shipp, E. L., Vasan, R. S., Seshadri, S. Abstract: A bidirectional communication exists between the brain and the gut, in which the gut microbiota influences cognitive function and vice-versa. Gut dysbiosis has been linked to several diseases, including Alzheimer's disease and related dementias (ADRD). However, the relationship between gut dysbiosis and markers of cerebral small vessel disease (cSVD), a major contributor to ADRD, is unknown. In this cross-sectional study, we examined the connection between the gut microbiome, cognitive, and neuroimaging markers of cSVD in the Framingham Heart Study (FHS). Markers of cSVD included white matter hyperintensities (WMH), peak width of skeletonized mean diffusivity (PSMD), and executive function (EF), estimated as the difference between the trail-making tests B and A. We included 972 FHS participants with MRI scans, neurocognitive measures, and stool samples and quantified the gut microbiota composition using 16S rRNA sequencing. We used multivariable association and differential abundance analyses adjusting for age, sex, BMI, and education level to estimate the association between gut microbiota and WMH, PSMD, and EF measures. Our results suggest an increased abundance of Pseudobutyrivibrio and Ruminococcus genera was associated with lower WMH and PSMD (p-values less than 0.001), as well as better executive function (p-values less than 0.01). In addition, in both differential and multivariable analyses, we found that the gram-negative bacterium Barnesiella intestinihominis was strongly associated with markers indicating a higher cSVD burden. Finally, functional analyses using PICRUSt implicated various KEGG pathways, including microbial quorum sensing, AMP/GMP-activated protein kinase, phenylpyruvate, and {beta}-hydroxybutyrate production previously associated with cognitive performance and dementia. Our study provides important insights into the association between the gut microbiome and cSVD, but further studies are needed to replicate the findings. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer
Our Ep. 26 guest operates under the pen name Stephanie Greenoak. Working for one of the largest tech companies in the world, she's added mindfulness and holistic health counseling to her resume after enduring loss and tough diagnoses within her family. She helps us understand how to show up mindfully when everything sucks. She's also a mom of seven-year-old twins and a caregiver. What's your “Minimum Viable Priority?” Learn with us! Find Stephanie:Resources for WMH community – Mindfulness and Self Acceptance Guide, Time Inventory, DIY Personal Retreat GuideWebsiteFacebookInstagram--Newsletter (more joy in motherhood!):InstagramFacebookYouTubeTwitterLinkedIn
In this final episode of Tried and True, Paul, Dan, Andy and Erica discuss how to search for aspiring leaders to take on the roles in your communities and how to coordinate your schedule with other WMH communities around you. The hosts reflect on their time doing Tried and True and share their thoughts for what will happen next in the Delaware Warmachine Community. :45 - Intro 4:00 - Episode outline 4:40 - Finding leaders in your own community 13:40 - Coordinating with other communities 22:50 - Visiting other communities and being an ambassador 27:40 - What are the plans moving forward? 34:05 - End of Tried and True Google Calendar for NJ, MD, DE, PA - https://calendar.google.com/calendar/embed?src=3ajutk46gl20elrrtu3v3vfoc8%40group.calendar.google.com&ctz=America%2FNew_York
In this episode, meet Paul and Dan as they talk about their history playing Warmachine and what happen to their local metas over the years. Knowing the history, how were they going to use this to provide direction moving forward? :50 - Introductions 6:20 - Goals of Tried and True 6:48 - The history of WMH in Delaware 9:00 - History of WMH in South Philly 12:00 Self Fulfilling Prophesy 12:12 What happened during the Pandemic.
This episode will introduce you to mindfulness. I'll provide clarity on what mindfulness is and where the concept comes from, review the mental health benefits, and give you practical advice and suggestions for getting started. To learn more about me and my reproductive psychiatry clinic helping patients across California, please visit - AnnaGlezerMD.comArticles referenced:BMC Pregnancy 2019: https://pubmed.ncbi.nlm.nih.gov/31601170/Arch of WMH: https://pubmed.ncbi.nlm.nih.gov/30982086/Meta-analysis: https://pubmed.ncbi.nlm.nih.gov/27182732/Midwifery 2018: https://pubmed.ncbi.nlm.nih.gov/30099285/
***Join THC+ for full uninterrupted 2 hour episodes, a dedicated Plus RRS feed, lifetime forum access, merch discounts, & other bonuses like free downloads of THC music: thehighersidechats.com/plus-membershipSee detailed sign up options down below. About Today's Guest: James Franklin Lee Jr. (Jim Lee) helps people understand complex ideas by creating maps, timelines, articles, and lectures. He talks about Pollution, Privacy and Propaganda every chance he gets because they interest him, affect us, and he cares about our Planet. ClimateViewer News is his blog and the central location for all of my research.He has also compiled the largest volume of geoengineering and weather modification history into one massive timeline, complete with lists of companies, patents, sponsors, and laws: Weather Modification History. WMH is an international effort lead by Jim and Domenic Marrama, combining both investigative journalists' superpowers to create an unparalleled online repository of factual references in chronological format. Check out ClimateViewer.org for live Earth monitoring and educational maps. THC Links: Website: TheHighersideChats.com Merch Store: thehighersideclothing.com/shop Leave a voicemail for the Joint Session Bonus Shows: thehighersidechats.com/voicemail Leave us an iTunes review: https://podcasts.apple.com/us/podcast/the-higherside-chats/id419458838 THC Communities: Telegram: https://t.me/joinchat/RIzmxk8_m_qCW7JZ Subreddit: reddit.com/r/highersidechats Discord: discord.com/invite/rdGpKtW THC Plus Sign-Up Options: Subscribe via our website for a full-featured experience: thehighersidechats.com/plus-membership Subscribe via Patreon, including the full Plus archive, a dedicated RSS feed, & payment through Paypal:: patreon.com/thehighersidechats?fan_landing=true To get a year of THC+ by cash, check, or money order please mail the payment in the amount of $96 to: Greg Carlwood PO Box: 153291 San Diego, CA 92195 Cryptocurrency If you'd like to pay the $96 for a year of THC+ via popular Cryptocurrencies, transfer funds and then send an email to support@thehighersidechats.comwith transaction info and your desired username/password. Please give up to 48 hours to complete. Bitcoin: 1AdauF2Mb7rzkkoXUExq142xfwKC6pS7N1 Ethereum: 0xd6E9232b3FceBe165F39ACfA4843F49e7D3c31d5 Litecoin: LQy7GvD5Euc1efnsfQaAX2RJHgBeoDZJ95 Ripple: rnWLvhCmBWpeFv9HMbZEjsRqpasN8928w3
This week Dr. Cruse reports that even though cases are decreasing across the country, they are not yet decreasing here. He is concerned about new surges in less vaccinated pockets of well vaccinated states and is concerned that we may not have peaked yet. He also reviews the limited information on Merck's pill to treat COVID and reminds it that it is not available yet and is not nearly as effective as vaccines. He also reviews information about COVID vaccine recommendations in pregnant women and that their vaccine team will be at the Midwifery Mingle at the Cooperage on Thursday Oct 7. He gives information about how to sign up for vaccines and boosters at WMH.org or (570)253-8197.
We pre-recorded today's conversation as part of our monthly Community Health Partnership with Valley Health to talk about nursing and "The Year of the Nurse." The World Health Organization and American Nurses Association deemed 2020 Year of the Nurse, then extended it through 2021 in recognition of a uniquely challenging year. Joining me for the conversation: Anne Whiteside, Chief Nursing Officer at Winchester Medical Center; Terri Mayes, Chief Nursing Officer at Warren Memorial Hospital; and, Sharon Rigney, Associate Chief Nursing Officer at Winchester Medical Center. We discussed the broad path nursing provides to those seeking a career in healthcare. The women also told us how things have changed during their career both in healthcare, technology and culture. We talked about the changes they've seen/helped promote in nursing practice and empowerment at Valley Health. We also learned about Winchester Medical Center and Warren Memorial Hospital's designations that attest to the positive nursing practice environment: WMC has been a Magnet hospital since 2008; and WMH is 1 of 9 Pathway to Excellence hospitals in VA. Last month, assorted employees and grateful patients contributed to this brief Valley Health nurse appreciation video: https://www.youtube.com/watch?v=T_DBj6C_LP8
En este episodio, nos acompaña un invitado que ya podemos decir es parte integral de nuestro podcast. Ben se nos une para explicarnos el maravilloso mundo de Vassal, para que en tu cuarentena puedas seguir jugando Warmachine! Hablamos del uso básico de la plataforma, de los pros y los contras y además Ben nos cuenta su experiencia jugando un torneo por Vassal. Pero sobre todas las cosas invitamos a todos nuestros escuchas a unirse a nuestro Servidor de DISCORD… en reiteradas oportunidades… muchas veces…. UNANSE AL DISCORD DE CUARTO DE GUERRA! LINK: https://discord.gg/fyJHAQB Les dejamos todos los links para que puedan empezar su aventura en Vassal: NSTRUCCIONES DE DESCARGA DE VASSAL Programa principal: http://www.vassalengine.org/download.php Modulo de WMH: http://www.vassalengine.org/wiki/Module:Warmachine Module:Warmachine Si te sale un error de que necesitas Java, lo descargas de aqui https://www.oracle.com/java/technologies/javase-jre8-downloads.html solo te pide crear una cuenta
Today's COVID update discusses vaccine distribution, Wayne Memorial Health System's website link to sign up for getting vaccine on our website www.WMH.org, and vaccine safety, including new vaccine recommendations in pregnant women.
近期疫情又爆發了，不只是在NBA，台灣也是，大家記得戴口罩，可以來點WMH，陪你度過艱難的時刻↓↓↓ (00:00) San Diego有什麼好玩的？ (03:00) Yo Yo~ (03:52) NBA球員各種隔離缺賽，到底該不該暫停所有比賽？ (09:18) 公牛醒了~ Lavine今年當大哥carry小弟們 (11:15) 看不到D Rose的巔峰 (╥_╥) (13:08) Back to Lavine!要帶公牛殺進季後賽 ᕦ(ò_óˇ)ᕤ (14:19) 公牛教練Billy Donovan aka Eric's Boy / Billy=Bryant (16:00) 兩位國文造紙不好，麻煩大家幫我們想成語！Please Help Us~ (17:17) 突然的MIP 最佳進步獎，到底獎落誰家? (19:54) Blake Griffin 幹籃王變上籃王，所有數據生涯新低，該如何繼續生存下去(-_-) (24:56) Jokic 前10場平均數據大三元 (25:16) Doc Rivers華佗轉世，一個人醫好76人，Embiid中鋒混合體? (28:31) Giannis想要achieve greatness，延續Mamba Mentality，然後體罰女友?( ͡ಠ ʖ̯ ͡ಠ) (31:04) Doc Rivers 帶人帶心帶76人殺出東區! (32:25) 籃網只要現在不要未來，史上最晃3巨頭要怎麼樣才能稱霸全聯盟？ (41:25) Shaq跟Harden槓上，Harden到底有沒有 Give his all to Houston？ (43:35) 預測東西區各前四名，運彩買起來~ (53:50) 推歌時間，來享受一下音樂~ AC/DC - Thunderstruck 、Elvis Presley - Jailhouse Rock 最後記得跟我們互動留言一波和五星撞爆★★★★★
Today's episode examines the life of an eccentric, possibly mentally ill woman and the incredible house she built. We‘ll talk about possible hauntings, impossible architecture and the delusion of a heart broken woman. We are discussing Sarah Winchester and what some less than creative people have dubbed The Winchester Mystery House! Her birth name was Sarah Lockwood Pardee. She was the fifth of seven children born to Leonard Pardee and Sarah Burns. There are no existing records or any other form of factual information to establish Sarah’s date of birth—even the year remains unknown. The scarce information that survives from the historical record indicates her birth must have occurred somewhere between 1835 and 1845. At the time of Sarah’s birth, the Pardee’s were a respectable, upper middle class New Haven family. Her father Leonard was a joiner by trade whose shrewd sense of business found him moving up the ladder of polite society as a successful carriage manufacturer. Later, during the Civil War, he made a fortune supplying ambulances to the Union Army. Young Sarah’s most distinguishing characteristic was that she was everything but ordinary. She was a child prodigy… a fire starter. Ok, no… By all accounts, she was also considered to be quite beautiful. By the age of twelve, Sarah was already fluent in the Latin, French, Spanish, and Italian languages. Furthermore, her knowledge of the classics (most notably Homer… no, not Simpson, and Shakespeare) along with a remarkable talent as a musician was well noticed. It is no wonder that New Haven Society would eventually dub her “The Belle of New Haven.” In addition to Sarah’s brilliance and respectable place in society, there were several factors about New Haven that presented a unique influence on her upbringing. To begin, there was Yale University (originally known as Yale College). From its inception, Yale (and New Haven) was a hub of progressive, Freemasonic-Rosicrucian thinking and activity. By the way, we’ll most definitely be taking a train ride on the Freemasons. As a result, Sarah was raised and educated in an environment ripe with Freemasonic and Rosicrucian philosophy. Several of Sarah’s uncles and cousins were Freemasons. But more importantly, at an early age, she was admitted to Yale’s only female scholastic institution known as the “Young Ladies Collegiate Institute.” Two of the school’s most influential administrators and professors, Judson A. Root and his brother N.W. Taylor Root were both Rose Croix Freemasons. In addition to the liberal arts, the Roots set forth a strict curriculum consisting of the sciences and mathematics. Sounds super fucking boring. Furthermore, two of Sarah’s schoolmates Susan and Rebecca Bacon were the daughters of New Haven’s highly respected Reverend Dr. Leonard Woolsey Bacon (no relation to Francis Bacon, who was an English philosopher and statesman who served as Attorney General and as Lord Chancellor of England. His works are credited with developing the scientific method and remained influential through the scientific revolution, just in case you nerds were wondering.). While Sarah and the Bacon girls were attending the school, Dr. Bacon’s sister Delia, also a New Haven resident, attracted considerable fame and attention for writing her famous treatise that Sir Francis Bacon (with the aid of a circle of the finest literary minds of the Elizabethan-Jacobean Age) was the actual author, editor, and publisher of the original works of Shakespeare. Ah ha! See! Her work was sponsored by the author Nathaniel Hawthorne and was later supported by the likes of Ralph Waldo Emerson and Mark Twain! Good ol Samuel Clemens. In addition to her writing, Delia Bacon gave numerous public lectures to the citizens of New Haven; thus, New Haven, Connecticut was the actual birthplace of the “Bacon is Shakespeare” doctrine. We’re here to learn ya, folks! Given her direct exposure to the Baconian Doctrine, along with her passion for the Shakespearean works, it was inevitable that Sarah was drawn like an irresistible force to a more than passing interest in the new theorem. Moreover, the Baconian-Masonic preoccupation with secret encryption techniques using numbered cipher systems most certainly influenced young Sarah’s world view. This unique backdrop to Sarah’s early development played a crucial role which, in essence, defined what would become her life’s work. So much smarts! As we’ll see, the Belle of New Haven became a staunch Baconian for the rest of her life. She just LOOOVED HER BACON! BLTs, Canadian bacon, pancetta… she loved it all! A completely strict diet of fucking bacon! Except turkey bacon. Fuck that fake shit. No, but seriously, She also acquired a vast and uncanny knowledge of Masonic-Rosicrucian ritual and symbolism… SSSYMBOLISM. Additionally, she gravitated to Theosophy. Theosophy is a religion established in the United States during the late nineteenth century. It was founded primarily by the Russian immigrant Helena Blavatsky and draws its teachings predominantly from Blavatsky's writings.Author and historian Ralph Rambo (who actually knew Sarah and is a direct descendant of American bad ass and war hero John J Rambo) wrote “it is believed that Mrs. Winchester was a Theosophist.” Rambo didn’t elaborate on the matter, making him and his statement one of the more boring we’ve heard, but since he was close to Sarah he was certainly in a position to know some things about her. It should be noted that most Rosicrucians are theosophists. Sarah adhered both to Bacon’s Kabbalistic theosophy, which is the eternal belief in the Mortal Kombat franchise no matter how bad their movies are… ok, that was stupid. Anyway, she was also super into the theosophical perspective held by Rudolph Steiner (1861- 1925). Steiner viewed the universe as a vast, living organism in which all things are likened to individually evolving units or cells that comprise a greater universal, synergistic body that is “ever building.” As we shall further see, the “ever building” theme was at the core of Sarah’s methodology. William Wirt Winchester was born in Baltimore, MD on July 22, 1837. He was the only son of Oliver Fisher Winchester and Jane Ellen Hope. In keeping with a popular trend of the day, he was named after William Wirt, the highly popular and longest serving Attorney General of the United States . Soon after William’s arrival, the Winchesters moved to New Haven where the enterprising Oliver, along with his partner John Davies, founded a successful clothing manufacturing company. Gradually, the Winchester patriarch amassed a considerable fortune. Later, Oliver channeled his efforts into a firearms manufacturing venture that eventually (1866) evolved into the famous Winchester Repeating Arms Company. Fuckin’ Winchester! Woo!! According to historical documents, the Winchesters and the Pardees were well acquainted, particularly through the auspices of New Haven’s First Baptist Church. Additionally, Sarah Pardee and William’s sister Annie were classmates at the Young Ladies Collegiate Institute. Not far away, William attended New Haven’s Collegiate and Commercial Institute—another arm of Yale College. Here, William’s teachers included N.W. Taylor Root (one of Sarah’s instructors) and Henry E. Pardee who was another of Sarah’s cousins. Thus, Young Sarah and William found themselves studying virtually the same curriculum under very similar circumstances. Moreover, like the Pardees, the Winchester family was not lacking in members who were Freemasons. Sarah and William were married on September 30, 1862. Their only child, Annie Pardee Winchester came into the world on July 12, 1866. Unfortunately, due to an infantile decease known as Marasmus (a severe form of malnutrition due to the body’s inability to metabolize proteins), Annie died 40 days later. In 1880, Ol Oliver Fisher Winchester died, leaving the succession of the Winchester Repeating Arms Company to his only son. One year later, William died of fucking Tuberculosis at the age of 43. Dammit, TB! The double loss of Annie and William was a staggering blow to Sarah. However, the loss did leave the widow Winchester with an inheritance of 20 million dollars (510 million today) plus nearly 50% of the Winchester Arms stock—which, in turn earned her approximately $1,000 dollars per day (25,000 today) in royalties for the rest of her life—the result of which made her one of the wealthiest women in the world. Get it, girl! According to Ralph Rambo, john j rambo’s great great uncle, Sarah went on a three year world tour with her new band “Rifles and Posies”, who sold 3 million records worldwide and had a huge hit with their single “fuck tuberculosis” before settling in California in 1884. “The New Haven Register,” dated 1886, lists Sarah as having been “removed to Europe.” No other information has survived to tell us exactly where Mrs. Winchester went during those years or what her activities consisted of. But we can project some well educated theories. Although Freemasonry has traditionally barred women from its membership, there are numerous documented cases in which some head-strong women have gained admittance into liberal, Masonic Lodges as far back as the 18th Century. A movement in France called Co-Freemasonry, which allows for male and female membership was already underway when Sarah arrived in that country. Given her social status, a predilection towards Freemasonic tenets, and a mastery of the European languages, Sarah could easily have been admitted into any of the permissive French Masonic lodges. Another possible scenario involving Mrs. Winchester’s activities while abroad could well have included visits to esoteric, architectural landmarks such as the French Cathedral of Chartres. Sarah’s Masonic-Rosicrucian interest in labyrinths would have drawn her to Chartres with its 11 circuit labyrinth, a puzzle-like feature that stresses the discipline of the initiatic tradition of the ancient mystery schools. Likewise, she would also have found inspiration in the Freemasonic symbolism and the mysterious structure (including a staircase that leads nowhere) of Rosslyn Chapel in Scotland . In 1884, Sarah took up residence in the San Francisco Bay area—eventually moving inland to the Santa Clara Valley (now San Jose) to buy an eight room farmhouse from one Dr. Robert Caldwell. Her apparent motive for the move was to live in close proximity to her numerous Pardee relatives, most of whom had come to California during the 1849 Gold Rush, and were scattered from Sacramento to the Bay area. One of these Pardee relatives, Enoch H. Pardee, had become a highly respected physician and politician while living in Oakland. Later his son George C. Pardee followed in his father’s footsteps rising to the office of Governor of California (1903- 1907. It is interesting that Wikipedia makes particular note of Enoch Pardee having been “a prominent occultist.” Most likely the occult reference has to do with the fact that both Enoch and his son George were members of the highly secretive and mysterious ( California based) Bohemian Club which was an offshoot of Yale’s Skull and Bones Society. Moreover, Enoch and George were Knights Templar Freemasons. Also interesting, is the fact that President Theodore Roosevelt (another member of the Bohemian Club) came to California in 1903 to ask Governor Pardee to run as his Vice Presidential candidate in the 1904 national election. The offer was turned down. During the same trip, Roosevelt attempted to visit Sarah Pardee Winchester. Again, Roosevelt’s offer was turned down. THE STORY BEHIND THE HOUSE The story goes that after the death of her child and her husband she moved to California and bought the 8 room farmhouse and began building. It is said once construction started it was a continuous process. Workers in the area would work in shifts 24 hours a day, 7 days a week. We're going to explore the stories about her mental state, the construction of the house, and the reports of ghosts and spooky stuff. The story supposedly starts like this: There was no plan – no official blueprints were drawn up, no architectural vision was created, and yet a once-unfinished house took shape on a sprawling lot in the heart of San Jose, California. Inside, staircases ascended through several levels before ending abruptly, doorways opened to blank walls, and corners rounded to dead ends. The house was the brainchild of Sarah Winchester, heir by marriage to the Winchester firearms fortune, and since the project began in 1884 rumors have swirled about the construction, the inhabitants, and the seemingly endless maze that sits at 525 South Winchester Blvd.Today, the house is known as the Winchester Mystery House, but at the time of its construction, it was simply Sarah Winchester’s House. Newly in possession of a massive fortune and struggling with the loss of her husband and daughter, she sought the advice of a medium. She hoped, perhaps, to get advice from the beyond as to how to spend her fortune or what to do with her life. Though the exact specifics remain between Sarah Winchester and her medium, the story goes that the medium was able to channel dearly departed William, who advised Sarah to leave her home in New Haven, Connecticut, and head west to California. As far as what to do with her money, William answered that too; she was to use the fortune to build a home for the spirits of those who had fallen victim to Winchester rifles, lest she be haunted by them for the rest of her life. So there's that… Spirits from beyond told her to build! After this is when she ended up in San Jose and purchased the farm house. Winchester hired carpenters to work around the clock, expanding the small house into a seven-story mansion. The construction of the House was an “ever building” enterprise in which rotating shifts of workers labored 24 hours per day, 7 days a week, 365 days a year. the House gradually mushroomed outward and upward,By the turn of the century, Sarah Winchester had her ghost house: an oddly laid out mansion, with seven stories, 161 rooms, 47 fireplaces, 10,000 panes of glass, two basements, three elevators, and a mysterious fun-house-like interior. It was built at a price tag of the $5 million dollars in 1923 or $71 million today. Due to the lack of a plan and the presence of an architect, the house was constructed haphazardly; rooms were added onto exterior walls resulting in windows overlooking other rooms. Multiple staircases would be added, all with different sized risers, giving each staircase a distorted look. Gold and silver chandeliers hung from the ceilings above hand-inlaid parquet flooring. Dozens of artful stained-glass windows created by Tiffany & Co. dotted the walls, including some designed by Louis Comfort Tiffany himself. One window, in particular, was intended to create a prismatic rainbow effect on the floor when light flowed through it – of course, the window ended up on an interior wall, and thus the effect was never achieved. Even more luxurious than the fixtures was the plumbing an electrical work. Rare for the time, the Winchester Mystery House boasted indoor plumbing, including coveted hot running water, and push-button gas lighting available throughout the home. Additionally, forced-air heating flowed throughout the house. Adding further to the mysterious features, the prime numbers 7, 11, and 13 are repeatedly displayed in various ways throughout the House—the number 13 being most prominent. These numbers consistently show up in the number of windows in many of the rooms, or the number of stairs in the staircases, or the number of rails in the railings, or the number of panels in the floors and walls, or the number of lights in a chandelier, etc. Unquestionably, these three prime numbers were extremely important to Sarah. In 1906 something happened that would change the landscape of california and the Winchester house. The 1906 San Francisco earthquake struck the coast of Northern California at 5:12 a.m. on Wednesday, April 18 with an estimated moment magnitude of 7.9 and a maximum Mercalli intensity of XI (Extreme). High-intensity shaking was felt from Eureka on the North Coast to the Salinas Valley, an agricultural region to the south of the San Francisco Bay Area. Devastating fires soon broke out in the city and lasted for several days. More than 3,000 people died. Over 80% of the city of San Francisco was destroyed. The events are remembered as one of the worst and deadliest earthquakes in the history of the United States. The death toll remains the greatest loss of life from a natural disaster in California's history and high on the lists of American disasters. Although The impact of the earthquake on San Francisco was the most famous, the earthquake also inflicted considerable damage on several other cities. These include San Jose and Santa Rosa, the entire downtown of which was essentially destroyed. Since if the damage in San Jose was located at, you guessed it, the Winchester house. Standing 7 stories at the time, the house was damaged badly and the top three floors were essentially reduced and the house said at for stories from then on due to the damage. Aside from its immense size and Victorian style architecture, the House has a number of unique characteristics. To begin, it is undeniably a labyrinth. There are literally miles of maze-like corridors and twisting hallways, some of which have dead ends—forcing the traveler to turn around and back-up. There are also some centrally located passages and stairways that serve as shortcuts allowing a virtual leap from one side of the House to the other. Traversing the labyrinth is truly dizzying and disorienting to one’s sensibilities. The House abounds in oddities and anomalous features. There are rooms within rooms. There is a staircase that leads nowhere, abruptly halting at the ceiling. In another place, there is a door which opens into a solid wall. Some of the House’s 47 chimneys have an overhead ceiling—while, in some places, there are skylights covered by a roof—and some skylights are covered by another skylight—and, in one place, there is a skylight built into the floor. There are tiny doors leading into large spaces, and large doors that lead into very small spaces. In another part of the House, a second story door opens outward to a sheer drop to the ground below. Moreover, upside-down pillars can be found all about the House. Many visitors to the Winchester mansion have justifiably compared its strange design to the work of the late Dutch artist M.C. Escher. Practically a small town unto itself, the Winchester estate was virtually self sufficient with its own carpenter and plumber’s workshops along with an on-premise water and electrical supply, and a sewage drainage system. On September 5, 1922, she died in her sleep of heart failure. A service was held in Palo Alto, California, and her remains lay at Alta Mesa Cemetery until they were transferred, along with those of her sister, to New Haven, Connecticut. She was buried next to her husband and their infant child in Evergreen Cemetery, New Haven, Connecticut. She left a will written in thirteen sections, which she signed thirteen times. In accordance with her will Sarah had her entire estate divided up in generous portions to be distributed among a number of charities and those people who had faithfully spent years in her service. Her favorite niece and secretary, Marian Marriott, oversaw the removal and sale of all of Sarah’s furnishings and personal property. Roy Lieb, Mrs. Winchester’s attorney of many years, had been named in her will as executor to her estate. He sold the House to the people who, in 1933, preserved it as a “living” museum—today, it is known as the Winchester Mystery House also known as California Historical Landmark #868. Although no mention has ever surfaced as to any specific guidelines or special instructions by which Mr. Lieb would select a buyer for the property, one gets the distinct impression that Sarah wanted the House to stand intact and perpetually preserved… and so it does. SOME OF THE FOLKLORE Some of this stuff we've touched on already but here's a rundown of the folklore behind the house. Despite the fact that Sarah Winchester was extremely secretive about herself, nearly all of what the public thinks it knows about her reads like a mish-mash of gossip out “The National Enquirer.” some refer to this body of misinformation as “The Folklore.” Indeed, on a research visits to the Winchester Mystery House, a senior tour guide informed one writer that “in the old days, the tour guides were encouraged to make up stuff just to give some spice to the story.” The Folklore about Sarah says that, after William’s death in 1881, the highly distraught Mrs. Winchester sought the advice of the then famous Boston medium Adam Coons. During a séance with Coons, Sarah was told that because of the many people who had been slain by the Winchester Rifle, she was cursed by the Winchester fortune. Coons further instructed Sarah that the angry spirits demanded that she move to California and build them a house. Upon her arrival in California, Sarah began holding her own séances every midnight so that she could receive the next day’s building instructions from the spirits. Her séances allegedly involved the use of a Ouija board and planchette, and 13 various colored robes she would ritualistically wear each night (for the edification of the spirits) within the confines of her “Séance Room.” To further appease the angry spirits, Mrs. Winchester made sure the construction of the House went on, nonstop, 24 / 7, 365 days a year for fear that should the building ever stop, she would die. For some inexplicable reason, however, Mrs. Winchester took precautions in the building design so as to incorporate all of the strange features of the House to “confuse the evil spirits.” Moreover, she would ring her alarm bell every night at midnight to signal the spirits that it was séance time, and then again at 2:00 am, signaling the spirits that it was time to depart. Which begs the question “who was in charge of whom?” And, why would spirits’ have an inability or need to keep track of time? Whenever people make mention of Sarah Winchester the typical response you get from people is “Oh yeah…wasn’t she the crazy lady who built that weird house because she was afraid the spirits would kill her?” Many of these people have never been to the Winchester House. Their source is usually television. “ America ’s Most Haunted Places” tops the list of TV shows that grossly reinforces the Folklore of the house. The misinformation is further compounded by the “Haunted House” tour business thriving in San Jose as the commercial enterprise known as the “Winchester Mystery House” which profits by perpetuating the Folklore myth. In fairness to the management of the “WMH,” they try to present Mrs. Winchester in a positive light. However, their Halloween flashlight tours, along with booklets, postcards, coffee mugs and other sundry items being sold in the WMH souvenir shop displaying the title “The Mansion Designed By Spirits” only enhances the Folklore version of Sarah Winchester’s life. You’ve got to hand it to them, they’ve created a highly effective marketing strategy for a very lucrative commercial enterprise. These are good people who mean well—but this is hardly the legacy Sarah wanted to leave to posterity. Even in more recent times the house keeps giving up secrets. In 2016, a secret attic was discovered. Inside the attic were a pump organ, a Victorian-era couch, a dress form, a sewing machine, and various paintings. There was a rumour that Sarah had a secrecy room full of undisplayed treasures and large amounts of cash, it was thought this attic may have been that room but there is no concrete proof of this. So these are the stories about Sarah Winchester and her house, now comes the sad news, most of what you think you know, and most of what you've just heard, are myths. Stories that have grown over the years about the woman and the house. Early on we talked about president roosevelt trying to visit Sarah and the house. If you forgot, the story goes that Theodore Roosevelt attempted to visit Sarah at home in 1903, but was turned away. This is used as an example of her alleged weirdness. It is said the rumors likely started about Sarah because in life she was extremely private, refused to address gossip and did not engage much in the community. This infamous presidential visit never occurred. Eyewitness accounts state that the President's carriage never stopped at the Winchester place. Furthermore, Winchester had rented a house near San Francisco that year to prepare for the wedding of her niece. She was not at home. There is another myth that Sarah would spy on her employees. It is said that some employees believed Sarah could walk through walls and closed doors. The claims are that Sarah had elaborate spying features built into the house. There is no evidence she spied on her workers. Would a suspicious employer retain the same workers for decades? Would she name them in her will? Would she buy them homes? Would they name children after her? All these things happened. In short, there is no evidence that she ever spied on her employees. Then there is the fascination with the number 13 and several other numbers. Since websites detail the occurrences of 13 in the house: 13 robe hooks in the seance room, 13 panes of glass in several windows, a stairway with 13 steps, just to name a few. These facts are used as evidence to prove the woman was ruled by superstition. References to the number 13 were added after Sarah's death, according to workers at the time. The 13 hooks were added not long ago. Then we have some of the crazy architecture. The story goes that she built crazy things like hallways to nowhere, stairs to nowhere, doors that lead to walls, and doors that lead to several story drops, to confuse spirits. Some websites make much of the architectural "oddities" of the house, such as doors and flights of stairs leading into walls, and how they were supposedly built to confuse vengeful ghosts. Some say there is a more natural explanation—the 1906 earthquake. Research uncovered the fact that there was massive damage to the house in the trembler and that Sarah never fully repaired it. The stairs and doors that lead to "nowhere" are merely where damage has been sealed off or where landings have fallen away. After the earthquake she moved to another house. She did not want to make the necessary repairs—it had nothing to do with spirits. Not to mention she herself admitted that with her being the architect and having no formal training, things often did not go as planned. "I am constantly having to make an upheaval for some reason,” Winchester wrote to her sister-in-law in 1898. “For instance, my upper hall which leads to the sleeping apartment was rendered so unexpectedly dark by a little addition that after a number of people had missed their footing on the stairs I decided that safety demanded something to be done." Far from an exercise in spiritualism, Winchester’s labyrinth arose because she made mistakes — and had the disposable income to carry on making them. It didn’t help her reputation that she was naturally reserved. While most Bay Area millionaires were out in society, attending galas and loudly donating to charities, Winchester preferred a quiet life with the close family who occasionally lived with her. In the absence of her own voice, locals began to gossip. One of the biggest myths however is the stories of how construction started and kept in going 24-7. There were actually many instances of Sarah sending workers away. Many times in the summer months she would send them away for a couple months because it got too hot. And in the winter she would send them away for a little break for everyone. This has been uncovered in Sarah's own writings. The Feb. 24, 1895 issue of the San Francisco Chronicle ran an article that almost single-handedly laid the foundation for the Winchester Mystery House legend."The sound of the hammer is never hushed,” it reported. “... The reason for it is in Mrs. Winchester's belief that when the house is entirely finished she will die." So aside from appeasing spirits with the continued building this article states that she believes that if she ever finished the house that's when she would die, so that's why she kept building. "Whether she had discovered the secret of eternal youth and will live as long as the building material, saws and hammers last, or is doomed to disappointment as great as Ponce de Leon in his search for the fountain of life, is a question for time to solve,” the story concludes. Some modern-day historians speculate one of the reasons Winchester kept building was because of the economic climate. By continuing construction, she was able to keep locals employed. In her unusual way, it was an act of kindness. "She had a social conscience and she did try to give back," Winchester Mystery House historian Janan Boehme told the Los Angeles Times in 2017. "This house, in itself, was her biggest social work of all." As far as all of the supernatural talk, most of it started after her death. The famed Winchester mansion fell into the hands of John H. Brown, a theme park worker who designed roller coasters. One of his inventions, the Backety-Back coaster in Canada, killed a woman who was thrown from a car. After her death, the Browns moved to California. When the Winchester house went up for rent, Brown and his wife Mayme jumped at the chance and quickly began playing up the home’s strangeness. Less than two years after Sarah Winchester’s death, newspapers were suddenly beginning to write about the mansion’s supernatural powers. “The seance room, dedicated to the spirit world in which Mrs. Winchester had such faith, is magnificently done in heavy velvet of many colors,” the Healdsburg Tribune wrote in 1924. “... Here are hundreds of clothes hooks, upon which hang many costumes. Mrs. Winchester, it is said, believed that she could don any of these costumes and speak to the spirits of the characters of the area represented by the clothing.” (It is worth noting here: There are no contemporary accounts of Winchester holding seances in the home, and “Ghostland” writes that the “seance room” was actually a gardener’s private quarters.) The myth took hold, though, and the home, with its dead ends and tight turns, is easy to imagine as haunted. Although the spirits are fun, the ghosts shroud the real life of a fascinating, creative woman. Winchester was "as sane and clear headed a woman as I have ever known,” her lawyer Samuel Leib said after her death. “She had a better grasp of business and financial affairs than most men." Speaking of supernatural, let's get into the haunted history. Dozens of psychics have visited the house over the years and most have come away convinced, or claim to be convinced, that spirits still wander the place. It was even named one of the “Most Haunted Places in the World” by Time magazine. Here are just a few tales, courtesy of Winchester tour manager Janan Boehme. The Case of the Ghostly Handyman Some of Sarah Winchester’s loyal workmen and house servants may still be looking after the place, according to sightings of figures or the “feeling of a presence” reported many times over the years, by tour guides and visitors alike. One frequent apparition is a man with jet-black hair believed to have been a former handyman. He’s been seen repairing the fireplace in the ballroom, or pushing an equally spectral wheelbarrow – if wheelbarrows indeed linger in the beyond — down a long, dark hallway. The Secret of the Invisible HandSeveral years ago, a man working on one of the many restoration projects in the mansion started his day early in a section with several fireplaces, known as the Hall of Fires. The house was dead quiet before tours got underway, and he was working up on a ladder when he felt someone tap him on the back. He turned to ask what the person wanted. No one was there. Reassuring himself he’d just imagined the sensation, he went back to his work, only to experience what felt like someone pushing against his back. That was enough. He hurried down the ladder, crossed the estate and started on another project, figuring that someone — or something — didn’t want him working in the Hall of Fires that day. The Sign of the Heavy SighA tour guide named Samantha recently led visitors to the room the Daisy Bedroom, where Sarah Winchester was trapped during the 1906 quake. Samantha was about to begin her spiel when a very clear “sigh” came from the small hallway outside the bedroom door. Thinking one of her guests had merely fallen behind, Samantha turned to call the person into the room but saw no one. Then, as her eyes adjusted to the darkened hallway, she did see something. The form of a small, dark person slowly emerged, gliding around a corner. Samantha quickly stepped around the corner and again saw nothing but heard yet another deep sigh. She felt sure it was the tiny form of Sarah Winchester herself, perhaps peeved to find people in her favorite bedroom. You can find a surveillance video that seems to show a ghost or something moving around in a balcony late ate night on the fourth floor. Just as unexpected things turn up on video, the same is true of photographs. The Winchester Mystery House's own Public Relations Coordinator reports that he took several photos of the mansion in 2015. When he downloaded the photos he deleted what he didn't need. But, one caught his eye. In one window of the house, Tim O'Day spotted something. Was it a shadow? A reflection of a cloud? Or something else? Visitors to the Winchester Mystery House also report taking photos with strange shapes in the windows. A few even shared their snapshots on Facebook. If you visit, study all photos carefully before hitting the delete button. You never know what you will find! Top haunted house movies from ranker.com https://www.ranker.com/list/the-best-haunted-house-movies/ranker-film?ref=collections_btm&l=367358&collectionId=2164
這集我們錄到一半碰到了近期最有感的一次地震，嚇歪﹌﹌，這集也是我們的美國生活系列，在這之前有聊到PG，Bryant還是覺得為什麼PG沒有滾，然後隔天PG就跟快艇簽約了哈哈!! (00:26) 又開了很多次場~, (04:55) WMH錄完後剪輯都超多, (07:59) 籃球話題聊一下, (13:56) 地震來了!!!!!!, (17:40) 美國生活系列，聊一聊聊到教育方式?, (24:50) 感謝在學校對我們非常照顧的老師, (33:20) Jeff分享上課經驗和不去考試整班拿A+, (39:20) 推歌時間囉~ Kodak Black feat. PNB Rock - Too Many Years、LANY - cowboy in LA，等各未來留言看喜不喜歡我們推的歌~ 最後記得幫我們推薦出去和評分五星撞爆!!!!!!!!!!!!!!!!!!!!!!!!!!!
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.29.360552v1?rss=1 Authors: Dadar, M., Miyasaki, J., Duchesne, S., Camicioli, R. Abstract: Background: Freezing of gait (FOG) is a common symptom in Parkinsons Disease (PD) patients. Previous studies have reported relationships between FOG, substantia nigra (SN) degeneration, dopamine transporter (DAT) concentration, as well as amyloid {beta} deposition. However, there is a paucity of research on the concurrent impact of white matter damage. Objectives: To assess the inter-relationships between these different co-morbidities, their impact on future FOG and whether they act independently of each other. Methods: We used baseline MRI and longitudinal gait data from the Parkinson's Progression Markers Initiative (PPMI). We used deformation based morphometry (DBM) from T1-weighted MRI to measure SN atrophy, and segmentation of white matter hyperintensities (WMH) as a measure of WM pathological load. Putamen and caudate DAT levels from SPECT as well as cerebrospinal fluid (CSF) amyloid {beta} were obtained directly from the PPMI. Following correlation analyses, we investigated whether WMH burden mediates the impact of amyloid {beta} on future FOG. Results: SN DBM, WMH load, putamen and caudate DAT activity and CSF amyloid {beta} levels were significantly different between PD patients with and without future FOG (p < 0.008). Mediation analysis demonstrated an effect of CSF amyloid {beta} levels on future FOG via WMH load, independent of SN atrophy and striatal DAT activity levels. Conclusions: Amyloid {beta} might impact future FOG in PD patients through an increase in WMH burden, in a pathway independent of Lewy body pathology. Copy rights belong to original authors. Visit the link for more info
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.17.343574v1?rss=1 Authors: Hotz, I., Deschwanden, P. F., Liem, F., Merillat, S., Kollias, S., Jäncke, L. Abstract: White matter hyperintensities of presumed vascular origin (WMH) are frequently found in MRIs of patients with various neurological and vascular disorders, but also in healthy elderly subjects. Although automated methods have been developed to replace the challenging task of manually segmenting the WMH, there is still no consensus on which validated algorithm(s) should be used. In this study, we validated and compared three freely available methods for WMH extraction: FreeSurfer, UBO Detector, and the Brain Intensity AbNormality Classification Algorithm, BIANCA (with the two thresholding options: global thresholding vs. LOCally Adaptive Threshold Estimation (LOCATE)) using a standardized protocol. We applied the algorithms to longitudinal MRI data (2D FLAIR, 3D FLAIR, T1w sMRI) of cognitively healthy older people (baseline N = 231, age range 64 - 87 years) with a relatively low WMH load. As a reference for the segmentation accuracy of the algorithms, completely manually segmented gold standards were used separately for each MR image modality. To validate the algorithms, we correlated the automatically extracted WMH volumes with the Fazekas scores, chronological age, and between the time points. In addition, we analyzed conspicuous percentage WMH volume increases and decreases in the longitudinal data between two measurement points to verify the segmentation reliability of the algorithms. All algorithms showed a moderate correlation with chronological age except BIANCA with the 2D FLAIR image input only showed a weak correlation. FreeSurfer fundamentally underestimated the WMH volume in comparison with the gold standard as well as with the other algorithms, and cannot be considered as an accurate substitute for manual segmentation, as it also scored the lowest value in the DSC compared to the other algorithms. However, its WMH volumes correlated strongly with the Fazekas scores and showed no conspicuous WMH volume increases and decreases between measurement points in the longitudinal data. BIANCA performed well with respect to the accuracy metrics - especially the DSC, H95, and DER. However, the correlations of the WMH volumes with the Fazekas scores compared to the other algorithms were weaker. Further, we identified a significant amount of outlier WMH volumes in the within-person change trajectories with BIANCA. The WMH volumes extracted by UBO Detector achieved the best result in terms of cost-benefit ratio in our study. Although there is room for optimization with respect to segmentation accuracy (especially for the metrics DSC, H95 and DER), it achieved the highest correlations with the Fazekas scores and the highest ICCs. Its performance was high for both input modalities, although it relies on a built-in single-modality training dataset, and it showed reliable WMH volume estimations across measurement points. Copy rights belong to original authors. Visit the link for more info
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.04.283200v1?rss=1 Authors: Kumral, D., Cesnaite, E., Beyer, F., Hofmann, S. M., Hensch, T., Sander, C., Hegerl, U., Haufe, S., Villringer, A., Witte, V., Nikulin, V. Abstract: Objective: To investigate whether regional white matter hyperintensities (WMHs) relate to alpha oscillations (AO) in a large population-based sample of elderly individuals. Methods: We associated voxel-wise WMHs from high-resolution 3-Tesla MRI with neuronal alpha oscillations (AO) from resting-state multichannel EEG at sensor (N=907) and source space (N=855) in older participants of the LIFE-Adult study (60-80 years). In EEG, we computed relative alpha power (AP), individual alpha peak frequency (IAPF), as well as long-range temporal correlations (LRTC) that represent dynamic properties of the signal. We implemented whole-brain voxel-wise regression models to identify regions where parameters of AO were linked to probability of WMH occurrence. We further used mediation analyses to examine whether WMH volume mediated the relationship between age and AO. Results: Higher prevalence of WMHs in the superior and posterior corona radiata was related to elevated relative AP, with strongest correlations in the bilateral occipital cortex, even after controlling for potential confounding factors. The age-related increase of relative AP in the right temporal brain region was shown to be mediated by total WMH volume. Conclusion: A high relative AP corresponding to increased regional WMHs was not associated with age per se, in fact, this relationship was mediated by WMHs. We argue that the WMH-associated increase of AP reflects a generalized and likely compensatory spread of AO leading to a larger number of synchronously recruited neurons. Our findings thus suggest that longitudinal EEG recordings might be sensitive to detect functional changes due to WMHs. Copy rights belong to original authors. Visit the link for more info
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.27.270033v1?rss=1 Authors: Wheater, E. N., Shenkin, S. D., Munoz Maniega, S., Valdes Hernandez, M., Wardlaw, J., Deary, I., Bastin, M. E., Boardman, J. P., Cox, S. R. Abstract: Birth weight, an indicator of fetal growth, is associated with cognitive outcomes in early life and risk of metabolic and cardiovascular disease across the life course. Cognitive ability in early life is predictive of cognitive ability in later life. Brain health in older age, defined by MRI features, is associated with cognitive performance. However, little is known about how variation in normal birth weight impacts on brain structure in later life. In a community dwelling cohort of participants in their early seventies we tested the hypothesis that birthweight is associated with the following MRI features: total brain (TB), grey matter (GM) and normal appearing white matter (NAWM) volumes; whiter matter hyperintensity (WMH) volume; a general factor of fractional anisotropy (gFA) and peak width skeletonised mean diffusivity (PSMD) across the white matter skeleton. We also investigated the associations of birthweight with cortical surface area, volume and thickness. Birthweight was positively associated with TB, GM and NAWM volumes in later life ({beta} [≥] 0.194), and with regional cortical surface area but not gFA, PSMD, WMH volume, or cortical volume or thickness. These positive relationships appear to be explained by larger intracranial volume rather than by age-related tissue atrophy, and are independent of body height and weight in adulthood. This suggests that larger birthweight is linked to increased brain tissue reserve in older life, rather than a resilience to age-related changes in brain structure, such as tissue atrophy or WMH volume. Copy rights belong to original authors. Visit the link for more info
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.07.28.208579v1?rss=1 Authors: Bordin, V., Bertani, I., Mattioli, I., Sundaresan, V., McCarthy, P., Suri, S., Zsoldos, E., Filippini, N., Mahmood, A., Melazzini, L., Laganà, M. M., Zamboni, G., Singh-Manoux, A., Kivimäki, M., Ebmeier, K. P., Baselli, G., Jenkinson, M., Mackay, C. E., Duff, E. P., Griffanti, L. Abstract: Large scale neuroimaging datasets present the possibility of providing normative distributions for a wide variety of neuroimaging markers, which would vastly improve the clinical utility of these measures. However, a major challenge is our current poor ability to integrate measures across different large-scale datasets, due to inconsistencies in imaging and non-imaging measures across the different protocols and populations. Here we explore the harmonisation of white matter hyperintensity (WMH) measures across two major studies of healthy elderly populations, the Whitehall II imaging sub-study and the UK Biobank. We identify pre-processing strategies that maximise the consistency across datasets and utilise multivariate regression to characterise sample differences contributing to study-level differences in WMH variations. We also present a parser to harmonise WMH-relevant non-imaging variables across the two datasets. We show that we can provide highly calibrated WMH measures from these datasets with: (1) the inclusion of a number of specific standardised processing steps; and (2) appropriate modelling of sample differences through the alignment of demographic, cognitive and physiological variables. These results open up a wide range of applications for the study of WMHs and other neuroimaging markers across extensive databases of clinical data. Copy rights belong to original authors. Visit the link for more info
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.07.24.219485v1?rss=1 Authors: Sundaresan, V., Zamboni, G., Rothwell, P. M., Jenkinson, M., Griffanti, L. Abstract: White matter hyperintensities (WMHs) have been associated with various cerebrovascular and neurodegenerative diseases. Reliable quantification of WMHs is essential for understanding their clinical impact in normal and pathological populations. Automated segmentation of WMHs is highly challenging due to heterogeneity in WMH characteristics between deep and periventricular white matter, presence of artefacts and differences in the pathology and demographics of populations. In this work, we propose an ensemble triplanar network that combines the predictions from three different planes of brain MR images to provide an accurate WMH segmentation. Also, the network uses anatomical information regarding WMH spatial distribution in loss functions for improving the efficiency of segmentation and to overcome the contrast variations between deep and periventricular WMHs. We evaluated our method on 5 datasets, of which 3 are part of a publicly available dataset (training data for MICCAI WMH Segmentation Challenge 2017 - MWSC 2017) consisting of subjects from three different cohorts. On evaluating our method separately in deep and periventricular regions, we observed robust and comparable performance in both regions. Our method performed better than most of the existing methods, including FSL BIANCA, and on par with the top ranking deep learning method of MWSC 2017. Copy rights belong to original authors. Visit the link for more info
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.07.07.191809v1?rss=1 Authors: Dadar, M., Potvin, O., Camicioli, R., Duchesne, S. Abstract: Introduction: Volumetric estimates of subcortical and cortical structures, extracted from T1-weighted MRIs, are widely used in many clinical and research applications. Here, we investigate the impact of the presence of white matter hyperintensities (WMHs) on FreeSurfer grey matter (GM) structure volumes and its possible bias on functional relationships. Methods: T1-weighted images from 1077 participants (4321 timepoints) from the Alzheimer's Disease Neuroimaging Initiative were processed with FreeSurfer version 6.0.0. WMHs were segmented using a previously validated algorithm on either T2-weighted or Fluid-attenuated inversion recovery (FLAIR) images. Mixed effects models were used to assess the relationships between overlapping WMHs and GM structure volumes and overal WMH burden, as well as to investigate whether such overlaps impact associations with age, diagnosis, and cognitive performance. Results: Participants with higher WMH volumes had higher overalps with GM volumes of bilateral caudate, cerebral cortex, putamen, thalamus, pallidum, and accumbens areas (P < 0.0001). When not corrected for WMHs, caudate volumes increased with age (P < 0.0001) and were not different between cognitively healthy individuals and age-matched probable Alzheimers disease patients. After correcting for WMHs, caudate volumes decreased with age (P < 0.0001), and Alzheimers disease patients had lower caudate volumes than cognitively healthy individuals (P < 0.01). Uncorrected caudate volume was not associated with ADAS13 scores, whereas corrected lower caudate volumes were significantly associated with poorer cognitive performance (P < 0.0001). Conclusions: Presence of WMHs leads to systematic inaccuracies in GM segmentations, particularly for the caudate, which can also change clinical associations. While specifically measured for the Freesurfer toolkit, this problem likely affects other algorithms. Copy rights belong to original authors. Visit the link for more info
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.06.12.147934v1?rss=1 Authors: Veldsman, M., Kindalova, P., Husain, M., Kosmidis, I., Nichols, T. Abstract: Objectives: White matter hyperintensities (WMHs) are considered macroscale markers of cerebrovascular burden and are associated with increased risk of vascular cognitive impairment and dementia. However, the spatial location of WMHs has typically been considered in broad categories of periventricular versus deep white matter. The spatial distribution of WHMs associated with individual cerebrovascular risk factors (CVR), controlling for frequently comorbid risk factors, has not been systematically investigated at the population level in a healthy ageing cohort. Furthermore, there is an inconsistent relationship between total white matter hyperintensity load and cognition, which may be due to the confounding of several simultaneous risk factors in models based on smaller cohorts. Methods: We examined trends in individual CVR factors on total WMH burden in 13,680 individuals (aged 45-80) using data from the UK Biobank. We estimated the spatial distribution of white matter hyperintensities associated with each risk factor and their contribution to explaining total WMH load using voxel-wise probit regression and univariate linear regression. Finally, we explored the impact of CVR-related WMHs on speed of processing using regression and mediation analysis. Results: Contrary to the assumed dominance of hypertension as the biggest predictor of WMH burden, we show associations with a number of risk factors including diabetes, heavy smoking, APOE {varepsilon}4/{varepsilon}4 status and high waist-to-hip ratio of similar, or greater magnitude to hypertension. The spatial distribution of WMHs varied considerably with individual cerebrovascular risk factors. There were independent effects of visceral adiposity, as measured by waist-to-hip ratio, and carriage of the APOE {varepsilon}4 allele in terms of the unique spatial distribution of CVR-related WMHs. Importantly, the relationship between total WMH load and speed of processing was mediated by waist-to-hip ratio suggesting cognitive consequences to WMHs associated with excessive visceral fat deposition. Conclusion: Waist-to-hip ratio, diabetes, heavy smoking, hypercholesterolemia and homozygous APOE {varepsilon}4 status are important risk factors, beyond hypertension, associated with WMH total burden and warrant careful control across ageing. The spatial distribution associated with different risk factors may provide important clues as to the pathogenesis and cognitive consequences of WMHs. High waist-to-hip ratio is a key risk factor associated with slowing in speed of processing. With global obesity levels rising, focused management of visceral adiposity may present a useful strategy for the mitigation of cognitive decline in ageing. Copy rights belong to original authors. Visit the link for more info
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.05.27.119586v1?rss=1 Authors: Dadar, M., Camicioli, R., Duchesne, S., Collins, D. L., for the Alzheimers Disease Neuroimaging Initiative Abstract: INTRODUCTIONCognitive decline in Alzheimers disease is associated with amyloid-{beta} accumulation, neurodegeneration and cerebral small vessel disease, but the temporal relationships between these factors is not well established. METHODSData included white matter hyperintensity (WMH) load, grey matter (GM) atrophy and Alzheimers Disease Assessment Scale-Cognitive-Plus (ADAS13) scores for 720 participants and cerebrospinal fluid amyloid (A{beta}1-42) for 461 participants from the Alzheimers Disease Neuroimaging Initiative. Linear regressions were used to assess the relationships between baseline WMH, GM, and A{beta}1-42 to changes in WMH, GM, A{beta}1-42, and cognition at one-year follow-up. RESULTSBaseline WMHs and A{beta}1-42 predicted WMH increase and GM atrophy. Baseline WMHs, GM, and A{beta}1-42 predicted worsening cognition. Only baseline A{beta}1-42 predicted change in A{beta}1-42. DISCUSSIONBaseline WMHs lead to greater future GM atrophy and cognitive decline, suggesting that WM damage precedes neurodegeneration and cognitive decline. Baseline A{beta}1-42 predicted WMH increase, suggesting a potential role of amyloid in WM damage. Research in ContextO_LISystematic Review: Both amyloid {beta} and neurodegeneration are primary pathologies in Alzheimers disease. White matter hyperintensities (indicative of presence of cerebrovascular disease) might also be part of the pathological changes in Alzheimers. However, the temporal relationship between white matter hyperintensities, amyloid {beta}, neurodegeneration, and cognitive decline is still unclear. C_LIO_LIInterpretation: Our results establish a potential temporal order between white matter hyperintensities, amyloid {beta}, neurodegeneration, and cognitive decline, showing that white matter hyperintensities precede neurodegeneration and cognitive decline. The results provide some evidence that amyloid {beta} deposition, in turn, precedes accumulation of white matter hyperintensities. C_LIO_LIFuture Directions: The current findings reinforce the need for future longitudinal investigations of the mechanisms through which white matter hyperintensities impact the aging population in general and Alzheimers disease patients, in particular. C_LI Copy rights belong to original authors. Visit the link for more info
This week on DMT, Sam and Jack discuss their weeks and also toy with the idea of becoming pro wrestlers, and dissect their first fan email and the impact of the derogatory use of the name "Karen" - Don't Miss This!
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.05.14.096677v1?rss=1 Authors: Hoagey, D. A., Lazarus, L. T. T., Rodrigue, K. M., Kennedy, K. M. Abstract: Even within healthy aging, vascular risk factors can detrimentally influence cognition, with executive functions (EF) particularly vulnerable. Fronto-parietal white matter (WM) connectivity in part, supports EF and may be particularly sensitive to vascular risk. Here, we utilized structural equation modeling in 184 healthy adults (aged 20-94 years of age) to test the hypotheses that: 1) fronto-parietal WM microstructure mediates age effects on EF; 2) higher blood pressure (BP) and white matter hyperintensity (WMH) burden influences this association. All participants underwent comprehensive cognitive and neuropsychological testing including tests of processing speed, executive function (with a focus on tasks that require switching and inhibition) and completed an MRI scanning session that included FLAIR imaging for semi-automated quantification of white matter hyperintensity burden and diffusion-weighted imaging for tractography. Structural equation models were specified with age (as a continuous variable) and blood pressure predicting within-tract WMH burden and fractional anisotropy predicting executive function and processing speed. Results indicated that fronto-parietal white matter of the genu of the corpus collosum, superior longitudinal fasciculus, and the inferior frontal occipital fasciculus mediated the association between age and EF. Additionally, increased systolic blood pressure and white matter hyperintensity burden within these white matter tracts contribute to worsening white matter health and are important factors underlying age-brain-behavior associations. These findings suggest that aging brings about increases in both BP and WMH burden, which may be involved in the degradation of white matter connectivity and in turn, negatively impact executive functions as we age. Copy rights belong to original authors. Visit the link for more info
Dr Cruse discusses increased testing availability at WMH and also talks about some ways that people can be forces for positivity in this time.
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.05.04.077040v1?rss=1 Authors: Dadar, M., Gee, M., Shuaib, A., Duchesne, S., Camicioli, R. Abstract: Introduction: Previous studies have found associations between grey matter atrophy and white matter hyperintensities (WMH) of vascular origin with cognitive and motor deficits in Parkinsons disease (PD). Here we investigate these relationships in a sample of PD patients and age-matched healthy controls. Methods: Data included 50 PD patients and 45 age-matched controls with T1-weighted and FLAIR scans at baseline, 18-months, and 36-months follow-up. Deformation-based morphometry was used to measure grey matter atrophy. SNIPE (Scoring by Nonlocal Image Patch Estimator) was used to measure Alzheimers disease-like textural patterns in the hippocampi. WMHs were segmented using T1-weighted and FLAIR images. The relationship between MRI features and clinical scores was assessed using mixed-effects models. The motor subscore of the Unified Parkinsons Disease Rating Scale (UPDRSIII), number of steps in a walking trial, and Dementia Rating Scale (DRS) were used respectively as measures of motor function, gait, and cognition. Results: Substantia nigra atrophy was significantly associated with motor deficits, with a greater impact in PDs (p
The Line of Sight crew is all together for probably the only time in June, and we have opinions! You won’t BELIEVE what Bret said. Join us for a rather unstructured look at Lock and Load, predictions for Iron Gauntlet, and Wild Speculation about all kinds of WMH related content.
We were in the studio with Floyd Heater, President of Warren Memorial Hospital, and Terri Mayes, Vice-President of Warren Memorial Hospital as part of our community health partnership with Valley Health. Terri told us about the hospital's recent Pathways to Excellence designation that was developed by the American Nurses Credentialing Center as means of recognizing organizations that foster a healthy workplace environment that allows nurses and other care providers to flourish. Currently, there are 173 hospitals worldwide that have achieved this recognition, and Warren is one of just four hospitals in Virginia. Staff at Warren Memorial Hospital formed eight different teams and spent more than two years preparing for the certification, which include lengthy documentation and online surveys; more than 50 staff members contributed to the final application, which was more than 2,000 pages. Official confirmation of Pathway to Excellence designation was received last summer, but a formal presentation is happening in Florida later this month. Being a Pathway of Excellence hospital has shown to improve patient and staff satisfaction; increase recruitment efforts and advance nursing standards. Floyd gave us a snapshot of the new facility: Approximately 177,000 square feet 36 private rooms 150 acre campus Projected cost: nearly $100 million Anticipated opening date: late 2020/early 2021 Emergency Department 18 ED rooms, with shell space for four additional rooms (an increase from 12 rooms) All private rooms that are larger 5 clinical decision beds, of which the current hospital has none. This designated area allows patients who do not need to be admitted but are not ready to be discharged to rest comfortably while providers continue to review test results and monitor and evaluate their medical condition. This type of care is both safer and more cost efficient to patients. Larger, more functional work space for providers and staff Spacious waiting room with separate family room for private consultations Enhanced space for emergency medical services personnel Improved wheelchair accessibility throughout the building Improved patient/visitor parking Medical/Surgical Unit 36 all private patient rooms. The current hospital has semi-private rooms. Rooms are larger with more spacious accommodations for family Each room has a private bathroom with shower that are easily accessible by wheelchairs Throughout the hospital and in patient rooms, large floor-to-ceiling windows provide beneficial natural light that invites nature in rather than blocking it out Surgical Services Surgical Services will feature three operating rooms, which includes a dedicated cardiac catheterization. The ORs, sterile core and physician/staff work areas are all more spacious which will allow us to continue expanding services and investing in advanced technology. Additional Campus Features An attached three-story medical building System of walking trails and green space/parks that will provide a safe and inviting setting aimed at encouraging more outdoor movement Finally, we discussed the upcoming Community Safety & Wellness Fair happening on Saturday, April 27, from 8am - Noon at Warren County High School. The event will feature more than 70 exhibitors, comprehensive blood work – basic panel is $45 and includes CBC & other tests are available for additional fees. Free screenings include: cardiac rhythm with Dr. Anne Kassira; blood pressure and BMI; hearing and vision; pulmonary fit test; and, vouchers for no-cost mammograms - these are limited in supply. Kids' activities include: teddy bear clinic (bring one or receive a new one while supplies last); healthy lifestyle challenge – complete exercises and enter into a drawings for fitness trackers; petting zoo; K-9 demos; free heart healthy breakfast from 8am - 11am; free bike helmets given to those who need one; plus, lots of door prizes and give aways. Download the flyer here: VH 2019 Wellness Expo Flyer After the show, we continued to talk about the new facility and Terri told us about Medication Disposal Day also happening on Saturday, April 27, 2019 (same day as the Expo) from 10am - 2pm at the Outpatient Center on Commerce Avenue where you can drive up and drop off your unused or expired medications. You can get those details here: WMH med disposal flier 2019
Part two of our interview with Diana Dersch is here! - she's a dancer of so many years, wife, mom of a 9-month old munchkin, WMH, grade exam graduate, and so much more. She indulges everyone's curiosities about her experience at the Mock Worlds, how she's training for Worlds, what her goals are moving forward, her experience with grade exams, and the advice she has for dancers. For teachers, this interview is valuable in how you approach and train your dancers as they get older, know their bodies, and refine their personal styles. Make sure to listen to Part 1 in Episode 12 first! Follow Diana @mrs.desch on Instagram ------------------------------------------------------------- Courtney Jay TCRG hosts TCRG to CEO Radio for Irish dance teachers, studio owners, and aspiring teachers/studio owners who want to learn teaching and business skills to succeed in their careers, impact more students, and raise the glass ceiling of their success! Based in Connecticut, USA, Courtney is passionate about teaching, entrepreneurship, and of course our amazing sport of Irish dance. TCRG to CEO Radio hopes to bring Irish dance professionals together, provide actionable tips and strategies you can easily implement, and share our stories & struggles to better our understanding of the realities of teaching and business ownership. SUBSCRIBE TO THE SHOW! FIND US ONLINE: WWW.COURTNEYJAYTCRG.COM/PODCAST FOLLOW ON INSTAGRAM: @COURTNEYJAY_TCRG FACEBOOK GROUP: WWW.FACEBOOK.COM/GROUPS/TCRGTOCEO
Wow, wow, wow! I can't wait for you to listen to this two-part interview with Diana Dersch - dancer of so many years, wife, mom of a 9-month old munchkin, WMH, grade exam graduate, and so much more. She indulges everyone's curiosities about what she has learned dancing in many schools in three different regions, competing in every US region, how she handled dancing pre and post pregnancy, and all about how she created her signature look. Mentioned in the show: Nose breathing: https://www.facebook.com/justin.thompson.5095110/videos/10160946134775246/ Follow Diana @mrs.dersch on Instagram ------------------------------------------------------------- Courtney Jay TCRG hosts TCRG to CEO Radio for Irish dance teachers, studio owners, and aspiring teachers/studio owners who want to learn teaching and business skills to succeed in their careers, impact more students, and raise the glass ceiling of their success! Based in Connecticut, USA, Courtney is passionate about teaching, entrepreneurship, and of course our amazing sport of Irish dance. TCRG to CEO Radio hopes to bring Irish dance professionals together, provide actionable tips and strategies you can easily implement, and share our stories & struggles to better our understanding of the realities of teaching and business ownership. SUBSCRIBE TO THE SHOW! FIND US ONLINE: WWW.COURTNEYJAYTCRG.COM/PODCAST FOLLOW ON INSTAGRAM: @COURTNEYJAY_TCRG FACEBOOK GROUP: WWW.FACEBOOK.COM/GROUPS/TCRGTOCEO
Join Bret, Sabra, and Jaden for a rolicking good time full of laughter, salt, good natured ribbing, and endless tangents as we discuss the only thing that the apex predator of WMH currently has to worry about - Skorne.
April 18th 2018 at 12 Noon Pacific/3PM Eastern our special guests are Theodore R. Willich and Matt Berseth of NLP Logix a behavioral analytics and predictive modeling company based in Jacksonville, Florida. Theodore R. Willich is CEO of NLP Logix with more than 20 years-experience founding and leading high-growth companies. Previous to NLP Logix, Ted was co-founder and COO of MDI, a start-up in the medical services industry that grew from zero to over $100 million in annual revenues over the course of 18 years. Matt Berseth is Lead Scientist at NLP Logix, he began his career working as an intern for Microsoft, which had recently acquired the Great Plains accounting software platform in Fargo, ND.Upon completing his masters in Computer Science, Matt moved to Jacksonville, Florida where he continued his software development career working for a number of healthcare, marketing and logistics companies, where his focus was in developing and deploying predictive modeling applications into a production environment. Topics will include: White Matter Hyperintensity (WMH) model co-developed with Mayo Join @PophealthWeek co-hosts Fred Goldstein, MS & Gregg Masters, MPH for a timely review of the impact of behavioral health on the social determinants of health, population health and the elusive pursuit of the triple aim.
Reis Paluso explains his journey becoming a Wim Hof Method Instructor, and talks about how powerful our minds are. He answers the questions we have on our WMH journey, and gives us insights into the practice of breath work, mindset/focus, and cold exposure.
079 | Acknowledging some of the industry’s best Welcome to another episode of Biotechnology Focus radio. I am your host, Michelle Currie, here to give you the lowdown on the Canadian biotech scene. Today, I will be discussing such topics as empathic distress, the top industry leaders that stood out from the pack this past year, a plausible link between white matter in the brain and Alzheimer’s, and how a multi-use drug could benefit those combatting esophageal cancer. +++++ Ever felt like you were picking up someone’s stress just from being around them? As if their experiences radiated and permeated your own mind? Well, studies being done at the Hotchkiss Brain Institute in the Cumming School of Medicine at the University of Calgary are studying precisely that. Researchers have been told by healthcare workers that empathic nuances seem to transfer from soldiers’ who suffer from PTSD to their partners or family members, despite never having served in the military. Jaideep Bains, PhD, and his team at the Hotchkiss Brain Institute (HBI) in the Cumming School of Medicine have discovered that stress transmitted from others can change the brain in the same way as real stress does. The research team studied the effects of stress in pairs of male or female mice. They removed one mouse from each pair and exposed it to a mild stress before returning it to its partner. They then examined the responses of a specific population of brain cells in each mouse, which revealed that networks in the brains of both the stressed mouse and naïve partner were altered in the same way. “There has been other literature that shows stress can be transferred — and our study is actually showing the brain is changed by that transferred stress,” says Toni-Lee Sterley, a postdoctoral fellow in Bains’s lab and the study’s lead author. “The neurons that control the brain’s response to stress showed changes in unstressed partners that were identical to those we measured in the stressed mice.” The researchers discovered that the activation of the neurons causes the release of a chemical signal that acts as an “alarm pheromone” from the mouse that alerts the partner. The partner who detects the signal can then in turn, alert additional members of the group. Bains adds, “What we can begin to think about is whether other people’s experiences or stresses may be changing us in a way that we don’t fully understand. The study also demonstrates that traits we think of as uniquely human are evolutionary conserved biological traits.” The study demonstrates that the effects of stress on the brain are reversed only in female mice following a social interaction. The residual effects of stress on neurons in females were cut almost in half following time spent with unstressed partners. However, this did not apply or ring true for males. If some of the effects of stress are erased through social interactions, but this benefit is limited to females, this may provide insights into how we design personalized approaches for the treatment of stress disorders in people. +++++ I would also like to acknowledge this year’s Biotechnology Focus top life sciences CEO picks from across the country. They are industry leaders who have stood out from the pack, and whose tenacity is extremely admirable. They have captured the attention of the Canadian biotech investment community and are the cream of the crop as Chief Executive Officers on the Canadian biotech scene. With the help of some leading Canadian biotech analysts and investors, we’ve put together a list of who we think the Top 5 CEOs who elevate their companies are. The criteria for making the list: They are CEOs who have delivered in the past and are with companies where they have a chance of delivering in the future. They aren’t necessarily leading the biggest companies, but rather, they qualify because they are the best leaders. Dr. Clarissa Desjardins is a co-founder of Clementia Pharmaceuticals and has been the president since its inception in 2010 and chief executive officer since 2012. Her company is a clinical-stage biopharmaceutical company that develops disease-modifying treatments for patients suffering from debilitating bone and other diseases. Cameron Piron is an industry-recognized leader and innovator in image-guided surgery. Although he is not a CEO, he has made a profound impact as a co-founder and president at Synaptive Medical – a company that is breaking ground with advanced medical devices, medical imaging and information science. Their BrightMatter technology combines surgical planning and navigation, robotic digital microscopy and informatics to create a family of devices to obtain patient data and retrieve it when needed the most. Dr. Ali Tehrani is a co-founder, president and chief executive officer of Zymeworks Inc., and an obvious choice for this year’s list. He has been an integral part of the success of Zymeworks, which continues to partner and flourish at a dizzying rate. The company’s lead clinical candidate, ZW25, is a Azymetric bispecific antibody that targets two distinct domains of the HER2 receptor resulting in multiple differentiated mechanisms of action. Carl Hansen started AbCellera working out of his laboratory at the University of British Columbia in 2012. He is the president and CEO of this privately held biotech company that provides enabling technologies for the discovery and development of monoclonal (mAb) therapies directly from natural immune cells. AbCellera’s lead technology is a proprietary single cell antibody discovery platform that provides researchers the opportunity to rapidly identify mAb therapeutic candidates from the natural immune repertoires of any species. Lloyd Segal, a veteran biotech executive, president and CEO of Repare Therapeutics was another indisputable choice for this list. Lloyd is an entrepreneur-in-residence at Versant Ventures, and from 2010-2016 was a managing partner at Persistence Capital Partners, a leading healthcare private equity investor. He held CEO roles at Caprion Pharmaceuticals, which he co-founded, Advanced Bioconcept and Thallion Pharmaceuticals, and has served as a director of several public and private corporations in the U.S. and Canada. Repare is developing new, precision oncology drugs for patients that target specific vulnerabilities of tumour cells. Its approach assimilates insights from several fields of cell biology including DNA repair and synthetic lethality. There was no shortage of great candidates for this year’s top biotech CEO picks. After so many outstanding nominations, it was hard to narrow it down to just five. Here are some of the Honourable mentions who just missed the cut: Roberto Bellini – President and CEO of Bellus Health Richard Glickman – Founder and CEO of Aurinia Pharmaceuticals Arun Menawat – CEO of Profound Medical Sammy Farah – President and CEO of Turnstone Biologics Anthony Cheung – President and CEO of enGene Inc. David Main – President and CEO of Aquinox Pharmaceuticals +++++ Scientists from Sunnybrook Hospital in Toronto have discovered that the white matter found in the brain chips away at memory by shrinking the brain and contributing more to dementia than previously thought. White matter hyperintensities (WMH) are bright spots on MRI scans – tissue in the brain that is wearing away due to effects of aging and vascular risk factors on the brain’s small vessels. The research, published in the February 2018 issue of the journal Neurology, showed that individuals with extensive small vessel disease had profound shrinking of the temporal lobe, an important brain region that is instrumental to learning and memory function. The study included over 700 participants of the Sunnybrook Dementia Study led by Dr. Sandra E. Black. The researchers’ analyses showed that shrinkage of the temporal lobe explained how WMH were associated with memory problems. WMH is associated with poor verbal recall more so due to temporal lobe shrinkage and deficits in recognition memory – the most sensitive and specific cognitive sign of Alzheimer’s disease – in people with Alzheimer’s disease and across other late-life dementia syndromes including post-stroke dementia. The researchers stress that small vessel disease is often a “silent” contributor to cognitive decline and dementia, as do large vessel strokes. Since small vessels are linked to brain shrinkage and memory problems it is important to recognize vascular brain disease as a potential “root cause” for dementia. +++++ Faculty of Medicine scientists at the University of British Columbia have discovered that a drug currently being tested for autoimmune disorders of the blood may also be a knight in shining armour for those with esophageal cancer. Shane Duggan, a postdoctoral fellow in the division of gastroenterology, and Dermot Kelleher, dean of the faculty of medicine, found that fostamatinib reduced the growth rate of esophageal adenocarcinoma in mice by at least 70 per cent compared to the control growth. Esophageal cancer has abysmal survival rates (only 14 per cent alive five years after diagnosis) and is a growing Canadian health concern. The scientists published their discovery in Cellular and Molecular Gastroenterology and Hepatology explaining their search for possible treatment targets for esophageal cancer – the sixth-leading cause of cancer-related mortality and second-deadliest form of cancer. Duggan and Kelleher conducted a screen of about 6,000 genes found in a cell that are known or emerging drug targets in a variety of diseases. They found about 300 druggable genes specific to esophageal cancer and using biopsies of esophageal cancer from Br itish Columbia, the U.K., and Ireland, they narrowed that list to three primary candidates. It was then that they noticed something surprising – the genes were more associated with immune cells than with the epithelial cells of the esophagus. Esophageal cancer is often preceded by a condition called Barrett’s esophagus, which results from gastroesophagealreflux disease (GERD). The reflux causes the inflammation and induces the esophageal tissue to transform into intestinal-like tissue. The immune cells unleashed by GERD may never fully depart from the esophagus, causing low-level inflammation that continues undetected and without symptoms. The transformed esophageal epithelial cells, after prolonged exposure to inflammation, seem to produce and become driven by a protein called spleen tyrosine kinase (SYK). Duggan and Kelleher then turned their attention to fostamatinib, an SYK inhibitor developed by San Francisco-based Rigel Pharmaceuticals Inc., which has shown promise in immune and lymphoproliferative disorders. Proving them right, their study expressed that the drug was very effective at stopping the growth of esophageal cancer in vitro and in mice models that had been implanted with human esophageal cancer cells. While the tumours expanded rapidly in the mice in the control group, there was virtually no growth of the tumours in the mice given fostamatinib. +++++ Well that wraps up another episode! As always, if you have any questions or comments, I would love to hear from you, so feel free to email me at press@promotivemedia.ca. In the meantime, thanks for listening and hope you have a great week ahead! From my desk to yours – this is Michelle Currie.
So we talk about how our year 2017 in WMH went and what we have planned for 2018. Also a bit of various warmachine talk and we discuss couple of ATC lists.
In this week's episode, Niki, Natalia, and Neil debate the police shooting in Dallas, the role of conventions in presidential politics, and the rise of anti-vaccine activism. Time stamps Dallas: 4:13 Conventions: 19:33 Vaccines: 35:23 WMH: 46:36
In this week's episode, Natalia, Neil, and Niki debate the politics of Brexit, the growing popularity of adult summer camps, and Donald Trump's missing campaign. Time stamps: Brexit: 3:15 Camps: 15:00 Campaign In Absentia: 30:38 WMH: 44:08
In this week's episode, Neil, Natalia, and Niki discuss the Orlando shooting, focusing on the city's history, the attack's place in multiple histories of violence, and the role of presidential empathy in response to national crises. Time stamps: Orlando History: 3:10 Histories of Violence: 16:57 Presidential Empathy: 30:49 WMH: 43:20
Background: Clinical subtypes of mild cognitive impairment (MCI) may represent different underlying aetiologies. Methods: This European, multicentre, memory clinic based study (DESCRIPA) of non-demented subjects investigated whether MCI subtypes have different brain correlates on MRI and whether the relation between subtypes and brain pathology is modified by age. Using visual rating scales, medial temporal lobe atrophy (MTA) (0–4) and white matter hyperintensities (WMH) (0–30) were assessed. Results: Severity of MTA differed between MCI subtypes (p,0.001), increasing from a mean of 0.8 (SD 0.7) in subjective complaints (n=77) to 1.3 (0.8) in nonamnestic MCI (n=93), and from 1.4 (0.9) in single domain amnestic MCI (n=70) to 1.7 (0.9) in multiple domain amnestic MCI (n=89). The association between MCI subtype and MTA was modified by age and mainly present in subjects .70 years of age. Severity of WMH did not differ between MCI subtypes (p=0.21). However, the combination of MTA and WMH differed between MCI subtypes (p=0.02) Conclusion: We conclude that MCI subtypes may have different brain substrates, especially in older subjects. Isolated MTA was mainly associated with amnestic MCI subtypes, suggesting AD as the underlying cause. In nonamnestic MCI, the relatively higher prevalence of MTA in combination with WMH may suggest a different pathophysiological origin.
Background: White matter hyperintensities (WMH) on MRI scans indicate lesions of the subcortical fiber system. The regional distribution of WMH may be related to their pathophysiology and clinical effect in vascular dementia (VaD), Alzheimer's disease (AD) and healthy aging. Methods: Regional WMH volumes were measured in MRI scans of 20 VaD patients, 25 AD patients and 22 healthy elderly subjects using FLAIR sequences and surface reconstructions from a three-dimensional MRI sequence. Results: The intraclass correlation coefficient for interrater reliability of WMH volume measurements ranged between 0.99 in the frontal and 0.72 in the occipital lobe. For each cerebral lobe, the WMH index, i.e. WMH volume divided by lobar volume, was highest in VaD and lowest in healthy controls. Within each group, the WMH index was higher in frontal and parietal lobes than in occipital and temporal lobes. Total WMH index and WMH indices in the frontal lobe correlated significantly with the MMSE score in VaD. Category fluency correlated with the frontal lobe WMH index in AD, while drawing performance correlated with parietal and temporal lobe WMH indices in VaD. Conclusions: A similar regional distribution of WMH between the three groups suggests a common (vascular) pathogenic factor leading to WMH in patients and controls. Our findings underscore the potential of regional WMH volumetry to determine correlations between subcortical pathology and cognitive impairment. Copyright (C) 2004 S. Karger AG, Basel.
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.04.14.039065v1?rss=1 Authors: Jaywant, A., Dunlop, K., Victoria, L. W., Oberlin, L., Lynch, C., Respino, M., Kuceyeski, A., Scult, M., Hoptman, M., Liston, C., O'Dell, M. W., Alexopoulos, G. S., Gunning, F. M. Abstract: White matter hyperintensities (WMH) are linked to cognitive control; however, the structural and functional mechanisms are largely unknown. We investigated the relationship between WMH-associated disruptions of structural connectivity, resting state functional connectivity (RSFC), and cognitive control in older adults. Fifty-eight cognitively-healthy older adults completed cognitive control tasks, structural MRI, and resting state fMRI scans. We estimated inferred, WMH-related disruptions in structural connectivity between pairs of subcortical and cortical regions by overlaying each participant's WMH mask on a normative tractogram dataset. For region-pairs in which structural disconnection was associated with cognitive control, we calculated RSFC between nodes in those same regions. WMH-related structural disconnection and RSFC in the cognitive control network and default mode network were both associated with poorer cognitive inhibition. These regionally-specific, WMH-related structural and functional changes were more strongly associated with cognitive inhibition compared to standard rating of WMH burden. Our findings highlight the role of circuit-level disruptions to the cognitive control network and default mode network that are related to WMH and impact cognitive control in aging. Copy rights belong to original authors. Visit the link for more info
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