Podcasts about PSF

Want to learn more about investing in real estate? Visit https://www.therealestateinvestingclub.comInterested in investing in my projects? Visit https://www.kaizenpropertiesusa.comTHE ANTI-MULTIFAMILY STRATEGY: WHY INDUSTRIAL IS KING

Michael Olise's been Bayern's best player in an awkward season that ended in hilariously awkward fashion… at least for first time trophy winners, Harry Kane and Eric Dier. Join Gabby, Coach, and Deen for ruminations on backing into a league title and the happenings in Serie A, La Liga, Ligue Un, and the Premier League. Tap in! PS: “F**k Chelsea” - Gabby.

In dieser ganz persönlichen My Way-Folge nehme ich dich mit hinter die Kulissen meiner großen Umfrage unter den Lesenden meines Motivations-Letters.

Welcome back to the Rural Round-up. This show is produced in association with the Scottish Government. On today's episode, we're joined by George Chalmers & Tiffany Stephenson who bring us their Spring Update, with information on the “New Deal for Agriculture”, NVZ, claim deadlines for PSF & AECS Capital claims, an update on h5n1, and a market update. Related ResourcesPreparing for Sustainable Farming (PSF) Avian influenza (bird flu) outbreaks - gov.scot Claims and payments For more information, visit www.FAS.scot Twitter: @FASScot Facebook: @FASScot National Advice Hub Phone: 0300 323 0161 Email: advice@fas.scot

Bill Kanasky, Jr., Ph.D. shares ideas on how to upgrade your voir dire by applying measurement. One of the primary purposes of voir dire is to elicit information and Bill talks about ways to extract information from jurors to get accurate responses. Bill discusses how to handle oral questioning during voir dire, including the use of a 0-10 scale and asking jurors to give one reason for their number. After going over the scientific methodology for this approach to data collection, Bill talks about the art aspect of voir dire: the setup of the question, the answer set/options given to the jurors, and what to do with their answers. As an example, when you get negative information from a juror, you don't want to punish that juror with your reaction because you want to identify other jurors who share that same perspective so you can strike them. Reacting negatively to a juror's response could shut down other jurors who may feel the same way but want to avoid your negative reaction. Lastly, Bill talks about how to do this in Federal court or if you are really short on time. Watch the video of this episode: https://www.courtroomsciences.com/r/Psf

Willkommen zur ersten MyWay Folge im Jahr 2025!Ich wünsche dir ein erfolgreiches und glückliches neues Jahr. Im Jahr 2024 habe ich vieles gelernt, insbesondere wie essentiell gute Routinen sind. Außerdem spreche ich über meine emotionalen Herausforderungen und die Bedeutung von Strategien, um nicht in alte Essgewohnheiten zu verfallen. Es geht vor allen Dingen darum, alternative Wege und den richtigen Umgang mit Emotionen zu finden. Prävention, Stressreduktion und guter Schlaf sind hierbei u.a. entscheidende Faktoren. Gemeinsam reflektieren wir über meine berufliche Einstellung und wie ich mit Stress umgehe. Schließlich teile ich meine Pläne für 2025, inklusive meiner Strategie. PS: Fünf-Sterne-Alarm:Wenn dir die Episode gefallen hat, lass doch ein paar Sterne auf Spotify oder deiner Lieblings-Podcast-Plattform da. Du weißt ja, 5 Sterne machen glücklich – also zumindest mich!

As people enter their 50s, many start to shift their focus from rapid growth to preserving the wealth they've built over the years, particularly in real estate. Yu Rong and George Peng discuss how property investment strategies should evolve during this consolidation phase, ensuring financial stability while still seizing opportunities for growth.   They dive into the current state of the Singapore property market, examining the slight uptick in property prices and how this might align with anticipated interest rate reductions next year. With 2025 on the horizon, they provide a thoughtful analysis of how these shifts could impact property prices and market sentiment moving forward. You'll also hear a real-life strategy for single-income families looking to expand from one property to two, along with a deeper understanding of how interest costs can impact your decisions.   Tune in for a comprehensive understanding of how to make strategic decisions in real estate when making big moves into the next chapter of life!   Timestamps 00:00 Intro 01:03 “Can you upgrade to another property in your Winter Season?” (Continue from episode 1) 03:44 Life-stage Investing 06:33 Yu Rong client case study 09:15 “Is aiming to get 20% returns in property investment better than using other investment methods?” 17:11 Property price increase in Q3 statistics 22:59 Two differing opinions when property prices are at an “all time high” 25:51 Price projections and market sentiment predictions for 2025 27:24 Factors that make Singapore a safe haven for property buying 28:59 Price projections and market sentiment predictions for 2025 (Continue) 30:41 “Why are stress test percentages dropping?” 31:24 Price projections and market sentiment predictions for 2025 (Continue) 39:46 “Do you foresee any cooling measure being introduced?” 41:49 Lower level large units reaching highest quantum gain 44:17 Resale seller/owner sentiments 46:31 Increase in PSF pricing in 2025 47:22 “Do you think high quantum 4/5 bedder buyers will crossfire into the landed segment and have a tough time exiting?” 51:03 Increasing “hype” and excitement at new launch show flats post COVID 51:59 “People are underestimating income/asset value of private property participants in their 30s.” 52:38 George's client case study 53:34 “People are underestimating income/asset value of private property participants in their 30s.” (Continue) 57:51 Outtakes

Myths and misconceptions often hold buyers back in Singapore's property market, leaving many unsure of how to maximise returns or navigate rising costs effectively. This week on Nuggets On The Go, Melvin Lim, George, and Yu Rong from PropertyLimBrothers explore deep into the strategies that help investors and upgraders navigate key decisions.   They talk about the impact of “coordinated psychology” in new launches, the importance of harmonised floor plans, and why focusing on quantum over PSF can lead to better investment outcomes. They also discuss practical challenges such as saving for down payments, managing the resale versus new launch debate, and reframing monthly instalments as “forced savings” for HDB upgraders. Tackling whether fully paying for property is the best move, the episode provides insights into balancing financial commitments with long-term returns.   Learn about the alternative strategies for buyers, practical financial planning approaches, and the impact of shifting interest rates on Singapore's property market. All these and more on this episode!   Timestamps 00:00 Intro 00:57 “What is Herd Mentality?” 02:04 “Why do people buy into New Launch?” 03:44 “Which New Launch should I buy for the most capital appreciation?” 08:25 “Should you fully pay for their property without loans?” 11:39 New Launch vs Resale 15:45 “What is the fastest way for new buyers to save up for a down payment on a New Launch?” 20:54 “Should you keep your HDB or upgrade to a Condo?” 28:25 “Can you upgrade to another property in your Winter Season?” 34:06 A lot of projects TOP in 2027 34:55 Part 2 Teaser 35:24 Outtakes

During his time at Ohio University's BFA Acting Program, TT participated as a Scribe of their BIPOC theater, Vibrancy Theater, and an alumnus of Shakespeare & Company. Most recently, TT has appeared in Romeo and Juliet (‘Romeo' at PSF), As You Like It (Orlando), Camden Shakespeare Festival; A Midsummer Night's Dream (‘Demetrius' at Cap21); Yerma (‘Victor' at Vibrancy Theater); and The Motherf****r with the Hat (‘Ralph D.' at Ohio University). “My goal is to change people through stories that matter, standing up for the unheard and uplifting their stories everywhere.” To my friends, family, and Shakes&Co. faculty/cohort, I love you all, let it rip. Instagram: @timothy_oh49 To try a free Broadway fitness program visit: https://builtforthestage.com/ ANNOUNCING EXCLUSIVE FLOOR SEATS AND $49 IN-PERSON RUSH AND DIGITAL LOTTERY TICKETS SAM GOLD'S NEW PRODUCTION OF WILLIAM SHAKESPEARE'S A LIMITED NUMBER OF FLOOR SEATS WILL PUT AUDIENCES AT THE EDGE OF THE ACTION EVERY NIGHT! Learn more about your ad choices. Visit megaphone.fm/adchoices

During his time at Ohio University's BFA Acting Program, TT participated as a Scribe of their BIPOC theater, Vibrancy Theater, and an alumnus of Shakespeare & Company. Most recently, TT has appeared in Romeo and Juliet (‘Romeo' at PSF), As You Like It (Orlando), Camden Shakespeare Festival; A Midsummer Night's Dream (‘Demetrius' at Cap21); Yerma (‘Victor' at Vibrancy Theater); and The Motherf****r with the Hat (‘Ralph D.' at Ohio University). “My goal is to change people through stories that matter, standing up for the unheard and uplifting their stories everywhere.” To my friends, family, and Shakes&Co. faculty/cohort, I love you all, let it rip. Instagram: @timothy_oh49 To try a free Broadway fitness program visit: https://builtforthestage.com/ ANNOUNCING EXCLUSIVE FLOOR SEATS AND $49 IN-PERSON RUSH AND DIGITAL LOTTERY TICKETS SAM GOLD'S NEW PRODUCTION OF WILLIAM SHAKESPEARE'S A LIMITED NUMBER OF FLOOR SEATS WILL PUT AUDIENCES AT THE EDGE OF THE ACTION EVERY NIGHT! Learn more about your ad choices. Visit megaphone.fm/adchoices

Biden imposes a “0” quota on TIB imports of fine-denier PSF. Listen for details on Two Minutes in Trade. 

Willkommen zur 11. Episode meines Sonderformats "My Way" im "Abspecken kann jeder" Podcast!

Josh and Kurt talk to Seth Larson from the Python Software Foundation about security the Python ecosystem. Seth is an employee of the PSF and is doing some amazing work. Seth is showing what can be accomplished when we pay open source developers to do some of the tasks a volunteer might consider boring, but is super important work. Show Notes Seth Larson XKCD PGP Signature Seth's Blog Python and Sigstore Deprecating PGP - PEP 761 Python SBOMs  

Willkommen zur zehnten Episode meines Sonderformats "My Way" im "Abspecken kann jeder" Podcast!

Ce matin, les journalistes et experts de RFI répondaient à vos questions sur un projet de modification de la loi électorale tunisienne, le fils du président ougandais qui renonce à se présenter à la présidentielle et la politique de désengorgement carcéral en RDC. Tchad : que sait-on de la disparition du leader du PSF ?  Depuis vendredi (20 septembre 2024), Robert Gam, le secrétaire général du Parti socialiste sans frontières n'a plus donné signe de vie. Le PSF accuse les services secrets de l'avoir enlevé. Sur quelles preuves sont fondées ces accusations ?  Avec François Mazet, journaliste au service Afrique de RFI.   Tunisie : vers une réforme de la loi électorale à quelques jours de la présidentielle ?  Alors que la campagne électorale bat son plein, 34 députés - dont certains sont pro-pouvoir - ont déposé un projet d'amendement de la loi électorale. Ils proposent que l'élection présidentielle soit actée par la Cour d'appel de Tunis et non plus par le Tribunal administratif. Quelles conséquences ce changement peut-il avoir sur le scrutin ? Comment réagissent l'opposition et la population face à cette situation ?  Avec Amira Souilem, correspondante de RFI à Tunis.   Ouganda : le fils du président renonce à sa candidature  Après avoir annoncé sa candidature à la présidentielle de 2026, le général Muhoozi Kainerugaba, fils du président Yoweri Museveni, est finalement revenu sur ses propos et assure qu'il ne se présentera pas. Comment expliquer cette volte-face ?Avec Kristof Titeca, maître de conférences à l'Institut des Politiques de Développement à l'Université d'Anvers.  RDC : vers un désengorgement des prisons ? Le ministre de la Justice, Constant Mutamba, a fait libérer près de 1 700 détenus de la prison de Makala à Kinshasa. Le gouvernement veut ainsi lutter contre la surpopulation carcérale. Comment s'organise le désengorgement des prisons ? De nouvelles libérations sont-elles attendues ?  Avec Trésor Kibangula, analyste politique à Ebuteli, Institut congolais de recherche sur la politique, la gouvernance et la violence.

Ce matin, les journalistes et experts de RFI répondaient à vos questions sur l'enquête sur la mort de Yaya Dillo au Tchad, la création d'un pool judiciaire et financier au Sénégal et les juges élus par un vote populaire au Mexique. Liban : comment les bipeurs ont-ils explosé ? Au Liban, des milliers de bipeurs appartenant à des membres du Hezbollah ont explosé simultanément faisant une dizaine de morts et plus de 2 800 de blessés. Cette attaque inédite par son ampleur et son mode opératoire est attribuée à Israël. Sait-on comment tous ces appareils ont-ils été piégés ? Quel a été le mode opératoire ? Avec Franck Alexandre, journaliste spécialiste des questions de défense à RFI.  Tchad : où en est l'enquête sur la mort de Yaya Dillo ? Au Tchad, sept mois après la mort de l'opposant Yaya Dillo, le Parti socialiste sans frontières demande une enquête sur la mort de son président et réclame la libération des militants arrêtés lors des évènements des 27 et 28 février 2024. Où en est l'enquête promise à l'époque par le gouvernement ? Pourquoi des membres du PSF sont-ils encore détenus à la prison de Koro-Toro ?  Avec François Mazet, journaliste au service Afrique de RFI. Sénégal : création d'un nouvel instrument judiciaire Le gouvernement sénégalais vient de mettre en place un pool judiciaire et financier pour lutter contre la corruption. Qu'est-ce qui différencie ce pool de magistrats de la Cour de répression de l'enrichissement illicite, créée sous le président Abdou Diouf ?   Avec Léa-Lisa Westerhoff, envoyée spéciale permanente de RFI au Sénégal.   Mexique : les juges seront élus par le peuple C'est une première mondiale. Au Mexique, le président Lopez Obrador a promulgué la loi qui prévoit que tous les juges et magistrats du pays seront désormais élus par un vote populaire. Pourquoi cette réforme judiciaire est-elle autant controversée ? Quelles pourraient être les conséquences ?   Avec Achim Lipold, journaliste au service internationale de RFI.

Topics covered in this episode: “We must replace uwsgi by something else” Let's build and optimize a Rust extension for Python Fake recruiter coding tests target devs with malicious Python packages Monthly PSF Board Office Hours Extras Joke Watch on YouTube About the show Sponsored by ScoutAPM: pythonbytes.fm/scout Connect with the hosts Michael: @mkennedy@fosstodon.org Brian: @brianokken@fosstodon.org Show: @pythonbytes@fosstodon.org Join us on YouTube at pythonbytes.fm/live to be part of the audience. Usually Monday at 10am PT. Older video versions available there too. Finally, if you want an artisanal, hand-crafted digest of every week of the show notes in email form? Add your name and email to our friends of the show list, we'll never share it. Michael #1: “We must replace uwsgi by something else” uWSGI is now in maintenance mode: https://uwsgi-docs.readthedocs.io/en/latest/ The project is in maintenance mode (only bugfixes and updates for new languages apis). Do not expect quick answers on github issues and/or pull requests (sorry for that) A big thanks to all of the users and contributors since 2009. Reasonable options look like: granian uvicorn hypercorn gunicorn (potentially with uvicorn workers for async) Brian #2: Let's build and optimize a Rust extension for Python Itamar Turner-Trauring Example: algorithm for approximating the number of unique values in a list Comparison to non-approximation non-approx is faster but uses way more memory Rust version Use Maturin and PyO3 Pull in Rust dependencies (rand for random numbers) Optimization link-time optimization faster random store hashes only Future optimizations change algorithm maybe pass numpy array instead of Python list (I'd like to see that spedup) Michael #3: Fake recruiter coding tests target devs with malicious Python packages via python weekly GitHub projects that have been linked to previous, targeted attacks in which developers are lured using fake job interviews. Attackers posing as employees of major financial services firms. This previously happened via other means such as NPM This analysis revealed that the direct parent of the detected, malicious files is a PythonPYC file, meaning that once again the team encountered malware hidden in a compiled Python file. “The README files tell would-be candidates to make sure the project is running successfully on their system before making modifications.” What can you do (according to Michael)? Try out new packages in a docker container Work on code and projects using a VM which has snapshotting (to roll back completely after you're done) Fire up a Windows desktop in the cloud for the project then destroy it Brian #4: Monthly PSF Board Office Hours “The Office Hours will be sessions where you can share with us how we can help your community, express your perspectives, and provide feedback for the PSF.” “Unless we have a dedicated topic for a session, you are not limited to talking with us about the above topics, although the discussions should be focused on Python, the PSF, and our community. If you think there's something we can help with or we should know, we welcome you to come and talk to us!” Upcoming office hours October 8th, 2024: 9pm UTC November 12th, 2024: 2pm UTC December 10th, 2024: 9pm UTC January 14th, 2025: 2pm UTC February 11th, 2025: 9pm UTC March 11th, 2025: 1pm UTC April 8th, 2025: 9pm UTC May 13th, 2025: 1pm UTC (Live from PyCon US!) June 10th, 2025: 9pm UTC July 9th, 2025: 1pm UTC August 12th, 2025: 9pm UTC Extras Brian: PyCascades CFP closes Friday, Sept 20 PyCascades is in Portland in 2025 (Feb 8 & 9) uv now supports Python 3.13.0rc2 uv self update uv venv -p 3.13 Free threaded is still an open issue Michael: Big Python Humble Bundle with both of our products Get $1,800 worth of Python content and tools for $30 and contribute to charity Includes 5 Talk Python courses Several of Brian's and his book Djangonaut Space Session 3 Applications Open! I interviewed Sarah and Tushar on Talk Python AltTab: Windows alt-tab on macOS Joke: Election joke

Es ist wieder Zeit für eine "My Way"-Bonus-Folge.Diesmal plaudere ich über alles Mögliche: Gescheiterte Hochzeitspläne, meine Gruppenprogramme und warum ich manchmal zum unfreiwilligen "Diätpolizisten" am Esstisch werde. Also schnall dich an, es wird persönlich, witzig und wie immer direkt auf den Punkt! Hochzeits-Horror und Trauzeugen-Drama: Mein erstes Mal als Trauzeuge. Spoiler: Ich habe selten so viel Druck gespürt

Every year the core developers meet to discuss and propose the major changes and trends in Python itself. This invite-only conference of about 50 people happens inside PyCon in the US. Because it's private, we rarely get detailed looks inside this event. On this episode, we have Seth Michael Larson here to give us his account of the sessions and proposals. It's a unique look into the zeitgeist of CPython. Episode sponsors Posit Talk Python Courses Links from the show Seth on Mastodon: @sethmlarson@fosstodon.org Seth on Twitter: @sethmlarson Seth on Github: github.com The Python Language Summit 2024: blogspot.com PEP 2026: Calendar versioning for Python: github.com PSF authorized as a CVE Numbering Authority: python.org Recommends Memory-Safe Programming Languages: blogspot.com Watch this episode on YouTube: youtube.com Episode transcripts: talkpython.fm --- Stay in touch with us --- Subscribe to us on YouTube: youtube.com Follow Talk Python on Mastodon: talkpython Follow Michael on Mastodon: mkennedy

Meine Lieben!

Welcome back to NOTG whiteboard sessions with Melvin Lim from PropertyLimBrothers! In this episode, Melvin discusses why new launch buyers prefer fresh projects, introducing the 4 seasons (spring, summer, autumn, winter) concept in relation to land acquisition and the 5-year property cycle. He explains how these cycles impact pricing and investment decisions, providing valuable insights for timing your property investments.   The session highlights the median PSF of non-landed private new sales by region, showing significant price increases and the effects of past en bloc projects. Melvin covers our government's controlled release of land to manage property prices and discusses the ownership distribution of private properties, emphasising the niche market for condos and apartments. He also explains how cooling measures like SSD and the revised ABSD have increased the average holding period of properties, stabilising the market and reducing quick sales.   Curious about the future of property prices? Wondering how the decline in en bloc projects and new charges affect the market? Interested in why developers prefer GLS for its cleaner process? Melvin answers these questions and more!   Timestamps: 00:00 Intro 00:44 New whiteboard 01:11 Whiteboard Session Recap 01:40 4 seasons of land acquisition & 5 year cycle 04:36 New Launch sales by region 05:18 Era of HUDC en block projects 06:36 PSF surged to +$400 PSF in 2024 07:18 Non-Landed supply 09:53 Non-Landed ownership distribution 10:49 Non-Landed supply changes year-to-year 11:14 En blocs are at an all-time low. 12:01 Average holding period 13:07 Stable supply 13:37 +$400 PSF every 5 years 16:52 Applying the 4 seasons to the 5-years cycle 18:04 Seasons of where to expect new PSF benchmark 19:36 Preparation for each season 20:16 Summary 21:11 Outtakes

Are you in need of some simple tips to instantly ease your back or hip pain? Well, you've come to the right place - today's episode is going to deliver EXACTLY that! Recently, I joined Susie Pettit on the Love Your Life podcast to discuss the problem of back and hip pain. The questions that Susie asked were so good, the topics were so relevant, and the tips were so actionable, that we decided to air this conversation on the Self Care Simplified podcast, too! In this episode we discuss: What is happening in our bodies in midlife that wasn't happening before? How learning about the acronym PSF will help you with your back pain. The ONE quick thing you can do during your work day that positively impacts your metabolism AND mindset! How simple shifts with how we do our squats, shoulder rolls, and even take a breath (!) can help. Get ready to find out how some small, simple adjustments can have a BIG impact on your back pain! More Resources & Links The free Hip Course that helped Susie so much! The free 5-Day Core Tune Up program Listen to more of Susie's show here! Follow Megan on Instagram

Topics covered in this episode: PSF Elections coming up Cloud engineer gets 2 years for wiping ex-employer's code repos Python: Import by string with pkgutil.resolve_name() DuckDB goes 1.0 Extras Joke Watch on YouTube About the show Sponsored by ScoutAPM: pythonbytes.fm/scout Connect with the hosts Michael: @mkennedy@fosstodon.org Brian: @brianokken@fosstodon.org Show: @pythonbytes@fosstodon.org Join us on YouTube at pythonbytes.fm/live to be part of the audience. Usually Tuesdays at 10am PT. Older video versions available there too. Finally, if you want an artisanal, hand-crafted digest of every week of the show notes in email form? Add your name and email to our friends of the show list, we'll never share it. Brian #1: PSF Elections coming up This is elections for the PSF Board and for 3 bylaw changes. To vote in the PSF election, you need to be a Supporting, Managing, Contributing, or Fellow member of the PSF, … And affirm your voting status by June 25. See Affirm your PSF Membership Voting Status for more details. Timeline Board Nominations open: Tuesday, June 11th, 2:00 pm UTC Board Nominations close: Tuesday, June 25th, 2:00 pm UTC Voter application cut-off date: Tuesday, June 25th, 2:00 pm UTC same date is also for voter affirmation. Announce candidates: Thursday, June 27th Voting start date: Tuesday, July 2nd, 2:00 pm UTC Voting end date: Tuesday, July 16th, 2:00 pm UTC See also Thinking about running for the Python Software Foundation Board of Directors? Let's talk! There's still one upcoming office hours session on June 18th, 12 PM UTC And For your consideration: Proposed bylaws changes to improve our membership experience 3 proposed bylaws changes Michael #2: Cloud engineer gets 2 years for wiping ex-employer's code repos Miklos Daniel Brody, a cloud engineer, was sentenced to two years in prison and a restitution of $529,000 for wiping the code repositories of his former employer in retaliation for being fired. The court documents state that Brody's employment was terminated after he violated company policies by connecting a USB drive. Brian #3: Python: Import by string with pkgutil.resolve_name() Adam Johnson You can use pkgutil.resolve_name("[HTML_REMOVED]:[HTML_REMOVED]")to import classes, functions or modules using strings. You can also use importlib.import_module("[HTML_REMOVED]") Both of these techniques are so that you have an object imported, but the end thing isn't imported into the local namespace. Michael #4: DuckDB goes 1.0 via Alex Monahan The cloud hosted product @MotherDuck also opened up General Availability Codenamed "Snow Duck" The core theme of the 1.0.0 release is stability. Extras Brian: Sending us topics. Please send before Tuesday. But any time is welcome. NumPy 2.0 htmx 2.0.0 Michael: Get 6 months of PyCharm Pro for free. Just take a course (even a free one) at Talk Python Training. Then visit your account page > details tab and have fun. Coming soon at Talk Python: Shiny for Python Joke: .gitignore thoughts won't let me sleep

In the first episode of a special daily series during the 2024 ASCO Annual Meeting, Dr. John Sweetenham shares highlights from Day 1, including exciting data on the CROWN trial in NSCLC, the ASC4First study in chronic myeloid leukemia, and the effects of high-deductible health plans on cancer survivorship. TRANSCRIPT Dr. John Sweetenham: I'm Dr. John Sweetenham, the host of the ASCO Daily News Podcast. I'm delighted to bring you a special series of daily episodes from the 2024 ASCO Annual Meeting and to share my top takeaways on selected abstracts.   Today, I'll be reviewing exciting new data in chronic myeloid leukemia, remarkable outcomes for patients with ALK-positive non-small cell lung cancer, and a compelling study on the effects of high deductible health plans on cancer survivorship.   My disclosures are available in the transcript of this episode.   LBA6500, the ASC4FIRST trial, is a phase 3 combination of asciminib with the current standard of care tyrosine kinase inhibitors, those being imatinib, nilotinib, dasatinib and bosutinib for the first line treatment of patients with chronic myeloid leukemia. The data from this large multinational study, conducted in 29 countries, were presented by Dr. Timothy Hughes from the Royal Adelaide Hospital in Australia. Some patients with chronic phase CML respond well to tyrosine kinase inhibitor therapy, and about one-third may eventually be able to stop therapy and will remain in remission, the so-called treatment free remission or TFR. Unfortunately, almost half of patients eventually need to change therapy due to resistance and intolerance, and most patients will need to remain on therapy for many years, possibly for life.  Asciminib is the first BCR-ABL1 inhibitor to specifically target the ABL myristate pocket or STAMP and was designed to be highly potent but also highly specific, thus minimizing side effects and toxicity. In this large trial, which is the first randomized head-to-head comparison of asciminib with other tyrosine kinase inhibitors, 405 patients were randomized 1:1 to receive either asciminib at a dose of 80 milligrams daily or another investigator-selected TKI. The groups were well balanced for all patient characteristics, including ELTS risk. The primary objectives of the study were to compare the major molecular response rate at 48 weeks with an additional analysis for the patients who received imatinib as the investigator-selected TKI. With median follow-up at 16.3 months for patients receiving asciminib and 15.7 months for those receiving the other TKIs, the 48-week MMR rates were 68% for asciminib compared with 49% for the other investigators-selected TKIs.  The rates of MR4 after 48 weeks, a deep molecular response which is a prerequisite to be considered for treatment free remission, were 39% for asciminib compared to 21% for the investigator-selected TKI. Tolerability and safety were excellent for asciminib, with only 5% discontinued due to toxicity compared to 10% for the other TKI arm. Frequently observed toxicities with asciminib included thrombocytopenia and neutropenia. The investigators concluded that asciminib is the only agent to show a statistically significant improvement in efficacy and toxicity in this patient group when compared with all other TKIs, and that asciminib has the potential to become the preferred standard of care for the first line treatment of CML. Follow-up on the study continues, but there is no question that these are exciting and probably practice-changing results.  The next exciting study, LBA8503, was presented by Dr. Benjamin Solomon from the Peter MacCallum Cancer Centre in Melbourne, Australia. This presentation was an update of the CROWN study for patients with previously untreated advanced ALK-positive non-small cell lung cancer. Lorlatinib is a third-generation brain-penetrating ALK inhibitor which was compared with crizotinib in the CROWN-3 study. This phase 3 study enrolled 296 patients randomly assigned to lorlatinib 100 milligrams once daily or crizotinib 250 milligrams twice daily. The interim results showed a 72% reduction in the risk for progression or death with lorlatinib compared with crizotinib and formed the basis for the March 2021 FDA approval of the drug for metastatic ALK positive non-small cell lung cancer. A subsequent post hoc analysis at three years showed continued progression free survival benefit with lorlatinib compared with crizotinib.  Earlier today, Dr. Solomon presented a further post hoc analysis of the study at 60.2 months of median follow-up. Among the entire patient population, the median PFS was not reached with lorlatinib compared with 9.1 months with crizotinib. At 60 months, the PFS rate was 60% with lorlatinib compared with only 8% with crizotinib. The PSF benefits with lorlatinib were seen across all patient subgroups. The improved control of central nervous system metastatic disease, which was observed in the earlier reports, has been confirmed in this recent analysis. Among those patients with baseline brain metastases, the median PFS with lorlatinib was not yet reached compared with six months with crizotinib. More than half of patients with baseline brain metastases were progression free at 60 months.   But the benefit of lorlatinib is certainly not confined to patients with brain metastases. Lorlatinib also significantly improved progression-free survival among patients without metastases. At 60 months, 63% of patients without baseline brain metastases assigned to lorlatinib were progression free, compared with only 10% of those assigned crizotinib. These are remarkable results. As Dr. Solomon stated in his conclusion, 60% of patients on lorlatinib are still progression free and 92% are progression free in the brain. No new safety signals were seen and the improved efficacy over crizotinib was seen across all risk groups. These results are unprecedented in patients with ALK-positive non-small cell lung cancer.   Concerning data were presented today by Dr. Justin Barnes from Washington University. Dr. Barnes presented results from a retrospective study in Abstract 11005 which showed whether a patient with cancer has high-deductible health insurance can play a role in their survival. Although previous studies have shown care disparities for those with high-deductible plans, this report focuses specifically on effects on survival and concludes that cancer survivors with high-deductible health plans had a greater risk of mortality both overall and from cancer. High-deductible insurance was defined as costing between $1,200 and $1,350 annually for individual insurance, or between $2,400 and $2,700 annually for a family plan. Investigators used data from the U.S. National Center for Health Statistics National Health Interview Survey and linked them to files from the National Death Index to determine mortality rates. Included were more than 147,000 respondents aged between 18 and 84 years who did not have Medicaid. Among these individuals, 5.9% were cancer survivors. The concern for cancer survivors with these plans is that in addition to recurrence that could require costly treatments, there might be issues related to survivorship. Investigators found that overall survival was worse for those with a cancer diagnosis coupled with high-deductible health insurance, with a hazard ratio of nearly 1.5.   But when the researchers reviewed data from the general population without a history of cancer, they didn't find any association between high-deductible health insurance and outcomes. According to Dr. Barnes, the leading hypothesis is that patients with cancer who have a high-deductible plan delay workup for a potential new or recurrent cancer diagnosis or postpone or avoid other care. The results also indicated that survival among certain subgroups, such as non-Hispanic white patients, patients with higher incomes, and patients with at least a college or high school education, was worse for those with a high-deductible health plan, not the groups who are typically impacted by care disparities. It is possible that these individuals are more likely to select high-deductible health plans and that having these plans might counteract what might otherwise be adequate access to care.  A key take-home from this analysis is that cancer patients and survivors, whatever their racial, ethnic, or socioeconomic status, should have access to health plans with low deductibles and should be informed of the potential risks of their long-term health and survival when covered by high-deductible plans.   Join me again tomorrow to hear more top takeaways from ASCO24. If you value the insights that you hear on the ASCO Daily News Podcast, please remember to rate, review and subscribe wherever you get your podcasts.   Disclaimer:  The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity or therapy should not be construed as an ASCO endorsement.   Follow ASCO on social media:  @ASCO on Twitter  ASCO on Facebook  ASCO on LinkedIn    Disclosures: Dr. John Sweetenham: Consulting or Advisory Role: EMA Wellness

Guest Velda Kiara Panelist Richard Littauer Show Notes Today, host Richard has a conversation with guest Velda Kiara, a passionate open source developer. Velda discusses how open source has helped businesses, how it benefits both coders and non-coders, and how it can lead to career growth. She also talks about the challenges of open source, particularly in terms of finances and the sustainability of projects. The discussion also turns to Velda's attendance at OSCA fest in Lagos, Nigeria, and her involvement with Black Python Devs. Velda shares her personal journey of contributing to Django and other Python projects and tells us about her experience joining programs like Djangonaut Space and contributing to projects like Novu. Press download now to hear more! [00:00:10] The episode opens with Velda highlighting the ins and outs of open source, acknowledging that it allows for the use of software that businesses can monetize. She appreciates the good that comes from open source despite the criticism of some corporations. She acknowledges the pros and cons of open source, expressing hope that the pros will eventually outweigh the cons. [00:02:21] Richard introduces Velda and praises her answer and asks if she'd like to change her initial statement. Velda stands by her answer, expressing willingness to continue the discussion for further insights on open source. [00:03:31] Velda confirms her attendance at OSCA fest, mentioning he talk on building APIs with Django, DRF, and Open API, and discusses the importance of sustainability in growing the open source community in Africa. [00:04:34] Richard inquires about Velda's involvement with Black Panther Devs, and she explains the inception, its objectives, and activities like workshops and meetups that support the community. [00:07:12] The conversation shifts to encouraging newcomers to join open source, emphasizing roles beyond coding, such as project management and writing. [00:09:08] Richard and Velda discuss the challenges designers face in open source and the potential career benefits of contributing to open source, even for non-developers. Velda shares how open source helped her gain experience and improve skills, which is beneficial at any career level, and she discusses the “level up” aspect of open source and the learning opportunities it provides. [00:12:00] Richard explores into the sustainability of open source for late-stage careers and the challenges maintainers face. Velda suggests using open source for mentorship and ensuring project continuity by engaging contributors and sharing maintenance responsibilities. [00:14:02] What currently excites Velda about open source? She expresses her excitement about contributing to Django after building many websites with it and her positive experience at DjangoCon US, which she found to be an inclusive community. Also, she discusses Djangonaut Space, an eight-week program designed to assist new contributors like her in contributing to the Django framework or third-party packages. [00:16:28] Velda mentions her contributions to other Python projects, such as Novu, and her new experiences working with SDKs. She reflects on the learning process in open source and shares her excitement for exploring various Python projects and talks about how she started a newsletter called, “The Storytellers by Tales.” Quotes [00:12:36] “If you eventually want to not let the project die, you could easily use open source as a way to mentor another person who's going to help you maintain for a while if you want to retire or stop writing code in general.” Links SustainOSS (https://sustainoss.org/) SustainOSS Twitter (https://twitter.com/SustainOSS?ref_src=twsrc%5Egoogle%7Ctwcamp%5Eserp%7Ctwgr%5Eauthor) SustainOSS Discourse (https://discourse.sustainoss.org/) podcast@sustainoss.org (mailto:podcast@sustainoss.org) SustainOSS Mastodon (https://mastodon.social/tags/sustainoss) Open Collective-SustainOSS (Contribute) (https://opencollective.com/sustainoss) Richard Littauer Socials (https://www.burntfen.com/2023-05-30/socials) Velda Kiara X/Twitter (https://twitter.com/VeldaKiara) Velda Kiara LinkedIn (https://www.linkedin.com/in/veldakiara/) Velda Kiara Website (https://veldakiara.notion.site/veldakiara/Velda-Kiara-46aec24028fd4e8dbdba003097c18b5b) Black Python Devs (https://blackpythondevs.github.io/) KJay Miller (https://kjaymiller.com/) Djangonaut Space (https://djangonaut.space/) Novu (https://github.com/novuhq/novu) Sustain Podcast-Episode 169: Dawn Wages of PSF on organizing communities, ethical licenses, and more (https://podcast.sustainoss.org/169) Credits Produced by Richard Littauer (https://www.burntfen.com/) Edited by Paul M. Bahr at Peachtree Sound (https://www.peachtreesound.com/) Show notes by DeAnn Bahr Peachtree Sound (https://www.peachtreesound.com/) Special Guest: Velda Kiara.

Henry V; Prologue PrologueApril 30, 2024 In his second season as the Artistic Director of the Pennsylvania Shakespeare Festival, Jason King Jones brings a seemingly boundless energy and enthusiasm to the leadership role. This summer, PSF will produce 8 shows, the equivalent of a full regional theatre season, in just sixteen weeks. Click here for more information about Pennsylvania Shakespeare Festival Click here to follow along with the text. Click here to see a First Folio Version Click here to see a Scanned Version

[00:02:01] The Baltimore Orioles' potential. [00:04:30] G's bounce back season. [00:08:34] Yankees fans' high expectations. [00:10:25] Yankees fan frustrations. [00:13:38] Baltimore Orioles fun experience. [00:17:04] Dean Kramer's beautiful long hair. [00:22:08] AAA players joining the roster. [00:26:10] Vladdy's high expectations and performance. [00:29:21] Red Sox ownership and business. [00:31:18] Catcher Martín Maldonado's performance. [00:35:30] Twins' bullpen struggles and changes. [00:37:14] Brother teammates in MLB. [00:42:24] Sneaky good Kansas City Royals. [00:45:06] Stuffed spinach pizza sounds really good. [00:47:33] Chicago hot dog toppings. [00:52:30] Rangers bullpen concerns. [00:55:23] Kyle Tucker's impressive performance. [00:58:48] Jose Abreu's pressure to perform. [01:00:53] Ty France and Julio Rodriguez. [01:04:45] World Series predictions. [01:09:40] Max Scherzer's pitching future. [01:12:57] Angels lineup analysis. [01:15:47] Three Joses in the bullpen. [01:19:36] Hope for the team's success. [01:23:42] Fantasy baseball predictions. [01:26:08] Drinking games during PSF app. --- Support this podcast: https://podcasters.spotify.com/pod/show/suzy-fulton/support

Guest Mannie William Young Panelist Richard Littauer Show Notes In this episode, host Richard invites guest Mannie Young from Ghana's Python community to share his experiences in open source development. Mannie discusses his role as the Executive Director of the Python Software Community in Ghana and his involvement in organizing PyCon Africa. He provides insights into the significant growth of the Python community in Ghana and the various initiatives under it. He also discusses the Nigerian open source community's vibrancy, the Python community's development in Ghana, and reflects on his experiences at OSCA and Sustain events. Mannie touches on cultural differences affecting community sustainability and funding opportunities, and he shares insights on how to get involved with PyCon Africa and Python Ghana, highlighting the new PyClubs initiative. Hit download now to hear more! [00:00:59] Mannie mentions his active contribution to the Python software community and his roles as the Executive Director of Python Ghana and organizer of PyCon Africa. [00:02:02] Mannie discusses his experience at OSCA Fest 2023, insights from the Sustain Session, as well as Importance of Documentation in Open Source [00:06:14] Mannie explains the growth of the Python community in Ghana and its various initiatives, like PyLadies Ghana and PyData Ghana. [00:07:11] There's a discussion about OSCA's event in Lagos and the Sustain event. Although Mannie was not part of the organizing team this year, he shares some highlights from OSCA including great talks, diversity, and a welcoming environment. He also tells us about the Sustain workshops he attended, focusing on design and community. [00:10:04] The conversation shifts to compare the open source communities in Ghana and Nigeria, with an emphasis on social media presence and advocacy. [00:11:36] Mannie discusses the impact of being reserved on funding and opportunities in the Ghanaian open source community, along with the cultural differences affecting sustainability. [00:012:30] Richard and Mannie address a recent issue with DjangoCon and the PSF regarding discrepancies in approaches to funding and community support, along with cultural and legal considerations in Africa. [00:15:33] Richard inquires about how people can get involved with PyCon Africa, PyCon Ghana, and Mannie's communities. Mannie explains that preparations for PyCon Africa 2024 are underway and provides contact emails and websites. [00:17:08] Find out where you can follow Mannie and his blog on the web. Quotes [00:11:08] “If you don't blog about things, no one knows what you were doing.” Links SustainOSS (https://sustainoss.org/) SustainOSS Twitter (https://twitter.com/SustainOSS?ref_src=twsrc%5Egoogle%7Ctwcamp%5Eserp%7Ctwgr%5Eauthor) SustainOSS Discourse (https://discourse.sustainoss.org/) podcast@sustainoss.org (mailto:podcast@sustainoss.org) SustainOSS Mastodon (https://mastodon.social/tags/sustainoss) Open Collective-SustainOSS (Contribute) (https://opencollective.com/sustainoss) Richard Littauer Mastodon (https://mastodon.social/@richlitt) Mannie Young Website (https://www.mannieyoung.com/) Mannie Young LinkedIn (https://www.linkedin.com/in/mawy7/?originalSubdomain=gh) An Open Letter to the Python Software Foundation (Python Africa) (https://pythonafrica.blogspot.com/2023/12/an-open-letter-to-python-software_5.html) PyCon Ghana (https://gh.pycon.org/) PyClubs (https://www.pyclubs.org/) PyLadies Ghana (https://blog.pythonghana.org/series/pyladies) PyData Ghana (https://blog.pythonghana.org/series/pydata) OSCAfrica (https://oscafrica.org/about-us) Credits Produced by Richard Littauer (https://www.burntfen.com/) Edited by Paul M. Bahr at Peachtree Sound (https://www.peachtreesound.com/) Show notes by DeAnn Bahr Peachtree Sound (https://www.peachtreesound.com/) Special Guest: Mannie William Young.

Les réactions politiques s'enchainent après la mort de l'opposant Yaya Dillo, tué le 28 février lors de l'assaut donné par l'armée contre le siège de son parti. Le porte-parole du gouvernement a affirmé ce vendredi sur RFI que ce sont les hommes de Yaya Dillo qui ont ouvert le feu et contraint à la riposte. Il assure que s'il s'était rendu, la situation n'aurait pas dégénéré. Les soutiens de l'opposant dénoncent un assassinat. La version officielle ne satisfait pas non plus Max Kemkoye, du groupe de concertation des acteurs politiques, une plateforme d'opposition radicale à la transition, politiquement proche de celle de Yaya Dillo. RFI : Yaya Dillo et vous, vous étiez des opposants résolus à la transition depuis le début, comment est-ce que vous avez pris ces événements tragiques de la semaine ? Max Kemkoye : J'ai été atterré, profondément bouleversé. On s'est vus avec Yaya deux jours avant. On s'est appelé 24 heures avant. Au petit matin, j'ai appelé sur ses deux numéros privés. Ça ne sonnait plus, je m'en suis inquiété. Les amis et quelques partenaires qui m'ont approché pour en savoir plus, je leur ai dit ‘moi non plus je n'ai pas la position de Yaya, je ne sais pas s'il est mort ou vivant cette nuit-là'. Quand quelqu'un m'a appelé pour me donner la confirmation de la mort de Yaya, je n'en suis pas revenu, je m'en suis difficilement remis et ça continue encore. Mais, pourquoi je suis réconforté ? Simplement parce qu'il faut honorer la mémoire d'un grand camarade de lutte, comme Yaya Dillo.  Selon les autorités, ce sont les forces de défense et de sécurité qui ont répondu à des tirs venant des gens du PSF. Qu'est-ce que vous pensez de cette version ? Le gouvernement et les autorités judiciaires se sont lancés dans un narratif, mais c'est un vernis qui cherche à donner un habillage à un gros mensonge. Tous les Tchadiens le savent, y compris les éléments des forces de défense et de sécurité le savent. Nous exigeons d'abord des clarifications, mais des clarifications nettes. Ce sont des narratifs bidons du ministre de la Communication, du procureur de la République qui ne convainc personne. Nous exigeons du Premier ministre ce texte opposant qui a permis que tout ça arrive, qu'il vienne nous donner des explications claires, c'est à lui, le chef du gouvernement et le président de transition. Ils doivent nous donner des clarifications nettes. Ensuite, nous exigeons une enquête indépendante. Mais cette enquête indépendante, ce ne sera pas une enquête locale qui a été toujours biaisée et enterrée, comme des précédentes enquêtes. Et c'est là-dessus que nous attendons les partenaires et amis du Tchad. C'est là-dessus que nous attendons les Nations unies. C'est là-dessus que nous attendons l'Union africaine. Sans quoi nous n'allons pas accepter.Le ministre dit que si Yaya Dillo s'était rendu, la situation ne serait pas arrivée à une telle extrémité. Totalement faux. Est-ce que Yaya Dillo a reçu régulièrement une convocation venant du procureur de la République ? Non. Première, deuxième, troisième convocation, comme se veut la procédure et qu'à l'issue, si Yaya refuse d'obtempérer, le procureur de la République a la possibilité – avec les officiers de la police judiciaire, la gendarmerie et la police – d'interpeller ou de prendre Yaya Dillo pour l'astreindre à une contrainte par corps et de l'amener, puisque Yaya Dillo est un civil, il n'est pas militaire. Mais pourquoi procéder par une interpellation d'un civil avec une présence fortement armée, essentiellement des militaires, pour donner l'assaut, pour la reddition d'un civil, en tout cas d'un acteur politique ?Craignez-vous que cette situation amène des difficultés pour le Tchad, crée des tensions alors qu'on approche des élections ? La tension aujourd'hui, elle est pour nous qui continuons à parler. Mais nous sommes des candidats à la mort. La tension, elle est déjà là, les troubles sont déjà là. Le cocktail explosif, il est réuni mais ce que nous regrettons, c'est le facilitateur Felix Tshisekedi, qui s'est fendu dans un communiqué incompréhensible qui se permet de décrire une situation dont il n'a même pas les éléments d'appréciation. Pourquoi est-il allé si vite en besogne ? Mais ce n'était pas le cas, puisqu'il est l'appui inconditionnel de la junte au pouvoir. Il en fait usage pour produire son communiqué. Mais pour le reste, les Nations unies sont interpellées et avec en tête, les États-Unis qui apportent leur soutien inconditionnel à cette junte aujourd'hui qui tue les acteurs politiques, cette junte qui a tué déjà 300 jeunes Tchadiens qui sont sortis pour exercer leurs droits et dont on a accordé l'impunité, c'est à dire la licence de tirer pour tuer. Et nous pensons que les États-Unis d'Amérique, la France et au-delà l'ensemble de la communauté internationale incarnée par les Nations unies, ils ont la clé des solutions du problème du Tchad. S'ils en font usage, ils peuvent ouvrir les portes d'une accalmie, d'une stabilité pour avoir un processus conclusif et serein.À lire aussiAu Tchad, la mort de Yaya Dillo sème le trouble et l'inquiétude dans un contexte pré-électoral

Les journalistes et experts de RFI répondent également aux questions des auditeurs sur l'interruption de la grève générale en Guinée, sur la condamnation d'un migrant sénégalais au Royaume-Uni et sur le prix plancher de la noix de cajou en Côte d'Ivoire. Tchad : quelles conséquences après la mort de Yaya Dillo ? Selon le procureur, l'opposant tchadien et leader du Parti socialiste sans frontières (PSF) a succombé à ses blessures après des affrontements avec les militaires. Dans quelles circonstances est-il mort ? Son décès peut-il déclencher des tensions et perturber le démarrage du processus électoral ? Avec François Mazet, envoyé spécial à N'Djamena.  Guinée : grève suspendue après la libération d'un syndicaliste. En Guinée, la grève a été suspendue après la remise en liberté de Sekou Jamal Pendessa. Cette libération signe-t-elle la fin définitive du mouvement de protestation ? Avec la nomination du nouveau Premier ministre, la réouverture des médias est-elle possible ? Avec Sidy Yansané, journaliste au service Afrique de RFI.  Royaume-Uni : neuf ans de prison pour un migrant sénégalais Ibrahima Bah a été condamné pour homicide involontaire après le naufrage de l'embarcation qu'il pilotait. Quatre personnes y avaient trouvé la mort. Pourquoi a-t-il été condamné à une peine de prison aussi lourde alors qu'il se défend d'être un passeur ? Avec Guilhem Fabry, journaliste au service Afrique de RFI.  Côte d'Ivoire : chute du prix plancher de la noix de cajou Le ministre de l'Agriculture ivoirien a annoncé une baisse du prix plancher du kilo de la noix de cajou. De 315 F CFA en 2023, il passe à 275 F CFA. Comment expliquer cette baisse ? Pourquoi s'agit-il du prix le plus bas de la région ? Avec Pierre Ricau, spécialiste de la noix de cajou en Afrique de l'Ouest.  

Ce sera donc le 2 juin. Si la presse sénégalaise relaye cette date, annoncée hier jeudi par le président sénégalais, c'est plutôt celle du 2 avril, jour de la fin de son mandat qui préoccupe les journaux. « La date de mon départ reste absolument ferme », titre Sénégo qui cite Macky Sall.Et après, que peut-il se passer ? « Le brouillard plane sur l'avenir politique du Sénégal », nous dit Seneweb.Mais il n'y a pas pour autant 1 000 scénarios possibles. Rewmi cite le ministre de l'Intérieur : « Nous sommes dans une situation inédite, car la Constitution avait prévu trois cas de figure : l'empêchement, la démission et le décès. »Et ce sera au Conseil constitutionnel de trancher, poursuit Dakar actu : « Soit le conseil choisi que le président de la République ne peut pas partir, il reste en place pendant deux mois pour remettre la clé au président démocratiquement élu. Ou bien, le Conseil constitutionnel constate qu'il y a vacance de pouvoir et c'est le président de l'Assemblée nationale qui devient automatiquement président de la République. »Dans ce dernier cas, précise Dakar Matin : « Tout le processus électoral sera repris, il n'y a plus de droit acquis pour les 19 candidats, car le président de l'Assemblée national doit organiser de nouvelles élections. »Et puis il y a tout de même une dernière possibilité, relayée par l'avocat Abdoulaye Tine, membre de la coalition d'opposition F24 dans les colonnes de Dakar actu : « Si le président ne démissionne pas d'ici le 02 avril, l'opposition et les forces vives prendront leurs responsabilités car, elles ne comptent pas laisser le pouvoir sombrer. »Loi d'amnistie annoncée par Macky Sall lors du dialogue national« La loi d'amnistie ou le second assassinat des martyrs de 2021 à 2024 », titre Seneplus. Le site en ligne qui donne la parole au Collectif des universitaires pour la démocratie, groupe d'intellectuels sénégalais. Pour eux, « l'usage politicien de l'amnistie brouille toute perspective de réalisation d'un avenir collectif empreint de sérénité et d'apaisement ».Jeune Afrique constate que même au sein du camp présidentiel, l'idée ne fait pas l'unanimité. JA cite Samba Sy, ministre du Travail et secrétaire général du Parti de l'indépendance et du travail : « Je ne dis pas que nous ne devons pas nous réconcilier, mais n'oublions pas ce qu'il s'est passé pour que, demain, les mêmes causes ne produisent pas les mêmes effets. »Et le Monde Afrique cite un habitué du palais présidentiel qui assure que « Samba Sy a dit tout haut ce que pensent beaucoup d'élus de la majorité ». Et le quotidien constate que du côté de l'opposition, on voit dans la loi d'amnistie une manœuvre du président sénégalais : « Macky Sall et son équipe sont en réalité hantés par la perspective de devoir répondre de leurs actes, car le peuple ne pardonnera jamais », confie Thierno Alassane Sall, opposant et candidat à la présidentielle. Des arguments soutenus également par des organisations de la société civile, ajoute le Monde Afrique.Mais Jeune Afriquea sorti la calculette et constate que « le texte devrait, sans surprise, être voté par l'Assemblée nationale, où la coalition Benno Bokk Yakaar conserve 81 députés sur 165. La majorité présidentielle pourra également compter sur l'apport de voix des 24 élus du Parti démocratique sénégalais (PDS, de Karim Wade), son nouvel allié de circonstance au sein de l'opposition ».Mort de l'opposant Yaya Dillo au TchadTrès factuelle, la presse tchadienne se fait l'écho de l'annonce par le procureur de la république de la mort de Yaya Dillo lors de « l'assaut au siège du Parti socialiste sans frontières » ce mercredi 28 février.Tchad Vision relaye le bilan :« Une dizaine de morts, de nombreux blessés et 26 interpellations. »Le pure player qui ajoute que « d'après la version officielle, les forces de l'ordre se sont déployées en riposte, à l'attaque des locaux des services de renseignements ».Jeune Afrique précise les circonstances et les raisons de cette attaque : « Des éléments du PSF sont arrivés à bord de onze véhicules afin de libérer Abakar Torabi, le secrétaire chargé des finances de leur parti. Ce dernier est suspecté d'avoir fomenté, le 19 février, une tentative d'assassinat contre le président de la Cour suprême. »JA constate que « le flou demeure à Ndjamena, ou les réseaux téléphonique et internet sont largement perturbés ». Tchad infos observe de son côté« une reprise timide des activités » dans la capitale.

Des tirs sporadiques ont été entendus mercredi à N'Djamena près du siège du Parti socialiste sans frontières (PSF), accusé par le gouvernement d'une attaque qui a visé la nuit précédente des bureaux des puissants services de renseignement, faisant "plusieurs morts". 

Secrets To Overcoming Pain and Aging - PSF Framework Click Here for a FREE 15 min Zoom Consultation With Brad: The podcast interview between Brad Williams of Over 40 Fitness Hacks and Megan Dahlman from the Self Care Simplified podcast delves into strategies for staying youthful and pain-free as we age, particularly focusing on the needs of the over 40 audience. Brad emphasizes the importance of quality of life over quantity, expressing the desire to address various health issues commonly faced by individuals in this demographic. Megan challenges the notion that pain and physical decline are inevitable with aging, highlighting that much of the discomfort stems from neglecting proper body usage and failing to maintain physical wellness. She introduces the PSF framework—Posture, Strength, and Flexibility—as key components to address when experiencing pain or stiffness. Megan also touches on osteoarthritis, stressing that it's not an inevitable consequence of aging but rather a result of joint dysfunction. The discussion expands to include the role of inflammation, diet, and repetitive movements in exacerbating physical discomfort. Megan underscores the importance of identifying the mechanical and chemical aspects of pain and suggests working with trainers to understand optimal joint function. Brad shares his own experiences with back problems and emphasizes the significance of hip flexibility and lumbar spine stability. In essence, the conversation advocates for a holistic approach to pain management and wellness, emphasizing the importance of understanding how the body functions and addressing issues at their root causes rather than merely treating symptoms. Through education, awareness, and proactive lifestyle adjustments, individuals can significantly improve their quality of life as they age. If you're interested in online personal training or being a guest on my podcast, "Over 40 Fitness Hacks," you can reach me at brad@over40fitnesshacks.com or visit my website at: www.Over40FitnessHacks.com Additionally, check out my Yelp reviews for my local business, Evolve Gym in Huntington Beach, at https://bit.ly/3GCKRzV

Les journalistes et experts de RFI répondent aux questions des auditeurs sur le ralliement Saleh Déby Itno à l'opposition, sur le projet du Royaume-Uni d'expulser les migrants vers le Rwanda et sur un joueur congolais sanctionné par la Fédération rwandaise de Football. Mali : polémique autour d'un fichier de recensement  Selon les autorités de transition, un collectif de hackers maliens a récupéré les données du recensement administratif. Comment ont-ils procédé alors que ces données étaient en possession d'une société française ? Les élections vont-elles pouvoir être organisées dorénavant ? Avec David Baché, journaliste au service Afrique de RFI. Tchad : Saleh Déby Itno rejoint un parti d'opposition  L'oncle du président de la transition, Saleh Déby Itno, a annoncé rejoindre le Parti socialiste sans frontières, dirigé par l'opposant Yaya Dillo. Quelles sont ses motivations ? Pourrait-il être le candidat du PSF à la présidentielle ?  Avec Esdras Ndikumana, journaliste au service Afrique de RFI.Royaume-Uni – Rwanda : le projet d'expulsion des migrants à nouveau contesté  Une commission parlementaire britannique a critiqué le projet de loi visant à expulser au Rwanda les demandeurs d'asile. Face à ce nouvel obstacle, le projet pourrait-il être abandonné ? Le gouvernement britannique pourrait-il se tourner vers un autre pays ? Avec Caroline Renaux, journaliste au service Web de RFI. Retrouvez son article complet sur l'externalisation des demandeurs d'asile en Europe. Foot : un joueur congolais sanctionné par la fédération rwandaise Au Rwanda, l'attaquant congolais Héritier Luvumbu a été suspendu six mois pour avoir imité le geste de la sélection congolaise dénonçant « l'inaction » de la communauté internationale face aux crimes commis dans l'est de la RDC. Comment expliquer une sanction aussi lourde ? Pourrait-il rentrer dans son pays pour sa sécurité ?  Avec Lucie Mouillaud, correspondante de RFI à Kigali. 

On this episode of The Bullpen James Roy and Tom recap the Texans @ Ravens playoff matchup. As always, thanks for watching. You can find my socials and PSF link here: https://lnk.bio/n1texansfan Learn more about your ad choices. Visit megaphone.fm/adchoices

On this episode of The Bullpen James Roy and Tom preview the Texans @ Ravens playoff matchup. As always, thanks for watching. You can find my socials and PSF link here: https://lnk.bio/n1texansfan Learn more about your ad choices. Visit megaphone.fm/adchoices

On this episode of The Bullpen James Roy and Tom recap the Texans vs. Browns playoff matchup. As always, thanks for watching. You can find my socials and PSF link here: https://lnk.bio/n1texansfan Learn more about your ad choices. Visit megaphone.fm/adchoices

Topics covered in this episode: Python 3.13 gets a JIT UniDep - Unified Conda and Pip Dependency Management Don't Start Pull Requests from Your Main Branch instld: The simplest package management Extras Joke Watch on YouTube About the show Sponsored by us! Support our work through: Our courses at Talk Python Training The Complete pytest Course Patreon Supporters Connect with the hosts Michael: @mkennedy@fosstodon.org Brian: @brianokken@fosstodon.org Show: @pythonbytes@fosstodon.org Join us on YouTube at pythonbytes.fm/live to be part of the audience. Usually Tuesdays at 11am PT. Older video versions available there too. Brian #1: Python 3.13 gets a JIT Anthony Shaw Great article that walks through JIT concepts with a small example as if you were writing a parser in Python instead of C. Covers What is a JIT? What is a copy-and-patch JIT? and Why? How does the Python JIT work? Is it faster? This is a building block to future improvements Michael #2: UniDep - Unified Conda and Pip Dependency Management

On this episode of The Bullpen James Roy and Tom recap the Texans @ Colts matchup. As always, thanks for watching. You can find my socials and PSF link here: https://lnk.bio/n1texansfan Learn more about your ad choices. Visit megaphone.fm/adchoices

On this episode of The Bullpen James Roy and Tom preview the Texans @ Colts matchup. As always, thanks for watching. You can find my socials and PSF link here: https://lnk.bio/n1texansfan Learn more about your ad choices. Visit megaphone.fm/adchoices

Topics covered in this episode: * Hatch v1.8* svcs: A Flexible Service Locator for Python Steering Council 2024 Term Election Results Python protocols. When to use them in your projects to abstract and decoupling Extras Joke Watch on YouTube About the show Sponsored by us! Support our work through: Our courses at Talk Python Training The Complete pytest Course Patreon Supporters Connect with the hosts Michael: @mkennedy@fosstodon.org Brian: @brianokken@fosstodon.org Show: @pythonbytes@fosstodon.org Join us on YouTube at pythonbytes.fm/live to be part of the audience. Usually Tuesdays at 11am PT. Older video versions available there too. Michael #1: Hatch v1.8 Hatch now manages installing Python for you. Hatch can build .app and .exe stand-alone binaries for you The macOS ones are signed (signed!) Discussion here Brian #2: svcs : A Flexible Service Locator for Python Hynek A library to help structure and test Python web applications. “svcs (pronounced services) is a dependency container* for Python. It gives you a central place to register factories for types/interfaces and then imperatively acquire instances of those types with automatic cleanup* and **health checks.” “Benefits: Eliminates tons of repetitive boilerplate code, unifies acquisition* and cleanups of services, provides full static type safety for them, simplifies testing through loose coupling, improves live introspection and monitoring* with **health checks.” Hynek has started a YouTube channel, and is starting with an explanation of svcs. Yes, Hynek, we want more videos. I like that it's not a beginner level. My request for future videos: just past beginner, and also intermediate level. There are plenty of basics videos out there, not as many filling the gaps between beginner and production. Michael #3: Steering Council 2024 Term Election Results The 2024 Term Python Steering Council is: Pablo Galindo Salgado Gregory P. Smith Emily Morehouse Barry Warsaw Thomas Wouters Full results are available in PEP 8105 . How do you become a candidate? Candidates must be nominated by a core team member. If the candidate is a core team member, they may nominate themselves. Brian #4: Python protocols. When to use them in your projects to abstract and decoupling Carlos Vecina “Protocols are an alternative (or a complement) to inheritance, abstract classes and Mixins.” Understanding interactions between ABC, MixIns and Protocols in Python With examples Extras Brian: Donations. It's a decent time of the year to donate to projects that help you Python Software Foundation Django Software Foundation Python Bytes Also, look for “Sponsor this project” links in GitHub for projects you depend on. Michael: Mastodon guidelines (mine): If you have a picture and description, I'll probably follow you back If you have posts that seem relevant +1 If you have a verified webpage +1 If your account is private, won't. I don't understand really since private group messages already exist and the profile itself is public. Speaking of Mastodon. I had a productive conversation with the PSF and others around masks and conferences. Dropbox spooks users by sending data to OpenAI for AI search features There was a comment in the above article to the effect of “Once you give your data to a third party (even trusted like Dropbox), you no longer control that data.” That sent me searching and thinking… sync.com? proton drive (discount code)? nextcloud? filen.io? icedrive.net? ownCloud's recent CVE makes me a bit nervous of self-hosted options. Either way, Cryptomator is very interesting. Beyond privacy, this got me thinking, just how many hours of dev time have been diverted to add mediocre-at-best AI features to everything? I'm doing a big digital decluttering and have lots to say on that soon. Not submitting my talks to PyCascades this year. But I did submit 3 talks to PyCon US.

Topics covered in this episode: A Python/Django Advent calendar Dropbase helps you build internal web apps with Python Real-world match/case Extra, extra, extra, so many extras! Extras Joke Watch on YouTube About the show Sponsored by us! Support our work through: Our courses at Talk Python Training The Complete pytest Course Patreon Supporters Connect with the hosts Michael: @mkennedy@fosstodon.org Brian: @brianokken@fosstodon.org Show: @pythonbytes@fosstodon.org Join us on YouTube at pythonbytes.fm/live to be part of the audience. Usually Tuesdays at 11am PT. Older video versions available there too. Brian #1: A Python/Django Advent calendar James Bennett's take on an Advent Calendar “I'm going to try to publish one short blog post each day of Advent 2023, each covering a small but hopefully useful tip or bit of information for Python and/or Django developers” First post also discusses using enums A couple cool testing posts Don't mock Python's HTTPX I didn't know HTTPX had built in transport mocking, very cool Test your documentation doctest discussion Michael #2: Dropbase helps you build internal web apps with Python Build fullstack web apps for your internal teams. Import existing Python scripts Quickly layer UIs and granular permissions on top. Turn any SQL SELECT into an admin panel with Smart Tables. Watch the video for the zen of it. Freemium model Brian #3: Real-world match/case Ned Batchelder Structural pattern matching example taken from a GitHub bot Matching nested dictionaries, pulling out bits of data The examples of not just matching but using case [structure] if [test on component] are neat. Michael #4: Extra, extra, extra, so many extras! WAY better DNS with Bunny.net DNS Terminal Secrets essay Meet the Supporting Developer in Residence (via Pycoders) Songs in Python code BohemianRhapsody.py MoneyForNothing.py PyCascades 2024 Project names blocked on PyPI to avoid name collision for downstream free-threaded Python distributions An Open Letter to the Python Software Foundation PSF's official mission https://discuss.python.org/t/python-3-12-1-now-available/40603 https://discuss.python.org/t/python-3-11-7-is-available/40778 Obfuscated Python winning (via Johannes Lippmann) Extras Brian: Python for VSCode, Dec 2023 release, rolls out better test discovery to everyone. Forcing pip to use virtualenv Advent of Code Joke: Too many open tabs

Dr. Noelle Larson from Mayo Clinic joins the show to discuss her recent research.  We discuss pearls and pitfalls of RCTs in orthopedics when discussing her famed Minimize Implants Maximize Outcomes study. We discuss new ways for eliciting patient and family surgery preferences with regards to VBT vs. PSF choices. We also touch on the evolving role of AI in pediatric orthopedics and enabling technologies such as navigation-assisted surgery. Highlights from the lightning round include long-term Dega osteotomy outcomes and some impressive results from Halo-Pelvic traction for severe spine deformities. Your hosts are Craig Louer from Vanderbilt, Carter Clement from Children's Hospital of New Orleans, and Josh Holt from University of Iowa. Music by A. A. Alto.   Nov 2023 Show Notes – Noelle Larson Main Event The Effect of Implant Density on Adolescent Idiopathic Scoliosis Fusion: Results of the Minimize Implants Maximize Outcomes Randomized Clinical Trial. The Journal of Bone and Joint Surgery ():10.2106/JBJS.23.00178, November 16, 2023. | Larson, A. Noelle MD1,a,*; Polly, David W. MD2,*; Sponseller, Paul D. MD3; Kelly, Michael P. MD, MSc4; Richards, B. Stephens MD5; Garg, Sumeet MD6; Parent, Stefan MD, PhD7; Shah, Suken A. MD8; Weinstein, Stuart L. MD9; Crawford, Charles H. MD10; Sanders, James O. MD11; Blakemore, Laurel C. MD12; Oetgen, Matthew E. MD13; Fletcher, Nicholas D. MD14; Kremers, Walter K. PhD15; Marks, Michelle C. PT, MA16; Brearley, Ann M. PhD17; Aubin, Carl-Eric PhD18; Sucato, Daniel J. MD, MS5; Labelle, Hubert MD7; Erickson, Mark A. MD6;  the Minimize Implants Maximize Outcomes Study Group†   Non-Fusion Versus Fusion Surgery in Pediatric Idiopathic Scoliosis: What Trade-Offs in Outcomes Are Acceptable for the Patient and Family? A Noelle Larson, Michelle Claire Marks, Juan Marcos Gonzalez Sepulveda, Peter O Newton, Vincent J Devlin, Raquel Peat, Michelle E Tarver, Olufemi Babalola, Allen L Chen, David Gebben, Patrick Cahill, Suken Shah, Amer Samdani, Keith Bachmann, Baron Lonner Journal of Bone and Joint Surgery. American Volume 2023 November 10   Radiation exposure in navigated techniques for AIS: is there a difference between pre-operative CT and intraoperative CT? Mikaela H Sullivan, Lifeng Yu, Beth A Schueler, Ahmad Nassr, Julie Guerin, Todd A Milbrandt, A Noelle Larson Spine Deformity 2023 October 24   Settings on the intraoperative scanner typically were 80 kV, 20 mA, and 20 mAs, but occasionally 70 kV, 16 mA, and 64 mAs for patients < 60 kgs.   Automated Measurements of Interscrew Angles in Vertebral Body Tethering Patients with Deep Learning. Kellen L Mulford, Christina Regan, Charles P Nolte, Zachariah W Pinter, Todd A Milbrandt, A Noelle Larson Spine Journal : Official Journal of the North American Spine Society 2023 September 28   Lightning Round   Twelve to Twenty-year Follow-up of Dega Acetabuloplasty in Patients With Developmental Dysplasia of the Hip: Is it as Effective as Expected? Murat Danişman, Gökay Dursun, İsmail Aykut Koçyiğit, Caglar Yilgor, Mehmet Cemalettin Aksoy Journal of Pediatric Orthopedics 2023 November 2   Evaluation of Pulmonary Function After Halo-Pelvic Traction for Severe and Rigid Kyphoscoliosis Utilizing CT with 3D Reconstruction. Lijin Zhou, Hanwen Zhang, Honghao Yang, Zhangfu Li, Chaofan Han, Yiqi Zhang, Yong Hai Journal of Bone and Joint Surgery. American Volume 2023 September 22

Its Browns Week!  The AFC North kitchen is heating up as the Steelers travel to the mistake by the lake to take on the Brownies.  join JT, TA, Freight Train and Shayne Man on their thoughts and predictions on the game.  Shayne appears regularly on The Still Curtain Podcast on YouTube as well as the PSF.app Steelers Fans NFL channel. Chat with us on YouTube, Facebook, Twitter, and now the hottest interactive sports app going, Pro Sports Fans, for the best way to follow  your Pittsburgh Steelers!  Learn more at Https://psf.app Download the app today, create your user profile and join the Steelers Fans group.Promotional consideration also provided by Camo, by Reincubate.  Camo enables the camera you already own to produce incredible video for meetings, streaming, or recording. Start creating great video for free today at Reincubate.com/camo/Stay tuned and listen in every Monday and Thursday during the season!Watch our video podcast versions on our YouTube, Rumble or Facebook (check out our former player episodes too!)Please like and follow and share when you can.  We appreciate your listen!Home Base is  www.SteelersRealm.comFacebook Group  Steeler Nation Local #724 Support the show

Topics covered in this episode: PyCon 2024 is up? Ruff formatter is production ready gil--; Why is the Django Admin “Ugly”? Extras Joke Watch on YouTube About the show Sponsored by Scout APM Connect with the hosts Michael: @mkennedy@fosstodon.org Brian: @brianokken@fosstodon.org Show: @pythonbytes@fosstodon.org Join us on YouTube at pythonbytes.fm/live to be part of the audience. Usually Tuesdays at 11am PT. Older video versions available there too. Michael #1: PyCon 2024 is up? May 15 - May 23, 2024 - Pittsburgh, Pennsylvania Conference breakdown: Tutorials: May 15 - 16, 2024 Main Conference and Online: May 17 - 19, 2024 Job Fair: May 19, 2024 Sprints: May 20 - May 23, 2024 Tickets aren't on sale yet Unfortunately, I'm not going (see health and safety guidelines) Attendance numbers over time on Wikipedia Brian #2: Ruff formatter is production ready We reported the alpha release in September It's fast, 30x faster than Black Provides >99.9% compatibility with Black, with a list of known deviations More configurable Bundled with ruff, ruff format Still in Beta, but considered production-ready Integration extensions for VSCode and PyCharm Michael #3: gil--; The Python Steering Council has now formally accepted PEP 703 ("Making the Global Interpreter Lock Optional in CPython") The global interpreter lock will remain the default for CPython builds and python.org downloads. A new build configuration flag, --disable-gil will be added to the configure script that will build CPython with support for running without the global interpreter lock. "In short, the SC accepts PEP 703, but with clear provisio: that the rollout be gradual and break as little as possible, that we can roll back any changes that turn out to be too disruptive – which includes potentially rolling back all of PEP 703 entirely if necessary (however unlikely or undesirable we expect that to be)." Removing the global interpreter lock requires substantial changes to CPython internals, but relatively few changes to the public Python and C APIs. The implementation changes can be grouped into the following four categories: Reference counting Memory management Container thread-safety Locking and atomic APIs Brian #4: Why is the Django Admin “Ugly”? Vince Salvino Some great quotes from the article: "The Django admin is not ugly, rather, no effort was made to make it a beautiful end-user tool.” - Ken Whitesell “The admin's recommended use is limited to an organization's internal management tool. It's not intended for building your entire front end around.” - Django docs “The Django admin was built for Phil.” - Jacob Kaplan-Moss “Even in the 0.9x days we used to have a image that said “Admin: it's not your app”.” - Curtis Maloney As Curtis put it, “encouraging people to build their own management interface, and treat admin as a DB admin tool, has saved a lot of people pain... the effort to customise it grows far faster than the payoffs.” Extras Brian: Local Conferences: Big Potential Michael: Data Science Jumpstart with 10 Projects course is out! PSF is X-ed out (or are they?) GPT4All is pretty excellent Fosstodon invites from us (expires Nov 7 2023) Joke: Searching YouTube for bug fixes

Do you worry about your developer / data science supply chain safety? All the packages for the Python ecosystem are much of what makes Python awesome. But the are also a bit of an open door to your code and machine. Luckily the PSF is taking this seriously and hired Mike Fiedler as the full time PyPI Safety & Security Engineer (not to be confused with the Security Developer in Residence staffed by Seth Michael Larson). Mike is here to give us the state of the PyPI security and plans for the future. Links from the show Mike on Twitter: @mikefiedler Mike on Mastodon: @miketheman@hachyderm.io Supply Chain examples SolarWinds: csoonline.com XcodeGhost: wikipedia.org Google Ad Malware: medium.com PyPI: pypi.org OWASP Top 10: owasp.org Trusted Publishers: docs.pypi.org libraries.io: libraries.io GitHub Full 2FA: github.blog Mike's Latest Blog Post: blog.pypi.org pprintpp package: github.com ICDiff: github.com Watch this episode on YouTube: youtube.com Episode transcripts: talkpython.fm --- Stay in touch with us --- Subscribe to us on YouTube: youtube.com Follow Talk Python on Mastodon: talkpython Follow Michael on Mastodon: mkennedy Sponsors Sentry Error Monitoring, Code TALKPYTHON Talk Python Training