Podcasts about Alois Alzheimer

Protect Your Brain: Insights on Alzheimer's Disease In this episode, Nic and Steve dive deep into Alzheimer's disease, discussing what it is, why it happens, and most importantly, what you can do about it! From the curious history of its discovery (shoutout to Alois Alzheimer and his plaques) to modern-day prevention tips. Discover the shocking truth about sugar, secondhand smoke, and sedentary living while getting the lowdown on brain-boosting heroes like omega-3s, turmeric, and even pomegranates. Your brain will thank you! As always, this information is not designed to diagnose, treat, prevent, or cure any condition and is for information purposes only. Please discuss any information in this podcast with your healthcare professional before making any changes to your current lifestyle.   Check out ATP Science's range of products at our online store - https://bit.ly/3DMItYH References for this podcast can be found in the description on YouTube here - https://youtu.be/grAEqNfsPaM  

In dieser Episode von "Doc on Air" widme ich mich einem Thema, das viele betrifft und oft zu wenig Beachtung findet: Demenz, insbesondere Alzheimer. Es ist alarmierend, dass die Zahl der Demenzkranken weltweit stetig zunimmt. Während 2010 noch etwa 36 Millionen Betroffene prognostiziert wurden, erwarten Experten bis 2030 über 120 Millionen Menschen mit demenziellen Erkrankungen. Dieser Anstieg ist nicht nur auf die Alterung der Bevölkerung zurückzuführen, sondern auch auf eine zunehmende Sensibilisierung für die Krankheit. Eine frühzeitige Diagnose und Therapie sind entscheidend, um die enormen Behandlungskosten, die 2010 weltweit bei etwa 600 Milliarden Dollar lagen, zu senken. Ich beginne mit der historischen Entwicklung der Alzheimer-Krankheit, die ihren Ursprung im frühen 20. Jahrhundert hat. Es war Alois Alzheimer, der 1901 die erste Patientin mit charakteristischen Symptomen beurteilte. Zunächst wurde die Erkrankung nicht einmal als Altersdemenz erkannt, was eine lange und schwierige Reise in der Forschung zur Folge hatte. Heute wissen wir, dass Alzheimer eine der häufigsten Formen von Demenz ist, aber auch, dass es zahlreiche andere Formen und Ursachen gibt, die nicht mehr ignoriert werden können. Im weiteren Verlauf der Episode erkläre ich die kognitiven und emotionalen Defizite, die mit Demenz einhergehen, sowie die biologischen Mechanismen, die dazu führen. Es ist bemerkenswert, dass Forscher über die Jahre wesentliche Fortschritte gemacht haben, auch wenn es noch viele offenen Fragen gibt. 1980 wurden die ersten Medikamente zur Symptomlinderung entwickelt, doch die gewünschten Erfolge blieben oft aus. Der Mangel an effektiven Behandlungsmöglichkeiten verdeutlicht, wie wichtig Prävention und Früherkennung sind. Die identifizierten Risikofaktoren wie Bewegungsmangel, Rauchen und eine ungesunde Ernährung spielen eine zentrale Rolle im Krankheitsverlauf. Ich erläutere auch die Bedeutung sozialer Interaktion und aktiver Teilhabe am Leben. Menschen, die sich zurückziehen oder keine geistigen und körperlichen Herausforderungen annehmen, haben ein erhöhtes Risiko, an Demenz zu erkranken. Präventive Maßnahmen wie geeignete Ernährung, regelmäßige Bewegung und soziale Aktivität sind demnach essenziell. Das Ziel ist es, die Lebensqualität und die Selbstständigkeit der betroffenen Personen möglichst lange zu erhalten. In der letzten Phase der Episode widme ich mich den bestehenden Therapieansätzen, sowohl medikamentösen als auch nicht-medikamentösen. Ich bespreche, wie wichtig eine individuelle Betreuung zu Hause ist und dass die Unterstützung durch Angehörige und Fachkräfte entscheidend für die Lebensqualität der Erkrankten ist. Es ist unerlässlich, dass wir uns als Gesellschaft mit den Herausforderungen der Demenz auseinandersetzen und Maßnahmen ergreifen, um die Lebensbedingungen der Betroffenen zu verbessern. Abschließend weise ich auf wichtige Ressourcen und Unterstützungsangebote hin, die jedem zur Verfügung stehen, um besser mit dieser komplexen Erkrankung umzugehen.

Dan Nation is a professor of gerontology and medicine at USC. His research focuses on vascular factors in the brain and how they affect memory decline and dementia in older adults. He joined us to talk about studying blood vessels in the brain to identify early signs of dementia and potential therapies to treat it. Transcript Speaker 1 (00:01): The variability in your blood pressure day to day, month to month, year to year, and sometimes even beat to beat–the variability in your blood pressure is predictive of dementia risk. So higher levels of blood pressure variability are bad, even if you have very well controlled blood pressure levels. And this is important because currently we only treat average blood pressure. There is no treatment for variability in blood pressure. So it's a new area that we should try to look into controlling to see if we can prevent dementia in people who have high variation, even if they're already treated for hypertension. Speaker 2 (00:45): From the USC Leonard Davis School of Gerontology, this is Lessons in Lifespan Health, a podcast about the science and scientists improving how we live and age. I'm Orli Belman, Chief Communications Officer. On today's episode: how Professor Dan Nation is studying blood vessels in the brain to identify early signs of dementia and potential therapies to treat it. Dan Nation is a professor of gerontology and medicine at USC. His research focuses on vascular factors in the brain and how they affect memory decline and dementia in older adults. Welcome to our podcast Dan, and thank you for being here today. Speaker 1 (01:26): Thanks for having me. Speaker 2 (01:28): I wanna start by asking you about blood vessels in our brain. Is there anything unique about the brain's vasculature system, and how did it become the focus of your research? Speaker 1 (01:39): Yeah, it's a great question. So there's actually several things that are unique about the brain vasculature. For one thing, just the number of blood vessels. So you might think about the larger vessels that you can see with the naked eye, but most of the vessels are microscopic. And we have so many blood vessels in the brain that there's actually one blood vessel for every neuron. So every brain cell basically has its own microscopic blood vessel. So it's billions and billions of blood vessels, and this is likely the case because the brain has an incredible need for blood flow to support its very high metabolic rate. And the brain cannot store energy unlike other tissues in the body, and so any energy that the neurons need, they have to get on the fly from blood. So there's a torrential amount of blood flow that's disproportionate to the size of the brain. Speaker 1 (02:34): In addition to that, blood is actually toxic to brain tissue. And so the neurons need a special environment to operate, and so that milieu has to be well controlled. So the blood contains proteins, cells, infectious agents, metals, ions–all of which, if it were to get into the actual brain compartment, would be very toxic and would cause degeneration of the brain cells, cell death. And so their brain has a special structure that divides the blood off from the brain. This doesn't exist in other parts of our body; it's called the blood brain barrier. So that has to have integrity in order for the brain to survive and function properly. In addition, because of that, the way waste products of regular cellular metabolism and so forth, any other toxins that are in the brain, the way that gets moved out of the brain is different than other parts of the body because the lymphatic system in the brain is really different because we have to have this blood-brain barrier. So for a number of different reasons, the vessels are special. A lot of it has to do with the blood-brain barrier because the separation of the blood from the brain means that all of the nutrients have to be pumped actively into the brain. And all of these, again, waste products have to be pumped actively out somehow. And so any dysfunction there could lead to the buildup of toxins in the brain, which would cause degeneration. Speaker 2 (04:11): So your PhD is in psychology, correct? Speaker 1 (04:14): Yeah, neuropsychology. Speaker 2 (04:15): Neuropsychology. So how did you get interested in the vascular system? Speaker 1 (04:19): Yeah, I actually have always studied the vascular system because I was in a neuroscience lab that was focused on relationship between behavior and cardiovascular disease and basically neurovascular function and in particular as a clinical neuropsychologist we're involved in treating patients with neurocognitive disorders of aging, like dementia of Alzheimer's disease. And so I became interested in how these neurovascular factors may contribute to those diseases and to cognitive decline from those experiences. Speaker 2 (04:54): This sounds like a very complex system. What happens to it as we age? Speaker 1 (04:58): So as we get older, most people will develop a number of different vascular changes or will be at risk for different age-related vascular diseases. The most common is hypertension or high blood pressure. As we get older, the odds of developing high blood pressure just go up and up, and ultimately if you live long enough, most people will develop hypertension at some point. The majority of people over the age 65 have high blood pressure. And so that has to do with changes in your overall vascular system that can lead to a hardening or stiffening of the arteries and development of specific changes in the way the blood vessels of the brain work, which can damage the blood-brain barrier, lead to leakage of blood into the brain, decreased blood flow to the brain. And also what we've found is that older adults, their micro blood vessels don't dilate as well, and so they need to be able to dilate in order to provide more blood flow as needed to support brain health. Speaker 2 (06:11): It sounds like you know a lot about what's happening and the inner workings of our brain. Have updated imaging technologies improved our understanding of the role of these small blood vessels, and what can you tell us about your research in this area? Speaker 1 (06:24): Yes, so brain MRI has been very useful because it's usually relatively non-invasive, and we can use MRI to actually study the functioning of these microscopic blood vessels that would be otherwise very difficult to study. And we can actually visualize some microscopic changes such as small bleeds in the brain because they have this blooming artifact on brain MR. So we can see things that are microscopic, and we can study how the blood vessels can dilate or constrict using brain MRI. And we can study whether anything is leaking from the blood into the brain using brain MRI. So there's a lot more that is happening in MRI science that we're constantly monitoring and trying to incorporate into our studies. So I think there will be further advances, and we'll be able to study brain blood vessels even better in the future. Speaker 2 (07:19): And when you look at brain blood vessels, are you looking , particularly, at these microscopic ones? Speaker 1 (07:24): Yeah, we study the blood flow through these microscopic vessels and also whether or not they're leaking the leakiness of these vessels. Speaker 2 (07:32): I listened to a talk you gave, and you mentioned something called a neurovascular unit. What role does that play in brain health or brain dysfunction? Speaker 1 (07:41): It's a relatively newer concept that sort of springs off of the fact that again, there's a blood vessel for every neuron in your brain. It becomes clear when you understand how dense the micro vasculature is in the brain, that really it can't be totally separated from the functioning of the neurons themselves. When an area of your brain becomes active and neurons increase their activity, they need more blood flow, more nutrients, more clearance of waste, more oxygenation. And so they actually send a signal to other cells that control how much blood flow is happening, how much blood flow is coming to the vessels. So the blood vessels and the neurons are connected and communicating with each other. And so it's become clear that there's really this micro organ that we call the neurovascular unit, which is comprised of the blood vessel cells themselves, the neurons and other support cells, astrocytes, pericytes. And so all these different cells work together as a unit to make sure that blood flow meets the neurons' metabolic demand. Speaker 2 (08:50): And when this isn't working correctly, why is early detection of dysfunction in this area so important? Speaker 1 (08:56): Yeah, it's extremely important because if you think about it, when you have a problem with the blood vessel that could predate the actual injury to the brain, you can have dysfunctional blood vessels, but that doesn't mean you have any brain damage yet. You just have vascular disease. The blood vessels have a disease happening within them, but that can ultimately lead to death of the brain tissue. And in the brain, once tissue is dead, those neurons died. They're not replaced, and the brain can kind of rewire itself, but it can't really regrow that brain tissue. So the idea is if you cannot detect the blood vessel problem before the brain injury has happened, then you could intervene and prevent irreversible brain damage. Speaker 2 (09:47): That sounds important. How would somebody know? How do you test for blood vessel function? Speaker 1 (09:52): So, as I mentioned, we're using brain MRI technology. We're also working on blood tests. There's different markers people are interested in. It's still, you know, at the research phase, but we have the ability to quantify how well your blood vessels are responding to stimuli, how much blood flow you have into sensitive areas of your brain that are very important for memory and other mental functions and whether those vessels are leaking, which could lead to, again, irreversible brain damage. Speaker 2 (10:27): What can we do to improve our vascular health? Speaker 1 (10:30): So the number one thing is, well first of all to monitor your vascular health through going to see your physician so that you can catch cardiovascular risk factors early. If your blood pressure is elevated, if you have a problem with your cholesterol levels, if you're pre-diabetic or diabetic, it's extremely important that those cardiovascular risk factors are caught early and are well controlled and treated right away. If they are, they're not likely to lead to brain damage, but if they're left untreated, then you have a very high risk of this ultimately damaging your brain. The other thing is basic stuff that you would do for heart health is also good for brain health. So things like a good healthy diet, exercise. Physical activity doesn't have to be running marathons. Moderate levels of physical activity are helpful for the blood vessels in your brain. Speaker 2 (11:31): That's certainly a message we've heard on this podcast before: what's good for the heart is good for the brain. I think most people are familiar with the idea of high or low blood pressure, but you're looking at something called blood pressure variability. What is that, and what do we know about its connection to dementia risk? Speaker 1 (11:48): Yeah, so as I mentioned, many people over the age of 65 are going to have high blood pressure, and those rates just go up and up. But the research has shown that once you're over 65, if you have high blood pressure, develop high blood pressure, and as long as it's being treated, your actual blood pressure level doesn't really correlate with dementia risk very much. I mean, it needs to be treated; that's important. We know that. But beyond that, where you're at with your blood pressure as an older adult hasn't been very predictive of things like brain degeneration, dementia. But what we've observed is that, even if you are treated and even if you are treated pretty aggressively, have have very low blood pressure with treatment, the variability in your blood pressure day to day, month to month, year to year, and sometimes even beat to beat the variability in your blood pressure is predictive of dementia risk. So higher levels of blood pressure variability are bad, even if you have very well controlled blood pressure levels. And this is important because currently we only treat average blood pressure. There is no treatment for variability in blood pressure. So it's a new area that we should try to look into controlling to see if we can prevent dementia in people who have high variation, even if they're already treated for hypertension. Speaker 2 (13:18): And are the traditional treatments effective? Has your research revealed anything about blood pressure medications and whether they can affect variability? Speaker 1 (13:27): Yeah, we're just now starting to do this work. It's complicated because there's many different things that affect blood pressure variability, and we need to do a lot more research. But it's already known that medications that are longer lasting, drugs that have a longer half-life or have longer term effects, for example, those tend to be better at keeping variability low in addition to keeping your blood pressure levels low. And that makes sense, right? If the drug is wearing off, you know, after a short period of time or by the end of the day, then you would expect to have more variation between doses. And so we plan to do more research on the different types of blood pressure medicines, the classes, specific agents, and we'll call their pharmacokinetic properties, how long they last in your blood, the half-life and so forth. But also adherence to blood pressure medication if people skip a dose or they're taking it at the wrong time of day–that kind of thing can also affect blood pressure variability. Speaker 2 (14:28): And is this research that's still in the lab stage, or is this informing clinical practice yet? Speaker 1 (14:36): Well it's clinical research,  so we're studying human beings, older adults from the community who are taking blood pressure medications and that kind of thing. So it should, you know, our findings will be of value to clinicians, I think. And they're very interested in anything as it relates to blood pressure medicines because they're dispensing these drugs all the time in such a common condition. Speaker 2 (14:58): We have talked to Mara Mather about heart rate variability in this podcast, and I know that's a big area of research for her. Is there a connection between heart rate variability and blood pressure variability? Speaker 1 (15:11): Yeah, they're different things, but they are connected in the sense that your body tries to maintain steady blood pressure. It's not necessarily a good thing to have your blood pressure fluctuating all the time. And one of the ways that that happens, just homeostatically with normal functioning of your physiology, is changes in heart rate can help to modulate blood pressure. So they are related in terms of your cardiovascular system, but they're distinct. High heart rate variability is probably a good thing in relation to better health, whereas high blood pressure variability is a bad thing. Speaker 2 (15:48): This is a little bit of a subject change, but can damage blood vessels repair or regenerate themselves? And what might this mean for cognitive decline? Speaker 1 (15:58): Yeah, so anytime you receive any kind of injury, including a brain injury, the blood vessels and the tissue goes through a regeneration, healing restoration process. And in this case, usually it's the branching of additional vessels off of the existing vasculature. This is a process called angiogenesis, generating new branch points off of the blood vessel. So, if somebody has a stroke for example, you're gonna have a large piece of brain tissue that has been destroyed by not getting any blood flow. There's going to be a healing process that's gonna happen there, and there's gonna be some regrowth of branches of neurons as the brain kind of rewires itself and people healing from a stroke. And that has to be supported by branching off of blood vessels. So I said the neurons are very dependent on blood flow. So they work together during wound healing. And so yes, we certainly have an interest in this process since it's likely ongoing if you have some kind of microvascular damage happening, and we wanna understand more about whether it could be of benefit or it could go wrong and potentially cause harm and so forth. So we're studying this angiogenesis process in people with cognitive impairment. Speaker 2 (17:18): And can you tell me a little bit about how you're studying it? Speaker 1 (17:21): Yes. So we have lots of different projects happening. We are studying these cells that are in your blood circulation and come from different parts of your body, and they're very important in this angiogenesis process. They can actually form new blood vessels to replace damaged or dysfunctional ones. And so we can take blood from, again, older adults in the community who may or may not have different levels of vascular damage in their brains. And we can grow these cells in a dish and try to better understand whether they're functioning well, whether they're able to form blood vessels the way they're supposed to or if there's something wrong with that process. Speaker 2 (18:06): Is this what you're talking about when you say growing a brain in the lab? Speaker 1 (18:09): Yeah, so I've partnered with a bioengineering team that grows these micro brains, little brains in a dish. And what we can do now, and this is our new initiative we just started, is we can take blood from our participants and actually grow their brain vasculature in a dish. So these brain micro vessels that we're studying with brain MRI, we can actually grow them in the dish from these blood samples because we can grow these specialized cells that I'm referring to. They'll grow blood vessels in a dish, and we can see how they function. Are they forming blood vessels that are leaking? Are they forming blood vessels that are not branching properly or have other kinds of dysfunctional properties that don't support blood flow and so forth? And then we can tie that back to what's happening with that person's brain MRI. Do they have leaky blood vessels in their brains? Do they have proper blood flow on brain MRI or not? And so by doing this process, we can actually, the goal is to develop this sort of personalized medicine approach to try and better diagnose and treat brain blood vessel problems. Speaker 2 (19:19): So everybody's brain grows differently in a dish depending on what you're putting in? Speaker 1 (19:25): Yeah, this is what we're testing. So just let me give you a concrete example. If somebody has cognitive impairment and we do a brain MRI and we see that, sure enough, they have leaky blood vessels, might it be the case that this regeneration process isn't working in that person? So we could take their blood and grow a little mini brain that has their brain blood vessels in it and see whether they're leaking or not. If they are leaking, then it suggests that perhaps there's something wrong with this regeneration process, and we can actually try out different drugs in the dish and treat that person's micro brain with different potential therapies and see if any of them work. And then that might give us a clue as to how to fix the problem. Speaker 2 (20:07): Wow, that's really exciting. Is there anything you wanna add or any of your other research studies that you wanna give us an overview of?  Speaker 1 (20:14): Yeah, I think the only other thing I would wanna highlight, something that I'm really excited about that we've made a number of discoveries on and are continuing to, and we actually have some papers just now coming out, is this connection between memory decline and dementia and the functioning of these tiny blood vessels, these micro vessels. We've continued to find that the memory centers in the brain, which are the same areas that are affected by Alzheimer's disease and that degenerate in neurodegenerative disease that causes a really bad memory problem and dementia in older adults, the microvessels in those areas are dysfunctional in people who are at genetic risk for Alzheimer's. And in people who have memory problems, we found that they're leaking. We found that they don't dilate properly when we give them a stimulus that's supposed to dilate the blood vessels. And in some cases they have decreased blood flow. And so it's important because it demonstrates that there is this connection between the micro vessel function and neuro degeneration, which has, I think, eluded the research committee for a long time. We've known that there's a connection between vascular disease and neurodegeneration, but that's something I'm very interested in unpacking. Speaker 2 (21:33): Just to follow up on that, I know we hear a lot about the plaques and the tangles that are associated with Alzheimer's disease. Where does the vascular system come into play with this? Is there a connection? Speaker 1 (21:44): Yeah, so the way we normally think about Alzheimer's disease is that it has, as you mentioned, these two proteins that build up. You could form the plaques and the tangles, but also ever since Alois Alzheimer first described the disease, he noticed that there were problems with the blood vessels, a condition called cerebral amyloid angiopathy, where there's also a buildup of toxic proteins in the blood vessels. And it's been noticed again over the decades that a lot of cardiovascular risk factors are also risk factors for Alzheimer's, but no one was able to quite figure out how the blood vessel changes relate to Alzheimer's disease. And I think it's only just now that we're able to study these micro vessels with newer technology, that we're understanding that the micro vasculature is probably where this link is occurring. And what we've found is that there's a connection to the tangles, the tangles that are happening inside the neurons that lead to degeneration of those neurons. When you have microvascular dysfunction, you tend to see that kind of degeneration happening. Speaker 2 (22:52): Wow. This is a really interesting window into a whole new research direction that we haven't learned about before. So thank you very much for joining us today and explaining it all to us. Speaker 1 (23:01): Thank you. Speaker 2 (23:03): That wraps up this Lesson in Lifespan Health. Thanks to Professor Dan Nation for his time and expertise and to all of you for choosing to listen. Join us next time for another Lesson in Lifespan Health, and please subscribe to our podcast at lifespan health.usc.edu. Lessons in Lifespan Health is supported by the Nay Center for Healthspan Science.

In this episode of The Mind Change Podcast's Emotional Drivers series, Heather McKean explores the emotional factors behind dementia and Alzheimer's disease, noting a significant 200% increase in dementia cases since 1990. She explains Alzheimer's as the most prevalent type of dementia, originating from Alois Alzheimer's discoveries in his patient, Auguste Deter. Heather discusses how emotional dissociation and the urge to suppress painful memories contribute to these conditions, with recent research linking Alzheimer's to metabolic issues like "type 3 diabetes." Dive in! Discover how addressing these emotional roots could potentially prevent and even reverse Alzheimer's.

Najpogostejša oblika demence je Alzheimerjeva bolezen, ki obsega več kot dve tretjini demenc. Gre za kronično napredujočo bolezen, ki jo je leta 1907 opisal Alois Alzheimer pri 51-letni ženski: ni se znašla v lastnem stanovanju, imela je spominske motnje in je bila sumničava. Demenca nastane zaradi bolezenskih sprememb v možganskih celicah. V sredinem svetovalnem servisu bo na vaša vprašanja odgovarjal prof. dr. Zvezdan Pirtošek, dr. med., specialist nevrolog s kliničnega oddelka za bolezni živčevja Univerzitetnega kliničnega centra v Ljubljani.

SHOW NOTES: Save the Brain: Lifestyle Medicine and Dementia Prevention In this episode of 'Healthy Looks Great On You,' Dr. Vickie Petz Kasper delves into the critical issue of dementia, a condition affecting millions worldwide. She emphasizes the importance of early detection and lifestyle changes in preventing and managing dementia, including Alzheimer's disease. Dr. Petz Kasper, drawing from her transformation through lifestyle medicine, shares the potential of exercise, restorative sleep, and dietary modifications like the MIND diet in preventing up to 40% of dementia cases. She highlights the dire need for social awareness around dementia, which currently impacts over six million Americans, with rates doubling over the past 20 years. The episode also dismantles misconceptions surrounding dementia, informs on recognizing early symptoms, and underlines the significance of modifications like hearing aids and engaging in regular physical activity. Moreover, it offers a deep dive into the evidence-supported MIND and Mediterranean diets and their role in neurodegenerative delay, alongside strategies for stress management, enhancing sleep quality, and fostering social connections to bolster brain health. 00:00 The Shocking Truth About Dementia Prevention 00:38 Welcome to Healthy Looks Great On You! 01:29 Understanding Dementia: More Than Just Memory Loss 03:24 Breaking the Stigma: It's Time to Talk About Dementia 07:04 The Science Behind Dementia: Types and Causes 14:59 Lifestyle Changes: The Key to Preventing Dementia 15:17 The MIND Diet: Your Brain's Best Friend 22:49 Exercise and Other Pillars of a Healthy Brain 25:56 The Don'ts: Avoiding Risk Factors for Dementia 28:02 Final Thoughts and Caregiver Support RESOURCES (may contain affiliate links) Previous episodes on high blood pressure, cutting out tobacco and alcohol, stress management and more can be found HERE To download card, MIND diet and MIND diet checklist, subscribe to emails HERE. You'll get weekly emails, plus 7-Day Prescription for Change. Next week's podcast episode is for caregivers and will include all downloads.  How Not to Die by Michael Gregor How Not to Die Cookbook  How Not to Diet by Michael Gregor Smoothie Blender Black Bean Brownie Recipe TRANSCRIPT: Did you know that lifestyle modifications such as exercise and restorative sleep and controlling blood pressure can prevent up to 40 percent of dementia cases in the world? Dementia is one of the most dreaded diagnoses, along with cancer. And just think, breast cancer and prostate cancer can be treated if caught early. But listen, it is just as important to treat and prevent dementia. Save your brain! Now is the time to make changes that may prevent the development of this terrible disease., , You're listening to Healthy Looks Great On You, a lifestyle medicine podcast. I'm your host, Dr. Vickie Petz Kasper. For two decades, I practiced as a board certified obstetrician gynecologist, navigating the intricate world of women's health. But life took an unexpected turn when my own health faltered. Emerging on the other side, I discovered the transformative power of lifestyle medicine. Now, I'm on a mission to share its incredible benefits with you, so buckle up because we are embarking on a journey to our very own mini medical school, where you'll learn how lifestyle medicine can help prevent, treat, and sometimes even reverse disease. This is episode 112, Save the Brain. When someone is diagnosed with dementia, it doesn't just affect the patient, but the caregivers and the entire family as well. It's likely you know someone with dementia because 1 in 3 seniors has been diagnosed with this. And when people think of dementia, they think about memory loss. But it's really much more than that.  It's also fatal resulting in the death of more people than breast and prostate cancer combined. In fact, it's the seventh leading cause of death in the United States. And do you think it seems like more and more people have dementia? Well, it's true. Over the last 20 years, deaths from dementia have doubled. By contrast, death from heart disease, which by the way is still the number one killer, have decreased over that same period of time. If you or a loved one is experiencing symptoms of dementia, don't feel alone. Right now, more than six million Americans have been diagnosed with dementia. And the numbers are rising sharply. About 33 percent of people over the age of 85 have some form of dementia. It's not part of the normal aging process and it doesn't affect everyone, but it is more common. Back in the old days, people said, they're just getting senile, but now we know so much more. 10 percent of the people over the age of 65 have symptoms of cognitive decline. Progress is slow and affects different people differently. Most people with dementia over the age of 65 live 4 to 8 years, but others live as long as 20. Typically, older people are affected, but not always. There are rare cases of early onset dementia that occur in midlife, which is particularly tragic, isn't it? But, people often don't seek treatment. Why do you think that is? Well, for one thing, there's a weird stigma associated with dementia. I mean, like, if your heart is failing, you'd tell your friends, right? But if your brain is failing, somehow that's embarrassing. But dementia is literally brain failure. Second, there's a misconception that nothing can be done. Ready for some good news? There is. While dementia cannot be cured, it is possible to slow progression. And prevention is also possible. And obviously, most important. How do you know if you're experiencing symptoms of dementia versus just being forgetful? Which can happen for a variety of reasons. Memory loss is a hallmark sign of dementia, but it's so much more. It's things like poor judgment. And this one is really dangerous, especially if people continue to drive. It can be dangerous in other situations as well. And I may or may not have a story about fireworks, catching a field on fire, and the fire department coming and, um, we really weren't sure who to blame, but we won't talk about that. Another symptom is confusion. People may think they're somewhere that they aren't. Or they may call people or their pets by the wrong name. And they may have trouble finding the word they need. Along with trouble writing. and understanding what they read. They may wander or get lost and have difficulty handling their finances, paying the bills and keeping up and writing checks. I mean, that's hard for everyone, but it can be so much worse if you're experiencing cognitive decline. Some people repeat the same question over and over. They may say, “When is my hair appointment?” And then five minutes later, “When is my hair appointment?” Sometimes they'll use unusual words to refer to familiar objects. Another key feature, which has only recently been brought to the forefront, is slowing down. People who used to walk really fast, suddenly walk slower. People who used to eat very fast, eat slower. And everyday tasks, like getting ready in the morning, take forever. Also, there can be a loss of interest in normal, everyday stuff. A change in appearance because the person may quit caring so much about their hygiene. For instance, someone who was meticulous about their hair suddenly quits brushing it. There can be hallucinations, delusions, or paranoia. A common one is, they took my money. And then they tell their friends and at first their friends don't notice that they're having problems and so they believe that someone took their money. Another thing is not caring about other people's feelings. They might say, “Look at that woman, she's ugly and her baby looks just like her.” That can be really embarrassing for the family members.  One thing that can help is to get little business cards that say, “Thank you for your patience. The person I am with has dementia.” I created a little template and I put a link in the show notes for you. Another thing that can happen is impulsiveness and this can be worse than a teenager. They may have trouble controlling their emotions and may experience a personality change. Someone who is usually really sweet may become mean and vice versa. They may have problems with balance or movement and this can be really dangerous because it can make them more likely to fall. And a lot of times the symptoms are not noticed by the person who has the cognitive decline but by their friends and family members. But nobody wants to talk about it. And that's unfortunate because this disease has a huge impact and it needs attention. Before I give you some good news about what can be done to prevent dementia or possibly even slow progression, we need to review some science. You didn't think you were getting out of mini medical school today, did you? First of all, what causes dementia? Well, that depends on the type. There are several different types of dementia, and the most common and most familiar is Alzheimer's. Now, pay attention closely. It's not Alzheimer's. It's AllTimer's. Well, that's a weirdly spelled word, isn't it? Turns out, it's somebody's name. A German man, to be exact. Alois Alzheimer was a psychiatrist who first described the disease in 1905. Good job. Think I would hate having my name associated with such a terrible disease. So if you insist on saying All Timers, I'll forgive you. Maybe. Not all dementia is Alzheimer's, but Alzheimer's is always dementia. Did I just hear you say, huh? Let me explain. Think of it this way. A poodle is a type of dog. And while all poodles are dogs, not all dogs are poodles. Got it? Alzheimer's is a type of dementia, but You're welcome. But not all dementia is Alzheimer's, there are other types. So what are the other types of dogs besides poodles? Well there are German Shepherds, Beagles, Dachshunds, oh wait, never mind, we were talking about types of dementia. But I hope that analogy helps you remember that not all dementia is Alzheimer's. Alzheimer's is a type of dementia. The others are things like frontotemporal dementia. Now that may sound familiar because of Bruce Willis, you know, the actor from Miami Vice who starred in the action packed Die Hard movies? His family announced that he had Frontotemporal Dementia. There's also Lewy Body Dementia that looks similar to Parkinson's Disease with shuffling, tremors, and hallucinations. It can be particularly devastating and it's rumored that that's what Robin Williams had. Vascular dementia is caused by disease in the blood vessels, like little mini strokes. And then there's mixed, where dementia is attributed to multiple causes. How do you determine which type of dementia is present? Well, it's not that easy. Lewy bodies are really specific, and they're a clump of protein that is found inside the brains of people with this type of dementia. The problem is, you can't see them, except on autopsy. And since it's related to Parkinson's There are clues to the diagnosis, like the inability to draw a clock face. This is a fascinating thing. Certain parts of the brain are responsible for certain cognitive tasks. So there are neurologic tests that can help your doctor make the right diagnosis. It starts with a complete medical history and physical exam, and there are specific memory and psychological tests that evaluate certain areas of the brain.  Some of these can take hours to complete, and that's exhausting. So a lot of people don't want to pursue it. But the doctor should check your reflexes, watch you walk, check for balance and sensation. Didn't you always wonder what that tuning fork was for? It's to see if the patient can feel vibration. And patients are sometimes diagnosed with depression. There are also mental performance tests that check memory and thinking skills. Imaging studies like MRI may be helpful, but they're not usually conclusive. The definitive way to check for Alzheimer's is a spinal tap because there are amyloid proteins in the cerebrospinous fluid. Now I know that sounds awful, but it's really not that bad. If you had an epidural when you had a baby, that's a much bigger needle than the one used for a spinal tap. Another symptom that some people have is confabulation. That's a really big word that means making up stories. But the tricky part is that some people are really good storytellers.  So good storytellers who get dementia may be able to tell fantastic stories. The trick is to know when they're telling the truth or not. At first, with dementia, the symptoms often wax and wane. And it's super easy to attribute it to something else. So, why do the symptoms come and go? Well, think of it like tangles in your hair. The neurons in your brain get tangles in them sometimes. Other times, thinking may be clear. Don't you wish we could just spray some no more tangles on the brain? Although, I'm not really sure that stuff worked well anyway. I remember it still hurting when my mom brushed my hair when I was little now, for people on Medicare, the annual wellness visit requires an assessment of cognitive function. And it can be very brief and simple. There are several different questions to choose from. So that may explain why sometimes your doctor is asking you weird questions. So, what's the point? Well, it's to identify people with cognitive decline in the earliest stages so that interventions can be made. And guess what the most effective interventions are? I hope you guessed lifestyle changes. There are medications that slow progression and there are some promising treatments on the horizon too. We'll talk about both later, but first just a little more terminology. MCI stands for mild cognitive impairment. And this is usually the first thing noticed by the patient, family, or friends. Don't panic, but this is stuff like losing your keys or your cell phone. Now, don't talk to my husband about how many times I lose my cell phone. But it's also forgetting important events or appointments, trouble coming up with words and forgetting names. Another thing is a loss of the sense of smell can happen with early disease. And of course that's become a lot more complicated in the era of COVID. But the key time for intervention is early disease or mild cognitive impairment. Oh wait, there's one thing even better, and that's prevention. Whether you are trying to arrest or slow progression or minimize your own risk, the treatment is the same. I promise we'll talk about that soon, but let's discuss who is at risk first. Women are at greater risk. Two thirds of people in the United States with Alzheimer's are women. For women at age 45, the lifetime risk is 1 in 5. And for men, it's 1 in 10. And not only are women at greater risk for developing the disease, they carry 70 percent of the caregiver burden. Older African Americans are at greater risk than older whites, and older Hispanics have a 1. 5 percent increase in rates of dementia compared to older whites. We often talk about modifiable risk factors versus non modifiable risk factors. Those are the ones you can't control, like your gender, ethnicity, or genetics. When we see a parent or a grandparent experience dementia, it feels like looking in a mirror at our own fate. But it doesn't have to be that way. Lifestyle interventions for prevention should begin as early as possible, even in childhood. In other words, if you're concerned about your family history, then make changes together with your whole family. Let's talk about modifiable risk. First of all, the number one preventable contributing factor to the development of dementia is wait for it. Hearing loss. Did you hear that? Now, you can't help it if you can't hear well, but by golly, you can get some hearing aids. I've had them for about six years and my hearing isn't terrible, but I don't want that part of my brain that processes hearing loss - the spoken language to start shrinking. So I wear them. Well, I wear them most of the time. All right. Now let's talk about lifestyle modifications. Whew, finally, right? All six pillars of lifestyle medicine are important in preventing cognitive decline. Diet, stress management, exercise, social connectedness, minimizing harmful substances, and restorative sleep. First, let's talk about diet. Hmm, you probably knew that was coming. There is some evidence that the MIND, M- I -N -D, diet may prevent dementia and even slow its progress, especially in early stages. This has been headline News in Forbes and U. S. News World Report. It was developed in 2015 by a nutritional epidemiologist named Martha Claire Morris and her team. Geez, I don't even know any nutritional epidemiologists. But anyway, MIND stands for Mediterranean DASH Intervention for Neurodegenerative Delay. Whew, that was a mouthful. Let's try that again. MIND stands for Mediterranean DASH Intervention for Neurodegenerative Delay. That's a mouthful. Basically, what she did was combine two well-known diets, the Mediterranean diet and the DASH diet. If you listen to my podcast on hypertension, you know the DASH diet stands for Dietary Approaches to Stop Hypertension, and it focuses on lowering salt in the diet. I'll put a link to that in the show notes. The MIND diet is similar to Mediterranean with less emphasis on fish and fruit with the exception of berries. If you remember one thing today, remember berries. Now, let's go over the specific recommendations of the MIND diet. And don't worry about taking notes because I've put a downloadable printout in the show notes along with a smoothie recipe that helps you knock out some of these things all at once. But here's the weekly dose. Six servings of green leafy vegetables every week. You know, Popeye never had any cognitive decline. Uh, maybe that's a terrible example, but hopefully it helps you remember. Spinach, kale, arugula, collard greens. Swiss chard, turnip greens are rich in folate, lutein, vitamin E, beta carotene, and other nutrients that protect cognition, especially as people get older. You need at least one other serving of vegetables that aren't starchy, so not potatoes. Think more broccoli, squash, asparagus, beets, bell peppers, cabbage, carrots, eggplant, and okra. Also, five servings of nuts, or more, weekly, and I think just make it simple and eat a handful every day. Almonds, Brazil nuts, cashews, pecans, pistachios, or walnuts. Nuts are good for the brain. And, they're a rich source of vitamin E, B vitamins, healthy fats, as well as minerals such as magnesium, potassium, and calcium. Now, I mentioned before, berries are important. Eat at least two servings a week? But I say more. Put some blueberries or raspberries on your oatmeal or eat strawberries for dessert. Berries are great for making smoothies and you can drink all those antioxidants which are not only good for your brain but your body too. For Valentine's Day this year, I served Nice Cream. It's a recipe I got out of the How Not to Die cookbook. I'll put a link for that in the show notes too. You need a minimum of four servings a week of beans. I know that's a lot, but they're so, so good for you. Lots of protein in a great source of fiber too, so you feel full and there's such variety. You can incorporate beans in creative ways like chickpeas in hummus or pinto bean dip. White beans, make a good salad mixed with cucumbers and olive oil and vinagerette. Kidney beans go great in soups, and if you've never made lentils, look up some recipes. They're easy, versatile, and delicious. Black beans make a great meat substitute, and you can even make brownies with them. And don't knock it unless you've tried it. They're really yummy. I'll put a link in the show notes. When cooking, always use olive oil instead of canola, vegetable oil, or safflower oil. When it comes to whole grains, you need three servings a day. The other recommendations are for the week, but this one's daily and it's hard to eat whole grains because most breads and cereals are processed. So try quinoa, oatmeal, and brown rice. They're chocked full of vitamin B and vitamin E and a good source of fiber. I still think it's a challenge to get in three servings a day, but if you start your day with oatmeal, that works. You can add oatmeal to a smoothie by the way. At least one serving of fish each week is included on the MIND diet. Now these should be fish that are high in omega 3s. Typically those are your fattier type fishes like salmon and tuna. Chicken or turkey twice a week, and I hope it goes without saying that we're not talking about chicken nuggets and we are not talking about fried chicken. And originally they recommended one glass of red wine a day, but there's been some uncertainty about whether or not this is beneficial, and certainly limit it to one. Now, here's the what not to eat list. butter and margarine and gosh it kills me to even say that. You would not believe how much butter I like to cook with. Actually, I don't cook with it like I used to because the evidence is so good that diet can prevent dementia. I've cut back. The limit is however one tablespoon a day.  Now you may not be slathering it on your bread or toast, but think about sauces. And such as that. And here's a good substitute. If you want to smear something on a piece of bread, try a mushy avocado. It tastes delicious. And if butter was hard, the next one's even harder. Cheese. Ugh. Only one serving a week. Now, one thing I've done to help with this is swap it out for nutritional yeast. It has a cheesy taste and it's used in a lot of cheese free recipes to give it that flavor. Red meat on the MIND diet is recommended no more than three weekly servings. But we know it's not good for your blood pressure or heart and it increases the risk of cancer. So I would skip this one. Last on the limit this list is sweets and pastries. It says no more than four times a week, but personally I think that's generous. For me, I need to go pretty much all or none. Once I start with sweets, I want them more and more. So I'd say limit to a very small amount on very special occasions. And remember, you're going to have to define what is a special occasion. Do you think you could follow the MIND diet? How about a little more motivation? In one study of approximately a thousand older adults, there was a 53 percent lower risk of developing Alzheimer's in those who followed the MIND diet compared to those who didn't. 53 percent is impressive. The MIND diet has only been around for about 8 years, so there aren't as many studies on it as there are on the DASH and Mediterranean diets. But there was a really big study published in a British medical journal in March of 2023 that showed that the Mediterranean diet reduced the risk of developing dementia by 25%. And that's even in people who were genetically predisposed. And when I say big study, there were 60, 000 seniors in this one. That's powerful data. And there are other benefits to following either of these diets too, such as prevention of heart disease, diabetes and cancer as well as lower blood pressure and improved digestive health. If that's not convincing enough, then you should know that whole foods and those with high fiber also help you lose weight. Alright, maybe we can do without the cheese and butter, right? Now that we've talked about diet, let's move on to an equally important pillar of lifestyle medicine. Exercise. It is well known that physically active bodies have sharper minds. We need 30 to 60 minutes of activity per day, but any amount reduces your risk and it's dose dependent. A Harvard study showed that even light activity such as running errands or getting up and cleaning the house is a lot better than doing nothing. A lot better. According to an article published in the Journal of Neurology in 2022, The reduction of risk from just getting up off the couch is 21%. But aim for 150 minutes of moderate to high intensity exercise each week because that's associated with a 35 percent reduction. This means you're exercising hard enough that it's hard to talk without being breathless. But again, every little bit helps, so just get started. And do something you like. Involve your kids or grandkids because the earlier you start, the better. Okay, now that you're motivated to eat healthy and get more exercise, you need to look at your sleeping patterns. I covered restorative sleep in one of my earlier podcasts. I'll just put a link to that in the show notes. And what about stress? Does that affect our risk for dementia? Well, here's something particular when it comes to the risk. Recurrent negative thoughts. And that's a hard habit to break. So listen. If the news or the social media has you all riled up, then it's time to unplug.  Complaining is another attitude that becomes routine. And you know what else? It is contagious. Be sure you don't get together with your friends and complain. Practice gratitude instead. It's the polar opposite. And you can't complain and be grateful at the same time. And think of this as a mental exercise to build a healthy brain. You can work on some positive psychology if you want, but for me, I like to focus on the Bible verse that says, whatever is true, whatever is honorable, whatever is just, whatever is pure, whatever is lovely, whatever is commendable. If there is anything excellent or worthy of praise, think about these things. I don't know about you, but I think nature is lovely. So get outside and enjoy the trees, the flowers, the mountains, or lakes. It is literally good for your brain. You might think about social connection being important in the prevention of dementia, but studies show that people who have engaging relationships with family and friends are less likely to experience cognitive decline. One study showed that the type of people who talk to the checker at the grocery store have a lower incidence. You know the type, right? Yes, that would be me. I actually had a great conversation with an elderly lady who scanned my groceries. Her name was Barbie, and she walks her dog every day for exercise. Tell her I said hello next time you go to the store. It'll be good for both of you. Now we've talked about the do's. Eat the MIND, diet, exercise moderately 150 minutes a week. Manage your stress. Make sure you have good sleep hygiene. And nurture your relationships with others. Now let's talk about the don'ts. We know that the use of tobacco and tobacco products is bad for the heart and lungs, but what about the brain? Well, duh. It worsens hypertension and vascular disease, which clearly aren't good for you. The World Health Organization estimated that 14 percent of dementia cases worldwide would be prevented with smoking cessation. That's the good news. If you quit, your risk diminish too. Listen, I know it's hard. If you need help, I put a few resources in the show notes. And I also have a link to the podcast that covered that now, let's wrap up with the association between alcohol use and dementia. Heavy drinking can increase the risk of developing dementia or, alcohol related brain disease. When I was a kid, I was told that alcohol damages your brain. And it turns out that's true. Alcohol can damage memory and speed up disease in the blood vessels in the brain.  There is even a specific form of dementia associated with heavy alcohol use over a long period of time. It's called ARBD, alcohol related brain damage. There was a large study in 2022 of nearly 37, 000 middle aged and older adults with no major health problems. Those who consumed more than three units of alcohol per day had less white and gray matter in their brain. In fact, it made their brains look three and a half years older. What's a unit of alcohol? Well, it's half a pint of beer or a small glass of wine. So the most prudent thing to do to protect your brain is to abstain altogether or at least limit your alcohol to no more than one drink a day. You know, drink a smoothie instead. Cheers to your health. If there's one change you can make on the do list, it's eat more berries. If there's one change you can make on the don't list, eliminate ultra processed foods. And in the end, say the serenity prayer, God help me to accept the things that I cannot change. To change the things that I can change, and the wisdom to know the difference.  I also think it's important for us to address caregivers. I have an upcoming episode on that. But for now, remember, the MIND Diet, stay active, both mentally and physically, and be social, because a healthy brain looks great on you. The information contained in this podcast is for educational purposes only and is not considered to be a substitute for medical advice. You should continue to follow up with your physician or healthcare provider and take medication as prescribed. Though the information in this podcast is evidence based, new research may develop and recommendations may change.

In the next two episodes of Sapio with Buck Joffrey, we are going to talk about Alzheimer's disease. If you have never seen someone progress through the different stages of Alzheimer's disease, consider yourself lucky. This is a heartless disease that robs people of their most prized possession: their memories of their loved ones and of everything else about their lives. It also robs them of their ability to function in this world. Over the next 2 episodes of Sapio, you are going to learn what Alzheimer's disease is, what the risk factors are, the steps we can take to minimize our risk of getting Alzheimer's disease in the future, and even potential cures on the horizon. My expert guest for these discussions is my friend Dr. John Foley. Dr. Foley is a neurologist who is at the cutting edge of the clinical and scientific advances in the treatment of Alzheimer's disease and MS. Make sure to tune in to this show. I guarantee you that it's relevant to you or to someone you love. Show Notes: 00:02:49:20 What is dementia? 00:03:49:21 How to Make a Diagnosis of Alzheimer's Disease 00:05:46:19 The Story of Alois Alzheimer 00:07:22:06 What is Alzheimer's 00:10:22:14 Why do people get Alzheimer's? 00:13:05:15 The Risk Factors  00:23:14:09 What is sleep fragmentation and how does an understanding of it help with Alzheimer's? 00:29:25:03 The Genetics of Alzheimer's 00:35:41:20 How do hearing loss and hearing aid relate to Alzheimer's? Learn more about Dr. John Foley at cereprobio.com

Alois Alzheimer war ein fortschrittlicher Psychiater und Nervenarzt, der sich intensiv mit seinen Patienten befasste. Seine spätere Berühmtheit erlebte er nicht mehr.

Informativo de primera hora de la mañana, en el programa El Remate de La Diez Capital Radio. Hoy se cumplen 616 días del cruel ataque e invasión de Rusia a Ucrania. Hoy es viernes 3 de noviembre de 2023. Buenos días Ucrania, Gaza e Israel. Día Internacional de las Reservas de la Biosfera. La UNESCO proclamó el 3 de noviembre como Día Internacional de las Reservas de la Biósfera, con la finalidad de destacar la importancia de estos espacios naturales en la conservación de los ecosistemas y la biodiversidad, promoviendo la investigación, el desarrollo sostenible y la toma de decisiones sobre el cuidado del medio ambiente. Las Reservas de la Biósfera son aquellos espacios del planeta que poseen recursos naturales que representan la diversidad de hábitats, albergando una amplia variedad de ecosistemas y de biodiversidad: bosques tropicales húmedos, tundras, bosques templados, desiertos árticos, bosques boreales, bosques pluviales subtropicales, entre otros espacios. Son reconocidos internacionalmente, manteniendo su soberanía en cada país. Poseen un invaluable interés científico, biológico, ecológico y cultural, promoviendo la investigación, educación y el intercambio de experiencias. Asimismo, el mantenimiento de estos espacios naturales contribuye al crecimiento de las economías locales. 1820: Cuenca se independiza violentamente de España. Tal día como hoy, un 3 de Noviembre del año 1883, Antonio Gaudí recibió el encargo de continuar con la construcción del Templo Expiatorio de la Sagrada Familia de Barcelona. La obra maestra del arquitecto modernista todavía se encuentra en construcción. No obstante, esto no impide que sea uno de los monumentos más visitados de España, junto al Museo del Prado y la Alhambra de Granada. 1906.- El psiquiatra alemán Alois Alzheimer presenta a la comunidad médica "un proceso patológico grave de la corteza cerebral", considerado la primera descripción de la demencia tipo alzheimer. 1911: La marca automotriz Chevrolet ingresa en el mercado, tomándose esta fecha como la de su fundación. 1943.- El Gobierno español ordena la repatriación de la División Azul, una unidad de voluntarios españoles formada para luchar contra la Unión Soviética durante la Segunda Guerra Mundial. Mucho tiempo después, en 1957, la Unión Soviética puso en órbita el Sputnik 2, que llevó a bordo a la famosa perra Laika. Esta se convirtió en el primer ser vivo terrestre en orbitar la Tierra. Lamentablemente, falleció cinco horas después del despegue, a causa del estrés y el sobrecalentamiento de la cápsula. 1958.- Se inaugura en París la sede de la ONU para la Educación, la Ciencia y la Cultura (UNESCO). 1998.- Se inaugura en Estrasburgo (Francia) el Tribunal Europeo de Derechos Humanos (TEDH). 1999: El juez español Baltasar Garzón procesa a 98 militares argentinos por las desapariciones ocurridas durante el Régimen Militar de Chile. 2000: En el espacio comienza a funcionar la Estación Espacial Internacional. 2010.- En Estados Unidos, el estudio de Hollywood Metro Goldwyn Mayer (MGM) se declara oficialmente en bancarrota. Patrocinio del santo de cada día por gentileza de la Casa de las Imágenes, en la calle Obispo Perez Cáceres, 17 en Candelaria. Santoral para hoy 3 de noviembre: santos Martín de Porres, Pedro Armengol y Huberto. Santa Silvia. Amnistía Internacional y Human Rights Watch acusan a Israel de utilizar munición con fósforo blanco. Putin saca a Rusia del tratado que prohíbe los ensayos nucleares. Aragonès, tras el pacto de ERC y PSOE sobre la amnistía: "Es hora de avanzar hacia el referéndum". PSOE y ERC pactan un relato acrítico del 'procés' y el perdón de 15.000 millones de deuda a Cataluña El ministro de la Presidencia y el líder de Esquerra sellan su acuerdo, que introduce un factor de presión sobre Junts. La no bajada del IGIC enfrenta a Gobierno y oposición con acusaciones de engaño en el Parlamento canario. No solo no se ha reducido este impuesto sino que se ha subido para determinados productos, lo que ha alimentado las críticas de PSOE y NC, mientras el Ejecutivo se escuda en la “incertidumbre institucional”. Clases 'online' y jornadas más cortas en el protocolo educativo ante las olas de calor. La Consejería tiene listo el borrador del documento que pasará a Sanidad y a Seguridad y Emergencias. También trabaja en un «libro digital» para conocer el estado de los centros Q. La marcha del turismo extranjero hasta septiembre hace prever que Canarias pueda superar las llegadas de 2022 e incluso 2019. Las Islas deben recibir más de 3,3 millones de extranjeros en el último trimestre, temporada alta, para superar los umbrales de esos años; con la mayor llegada de peninsulares, es posible mejorar el dato global de 2019, año prepandémico. Ni 'brexit' ni inflación: un cuarto de millón de plazas más que el invierno pasado para el turismo británico. Las aerolíneas ofertan 2,8 millones de asientos para las vacaciones en Canarias de los ciudadanos de Reino Unido. Octubre marca el récord de llegadas de inmigrantes a Canarias: 14.976 personas en sólo un mes 30.705 han llegado en lo que va de año, cerca de superar los de la 'crisis de los cayucos en 2006'. El máximo histórico registrado en 2006, cuando arribaron 31.678 personas en todo el año. La Audiencia Nacional anula el cese del coronel de Santa Cruz de Tenerife implicado en el caso Cuarteles. Considera que la decisión del Ministerio del Interior no está “suficientemente motivada”. Un día como hoy pero en 1987.- El cantautor británico George Michael publica "Faith" su primer álbum de estudio tras separarse del dúo Wham que formó hasta 1986 con Andrew Ridgeley.

Programa de actualidad con información, formación y entretenimiento conectando directamente con los oyentes en La Diez Capital radio. Dirigido y presentado por Miguel Ángel González Suárez. www.ladiez.es - Informativo de primera hora de la mañana, en el programa El Remate de La Diez Capital Radio. Hoy se cumplen 616 días del cruel ataque e invasión de Rusia a Ucrania. Hoy es viernes 3 de noviembre de 2023. Buenos días Ucrania, Gaza e Israel. Día Internacional de las Reservas de la Biosfera. La UNESCO proclamó el 3 de noviembre como Día Internacional de las Reservas de la Biósfera, con la finalidad de destacar la importancia de estos espacios naturales en la conservación de los ecosistemas y la biodiversidad, promoviendo la investigación, el desarrollo sostenible y la toma de decisiones sobre el cuidado del medio ambiente. Las Reservas de la Biósfera son aquellos espacios del planeta que poseen recursos naturales que representan la diversidad de hábitats, albergando una amplia variedad de ecosistemas y de biodiversidad: bosques tropicales húmedos, tundras, bosques templados, desiertos árticos, bosques boreales, bosques pluviales subtropicales, entre otros espacios. Son reconocidos internacionalmente, manteniendo su soberanía en cada país. Poseen un invaluable interés científico, biológico, ecológico y cultural, promoviendo la investigación, educación y el intercambio de experiencias. Asimismo, el mantenimiento de estos espacios naturales contribuye al crecimiento de las economías locales. 1820: Cuenca se independiza violentamente de España. Tal día como hoy, un 3 de Noviembre del año 1883, Antonio Gaudí recibió el encargo de continuar con la construcción del Templo Expiatorio de la Sagrada Familia de Barcelona. La obra maestra del arquitecto modernista todavía se encuentra en construcción. No obstante, esto no impide que sea uno de los monumentos más visitados de España, junto al Museo del Prado y la Alhambra de Granada. 1906.- El psiquiatra alemán Alois Alzheimer presenta a la comunidad médica "un proceso patológico grave de la corteza cerebral", considerado la primera descripción de la demencia tipo alzheimer. 1911: La marca automotriz Chevrolet ingresa en el mercado, tomándose esta fecha como la de su fundación. 1943.- El Gobierno español ordena la repatriación de la División Azul, una unidad de voluntarios españoles formada para luchar contra la Unión Soviética durante la Segunda Guerra Mundial. Mucho tiempo después, en 1957, la Unión Soviética puso en órbita el Sputnik 2, que llevó a bordo a la famosa perra Laika. Esta se convirtió en el primer ser vivo terrestre en orbitar la Tierra. Lamentablemente, falleció cinco horas después del despegue, a causa del estrés y el sobrecalentamiento de la cápsula. 1958.- Se inaugura en París la sede de la ONU para la Educación, la Ciencia y la Cultura (UNESCO). 1998.- Se inaugura en Estrasburgo (Francia) el Tribunal Europeo de Derechos Humanos (TEDH). 1999: El juez español Baltasar Garzón procesa a 98 militares argentinos por las desapariciones ocurridas durante el Régimen Militar de Chile. 2000: En el espacio comienza a funcionar la Estación Espacial Internacional. 2010.- En Estados Unidos, el estudio de Hollywood Metro Goldwyn Mayer (MGM) se declara oficialmente en bancarrota. Patrocinio del santo de cada día por gentileza de la Casa de las Imágenes, en la calle Obispo Perez Cáceres, 17 en Candelaria. Santoral para hoy 3 de noviembre: santos Martín de Porres, Pedro Armengol y Huberto. Santa Silvia. Amnistía Internacional y Human Rights Watch acusan a Israel de utilizar munición con fósforo blanco. Putin saca a Rusia del tratado que prohíbe los ensayos nucleares. Aragonès, tras el pacto de ERC y PSOE sobre la amnistía: "Es hora de avanzar hacia el referéndum". PSOE y ERC pactan un relato acrítico del 'procés' y el perdón de 15.000 millones de deuda a Cataluña El ministro de la Presidencia y el líder de Esquerra sellan su acuerdo, que introduce un factor de presión sobre Junts. La no bajada del IGIC enfrenta a Gobierno y oposición con acusaciones de engaño en el Parlamento canario. No solo no se ha reducido este impuesto sino que se ha subido para determinados productos, lo que ha alimentado las críticas de PSOE y NC, mientras el Ejecutivo se escuda en la “incertidumbre institucional”. Clases 'online' y jornadas más cortas en el protocolo educativo ante las olas de calor. La Consejería tiene listo el borrador del documento que pasará a Sanidad y a Seguridad y Emergencias. También trabaja en un «libro digital» para conocer el estado de los centros Q. La marcha del turismo extranjero hasta septiembre hace prever que Canarias pueda superar las llegadas de 2022 e incluso 2019. Las Islas deben recibir más de 3,3 millones de extranjeros en el último trimestre, temporada alta, para superar los umbrales de esos años; con la mayor llegada de peninsulares, es posible mejorar el dato global de 2019, año prepandémico. Ni 'brexit' ni inflación: un cuarto de millón de plazas más que el invierno pasado para el turismo británico. Las aerolíneas ofertan 2,8 millones de asientos para las vacaciones en Canarias de los ciudadanos de Reino Unido. Octubre marca el récord de llegadas de inmigrantes a Canarias: 14.976 personas en sólo un mes 30.705 han llegado en lo que va de año, cerca de superar los de la 'crisis de los cayucos en 2006'. El máximo histórico registrado en 2006, cuando arribaron 31.678 personas en todo el año. La Audiencia Nacional anula el cese del coronel de Santa Cruz de Tenerife implicado en el caso Cuarteles. Considera que la decisión del Ministerio del Interior no está “suficientemente motivada”. Un día como hoy pero en 1987.- El cantautor británico George Michael publica "Faith" su primer álbum de estudio tras separarse del dúo Wham que formó hasta 1986 con Andrew Ridgeley. - Sección de actualidad con mucho sentido de Humor inteligente en el programa El Remate de La Diez Capital radio con el periodista socarrón y palmero, José Juan Pérez Capote, El Nº 1. - Sección de actualidad informativa con Pepe Rodríguez, director de Capital radio Gran Canaria. La amnistía, CC apoyara a Pedro Sánchez? Universidades, regata y UD. Las Palmas. - Hoy en nuestro programa el Remate de La Diez Capital radio entrevistamos a Sergio David Hernández, propietario de la empresa Bonadea y Vicepresidente de la asociación de conservación de cetáceos de Tenerife. - Hoy en nuestro programa el Remate de La Diez Capital radio entrevistamos a Javier Almunia, Director de Loro Parque Fundación. Canarias y la Macaronesia son un paraíso para los mamíferos marinos gracias a su estratégica situación geográfica. Prueba de ello es que somos un punto caliente de biodiversidad de cetáceos a nivel mundial, albergando el 85% de las especies de ballenas y delfines presentes en todo el océano Atlántico Norte. Loro Parque Fundación, como uno de los líderes en la preservación de la flora y la fauna de las Islas, promueve la creación de un Área Marina Protegida para la protección de la biodiversidad marina de la Macaronesia, en un esfuerzo internacional para el uso sostenible de los recursos de los océanos. El Área Marina Protegida brinda refugio a los animales de la zona ante las amenazas a las que se enfrentan, en gran parte, provocadas por la acción humana. Asimismo, estos lugares pueden servir como fuente de conocimientos para la investigación. Un proyecto que lleva más de 40 años de trayectoria y que ha recibido el apoyo institucional del Parlamento de Canarias, un hito trascendental para la puesta en marcha de esta iniciativa, que busca proteger a los cetáceos de los múltiples peligros a los que se enfrentan en las aguas de la región. - Sección en La Diez Capital radio con la periodista y corresponsal de la televisión Brasileña en España, Cleo Costa. Hoy conocemos más a fondo el municipio de Talavera de la Reina.

Eponyms honor people who discover diseases, treatments, and procedures. You may be familiar with ones like Alzheimer's disease, named after Alois Alzheimer, or Hodgkin's lymphoma, discovered by Thomas Hodgkin. However, our experts explain how eponyms can go awry and place honor on criminals or even the wrong person. Learn More: https://radiohealthjournal.org/honoring-nazi-doctors-and-criminals-the-dark-side-of-medical-eponyms Learn more about your ad choices. Visit podcastchoices.com/adchoices

En 1901 atendió a Auguste Deter, quien es considerada la primera paciente con Alzheimer del mundo. El médico encontró que en su cerebro había acumulación de placas y neurofilamentos, lo que explicaba su enfermedad.

El 14 de junio de 1864 nace en un pueblo alemán llamado Marktbreit, el neurólogo Alois Alzheimer, quien descubriría año después la neuropatología que, a día de hoy, lleva su apellido.

Dementia is often designated the “plague” of the twenty-first century. What does a cultural history of dementia reveal about commonly circulating ideas relating to the brain, personhood, embodiment, and normal/abnormal? What difference do “labels” make – “melancholy”, “lunacy”, “dotage”, and “senility”, for example?The lecture uses the historical development of the science of geriatrics to reflect on the experience of ageing and claims about the modern self.A lecture by Joanna Bourke recorded on 11 May 2023 at Barnard's Inn Hall, London.The transcript and downloadable versions of the lecture are available from the Gresham College website: https://www.gresham.ac.uk/watch-now/dementia-historyGresham College has offered free public lectures for over 400 years, thanks to the generosity of our supporters. There are currently over 2,500 lectures free to access. We believe that everyone should have the opportunity to learn from some of the greatest minds. To support Gresham's mission, please consider making a donation: https://gresham.ac.uk/support/Website:  https://gresham.ac.ukTwitter:  https://twitter.com/greshamcollegeFacebook: https://facebook.com/greshamcollegeInstagram: https://instagram.com/greshamcollegeSupport the show

O Alzheimer, doença neurodegenerativa que compromete as funções cognitivas: memória, orientação, atenção e linguagem, é o tema do Podcast Acessando Lucília desta terça-feira, 07/02. Fevereiro é o mês roxo e laranja na paleta de cores da conscientização e do combate de algumas doenças. A cor roxa remete ao lúpus, à fibromialgia e ao Alzheimer. O laranja à leucemia. Alzheimer é a causa mais comum de demência. Em estágio mais avançado causa a perda de habilidades intelectuais e sociais. Segundo dados da Associação Brasileira de Alzheimer - Abraz, no Brasil há cerca de 1,2 milhão de casos, a maior parte deles ainda sem diagnóstico. No mundo são cerca de 35,6 milhões de pessoas com a doença, cujo nome oficial refere-se ao médico Alois Alzheimer, o primeiro a descrevê-la, em 1906. Nossas convidadas para esta conversa são: Talita Pessoa dos Reis, médica formada pela Universidade Federal do Rio de Janeiro, especialista em geriatria pela Sociedade Brasileira de Geriatria e Gerontologia / Associação Brasileira de Medicina-SBGG /AMB, e médica assistente do Núcleo de Atendimento ao Idoso na Marinha, no Rio de Janeiro; e Luciana Franco, graduada e doutorada em psicologia pela Universidade Federal Fluminense, especialista em psicanálise e saúde mental pela Universidade do Estado do Rio de Janeiro, psicóloga clínica e também uma admiradora das palavras e das histórias. O bate-papo será transmitido ao vivo, às 18h, na página da Web Rádio Censura Livre, no Youtube (youtube.com/c/Censuralivre), no Facebook facebook.com/webradiocensuralivre/), site (www.clwebradio.com) e nos aplicativos: RadiosNet (http://l.radios.com.br/r/100204), no App exclusivo da emissora (http://webapp.hoost.com.br/clwebrad/) e agora também no Twitter@wrcensuralivre. #audiodescrição Card de fundo preto com detalhes em rosa, verde e letras brancas. À esquerda, dentro de círculos verde e rosa, uma mulher branca de cabelo castanho claro sorridente e com uma camiseta preta: Luciana Franco. Ao centro, a figura de um microfone estilizado e ao centro: Podcast Acessando Lucília À direita, dentro de círculos verde e rosa, a foto da titular do Podcast: uma mulher branca, de cabelo castanho escuro e blusa branca, à frente de um microfone com detalhe vermelho À esquerda, dentro de círculos verde e rosa, uma mulher branca de cabelo castanho escuro, óculos e blusa preta: Talita Pessoa Ao centro: Fevereiro Roxo Para o Combate ao Alzheimer 07/02 – 18h – Ao Vivo Na parte inferior à direita, o logo da Web Rádio Censura. E ao lado: http://facebook.com/webradiocensuralivre/ http://youtube.com/c/CensuraLivre https://twitter.com/wrcensuralivre Você pode ouvir a Web Rádio Censura Livre no aplicativo RadiosNet (http://l.radios.com.br/r/100204), no App exclusivo da emissora (http://webapp.hoost.com.br/clwebrad/) ou no site www.clwebradio.com @radiocensuralivre Fale conosco: WhatsApp: (21) 9 6553-8908 Ouça o podcast do programa em: Anchor FM, Spotify e Google Podcast. #FevereiroRoxo #ParaoCombateaoAlzheimer #AcessandoLucília #WebRádioCensuraLivre

For thousands of years, humans have been aging. And as our technology has progressed, so has our understanding of aging. We now know that while chronological aging is inevitable, biological aging is not. That's why it's so important to understand the biology of aging. We can reduce our risk factors for disease and improve our quality of life by making conscious choices about how we live our lives.When you hear that the baby boomer generation is getting older and people are living longer than ever before, what does that mean for us? Well, the definition of "aging successfully" is up for debate. Some people think that baby boomers have taken advantage of the system and should retire earlier.Others argue that we need to find a way to financially support older adults who are unable to work. There are also concerns about whether or not the healthcare system can handle an aging population. Many baby boomers are choosing to stay active and healthy well into their golden years. So, it's important to remember that each person's experience with aging is unique. We should all be prepared for the challenges and opportunities that come with growing old.Will baby boomers be the last generation to experience successful aging? Or will millennials and Generation X continue to enjoy good health into their golden years? Only time will tell.But one thing is for sure: the science of aging is constantly evolving, and we're only getting better at fighting the effects of age-related disease.No matter what the future holds, we should all strive to age gracefully and with dignity.----------Joining me today is DR. GIULIO MARIA PASINETTI, MD, Ph.D. He is a world-renowned expert on aging and Alzheimer's disease. He has dedicated his life to understanding the root causes of brain disorders. By developing model systems of brain disorders, he has been able to clarify their underlying mechanisms and develop preventative and therapeutic approaches for neurological disorders. This research has earned him a strong record of successful and productive endeavors.He is currently the Saunders Family Chair and Professor of Neurology at The Icahn School of Medicine at Mount Sinai, as well as the Director of the Basic and Biomedical Research and Training Program of the James J. Peters Veterans Affairs Medical Center.You can find Dr. Pasinetti on these platforms:LinkedIn: https://www.linkedin.com/in/giulio-maria-pasinetti-md-phd-943b1b39/Twitter: https://twitter.com/IcahnCMIN

Pacientů s Alzheimerovou chorobou u nás i ve světě stále přibývá. Přitom ve chvíli, kdy německý lékař Alois Alzheimer na počátku minulého století nemoc popsal, byla považována za vzácnou. Dnes žije v Evropě devět milionů lidí s tímto typem demence.Všechny díly podcastu Zdravíčko můžete pohodlně poslouchat v mobilní aplikaci mujRozhlas pro Android a iOS nebo na webu mujRozhlas.cz.

Aloysius Alois Alzheimer​ fue un psiquiatra y neurólogo alemán que identificó por primera vez los síntomas de lo que luego se conocería como enfermedad de Alzheimer.​ Los observó en una paciente que vio en 1901, y publicó en 1907 los descubrimientos que hizo al examinar post mortem su cerebro.​

On episode 129, we welcome Dr. Sara Manning Peskin to discuss her new book ‘A Molecule Away from Madness'; the fascinating stories of the scientists who discovered the molecules that cause neurological diseases and their cures, including Alois Alzheimer (who discovered the tangles and plaques of Alzheimer's) and Joseph Goldberger (who helped discover the cause of pellagra by ingesting pills of poop with others in “filth parties”; how those scientists found the courage and resolve to fight for their discoveries when their colleagues mocked and ignored them; how diets, genes, antibodies, and proteins create neurological illnesses; Abraham Lincoln's drastic personality change from mercury-laced prescription pills; the difference between Alzheimer's and Dementia, and pseudo-dementia in the chronically mentally ill; how our tools have helped us distinguish the subtle differences of various disorders and their implications for treatment; the profound personal stories of individuals struggling with those ailments; and why the behavior related to neurological illnesses is often excused while we tend to lack empathy for those struggling with mental illness. Sara Manning Peskin, MD, MS is an assistant professor of clinical neurology at the University of Pennsylvania. She is part of both the Penn Memory Center and the Penn Frontotemporal Dementia Center. Her writing has appeared in the New York Times, Boston Globe Magazine, and the Philadelphia Inquirer. Her new book, out now, is called A Molecule Away from Madness. Sarah Manning Peskin | ► Website | https://saramanningpeskin.com/ ► A Molecule Away from Madness |  https://amzn.to/3kvTMaY Where you can find us: | Seize The Moment Podcast | ► Facebook | https://www.facebook.com/SeizeTheMoment ► Twitter | https://twitter.com/seize_podcast  ► Instagram | https://www.instagram.com/seizethemoment

Dr. Alois Alzheimer was the man behind the discovery of Alzheimer's, a neurodegenerative disease that wreaks havoc on seniors, and some younger than that. This condition, discovered by the tangles in the brain along with other symptoms, was a remarkable discovery at the time.   However, Dr. Alzheimer was not always taken seriously with his research, and this marked discovery actually was dismissed by the other psychiatrists at the facility he worked at.   So how did it come to be? How did this discovery shape the world of geriatric medicine, and how did it pave the way for discovering the makeup of Alzheimer's and how does that help us better understand this today?   This episode will take a deeper look into the life of the man behind it all, the psychiatrist that discovered this condition, and at the end of this episode, you'll learn everything you need to know about this man's life, and how his discovery came to be.

Connaissez-vous les sœurs Tatin, Alois Alzheimer et Eugène-René Poubelle (photo) ? Vous les connaissez, leurs noms étant entrés dans le vocabulaire courant, sans vraiment les connaître. Cette semaine, je m'intéresse à ces gens dont le nom survit à travers des objets, des maladies et des plats.

Today's Quick Tips episode is congruent with our series on the seven stages of Alzheimer's disease. We have been talking a lot about Alzheimer's lately, but it is an important topic that we could never exhaust. Today's Quick Tips episode is about recognizing Alzheimer's disease. First, we'll discuss what Alzheimer's is. Then, we'll move on to some of the common signs and symptoms of Alzheimer's and what to do when you notice signs. Finally, we'll talk about resources, tips, and tools to help families dealing with Alzheimer's. Now let's move on to the rest of the show.   The National Institute on Aging explains that Alzheimer's disease is a brain disorder that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks. The disease is named after Dr. Alois Alzheimer. In 1906, Dr. Alzheimer noticed changes in the brain tissue of a woman who had died of an unusual mental illness. Her symptoms included memory loss, language problems, and unpredictable behavior. After she died, he examined her brain and found many abnormal clumps, what we now call amyloid plaques, and tangled bundles of fibers, what we now call neurofibrillary, or tau, tangles.   Alzheimer's disease affects more than 6 million Americans over 65. This number is not including those under 65, usually in their thirties or forties, diagnosed with early-onset Alzheimer's. Currently, the biggest known risk factor for Alzheimer's disease is age. As our population continues to rise, so will the number of Alzheimer's cases.   According to the Alzheimer's Association, the most common early symptom of Alzheimer's is difficulty remembering newly learned information. The NHS, the UK's biggest health website, lists some of the early symptoms of Alzheimer's as forgetting about recent conversations or events, misplacing items, forgetting the names of places and objects, having trouble thinking of the right word, asking questions repetitively, showing poor judgement or finding it harder to make decisions, and becoming less flexible and more hesitant to try new things.   If you are noticing symptoms in yourself or in a loved one, it's a good idea to start a journal or at least write down a list of symptoms when they appear so that you can have a log to take with you to your doctor. The next thing, and possibly the first thing you should do, is schedule an appointment with your doctor. A physician will be able to determine if you have Alzheimer's or if there are any other medical problems going on.   Your risk for developing Alzheimer's increases with a family history of Alzheimer's. If you have family members that have had Alzheimer's, make sure that your doctor is aware. Your doctor may want to do some testing to see if you have any genetic markers for the disease or to test for Alzheimer's. If you have the genetic markers for Alzheimer's, that doesn't mean that you will develop Alzheimer's, but that you have the chance of developing Alzheimer's.   There is no way to actually prevent Alzheimer's, but there are some ways to lower your risk of developing Alzheimer's. Eating a healthy diet and exercising your body and mind may help lower your risk. According to the Bright Focus Foundation, researchers are trying to understand if how we eat and what types of food we eat will lower your risk of developing Alzheimer's. Eating a diet high in whole grains, fruits, vegetables, and fish, and low in sugar and fat, such as the Mediterranean Diet, can reduce the incidence of many chronic diseases such as heart disease and Type 2 diabetes. Scientists are currently studying if eating healthy can reduce your risk of developing Alzheimer's and you may find that eating well increases your greater overall health.   The Bright Focus Foundation also says that physical exercise is an important part of a healthy lifestyle, and some studies suggest that it can improve cognitive agility. For an Alzheimer's patient, exercise may also help maintain muscle strength, decrease frailty, and elevate mood. Some research suggests that “exercising our brain,” through activities like reading, learning a musical instrument, or playing chess, can help protect people from cognitive decline later in life, which is what people with Alzheimer's experience.   The last thing Bright Focus Foundation recommends to lower your risk is to decrease your risk of head traumas. We are learning from people with battlefield or sports injuries that past traumatic head injury may be associated with Alzheimer's. Your risk increases if the injury involved you losing consciousness, or if you've had multiple head injuries from playing contact sports. This discovery is fueling public health efforts to improve the protective quality of helmets, and reduce the rates of head injuries, in certain sports.   If you or your loved one has Alzheimer's and you or your family are wondering how to support a loved one with Alzheimer's, the Alzheimer's Association is a good place to start. First, they recommend that you educate yourself about Alzheimer's disease and learn about its signs and symptoms and how you should talk to a loved one with Alzheimer's. Next, they say you should stay in touch. A card, a call, or a visit means a lot and shows you care. The person diagnosed with Alzheimer's isn't the only one dealing with a new stressful situation. Their friends and family are also adjusting to this new diagnosis and could use all the support they can get, as well.   Then, they say it's important to be patient. Adjusting to an Alzheimer's diagnosis is an ongoing process and each person reacts differently. If you can, offer a shoulder to lean on. The disease can create stress for the entire family. Simply offering your support and friendship is helpful.   You should also try to engage the person with dementia in conversation. It's important to involve the person in conversation even when his or her ability to participate becomes more limited. They may be feeling isolated from others during this time and you taking extra care to include them will make them feel special and cared for.   When you are available, offer to help the family with their to-do list. Prepare a meal, run an errand, or provide a ride. You should also try to engage family members in activities. Invite them to take a walk or participate in other activities. They may not take time for themselves after a loved one has been diagnosed with Alzheimer's. Similarly, offer family members a reprieve. Spend time with the person living with dementia so family members can go out alone or visit with friends. Your help can enable the family members and the person with Alzheimer's to all participate in their normal lives, which they might not be able to do without support from others.   When you're supporting someone with Alzheimer's and their family, it's important to be flexible. Don't get frustrated if your offer for support is not accepted immediately. The family may need time to assess its needs. When supporting those affected by Alzheimer's, the Alzheimer's Association also says that you should support the Alzheimer's cause. Supporting Alzheimer's, either financially or with your time, helps your loved ones with Alzheimer's, too. Knowing that other people in their community care about their situation can help them feel connected and cared for during a time when they are most likely feeling uncertain with their position in life.   If you are interested in learning more ways you can support someone with Alzheimer's or their loved ones, visit our show notes for resources.   We want to say thank you for joining us here at All Home Care Matters, All Home Care Matters is here for you and to help families as they navigate these long-term care issues. Please visit us at allhomecarematters.com there is a private secure fillable form there where you can give us feedback, show ideas, or if you have questions. Every form is read and responded to. If you know someone who could benefit from this episode please make sure to share it with them.   Remember, you can listen to the show on any of your favorite podcast streaming platforms and watch the show on our YouTube channel and make sure to hit that subscribe button, so you'll never miss an episode. We look forward to seeing you next time on All Home Care Matters, thank you.     Sources:   https://www.nia.nih.gov/health/what-alzheimers-disease   https://www.brightfocus.org/alzheimers/prevention-and-risk-factors   https://www.alz.org/alzheimers-dementia/what-is-alzheimers   https://www.brightfocus.org/alzheimers/prevention-and-risk-factors   https://www.alz.org/blog/alz/october-2019/10_ways_to_help_a_family_living_with_alzheimer_s                

Alzheimerovu chorobu, tedy vážné onemocnění projevující se ztrátou nervových buněk, poprvé popsal v roce 1906 německý lékař Alois Alzheimer. V Česku je tato nemoc diagnostikována 160 tisícům pacientů. A netýká se pouze lidí v seniorském věku.

Leta 1907 je Alois Alzheimer opisal bolezen pri 51-letni ženski, ki se ni znašla v svojem lastnem stanovanju, imela je spominske motnje in je bila sumničava. Alzheimerjeva bolezen je najpogostejši vzrok za demenco, napredujočo možgansko bolezen, ki prizadene predvsem starejše ljudi in je vse pogostejša. Bolezen še ni ozdravljiva, lahko pa lajšamo nekatere njene posledice. V ponedeljkovem svetovalnem servisu bo na vaša vprašanja odgovarjal prof. dr. Zvezdan Pirtošek, dr. med., specialist nevrolog s Kliničnega oddelka za bolezni živčevja na Nevrološki kliniki, predstojnik Katedre za nevrologijo na Medicinski fakulteti.

"Irrenarzt mit dem Mikroskop" wurde er genannt. Sein Vortrag über seine Patientin Auguste D. interessierte 1908 fast keinen. Erst nach seinem Tod wird die von ihm entdeckte Krankheit offiziell anerkannt. (BR 2018)

por luciano potter, magrolima e daniel scola. a vida é dura, mas já foi mais. e as dores que o mau funcionamento cerebral podem causar. este programa também se encontra em vídeo no youtube.

Contributions to the field of mental health by Black practitioners have been long overlooked. In this week's Financial Fridays episode, you'll learn more about Dr. Solomon Carter Fuller, one of the first known Black psychiatrists. Solomon Fuller’s major contribution was to the growing clinical knowledge of Alzheimer’s disease. In 1903, he was one of the five students chosen by Alois Alzheimer to do research at the Royal Psychiatric Hospital at the University of Munich in Germany. While practicing at Westborough State Mental Hospital in Westborough, Massachusetts, Dr. Fuller performed ground-breaking research on the physical changes to the brains of Alzheimer's patients. When you watch a movie or TV show, do you imagine yourself in the shoes of the lead character? How often does the actor portraying that character share some or all of your identity traits? In this week's Unplugged segment, Coach Colette shares another personal anecdote about her A-HA moment while watching Lupin on Netflix. She also discusses the emotional tax shouldered by women of color and how this burden impacts all facets of their health and wellbeing. If you enjoyed this episode, why not share it on Instagram and tag @coach_colette! She’ll be sure to share your comments and big takeaways on her Instagram Stories. Or, tweet your thoughts to @Coach_Colette. If you'd like to ask a question or make a topic suggestion, send us a message here. While you’re at it, we’d appreciate a rating on iTunes, Spotify, or wherever you listen. Or if you’d simply tell a friend about the show, that would be great too! Thanks for listening. --- Send in a voice message: https://anchor.fm/coach-colette/message Support this podcast: https://anchor.fm/coach-colette/support

In 1901, a 51-year-old woman named Auguste Deter shuffled into a German asylum. She had forgotten nearly everything about her life: where she lived, her husband's name, and how old she was. She was put into the care of revolutionary psychiatrist Alois Alzheimer.

Alois Alzheimer war der erste, der die heute nach ihm benannte Alzheimer Demenz im Detail beschrieb. Eine Patientin war in relativ jungem Alter verwirrt in seine Obhut gegeben worden und er zeichnete nicht nur ihre Symptome auf sondern analysierte auch nach ihrem Tod die Veränderungen in ihrem Gehirn...

Les rencontres de Catherine Schwaab qui reçoit Bruno Dubois, Professeur de Neurologie à l'Université Pierre et Marie Curie, Directeur de l'Institut de la Mémoire et de la Maladie d'Alzheimer à la Pitié-Salpêtrière à Paris. À propos du livre : «Alzheimer: La vérité sur la maladie du siècle» paru aux éditions Grasset  C’est l’une des maladies les plus craintes par les Français, mais aussi l’une de celles que le public connait le moins. C’est le grand mal du siècle, appelé à devenir dans les prochaines années la première préoccupation de santé de nos sociétés, mais un mal que la Recherche et la médecine ne savent pas encore soigner. Pourtant, à terme, il est probable que chacun connaîtra, dans son entourage, un proche atteint de la maladie d’Alzheimer. Les chiffres sont connus : 47 millions de cas de démence dans le monde, plus de 800 000 patients en France, 140 000 nouveaux cas chaque année, avec la perspective de voir ces chiffres doubler d'ici l'an 2030. Près de 20 % des sujets âgés de plus 80 ans en sont atteints. Les syndromes aussi : troubles de la mémoire, perte d’autonomie, démence, apathie progressive. Mais qu’est-ce, précisément, que cette maladie qui nous vole ce que nous avons de plus précieux, nos souvenirs et notre identité ? Qu’est-ce qui, dans le cerveau, dysfonctionne ? Comment la diagnostique-t-on ? Oublier le nom d’untel ou un mot doit-il suffire à nous alarmer ? Et comment la soigne-t-on ? Où en est la recherche ? Un médicament pourrait-il un jour être trouvé ou faut-il nous résoudre à voir de plus en plus d’hommes et de femmes sombrer dans l’oubli ? Quel sera alors le rôle de l’Etat ? Pour répondre à ces questions, et pour la première fois, le spécialiste de la maladie d’Alzheimer, le neurologue Bruno Dubois prend la parole et nous dit tout. Ce qu’est la maladie (I) : comment elle affecte les patients, l’entourage et la société. Comment on la prend en charge, ce que la société en sait. Son histoire (II) : du premier cas diagnostiqué par Alois Alzheimer aux différents plans présidentiels en passant par les aventures médicales et scientifiques qui ont permis de mieux la cerner. Ce que nous pouvons espérer (III). Le suivre dans cette épopée scientifique et ce cours magistral, c’est partager l’expérience d’un neurologue chevronné qui a contribué à définir la maladie pour mieux la vaincre ; comment il a dû se battre pour la faire reconnaitre comme une maladie spécifique, pour obtenir certains appareils nécessaires au diagnostic, pour informer aussi, et aller contre les inepties relayées par les médias, d’après lesquelles un carré de chocolat pourrait prévenir ou même guérir ; comment il se bat aujourd’hui pour lever des fonds. Dans cet ouvrage passionnant, il met enfin des mots sur cette maladie redoutée et livre sans fard toute la vérité sur Alzheimer. Un document choc, nécessaire. Bruno Dubois est Professeur de Neurologie à Sorbonne Université, président de la société française de neurologie et chef du service des Maladies Cognitives et Comportementale à l’Hôpital de la Salpêtrière. Il est aussi Directeur de l’équipe Inserm «Cognition, Neuro-imagerie et Maladies du cerveau» de l’Institut du Cerveau et de la Moelle Epinière, coordinateur du CMRR de la région Ile-de-France et du Centre National de Référence des Démences Rares, et Président du Comité Scientifique de l’Association France Alzheimer et de la Fondation pour la Recherche sur Alzheimer.

Alzheimers disease is named after Dr. Alois Alzheimer. In 1906, Dr. Alzheimer noticed changes in the brain tissue of a woman who had died of an unusual mental illness. Alzheimer's is an irreversible, progressive brain disorder that slowly destroys memory and thinking skills, eventually, the ability to carry out the simplest tasks.

James Keach has been a part of the film industry as an actor, director, writer, and producer. He has appeared in over fifty feature films and has produced and directed hundreds of hours of television. His most recent success was the award-winning documentary “Glen Campbell…I’ll Be Me,” which showed the legendary singer’s unprecedented “Goodbye Tour” after he was diagnosed with Alzheimer’s disease. James’ 2018 documentary feature film, “Augie,” tells the story of Augie Nieto, the genius entrepreneur and LifeFitness founder who was diagnosed with ALS over a decade ago and how he continues to work every day to find the cure for the disease. Before that, James has produced “Walk the Line,” for which the Producerʼs Guild of America nominated him Motion Picture Producer of the Year. The film was also nominated for several Academy and Golden Globe awards, winning the Golden Globe for Best Motion Picture and garnering Reese Witherspoon her Academy Award for Best Actress. On This Episode: A discussion of James’ gripping new documentary, “Turning Point.” The filmmaker takes us inside the quest for the first medication that could treat the underlying process of Alzheimer’s disease, more than a century after Dr. Alois Alzheimer first described the brain disorder that slowly destroys memory and cognitive skills. Along the way, we meet the people behind these grand experiments: the scientists driven as much by personal conviction as professional innovation. Twitter: @randallkjones @siriouslysusan @_BrightFocus @turning_point18 Instagram: @RandallKennethJones @SiriouslySusan @BrightFocus Facebook: https://www.facebook.com/TurningPointMovie2018/ Join us in the Jones.Show Lounge on Facebook www.RandallKennethJones.com www.SusanCBennett.com www.TurningPointMovie.com www.BrightFocus.org

Sa découverte ne remonte qu’au début du siècle dernier. Alois Alzheimer psychiatre, neurologue et neuropathologiste allemand travaillait à l’hôpital de Francfort en 1906 lorsqu’il a pu autopsier le cerveau d’une patiente qu’il avait suivie de son vivant. Auguste Deter était entrée pour démence, mais souffrait en fait d’une atrophie du cerveau, des hippocampes plus précisément. D’autres médecins constateront les résultats d’Alois Alzheimer par la suite.  Depuis, la recherche a bien évidemment progressé en la matière, mais les moyens préventifs ne sont toujours pas concluant. Seule une étude, sur des enfants pré-disposés génétiquement…

Sa découverte ne remonte qu'au début du siècle dernier. Alois Alzheimer psychiatre, neurologue et neuropathologiste allemand travaillait à l'hôpital de Francfort en 1906 lorsqu'il a pu autopsier le cerveau d'une patiente qu'il avait suivie de son vivant. Auguste Deter était entrée pour démence, mais souffrait en fait d'une atrophie du cerveau, des hippocampes plus précisément. D'autres médecins constateront les résultats d'Alois Alzheimer par la suite. Depuis, la recherche a bien évidemment progressé en la matière, mais les moyens préventifs ne sont toujours pas concluant. Seule une étude, sur des enfants pré-disposés génétiquement à la maladie, est actuellement en cours. Des médicaments « anti-Alzheimer » leur sont donnés, mais les résultats de ces recherches ne pourront être connus que lorsque ces enfants auront l'âge d'être atteint, au delà de leur 50 ans. En attendant, la communauté scientifique préconise de manger du poisson gras, de se tenir en bonne forme cardio-vasculaire. Les effets des perturbateurs endocriniens sur le cerveau ne sont, eux, pas encore confirmés. Il ne reste plus que les soins, mais là non plus, les traitements ne sont pas concluants. Alors certains, en plus des médicaments, proposent d'entraîner la mémoire, notamment avec la musicothérapie. Parce qu'avec la musique tous les mots sont plus doux ! Les symptômes s'atténuent le temps de la chanson, mais cette pratique ne soigne pas encore les troubles du comportement, difficultés à communiquer, à se concentrer, à se déplacer, désorientation spatio-temporelle, négligence concernant l'hygiène corporelle… Le Labo se lit aussi sur les réseaux ! Tous les mercredis, à 19h, retrouvez le thread de l'émission Invitée :Claire Boutoleau-Bretonnière, neurologue au Centre Mémoire Ressources et Recherche du CHU de Nantes Crédits :Une émission préparée et animée par Agathe Petit avec Jérémy Freixas, Solenne Lhéritier et Dounia Saez.

Descrita em 1906 pelo psiquiatra e neuropatologista alemão Alois Alzheimer, essa doença incurável sempre esteve associada à velhice.E, devido aos seus sintomas, muitas vezes é confundida com esclerose ou demência.Saiba mais sobre o Mal de Alzheimer neste episódio do podcast Naruhodo! — no papo entre o leigo curioso, Ken Fujioka, e o cientista PhD, Altay de Souza.*Naruhodo! é o podcast pra quem tem fome de aprender. Ciência, senso comum, curiosidades, desafios e muito mais. Com o leigo curioso, Ken Fujioka, e o cientista PhD, Altay de Souza.Edição: Reginaldo Cursino.naruhodo.b9.com.br

Dr. Alois Alzheimer, a German psychiatrist and neuropathologist is credited with identifying the first published case of "presenile dementia" in 1907, a condition that is now called Alzheimer's disease.

Im Gespräch mit der Autorin Dr. Silke Kirch über ihr Buch "Das Murmeln der Auguste Deter"

Alois Alzheimer war der erste, der die heute nach ihm benannte Alzheimer Demenz im Detail beschrieb. Eine Patientin war in relativ jungem Alter verwirrt in seine Obhut gegeben worden und er zeichnete nicht nur ihre Symptome auf sondern analysierte auch nach ihrem Tod die Veränderungen in ihrem Gehirn...

In 1901, the German psychiatrist Dr Alois Alzheimer treated a 51-year-old woman, Auguste Deter, who had developed a type of dementia. The illness he documented became known as Alzheimer’s disease. We speak to Professor Konrad Maurer, who discovered Dr Alzheimer's original case file on Auguste Deter, which had been lost for almost a century. Photo: Auguste Deter photographed in the psychiatric hospital in Frankfurt where Dr Alzheimer worked, c.1901

详细内容，请关注我们今天的微信，搜索：英语环球 NEWSPlus British scientists say that making basic lifestyle changes helps to prevent the onset of Alzheimer's disease and other forms of dementia. British health charity the Age UK reviewed academic studies and data and found that around 76 percent of cognitive decline is accounted for by lifestyle and other environmental factors including level of education. The analysis suggests "5 simple and effective steps" that people can take to maintain brain health and reduce their risk of developing dementia. The lifestyle factors include regular physical exercise, eating a healthy diet, not smoking, and drinking alcohol in moderation. In addition, preventing diabetes, high blood pressure and obesity were also found to reduce the risk of dementia. onset n. 开始 与beginning/start不同的是，onset通常描述那些令人不快的、负面的东西。 例句： The onset of depression often follows a traumatic experience. (抑郁症常常在遭受创伤的经历后开始发作。) Alzheimer's disease n. 阿尔茨海默病，临床表现为认知和记忆功能不断恶化，日常生活能力进行性减退，并有各种神经精神症状和行为障碍。该病是老年性痴呆的一种，多发生于中年或老年的早期，因德国医生阿尔茨海默（Alois Alzheimer）最先描述而得名。 dementia n. 痴呆 相关词汇：senile dementia n. 老年性痴呆 cognitive decline n. 认知功能衰退 account for 高频短语，有很多意思，最常用的包括：1. 说明、解释（原因、理由）；2. （在数量、比例上）占；3. 对…负责。该新闻稿里的account for属于第一种情形。 例句： If you cannot account for your absence, you will automatically get an F for missing the final exam. （如果你无法说明你为什么缺席，那你会因为错过期末考自动得到不及格的分数。） That is one of the richest cities in the country, as the poor account for just one percent of the population. (那是全国最富裕的城市之一，穷人只占人口数的百分之一。) Whoever was involved in the case must account for their actions that ultimately led to the loss of an innocent life. （所有涉案的人都要对他们的行为负责。正是他们的行为最终导致了一个无辜生命的终结。） eat a healthy diet v. 健康饮食 这种表达方式并不常见，不建议大家使用。更地道的说法是keep a healthy diet，或eat healthy（符合语法规则的表达方式是eat healthily，但因eat healthy更顺口所以广为流传，被大众接受）。 diabetes/high blood pressure/obesity n. 糖尿病、高血压、过度肥胖

Die Erkrankung war rätselhaft, aber Alois Alzheimer forschte und fand eine Erklärung: Am 3. November 1906 beschrieb der Psychiater, warum einige seiner Patienten ihr Gedächtnis verloren hatten. Autorin: Christiane Neukirch

Alois Alzheimer, who described the first case of the disease now named after him, would have been 150 years old this week. But what have we discovered about the disease since he presented the first Alzheimer's case over 100 years ago? And how can fruit flies, arm hair and video games untangle the most significant threat to our generation? Plus, in the news, how making mosquitoes male could reduce malaria, protecting astronauts from solar radiation, and why is beetle sex a sticky situation...

Alois Alzheimer, who described the first case of the disease now named after him, would have been 150 years old this week. But what have we discovered about the disease since he presented the first Alzheimer's case over 100 years ago? And how can fruit flies, arm hair and video games untangle the most significant threat to our generation? Plus, in the news, how making mosquitoes male could reduce malaria, protecting astronauts from solar radiation, and why is beetle sex a sticky situation... Like this podcast? Please help us by supporting the Naked Scientists

Alois Alzheimer, who described the first case of the disease now named after him, would have been 150 years old this week. But what have we discovered about the disease since he presented the first Alzheimer's case over 100 years ago? And how can fruit flies, arm hair and video games untangle the most significant threat to our generation? Plus, in the news, how making mosquitoes male could reduce malaria, protecting astronauts from solar radiation, and why is beetle sex a sticky situation... Like this podcast? Please help us by supporting the Naked Scientists

In Dr. Peter Whitehouse's book, The Myth of Alzheimer's: What You Aren't Being Told About Today's Most Dreaded Diagnosis, Dr. Whitehouse and his protégé, Daniel George, address the very foundation of our cultural and social relationships to the most dreaded disease of modern times. First described in 1907 by Alois Alzheimer, this disease has grown into a "$100-billion-a-year marketing and research juggernaut, with more than 25 million afflicted worldwide."

9 November 2011 - Introduction by Professor Sir John Tooke, Vice-Provost (Health) and Head of UCL School of Life & Medical Sciences. Speakers include Martin Orrell, Professor of Ageing and Mental Health, UCL Mental Health Sciences Unit: "Memory lane - the way ahead for better treatment in dementia". Nick Fox, Professor of Neurology, UCL Institute of Neurology: "Seeing what Alois Alzheimer couldn't see - imaging the onset and progression of Alzheimer's disease". John Collinge, Professor of Neurodegenerative Disease, UCL Institute of Neurology: “Molecular mechanisms and rational treatment of prion disease: implications for the commoner dementias”. Panel discussion with: Gill Livingston, Professor of Psychiatry of Older People, UCL Mental Health Sciences Unit, Katy Judd, Consultant Nurse at the National Hospital for Neurology and Neurosurgery, Chair: Professor Patrick Maxwell, Dean of the Faculty of Medical Sciences

9 November 2011 - Introduction by Professor Sir John Tooke, Vice-Provost (Health) and Head of UCL School of Life & Medical Sciences. Speakers include Martin Orrell, Professor of Ageing and Mental Health, UCL Mental Health Sciences Unit: "Memory lane - the way ahead for better treatment in dementia". Nick Fox, Professor of Neurology, UCL Institute of Neurology: "Seeing what Alois Alzheimer couldn't see - imaging the onset and progression of Alzheimer's disease". John Collinge, Professor of Neurodegenerative Disease, UCL Institute of Neurology: “Molecular mechanisms and rational treatment of prion disease: implications for the commoner dementias”. Panel discussion with: Gill Livingston, Professor of Psychiatry of Older People, UCL Mental Health Sciences Unit, Katy Judd, Consultant Nurse at the National Hospital for Neurology and Neurosurgery, Chair: Professor Patrick Maxwell, Dean of the Faculty of Medical Sciences

1906 sah Alois Alzheimer als erster Wissenschaftler eigenartige pathologische Strukturen im Gehirn einer Patientin mit massivem Gedächtnisverlust. Sie litt an einer Erkrankung, die später nach ihrem Arzt benannt wurde. Mittlerweile ist die Alzheimer-Erkrankung eine der häufigsten Todesursachen. Der Biochemiker Professor Christian Haass vom Adolf-Butenandt-Institut erforscht seit Jahren erfolgreich die molekularen Ursachen des Leidens und hat sich in letzter Zeit wegen einiger Ähnlichkeiten in der Pathologie auch der Parkinson-Erkrankung zugewandt.

A principios del siglo pasado, el médico Alois Alzheimer observó en una paciente una pérdida progresiva de la memoria que condujo a la posterior aparición de demencia. Al realizarle la autopsia, Alzheimer observó la presencia de dos estructuras aberrantes, las placas seniles y los ovillos neurofibrilares. De esta manera describió la enfermedad que lleva su nombre. La senilidad es un factor de riesgo para padecer la enfermedad, patología donde además de la presencia de las placas seniles y ovillos neurofibrilares, también se producen un decrecimiento en las interacciones (sinapsis) entre neuronas, y una muerte neuronal, siendo las neuronas colinérgicas las más afectadas. Actualmente, como tratamiento paliativo se usan fármacos que intentan mantener la funcionalidad de las neuronas colinérgicas, y paralelamente se siguen buscando otros fármacos más específicos para la enfermedad. Para tener un buen modelo de ensayo se están utilizando ratones transgénicos en dónde se expresan las placas, los ovillos, o ambos, para ser utilizados como dianas terapéuticas de nuevos fármacos.Más información de este acto