Podcasts about mers cov

So, let's talk about HKU5—a coronavirus variant that's just one mutation away from potentially infecting humans. Should we be worried? Could this be the next pandemic threat? Tune in to this episode to find out! We've seen how fast viruses can spread once they make the jump to humans, and with scientists discovering HKU5, this topic has sparked significant concern in the scientific community and even spooked the financial markets—causing unnecessary panic, financial market fluctuations, and public uncertainty. But should we really be alarmed? Or is this another case of fear outpacing the facts? In this episode, we'll answer all that as we discuss everything you need to know about HKU5. From its potential to mutate, why experts are concerned, to whether or not it could trigger another pandemic—we'll cover all that in today's podcast. So, if you want to know whether or not this could be the next global health crisis, tune in to this episode as we separate fear from reality and prepare without the panic. Why you need to check this episode: Learn about the characteristics of the HKU5 virus and how it compares to other coronaviruses like MERS-CoV; Discover why HKU5 has the scientists' attention and why financial markets have reacted to this news; Understand the role of mutations in virus transmission and know whether this strain poses a real threat to humans; and Differentiate scientific caution from media-driven panic, and learn what we can do to stay prepared and informed of HKU5's risks. “So, there are some things we know and some things we don't know about this HKU5 variant. What I can tell you right now [is] no, we're not headed to a new pandemic, [and] yes, I do think it was an overreaction, especially from these financial markets to sell off and almost mini-crash just because they hear of a new coronavirus—a very big overreaction [that] did not need to occur, especially when you're inclined to actually read the data…So again, should you be worried? No, but definitely be prepared for any news to come.” – Dr. Berry Pierre Notable Quotes: “This hasn't happened yet, [but] theoretically, from a lab perspective…these mutations are possible that can now make this HKU5 variant that primarily affects bats, cattle, and sheep to now jump to human cells…It has not happened yet, but there is a concern there.” – Dr. Berry Pierre “No one wants to be caught off-guard to a new variant, to a new virus—because we saw what happened when we were caught off-guard with the first one.” – Dr. Berry Pierre “We're still dealing with the coronavirus now, we're still dealing with variants now, [and] people are still dying now, even though you're not seeing it on your TV. It's off the TV—they made sure of that…So, you're not going to get the necessary fanfare…but trust me, we're still seeing these patients in the hospital [and] people are still dying in the hospital from it.”– Dr. Berry Pierre “As we continue to move in this post-pandemic world, understand that we can do some things better than what we did the first go around. We can educate better. We can learn better. We can try to break down any misconceptions better. We can do a lot of things better, especially for those who are fortunate enough to still be alive after the pandemic.” – Dr. Berry Pierre Sign up at www.listentodrberry.com  to join the mailing list. Remember to subscribe to the podcast and share the episode with a friend or family member. Listen on Apple Podcast, Google Play, Stitcher, Soundcloud, iHeartRadio, and Spotify Resources: The Article that Dr. Berry Read Watch Our Previous Episodes Discussing the Coronavirus Below: Answering YouTube's Pressing Covid-19 Questions Why Covid-19 and the Flu are NOT the Same Thing Are COVID Cases Rising Again What is Long COVID Doctor Reacts to Monkeypox Vs Covid-19 Debate Doctor Reacts to Covid-19, Omicron Variant, & School Shutdowns What is the Covid-19 Omicron BA.5 variant 4 Million Cases Later with COVID-19 (coronavirus update)

In this episode of Transmission Interrupted, we continue our Pathogens in Pop Culture series with an intriguing dive into the world of special pathogens in literature. Dr. Caitlin Rivers, senior scholar at the Johns Hopkins Center for Health Security, joins us to examine the science behind the use of special pathogens in popular literature. We'll also examine the importance of adhering to reality or fictionalization when writing about pathogens and the power of storytelling in promoting public health practices.GuestCaitlin Rivers, PhD, MPHDr. Rivers is a Senior Scholar at the Johns Hopkins Center for Health Security and an Assistant Professor in the Department of Environmental Health and Engineering at the Johns Hopkins Bloomberg School of Public Health. She is an epidemiologist specializing in preparedness and response for epidemics, pandemics, and deliberately occurring events. Dr. Rivers recently returned from an appointment as founding associate director of the Center for Forecasting and Outbreak Analytics at the Centers for Disease Control and Prevention (CDC).Dr. Rivers has testified in front of the United States Congress on several occasions and is a frequent advisor to senior leaders at the state and federal levels. She served on the Biden-Harris Presidential Transition Team working on COVID-19 policies. Her writing has been published in the Washington Post, Wall Street Journal, New York Times, and USA Today.During the COVID-19 pandemic, Dr. Rivers participated as author or contributor in influential reports that are guiding the US pandemic response, including National Coronavirus Response: A Roadmap to Reopening and Public Health Principles for a Phased Reopening During COVID-19: Guidance for Governors, the latter of which was used by the National Governors Association, the state of Maryland, and Washington, DC, to guide reopening plans.Prior to joining the Center in 2017, Dr. Rivers worked as an epidemiologist for the US Army Public Health Center as a Department of Defense Science, Mathematics, and Research for Transformation Scholar. She also participated in a National Science and Technology Council Pandemic Prediction and Forecasting Science and Technology working group. Dr. Rivers serves as an Associate Editor of the journal Health Security.Dr. Rivers has been awarded the Johns Hopkins Bloomberg School of Public Health Faculty Award for Excellence in US Public Health Practice; the Department of the Army Achievement Medal for Civilian Service; and a Department of Defense Science, Engineering, Mathematics and Research Transformation Scholarship. In 2015, she earned a PhD in genetics, bioinformatics, and computational biology from Virginia Tech. Her doctoral research focused on computational epidemiology, specifically modeling emerging infectious diseases such as avian influenza A (H7N9), Middle East respiratory syndrome coronavirus (MERS-CoV), and Ebola virus disease for public health support using nontraditional, publicly available sources of data. Dr. Rivers received an MPH with a concentration in infectious disease from Virginia Tech in 2013 and a BA in anthropology from the University of New Hampshire in 2011.HostsLauren Sauer, MScLauren is an Associate Professor in the College of Public Health, Department of Environmental, Agricultural, and Occupational Health, at the University of Nebraska Medical Center and Core Faculty of the UNMC Global Center for Health Security. She is an Adjunct Associate Professor of Emergency Medicine in the Johns Hopkins...

Tim, Ian, Hannah Claire, & Kellen join Dave Landau to discuss a body being found on Obama's property, Twitter rebranding to "X", a new fatal disease called MERS-CoV, and the new woke "reimagining" of Snow White. Learn more about your ad choices. Visit megaphone.fm/adchoices

On episode #18 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 12/9/22 – 12/21/22. Hosts: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of Puscast! Links for this episode Human Rabies in Texas, 2021 (CDC) Human rabies despite post-exposure prophylaxis (The Lancet) The Qatar FIFA World Cup 2022 and camel pageant championships increase risk of MERS-CoV transmission and global spread (The Lancet) An update on eukaryotic viruses revived from ancient permafrost (bioRx) Colistin monotherapy vs combination therapy for carbapenem-resistant organisms (NEJM) Outcomes of Ceftriaxone vs antistaphylococcal Penicillins or Cefazolin for definitive therapy of Methicillin-susceptible Staphylococcus aureus bacteremia (OFID) Salmonella enteritidis cardiovascular implantable electronic device infection (OFID) Evaluation of serotonin syndrome with Linezolid and serotonergic agents at an academic medical center (OFID) Preemptive antifungal therapy for the prevention of invasive candidiasis following gastrointestinal surgery for Intra-abdominal infections (CID) Risk factors and outcomes of invasive aspergillosis in kidney transplant recipients (CID) Predictive performance of gram staining of catheter tips for Candida catheter-related bloodstream infections (OFID) Integrative genetic manipulation of Plasmodium cynomolgireveals multidrug resistance-(JID) Clinical characteristics of patients with calcified parenchymal neurocysticercosis and perilesional edema (OFID) Impact of sequestration on artemisinin-induced parasite clearance in Plasmodium falciparum malaria in Africa (CID) Factors contributing to delayed academic advancement of women in infectious diseases (OFID) Characterization of problematic alcohol use among physicians (JAMA) Alpha-gal syndrome in the ID clinic (OFID) Efficacy and safety of Azithromycin vs placebo to treat lower respiratory tract infections associated with low procalcitonin (The Lancet) Music is by Ronald Jenkees

TWiV reviews eukaryotic viruses recovered from ancient permafrost, a mistake made by scientists on Omicron origins, and close relatives of MERS-CoV from bats that bind ACE2 for entry into cells. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support MicrobeTV with a Spike t-shirt (Vaccinated.us) with promo code MicrobeTV Positions with the Mosquito and Vector Control Division in Harris County Public Health (one and two) Ancient eukaryotic viruses from permafrost (bioRxiv) We made a mistake (Science) Bat MERS-like CoV bind ACE2 (Nature) Letters read on TWiV 968 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Alto Saxophone: Paul Desmond/Cannonball Adderley/Charlie Parker/Randal Despommier: Paul Desmond: Signature album: Paul Desmond:The Complete RCA Victor Recordings (1961-1965). Signature song: Take Five (Dave Brubeck Quartet). Cannonball Adderley: Signature album: The Cannonball Adderley Quintet: Mercy, Mercy, Mercy. Signature song: Mercy, Mercy, Mercy. Charlie Parker (Bird): played in many groups: Signature album: Dizzy Gillespie and His Allstars. Signature song: A Night In Tunisia; Randal Despommier: Signature album: A Midsummer Odyssey. Signature song: I Hope It's Spring For You. Brianne – How a See-Through Frog Hides its Red Blood from Predators (also covered in The Atlantic) Rich – Mindfulness in Plain English by Ven. Henepola Gunaratana Vincent – Unveiling skin macrophage dynamics explains both tattoo persistence and strenuous removal Listener Picks Rona – WKCR, FM 89.9 Columbia‘s radio station Alan – XKCD Proxy Variable Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

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Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.17.516978v1?rss=1 Authors: Liu, P., RUAN, D., Ye, Z.-W., Yuan, S., Li, Z., Zhang, W., Ong, C. P., Tang, K., Guo, J., Xuan, Y., Tam, T. T. K. K., Huang, Y., Zhang, Q., Lee, C.-L., Chiu, P. C. N., Liu, F., Jin, D.-Y. Abstract: The ongoing and devastating pandemic of coronavirus disease 2019 (COVID-19) has led to a global public health crisis. COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and can potentially pose a serious risk to maternal and neonatal health. Cases of abnormal pregnancy and vertical transmission of SARS-CoV-2 from mother to foetus have been reported but no firm conclusions are drawn. Trophoblasts are the major constituents of the placenta to protect and nourish the developing foetus. However, direct in vivo investigation of trophoblast susceptibility to SARS-CoV-2 and of COVID-19 and pregnancy is challenging. Here we report that human early syncytiotrophoblasts (eSTBs) are highly susceptible to SARS-CoV-2 infection in an angiotensin-converting enzyme 2 (ACE2)-dependent manner. From human expanded potential stem cells (hEPSCs), we derived bona fide trophoblast stem cells (TSCs) that resembled those originated from the blastocyst and the placenta in generating functional syncytiotrophoblasts (STBs) and extravillus trophoblasts (EVTs) and in low expression of HLA-A/B and amniotic epithelial (AME) cell signature. The EPSC-TSCs and their derivative trophoblasts including trophoblast organoids could be infected by SARS-CoV-2. Remarkably, eSTBs were highly susceptible to SARS-CoV-2. They expressed high levels of ACE2 and produced substantially higher amounts of virion than Vero E6 cells which are widely used in SARS-CoV-2 research and vaccine production. These findings provide experimental evidence for the clinical observations that opportunistic SARS-CoV-2 infection during pregnancy can occur. At low concentrations, two well characterized antivirals, remdesivir and GC376, effectively eliminated infection of eSTBs by SARS-CoV-2 and middle east respiratory syndrome-related coronavirus (MERS-CoV), and rescued their developmental arrest caused by the virus infection. Several human cell lines have been used in coronavirus research. However, they suffer from genetic and/or innate immune defects and have some of the long-standing technical challenges such as cell transfection and genetic manipulation. In contrast, hEPSCs are normal human stem cells that are robust in culture, genetically stable and permit efficient gene-editing. They can produce and supply large amounts of physiologically relevant normal and genome-edited human cells such as eSTBs for isolation, propagation and production of coronaviruses for basic research, antiviral drug tests and safety evaluation. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

In this week's episode of Clean Talk, Kathy Warye, Founder at Infection Prevention Partners, joins us to reveal her experiences as an Infection Preventionist and Healthcare Leader, and to explain how global community safety has come a very long way.Tune in to hear about a range of topics including:• Kathy Warye's professional background and how she got to where she is today• About Infection Prevention Partners & The Importance of Elevating the Infection Preventionists' role• The Importance of Investing in Public Health Laboratories, Technologies, and Institutions• Kathy's APIC History & APIC's evolution to a Patient Safety Organization under her direction• Nationwide Prevalence Study on MRSA following Chicago Tribe article & the CDC's Bill Jardice's findings• HAI's & 2010 IP Evangelist – Kathy's story of achieving Zero HAI's a decade ago has evolved to the expectations of IPs today• Today's De-Prioritization of Patient Safety to Accommodate Labor & Resource Shortages in Healthcare Today• The rate of MERS-CoV on the Arabian Peninsula• Predictions For the Future? Will we see another Pandemic in our lifetime?Kathy Warye is the founder of Infection Prevention Partners, a consultancy committed to advancing strategic initiatives with industry, government and nonprofit organizations to address the elimination of preventable infection, worldwide.In 2010, she was named one of the “100 Most Powerful People in Healthcare” by Modern Healthcare Magazine. Ms. Warye also formerly held the position of CEO for the Association for Professionals in Infection Control and Epidemiology (APIC) from 2003-2010.

Stand Up is a daily podcast. I book,host,edit, post and promote new episodes with brilliant guests every week day. Please subscribe now for as little as 5$ and gain access to a community of almost 800 awesome, curious, kind, funny, brilliant, generous soul. sign up now and join us every Thursday night for a virtual happy hour. Now on to today's show notes Dr. Rasmussen is a virologist studying host responses to infection by combining classical virology with modern systems biology approaches. Her research objectives are to identify host response signatures predictive of infection severity or disease outcome and host pathways to target drug development or repurposing. She is particularly interested in viruses that are highly pathogenic, newly emergent or likely to emerge because of climate change, land development, or ecological disruption. Currently she is focused on SARS-CoV-2, as well as other emerging pathogens with the potential to profoundly impact global health, such as Ebola virus, MERS-CoV, influenza virus, and hemorrhagic fever viruses. She works closely with other faculty and affiliates within the GHSS on the Viral Emergence Research Initiative (the VERENA Consortium), where she leads the core virology team. Dr. Rasmussen has employed uses in vitro systems, animal models, and clinical specimens to study the relationship between host response and pathogenesis. She previously developed a  model of Ebola virus disease in a genetically diverse panel of mice, the Collaborative Cross (CC), leveraging the diversity of CC mouse disease phenotypes to study genetic and transcriptomic factors underlying disease severity in humans. She has applied this model to developing predictive signatures of disease outcome and infection and identify novel drug targets. She is currently evaluating CC mouse models towards investigation of sex-specific host responses to viral infection, as well as to investigate disease presentation in other viruses that pose a major threat to global public health, including SARS-CoV-2. Ultimately, these host response profiles can be used for translational or biodefense applications, such as diagnosing infection, predicting disease severity, informing vaccine design, and developing or repurposing host-targeted drugs to impair virus replication or reverse pathology.  Dr. Rasmussen has published numerous original research articles in the peer-reviewed literature and serves on the editorial board of Cell Reports and mSphere. In addition to her scientific work, she believes that engagement of the public is essential to successful public health initiatives and is an active and outspoken science communicator. She has written for Forbes, Foreign Affairs, Slate, the Guardian, and Leapsmag, and appeared many times in media outlets including the New York Times, the Washington Post, National Public Radio, ABC, NBC, CNN, CBC, and BBC. She is also an advocate for equitable and inclusive science, and serves on the NIH Advisory Committee to the Director's Working Group on Changing the Culture to End Sexual Harassment. Check out all things Jon Carroll Follow and Support Pete Coe Pete on YouTube Pete on Twitter Pete On Instagram Pete Personal FB page  

The World Health Organisation has revealed that a new coronavirus was discovered by Chinese scientists and may pose a threat to humans in the future. Researchers from Wuhan, China, where Covid-19 was first spotted in 2019, found this new virus amongst bats in South Africa. At the same time, they warned of its high death and transmission rate. According to experts, the NeoCoV virus is not new. It is associated with the MERS-CoV virus, in outbreaks in Middle Eastern countries in 2012 and 2015, and is similar to SARS-CoV-2, which causes Covid-19 in humans. Coronaviruses are a wide range of viruses that can cause a variety of diseases, ranging from the common cold to Severe Acute Respiratory Syndrome, SARS.

Bret and Heather and Ivermectin.  Oh my. IDSG returns from it's 17 year absence with a banger of an episode in which Daniel dishes out THE FUCKING TEA on Bret Weinstein & Heather Heying (again) and their irresponsible spreading (in hushed, reasonable voices) of potentially lethal conspiracy theories and bad science re Covid, Wuhan, vaccines, and Ivermectin.  Content Warnings. Podcast Notes: Please consider donating to help us make the show and stay independent.  Patrons get exclusive access to one full extra episode a month. Daniel's Patreon: https://www.patreon.com/danielharper Jack's Patreon: https://www.patreon.com/user?u=4196618 IDSG Twitter: https://twitter.com/idsgpod Daniel's Twitter: @danieleharper Jack's Twitter: @_Jack_Graham_ IDSG on Apple Podcasts: https://podcasts.apple.com/us/podcast/i-dont-speak-german/id1449848509?ls=1 Show Notes: Bret Weinstein Odysee Bret interviews Yuri Deigin. Yuri Deigin, Lab Made? SARS-CoV-2 Geneaology Through the Lens of Gain of Function Research Indeed, virologists, including the leader of coronavirus research at the Wuhan Institute of Virology, Shi Zhengli, have done many similar things in the past — both replacing the RBM in one type of virus by an RBM from another, or adding a new furin site that can provide a species-specific coronavirus with an ability to start using the same receptor (e.g. ACE2) in other species. In fact, Shi Zhengli's group was creating chimeric constructs as far back as 2007 and as recently as 2017, when they created a whole of 8 new chimeric coronaviruses with various RBMs. In 2019 such work was in full swing, as WIV was part of a $3.7 million NIH grant titled Understanding the Risk of Bat Coronavirus Emergence. Under its auspices, Shi Zhengli co-authored a 2019 paper that called for continued research into synthetic viruses and testing them in vitro and in vivo: Bret and Heather on Real Time with Bill Mahr on the Lab-Leak Hypothesis CLIP (Bret and Heather on BIll Maher Lab Leak) – starts at beginning of clip. Andersen, et al. The proximal origin of SARS-CoV-2 SARS-CoV-2 is the seventh coronavirus known to infect humans; SARS-CoV, MERS-CoV and SARS-CoV-2 can cause severe disease, whereas HKU1, NL63, OC43 and 229E are associated with mild symptoms6. Here we review what can be deduced about the origin of SARS-CoV-2 from comparative analysis of genomic data. We offer a perspective on the notable features of the SARS-CoV-2 genome and discuss scenarios by which they could have arisen. Our analyses clearly show that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus. Garry, Robert. [Early appearance of two distinct genomic lineages of SARS-CoV-2 in different Wuhan wildlife markets suggests SARS-CoV-2 has a natural origin](https://virological.org/t/early-appearance-of-two-distinct-genomic-lineages-of-sars-cov-2-in-different-wuhan-wildlife-markets-suggests-sars-cov-2-has-a-natural-origin/691 This Week in Virology 762: SARS-Cov-2 origins with Robert Garry CLIP (Two Covid Lineages in Wuhan Market) – Starts about 39:00 in TWIV762 potholer54, Did SARS-Cov-2 start in a Chinese Lab? potholer54, More “man-made” SARS-CoV-2 lab-leak malarky Scott Gavura, Science Based Medicine, “Ivermectin is the New Hydroxychloroquine” There has been interest in ivermectin since the early days of the COVID-19 pandemic, because it was observed that at high concentrations it had antiviral properties against the SARS-CoV-2 virus. However, there was an important red flag in that finding. A few weeks after the initial finding was published, a short paper appeared in the British Journal of Clinical Pharmacology that described the considerations for using ivermectin as an antiviral. While it acknowledged the antiviral properties of high concentrations of the drug in laboratory (in vitro) experiments, it noted that it would likely not be possible to achieve the same concentrations of the drug in the plasma of the blood, because the drug itself is tightly bound to blood proteins. Even giving 8.5 x the FDA-approved dose (1700mcg/kg) resulted in blood concentrations far below the dose identified that offered antiviral effects: [[Ivermectin-Cmax.png]] This Week in Virology 766: The Corona Project with David Fajgenbaum CORONA project 18:58, 46:32 “How To Save the World in Three Easy Steps” Clip “Ivermectin End the Pandemic” – starts around 3:30 Bret Weinstein, “COVID, Ivermectin, and the Crime of the Century - DarkHorse Podcast with Pierre Kory & Bret Weinstein” With Dr. Robert Malone (invented mRNA vaccine technology) and Mr. Steve Kirsch. Clip “Bret Doctors as Scientists from CotC” – Starts around 19:00 With Pierre Kory Science Based Medicine, Ivermectin is the new hydroxychloroquine, take 2 Last week, über-quack Joe Mercola published an article entitled “COVID, Ivermectin and the Crime of the Century“, naming it after an episode of Bret Weinstein's podcast. It features an interview with Dr. Pierre Kory, one of the most prominent proponents of ivermectin for COVID-19 by evolutionary biologist Bret Weinstein, who has become prominent as a COVID-19 contrarian and spreader of disinformation, particularly about the “lab leak theory” of SARS-CoV-2 origins and now likes to Tweet about “persecution” by Twitter: It also turns out that Dr. Pierre Kory is president of the Frontline COVID-19 Critical Care Alliance (FLCCC) and has testified before Congress. During that testimony, Dr. Kory claimed that ivermectin, used with other medicines such as vitamin C, zinc and melatonin, could “save hundreds of thousands of people,” and cited more than 20 studies. The narrative of Mercola's article is eerily similar to the narratives we heard about hydroxychloroquine a year ago, namely that ivermectin is a cheap, safe, and effective drug that “they” don't want you to know about that could have saved hundreds of thousands of lives if not for doctors' fetish for randomized clinical trials. Ivermectin is the new hydroxychloroquine, part three Before I move on to more of the ivermectin conspiracy theorists and potential reasons for them, I can't help but repeat what I've been saying all along about ivermectin. Combining preclinical studies that show antiviral activity against SARS-C0V-2, the coronavirus that causes COVID-19 in vitro (cell culture) but only at much higher concentrations of ivermectin than can be achieved with safe doses in the bloodstream with the equivocal clinical trial results lead to a conclusion that this drug almost certainly does not work to treat COVID-19. This is particularly likely given that the highest quality existing randomized controlled clinical trials of ivermectin are all basically negative. I note that when I discussed how poor the evidence for hydroxychloroquine for COVID-19 was, I routinely received criticism that I “wanted patients to die” and was “hoping” that the drug didn't work. I'm getting some of the same nonsense now that I've finally been prodded to write about ivermectin. Nothing could be further from the truth. Even though, now that there are safe and effective COVID-19 vaccines, the need for a cheap and effective drug that can treat COVID-19 is not as desperate as it was a year ago, it is still acute given how large swaths of the globe still do not have access to the vaccines. Moreover, now that Oxford University has added ivermectin to the protocol of its massive PRINCIPLE Trial of treatments for COVID-19, it is possible that there might turn out to be a benefit due to ivermectin in treating COVID-19, clearly just not as massive as claimed by advocates and conspiracy theorists. I'd be just fine with that, as I would have been overjoyed if hydroxychloroquine had been shown to be as effective as its advocates had claimed it was. It's just that, right now, the evidence is trending strongly in favor of the conclusion that ivermectin, like hydroxychloroquine before it, doesn't work against COVID-19 in humans. Gideon M-K; Health Nerd What this means is that, if you exclude some of the low-quality research on ivermectin, the paper goes from showing a massive benefit to no benefit at all. On top of this, there's an interesting point — even if you don't agree with these assessments, taking the only three studies that the authors of the meta-analysis considered to be at a “low risk of bias” (i.e. high-quality), you find that these high-quality studies have failed to find any benefit for ivermectin. In other words, while the conclusions the authors came to are very positive, the results section of the paper seems to show that the evidence for ivermectin might not be strong after all. The devil really is in the details with research like this. Jack Lawrence aka TimPoolClips Why Was a Major Study on Ivermectin for COVID-19 Just Retracted? Even if the paper's authors end up providing an innocent explanation for all this it would be puzzling why it took them so long to notice their error. Whether the final story is one of purposeful fabrication or a series of escalating mistakes involving training or test datasets, this research group has still screwed up in a big way. Although science trends towards self-correction, something is clearly broken in a system that can allow a study as full of problems as the Elgazzar paper to run unchallenged for seven months. Thousands of highly educated scientists, doctors, pharmacists, and at least four major medicines regulators missed a fraud so apparent that it might as well have come with a flashing neon sign. That this all happened amid an ongoing global health crisis of epic proportions is all the more terrifying. For those reading this article, its findings may serve as a wake-up call. For those who died after taking a medication now shown to be even more lacking in positive evidence, it's too late. Science has corrected, but at what cost? Ivermectin is the new hydoxychloroquine, take four Of course, as Meyerowitz-Katz observed, just the results of the study raised a lot of red flags. Elgazzar 2020, if you take the authors at their word, enrolled over 400 people with COVID-19 and 200 close personal contacts and allocated them either to ivermectin or placebo groups, reporting that ivermectin treatment decreased mortality from COVID-19 by a whopping 90%. As Meyerowitz-Katz observed, if this were true, that would make ivermectin the “most incredibly effective treatment ever to be discovered in modern medicine.” While as a physician I might quibble about that a bit (we do have treatments that are greater than 90% effective at eliminating the diseases or conditions that they treat, especially a number of vaccines), he is correct if you restricted this to antiviral drugs. If this study's results were accurate and generalizable, ivermectin would be the most most incredibly effective antiviral treatment ever to be discovered. That result alone should have raised a number of red flags, and it did among authors doing meta-analyses who were not ivermectin advocates from the BIRD Group or the FLCCC, which is why they excluded it from their analyses. Meilssa Davey at The Guardian Huge sttudy supporting ivermectin as Covid treatment withdrawn over ethical concerns A medical student in London, Jack Lawrence, was among the first to identify serious concerns about the paper, leading to the retraction. He first became aware of the Elgazzar preprint when it was assigned to him by one of his lecturers for an assignment that formed part of his master's degree. He found the introduction section of the paper appeared to have been almost entirely plagiarised. It appeared that the authors had run entire paragraphs from press releases and websites about ivermectin and Covid-19 through a thesaurus to change key words. “Humorously, this led to them changing ‘severe acute respiratory syndrome' to ‘extreme intense respiratory syndrome' on one occasion,” Lawrence said. The data also looked suspicious to Lawrence, with the raw data apparently contradicting the study protocol on several occasions. “The authors claimed to have done the study only on 18-80 year olds, but at least three patients in the dataset were under 18,” Lawrence said. Dark Horse 85: YouTube and The Truman Faux Medical Show CLIP “DH85 Save Three Kill Two” – Starts Around 50:00 Dark Horse 86: They've Got That Covered CLIP “DH86 Retraction” – Starts around 19:00 “Scientists quit journal board, protesting ‘grossly irresponsible' study claiming COVID-19 vaccines kill” Several reputed virologists and vaccinologists have resigned as editors of the journal Vaccines to protest its 24 June publication of a peer-reviewed article that misuses data to conclude that “for three deaths prevented by [COVID-19] vaccination, we have to accept two inflicted by vaccination.” Since Friday, at least six scientists have resigned positions as associate or section editors with Vaccines, including Florian Krammer, a virologist at the Icahn School of Medicine at Mount Sinai, and Katie Ewer, an immunologist at the Jenner Institute at the University of Oxford who was on the team that developed the Oxford-AstraZeneca COVID-19 vaccine. Their resignations were first reported by Retraction Watch. “The data has been misused because it makes the (incorrect) assumption that all deaths occurring post vaccination are caused by vaccination,” Ewer wrote in an email. “[And] it is now being used by anti-vaxxers and COVID-19-deniers as evidence that COVID-19 vaccines are not safe. [This] is grossly irresponsible, particularly for a journal specialising in vaccines.” The paper is a case of “garbage in, garbage out,” says Helen Petousis-Harris, a vaccinologist who directs the Vaccine Datalink and Research Group at the University of Auckland and who also resigned as a Vaccines editor after reading the paper. Diane Harper, an epidemiologist at the University of Michigan, Ann Arbor, who was founding editor-in-chief of Vaccines, also resigned, as did Paul Licciardi, an immunologist at Murdoch Children's Research Institute in Parkville, Australia, and Andrew Pekosz, a respiratory virologist at the Johns Hopkins University Bloomberg School of Public Health. Epoch Times, Dr. Bret Weinstein, “Perverse Incentives in the Vaccine Rollout and the Censhorship of Science” * Anna Merlan at Vic; two excellent summaries: 1. 'Why Is the Intellectual Dark Web Suddenly Hyping an Unproven COVID Treatment?' https://www.vice.com/en/article/wx5z5y/why-is-the-intellectual-dark-web-suddenly-hyping-an-unproven-covid-treatment 2. 'The Ivermectin Advocates' War Has Just Begun' https://www.vice.com/en/article/y3d5gv/ivermectin-covid-treatment-advocates-rogan-weinstein-hecker Jef Rouner at Houston Press on Bret https://www.houstonpress.com/news/a-possible-new-anti-vaccine-scam-is-on-the-rise-11591162 Decoding the Gurus on Bret & Heather and Ivermectin https://decoding-the-gurus.captivate.fm/episode/brett-heather-weinstein-why-are-they-suppressing-ivermectin-the-miracle-cure Bret platforms Geert Vanden Bossche https://www.youtube.com/watch?v=BNyAovuUxro&t=6s Vaxopedia on Geert Vanden Bossche https://vaxopedia.org/2021/03/14/who-is-geert-vanden-bossche/?fbclid=IwAR3u1myW15pERVxvcopv5NlWBr12QakfzVMHsoHHopLuJWKSUGfockqYhBo ZDoggMD on Geert Vanden Bossche https://www.youtube.com/watch?v=NEyQi__zTuo Potholer54 on Covid and vaccines etc https://www.youtube.com/playlist?list=PL82yk73N8eoWneZjR0wiidhGkAMOeIYAS QAnon Anonymous feat. scientist on 'Lab Leak' theory https://soundcloud.com/qanonanonymous/unlocked-premium-episode-129-lab-leak-hypothesis-feat-dr-alex-greninger Citations Needed Pod vaccine inequality https://citationsneeded.libsyn.com/size/5/?search=vaccine Clip from start; Charlie Kirk cites Bret to Tucker Carlson https://twitter.com/uberfeminist/status/1418033997398020102 Eiynah's panel on 'Mergegate' (feat. D. Harper) Part 1 https://soundcloud.com/politeconversations/panel-24-defending-new-atheism-maybe-just-dont-pt-1 Daniel's guest appearance on Decoding the Gurus https://decoding-the-gurus.captivate.fm/episode/special-episode-interview-with-daniel-harper-on-the-far-right-idw-criticism  

Merhaba, Şubat ayında AJEM’de Acil Hekimleri için yayınlanmış “COVID-19 in pregnancy and the puerperium: A review for emergency physicians​1​” makalesini, farklı bir kaç derleme​2–8​ ile toparlayarak ilginize sunuyorum, iyi okumalar… Gebeler  savunmasız bir popülasyondur ve klinisyenin hastalık ve hamilelik üzerindeki etkileri hakkında bilgi sahibi olması, tedavi planlaması ve hasta danışmanlığında önemlidir. Gebeler, şiddetli COVID-19 enfeksiyonu için yüksek riskli bir grup olarak kabul edilmektedir ve virüsün maternal ve perinatal sonuçlar üzerindeki potansiyel olumsuz etkileri endişe vericidir. Gebelikte solunum yolu hastalıkları ve diğer koronavirüslerin patofizyolojisi Hamilelikle ilişkili fizyolojik ve mekanik değişiklikler, genel olarak annenin enfeksiyonlara yatkınlığını arttırır. Gebelik, yarıalojenik fetüsün reddini önlemek için maternal bağışıklık sisteminde değişikliğe neden olan görece bir immün süprese durumudur. SARS-CoV-1, MERS-CoV veya SARS-CoV-2 enfeksiyonu nedeniyle hastaneye yatırılan hamile kadınların meta-analizi, asemptomatik olsa bile bu hastaların %90'ında, direk grafi veya bilgisayarlı tomografide pnömoni kanıtı göstermiştir. Bu meta-analiz aynı zamanda genel popülasyona kıyasla üç koronavirüs tanısı alan kadınlarda erken doğum, sezaryen doğum, yenidoğan yoğun bakım ünitesine (YYBÜ) yatış ve preeklampsi oranının arttığını da belirtmiştir. Gebelikte COVID-19'un klinik belirtileri Gebe olmayan bireylerde test, genellikle semptomlar veya ilgili bir temas öyküsü ile başvurduklarında yapılırken, gebeler genellikle hamilelik için takip veya COVID-19 ile ilgisi olmayan nedenler için başvururken test edilir. Genel popülasyona benzer şekilde, gebe hastalarda semptomatik COVID-19'un baskın özellikleri ateş, öksürük, nefes darlığı ve lenfopeni görülür. Üreme çağındaki gebe olmayan kadınlarla karşılaştırıldığında, COVID-19'u olan gebe kadınların ateş veya miyalji bildirme olasılığı daha düşüktür. Gebelikte sık görülen pek çok durum ateş, öksürük veya nefes darlığı ile ortaya çıkabilir ve COVID-19, preeklampsi ve pulmoner emboli dahil olmak üzere birçok riski artırır. Gebelikte COVID-19 semptomlarının ayırıcı tanısı geniştir ve PE, kardiyomiyopati, plevral veya perikardiyal efüzyon, preeklampsi, gestasyonel rinit, fizyolojik dispne ve viral/bakteriyel pnömoninin diğer etiyolojileri içerir. Belirti/semptomLaboratuvarGörüntülemeÖksürük Ateş Dispne Miyaljiler Anosmi /tad almada bozukluk Bulantı Kusma İshal↑/↓ Lökosit ↓ Lenfosit ↑ CRP ↑ LDH ↑ D-dimer* ↑ IL-6*Tek veya çift taraflı buzlu cam opasiteleri Plevral efüzyon* Yüksek D-dimer ve IL-6 kombinasyonu, kötü prognostik göstergedirGebelikte COVID-19'un Klinik Belirtileri Gebelikte COVID-19'un klinik seyri ve sonuçları Gebe kadınlarda COVID-19'un seyri ile ilgili veriler net değildir. Küçük uluslararası vaka serileri, gebe ve gebe olmayan kadınlarda benzer hastalık seyri olduğunu göstermektedir. Çoğu çalışma, kritik hastalığın gebe hastalarda nadir olduğunu, ancak genel popülasyonla karşılaştırıldığında biraz arttığını ileri sürmektedir. Bir çalışma, COVID-19 hastalığı teşhisi konan hamile kadınların yaklaşık % 90'ının doğum yaptırmaya gerek kalmadan iyileştiğini bildirmiştir. Semptomun başladığı trimesterla, hastalık sonuçlarını karşılaştıran çalışma çok azdır. Bu da düşük ve doğum sonrası komplikasyon oranlarını değerlendirmeyi zorlaştırmaktadır. Şiddetli veya kritik klinik durum, maternal ölüm, ölü doğum, neonatal ölüm ve YYBÜ’ne yatış dahil olmak üzere, kötü maternal ve neonatal sonuçların çoğundan sorumludur. COVID-19'lu gebe hastalar için tahmini mortalite, genel popülasyonla karşılaştırıldığında %0.6-2 iken, başvuru anında kritik hastalığı olanlar için COVID-19, ölümlerin büyük çoğunluğunu oluşturmaktadır. Üçüncü trimesterde yoğun bakıma(YB) ihtiyaç duyan gebe hastaların % 90'ından fazlasını bildiren bir çalışmada yoğun bakım başvuru oranı artan gebelik yaşı ile ilişkilendirilmiştir. Veriler,

As COVID vaccines become more accessible to the public, it's important to keep in mind the present dangers of other common respiratory illnesses. Transmission of these infections affects everyone, from Baby Boomers to Gen Zers, in various ways that could be fatal for some but a cough to others. Dr. Angela Rasmussen joins us to discuss testing and transmission regarding influenza, respiratory syncytial virus (RSV), and COVID-19. Hosted by: Silvia Quevedo, CAE About our Guest: Angela L. Rasmussen, Ph.D Angela L. Rasmussen, Ph.D. is a virologist currently affiliated with the Georgetown Center for Global Health Science and Security. In spring 2021, Dr. Rasmussen will also be starting a lab at the Vaccine and Infectious Disease Organization-International Vaccine Centre (VIDO-InterVac), a vaccine research institute at the University of Saskatchewan. Dr. Rasmussen is a member of the Verena Consortium, a multi-disciplinary, international effort to predict and study emerging viral pathogens. Dr. Rasmussen studies the role of the host response in emerging virus pathogenesis, with a particular interest in viruses that are or have the potential to be major threats to global health, such as influenza, dengue, Ebola, MERS-CoV, and SARS-CoV-2.

Esta noche analizamos la crisis sanitaria global en un momento de claro descenso de los casos. Una de cada tres provincias españolas ha salido ya de la alerta roja por nivel de contagios, lo que se traduce en un menor número de muertes. ¿A qué se debe el veloz descenso de la tercera ola? ¿Podríamos esperar un nuevo repunte en las próximas semanas? Para analizar estas y otras cuestiones nos acompañarán en directo el Dr. Miguel Ángel Pertierra, especialista en Otorrinolaringología y Cirugía, el Dr. Javier Cantón, virólogo especialista en coronavirus MERS-Cov, el Dr. Tomás Camacho, jefe de análisis clínicos de Laboratorios Vithas Lab, y nuestro compañero Pablo Fuente. Escucha el episodio completo en la app de iVoox, o descubre todo el catálogo de iVoox Originals

The COVID-19 pandemic continues to worsen by most objective measures. We're breaking records for cases, deaths, and hospitalizations on a regular basis, and many of our hospitals are operating at or near capacity. Further complicating the situation, scientists are tracking the “UK variant” that is more transmissible, and our vaccine distribution has fallen well short of expectations. Emergent problems in a deepening crisis, of course, make us vulnerable to knee-jerk reactions that distract us from the known path to getting the pandemic under control. On this episode, we're talking with virologist Dr. Angela Rasmussen about these emergent issues. She helps us to understand what they mean and puts them in context by pointing out the good things that are happening too. First and foremost, the vaccines are more efficacious than expected (i.e., around 95%). Second, the “UK variant”, while worrisome, has not evolved in any way that makes existing, non-pharmaceutical interventions less effective (e.g., masks, social-distancing, avoid crowds, clean high-touch surfaces, etc.).   The UK Strain Dr. Rasmussen tells us that the B.1.1.7 strain, better known as the “UK variant”, is worrisome. However, travel bans aren't an effective response to the new COVID-19 variant. The new strain was detected first in the UK, but that is likely because the UK is doing more genomic surveillance than most countries. They found it because they were looking, but it could have originated elsewhere. Dr. Rasmussen explains “travel bans are only really effective when you can guarantee that you would not be exporting the virus from one place to another”. And since we don't know for sure where the variant first-evolved, or where it has spread to, there is simply no way to design an effective travel ban. We also discuss:   How viruses mutate and evolve Why the new variant is believed to be more transmissible Potential behavior components that may have impacted the numbers That the known, non-pharmaceutical interventions work against every variant of SARS coronavirus (i.e., the virus hasn't mutated in a way that makes our masks, social-distancing, etc. less effective). We should double-down on those now.   Communicating Science to the Public We continue to examine communications lessons that can be learned from the COVID-19 pandemic. Dr Rasmussen tells us that scientists and media tend to make one of two mistakes:   They default to the worst case scenario and communicate in a very reactionary way They oversimplify things, trying to get the public to understand and comply with certain behaviors   Both approaches create gaps in understanding and acceptance of our message. To mitigate these issues, Dr. Rasmussen tells us to think about three key things whenever we're communicating science to the public:   Talk openly about what we don't know, and about the nuances, so that people become more comfortable with uncertainty End every message with actionable advice. Tell them what they can and should do right now to protect themselves. Repeat the message over and over. In a constantly evolving environment, we may be tempted to jump from topic to topic. Our messaging should always be grounded in the tried and true (e.g., the non-pharmaceutical interventions discussed earlier)   Vaccine Challenges We're dealing with a triple threat when it comes to the vaccine. First, we have our current distribution problems. There are vaccines available and they are being administered much more slowly than we'd like. Second, there are known supply challenges that could worsen if/when we alleviate the distribution delays. Third, we're dealing with vaccine “hesitancy” and the recent discussions around changing dosing regimens, despite the fact that we have no data to support those changes, might cast further doubt for those on the fence. Dr. Rasmussen shares her thoughts on these high-level issues, and gets into the details of each:   What is causing our distribution problems, and what are the steps that can be taken right now? What do we know about the potential for widespread supply issues, and how are our current efforts to head them off distracting us from the distribution problem we have right now? What will it take to achieve herd immunity and slow, or stop community transmission? Why the vaccine is a medium-to-long-term solution, and the importance of redoubling our efforts on non-pharmaceutical interventions to slow community spread in the near-term How we can use the tried-and-true epidemiological path, in conjunction with vaccination to slow community transmission and get us on the right path in the foreseeable future   Dr. Angela Rasmussen Dr. Rasmussen is a virologist studying host responses to infection by combining classical virology with modern systems biology approaches. Her research objectives are to identify host response signatures predictive of infection severity or disease outcome and host pathways to target drug development or repurposing. She is particularly interested in viruses that are highly pathogenic, newly emergent or likely to emerge because of climate change, land development, or ecological disruption. Currently she is focused on SARS-CoV-2, as well as other emerging pathogens with the potential to profoundly impact global health, such as Ebola virus, MERS-CoV, influenza virus, and hemorrhagic fever viruses. She works closely with other faculty and affiliates within the GHSS on the Viral Emergence Research Initiative (the VERENA Consortium), where she leads the core virology team. Dr. Rasmussen has employed uses in vitro systems, animal models, and clinical specimens to study the relationship between host response and pathogenesis. She previously developed a  model of Ebola virus disease in a genetically diverse panel of mice, the Collaborative Cross (CC), leveraging the diversity of CC mouse disease phenotypes to study genetic and transcriptomic factors underlying disease severity in humans. She has applied this model to developing predictive signatures of disease outcome and infection and identify novel drug targets. She is currently evaluating CC mouse models towards investigation of sex-specific host responses to viral infection, as well as to investigate disease presentation in other viruses that pose a major threat to global public health, including SARS-CoV-2. Ultimately, these host response profiles can be used for translational or biodefense applications, such as diagnosing infection, predicting disease severity, informing vaccine design, and developing or repurposing host-targeted drugs to impair virus replication or reverse pathology.  Dr. Rasmussen has published numerous original research articles in the peer-reviewed literature and serves on the editorial board of Cell Reports and mSphere. In addition to her scientific work, she believes that engagement of the public is essential to successful public health initiatives and is an active and outspoken science communicator. She has written for Forbes, Foreign Affairs, Slate, the Guardian, and Leapsmag, and appeared many times in media outlets including the New York Times, the Washington Post, National Public Radio, ABC, NBC, CNN, CBC, and BBC. She is also an advocate for equitable and inclusive science, and serves on the NIH Advisory Committee to the Director's Working Group on Changing the Culture to End Sexual Harassment.   Email: ar1692@georgetown.edu Web: https://angelarasmussen.org/ Twitter: @angie_rasmussen   Links and Resources   For mRNA vaccines, we should stick to the schedule Travel bans aren't an effective response to the new COVID-19 variant Pizza-sized boxes and paying a premium: Israel's COVID-19 vaccine rollout Canada has secured more vaccine doses per capita than anyone else, but it's been slow to administer them Doug Ford says Ontario will run out of Pfizer COVID-19 vaccines by end of next week

Emerging research suggests that a sizeable portion of individuals hospitalized due to COVID-19 develop cognitive and psychological sequelae.  In our conversation with Dr. Chaya Fridman, a board-certified neuropsychologist at Cornell, we discuss the ways that SARS-CoV-2 (the virus that causes COVID-19) may lead to neurocognitive impairment, including both direct effects of the virus and secondary factors (e.g., respiratory distress and treatments used in the Intensive Care Unit).  We review how the virus gains access to the central nervous system and the potential underlying mechanisms by which it causes an increased risk of stroke and other neurological issues.  We also examine the long-term effects of prior coronaviruses (SARS-CoV and MERS-CoV) to attempt to forecast the long-term effects of COVID-19, with a focus on how neuropsychological practice (both inpatient and outpatient) might be affected. Show notes are available at www.NavNeuro.com/63 _________________ If you’d like to support the show, here are a few easy ways: 1) Get APA-approved CE credit for listening to episodes: www.NavNeuro.com/INS  2) Tell your friends and colleagues about it 3) Subscribe (free) and leave an Apple Podcasts rating/review: www.NavNeuro.com/itunes 4) Contribute to the discussion in the comments section of the website (click the episode link listed above) or on Twitter (@NavNeuro)   Thanks for listening, and join us next time as we continue to navigate the brain and behavior! [Note: This podcast and all linked content is intended for general educational purposes only and does not constitute the practice of psychology or any other professional healthcare advice and services. No professional relationship is formed between hosts and listeners. All content is to be used at listeners’ own risk. Users should always seek appropriate medical and psychological care from their licensed healthcare provider.]

MERS-coV

En plena segunda ola, con nuestro país sumido en un nuevo estado de alarma y al borde de unas navidades más inciertas que nunca, Milenio Live reúne a cuatro de los médicos e investigadores que, desde hace casi un año, han venido informando al detalle sobre la pandemia que ha cambiado el mundo tal y como lo conocíamos. Iker Jiménez contará con el Dr. Tomás Camacho, jefe de servicio de análisis clínicos en los laboratorios Vithas Lab, y con el Dr. Javier Cantón, virólogo especialista en MERS-CoV. Además, a este análisis se unirá el Dr. Miguel Ángel Pertierra, especialista en otorrinolaringología, y el Dr. José Miguel Gaona, psiquiatra forense licenciado en medicina y cirugía. Junto a ellos, en el último Milenio Live del año, trataremos de entender qué puede pasar en las próximas semanas y lo que podemos esperar tras las fiestas. Escucha el episodio completo en la app de iVoox, o descubre todo el catálogo de iVoox Originals

Un equipo internacional de 200 científicos coordinado por el PhD Nevan Krogan, de la Universidad de California San Francisco, identificó las vulnerabilidades comunes de los últimos tres coronavirus mortales, incluyendo el de la actual pandemia, el SARS CoV 2. Conocer el punto débil y los mecanismos de interacción de estos temibles virus puede ayudar a combatirlos mejor y también estar preparados para futuras pandemias con otros coronavirus. RFI pudo conversar con uno de los “corresponding authors” principales. Hasta no hace mucho, los coronavirus en humanos provocaban resfriados o gripes no muy graves, pero desde hace veinte años han aparecido tres coronavirus letales, entre ellos el Sars CoV 2, de la actual pandemia. Pero, ¿si se pudiera conocer el punto débil o el talón de Aquiles de estos tres últimos coronavirus? Es lo que ha buscado un equipo internacional de 14 instituciones de renombre, incluido el Instituto Pasteur de Francia y que abarca a 200 científicos de distintas especialidades. El coordinador general fue Nevan Krogan, PhD, director del Instituto de Biociencias Cuantitativas (QBI) de la Universidad de California San Francisco (UCSF) y los resultados fueron publicados en la revista Science. El estudio incluyó el análisis de 740 mil registros médicos de pacientes infectados con el nuevo coronavirus. También se estudió qué drogas inhiben los mecanismos de estos tres coronavirus y se hizo un mapa de las interacciones que existen entre las proteínas de los virus y las proteínas de las células huésped humanas. Conocer las similitudes de estos tres coronavirus, el Sars Cov 1 del 2002, el Mers CoV del 2012 y el actual, el Sars Cov 2, ayuda a concebir futuros tratamientos para combatir la actual pandemia e incluso otras que puedan aparecer en el futuro. Aprovechando un mapa de proteínas o “interactoma” del Sars CoV2 (llevado a cabo en abril del 2020 y publicado en la revista Nature y Cell ) que registra cómo las proteínas de este virus interactúan con las proteínas de la célula huésped humana, los investigadores lograron esta vez construir los mapas de los tres coronavirus letales, destacando los mecanismos comunes que tienen. RFI conversó con el investigador en virología Adolfo García Sastre, profesor del departamento de microbiología de la prestigiosa Escuela de Medicina de Monte Sinaí en Nueva York, en pleno corazón de Manhattan. García Sastre es uno de los autores correspondientes, corresponding author, de esta vasta investigación. Las investigaciones en laboratorio llevadas a cabo por el equipo de Adolfo García Sastre se centran en los inhibidores, experimentando con diferentes drogas ya existentes, entre ellas, el remdesivir. Así también RFI  entrevistó al bioquímico Iñigo Barrio Hernández, él trabaja con el equipo de Pedro Beltrao, del Instituto Europeo de Bioinformática  en Hinxton, cerca de Cambridge, en el Reino Unido, una filial del EMBL, Laboratorio Europeo de Biología Molecular. Escuche aquí el programa en su versión larga con los dos especialistas: Esta investigación, es sobre todo la suma de muchos esfuerzos en el mundo científico y son varios aspectos que se tratan. Entrevistados: El virólogo Adolfo García Sastre del departamento de Microbiología, de la Icahn School of Medicine at Mount Sinai, Nueva York e Iñigo Barrio Hernández del Instituto Europeo de bioinformática del EMBL, European Molecular Biology Laboratory (EMBL-EBI), Hinxton, Reino Unido.            

As the cell employs its machinery to shut down the virus that's inside it, the virus makes proteins to shut down the cell's efforts. The scene is set, but how will this arms race end? The answer depends on many, many factors.   Listeners can tune in to explore the following: How to study the way in which obesity, diabetes, and host immunosuppressive states alter the trajectory of viral disease like that caused by SARS-CoV-2 Whether it's possible to create drugs that can combat viruses that don't yet exist How SARS-CoV-2 enters cells, with a play-by-play look at what exactly is does prior, during, and after entry What evidence suggests that SARS-CoV-2 had been replicating in humans for a while—potentially months—before anyone knew about it Since 2004, Matthew Frieman, PhD has been researching coronaviruses. In 2009, he established his own research lab at the University of Maryland School of Medicine, where he is an associate professor in the area of microbiology and immunology. First it was SARS-CoV, then MERS-CoV, and now SARS-CoV-2, the virus causing COVID-19. With each new coronavirus, he learns a little bit more about the tricks they use to enter and infect cells. He also learns more and more about therapeutics which could potentially combat the current virus and viruses to come. A focal point of the research in Frieman's lab is on the role of comorbidity in disease progression, and how an understanding of this in lab mice might be reflected in humans. For instance, why do those with underlying conditions appear significantly more vulnerable to SARS-CoV-2, and more likely to suffer severe symptoms? His research is also focused on developing a broadly antiviral drug not only for SARS-CoV-2, but for viruses that emerge in the future. The conversation covers the similarities and differences between SARS-CoV-1 and SARS-CoV-2, two primary entry methods of SARS-CoV-2, the role of the ACE2 receptor and TMPRSS2 protease, why more virions per cell means fewer ACE2 receptors, which means decreased capacity for lung tissue repair, how cells detect the presence of a virus and respond accordingly,  characteristics of viral spread, structure, and function, virus-host interactions, research aimed at combining antibodies to create a dual antiviral effect against SARS-CoV-2, and so much more. Visit https://www.medschool.umaryland.edu/profiles/Frieman-Matthew/ and follow Frieman on Twitter @MattFrieman.  Available on Apple Podcasts: apple.co/2Os0myK

Lisa joins TWiV to discuss her research on the pathogenesis of SARS-CoV, MERS-CoV, and SARS-CoV-2, including work on vaccines and an antiviral, then we review the SARS-CoV-2 spike protein as a potential analgesic, and listener questions. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker Guest: Lisa Gralinski Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode SARS-like bat CoV with potential for human emergence (Nat Med) SARS-CoV susceptibility loci in CC mice (PLoS Genetics) Combination attenuation for SARS-CoV vaccine (J Virol) Orally administered SARS-CoV-2 antiviral (Res Sq) Spike protein induces analgesia (Pain) Letters read on TWiV 674 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne – The Lonely Pipette Podcast: Mentoring with Harmit Malik Kathy –  Dr. Boyd the Chemist one and two  GREAT short videos one and two,  How to read an old school thermometer, New Marvel storyline  Wear a Mask parody of Be My Guest Rich – Clear+Vivid with Alan Alda Vincent – Immune 36: Aberrant immunity in COVID-19 Listener Pick Ryan – Dr. Fauci on politicization of pandemic Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv  

Lisa joins TWiV to discuss her research on the pathogenesis of SARS-CoV, MERS-CoV, and SARS-CoV-2, including work on vaccines and an antiviral, then we review the SARS-CoV-2 spike protein as a potential analgesic, and listener questions. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker Guest: Lisa Gralinski Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode SARS-like bat CoV with potential for human emergence (Nat Med) SARS-CoV susceptibility loci in CC mice (PLoS Genetics) Combination attenuation for SARS-CoV vaccine (J Virol) Orally administered SARS-CoV-2 antiviral (Res Sq) Spike protein induces analgesia (Pain) Letters read on TWiV 674 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne – The Lonely Pipette Podcast: Mentoring with Harmit Malik Kathy –  Dr. Boyd the Chemist one and two  GREAT short videos one and two,  How to read an old school thermometer, New Marvel storyline  Wear a Mask parody of Be My Guest Rich – Clear+Vivid with Alan Alda Vincent – Immune 36: Aberrant immunity in COVID-19 Listener Pick Ryan – Dr. Fauci on politicization of pandemic Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv  

En unas semanas especialmente inciertas, Mediaset España continúa apostando por la información sobre la pandemia que ha cambiado el mundo tal y como lo conocíamos. El próximo jueves, tras la segunda edición de Informativos Telecinco, Iker Jiménez y Carmen Porter se ponen de nuevo al frente de un nutrido grupo de virólogos, médicos e investigadores para analizar aquellas preguntas en relación a la COVID-19 que continúan sin respuesta. Tras abordar las principales dudas que implican a los niños, la importancia de los aerosoles en la transmisión del virus o cuestionar los errores que nuestro país ha cometido durante la segunda ola de la pandemia, el próximo jueves Informe Covid volverá a llevar al prime time de Telecinco a muchos de los especialistas que, desde hace seis meses, han informado sin descanso sobre el SARS-CoV-2, contando todo lo que casi nadie cuenta. En su cuarta entrega el programa analizará las luces y sombras de la posible vacuna contra el virus. La gran esperanza, que algunos analistas creen inminente mientras otros la sitúan prácticamente en 2022, lleva semanas envuelta en la polémica. La incertidumbre planea sobre los intentos rusos o chinos, envueltos en más dudas que certezas, pero también se extiende por los efectos secundarios y trastornos que han provocado otros ensayos, aparentemente prometedores. ¿Cuándo asistiremos a una vacunación masiva? ¿Qué grado de efectividad podrían tener esos esperados remedios? ¿Producirán anticuerpos e inmunidad de forma segura? Iker Jiménez contará con la presencia en plató del Dr. Javier Cantón, virólogo especialista en coronavirus MERS-CoV que ha sido inoculado con una de las vacunas actualmente en desarrollo. Le acompañarán el Dr. Amós García Rojas, jefe de sección de Epidemiología y Prevención de la Dirección General de Salud Pública del Gobierno de Canarias, el Dr. César Carballo, adjunto de urgencias en el Hospital Universitario Ramón y Cajal (Madrid), y el psiquiatra José Miguel Gaona, para intentar aportar luz a todas las dudas gracias a su experiencia profesional. Además, el programa hablará con el Dr. Luke O’Neill, profesor de bioquímica e inmunólogo del Trinity College de Dublín, y con el Dr. Carlos Estévez-Fraga, neurólogo que, desde Londres, trabaja actualmente como investigador adjunto de la vacuna de Oxford y AstraZeneca. Informe Covid también contará, como cada jueves, con el investigador Pablo Fuente, una de las figuras esenciales en la divulgación de todo lo relacionado con este virus y que a principios de febrero se adelantó con precisión milimétrica al escenario al que España tuvo que enfrentarse semanas después. Pablo y Carmen Porter serán los encargados una semana más de diseccionar todos los datos y estadísticas para que podamos entender de forma sencilla y didáctica el complejo rompecabezas de esta pandemia. Según datos de Kantar, la tercera emisión de Informe Covid, el pasado jueves, se saldó con un 14 % de share y 2.143.000 espectadores, situándose como líder en su franja horaria. Iker Jiménez ha sido uno de los comunicadores más seguidos tanto en las reposiciones de Cuarto Milenio como en su canal de YouTube con la Estirpe de los Libres, un formato que acumula más 15 millones de visualizaciones desde su estreno en abril y que le ha convertido en una de las figuras de referencia durante la pandemia. Escucha el episodio completo en la app de iVoox, o descubre todo el catálogo de iVoox Originals

Sars-CoV, MERS-CoV, CCoV formam tipo uma sopa de letrinhas, e vão ajudar você a entender um pouco melhor sobre os coronavírus nos seres humanos e em nossos animais de estimação ---------------------------------------------- Nesta nova temporada de episódios do Podcast Movimento Pet, vamos falar sobre a relação do novo coronavírus e da pandemia de COVID-19 com os nossos animais de estimação. Acompanhe os nossos episódios para entender tudo o que você precisa saber para ajudar o seu bichinho! ---------------------------------------------- Este podcast é um patrocínio de Fórmula Animal Farmácia de Manipulação Veterinária. Para orçamentos, entre em contato no telefone (31) 2528 0988 ou whatsapp (31) 99545 ​​5407  ----------------------------------------------Edição do programa pela Orange DCM.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.15.298604v1?rss=1 Authors: Trinity, L., Lansing, L., Jabbari, H., Stege, U. Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to the COVID-19 pandemic; a pandemic of a scale that has not been seen in the modern era. Despite over 29 million reported cases and over 900,000 deaths worldwide as of September 2020, herd immunity and widespread vaccination efforts by many experts are expected to be insufficient in addressing this crisis for the foreseeable future. Thus, there is an urgent need for treatments that can lessen the effects of SARS-CoV-2 in patients who become seriously affected. Many viruses including HIV, the common cold, SARS-CoV and SARS-CoV-2 use a unique mechanism known as -1 programmed ribosomal frameshifting (-1 PRF) to successfully replicate and infect cells in the human host. SARS-CoV (the coronavirus responsible for SARS) and SARS-CoV-2 possess a unique RNA structure, a three-stemmed pseudoknot, that stimulates -1 PRF. Recent experiments identified that small molecules can be introduced as antiviral agents to bind with the pseudoknot and disrupt its stimulation of -1 PRF. If successfully developed, small molecule therapy that targets -1 PRF in SARS-CoV-2 is an excellent strategy to improve patients' prognoses. Crucial to developing these successful therapies is modeling the structure of the SARS-CoV-2 -1 PRF pseudoknot. Following a structural alignment approach, we identify similarities in the -1 PRF pseudoknots of the novel coronavirus SARS-CoV-2, the original SARS-CoV, as well as a third coronavirus: MERS-CoV, the coronavirus responsible for Middle East Respiratory Syndrome (MERS). In addition, we provide a better understanding of the SARS-CoV-2 -1 PRF pseudoknot by comprehensively investigating the structural landscape using a hierarchical folding approach. Since understanding the impact of mutations is vital to long-term success of treatments that are based on predicted RNA functional structures, we provide insight on SARS-CoV-2 -1 PRF pseudoknot sequence mutations and their effect on the resulting structure and its function. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.11.293258v1?rss=1 Authors: Rynkiewicz, P. X., Babbitt, G. A., Cui, F. X., Hudson, A. O., Lynch, M. L. Abstract: Comparative functional analysis of the binding interactions between various betacoronavirus strains and their potential human target proteins, such as ACE1, ACE2 and CD26, is critical to our future understanding and combating of COVID-19. Here, employing large replicate sets of GPU accelerated molecular dynamics simulations, we statistically compare atom fluctuations of the known human target proteins in both the presence and absence of different strains of the viral receptor binding domain (RBD) of the S spike glycoprotein. We identify a common interaction site between the N-terminal helices of ACE2 and the viral RBD in all strains (hCoV-OC43, hCoV-HKU1, MERS-CoV, SARS-CoV1, and SARS-CoV-2) and a second more dynamically complex RBD interaction site involving the ACE2 amino acid sites K353, Q325, and a novel motif, AAQPFLL (386-392) in the more recent cross-species spillovers (i.e. absent in hCoV-OC43). We use computational mutagenesis to further confirm the functional relevance of these sites. We propose a "one touch/two touch" model of viral evolution potentially involved in functionally facilitating binding interactions in zoonotic spillovers. We also observe these two touch sites governing RBD binding activity in simulations on hybrid models of the suspected viral progenitor, batCoV-HKU4, interacting with both the human SARS target, ACE2, and the human MERS target, CD26. Lastly, we confirm that the presence of a common hypertension drug (lisinopril) within the target site of SARS-CoV-2 bound models of ACE1 and ACE2 acts to enhance the RBD interactions at the same key sites in our proposed model. In the near future, we recommend that our comparative computational analysis identifying these key viral RBD-ACE2 binding interactions be supplemented with comparative studies of site-directed mutagenesis in order to screen for current and future coronavirus strains at high risk of zoonotic transmission to humans. Copy rights belong to original authors. Visit the link for more info

On today's episode we discuss: —Epidemiology: Experienced scientists from the Center for Tobacco Control Research and Education at the University of California San Francisco conducted a meta-analysis of 19 peer-reviewed papers involving 11,590 COVID-19 patients. They found a positive association between smoking and severe progression of COVD-19. Authors suggest that while this data clearly shows smoking puts COVID-19 patients at increased risk for disease progression, the actual risk may be even higher due to limitations in the reviewed papers. —Transmission & Prevention: Infection control experts from West China Hospital of Sichuan University in Chengdu discuss prevention measures implemented to protect healthcare workers (HCW) across China, including mask-wearing for workers, securing and providing personal protective equipment, using fluid resistant protective clothing and respirators, allocating specific hospitals for COVID-19 patients, and enacting strict community lockdown procedures. —Adjusting Practice During COVID-19: Spanish dermatologists discuss a scabies outbreak in their region during the nationwide lockdown in March-May, 2020, with a three-fold increase in reported cases at a single hospital compared to the same period in the previous five years. Authors suggest that time spent in confinement increased fomite transmission and that individuals were less likely to seek treatment until the scabies lesions became more serious leading to more cases in family clusters, longer infection time due to reinfection, and the need for more aggressive treatment regimens to treat resistant infections. —R&D: Diagnosis & Treatments: Lab scientists from the Tamil Nadu Veterinary and Animal Sciences University in Chennai, India reviewed the limited existing literature related to antibody-dependent enhancement (ADE) and its potential impact on the effectiveness of immunotherapy and vaccine development for SARS-CoV-2. Citing evidence from research on MERS-CoV and SARS-CoV, authors suggest ADE, which occurs when non-neutralizing or poorly neutralizing antibodies increase viral entry into cells, may intensify coronavirus infection. However, they propose targeting receptor binding motifs as a possible mitigation strategy. —Mental Health & Resilience Needs: A representative panel survey of adults (n=5,470) conducted across the United States by Australian and American researchers found the mental health impact of COVID-19 disproportionately affected young adults, certain racial/ethnic minorities, essential workers, unpaid adult caregivers, and individuals with pre-existing psychiatric conditions. Authors recommend COVID-19-specific mental health interventions and prevention efforts be implemented to improve care for the at-risk populations identified by this study. —Silver Linings: Utilizing data from the Epidemiological Surveillance Network from Madrid Autonomous Community, epidemiologists from Madrid, Spain compared the number of cases of reportable communicable diseases in the first quarter of 2020 compared to 2019. --- Support this podcast: https://anchor.fm/covid19lst/support

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.17.254839v1?rss=1 Authors: Reese, J. T., Unni, D. R., Callahan, T. J., Cappelletti, L., Ravanmehr, V., Carbon, S., Fontana, T., Blau, H., Matentzoglu, N., Harris, N. L., Munoz-Torres, M. C., Robinson, P. N., Joachimiak, M. P., Mungall, C. J. Abstract: Integrated, up-to-date data about SARS-CoV-2 and coronavirus disease 2019 (COVID-19) is crucial for the ongoing response to the COVID-19 pandemic by the biomedical research community. While rich biological knowledge exists for SARS-CoV-2 and related viruses (SARS-CoV, MERS-CoV), integrating this knowledge is difficult and time consuming, since much of it is in siloed databases or in textual format. Furthermore, the data required by the research community varies drastically for different tasks - the optimal data for a machine learning task, for example, is much different from the data used to populate a browsable user interface for clinicians. To address these challenges, we created KG-COVID-19, a flexible framework that ingests and integrates biomedical data to produce knowledge graphs (KGs) for COVID-19 response. This KG framework can also be applied to other problems in which siloed biomedical data must be quickly integrated for different research applications, including future pandemics. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.13.248575v1?rss=1 Authors: Park, J. J., Chen, S. Abstract: The COVID-19 pandemic caused by SARS-CoV-2 has become a major threat across the globe. Here, we developed machine learning approaches to identify key pathogenic regions in coronavirus genomes. We trained and evaluated 7,562,625 models on 3,665 genomes including SARS-CoV-2, MERS-CoV, SARS-CoV and other coronaviruses of human and animal origins to return quantitative and biologically interpretable signatures at nucleotide and amino acid resolutions. We identified hotspots across the SARS-CoV-2 genome including previously unappreciated features in spike, RdRp and other proteins. Finally, we integrated pathogenicity genomic profiles with B cell and T cell epitope predictions for enrichment of sequence targets to help guide vaccine development. These results provide a systematic map of predicted pathogenicity in SARS-CoV-2 that incorporates sequence, structural and immunological features, providing an unbiased collection of genetic elements for functional studies. This metavirome-based framework can also be applied for rapid characterization of new coronavirus strains or emerging pathogenic viruses. Copy rights belong to original authors. Visit the link for more info

Studies cited: Comparison Of the Covid 2019 ( SARS2) pathogenesis with SARS Cov 1and MERS Cov infections Future Virology: 2020May. https://doi.org/102217/fvl-2020-0050   Zinc Deficiency     Laya Caulfield and Robert Black https://www.who.int/publications    Zinc ions and the fight against SARS https://www.bmj.com/rapid-response/2011/10/29/zinc-ions-and-fight-against-sars British Medical Journal 2003;326 dpi BMJ 2003;326:409   British Medical Journal - immunutrition for fighting Covid 19 https://nutrition.bmj.com/content/early/2020/05/04/bmjnph-2020-000071   In this program California's former Commissioner On Aging, Brian Johnston explores the current cultural ‘climate’ surrounding the COVID-19 debate. Brian has spent years in researching and advocating the most effective ways to protect the medically vulnerable and cherish their lives. Today, he discusses the now intentional fear mongering and dismissal of startlingly obvious science by those who prefer a ‘police state’ approach to illness.  Common sense and medical ethics would direct caregivers to provide treatment and boost the immune system of all vulnerable and immunodeficient individuals. But instead, large swaths of government and an accommodating media have adopted the ‘objectified approach’ to individuals, the same policy as the Chinese Communist government. Earlier programs of Life Matters have deeply explored the actual documents and scientific evidence of how hydroxychloroquine works in its treatment against various viruses, including the SARS 2 virus, commonly referred to as COVID-19. Brian, in discussing literature and film surrounding dystopian cultures and science fiction, draws a contrastive analysis with today's 'real life' approach that is now subjecting large populations to greater hardships and government oppression.  Two specific works, M. Night Shyamalan’s Signs, and the various iterations of H.G. Wells', War of the Worlds, provide dramatic insight into the current ‘terror of the unknown,' which government entities are both fomenting and using for other expansions of government authority. The World Health Organization and its Bureau of Taxonomy (the naming of illnesses and viruses) have named the virus which causes the COVID-19 illness as officially, "Severe Acute Respiratory Syndrome 2 - Covid (SARS 2)”.  It is nearly identical to the first severe acute respiratory syndrome, SARS 1. (Virology, May 2020)  But if it was routinely referred to as SARS 2, the average person would logically consider the fact that we have faced a SARS epidemic before (2003-2004) and what we are doing now was NOT how we addressed it.  Brian again takes a deep dive into the documented, international virology reports on the nature of zinc and zinc transport in attacking viruses. The efficacy of zinc has been long demonstrated, and the use of hydroxychloroquine is actually very effective because its sole purpose in addressing viruses is to help zinc transport through cellular walls. (Caulfield) Viruses attack us on the cellular level, mimicking proteins. The presence of zinc prohibits viral reproduction. It is the intentional suppression of these documented facts that has led to thousands of deaths, particularly in nursing homes and in immunodeficient populations.   Brian points out our current cultural environment ignores the value of these individual lives. Their value and protection as individuals has been taken from them.  It is intentionally causing widespread ‘surrender' to fear and ignorance.  This is not science fiction. It is happening to us - now. This inchoate fear being spread by a controlling media culture can only be ended when freedom of speech and objective facts are allowed to be examined. 'Cancel culture' and political hatred of the current administration is apparently a root cause of this cultural phenomenon. Literally dozens of studies have demonstrated the efficacy of zinc and hydroxychloroquine. The current suppression of these studies is an assault on the doctor-patient relationship, the freedom of speech of conscientious doctors, and an oppressive attempt by governments to continue a fearful response to this illness.  The politicization of this illness is unconscionable and those who are doing so should be held directly responsible.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.13.250076v1?rss=1 Authors: Zhang, D., Lu, J. Abstract: The COVID-19 pandemic has exposed global inadequacies in therapeutic options against both the COVID-19-causing SARS-CoV-2 virus and other newly emerged respiratory viruses. In this study, we present the VirusSi computational pipeline, which facilitates the rational design of siRNAs to target existing and future respiratory viruses. Mode A of VirusSi designs siRNAs against an existing virus, incorporating considerations on siRNA properties, off-target effects, viral RNA structure and viral mutations. It designs multiple siRNAs out of which the top candidate targets >99% of SARS-CoV-2 strains, and the combination of the top four siRNAs is predicted to target all SARS-CoV-2 strains. Additionally, we develop Greedy Algorithm with Redundancy (GAR) and Similarity-weighted Greedy Algorithm with Redundancy (SGAR) to support the Mode B of VirusSi, which pre-designs siRNAs against future emerging viruses based on existing viral sequences. Time-simulations using known coronavirus genomes as early as 10 years prior to the COVID-19 outbreak show that at least three SARS-CoV-2-targeting siRNAs are among the top 30 pre-designed siRNAs. Before-the-outbreak pre-design is also possible against the MERS-CoV virus and the 2009-H1N1 swine flu virus. Our data support the feasibility of pre-designing anti-viral siRNA therapeutics prior to viral outbreaks. We propose the development of a collection of pre-designed, safety-tested, and off-the-shelf siRNAs that could accelerate responses toward future viral diseases. Copy rights belong to original authors. Visit the link for more info

This week, we speak to vaccine development expert Professor Nikolai Petrovsky from South Australia. He is the Director of Endocrinology at Flinders Medical Centre, a Professor in the School of Medicine at Flinders University and the founder of Vaxine Pty Ltd, an Adelaide-based biotechnology company specialising in pandemic vaccine design. Professor Petrovsky joins the MTPConnect podcast to update us on his promising vaccine candidate - COVAX-19, with a recombinant spike protein approach, that has recently successfully completed Phase 1 trials at Royal Adelaide Hospital. It's a thought provoking discussion covering vaccine development, funding, access issues and manufacturing capabilities, future pandemic preparedness and what we can learn from past outbreaks to protect us against other threats like MERS-CoV. He also reveals how the vaccine mapping project funded by MTPConnect as a part of the Industry Growth Centre Project Fund Program helped accelerate their current COVAX-19 research program. Listen for a fascinating chat.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.11.232520v1?rss=1 Authors: Fu, Y., Pistolozzi, M., Yang, X., Lin, Z. Abstract: In this work, we present a unified and robust classification scheme for coronaviruses based on concatenated protein clusters. This subsequently allowed us to infer the apparent 'horizontal gene transfer' events via reconciliation with the corresponding gene trees, which we argue can serve as a marker for cross-host transmissions. The cases of SARS-CoV, MERS-CoV, and SARS-CoV-2 are discussed. Our study provides a possible technical route to understand how coronaviruses evolve and are transmitted to humans. Copy rights belong to original authors. Visit the link for more info

Citations: Comparison Of the Covid 2019 ( SARS2) pathogenesis with SARS Cov 1and MERS Cov infections Future Virology: 2020May. https://doi.org/102217/fvl-2020-0050 Zinc Deficiency     Laya Caulfield and Robert Black https://www.who.int/publications  Zinc ions and the fight against SARS British Medical Journal 2003;326 dpi BMJ 2003;326:409 In one of the most stunning and invasive actions against medical ethics, the major media and many state government organizations have acted to suppress documented medical evidence that there are treatments available for the COVID-19 illness. (America’s Frontline Doctors, July 2020)  In this program, Mr. Brian Johnston, who has spent years in researching and advocating the most effective ways to protect the medically vulnerable, discusses the actual documents and scientific evidence of how hydroxychloroquine works in its treatment against various viruses including the SARS 2 virus, commonly referred to as COVID-19. The World Health Organization and its Bureau of Taxonomy (the naming of illnesses and viruses) have named the virus which causes the COVID-19 illness officially as Severe Acute Respiratory Syndrome 2 - Covid (SARS 2) it is nearly identical to the first Severe Acute Respiratory Syndrome, SARS 1. (Virology May 2020)  But if it was routinely referred to as SARS 2, the average person would logically consider the fact that we have faced a SARS epidemic before (2003-2004) and what we are doing now was NOT how we addressed it.  Brian takes a deep dive into the documented international virology reports on the nature of zinc and zinc transport in attacking viruses. The efficacy of zinc has been long demonstrated, and the use of hydroxychloroquine is actually very effective because its sole purpose in addressing viruses is to help zinc transport through cellular walls. (Caulfield) Viruses attack us on the cellular level, mimicking proteins. The presence of zinc prohibits viral reproduction. Literally dozens of studies have demonstrated the efficacy of zinc and hydroxychloroquine. The current suppression of these studies is an assault on the doctor-patient relationship, the freedom of speech of conscientious doctors, and an oppressive attempt by governments to continue a fearful response to this illness.  The politicization of this illness is unconscionable and those who are doing so should be held directly responsible.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.02.233510v1?rss=1 Authors: Hu, X., Hao, W., Qin, B., Tian, Z., Li, Z., Hou, P., Zhao, R., Cui, S., Diao, J. Abstract: The current COVID-19 pandemic urges in-depth investigation into proteins encoded with coronavirus (CoV), especially conserved CoV replicases. The nsp13 of highly pathogenic MERS-CoV, SARS-CoV-2, and SARS-CoV exhibit the most conserved CoV replicases. Using single-molecule FRET, we observed that MERS-CoV nsp13 unwound DNA in discrete steps of approximately 9 bp when ATP was used. If another NTP was used, then the steps were only 4 to 5 bp. In dwell time analysis, we detected 3 or 4 hidden steps in each unwinding process, which indicated the hydrolysis of 3 or 4 dTTP. Based on crystallographic and biochemical studies of CoV nsp13 helicases, we modeled an unwinding mechanism similar to the spring-loaded mechanism of HCV NS3 helicase, although our model proposes that flexible 1B and stalk domains, by allowing a lag greater than 4 bp during unwinding, cause the accumulated tension on the nsp13-DNA complex. The hinge region between two RecA-like domains in SARS-CoV-2 nsp13 is intrinsically more flexible than in MERS-CoV nsp13 due to the difference of a single amino acid, which causes the former to induce significantly greater NTP hydrolysis. Our findings thus establish a blueprint for determining the unwinding mechanism of a unique helicase family. Copy rights belong to original authors. Visit the link for more info

On today's episode we discuss: — Climate: The Immunization Action Coalition and the Vanderbilt School of Medicine discuss the progress of developing a COVID-19 vaccine, detailing the 11 vaccines in phase 1/2 clinical trials and the inclusion of multiple countries in the development of a Target Product Profile, a tool for quantifying critical vaccine characteristics. The authors emphasize the need for well-established infrastructure and logistical planning in order to distribute a potential COVID-19 vaccine safely and effectively to the world in a timely manner. — Epidemiology: Researchers in the United States and United Kingdom used Twitter data to predict human mobility in and out of China and estimate global spread of COVID-19 and found a high correlation between country-level Twitter user visits and reported COVID-19 cases. These findings highlight the utility of geolocated platforms for public health authorities to develop response protocols and assess impending risks of COVID-19. — Transmission and Prevention: Based on literature of prostaglandins in SARS-CoV-1 and MERS-CoV, a group from the University of Edinburgh cite the potential roles of multiple prostaglandins (including PGD2, PGE2, PGI2) in the pathogenesis of COVID-19 and consider the possible benefits of NSAID usage in COVID-19 patients. — Management: A study found that among 59 patients with symptoms consistent with COVID-19, fibrinogen levels were markedly higher in patients who ultimately tested positive on RT-PCR compared to those who tested negative. Additionally, the neutrophil-to-lymphocyte ratio was increased in critically ill COVID-19 patients. These results suggest that fibrinogen may have value as a diagnostic marker in patients with suspected COVID-19 and that neutrophil to lymphocyte ratio may be useful as a prognostic marker indicative of COVID-19 disease severity. — Adjusting Practice: A cross sectional study of 26 heart failure patients found a 16.2% decrease in daily step count on wearable accelerometers during the first 3 weeks of quarantine compared to regular activity suggesting that widespread COVID-19 quarantine mandates were detrimental to physical activity habits in these patients. These findings highlight the importance of physical activity during the pandemic in reducing deterioration in cardiovascular health. — R&D Diagnosis and Treatment: Investigators in China measured SARS-CoV-2-specific antibodies among moderate and severe COVID-19 patients as well as non-COVID-19 patients and found that IgA and IgG were higher among severe patients compared to moderate patients whereas no difference was observed between the groups in IgM. Based on their findings, the authors suggest that IgA-IgG serological diagnosis of COVID-19 may be more effective than the traditional detection of IgM-IgG combined antibodies. --- Support this podcast: https://anchor.fm/covid19lst/support

In one of the most stunning and invasive actions against medical ethics, the major media and many state government organizations have acted to suppress documented medical evidence that there are treatments available for the COVID-19 illness. (America’s Frontline Doctors, July 2020)  In this program, Mr. Brian Johnston, who has spent years in researching and advocating the most effective ways to protect the medically vulnerable, discusses the actual documents and scientific evidence of how Hydroxychloroquine works in its treatment against various viruses including the SARS 2 virus, commonly referred to as COVID-19.   The world health organization and its Bureau of Taxonomy (the naming of illnesses and viruses) have named the virus which causes the COVID-19 illness as officially Severe Acute Respiratory Syndrome 2 - Covid (SARS 2) it is nearly identical to the first Severe Acute Respiratory Syndrome, SARS 1. (Virology May 2020)  But if it was routinely referred to as SARS 2, the average person would logically consider the fact that we have faced a SARS epidemic before (2003-2004) and what we are doing now was NOT how we addressed it.  Brian takes a deep dive into the documented international virology reports on the nature of zinc and zinc transport in attacking viruses. The efficacy of zinc has been long demonstrated, and the use of hydroxychloroquine is actually very effective because its sole purpose in addressing viruses is to help zinc transport through cellular walls. (Caulfield) Viruses attack us on the cellular level, mimicking proteins. The presence of zinc prohibits viral reproduction. Literally dozens of studies have demonstrated the efficacy of zinc and hydroxychloroquine. The current suppression of these studies is an assault on the doctor- patient relationship, the freedom of speech of conscientious doctors, and an oppressive attempt by governments to continue a fearful response to this illness.  The politicization of this illness is unconscionable and those who are doing so should be held directly responsible.   Citations  1. Comparison Of the Covid 2019 ( SARS2) pathogenesis with SARS Cov 1and MERS Cov infections Future Virology: 2020May. https://doi.org/102217/fvl-2020-0050 2. Zinc Deficiency     Laya Caulfield and Robert Black https://www.who.int/publications  3. Zinc ions and the fight against SARS British Medical Journal 2003;326 dpi BMJ 2003;326:409

“Super-spreaders” em inglês, ou supercontaminadores em tradução livre, são indíviduos que transmitem uma doença para um número bem maior de pessoas em comparação à média da chamada taxa de reprodutibilidade, o R0, termo popularizado pela epidemia da Covid-19. No caso da epidemia do coronavírus, manter o R0 abaixo de um é fundamental para evitar que o vírus se propague de maneira desenfreada, provocando o colapso do sistema de saúde, situação observada em diversos países europeus na primeira onda. Na prática, isso significa que um doente, sintomático ou não, contamina menos do que uma pessoa – na França, o R0 já está em 1,20 e as autoridades seguem alertas para evitar um novo pico epidêmico. Com o fim do confinamento e o relaxamento das medidas de proteção, como uso de máscaras e o distanciamento social, o risco de aparecimento dos “super-spreaders” aumenta e pode desencadear uma rápida propagação do vírus. Foi o caso do primeiro pico epidêmico na França, onde um encontro reuniu, em fevereiro, milhares de pessoas de uma igreja evangélica em Mulhouse, no leste do país, uma das regiões mais atingidas pela epidemia. Considerada como um dos primeiros focos de propagação do SARS-Cov-2 na França, a reunião resultou na morte de 72 pessoas e contribuiu para a difusão do vírus em todo o território nacional. O número de casos foi atribuído pelos especialistas à presença de um supercontaminador em uma situação propícia à infecção – pessoas próximas, em um local fechado, cantando e se tocando. “O fenômeno de supercontaminação é uma medida dessa heterogeneidade, dessa variação no número de casos que uma pessoa infecta”, disse o epidemiologista Julien Riou, da Universidade de Berna, na Suíça, em entrevista à RFI Brasil. Ele explica que se o R0 estiver a 2, por exemplo, um doente vai, em média, passar o vírus para outros dois indivíduos. Já um supercontaminador pode transmitir para trinta ou mais. “Esse novo coronavírus tende a criar mais variabilidade. Há muitas pessoas que transmitem pouco e poucas que transmitem muito”, explica. Esse também era o caso o SARS 1-Cov-1, que surgiu em 2001 na China, e do MERS-Cov, ambos parentes do SARS-Cov-2, que surgiu na Arábia Saudita em 2013. Os fatores que levam alguém a espalhar mais a Covid-19 do que os outros não estão totalmente explicados, mas sabe-se que, em algumas pessoas, o vírus vai se multiplicar muito e estar presente em grande quantidade nos espirros e nas secreções. Fatores sociais O fator social também é decisivo: quando os contatos se multiplicam, associados a situações de risco, podem gerar fenômenos de supercontaminação. É o caso de locais que reúnem muita gente, como hospitais, encontros religiosos, empresas, casas de repouso ou reuniões públicas lotadas, mesmo a céu aberto. “Sabemos que o supercontaminador existe, mas não conseguimos ainda entender, em detalhes, quem ele é”, diz o epidemiologista. No caso da gripe os "super-spreaders" em geral são pessoas que têm doenças autoimunes ou várias patologias. Elas espalham o vírus por mais tempo, porque têm mais dificuldade em eliminá-lo. Mas, em relação à Covid-19, não há estudos suficientes que permitam tirar tais conclusões. A supercontaminação existe, é fato, e há casos documentados – um dos mais impressionantes é o de um operário em Gana, na África, que teria contaminado sozinho 533 funcionários de uma fábrica. Flutuações Todo mundo pode cruzar com uma bomba viral humana. Por isso, restringir os contatos sociais para preservar a si mesmo e sua família é essencial, lembra o especialista. A estratégia europeia, diz, permitiu controlar a epidemia e é preciso manter as orientações preconizadas pelas autoridades. “A Europa foi a área mais atingida depois da China. Tivemos situações dramáticas na Itália, na França, mas as pessoas perceberam a gravidade da situação e aceitaram o confinamento. Foi um sacrifício enorme confinar”, diz. As medidas foram tomadas um pouco tarde demais, mas funcionaram – o que não era certo. O resultado é que esse esforço coletivo deu certo, levando ao controle da epidemia, contrariamente ao Brasil e aos Estados Unidos. O epidemiologista suíço prefere falar em “flutuações” do que em uma segunda onda epidêmica. “Enquanto não houver uma vacina, haverá flutuação com aumento e queda do número de casos. A transmissão depende do número de contatos que temos com outras pessoas”, lembra.  A questão é matemática: quanto mais a população relaxar, maior será o número de casos. Para Julien Riou, como o confinamento funcionou, as pessoas agora estão preparadas para aceitar medidas rígidas para controlar a propagação do vírus. “É necessário encontrar um meio termo entre a economia, a atividade e o controle”, reitera.

So let's talk about this Coronavirus Pandemic. While many of us are anxiously anticipating the end of this disruption in our normal lives, it seems the "Rona" ain't done with us just yet. Amerikan Therapy sits down with two of the country's foremost experts in the space, who just happen to be highly melanated, in order to weigh in on what's the next step in this pandemic. Given the recent spikes in the virus spread coupled with many cities grappling with the need to close back down and/ or open back up schools in August, there is so much to discuss. This is a rich discussion on how black folks can keep themselves and their families safe and sane during these difficult times. Georges C. Benjamin, MD - Executive Director, American Public Health Association: Georges Benjamin is known as one of the nation’s most influential physician leaders because he speaks passionately and eloquently about the health issues having the most impact on our nation today. From his firsthand experience as a physician, he knows what happens when preventive care is not available and when the healthy choice is not the easy choice. As executive director of APHA since 2002, he is leading the Association’s push to make America the healthiest nation in one generation. Expanded Bio: https://apha.org/about-apha/executive-board-and-staff/apha-staff/georges-c-benjamin-mdE. Oscar Alleyne, DrPH, MPH - Chief of Programs and Services, National Association of County and City Health Officials: Dr. E Oscar Alleyne is the Chief of Programs and Services for the National Association of County and City Health Officials, where he oversees its portfolio of programs, as well as its membership and meetings services. He directs the implementation of programs, promotion and diversification of funding and assists in raising NACCHO’s profile through external engagement and partnership development for the advancement of NACCHO’s mission and the success of the country’s almost-3,000 local health departments. He leads NACCHO’s national response efforts on emergent health threats such as COVID19, Zika, and natural disasters such as hurricanes. He is also responsible for personnel management and professional development; strategic planning; budget management; supervision of program leadership and services staff; and maintenance of subject matter knowledge of comprehensive policy issues that have an impact on local health departments and NACCHO. Dr. Alleyne began his career in governmental public health, designing software used as an expert system in guiding responses to adverse water quality events for the New York State Health Department. He joined Rockland County Health Department in New York at the beginning of the West Nile Virus outbreak, where he developed a model comprehensive educational and surveillance program.In his 15 years at Rockland County, Alleyne served as Director of Epidemiology and Public Health Planning responding to and mitigating several major emerging health issues including West Nile, Anthrax, Smallpox, Monkey Pox, H1N1, Botulism, MERS CoV, and Ebola. He also has experience as a Planning Section Chief for the Disaster Medical Assistance Team (NY4) under the federal National Disaster Medical System.He has an experienced and demonstrated history of working in the local and national public health sector. Skilled in Epidemiology, Health Communication, Population Health Planning and Assessment, Government, Emergency Preparedness, Informatics, Biosurveillance, and Environmental Health. In addition, Dr. Alleyne is the Past President of the Board of Directors of the New York State Public Health Association,Support the show (https://www.patreon.com/AMERIKANTHERAPY)

Lorenzo Norris, MD, spoke with Sheldon H. Preskorn, MD, about how to best educate patients about coronavirus. Dr. Preskorn is a professor in the department of psychiatry at the University of Kansas School of Medicine–Wichita. Neither Dr. Norris nor Dr. Preskorn have any relevant financial relationships to disclose. Take-home points Coronavirus 2019 (COVID-19) is the disease process caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).  SARS-CoV-2 is different from the previous SARS-type coronaviruses and is having a greater impact on society as a pandemic for three reasons: It’s highly transmissible person to person, it can be spread by infected individuals who are asymptomatic or presymptomatic, and it has a high level of morbidity but a lower level of mortality. Psychiatrists work with vulnerable populations, including older adults and individuals with medical comorbidities that put them at risk for COVID-19. Psychiatrists must understand the pertinent facts about COVID-19 to help their patients who are suffering the consequences of social distancing, a shuttered economy, and changes in their daily lives from COVID-19. Summary While coronaviruses are known to cause the common cold, some are more medically serious – and even lethal – based on their ability to cause a severe acute respiratory syndrome (SARS). SARS-CoV-2 is one in a line of several coronaviruses to make the leap from animals to humans and cause a severe acute respiratory syndrome with devastating effects. Previous coronaviruses include SARS-CoV-1, which caused an illness referred to as “SARS” that had a mortality rate close to a 10%, and MERS-CoV, which caused Middle East respiratory syndrome (MERS) and had an even higher mortality rate. The high mortality rate of these SARS-type coronaviruses is thought to be why they did not transition from epidemic to pandemic. SARS-CoV-2 is different from the previous SARS-type coronaviruses and is having a greater impact on society as a pandemic for three reasons: It’s highly transmissible from person to person, it can be spread by infected individuals who are asymptomatic or presymptomatic, and it has a high level of morbidity but a lower level of mortality. In terms of transmissibility, each person infected can infect up to six additional people and individuals can spread the virus even while asymptomatic or presymptomatic. This is why wearing a mask and engaging in social distancing are essential to slowing the spread of COVID-19. SARS-CoV-2 is more lethal than influenza and is especially dangerous for certain populations, such as older adults and those with multiple medical comorbidities, including chronic pulmonary obstructive disease, hypertension, diabetes, obesity, and being immunocompromised. In the United States, 80% of COVID-19 deaths are in people older than age 65 years. Psychiatrists must understand these pertinent facts about COVID-19 to help their patients who are suffering the consequences of social distancing, a shuttered economy, and changes in their daily lives from COVID-19. Psychotropic medications that can lead to metabolic syndrome, such as second-generation antipsychotics, may put patients with serious mental illness at risk of worse outcomes if infected with COVID-19. Ultimately, psychiatrists are medical doctors who are helping treat the secondary mental health effects of the COVID-19 pandemic, so we have a responsibility to have a working knowledge of the epidemiology and basic science of the virus to help our patients. References Preskorn SH. Coronavirus Disease 2019: The first wave and beyond. Psychiatr Times. 2020 Apr 28. Preskorn SH. COVID-19: Protecting the vulnerable and opening the economy. Psychiatr Times. 2020 May 6. Centers for Disease Control and Prevention. Coronavirus Disease 2019 (COVID-19). Older adults. National Institute of Allergy and Infectious Diseases. Coronaviruses. *  *  *   Show notes by Jacqueline Posada, MD, who is associate producer of the Psychcast and consultation-liaison psychiatry fellow with the Inova Fairfax Hospital/George Washington University program in Falls Church, Va.  Dr. Posada has no conflicts of interest. For more MDedge Podcasts, go to mdedge.com/podcasts Email the show: podcasts@mdedge.com  

Emmie de Wit joins TWiV to explain her work on the pathogenesis of infection with SARS-CoV-2 in rhesus macaques, including studies on remdesivir and vaccine candidate. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Guest: Emmie de Wit Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Respiratory disease in macaques inoculated with SARS-CoV-2 (Nature) Clinical benefit of remdesivir in SARS-CoV-2 infected macaques (bioRxiv) Remdesivir for MERS-CoV infection in macaques (PNAS) ChAdOX1 vaccination for SARS-CoV-2 in macaques (bioRxiv) Image credit Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Emmie de Wit joins TWiV to explain her work on the pathogenesis of infection with SARS-CoV-2 in rhesus macaques, including studies on remdesivir and vaccine candidate. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Guest: Emmie de Wit Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Respiratory disease in macaques inoculated with SARS-CoV-2 (Nature) Clinical benefit of remdesivir in SARS-CoV-2 infected macaques (bioRxiv) Remdesivir for MERS-CoV infection in macaques (PNAS) ChAdOX1 vaccination for SARS-CoV-2 in macaques (bioRxiv) Image credit Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In the last 17 years, there have been three new deadly coronavirus epidemics, but where do emerging diseases emerge from?

One investigational treatment being explored for COVID-19 is the use of convalescent plasma or CCP collected from individuals who have recovered from COVID-19. CCP that contains antibodies to severe acute respiratory syndrome coronavirus 2 or SARS-CoV-2 (the virus that causes COVID-19) is being studied for administration to patients with COVID-19. Use of convalescent plasma has been studied in outbreaks of other respiratory infections, including the 2003 SARS-CoV-1 epidemic, the 2009-2010 H1N1 influenza virus pandemic, and the 2012 MERS-CoV epidemic. Although promising, CCP has not yet been shown to be safe and effective as a treatment for COVID-19, explains Dr. Glen Ramsey, Medical Director of the Blood Bank at Northwestern Memorial Hospital in Chicago and Chair of the CAP Transfusion, Apheresis, and Cellular Therapy Committee. In this CAPcast, Dr. Ramsey provides a basic primer on CCP, as well as explains why it’s important to study the safety and efficacy of COVID-19 convalescent plasma in clinical trials and the blood bank’s role in providing CCP. Visit CAP.org's COVID-19 site for more updates related to pathologists and laboratory medicine: www.cap.org/covid-19.

Your daily COVID-19 LST Report: — Climate: A social media questionnaire of 270 men and 189 women in China found reduced sexual behaviors during the COVID-19 era. — Epidemiology: In a meta-analysis of 21 studies examining the incidence of gastrointestinal symptoms and liver injury in patients with COVID-19, researchers found that 9.1% of patients had diarrhea, 5.2% had nausea/vomiting, and 3.5% had abdominal pain. There was no significant difference in diarrhea or nausea/vomiting between severe and non-severe cases of COVID-19, and these symptoms did not have prognostic value. — Pathology: Researchers present a comprehensive review on SARS-CoV-2 immunopathology, describe putative mechanisms for cell-specific pathogenesis based on current research and studies on SARS-CoV and MERS-CoV. Notable mechanisms in pathogenesis include early interferon production and activation of NK cells as crucial steps to mitigate COVID-19 severity. — Management: Guidelines and recommendations for: Ethical allocation of scarce medications Managing seizure episodes Changing the delivery method of aerosolized medications Managing and treating acute kidney injury Coordinating rectal cancer treatment In a case series of 24 awake, hospitalized COVID-19 patients without mechanical ventilation, 15 tolerated prone positioning with 6 responding with more than 20% increase in partial pressure of arterial oxygen, leading the authors to recommend further studies to explore its efficacy. — Adjusting Practice: Guidelines and recommendations for practice during the pandemic:. Dental care, Control of infection in trauma surgery. Diagnosis, treatment, and monitoring of obstructive sleep apnea. Prioritization of surgical services. --- Support this podcast: https://anchor.fm/covid19lst/support

Wie unterscheiden sich die sieben bekannten humanpathogenen Coronaviren (CoV)? Was können wir aus der Impfstoffentwicklung gegen SARS-CoV-1 („classic SARS“) und MERS-CoV in Bezug auf SARS-CoV-2 lernen? Was muss ein Impfstoff, der gegen Covid-19 schützen soll, können? Welche der neuen Impfstoff-Technologien werden zur Zeit erprobt? Das sind einige der Fragen um die es in diesem zweiten … „Infektiopod#25 Spezial: Impfstoffentwicklung Teil 2“ weiterlesen

Susan Weiss recalls some of her 40 years of research on coronaviruses, including mouse hepatitis virus, MERS-CoV, and now SARS-CoV-2. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Susan Weiss Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Coronaviruses by Susan Weiss (YouTube) Forty years with coronaviruses (JEM) No credible evidence that SARS-CoV-2 came from a lab (Emerg Micr Infect) CoV and antagonism of RNAse L (mBio) Exoribonuclease needed for MHV innate antagonism (J Virol) RNAse L and ADAR (eLife) Emerging viruses respiratory award (Amer Lung Assoc) Image credit Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Susan Weiss recalls some of her 40 years of research on coronaviruses, including mouse hepatitis virus, MERS-CoV, and now SARS-CoV-2. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Susan Weiss Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Coronaviruses by Susan Weiss (YouTube) Forty years with coronaviruses (JEM) No credible evidence that SARS-CoV-2 came from a lab (Emerg Micr Infect) CoV and antagonism of RNAse L (mBio) Exoribonuclease needed for MHV innate antagonism (J Virol) RNAse L and ADAR (eLife) Emerging viruses respiratory award (Amer Lung Assoc) Image credit Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Crime: Google search on “Crime” and “News” Suicide, help hotline calls soar in Southern California over coronavirus anxieties Suicide, help hotline calls soar in Southern California over coronavirus anxieties Crisis Management: Beware of your message getting lost in the noise. How to take back the narrative. Change the frequency of the message Change the voice Change the format Coronavirus: Scientists have divided coronaviruses into four sub-groupings, called alpha, beta, gamma, and delta. Seven of these viruses can infect people. The four common ones are: 229E (alpha) NL63 (alpha) OC43 (beta) HKU1 (beta) The three less-common ones are: MERS-CoV, a beta virus that causes Middle East respiratory syndrome (MERS) SARS-CoV, a beta virus that causes severe acute respiratory syndrome (SARS) SARS-CoV-2, which causes COVID-19 https://www.webmd.com/lung/coronavirus-strains#1 Numbers: JHU - 17, 682 NYC - 17215 Security protection - ADT Criminals aren’t taking a Rona break Your Home Security https://bit.ly/351BsOo http://www.adtreferafriend.com/Register/accept/?EID=50ce7cc0-3a41-4596-9725-ea1ace9bfca7 "Royalty Free Music from Bensound"

In literally minute-by-minute, life and death situations, healthcare providers around the world are putting their own lives at risk as they answer the call to treat overwhelming numbers of Coronavirus patients. The situation is nowhere more challenging than in New York State, Long Island and here in Stony Brook, where medical professionals have been keeping pace with the surge day by day. On this episode of “Beyond the Expected," hosted by Interim President MIchael Bernstein, Stony Brook University Hospital attending physicians share their personal experiences of being infected by, and recovering from, COVID-19, in this environment, and Stony Brook University Hospital's Medical Director of Healthcare Epidemiology provides her expert opinions on how to stop the spread among patients and providers. Susan Donelan, MD, FSHEA, Medical Director, Healthcare Epidemiology Department; Hospital Epidemiologist; Assistant Professor, Infectious Diseases and Medical Director, Regional Training Center, MARO Region Susan Donelan has a strong clinical expertise in infectious diseases such as Lyme Disease and West Nile Virus, hospital-acquired infections, and MRSA. She has an interest in emerging infectious diseases, and her Ebola care plan is adaptable for patients who may have diseases like MERS-CoV and avian influenza. She has certified training in pandemic planning and preparedness, and trained for a week in Anniston, Alabama at the Center for Domestic Preparedness, with a certification in Healthcare Leadership and Decision Making. Dr. Donelan will share how all of this training and experience is being put to work in our current pandemic crisis to help prevent the occurrence, and spread, of COVID-19 among patients and the healthcare professionals treating them. Kimberly Noel, MD MPH, Stony Brook Medicine Telehealth Director; Deputy Chief Medical Information Officer; Patient Centered Medical Home Chief Quality Officer, Family Medicine; Occupational and Employee Health & Wellness Physician; Clinical Assistant Professor of Family, Population & Preventive Medicine Dr. Noel is a physician, published researcher, and telehealth specialist. She serves as the Director of Stony Brook Medicine Telehealth and the Deputy Chief Medical Information Officer and Chief Quality Officer of Family Medicine's PCMH. She devises telehealth strategy, implementation and policy solutions in collaboration with key stakeholders at Stony Brook and co-leads the Telehealth Workgroup, reporting to the Chief Information Officer. She is an occupational health physician, and practices clinically caring for Stony Brook employees. Beyond Stony Brook, Dr. Noel is an appointee to the New York State Department of Health Regulatory Modernization Initiative Telehealth Advisory Committee. She is leading a program for the American Telemedicine Association 2020 Conference for Telehealth Accessibility for persons with disabilities. James Vosswinkel, MD, FACS, Chief, Trauma, Emergency Surgery and Surgical Critical Care; Medical Director, Trauma Center Surgical ICU, Stony Brook Medicine; and Lillian and Leonard Schneider Endowed Professor in Trauma Surgery James “Voss” Vosswinkel's specialties include surgical management of injured patients in all aspects of traumatology. That includes management of diseases of the gastrointestinal and endocrine systems; treatment of soft tissue disease; repair of hernias; appendectomy; cholecystectomy; laparoscopic surgery; and pre- and post-operative critical care of adult surgical patients. Before and during this Coronavirus pandemic, he has been leading efforts to increase our Intensive Care Unit (ICU) capacity; collaborate with medical professionals locally, across the country and globally to share experiences and best practices; and develop innovative ways to treat patients in trauma under unimaginably challenging circumstances.

În acest episod povestim cu Dennis despre pandemia de coronavirus care a cuprins planeta în 2020. Introducerea și rezumatul au fost înregistrate în limba română. Pentru restul episodului am tradus transcriptul, pe care îl puteți găsi pe website-ul nostru: https://lenesxradio.ro/episodes/-01/lenesx--01-covid-RO.html ====== Cuprins Partea 0 - Introducere (3:08) Partea 1 - Ce este acest "SARS-CoV-2"? (6:06) Pauză 1 - Demistificare (37:26) Partea 2 - Statistici, modele și metode de prevenție (43:53) Pauză 2 - Lorem Ipsum Sloth Dolor Amet (1:12:48) Partea 3 - Capitalismul este adevăratul virus (1:14:53) Sumar (1:54:41) ====== În acest episod vorbim cu Dennis, tovarăș medicinist și antifascist, despre pandemia curentă de SARS-CoV-2/COVID-19. În prima parte a discuției Dennis ne vorbește despre ce este și cum acționează un virus, despre originea și caracteristicile făptașului curent, despre parametrii de urmărit în cazul unei pandemii, respectiv cum se compară SARS-CoV-2 cu alte epidemii recente (SARS-CoV:2002-2004, MERS-CoV:2012-prezent). În partea a 2-a căutăm să înțelegem starea actuală a lucrurilor, care sunt grupurile cele mai vulnerabile în fața bolii (COVID-19) și care sunt principalele moduri de prevenție. În ultima parte dezbatem răspunsurile autoritare ale guvernelor în fața acestei crize și rolul sistemului-lume capitalist în producerea și amplificarea acestei pandemii. Notă importantă: acest episod a fost înregistrat pe 27 martie, 2020. Întrucât cercetarea evoluează constant iar situația politică e în continuă schimbare, unele dintre lucrurile discutate aici ar putea deveni inexacte sau depășite în câteva săptămâni sau luni. ====== (Re)Surse Articol de la Imperial College of London: https://www.imperial.ac.uk/media/imperial-college/medicine/sph/ide/gida-fellowships/Imperial-College-COVID19-NPI-modelling-16-03-2020.pdf Critică la articolul de mai sus: https://necsi.edu/review-of-ferguson-et-al-impact-of-non-pharmaceutical-interventions Date și metrici despre pandemie: https://www.worldometers.info/coronavirus/ Harta John Hopkins a COVID-19: https://coronavirus.jhu.edu/map.html Piesa de la intro/outro de Sofia Zadar: https://www.facebook.com/sofiazadar/ https://www.youtube.com/watch?v=u7Kf0rkIhTM https://open.spotify.com/artist/3F4Ec4iFdVp4Pmzhw2Zrd1 ====== Urmăriți-ne pe: https://www.facebook.com/lenesxradio https://instagram.com/lenesxradio https://twitter.com/lenesxradio https://www.tiktok.com/@lenesxradio https://www.youtube.com/channel/UC2eulSthPuUPvVldCvpnZlg Contactați-ne prin: lenesxradio@protonmail.com

In this episode we welcome Shelda Holmes, the medical director of Hands on Medicine who tells us what it's like for frontline medical responders during a global pandemic. We talk about how the virus spreads, what we know and don't know, the struggle of individualism vs public health, and the lack of PPE. Shelda shares with us her personal struggles when making decisions that can put her staff at risk, why N95 masks are important for medical staff, and why isolation works to flatten the curve. The big message - stay at home! COVID-19 is caused by a coronavirus. Coronaviruses are a large family of viruses that are common in people and many different species of animals, including camels, cattle, cats, and bats. Rarely, animal coronaviruses can infect people and then spread between people such as with MERS-CoV, SARS-CoV, and now with this new virus (named SARS-CoV-2).The SARS-CoV-2 virus is a betacoronavirus, like MERS-CoV and SARS-CoV. All three of these viruses have their origins in bats. The sequences from U.S. patients are similar to the one that China initially posted, suggesting a likely single, recent emergence of this virus from an animal reservoir.To apply to work with us, or more information on Being UnNormal check out our website at www.beingunnormal.comFollow us on social media!Facebook: https://www.facebook.com/beingunnormalInstagram: https://www.instagram.com/beingunnormalpodcastSupport the show (http://www.pateron.com/beingunnormal)

[RO] În acest episod povestim cu Dennis despre pandemia de coronavirus care a cuprins planeta în 2020. Puteți găsi un transcript integral al episodului (tradus) pe website: https://lenesxradio.ro/episodes/-01/lenesx--01-covid-RO.html [EN] In this episode we sit down to talk with Dennis about the coronavirus pandemic that has engulfed our planet in 2020. You can find a full transcript of the episode on our website: https://lenesxradio.ro/episodes/-01/lenesx--01-covid-EN.html ====== Cuprins / Table of Contents Part 0 - Introduction (2:58) Part 1 - What is this "SARS-CoV-2"? (5:56) Break 1 - Debunking some myths (37:16) Part 2 - Statistics, models and methods of prevention (43:43) Break 2 - Lorem Ipsum Sloth Dolor Amet (1:12:38) Part 3 - Capitalism is the real virus (1:14:43) Summary (1:54:31) ====== [RO] În acest episod vorbim cu Dennis, tovarăș medicinist și antifascist, despre pandemia curentă de SARS-CoV-2/COVID-19. În prima parte a discuției Dennis ne vorbește despre ce este și cum acționează un virus, despre originea și caracteristicile făptașului curent, despre parametrii de urmărit în cazul unei pandemii, respectiv cum se compară SARS-CoV-2 cu alte epidemii recente (SARS-CoV:2002-2004, MERS-CoV:2012-prezent). În partea a 2-a căutăm să înțelegem starea actuală a lucrurilor, care sunt grupurile cele mai vulnerabile în fața bolii (COVID-19) și care sunt principalele moduri de prevenție. În ultima parte dezbatem răspunsurile autoritare ale guvernelor în fața acestei crize și rolul sistemului-lume capitalist în producerea și amplificarea acestei pandemii. Notă importantă: acest episod a fost înregistrat pe 27 martie, 2020. Întrucât cercetarea evoluează constant iar situația politică e în continuă schimbare, unele dintre lucrurile discutate aici ar putea deveni inexacte sau depășite în câteva săptămâni sau luni. [EN] In this episode we speak with Dennis, a medical student and antifascist comrade, about the current SARS-CoV-2/COVID-19 pandemic. In the first part of the discussion, Dennis tells us what a virus is and how it operates, about the origin and characteristics of the current culprit, about the parameters to look for in order to understand a pandemic, and how SARS-CoV-2 compares with other recent pandemics (SARS-CoV:2002-2004, MERS-CoV:2012-present). In the next section we learn about the current state of the world, about which groups are most vulnerable to the disease (COVID-19), and about the main modes of prevention. In the last part we debate the authoritarian response of governments and the role of the capitalist world-system in the production and amplification of this pandemic. Important note: this episode was recorded on March 27th, 2020. At the moment, things are changing constantly, sometimes from one day to the next. Ongoing research and changes in the political situation may render some of the information discussed here obsolete or outdated, within weeks or months. ====== (Re)Sources Imperial College of London paper: https://www.imperial.ac.uk/media/imperial-college/medicine/sph/ide/gida-fellowships/Imperial-College-COVID19-NPI-modelling-16-03-2020.pdf A critical review of the above paper: https://necsi.edu/review-of-ferguson-et-al-impact-of-non-pharmaceutical-interventions Pandemic data and metrics: https://www.worldometers.info/coronavirus/ John Hopkins COVID-19 case-tracker map: https://coronavirus.jhu.edu/map.html Intro/Outro song by Sofia Zadar: https://www.facebook.com/sofiazadar/ https://www.youtube.com/watch?v=u7Kf0rkIhTM https://open.spotify.com/artist/3F4Ec4iFdVp4Pmzhw2Zrd1 ====== Follow us on: https://www.facebook.com/lenesxradio https://instagram.com/lenesxradio https://twitter.com/lenesxradio https://www.tiktok.com/@lenesxradio https://www.youtube.com/channel/UC2eulSthPuUPvVldCvpnZlg Contact us at: lenesxradio@protonmail.com

Show notes: In the show, The Bio Busters professors, Dr. A and Dr. C and Dr. K, discuss the ongoing coronavirus pandemic. The winner for last episode's Guess the Microbe is Rick Lorenzo. Keep the discussion and comments going on the iTunes review section, or feel free to e-mail the podcast with future show ideas and thoughts on the current show. Music by Bahaa Naamani Email us at thebiobusters@gmail.com References: Update on Mask Debate and Aerosolization https://www.livescience.com/coronavirus-do-face-masks-work.html CDC analysis of At-Risk Groups https://www.npr.org/sections/coronavirus-live-updates/2020/03/31/824846243/whos-sickest-from-covid-19-these-conditions-tied-to-increased-risk Comparing SARS1 to COVID-19 https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(20)30129-8/fulltext MERS Summary https://www.niaid.nih.gov/diseases-conditions/covid-19 New Method of COVID-19 Detection in Wastewater https://www.bloomberg.com/news/articles/2020-03-31/coronavirus-in-sewage-portended-covid-19-outbreak-in-dutch-city Updates on Grocery Shopping in the COVID-19 Pandemic https://www.sciencealert.com/food-safety-expert-explains-how-to-safely-deal-with-groceries-during-the-pandemic Compare SARS-coV-1 to MERS-coV to SARS-coV-2 (or COVID-19) https://www.businessinsider.com/coronavirus-compared-to-sars-swine-flu-mers-zika-2020-3

Experts believe COVID-19 is a zoonotic disease that originated in animals before it was transmitted to humans. Bats are believed to have been the source of COVID-19, as well as some other deadly zoonotic disease outbreaks like MERS-CoV and SARS. We hear from Oregon State University professor and veterinarian Christiane Löhr about how infectious diseases can jump from animals to humans.

Esté atento a los síntomas Los casos confirmados de la enfermedad del coronavirus 2019 (COVID-19) reportan síntomas que varían de leves a enfermedad grave y muerte. Estos síntomas pueden aparecer 2 a 14 días después de la exposición (con base en la información sobre periodos de incubación de los virus MERS-CoV). Fiebre Tos Dificultad para respirar --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/thewinners/message Support this podcast: https://anchor.fm/thewinners/support

Clionix şirketinin partnerlerinden Arda Karaduman ile birlikte ilaç ve medikal cihazlarda regülasyon konusunda bilgi dolu bir bölüm çektik. Yayın sırasında bahsi geçen başlıklara dair bilgileri aşağıdaki linklerde bulabilirsiniz: Klinik araştırmalar veritabanı: https://clinicaltrials.gov/ FDA: https://www.fda.gov/ EMA: https://www.ema.europa.eu/en Covid-19 ile ilgili klinik araştırmaları süren ilaçlar: link Corona virüs ile ilgili patent eğilimleri ve patent sahipleri-interaktif veri-: https://www.patenteffect.com/corona MERS-CoV ve SARS-CoV patent eğilim grafiği: link ------ Bu günler de geçecek! #evdekal Bizi Apple podcast, Spotify ve Google Podcast'ten dinleyebilirsiniz. Patent Effect'i Twitter ve Linkedin hesaplarından takip etmeyi unutmayın:) // www.patenteffect.com //

Welcome to the health frontiers radio show and podcast where our goal each week is to empower our listeners to become the champions of their health and their future through education and proper supplementation.   Health Frontiers Radio COVID-19 Pandemic Update and Live Q&A On March 11, COVID-19 was officially declared a pandemic by the World Health Organization, and it is proving to be much more disruptive and deadly than originally thought. Join the Health Frontiers Broadcast team for a live Q&A session as we review what is known about the virus, symptoms, treatments and prevention strategies that will serve you well in strengthening your resistance to viral or microbial threats. Reported illnesses have ranged from very mild (including some with no reported symptoms) to severe, including illness resulting in death. While information so far suggests that most COVID-19 illness is mild, a recent report out of China suggested that serious illness occurs in 16% of cases. Older people and people of all ages with severe chronic medical conditions — like heart disease, lung disease, and diabetes, for example — seem to be at higher risk of developing serious COVID-19 illness. A CDC Morbidity & Mortality Weekly Report that looked at the severity of disease among COVID-19 cases in the United States by age group found that 80% of deaths were among adults 65 years and older with the highest percentage of severe outcomes occurring in people 85 years and older. The CDC’s recent (2/25) warning regarding the emerging threat of a COVID-19 outbreak in the US was chilling indeed: “It is not a matter of if, but when it will spread in US communities, and Americans should prepare for “significant disruption” to their lives as a result”. The world is anxiously watching the progression of this new virus which is already having far-reaching implications on our economy, travel, schools, and politics. What is a coronavirus? Coronaviruses are a large family of viruses (including the common cold) so named because of the crown-like features on their surface. The new COVID-19 virus was first detected in the Chinese city of Wuhan in December 2019 and has since spread globally. According to the Centers for Disease Control and Prevention, these first reported cases had links to a live animal market, suggesting the outbreak started from animal-to-person spread. Coronaviruses are responsible for two other recent outbreaks: the 2003 SARS (severe acute respiratory syndrome) outbreak and the 2012 MERS (Middle East Respiratory Syndrome) outbreak. Latest Data on Outbreak As of March 20th, the number of confirmed cases worldwide was 254,996 and total deaths numbered 10,415 with 87,351 recovered. The virus outbreak seems to be most intense now in Western Europe, and the US has taken unprecedented steps to try to slow down transmission including the temporary closing of schools, restaurants, bars, malls, fitness centers and suspended public meetings of large groups, athletic events, etc. Johns Hopkins University has created a real-time data tracking web page to track confirmed global COVID-19 cases which may be viewed by clicking this link: https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6 What are the symptoms? How does it spread? Patients with COVID-19 experience mild to severe respiratory illnesses. Symptoms include fever, cough, and difficulty breathing and can appear two to 14 days after exposure, according to the CDC. Around 80 percent of confirmed Chinese cases were mild, the New York Times reported, and the overall fatality rate is around 2.3% in China. Comparatively, the seasonal flu has a mortality rate of about 0.1 percent. The coronavirus mainly spreads from human to human. Like the common cold, the virus is transmitted when a person coughs or sneezes. It's also possible that a person can get COVID-19 by touching a surface with the virus on it before touching their mouth, face or eyes. For confirmed coronavirus disease 2019 (COVID-19) cases, reported illnesses have ranged from mild symptoms to severe illness and death. Symptoms can include: Fever Cough Shortness of breath CDC believes at this time that symptoms of COVID-19 may appear in as few as 2 days or as long as 14 days after exposure. This is based on what has been seen previously as the incubation period of MERS-CoV viruses. Q: Am I at risk for COVID-19 from a package or product shipping from China? A: There is still a lot that is unknown about the newly emerged COVID-19 and how it spreads. Two other coronaviruses have emerged previously to cause severe illness in people (MERS-CoV and SARS-CoV). While we don’t know for sure that this virus will behave the same way as SARS-CoV and MERS-CoV, we can use the information gained from both of these earlier coronaviruses to guide us. In general, because of poor survivability of these coronaviruses on surfaces, there is likely a very low risk of spread from products or packaging that are shipped over a period of days or weeks at ambient temperatures. Coronaviruses are generally thought to be spread most often by respiratory droplets. Currently, there is no evidence to support the transmission of COVID-19 associated with imported goods and there have not been any cases of COVID-19 in the United States associated with imported goods. The latest information will be provided on the Coronavirus Disease 2019 (COVID-19) website as it becomes available.  Prevention The best way to prevent illness is to avoid being exposed to this virus. However, as a reminder, the CDC always recommends everyday preventive actions to help prevent the spread of respiratory diseases, including: Avoid close contact with people who are sick. Avoid touching your eyes, nose, and mouth. Stay home when you are sick. Cover your cough or sneeze with a tissue, then throw the tissue in the trash. Clean and disinfect frequently touched objects and surfaces using a regular household cleaning spray or wipe. Follow CDC’s recommendations for using a facemask. CDC does not recommend that people who are well wearing a facemask to protect themselves from respiratory diseases, including COVID-19. Facemasks should be used by people who show symptoms of COVID-19 to help prevent the spread of the disease to others. The use of facemasks is also crucial for health workers and people who are taking care of someone in close settings(at home or in a health care facility). Wash your hands often with soap and water for at least 20 seconds, especially after going to the bathroom; before eating; and after blowing your nose, coughing, or sneezing. If soap and water are not readily available, use an alcohol-based hand sanitizer with at least 60% alcohol. Always wash hands with soap and water.   In addition to these avoidance/prevention strategies, the key to surviving and thriving in the face of emerging viral and microbial threats is to do all you can to maximize your health, vitality and natural resistance with a strong and balanced immune system: Eat a balanced diet of wholesome foods - meats, grains, fruits, nuts, and especially vegetables. Avoid refined carbs and processed foods, carbonated sodas, unfermented soy products, and GMO grains. Stay hydrated by drinking pure filtered water. Get adequate rest and regular moderate exercise. Take supplements to strengthen organs and detoxification systems, improve digestion, lower inflammation and oxidative stress, and maximize cellular energy potential… which is exactly what the Burgstiner Wellness Protocol is designed to do.  Use discount code GREATHEALTH at checkout to save 10% on your order total. Take supplements that strengthen immunity and help support natural resistance during cold and flu season such as Immunotabs Organic Immune Support, Colostrum, Complete Thymic Formula, Vitamin D3, Vitamin C, and Monolaurin.  Use discount code GREATHEALTH at checkout to save 10% on your order total. Could the old generic malaria drug hydroxychloroquine (Plaquenil, Sanofi-Aventis, among others), which is also used for the treatment of rheumatic disease, be an essential treatment for COVID-19? This hypothesis, put forward by some, including Professor Didier Raoult of the IHU Méditerranée Infection in Marseille, was dismissed by other eminent infectious disease specialists and dismissed as fake news recently by the Ministry of Health. Yet it resurfaced yesterday with the presentation on YouTube by Prof Raoult of positive results in a non-randomized, unblinded trial of 24 patients. This follows encouraging in vitro results obtained by a Chinese team led by Xueting Yao, from Peking University Third Hospital, Beijing, China, which were published online by the journal Clinical Infectious Diseases on March 9th. However, the data were deemed insufficient by the infection community to recommend the compound as a treatment. Moreover, chloroquine is not listed among the four treatments studied as part of the recently launched European clinical trial piloted by Inserm, which includes 3200 severe hospitalized patients, including 800 French patients. Chloroquine was ruled out due to the risk of interactions with other medications for common comorbidities in infected patients, and because of possible adverse effects in patients undergoing resuscitation. The Marseille Study The European Union Clinical Trials Register shows that the Marseille study was accepted on 5th March by the National Medicines Safety Agency (ANSM). It could include up to 25 COVID-19 positive patients, comprising five aged 12–17 years, 10 aged 18–64 years, and 10 more aged 65 years or over. While the data have not yet been published, and should, therefore, be interpreted with caution, this non-randomized, unblinded study showed a strong reduction in viral load with hydroxychloroquine. After 6 days, the percentage of patients testing positive for COVID-19 who received hydroxychloroquine fell to 25% versus 90% for those who did not receive the treatment (a group of untreated COVID-19 patients from Nice and Avignon). In addition, comparing untreated patients, those receiving hydroxychloroquine and those given hydroxychloroquine plus the antibiotic azithromycin, the results showed there was "a spectacular reduction in the number of positive cases" with the combination therapy, said Prof Raoult. At 6 days, among patients given combination therapy, the percentage of cases still carrying SRAS-CoV-2 was no more than 5%. Call Al Fusco for Nutritional and Functional Medicine Advice and Wellness Strategies and Assessment:  949.436.0934 

VRS, MERS-Cov, SRAS-Cov ... Covid-19 texte issu du Pilly 2020 page 474 https://www.infectiologie.com/UserFiles/File/formation/ecn-pilly-2020/ecn-2020-ue6-172-nb.pdf https://www.infectiologie.com/fr/ecnpilly-edition-2020-disponible-en-librairie.html https://epopi.fr/ouvrages-du-CMIT.php fabienne.feuillade@alineaplus.fr

A new coronavirus was discovered in late 2019 after an outbreak in Wuhan, China. Coronaviruses are a large family of diseases ranging from the common cold to MERS-CoV and SARS-CoV. This new virus, COVID-19, has since spread to several countries and is considered a global pandemic. In today’s bonus episode, Dr. Jockers fills you in on how you can protect yourself from contracting the virus. Tune in to learn more about COVID-19, its symptoms, and how you can prevent infection. Dr. Jockers encourages a proactive approach, so get ready to take action!    “Your immune system is a muscle.” - Dr. Jockers    Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean TuneIn Radio   In This Episode:   - What is a virus and how does it work?   - Understanding COVID-19   - Five lifestyle activities that cripple your immune system   - Top ways to prevent a coronavirus infection   - Use coupon code JOCKERS10 to save on your Dr. Jockers Store purchases     Resources:   - Check out the YouTube video here –  https://www.youtube.com/watch?v=Eq1JoDgpsjE   - ImmunoStrong - https://store.drjockers.com/products/immunostrong-berry-liquid?variant=28887571333168   - Allertrex – https://www.amazon.com/Global-Healing-Center-Allertrex-Fl/dp/B00B1ZPMMO    Connect with Dr. Jockers:   - Instagram – https://www.instagram.com/drjockers/   - Facebook – https://www.facebook.com/DrDavidJockers   - YouTube – https://www.youtube.com/user/djockers   - Website – https://drjockers.com/  

Coronaviruses (CoV) are a large family of viruses that cause illness ranging from the common cold to more severe diseases such as Middle East Respiratory Syndrome (MERS-CoV) and Severe Acute Respiratory Syndrome (SARS-CoV). Coronavirus disease (COVID-19) is a new strain that was discovered in 2019 and has not been previously identified in humans. Coronaviruses are zoonotic, meaning they are transmitted between animals and people. Detailed investigations found that SARS-CoV was transmitted from civet cats to humans and MERS-CoV from dromedary camels to humans. Several known coronaviruses are circulating in animals that have not yet infected humans. Common signs of infection include respiratory symptoms, fever, cough, shortness of breath and breathing difficulties. In more severe cases, infection can cause pneumonia, severe acute respiratory syndrome, kidney failure and even death. Standard recommendations to prevent infection spread include regular hand washing, covering mouth and nose when coughing and sneezing, thoroughly cooking meat and eggs. Avoid close contact with anyone showing symptoms of respiratory illness such as coughing and sneezing. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/wafiqbhai/message

On this episode of BowHunterPlanet we chat about - Coronavirus the UNTOLD TRUTH! Coronaviruses (CoV) are a large family of viruses that cause illness ranging from the common cold to more severe diseases such as Middle East Respiratory Syndrome (MERS-CoV) and Severe Acute Respiratory Syndrome (SARS-CoV). A novel coronavirus (nCoV) is a new strain that has not been previously identified in humans. Coronaviruses are zoonotic, meaning they are transmitted between animals and people. Detailed investigations found that SARS-CoV was transmitted from civet cats to humans and MERS-CoV from dromedary camels to humans. Several known coronaviruses are circulating in animals that have not yet infected humans. Common signs of infection include respiratory symptoms, fever, cough, shortness of breath and breathing difficulties. In more severe cases, infection can cause pneumonia, severe acute respiratory syndrome, kidney failure and even death. Standard recommendations to prevent infection spread include regular hand washing, covering mouth and nose when coughing and sneezing, thoroughly cooking meat and eggs. Avoid close contact with anyone showing symptoms of respiratory illness such as coughing and sneezing. Support BHP - Donate now to keep BHP doing what you love. http://bit.ly/PatGAc ---------REGISTER ------------------------------------------ ALL NEW website - http://bit.ly/BhpNewWebsite Register now to win great gear - http://bit.ly/BhPrEgistry ------ FOLLOW BHP ----------------------------------------- -Subscribe to BHP http://bit.ly/2Djy5Tl -Follow us on Instagram: http://bit.ly/2tAEqu3 -Follow us on Facebook: http://bit.ly/2FBdNa4 -Follow us on Twitter: http://bit.ly/bhptwit ------BHP MERCH----------------------------------------------- STORE - http://bit.ly/BHPSHOP Get 10% off use Code: ILOVEBHP Get 20% join TEAMBHP - http://bit.ly/amb_bhp youtube Custom SWAG STORE: http://bit.ly/2OgDaGM --------LETSGOLIVE---------------------------------------------- -Book a Live testlab Show! email us at info@bowhunterplanet.com -------BHPMEDIA ------------------------------------------------ Video/Photos: BHP MEDIA - http://bit.ly/_BHP -------JOINTEAMBHP-------------------------------------------- -Join the Ambassador Program - http://bit.ly/TEAMBHP_ -------BHP PODCAST--------------------------------------------- -Listen to the BHP PODCAST - http://bit.ly/2FH8QzM -ITUNES - http://bit.ly/BHPpodcast -SoundCloud - http://bit.ly/Sdcloudbhp

Medien berichten von Ausnahmezuständen, leeren Supermärkten und Katastrophenszenarien. Doch wie gefährlich ist dieser Virus tatsächlich? Können wir uns vor einer Infektion schützen? In dieser Episode gehen wir der Sache physiologisch und immunologisch auf den Grund, sprechen über effektive Wege das Immunsystem zu stärken und beantworten Fragen aus unserer Community.  Online-Akademie:  -35% Rabattcode Darm-Regeneration: "CORONA"  Wenn Du uns auch eine Frage stellen möchtest, schreibe uns auf: support@evolve-health.de Mehr Informationen findest du unter:  www.evolve-health.de   Quellen:  Mahallawi, Waleed et.al. (2018); MERS-CoV infection in humans is associated with a pro-inflammatory Th1 and Th17 cytokine profile; 104. 8-13. 10.1016/j.cyto.2018.01.025. Duvall MG et.al. (2016), DHA- and EPA-derived resolvins, protectins, and maresins in airway inflammation; Eur J Pharmacol. 2016 Aug 15;785:144-155 Roxas M1, Jurenka J. (2007), Colds and influenza: a review of diagnosis and conventional, botanical, and nutritional considerations. Altern Med Rev.2007 Mar;12(1):25-48 https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds) https://www.sozialministerium.at/Informationen-zum-Coronavirus/Neuartiges-Coronavirus-(2019-nCov).html https://link.springer.com/article/10.1007/s001290050569

Written by Dr. Paul Meier: LEADING CAUSES OF DEATH PER YEAR IN THE USA: HEART DISEASE = 635,000CANCER = 600,000ACCIDENTS OF ALL KINDS THAT ARE UNINTENTIONAL = 161,000RESPIRATORY DISEASE = 155,000STROKE = 142,000ALZHEIMERS = 116,000DIABETES = 80,000OPIOID OVERDOSES = 65,000THE FLU AND PNEUMONIA = 52,000KIDNEY DISEASE = 50,000SUICIDE = 45,000SEPTICEMIA (BACTERIAL INFECTIONS IN THE BLOODSTREAM) = 40,000LIVER DISEASE AND CIRRHOSIS = 38,000MURDERS = 16,000DEATHS IN FIRST TWO MONTHS OF CORONAVIRUS IN THE USA = 0 CORONAVIRUSESTHERE ARE MANY CORONAVIRUS ILLNESSES, INCLUDING THE COMMON COLD. PREVENTION OF CORONAVIRUS: Standard recommendations to prevent infection spread include regular hand washing, covering mouth and nose when coughing and sneezing, thoroughly cooking meat and eggs. Avoid close contact with anyone showing symptoms of respiratory illness such as coughing and sneezing THE CDC SAID THAT THE US SHOULD PREPARE FOR A LIKELY EPIDEMIC AND LIMIT AIR TRAVEL AND LARGE GROUPS OF PEOPLE. HAVE BUSINESS MEETINGS BY SKYPE RATHER THAN FLYING TO A CENTRALIZED LOCATION. COLLEGES MAY DIVIDE THEIR STUDENTS INTO SMALLER CLASSES, OR, IF IT BECOMES SEVERE ENOUGH, QUIT USING CLASSES ALTOGETHER AND HAVE CLASSES ONLINE. SYMPTOMS OF CORONAVIRUS: Common signs of infection include respiratory symptoms, fever, cough, shortness of breath and breathing difficulties. In more severe cases, infection can cause pneumonia, severe acute respiratory syndrome, kidney failure and death. Coronaviruses are zoonotic, meaning they are transmitted between animals and people. Detailed investigations found that SARS-CoV was transmitted from civet cats to humans and MERS-CoV from dromedary camels to humans.SARS is Severe Acute Respiratory Syndrome Coronavirus and spread around the world in 2003. It caused flu-like symptoms. SARS has a death rate of 15% overall, but people 65 and over have a much higher death rate. MERS (Middle East Respiratory Syndrome Coronavirus) has a death rate of 35%.MERS: Middle East respiratory syndrome (MERS) is a viral respiratory disease caused by a novel coronavirus (Middle East respiratory syndrome coronavirus, or MERS‐CoV) that was first identified in Saudi Arabia in 2012, but is most prevalent in Jordan, the United Arab Emirates, and South Korea. Typical MERS symptoms include fever, cough and shortness of breath. Pneumonia is common, but not always present. Gastrointestinal symptoms, including diarrhea have also been reported. Some people test positive for MERS without ever having any symptoms but can still pass it along.ATLANTA- Two hundred travelers coming through Atlanta's airport recently showed potential symptoms connected to the new virus that is spreading around the globe and were designated for home quarantine.CORONAVIRUS CAN LIVE ON SURFACES FOR UP TO 9 DAYS, SCIENTISTS SAY. ON 2.25.20, THE CDC REPORTED THAT THE CORONAVIRUS IS PROBABLY GOING TO BECOME AN EPIDEMIC IN THE UNITED STATES AND IS ALREADY SPREADING TO MANY STATES.SCIENTISTS ESTIMATE THAT, IN A WORST-CASE SCENARIO, UP TO 70% OF THE WORLD POPULATION COULD BECOME INFECTED WITH CORONAVIRUS. THERE ARE 8.6 BILLION PEOPLE IN THE WORLD, SO THAT WOULD BE APPROXIMATELY 6 BILLION INFECTED. IF THE DEATH RATE TURNS OUT TO BE 5%, FOR EXAMPLE, THEN 300 MILLION PEOPLE WOULD DIE.CORONAVIRUS, designated COVID-19, SPREADS MORE EASILY THAT OTHER CORONAVIRUS ILLNESSES LIKE SARS OR MERS. it has not yet proven to be as deadly as its related coronavirus strands, but we don’t really know what the death rate will end up being after we get more extensive and accurate reporting. China claims only a 2.3% death rate, but there are many reasons why Chinese politicians would report a lower death rate than what is factual. Iran reports a death rate of 20%. Some time in 2020, we will have a much better idea of the actual death rate and how it compares to SARS (15% death rate) and MERS (35% death rate). LIFE IS WHAT HAPPENS WHILE WE ARE BUSY MAKING OTHER PLANS. IN ITALY RIGHT NOW, WITH A NUMBER OF DEATHS ALREADY FROM CORONAVIRUS, THERE IS MUCH PANIC AND MANY GROCERY STORES ARE EMPTY AS PEOPLE PURCHASE FOOD TO STORE IF THEY HAVE TO REMAIN IN THEIR HOMES. IT WOULD BE WISE TO PLAN AHEAD AND MAKE PREPARATIONS IF PROPORTION TO THE ACTUAL THREAT AT THE TIME, BUT WITHOUT PANIC. WHATEVER HAPPENS IN REGARD TO THIS WORLDWIDE PANDEMIC, LIFE WILL CONTINUE TO GO ON AND SCIENTISTS WILL CONQUER THIS DISEASE LIKE THEY HAVE MOST OTHER ONES—WE HOPE—EVEN THOUGH SCIENTISTS HAVE NOT YET FOUND A CURE FOR THE COMMON COLD, ANOTHER MILDER CORONAVIRUS. UPDATE AS OF 3.12.20: YESTERDAY, ON THE ADVISE OF THE USA CORONAVIRUS TEAM OF THE CDC, WHO, JOHNS HOPKINS UNIV MED SCHOOL INFECTION SPECIALISTS AND RESEARCHERS, AND OTHER SCIENTISTS, THE ADMINISTRATION ANNOUNCED A 30 DAY TRAVEL BAN ON EUROPE OTHER THAN THE UK (SINCE THE UK ENFORCED QUICK TRAVEL BANS WHEN THE VIRUS WAS DISCOVERED, AS DID THE USA, SO THE INCIDENCE IN THOSE TWO COUNTRIES IS RELATIVELY LOW, WHILE EUROPE DID NOT DO TRAVEL BANS TO AND FROM CHINA AND OTHER DANGEROUS PLACES AND HAVE WIDESPREAD CORONAVIRUS. THE WHO ANNOUNCED THAT IT IS OFFICIALLY A PANDEMIC, WHICH JUST MEANS IT IS PRESENT IN MANY COUNTRIES AND THE NUMBER CONTINUES TO INCREASE. AS OF TODAY, THE AVERAGE DEATH AGE IN THE USA OF THOSE RELATIVELY FEW WHO HAVE DIED IS 80 YEARS OLD AND NOBODY UNDER 30 HAS DIED OF IT. PEOPLE 65 AND OLDER ARE MORE VULNERABLE, ESPECIALLY IF THEY HAVE SIGNIFICANT MEDICAL CONDITIONS, SO RETIREMENT HOMES ARE ESPECIALLY BEING OBSERVED. MANY OF THE INFECTION CONTROL DOCS RECOMMEND THAT THE ELDERLY AVOID CROWDED PLACES OF 250 PEOPLE OR MORE, AVOID TRAVEL ON AIRLINES OR ESPECIALLY CRUISES, AND NOT ATTEND LARGE EVENTS LIKE SPORTING EVENTS. THE NBA SUSPENDED GAMES FOR NOW. THE NCAA FINAL FOUR WILL BE PLAYED ON TV WITH NO SALES THE TO PUBLIC. JUST THE COACHES AND SOME OF THEIR CLOSE RELATIVES OR ASSOCIATES CAN ATTEND. POLITICAL RALLIES HAVE BEEN TEMPORARILY SUSPENDED. MORE PEOPLE, ESPECIALLY THE ELDERLY, WILL ATTEND CHURCH OR OTHER ACTIVITIES ONLINE RATHER THAN IN CROWDS. THE DEATH RATE FROM CORONAVIRUS IN THE USA IS NOT YET DETERMINED BUT IS LIKELY TO END UP AROUND THE 2% RANGE BUT ALMOST EXCLUSIVELY IN THE ELDERLY. THE DEATH RATE FROM THE COMMON FLU IS 0.1% BUT THE FLU CAN KILL ANY AGE GROUP AND THERE CAN BE 40,000 A YEAR WHO DIE PER YEAR OF THE FLU IN THE USA AND WE JUST EXPECT IT AND ACCEPT IT. THE FLU IS SPREAD TO AN AVERAGE OF 1.5 PEOPLE PER FLU VICTIM BUT THE CORONAVIRUS IS MORE TRANSMITTABLE AND CAN EVEN STAY ALIVE ON HARD SURFACES LIKE GLASS OR METAL FOR ABOUT A WEEK—POSSIBLY 9 DAYS MAX. IT IS RECOMMENDED TO WASH OUR HANDS SEVERAL TIMES A DAY WITH SOAP FOR TWENTY SECONDS OR LONGER. DON’T COUGH WITHOUT COVERING YOUR MOUTH AND STAY AWAY FROM PEOPLE WHO ARE COUGHING. THE SYMPTOMS OF CORONAVIRUS IN THE YOUNG ARE USUALLY MUCH LESS THAN THE COMMON FLU. WITH CORONAVIRUS, THERE IS RARELY ANY NAUSEA, VOMITING OR MUSCLE ACHES LIKE THERE ARE WITH THE FLU—USUALLY JUST COUGHING AND A FEVER, AND SOMETIMES SOME SHORTNESS OF BREATH. SEVERE CASES PROGRESS TO PNEUMONIA AND POTENTIAL DEATH IN THOSE OVER 30 AND ESPECIALLY 65 OR OLDER. GREAT EFFORTS ARE BEING MADE IN THE USA TO ISOLATE AND QUARANTINE PEOPLE FOR TWO WEEKS WHO ARE POSITIVE FOR CORONAVIRUS, MANY OF WHOM DO NOT EVEN HAVE ANY SYMPTOMS. THE NUMBER OF CASES AND DEATHS WILL ALMOST CERTAINLY INCREASE FOR THE COMING MONTH OR TWO, BUT IT IS LIKELY TO CEASE WHEN THE WARM WEATHER COMES OUT, LIKE THE FLU SEASON DOES EACH YEAR. HOPEFULLY A VACCINE WILL BE DEVELOPED BEFORE IT POTENTIALLY RETURNS IN THE FALL. SARS AND MERS ARE MUCH MORE SEVERE CORONAVIRUS PANDEMICS THAT OCCURRED IN THE PAST TWENTY YEARS AND EACH CAME AND WENT AND NO LONGER OCCUR OTHER THAT POSSIBLE RARE INCIDENTS. THEY PROBABLY ALL STARTED IN BATS FIRST, THEN OTHER BITTEN ANIMALS, THEN HUMANS. SOME RECOMMEND NO LONGER SHAKING HANDS OR THE EUROPEAN TRADITION OF KISSING ON THE CHEEK WHEN GREETING FRIENDS, AT LEAST FOR THE TIME BEING UNTIL THIS CRISIS IS PAST. IT IS IMPORTANT NOT TO PANIC AND TO GET CURRENT INFORMATION IN PERSPECTIVE.

In today’s DailyCyber Podcast I discuss the basics about the Coronavirus. What I am hearing companies are starting to do ie. restrict travel, work from home, educate their employees to not go to events with more than 10 people and much more.  "Coronaviruses (CoV) are a large family of viruses that cause illness ranging from the common cold to more severe diseases such as Middle East Respiratory Syndrome (MERS-CoV) and Severe Acute Respiratory Syndrome (SARS-CoV). A novel coronavirus (nCoV) is a new strain that has not been previously identified in humans.  Coronaviruses are zoonotic, meaning they are transmitted between animals and people.  Detailed investigations found that SARS-CoV was transmitted from civet cats to humans and MERS-CoV from dromedary camels to humans. Several known coronaviruses are circulating in animals that have not yet infected humans.Common signs of infection include respiratory symptoms, fever, cough, shortness of breath and breathing difficulties. In more severe cases, infection can cause pneumonia, severe acute respiratory syndrome, kidney failure and even death. Standard recommendations to prevent infection spread include regular hand washing, covering mouth and nose when coughing and sneezing, thoroughly cooking meat and eggs. Avoid close contact with anyone showing symptoms of respiratory illness such as coughing and sneezing.”Reference: https://www.who.int/health-topics/coronavirus "Researchers first isolated a coronavirus in 1937. They found a coronavirus responsible for an infectious bronchitis virus in birds that had the ability to devastate poultry stocks.Scientists first found evidence of human coronaviruses (HCoV) in the 1960s in the noses of people with the common cold. Two human coronaviruses are responsible for a large proportion of common colds: OC43 and 229E.The name “coronavirus” comes from the crown-like projections on their surfaces. “Corona” in Latin means “halo” or “crown.”Among humans, coronavirus infections most often occur during the winter months and early spring. People regularly become ill with a cold due to a coronavirus and may catch the same one about 4 months later.This is because coronavirus antibodies do not last for a long time. Also, the antibodies for one strain of coronavirus may be ineffective against another one.SymptomsCold- or flu-like symptoms usually set in from 2–4 days after a coronavirus infection and are typically mild. However, symptoms vary from person-to-person, and some forms of the virus can be fatal.Symptoms include:sneezingrunny nosefatiguecoughfever in rare casessore throatexacerbated asthmaScientists cannot easily cultivate human coronaviruses in the laboratory unlike the rhinovirus, which is another cause of the common cold. This makes it difficult to gauge the impact of the coronavirus on national economies and public health.There is no cure, so treatments include self-care and over-the-counter (OTC) medication. People can take several steps, including:resting and avoiding overexertiondrinking enough wateravoiding smoking and smoky areastaking acetaminophen, ibuprofen, or naproxen for pain and feverusing a clean humidifier or cool mist vaporizerA doctor can diagnose the virus responsible by taking a sample of respiratory fluids, such as mucus from the nose, or blood."Reference: https://www.medicalnewstoday.com/articles/256521#types Preventative Measures: -Wash your hands frequently -Practice Good respiratory hygiene -How to deal with stress  https://www.who.int/emergencies/diseases/novel-coronavirus-2019/advice-for-public  See all article here: https://www.who.int/health-topics/coronavirushttps://www.medicalnewstoday.com/articles/256521https://www.medicalnewstoday.com/articles/256521#typeshttps://www.who.int/emergencies/diseases/novel-coronavirus-2019https://www.who.int/health-topics/coronavirushttps://covid19info.live/

Dec 20th recording: https://anchor.fm/GGForChrist/episodes/PODMAS-DAY-20-The-fight-begins-e9mcb7 Prayer Protects Pray for loved ones by name, one by one. You can never pray too much for one person. Sometimes it helps to make a list of all the people that you need to pray for each day. Doing this not only offers us protection but also sets a great example for our children. Coronaviruses are a large family of viruses that are common in people and many different species of animals, including camels, cattle, cats, and bats. Rarely, animal coronaviruses can infect people and then spread between people such as with MERS-CoV, SARS-CoV, and now with this new virus (named SARS-CoV-2). The SARS-CoV-2 virus is a betacoronavirus, like MERS-CoV and SARS-CoV. All three of these viruses have their origins in bats. The sequences from U.S. patients are similar to the one that China initially posted, suggesting a likely single, recent emergence of this virus from an animal reservoir. Early on, many of the patients at the epicentre of the outbreak in Wuhan, Hubei Province, China had some link to large seafood and live animal market, suggesting animal-to-person spread. Later, a growing number of patients reportedly did not have exposure to animal markets, indicating person-to-person spread. Person-to-person spread was subsequently reported outside Hubei and in countries outside China, including in the United States. Some international destinations now have apparent community spread with the virus that causes COVID-19, meaning some people have been infected who are not sure how or where they became infected. Learn what is known about the spread of newly emerged coronaviruses. CONNECT WITH ME If you would like to get in touch with me, feel free to contact me at https://gloriagrossi.com/. Alternatively, you can reach me at https://www.classic9ija.online. You can also connect with me on- Twitter: https://twitter.com/prettypettilogy Pinterest: https://www.pinterest.it/laurelgobethel/ Instagram: https://www.instagram.com/adaezeboltbethel/ Facebook (Authors Only): https://www.facebook.com/kindlereviewclub Facebook (Connection Link): https://www.facebook.com/Adaezeboltbethel/ Goodreads: https://www.goodreads.com/gloriagrossi

Scary Mysteries of the Month – February 2020 Scary Mysteries of the Month is a compilation of the weird, disturbed, frightening and downright baffling stories of the month. From UFOs, serial killers, ancient sites, mysterious creatures, and even ghosts – these are your Scary Mysteries for February. 5. 3rd Kevin Spacey Accuser Dead Kevin Spacey was once considered a top actor in Hollywood. But since news of his sexual misconduct broke open, everyone in Hollywood began ditching him. Even Spacey himself went into hiding for a while. But despite people coming forward with stories of Spacey’s inappropriate sexual behavior, it seems no one will survive to make sure he’ll face the charges, as three of his accusers have coincidentally died within just one year. 4. Lori Vallow and Chad Daybell The story of Lori Vallow and Chad Daybell broke open when concerned relatives asked for a welfare check on her adopted son, Joshua “JJ” Vallow (7). Apparently, he hasn’t been seen by relatives since September 2019 and they wanted to know how he was doing, citing he has “special needs.” 3. CEO of Nissan Escapes Japan Carlos Ghosn stepped down as CEO of Nissan on April 2017, but remained as chairman of the company. The following year, on November 19, 2018, Ghosn was arrested at Haneda Airport for allegations of embezzlement and underreporting his earnings. Ghosn was arrested together with his top aide, Greg Kelly, a Nissan director and former head of Human Resources. At the same time, the Nissan Board unanimously ousted him as Nissan’s chairman. 2. Fotis Dulos It was May 24, 2019, when friends of Jennifer Farber Dulos from Connecticut reported her missing. A well-known banker and philanthropist, Jennifer was married to Fortis Dulos in 1989. After 13 years of marriage, the couple called it quits and decided to file for divorce in 2017. 1. Coronavirus After the SARS virus blew up in 2003 and the MERS-Cov or Middle East respiratory syndrome coronavirus in 2012, this new virus dubbed as the 2019-nCov or the Novel Coronavirus is slowly becoming a global pandemic.

Dec 20th recording: https://anchor.fm/GGForChrist/episodes/PODMAS-DAY-20-The-fight-begins-e9mcb7 Coronaviruses are a large family of viruses that are common in people and many different species of animals, including camels, cattle, cats, and bats. Rarely, animal coronaviruses can infect people and then spread between people such as with MERS-CoV, SARS-CoV, and now with this new virus (named SARS-CoV-2). The SARS-CoV-2 virus is a betacoronavirus, like MERS-CoV and SARS-CoV. All three of these viruses have their origins in bats. The sequences from U.S. patients are similar to the one that China initially posted, suggesting a likely single, recent emergence of this virus from an animal reservoir. Early on, many of the patients at the epicenter of the outbreak in Wuhan, Hubei Province, China had some link to large seafood and live animal market, suggesting animal-to-person spread. Later, a growing number of patients reportedly did not have exposure to animal markets, indicating person-to-person spread. Person-to-person spread was subsequently reported outside Hubei and in countries outside China, including in the United States. Some international destinations now have apparent community spread with the virus that causes COVID-19, meaning some people have been infected who are not sure how or where they became infected. Learn what is known about the spread of newly emerged coronaviruses. CONNECT WITH ME If you would like to get in touch with me, feel free to contact me at https://gloriagrossi.com/. Alternatively, you can reach me at https://www.classic9ija.online. You can also connect with me on- Twitter: https://twitter.com/prettypettilogy Pinterest: https://www.pinterest.it/laurelgobethel/ Instagram: https://www.instagram.com/adaezeboltbethel/ Facebook (Authors Only): https://www.facebook.com/kindlereviewclub Facebook (Connection Link): https://www.facebook.com/Adaezeboltbethel/ Goodreads: https://www.goodreads.com/gloriagrossi

主播丨 丁教 嘉宾丨 卢山教授 后期丨 Luke、迪卡普里鑫 上一期「疫情中的公司们」从宏基因的角度给大家解读了核酸检测盒的一些问题 (http://guiguzaozhidao.fireside.fm/s4e03)，本期节目的我们来谈谈疫苗。 当然，做「疫苗」这个话题需要勇气，因为这中间涉及到大量生物学和医学知识，但还好我们有幸请到了卢山教授作为本期嘉宾。卢教授是美国麻省州立大学医学院的终身教授，主要从事 HIV 疫苗的相关研究；同时卢教授也一直从事多种新型人类疫苗的开发和试验，是核酸疫苗（DNA vaccine）的主要发明人之一，曾在世界上首次在人体内使用DNA联合蛋白质疫苗。 本期卢教授的解释，将帮助我们理解为什么疫苗并不可能那么快就出现，以及整个商业环节和公关政策为什么其实对疫苗对研发并不那么有利。 由于是远程电话采访，本期录音效果有点不尽人意，如果觉得音质不能忍受的小伙伴，还可以搜索「声动活泼」在我们的公众号内，查看本期的完整文字版本内容。 另外，硅谷早知道第四季已经上线，需要大家在喜马拉雅、苹果 Podcasts 等各大平台上重新订阅收听。 本期主播 丁教，声动活泼联合创始人 本期嘉宾 卢山教授，美国麻省大学医学系终生教授，国际疫苗学会前任主席 The takeaway 为什么大多数急性病毒是没有特效药？病毒在体内周期短，即使药物消灭了病毒本身，可病毒制造的症状已在体内产生。所以最好的治疗是“支持治疗”； 为什么即使有的公司宣布研发成功，也并不代表已生产出有效可投入市场的疫苗？ 疫苗从研发，到临床，再到投入使用，需要多部门多步骤反复检验有效性和副作用，整个过程都需要严密考核； 为什么投资人，大公司等很多机构会不愿意在疫苗方面进行投入？像2003年 SARS 病毒爆发又消失一样，大量资金投入生产的疫苗会瞬间失去市场，而这会严重阻挠大生物制药公司生产疫苗的积极性； 新的跨界合作基金投入，也许可以解决无人还愿意研发疫苗等问题，并可以给全球急性爆发疫苗带来更快的疫苗生产反应时间。新型合作方式有可能会影响整个未来生物制药行业； 除了生物制药技术本身的发展以外，疫苗的研发还依赖政府、社会对于疫苗保护的公共态度，如果多方面积极合作，还是可以相对较快地研制出疫苗的； DNA疫苗不同于传统疫苗，提纯质粒DNA工艺简便，是亚单位疫苗技术以来的重大突破，质粒DNA还可以结合从而针对不同病毒，这使得DNA疫苗生产的灵活性大大增加。 本期讨论的主要问题 面对病毒，有特效药吗 为什么疫苗研发时间这么长 为什么针对埃博拉病毒和艾滋病毒的疫苗技术可以转而用于新型冠状病毒 为什么说和疫苗有关的好消息频出，但还远未到可以投入使用的阶段 流行病防范创新联盟（CEPI）在全球疫情中起到什么样的作用 访谈中提及名词 GMP：（GOOD MANUFACTURING PRACTICES）药品生产质量管理规范GMP是一套适用于制药、食品等行业的强制性标准，要求企业从原料、人员、设施设备、生产过程、包装运输、质量控制等方面按国家有关法规达到卫生质量要求，形成一套可操作的作业规范帮助企业改善企业卫生环境，及时发现生产过程中存在的问题，加以改善。 CEPI：（The Coalition for Epidemic Preparedness Innovations）流行病防范创新联盟；CEPI成立于2017年达沃斯论坛，旨在开发疫苗来阻止未来的流行病。 CEPI已获得挪威，德国，日本，加拿大，澳大利亚，比尔和梅琳达·盖茨基金会以及惠康的多年资助。 自2017年1月启动以来，CEPI已宣布了三个征集建议书。第一个呼吁是针对拉萨病毒，中东呼吸系统综合症冠状病毒（MERS-CoV）和尼帕病毒的候选疫苗。第二个呼吁是开发可用于针对未知病原体的快速疫苗开发的平台。第三个呼吁是针对裂谷热和基孔肯雅病毒的候选疫苗。2020年1月其 CEO 哈切特（Richard Hatchett）表示，“我们已经建立了三个合作伙伴关系，共同开发针对新型冠状病毒的疫苗。”这三家合作伙伴分别是一家美国企业Inovio Pharmaceuticals，澳大利亚的亚昆士兰大学和另一家美国生物技术公司摩登那（Moderna）。 WHO：（World Health Organization）世界卫生组织 DNA/RNA：脱氧核糖核酸/核糖核酸。本次谈话中卢教授提到的DNA/RNA，多指DNA/RNA疫苗，都属于核酸疫苗（nucleic acid vaccine）。核酸疫苗是将编码某种抗原蛋白的外源基因(DNA 或RNA ) 直接导入动物体细胞内， 并通过宿主细胞的表达系统合成抗原蛋白， 诱导宿主产生对该抗原蛋白的免疫应答， 以达到预防和治疗疾病的目的。 FDA：（Food and Drug Administration）美国食品药品管理局。 NIH：（National Institutes of Health）美国国立卫生研究所；是美国最高水平的医学与行为学研究机构，初创于1887年，任务是探索生命本质和行为学方面的基础知识。 NIAID：（National Institute of Allergy and Infectious Diseases ）美国国立过敏和传染病研究所；隶属NIH NGO：（nongovernmental organization）非政府组织。 CDC：（Centers for Disease Control）疾病预防控制中心。 Pharmaceuticals：制药公司。 Pandemic：流行病。 BGM The End Of Summer - Ave Air Eye of the Newscaster - Out To The World 微博：@声动活泼 微信公众号：@声动活泼 网站：shengfm.cn 支持/打赏我们：http://shengfm.cn/donation Special Guest: 卢山.

Son güncelleme: 07.04.2020 Koronavirus’lar (CoV), soğuk algınlığından Orta Doğu Solunum Sendromu (MERS-CoV) ve Ağır Akut Solunum Sendromu (SARS-CoV) gibi daha ciddi hastalıklara kadar çeşitli hastalıklara neden olan büyük bir virüs ailesidir. Çoğu CoV, soğuk algınlığına neden olur. Coronavirus’lar zoonotik olup, hayvanlardan bulaşarak insanlarda hastalık yapabilir. Detaylı araştırmalar sonucunda, SARS-CoV'un misk kedilerinden, MERS-CoV'un ise tek hörgüçlü develerden insanlara bulaştığı ortaya çıkmıştır. Henüz insanlara bulaşmamış olan ancak hayvanlarda saptanan birçok coronavirüs mevcuttur. ​1​ 2003'de şiddetli Akut Solunum Sendromu Coronavirüs (SARS CoV) salgını ve 2012'de Orta Doğu Solunum Sendromu Coronavirüs (MERS-CoV) salgını (ilgili yazıya buradan ulaşabilirsiniz) göz önüne alındığında, 2019-nCoV son yirmi yılda küresel halk sağlığı kurumlarını yüksek alarma geçiren üçüncü durum olduğu gözleniyor.​2​ [box type="warning" align="" class="" width=""] 07 Nisan 2020 itibari ile dünyada​​ 74 ülkede toplam doğrulanmış COVID-19 vaka sayısı 1,247,182 ve buna bağlı 69,212 saptanmış. Ülkemizde ise 30,217 vaka ve 649 ölüm görüldü.​3​ [/box] 2019-nCoV, ilk kez 29 Aralık 2019'da Wuhan'daki bir hastaneye dört kişinin pnömoni nedeniyle yatışı ile hayatımıza girdi.  Bu dört hastada da canlı kümes hayvanları, su ürünleri ve çeşitli vahşi hayvanlar satan Wuhan Deniz Ürünleri Toptan Satış Pazarında (The Huanan Southern China Seafood Wholesale Market) çalışma öyküsü mevcuttu. 2019-nCoV kaynağı henüz bilinmese de Wuhan Deniz Ürünleri Toptan Satış Pazarında satılan ürünler göz önüne alındığında vahşi hayvanlardan insanlara bulaştığı düşünülmektedir. Virüsün orijini ve insanlar arasında yayılma özelliği tam olarak bilinmese de olgu sayısının artması insan-insan bulaşı düşündürmekteydi. Sağlık çalışanlarında hastalığın ortaya çıkması insandan insana bulaş olduğunu kanıtlar niteliğindedir. Bulaşma yolu ise damlacık yoluyla olmaktadır (Yakın  temas, 1 metre riskli).​4​ Ortalama inkübasyon süresi ile ilgili sınırlı bilgi mevcuttur. Çalışmalarda ortalama inkübasyon süresi 5.2 gün bulunmuştur. MERS-CoV ve SARS-CoV epidemiyoloji bilgisine göre 14 güne kadar inkübasyon süresi olabileceği düşünülmektedir.  ​5​ Hastaların yarıdan fazlası 60 yaş üstünde ve ek hastalıkları mevcut olduğu görülüyor. Ölümlerin çoğu ise 65 yaş üzeri. Ancak Fİlipinlerde görülen 43 yaş bir hastanın ölümü ve son olarak da hastalığı ilk fark eden Dr. Li Wenliang'ın hayatını kaybetmesi ise beklenmedik bir durum oluşturuyor. [box type="info" align="aligncenter" class="" width=""] Zaman Çizelgesi 29 Aralık 2019 = Wuhan'daki bir hastaneye pnömonisi olan dört kişinin yatışı Dört hastada da canlı kümes hayvanları, su ürünleri ve çeşitli vahşi hayvanlar satan Wuhan Deniz Ürünleri Toptan Satış Pazarında çalışma öyküsü! 31 Aralık 2019 = DSÖ Çin Ülke Ofisi, Çin'in Hubei eyaletinin Wuhan şehrinde etiyolojisi bilinmeyen pnömoni vakalarını bildirdi 1 Ocak = Huanan Deniz ürünleri pazarı kapatıldı 6 Ocak = Çin CDC level 2 acil müdahale seviyesine yükseltti 7 Ocak = nCoV resmi olarak salgının sebebi ilan edildi etken daha önce insanlarda tespit edilmemiş yeni bir coronavirus (2019-nCoV) olarak tanımlandı 9 Ocak = 2019-nCoV gen sekansı yayımlandı, RT-PCR için primer oluşturuldu 10 Ocak = 2019nCoV kaynaklı ilk ölüm bildirildi 12 Ocak = Çin dışında ilk kanıtlı vaka görüldü (Tayland) 15 Ocak = Çin CDC level 1’e yükseltti (en yüksek seviye) 20 Ocak = Sağlık çalışanlarında nCoV varlığı gösterildi 24 Ocak = Sağlık Bakanlığı Bilim Kurulu Toplandı 29 Ocak = IKEA, Google, McDonalds gibi büyük şirketler Çin ofislerini geçiçi bir süre kapatma kararı aldı 30 Ocak = WHO tarafından küresel acil durum ilan edildi* 1 Şubat = Çin’deki Türk vatandaşları tahliye edildi, 14 gün süreyle takip edilmek üzere hospitalize edildi 2 Şubat = Çin dışında nCoV kaynaklı ilk ölüm Filipinlerde görüldü

Human coronaviruses (CoV) are a large family of viruses that can cause a variety of illnesses ranging from the common cold to severe diseases like Middle East respiratory syndrome (MERS-CoV) and Severe Acute respiratory syndrome (SARS-CoV). The World Health Organization says Novel Coronavirus (nCoV) is a new strain that had not been previously identified in humans until late 2019. Human coronavirus was first discovered in 1965 and accounts for many cases of the common cold.

Son güncelleme: 07.04.2020 Koronavirus’lar (CoV), soğuk algınlığından Orta Doğu Solunum Sendromu (MERS-CoV) ve Ağır Akut Solunum Sendromu (SARS-CoV) gibi daha ciddi hastalıklara kadar çeşitli hastalıklara neden olan büyük bir virüs ailesidir. Çoğu CoV, soğuk algınlığına neden olur. Coronavirus’lar zoonotik olup, hayvanlardan bulaşarak insanlarda hastalık yapabilir. Detaylı araştırmalar sonucunda, SARS-CoV’un misk kedilerinden, MERS-CoV’un ise tek hörgüçlü …

Human coronaviruses (CoV) are a large family of viruses that can cause a variety of illnesses ranging from the common cold to severe diseases like Middle East respiratory syndrome (MERS-CoV) and Severe Acute respiratory syndrome (SARS-CoV). The World Health Organization says Novel Coronavirus (nCoV) is a new strain that had not been previously identified in humans until late 2019. Human coronavirus was first discovered in 1965 and accounts for many cases of the common cold.

2019-nCoV salgını nedeniyle 490 kişi hayatını kaybetti Vaka sayısı 3 bin 219’unun durumu ciddi olmak üzere yaklaşık 24 bine yükseldi. Karantina altına alınanların sayısı ise 185 bin olarak belirtiliyor. 3 bin 400 yatak kapasitesine ulaşan geçici hastaneler oluşturuldu. Hubey eyaletine bağlı 17 kentte toplu ulaşım 22 ocakta durdurulmuştu. Peki korona virusu nedir? Birlikte öğrenelim. 2020 fare yılı 22 ocakta resmen başladı. Normalde Çin’de ve Çinli nüfusunun olduğu ülkelerde büyük bir coşkuyla kutlamalar yapılıyor bu tarihte. Fakat bu yıl değil çünkü Çin’deki 17 kent karantinaya alınmış durumda. Çinlilerin Güneş takvimine göre geçen yılın son günlerinde tespit edilen bir virüs insanlar arasında yayılmaya hızla başladır. Yeni bir coronavirüs türü olduğu için adına teknik olarak 2019-nCoV denmiş ama ilk kez Wuhan kentinde görüldüğü için Wuhan coronavirüsü de deniliyor. Wuhan da 11 milyon insanın yaşadığı biliniyor.Çin sokakları şu dönem bomboş, İnsanların sadece hastanelere ve hayati ihtiyaçlarını karşılamalarına izin veriliyor. Mevcut hastaneler yeterli olmadığı için büyük bir hızla yeni bir hastane yapılmaya başlandı. Alınan bilgilere göre 1000 yatak kapasiteli bu hastanenin 6 gün içerisinde tamamlanması bekleniyor. Wuhanda başlayan salgından 40 milyon insanın etkilendiği söyleniyor. Bir çok ulaşım seferi iptal edildi. Çünkü salgınlar sizlerde takdir edersiniz ki en hızlı bu şekilde yayılıyor. Corona kelimesi Latince’de taç anlamına geliyor. Bunlara mikroskopla bakınca görülen aura şekli ya da güneşin etrafındaki corona tabakasına benzer haleden ötürü bu isim verilmiş. İddialara göre salgının Wuhan’daki Hankou tren istasyonunun hemen yanında bulunan Huanan Pazarından yayıldığı söyleniyor. . Wuhan coronavirüsünün ilk kez burada ortaya çıktığı sanılıyor. Bu pazar başta deniz ürünleri olmak üzere çeşitli hayvanların satıldığı bir pazar yeri. Yılan, tavuskuşu, koala ; dev Çin semenderinden, bambu sıçanına kadar hemen her türlü hayvan bulunabiliyor. Virüsün burada satılan hayvanlardan; bir yarasa ya da zehirli yılandan insanlara geçtiği düşünülüyor. Virus daha yeni salgın etkisi yaratsa da aslında pek de genç sayılmaz, Çünkü Coronavirüsleri 1960’lı yıllarda keşfedildi. Aslında büyük bir virüs ailesidirler. Bugüne kadar bulunan bir çok coronavirüs çeşidinden 7 tanesinin insanlar arasında bulaşıcı olduğu tespit edilmiş. 7 adet farklı insan koronovirüsü bulunmaktadır: 1. İnsan koronavirüsü 229E (HCoV-229E) 2. İnsan koronavirüsü OC43 (HCoV-OC43) 3. SARS-CoV(Şiddetli akut solunum yolu sendromu) 4. İnsan koronavirüsü NL63 (HCoV-NL63, New Haven koronavirüsü) 5. İnsan koronavirüsü HKU1 6. MERS koronavirüsü (MERS-CoV) 7. Yeni koronavirüs (2019-nCoV)[7][8] 2002’deki SARS ve 2012’deki MERS salgınları bu virüslerden ortaya çıkmıştı. Hastalık solunum yollarından bulaşıyor. Ağzın arka tarafındaki ve boğazdaki hücrelere yerleşiyor ve diğer insanlara da buradan yayılıyor. Belirtiler baş ağrısı, ateş ve öksürük ve halsizlik şeklinde kendini gösteriyor.Corona Virüsün kuluçka süresi ise 2-14 gündür---- devamı için bölümü takip edin..

***PLEASE take a moment and rate our podcast*** In Episode #11: CoronavirUSA, Nick & Dan discuss the recent Coronavirus outbreak in China and its impact on life here in the United States. As a reminder, neither Nick nor Dan is a licensed medical professional and all of the information presented should be taken as common-sense information and not professional medical advice. If you’re wondering what happened to Episode #10, we recorded it, but decided not to publish it.  NOTES FROM THIS EPISODE: WuFlu Website https://wuflu.live/ Peak Prosperity Information https://www.peakprosperity.com/tag/coronavirus/ Basic Information about the novel Coronavirus https://www.youtube.com/watch?v=aPvpfC7NfR0   What is Coronovirus? Coronaviruses (CoV) are a large family of viruses that cause illness ranging from the common cold to more severe diseases such as Middle East Respiratory Syndrome (MERS-CoV) and Severe Acute Respiratory Syndrome (SARS-CoV). A novel coronavirus (nCoV) is a new strain that has not been previously identified in humans.  Coronaviruses are zoonotic, meaning they are transmitted between animals and people.  Detailed investigations found that SARS-CoV was transmitted from civet cats to humans and MERS-CoV from dromedary camels to humans. Several known coronaviruses are circulating in animals that have not yet infected humans.  How is it transmitted?Much is unknown about how 2019-nCoV, a new coronavirus, spreads. Current knowledge is largely based on what is known about similar coronaviruses. Most often, spread from person-to-person happens among close contacts (about 6 feet). Person-to-person spread is thought to occur mainly via respiratory droplets produced when an infected person coughs or sneezes, similar to how influenza and other respiratory pathogens spread. These droplets can land in the mouths or noses of people who are nearby or possibly be inhaled into the lungs. It’s currently unclear if a person can get 2019-nCoV by touching a surface or object that has the virus on it and then touching their own mouth, nose, or possibly their eyes.Symptoms For confirmed 2019-nCoV infections, reported illnesses have ranged from people with little to no symptoms to people being severely ill and dying. Symptoms can include: Fever, Cough, Shortness of breath. The info above came from either or both of the following websites: https://www.who.int/health-topics/coronavirus https://www.cdc.gov/coronavirus/2019-ncov/about/index.html Death Rate If you consider that each year, approximately three to five million people throughout the world contract seasonal influenza with an approximately 1% mortality rate, this causes 291,0000 to 646,000 people die from flu each year.  https://www.forbes.com/sites/stephenbrozak/2020/02/01/the-5-unknowns-of-the-wuhan-coronavirus/#19a0e17f48ac The estimated mortality rate is around 3.9% of the cases detected. https://www.msn.com/en-sg/news/world/coronavirus-reality-fake-news-and-conspiracy-theories/ss-BBZxnk2#image=6 Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany https://www.nejm.org/doi/full/10.1056/NEJMc2001468 Hospital Build info https://www.bbc.com/news/world-asia-china-51245156 Elderberry Studies https://www.ncbi.nlm.nih.gov/pubmed/15080016https://www.mdlinx.com/internal-medicine/article/3348 https://www.sciencedaily.com/releases/2019/04/190423133644.htm

Are there drugs that can treat coronaviruses? Timothy Sheahan talks about his drug discovery work on a compound that can inhibit all coronaviruses tested so far, and tells how his career path  took him to pharmaceutical antiviral research and then back to academia. Julie’s Biggest Takeaways: Even though the MERS-CoV was discovered as a human pathogen in 2012, it was likely percolating as a disease agent for a long time before that. Banked camel serum provides evidence that the virus had been circulating in camels for several decades prior. Differentiated ex vivo lung cultures allow study of virus infection in a 3D model representation for studying viral infection, including target cell types of both MERS-CoV and SARS-CoV. SARS-CoV prefers ciliated epithelial cells Ace2 MERS-CoV prefers nonciliated epithelial cells DPP4 Coronavirus disease in people takes place over a course of about 2 weeks. In mice, the disease is similar, but progression is faster, taking about 1 week.  The drug remdesivir (RDV) is a nucleoside analog that inhibits the coronavirus RNA-dependent RNA polymerase (RDRP). Remdesivir activity has not been tested against nCoV2019, but similarity to other viruses is promising. Bioinformatic approaches show that the nCoV2019 RDRP is 99% similar and 96% identical to SARS-CoV RDRP. Remdesivir works against every coronavirus tested so far, including viruses with highly divergent RDRP sequences, so remdesivir is likely to be effective again nCoV2019. Experiments must still be performed before reaching this conclusion, of course. Tim also hopes to discover the genetic determinants that will allow a chronic hepatitis C virus (HCV) infection in mice, but not standard inbred mice. He uses outbred mice meant to mimic the diversity of the human population, and strengthen the results. Understanding these determinants would inform human studies to better understand chronic HCV infection. Links for this Episode: MTM Listener Survey, only takes 3 minutes. Thanks! TWiV 584: Year of the Coronavirus Timothy Sheahan website at University of North Carolina Sheahan T.P. et al. Broad-Spectrum Antiviral GS-5734 Inhibits both Epidemic and Zoonotic Coronaviruses. Science Tranlational Medicine. 2017. Sheahan T.P. et al. Comparative Therapeutic Efficacy of Remdesivir and Combination Lopinavir, Ritonavir, and Interferon Beta against MERS-CoV. Nature Communications. 2020. Agostini M.L. et al. Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease. mBio. 2018. ASM Coronavirus Resource Page HOM Tidbit: Baltimore D. In Vitro Synthesis of Viral RNA by the Poliovirus RNA Polymerase. PNAS. 1964.  

10 điều cần biết về viêm phổi do nCov được Bộ Y tế giải thích Coronavirus 2019 là gì? Nguồn gốc của nCov? nCov lây lan như thế nào? 2019-nCoV có giống với virus MERS-CoV hoặc SARS không? Triệu chứng và biến chứng mà nCov gây ra là gì? Làm thế nào để kiểm tra một người có nhiễm nCov hay không? Bệnh nhân nghi nhiễm nCov khám ở đâu? Nhiệm vụ của cơ sở chuyên môn và đội ngũ y bác sĩ là gì? Biện pháp bảo vệ bản thân trước dịch bệnh? Đường dây nóng Bộ Y tế về viêm phổi Vũ Hán Bài viết gốc: https://www.tohaitrieu.net/10-dieu-can-biet-ve-viem-phoi-do-ncov/ --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/tohaitrieu/support

Dr Guerra of Authentic Biochemistry starts his lecture series on the current disease-causing Coronavirus from China. This first segment gives detail on the basics of molecular arrangement, replication, intracellular trafficking through the ER-Golgi and ultimate virion transmission with some medical-historical references to the more common animal Nidovirales/Coronavirales and the previous human outbreaks of related SARS and MERS CoV. Please visit https://www.facebook.com/danguerra00 and contribute to our Authentic Biochemistry Fundraiser! Also, subscribe to the Podcast! --- Support this podcast: https://anchor.fm/dr-daniel-j-guerra/support

Animals are some of our best friends, and have been at our side for millennia. But they can also cause human infections and kick of new epidemics, and all the big pandemics in the recent years, including swine flu, MERS, HIV and Ebola have had an animal origin. Music: Lost Radiance - On The Planet Far Away (ver. 1) Sources: Websites – Rabies. World Health Organisation. https://www.who.int/rabies/about/en/ Origins of the 2014 Ebola epidemic. World Health Organisation. https://www.who.int/csr/disease/ebola/one-year-report/virus-origin/en/ 2014-2016 Ebola Outbreak in West Africa. Centre for Disease Control. https://www.cdc.gov/vhf/ebola/history/2014-2016-outbreak/index.html Middle East respiratory syndrome coronavirus (MERS-CoV). World Health Organisation. https://www.who.int/emergencies/mers-cov/en/ Forget Ebola, Sars and Zika: ticks are the next global health threat. The Guardian Australia. https://www.theguardian.com/science/blog/2018/jan/25/forget-ebola-sars-and-zika-ticks-are-the-next-global-health-threat Publications – Drivers of Zoonotic Disease, from Sustaining Global Surveillance and Response to Emerging Zoonotic Diseases. National Research Council (US) Committee on Achieving Sustainable Global Capacity for Surveillance and Response to Emerging Diseases of Zoonotic Origin. https://www.ncbi.nlm.nih.gov/books/NBK215318/ Journal Articles – Wang LF & Crameri G. Emerging zoonotic viral diseases. Scientific and Technical Review of the Office International des Epizooties. 2014; 33 (2): 569 - 581 Allen, T, Murray KA, Zambrana – Torrelio, C, Morse SS, Rondinini C, Di Marco M, Breit N, Olival KJ & Daszak P. Global hotspots and correlates of emerging zoonotic diseases. Nature Communications. 2017; 8: 1124 Feldmann H & Geisbert TW. Ebola haemorrhagic fever. Lancet 2011; 377: 849 – 62 Banik GR, Khandaker G & Rashid H. Middle East Respiratory Syndrome Coronavirus ‘‘MERS-CoV’’: Current Knowledge Gaps. Paediatric Respiratory Reviews. 2015; 16: 197 – 202 Ki, M. 2015 MERS outbreak in Korea: hospital-to-hospital transmission. Epidemiology and Health. 2015; 37

Michael Fischer, M.D., MPH & TM has worked for the Texas Department of State Health Services (DSHS) for over 6 years in the Infectious Disease Control Unit (IDCU) and in October of 2017, he took-on the role of Antibiotic Stewardship Expert for the Health Care Safety Group of the Infectious Disease Control Unit at Tx-DSHS. “The biggest predictor has been leadership.” Prior to taking on this role, Michael served Texas as the epidemiologist and subject matter expert for prion disease surveillance. Additionally, Michael has also served as a medical epidemiologist, during outbreaks involving high consequence pathogens (West Africa Ebola Virus Disease (EVD) outbreak in 2014) or events with elevated public concern (travel-related Middle East respiratory syndrome (MERS-CoV)), providing consults to physicians, infection control practitioners, and healthcare facilities on appropriateness of testing, test results, prevention and control measures, and mechanisms of disease transmission. As the Antibiotic Stewardship Expert, Dr. Fischer's primary role is to promote the implementation and enhancement of antibiotic stewardship programs in Texas across all healthcare settings.

In the spring of 2012, a Saudi Arabian man developed symptoms resembling severe acute respiratory syndrome, or SARS. However, it wasn't caused by the SARS coronavirus. Instead it was identified as a new coronavirus named the Middle East Respiratory syndrome or MERS coronavirus. Globally, 2080 laboratory-confirmed cases of infection with MERS-CoV including at least 722 related deaths have been reported to WHO. Director of CIDRAP at the University of Minnesota and author of the book, Deadliest Enemy: Our War Against Killer Germs, Michael Osterholm, PhD joined me to talk about the threat of MERS on a larger scale and what can be done to prevent it.

In the spring of 2012, a Saudi Arabian man developed symptoms resembling severe acute respiratory syndrome, or SARS. However, it wasn’t caused by the SARS coronavirus. Instead it was identified as a new coronavirus named the Middle East Respiratory syndrome or MERS coronavirus. Globally, 2080 laboratory-confirmed cases of infection with MERS-CoV including at least 722 related […] The post MERS: Will it ever spread out of the Arabian peninsula such that the rest of the world should be concerned? appeared first on Outbreak News Today.

Hosts: Vincent Racaniello, Alan Dove, and Paul Duprex Guests: Ralph Baric, Felix Drexler, Marion Koopmans, and Stacey Schultz-Cherry From the EIDA2Z conference at Boston University, Vincent, Alan and Paul meet up with Ralph Baric, Felix Drexler, Marion Koopmans, Stacey Schultz-Cherry to talk about discovering, understanding, protecting, and collaborating on emerging infectious diseases.   Become a patron of TWiV! Links for this episode EIDA2Z meeting MERS-CoV infection of Alpaca (EID) Origins of HAV in small mammals (PNAS) WHO recommendations on influenza vaccine composition Collaborative Cross mice Video of this episode at YouTube This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100. Check out the graduate and postdoctoral programs at the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Deadline for applying to the graduate program is 1 December 2016. For more information about the Department, please visit http://bit.ly/micromssm Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler The TWiV gang reviews ten fascinating, compelling, and riveting virology stories from 2014.   Ten virology stories of 2014 Ebola virus outbreak (TWiV 314, 309, 308, 307, 306, 305, 304, 303, 302, 298, 297, 283) Directional uncoating of rhinovirus RNA (TWiV 267) Pandemic pathogen controversy (TWiV 287) Viral evolution (TWiV 275) Borna virus inhibition by endogenous DNA (TWiV 303) MERS-CoV in dromedary camels (TWiV special, TWiV 287) Oncolytic measles virus (TWiV 298) Amazing norovirus findings (TWiV 312 and 313) Toxin delivery to aphids (TWiV 272) The Salk Legacy (TWiV 281) Links for this episode Bat-filled tree (Science) Possible Ebola virus lab exposure (CIDRAP) Mishandling of Ebola virus sample (NY Times) Where could Ebola virus strike next? (NPR) New Legos of female scientists Photo and cookie by Kathy Spindler Letters read on TWiV 318 Weekly Science Picks Alan - Mystery photos from CERNRich - Adam E. Cohen: Bringing bioelectricity to lightKathy - Wired's top microbe stories of 2014Dickson - Mouse jokeVincent - The Science of Epidemics (Time Inc Special) Listener Pick of the Week Neva - Sir BacteriophageSagi - An unboring polio documentary Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Special guest: Ian Lipkin Ian joins Vincent, Alan, Rich, and Kathy to describe how his laboratory is searching for the origin of MERS-coronavirus. Links for this episode: MERS-CoV in bats (EID) Mystery virus (NY Times) Part of MERS-CoV found in bat (virology blog() T. perforatus Frag virus (Virol J) Even Nature got it wrong! (Nature) Bats: Important reservoirs of emerging viruses (Clin Micro Rev) Letters read on TWiV 247 Weekly Science Picks Kathy - Rainbows explained (Frazz)Alan - Challenge.govVincent - 23andmeRich - Spot the station Listener Pick of the Week Frank - Pacifier cleaning practices and risk of allergy development (Pediatrics) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Infectious disease expert Laurie Garrett is back with Neil deGrasse Tyson to answer your questions about deadly viruses and current epidemics like H7N9 influenza and MERS-CoV.

A brand new respiratory virus is circulating in the Middle East and of 80 cases, 44 people have died. MERS-CoV, as it has become known, is a coronavirus with close relatives in bats. In this podcast, experts speaking at a recent Public Health England conference talk about what we know so far and the important questions still to answer. We hear from John Watson, head of respiratory diseases at Public Health England; Brian McCloskey, director of global health at Public Health England; Monica Galiano, head of genomic sequencing at Public Health England's Virus Reference Department; and Ab Osterhaus, head of the Virology Department at the Erasmus Medical Centre in the Netherlands.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Matt Frieman Matt joins Vincent, Alan, and Rich to summarize what we know and what we do not know about the MERS coronavirus. Links for this episode: MERS-CoV update (WHO) MERS-CoV evolution (epidemic) Sick camel linked to MERS-CoV death (7Days) MERS-CoV hospital outbreak (NEJM) MERS-CoV French hospital cluster (Lancet) MERS-CoV family cluster (NEJM) Matt on MERS-CoV on the Voice of Russia Letters read on TWiV 239 Weekly Science Picks Matt - The Kid Should See ThisAlan - Cassini to photograph Earth Vincent -Cockroaches! (YouTube)Rich - Sydney Brenner (Web of Stories) Listener Pick of the Week Ebrahim - Virus Hunter by CJ Peters and Mark Olshaker Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv