Class of chemical compounds
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6 episodes with Polyphenol
4 episodes with Polyphenol
2 episodes with Polyphenol
3 episodes with Polyphenol
2 episodes with Polyphenol
3 episodes with Polyphenol
3 episodes with Polyphenol
How much can a change in diet influence symptoms of mental health disorders? Why are a diversity of plants and whole foods so important to include, and ultra processed foods so important to remove? Why are inflammation and microbe diversity in the gut so key to this question? What does this research mean for the life-style medicine movement and to world food policy?In this episode we have the exploding new field of nutritional psychiatry to get to grips with, that is the way our diet can influence and even treat mental health conditions. We're going to be discussing the historical separation of mind and body by science, which has led to scepticism that diet could influence mental health outcomes; the new understanding of the importance of diversity in our microbiome and inflammation to our mood and mental state; our main topic which is going to be the radical results of recent trials showing large changes in cognitive and mental health outcomes when diet is altered; we'll get into the foods that can bring about that change and why they work; and we're going to be getting into the reasons for the broken industrialised food environment that has contributed to the current mental health epidemic in the west.Fortunately, to understand this complex new field, our guest today is the very scientist that risked her reputation to conduct the first trials, facing considerable pushback, only to shift the consensus remarkably quickly with some top science, Felice Jacka. She is the Deakin University Distinguished Professor of Nutritional Psychiatry in Melbourne, the founder and director of the Food & Mood Centre, and of the International Society of Nutritional Psychiatry; She has been cited in over 100 institutional directives for food policy including the World Health Organization and UNICEF; and she is also the author of two books on this for the general public, the children's book “There's a Zoo in my Poo” and for adults “Brain Changer: How diet can save your mental health” which we'll be covering today. Her impact has been so high on public health that in 2021 she was awarded the Order of Australia for her services to nutritional psychiatry.What we discuss:00:00 Intro08:50 The historic separation between mental and physical health. 10:35 People with mental health die about 20 years earlier. 13:30 The connection between the immune system and mental health. 16:20 New microbiome & chronic inflammation research's influence on psychiatry. 20:00 Epigenetics, mitochondria (energy generation) & neurotransmitter influences. 21:15 Gut brain axis & oxidative stress response.33:30 The SMILES trial results and their integration into the consensus. 38:30 Using the Press to shorten the usual 20 year gap between results and policy change. 43:00 Industrialised food is the leading cause of chronic disease & biodiversity loss. 45:00 ‘We're not going to tell people what to eat': the food lobby's ‘nanny state' argument. 50:00 Soil depletion and the soil microbiome. 50:50 The life-style psychiatry movement: Diet, sleep and exercise. 01:05:30 Take out ultra-processed foods - even the nutritionally balanced ones. 01:12:30 Cognitive ability and memory reduced by processed foods. 01:14:45 Nutritional and energetic equivalent foods have totally different outcomes for the microbiome. 01:19:15 Put in a variety of plants - 30 a week. 01:20:20 The mediterranean diet. 01:24:50 Polyphenol science so far. 01:27:00 Emulsifiers and artificial sugars - the mucosal lining of the gut. 01:30:15 Fermented foods - the waste products of the bacteria are beneficial. References:Felice Jacka, “Brain Changer: The Good Mental Health Diet”Felice Jacka, “There's a Zoo in my Poo”Melissa Lane et al, ‘Ultra‐Processed Food Consumption and Mental Health: A Systematic Review and Meta‐Analysis of Observational Studies' paperFelice Jacka' et al, ‘A randomised controlled trial of dietary improvement for adults with major depression (the 'SMILES' trial)' Paper
In this powerful solo episode of Plant-Based Curious, host Diane Randall, M.A. CHC, merges raw personal storytelling with groundbreaking science to reveal how food rewires mental health. Struggling with chronic fatigue, brain fog, and a near Crohn's diagnosis in her 30s while juggling tech career chaos and single motherhood, Diane shares her transformative pivot to plant-based eating—and how it saved her mind and body. Science You'll Geek Out Over: How chronic inflammation from processed foods fuels depression/anxiety (and the 2022 study proving plants fight it). Why dopamine receptors hate cheese (and love lentils + berries) for sustained energy. Underrated Brain Heroes:Zinc (hello, pumpkin seeds!) for neurotransmitter magic. Vitamin C in bell peppers to boost serotonin. Polyphenol powerhouses like dark chocolate that cross the blood-brain barrier. Actionable Bites You Can't Skip: Diane's 50% Plate Rule for instant meal upgrades. Why swapping coffee for chamomile tea might save your afternoon. Brain Bowl Recipe: Sweet potato + tahini dressing = serotonin heaven. Why Listen? Relatable AF: Diane's burnout-to-breakthrough journey mirrors your struggles. No Fluff, Just Science: Cutting-edge studies made deliciously simple. Your Weekly Challenge: Add one antioxidant-rich food (think turmeric or berries) and share your creation with the community! Perfect for anyone battling stress, mental fog, or burnout—this episode serves equal parts hope, strategy, and “aha!” moments. Tag a friend who needs a brain boost! Follow Plant-Based Curious for more episodes on eating your way to a brighter mind and resilient body.Send us a textSupport the showReady to Dive Deeper into Plant-Based Living?If this episode sparked your curiosity, we've got even more to help you on your journey! Whether you're looking for Group Coaching to stay motivated, Workshops to sharpen your skills, or inspiring Books and Blogs to keep you informed, we've got you covered. Start with our FREE eBook – your ultimate guide to thriving on a plant-based lifestyle! Click here to explore all our resources and take the next step toward a healthier, happier more sustainable you. Let's grow together! Get Your FREE eBook & Explore More Now!
Is it better to keep the leaves during the milling process, even adding more if necessary, or should the olives enter the mill completely leaf-free? What is the correct school of thought: leaf or no leaf?
In this episode, we dive into the interplay between the gut microbiota (their postbiotics) and the immune system. We will examine how gut microbiome-derived metabolites, such as short-chain fatty acids (SCFAs) and polyphenol metabolites, influence immune function by modulating key cellular and molecular pathways within the intestinal mucosa. Additionally, we discuss strategies for supporting butyrate production and optimizing microbiome health to foster a balanced and resilient gut-immune axis. Topics: 1. Introduction Overview of the gut-immune axis. Importance of gut microbiome-derived metabolites in supporting immune function. 2. The Intestinal Barrier Layers of the intestinal wall Focus on mucosa, specifically the epithelium and lamina propria. 3. Structure of the Intestinal Layers The intestinal lumen, mucus layer, epithelium (with tight junctions), and lamina propria. Importance of the lamina propria as a hub for immune responses and structural integrity. 4. Cellular and Structural Components of the Lamina Propria Extracellular matrix (ECM): structural support. Fibroblasts and myofibroblasts. Lymphatic vessels: immune cell transport, linking mucosal and systemic immune systems. 5. Immune Cells in the Lamina Propria T cells: immune tolerance, regulatory T cells (Tregs). B cells: Secretory immunoglobulin A (sIgA). Dendritic cells: antigen sampling and presentation. Macrophages: pathogen clearance. Mast cells 6. Role of Secretory Immunoglobulin A (sIgA) Functions as a first-line defense in the intestinal mucus layer. Neutralizes pathogens, prevents epithelial adhesion. 7. Postbiotics Overview Bioactive compounds produced by gut microbiota. Examples: short-chain fatty acids (SCFAs) 8. Short-Chain Fatty Acids (SCFAs) and Their Functions Influence on Treg cells in the lamina propria, promoting immune tolerance. Butyrate also as an energy source for epithelial cells. 9. Supporting Butyrate Production Microbiome optimization to enhance beneficial butyrate-producing microbes. Use of prebiotics: resistant starch, soluble fibers, and polyphenols. Supplementation with sodium butyrate as an additional tool. 10. Other Postbiotics Antimicrobial peptides produced by beneficial microbes. Complex carbohydrates produced by beneficial microbes and can act as prebiotics. Polyphenol metabolites: Gut microbiota biotransforms polyphenols into bioactive metabolites with increased bioavailability. 11. Specific Polyphenols Examples: resveratrol, quercetin, and ellagitannins. Effects on intestinal barrier function, inflammation, and immune cell populations. "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support
Welcome back to our weekend Cabral HouseCall shows! This is where we answer our community's wellness, weight loss, and anti-aging questions to help people get back on track! Check out today's questions: Darren: Good day to you, your family and team Dr Cabral. I listened to Dr Rhonda Patrick saying Bananas, Beets, Swiss chard, collard greens have an enzyme in them called polyphenol oxidase which degrades Polyphenols in blueberries and other high polyphenol containing foods. She says it's best not to add them to smoothies with blueberries etc. Is this accurate or the drawback is not that bad? Jenn: Hi Dr. Cabral! Ever since I was pregnant with my second baby, I get this metal taste in my mouth. It happened during the first trimester, was happening as much during the 2nd but came back in the 3rd. From what I've researched it based on hormonal changes. But 7 months postpartum I'm still experiencing the metal taste every day - typically at night. I thought this goes away after giving birth. I'm so curious as to why this continues to happen and what I can do about it. Thank you so much!! Vanessa: I have had recurring yeast infections for a year. I have taken a gut test where I collected stool for three days then did the micribiome labs gut support package for six months and cut out most sugar (only in coffee) and went mostly keto/carnivore. Last antibiotic taken three years ago after a surgery. It went well for about four months. Now it's back in my vagina and I get it on two fingers. I have a lot of stress due to a divorce and job (nurse). Please help with a protocol to rid this yeast once and all from my body. Thank you for your time Carol: Hi dr. Cabral. I have something called Hoffa's syndrome in my knees. I was wondering if you had a natural approach to this, my insurance will cover steroid shots, but do not want to go that route. Or liposuction. Thanks for any advice. I appreciate all you do. Teresa: Hi Dr Cabral, can you please talk about hashitoxicosis. I have Hashimotos and my latest thyroid tests showed that my TPOab was really high and my other thyroid levels were hyperactive. Thank you for tuning into today's Cabral HouseCall and be sure to check back tomorrow where we answer more of our community's questions! - - - Show Notes and Resources: StephenCabral.com/3207 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!
"This video delves into the fascinating world of cranberry juice and its potential benefits for skin health. A recent randomized controlled trial explored the effects of a polyphenol-rich cranberry beverage on various aspects of skin health in women. The results revealed that regular consumption of this cranberry drink positively impacted skin lipids, skin microbiome, inflammation, and oxidative stress. Discover how this natural beverage could contribute to healthier, more radiant skin." #cranberry #cranberryjuice #wrinkles #skinhealth #antiaging Christman L, De Benedetto A, Johnson E, Khoo C, Gu L. Polyphenol-Rich Cranberry Beverage Positively Affected Skin Health, Skin Lipids, Skin Microbiome, Inflammation, and Oxidative Stress in Women in a Randomized Controlled Trial. Nutrients. 2024; 16(18):3126. https://doi.org/10.3390/nu16183126 skin, cranberry, juice, aging, wrinkles, antioxidants, collagen, elastin, elasticity, firmness, texture, fine lines, wrinkles, sagging, premature aging, photoaging, sun damage, UV rays, free radicals, oxidative stress, inflammation, microbiome, skin barrier, hydration, moisture, youthful, radiant, glowing, natural, beverage, nutrition, dermatology, clinical, research --- Support this podcast: https://podcasters.spotify.com/pod/show/ralph-turchiano/support
How can you mediate the phytonutrient-destroying enzyme in avocados, bananas, and mushrooms?
An enzyme in bananas can destroy some of the phytonutrients in berries and cocoa, but there is a way to reduce the effect.
Olivenöl ist ein wahrer Gesundheitsschatz! Das "grüne Gold" ist nicht nur ein wesentlicher Bestandteil der griechischen Kultur und Lebensart, sondern auch ein unverzichtbares Element in der mediterranen Küche - und das bereits seit der Antike. Wir gehen in dieser Podcast-Episode auf die unglaubliche Reise des Olivenöls: Wie erkennt man die beste Qualität? Was ist der Polyphenolgehalt? Warum spielt der Säuregehalt eine so große Rolle? Und was verrät die Herkunft des Öls über seinen Geschmack? Extra natives Olivenöl gilt als die "Königin der Olivenöle" – und das zu Recht! Es hat die höchste Qualität und verleiht Euren Gerichten einen unvergleichlichen Geschmack. Wir tauchen ein in die Geheimnisse dieses besonderen Öls - denn auch hier gibt es feine Unterschiede. Trotz all seiner gesundheitlichen Vorzüge bleibt Olivenöl ein Genussmittel, den man besser in Maßen genießen sollte. Aber eines ist sicher: Kein anderes Öl bietet eine derart große Vielfalt an Aromen und gesundheitsfördernden Eigenschaften wie Olivenöl. Alles Liebe, Eure Anastasia. -- Ein ALL EARS ON YOU Original Podcast.
Welches Öl eignet sich am Besten zum Erhitzen? Ist es Sonnenblumen- oder Rapsöl? Was bedeutet eigentlich raffiniert und nativ und wieso ist Olivenöl schädlich wenn es erhitzt wird? Ist es das überhaupt? Wir finden es raus! Mein Tipp: MANI natives Olivenöl extra, Polyphenol, bio, 0,375 l Flasche (00:00) Intro (01:45) Fettsäuren: gesättigt vs. ungesättigt (07:45) Raffinierte Öle (10:55) Welches Öl zum braten - Meine Empfehlung (20:53) Fazit & Outro
Listener question: “Is flaxseed good or bad for endo? There is so much mixed info out there about it around increasing / decreasing eostrogen. Is there a better type of flaxseed - oil, roasted seeds, ground seeds, tablets high in flax?” Okay, I'm glad you asked this question because it comes up a lot and it's not a straightforward answer. Flax is a type of phytoestrogen. A phytoestrogen is a type of plant compound which chemically is similar to oestrogen but isn't a form of oestrogen and due to the similar structures, phytoestrogens can bind to oestrogen receptors in the body. When people hear this, they worry and think that means that it'll increase oestrogen levels, when typically, the opposite is true. Phytoestrogens do not have the same strength as oestrogen, their oestrogenic effects are much weaker than oestrogen, so in theory, by binding to an oestrogen receptor, they are blocking real oestrogen levels, which is great if you're someone who struggles with oestrogen dominance or high oestrogen levels. Read more. Show Notes: Flax: https://pubmed.ncbi.nlm.nih.gov/8077314/ https://pubmed.ncbi.nlm.nih.gov/32047868/ https://pubmed.ncbi.nlm.nih.gov/15702593/ https://www.sciencedirect.com/science/article/abs/pii/S1570023202002817?via%3Dihub https://www.researchgate.net/figure/Polyphenol-and-antioxidant-content-in-the-100-richest-foods-mg-per-100-g-or-mg-per-100_tbl1_47661728 Seed cycling: PCOS study https://helloclue.com/articles/culture/seed-cycling-i-tried-it-and-dug-into-the-research-on-whether-it-works Nicole Jardim's seed cycling guide Need more help or want to learn how to work with me? Free resources: This podcast! Endometriosis Net Column Endometriosis News Column Newsletter Instagram Ways to work with me: This EndoLife, It Starts with Breakfast digital cookbook Masterclasses in endo nutrition, surgery prep and recoPCvery and pain relief Live and Thrive with Endo: The Foundations DIY course One to one coaching info and application Can you help me save Jelly the kitten? We are currently travelling, working remotely, and within 24 hours of arriving in Montenegro, we met Jelly. He was extremely thin, with a distended stomach and a little lollypop head and bulging eyes. We took him to the vets where he was put on an IV drip for dehydration, and treated with antibiotics and anti-inflammatories for a bacterial infection that has spread into his bloodstream from his intestines. His intestines are damaged due to excessive worms, which has caused him to become malnourished. The vets have given us a very stark picture of the reality. If Jelly goes back on the streets, his condition will deteriorate and he will suffer until he eventually passes away. We have been told to find him a home where he can continue getting care or put him to sleep. We have found him a foster home and a forever home in the UK, but the total cost is over £1200. We have already spent hundreds on vet visits getting him to this point, and need your help, if you can. If you are able to and want to support, you can donate and read Jelly's full story on our Go Fund Me page. I truly cannot express how much your support means to me, thank you from the bottom of my heart. This episode is sponsored by Semaine. Semaine is a plant-based supplement for reducing period pain and inflammation, that you take for 7 days of your cycle, during your period. Semaine is made up of 9 super-powered plant extracts and minerals that are all vegan and sourced for maximum quality and bioavailability and selected based on the latest clinical research. If you want to try Semaine, they are currently offering 20% off your first order with code: THEENDOBELLYCOACH and they deliver worldwide! Head to: www.semainehealth.com This episode is sponsored by BeYou Cramp Relief Patches. Soothe period cramps the natural way with these 100% natural and discreet menthol and eucalyptus oil stick on patches. Click here to find out more and to shop: https://beyouonline.co.uk/pages/how-it-works
Join Dr. Moss and Ben as they delve into the unexpected benefits of coffee in the battle against cancer. Learn about Dr. Moss' unique blend, a carefully crafted recipe that enriches your daily cup with polyphenols, cafestol, kahweol, cocoa, chicory, and Ceylon cinnamon. Discover the science that shows how this potent combination serves as a prebiotic, aids metabolism, and how it may help in your fight against cancer. Tune in as we unveil the health-boosting secrets hiding in your coffee cup and learn how to transform it into an anti-cancer superfood powerhouse! Program Notes: For more information on cancer-fighting foods and supplements, please visit our website: https://www.themossreport.com 5 Defenders Mushroom Blend https://shop.realmushrooms.com/products/organic-mushroom-blend-capsules?ref=391 “A comprehensive self-help plan for cancer includes medicinal mushrooms. They are indispensable”. – Ralph W. Moss, PhD For Dr. Moss' recommended products list, please visit https://www.themossreport.com/recommended-products/ Anthony's Organic Ceylon Cinnamon Powder Anthony's Organic Roasted Chicory Root Granules Anthony's Organic Cocoa Powder Rainforest Blend Ground Coffee Articles Coffee Drinking and Risk of Lung Cancer—A Meta-Analysis https://aacrjournals.org/cebp/article/25/6/951/282888/Coffee- Drinking-and-Risk-of-Lung-Cancer-A-Meta Coffee Consumption and Lung Cancer Risk: A Prospective Cohort Study in Khon Kaen Thailand https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7771955/ A Decade of Research on Coffee as an Anticarcinogenic Beverage https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460369/ Coffee and cancer risk: A meta-analysis of prospective observational studies https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036059/ Associations of coffee and tea consumption with lung cancer risk https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460087/
Shownotes available @ https://zecohealth.com/sippingstreams/ Click below & use code zecohealth for 30% discounts off EAAs from The AminoCo https://aminoco.com/zecohealth
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.26.538474v1?rss=1 Authors: Tambe, M. A., Jacquet, A. d. R., Strathearn, K. E., Yousef, G. G., Grace, M. H., Ferruzzi, M. G., Wu, Q., Simon, J. E., Lila, M. A., Rochet, J.-C. Abstract: Parkinson's disease (PD) is a neurodegenerative disorder involving motor symptoms caused by a loss of dopaminergic neurons in the substantia nigra region of the brain. Epidemiological evidence suggests that anthocyanin (ANC) intake is associated with a low risk of PD. Previously, we reported that extracts enriched with ANC and proanthocyanidins (PAC) suppressed dopaminergic neuron death elicited by the PD-related toxin rotenone in a primary midbrain culture model. Here, we characterized botanical extracts enriched with a mixed profile of polyphenols, as well as a set of purified polyphenolic standards, in terms of their ability to mitigate dopaminergic cell death in midbrain cultures exposed to another PD-related toxicant, paraquat (PQ), and we examined underlying neuroprotective mechanisms. Extracts prepared from blueberries, black currants, grape seeds, grape skin, mulberries, and plums, as well as several ANC, were found to rescue dopaminergic neuron loss in PQ-treated cultures. Comparison of a subset of ANC-rich extracts for the ability to mitigate neurotoxicity elicited by PQ versus rotenone revealed that a hibiscus or plum extract was only neuroprotective in cultures exposed to rotenone or PQ, respectively. Several extracts or compounds with the ability to protect against PQ neurotoxicity increased the activity of the antioxidant transcription factor Nrf2 in cultured astrocytes, and PQ-induced dopaminergic cell death was attenuated in Nrf2-expressing midbrain cultures. In other studies, we found that extracts prepared from hibiscus, grape skin, or purple basil (but not plums) rescued defects in O2 consumption in neuronal cells treated with rotenone. Collectively, these findings suggest that extracts enriched with certain combinations of ANC, PAC, stilbenes, and other polyphenols could potentially slow neurodegeneration in the brains of individuals exposed to PQ or rotenone by activating cellular antioxidant mechanisms and/or alleviating mitochondrial dysfunction. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.30.534961v1?rss=1 Authors: Yang, E.-J., Frolinger, T., Westfall, S., Iqbal, U. H., Murrough, J., Pasinetti, g. M. Abstract: Scope: The goal of this study is to investigate the effects of a bioactive dietary polyphenol preparation (BDPP), which is made up of grape-derived polyphenols, on microglial responses, as well as the underlying molecular mechanisms in depression and anxiety-like behaviors. Methods and results: We find that treatment with BDPP significantly decreased depression-like and anxiety-like behaviors induced by chronic stress in mice, while leaving their locomotor activity unaffected. We also find that BDPP treatment reversed microglia activation in the amygdala and hippocampal formation, regions of the brain involved in emotional regulation, from an amoeboid shape to ramified shape. Additionally, BDPP treatment modulates the release of pro-inflammatory cytokines such as interleukin-6 via high mobility box 1 protein and the receptor for advanced glycation end products (HMGB1-RAGE) signaling pathway in activated microglia induced by chronic stress. Conclusion: Our findings suggest regional heterogeneity in microglial responses following chronic stress in subregions of the corticolimbic circuit. Specifically, activation of the immune-inflammatory HMGB1-RAGE pathway might provide a new avenue for therapeutic intervention in stress-induced anxiety- and depression-like behavior, using bioactive and bioavailable polyphenols. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Videos: Naomi Wolf discusses Post Vaxx Death Autopsies 6 (start @ 0:08) Brazil: Get a COVID vaccine or ELSE we'll take your government assistance | Redacted News (1:20) · Glycemic index and insulin index after a standard carbohydrate meal consumed with live kombucha · Polyphenols may be missing component in regulating inflammatory immune responses · Plant extract fights brain tumor · Any kind of regular exercise at any age helps the brain fight off dementia later in life · Polyphenol-rich tomato extract supports cardiovascular health through modulation of gut microbiome · Vaping can cause even more DNA damage than smoking regular cigarettes, study reveals
We start our second show of the season by revisiting one of the most memorable interviews from last season with Ilan Sobel, CEO of BioHarvest Sciences (CSE:BHSC). On last year's interview we learned about the driving mission of his company to build "human utility value". We use that as a jumping-off point as we re-unite after a notable year for the company despite global and economic headwinds.Ilan provides an update on BioHarvest's two key product verticals in the Polyphenol and Cannabis sectors, and how each are taking unique (and in some cases, similar) paths to market. Ilan also reflects on some of the choices the company has made with respect to developing its sales funnel and shares valuable lessons about acting as a "learning" organization and listening to your customers.Mr. Sobel is Chief Executive officer of BioHarvest Sciences Inc. (CSE:BHSC) - the developer and exclusive owner of the proprietary and patent-protected BioFarming technology. It is the first and only industrial-scale plant cell technology capable of producing the active plant ingredients without the necessity to grow the plant itself. The Company's technology is non-GMO and has already been validated by VINIA®, the red grapes cells functional food/dietary supplement produced and sold by BioHarvest Sciences Inc. The Company plans to generate significant revenue within the global nutraceutical ingredients and dietary supplements market with VINIA® and other Super Fruit Nutraceutical products. Further, by adapting this technology to the Cannabis plant, and building adequate production capacity, BioHarvest Sciences Inc.'s objective is to become a leading supplier of Cannabis for both medicinal and legal recreational purposes. Visit: www.bioharvest.com Host: James BlackProducer: James BlackGuest: Ilan Sobel
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.12.523723v1?rss=1 Authors: Montero-Atalaya, M., Munoz-Arnaiz, R., Makarova, J., Bartolome, B., Moreno-Arribas, V., Herreras, O. Abstract: Dietary polyphenols and in particular bioavailable metabolites resulting from gut microbiota transformations appear to have beneficial effects in situations of impaired cognition, combatting memory deficits in acute pathological models of neurodegeneration. Modifications to blood flow may underlie the effects of these molecules and although some such metabolites cross the blood-brain barrier, their targets and electrophysiological effects remain unknown. Hence, we explored the systemic and direct effects of protochatechuic acid (PCA) on electrical activity in the hippocampus and cortex of anesthetized female rats, recording evoked and spontaneous high-density field potentials (FPs) to mathematically derive pathway-specific FP generators. We found transient and sustained effects of PCA on evoked activity in the CA1 field, including paradoxical actions on excitatory transmission that depend on the route of administration. Systemic delivery of PCA altered the ongoing activity of some FP generators, albeit with marked inter-animal variation. Interestingly, PCA induced the detachment of infraslow cortico-hippocampal activities over a scale of minutes. These results point to direct actions of polyphenols on cell and network electrical activity, some of which reflect non-specific actions. Thus, dietary-derived polyphenols appear to fulfill neuromodulatory roles, encouraging the search for additional targets to better guide their use in preventing brain pathologies. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Evolving with Nita Jain: Health | Science | Self-Improvement
In a world where simplicity is attractive, Avisha NessAiver, founder of Distilled Science, bucks trends while setting out to improve his health, income, & productivity by 10x. We talk about technology in our daily work lives, the importance of having a digital second brain, and the need for adequate nutrition as we age.Chapter Summaries:[00:00:00] - Avisha NessAiver is the founder of Distilled Science, a blog dedicated to science-backed optimization and performance. He is a founder, speaker, futurist, and engineer.[00:00:41] - Avisha has recently started a series where he aims to 10x his health, productivity, and income. His approach is more ambitious than practical and believes it's better to have slightly unattainable goals and fall slightly short than to have something that's consistently attainable.[00:01:53] - The 80/20 rule states that you should aim to fail at least 20% of the time for maximal learning and improvement. The best learning speed is if you understand a good percentage of a task and then fill in the gaps with practice.[00:05:40] - In the last two years, Avisha's listened to over 25 million words using the Speechify app, and he's the number one user of the app. He regularly e-mails the company about bugs in the app and they try to fix them.[00:08:43] - Notion is a notetaking app on steroids combined with a content management system that allows you to create interlinked databases. Avisha's website is built in Notion, and he plans to give people access to his digital brain as a constantly growing resource.[00:11:37] - In the information age, it's important to have a digital second brain. Avisha recommends Building a Second Brain by Tiago Forte to help people get started with setting up their own digital back brains.[00:14:39] - The education system still needs to realize that our brains are made for critical thinking, not storing facts.[00:18:57] - Fitness trackers are overused and underused. The best use of a fitness tracker is for personal tracking and motivation, not to provide ground truth values. The relative accuracy is typically a lot more reliable than the absolute accuracy.[00:21:28] - Science media outlets sometimes report relative risk reduction instead of absolute risk reduction. The dose makes the poison, and animal studies often use extremely high doses to evaluate effects of environmental toxicants.[00:24:53] - Hormesis posits that small amounts of stressors can be beneficial to the body. However, certain enzymatic pathways in your body have a finite ability to break down compounds like caffeine and cocaine. Cumulative effects matter, and stress in general can lead to excessive cortisol production.[00:30:58] - Minor to moderate alcohol consumption is associated with increased lifespan compared to complete abstinence or heavy drinking, but it's clear that any amount of alcohol is toxic to the system. Drinking facilitates social bonding, which may be accounting for the increase in lifespan.[00:36:39] - Polyphenol-rich red wine, sometimes purported to contribute to gut health, may have more adverse effects than beneficial ones.[00:39:38] - Avisha and Nita have Ehlers-Danlos Syndrome, a condition characterized by problems with the collagen production system in the body, leaving connective tissue weaker and more prone to injury. Avisha's workout protocol is to use a lot of volume at lower percentages of the one rep maximum and slowly build up towards overall muscular increases. Working out is important for people as they get older to prevent sarcopenia.[00:44:40] - As we get older, our need for protein increases due to the loss of muscle mass. Most people lose around 1% muscle mass per year after the age of 50. Gaining more muscle during your 20s and 30s will help offset this loss. 1 gram of protein per pound of body weight is a good guideline for putting on muscle mass, but it's not enough for most people.[00:46:52] - There are many reasons why protein and muscle are essential for maintaining optimal health as we age. When you have more muscle, you are better able to move your body and maintain an active lifestyle. If your muscle starts degrading, your overall lifestyle becomes more sedentary.[00:48:53] - In his science communication strategy, Avisha tries to let the sources provide the authority and translate them in a way that is accessible to someone without a scientific background. In order to film a 60-second Tik Tok video, he spends hours reading through research papers. He plans to create more long-form content and believes personalized, targeted interventions are the future of medicine.[00:56:29] - The government is the single largest payer that will benefit from a preventative approach. The change will likely happen through the payers that are more agile and backed by things like insurance companies and large employers who will be incentivized to have a healthier employee base.[00:58:55] - There needs to be a shift in medical education towards preventative approaches rather than exclusively operating under a “diagnose then drug” paradigm. Western medicine system is very good at treating acute problems, but chronic conditions like fibromyalgia can have multiple root causes. Functional medicine doctors are known for looking at holistic approaches.[01:02:28] - Avisha tries to find a middle ground between the traditional and alternative medicine camps and believes there needs to be greater oversight in the functional wellness space. In its current form, FMT lacks standardization. Some microbes might be beneficial in one body and not in another.Connect with Avisha on TikTok & Instagram! If you enjoyed this episode, you can support the show. Thanks for listening! This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit nitajain.substack.com
video: https://app.air.inc/a/cW1vAB3wp?ts=0 The Dark Truth of America's Federation Of State Medical Boards (start @ 3:44) Black gold? Rhizome extract said to have anti-ageing and anti-diabetic effects Oryza Chemical (Thailand), Black ginger extract could have important implications for healthy ageing and diabetes, as well as athletic performance. Presented in Bangkok by Oryza Oil & Fat Chemical's Masami Kawaziri, the herbaceous plant is also called black turmeric in Japan, and krachai dum in its country of origin, Thailand. The plant's extract has been used in Thailand for many years as a traditional medicine to boost energy and relieve gastrointestinal problems, and more recently, researchers in Asia have been looking into its benefits for seniors, diabetics and sportspersons. Energising results Its polymethoxyflavones are said to enhance energy production, thereby improving glucose, fat and lipid metabolism. This can either prevent metabolic syndrome, or aid in treating diabetes. The boost in energy production also helps to enhance athletic performance and recovery. Kawaziri shared the results of a 2016 study on the effects of black ginger extract intake on physical strength, skin condition, post-exercise fatigue, and general fatigue. Subjects who had been given the extract reported an increase in strength, and being less fatigued overall and after exercise. Brains and brawn Kawaziri said this was important for the elderly as well, since the extract is believed to minimise muscle loss. He added that the extract could play a part in “preventing poor blood circulation” and lowering blood pressure. Furthermore, he said the extract could help to enhance and maintain cognitive function, delaying or perhaps even preventing diseases like Alzheimer's. Higher levels of fluoride in pregnant woman linked to lower intelligence in their children University of Toronto Fluoride in the urine of pregnant women shows a correlation with lower measures of intelligence in their children, according to University of Toronto researchers who conducted the first study of its kind and size to examine fluoride exposure and multiple states of neurodevelopment. “Our study shows that the growing fetal nervous system may be adversely affected by higher levels of fluoride exposure,” said Dr. Howard Hu, the study's principal investigator and professor of environmental health, epidemiology and global health at the Dalla Lana School of Public Health. “It also suggests that the prenatal nervous system may be more sensitive to fluoride compared to that of school-aged children.” Tap water and dental products have been fluoridated in communities in Canada and the United States (as well as milk and table salt in some other countries) by varying amounts for more than 60 years to prevent cavities and improve bone health. In recent years, fierce debate over the safety of water fluoridation – particularly for children's developing brains – has fuelled researchers to explore the issue and provide evidence to inform national drinking water standards. There are some known side effects of fluoride. For example, dental defects like mild staining are common among those ingesting recommended levels of fluoride in the United States and Canada. Skeletal fluorosis – excessive accumulation of fluoride in the bones – is much less common and only observed at levels of fluoride in the water that are more than five to 10 times higher than those recommended. “Relatively little is known, with confidence, about fluoride's impact on neurodevelopment,” said Hu, whose research team included experts from U of T, National Institute of Public Health of Mexico, University of Michigan, McGill University, Indiana University, Mount Sinai School of Medicine and Harvard School of Public Health. The study, “Prenatal Fluoride Exposure and Cognitive Outcomes in Children at 4 and 6-12 Years of Age in Mexico,” published today in Environmental Health Perspectives, analyzed data from 287 mother-child pairs in Mexico City that were part of the Early Life Exposures in Mexico to Environmental Toxicants (ELEMENT) project, which recruited pregnant women from 1994 to 2005 and has continued to follow the women and their children ever since. The research team analyzed urine samples that had been taken from mothers during pregnancy and from their children between six and 12 years of age to reconstruct personal measures of fluoride exposure for both mother and child. “This is significant because previous studies estimated exposures based on neighbourhood measurements of drinking water fluoride levels, which are indirect and much less precise measures of exposure. They also looked at children's exposures instead of prenatal exposures or had much smaller sample sizes of subjects to study,” said Dr. Hu. The researchers then analyzed how levels of fluoride in urine related to the children's verbal, perceptual-performance, quantitative, memory, and motor abilities at age four and once more between the ages of six and 12. Analyses were adjusted for other factors known to impact neurodevelopment, such as gestational age at birth, birthweight, birth order, sex, maternal marital status, smoking history, age at delivery, IQ, education, socioeconomic status and lead exposure. With regard to the study's implications for populations in North America, researchers found that urinary fluoride levels in pregnant women were somewhat higher than, but within the general range of, urinary fluoride levels seen in non-pregnant general populations in Canada and the United States. However, in Dr. Hu's opinion, the findings do not provide enough information to suggest there is no safe level of fluoride exposure. “The potential risks associated with fluoride should be further studied, particularly among vulnerable populations such as pregnant women and children, and more research on fluoride's impact on the developing brain is clearly needed.” Polyphenol blend may boost post-exercise recovery: RCT University of Murcia (Spain), and the University of Montpellier (France) Daily supplementation with a blend of extracts from mangosteen, elderberry, and pomegranate may delay muscle soreness and help manage post-exercise recovery, says a new study. Consumption of Fytexia's polyphenol-rich ingredient branded TensLess was associated with a 28% reduction in the perception of delayed onset muscle soreness (DOMS), compared with a placebo group, according to results of a randomized, placebo-controlled, crossover study. Biomarkers of muscle damage were also reduced, in correlation with the decreases in DOMS, reported scientists from Fytexia (France), Catholic University of Murcia (Spain), and the University of Montpellier (France) in the journal Phytotherapy Research . “This prospective study highlights the beneficial, both acute and sub-chronic effects of the supplementation with TensLess, a polyphenol-rich extract-based food supplement, on adverse symptoms associated with DOMS, namely eccentric exercise-related markers of muscle impairment,” they wrote. Study details The researchers recruited 13 recreationally active athletes (men and women) to participate in their study. Participants were randomly assigned to consume placebo or 1.5 grams per day of TensLess, composed of polyphenol-rich extracts from mangosteen (Garcinia mangostana L.), pomegranate (Punica granatum L.), and black elderberry (Sambucus nigra L.) combination for five days. All of the study participants performed an eccentric exercise protocol on day one of the study, and DOMS and biomarkers of muscle damage were monitored for four more days. This was then followed by a three-week “washout” period before they were crossed over to the other group for five more days. The results showed that TensLess supplementation provided a significant 33% decrease in DOMS perception as early as the first 24 hours following physical exercise, compared to placebo. In addition to this acute benefit, a 28% reduction in DOMS perception was reported compared to the placebo group for the full duration of the study. These effects were correlated with a lower levels of muscle damage-associated biomarkers, specifically creatine kinase, creatinine and myoglobin during the 4 days post-workout, added the researchers. Taken together, these positive results clearly indicate that post-exercise supplementation with TensLess may preserve myocytes and reduce soreness following eccentric exercise-induced damages, and, accordingly, significantly shorten muscle recovery. Study supports efficacy of hyaluronan for wrinkle reduction Toho University Ohashi Medical Center (Japan) Twelve weeks of supplementation with hyaluronan – also known as hyaluronic acid – may improve the “luster” of the skin and reduce wrinkles, says a new study from Japan. Data from a randomized, double-blind, placebo-controlled trial with 60 adults indicated that 120 milligrams per day of Kewpie's hyaluronan ingredients Hyabest (A) and Hyabest (S) LF-P also led to improvements in skin suppleness. “This study showed that the oral ingestion of the [molecular weight] 2 k or 300 k [hyaluronic acid] for 12 weeks suppresses wrinkles and improves the skin's luster and suppleness in people aged 59 years or less who were healthy Japanese men and women over 22 years old. From the above, [hyaluronic acid] consumption is expected to be used as a method to maintain healthy skin,” wrote researchers from Kewpie Corporation and the Toho University Ohashi Medical Center in Clinical, Cosmetic and Investigational Dermatology . Kewpie Corp funded the study. HA and skin The skin contains about 50% of the body's hyaluronan (HA), a component present in every connective tissue. Degradation of HA and collagen is reported to be a cause of wrinkles, with many ingredient suppliers exploring the potential of supplementation to improve skin health from within. Scientists from Kewpie authored a review i published in the Nutrition Journal, which concluded: “The reduction of HA in the skin by intrinsic and extrinsic factors such as aging and ultraviolet radiation, smoking and air pollutants induce dryness in the skin. However, daily HA supplements can moisturize the skin because the metabolites of HA increases the skin moisture content by having an effect on the skin cells. Thus, consuming HA affects skin cell and improves dry skin physiologically. “This review shows that consuming HA moisturizes the skin and employing HA as a dietary supplement makes the skin healthy. We believe that countries worldwide will benefit from this review and consume HA to alleviate dry skin.” The new double-blinded, placebo-controlled study adds to this body of evidence and investigated the effects of the ingredient on wrinkles. The researchers recruited 60 Japanese men and women aged between 22 and 59 to participate in their study. The participants were randomly assigned to one of three groups: Placebo, or a HA formulation using one of two varieties, with a molecular weight of 2k or 300k (Hyabest (A) and Hyabest (S) LF-P, respectively). Both groups received a dosage of 120 mg per day. Three-dimensional analysis of their skin indicated that the HA groups showed a better level of the whole sulcus (grooves in the skin) to volume ratio, wrinkle area ratio, and wrinkle volume ratio, compared to placebo and baseline values. However, only the 300 k (Hyabest (S) LF-P) group showed significantly diminished wrinkles compared with the placebo group. Exercise can make cells healthier, promoting longer life, study finds University of Virginia Whether it's running, walking, cycling, swimming or rowing, it's been well-known since ancient times that doing some form of aerobic exercise is essential to good health and well-being. You can lose weight, sleep better, fight stress and high blood pressure, improve your mood, plus strengthen bones and muscles. “Whether muscle is healthy or not really determines whether the entire body is healthy or not,” said Zhen Yan of the University of Virginia School of Medicine. “And exercise capacity, mainly determined by muscle size and function, is the best predictor of mortality in the general population.” Yan and colleagues have completed a study in mice that, for the first time, shows that just one bout of moderate-to-intense exercise acts as a “stress test” on mitochondria in muscles. They discovered that this “stress test” induced by aerobic exercise triggers a process called mitophagy, where the muscle disposes of the damaged or dysfunctional mitochondria, making the muscle healthier. Yan compares exercise-induced mitophagy to a state vehicle inspection that removes damaged cars from the streets. “Aerobic exercise removes damaged mitochondria in skeletal muscle,” Yan said. “If you do it repeatedly, you keep removing the damaged ones. You have a better muscle with better mitochondrial quality. We clean up the clunkers, now the city, the cell, is full of healthy, functional cars.” How Exercise Removes Mitochondria ‘Clunkers' For this study, Yan and colleagues assessed the skeletal muscle of a mouse model where they had added a mitochondrial reporter gene called “pMitoTimer.” The mitochondria fluoresce green when they are healthy and turn red when damaged and broken down by the cell's waste-disposal system, the lysosomes. The mice ran on a small treadmill for 90 minutes and Yan's team observed mitochondrial stress (signs of “state inspection”) and some mitophagy (towing of the clunkers) at six hours after exercise. Yan explained that exercise in these mice also stimulated a kinase called AMPK, which in turn switched on another kinase, Ulk1. These chemical reactions appear to be important in control of the removal of dysfunctional mitochondria. “When its turned on, Ulk1 activates other components in the cell to execute the removal of dysfunctional mitochondria,” Yan said. “It's analogous to a 911 call where a tow truck removes the clunkers. However, we still do not know how these activities are coordinated.” LED lights safer, more effective in producing Vitamin D3 than sunlight Boston University Research published in Scientific Reports showsthat light from RayVio's 293nm ultraviolet (UV) LED is more efficient than sunlight at producing vitamin D3 in skin samples. Tyler Kalajian and his research team, led by Dr. Michael F. Holick, Ph.D., M.D., and supported by Boston University School of Medicine and a Boston University Ignition Award, found that skin samples exposed to RayVio's UV LED for just 0.52 minutes produced more than twice as much vitamin D3 as samples exposed to 32.5 minutes of sunlight. “We tested ultraviolet LEDs from different sources and at different wavelengths. LED showed the most significantpotential for vitamin D3 production in the shortest amount of time,” said Dr. Holick, a Professor of Medicine, Physiology and Biophysics atBoston University School of Medicine, and endocrinologist at BostonMedical Center. “This study will lead to a new generation of technologythat can be labeled as photopharmacology in which the use of LEDswith targeted wavelengths can cause specific biologic effects in humanskin to help treat and prevent chronic illnesses.” Vitamin D deficiency is associated with osteoporosis, rickets and other metabolic bone diseases and is more prevalent in northern and southern latitudes where sunlight is limited for a significant part of the year. This device for making vitamin D is ideally suited for patients with fat malabsorption syndromes including inflammatory bowel disease and gastric bypass surgery. The research shows that LEDs could be used for treating patients that are vitamin D deficient. A vitamin D3 producing UV LED device could be used on skin areas that experience less exposure to sunlight such as upper legs and arms and abdomen and back thus minimizing risk for developing non-melanoma skin cancer. The UV LED device also emits a much narrower band of UVB light and thereby decreasing likelihood of skin damage that can occur when the skin is exposed to higher wavelengths of UV radiation.
“Next to water, tea is the most consumed beverage worldwide with approximately 20 billion cups consumed daily,” which is almost 2000 olympic swimming pools. Tea has long been a staple in the diets of individuals all over the world and has been heralded for its health benefits. Lots of people have a cup of tea when they are sick, and recent studies have shown that tea might be able to prevent cancer. Much of the research about the potential anti-cancer effects of tea has focused on chemicals called polyphenols, which are the major active compounds in tea and are also responsible for the distinct flavors and aromas of tea. There are many common dietary sources of polyphenols, including berries, peppers, dark chocolate, red wine, and coffee, and they have a wide variety of health effects. These compounds are structurally diverse, but they all have multiple hexagonal, ring-like components called phenols. Different types of tea can contain different polyphenols. For instance, For instance, the major polyphenol in green tea is a catechin called (−)-epigallocatechin-3-gallate, or EGCG. Theaflavins and thearubigins are commonly found in black tea. Polyphenols are a promising candidate for advancing numerous anti-cancer innovations due to their accessibility through common dietary sources like tea and potential ability to combat cancer through both reversing epigenetic changes and improving the efficacy of cancer treatments.
If you want to watch this YouTube Video, click here: https://www.youtube.com/watch?v=IGJ7uVpnhbAMy Weight Loss Tools:Dr. Gundry's MCT Wellness: http://ref.gundrymd.com/avantiwellnessDr. Gundry's 30X Olive Oil: http://ref.gundrymd.com/AW-Olive-OilLumen Metabolic Tracker + App: Lumen: https://www.lumen.me/?fid=6051Glass Water Bottles on Amazon: https://amzn.to/3A6iQ0IWaterproof & Exercise Earbuds to use for walking or in the pool on Amazon: https://amzn.to/3KuR9lH Kettle & Fire Bone Broth on Amazon: https://amzn.to/3NDTHOASunrider Products: home.sunrider.com/avantiwellnessJoin me on my motivational transformation journey to lose 100#'s. I am using new innovative tools to see how well they work. So far so good. I am striving for progress rather than perfection.We have a Facebook Support Group called Avanti Wellness Weight Loss Motivation & Support. https://www.facebook.com/groups/562383802347215
Join us as we discuss the health benefits of a good quality Olive Oil with Tony Kasandrinos. The keywords here are “good quality.” Tony walks us through how to find a good quality olive oil and what makes it good quality to begin with. Olives are an amazing source of polyphenols. Polyphenols are reducing agents, and together with other dietary antioxidants, protect the body's tissues against oxidative stress and associated pathologies such as cancers, heart disease and inflammation. For centuries, in places like Greece, Italy, Tunisia, and Spain, good quality olive oil has been regarded as a necessary staple in the diet if you want to live long, have good overall health and vitality and a healthy gut microbiome. So where do you find “good quality” olive oil? Tony explains that if you want to derive the health benefits from olive oil, it must be grown in places where the olive trees have produced for many decades without requiring any pesticides to hurry their growth. He tells us what to look for on the labels and explains what certain buzz words mean in the olive oil industry like “product of Italy.” So get yourself a good quality olive oil and pour it on everything you eat! Episode Takeaways: The health benefits of a good quality olive oil: Optimize Heart Function Reduce Inflammation Increase Brain Function Help Maintain Healthy Weight Fight Disease Lift Mood And Lower Anxiety Smooth Digestion and Gut Microbiome Lengthen Your Life The down side to mass produced olive trees (and olive oil): Olive Trees planted in mass production are sprayed with pesticides, allowing them to grow and produce more olives at a faster pace. Pesticides are getting sprayed on the majority of olives Fruit gets bruised by machinery vs hand picked in orchids It's difficult getting it to the consumer before it's too old - look at the harvest date Most bottles won't say how old the oil is, it's typically edible but past the point of deriving any health benefits from it The much older trees remain fruitful without having to invade with pesticides Handpicked olives They are pressed (cleaned) Olive is a fruit All the polyphenols and antioxidants will start to dissipate over time Stick to organic if you can Generic olive oil has likely had many different pesticides sprayed on it Look for USDA organic labels Look for batch testing on their website What does Extra virgin mean? Extra virgin refers to the acidity level of the oil Health benefits of olive oil Polyphenols and antioxidants Brain health Heart health Bone health Hair and Skin health Increases life expectancy Will it oxidize? Olive oil will oxidize over time, with air, and light - doesn't oxidize as fast as other oils like vegetable oils Fat is good despite what you've heard Your brain and body need the right kinds of fat What about cooking with olive oil, is it safe? In greece they use it often for cooking Different olive oils have different smoke points Smoke point - if it's smoking, you are cooking it too hot What about flavored oil? Don't buy flavored olive oil, make it at home The bottles of flavored olive oil in the stores almost always use synthetic flavoring Non-consumption uses for olive oil Skin - soaps, body butter, hair care Microbiome connection Polyphenols are excellent for the microbiome Increase the growth of acromansia which is very important for metabolic health Polyphenol count is tested in the Kasandrinos on a regular basis About 1000 milligrams of polyphenols per kilogram However polyphenols do degrade in oil over time, after about 2 years polyphenols drop off considerably Can you give olive oil to kids? Babies? Yes, ideally it's organic olive oil that is less than two years old so they can benefit from the healthy compounds in it Connect with Tony: Website Instagram: @kasandrinos Facebook YouTube Connect with Kiran Krishnan and Dr. Nicole Beurkens on... Instagram: better.biome Facebook: better biome Instagram: Dr. Nicole Instagram: Kiran Krishnan Website: BetterBiome.com Website: DrBeurkens.com
Polyphenol pills counter inflammation in women on hormonal contraceptives: RCT Universidade Federal do Rio Grande do Sul (Brazil), April 7, 2022 Supplements containing a mixture of polyphenols may counter increases in pro-inflammatory markers in women of childbearing age using combined hormonal contraceptives, says a new study. The supplements, formulated with resveratrol, catechin, quercetin, chlorogenic acid and cyanidin, were also found to prevent the increases in markers of systemic oxidative stress like F2-isoprostane. “The increase in biomarkers of inflammation and oxidative stress observed in the present study were possibly caused by the use of hormonal contraceptives, as verified in the [control group], and this change was not observed in the group that used polyphenols,” wrote researchers from the Institute of Cardiology and the Universidade Federal do Rio Grande do Sul in Brazil. “Therefore, the results of this polyphenol supplementation showed that the antioxidant and anti-inflammatory effects observed in the studied population is due to the reduction in plasma levels of PGE2, supporting the conceptual hypothesis, by its action on the inflammatory cascade, probably by COX inhibition.” (NEXT) The power of kindness in improving brain health Center for BrainHealth at The University of Texas, April 11, 2022 Kindness is powerful and does not just affect the recipient's feelings—kindness can also impact an entire family's brain health. A cross-disciplinary team of researchers and clinicians from Center for BrainHealth at The University of Texas at Dallas sought to understand whether an online kindness training program improves preschooler's prosocial behaviors and their parents' resilience during the COVID-19 pandemic. (NEXT) Omega-3 supplementation could offer MCI benefits: Pilot study University of California-Los Angeles, April 10, 2022 Supplementation with a drink containing 2000 mg of omega-3 and mixed botanicals could have ‘significant' immune and biochemical effects in people that have minor cognitive impairment (MCI), new research suggests. The pilot study, published in The FASEB Journal, investigated the immune and pro- and anti-inflammatory effects of nutritional supplementation with a drink (Smartfish) that combines high levels of the omega-3 fatty acids DHA and EPA with a mixture of vitamins and botanicals including resveratrol vitamin D3, “thus targeting several facets of AD [Alzheimer's disease] pathogenesis.” (NEXT) Magic mushroom compound increases brain connectivity in people with depression after use by Imperial College London, April 11, 2022 Psilocybin, the psychedelic compound found in magic mushrooms, helps to "open up" depressed people's brains, even after use, enabling brain regions to talk more freely to one another. These are the findings of a new analysis of brain scans from close to 60 people receiving treatment for depression, led by Imperial College London's Centre for Psychedelic Research. The team behind the study believes it may have untangled how psilocybin exerts its therapeutic effects on the brain. (NEXT) Regular cycling helps patients with 'accelerated aging' disease McMaster University, April 11, 2022 A study led by McMaster University researchers has found that regular cycling can greatly improve mobility in patients with myotonic dystrophy (MD), a genetic disease that causes muscle degeneration. Senior author Mark Tarnopolsky said that cycling for 35 minutes three times a week for 12 weeks led to a 32 percent increase in overall fitness in people with MD. Patients who took part in the study also saw a 1.6-kilogram increase in their muscle massand a two percent reduction of body fat. They were also able to walk an extra 47 meters in six minutes, when tested by researchers at the end of the 12-week trial.
There is no way to avoid aging. We are all destined to grow old, get sick, and die… Or are we? Although we can't completely avoid the aging process, we sure can slow it down quite a bit. And disease? Even though it may be the “norm” for an increasing number of older Americans to succumb to chronic diseases as they age, this doesn't have to be the case for you. There is a new normal when it comes to how we age — and following these six simple steps to reverse aging naturally can help you get there. 6 Ways You Can Help Reverse the Aging Process #1: Take key supplements. Nobel Prize-winning chemist, author, and health advocate Linus Pauling said, “By the proper intakes of vitamins and other nutrients and by following a few other healthful practices from youth or middle age on, you can, I believe, extend your life and years of well-being by twenty-five or even thirty-five years.” He might have added: “And you can live those extra years with excellent and vibrant health!” Supplements (and foods, which we will talk about next) that are best for keeping your body and mind sharp must contain antioxidants. Some essential vitamins to add to your anti-aging arsenal include vitamin C and E as well as Glucosamine and Coenzyme Q10. Polyphenol-rich matcha tea, resveratrol, and collagen are three other supplements that can be age-busters as well. #2: Use the immune-boosting and anti-inflammatory support power of medicinal mushrooms. In addition, if you are serious about your anti-aging regime, you must also consider adding a medicinal mushroom supplement to your daily routine. Have you ever heard of the Japanese island of Okinawa? For generations, the population there was teeming with centenarians (people in their 100s) who were bright eyed and in great physical health. What was their secret? Eating fresh foods, spending lots of time out in nature and in their gardens, and surrounding themselves with family and friends. And, according to research conducted by the Okinawa Centenarian Study, the population also ate a large amount of various kinds of mushrooms, including shiitake and reishi mushrooms. These mushrooms have been proven to have a profound effect on the immune system and help to curb inflammatory responses. The study researchers, as well as many other studies, have linked consuming medicinal mushrooms with relief from inflammatory disease, osteo- and rheumatoid arthritis, autoimmune disorders and digestive problems, just to name a few. #3: Eat Antioxidant Rich, Anti-Aging Foods. Besides mushrooms (which can be consumed in tea, in food form, or as a supplement), fill your plate with foods that are rich in omega-3 fats such as wild caught salmon, green leafy organic vegetables that contain high numbers of phytonutrients, berries such as raspberries and blueberries that have antioxidants called anthocyanins (which have been shown to slow tumor growth as well), and healing herbs like turmeric, basil, and ginger. Want to improve your odds of living longer and living pain-free? Make it a point to also avoid all processed and GMO foods (including GMO produce), refined sugar, wheat products (especially commercially-produced breads, pastas, and baked goods), trans fats and artificial ingredients, and keep alcohol consumption to a minimum. The best diet for staying vibrant into your 70s, 80s, and beyond is the simplest kind of diet. Eat real, recognizable food and plenty of (preferably raw or lightly steamed) vegetables in a relaxed setting and drink plenty of clean, filtered water. Even when we are older, our bodies are still primarily made of water so the key is to hydrate, hydrate, hydrate! #4: Get Plenty of Sleep. Older people often have trouble sleeping, especially women in their post-menopausal years. The reasons for this are plentiful: stress and anxiety as well as hormonal imbalances can play a part. Making rest a priority can do wonders for your daily energy levels and clarity of mind. Studies have shown that individuals with sleep disorders such as “sleep apnea” and insomnia have an increased risk of cancer. Insufficient sleep has been associated with cell damage, neurological impairment, a compromised immune system, inflammation, and accelerated aging. When you get consistent, quality sleep, however, these conditions can sometimes reverse as the body is allowed to repair and restore during sleep. #5: Exercise Your Mind. You may think of activities such as doing crosswords or sudoku, learning a language or musical instrument or reading a book as ways that you can keep your mind active in later years. But these activities are just the tip of the iceberg when it comes to how you can boost your brain power. Stress-relieving and focusing activities such as meditation (and movement meditations like qi gong and forest bathing) have been proven to improve the strength and length of telomeres, stretches of DNA at the end of chromosomes which protect our genes. Telomeres keep chromosomes from fraying and clumping. Shortened telomeres are associated with aging as well as cancer and higher risk of death. A 2015 Canadian study linked evidence of longer telomere strands to meditation (when compared to those who did not meditate). In addition, activities like creative visualization, repeating affirmations, and doing something like Emotional Freedom Technique (which also clears energy channels for physical healing, according to the principles of Chinese medicine) can keep you in a positive state of mind which can aid in the slowing down of the aging process. Famed actress Sophia Lauren had it right when she said, “There is a fountain of youth: it is your mind, your talents, the creativity you bring to your life and the lives of people you love. When you learn to tap this source, you will truly have defeated age.” #6: Keep Moving! Hundreds of studies have correlated even moderate amounts of exercise with lower blood pressure, lower incidents of diabetes, lower cancer rates (sometimes up to 80 percent reduction), lower rates of heart disease, increased longevity and happiness overall. Take a walk (especially in nature), swim, do some yoga or tai chi, or dance to your favorite tune. The most important thing is that you move your body at least 3 to 4 times a week for at least 30 minutes, according to experts. In addition, if your lifestyle or profession dictates that you sit for long periods of time, make sure that you get up to stretch and move every hour at least. Your Reverse Aging “Recipe” Taking key supplements (including mushrooms for supporting your immune system), eating healthy, organic foods and drinking fresh, filtered water, getting plenty of sleep, exercising the mind, and moving the body regularly. These six actions really are the “recipe” for not only a long life, but a vibrant one as well. Slowing down the aging process and staying sharp into your hundreds like the centenarians of Okinawa is possible. It simply takes discipline and a vision of a strong and healthy you, no matter what your physical age! Resources: Organixx Clean Sourced Collagens Collagen for Your Skin: Hype or Healthy? The Healing Power of Medicinal Mushrooms – Episode 158 Organixx 7M+ Organixx Ageless Brain Sleep… The experts were wrong and what you need to know! – Episode 37 Want to Slow Down Aging? Meet Your Telomeres – Episode 145 The Tapping Solution Longevity & Anti-Aging Secrets – Episode 140 Amazon John Easterling Shares His Secrets for Optimal Brain Health – Episode 152 Can Alzheimer's and Dementia Be Prevented Naturally? Inspired Health Journey: TeriAnn Trevenen – Episode 24
There is no way to avoid aging. We are all destined to grow old, get sick, and die… Or are we? Although we can't completely avoid the aging process, we sure can slow it down quite a bit. And disease? Even though it may be the “norm” for an increasing number of older Americans to succumb to chronic diseases as they age, this doesn't have to be the case for you. There is a new normal when it comes to how we age — and following these six simple steps to reverse aging naturally can help you get there. 6 Ways You Can Help Reverse the Aging Process #1: Take key supplements. Nobel Prize-winning chemist, author, and health advocate Linus Pauling said, “By the proper intakes of vitamins and other nutrients and by following a few other healthful practices from youth or middle age on, you can, I believe, extend your life and years of well-being by twenty-five or even thirty-five years.” He might have added: “And you can live those extra years with excellent and vibrant health!” Supplements (and foods, which we will talk about next) that are best for keeping your body and mind sharp must contain antioxidants. Some essential vitamins to add to your anti-aging arsenal include vitamin C and E as well as Glucosamine and Coenzyme Q10. Polyphenol-rich matcha tea, resveratrol, and collagen are three other supplements that can be age-busters as well. #2: Use the immune-boosting and anti-inflammatory support power of medicinal mushrooms. In addition, if you are serious about your anti-aging regime, you must also consider adding a medicinal mushroom supplement to your daily routine. Have you ever heard of the Japanese island of Okinawa? For generations, the population there was teeming with centenarians (people in their 100s) who were bright eyed and in great physical health. What was their secret? Eating fresh foods, spending lots of time out in nature and in their gardens, and surrounding themselves with family and friends. And, according to research conducted by the Okinawa Centenarian Study, the population also ate a large amount of various kinds of mushrooms, including shiitake and reishi mushrooms. These mushrooms have been proven to have a profound effect on the immune system and help to curb inflammatory responses. The study researchers, as well as many other studies, have linked consuming medicinal mushrooms with relief from inflammatory disease, osteo- and rheumatoid arthritis, autoimmune disorders and digestive problems, just to name a few. #3: Eat Antioxidant Rich, Anti-Aging Foods. Besides mushrooms (which can be consumed in tea, in food form, or as a supplement), fill your plate with foods that are rich in omega-3 fats such as wild caught salmon, green leafy organic vegetables that contain high numbers of phytonutrients, berries such as raspberries and blueberries that have antioxidants called anthocyanins (which have been shown to slow tumor growth as well), and healing herbs like turmeric, basil, and ginger. Want to improve your odds of living longer and living pain-free? Make it a point to also avoid all processed and GMO foods (including GMO produce), refined sugar, wheat products (especially commercially-produced breads, pastas, and baked goods), trans fats and artificial ingredients, and keep alcohol consumption to a minimum. The best diet for staying vibrant into your 70s, 80s, and beyond is the simplest kind of diet. Eat real, recognizable food and plenty of (preferably raw or lightly steamed) vegetables in a relaxed setting and drink plenty of clean, filtered water. Even when we are older, our bodies are still primarily made of water so the key is to hydrate, hydrate, hydrate! #4: Get Plenty of Sleep. Older people often have trouble sleeping, especially women in their post-menopausal years. The reasons for this are plentiful: stress and anxiety as well as hormonal imbalances can play a part. Making rest a priority can do wonders for your daily energy levels and clarity of mind. Studies have shown that individuals with sleep disorders such as “sleep apnea” and insomnia have an increased risk of cancer. Insufficient sleep has been associated with cell damage, neurological impairment, a compromised immune system, inflammation, and accelerated aging. When you get consistent, quality sleep, however, these conditions can sometimes reverse as the body is allowed to repair and restore during sleep. #5: Exercise Your Mind. You may think of activities such as doing crosswords or sudoku, learning a language or musical instrument or reading a book as ways that you can keep your mind active in later years. But these activities are just the tip of the iceberg when it comes to how you can boost your brain power. Stress-relieving and focusing activities such as meditation (and movement meditations like qi gong and forest bathing) have been proven to improve the strength and length of telomeres, stretches of DNA at the end of chromosomes which protect our genes. Telomeres keep chromosomes from fraying and clumping. Shortened telomeres are associated with aging as well as cancer and higher risk of death. A 2015 Canadian study linked evidence of longer telomere strands to meditation (when compared to those who did not meditate). In addition, activities like creative visualization, repeating affirmations, and doing something like Emotional Freedom Technique (which also clears energy channels for physical healing, according to the principles of Chinese medicine) can keep you in a positive state of mind which can aid in the slowing down of the aging process. Famed actress Sophia Lauren had it right when she said, “There is a fountain of youth: it is your mind, your talents, the creativity you bring to your life and the lives of people you love. When you learn to tap this source, you will truly have defeated age.” #6: Keep Moving! Hundreds of studies have correlated even moderate amounts of exercise with lower blood pressure, lower incidents of diabetes, lower cancer rates (sometimes up to 80 percent reduction), lower rates of heart disease, increased longevity and happiness overall. Take a walk (especially in nature), swim, do some yoga or tai chi, or dance to your favorite tune. The most important thing is that you move your body at least 3 to 4 times a week for at least 30 minutes, according to experts. In addition, if your lifestyle or profession dictates that you sit for long periods of time, make sure that you get up to stretch and move every hour at least. Your Reverse Aging “Recipe” Taking key supplements (including mushrooms for supporting your immune system), eating healthy, organic foods and drinking fresh, filtered water, getting plenty of sleep, exercising the mind, and moving the body regularly. These six actions really are the “recipe” for not only a long life, but a vibrant one as well. Slowing down the aging process and staying sharp into your hundreds like the centenarians of Okinawa is possible. It simply takes discipline and a vision of a strong and healthy you, no matter what your physical age! Resources: Organixx Clean Sourced Collagens Collagen for Your Skin: Hype or Healthy? The Healing Power of Medicinal Mushrooms – Episode 158 Organixx 7M+ Organixx Ageless Brain Sleep… The experts were wrong and what you need to know! – Episode 37 Want to Slow Down Aging? Meet Your Telomeres – Episode 145 The Tapping Solution Longevity & Anti-Aging Secrets – Episode 140 Amazon John Easterling Shares His Secrets for Optimal Brain Health – Episode 152 Can Alzheimer's and Dementia Be Prevented Naturally? Inspired Health Journey: TeriAnn Trevenen – Episode 24
There is no way to avoid aging. We are all destined to grow old, get sick, and die… Or are we? Although we can't completely avoid the aging process, we sure can slow it down quite a bit. And disease? Even though it may be the “norm” for an increasing number of older Americans to succumb to chronic diseases as they age, this doesn't have to be the case for you. There is a new normal when it comes to how we age — and following these six simple steps to reverse aging naturally can help you get there. 6 Ways You Can Help Reverse the Aging Process #1: Take key supplements. Nobel Prize-winning chemist, author, and health advocate Linus Pauling said, “By the proper intakes of vitamins and other nutrients and by following a few other healthful practices from youth or middle age on, you can, I believe, extend your life and years of well-being by twenty-five or even thirty-five years.” He might have added: “And you can live those extra years with excellent and vibrant health!” Supplements (and foods, which we will talk about next) that are best for keeping your body and mind sharp must contain antioxidants. Some essential vitamins to add to your anti-aging arsenal include vitamin C and E as well as Glucosamine and Coenzyme Q10. Polyphenol-rich matcha tea, resveratrol, and collagen are three other supplements that can be age-busters as well. #2: Use the immune-boosting and anti-inflammatory support power of medicinal mushrooms. In addition, if you are serious about your anti-aging regime, you must also consider adding a medicinal mushroom supplement to your daily routine. Have you ever heard of the Japanese island of Okinawa? For generations, the population there was teeming with centenarians (people in their 100s) who were bright eyed and in great physical health. What was their secret? Eating fresh foods, spending lots of time out in nature and in their gardens, and surrounding themselves with family and friends. And, according to research conducted by the Okinawa Centenarian Study, the population also ate a large amount of various kinds of mushrooms, including shiitake and reishi mushrooms. These mushrooms have been proven to have a profound effect on the immune system and help to curb inflammatory responses. The study researchers, as well as many other studies, have linked consuming medicinal mushrooms with relief from inflammatory disease, osteo- and rheumatoid arthritis, autoimmune disorders and digestive problems, just to name a few. #3: Eat Antioxidant Rich, Anti-Aging Foods. Besides mushrooms (which can be consumed in tea, in food form, or as a supplement), fill your plate with foods that are rich in omega-3 fats such as wild caught salmon, green leafy organic vegetables that contain high numbers of phytonutrients, berries such as raspberries and blueberries that have antioxidants called anthocyanins (which have been shown to slow tumor growth as well), and healing herbs like turmeric, basil, and ginger. Want to improve your odds of living longer and living pain-free? Make it a point to also avoid all processed and GMO foods (including GMO produce), refined sugar, wheat products (especially commercially-produced breads, pastas, and baked goods), trans fats and artificial ingredients, and keep alcohol consumption to a minimum. The best diet for staying vibrant into your 70s, 80s, and beyond is the simplest kind of diet. Eat real, recognizable food and plenty of (preferably raw or lightly steamed) vegetables in a relaxed setting and drink plenty of clean, filtered water. Even when we are older, our bodies are still primarily made of water so the key is to hydrate, hydrate, hydrate! #4: Get Plenty of Sleep. Older people often have trouble sleeping, especially women in their post-menopausal years. The reasons for this are plentiful: stress and anxiety as well as hormonal imbalances can play a part. Making rest a priority can do wonders for your daily energy levels and clarity of mind. Studies have shown that individuals with sleep disorders such as “sleep apnea” and insomnia have an increased risk of cancer. Insufficient sleep has been associated with cell damage, neurological impairment, a compromised immune system, inflammation, and accelerated aging. When you get consistent, quality sleep, however, these conditions can sometimes reverse as the body is allowed to repair and restore during sleep. #5: Exercise Your Mind. You may think of activities such as doing crosswords or sudoku, learning a language or musical instrument or reading a book as ways that you can keep your mind active in later years. But these activities are just the tip of the iceberg when it comes to how you can boost your brain power. Stress-relieving and focusing activities such as meditation (and movement meditations like qi gong and forest bathing) have been proven to improve the strength and length of telomeres, stretches of DNA at the end of chromosomes which protect our genes. Telomeres keep chromosomes from fraying and clumping. Shortened telomeres are associated with aging as well as cancer and higher risk of death. A 2015 Canadian study linked evidence of longer telomere strands to meditation (when compared to those who did not meditate). In addition, activities like creative visualization, repeating affirmations, and doing something like Emotional Freedom Technique (which also clears energy channels for physical healing, according to the principles of Chinese medicine) can keep you in a positive state of mind which can aid in the slowing down of the aging process. Famed actress Sophia Lauren had it right when she said, “There is a fountain of youth: it is your mind, your talents, the creativity you bring to your life and the lives of people you love. When you learn to tap this source, you will truly have defeated age.” #6: Keep Moving! Hundreds of studies have correlated even moderate amounts of exercise with lower blood pressure, lower incidents of diabetes, lower cancer rates (sometimes up to 80 percent reduction), lower rates of heart disease, increased longevity and happiness overall. Take a walk (especially in nature), swim, do some yoga or tai chi, or dance to your favorite tune. The most important thing is that you move your body at least 3 to 4 times a week for at least 30 minutes, according to experts. In addition, if your lifestyle or profession dictates that you sit for long periods of time, make sure that you get up to stretch and move every hour at least. Your Reverse Aging “Recipe” Taking key supplements (including mushrooms for supporting your immune system), eating healthy, organic foods and drinking fresh, filtered water, getting plenty of sleep, exercising the mind, and moving the body regularly. These six actions really are the “recipe” for not only a long life, but a vibrant one as well. Slowing down the aging process and staying sharp into your hundreds like the centenarians of Okinawa is possible. It simply takes discipline and a vision of a strong and healthy you, no matter what your physical age! Resources: Organixx Clean Sourced Collagens Collagen for Your Skin: Hype or Healthy? The Healing Power of Medicinal Mushrooms – Episode 158 Organixx 7M+ Organixx Ageless Brain Sleep… The experts were wrong and what you need to know! – Episode 37 Want to Slow Down Aging? Meet Your Telomeres – Episode 145 The Tapping Solution Longevity & Anti-Aging Secrets – Episode 140 Amazon John Easterling Shares His Secrets for Optimal Brain Health – Episode 152 Can Alzheimer's and Dementia Be Prevented Naturally? Inspired Health Journey: TeriAnn Trevenen – Episode 24
There is no way to avoid aging. We are all destined to grow old, get sick, and die… Or are we? Although we can't completely avoid the aging process, we sure can slow it down quite a bit. And disease? Even though it may be the “norm” for an increasing number of older Americans to succumb to chronic diseases as they age, this doesn't have to be the case for you. There is a new normal when it comes to how we age — and following these six simple steps to reverse aging naturally can help you get there. 6 Ways You Can Help Reverse the Aging Process #1: Take key supplements. Nobel Prize-winning chemist, author, and health advocate Linus Pauling said, “By the proper intakes of vitamins and other nutrients and by following a few other healthful practices from youth or middle age on, you can, I believe, extend your life and years of well-being by twenty-five or even thirty-five years.” He might have added: “And you can live those extra years with excellent and vibrant health!” Supplements (and foods, which we will talk about next) that are best for keeping your body and mind sharp must contain antioxidants. Some essential vitamins to add to your anti-aging arsenal include vitamin C and E as well as Glucosamine and Coenzyme Q10. Polyphenol-rich matcha tea, resveratrol, and collagen are three other supplements that can be age-busters as well. #2: Use the immune-boosting and anti-inflammatory support power of medicinal mushrooms. In addition, if you are serious about your anti-aging regime, you must also consider adding a medicinal mushroom supplement to your daily routine. Have you ever heard of the Japanese island of Okinawa? For generations, the population there was teeming with centenarians (people in their 100s) who were bright eyed and in great physical health. What was their secret? Eating fresh foods, spending lots of time out in nature and in their gardens, and surrounding themselves with family and friends. And, according to research conducted by the Okinawa Centenarian Study, the population also ate a large amount of various kinds of mushrooms, including shiitake and reishi mushrooms. These mushrooms have been proven to have a profound effect on the immune system and help to curb inflammatory responses. The study researchers, as well as many other studies, have linked consuming medicinal mushrooms with relief from inflammatory disease, osteo- and rheumatoid arthritis, autoimmune disorders and digestive problems, just to name a few. #3: Eat Antioxidant Rich, Anti-Aging Foods. Besides mushrooms (which can be consumed in tea, in food form, or as a supplement), fill your plate with foods that are rich in omega-3 fats such as wild caught salmon, green leafy organic vegetables that contain high numbers of phytonutrients, berries such as raspberries and blueberries that have antioxidants called anthocyanins (which have been shown to slow tumor growth as well), and healing herbs like turmeric, basil, and ginger. Want to improve your odds of living longer and living pain-free? Make it a point to also avoid all processed and GMO foods (including GMO produce), refined sugar, wheat products (especially commercially-produced breads, pastas, and baked goods), trans fats and artificial ingredients, and keep alcohol consumption to a minimum. The best diet for staying vibrant into your 70s, 80s, and beyond is the simplest kind of diet. Eat real, recognizable food and plenty of (preferably raw or lightly steamed) vegetables in a relaxed setting and drink plenty of clean, filtered water. Even when we are older, our bodies are still primarily made of water so the key is to hydrate, hydrate, hydrate! #4: Get Plenty of Sleep. Older people often have trouble sleeping, especially women in their post-menopausal years. The reasons for this are plentiful: stress and anxiety as well as hormonal imbalances can play a part. Making rest a priority can do wonders for your daily energy levels and clarity of mind. Studies have shown that individuals with sleep disorders such as “sleep apnea” and insomnia have an increased risk of cancer. Insufficient sleep has been associated with cell damage, neurological impairment, a compromised immune system, inflammation, and accelerated aging. When you get consistent, quality sleep, however, these conditions can sometimes reverse as the body is allowed to repair and restore during sleep. #5: Exercise Your Mind. You may think of activities such as doing crosswords or sudoku, learning a language or musical instrument or reading a book as ways that you can keep your mind active in later years. But these activities are just the tip of the iceberg when it comes to how you can boost your brain power. Stress-relieving and focusing activities such as meditation (and movement meditations like qi gong and forest bathing) have been proven to improve the strength and length of telomeres, stretches of DNA at the end of chromosomes which protect our genes. Telomeres keep chromosomes from fraying and clumping. Shortened telomeres are associated with aging as well as cancer and higher risk of death. A 2015 Canadian study linked evidence of longer telomere strands to meditation (when compared to those who did not meditate). In addition, activities like creative visualization, repeating affirmations, and doing something like Emotional Freedom Technique (which also clears energy channels for physical healing, according to the principles of Chinese medicine) can keep you in a positive state of mind which can aid in the slowing down of the aging process. Famed actress Sophia Lauren had it right when she said, “There is a fountain of youth: it is your mind, your talents, the creativity you bring to your life and the lives of people you love. When you learn to tap this source, you will truly have defeated age.” #6: Keep Moving! Hundreds of studies have correlated even moderate amounts of exercise with lower blood pressure, lower incidents of diabetes, lower cancer rates (sometimes up to 80 percent reduction), lower rates of heart disease, increased longevity and happiness overall. Take a walk (especially in nature), swim, do some yoga or tai chi, or dance to your favorite tune. The most important thing is that you move your body at least 3 to 4 times a week for at least 30 minutes, according to experts. In addition, if your lifestyle or profession dictates that you sit for long periods of time, make sure that you get up to stretch and move every hour at least. Your Reverse Aging “Recipe” Taking key supplements (including mushrooms for supporting your immune system), eating healthy, organic foods and drinking fresh, filtered water, getting plenty of sleep, exercising the mind, and moving the body regularly. These six actions really are the “recipe” for not only a long life, but a vibrant one as well. Slowing down the aging process and staying sharp into your hundreds like the centenarians of Okinawa is possible. It simply takes discipline and a vision of a strong and healthy you, no matter what your physical age! Resources: Organixx Clean Sourced Collagens Collagen for Your Skin: Hype or Healthy? The Healing Power of Medicinal Mushrooms – Episode 158 Organixx 7M+ Organixx Ageless Brain Sleep… The experts were wrong and what you need to know! – Episode 37 Want to Slow Down Aging? Meet Your Telomeres – Episode 145 The Tapping Solution Longevity & Anti-Aging Secrets – Episode 140 Amazon John Easterling Shares His Secrets for Optimal Brain Health – Episode 152 Can Alzheimer's and Dementia Be Prevented Naturally? Inspired Health Journey: TeriAnn Trevenen – Episode 24
EXHILARATED LIFESTYLE: HEALTH & VITALITY Can 1 or 2 tablespoons a day of High Phenolic Extra Virgin Olive Oil turn your health around? Clinical trials say YES! In this condensed but comprehensive guide to Polyphenol-Rich EVOO for Health, discover the answers to... What defines Polyphenol rich Extra Virgin Olive Oil? How is it rated? What are the health benefits? How do I use it? How do I care for it? What do I look for to buy it? Links to Relevant Research
With so much energy discourse centered around nutrition, I'm grateful for people such as Dr. Steven Gundry. He looks beyond food and investigates the full spectrum of energy production variants, including light consumption and environmental disruptors, as well as the food energy vampires that are probably staples in your diet. If you needed reminding that your body is an intelligent organism that's designed to be challenged, Dr. Gundry's research and book, The Energy Paradox, is the alarm call you've been waiting for. The truth is it's high time we re-calibrated how to do things. For too long, we humans have been coasting through life, eating ourselves into a stupor and starving ourselves from sleep, sun, and clean foods (no, kale smoothies don't count). Let's change that, shall we? 11:24 — Light and Energy Levels Gaining ATP from sun exposure Why you're sleepy and hungry all the time How you can eat your sunscreen 22:24 – Energy Triggers for the Body Hot/cold exposure and energy production Rethinking omega-3 and vitamin E consumption Sleep for recovery and “brainwashing” Eating windows before bed Energy disruptors How antibiotics kill off your microbiome 45:50 — Mitochondria and ATP production Why modern society is in an energy gridlock How to not overwhelm your mitochondria function The supplements you should be taking for an energy boost Mitochondria dysfunction 53:21 — Why Lectins Are a No Go The food enemies out there How different cultures detox lectins preparing food Connecting food patterns with our body's function Compressing your eating cycles to enjoy treats How LMNT helps me fast Polyphenol-rich olive oil More about this episode. Watch it on YouTubez JOIN MY NEW ONLINE EMF HOME SAFETY MASTERCLASS! Visit lukestorey.com/emfmasterclass to join. Only $149! Are you aware of the dangers of EMF exposure in your home, but have no idea where to start when it comes to finding, and fixing them? Are you concerned about your exposure to the current 3G, 4G, and 5G wireless networks now activated in most major cities? Have you attempted to test the levels yourself using EMF meters you found online and ended up confused and frustrated? EMFs (electromagnetic frequencies) are one of the most toxic elements in our living and work environments. Due to the technical nature of accurately testing for them – and the training required to do so properly – many of us resign ourselves to the fact that we just have to accept them and the consequences they bring in order to use the modern technology we depend on. But you don't have to. In this seven-part video documentary series, you will follow world-renowned building biologist Brian Hoyer as he tests an entire home, room by room, to determine the source and level of every known type of EMF. By the end of this series, you will not only be thoroughly educated on the various types and sources of EMF commonly found in homes but also of the many mitigation tools and techniques available thanks to the cutting-edge technologies. Visit lukestorey.com/emfmasterclass to join. Only $149! Connect with Luke on social media to learn how to take your lifestyle to the next level, plus catch exclusive live interviews & events: INSTAGRAM - @lukestorey // instagram.com/lukestorey/ FACEBOOK - facebook.com/MrLukeStorey/ TWITTER - @MrLukeStorey // twitter.com/MRLUKESTOREY YOUTUBE - youtube.com/c/LukeStorey THIS SHOW IS BROUGHT TO YOU BY: JOOVV. It's no secret that 2020 was a challenging year for many people. So, in 2021, I'm focusing even more on my personal wellness routine and overall mental and physical health and one of the non-negotiables in my life is getting my daily dose of healthy light, which is why I've been using Joovv red light therapy devices for years now. And Joovv's new Generation 3.0 devices are sleeker and lighter, with all the same power you'd come to expect. They also include some cool features like Recovery Plus mode, giving you an extra healing boost that optimizes the recovery process. They've also got a new feature called ambient mode, which uses lower intensity light to support your sleep and circadian rhythms and to help counteract all of the artificial blue light that keeps you up at night that might be present in your home. You can get an exclusive discount on Joovv Generation 3.0 devices at www.Joovv.com/luke. AND… INSIDE TRACKER. When you do what you love – like running, like racing, like enjoying the great outdoors – you want to do it for life. InsideTracker can help. InsideTracker was founded in 2009 by leading scientists in aging, genetics, and biometrics. Using their patented algorithm, InsideTracker analyzes your body's data to provide you with a clear picture of what's going on inside you and to offer you science-backed recommendations for positive diet and lifestyle changes. Then InsideTracker tracks your progress every day, every step of the way toward reaching your performance goals and living a longer, healthier life. You can get 25% off the entire InsideTracker store for a limited time by going to: insidetracker.com/luke. AND… ONNIT. Ease into a flow state and “get in the zone” with Onnit's Alpha BRAIN nootropic: the dietary supplement that helps support cognitive functions, including memory, mental processing, speed, and focus. Fire up your potential – and save 10% – by heading to onnit.com/luke. HELP SUPPORT THIS SHOW! Love the Show? You'll really love Luke's Master Market Online Store! It's a win-win! Get direct links to all of Luke's hand-picked biohacking and health products all in one place, get exclusive discounts, and support the show by making purchases through the web store >> SHOP NOW. Other ways to support: SUBSCRIBE >> Apple Podcasts + Stitcher + Google Podcasts + Spotify LEAVE APPLE PODCASTS REVIEW >> Simple step-by-step instructions SHARE >> Spread the word! Tell your family, friends, neighbors, and all your social pals Resources Website: gundrymd.com Instagram: @gundrymd Read: The Energy Paradox: What to Do When Your Get-Up-and-Go Has Got Up and Gone Pre-order Alyson Charles's book: Animal Power: 100 Animals to Energize Your Life and Awaken Your Soul Related Shows #336: “How to Create Superhuman Energy Immunity” w/ Ian Clark
Bienvenidos Ah, this is where no, sorry, I screwed it up. So I got really nervous. It's like the lights came on. Okay.Remember, we're actually saying that Yeah.Okay, there we go. Three. You ready? Oh, yeah. Okay. Three, two on bmnh Oh, god check project. Your soy, Eric. Esta Dr. Brown,Dr. Brown Como estas Morgana, grassy asmita story super emotional o por el podcastone tenemos en invitado fantastical. gephi ancestors that podcast story.Sylvia done this style of video.Wait, wait, wait, wait, wait, guys, I can't speak English. Oh, okay.Oh, thank goodness cuz I'm pretty sure that's all the Spanish Eric knew. And banyo I got that down too. So why don't we Why don't we start over and just take it from the top in English. Now that we know that our wonderful guest who lives in Spain to learn all about That's right. actually speaks English. Okay, probably should have figured that out. Before we started the podcastguys. I'm gonna start all over. So welcome gut check project fans and KB MD health family. It's now episode number 49. I'm Eric. This is my awesome co host Dr. Kenneth Brown. And today we've got an incredible special guest that I tried. I you know, I can't I tried Spanish.I tried. You did so Eric. Eric dusted off his eighth grade Spanish. He was trying to impress Silvia you know, I mean, we're both a little nervous because what what we have on the podcast today is super special. Everybody has heroes in their life and Silvia is my hero because she is a poly phenol expert. She's getting her doctorate in specifically the polyphenols that we use on Tron teal. So she knows more about it than anybody I've ever met. And I'm so excited and nervous that we actually tried to speak in her native her native language.I'm just embarrassed that but there'll be a welcome to the show. Welcome to go check project. Thank you so much for makingvideos.She said y'all she's trying tolearn some Texas now first of all, Silvia get us up to speed you're living in Granada Spain. What is going on there? You You WhatsApp to me You guys got a little earthquake situation right?Yeah, we were we were we were that weights. But now where? We stay better here. Fortunately, visitation is is better.You said it so calm. When you just WhatsApp you're like, oh, things are good. Here. We're dealing with a lot of earthquakes. Thanks for asking. Tough in Spain.We used to.So this is this is super cool. Thank you so much for coming on the podcast. I have followed your work. Some of the work that you have done as the lead author I have used we've discussed it on multiple podcasts. If you've seen Episode 47 Episode 46 multiple other episodes, we always refer to the large stable polyphenols and how they get broken down by the microbiome and the purse that articles that always reference. This is the author of those articles. Sylvia Molino, who is I almost called you doctor but you're almost a doctor, right? almost almost.Nice. Nice. Hey, sowhy don't you tell us a bit about your background how you ended up there? What's going on? Everything Everything about Silvia Molino.Okay, so I am a biologist. I got my master's degree in Italy. But I the my train sheep here in Granada, where we started working with embitter. And they're just in implementation. And I fell in love with this argument. And then in one Congress, I met Michaela Battaglia is the CEO of silica team, that Britain is a b2b company that produced what the word leader is producing tannins that are polyphenols, sure, and he got interested in my work. So we started collaborating and and then we had the idea to create a new project to investigate the application of tannins in humans. And so I just started with my PhD working on that, and I'm still working on that and we have continuing on thatYeah, that's awesome. So when you when you first hopped into it, were polyphenol something that drew your interest in their immediate applications for for health or is it something that just kind of just happened over time? What was it that drew you into wanting to study about polyphenols?Well, um, I ever I always have been interesting in polyphenols about more in general about nutraceutical okay, because I believe that we could treat some diseases or some dysfunction with natural product, because actually, we are using a lot of synthetic treatment, but they were discovered from studying nature. So sometimes I think that we could go back to the power of nature. And in this case, 10 isabsolutely Well honestly, the timing really couldn't be better and where we find ourselves not just in the United States, but obviously all the way around the world for us to find and escape from synthetic solutions to what otherwise are just natural problems. And if probably we were consuming more polythene hauls as a you know, for the entire earth we would be in better shape. Yeah.Repeat that.Eric was just saying that you're exactly right. We have always we have a we have felt that the consumption of polyphenols is what what we're lacking in the western American diet. If we had more polyphenols we would have better health.Yeah, yeah, for sure. Yeah,I was just gonna say you use the word nutraceutical, which is, which is interesting because we've, we've coined that term, but what does nutraceutical mean to you as a scientist?Wow, it's a hard question for me and you're just starting over is a solution that could be assumed for from a person by person. Like it will be a part of the natural diet like it will be a tude. Okay, so something more natural.Okay, so a functional food, nutraceutical interesting, a molecule that can have health benefits, but it's found in nature?Yeah, exactly.And so you through your research, you found that these beautiful molecules called polyphenols have hold all this potential to be bioactive and possibly a nutraceutical for humans. So, for anybody that has not heard this, can you explain in your words what a poly phenol is?Well, polyphenols are molecules if we can find in a network, obviously, the name derives from the chemical structure and they are well known for the multiple by activities beneficial by activities. First of all, they are antioxidant, they are what non antioxidant. And this is a super important characteristic of them because they help us to counteract the action of the oxidative stress. The oxidative stress is a normal events that we have that happens in our bodies, and can lead to a lot a lot of diseases and a lot of problems.So leading to like inflammation, is that kind of what you're talking about there with long exposures of oxidative stress?Well, can you repeat, please?Sure. Are you saying that oxidative stress leads to inflammation, like more inflammation around tissues? Is that what you're saying?Yeah, for sure. Well, normally we our normal metabolism, I produce free radicals. Okay. And this normal normal process of power rally, but what happens if we produce a high amount of, of these free radicals, and it's normal to breathe in sometimes to produce a lot of free radicals. And the causes could be external factors, such as stress or bad diet, for example, we have some endogenous mechanisms of our body to counteract these production of oxidative stress done by the free radicals, but these are not sufficient and are not not the most of the times. So we need to intake somehow. From from external hub. And in this case, we have to take antioxidant. And antioxidant we can find, for example, polyphenols, other one on the oxygen, for example, our could be vitamin C, Vitamin E. But from our study, for example, we could discover that time knees, among other 43 years has exert a higher activity than this well known molecules, such as vitamin C. So we could, in this case, it is a smaller amount of external external compounds and not enough to not have to have the same effect. So it's so great.Okay, now it makes it makes a lot of sense. Very congruent.Yeah, it absolutely does. So when we talk about these polyphenols and you brought up tannins, which is what your research has been in, we know that people that are discussing polyphenols, the molecules that make vegetables colorful, there are different sizes and different characteristics as a researcher that you have figured out, can you explain the differences in sizes, characteristics and antioxidant capabilities? Just real grossly and then we'll talk about some of your research because I think it's so cool. Getting the foundation like this.Yeah, I'm on point he knows Wait, what polyphenols are a huge group of molecules. Among them we can find tannins and tannins are one known for the characteristic to the capacity to bind and precipitate protein alkaloids and carbohydrates among other molecules. Among tannins, we can have hydrolyzable tannins and condensed hominids, the realizable Chinese are called like that because they are the they are either realizable, with a lot of facility with weak weak assets. Among these group, we could find Gulf tannins, and a lot of tannins, depending on the different structure nucleus that we can find in the in the in the compounds. And when we don't have a generalizable tannins we have so condensed tannins destructors are characterized by the presence of Brandis entities that can form a big big structure like with with bending blocks. Just explain in an easier way. And sometimes we could have also an association between advisable timings and condensed tannins. And so we have complex diamonds and the name was explained the complexity of the molecules because they we have in this case, big big big molecules.Sothe these molecules that are larger Danny's the alternates, and the contents on this are characterized by the presence of a lot of hydroxyl groups. And these groups are responsible of the antioxidant, the great antioxidant capacity of the planets. So it's also so important.So let me pause you right there. So you're saying that the what makes these polyphenols unique the polyphenols under the big umbrella, or the large polyphenols proanthocyanidins which are in the class of tannins. They have tremendous antioxidant capacity because they have the hydroxyl groups, a bunch of them all around the hydroxyl group is the oh ah that you'll see in those chemistry structures are always there, hydroxyl. So you're saying that the the amount of hydroxyl groups is very important to the antioxidant component?Yeah, definitely. And they can exert they are different activity in different way. For example, and thanks to the hydroxyl groups, they could they have the capacity to come in the free radicals. But in other cases they could have, they could have also our endogenous antioxidant system, for example, they can use the production of antioxidant enzymes that we can produce.Like, is that like super oxide? dismutase? Is that one of them? The anti turning onto what is it? What is an example of a endogenous antioxidant enzyme that the tenant turns on?Well, well, what I was saying before what what I was what I was explaining before About our endogenous response to the oxidative stress, we produce some antioxidant enzymes, okay, for example supersedure, dismutase, or catalase, okay? So we know that tannins among all therefore the females can in us increase the production of these enzymes, so reducing that oxidative stress in our body.So it's twofold. It can basically bind to these weak acids, as well as make our bodies produce more of the enzymes to help basically combine these free radicals.Onto production. Yeah,that's awesome. And I think that once we get to your studies, we're gonna find it. That's not that's just the tip of the iceberg. That'sjust tip of the iceberg. So everybody, so over here, Sylvia, there's shows like Dr. Oz, or he's always talking about different diets, and they're always talking about different compounds. They rarely discuss it as a polyphenol, but they'll have a show on green tea extract egcg, or they'll have a show on reservatrol. Or they'll do these different things. But these are all polyphenols. But what people don't understand is this complex science that you're an expert in, which is what I love, because I can sit with my patients, and explain to them why these these particular polyphenols whether in diet, we always ask everybody during their diet or through a supplement, do multiple things. And the tip of the iceberg is the potent antioxidant.Yeah, totally. Because the the oxidative startles then could lead to multiple diseases, that will be chronic diseases or chronic inflammation. So in this case, we can counteract a lot of problems. Systemic levels, or at local level.Now, the research when you when you teamed up with Michaela, had you been doing research on these polyphenols? Or did you take some of the research that Silva team had done with the animal studies? Because they've been involved with cattle in the wine industry for so many years? Was this? Was this a hard step to move from some of that research over to the data that we're going to talk about with your different studies?Well, they have a great experience with with animals, they were they are working with animals from 15 years, maybe more or less. But it's true. Try to start working with with humans is always different, because the information that we have in animals could have, but it's not a reality is not atranslate, just because it happens in an animal doesn't mean it will happen in a human.It's true. I wanted to say that. Okay, thank you. So, we're here, I started working with an in vitro system, just to study in the deep in the, in this Moore's more particles, because I wanted to know, how these molecules are acting and how they are metabolized. Because there are a lot of literature about tannins, but there, there still be big lack about the information because it's totally new this argument, this issue. So I first started working on the antioxidant activity of different extract. And then I proceeded to digest and ferment in vitro, just simulating that the digestion of the human body to try to drain to discover what's happening in our body when we intake tannins,so I'm sorry, no, no. Well, how long have you been then working with Mikayla and Sylvia team then because what I'm curious about is since you started doing your research, and kind of what your observation is, or how you've seen the world's view possibly change or be influenced by powerful studies regarding polyphenols and their benefits with health what what have you seen while you've been working with Michaela, and has the has the are people more receptive to that idea?Well, I started a six years ago, okay. And when I started, I have to be clear, I didn't know anything about tunings. I knew just the tunings about wine, wine, I'm Italian It was a total discover for me. Um, yeah. From my studies, I think that we discover a new product that could resolve a lot of problem. Above all, I think this is a great way discovered about InDesign. It is, I think the solution for all the problem, I don't know, maybe could be strange to understand. But I discovered a lot a lot of properties of time knees, because fundamentally, they have a prebiotic action. So they function like a fiber, they help our digestion, they can modulate the composition of our microbiota, and through that they can regulate our inflammatory status, our oxidative status, so it's perfect.I think that's so incredible, because what we always hear about is just the antioxidant potential. So here from a marketing standpoint, a lot of people try and sell supplements, they go, this is an antioxidant, this has the highest antioxidant capacity. What you have discovered in your research is, these beautiful large molecules do so much more than that, which you just touched on right there, which is it functions like a prebiotic, meaning that it feeds our own microbiome. And we know that when we have a diverse microbiome, you end up having a healthier body all around. So when I started treating my patients with our combination of the cabrito, and chestnut, and we were seeing incredible results, I knew what was happening in the short term when we were getting the bacteria, the bacterial overgrowth. That's why we developed it. But so many of my patients felt better and better while remaining on it. And now I can explain to them because of your research, what's actually going on. And that's what's so cool. And that's what's so neat that most of the research that is done and you've You know, this are done on smaller phenolic compounds, those ones that we talked about. So they always talk about the same ones over and over course, the 10 reservatrol curcumin those, you took a step back and said, Wait a minute, let's find out what happens when we look at these larger molecules. Definitely. And you use the really cool term because I'm going to start using this building blocks the molecules just a large building block. Yeah. Which is awesome. The when, before we get into your research there, I had to plow through trying to trying to prepare for a paper and some and a podcast of really big article called the immunomodulatory, anti inflammatory antioxidant effects of polyphenols a comparative review on the parental compounds and their metabolites. It's like a 50 page article where all they did is show that no every time you take one of these polyphenols, it does more and it gets broken down into more things. And it was like really thick. And then you I found your article, which do you have more questions? Because I think one of the coolestone of the things that you said that we've said on the show multiple times is you said the word prebiotic, and that's still not really a commonly used word here, at least in the States. Would you mind Silvia kind of explaining what you view is a prebiotic?Yeah. Normally people know that term probiotic. And sometimes there's like a mistake between pre and probiotics. So I could explain it a probiotic. It is like a strange this, our bacteria normally are beneficial bacteria that we can intake. Normally with yogurt or the products. A prebiotic is something that is before the bacteria. So if something is a substance, or for example, fibers that could act on the on the composition of our microbiota. So we are not going to change the composition of our microbiota by taking some external strain of bacteria, but we just want to moderate what we have with prebioticmakes sense. So basically, it's it's almost like the perfect food for the bacteria that we already have. Right? Yeah.If we give to our microbiota, like a good food to to grow well, right.What generally speaking since you've been doing research on this over here, probiotics. It's a massive industry. But just recently, a lot of data is coming out that probiotics probably don't do as much as we used to think, mainly because many of these probiotics that we purchase, don't make it to the colon where your microbiome is, what are with through your research? I'm just curious what your opinion is on probiotics in the use in humans? Well,I think that each person has his own microbiota, and each person needs a specific strain of probiotic. And it's so difficult to do that. Because normally, what we can find in the supermarket is like last bifidobacterium more lactobacillus but is so general, we don't know if that strain is the right strain for us. In the other way, it prebiotic always is good, because it's helping our our on microbiota. So we are going to solve the problem for sure. Well, and then there are other technical problems, for example, the probiotics are not so resistant. So sometimes we can intake a product with probiotics, but they don't have done work. So good.That makes sense.Yeah, that's we've we've done a little bit of research on this, my personal belief is, is that when, when we look at probiotics, we at least know that certain things like a spore based probiotics stays in the spore form. And there is clinical data to show that it can make it to the colon where then it wakes up. And if it's got the prebiotic like a polyphenol with it, the combination helps both of them improve the microbial diversity, or basically they work together.Actually, there's a paper that is in publication. So then I can send it to you. I always working with in vitro, they just send fermentation, I could demonstrate that the intake of tannins caught it improve the diversity of the of the microbiota.It's perfect. That is huge. Hey, out of curiosity, if this paper since you've been doing some of that research, is it possible that not only will the tenants improve the diversity, but will it help raise good bacteria and lower the type of bacteria that we know can create problems?Yeah, we have to know that tannins are really our molecules produced our secondary metabolites from plants. And these metabolites are produced from plants as defense. So these cues are produced to counteract the action of bad guys, such as bacteria, bad bacteria, or other other external factors. And and if we intake tennis is up in the same field. So they are able to detect the bad guys, the bad bacteria. And I don't want to say to kill them that reduce the amount or the activity. And the other part on the other part, they can increase the activity and the functionality of the code guy or the good bacteria.That is awesome. Nobody has said that before like that.No, they haven't. And in fact, it makes perfect sense, because it's not like and Sylvia said this earlier, it's normal for us to have reactive oxygen species, right. But in small amounts, what do tannins do, they keep us from having too much. So you're saying it's not eliminating all of the quote unquote, bad bacteria, it's more or less delivering balance, where we need balanceis a modulation.That's beautiful. It's allowing mother nature to do what it's what it wants to you. We hinted at it at the beginning of the show, but what happens in the pharmaceutical industry is they go, Oh, we want this molecule, let's make a drug out of this tiny molecule and not taking into account that when you give the body what it wants, it will use what it needs to make sure that it keeps you in balance.Yeah, I think that the great thing about the extra toe I'm working with from siba team is that they are Phyto complex. We are not working with just one specific molecule. We are working with a group of molecules so we have multiple action and multiple effect.Let's say you have I have a paper on this specifically and and it really, really piqued my interest. And the reason is because you illustrated and then essentially gave the How to on why a larger parent molecule, which basically would have more of these smaller polyphenols is actually what your body wants, because simply, it begins to pull apart the polyphenols as it needs to use them. Is that is that right? Is that how Am I understanding that correctly?Yeah, yeah, it's correct. and here we can find it another super characteristic often is because we can see that they could art at a local level in the InDesign as big molecule. And these big molecules are the molecules that are that are going into in contact with with a good microbiota. But when they are metabolized, they could give form to smaller metabolites. And these modern metabolites are the responsible doses possible of the systemic effects. Okay. They could pass them through the intestinal barrier, and then extra day they fashion and system 11 in the audience, there isn'tthat kind of what you called post biopsies. Soyeah, that's we're referring to those metabolites as post biotics. So it's the post biotic or the metabolites or the break? Absolutely. So can you do me a favor? I'm, can you explain, I don't know if you can see that. But your little summary, the diagram, but this is what's so cool. And this is what separates Silvia from everybody else, she developed this super eloquent model, can you explain what you did with this, because it's so neat. With in vitro digestion?Well, the in vitro digestion and fermentation are two basic steps. First of all, we have the digestion. In this case, we are mimicking what happened, what's happening in the mouse in the stone much and during this time, we mimic the temperature pH, enzymatic condition that we find in the in the mouth, and then in so much and then in time, okay, then what we obtain from the digestion we take apart, and we put it in contact with the microbiota within inoculum. And then we'll add a permanent state. And then from that, we obtain our sample that we are going to study. So from from these records, we have a resembling matters of that of the human digestion.So in your diagram, so cool, you mixed one to one in the oral phase with salivary fluid, salivary amylase at a certain pH, then you mix it in the gastric phase with gastric fluid pepsin. So a digestive enzyme at a certain Ph. And then in the intestinal phase, you mixed it with intestinal fluid, including pancreatic fluids, like trypsin, and bile, that's fantastic. So all three phases of digestion, then you separated those, and you took one of them, and then you fermented it, to show what happens in the colon.So this part is very important, which is is important to us. And we wrote a paper, I think, in a few days will be published in, in natural protocols.That's incredible. So then you took this fermented you first of all, you took the digestion part, and then you analyze that and then you took the fermented part, you analyzed it, when you say analyzed it, what did you do to analyze it?Well, we could perform every type of analysis, I dedicated my studies about the antioxidant activity of of tannins, just to see how can the digestion and then the fermentation could affect the antioxidant activity exerted by by by tannins, and then I try to understand how these big molecules could be metabolized by our body. So how the structures could be affected by the action of the enzyme enzymes or digestive enzymes and then how these molecules could be affected by the action of the gut microbiota.Okay. Makes sense. So essentially, she was just trying to show the what's going to happen all the way through the entire phase of having a polyphenol.Yeah. Which is so cool because nobody has done this yet, looking at the literature, this is the one thing that I've wanted to see for so long. What happens with these large tannins through digestion and through fermentation? So after fermentation? What did you notice? Like What Did you see when these large building blocks were digested and then fermented?Well, after digestion, and it was a bit surprising that the large molecules, they're still there. But then, after the action of that gut microbiota, we could have said that a lot of small molecules a small metabolized were forming, thanks to the action of the of the of the bacteria bacteria. Okay. Yeah. So we could see the formation of smaller molecules, typical from the idealized Bhutanese or from the combat standings. So we will see an increase in the presence of Corsetti in a gcg, galley kassig, or ellagic acid.This is this is awesome, because just not to veer far. But right now stateside, what people are hearing about on podcast trying to find solutions for people maybe who can't get access to a vaccine, or they have difficulty because they're overly exposed to public, they're getting lots of guidance on utilizing certain polyphenols, like course attended cetera, to function as zinc on a force. But what I'm hearing you say is that you can actually still get that same course. And they'll have your body disassemble a much larger parent molecule or parent poly phenol. Yeah. And your body will essentially pull apart exactly as much as it needs. Is that right?Yeah.Can you do that?Yes, no, no, it's fine. I What I'm saying is, is that your what you illustrated in here, you were able to find these metabolites of the bacteria was able to make use of the poly phenol. Yeah, some of those included the corset in which, over here stateside, now people are hearing about corsten. And its ability to help people with antiviral activity. And what I'm hearing you say, from your research, you can actually get plenty of course it in by having a larger poly phenol that actually has it inside. Is that right?Yeah, actually, we know that our extracts for use from from Suba team are very effective for antiviral activity. And we started to with a big trial clinical trial in Argentina, and what does is trying to give a supplement to COVID patients. And we have the first results, we don't have all the results, but we have the first results about that. And we could have served at first that the passion supplemented with tunings Beside that, then the typical therapy registered and a decrease of the inflammatory status, we registered the crease of for example of some indicators like TNF alpha.That sounds very familiar. And again,very, very, very familiar. Still doing what's really interesting is that this is the first time that anybody has discussed the fact that over here, there's lots of supplements, and the supplements are Oh, get this green tea extract, oh, get this ellagic acid, which will help produce your alisson get this course written. And so I have so many patients that have 20 different bottles in front of them. And they're doing this and then when we realize that no, once again, that's almost a smaller version of what the pharmaceutical companies are doing. It's like, Oh, this molecule was studied here. So I'm gonna go buy that molecule. But when you give the large stable molecule, Mother Nature's secret weapon, then your microbiome will kick off these smaller molecules like this corseted. Now, something that's interesting, I did reference that first study that was really thick. What they did is they did, they did mass spec on these different polyphenolic compounds, including reservatrol, including quercetin and including tumeric. And what they showed is those are poorly absorbed, and they end up having to be broken down also. So it isn't like taking the smaller molecule is a shortcut, it still has to go. The beauty of using a large tannin like this is the prebiotic effect which improves the microbial spectrum. And then the broader the microbial spectrum, the more of these beneficial, smaller phenolic compounds are going to get 100%.And this is just like a bi directional relationship between tannins and microbiota because tannins in some way, we could say that feed the microbiota as prebiotic, by then the other way that that feed, the Fed microbiota is going to metabolize them.A bi directional relationship bi directional relation tannins and by the micro. Yeah, it makes sense. They need each other.Yeah. Frequently, I think of tannins in the microbiome, like the bidirectional relationship that Eric and I have in our friendship. Yeah, I need him he needs me.If it weren't for him, bringing AGI patients, I would just be putting people to sleep for nothing.Yeah, they would just go to sleep and nobody was doing anything. This is what's so cool about this is can you just explain really quick, just so that people don't take your word for it yet, you ended up doing some pretty cool chemistry to determine what molecules were there. So what did you do when you did the fermented how you were able to show that quarter 10 was kicked off that your lifting was kicked off that egcg was kicked offwhat I had to perform before an extraction of the polyphenols. And when I had the sample, I perform an analysis on a uplc ms. That is a huge instrument that allows our allow us to identify exactly every single molecules.So the detectable so she had definitive proof that they were there.That's awesome. Right there. I'm looking at her mask. Right there. Got it in the article.Mass Spectrometry. Yeah,yes. I love that. That is what's that's the thing that I think is going to be the biggest game changer understanding that through your science, really, you can get these other beneficial products through one parent molecule, the building block. And that's what I try to tell my patients like, Well, why don't we take the largest, most stable tannins, right, put them together? And then as you take that, that will not only feed your microbiome, but you'll also produce these other things. And then the metabolites, the other metabolites like, oh, short chain fatty acids?Yeah. Because we don't have us only just the metabolites deriving from the receptors of the big structures. We also have the other secondary metabolites that arise from the action of microbiota. We know from my researches and from other scientific literature, that tan is good in us both microbiota to produce short chain fatty acids. These small molecules are so important for us because they exert a lot of activities, they will be absorbed, and they their main activity is an anti inflammatory effect. But also they are super important for them. Past military maintenance of the sad part of what leaving what been leaving for this house. Yeah,I mean, we're basically on about item number 17. on why polyphenols daily are critically important. And Silvia put it in here in a paper that anybody can read. I mean, this is awesome. 100%, when when you did this article, this is the thing I've been trying to explain to patients for so long. And you showed it very eloquently here, you also have another published study, which is pretty eloquent in itself. And this one is a little bit more related to the thing that we're both very passionate about, which is the brain gut access. Yeah, my my goal as a physician, eventually is to make it so that we protect the brains of people we know that inflammation results in all kinds of different diseases. And you actually published a paper as the lead author, polyphenols in dementia from molecular basis to clinical trials. How did you decide to do How did you decide to do a review article on dementia? That's really cool. That's right in our wheelhouse also, definitely.Well, at the moment, I was working in a lab in Italy. They were specializing in dementia, and they wanted to publish something about about that, and they proposed me to write a paper. And I think that I had inside already that the love for pony feels. At the moment I was working with polyphenols of grapefruit,grapefruit. Oh, yeah.So I started searching something and then I just decided that it's dementia and polyphenols, I started to find a lot of source. So interesting literature and then I could find also clinical trial. So I decided to construct the paper from the molecular basis to explain exactly what's happening and its molecular level until to the clinical trials. What happens in the passions?Well, it's a it's a powerful piece, because essentially, you're outlining that somebody who has had dementia, it's probably have long exposures to inflammation. And then in the paper, you're essentially showing how or why I guess polyphenols are critical.So So in this particular paper, you were looking at the literature. So this was a review. So the literature that was available, looked at those different molecules that were already talking about reservatrol, curcumin and things, and I have to I love how you address this head on you said that the bioavailability of curcumin tumeric, which everybody talks about all the time is very low, because it is poorly absorbed and rapidly metabolized them eliminate and eliminate it. Here one study that talked about this, you go in to describe how reservatrol has very low bioavailability. Everything that you're talking about is exactly what this other article did, where it showed that even these smaller phenolic compounds do that. So we know that there's evidence to show that this can help in dementia. How does it help in dementia, though, let's just so when in your review, how did you figure out that it helped to prevent dementia or assist those people with dementia?What the mechanisms are with are always the same. First of all, we have the antioxidant activity and anti inflammatory activity. What I can say now, after some years, I could say that could be related also to the modulation of the microbiota, because we know that almost 70% of the immune system is in the in dangerous time. Okay, so by regulating the microbiota, by maintaining maintaining a good status in the intestine, and reducing the inflammation there, we could then regulate also the inflammation all over the body and also reducing for sure, the inflammation that can lead to dementia. So it's everything is related.So she used some pretty common terms that you and I have talked about quite a bit, right. Um, thing about Oh, NF Kappa beta. Yeah. CRP lippo, polysaccharides cyclooxygenase. pathway. So that is that definitely summarizes Do we have this thing, open that up real quick, like Sophia, this is what Eric and I did last time. That's all about inflammation and polyphenols and where they help.Yeah, so we I, I drew first and then we realized how bad it was. So we found a young child, a kindergartener walking down the street, better than I did, so we paid them to do this. So it's done by some children.It was another one of those bi directional relationships.bi directional relationship. So this is this is so exciting. Here's why you're doing research, you have shown that the cause of dementia is actually due to inflammation, which we talk about all the time, all the time, diseases, inflammation, cause of cancers inflammation, we have, I have a lot of friends that participate in a lot of combat sports. I have a lot of friends that are former football players. So I have this whole community of people that have had traumatic brain injuries, which I think could really benefit from stuff like this. We know that because of the diet, people have a pro inflammatory diet correct. And you know, when we look at this, that the group of people that I treat a lot are people that have intestinal inflammation through bacterial overgrowth, poor diet, one of the most common things that they talk about or if I asked them is brain fog, or fatigue or anxiety. Yeah. And now we knowthe reason I found in nature tour I can I can send it to you to interesting papers talking about some products that have been developed with tannins for the productivity for the mentality. Oh, Gordon, explain why but I guess it we could do it.But I mean, isn't that something though, they probably stumbled upon it. Not really knowing. And quite honestly, it's your review and some of your other research that's starting to show people the why, which is critically important. Why, you know, why does someone want to do what it is that we're doing with polyphenols and Sylvia's? Honestly, paving the way on on the why it's very powerful.we all we all have heroes. Sylvia, you're my hero, you are proving the things that that we have been trying to I've been trying to explain to my patients. And then now I can go low. I'll refer you to this article. This is why this is also why I think it's important to have a good diet, but also the long term strategy of the longer that you allow your body to access these tannins. Definitely the more your microbial diversity, the more you will block the inflammatory cascade. Yeah,well, inflamed inflammation long term is not an overnight thing. So in order to repair our bodies, you need to consume healthy polyphenols for a long period of time. And then your body gets used to having the tools that it needs to provide your body with the short chain fatty acids or the Euro lessons or the course it cetera, for you to repair and control inflammation it makes, it makes a lot of sense.Yeah, totally.Okay, Sylvia, so I had, I did clinic this morning, and I have a series of patients, and I told them, I said, Don't worry, I'm having one of the smartest scientists in the entire world on the show today. This is an interesting thing, because of your research, I think we can help some of these people. I have a series of patients that have had their colons taken out for various diseases, either, that, for whatever reason, they have no colon. So now they have no microbiome. So now, in fact, I had a patient. My last patient said something really interesting to me. She loves she loved taking artron teal, she said she'd never felt better. And then due to some adverse events, she has an ileostomy so that she's not connected to her colon. And she said today, she's like, I just don't I don't get it. I'm not feeling as good as I used to. And I'm like I do. Because we're not, we're not breaking these down. We're not fermenting them in the way that they should be. So my task to you, how do we develop something for people that do not have the capability of fermenting foods, tannins, prebiotics, to have these beneficial to handle this opportunity to decrease the inflammatory cascade? What do you what pops in your mind of how we can figure something out for these people that don't have access to the microbiome? Am I saying that right?Well, just to understand your question, you are meaning don't have access to microbiome in the senate don't have a white coat microbiota, orno, they have had their colons removed completely. No, yeah. So no large intestine Yeah.Okay. Okay.One of ourone of our prior guests, one of our prior guests, Angie, she said, You got to figure this out with I'm gonna call you Dr. Sylvia. Because you're you're almostyou can go me almost doctorWell, does he go Tada, Silvia de la luna Casa gasi. Dora, that's almost doctor, I'm catchingup.No, but it's something with with your with your research that shows that people with a colon will have a a more beneficial response to prebiotics and to these polyphenols. So is it possible that fermenting them first and then giving that as an absorbablethis could be a possibility. We called what the product should be developed. But it's, it's okay. We could do it in laboratory The name of this product are post biotic as we were saying before, sure. So we could generate directed the metabolites from from Danny's from the big structures in laboratory by fermenting them with an old microbiota outside the body. And then give the to the patient the post biotic so all the fermented Tell the lightsbe interesting to at least try. Because if without having the colon, you have to kind of wonder though, if the passage is quite the same when it comes to only having a small battle. That makes sense.It's extremely, it's extremely complex, and we're seeing it more and more. And so I'm just wondering how, you know, figuring something like this is it's a small community.I can't hear you anymore.Oh, that's because he was on mute. I'm sorry. Well, I was just saying that it is a small community, but people that it's insult to injury, if you have a disease, ulcerative colitis, Crohn's disease, a severe dysmotility, whatever, and you have your colon taken out? That's hard enough. Yeah. And then from then on, how do you make sure that you are able to produce these metabolites, which decrease your inflammatory pathway? Sure.And you need them systematically?Yeah. It's just something that I dealt with this morning. And I said, I have the person has the answer. How long do you think it'll take you to develop this product? And then get it back to me so that I can start helping my patients? I told him, I told him about a week. Yeah, cuz gosee looked at I Silvia can do anything.As soon as I finish my thesis, I can start with the project.And nothing doesn't do it at all. Well,this is exciting. This is super cool. Yeah. Sylvia, your your research is incredible. I think that you're just getting warmed up, I think that you have shined a light in an area that many of us can start looking at and start talking about in a very scientific way. And it isn't just Oh, go out and buy this marketing product over here. We want to we want to educate people through science. And that's what you're doing over here. So 100, right.And I just think it's so cool that you are able to where people are already turning to polyphenols, and we mentioned ecgc and in quercetin before, and we've all been trying to compete on how do we get our body to use these nice, awesome poly phenol molecules. And really, you just took a step back and said, Guys, you really want this bigger one. Because by using this bigger poly phenol, your body is actually going to get a better bioavailability of everything that you think that you need. And it's, it's, it's awesome. And it put it into practice. And quite honestly, this is a theme that we've seen before, over and over and over again, where we tried to give women who are who are in need of a folic acid, and they put folic acid in a little, a little pill. So they're while they're pregnant, that they don't have, you know, some some birth defects. But the truth is your body wants full eight, not necessarily folic acid. So once again, it's it's the bigger molecule that it's natural that your body wants. And what you did is you just basically took that same science and just blasted it into polyphenols. I think it's awesome.We're going to, we're going to get you hooked up, we had a meeting with the author of the cert diet, which in your article, you actually describe how these polyphenols were turned on the sirtuin pathway as well. And so that is a whole nother aspect of almost an epigenetic process that goes on with it. But the other really cool thing is you talked about how these polyphenols increased nitric oxide both Eric and I like to exercise so we take our polyphenols for the nitric oxide capability. So all right, Cassie dotata Silvia does Michaela let you do anything. What do you like to do for fun when you're not always working on your thesis?You You talked to us?Because that's because I'm speaking Spanglish. gasi Dr. Sylvia? Yeah.Are Spanish or English.We, I want to know does other than working on your thesis and working from a Khaleda? What do you like to do for fun?This is my phone.My phone?Well, I in my free time, I'm an athlete. I'm a triathlete. Oh,yeah. Are you taking your polyphenols while you train and recover?Working on me to develop new supplements with Thomas.Oh, look at that. Nice. Yeah.Yeah, they are so useful. So for first of all to people, because for sports that requires a lot of exercise like triathlon for example. The the body is always always trust and the development of oxidative stress and inflammation is huge. So We are used to take just supplements with carbohydrates or proteins they are giving us just micronutrients but they are not thinking about macronutrients or polyphenols, some some molecules that could help us to reduce the fatigue and to help us to recovery.What's the most challenge? What's the most challenging event that you've done in a triathlon? Have you done like an Iron Man orI'm sorry to interrupt you soyou can fit those in a little bit quicker to understand.I come from autism I before when when I was young, I was a sprinter. So for me, an Olympic distance of triathlon is just like a mortal now.I think that your research is really important because Eric tried doing some triathlons also. And he understood the power of polyphenols. But the only one that he had read about was reservatrol. So he was drinking wine the entire time that he was doing the triathlondata, remember?Before to cycle in, it's not the road.Well, I don't remember any of it. So it's okay.Well, Sylvia, thank you so much for joining the gacek project. This is exactly what I wanted to talk about. You did an incredible job. Your your research is amazing. And I feel like you're just getting warmed up. I feel like she's going to continue to uncover a lot of different things.Yeah, what an awesome show to have you join us and and for all of you as a gut check project, like normal, we will put Sylvia's research in the show notes so that if you would like to see her own articles yourself or some of the others that they can reference. That way, you know, that we're not just we're not just speaking, it's, there's there's lots of powerful information in here. And I just can't thank you enough Sylvia, for making time to hop on with us today. It'sbeen it's been awesome. And if you're, if you're listening to this, as always, you know, share this with people, it's super important information that this is an incredible opportunity to have somebody like sylviane explaining this intricate science. So if you know somebody that has intestinal health problems, if the autoimmune problems, inflammation, possibly risking dementia, things like that, this is really important stuff that they all need to hear,definitely. Or if you think that you're in the market for trying some type of new polyphenol or course it's in or you're going to green tea to get ecgc maybe just reconsider re listen to this particular episode. And I think that we can help you with artron to find a much better larger poly phenol, that Believe it or not, Silvia here has researched thoroughly. She knows it very, very well. So,Sylvia, can we be can we be a sponsor for your next triathlon? I'll try to just give her the whole logos everywhere. AndI think that the corporate office is gonna love the fact that you've already committed so I guess we'reworking for my new uniform so we can talk about it. Oh, I'msorry. I think we're a little mistake. Oh, and I mean, sponsor, the only sponsors we get are people that actually get tattoos.Yeah, yeah, you we. He wants to give you a tattoo of altro until it's kind of a permanent sponsorship.That's awesome, Sylvia. So much. Hey, don't hang up yet. But everyone else thank you so much for joining. Gotcha project number 49. And like I said, we'll make everything available to everything else to answer it.No, I'm just loving it. Loving everything. I thought it would be. All right.Thank you all very much, Silvia. Don't go anywhere. Bye bye.
Gary takes on the real issues that the mainstream media is afraid to tackle. Tune in to find out the latest about health news, healing, politics, and the economy. George Orwell and 1984: How Freedom Dies Orwell's final warning - Picture of the future The Efficacy of Olive Leaf Extract on Healing Herpes Simplex Virus: A Randomized Double-blind Study Lorestan University of Medical Sciences (Iran), January 29, 2021 Herpes simplex virus (HSV), as a common infection in healthy individuals, is treated symptomatically, but drug resistance and the side effects of drugs have drawn the attention of researchers to complementary medicine. Olive Leaf Extract (OLE) has antiviral effects that may treat HSV. The current study aimed to compare the clinical effects of OLE and Acyclovir on HSV-1. Methods This randomized double-blind clinical trial was conducted on 66 patients who had already been diagnosed with HSV-1. The participants were randomized into two groups, receiving 2% OLE cream or 5% acyclovir cream five times a day for six days. The symptoms were evaluated before, and three and six days after the interventions. Data were analyzed using the SPSS software through the Kolmogorov-Smirnov test, chi-squared, t-test, and repeated measures ANOVA. Results The results showed clinical symptoms decreased in both groups during the study and both medications were effective in the treatment of HSV-1. However, the OLE group experienced less bleeding (P=0.038), itching (P=0.002), and pain (P=0.001) on the third day as well as less irritation (P=0.012), itching (P=0.003) and color change (P=0.001) on the sixth day compared to the acyclovir group. The treatment course for participants in the OLE group was shorter than in the acyclovir group (P = 0.001). Conclusion The evidence from these trials suggests the OLE cream is superior in the healing of episodes of HSV-1 over the acyclovir cream. Future studies are recommended to investigate if OLE could be an adjunct to acyclovir treatment. How vitamins, steroids and potential antivirals might affect SARS-CoV-2 Study indicates that some vitamins, steroids and antivirals could bind to the Spike protein, and may inhibit virus infectivity, whereas high cholesterol may enable the virus University of Bristol (UK), January 29, 2021 Evidence is emerging that vitamin D - and possibly vitamins K and A - might help combat COVID-19. A new study from the University of Bristol published in the journal of the German Chemical Society Angewandte Chemie has shown how they - and other antiviral drugs - might work. The research indicates that these dietary supplements and compounds could bind to the viral spike protein and so might reduce SARS-CoV-2 infectivity. In contrast, cholesterol may increase infectivity, which could explain why having high cholesterol is considered a risk factor for serious disease. Recently, Bristol researchers showed that linoleic acid binds to a specific site in the viral spike protein, and that by doing so, it locks the spike into a closed, less infective form. Now, a research team has used computational methods to search for other compounds that might have the same effect, as potential treatments. They hope to prevent human cells becoming infected by preventing the viral spike protein from opening enough to interact with a human protein (ACE2). New anti-viral drugs can take years to design, develop and test, so the researchers looked through a library of approved drugs and vitamins to identify those which might bind to this recently discovered 'druggable pocket' inside the SARS-CoV-2 spike protein. The team first studied the effects of linoleic acid on the spike, using computational simulations to show that it stabilizes the closed form. Further simulations showed that dexamethasone - which is an effective treatment for COVID-19 - might also bind to this site and help reduce viral infectivity in addition to its effects on the human immune system. The team then conducted simulations to see which other compounds bind to the fatty acid site. This identified some drugs that have been found by experiments to be active against the virus, suggesting that this may be one mechanism by which they prevent viral replication such as, by locking the spike structure in the same way as linoleic acid. The findings suggested several drug candidates among available pharmaceuticals and dietary components, including some that have been found to slow SARS-CoV-2 reproduction in the laboratory. These have the potential to bind to the SARS-CoV-2 spike protein and may help to prevent cell entry. The simulations also predicted that the fat-soluble vitamins D, K and A bind to the spike in the same way making the spike less able to infect cells. Dr Deborah Shoemark, Senior Research Associate (Biomolecular Modelling) in the School of Biochemistry, who modelled the spike, explained: "Our findings help explain how some vitamins may play a more direct role in combatting COVID than their conventional support of the human immune system. "Obesity is a major risk factor for severe COVID. Vitamin D is fat soluble and tends to accumulate in fatty tissue. This can lower the amount of vitamin D available to obese individuals. Countries in which some of these vitamin deficiencies are more common have also suffered badly during the course of the pandemic. Our research suggests that some essential vitamins and fatty acids including linoleic acid may contribute to impeding the spike/ACE2 interaction. Deficiency in any one of them may make it easier for the virus to infect." Pre-existing high cholesterol levels have been associated with increased risk for severe COVID-19. Reports that the SARS-CoV-2 spike protein binds cholesterol led the team to investigate whether it could bind at the fatty acid binding site. Their simulations indicate that it could bind, but that it may have a destabilising effect on the spike's locked conformation, and favour the open, more infective conformation. Dr Shoemark continued: "We know that the use of cholesterol lowering statins reduces the risk of developing severe COVID and shortens recovery time in less severe cases. Whether cholesterol de-stabilises the "benign", closed conformation or not, our results suggest that by directly interacting with the spike, the virus could sequester cholesterol to achieve the local concentrations required to facilitate cell entry and this may also account for the observed loss of circulating cholesterol post infection." Professor Adrian Mulholland, of Bristol's School of Chemistry, added: "Our simulations show how some molecules binding at the linoleic acid site affect the spike's dynamics and lock it closed. They also show that drugs and vitamins active against the virus may work in the same way. Targeting this site may be a route to new anti-viral drugs. A next step would be to look at effects of dietary supplements and test viral replication in cells." Alison Derbenwick Miller, Vice President, Oracle for Research, said: "It's incredibly exciting that researchers are gaining new insights into how SARS-CoV-2 interacts with human cells, which ultimately will lead to new ways to fight COVID-19. We are delighted that Oracle's high-performance cloud infrastructure is helping to advance this kind of world-changing research. Growing a globally-connected community of cloud-powered researchers is exactly what Oracle for Research is designed to do." Researchers find melatonin is effective against polycystic kidney disease Concordia University (Canada), January 26, 2021 A hormone commonly associated with sleep-wake regulation has been found to reduce cysts in fruit flies, according to Concordia researchers. It's a finding that may affect the way we treat some kidney diseases and reduce the need for kidney transplants. In a new paper published in the journal Molecules, alum Cassandra Millet-Boureima(MSc 19) and Chiara Gamberi, affiliate assistant professor of biology, write that melatonin was found to reduce cysts in the renal tubules of fruit flies. These tubules are also found in more complex mammals, including humans, where they are called nephrons. This study, which builds on previous studies by Millet-Boureima and Gamberi, was co-authored by Roman Rozencwaig and Felix Polyak of BH Bioscience in Montreal. The researchers hope that their findings can be applied to treating people suffering from autosomal dominant polycystic kidney disease. ADPKD is a genetic chronic and progressive disease characterized by the growth of dozens of cysts in the nephrons. It is incurable and affects approximately 12.5 million worldwide. Similarities big and small Because nephrons in vertebrates are embedded in other tissue, the researchers experimented on Drosophila -- the common fruit fly. "Drosophila conserves many of the renal pathway components found in vertebrates and have anatomically isolated renal tubes," Gamberi explains. "With microdissection, we can isolate the tubules and conduct biochemical and molecular analysis." The researchers bred fruit flies bearing the Bicaudal C gene mutation. It is known to cause kidney cysts in all manner of living beings, from flies to frogs to mice to humans. Over 18 days, Millet-Boureima administered melatonin to 50 Drosophila and ethanol to a control group. She then dissected the flies and scored their cysts, a process yielding a cystic index. She found that the melatonin-treated flies had much fewer and smaller cysts than the control. Because Millet-Boureima was skilled at dissecting the insects and evaluating the recovered renal tubules, she was able to avoid bias in the count. She was also able to distinguish three separate sections of the Drosophila tubule, each with its own unique function, and assign the cysts to a particular section. After testing several compounds on the same family of cells, she observed different activities along the length of the tubule. The researchers realized that they could potentially develop targeted treatment depending on the location of the cysts in a patient's nephrons. "Biologically speaking, this has a lot of potential that we will obviously develop," Gamberi says. Helping without harming Though Gamberi says melatonin has not been previously used to treat PKD, she does think it holds some promise. PKD is a chronic disease, so treatment cannot include any toxic components. This rules out chemotherapy and tumour-killing antineoplastics used in oncology, for instance. However, melatonin is entirely non-toxic and shares certain properties with antineoplastics and anti-inflammatory agents. "We know from oncology that melatonin has two effects when it is administered with chemotherapy," Gamberi explains. "First, it acts as a drug adjuvant to the chemotherapy, making it work more effectively against cancer cells. Second, it appears to protect healthy cells from the toxicity of the chemotherapy. Basically, melatonin increases the specificity of the chemotherapy. We hope that it can have a similar positive effect when used with an anti-ADPKD drug like tolvaptan, which can damage the liver." The researchers are keen to share their findings as quickly as possible. "I hope there will be more research on the drugs we tested and that we get more results that will help the PKD community," Millet-Boureima says. Gallic acid is a dual alpha/beta-secretase modulator that reverses cognitive impairment and remediates pathology in Alzheimer Saitama Medical Center (Japan), January 20, 2021 According to news reporting from Saitama, Japan, research stated, “Several plant-derived compounds have demonstrated efficacy in pre-clinical Alzheimer’s disease (AD) rodent models. Each of these compounds share a gallic acid (GA) moiety, and initial assays on this isolated molecule indicated that it might be responsible for the therapeutic benefits observed.” Higher concentrations of GA are found in blueberry, blackberry, strawberry, plums, grapes, mango, cashew nut, hazelnut, walnut and tea. The news correspondents obtained a quote from the research from Saitama Medical Center, “To test this hypothesis in a more physiologically relevant setting, we investigated the effect of GA in the mutant human amyloid beta-protein precursor/presenilin 1 (APP/PS1) transgenic AD mouse model. Beginning at 12 months, we orally administered GA (20 mg/kg) or vehicle once daily for 6 months to APP/PS1 mice that have accelerated Alzheimer-like pathology. At 18 months of age, GA therapy reversed impaired learning and memory as compared with vehicle, and did not alter behavior in nontransgenic littermates. GA-treated APP/PS1 mice had mitigated cerebral amyloidosis, including brain parenchymal and cerebral vascular beta-amyloid deposits, and decreased cerebral amyloid beta-proteins. Beneficial effects co-occurred with reduced amyloidogenic and elevated nonamyloidogenic APP processing. Furthermore, brain inflammation, gliosis, and oxidative stress were alleviated. We show that GA simultaneously elevates alpha- and reduces beta-secretase activity, inhibits neuroinflammation, and stabilizes brain oxidative stress in a pre-clinical mouse model of AD. We further demonstrate that GA increases abundance of a disintegrin and metalloproteinase domain-containing protein 10 (ADAM10, Adam10) proprotein convertase furin and activates ADAM10, directly inhibits beta-site APP cleaving enzyme 1 (BACE1, Bace1) activity but does not alter Adam10 or Bace1 transcription. Thus, our data reveal novel post-translational mechanisms for GA.” According to the news reporters, the research concluded: “We suggest further examination of GA supplementation in humans will shed light on the exciting therapeutic potential of this molecule.” This research has been peer-reviewed. Black cumin’s anti-inflammatory potential may have airways/asthma benefits: RCT University College London, January 27, 2021 Supplements containing oil from black cumin (Nigella sativa) may improve asthma control and lung function, says a new study. The seed and oil of Nigella sativa have been used extensively in traditional medicine in many Middle Eastern and Asian countries for the treatment of a range of conditions, including some immune and inflammatory disorders. The new study, published in Phytotherapy Research , found that one gram per day of the oil for four weeks led to significant improvements in scores of asthma control and a “remarkable reduction of peripheral blood eosinophil count,” wrote the authors “Eosinophil cell plays a major role in asthma inflammation, and blood eosinophil count is considered to be a vital biomarker in asthma trials. To our knowledge, this is the first [randomized, double-blind, placebo-controlled trial] that showed a significant reduction of blood eosinophilia by [Nigella sativa oil (NSO)] among asthmatic patients.” Scientists from University College London (UK) and King Abdulaziz University (Saudi Arabia) recruited 80 asthmatics and randomly assigned them to one of two equal groups. The participants received either capsules containing 500 mg of NSO twice per day or placebo for four weeks. Data from the 60 people who completed the study (10 dropouts in each group) indicated that the black cumin supplement was associated with significant improvements in mean score on the Asthma Control Test, compared to placebo. Black cumin oil products are commercially available through brands such as Life Extension. Structure-function claims made on the products include: “Modulates key regulators of inflammation” In addition, the black cumin group also experienced a significant decrease in blood eosinophils: −50 versus 15 cells/microliter. A non-statistically significant improvement in lung function, measured as forced expiratory volume in 1 second, was also associated with the black cumin supplements. “The NSO supplementation appeared to be effective in enhancing the control of asthma symptoms with a trend in pulmonary function improvement,” wrote the researchers. “These findings may provide an evidence for the potential benefits of NSO supplementation in the clinical management of asthma. “Future studies should follow patients for a longer period and use additional outcomes to validate the benefits of NSO in asthma.” LSD may offer viable treatment for certain mental disorders McGill University (Quebec), January 26, 2021 Researchers from McGill University have discovered, for the first time, one of the possible mechanisms that contributes to the ability of lysergic acid diethylamide (LSD) to increase social interaction. The findings, which could help unlock potential therapeutic applications in treating certain psychiatric diseases, including anxiety and alcohol use disorders, are published in the journal PNAS. Psychedelic drugs, including LSD, were popular in the 1970s and have been gaining popularity over the past decade, with reports of young professionals claiming to regularly take small non-hallucinogenic micro-doses of LSD to boost their productivity and creativity and to increase their empathy. The mechanism of action of LSD on the brain, however, has remained a mystery. Studies in mice provide clues To conduct their study, the researchers administered a low dose of LSD to mice over a period of seven days, resulting in an observable increase in the sociability of the mice. "This increased sociability occurs because the LSD activates the serotonin 5-HT2A receptors and the AMPA receptors -- which is a glutamate receptor, the main brain excitatory neurotransmitters -- in the prefrontal cortex and also activates a cellular protein called mTORC 1," explains Danilo De Gregorio, PharmD, PhD, who is a postdoctoral fellow in the Neurobiological Psychiatry Unit at McGill and the study's first author. "These three factors, taken together, promote social interaction in mice, which is the equivalent of empathy and social behaviour in humans." The researchers note that the main outcome of their study is the ability to describe, at least in rodents, the underlying mechanism for the behavioural effect that results in LSD increasing feelings of empathy, including a greater connection to the world and sense of being part of a large community. "The fact that LSD binds the 5-HT2A receptor was previously known. The novelty of this research is to have identified that the prosocial effects of LSD activate the 5-HT2 receptors, which in-turn activate the excitatory synapses of the AMPA receptor as well as the protein complex mTORC1, which has been demonstrated to be dysregulated in diseases with social deficits such as autism spectrum disorder," as specified by Prof. Nahum Sonenberg, Professor at the Department of Biochemistry of McGill University, world renowned expert in the molecular biology of diseases and co-lead author of the study. Using the cutting-edge technique of optogenetics, a technique where genes for light-sensitive proteins are introduced into specific types of brain cells in order to monitor and control their activity precisely using light signals, the researchers observed that when the excitatory transmission in the prefrontal cortex is de-activated, the prosocial effect of LSD was nullified, highlighting the importance of this brain region on the modulation of the behavioural effects of LSD. Moving forward to apply the findings to humans Having found that LSD increases social interaction in mice, the researchers are hoping to continue their work and to test the ability of LSD to treat mutant mice displaying the behavioural deficits similar to those seen in human pathologies including autism spectrum disorders and social anxiety disorders. The hope is to eventually explore whether micro-doses of LSD or some novel derivates might have a similar effect in humans and whether it could also be a viable and safe therapeutic option. "Social interaction is a fundamental characteristic of human behaviour," notes the co-lead author Dr. Gabriella Gobbi, Professor in the Department of Psychiatry at McGill and psychiatrist at the McGill University Health Centre. "These hallucinogenic compounds, which, at low doses, are able to increase sociability may help to better understand the pharmacology and neurobiology of social behavior and, ultimately, to develop and discover novel and safer drugs for mental disorders." Polyphenol-rich virgin olive oil reduces insulin resistance and liver inflammation and improves mitochondrial dysfunction University of Naples (Italy), January 28, 2021 Studies from University of Naples Federico II Describe New Findings in Insulin Resistance (Polyphenol-rich virgin olive oil reduces insulin resistance and liver inflammation and improves mitochondrial dysfunction in high-fat diet fed rats) A new study on Endocrine System Diseases and Conditions - Insulin Resistance is now available. According to news reporting originating in Naples, Italy, research stated, "Virgin olive oil is an essential component of the Mediterranean diet. Its antioxidant and anti-inflammatory properties are mainly linked to phenolic contents." The news reporters obtained a quote from the research from the University of Naples Federico II, "This study aims to evaluate the beneficial effects of a polyphenol-rich virgin olive oil (HPCOO) or olive oil without polyphenols (WPOO) in rats fed high-fat diet (HFD). Male Sprague-Dawley rats were divided into four groups based on the different types of diet: (I) standard diet (STD); (II) HFD; (III) HFD containing WPOO, and (IV) HFD containing HPCOO. HPCOO and WPOO induced a significant improvement of HFD-induced impaired glucose homeostasis (by hyperglycemia, altered oral glucose tolerance, and HOMA-IR) and inflammatory status modulating pro-and anti-inflammatory cytokines (TNF-a, IL-1, and IL-10) and adipokines. Moreover, HPCOO and less extensively WPOO, limited HFD-induced liver oxidative and nitrosative stress and increased hepatic fatty acid oxidation. To study mitochondrial performance, oxidative capacity and energy efficiency were also evaluated in isolated liver mitochondria. HPCOO, but not WPOO, reduced H O release and aconitase activity by decreasing degree of coupling, which plays a major role in the control of mitochondrial reactive oxygen species emission." According to the news reporters, the research concluded: "HPCOO limits HFD-induced insulin resistance, inflammation, and hepatic oxidative stress, preventing nonalcoholic fatty liver disease progression." For more information on this research see: Polyphenol-rich virgin olive oil reduces insulin resistance and liver inflammation and improves mitochondrial dysfunction in high-fat diet fed rats.
In today’s podcast we talk about everything to do with the “emperor of all maladies”, the big C. Myself and Professor Robert have met on a couple of occasions at conferences geared toward healthy lifestyle and cancer, and I could not think of a more educated and enthusiastic person to have on the podcast who is up to date with the evidence and continues to wave the flag for lifestyle medicine and oncology.Professor Robert Thomas is a Consultant Oncologist at Bedford and Addenbrooke’s Hospitals, a clinical teacher at Cambridge University and visiting Professor of Sports and nutritional science at the University of Bedfordshire. He is lead of a Lifestyle and Cancer Research Unit conducting designing and conducting government backed studies evaluating the impact of exercise, diet and natural therapies. More recently, he led the analysis of the 155,000 patient data set (PLCO) which has linked sugar with an increased cancer and tea and broccoli with cancer prevention. In 2019, he wrote the book “Keep Healthy after Cancer”, and remains medical advisor for the lifestyle and cancer website Cancernet.co.uk.We frame our conversation into 3 distinct areas to avoid confusion. What to eat to prevent cancer, during cancer and post cancer with the aim of reducing risk and improving outcomes. As cancer is an extremely broad field and confusing for even medical professionals to understand it’s biology, I want to remind listeners and viewers that this is general information and not to be taken as medical advice. In today’s pod we talk aboutWhat Cancer isThe balance of genetic vs acquired cancer and the influence of lifestyle on riskThe general principles of how to avoid cancerWhat foods to eatHow food exerts a positive impact on cancer riskHow we investigate the anti-cancer impact of foodGut health and cancerThe Warburg effectThe implication of excess sugar on cancer riskWhat to eat during cancerThe potential for ‘prehab’ initiativesVitamin D, Polyphenol and Probiotic supplements, Vitamin SupplementsPost Cancer lifestyle regimens to reduce the risk of recurrenceWhat an anti-cancer diet looks likeThe Future of Oncology: Individualised medicine, Immunotherapy and Metabolic Oncology Check out The Doctor's Kitchen website for all social media links and show notes. See acast.com/privacy for privacy and opt-out information.
A few weeks ago NBT Scientific Director Megan Hall and I met up to discuss the causes of postprandial fatigue, commonly known as “food coma”. We talked about two common causes, both associated with glucose dysregulation. Megan described some of the mechanisms causing hypoglycemia, including accelerated gastric emptying, periods of increased insulin sensitivity, and low hormonal states, while hyperglycemia is often associated with insulin resistance. This was such a big topic we only covered about half of it the first time around, so we’re continuing the conversation today. On this podcast, Megan and I discuss three additional causes of postprandial fatigue: endotoxin, inflammation, and mitochondrial dysfunction. Megan describes each of these scenarios in detail, discussing some of the upstream causes that can be targeted early on to avoid problems. She also provides practical steps you can take if you’re one of the millions dozing off after lunch every day. Be sure to follow along with Megan’s outline for this podcast. Here’s the outline of this interview with Megan Hall: [00:01:42] Previous podcast: Postprandial Fatigue: Is It Normal To Need A Nap After Lunch? [00:03:20] Hans Vink; Hyperglycemia reduces glycocalyx volume while NAC infusion prevents the reduction. Nieuwdorp, Max, et al. "Loss of endothelial glycocalyx during acute hyperglycemia coincides with endothelial dysfunction and coagulation activation in vivo." Diabetes 55.2 (2006): 480-486. [00:03:51] Malcolm Kendrick on the glycocalyx; Podcasts: Why Cholesterol Levels Have No Effect on Cardiovascular Disease (And Things to Think about Instead) and A Statin Nation: Damaging Millions in a Brave New Post-health World. [00:04:51] NBT Strength and Conditioning Coach Zach Moore; Podcast: How to Strength Train Without a Gym. [00:06:21] Postprandial endotoxemia (PPE): definition, causes, downstream effects; Study: Kelly, Caleb J., Sean P. Colgan, and Daniel N. Frank. "Of microbes and meals: the health consequences of dietary endotoxemia." Nutrition in Clinical Practice 27.2 (2012): 215-225. [00:11:04] What to do about PPE. [00:11:56] Probiotics; Podcasts: How to Optimise Your Gut Microbiome and Microbiome Myths and Misconceptions, with Lucy Mailing, PhD; How to Use Probiotics to Improve Your Health, with Jason Hawrelak, PhD. [00:12:10] Megasporebiotic; Study: McFarlin, Brian K., et al. "Oral spore-based probiotic supplementation was associated with reduced incidence of post-prandial dietary endotoxin, triglycerides, and disease risk biomarkers." World Journal of Gastrointestinal Pathophysiology 8.3 (2017): 117. [00:12:36] Chris' sister's story. [00:13:51] S. boulardii - may help with gut barrier function; Study: Terciolo, Chloe, Michel Dapoigny, and Frederic Andre. "Beneficial effects of Saccharomyces boulardii CNCM I-745 on clinical disorders associated with intestinal barrier disruption." Clinical and experimental gastroenterology 12 (2019): 67. [00:14:23] Additional supplements that may help with gut: Enteromend, Permaclear, GI Revive, SBI Protect. [00:17:09] Dietary interventions for PPE. [00:17:14] Plant polyphenols; Studies: 1. Wong, Ximena, et al. "Polyphenol extracts interfere with bacterial lipopolysaccharide in vitro and decrease postprandial endotoxemia in human volunteers." Journal of Functional Foods 26 (2016): 406-417; 2. González‐Sarrías, Antonio, et al. "The endotoxemia marker lipopolysaccharide‐binding protein is reduced in overweight‐obese subjects consuming pomegranate extract by modulating the gut microbiota: A randomized clinical trial." Molecular nutrition & food research 62.11 (2018): 1800160; 3. Kolehmainen, Marjukka, et al. "Bilberries reduce low‐grade inflammation in individuals with features of metabolic syndrome." Molecular nutrition & food research 56.10 (2012): 1501-1510. [00:17:36] Sulforaphane; Studies: 1. Yanaka, Akinori, Junya Sato, and Shun Ohmori. "Sulforaphane protects small intestinal mucosa from aspirin/NSAID-induced injury by enhancing host defense systems against oxidative stress and by inhibiting mucosal invasion of anaerobic enterobacteria." Current pharmaceutical design 19.1 (2013): 157-162. 2. Yanaka, Akinori. "Role of sulforaphane in protection of gastrointestinal tract against H. pylori and NSAID-induced oxidative stress." Current pharmaceutical design 23.27 (2017): 4066-4075. [00:17:53] Hormetea. [00:20:20] Dietary oil composition plays a role in endotoxin transport; Study: Mani, Venkatesh, James H. Hollis, and Nicholas K. Gabler. "Dietary oil composition differentially modulates intestinal endotoxin transport and postprandial endotoxemia." Nutrition & metabolism 10.1 (2013): 6. [00:21:55] Supporting detoxification; Studies: 1. Fox, Eben S., Peter Thomas, and Selwyn A. Broitman. "Hepatic mechanisms for clearance and detoxification of bacterial endotoxins." The journal of nutritional biochemistry 1.12 (1990): 620-628 (SciHub); 2. Munford, Robert S. "Invited review: detoxifying endotoxin: time, place and person." Journal of endotoxin research 11.2 (2005): 69-84. [00:22:20] Enterosgel. [00:24:04] Inflammation; Study: Mo, Zhenzhen, et al. "Endotoxin May Not Be the Major Cause of Postprandial Inflammation in Adults Who Consume a Single High-Fat or Moderately High-Fat Meal." The Journal of Nutrition 150.5 (2020): 1303-1312. [00:25:51] Lucy Mailing on gut barrier integrity: Article: Is a high-fat or ketogenic diet bad for your gut? Discussed on NBT Forum post. [00:26:26] Food sensitivities; Studies: 1. Ohtsuka, Yoshikazu. "Food intolerance and mucosal inflammation." Pediatrics International 57.1 (2015): 22-29; 2. Wilders-Truschnig, M., et al. "IgG antibodies against food antigens are correlated with inflammation and intima media thickness in obese juveniles." Experimental and clinical endocrinology & diabetes 116.4 (2008): 241. [00:27:58] IL-1 and postprandial fatigue; Study: Lehrskov, Louise L., et al. "The role of IL-1 in postprandial fatigue." Molecular metabolism 12 (2018): 107-112. [00:29:05] Mitochondrial dysfunction and glucose dysregulation; Study: Sergi, Domenico, et al. "Mitochondrial (dys) function and insulin resistance: From pathophysiological molecular mechanisms to the impact of diet." Frontiers in physiology 10 (2019): 532. [00:29:54] Normal vs pathological biochemistry. [00:32:53] TCA cycle and electron transport chain. [00:33:21] Insulin resistance is a cellular antioxidant defense mechanism; Study: Hoehn, Kyle L., et al. "Insulin resistance is a cellular antioxidant defense mechanism." Proceedings of the National Academy of Sciences 106.42 (2009): 17787-17792. [00:35:02] Blood sugar dysregulation and mito dysfunction; Studies: 1. Stefano, George B., Sean Challenger, and Richard M. Kream. "Hyperglycemia-associated alterations in cellular signaling and dysregulated mitochondrial bioenergetics in human metabolic disorders." European journal of nutrition 55.8 (2016): 2339-2345; 2. Rolo, Anabela P., and Carlos M. Palmeira. "Diabetes and mitochondrial function: role of hyperglycemia and oxidative stress." Toxicology and applied pharmacology 212.2 (2006): 167-178; 3. Kaikini, Aakruti Arun, et al. "Targeting mitochondrial dysfunction for the treatment of diabetic complications: pharmacological interventions through natural products." Pharmacognosy Reviews 11.22 (2017): 128. [00:36:26] How to support mitochondria. [00:36:46] Low-carb diet; Study: Miller, Vincent J., Frederick A. Villamena, and Jeff S. Volek. "Nutritional ketosis and mitohormesis: potential implications for mitochondrial function and human health." Journal of nutrition and metabolism 2018 (2018). [00:37:04] Exercise; Studies: 1. Oliveira, Ashley N., and David A. Hood. "Exercise is mitochondrial medicine for muscle." Sports Medicine and Health Science 1.1 (2019): 11-18; 2. Memme, Jonathan M., et al. "Exercise and mitochondrial health." The Journal of Physiology (2019); 3. Huertas, Jesus R., et al. "Stay fit, stay young: mitochondria in movement: the role of exercise in the new mitochondrial paradigm." Oxidative Medicine and Cellular Longevity 2019 (2019). [00:37:31] TRE or fasting, CR; Study: Lettieri-Barbato, Daniele, et al. "Time-controlled fasting prevents aging-like mitochondrial changes induced by persistent dietary fat overload in skeletal muscle." PloS one 13.5 (2018): e0195912. [00:38:03] Dietary polyphenols; Studies: 1. Sun, Chongde, et al. "Dietary polyphenols as antidiabetic agents: Advances and opportunities." Food Frontiers 1.1 (2020): 18-44; 2. Teixeira, José, et al. "Dietary polyphenols and mitochondrial function: role in health and disease." Current medicinal chemistry 26.19 (2019): 3376-3406. [00:38:47] Eat berries before a carb rich meal; 1. Törrönen, Riitta, et al. "Berries reduce postprandial insulin responses to wheat and rye breads in healthy women." The Journal of nutrition 143.4 (2013): 430-436; 2. Xiao, Di, et al. "Attenuation of postmeal metabolic indices with red raspberries in individuals at risk for diabetes: A randomized controlled trial." Obesity 27.4 (2019): 542-550. [00:39:34] Eat fatty fish; Studies: Lanza, Ian R., et al. "Influence of fish oil on skeletal muscle mitochondrial energetics and lipid metabolites during high-fat diet." American Journal of Physiology-Endocrinology and Metabolism 304.12 (2013): E1391-E1403; 2. de Oliveira, Marcos Roberto, et al. "Omega-3 polyunsaturated fatty acids and mitochondria, back to the future." Trends in food science & technology 67 (2017): 76-92. [00:39:53] Sleep; Studies: 1. Rodrigues, Nathane Rosa, et al. "Short-term sleep deprivation with exposure to nocturnal light alters mitochondrial bioenergetics in Drosophila." Free Radical Biology and Medicine 120 (2018): 395-406; 2. Schmitt, Karen, et al. "Circadian control of DRP1 activity regulates mitochondrial dynamics and bioenergetics." Cell metabolism 27.3 (2018): 657-666. [00:40:16] Supplements to support mitochondria; Study: Wesselink, E., et al. "Feeding mitochondria: potential role of nutritional components to improve critical illness convalescence." Clinical nutrition 38.3 (2019): 982-995. [00:42:22] Outline for this podcast. [00:42:25] Dr. Josh Turkett’s 4-quadrant model. [00:44:47] 35% of pharmaceuticals cause mito dysfunction; Studies: 1. Meyer, Joel N., and Sherine SL Chan. "Sources, mechanisms, and consequences of chemical-induced mitochondrial toxicity." (2017): 2-4; and 2. Dykens, James A., and Yvonne Will. "The significance of mitochondrial toxicity testing in drug development." Drug discovery today 12.17-18 (2007): 777-785. [00:45:08] Environmental pollutants; Podcast: Environmental Pollutants and the Gut Microbiome, with Jodi Flaws, PhD. [00:45:22] Psychological stress; Podcast: Germline Exposures with Jill Escher. [00:46:35] Support NBT on Patreon. [00:46:51] Book a free 15-minute starter session with one of our coaches.
Dilip Daya is an olive oil Sommelier. Before I met Dilip, I didn't even know that existed! His passion for olive oil, wine, flavors, and food is extraordinary and his knowledge is even more so.When I met Dilip at Olea Oliva, I fell in love with his knowledge and passion for quality, flavor, and people. We were kindred spirits from day 1.If you eat three meals a day and you live to 100, well that's a lot of meals. Enjoy this interview as it will enlighten you to enjoy your meals and all life's experiences with more gusto than ever before. And when you're I the neighborhood visit their gem of a store or online at https://oleaoliva.com/.
Let's be smarter about them! Part 1 of the Defining Dad Bod supplement series - The supplement industry is a multimillion-dollar industry that both poorly regulated and convoluted. Today we dive into the pertinent mindset and understanding necessary to get a handle on the supplements we will cover in this series so that we can truly understand both their utility and function in reaching your goals.From researched quality and quantity to Placebo and Polyphenols this episode will lay solid groundwork by which to understand your supplement program. *Hint - some are worth your money…many are NOTMentionedMore Info On SupplementsDefiningdadbod.com/blog/suppsDo Some Of Your Own Research!examine.comGet More Information About The Upcoming Mastermind!Definingdadbod.com/trufitSave $25 On YOUR JUMPSTARTdefiningdadbod.com/shop/jumpstart(Save $25 with Checkout code: INSTAJULY2020)Join The Inner Circledefiningdadbod.com/innercircleMake A DonationDefiningdadbod.com/donateBecome a supporter of this podcast: https://www.spreaker.com/podcast/faithful-fitness-by-better-daily--5150768/support.
Let's be smarter about them! Part 1 of the Defining Dad Bod supplement series - The supplement industry is a multimillion-dollar industry that both poorly regulated and convoluted. Today we dive into the pertinent mindset and understanding necessary to get a handle on the supplements we will cover in this series so that we can truly understand both their utility and function in reaching your goals.From researched quality and quantity to Placebo and Polyphenols this episode will lay solid groundwork by which to understand your supplement program. *Hint - some are worth your money…many are NOTMentionedMore Info On SupplementsDefiningdadbod.com/blog/suppsDo Some Of Your Own Research!examine.comGet More Information About The Upcoming Mastermind!Definingdadbod.com/trufitSave $25 On YOUR JUMPSTARTdefiningdadbod.com/shop/jumpstart(Save $25 with Checkout code: INSTAJULY2020)Join The Inner Circledefiningdadbod.com/innercircleMake A DonationDefiningdadbod.com/donate
Let's be smarter about them! Part 1 of the Defining Dad Bod supplement series - The supplement industry is a multimillion-dollar industry that both poorly regulated and convoluted. Today we dive into the pertinent mindset and understanding necessary to get a handle on the supplements we will cover in this series so that we can truly understand both their utility and function in reaching your goals.From researched quality and quantity to Placebo and Polyphenols this episode will lay solid groundwork by which to understand your supplement program. *Hint - some are worth your money…many are NOTMentionedMore Info On SupplementsDefiningdadbod.com/blog/suppsDo Some Of Your Own Research!examine.comGet More Information About The Upcoming Mastermind!Definingdadbod.com/trufitSave $25 On YOUR JUMPSTARTdefiningdadbod.com/shop/jumpstart(Save $25 with Checkout code: INSTAJULY2020)Join The Inner Circledefiningdadbod.com/innercircleMake A DonationDefiningdadbod.com/donate
Have you heard the words polyphenols and antioxidants tossed around but not really sure what they mean? Curious about intolerance of plants and how you can correct this from the root cause? Want to know more about how polyphenols support gut health, detoxification and more? Tune in to hear us highlight the power of produce and how you can pack polyphenol rich foods into your diet to optimize your intake and reduce oxidative stress! Polyphenols have demonstrated anti-cancer, anti-oxidant, anti-microbial, and anti-inflammatory properties in human health. In this episode, we highlight the benefits of plants and reasons we find them essential in an optimal diet for whole body health. Learn why organic and sustainable farming increases polyphenol production in plants and what foods have the best bang for their buck (hint: chocolate, wine and coffee make the list!) Also in This Episode: Episode 127: In Defense of Vegetables What are Polyphenols? Benefits of Polyphenols What Creates Oxidative Stress? How Plant Compounds Influence Gut HealthBeat the Bloat Cleanse How Polyphenols Support DetoxUse code DETOXNOW to get the 10 Day Detox Ebook for $1.99 Use code DETOXNOW50 to get the 10 Day Detox Class for 50% off Use code DETOXNOW20 to get 20% off Detox Packs How Organic and Sustainable Farming Increases Polyphenols Abundance Goals for Optimizing Your Intake2-3 cups of leafy greens (spinach is high) Citrus peel Tea 4-5x/wk Berries WineDry Farm Wines What to do if You Don’t Tolerate PlantsDigestaid GI Lining Support The Time and Place for Carnivore Research References in this EpisodeCardona, F., Andres-Lacueva, C., Tulipani, S., Tinahones FJ., Queipo-Ortuno, MI., (2013). Benefits of polyphenols on gut microbiota and implications in human health. J Nutr Biochem, Aug;24(8):1415-22. https://doi.org/10.1016/j.jnutbio.2013.05.001 Marín, L., Miguélez, E. M., Villar, C. J., & Lombó, F. (2015). Bioavailability of dietary polyphenols and gut microbiota metabolism: antimicrobial properties. BioMed research international, 2015, 905215. https://doi.org/10.1155/2015/90521 Ozdal, T., Sela, D. A., Xiao, J., Boyacioglu, D., Chen, F., & Capanoglu, E. (2016). The Reciprocal Interactions between Polyphenols and Gut Microbiota and Effects on Bioaccessibility. Nutrients, 8(2), 78. https://doi.org/10.3390/nu8020078 Pandey KB, Rizvi SI. Plant polyphenols as dietary antioxidants in human health and disease. Oxid Med Cell Longev. 2009;2(5):270‐278. doi:10.4161/oxim.2.5.9498 Hodges RE, Minich DM. Modulation of Metabolic Detoxification Pathways Using Foods and Food-Derived Components: A Scientific Review with Clinical Application. J Nutr Metab. 2015;2015:760689. doi:10.1155/2015/760689 Faller, Ana Luisa & Fialho, Eliane. (2010). Polyphenol content and antioxidant capacity in organic and conventional plant foods. Journal of Food Composition and Analysis - J FOOD COMPOS ANAL. 23. 561-568. 10.1016/j.jfca.2010.01.003 Sponsors for This Episode: This episode is sponsored by Wild Foods, a company that puts quality, sustainability, and health first in all of their products. They have everything from coffee to turmeric to medicinal mushrooms, and every single product is painstakingly sourced from small farms around the globe. They take their mission seriously to fix the broken food system, and believe real food is medicine. They've partnered with us to give you guys an exclusive discount, so use the code ALIMILLERRD for 12% off your order at WildFoods.co!
There is no way to avoid aging. We are all destined to grow old, get sick, and die… Or are we? Although we can’t completely avoid the aging process, we sure can slow it down quite a bit. And disease? Even though it may be the “norm” for an increasing number of older Americans to succumb to chronic diseases as they age, this doesn’t have to be the case for you. There is a new normal when it comes to how we age — and following these six simple steps to reverse aging naturally can help you get there. 6 Ways You Can Help Reverse the Aging Process #1: Take key supplements. Nobel Prize-winning chemist, author, and health advocate Linus Pauling said, “By the proper intakes of vitamins and other nutrients and by following a few other healthful practices from youth or middle age on, you can, I believe, extend your life and years of well-being by twenty-five or even thirty-five years.” He might have added: “And you can live those extra years with excellent and vibrant health!” Supplements (and foods, which we will talk about next) that are best for keeping your body and mind sharp must contain antioxidants. Some essential vitamins to add to your anti-aging arsenal include vitamin C and E as well as Glucosamine and Coenzyme Q10. Polyphenol-rich matcha tea, resveratrol, and collagen are three other supplements that can be age-busters as well. #2: Use the immune-boosting and anti-inflammatory support power of medicinal mushrooms. In addition, if you are serious about your anti-aging regime, you must also consider adding a medicinal mushroom supplement to your daily routine. Have you ever heard of the Japanese island of Okinawa? For generations, the population there was teeming with centenarians (people in their 100s) who were bright eyed and in great physical health. What was their secret? Eating fresh foods, spending lots of time out in nature and in their gardens, and surrounding themselves with family and friends. And, according to research conducted by the Okinawa Centenarian Study, the population also ate a large amount of various kinds of mushrooms, including shiitake and reishi mushrooms. These mushrooms have been proven to have a profound effect on the immune system and help to curb inflammatory responses. The study researchers, as well as many other studies, have linked consuming medicinal mushrooms with relief from inflammatory disease, osteo- and rheumatoid arthritis, autoimmune disorders and digestive problems, just to name a few. #3: Eat Antioxidant Rich, Anti-Aging Foods. Besides mushrooms (which can be consumed in tea, in food form, or as a supplement), fill your plate with foods that are rich in omega-3 fats such as wild caught salmon, green leafy organic vegetables that contain high numbers of phytonutrients, berries such as raspberries and blueberries that have antioxidants called anthocyanins (which have been shown to slow tumor growth as well), and healing herbs like turmeric, basil, and ginger. Want to improve your odds of living longer and living pain-free? Make it a point to also avoid all processed and GMO foods (including GMO produce), refined sugar, wheat products (especially commercially-produced breads, pastas, and baked goods), trans fats and artificial ingredients, and keep alcohol consumption to a minimum. The best diet for staying vibrant into your 70s, 80s, and beyond is the simplest kind of diet. Eat real, recognizable food and plenty of (preferably raw or lightly steamed) vegetables in a relaxed setting and drink plenty of clean, filtered water. Even when we are older, our bodies are still primarily made of water so the key is to hydrate, hydrate, hydrate! #4: Get Plenty of Sleep. Older people often have trouble sleeping, especially women in their post-menopausal years. The reasons for this are plentiful: stress and anxiety as well as hormonal imbalances can play a part. Making rest a priority can do wonders for your daily energy levels and clarity of mind. Studies have shown that individuals with sleep disorders such as “sleep apnea” and insomnia have an increased risk of cancer. Insufficient sleep has been associated with cell damage, neurological impairment, a compromised immune system, inflammation, and accelerated aging. When you get consistent, quality sleep, however, these conditions can sometimes reverse as the body is allowed to repair and restore during sleep. #5: Exercise Your Mind. You may think of activities such as doing crosswords or sudoku, learning a language or musical instrument or reading a book as ways that you can keep your mind active in later years. But these activities are just the tip of the iceberg when it comes to how you can boost your brain power. Stress-relieving and focusing activities such as meditation (and movement meditations like qi gong and forest bathing) have been proven to improve the strength and length of telomeres, stretches of DNA at the end of chromosomes which protect our genes. Telomeres keep chromosomes from fraying and clumping. Shortened telomeres are associated with aging as well as cancer and higher risk of death. A 2015 Canadian study linked evidence of longer telomere strands to meditation (when compared to those who did not meditate). In addition, activities like creative visualization, repeating affirmations, and doing something like Emotional Freedom Technique (which also clears energy channels for physical healing, according to the principles of Chinese medicine) can keep you in a positive state of mind which can aid in the slowing down of the aging process. Famed actress Sophia Lauren had it right when she said, “There is a fountain of youth: it is your mind, your talents, the creativity you bring to your life and the lives of people you love. When you learn to tap this source, you will truly have defeated age.” #6: Keep Moving! Hundreds of studies have correlated even moderate amounts of exercise with lower blood pressure, lower incidents of diabetes, lower cancer rates (sometimes up to 80 percent reduction), lower rates of heart disease, increased longevity and happiness overall. Take a walk (especially in nature), swim, do some yoga or tai chi, or dance to your favorite tune. The most important thing is that you move your body at least 3 to 4 times a week for at least 30 minutes, according to experts. In addition, if your lifestyle or profession dictates that you sit for long periods of time, make sure that you get up to stretch and move every hour at least. Your Reverse Aging “Recipe” Taking key supplements (including mushrooms for supporting your immune system), eating healthy, organic foods and drinking fresh, filtered water, getting plenty of sleep, exercising the mind, and moving the body regularly. These six actions really are the “recipe” for not only a long life, but a vibrant one as well. Slowing down the aging process and staying sharp into your hundreds like the centenarians of Okinawa is possible. It simply takes discipline and a vision of a strong and healthy you, no matter what your physical age!
There is no way to avoid aging. We are all destined to grow old, get sick, and die… Or are we? Although we can’t completely avoid the aging process, we sure can slow it down quite a bit. And disease? Even though it may be the “norm” for an increasing number of older Americans to succumb to chronic diseases as they age, this doesn’t have to be the case for you. There is a new normal when it comes to how we age — and following these six simple steps to reverse aging naturally can help you get there. 6 Ways You Can Help Reverse the Aging Process #1: Take key supplements. Nobel Prize-winning chemist, author, and health advocate Linus Pauling said, “By the proper intakes of vitamins and other nutrients and by following a few other healthful practices from youth or middle age on, you can, I believe, extend your life and years of well-being by twenty-five or even thirty-five years.” He might have added: “And you can live those extra years with excellent and vibrant health!” Supplements (and foods, which we will talk about next) that are best for keeping your body and mind sharp must contain antioxidants. Some essential vitamins to add to your anti-aging arsenal include vitamin C and E as well as Glucosamine and Coenzyme Q10. Polyphenol-rich matcha tea, resveratrol, and collagen are three other supplements that can be age-busters as well. #2: Use the immune-boosting and anti-inflammatory support power of medicinal mushrooms. In addition, if you are serious about your anti-aging regime, you must also consider adding a medicinal mushroom supplement to your daily routine. Have you ever heard of the Japanese island of Okinawa? For generations, the population there was teeming with centenarians (people in their 100s) who were bright eyed and in great physical health. What was their secret? Eating fresh foods, spending lots of time out in nature and in their gardens, and surrounding themselves with family and friends. And, according to research conducted by the Okinawa Centenarian Study, the population also ate a large amount of various kinds of mushrooms, including shiitake and reishi mushrooms. These mushrooms have been proven to have a profound effect on the immune system and help to curb inflammatory responses. The study researchers, as well as many other studies, have linked consuming medicinal mushrooms with relief from inflammatory disease, osteo- and rheumatoid arthritis, autoimmune disorders and digestive problems, just to name a few. #3: Eat Antioxidant Rich, Anti-Aging Foods. Besides mushrooms (which can be consumed in tea, in food form, or as a supplement), fill your plate with foods that are rich in omega-3 fats such as wild caught salmon, green leafy organic vegetables that contain high numbers of phytonutrients, berries such as raspberries and blueberries that have antioxidants called anthocyanins (which have been shown to slow tumor growth as well), and healing herbs like turmeric, basil, and ginger. Want to improve your odds of living longer and living pain-free? Make it a point to also avoid all processed and GMO foods (including GMO produce), refined sugar, wheat products (especially commercially-produced breads, pastas, and baked goods), trans fats and artificial ingredients, and keep alcohol consumption to a minimum. The best diet for staying vibrant into your 70s, 80s, and beyond is the simplest kind of diet. Eat real, recognizable food and plenty of (preferably raw or lightly steamed) vegetables in a relaxed setting and drink plenty of clean, filtered water. Even when we are older, our bodies are still primarily made of water so the key is to hydrate, hydrate, hydrate! #4: Get Plenty of Sleep. Older people often have trouble sleeping, especially women in their post-menopausal years. The reasons for this are plentiful: stress and anxiety as well as hormonal imbalances can play a part. Making rest a priority can do wonders for your daily energy levels and clarity of mind. Studies have shown that individuals with sleep disorders such as “sleep apnea” and insomnia have an increased risk of cancer. Insufficient sleep has been associated with cell damage, neurological impairment, a compromised immune system, inflammation, and accelerated aging. When you get consistent, quality sleep, however, these conditions can sometimes reverse as the body is allowed to repair and restore during sleep. #5: Exercise Your Mind. You may think of activities such as doing crosswords or sudoku, learning a language or musical instrument or reading a book as ways that you can keep your mind active in later years. But these activities are just the tip of the iceberg when it comes to how you can boost your brain power. Stress-relieving and focusing activities such as meditation (and movement meditations like qi gong and forest bathing) have been proven to improve the strength and length of telomeres, stretches of DNA at the end of chromosomes which protect our genes. Telomeres keep chromosomes from fraying and clumping. Shortened telomeres are associated with aging as well as cancer and higher risk of death. A 2015 Canadian study linked evidence of longer telomere strands to meditation (when compared to those who did not meditate). In addition, activities like creative visualization, repeating affirmations, and doing something like Emotional Freedom Technique (which also clears energy channels for physical healing, according to the principles of Chinese medicine) can keep you in a positive state of mind which can aid in the slowing down of the aging process. Famed actress Sophia Lauren had it right when she said, “There is a fountain of youth: it is your mind, your talents, the creativity you bring to your life and the lives of people you love. When you learn to tap this source, you will truly have defeated age.” #6: Keep Moving! Hundreds of studies have correlated even moderate amounts of exercise with lower blood pressure, lower incidents of diabetes, lower cancer rates (sometimes up to 80 percent reduction), lower rates of heart disease, increased longevity and happiness overall. Take a walk (especially in nature), swim, do some yoga or tai chi, or dance to your favorite tune. The most important thing is that you move your body at least 3 to 4 times a week for at least 30 minutes, according to experts. In addition, if your lifestyle or profession dictates that you sit for long periods of time, make sure that you get up to stretch and move every hour at least. Your Reverse Aging “Recipe” Taking key supplements (including mushrooms for supporting your immune system), eating healthy, organic foods and drinking fresh, filtered water, getting plenty of sleep, exercising the mind, and moving the body regularly. These six actions really are the “recipe” for not only a long life, but a vibrant one as well. Slowing down the aging process and staying sharp into your hundreds like the centenarians of Okinawa is possible. It simply takes discipline and a vision of a strong and healthy you, no matter what your physical age!
In this episode of Straight Up Wellness, Kate talks with Fitness Nutrition Specialist and Personal Trainer Jessica Ederer about the healing benefits of Pique Tea crystals. The post 091: Jessica Ederer on The Polyphenol Advantage of Tea appeared first on Straight-Up Wellness.
Studies have revealed conflicting results regarding the risk of cancer from alcohol consumption. Furthermore, some studies have suggested that wine may have benefits that separate it from other alcoholic beverages. As wine contains a significant amount of chemicals, specifically polyphenols like anthocyanins and proanthocyanidins (PA), that can affect cellular function and promote health, this hypothesis is reasonably supported by recent research. Polyphenols promote several anticancer cellular pathways, including xenobiotic metabolism, support of innate antioxidant production, and stimulation of phase I and II detoxification of carcinogens. However, the multitude of growing and production conditions of grapes, including temperature, water availability, soil type, maceration, and aging can result in a remarkably varying final product based on the available literature. Thus, we hypothesize that wines produced from grapes cultivated between steady daily temperatures at 15–25°C with moderate sun exposure from flowering to harvest, lower vine-water status, resulting either from lower precipitation, and irrigation practices or more permeable soil types, limitation of fertilizers, extended maceration, and aging in oak will impact the concentration of anthocyanins and PA in the finished wine and may have a differential impact on cancer. This higher concentration of polyphenols would, in theory, create a healthier wine, thus explaining the conflicting reports on the benefits or harms of wine. Champ CE, Kundu-Champ A. Maximizing Polyphenol Content to Uncork the Relationship Between Wine and Cancer. Front Nutr. 2019;6:44. Published 2019 Apr 30. doi:10.3389/fnut.2019.00044 This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Sections of the Abstract, Introduction, and Conclusion are presented in the Podcast. Access the full-text article here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502998/
Ken & Eric tackle the outlying topics, nice GCP show contest, learn about NBS (Narcotic Bowel Syndrome), selfies are killing people, PTSD and med marijuana in Texas... Drop in the GCP and enjoy DR. Brown addressing the topics that could be shaping the world around you.https://lovemytummy.com/spoonyhttps://gutcheckproject.comNancy husband and wife may kiss the bride connectivity care whenever you need video chatting with the doctor right from your phone so I don't need stitches thank you Dr. United healthcare health plan benefits may vary welcome to the projects with your host Dr. Ken Brown I Eric Rieger will we all check our egos at the door and nothing is off the table again what happened man we are on episode number 12 we are big doesn't it is a big dozen so it's always like this on this is like a recap episode were just going to cover a lot of stuff just you and I and really really really cool like this is super exciting so on we call this episode topic talk simply because next week we actually will be out of town to go to IFN down in San Antonio the functional medicine Society corrected outwardly running the booth there outfront you there and I FM in San Antonio I love San Antonio it's a great city absolutely and it's kinda wild so if you never heard of IFN we have tried for this is our third year it's so popular but even though we were asked by the IFN to go ahead and be a part of the show we just wait we can sign up in time they heavily that everyone is going to be a part of the show they wanted John Teal in this year now they've moved venues to a larger one John Teal was definitely invited were really really excited to be there on behalf of trying to heal so looking forward to the show next week on how the Antonia I love the functional medicine doctors because they are open to just talk about checking your ego at the door they will at least listen to anything at all prior episodes episode number 12 we covered a lot of things that could be considered a little bit atypical you know the photo bio modulation things CBD talked to were always doing all that kind of stuff himself stem cells that stuff is novel and it's the functional medicine community it typically leads the way and they start using it and then we can start getting some data and then we can start putting into traditional medicine definitely so today's today show we decided we would kind of reset we got a great contest to remind everybody about we've got does some some viewer emails that have suggested some incredible topics to one of their particular from the believe it's leaves David and I were going to get to that in a moment but can a reset of course to begin speaking about trying to heal if you ever suffer from bloating or abdominal discomfort get yourself your daily polyphenols with all trying to heal go to love my tummy.com/spoony love my tummy.com/20 why/spoony can muddy think would say that because it makes everybody a winner when you put in the code spooning you out of the vision rolled into our discount contest in your hundred percent guaranteed to get a huge savings on this so SPO and why putting codes booty definitely so love my tummy.com/spoony spoony so the network continues to grow the popularity continues to grow I checked out trays chow down again just as last week I'm a terrible cook you know this I'm getting a a nice girl sets a big green egg yeah green egg having him come in the worst on the grill but now I follow directions I can actually what makes food the people will eat not just the menagerie of animals that is charred remains and I you know is less easily but no it's is a lot of fun but Trey shot out is got great information check them out on the spinning networks money.com has a full lineup of his ally would be all the times that I realize there are a lot of people who catch the repeat go to spoony.com and you can see for all of the shows but definitely trays chow down where it finishes and where it re-airs throughout the week awesome the one of things only try with you okay right now just I realize I think one of the things we should do is continue to grow intellectually okay you know that I like to read the daily stoic every day they always have quotes from scholars Jeff Solomon read you a quote but I want you to tell me which scholars said this okay this sounds hard yes it's gonna be really difficult okay I am probably in the sky flying with the fish or maybe in the ocean swimming with the pigeons see my world is different I'll give you a hint okay who loves lasagna oh is this this is God belittling this little why I should've known that now yeah yeah I know that's good he had a real Jesus movement sounds like lasagna I got in real Jesus move in silence like lasagna yeah man I got as deep on lyrics sure that's funny so what do you what you are going on as best we can mass past weekend was the beer I have a stuff like essay on repeat but where were back into into basketball and hip so that a couple times I have said that 12 times the exact I know no doubt and debit actually this last Sunday because of basketball the boys missed they miss their traditional celebration with with mom so Marie and the boys went drove I went drove vast electric go carts which we are introduced to backhaul crewmen knock her out in California I think you may miss that woman I want to go with them in thesis racetrack called K-1 and I have one now here in Dallas and that means great they loved it K-1 the one that so I did one when I was it I was given a lecture at ECG I went to the morrow and ready one and it's it's basically a tract that has light turns that little beat dips up the down it's not just a straight flat what was this one that is deathly not flat but I don't think it has any bridge volley or anything else I can think it's all routine S-curve about it but it is deftly technical and of course the boys and Marie came back and they send in one's great number to their surprise at the max speed limit is 45 and Max said my youngest he said that's scary scary dad but nope I really want to be out jet when you were almost tight turns like that oh yeah yeah for sure so the great Mother's Day no not typical but really not typical she liked do I do things are adventurous so that was that it was deathly fun for them speaking of carts do you remember when our good friend Russ ironic Dr. Veronica San Antonio which were to be seen next week sure he called into the show when we were talking about Lou Gehrig's disease and you know the effect is that dying of that right one of his good friends their son was a go Carter like always the child became really good when on the circuit and now like races for Porsche no way is like a 18 or something cool scratches will tell Mac to stick with it just seemed it seems so hard and I know it's it's a career pathway that I'm completely ignorant to I don't know how they how they get to that point where was someone said when I want you to drive for my team even though I'm pouring millions of dollars in this car in for a crew and equipment etc. that just seems it seems while was not sunny like okay you look it's you wonder how people end up in certain sports like for instance Tim Duncan was when he was a swimmer yeah you know if Michael Phelps didn't jump into the pool what would you be doing in certain countries they certainly communist countries were back in the day when they would find Olympic athletes they would like looked like you you're to be a power lifter based on X, Y, and Z user to do this I don't know yet so that give you a Tim Duncan is doing now no I believe that he has been training as an MMA fighter post-NBA career no way I yeah I'm certain I read that somewhere but yet that's that's what he spends his time doing is its MMA training etc. mean so from awesome swimmer if I remember correctly story about Tim Duncan I don't think that he I think that he really played competitive basketball until was a very late team and then went on to and he and Junior hide in play and then he did start planes like his junior senior high school maybe I do it one time I don't member the whole sword hung up as I was we lived in San Antonio I saw San Antonio and I had the David Robinson and Tim Duncan team and they were just an incredible team to watch so focused individual for sure how you know what I did not tell you crazy story so you knew I was in San Antonio two weeks ago the family okay I taste funny story sup with a family and we use over and lift whenever we go on vacation it just it just takes away the anxiety of having to wonder where you can go and even though you may be familiar with and it was a town just is easier nobody can hop in a you joy your conversation you go out to eat happen to a new girl after something some kind of rideshare something like that well after one of the games we often do one of these ride shares and were going back to our hotel which is down in downtown San Antonio which is going through a great renovation of of Regent application and it didn't do a lot clean up I mean there's cities do that they Evan flow and San Antonio is kind of on the uptake right now so it is starting to really kinda come together but we stayed at this new hotel that just open nothing months ago and were making our way down the road and the traffic jam begins to kind of near Jack is bottlenecking because there's construction and we see seal vacationers tourists like to know what they are what parts on a cousin over in downtown will probably like Riverwalk area area now, probably like two blocks away from Riverwalk itself where where we are on the car but you can see tourists making their way to the Riverwalk area and I believe our hotel backed up to it so about 2 1/2 three blocks away from our hotel's hotels nice really nice well so on one side you see tourist making away on the other side you see where the the economic developer has a quite started but it looks like to get some preparations forward to redoing the road and there's just a group of just random folks I'm okay and one gentleman grabbed my attention because he stood out and is wearing on the tour side are only not on the terrace okay he looked like he knew where he was but not everyone else really knew if he knew where he was whole and he had a tie-dye shirt on and it was his kind dirtying in and tatted me up that happens on our tattered tatted but that tattered and I hit on some camo shorts and lots of keys like EEE can probably open up most of the doors and Senate just like on the changes this is a big ring and a Dave they look very noisy I can tell of it was that was an alert bell that he made for himself or he really had access to lots and lots of places but since we this gigantic ring of keys and he's kind of looking at some of the key master from the court or Ghostbusters it doesn't really matter and at this point he's looking it away and were stopped in traffic which is bottlenecked as a red light and he's, looking closely cars and then kind of checking them out now and I'm still not thinking too much of it but I did I just noticed you like holding keys up to I think this will work to put my name in there now it it it what wasn't quite like that but then suddenly he just decides to make his way in there's just these two trash cans there's a black one as a blue and but that they are identical and in shape and whatnot but it's the big metal was a kind bow out there there meant to be on the sidewalk easy for passage and you throw garbage and it will he walks past the black one with intent and then dips his head down into the blue which was the second with complete intent and he's only in there for half a second because he reaches in and he grab something right away so he it appears to me he knows this is in there and is he brings it up he's holding a handle and he's basically shaking off will looks like trash can juicer trash can do what I want to it's it's it's a really really rare fruit but and in most urban settings you'll find this this trashcan fruit in you and then you can squeeze the juice yes you can always squeeze the trashcan or as later my my my family decide that I think that's just blood because what it will hence was a no go was a hammer it was about 18 inches long and then he picks it up and looks at it turns it from side to side glances that all of the cars and then sets the hammer down and put his hands on his hips and so the key master of San Antonio yes nothing happened was trash Nancy standing there and then all of a sudden he just bypasses and realizes that he remembered where he left that hammer he said I guess he was in the marinating and I'm not really sure what was going on but it was read it was really interesting because then I found myself feeling like a fish in a fishbowl I we hopped out I don't know what we do and why is he looking at our car was he looking at the other cars what to do with those keys once you hammer how do you know is in there what's that juice so anyway I just I found myself wondering what puts someone in that situation but he had he had no conversation with anyone around it is probably 5 to 10 people walking passing by and then is he just kind of zoning out scanning vehicles watching them bottleneck he just decided well it's time on going to go ahead and pulled his hammer out and he didn't go and do anything with it he just stared at cars every set it down and then kept staring at the hammer and then staring at cars and then finally we moved hello you guys in traffic I saw is bottlenecked seriously in any way we we've gone from two lanes down to one but finally the light turned green and slowly we made our way and have I was happy-seemed like a bully expecting Russ to call in again like this will go much so here in San Antonio you know hammering like little back story here because words do filled in that or just maybe he's looking for a second nails I don't know he's looking for something it's given given the door to open given some construction project to do he's ready he's ready to build really quick that it's funny that you brought the goober live thing because on the news this morning they were talking about how certain industries just disrupt everything what we know that with completely disrupted the whole transportation sure catches whatever everything well because of the Over and lift drivers now in certain airports will do this in certain places this whole article came out about how at the Washington airport I think with the Reagan airport Washington broom lift drivers would get together and they would all turn off their apps for two minutes and what that would do is in the algorithm of bring with okay it would show that there is a lack of drivers in that area and increase the fair yeah so they were genius they would all do it together at the same time so that they could increase their fares you know how it says oh fair increased high-volume time it's a really highborn time that you have a lack of drive right and so they all get together it's technically illegal in the Buber and lift driver handbook handshake whatever it is the cheater there been other things that happened in Newbern lifts the would that be considered price-fixing I'm here 100% is considered price-fixing that means what would it be on the action of the other drivers are doing I'm just curious because their action at the one putting in the algorithm for the fair increase it's technically over and lift or any of the others who are doing that they are there calculating it by their scarcity so these drivers are just on their there free to turn their phones on and off the other actually saying that what the will do that but here's the here's the quote every night several times a night to relive drivers at Reagan National Airport simultaneously turn off the rideshare apps for a minute or two to trick the app into thinking that there are no drivers available creating a price search when the fair gets high enough they all agree it's time and they turn it back on so they probably are just sitting there searching to see what the cost is everybody sit there waiting and it's like old hold go to Braveheart and that's nice now that's really interesting but I mean if you think about it I mean that's that's the access that's it's the loop all right that's what everyone does they find loopholes they find it the path of least resistance there thereafter to make money I mean that's some of them that's that's their job that's just but it drives me nuts because I mean you know I've been to let conventions like that like natural Expo West or when thousands of people suddenly walked out of the building with some massive conference and you go to that group or a new light the fair just quadrupled oh yeah just coming that's nuts we've been that even the Lubbock and so I've gone out there to either sport and I met the one driver low but by the way the wind so I I've been out there for for game day now for it to take the ball game or even basketball and when it's not you want to take an Uber you can go from one side of town to the other it's very easy drive people drive friendly at their it's super super easy is never congested you can make one side of the other in about 10 minutes no matter where you are there may be $10 at most but on game day you can easily see it going just from being at the campus which is around the 4th to 19th area and then head over to 50th you may see the fair as much is 35 bucks just to get your going to meet people for for dinner whatever after a game but yeah that's I always wondered that because it's not it's done at the hard to hail the Uber why the fair increases it silly just because you can because that's really what it is why think I think it all comes down to that I think the algorithm sure that is basically there's a load a need or the drivers are being used up the fair will increase I think is to incentivize other drivers that are on break or whatever to down and out to get out and do that and I don't know I've never lived under the rug she had friends who been in between jobs and it's been it's been great for them to be able to supplement income is really some I don't know do do Cooper drivers airlift drivers get like in an alert that taxpayers are increasing they wanted turn your the cab I don't owe very much like John Wick with the assassins when the yeah they tell about the alert's time it's time to go back in business and help in my car so what what is happening in the Brown household at the moment well we got kind of proud of Lucas tonight he is being inducted into the national honor Society who is nice this is interesting right over here in Colleyville which means I don't have to go to farm and hang out here just work here in this lovely Fort Worth area no joke what I meant drag a five minute drive yeah it's nice for you Lloyd is complaining that it's at 5 o'clock in Colleyville and like to meet you there it's so proud little guy doing the title of the Internet and, she's she's been Judy named Shiva name to the list man so the school this public school the school that Carly goes to has some really smart kids and it is very proud of Carla she got always wish of this presidential award right and they gave always other awards and this is it the school goes up to the eighth grade and one of the awards that they gave was the when Duke invites kids to take the SAT tips five tips are some general but it's the real SAG that I get in there put the same pools although the high schoolers they had at the school seventh and eighth graders they had like 12 of a score over the 95th percentile 95th percentile compared to high school senior US why probably US white while yeah that's why I'm so proud of of my daughter for you and straight A's in school that is academically extremely competitive wow well that's that's just a curiosity so I your and your oldest Lucas he's been doing home so now for this last year so that he could do the touring that he needs to do for tennis house that has a working out for him both working out that's why were doing this over here it's actually considered great by public school but does everything online) it's just because of his schedule it's just one of those things you can't miss is what schools he doesn't so great I call it was actually pretty well known throughout Texas for their curriculums that's really interesting they seem really innovative account on top of it it's a little so far it's worked really well in ways they don't like it and that's also siding the usual stuff so I think next year when he goes to high school he's going to try and integrate himself a little bit with some of the extracurricular type stuff but there's something that will and in that makes sense though so he can be he would be involved kind in the club activities of people his own peers and have some more social interaction but it's not like you didn't have any this last year he's got on me I hear you bring it the same names over and over again that is a tennis cohort said he sees on the road Weatherby from the West Coast or down to Florida he just sees them sets kind of his colleagues the moment it's pretty much the colleagues I mean everybody get out to some of the basketball menu guys do is run these different circles and sure you know you just end up becoming friends the parents become friends know the boys liked (different ages notes it's the beauty of life just can't get yourself exposed to get out there little bit speak of exposed your boys are not should say speaking of exposure that's all that is all right yeah well I was always dance up that I had a great time seeing your family at generosity feeds once told him about the man Ronco blending while huge contact that we met out at dead baby bathwater and note big shout out to Hollis Mladic for knowing exactly who to who would include net group so ill for the listeners Dr. Brown here is he doesn't say to himself as one of the most altruistic people without ever saying it and basically we took the company they were starting here we have that I don't have the sick as I have it tattooed on my lower back but debit for the CBD and the research and are trying to heal we always want to find the best avenues to give back to the public and sometimes weekly letter window when we do it sometimes we don't but this last week it was really cool we get to talk about a little bit because it took a lot of pictures and his generosity feeds and Rocco Bundy with mod pizza they go to a lot of different urban areas I think almost every weekend and they recruit people to come in and pack meals in this last Saturday it was Saturday Saturday yeah we we packed 11,000 meals for needy children in 44 minutes 44 minutes in the DFW area what something I did not know is that one in five kids the only food that they get is actually at school in certain in certain urban areas because of the the lunch program that's the only meal that they get so that they may go the whole weekend without food that's what this is for us to stick food in their backpacks so that they can eat there was a really cool thing and actually when I was even also equally impressed with was the quality of the ingredients they were pulling out to make those suits that were on the go that it wasn't just beans and it wasn't just beef it was high quality beef broth Max etc. they they want to feed the kids a nutritious meal when not to say hello a look we give them some rice the complex Caritas like that you have the protein you've got a the rule base for the libido fat that's awesome was I totally agree and pack and that those you are doing doing charity like that once in a while just remind you that there there are people out there that are quiet but they may not be getting the the basic needs of life that it was it was a lot of fun Ron thank you so much for the invitation and of course he's he's been a great template on showing us what we can do to engage in more charity getting back with the companies and we we plan to take full opportunity to do so that was a quick half-hour next time I will already already get into a research topic in the next half-hour we had a talk about the dangers of selfies really interesting statistics there had what's going on that you in developed countries not building see here a little bit so 12 I have thousands of aspiring authors teamed up with Christian faith publishing to publish their blog because Christian faith publishing is an author friendly publisher who understands that your labor is more than just a book we provide authors freedom and flexibility throughout the publishing process professional book editing award-winning design and some of the highest royalty structures in the publishing industry and is always you will retain 100% of the rights to your book I was looking to find a company that I could trust one that assisted in the editing process completely Christian trade publishing will publish market and sell your books in all major bookstores and online booksellers as well especially Christian bookstores call for your free author submission kit 800-978-4812 800-978-4812 800-978-4812 that's 800-978-4812 Dr. come around here a host of project with my cohost Eric Rieger I've seen in my practice that I'm trying to is a whole lot more than just the bloating product yes it is a whole lot more than just exploding because of the polyphenols that you find in Alicante what is looking to these polyphenols beware these polyphenols help you have more energy and polyphenols are great sounds like it's good health: more people than just loading go to love my family.com/take the pain out of ordering your diabetic testing supplies with diet thrive diatribe ships the testing supplies you need directly to you when you need them best of all with plans starting as low as eight dollars a month diatribe is probably going to cost you less than what you're paying today diatribe is so convinced that you love their service they're offering your first month of supplies three simply type the Kodak DOC and checkout diet Thrive.com that's DIA Thrive.com okay that is now the second half hour at episode 12 that check project is reminding your break I completely forgot to hit on something that was important even said I was going to do it the top of the last half hour and forgot so what was tests I now when I forget probably because I'm not training radio so you do a lot of things were not trained definitely heavily do so gut check project we want to reward the listeners and we already had people who have responded heavenly appreciated everyone so far has sent me examples of doing this through iTunes and that's great so keep that up but essentially the contest to win a free month supply of Voltron teal and a free KB MD CBD flavor of your choice whether it be natural or sentiment is simply have to go to you YouTube or iTunes or really both and then subscribe take a screenshot send me an email which all you have to do is go to get your project.com go to connect you'll see on there you can select the message it says I subscribe and it says it's a message it in July we will draw a winner we have five winners that's the value of how much I watch it.can of all of that yeah that's well over hundred bucks right that's well over 100 bucks so at south 300 bucks and you pay shipping we will get it to you so simply go to iTunes search for gut check project subscribe share tell your friends about it so they can enter also or inner for them anyway have used to do it and then take a screenshot shoot me an email whenever we contact you when you when you supplant social screenshots and you get and then do the same thing at YouTube and you can enter again so also is there all were already giving back is not even our chairs so if you want to guarantee that you're going to win the contest was an easy way to do guarantee that you and I went guaranty what you want to be guaranteed to win you just go to love my tummy.com/stony everyone's a winner at that look everyone's aware that location putting code smoothly and Juergen with a huge discount you to save money right there your home your phone for you looking at what I'm laughing because remember okay the top of the hour I said I want to be more intellectual with you which scholars said I'm probably in the sky fly with the fish or maybe in the ocean swimming with the pigeons Jesse my world is different I give you a hint that I said has something to do with lasagna will my wife Loida just texted me and she said with that I thought it was Garfield legal scholar Garfield right you actually probably on equal footing just in two different ways I got the logical thing to say he did a political basis is a lazy cat what you think about that is that is AAA really really lazy cat that made his own cartoon no being that lazy is pretty successful towards Casca but you know you're not lazy I know you have a research topic that you want to get to I do want to get to that but first I want there's some cool stuff that's happened in the news recently I was forwarded an email that House Bill 3703 in Austin patients will now be able to have access to the states medical marijuana program if they been diagnosed with medical seizures multiple sclerosis terminal cancer incurable Alzheimer's Parkinson's Huntington's autism and Lou Gehrig's disease and we we often talk about Alzheimer's Lou Gehrig's disease and autism we talked about that a lot so this is this bill did pass in Austin yesterday I think is what passed those pretty one thing the people were little upset about is that they did not allow PTSD which is honestly very very common but PTSD know that is interesting do you think that what number one the exclusion of it it just this is a unique to the medical field either legislators are elected to make these decisions don't you think it's kind of strange though that probably there's a lack of expert opinion in helping shape things and applied to someone who would have the knowledge to do that you got elected person who has any idea what their background is in essentially they are the ones determining what the best sciences to make a decision for who can have access to something so I had a patient that is a patent attorney and there's some patent laws that her changing and she got together with a bunch of other patent attorneys and other offices and they got hold of the senator into I think I would get this wrong but basically to have a lunch with him to explain why the bill that's presented is not a good one and it will lead to patent issues Robert has a little date they hide stuff and that it cost like $50,000 to have lunch with oh my educate go to okay yeah but I mean what is the money go to the coast to the campaign or to go through whatever but the whole point is is who gets to the person that makes the vote just as make sense it's that's tough and you know the whole PTSD thing that's what my actual article is on but it's it's pretty thick it's pretty cool to get into that but there's a reason why I really do think that we need other treatments for these diseases that right now in the medical field we don't have good treatment for and people are self-medicating all over the place onto a quick story before you get that research his adjuster mommy and I did not share this with you this last week but you know that I do I blocks for another friend of mine now ophthalmologist Dr. Rogers Eckhart fantastic out the mobs by way of indenting so we had a patient who came in older German served Vietnam service country proudly he's basically been relegated to the VA for his his healthcare to get chronic pain my pain issues this particular patient did and he came in with some bad pain so he couldn't get under control and the person overseeing his care at the VA has determined now that he will not refill the OxyContin or wherever he was on I can't protect which one it was a HUD known size hardcode on hydrocodone that he was currently on he's not getting any more because they felt like it it it kept increasing hey base was getting diminishing returns they just are stopping it for a while will basically what that did is it allowed his blood pressure to increase to Heinz where we could do the procedure so this poor man it is relying on the VA etc. he begins to pour his heart out to me says I've gone to the VA I tell them I am in pain and they're telling me that all I'm trying to do is raise the dose I have no interest in quota quote being high or anything else like that and then he went on to tell me something did just Kelly shattered and shatter me when I hear you talk about the marijuana lawn it's great that they're opening up access but he went on to tell me that 3 1/2 years ago he had gone out of state to Colorado with his family and was able to obtain marijuana legally in Colorado and that his pain threat or is is obtained for the threshold I guess technically in his in his description, went up the threshold went up and the pain went down any had great comfort he was able to sleep for the first time and will able to go to the bathroom without issues and so when I hear that and he returns here and he said he was then worn by the VA when he began to talk to his doctor about it if he were to test positive he may be kicked out of the availability to get his hydrocodone here while he still in Texas it just what what kind of service are we allowing these people to get this poor man now he couldn't get his it will be good to scatter so I mean if you stop and think about that this is the problem when I went to medical school we were told you can you have to know one of the five things you have to make sure that you take care of it's a vital sign pain is now vital sign I what is your pain level if you're if you have somebody was in pain you are obligated to treat that paint and we were told that don't worry you can get people Vicodin all this other stuff because is always a real pain there will be no addiction issues that is not true not true at all we learn that one like right now were still learning it that's also excited to see that Denver at least decriminalize the use of soul Sieben yeah because there are trials going on right now silicide is extremely effective in PTSD and you and I had a long talk with Dennis McKenna right and that psilocybin is the actual molecule bits and mushrooms the people described as mushrooms the hallucinogenic mushroom but that civil Sieben really does some interesting neurologic stuff and somebody was a huge part of that is Joe Rogan Brian I was listening to item number which one it was Joe Rogan was on and that they kept talking about doing suicide and in various doses and how micro-dosing is actually something that a lot of people are doing a lot of very successful CEOs are doing so it was with Jorge my hospital is an MMA fighter name in MMA fighter they were talking about where Jorge did some bro science it took a little too much mushrooms is pretty funny episode but I always get back to this we we create this problem and then what would you do is were just going to say no not to give you anymore because we know like almost everything else that you take caffeine included I can have 67 cups of coffee and I'm perfectly fine because I drink a lot of coffee my receptors down regulate the response to which that's can happen with opioids this can happen with everything and when somebody needs more to achieve the same pain level is not necessary that the third seeking more for the addiction property you literally will start having pain at the same dose I have to keep going up and then we withdraw people get into note they go through withdrawal it's a legitimate addiction go through withdrawal and then nearby Gustavus of compensatory mechanisms that basically just like this gentleman was experienced with high blood pressure now we can't his vision now suffers his quality of life is going down because he's in chronic pain he's having to be wheeled around by his daughter it's in she's in tears as were saying it's just not safe to do your eye right now we wanted someone so badly to do it but high pressure hi ocular pressure and blood pressure can lead to a rupture and then he would just lose vision in his eye altogether so unfortunately we had to just reschedule high blood pressure due to withdrawal symptoms distribute an anxiety component to maintain component to it and when you say that you can't sleep sleep is the most important medicine the one thing if I can get one thing for all my patients to do get a good night sleep because so much stuff goes on that heals your body that makes you better while you can sleep so that's one of the reasons why I'm so adamant that when we launch this health box the D had health box you we will make sure the people can heal their brains get some sleep there to have more energy all of it works together if we can get people feeling better definitely and hereby to touch on that PTSD did it before you get to that hinge is one second one more thing on the veterans here's what I think some people forget whenever the federal government prevents us from doing research on a particular substance it's just that means there is no innovation it's really legally allowed to be had so keep in mind that most of the movement for us to move forward to have evidence-based practice or protocols I should say using medical marijuana helping states like Colorado and California kind of set us on the track way were we can start looking at THC and other substances came from Israel because we prevented it from happening here but they were specifically interested in taking care of people that serve their military which is everyone has to do two years over there we should be taking better care of our veterans here they have sacrificed their time and for the most part several years of earning power to simply serve their country and it just doesn't make sense that when it comes time to take care of them in and I'm in a situation where they are in direct need and we've essentially used them as a country to serve us why we turn them away it just doesn't make sense that we did that's that's the system that they have to exist we were talking there is a friend of mine and Rich Hagedorn out of vogue in Omaha Nebraska one from the date he's part of founding member of soldier Valley spirits words they actually get proceeds to veterans so they got their own there making different whiskeys winning awards doing that kind of stuff and they give a certain percentage all the time to our veterans which is cool and it's only veterans that work so super cool I wish to have them on yeah I know he's really really really funny guy super high-energy two quick things on the opioid thing To do so in the news yesterday that a small study came out oh New York Northeast I can't remember see it's not ethical is Mount Sinai I think him on Mount Sinai where they took a small number of people that were heroin addicts and they actually gave them marijuana okay CBD CBD I hope to see I haven't read the article just on the news I want I need to get that article and they it really helped with OP addiction so we got that question brought up in one of the shows about does does CB do you know you always be careful about making claims but when a study comes out because I'm not making a claim I'm referring to the study the study showed that they were able to get some of these opioid heroin addicted people off of heroin using CBD now I did not see it but it does sound incredibly annoying but that's just have to be no topic for a show to follow up with because I don't know but it sounds incredible and just think four years ago that kind of research wouldn't exist certain that stateside no effect on the news director talk and that most of the research coming out of Israel or Canada now now since Canada's the get into a little bit direction looking at it what was the name of the person that emailed you about have you ever heard of narcotic bowels that was David David H LLC last name on it that's what something you give me permission to do but to David and what he did as he specifically brought them into our attention at David thank you this was an awesome email basically saying that articles date back to 1987 and then several of them the NIH has posted two articles on it and then nine 2007 they were even revised in 2017 and it's a condition called NBS or narcotic bowel syndrome just like I Dr. Brown said coming there's a there's actually a lot of legitimate research that behind it and his his claim here is by physicians and pharmacist are completely unaware of it even being a problem but I mean you are you being a G.I. maybe you did know by this moniker but you kinda seem the symptom occur I have I've had a couple patients and you're almost chasing me almost on the acculturation of the Dragon because this is fascinating you can be taking opioids for let's say back pain the motor vehicle accident you get the chronic back pain drawn opioids and a very weird thing can happen this narcotic bowel syndrome actually when you're on opioids it can actually change the motility of the intestines and we know that which is motility you can allow bacteria to grow which means you can have more gas produced and it actually causes something called hyperalgesia so your visceral sensitivity goes up in a paradoxical way song to say this again you take opioids for back pain but your gut actually ignores the opioids and hurts worse so I've had people on opioids and they look like their pain seekers is like my belly really hurts and you realize we could get you off these opioids and that's what I've done with about four patients the whole point was trying get them off cold and in the medical terms called opioid induced hyperalgesia so it's a characterized by paradoxical response people that are getting opioids suddenly now what's interesting is that doesn't just happen in the gut we have a term for there is a possible tapping other places in your body words like oh now this art will all be lowering the pain threshold in other places where what happens what happens acutely and that in hospital course would be blood have too many opioids one of the first things I complained about it it almost always starts with the nose but it can spread out to the body that's the itching you have had this conversation before many times the first thing that's prescribed to them is Benadryl and unfortunately it's not a histamine mediated itching response at all that will do nothing you need to use unfortunately to offset the opioid drug yet to get a opioid mix agonist antagonist did like it like a new vein or something like that to make the itching stop because the Benadryl simply will just stop histamine makes him tired so that it is fall asleep itchy and you not really doing anything unfortunately it can take someone to another state where since the opioid suppress respiratory drive and not being awake actually will drive down your respiratory rate as well that's a natural response that you get rest so it's just a bad combination Ali around when especially when in today's day and age mostly outside of anesthesia trained people the first thing people reach for is not an all an opioid agonist antagonist to handle it when you and I had a conversation first I thought of I was an intern in San Antonio how about 2 AM called by a nurse we give this patient's pain medicines and I was itching everywhere 0.5 Benadryl what he is normally your intern I learned something early on this is advice to anybody that's doing a career when you find someone who's been doing it a lot longer knew no matter what their title is listen little. I've always so we had to rotate with the military in the military you know if you go in as a doctor you automatically going as a captain so your officer right but you do whatever that master sergeant says yeah so I made my life real easy but when I was at the VA in the ICU I would just I would defer to the nurses that were there for 30 years be like you teach me even do a little longer I've been here a week elevating that eight years but you're exactly right maybe we we didn't want us coming up through the anesthesia training I can remember you would have's fantastic scrub techs have done lots more hearts and I had time and they were there great onset of ALU but you just listen to them because they help you but it makes sense so when I first came in the practice of I was doing a lot of L2 lot ERCP's at medical city Plano :-) RCB is yes it's where it's it's called an endoscopic retrograde calendula pancreas talk big sculptors through the scope that you just go down like an endoscope and you go up into the liver and into the Pancras thank goodness it was fun at that time it was that Dr. my partner Dr. Goldschmidt and now we have Dr. Ackerman who are both experts in it so as it turns out it's a skill yeah but the more you do the better you get but is pretty funny because the ERCP team that was there you know I'm your new and you try to act like you know what you're doing and you like to know get me the jagged whatever and something else but you had a thousand hot water so I was always trust in this nurse had he has been there forever and he would hand me the stuff and he's hilarious is from the Philippines get a real call nature and so what you do is you get into the you get into the bile duct and you cut so you can pull stones out and do stuff like that and Moses said I no longer do ERCP skills we got better experts doing it but I'm doing it and I'm making this cut and I look over at Henny and I'm like that's that's good right knee goes I think you need a little bit more and know it in the just red blood everywhere you go Steph was too much but in the next hour trying to stop the bleeding sores like that run like yeah well you ask the experts are there for a reason people to specialize and thankfully they do give enough time to tackle this will I just want to bring up another interesting news stories uncovered were kind of all over the map here but a story just came out today a woman from Greenville South Carolina is suing Burger King because she claims that she was diagnosed with irritable bowel syndrome after suffering symptoms since eating improperly cooked food at the restaurant she's asking for $330,000 for medical expenses missed work medication gas mileage as well as public embarrassment excessive weight loss and additional damages while all I mean a lot of different things to think of their I may not obviously probably most fast food I don't want to name Burger King specifically the probably most fast food is not the best kind of food to eat but I think most of us should know that I now what he think well what I think is really interesting to me is that we know that 20% of people that have a gastroenteritis no matter what the cause of right May not a big burger again maybe it was whatever the matter what the cause 20% of them will actually develop a disk motility meeting your intestines will not move very well allow bacteria to grow and then you suffer all the symptoms what is striking is she's been doing this for years was several years before that she said that this happened in she was then labeled as debt as irritable bowel that's lysine clinical the time literally all day long people, no I meant I was perfectly fine I traveled somewhere and I came back we talk about veterans there's a lot of people that when they do a tour someplace else they get sick select 20% of the Dr. Mark Pimentel I still think he's doing the study is doing a study on veterans a comeback and the burden of irritable bowel syndrome people get labeled is actually something fixable and that's how we develop ultra until summer in the story and I'm like I was poor woman just a doctrine to yeah ors I fax and depending on what type of bacteria is an ARM is going to call an audible here I think we had to move your study to that to the next half hour so we have enough time that takes me to another topic one of the places that actually carries her KB ending CBD had a question and she her name is Jacqueline up in Oklahoma and she was asking me what is the connection of why people may suffer insomnia and I'm I know you have talked about a couple different mechanisms mechanisms but also thought about another one I want to run this by you so whenever we have inflammation some a marker histamine right so histamine of courses is something that basically races whenever we have cutting abrasion we have in it an insult we can have history right this minicourse is one of those that works in awake center that keeps us awake so if we have chronic inflammation just like we were talking a while ago when you give someone Benadryl they don't necessarily need it you're blocking histamine they get tired if you have chronic inflammation you have this you have a meta-chemical messenger in your body that circulating that your body is producing being histamine making you stay awake and alert because technically your body thinks it's under distress needs to go and do something about it so until you can basically control and slow down inflammation and get some level of handle on that it would seem yet another natural reason why it would make sense to have a healthy Indo cannabinoids system to slow down the histamine response so the you don't have over information yet and I think it's it's that such is his remember the histamines be released by the mast cell right and that's part of a cascade of inflammatory markers there's all kinds Tina fell for aisle 12 mile 23 all these things were learning more and more about and last week was a little bit before we discussed how when you have leaky gut you can have leaky brain your blood brain barrier action becomes permeable to these inflammatory molecules these inflammatory molecules can then reside in the hippocampus which is your sleep center and you don't sleep well and then it becomes this horrible cycle which many Americans are actually a stress is a good thing acutely acutely rise your body adapts to chronic stress no that's really were talking about we just talked about the gentleman that was that the VA chronic pain chronic inflammation chronic stress that's that's the problem stressors are not bad at all when you work out to grow muscle you if you think hard and then you take of you know you rest and then your brain rearranges but I like the histamine example only because for some people that are new to learning why inflammation may be tied to their insomnia most people have at least either experience or had a close one experience taking something like Benadryl diphenhydramine and they get sleepy it's because you're blocking histamine but it think of the thought about that and I guess with your anesthesia training you certainly are much more knowledgeable about the depths of sleep and the stages of sleep and things like that because you have to make sure that somebody doesn't run away bad bad luck there is that's so funny you're going on this route this morning when I was working out I was listening to I listen to a podcast called health hacker members name but he had his guess today was a MD called Dale Broadus he wrote a book it's all about preventing Alzheimer's so Alzheimer's and dementia is becoming one of the leading causes of burden on the US and death and all the stuff she showed something which is really interesting bit typically in the US we start becoming ill around 40 restart in diagnosed with chronic illnesses in the UK it's around 50 so what he was saying is that we may be living long but are six times longer here which ultimately the longer your sick so if you have chronic diabetes if you have sleep issues if you have all the stuff you decrease BD NF which is a substance that cleans up your brain and what he saying it was it's a very interesting podcast is basically everything you said you need to fix your gut you need to sleep well need to protect your brain all those things that we always talk about because this is the burden it's going to happen if you don't do those things properly and he was talk about doing a like this cog not Skippy the colonoscopy to do a Cognos copy periodically you go in and you check different markers insulin levels hemoglobin A-1 C and things like that in a bunch of others but I thought it was just an interesting term I think your parents called us to be like that we don't think any of going in and having a colonoscopy because now it's normal for everybody at one time it wasn't we should be doing Cognos could be in trying to alter the course what interesting well it's a really cool idea especially if you could tie it back to what the cause was what causation was met with the that's exactly was talking about unfortunately you have pain I give you opioids let's go back to the root why do you have the pain man there is the music hey that was at its first hour of getting project episode 12 in the books like us and share on iTunes and on YouTube we will be back in just a moment this is the only 24 hour take anywhere platforms dedicated for food and fun we're spooning our town hall.com, there are downed trees and power lines homes and businesses damaged or destroyed after tornadoes right parts of Missouri overnight they capital Jefferson City was hard-hit often Thompson lives there and says his apartment complex suffered heavy damage through formal offices all look over the one billing that may save one story and I willingness to story this one going one story now my building my room every PC rocket windows blown out a tornado killed three people in Golden city Missouri now flooding is a major concern severe thunderstorms moving across parts of Oklahoma Missouri in Kansas John Walker Lind has been released from a federal prison in Indiana California man spent 17 years behind bars or providing support to the Taliban in Afghanistan he was captured on a battlefield there in late 2001 there is a legislative standoff in Washington Pres. Trump says it will not end until House Democrats stop investigating him any hope that the president and congressional Democrats could work together on infrastructure has been shot down and Mr. Trump says ongoing house investigations are to blame you can't do it under these circumstances because the investigations phony and is refusing to negotiate policy until they're over and the presidents also upset that the speaker has accused him of engaging in a cover-up Greg Claxton the White House lawmakers in New York have given final approval to a bill it would allow president from state tax returns to be released to congressional committees that have so far been barred from getting the president's federal returns Josh sharply lower on Wall Street now down about 370 points loss of more than 1% the S&P is off 35 points Marley stories said town hall.com are you tired of high cable TV rates sign up for dish today and get a $500 bonus offer while supplies last loss locking your price for two years guaranteed call American dish you are dish authorized retailer now 800-570-6630 800-570-6630 – 800-570-6630 offers required by vocation 20 from early termination fee at the auto face friction supply call for details have you done it yet you catch a glimpse of yourself in the mirror I'm I'm one of those people you don't want to see naked I yeah most of us but I mean you look and you're going to die I don't get whatever all its horrible stock Townsend and Brad Staggs to tell you about a different way to shed those pounds this is brand-new technically been around for a couple years or so it was based on research from the University of California that said there is a molecule called OEA that's found naturally in your body produces it in the Mediterranean diet that when taken in concentrated amounts it will actually make you feel fuller and boost your metabolism I lost about 10 pounds so far is an amazing Valley school company said we can take this to market to make this great product will help you it's called read you zone our IDU zone.com our IDU zone.com Brad's workers were comrades work for me countless other people go to read you zone.com and try today you're gonna love it read you zone.com remember that our IDU zone.com it looks like you're losing I am I losing weight I am losing my lost about 10 pounds how are you doing it funny name but I done it with review zone RAD use zone.com and the stuff works it's you get it all that the molecule this and that found in that all I can tell you is it it so it makes you feel full and he keeps your mind off of wanting to overeat and also boost your metabolism as your done and more guide try it today it's gonna work for you like his work for Brad and countless other people read you zone.com are IDUs zone.com all right we are now and to our number two of yet checked project so number 12 with your host Ken Brown I'm Eric Rager check egos at the door because nothing is off the table so we have a study that we promise are going to get to but I've got to remind everyone to like us on iTunes go to iTunes get check project is search for gut check project you'll find is there like us to take a screenshot email is that you did it@gutcheckproject.com through connect and once you do that you'll be entered into the contest where you will receive outrun teal and your preferred flavor of KB MD CBD and that we should call it the signature pack on the KPMG store that's that offers what I'm skewed hunt is more than $100 value as I stumble over my words easy for me to say goodness yes value over $100 and just go to gut check project.com hit us on connect tell us that use that you subscribe to to get your project on iTunes and you will be entered so also you want to just when is Dr. Brown puts it when no matter what go to love my tummy.com/Simoni get yourself a discount on the world's only NSF certified over-the-counter solution for bloating and abdominal discomfort packed with polyphenols but a lot of polyphenols in this box – especially one in your hand but I'll try and teal developed by a board-certified gastroenterologist who happens to be sitting across the table from me after until is NSF certified for sports or if you're an athlete and you need your daily polyphenols go to love my tummy.com/spoony and get your daily polyphenols to help with recovery and athletic performance band what is that dead the doctors name from the exit University about about well but well yeah she's got some excellent information on how Pro anthocyanins which of the polyphenols inside about trying to heal actually benefit athletes when taken at thousand milligrams a day so give the doctor it's basically four capsules about trying to predict correct yeah it's so for capsules due to the polyphenols as the antioxidant component I have a new article that were to talk about at some point where it actually looks because there's some confusion about I did talk to a PhD who is doing some research and said oh we no longer think polyphenols because of the pro-oxidant component to it meaning oh does it actually create a lobed of information as it turns out a new article came out the polyphenols are fasting mimetic molecule meaning you get the same effect as fasting which means you to have my toffee G autophagy cell renewal because the six cells go away that's the pro-oxidative effect but the antioxidative ones so once again it comes back mother nature just seems to do better it's really hard to take a concept in a petri dish and reproduced with humans yeah definitely so I'll try and he'll get some love my tummy.com/spoony so Dr. brass P00 and one save everybody's a winner yes so I don't run you were going two to address a PTSD article and I don't want to get cut short here so because we did last half hour ago and that you can stearate will I was little there but first I wanted to this is dangerous this is by no underlings in Chelsea this is a note kind of interesting I want to present a scenario you got me thinking about how you saw that guy in San Antonio with all the keys and he just walked up to the trash cow handout cameraman cameraman and you're trying to do a back story for likewise he otherwise indicates why you will regret it now I doing other things I want to tell you a story and then I want you to tell me the back story okay okay this is an NLP exercise whose Robert Seale Dany Michael Barnhouse stuff yeah signed neurolinguistic programming and what that is certain words or certain sounds are certain memories will create emotions around this time okay I just want to back so I just want to know what's actual happen you sitting there and out of nowhere a woman runs up to another woman and slaps her that's it tell me what happened to me why Tillie what's going on with that scenario well I can't believe you don't remember because the woman that was sitting there had basically commandeered the other woman's vehicle from Walmart and had parked it in the wrong spot and it was totally and the woman came in and did the slapping told her that he I think you forget the you were on a boat in Africa oh that slapping yeah yes that slapping incident yet that was the woman who was supposed to fed the lions but because she didn't the woman he came in and slapped her family was bit by few liens and that she was upset that since the one who just sitting there didn't feed them she basically allowed the lines to go hungry and they went after humans wow that so it's because somebody did not do their job properly and that affected her so she was slapping her out of revenge he has a sad day that everybody was okay but you know it's it was very scary interesting nice boat ride out thinking I would I do remember that so that that is your take if you ask a bunch of people gotten you get all different kinds of sorrows yours interesting with the with the.feeding the lion of the lining to the people that's convinced but yours is a story of basically it's of violence right what really happened is that you are on a boat in Africa a mosquito landed on the cheek and she went over and killed the mosquito because that is a malaria infested area and she saved her life it wasn't a violent act she was actually protecting that woman so there's two things of this number one the neurolinguistic programming your prior history of anything like that filled in the gaps right if you're in that area and you witness that you probably think old the woman will save the woman's life sure because we can't have the mosquitoes passing malaria anyway you told it out I immediately place them into an adversarial role between each other no doubt I was doing a NLP lecture which is with this came up and the guy actually open the lecture with that just I just for listeners I had no idea what he was going to tell me to step down, that you just left field which is all about that leads into something super super cool okay so today the story came out about malaria I and for the first time ever a vaccine is been developed okay so were sitting here were like malaria whatever malaria affects nearly half the world's population and a new vaccine may be able to actually stop us and save millions of lives and malaria is one of the reasons why certain countries can't get out of economic crisis because it kill so many people kill so many kids it's super scary I didn't mean one site and I was thinking about it because the NLP story exactly that with the guy said in the lecture by and then I read this article malaria no like others fits perfect and your data into your hammer man story malaria really is humanity's curse we don't think about it in the US but it kill so many people in fact when you look at the world's dangerous animals like always but homes yes mosquitoes only one yeah mosquito rains me they kill more people because of malaria then every other thing that's out there job and about volunteerism when people go to Africa and they you can take I think it's an antimalarial pill I don't know about it but I know that you basically stock up on it and then you take it and then you go and then one of the most important pieces of equipment is the mosquito nets around where you sleep so that you don't get malaria but before you get really deep in their always wondered of taking care of the few young kiddos who had sickle-cell anemia here stateside and usually not not a good situation and but that being said if sickle cell anemia they think was an adaptation mutation so that humans could survive that's an exposure to malaria epigenetic thing where you're at in the environment your genes turned on so that if if you have sickle cell I wondered is the survival from malaria it does do that offset like if if those same kids were exposed to true malaria with that allow me to have a never and never quite figured out why the adaptation is so beneficial because in most cases not every case but in most cases the lifespan is rather short do you know what is really cool is if you get an international infectious disease doctor start asking questions like that it's really wild especially if they get an epidemiology background as well right so you got an ID that deals with stuff like that and they can explain that's a little bit out of the scope of my medical practice not interesting thought but it's fast and because this up I guess in Afr
Marc is the ONLY known 5 year survivor of de-differentiated chondrosarcoma. A former D1 football player for the University of Texas, father of 3, and devoted husband learned almost a decade ago that his life was most likely to soon come to a close. With his optimistic and make the most of it attitude, Marc is beyond 9 years of being in remission for a once thought to be incurable condition. Marc has since turned his experience into giving back and has become a private pilot and flies today's cancer sufferers to treatment from North Texas (Decatur), and volunteers his time with many charities including Raquel's Wings For Life. "You're gettin what you're gettin, cuz your givin what your givin..." https://raquelswingsforlife.comhttps://kbmdhealth.comhttps://gutcheckproject.comHey hi Mandy if you don't know me it's probably because I'm not famous but I did start a men's grooming company called Harry's the idea for Harry's came out of a frustrating experience I had buying razor blades most brands were overpriced overdesigned and out of touch and here is our approach is simple here's our secret we make sharp durable blades and sell them at honest prices for as low as two dollars each we care about quality so much that we do some crazy things by world-class German blade factory obsessing over every detail means were confident in offering 100% quality guarantee millions of guys have already made the switch to Harry's so thank you if you're one of them and if you're not we hope you give us a try with the special offer get a Harry starter set with a five blade razor weighted handle shave gel and a travel cover all for just three bucks plus free shipping just go to Harry's.com and enter 5000 at checkout that's Harry's.com code 5000 enjoy and here we are it is episode number four of get Jake project here with Dr. Kenneth Brown I am Eric Rieger again hey doing today I'm doing fantastic episode number Quatro number Quatro that is Spanish for radio no as mentioned before that is Spanish number four yes you are you pretty well versed in Spain Georgia were bilingual home absolutely well do you like to speak Spanish and I'm probably the worst speaker in the house. Let's say okay hey just a quick tough nod off the jump don't forget that today's episode of gut check project is brought to you by John Teal get your own genteel@lovemytummy.com/spooning use code spoony same sums of money so have I been taking some voiceless and also trying to nail that the throne going it's going horrible was that it was that your that you shot that was my best shot is that you back also brought to you by KPMG health brand-new KB TCDD but now you can get to the gut check project.com and be linked directly to the KPMG store and find your own KPMG CBD awesome baby if I gargle with that before trying single improvement it could work well we got a great show today and were going to get to him in just a moment that our guest today is Mark simple minimal touch on that here in just a moment incredible story of survival new lease on life and what he's doing after his battle with cancer but if you been watching get check project for all of the last three weeks you know that dark to our first half-hour is news and notes for gut check project so Dr. Brown what's happening new in the Brown household here since Elisha well in the Brown household what's really exciting is my daughter in her improv it's just theatric class she's a sixth-grader she came home and taught me something really really good that basically whatever you doing improv what you have to do is say yes it's yes and secondly if dues trust third thing is listen and then the fourth thing is make a statement and I heard that no like I need your teacher to come over to KBS headquarters we can work on that as a teambuilding exercise improv exercise to make a team yes and I love that yes and and then I want to trust what's coming next I loved this pretty while the basically an improv class she is learning just great communication skill left I thought we were laughing about it last night so Zachary know to come home with like what you learned today and that's were talking about the really cool thing our house is my son is currently playing in the finals of a really big tennis tournament out in Indian Wells California the Easter bowl to big one so at 11 o'clock our time he will be playing in the finals were very very proud of it in both singles and doubles so the brown households having some good times right now about you well number one shout out to Lucas and Karla those are both the great notes to to be able to carry around the data know that you're proud of both of them for me both of the boys have moved into off-season basketball there really fired up they've been out of basketball all of about 10 days which I think if you shoot who apparently that's way too long so they both get started but something that we did as a family that was a lot of fun just a little week ago I should've mentioned it last week show I'd never done it before my oldest son actually done it before a couple of times and that is we all sat down relaxed and got pedicures and I'm here to tell you that include dad included nice if you haven't done it don't knock it did you try it because I'm going back that fell awesome and now I mean table I got really ticklish feet but I didn't know something learned about myself is that my left foot is more ticklish than my right because as they began to exfoliate the bottom of my foot especially the left side I was crying from laughing so hard as I got in my mouth and of course the other woman doing is looking up and laughing again with everyone else as they exchanged their own jokes in another language I'd alsojust like Spanish and did it at my expense was completely worth it and I will deftly be back so I almost got a pedicure once I know standing out front and I looked at my feet and it remind me of the scene from dumb and dumber with a grinder to toenails a wireless want to do that to anybody to put the clause back in the shoe keep on walking now is he always worried he wanted done it when I reveal like a Frito toenail or anything else like that but I think I walked away as best we can be that had since probably I was a baby's kids really good pedicure now don't even have to ask what you been up to because you and I rush to hang out we were this last weekend he and Emily were business makes a little bit of pleasure yeah and that was in the Utah powder mountain that was awesome incredible skiing lots of powder fantastic so much snow for late March he was beautiful is a great place to go and visit not crowded either now our ski experiences were little bit differently where they were loaded and so to put it in context Eric was like Kelly dropping and taking these tractors up and I actually had escorted down the mountain by two wonderful people Lindsay Vaughn and Susie Chapstick but it was Juliet and Karen are awesome so I survive it was a big thing didn't break anything didn't do anything but the our expenses were totally different you came back just on my couch that was incredible backcountry all powder and I was like oh yeah my little different I had two women sort of guiding me down the mountain the whole way so there's no shame in effect I'll even say whenever you but whenever we yeah got into our skis the first day you had planned on even making a few runs together it was snowing so hard I stopped to buckle up my helmet is safe and I looked up and Ken and the other four people that I was skiing with were gone they probably want you probably want 20 feet away from me but it was a complete wideout for the first what our we skied oh no I Don't I ended up staying in that area and like true why don't I lost everybody like it was you couldn't see your hand in front of you who not only did I not been skiing over 10 years that's not the way to start now and shout out to Blake Kingsbury for finding me he looked like a yeti lost in a snowstorm and that basically was my beacon on the way down I had no idea how to get down but dad know that was that was a great time up it to powder mountain if you like skiing snow skiing deep powder skiing you take yourself a big powder mountain we move on here a little bit to basically the news because yesterday while we were working at the Indocin or you ran up to me you said look at this study this is a little bit more in terms of what we've been talking about bore catalysts and what causes cancer I will let you take it over from there because it's pretty pretty incredible piece but thought it was so it was just published a photo so appropriate to have Mark on the show were duly talking about cancer and surviving cancer well in this just recently published in the Journal of science this month they did a study with a looked at how high fructose corn syrup actually enhances colon cancer in mice so what they did is they took the equivalent of one soda a day and they gave the mice that amount of fructose corn syrup the issue is that they had genetically engineered these mice so that they would get polyps and cancer sure which is funny because you wonder like your to be genetically engineered you never think that your to get that like I'm genetically engineered to be faster genetically engineered bigger stronger than one poor mouse is like on genetically engineered to get cancer and that's how they end up looking at these different studies so what they did as they showed that by giving the high fructose corn syrup dramatically raise the amount of polyps and cancer over 80 times the mice that were not given high fructose corn so this is with an equivalent of one soda one soda a day so it's absolutely incredible because I love your member but a year ago study came out where was looking at how the rate of colon cancer millennial's has been going to share we did a video on that on YouTube or Ricardo was we did the interpretive jujitsu and what it showed is it dealt with the millennial's were getting a higher rate of colon cancer because of obesity they should with these mice they did not become obese they did not develop metabolic syndrome it's strictly due to the fructose and the sugar that they were consumed then they were able to actually show that I take it was fructose the tumor cells love it so much that they could put a radioisotope and they could show that it just got sucked up it turns on certain genes that allows the tumor to go undetected absolutely fascinating because the fructose and that the high fructose corn syrup they believe could be very similar to others like table sugar bottom line is tumors love sugar and this is the first study that's been done were really actually look at that and it's actually fascinated Mileage Is about to Come to Clear My Throat What This Actually Shows Is Now They're Looking at How to Actually Adapt Fasting Plus Ketogenic Diet When You Have Two More Surprises If You Can Give Him Sugar That's Just Going to Absolutely Feed It like Crazy so Fascinating Study Just One Soda a Day Can Do This Just Write down A Few Things Here Because You Said A Lot Of Impressive Information so If We Were to Backtrack and We Can Take Away That Tumor Cells Love Sugar and Live They Love Circulating Glucose That's Going to Be Their Main Desired Use for Energy and That's How They Grow They Don't Have Energy They Can't Grow Something Else That You Said and There Was Was Really Captivating to Me and That Is They Were Able to Take the High Fructose Corn Syrup after Consumed and Basically Activate A Process Where the Body Could Not Detect That They Were Tumors Themselves so Not Only Were They Now Stealing the Energy so They Could Continue to Grow As a Cancer And Develop into a Bigger Tumor Diesel Tumors Now Are Being Able or Allowed to Activate Something Where They Were Basically Incognito Not Being Able to Be Detected by the Mice and Their Immune System Greg Will Exactly Actually Gets into so This Is Where I Start Getting into the Geeky Stuff Little Bit There's an Enzyme Called Keto Hexokinase Which Will Change Fructose into Fructose One Phosphate While That Turns on The Gene in the Tumor to Use the Glucose More so That's What Tells It to Absorb It More so It Actually Little Cascade and They've Actually Shown the Third Trying to Develop Drugs That Actually Block That So There's Ashley Phase 2 Clinical Trials Going on with Her Trends If They Can Block That One Little Enzyme Does That Sure so What Then The Able or Would We Then Be Able to Extrapolate That Maybe the Reason Why Millennial's Are Now Seeing an Increase In Colon Cancer Is Because Generationally Probably If We Were to Back It up Two or Three Generations We've Seen an Increase in Sugar Consumption People Believe That Sugar Is Related to Inflammation That Those Two Things Combined Together Are Now We Are Seeing an Increase in These Types of Cancers They're Being Detected Because When You Consume Any Type of Food He Goes Straight to Your G.I. Tract Would You Say That This Is Somewhat Related or Possibly Related Will That Was the Funny Part Is This Study Gets You Thinking about That Because When They When They Were This Is the First Time That We Have Seen People Having a Higher Incidence of Colon Cancer Than Their Parents Rights for Simon so It Was Speculated over It's Gotta Be Obesity It's Gotta Be the Metabolic Syndrome This Is the First One Would You Look at Something Ago Now Looks like It's the Way That Were Processing Food The High Fructose Corn Syrup Is in Everything Everything but It's Really Concentrated One Can of Soda and so the Consumption of Soda Has Increased since the 80s Significantly So Is It Our Diet That's Doing This Were Trying to Label It with Different Things Owed Sedentary Lifestyle or Possibly It Smoking or Whatever Now Looks like Our Diet Is Really Contributing to the Amount of Cancers That Were Seeing You It's Wild If You Just Look Back I Can Never Looking Back at Pictures of My Dad or My Mom Growing up and What Family Pictures Look like Whenever They Went on Vacation He Would See Everyone and All the Ancillary Players in the Photographs Around And Who They Considered to Be Overweight Back Then In the 50s and 60s and Stephen the 70s And It's Starkly Different Than the Then the Body Type so What People Look like Today and What We Consider Overweight and for Me Personally I Really Don't Even Point It Those People It's Just Our Food Supply Is so Inundated With Lots of Things That You Just Are Unaware Could Possibly Be Contributing to Natalie Being Overweight but Probably the Diseases That Maybe Are Going to Have That You Don't Even Know the Are Manifesting Right Now Unfortunately Possibly Even Colon Cancer for Millennial Becomes Really Kind of the Disheartening That They Are Actually Allowing or They'd the Insurance Companies Are Allowing Us to Screen People at an Earlier Age and They Wouldn't Do It If It Weren't In Balance with with Cost It's Always More Cost-Effective to Catch a Cancer Early Then Late so If They Are Allowing People to Not Have To Wait till 50 To Come in and Just Get Their First Screening and Now They've Lowered It Doubly 4545 and If There's a Family History of Violence Then It's 42 Start to Begin and That Was Not That Way It All 10 Years Ago for Sure It Was an End It's Fascinating Because Here I Am I Just Got This Article Yesterday You and I Were I Was Doing Colonoscopies Yesterday and I Just Started Jumping up and down Because I Realize That When Patients Go into Recovery Most of Them Are Given a Can of Soda after They Get out There Sentiment. To That Right Now Were to Put a Stop Ides I Told All the Nurses Alike No More so to Tour Patients Were Trying to Stop Colon Cancer And Were Causing It by Drinking Minnesota so We Should At Least Lead by Example Would Be Given Patients a Pack of Cigarettes with Her Leaving the Endo Center I Got Admit It Did Nobody in the Hospital System Seems to and from RT Friends at Them so I Bet If You Want to Find the Smoking Dock Just Look for the Respiratory Therapist outside of the Hospital Why That's the Same at Every Single Hospital Ultimate Training Every Hospital Billing I Don't Know Either It It's It's It's Really Kind of Fascinating Hey Before We Might Give Any Other Quick Takeaways from This Particular Study Rotates Just That This One Is Just so Impressive Because It Really Shows That the Way That We May Be Treating Cancers in General Is Wrong so I Talked to Some My Cancer.Friends of My Katie Put People in a Ketogenic Diet Greatly When the Do That No We Don't Do You Ever Use Fasting When Somebody Has Us and We've Discussed before That the Fasting Mimicking Diet Actually Has Been Shown to Improve The Effect of Chemo And Decrease the Amount of Side Effects but That's Still Not Being Implemented so Here Is One Example It Always Starts out As Animal Studies Are Which Is When Humans but I Think That This Is the First Step to Show Hey Proper Treatment of Cancer Is to Starve It Not to Just Dump a Bunch of Sugar on It Which Is What Were Kinda Doing Yeah Isn't It Interesting That Maybe Even When Your Body Is Trying to Recover from an Episode of Cancer Not Just When It's Chemo Induced but When People Begin to Lose Weight Everyone Immediately Becomes Concerned Possibly It's Sometimes the Body Just Knows What He Wants to Do And by Starving These Tumors from the Circulating Glucose Is Its First Mechanism of Defense We've Got to Stop Feeding This Is Base Leads Rogue Cell Or Whatever It Is It Happens to Be Going Out Of Control Yeah… That I Think It's Faster Oh Did You See the Speaking Fascinated to See That That's California Man Was Awarded $80 Million Because He Had 56 Acres That He Was Using Roundup for Decades $80 Million That Is so Wild That It so It's an Incredible That It It Took This Long to Find out about and We Were Spraying It on Everything so We've Got Dividing up the Deck Stacked against You If You Got a Carcinogen on Your Food Chair and Then If You're Going to Take the Corn Fructose Which the Horn Was Sprayed Right Now We've Got a Double Whammy Going on Right There You I Can or When the First Big Move in a Big Push of the Non-GMO Foods This 90 Mode Foods That and I Was Really Rather Ignorant in Terms of What That Actually Meant And It Was Really Easy to Find Detractors from People Who Were Reporting That Movement like All They're Just They're Just Afraid They Were Doing New Technology in Food Development and Etc. so Much More Than That It Comes down to Protecting You and Yourself from Carcinogens Which Can't Taste You Can't Detect You Have No Idea You Have the Healthiest Person in the World Is Exercising Not Smoking Trying to Eat Right And While They Are Eating the Foods That They Trust Such As a Great Piece of Broccoli Vegetable Actually Consuming Glyphosate or Roundup In Their Food and They Get Sick That I Read Another Article Which Showed If You're Exposed to Round up on a Regular Basis You Have over a 41% Chance of Getting Lymphoma Hodgkin's Lymphoma I Don't Know Where They Got That That I Need to Find the Actual Article but in This Particular Study They Were Referencing Ups I Think That Was Used As a Type of Cancer That That Man Got And That's Why He Was Awarded This so Probably for a Follow-Up Episode Because What We Do Here Is Always Try to Speak into the Facts and Know That We Seen the Trend on Various Types of Cancers Including Lymphoma Have Been Increasing I Just Don't Have It on Hand That We Will Tackle That Probably in a Future Episode in Terms of the Non-GMO Versus GMO Roundup Life Estate Is or Has To Be Something to Though Because You Have the Lymphoma Belt in the United States Which Is Nebraska and Iowa Run from Agronomy and That's What University Breast Is so Good at Transplants Because They're One of the First Places to Do the Autologous Bone Rail Transport Because They Were Seen so Much Leukemia and Lymphoma And They Didn't Technically Everyone Said They Couldn't Explain They Didn't Know What It Was But It's the Same Thing Is Whenever They First Figured out the Black Lung Was Kind of the Problem In Minutes It's Really No Different EE No One Created the Industry to Make People Sick but Once People Began to Get Sick It's like What's the Acclamation Here Are Just Kind Crazy Everybody's Getting Sick and You Realize It's a Sit in the Air and You It's It's Really No Different from the Time That You and I Went to Virginia We Worked in the Coal Mine That One Day Yeah with Zoo Lander Haplotype Man Man's Underrated Moving Speaking of Movies Are Yesterday's Sent Me His at His Top Five Movies or Lease That I Reminded Him of That He Wants to Cover Why Does He Send Them to Well He Said to Me Because I Was Just Curious on What He Would like to Talk about Ancillary to Some of His Incredible Story Already but Will Dig in and See How How Well He Actually Knows These Movies Whenever the Last Half Hour Rolls around and See What Mark Knows about His Own His Own Favor. He Descended to Her Did He Fill out Our Gut Check Project Intake Form That's a Good Question so If You Have Somebody July Can Nominate to Be on Our New Show Gut Check Project You Can Visit Us a Gut Check Project.com Go to Connect and since Some of the Way That You Think You Be a Good Fit for Get Your Project to Be Interviewed by Your Very Own Dr. Brown and on That Form of Course We Find out Really Little Bit Everything about Who It Is Going to Have on Show I Do Know It's the It's the Eric and Dr. Ron I'm Here to Just Pull up Movie Lines Occasionally When You Say Things like Black Long That's That's All I Could Think about Them like Julian Yeah Well You Know That That There's Nothing Wrong, Challenge You to Ask the Hard Questions Okay for Any of Our Guests Yeah What You Say That You so We I Think in the Future What We Should Do Is You We Should Have an over under Policy Only Jessica Make Riley Barbara Walters Style Okay Really Did Indeed Make Sense That Something I Met Me Physically or a Mean Just by My Emotional Place Was Funny Because I Actually at the Conference We Are at 01 of the Things Was They Had a Bunch of Movie Directors That Were Actually There They Were Discussing When They Start Doing like Dr. Series Interviews When the Guest Starts Becoming Uncomfortable That's When They Get Their Best Footage and They Really Start Pushing the Boundary Right There so That No Question That Make Sense Though Because It's Gonna Be the Emotion I Said, Raw Motion Is Coming out yet Exactly so If You Can Just Get Everything That's Real Let's Put on Them or Not Billy Gilbert in the Show Here It's Somebody's Review on Some People to like the Movie That Is What It Is but It's Real So before He Finishes the Last Half Hour One of the Main Questions That We Got since Our Last Episode and That We Get A Lot on Polyphenols CBD Really Bob about Your Hobbies but the One That Really Stuck out to Me That We Had Asked I Think Six Different Times Was How Does CBD Address Anxiety and We Don't Have a Whole Lot of Time Right Now but That You Take That You Would've Drilled a Hole Show on That but Basically the Way That I Tell My Patients Is CBD Just Sort of Presses the Reset Button and Puts Everything Back in Balance and If You Think of It Anxiety Is Just an over Firing Nervous like Sensitive Nerve Always Does Is Just Calm It down like a Traffic Cop so That You Just Get All the Anxiety Is Just a Perception of Neurons Firing Right below the Extreme Version Would Be Seizure Early on Just Because Everything down Gets to Go Back to Normal Now so I Kind of Explained It to My Patients Might Just Try It If You Have a Deficiency in Your Endo Cannabinoid System Chances Are You Can Have a Pretty Good Response with Wild Thing Is the Just of Multiple Applications for Utilizing The Indo Cannabinoid System Which Everyone Has In Their Own Body Basically Resetting Just like He Said to Make People Feel Better and There's a Bunch of Different Ways to Make It Happen but Rather Than Make It Sound like a Magic Pill for Everything We Really Want to Break That down and Build Keep Those Questions Coming Dealing with Anxiety Is Something You're Going to Have Someone on a Think in about Six Weeks I Think so You and at That Point Time Will Get a Much Much Much Deeper but Any Other Applications of CBD and Questions like That Combine with Polyphenols… Gasifier Questions Because This Is Holding Figure Who Do Other Episodes Definitely What Is the Old Anybody That Swimming Towards Us Asking a Question We Want to Address It and We Have the Ability to Bring Some Experts in and Were Just Gonna Make Sure That We Do This and Try to You Have Some Fun but Also to Work, Science Here and so We Want to Make Sure That We Use Science and Studies to Explain Everything in a Very Delay Term Hopefully We Can Do It Because the Other Cannabinoid System Is a Tough System to Explain He Said Were There Hopefully and That's Something That We Want to Do Today with Today's Guest Is Going to Join Us in the Next Half Hour Will Bring All Hope to Everyone This Is Our Next Guest Is Mark Simone and He Is the Only Documented Five Year Survival Are Survivor from D Differentiated Chondrocyte: Please Get an Incredible Story to Stick around He Is Taking His Journey and Turning It into His Way to Reach Others and Deliver Now You Can Fly Anywhere in the World and Paid Discount Prices on Your Airline Ticket Book a Flight to Date Alignment Harassment to Read or Anywhere Else You Want to Go and Pay A Lot Less All the International Travel Apartments Right Now Low-Cost Airlines 800 452 1075 800-452-1075 That's a Got an Old Car Donated Whether It's Running or Not to the United Breast Cancer Foundation and Save a Life They'll Even Come and Pick It up for Free The United Breast Cancer Foundation Has Saved Hundreds of Women's Lives through Their Free or Low-Cost Breast Screening Exams but Now They Need Your Help The United Breast Cancer Foundation Wants to Save More Lives through Early Detection by Offering Women Free or Low-Cost Breast Screening Exams In Donating Your Old Car SUV or Truck Whether It's Running or Not Helps Pay for Them Plus You Get a Charitable Tax Deduction Help the United Breast Cancer Foundation Save Lives by Donating Your Old Car SUV or Truck Call Now for Free Pickup 800-245-0823 800-245-0823 800-245-0823 All Right Now That Number Again Is 800-245-0823 Never Forgotten Apparel Is More Than Just a Premium Women's and Men's Clothing Line It's a Movement to Remind Us to Where American-Made and Serve Those Who Serve Us Our Heroes Never Forgotten Apparel Gives 20% of Their Total Sales to Nonprofits That Support Homeless Veterans and Off-Duty Firefighters and 50% to Individual Veterans and Firefighters in Need Nationwide Checkout Never Forgotten Apparel.com Use Promo Code Matt and ATT And Get 15% off Your Purchase Alright We Are Back for the Second Half Hour Episode for Gut Check Project I Married Grigor Joined Here by Your Host Kenneth Brown and Now We Have a Fantastic Guest Joining Us Today His Name Is Mark Silliman and As I As I Mentioned at the Bottom of the Last Half Hour. He Is the Only Five Year Survivor Of D Differentiated Chondrocyte, The Only Five-Year Survival on Record Eyes Got an Incredible Story of Actually Known Mark for Almost 20 Years I You're an Entrepreneur Your Husband and Father of Three Former D1 Football Plate Would You Where Did Apply Zero Other School like Other Than the University Of Texas I Didn't Do Nothing about Him You Had a Bright Did Not Know the University Nebraska Has One That Texas Tech Has Programmatic When You Get That UniFirst Nebraska That's Royal Memorial North Because of the Cornhuskers Mark Has an Incredible Story and To Briefly Mention I've Known Him for Almost 20 Years Actually My Wife and I Bought Our First Home From You Back When You're Dabbling in Our Building Homes and Even Had Cereal Lunch Manure for a Long Time Go Ahead and Looking at Bring a Jump Forward a Little Bit But Once You Take from Their Which Part the Serial Entrepreneur Report What Are the Cancer Part Well in 2010 I Guess I Would Diagnosed with Bone Cancer Okay and Originally It Was Just Gonna Be a Simple 19 Hour Procedure 15 Hours by the Surgeon Four Hours by the Plastic Surgeon There Were to Take out Half My Pelvis so Actually Had a Hemi Pill Back to Me with Allograft I Was Stuck You Real Quick Good Is Working to Get It That's When You Want Is Not What You're Going to Want Something Different Well Now It's It's It's How It Kinda Hit from You Little Bit So I Remember Bringing My Oldest Gauge over to Your House and This Would've Been an Earlier 2010 Right and You Were Laying on the Floor of Your Living Room And You Kept Saying Rear My Back Honest I Don't Know What the Hell's Going on This Only Place I Get Comfortable Take a Nap and You Are Laying on the Floor of Your Living Room with Her Legs Propped up and Physician Interposition Had Scanned Her Back I Was Trying to Find out Where the Pain Was Coming from and Got Different Diagnoses of a Stretches and Other Things like That They Weren't Working And Then It Led to Someone Look Old and a Little Bit Different Location So I Guess in January of That Year and Coach My Daughter's Basketball Team And They Were Doing a Drill in Particular like the Way the Drill so I Hopped in June This Year and under the Real And Course There 10 or 11-year-old Girls Must like Herding Cats Betting on so I Get up the Next Morning Get This Back Pain Thinking Whelming on Little Older and Will Shape Just Pulled Something Couple Weeks Later Be Fine That Didn't Work So Would It Gotten so Painful and I Was so Restless That My Wife Kicked Me Out Of Bed Not Move the Couch Could Getting Comfort There Then I Moved to the Floor and That's What You Remember Him Sleeping on the Floor No Jumpers Are You Comfort Well up into Two or Three Different Doctors Had Had the MRIs of My Lower Back and Had SI Injections I Went to a Chiropractor for Couple Three Weeks of He Said I'd Be I Can Get You Straightened out New Massage Therapist Went to Massage Therapist Every Day for a Week and She Said I Can Get That That Muscles in This like a Rope and I Can Get How Old Were You When You're Going through the 4445 And the The Massage Therapist Is Heather's New Work Sports Medicine Guy across the Street Want to Go See Him I Walked in And He Looked at Me and Says Will You Come to Get Your Gates, Funny And He Took Extreme up My Pelvis Which Nobody Every Identified My Pelvis Because the Pain Was in My Lower Back And Send Me Cross to the Hospital to Do a MRI of One of My Lower Pelvis Now And I Come Back to Him and in the and in Small Town You, Know Everybody Lives There Will the Radiology Tech Pulls Me Out Of the of the Tube in His Shoes, White until Something Wrong And His Name's Mark Also And Marquis Prompts I Can't Tell You You Just Can't Go Back across the Street See the Doctor Have All the Film Thing Else Will He Pulls up the Films and I've Got This and What Just Lit up on Screen This Tumor in the Pillows That Was the First Indication of Where It Was Always Just a Muscular Muscular Problem and Not a Bone Problem or Cancer Problem Bryant Family History of Bone Cancer or Anything like That Don't Cost My Mom to To Diet Coke Today To Brain Cancer. And She Fought That for 10 Years and Multiple Servers But No Bone Cancer They Can Is It Even Common for an Older Person to Have a Bone Cancer Both Extinct It's Very Rare The Type of Cancer You're Talking about the One That You Ended up Being Diagnosed with What's Unusual about It That Involves Both Bone and Cartilage Nice Leather Coat the Deed Differentiated Type of Cancer Router Actually Goes into Both of Them There Is a KJ's Disease When You're over the Age of 60 That Can Turn into Bone Cancer but Most of the Time It's Kids That Actually Came to Bone Cancer That's Called Osteosarcoma so This Is A Completely Different One It's Very Unique Very Very Rare Well the Congress or Coma Is As Rare and That Was the Original Diagnosis from the First Biopsy Which Is like You Said Boeing and Cartledge and F They Took the Tumor out and Did a Full Biopsy Then They Decided What We Pulled out a Bunch of Homogeneous Sales at That Point in Time and so Controversial, Is Not Exactly What It Is No Matter/in This This Loaf of Bread to Define the The Real Answer and It Should Be Differentiated Which Means That They Can't Tell You Where It Came from Whether Described It to Me Was If What What's the What's the Cell in Your Body That the T Cells That Produced the The so the Osteoblast No Over-The-Counter Blessed Usually It's It's a Blast That's the Precursor No so If I Have a Cell in the Body of Stem Cell or Something That's Going to Create a Fingernail As of the Stem Cell Yeah Okay so the Stem Cell It Is Releases Sale to Become a Fingernail or Hair Follicle And That It Was It's Differentiated So It Goes from What That Stem Cell Is to the Fingernail Will It Fall Short That's the D Differentiated Part so They Don't Know Where It Came from It Ends up And All Your Organs at Some Point Time They There Wasn't There Is No Cure That They Have Found This Point They Just Keep Having Surgeries and Taken Stuff out So What You Think You Know Your 44 Years Old Got Young Kids What's Really Going through Your Brain I Mean Let's Walk Us through Somebody That Actually Unfortunately You're Still Here to Talk about It What's Going through Your Brain That You Had a Doctor Come in Well So Entry Part of the Story I'm in Amman for a Week Four Weeks Actually in a Body Cast, but I'm Laying in His Bed and Can't Move And Now Let the Bones Everything He'll And the First Time the Doctor Comes in Orthopedic Lady She Brings a Guy with Her Big 6 Foot Seven Guy Hi Mark I Want You to Meet This Guy from the Blood Bank Okay Great a Home or Not She's Always She's Just Been No She's Trained in All These Fellows She's Just This Incredible Physician Innovative Because Five Years Prior to The Surgery That She Did for Me They Just Took the Leg off Understand. So You Run Rampant Leg She Had Created and Innovated This This Particular Procedure So the Guy Comes in from the Blood Bank And He Says I Think We've Infected with HIV In One Yeah Blood Transfusion I Think We've Given Your Chubby So I'm Kind of Freak in a Little Bit of Artie Get This This Rehab This Will Be a 24 Month Rehab and Learn How to Walk and Develop a List of Internet Your Company Thanks and Thorne Legibly And the He Was Kidding Right Was a Silly Bit Series And so We Can Freaked out so It Goes Janice and I Gonna Freak out All Just This Conversation but You That I Know It's Only Kind of Well He Comes Back in 0234 Days Later and Says Ride so We've Retested Your Blood It's Not Showing up There's No Markers in Your Blood Will Continue to Test You Will Think You're Okay I Think We Have Something False Reading Which Is Probably Not Coming He's Probably Just the Messenger They Probably Have the Biggest Guy There's like Every Head Every Time We Infect Some Truth HIV-AIDS Has Represented How Often Does This Happen in That Particular Blood Bank Is like Sorry I Got a Get to Know the Room Overhearing. We Have an Assignment You So He Leaves after I Come in the Clear but This Kind of a Roller Coaster of Stuff That You Know You Had the Surgery 24 Months Now You Have a Chevy or Whatever You Get Is No Fight This Fight She Comes in a Couple Week Later Zone Brings Another Doctor and Says Hey Mark You Need to Get Your Affairs in Order Oh Because You Got about That Best Six Months to Live Unlike What Was Going on and so You Ask about What Was Going to Your Head Are You There's Denial First You Told Me HLB's Are Not Buying Your Story Anymore Now You Tell Me That I Got Six Months to Live on the Bind That Story Anymore Either And the You Know He Leaves and Then We Go through All the Scenarios over the Statistics What's Is This Legit How Do You Know Is Is a Misdiagnosis We Believe in Miracles Mistakes And He Wouldn't Talk about Any of That Stuff Just Works on a Positive Attitude No You Have Good Family Good Support Group and We Need to Pray to Whoever You Pray to And the In Order to Go As Best We Can Only Point I Would Become Polytheistic Sure Start Praying to All of Them Well and He Leaves Right and so There Is a Guy in Town Aaron Milstein Was in Town Visited Me in the Hospital and This Guy Delivers Loses Me an Error My Dad I'm 10 Crap And My Wife's Back Home And She Had Heard This in a Cigarette I'm Not Saying a Word Aaron When You Go Home You Not Saying a Word to Your Wife I Want This out to My Wife Comes Back in This Weekend and Dr. Robbie by the Way You're Gonna Deliver the News I'm Not Going to Write so He Leaves And so You Go through the Know Is Calico 5° of Separation You Denial Whatever What You Gonna Do Now Get Your Fair Share Is My Tell You That You Get Zero Liberty Anything but Your Kids And in the Lives of Things That Night I'm Laying in Bed and Talk about Having No Begin Being the Religious Was out Born and Raised in the Church and Hence Have a Pretty Good Religious Background but I'm Pitched at That Point I'm Having a Fight with God More Argument The Stages Brother and This Isn't Happening to Me And I've Got a Wife I Get Three Kids If I'm Good – I'm Okay Back but I'm Not Okay Leaving Them Alone Without Needed to Take Care Of My New Summer Influence Rest Their Life And the Time Marcus Was Third Grade and Then EAN Where like to Fit in Sync with Their Six Grade Yeah They're Not Rulon I'm And Some past Minimum Wrestling in Bed before Because I Can't Get Any Risk As I'm in so Much Pain Amount to Different Campaign I'm Fighting in Bed And, and I Asked the Doctor Early about Miracles Mistakes And I'm I'm Telling You since I'm Sitting Here Pam There's a Just Peace Washes over Me and I Was like I Got This Boot You Have To Worry about It Again from That Point on Never Thought about It Again No New That I Just Knew I Was Gonna Survive My Job Was Just to Sit Back and Let the Doctors Do What They Do Just Survive And I Never Had Another Doubt It Was Just Another Doubt When You Go to All Kinds of Different Emotions but at That Point I Can Pinpoint That Particular Night In That Particular Time Lay in My Bed That Just This Piece Just Should Just Watch the So It Was a Journey so Obviously Held That the Doctors There Was Intervention There Was Medicine Use What Was the First Step and Then Going through That Kind of Schedule Well after He Told Me Also Dine Six Months He Says Renders and Chemo Which One Part of the Original Plan And He Says If the Cancer and Get Your First Chemo Might Take You to His Close like in the Death And so Started at about 240 Pounds And Ended up at Hundred and 87 Pounds Not Hear My Head Not Eyebrow Not on Those Here Nothing to My Butt Crack Nothing Great I Got a Great Plus Track Story I'll Tell You What I Think Is Interesting It's like I Can't See Any Hair Appear Honey Get over Here and Check It Check It You Opened It up so I Got a the Story Them so Now They Get You up to Rehab Right and You Get Move in and and Running It through One of My Jobs Was to Get up Just Walked to the Nurses Station and Back And I Got This Walk and I Get This Go We Haven't Got a Nobel Drama so Don't Fall down And His Name's Alex Left That Matters but Some Walking a Little Bit And I Get a Nurse Station Come Back Think of Had a Good Day Chemo Start to Sit in This Is Going on for Several Weeks Now Now I'm Bald In Almost All My Eyebrows Nothing Else, but Record Showed That Just Run the Story Anyway so I'm Plugging along with This Little Walker and I'm Sweat Its Work And so His Squeak Squeak Squeak Is a Bad Food You Gotta Stop The Guy Gets New Tennis Shoes or Something to Those at the Time No Hearings All Messed up And so That Was Just Really Driving Me Crazy so That You Stop It's Not May Misuse Arts Week and That Is Not Me so Just Stop He Stopped and I Don't Squeak We And Alex That You Know It's Not Me Markets Coming Out Of the Words Come from Is Not Me Maybe It's the Walker That Is Not the Walker Alex to Stop so He Lets Go And We Schooley and a Wooden Walker so at This Point I Am Not Weight-Bearing on That, My Right Leg at That Point What It Happened I Had Worked up Just Enough of Us Went up That In My Butt Crack Every Time I Walked He Would Just Go So Now I Go through All This Every Stop Looking around and so Now I Know That Every Time That I Was Going to Rehab I Was in a Walking Pillow Squeaked That's When I Knew That I Had Accomplished My Goal Don't Use Workup Enough to Wash with Sweat Now Get the Squeak Going and It Was Just the Funniest Thing That I Got a Bazillion Just Hilarious Stories Out Of All This Have a Real Serious Situation but There's a There's A Lot Of Humor in It and You Have Some Humor Chair Otherwise You Know the Doctor Really Said If You Don't Have Some A Positive Attitude about Stuff and Support Your Family and I Completely Believe That Because There's so Many Things in Our Brain We Don't Know That the Brain Does Leases or Controls in You Being You Guys Mean the Doctors Will Have All That Knowledge Young at All, Intellectual Me What I'm Trying to Wrap My Brain around Is When Your Brain Said No We Got This What Did Something I Mean There's Epigenetic's Going on When No I Got This Does That Change Something in Your Body That Allows You To Have a Better Chance of Surviving a Cancer That Kills a Mindset Has To Matter Hat on It Months It's Been a Big Think about Using Somebody in the Office in the Head They Walk around Get That Permanent Frown on Her Face No They're Just Negative All the Time and They Got Those of People Walk around or Just Bouncing off the Water Happy and You Can't Tell Why Is That Is That Genetics Is That Something in Your Life Is It Just Your Attitude What Is It Your Your Physical Appearance Turns into What You're Your Attitude Becomes and If a Negative Note That the Frown on My Face Than You Can See the Body Language That Best Personality That You Become so the Survival Piece I Think Is Is A Lot Of It Is Mental and It's a Battle and If You Decide At Some Point I'm Going with This Then You Can Whip It I Can Tell You That Story but I Could Also Mean There Will Be Another Thousand Stories out There the People Didn't Survive How Do You Know I Remember after It Has a Good While after You Finished Everything You Came up with a Slogan I Think You Started to Incorporate Will Get to It Later but It Was Your Getting What You're Getting Because You've Been Giving What You Been Giving Right And That Can Go Back to Your Attitude Really in Anything Right It's That's Funny I Stole This from Zig Ziglar I Wish I Could Say I Invented or Kept It but It Wallace I Was Gonna Let You Float within the 21 When Her Water, Carried My Wife Work Foreman and Brought Home All the Tapes and so on Wasn't to Home and I Thought Just That's Just so Appropriate Because If You Give a Bad Attitude You Can Get a Bad Attitude and Return And I've Just Goofed around in Different Settings Where People Can Get into a Situation Were A Lot Of Negative Gossip Producing All the Nonsense on Social Media and in the Talking Heads in the News and the Media Nowadays You Going to Setting and Thereby Can Be Fixated on a Particular Item Have This Negative Attitude and You Just Bring One Person in There and You Start Lacing in the Loop with a Positive Attitude and You Watch the Whole Dynamics of the Room Change yet and It's Kinda Interesting Just Somebody's in the Coming Change in Attitude and Works the Same Way yet I Just Know Where to Listen or Ask Might so That's a Big Long Name for the Cancer but It's a Type of Bone Cancer but Is It That Is There Any Other Way to Describe It He's Asking If There Is Any Other Way to Scratch I Have yet Forgot What I Thought As I Have Found Art but That Is Any Other Way to Describe That Type of Bone Cancer Mark The Lie We Had a Listener Who Is Written in and Wanted to Know Better That Long Night – GD Differentiated Congress or, Yeah Indeed Differentiated You Can Convert Sarcoma Condo Sarcomas the Common Name for It but Because It's Special The Differentiated Gallic Alec up and I'll Just Text a Link Back to Them through Spiny and yet It's a It's It's Rare It Say There's Really No Other Way to Describe It Other Than You've Got This Cancer That's Crossing over between the Cartilage in the Bone and This Is Forming The Cancer That's Coming to the End of the Pelvis like That The Edges Sounds While I Equate Just Give Us a Rundown and Then of What the Activities What You Had to Do I Know They Had to Do Chemo You Had Your Surgery So Yeah so We Had 19 Our Own Record of Good Story in This So You Know Is Doctors Going for Any Kind of Surgery They Give You the Purple Pen Right Operate on the Right Knee and so As the Patient Number Right Now No Make a Mark on My Knee Right Knee So When You Go and You Don't Screw up and Mark the Light on the Left So the Plastic Surgeon Guy Comes in and He Still Me All That Were Gonna Do And They Were Going to Take 6 Cm Out Of the Middle of My Stomach All the Way down Past My Bellybutton up Got a Whole Brand-New Bellybutton by the Way And There Were No since This Backup Okay and Their Rent Their Creighton Flaps If You Think about Taking a Big Jump Folgers Coffee Cup Put Record Your Pelvis and Pushing It Always through Your Body Everything That Went into That Coffee Cup Ended up in the Trashcan Okay so You Got a Cavity There Now What Are You Going to Do so They Were Taken the 6 Cm Out Of My Lab to Put into This Flap down Here to Keep My Insides from Falling up the Backside These Pointers Right Going Right Drawing and the So I Took That Purple Pen and I Said Dr. Reese Make Sure You Leave Me a Sixpack Abs on My Stomach I've Never Had a Sixpack Abs I Thought That Was the Only Chance I Was Ever to Get It and He Did a Pretty Dang Good Job But The Orthopedic Lady Worked for 15 Hours Straight And in the Plastics Guided a Four Hour Surgery on Same Day on the Same Setting And so 19 Hours Totals, It's Amazing Crazy That Is a Long Surgery Which Is I Mean Just Absolutely Incredible Because A Lot Of Times We Talked about Where Medicine Fails but Certainly You and I Talked about That True I Feel like Medicine Could Be Doing a Better Job For Instance Controlling Diet Right Then We Have That 15 Hours Surgery That Is Incredible This Is Where It's Definitely Succeeding Yes Well You Guys There's a Reason Why They Call It You Practice Medicine Because There Is Little Perfection in It Because You're Operating on Human Body Which Is Imperfect to Begin with Right And so And We Talked a Bit Earlier How Went from from One Dr. Trying to Chase down a Diagnosis and I Feel Fairly Fortunate That Each Doctor Said I've Tried I've Made an Attempt and I'm in Have To Send You to Somebody Else and so I Kept It Referred over and over and over It Might've Been a Frustrating Situation but in Reality the Doctors Practicing What He Knows And's Finally Stops and Says I Think There's Somebody Better To Help with Your Diagnosis or Help Push You down the Track Where You Need to Be so Appreciated That That They Weren't so Egotistical That Said I Got This in the Switch Problem Is in and Sit Me down You the Wrong Path so It Was Kind of a Neat Progression That See How the Physician Community Just They Work Together Come up with Right Diagnosis at the End of the Day So Then What Were the Were There Any Other Foreign Bodies Any Other Animal Parts That Maybe You're Sporting Right Now That Didn't Just Belong to You Well So I Have Somebody Else's Pelvis and Me Okay and I Don't Know Are You Going on Animal Parts but While I'm Here Here about a Man Not Really Sure so the Good the Joke Is That They Were Looking for Similar Pelvis Same Shape Same Size the Telegraph You Know of Cadaver Bone to Bone And the Want to Find Something And They Finally Find It in the Comments Aren't We Can Do Surgery on This Particular Day Now You Don't Have a Whole Lot of Female Orthopedist Right And the Lady That's down at MD Anderson Is a Female And so I Thought That Was a Little Unusual And I in My Day Job I Do with Physicians All over the Country And so That's a Little in Common So I Go to the MD Anderson Website Liquor up And It's Black Lady Which Makes It Even More Uncommon And When You Meet Her You Go Oh My Gosh You Are Perfect for This Job You Are the Right Person She Is a Freak and Ball Buster and She Always Had All These Other Physicians Following Her around Because She Was Kind of a Pioneer in This Particular Type of Procedure so She Had Called And Finally Found the Bone Mrs. Art Room Schedule Surgery for This Particular Day How Does She Do That like Can't Even Begin Looking for a Pelvis It's Going to Fit In a Could Ever There's a Bone Bank And Oh so You – and Then Donate Your Organs and the and This Is up California and This Is Another Funny Story That I'm at a Conference That I Go to Once You're Always with You Guys In All These Vendors Are in the Know in the Exhibit Hall And I'm Talking about My Story It to This One Guy Nieces Where Did You Get Treatment Sit down in Houston in the Engine Just When Did You Do That Is It in July 2010 I Think I Know about You Simply Mean Sidwell My Wife Works at the at the the Bone Donor Place Whatever It Is Where They Freeze All the Stuff and She Was Working Going to Bone after Bone after Bone to Try to Find a Picture When It Was This Size and Had to Go to Houston and Bob Baugh And*The Chief I Was Least Found She Was Looking for Shoes As It Will This You Know Anything about the Person That I Got It from And She Says Yeah 300 Pound Black Lady So I Thought I Got This Black Doctor Working on Me I Got This Black Bone in Me and I'm Have a Soul When I Come out Here You Do Dance Better No I Do Not Either to Help Me up Here But I Forget What Your Original Question Was about Diverted into the Wrong Snow We Were Just Talking My Animal Yeah We Just Just the Different Different Graphs That You You Had to Use Mean Here's Surgery Although It We Already Know That It's Long There's There's a Process to It Is a Process to the Chemo There Was a You Had the Best Attitude but It Was Still Work but I Can Still Remember That the Months and Months of of Watching You Show up Tell Your Kids Athletic Events and Games Try to Pull the Truck As Close As You Could to the Football Field You Said You Could Watch and Participate In Family Activity and Every Time I Stop by to See You He Did All You Could to Smile and I Knew That It Was Difficult But You Made It through… Told and Believe Miracles Mistakes Not I Think I'm a Walking Living Breathing Miracle You Don't Ever Take a Single Day for Granite Because If You Have yet Sit and Think about It for Second Get Your Affairs in Order Get Six Months to Live I Think That Would Change Your Life a Little Bit The Things That You Would Miss Definitely so It Just Enhances Your Attitude There Is a Great Day Rated below When You Got to the End Of Basically Felt Okay We Are in the Clear Now We Are Now Are Counting Months an Hour to Count Years of Mark's Survival Time What Was the Turnaround Said Okay We've We Got to the End of What Were Going to Do with You What Was That Day like and Then How Did You and Susan Then Susan's Wife Is His Wife's Name by the Way Has You and Susan Then Began to Get into the Frame Set of Okay We Are Now Moving on with Our Life Everyday's a Great Day And Then Sending Our Accounting up and Yelled Me to a Year Then Is Alluded to Earlier You Made It to Five Years an Hour Already Little over Seven Right So What Was It like No One Halyards This July Night 19th 98 so I Was off the Year What Was It like to to Get to the End of Whatever Therapy That What's so I Mentioned before I Start out 240 Pounds How Is It Jim at Hundred 87 Pounds Indicator Where We Live They Have This I Didn't Have Any Idea but Had at the Time There's a Service That Would Flock Cancer Patients to and from Houston for Free Guy Would Take Any Money If You Driven to Houston It's Not the Most Scenic Drive from Dallas-Fort Worth to Houston Is, Beating Long to Yeah So He Put You in a Plain Little Private Plane to Fly and Drop You off a Millionaire Take Unicorn Delivery to the Hospital and Then Come and Pick You up When You're Done Instead of Being a Five or 6 Hour Dr. and then up in an hour and 1/2 flight which was Fantastic So to Start the Process I Was in Pretty Good Shape Other Than a King Physically Move Mentally I'm Okay But by the End of the Process Nine Months Later Shriveled Withered Enough That I Can't Physically Get Out Of Their Plane And Susan Had to Call Somebody in Town to Come Pick Me up Physically Pick Me up Put Me in My Car Because I Couldn't Do It Myself And I Member Were Driving Home And Just Exhausted And Grind and Say I Can't Do This Anymore Unfinished and He Said Either the Cancer to Get Your Chemo Going Get You At That Point I Was Done of the Chemo so We Call Them Safe Were Done And so Think with That Tortured You Enough That's Reasonable We Have Got to Finish That Story in the Next Half Hour and Then We'll Talk a Little Bit about That Same Charity That Flies People down to Houston Because Mark Decided His Journey to Lead and Inspire Him to Do Something That Is Really Cool Thank You for Sharing That We Had Movies Get to The This Is the Only 24 Hour Take Anywhere Platforms Dedicated to Food and Fun We're Spoony Our Townhall.com, the Special Counsel's Rush Investigations Walking Fresh Speculation the President from May Pardon Some of Those Charged in the Probe Some of the President's Closest Advisers and GOP Allies Fear the Pardons Could Set off a Political Firestorm The President Preparing to Hit the Road Later Today As White House Correspondent Greg Clugston Explained for the First Time since Being Cleared of Russia Collusion by the Special Counsel the President Goes before Thousands of Supporters at a Michigan Rally This Evening Political Observers Will Be Watching to See How Mr. Trump Addresses the Issue Which Could Be a Preview of How He Uses It Politically during His Reelection Campaign the President Calling for the Resignation of Democrat Congressman Adam Shifts Chair of the House Intelligence Committee on Twitter the President Writes a Shift Spent Two Years Knowingly and Unlawfully Lying and Leaking Mr. Trump Also Talking about the Just a Small Laissez-Faire Writing That the FBI and DOJ to Review the Outrageous SEs Smell like Case the Presidents Blasting Chicago Prosecutors to Drop Charges against Millett Tweets Their Handling of a Quote Outrageous Case Was an Embarrassment He's Calling on the FBI and Justice Department to Investigate Correspondence Argument Johnny Says Mr. Trump Altercation Embarrassment to Our Nation Facebook Being Accused of Housing Discrimination Charge Leveled by the Department of Housing and Urban Development HUD Is Accusing Facebook's Ad Platform of Encouraging Enabling and Causing Housing Discrimination Facebook Recently Vowed to Overhaul Its Ad Targeting Systems to Prevent Discrimination in Housing Credit And Employment Ads a Seattle Bus Driver Being Lauded As a Hero despite Being Shot and Wounded by a Car Jacquard He Still Managed to Drive His Boss with a Dozen Passengers on Board Out Of Harm's Way While Street the Dow up 48 Points More of the Stories at Town Hall.com Take the Pain Out Of Ordering Your Diabetic Testing Supplies with Diet Thrive Diatribe Ships the Testing Supplies You Need Directly to You When You Need Them Best of All with Plans Starting As Low As Eight Dollars a Month Diatribe Is Probably Going to Cost You Less Than What You're Paying Today Diatribe Is so Convinced That You Love Their Service They're Offering Your First Month of Supplies Three Simply Type the Kodak DOC and Checkout Diet Thrive.com That's DIA Thrive.com Have You Done It Did You Catch a Glimpse of Yourself in the Mirror I'm I'm One of Those People You Don't Want to See Naked IBM Most of Us but I Mean You Look and You're Going to Die I Don't Get Whatever All It's Horrible Hey That's Doc Townsend and Brad Staggs to Tell You about a Different Way to Shed Those Pounds This Is Brand-New Technically Been around for a Couple Years or so It Was Based on Research from the University Of California That Said There Is a Molecule Called OEA That's Found Naturally in Your Body Produces It in the Mediterranean Diet That When Taken Concentrated Amounts It Will Actually Make You Feel Fuller and Boost Your Metabolism I Lost about 10 Pounds so Far Is an Amazing Ballet School Company Said We Can Take This to Market to Make This Great Product Will Help You It's Called Reviews on Our IDU Zone.com Our IDU Zone.com Brad's Work Does Were Comrades Work for Me Countless Other People Go to Read You Zone.com and Try Today You're Gonna Love It Read You Zone.com Remember That Our IDU Zone.com Are You Tired of High Cable TV Rates Sign up for Dish Today and Get a $500 Bonus Offer While Supplies Last Loss Locking Your Price for Two Years Guaranteed Call American – Your Dish Authorized Retailer Now 800-570-6630 800-570-6630 – 800-570-6630 Authors Required Critical Negation 20 from Early Termination Fee Any Auto Restrictions Apply Call for And Welcome Back This Is Going to Be the Second Hour Episode Forever Getting Project Here with Your Host Ken Brown I Am Eric Rager Joined Today by Mr. Mark Silliman Will Continue His Story Here in Just a Brief Moment Quick Reminder If You Want to Get Your Daily Polyphenol Fix Pickups and Are Trying to Let Love My Tummy.com/Spoony He's Wearing It All Right Here in so Many I Love That He Just He Just Took off Her Sweatshirt and There It Was Perfect We Are to Get Comments Today so You Go to Get Check Project.com and You'll Take Straight the Page Go to Connect You Can Send Us Messages What Is Really Cool One of the Listeners Said That He Deftly Checked His Ego at the Door so We Call This the Jet Check Project You Really Can't Learn If You Think You Already Know Things so The Ego Is the Biggest Enemy to Learning So We Ask Everybody to Check Their Ego at the Door so We Can Talk about Anything Including Squeaky Butts Squeaky Bats Mark Did That Right off the Bat First Half-Hour Ego No Enzyme No Ego and That One at All No No No Hate Mark so We Are Rounded out the Last Half-Hour You Telling Us That You Had Been at the Point Where You're like I'm Ready to Stop Not Being Able to Get Out Of an Airplane And You Finish It up on That Story Where You Began to Emerge Out Of Therapy and and Post Cancer Treatment Will The Treatment Part Was over Now Just to to Survive So I Go Back Every For a Long Time As Every Month First Year Goes by Course Masking the Chemo Doctor Now Tell Me Statistics Many Survivors Do We Have No Who Else Is like News out There I Get Nothing They Could Be Grim Nothing You Know When I Don't Talk about That Which Have a Good Attitude We Could Move Forward Right So It's Every Month Asking the Same Question Back down Houston Finally Had Your Two Rollaround Same Questions Same Story Give Me the Same Answers Showers and a Great Attitude about Improbable Your Three Rolls around And or the Statistics And He Finally Coughs up That We Gotta Have People You Can Have a Data Backup Patient Right Now We Got a Bunch of Patient Statistically like You Tell Me Where a Man How Many of My Mother Would Get 455 Patients in Our Database And I'm Thinking I Am Not Sure That's a Statistical Analysis Enough of the Sample Size for Statistical Analysis May Be so Mean Spirit Better Than Nothing Sure but That's Only Give Me at That Point so Your Four Rolls around And I'm Beat Them up Again Whether Stats Only People like Me except Her And Get Better and Put on Weight Grumble Her Back The One Closer to Normal Aside from I Don't Have a Groin Muscle and Half of the Hamstring Muscle In Somebody Else's Pelvis and We Can so It… I've Got Some Limitations in the Things That I Physically That I Can Do And Give Many Statistics Year for He Finally Says Will You Are the Only Patient That We Have Had That Hasn't Had a Reoccurrence In the It within Four Years so to Bed Mentioned Earlier That That Then Take out the Tumor but They Don't Know Word or the Genesis of the Cancer So It It Affects All the Rest of Your Organs and He Had Said That And We Just Take out Organs As They Go on to You Can't There's More and We Can't Take out and That's It You Your Done Lights out So He Says You're the Only Case That We Have That Has Had a Reoccurrence of the for Your Mark Five Years Rolled around I Give Him the Same Questions And He's Pretty Excited That Point And He Says You Know I Think I Found the Secret Elixir to Solve This Problem He Lost His Brother to This Type of Cancer so He's, Dedicated His Life to Solving the Problem Whoa And He Says That I Think I Want to Go from 0% Success Rate To 20% So Go Seem the Following Year and How's All That Going Were the Stats Not until Manning and He Says He Is Buried I Don't Use Were Depressed but He's Not It's Jovial and As Happy As He Has Been Because He It's What He's Doing Now What He Did on Me Is Not Working on Other Patients so He Where He Thought He Had Found Some Kind of Cure to Help Some People It Had Worked so at That Point He Said We Still Have Any Documented Survivor And I'm Now at Nine Years of Be Nine Years of Some And so for Lack of And One Was Living There Anybody with This Type of Cancer They Get Funneled to MD Anderson to Take Well It's Rare Enough That I Don't Know That Everybody You Know Can Identify the Particular Type of Cancer and They End up at Anderson Sure You Know That I Feel Fortunate Enough That I Had Doctors That Said Well You Got Something's Kinda Weird Here and I Think You Need to Go on Those Centers of Excellence So My Mom Spent Middle Years Go on the MD Anderson and I Had Experience That in the Care That They Gave You There's so That's First Place I'm Going But There's Other Places in the Country That These Guys These Researchers Shared Information Back and Forth I'm Not Saying That the Dr. Robbie Had 455 Patients of His Own Don't Hate They've Collected This from from Other Clinics or Other Centers of Excellence and Greatest Database and Sharon Research So You Were Patient Number One To Make It to the Five Year Survival Mark and I Did Not See Him in January and Still Go Back Every Year But I Didn't Get Him on the Schedule So the Orthopedic Lady but This December Want to Go Back I Will Make Sure I Have Him on Schedule so I Can Give Him One More Time Right Where the Stats We Also like Me Is There Anybody Else out There That's That Surviving How Are You Doing to Your Cretin The New Elixir Saul Somebody Else's Problem It's Crazy but That's Just like When You Are down to Your Last Dollar You Don't Know How You're Going to Get Out Of the Casino And You Going to Put It on the Table and Hopefully Hit Hard Eight or Something like That so That She Could Buy the The Flight Home That Is Exactly What I Was Thinking throughout the Whole Story Yes They Can Blackjack the Whole Time That's All I Mean That's That's All and Its Outlets Actually It's Craps but so March I Whenever You Talked about the Flights down to Houston This Whole Journey Inspired You to Take up a Completely New Hobby You Still Have Your Other Job Where You Still Deal with the Orthopedists and That's Obviously Something That You've Done Well in Your Own Entrepreneurial Spirit Etc. but You Took up a Completely Different Line of Hobbies And Wanted to Tell Us Little Bit about That Well so the Guy That Runs This Nonprofit Indicator Kept Busting My Chops Marketing Learn How to Fly Needle Half-Life And Off-Line Looks like A Lot Of Fun Theoretically at Coming That Looks, Your Fighter Pilot Doing All That Stuff but When You Actually Watch What They Go through and What They Do and What They Have To Know and Learn I'm the Guy That Wants to Put the Key in the Car and Just Go Right I Don't Know All the Details and All That Other Stuff Is Just One Draft Just Want to Go and Watch Him and All the Stuff That He Does Fine so There's No Way So I Mentioned Earlier That He Wouldn't Take Any of My Money So the Only Way That I Could Give to Him Because What He Gave to Me Didn't You Get Good or Given Which Given I Decided to Volunteer They Do a Charity Bicycle Race Every Year in August a Week or so before Hotter Than Hell And We Have People to Come from All We Had Somebody from Czechoslovakia and Australia with People from All the World That Show up This By Chance And Then End up in Modern Hill in Wichita Falls Which Is Kind of a Cool Ride so These People Arrived in Sandman This Is A Lot Harder And Harder Than Help Is How to Enhance Flat You Have Some Hills to But It's Pretty Good You're Right in the Trees and on the Country and It's a Little Bit Different Anyway so I Volunteer My Time for This Bicycle Rally And of Course He's Given Me the Mark Geller How Fine You Gotta Do All the Stuff in the Next Bobbio He's Cuban But As Names Fob You And We Say Five You Think of Long-Haired Guileless on the Harlequin Romance Books and Stuff up to Another Five Euro Story in a Minute but Anyway so Bobby I'm Not No Money to Do It One of the Ladies That Runs This Kind of Head Pet Dog in Charge of the The Bicycle Really She's a Doctor in Town Jesus: Clients Not like That That's Just Bob You What You Comply with Me and I'll Show You What It's Really like Pilots Live in Decatur It's Not That Big of a City Is Only Five 6000 People Live in Decatur but 74,000 Pilots through the You Think Everybody's Flying Planes Yeah She Gets Me in and Select Jeep Punching the GPS and the Plane Just Takes You There Right Skunk in Your Car except You Gotta Drive Give a Gas and Brake When a Plane You Just We Put in the GPS and It Just Goes I'm Oversimplifying Thi
Chef Patrick joins the show, also serving as producer of GCP for the Spoony Digital Radio station, to discuss the launch of the new show, planning executive chef level meals for large groups, and medical vs restaurant trivia!https://kbmdhealth.comhttps://gutcheckproject.comHey hi Mandy if you don't know me it's probably because I'm not famous but I did start a men's grooming company called Harry's the idea for Harry's came out of a frustrating experience I had buying razor blades most brands were overpriced overdesigned and out of touch and here is our approach is simple here's our secret we make sharp durable blades and sell them at honest prices for as low as two dollars each we care about quality so much that we do some crazy things by world-class German blade factory obsessing over every detail means were confident in offering 100% quality guarantee millions of guys have already made the switch to Harry's so thank you if you're one of them and if you're not we hope you give us a try with the special offer get a Harry starter set with a five blade razor weighted handle shave gel and a travel cover all for just three bucks plus free shipping just go to Harry's.com and enter 5000 at checkout that's Harry's.com code 5000 enjoy and welcome back to the chase project episode number three we are still here and love and we think we can keep doing this to like episode like Joe Rogan episode number 2068 they still let us back on 2068 means only have 2065 the ghetto Jordan close we are getting closer so thank you again for joining us that the feedback is that once awesome it's a it's impressive I had no idea it this many people in such a short amount of time and want to hear what we had to say about bridging the gap between health and nine natural and medical science absolutely I love it we've been as we get to hear shortly is a big message by a bunch of people and had a lot of friends from you know all over the United States contact us and say hey that was that was interesting is recovering some cool stuff special last week with Sean Brian's on if you did not check it out please deep dive into CBD and a little bit into the cannabis industry but really cool such a deep dive that the material was so informative that YouTube of course allowed us to keep spreading the message but Facebook will hold our our recording down for little while we had replaced it with YouTube so I guess if you want to know the truth then sometimes I suppose, slow down a little bit about the debts and we covered those topics like they obviously did that because of the particular topic that were time as we are all about the science of it where showing everything that's working to do really continue to do this and today what could we have our show today we are going to be joined by Chef Patrick Mosher now if you listen to the spoony network already chef Patrick Mosher is already somebody they are quite familiar with however get experience from all different aspects of cooking for gigantic hotels being a part owner of some large chains and putting together the food items ever essentially he's he knows how to build food and how to make something out of his message is you are what you eat my messages all health begins and ends in the gut this is why teaming up with chefs and getting out those can be supercool thrilled to have him is actually the producer of our show so this is going to be any reason to tune in to be that were to move him over here and easier to be a guest so we had to on the fly he had to on-the-fly teach Eric's wife Marie to run the to the production desk over there so if anything let's just stay tuned for that because as a camera isn't where it's supposed to be don't be mad at her doing what she did she just learn how to do it two seconds ago hey you can't blame her for me setting the camera incorrectly can't blame her yelling at the right way that are really fun though regardless speaking of let's get caught up on our on our recent week weekends anything big happened with with you and your families last week it's pretty chill something conical I just mentioned a little bit about how people been messaging us now remember we are the gut check project I phrases check your ego at the door everything is on the table and somebody had messaged me on Instagram and asked why do we what was to get your project Y check your ego at the door and only last week was actually my birthday on our show and I I read a book written by Ryan Holliday called the daily Stoic all this is a fun little way to start your day by those every single day he takes a lesson from a Stoic philosopher McKenna dumbs it down and gets it through okay so March 14 was one that I had I thought it was way too coincidental that somebody message me for this and this was the actual thing so bear with me while I explain this but it makes total sense to me and this is the kind of stuff I start my day with so the quote is from DRG this layer to this Zeno would also say that nothing is more hostile to a firm grasp on knowledge than self-deception so what I like about it Reinhold he then breaks it down basically says self-deception delusions of grandeur these aren't just annoying personality traits ego is more than just offputting and obnoxious instead it is the sworn enemy of our ability to learn and grow as Epictetus said it it is impossible for a person to begin to learn what he thinks he already knows today we will be unable to improve unable to learn unable to earn the respect of others if we think were already perfect and a genius admitting it so that was the philosophy that you and I have ordered set up the show it's got check project check your ego at the door sitdown and let's learn from each other let's teach each other and that's why we have a chef on today is regularly about food right we deftly learn little about food you well it's good question so I speaking to my wife who is going to work in Camas today for a show thank you Marie this this last weekend we spent our time with my boys putting down a new floor on the chicken coop so alive has had experience in the past we've had her own chickens and we harvest on eggs is the best tasting as you can possibly imagine but if you like spending around 72 $73 and egg get yourself some chicken because it's awesome they taste terrific buddy on the great that reminds me because I do believe that you guys tried some beekeeping at one time you and I put together what we've taken care of carob some patients which I'm sure that be okay with me saying that that they were beekeepers so there was a Dr. Robert Bender was a gynecologist in town unfortunately died of cancer but it was the funniest thing having lunch with him and he thought about how him and his wife decide to get into making honey results fantastic to goes I'm a gynecologist I know how to deal with women I sent you will treat one queen really good and I get all this honey and were selling this honey its local natural honey it's $7.60 a bottle only cost me 28 per bottle exactly what you say and I love that guide I love the quote unfortunately always best on book I like it when people take risks like that kind of owner will completely own it, check your ego at the door to tell you that were having fun doing it were not making money the farm fresh eggs taste great we just got to get to the point where we don't have our dogs take chicken that's others to hate the originals you mentioned a book and some is really cool/we even reading this book from Isabella Wentz ideas yes you and I both receive this fantastic book Isabella Wentz is an amazing PhD once you haveso can I fortunately meant to admit Isabel and her husband's a year and 1/2 ago when were working in San Diego and she was diagnosed Hashimoto's and dad she then asked she was diagnosed with Hashimoto she went on to change her diet laminate some of her triggers trigger foods like gluten and dairy containing foods and then began to find that she could eliminate out that inflammation and put herself on a road to recovery it's not any different than what you wrote out what you have the Stoics book the reason was to get to project what dad Dr. RI what does chef Patrick's going to join us and talk about how you can control how you feel with great food it's no different so thank you very much Isabella for Isabella and your husband's name but will find that out and thanks so much for sending us the book W read this to recommend it to my patients you done an amazing job oh yeah Hashimoto's food pharmacology food pharmacology comes with a full meal plan at the very back with all the way down to what exactly what to buy inmates like any other recipe book but it's it's high quality tell you why why you're doing what you're doing not just eat this for here's what will do will all of them will all read come back into her like a sort of synopsis of the book once again as well thank you so much for doing that supersmart woman love talking to her when we were in San Diego with my insurer meeting that was awesome definitely absolutely season quick catch up for listening here on spoony don't forget if you want to drop by and pick up some love my tummy.com/spoony for your own are trying to heal you get a discount for using spinning is the discount code as well as check out KB MD health get your brand-new KB MD CBD in our new store so if any of you have ever read Isabella Wentz's books or if you enjoy the show at all we are all transported to other this is a rising tide will lift all ships one way to do that is to actually go to these websites purchase a product and use those codes so that everyone is trying to help each other out we want to make sure that Chef Patrick has a successful show and his network grows in the spoony radio digital platform becomes massive and one way to do it is definitely going on and supporting our sponsors without question without question will get moving here when our first half-hour and dad, the format is that we touch on health matters as they come through KB MD health was to talk about here the gut check project so can want you tell us a little bit about what is on your mind healthwise today so one of the things I mean I'm a complete nerd so you want to geek out at some point in the show and I was thinking of the articles I but I basically spent my nose in journals all day long and starts trying figure stuff out but then I came across this really cool article about the science of food and it just falls perfectly into this Hashimoto's food pharmacology and were to have Chef Patrick on here so no food is fascinating why do we like it does so many things you've got texture you've got smell you taste the consistency of it there is a whole science cold food pairing Scientology porcine science science and science technology and technology articles food pairing technology Where you look at this and you can actually manipulate which we like for instance one of the examples were the more simple examples would be like when you eat really fatty meal ribeye right will the lubrication that happens on your tongue if you do too much of it you can balance that out with an astringent thing that actually binds to proteins and gets rid of that slimy field okay so it's the balance you don't want too much of anything guess what is very stringent read one that's how come red wine pairs so well with a good adding ribeye has and an actor just get that to go away so I started going down this route a whole family's articles and I'm sure that this is second nature to the chefs out there and the other golf course that is but this work is really fun as it turns out only 20% of your taste is actually happening on your tongue okay 80% is the aroma and it's the aroma the terms on everything else so the we perceive the aromas because they interact with our olfactory nerves so as it turns out these different aromas do different things and you can augment them we talked about the entourage effect last week you can actually have an entourage effect when it comes to food by pairing certain foods that have chemically similar aroma molecules okay so in and before you do for my taking a sip of this be similar you said that you would use an astringent to basically cleanse your mouth it's really probably no different than using I'm guessing Ginger whenever you're about to eat sushi so the ginger works like that exactly so as it turns out like for instance did you know that like white chocolate and caviar go very well together did not it's wild because when you put it through when you take these foods and what the scientists are doing is they're taking the foods and they're putting it into a gas chromatograph okay and what that is is that is something that actually shows the molecular weight you can go out here despite your spike these two foods share similar spikes as it turns out white chocolate and caviar share similar spikes in that molecule is trimethyl Ammon Miriam smells like fish sure does in fact there's a disease on the side note: try methyl or I'm sorry it's try meth alanine is the molecule trimethyl and manure is one that I'm familiar with is I've actually had patients come to me and like it's weird when I eat certain foods people can't be around me there like you have a weird odor that's called trimethyl Avenue area and it's that molecule which is trimethyl M and trimethyl amine certain people have a genetic predisposition with the Caprica and I looked at them going to do anybody receipts in a like for like yeah and Mike got in all we do is change your diet problems gone yet so I could you start looking at some of the stuff in the science behind it is so cool when you're looking at the interactions what can happen is that you can have similar molecules that paying your olfactory nerve to go to your brain and go oh that's this and then if another food pairing pink that same one a little bit a little more little less so on then it heightens the first one so you can build your recipes and food off of the molecular structure and beyond the whole tongue thing you know the sweet salt bitter sour mommy the new one the earthy flavor of this is the way to really take your food to the next level and much of what chefs have probably learned Michelin star rated shaft is there already doing it without realizing that it could be based on the science of this church so for instance like a large portion of a strawberry actually has cheesy molecules really so you can sit there and pair strawberries with a certain cheese and it will augment each other the they will build each other up so really fun I never would've thought about this checking my ego at the door I start going down food science because we got a chef on the show today and then this opened up the whole thing right on the UK website now just real quick it would just be any kind she's surely has to be you would make strawberry nachos I'm just saying I can a case on top of the pile strawberries no no it has to be certain she's with similar molecules okay that have this yet and so you can go to food pairing.com and my kids are having some fun with this today where you can create a recipe so I so I looked out to Chef Patrick give me a protein anything you want give me some food product or to build a recipe offer right now live let's go with duck duck so this done whereas I specifically duck breast reason to start with this not a malady yeah okay would you like to be wild yes okay wild now will begin to do is somebody has put a duck breast into a gas chromatograph and they have figured out how to actually pay the so now foods that are similar or foods that have a molecular component that is similar include all kinds of different stuff but basically here we go I think that you should pair this with as it turns out Remi Martin cognac that's why he had his first thinking online CLE source any serious interest in their honor will find out right here what we put a citrus solicitors one day before he answers Patrick what kind of citrus would you would you already kind of will intuitively think it will because he thinks something is sweet yet astringent like can I do colorize right so you have this rich duck in and it's not just a fat ass again okay accommodation all the flavors some curious if if the classic pairing in particular is one that comes up one would match okay and also so fun about this is that now or build it so I an interesting fruit that you showed up as persimmon oh so will add that one so now it's happenings were build missile recipes so you can decide how you do this so we have the ability now to realize okay why do certain foods taste good so my son Lucas and I were talking others were having fun today looking at this and he goes wait a minute is this a way to prepare foods so that the healthier foods will seem like they taste better take so like I want to put tail and do something else with that and I'm a parent with something that'll augment the cheesy flavor of something else use less of that more of the tail they help each other out like this facet of never ever ever heard of using food pairings through molecular studies to possibly trick your brain into liking the food more making healthy food more appetizing making healthy food more appetizing as well yeah interesting yeah so just come and follow things left my nerdy clip of the of the of the show youngest and hours on there now you just ruined her life anyway though I am so what you can do is you can actually Savior food parents and my kids were doing this also and my daughter Carla built a 40 or 50 when we look at it here she started with C Urchin okay branched out and we've got all kinds of stuff see urgent tied to cow mozzarella which eventually takes us to buckwheat and you can just see how much fun this could be were you could do this and it's it's based off the realm of what I loved about what Lucas said was let's make healthy food tastier sure and do it like this sure a lot of chefs probably know this but this is a way to actually use this as this is the style that I would do when I have the Hashimoto's food pharmacology going on to make it taste a little better as a way to do nano kid let's answer bets and brilliant tool that I had never been exposed to Alec some of the idea that foods could make you smell all the different onions for instance I may not love onions but if not grilled in your eating fresh onions it's MS your partner is also eating onions it sets, no go right you and I had a discussion on and I wanted to rail us off of of building that the foods to make them taste better but wasn't that long ago you and I had a discussion about what asparagus does to urine and you said that somebody was doing a test whenever I believe you are in med school that they were basically trying to figure out how fast somebody could rapidly make the the year and change its odor from consuming disparaging of that conversation is absolutely so back in the day this during my fellowship Dr. Wessler was the was a pioneering guesser elegy he's the guy that figured out that there is such a thing as lactose intolerance and we say that like it's nothing but somebody had to figure out that there's an enzyme called lactase and so he was as it as a scientist and document it was kind of fun because he would give us a lecture every year and the fantastic guy is in his 70s just kinda having fun with us each a part-time no part-time lecturer and it would be the same lectures would be lovely pictures from like the 70s it's awesome he made everybody eat a bowl of asparagus and then they had to go P and never really had the time when they could spell when they could smell the asparagus is because that was his absorption study which are not only do away with that now ribs like you ever eat this brilliant. We started smelling yeah yeah the take away whenever you were doing that they were stressing how quickly it happened to break down the food I was really quickly in these molecules that do this – get in your bloodstream and get filtered through your and some of them remarkably quick so what do we handle distribute on about onions when people take Allison which is a garlic extract that they will actually use the garlic out of their breath out of everything because it just gets absorbed so much and that's one of the issues that my patients will have in the company will be taking supplements be like something's wrong Mark are you and Allison like yeah Mike I could smell it from here well if you happen to watch the gut check project and you want us to have the ability to tackle a new subject the best thing to do is go to KB MD health.com escaping the health.com go to the gut check project show you'll find that there is the ability to connect with us and submit something he wants to tackle that's really how we the last two weeks we stumble across what we've always come across to talk about we cover so much ground he only would it be really cool we were talking last week about bringing Dr. Blair on Col. Blair onward and talk about TBI right now imagine doing the product light on the hospital's trauma hospital we have a food protocol for traumatic brain injury we don't have CBD protocol with DHEA or any that stuff when the beat amazing week ago were going to be a brain information diet your to be on the supplements and this is the protocols can happen that's the goal of this whole thing is to bring science and I mean a whole separate show would be talking about so fewer of thing which is a molecule and cruciferous vegetables like broccoli was it turns out it's really really good for you it's anticancer it's anti-inflammatory but when you cook it the enzyme can't break it down called the Rawson Ace and so like a little hack would be a chef we can sit there and say no were to put some of mustard seed powder on it and then it will actually convert it so you just made your broccoli or broccoli sprouts way healthier sure so if you ever get diagnosed with cancer and there's all these crazy studies about like bladder cancer and stuff like that when you do that like I would love to have a protocol food protocol what you're gonna do the Hashimoto's food protocols right there working have a food protocol if you get this venture headed that way no joke on the Chrysippus vegetables they come with them basically so you're blocking the estrogen correct correct yeah not separate magical inane speaking of preservice vegetables B cauliflower just last night my wife and I went to go eat pizza awesome pizzeria and actually make gluten-free pizza the crust was made out of cauliflower it's amazing what they're doing cauliflower now because it taste like great bread and is not read it all basically having a great Chris Arafat's vegetable while you're eating a delicious pizza and were hoping that in spray glyphosate on it so that it's a good skill LOL yeah non-GMO vegetable crust they taste just like regular bread is real know I love all of those cauliflower crust so it is delicious so we've got about half a minute here before she attaches going to join us in the next half hour just a quick reminder if you are watching spinning network EA know if you haven't you read to be sure and check it out there is also the no-show is hosted by Alisa Shakespeare Alicia Shakespeare and her name her shows no butts to big snow but stupid' TS is too big to get out it's a great show and we will join you in the next half-hour dry don't ill make you feel really good about yourself doing something good for somebody else if you'd like to do that today J DRF.org join them in the fight against type I diabetes J DRF.org it's something good you can do for the world.org hey guys Matlock the conservative cartel I like to take a minute and tell you about a new weight loss product that's instantly becoming part of the mojo 50 family it was launched by a Dallas area company when taken the good stuff and olive oil created a patented product that helps people control their appetite and lose weight 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dish authorized retailer now 800-570-6630 800-570-6630 – 800-570-6630 offers required critical location 20 from early termination fee any auto vein restrictions apply call for hi it's Doc Thompson for Matthew 25 ministries Matthew 25 ministries is one of the few charities all actually endorsed because I know them I've worked with him and I know almost all the money that you donate goes to help people go to M2 5M.org M to 5M.org and welcome back to the project this is GCP and Mayor Gregor joined by your host Dr. Ken Brown what is up check your ego at the door let's learn some stuff hey guess what we have now our second ever guest our third ever show so we figured it out third ever show you never say never guess we are joined to my right the man the myth the legend Chef Patrick Mosher hey don't you know that's that's quite an intro not sure I can live up to you lots not bad for sending DUI if you live in an Iraq chef Patrick does a lot of everything is chef obviously he also produces many the programs here on spoon radio he drives fast he texts and drives he doesn't sleep he likes his smile he likes to laugh Emily now I only text voice text almost and I just use a series command so if it comes in a garbled and funny blame Siri yeah well I just made it up at any another string I like you I drive lightning I got around on the weekends between here and there for work in any other time off I have so like the real work so doctors are unique persons are they have unique personalities I chefs are I think they take the cake and fruit upon the intended I've met a lot of chefs and a lot of sepsis patients and I am just fascinated by that lifestyle that you don't thank you so much for coming on we talked earlier about how Isabella went send us her book and last hour talk about how food is you are what you eat all health begins and ends in the gut and here we are we've got a chef with some serious experience you have you have done a lot if you think you and I worked at been fortunate to work all over the world I asked you can start my culinary career in Japan well as I started my culinary career career in a Sizzler steakhouse when I was like 14 what what kind scissors Western Sizzler is yearly wishes Sizzler stay cast so Sizzler was a pretty big Chad pretty chain back in the 80s and early 90s her hand so I would see I was the busboy dishwasher at the scissor state has until Thursday night came around I got Says that as a dishwasher busboy and apparently on Thursdays there is all you keep popcorn shrimp so the kitchen as he was like okay cool I'll cook so I was Sam's bussing outback that he can put 10 piece shrimp on any given play because it's all you can eat right there Arizona State football team and command after he simply teachers that your back in your ear like helping other iron in their back there, laughing at you because they get your percentage of your tips not only do the hardest job is to clean the fire at the end of the night but they get your money it only took me at six weeks to figure that out here and I was like man I'm the dumbest guy in the planet and and shrimp everywhere feared you yeah you know what's it's interesting that my first job in the kitchen sent me home smelling like seafood because leaders are progressing to see Sheehan seafood specifically every night was like a gate getting came to bed before he took a shower because your sheets are just a mistake in his previous but it is what is your family was your family a frequenter of the Sizzler growing up yes we reduces her in Omaha Nebraska so the salad bar limits telephone the logic of that was just going there my favorite item there as a kid was that not any part of the salad that the canned chocolate pudding for whatever reason quite nutritious goes right alongside the square chicken fried steak so this is what I love me with with your culinary chops that has gone all the way to Japan to learn this is where you start is frying shrimp and it says look I lasted about two weeks at McDonald's for that but I don't really count that right now I have nobody ever does now I was acquitted sure what I should do to food my father had a large garden but we lived in upstate New York and the town of Carinthia Corinth if you live there it's near Saratoga Springs Albany that area coming in the middle of steak and damn mind my dad's entire family all of his siblings except one brother lived it within a mile of each other on the same road and my grandfather owns a few sections of land on either side he had a dairy farm and then a large vegetable garden and my father attended at least an acre garden every year so we spent summers as I was like three on the pic means you're picking beans and snapping beans and helping mom put stuff in jar so she could cannon like a cat I am not sure I tell my first culinary job as a real job in the family right up your alley just doesn't work out well my grandfather's letter to cattle every winter and then we split the meat up but amongst the family charities usually did two more later but early in the winter the first big heavy snowfall made at and C have to string them the absolute peace how you gently say you killed him he just killed the bank and then… Our first episode we are to explain my background were Eric would go with his dad to register you and I would go to the slaughter house and my dad was a running neck and since that's what you're saying that let me know know it's not actually it's more like the ad that gasped AGI part O… Depart this maybe maybe maybe I missed my calling but before they can ask to get the animal there something has to be done so they hang it up upside down you have to climb up a ladder and you have to I was five years old when I was taught this my first time you to cut around the muscle up around of the maintenance and yet the tide because if you don't when the stomach elongates it's a geyser oh comes at the back is so that was my first real job for the family in slaughtering B was I got to climb the ladder and hi Taft about who I now I am I much rather have a mean as more or less permanent constipation makes total sense what you were drawing you like him to know where you already you know why writing for lent for several years plus the cost so after you had the exposure to the dairy farm and all the vegetables then that obviously is setting a foundation for you to get into food you probably had no idea that's where your leaning but i know i did and i really my mother was a great cut my father was a good cook a very good cook and her whole family every every that revolved around food okay so as i got my father died very young i was six years old he died to great cancer at 47 while yes and dad back then there was no really no treatment by the time they figured out why you had back pain is been much over and anyway so but i spent a lot of time when my mother cooking after that – i just i just picked up i really love food i did i i was fortunate enough to move to germany my senior year in high school and the family that that that i lived with that hosted me was very generous in that we had to get other countries in and dine on some fantastic food and food as a way of life for them and in germany is where i learned about minimalism in the covered you know because they have dorm style refrigerators don't have baked refrigerators are slightly larger than little boxes you have in your dormitory in the shop every day every single day at least once a day to shop as it was for your bracket was delivered in the morning fresh while that's pretty interesting. it was awesome so i just a side note growing up and watching my grandmother cook my dad's mom she was she was fantastic i loved her fried chicken as she fried a lot of stuff but for some reason back then she still remained skinny but she and i don't know if your mom or your dad was like this my grandmother could flavor anything to taste terrific fried chicken chicken fried steak vegetables etc. but one of her trademarks was to always cook with a cigarette hanging out of her lip that was flavored building with burn ashes in there as well as i think that she saved all the different kinds of meats that she brought in the oil and in different folders cans fish oil and that chicken grease etc. is it something that you also did not say new york yeah you don't weld eventually i think had a different flavor and if it will will start thereby produce because we have burn pile of year trees that would fall with a lot of property and we burn on the actual garden so what would and might my father would rotate back and forth into plots so each season the previous year's burn pile become the new garden in city dias content right the potash well – content was really high so a lot of minerals and i mean it's it's amazing how healthy the vegetables are when you do that you people used to take the ashes from the fireplace and put them into the burn pile into their compost deep sure we don't anymore but that is not right there was just fantastic for the flavor and the freshness of vegetables but my money as she skewed everything okay you accept what you call it swiss steak was boiled whatever lien beef steak she could buy it was the cheapest cut with a bone in it and smothered in them tomatoes and garlic and then she broil that the oven it was actually pretty good – he sounds delicious compared to what were some of the first part of the show what i'm thinking is that you know smoking has a lot of it is a carcinogen known as benzene but we should do is see the chemical structure similar to benzene to add that good childhood flavor that you're missing the smoke when without getting the cancer yeah yeah probably so he can get you can put winston cigarettes into the mass spectra shouldn't even pops out to charge me figure out figure out what fruit or vegetable has a similar molecular component near benzene time answer i'm interested that i'm really curious about that this is a fascinating science for me and i'm thinking i could just as i could change my restaurant consulting business to just be menu consulting based on this and take the elevator TOoh yeah absolutely this is the kind of stuff and we wouldn't be talking about if we were preparing for the show i was just i was just a deal try to think of okay what's a really cool thing we talk about i have to sciences up i like it i'm a nerd and i'll probably try do this with every single topic that we do find something that yes really fun oh terrible that would be really cool so you're sitting there sobbing for your dispose of this great organic before organic was cool you guys had a mechanically warm touch poor poor alright so what happened after that we moved arizona which was a whole different thing i learned about spicy spicy foods right my first meal out in every week and eat out a lot as a child very rarely maybe once or twice a year at the most we went to this little mexican restaurant between chandler and gilbert arizona which are now massive towns that have grown together but then they were just very small towns and that limit its cost is something this little mexican place and i had a chimichanga's mother eating spicy green chili salsa and i went ballistic it was it was done i was never anything but eat tasty food again and and and and not healthy necessarily but flavorful food and that that cannabis bondholder you and you live down there is i guess i was in sixth grade summer and allowing a nice set of a few years so then you you progress through graduate and then you end up oil before you graduate you worked the sizzler and then how did you decide that food beyond being told they arraigned a danger going to do popcorn shrimp something you want to pursue and deliver to people to make him happy what i had few other jobs cooking after that but what i realized is that no matter how how cash strapped your family might be there is always food in the restaurant and she works there used to get some of it for free sure so i think that was it i think mentally i determined never be hungry again right and i just parlayed into into a career but i really and start cooking full-time jobs in japan is working as an interpreter such working as a copywriter start get some interpret good job in japan like writer i did for chemical trans tech international they were a check technical translation company the parents of a friend of mine had come to united states to go to school in eighth grade and stayed all the way through high school they owned and ran the company in osaka japan and he invited me to come and work for them after while i was acting in college time well so i heard you speak german and you also speak japanese type hello, so wow so this is fascinating so chefs or super intelligent people that know i'm serious. many of my friends are chefs or people of extremes share the nar that is fascinating you speak japanese german english to work and back doing appetizer version and it was as fascinating i love you and japanese chefs are so meticulous they have the waiting approach for japan and she had a proverb that defines through japan and it's it's it's that the only the audience at is actually it's it's not just food it's the food it is the substance of the universe right so their philosophy is let it let little seem like much as long as it is fresh and beautiful let little seem like much, as long as it is fresh and beautiful so small portions very ornate and well garnished very clean and seasonal seasonal is the key word there and typically local all just too far ahead but i do remember one of our previous conversations you did say that you were with the noble as well greg i did work for number for number years i actually i was the executive chef and that helped open a restaurant in aspen last month he said that's his last name and then i was fortunate similar location so in a minute i'll imagine all those principles that you're talking about probably carried over to the live presentation the food yeah you know honeywell there's a whole another layer there and he he lived and worked in peru for a long time and he was fascinated by french cooking techniques so he took these japanese base ingredients added the layer of the like infuse the flavors of's of peru and chile and then to add that to another level by using french cooking techniques and just phenomenal stuff while yelling at ocean would say there so my family were huge asian cuisine fans all of it our favorite restaurant is actually japanese restaurant in plano we go there at least once a week really i mean you can send him a plug – or llama iam a check now yeah we have the it's just unbelievable it's it's it's it's good and sensitive i think is very very traditional japanese food had told me our waitress is always our waitress so we just sit around and through to start showing up that's what i love the methodical just this is what's happening it is predictable it is well and it's thoughtful thoughtful yes so it here's a really interesting cultural thing from japan is a great book called mino because with some the dip the anatomy of interdependency okay okay describes her whole culture one of things in japan and when you start a sentence they finish it for you like ice to teach for this guy jenna ricci he had two small children i spoke in my itouch spoken english i taught them english and japanese speaking is my second day speaking with so gimme a break he would call in and he would say i think you and i say yes he is jonah lychee desiccated and will mean this is generally key and he just stopped and i'm supposed to finish since you must be calling about but i wish i didn't know that right some just like okay hi i just wait for him to say something but eventually you learn it's like him japanese interject a lot they say hi a so they stay in there what they're doing is they might say yes oh is not so there interjecting to let you know there listening actively listening even if they say something in agreement it does mean they agree okay i mean yeah but anyway back to the point i was making is when somebody hurts a guest and some house for the first time in you they say would you like some coffee and you say yes they don't ask you how you want to and they don't bring you the things to put cream and sugar in it they automatically put in cream and sugar because the first time as a guest in their house you should not have to think about how you want your coffee served from then on you can just make your own but the date alleviate the pressure from you even if he didn't want it that way and you accept it graciously because that's the generosity they're getting you to relieve you of the pressure of having to say would you please fix it this way oh wow cool yeah there's so many layers of complexity to japan's culture that's all that's a month that well that's a whole series of shows for next year while even a chef for a long time what would be something that in the year in the realm of being a master chef going from the being taught japanese in the office it was some french i carryover what what take your take you to your favorite style of the play setting now i thinks my love simplicity and food such il might my mother she stupid a lot of things but were really great fresh ingredients if it wasn't steered my father was a big fisher and fishman and hunter and so we had a lot of wild game he had we always had a ton of venison backstrap a lot of rabbits a lot of fish so everything is very simple when we went camping my father did take stuff for dinner he would hunted or efficient while a fish will also describe the pressure then a joke yeah yeah tv show now yesterday i really afraid survive as their grills at this time you shop for breakfast but you a loser it was very simple food so you take out lemons potatoes salt pepper and onion and so if if you cut trout then he to be slice of the potato and onion stuff inside with a couple of wedges lemon slices lemon salt-and-pepper and then wrap it will a pat of butter there wrapped up in tinfoil turn on the fire you know if there is other game to be had than it was you super simple or boiled potatoes and simple fixings and then salt-and-pepper on one of the game and so these really clean simple flavors for me i really would identify with any candidate that you can't really elevate that sure with a few adjustments but really being able to identify the main component like the center of the play item the protein if you can't taste what it's supposed to taste like i'm not sure what the point is sure will will today you just unit of joining us because you had just left a gigantic gathering that you are asked to basically help map out how do you know whenever you have so many mouths to feed that you know i'm going to be able to put together this coming plate to serve this this type of convention or do they give you parameters of what they do and don't want hello hello yeah so i'm to make so many development or menu yeah menu development or menu selection for any large parties very very critical because you have to think about if you have have multiple selections especially then what is the em what is the time to plate each item on a plated is his buffet mean all that comes into play i've done parties as large as 2100 people we get i work for a company in houston and we get a large plated dinner for the md anderson cancer research center answer hospital is so wheat we did 2100 people seated but the preparation for that took a week but nothing is really cooked until needed some things are made today before but not cooked until that day but all the proteins like all the tenderloins all the seabass so there are 1100 pieces seabass and 1400 piece of tenderloin while the kennels were hole we had to cut them i i had cut the measure but yeah that's that was we we all that gets cooked in ovens lined out inside of this big giant makeshift kitchen that's 20,000 ft.² and then we had 16 ovens in there like big commercial ovens do you feel like that your principles and how you wanted to live you want to deliver good health for people through the way that they eat that sometimes you get compromised because it gets so big yeah i mean hat so there are ways to dragon simplicity is number one pitcher and then limiting your your menu to items that fit your your desires and what you want to give to people and bring people in the hospitality industry you can't compromise that so only serving things that you may look for an alternate approaching so if they couldn't afford the that tenderloin we could do something like baseball saker you know tri-tip or something like that site to get a similar quality product just not as expensive i think that's that's part of the creativity that chefs have to work with nowadays is planning for and like an upcoming season we change menus to the four times a year restaurants so you're primarily doing this right now for your work also i do that yeah i mean ii will this is your this is my baby i want to get into that as this is how did you end up here doing a digital show but friend will talk about sorry love you so much anyway but the planning phase is really what it is yet to be very organized and there's a science to you know how many pieces everything you need what the portion sizes and what your standard batch size recipe see to scale that up although there can be complications or because salt doesn't scale directly other some other components like oil don't care they don't scale you know it's not exponential it's not like six times this equals that know if the scale somethings back and skipping some something so what i love about this is that you're talking zach the kind of leads into the first part of the show but this is how i cook i view it more as a science and i want to know what this and you're like i don't i didn't have a grandmother with a marble light in her mouth inside yeah so like now at the stage like i have a really i really enjoy quickbooks us all so excited that isabella went something cookbook i got bobby flay's cookbook which is that one on the quick side note is that the ill be like now add the sausage you like got it and then you turn to page 20 like that sauce is 50 and so there is a very famous book book called the the reese's gag gastronomy great and and there's another one by written by august escoffier who who really founded modern french cuisine right in the way that they cooking french kitchens and what happens it'll say like a cookie was a shock which is its sea scallops with marty athos or something right when he says cc the scalp recipe and it says okay now seat recipes 42 918 when you go to the buyer the year but is like 97 steps and then you have the mornay sauce is like when yeah whatever whatever size you are making is like 467 steps and you can't make it you can't story cold as beheld hot and fresh i mean it's just it's so complicated i was like okay that was go back on the shelf and maybe never adult ever dust the back off again i read it religiously 1000 cal you have a terrible cook and sometimes whenever i want to cook and i'm learning to tip these says certain things together if i see that there's a whole another mess of steps to make one ingredient i usually light which is not have any this it's it's changing out the menu the item is off the menu are going to do something well and that's part of the so i'll say on the show sometimes i don't i don't do show prep well i crept much better for life in restaurants than i do life on the radio sure and sometimes i get half with your essay like this make sense now that in the night so i spent a minute research demo i did next he read the recipe i just assume that this is what they meant because this is the type recipe so pre-reading the recipe knowing the ingredients in the methodology they're coming up are really important during the prep work will before we end up rounding out the last is our since you are one of the main producers for the spoony digital radio station we will get to why you ended up joining spoony radio etc. but tell us little bit about some of the other shows that i can and i are just now joining cemented lisa shakespeare she she actually has a her show no butts to big is phenomenal she's very energetically young lady but she had some health issues and she owns a company called total cluster fudge which is not so there's another new and called some monkey butts but that one is is the healthy version of the desert she does now for total cluster fudge and as this dessert manufactures she had to stop eating the things that she makes in the said these are carried in them convenience stores and cosco and there sold over the internet and at some restaurant seasons well which which is great she touched details each watching three healthy tips and tricks to just we held your life every day and along those lines is gwen rich of the rich solution solution yeah she's just stage iv cancer for the last 6 1/2 years she's why she looked way past her expiration date as she and her husband adam say that she was misdiagnosed for eight years before that so she gives tips on eating mortgage with more nutritional value more healthful and how to if you have been diagnosed how to prevent being diagnosed as best as possible that's the very first show i did with dr. thompson you rest his soul you are supposed to sit on my show he's an undertaking to get here early and you shall prep well i love this didn't really into it like that we can do so we can include the chemistry can say how do we make these things healthier like increase yourself you are paying and stuff like that euro lutherans all these big words that basically you can eat well and you're really healthy why don't i mean we have room for play marsh joseph you want to collaborate that were ready to go yet get so we have you have a minute here for you to wrap this this part up so if you're watching now stay tuned you can always check out love my tummy.com/spooning to pick up electron teal caving de health.com he can pick up your kb md cbd next half-hour going to talk to shift patrick little bit more about not just what is done as a chef or what brought them to spoony that also you also required to experience with cbd chef patrick and told us stories night shift well you know this is the only 24 hour take anywhere platforms dedicated to food and fun we're spoony this hour from townhall.com, the fbi joining a criminal investigation of the faa certification process for the boeing 737 max a jetliner the blazer crash since october killing more than 300 people there are a number of inquiries getting underway including one by the transportation department inspector general and another investigation by congress in the wake of the mosque shootings new zealand's government banning military style semiautomatic firearms in high-capacity magazine prime minister jacinda arter and says additional gun control measures in the pipeline's motor began entrance to look at issues around licensing issues around registration issues around storage there are a range of either an image that we believed to need to be night and it will be the second tranche of reforms yet to come following a visit to ohio today vice president from in michigan in grand rapids tonight the president will address supporters at a make america great again political rally's trip to west michigan follows a daytrip to politically important ohio yesterday where he reminded factory workers about the economic gains during his time in office with 2020 democratic candidates already crisscrossing the country look for president from to also be traveling to states that will be crucial or his reelection greg clugston at joint base andrews in maryland national guard troops been called in residence being told to stay inside after elevated levels of benzene were detected your houston-area petrochemical storage facility that can't fire this week several school districts also canceling classes for the day citing bad air quality the national weather service is warning the plotting and parts of south dakota and northern iowa it soon reach historic levels floodwaters have driven a lot of people out of their homes, several midwestern states wall street the dow up 57 points the s&p seven point tire one of the stories@townhall.com if you are trying to quit drinking or doing too many drugs listen to me you don't know me and will never meet i had a problem like you want i drank and used a party a little too much till he got out of control and almost ruined my life i realize i needed help to fix my problem before it totally destroyed me if you tried to fix your drinking and drug problem and you know you can't do it alone you need to call the national treatment advisors they'll immerse you into a 30 day program to replace your old habits with new habits and 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payments down to as little as $25 a month based on what you can afford to pay 800-709-4395 800-709-4395 800-709-4395 800-709-4395 six booty food and fun okay we are back for another half hour of gut check project it said year three join here with your host dr. kenneth brown this is awesome so this next half hour should be hilarious because were going into chef stores but more important on which we don't do the job we have are from producer marie rieger how we doing i just cannot send it down alright we have also our guest here and i sent to patrick when i speak to eric when she speaking to micah when i got like this to make sure i keep okay so there is something i have instructions already well so for all of about what one hour is so so you start doing this we have this thing guys have this thing i have to always tell people to come and see you keep the microphone close never looks at me with disdain like like i know guys have this phobia about putting something phallic looking right up to your mouth and show a smile and wave smiling way to be okay :-) how these on an emory better nothing ice not well we left off this last half-hour basically talking about your journey on how to become a chef and where you been we learned that he spoke japanese and german hello the spanish and if he traveled and and it the age of five was able to close a cow: yes tied off time off dear: close to a man climbing up the oh my goodness that's like everything but the last half-hour makes me just feel bad about myself wanting you bring your homework for kindergarten and also to maybe climb the cow instead of a ladder knife in her hand and run around your neck you will tell us a little bit more about your journey now to rejoin here the next for some in the next half-hour you have moved into not just shiftwork but you've also been exploring cbd so i know you got a story behind it what in the world brought a chef is now on a digital radio station to explore cbd well just because he was my was my hero back in high school not really know because my my mother died in a diabetic appeared my father passed of pancreatic cancer and my mom died 01 and about that time i actually heard about that they discovered cbd and that was mid 80s i think when they discover that they were really starting to realize that while they made a big push medical cannabis was now legal in in california working on colorado and so i was just fascinated by that how that worked in the body i i don't like the psychotropic effects of of kinsey's audience is the antiaging specific because you know as a chef i always want to fill a coming control yeah that's that personality so i i really am i never really partook in it but when i found out about that that cds and how they affect the body i got became fascinated and so i just i got involved in a business that was related data in and i'm actually a partner in medical cannabis related business and in an tactic, and in massachusetts but we do a lot of really high cbd extremely low thc strains and stuff like that that's cool so my my experience the reason why i'm so into cds that you know i kinda had a heroes journey where i saw some incredible fact did you have anything like that happen yeah so i you and i think i cacti brushed over that little bit with my children but so my son and daughter have a i'm a 20 else on an essential daughter my son was 12 he kept having these ankle injuries playing soccer and he was trying to get into that a lick big development pool and kinda girl that way anyway so about the third time we took him in for ankle sprain in like six months we took him to specialist but i trust and she does i is really long high arches and his ankles are kinda rolled out he think he has cmt like cmt i don't cmts but so charcot-marie-tooth syndrome causes degradation of the neural pathways between and in the in extremity skin it causes type of neural what neuropathy peripheral neuropathy measure and what happens with that and that that the small muscles start to weaken the bone structure starts to deform so a lot of children or or adults with that with cmt will have like a limp wrist were that the wrist turns in and out a little that is truly painful it can be and will actually ache it can be painful but in this case you have to start to lose sensation so my son at 12 is about between 17 increased 18% deficient in the pass-through of you know the impulse from elbow to fingertips and needed toe okay so after testing their likely something that you can do just keep them strong become a fiscal therapy there's no treatment for its tenets genetic so over time my daughter started getting injuries and my son went off to a 2 am text dammit 18 and as as he was like a 18 a week i think his birthday just to curry start school and he was competitive tennis players i know you have a tennis person family and when a debtor where the antennas from the bottom that's right that's right that's right state championship anyway he was having ankle injuries there so when he came out of that that program the only thing i found i done thousands of hours of research looking for anything that could help them in the only true they say is stay strong be active don't get fat that's the three ways that you treat yourself boxers there's nothing else that they've known to to cause any actually to delay the effects of it if if if it is to progress further than staying strong and healthy and so he was very active but i found this this article the cds actually on that while website that i shared with you called echo connection.org and i did some reading i called some friends i talked to guy another dr. physician california anyway so i just i order my said look you take this twice a day and let see what happens and not only did his focus on his schoolwork away up and his grade started to get better six months let lesson six was later we took him to the texas anam research facility where they do studies on neck back and spine injuries but they also do some neural testing and things like neurological testing so first date they deliver the jet they did not look to the genetic marker on that wednesday we know he has it so what they did do a stated a more comprehensive testing on the neural pathways than he had originally the first two times and it was back to hundred percent so now before he was down he said 1718% he's probably got 25% by the time we took in it by the time he went at this time to be tested so i'm gonna kick that up and break something the results we got scolded for i now i do not migrate a hearing and i just want to be a rock star please not constant today this is my season recap though your son that the biggest change in imago simply does adding this evening i was the only change made the only change that was made in his diet and i was very very he's a very clean eater he actually started cooking his own food he was off his meal ticket at school and he saves on a very at enthusiastic weight training program that he designed himself and so but that was the only thing that changes diet and exercise regimen at all we will be look at this if you realize that charcot-marie-tooth syndrome affects the nerves and we know the cbd of the endo cannabinoid system is deeply rooted in the nerves then when that you start decreasing that inflammatory process and what i love is that you just said the key here is to changes.we know that food can be just like medicine and it can actually help out so here we have a college student it's on cbd and eating his own food not eating on diet plan that's amazing and he been well i mean an end at home he was a very clean eaters while he's like the one person the family does like desserts he won't eat cookie dough like anything with frosting on it very low sugar intake refined sugar like fruit didn't live on it measures none none that i'm aware of it i would like to ask a question he has them his hands and feet are always cold but he does have hair side of the follicles can't really thinking that you can go here with any without any ennui that i thought it might be circulatory service account because there's little knowledge syndrome 90 there were to get a little cold and you your it's an autoimmune it's component of autoimmune disease were your arteries sort of clampdown its interest is also a warning sign for autoimmune diseases top bring us more yeah and angry people all over the place have nods yet it's not uncommon you say it just kinda matter-of-fact all of a sudden you know she had 100% improvement there and you know it's one of those things where people hear the stories and you feel like you're being sold something but you say very genuinely it's like what's this thing that a difference in his life and that's why people are so passionate about cbd gasoline and like i have nothing to gain by telling so i don't not financially sure i'm not rr production facility is even open it were still the middle building it in our tech companies $14 million away from making money so if you want to join in the future of the industry go ahead but yeah there is that i just tell my story to share with people so what did you do when you did when whenever he told you how he felt and you knew that it was a real difference it wasn't it wasn't just subjective it was an objective improvement for him you mentioned his grade you mentioned his his mood is energy etc. so those are things as a parent i know that you would be able to easily perceive what did you want to do that information right off the bat and how did people receive it when you shared well immediately i started taking the product i started my daughter I and so because i want to know the effexor and audiology i for someone who is so well versed in the in the in the industry i don't take it on a regular basis i don't know why i have this it's just it just falls off the plate with so to speak when when i look at my daily supplementation but but so i put my daughter on it right away and then i went to a meeting with some people that were interested in cbd's there is a conference going on and i spoke i gave but i just told my sent store i told my story my son story from my perspective and then and i just type i have been an advocate ever since while we all have kids guessing your kids suffer from anything just well there's no way to ike i can't that's got me held that the greatest loss of for anyone ever is to lose a child but even when they're ill i mean or they don't feel w
Shawn Bryans, VP of operations at Green Tree Medical and Chief grower and cultivator for Okie Herb discusses the benefits of CBD, medical marijuana, the variety of customers from the elderly to PTSD veterans, the new laws and landscape in Oklahoma, and how "Bud Tenders" function to deliver great care to consumers.https://okieherb.comhttps://kbmdhealth.comhttps://gutcheckproject.comNancy husband and wife may kiss the bride connectivity care whenever you need video chatting with the doctor right from your phone so I don't need stitches thank you Dr. United healthcare health plan benefits may vary fantastic second episode of the gut check project and we have our inaugural guess this is going to be a fantastic show on super excited about this I'm pretty pumped also so today we have this is episode number two of the gut check project brought to you by your host Dr. Kenneth Brown and well we really appreciate everyone but Joyce did you know we actually have feedback from our first show actually open content by love people I thought that you and I were just talking to each other the whole time as it turns out some people actually listening what you what you know beyond my mom beyond my wife your wife we actually had some of the people who watch that was really cool hate one of the things that we handle in terms of questions was can I take John Teal and do I need to continue taking probiotics or prebiotic's may want to dress like so there's lots confusion around these terms prebiotic probiotic all the prebiotic is on digestible food source that your bacterial breakdown so fiber is a prebiotic okay so the skins of vegetables and fruits are prebiotic's probiotics are the good bacteria that people want to take into replenish your micro bio the reality is when you're taking out trying to you you don't need to take a prebiotic or a probiotic in fact the molecules known as polyphenols are actually a form of a prebiotic they go to your: the bacteria will break it down into beneficial things so essentially and not to be too confusing but you're basically taking a form of a prebiotic by definition by taking out front feels no it's not necessary to take a pre-or probiotic if you feel better on the probiotic I say continue to take it if you do not feel better than you might want to hold off on that so if last week have your listener and you're curious about arch until you can learn more@lovemytummy.com/spooning that's love my tummy.com for discount use forward/spoony also just a reminder if you ever want to keep got catch up with Dr. Brown and what I was doing has a brand-new website called KB MD health.com so it is only a week old there might be a bug or two in there there's actually a probably a lot of bugs and there have changed and I encourage all the feedback if you don't like the language of going to change the wording is a couple pictures of myself that I would change but you know we have to do what we can do and get things up because that website is there to give information about things that we know that at least my patients are swimming towards us and asking questions about what you have all kinds of information on CBD on got health on sleep on brain protection on everything it just a platform so we want to get up there and also to get access to people to get high quality CBD to get access to upfront you and so on so yes there we encourage feedback hit me up tell me you're not a English major are you Meno English majors yeah me bad at language also so basically Eric and I made this website and there's probably some grammatical errors we would love we learned about it sooner than later I know what you're talking about but I do check out KB MD health.com because there is a lot there's got to be resourceful there's lots of research there is a store where you will find the brand-new KB MD CBD as well as trying to heal and will have other things added to the store as we put research behind yes recent research is one of the things I'm most excited about where you have a guest on today and were to be talking CBD in the cannabis industry and all of that supersmart guy Sean Brian's was just talking from outside not just I love historian you guys gotta stick with this show today because it can be super exciting but one of the things I want to do is I really want to do clinical research on my patients less early research I just want to track the results and were to be putting those kind of things first on the website as we await publication and then once we get published then will go and replace that but anybody go to that website is going to see the white papers first before while they're being submitted for publication way it works you submit it takes a few months this is just a way to get access to things much sooner much sooner last mention here a quick for a sponsor that we had for the show which is down weed is happening now with the medical director of Bridgestone and happens to be Dr. J Perry also a gastroenterologist at the top of the hour you probably heard if you're listening already mentioned ridges own and it was being rented by the late great Doc Thompson so I shout out to Doc Thompson again thanks so much for having us here the team chef Patrick Ron everyone couldn't be happier to now start our second episode of the gut check project on spoony radio so we we did not get pulled off the air last week which outcries and actually said you can come back and do another show I got another shirt is amazing so it's been a week before we jump into all the cool stuff to talk about today what you been up to man for a week it has been a week so last week my oldest son the whole family my youngest son the wife and I took tons of family down San Antonio we live in North Texas if you are familiar that's 5 Hours Dr. S. went and I saw my oldest son compete in the state basketball tournament they did well and dad and after that we it inquired when the whole thing so we decided to take off and enjoy some family time out in San Diego we do know I logged around couple hundred bucks I guess online scooters if you are looking for a way to enjoy an urban environment written lime scooter similar while you heard did you get a chance to jump into one of the Navy seal bug training techniques of water cold immersion we did decide not to do that after we put on a wetsuit and tried to serve tennis: water is not warm at all wetsuit is correct your wet your wet and cold and then you're still wet but we did serve it just got out of there soon become fully we went to do good for you let yourself or even wow I had an equally exotic experience I had to go to which I didn't have to I went to Wichita Falls Texas because my son had a tennis tournament there and my wife and daughter went down to Waco because she had a tennis tournament there which coincidentally shot out to her Carlos she double gold singles and I won the whole tournament love that my son Lucas and I in Wichita if you've ever been there Wendy very very windy candy yet and it was raining so we had tons of rain delays all the stuff I did bring my X.3 bar which you will be writing about this also but the X.3 bar is a portable exercise system developed by a PhD named John Jake wish and I had a long conversation with him not to long ago and he's done some great research showing how variable resistance and volatile bottom line is I sat in a hotel room worked out watch rainfall pendulum was probably as wet and cold as you yeah I without question down if you notice now the Wichita Falls in Texas actually is the region that varies the most from year to year in temperature fluctuation it has the biggest swing I believe throughout the entire state shock about the back me up on this by the time he gets in here but it literally has the biggest average temperature swing throughout the entire state that little region at their out of the Red River and – describe a little bit about what the X.3 bar looks like because if you had never seen this thing is really cool it's very portable it's equipped with bands but has has a resistance motion that you know if you're just looking anything that looks weird when he tried it will wear your ass down since in this actually Dr. Jake which gave me a code so that our listeners can execute a discount on ice just when you go you get it go to X.3 bar.com and then put in code KB MD and you get a nice discount there the other science is pretty interesting I'm mobile hacking this is like one of those mobile acts that you can do show is portable you know there's no excuses for not working out take about 10 minutes and you're done so you break a sweat you will think that you won't but you will break a sweat in fact if you go to the our Instagram at KPMG health is no need to do the resident we need to do this because you can see the big man Eric over here is not doing some curls with the X.3 bar actually got several videos of the X.3 bars so about someone else's biceps to do that she actually had to stop mid workout because he was getting too big yeah knows what about changes wardrobe so that would build fitness shared real quick any other news or notes of any to talk about for the gut check project coming up I can't think anything big of them have our first guest this week but I know that you went to where he works while Europe and Wichita Falls yeah that's right so coincidentally and we Artie had him booked for this I went up Wichita Falls right next to the border of Oklahoma Oklahoma just recently became a I'm to say the word wrong but medical cannabis legal state yes is that term that made Sean to clarify we John. His unit tells all about about what goes on yes I went up there and took a look in our CBD product is in that is in that store it was really cool to see all the hard work that we've done to educate and get things moving and so if you get a chance Oklahoma is one of the new states to start the medical marijuana interestingly enough that I do find it kind perplexing that taxes being such a large state watches the bordering states open up a casino or open up the opportunity for medical delivery cannabis or CBD and essentially date it's it's Texas citizens that more or less come support that industry and I'm sure this will be the same until Texas decides to participate I am very familiar with that because I'm from Nebraska originally were that's exactly what's going on in Colorado once I won the other right I would as the casinos Colorado courses the cannabis industry in Nebraska has chosen to be very strict on that so not surprising to me that a state can have neighboring states with little bit more liberal or differing views sure now I understand well I believe listeners will be going to try to start doing is giving over the format in our first hour so it this point time were going to talk about health news as a relates to the gut check project in KPMG health and you can learn firsthand why I always like talking to Dr. Brown in terms of how he keeps up with what's the latest trends and the latest relevant news in health so this last week and we got a little bit of experience with what were going to talk about but it just so happens there's a lot of research into the fasting mimicking diet and what it can do for you and I'm stopping that you can take over so super interesting a study was published just last week about the fasting mimicking.now with the fasting mimicking diet is is this is developed by a fantastic researcher named vulture long ago and what you do is he figured on animals that if you give a caloric restriction meaning your to take 1000 cal a first end and work your way down to about 10 to about 10% of your normal calories in a very specific ratio of fats proteins and carbs that you can trick your body into believing that it's in a fast and what that does in humans he showed that after five days you turn on your stem cells it actually gets your old selves sick and old cells to just go away called autophagy and so if you can think of it this way your body says okay these cells that are starting to show signs of possible early cancer things like that the body recognizes that goes you go away in working to start new cells so that's the basis of the fasting mimicking diet this was developed and a company called L Neutra has developed a product called prologue to sort of make it really simple for you to have the exact ratio that's have prolonged PR OL ON PROLON so vulture has been doing tons of research and you he's I follow his words Rhonda Patrick follows work through a lot of other conferences he's always going to longevity conferences and giving lectures this time something very near and dear to my heart he just published so out of the University of Southern California USC this article out of cell reports the fasting mimicking diet modulates microbiota and promotes intestinal regeneration to reduce inflammatory bowel disease pathology very long big Boring to title but here's what supercool is basically he took mice he put them on the fasting mimicking diet end date induced Crohn's disease and ulcerative colitis so inflammatory bowel disease and then he showed that these mice had decreased intestinal inflammation increased intestinal stem cells they actually reverse the disease and something else is really cool is that they improved the micro biome composition and then he actually showed that it improved leaky gut or intestinal permeability something about this moment we have a disease or chronic disease inflammatory bowel disease if you don't know anybody who has as its brutal this is what I do with my practice all the time but by putting somebody on a fasting mimicking diet you can actually reverse this then he compared that group to a water only fast this is amazing the water only fast did not do nearly as well this is rising I would not have thought that I was completely blown away because I've always I've done I did three fast this year I did 35 day fast the first one was the prolonged one I did a prolonged fast and I could totally tell when those stencils kicked in I just had a boost of energy like you would not believe next when I did I tried to can't hack the prolonged pasture and try to do it using the foods I bought and try to mimic it I did not quite get that boost of energy and then my third fast was a water only fast for five days and once again I did not get that I just woke up at like 1 AM to take on the world and so I've actually contacted the CEO of L Nutro that were extra friends with Joe on Tuesday and him I talked to said yeah because that's the amazing thing we don't people don't realize it the faster mimicking diet is actually based off of true science and animals vaulter did this all he worked out the exact ratio how many days and then after you do this you have to repeat so in this particular group we had two groups of mice one did water only and that group did not do as well the fasting mimicking group had increased the fiddle bacteria and lactobacilli which have been shown to improve so you asked me the beginning of the show what about prebiotic and probiotic I well guess what if you do a fasting. Then your body will figure out what bacteria should proliferate more when we eat it's actually an inflammatory process so every time you eat electrically little bit of inflammation in the gut by giving it a break and by doing the fasting mimicking diet your not only given your get a break but your body goes okay we can get rid of old dying cells get rid of precancerous cells and working to start brand-new ones and is proven it with these mice what is so fascinating to me is that the faster mimicking diet is so much easier than the water only diet I can vouch for that then we had which at our whole company do it and at all trying to I think we have that on our on a page would a blogger yeah I think it's right at a year ago is that's correct and I can I can say the water fast it's not the worst thing ever but it's more difficult the whenever your body decides you need to eat and he had the influx I believe it's called a Rex and it makes you think okay your ravenous and you need to eat and you have a burst of energy simply to go out and find food and I was actually somewhat envious of those who had done the pole on is the control because the and including you that point time did not have the same drive to go out and just eat yeah you are fasting but at the same time your body seem to be tolerating all the better yeah what about fasting I actually after this article got published I realize another article just really got published with a look at the different fasting types in religion and we have Ramadan we've got Jan to pour a lot of similarities to similar with the Daniel fast we have lent which I'm Catholic but not delivered probably should be fasting in a more serious way here that but it's just interesting that the fasting is could be one of the easiest life hacks ever it's amazing that so many religions had that been are are based in insomuch a agent tradition that there are lots of things between religions that actually are incredibly similar and it also comes down to asking so the reason why this such a big deal is because I have my Crohn's and colitis patients and if you do have girls or colitis or annoying but it does please share this so that we can don't help everybody with this because I think a lot of doctors are talking of fasting and so I think my little hatch here who's going to be the fasting mimicking diet plus trying to heal for the polyphenol effect and we also know that he gets rid of the bad bacteria that's growing rich and big plus CBD which attenuates your immune system right could be the magic thing so I called Joe the CEO of Elder Troy and we got talking about this and he goes I want to come down to do the show let's talk and I'm like yes let's do this this is going be fantastic so we can have a whole episode dedicated to the faster mimicking diet and the science of it and you know how people can realize that it really kind of resets and it's an antiaging thing also so you can do from home this is it something it's going to require someone to go out and get a prescription only to prescription to do a fasting and a condign somebody's have to schedule a time to do it and then commit to it and then I would imagine you being a guest urologist to be C70 make those kinds of improvements that's really all you want is the best for your patient and if they can handle that on their own and escape disease it's a win for everyone as natural natural to do it so being vultures studies it's really exciting because what he showed is it is antiaging it is anti-inflammatory and was really fun is that he also so that you have to re-feed so once you do that and you you have the discipline to do those five days of decreased cowgirl of calories and using the fast mimicking diet when you start re-feeding it is awesome because and he also show that if you do it three times in a year that is equivalent to doing ketogenic diet year-round so now that he showed that in different animal models also so for those who at their key billing manager if you struggling as many who don't struggle but if you are struggling maybe this is not turned the computer I have done it and I have fallen off of it and got back on and fallen off it's and get it's not the hot again not the hardest thing ever but the discipline to stay there if you have a family I'm anything you cook for kids then that's not what they want to do is difficult Joe Rogan had Dr. Addie on how dark a joke and I prepare the both of them to deliver talk about the how they just can't rule their diets by making humor and jelly sandwiches for the kids to cut off the crust and Joe just would just eat the crust off the course so I did that also so every time I done Quito I would I would lapse without trying to lapse I would end up doing dirty Quito church where I would build despite outspent direct all is much as I want and then later be like well sure I can have this bowl of rice yeah what you know it with but with Quito if I member correctly you are talking about lab results even on yourself that where Ed there is advantages to doing keto but if you end up doing like he called a dirty keto you might actually failure your desired results off because your body has been moved to doing fats and you've basically thrown in this carbohydrate in talk about that quick so I didn't I like to do so one of my problems in working probably get into that little bit with Sean when he comes on when I do something I go all way way so I'll try it's all just go Quito and then over period of time I didn't realize I was that I drew I'd listen to a bent wrinkle podcast like oh I need to have lentils now is or whatever you know you name it and I totally forget that that's going on so my functional medicine doctor his name is Kevin Wilson here in town and you know he practices antiaging functional medicine she took my blood and called me up his like what have you been doing and course what we were doing is messing with my diet that I'm experimenting with different supplements because were trying to develop more products right and I'm not really paying attention that I'm doing everything at once at the same time sure and all of a sudden he just like your heard labs are messed up buddy commitments and talking alike is what you been doing I was like you have enough time I been doing it all. I'm just everything that it makes it difficult to find out but that's for sure but I will say it every single thing that you have recommended to patient for long as I've known you you've tried it on yourself first I have 100% done that so I have always done it that this is this is not new I remember being a medical student and I was in Lexington Nebraska running the ER at night so I was like the only person awake in Lexington Nebraska at the time and I decided to teach myself how to do an IV on myself which is hard especially first time so let's see I've tried to stick an NG tube down myself that didn't work so well I live but I've done an art I did an arterial line on myself one time that's ridiculous yeah that's not don't don't do that don't do any of this is a matter if I don't do any but I'm just saying that I will do it so that you don't have to share pain of an arterial line is about tenfold of any intravenous line I had left there was a comment on my YouTube channel yesterday where you I posted my colonoscopy online yeah over on YouTube don't do that either and I was awake but it's hilarious actually texted the text this morning with this Abby somebody in the UK said and you'll notice that nobody cares about your but were all looking to screen his writings always get nervous that I don't you see my butt and she pointed out the second he said that Abby looked at my butt and I I've never noticed that so colonoscopy everything so if I'm not you… Come down with everything I really would never I want to try things on myself then I do a case series with patients and then I have data to tell people I was a look this will happen to me this is this group of 20 people over here that were working with athletic Crohn's and colitis communities so near and dear to my heart because I'm using a lot of different things I've seen success with them sure and don't forget the reason why we are doing a check project is to talk about caving the health which was born out of the idea of taking what you find out in the clinic are you going from anecdotal to applied science and to find out how we can actually help people absolutely and so this is cool were coming down to the I guess the bottom of the hours and the rate of the Patrick is that what you say bottom of the hour the bottom of the hour I'm trying to give 30 seconds but apparently I don't how to make a three and is okay since I can call the fountain outside 20 feet away hate that Sean Brian first at whatever you guys 11 I wish you could go some facial is take the pain out of ordering your diabetic testing supplies with diet Thrive diatribe ships the testing supplies you need directly to you when you need them best of all with plan starting as low as eight dollars a month diatribe is probably going to cost you less than what you're paying today diatribe is so convinced that you love their service they're offering your first month of supplies free simply type the Kodak DOC and checkout diet Thrive.com that's DIA Thrive.com never forgotten apparel is more than just a premium women's and men's clothing line it's a movement to remind us to where American-made and serve those who serve us our heroes never forgotten apparel gives 20% of their total sales to nonprofits that support homeless veterans and off-duty firefighters and 50% to individual veterans and firefighters in need nationwide checkout never forgotten apparel.com use promo code Matt and ATT and get 15% off your purchase have you done it did you catch a glimpse of yourself in the mirror I'm I'm one of those people you don't want to see naked IBM most of us but I mean you look and you're going to die I know I get to whatever you call it's horrible hey that's Dr. Townsend and Brad Staggs to tell you about a different way to shed those pounds this is brand-new technically been around for a couple years or so it was based on research from the University of California that said there is a molecule called OEA that's found naturally in your body produces it in the Mediterranean diet that when taken concentrated amounts it will actually make you feel fuller and boost your metabolism I lost about 10 pounds so far is immune amazing ballet school company said we can take this to market to make this great product will help you it's called grid you zone our IDU zone.com our IDU zone.com Brad's work that were comrades work for me countless other people go to read you zone.com and try today you're gonna love it read you zone.com remember that our IDU zone.com okay we're back back to the second half hour of get check project episode number two and now we are joined with our first ever guessed this is Sean Bryant Sean Salo yeah you guys doing today doing well so when Eric and I would talk about our first guest I just sent out I don't care what we talk about but I want somebody with a beard yeah I started this in eighth grade just just just fill in the patch exactly yeah when I turned 30 I look just like there some very proud of my beard for this is Sean Bryant is VP of operations at Greentree medical and you are headed the cultivation division also known as Ogier and Greentree medical and no gear was located in Oklahoma just north of Bert Burnett across the Red River Craig yes sir and you also have a on-site medical dispensary called alternative medicine great yes we do alright well tell us a little bit about what goes on yeah I think it's as one of the coolest things is your background I personally am so intrigued by that so I would like you to stop in the beginning okay well I grew up in agricultural family my parents had big textbased company in Paris Texas and so not really didn't know what I wanted to do when I graduated high school but I had a passion for pharmacy in biology so I got a Texas Tech University and I majored in pharmacy there which was the biology program then I change my major switched over to agriculture fell in love with the horticulture and and I did a lot of research at East Texas State University and Texas A&M commerce on the cotton plant graduated then I became a bag teacher built greenhouses taught kids how to grow went straight into administration became a principal did that for 20 years and love working with people so when my son graduated high school and my daughter she's a but to be a junior it Texas state and that's when I was like you know what I'll I am ready to chase my passion so Oklahoma June 26 they passed their full medical cannabis program and my wife and I were celebrating our 25th anniversary in Arkansas and we talked about 10 miles that day and I was tired she was in bed in the cabin no TV in I just typed up a quick Craigslist ad and I found three guys that were had little to no knowledge of cannabis and how we can use that in the medical field and we made a great connection and I started working with them and that's where I am right now that's awesome so I've known you for quite some time for disclosure my wife hot for you you are the first one the harder when she was a math teacher so I seen Sean is a principal I've seen him as an assistant superintendent of the school district that was down in Texas and I've seen you much like you can whenever Sean decides to do something a Zollo a.m. date from welding to out sing the guards that you value had outback from your house all the vegetables you raise chickens how did you decide that there was a need to go you told me the cell years ago there is a need for people to be able to explore the real practical application yet far beyond the psychoactive aspects of cannabis there are people out there that have a need how you decide that this is a way did you make it happen you know it really I'm researching cannabis and I'm learning about it and I'm sharing this with other people and getting into dialogue with them and these people people that I worked with people that I Matt in a prohibition state of Texas they or one of their family members had a dire need and we started discussing know-how cannabis could help them with a medical issue and so I kind of took on the position of a caregiver by being able to share information that that I gained from from research and keep in mind you know now Dr. Brown can do research and in the public but before it was something that we would just do you know talking to our friends will how did this work with you what were the facts doing a how did you feel that this you know work with this particular ailment but now were able to discuss more freely so you know that that's kind of how I Mr. quick question so you and your scientist by nature I mean with a background in pharmacology and then horticulture and then you are an educator so that your primary start of your foundation is in science then education then you get into this industry with her so much misinformation Howdy how did you approach that were you realize it's up to him you know it's almost like your moral obligation to try and get through all the clutter because that is your back on the minutes if somebody looked at you and said all I could totally see him in the cannabis industry but they didn't realize that you were a principal or rot yet just researching and educating people you know in our dispensary right now when you have a patient come in they don't know what to ask for date they they may think I need this strong marijuana that's got 30% THC but but what we do is we work with them and and let them know that that is not always the answer but you say what you say why are there instead starting check that by now some had a question about medicine and if the physician recommended to them and they don't have time to get those answers that they may have the questions outside face and said they'll go to a pharmacist and then asked the question they cannot take this with this this is just given to me is that this style of y'all that you basically interacting with people and they come in your trying to help steer them toward something that would work yeah so like the way our medical program works in Oklahoma basically you communicate with your physician hey I would like to try medical cannabis as an alternative or with your method of treatment that were currently doing and the doctor would write you basically it's not a prescription for cannabis but it's it's an okay that you can get your medical card and then you come to the dispensary and that is where we want to work with you know the patient's to find out what part of their system is is out of balance and what we need to do to help them get out get back into balance is there a term for that person Soto would like you said pharmacist sure if I go to Colorado was that since little bit more bold is the return when I walked in I need to speak with the well a lot of people call them bartenders that term came about you know right when medical and recreation and they tended the buds that were in the jars and and no new a little bit about each particular product that was in the jar sure now caregivers are though we don't act as the caregiver for that individual patient we are caregivers and so we are providing you know data and information to the patient and let them make their decision and I all white because a lot of times a patient will come in and you know asked that will what will this do if I'm taking Flexeril or if I'm taking hydrocodone or if I'm taking antibiotic you know I always suggest tell your doctor and and let me take you guys this is a trick here it's it's really neat so you go to the doctor with the stomachache normally you go and you visit with the nurse for 10 minutes takes your pulse your blood pressure then the doctor comes in and you know you spend 10 minutes maybe 15 depending on your situation or if you need a rectal in my case abstractly and that's when I stay 30s but know if you if you bring up the topic of CBD bring up the topic of the cannabinoids and tell that to your doctor say hey I'm I've been doing some research here let me take that Dr. is going to sit there for I may not had an hour conversation and the doctor has 10 patients lining up outside waiting to see him or her and he spending his time with me because he is craving this information sure he were sent from a not want to know what he knows I want to bounce ideas you know off of him and and see how I can battle better either handle my own situations or with other patients that I'm dealing with what I would say though even here in Texas where it's not legal yet because you know that but I see almost daily it seems like the openness is is there people willing to discuss something that maybe even just three years ago what going into depth on do you do you find that depositions in Oklahoma are starting to become more embracing now that it's it's legal for them to have this as an avenue yeah most definitely there was a little bit of fear in the very beginning with with doctors they thought that they would be labeled as the cannabis doctor or the lack some of them are the opioid doctor you know which doctor you could go to to get you know drugs like that can and so they there there were some that were reluctant to to even embrace that idea you know it if you if if you're discussing your health with your doctor and you know they do not embrace cannabis in my opinion I would I would want to second I would want to second opinion I'd want to talk to to another doctor what he authors like to chemically so your gastro neurologist here in Texas licensed here and I saw you specifically decide there has to be there has to be something behind the science of the CBD so comparing what Sean's talking about what a physician would have to do to to move into this movement where it's not legal what allowed you to be able to open up and say I want to find out more for the benefit of my patients so we touch on this last week Sean I just I had no knowledge the Endo cannabinoid system I don't alter CBD marijuana I was so whenever somebody is ignorant to it I don't judge at all because I just recently started learning all of this and what change my mind was I went to a conference and I bought a case very expensive CBD at retail price now I'm angry at the company but whatever should be a discount but I gave away my patients and I just waited and when almost all of them came back that I need more that's when I knew that okay there's something to this then since that over the last three years all I've been doing is looking at the science of this and of course there's not enough of research in the United States because of these different regulations and stuff but I'm seeing clinical evidence was why get so excited when we sit here talking I'm I'm thinking when you said much like the pharmacist right dear old Seinfeld episode where it I can't member who was but basically the doctor prescribed something to go to the pharmacy the pharmacist goes I wouldn't do that you do change the spelling of who had more power the doctor the pharmacist I say us three do a little YouTube skipper I'm the Endo Kanab and all adjust I hear the bartender to be the patient, recommend a certain strain and guilt for what I would do that would be a playoff of that but that really is kind words that's where the science is going with this that's what's so exciting when if a patient comes in so I went and visited your store this weekend to right next to Wichita Falls where was and Steve there was told he goes you know what's amazing is the people walking 20-year-old saying only get sweet you know old people with chains and their struggling and there like I'm the real goes here's what peers or to do for you this is awesome and video so when I realize I'm making this what Steve told me girls I realize I'm now making a difference and people's health goes I feel what you probably would and the medicine for which is to change people's lives exactly and and were surrounded by some huge military bases in Wichita Falls and in Lawton and a lot of our customers they they do not by the cannabis that contains THC they preferred the cannabis that contains CBD the high percentage of CBD and little to 0% THC you know with CBD it is it is new to me also as far is it the benefits it is huge very huge you mentioned the Endo cannabinoids system and you know I've kind of in my mind broke the broke medical patients down into into three different categories ABC a being where I want to feed my Indo cannabinoids system I'm healthy I feel good I work out I walk so, preventative it's it's kind of a preventative and then be moving into a patient that that has an element of whether it's a backache or or a inflammatory science laboratory exactly and then all the way up to our need of severe cancer and the end things where you're you're really going to have to to wage a major war with with CBD but yet that our patients that come into our facility even though you could command if you got your medical card I can sell you 3 ounces of gorilla glue which is a cannabis strain I haven't done that I have not I have an 82-year-old man that pulls up and he will buy CBD flower which is it CBD but cannabis contain CBD and THC this strain of cannabis contains 16% CBD and like .3% THC and that's what this guy buys an and loves it he he could buy no THC but the CBD is making different table does make a huge difference Steve our manager and Bud tender you know I asked him I should tell me what you think because he said cannabis user and he he picked up this bottle and he said I take it what it does for me he said in the evening I'll take a eyedropper input under my tongue and hold it my mouth for for five minutes and then I'll swallow it swallows it he digested he goes to bed he said that when he wakes up in the morning that his whole body just feels rejuvenated pop truck got up out of bed he's he's ready to go take on the day that's what CBD does in your neuromuscular system it it if you're already in that number one zone where you're just maintaining it it helps keep a you say homeostasishomeostasis it just keeps a nice even level balance at our level in your in your body and that way you you feel great when you wake up and and then other systems will start to fall into place like I want to get into it also is a move to the show is really heavy for another hour but there there are differences in CBD and when you get it and was labeled a CPD exactly and before forget X1 ass one thing you said that you are surrounded by military bases yes are these are the servicemen coming in getting good grief yes most definitely an and you know when youth historically you know a lot of our servicemen you know they coming with PTSD and and you think of PTSD as we know from guys that the comeback promote a war-torn country and Anna and they've seen some crazy stuff and and they're trying to deal with that and that is that is very true but how huge our military is there there are things that have happened in the military it could be just having a car wreck you know that is traumatizing to you while your own active duty and and so these guys you know they're there looking for ways to to deal with you know PTSD and emotional issues so one of the things we talked about that out my goal would be this you guys beating the people that are selling CBD and selling other marijuana products you can't make any disease claims what I want to do is get research so you can have published articles 1 of the things Dr. Col. Philip Blair is also a doctor of is the medical director at Alexa and also our CBD is powered by licks and always the medical director there he actually published a case series with CBD and its effect on PTSD is a full bird colonel that realize the benefits of CBD and is now working for CBD company and still seeing patients and collecting data and so were to bring him down and he's he's in a come on in the next month yeah what I really want to do it so he so knowledgeable about that and is also knowledge about the other thing that unfortunate happens in war which is traumatic brain injury and he's actually published something on TV guys and we were talking about possibly setting up a CME meeting so doctors need certain minor credits at my hospital door trauma surgeons because I really believe that a protocol of doing high dose DHA plus CBD at the first impact of any type of dramatic brain injury recent article just got published route showed that unfortunately they did autopsies on the boys that were 16 to 19 that had played football but it had shown in these they were there were unfortunately killed from other circumstances but they they are now looking at the brains looking for CTE and are already showing signs of CTE from just high school right so we know that this TBI thing is huge and I just love it that we have like a full bird colonel who is a doctor willing to embrace it you're talking about it surrounded by military bases it's a perfect marriage is a like-minded think is this essentially what you talk about Sean whenever your wanting to help he would've come to you for that help you want to give guidance that you have it's not just anecdotal I think this'll work this is it's it's this works for this ailment we want to help you just like you said you're not selling the gorilla glue to somebody just because it's profitable to you you want to got into something's gonna make him feel better that's the whole purpose right exactly and you know back on the Indo cannabinoids system the way this the CBD works it just kind of columns some of these receptors I guess it it it if if there's something that for instance on PTSD my wife was attacked by a dog about two years ago we were done in San Marcus best in our daughter and a big bull mastiff Jehovah God are yet Torah but Karen carries on a baking sheet for so it's not her fault I was a bacon on me know if done nervously if you're baking carrier don't want grandson Mark yeah well now you know she has a phobia of just dogs but there are times that I look at her whenever somebody if were in Denton walking around where it's a dog friendly town in here comes this guy with his tiger stripe pit bull that's a sweet dog she kinda moves next to me in and she is having some anxiety and CBD is a product that really does help with that and if if if we know that were going to go to Denton she'll consume some CBD and that will you know help help your wife as long as I know you and Karen is never been a skittish or anxious person and I remember that incident quite vividly and you and you're right I arrived I've heard her comment that it's unfortunate for her that that now is something that's a blemish on an experience but I've also heard her comment that Seabees actually helped her not have is anxious. Whenever we meet chal for dinner out then there are yeah and I and you know the Indo cannabinoids system goes all the way down to think 600 million years ago you know it was in little squids and and sea creatures and and still is in most of the animals today and dogs you know there are a lot of people that will buy this product CBD do not give your animals THC please don't but CBD does help with skin conditions with animals with anxiety with animals one of the number one top sellers in Colorado right now are these pet products dog biscuits yeah I see this all the time of my patients they will deftly spend the money to treat her pants and not uncommonly will not have the money for their own medicines right but they will make sure that the pets are the words on my PTSD I'm looking at all the articles were going to be publishing here soon we've got autism and CBD we got CBD and IBD we got a full review of the end of cannabinoid system working to do PTSD and CBD in these blogs are all about science with references so that you can just hand them to people go oh here's this you look at were not making a claim but you can do your own homework just like you did were you felt that moral obligation to get out there and be a caregiver now you are actually going to have to educate in a way without making claims in my opinion is as a doctor the best way to do it and as an educator is to give references exact this is not my opinion this is just based on these this whole process to bring up Dr. Blair's name again that's actually one of his biggest calls is how do I end up taking my research and make it more applicable to the VA and to the basis because these are the gentlemen who are fighting for our country abutting a lot of the line and often times and they go to that system that machine the options are limited theirs is not it is obviously not of counseling the talk button and in the news today but oftentimes it's just to the prescriptive therapies and not to CBD that actually could be making a difference one yeah absolutely I was just talking to him we were I have a friend in Rich Hagedorn back in Omaha he's a retired 30 years in the military and him and a group of guys have started a alcohol company called soldier volley liquor and we would talk about that how they give back to the servicemen and I'm like when we got have done show we'll talk about this I think the veterans are one of our biggest populations that we can really help and I didn't even realize that you're surrounded by military bases where they are they are seeking you out exactly right yeah and and and were therefore we we want to help on the the side effects are just zero that I've seen with using CBD and compared to what they have received from the VA hospitals that cause horrible horrible side effects in these guys they they realize that they're there saying that their spouses are saying that and so they're looking for you know some some treatment that will help them mean everything were talking about comes down to inflammation PTSD information is hyper firing of nerves inflammatory bowel disease the fast mimicking diet that help these mice that is an autoimmune issue what I really would like to do this next part of the shows let's geek out I mean you got a background we can get into the end of cannabinoid system let's clear up some of the confusion let's talk about the other things full-spectrum terpenes blob about the sound sciences but let's let's bring back to level so that when someone walks in your store they listen to this or you can recommend them to listen to it there you know what they're getting just a resale because we are reaching the top of our or just a moment but this is Sean Brian's he is the vice president of operations for alternative medicine newly opened here in Oklahoma and as any other job websites yet we do have on our Instagram is Okie okay I_earth and we also have alternative medicine okay to grant alternative medicine okay on Instagram will see here in just a moment for the next hour also it's funny shows on-demand at spoony.this is the only 24 hour take anywhere platforms dedicated to food and fun career spoony this hour from Townhall.com, editors hope you have at least some information from the black boxes of the doomed Ethiopian jetliner by days end those devices now being analyzed by experts in France here the US FAA acting administrator Daniel Elwell says his agency had to investigate for ordering all 737 Max jetliners grounded it is in our minds now link that is close enough to ground airplanes he was on NBC's today show a former Texas congressman joins a growing field of Democrats vying for the parties 2020 presidential nomination Democrat Betty O'Rourke became a political sensation during his 2018 bid to unseat Texas Sen. Ted Cruz find ourselves by who or what we are getting sore afraid he lost by about 3% but was immediately mentioned for higher office Texas political analyst Jay Iris is more than 20 other Democrats are eyeing the White House works already mobilized younger voters and raised to record money with alive and gritty social media presence of work spends three days now campaigning in Iowa I'm Jackie Quinn as the British Parliament launches into its latest fracture debate president from promising enhanced trade with the UK if and when it leaves the European Union as the UK struggles with bricks at the president is holding out the promise of negotiating a large-scale trade deal with the United Kingdom he tweets the potential is unlimited it's not the first time that Mr. Trump has suggested this last month he told reporters that the US is going to be increasing its trade with the UK very substantially as time goes by White House correspondent Greg Clarkson Wall streets the Dow is down about 24 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whatever all it's horrible hey that's Doc Townsend and Brad Staggs to tell you about a different way to shed those pounds this is brand-new technically been around for a couple years or so it was based on research from the University of California that said there is a molecule called OEA that's found naturally in your body produces it in the Mediterranean diet that when taken concentrated amounts it will actually make you feel fuller and boost your metabolism I lost about 10 pounds so far is a mere amazing Valley school company said we can take this to market to make this great product will help you it's called would you zone our IDU zone.com are IDUs zone.com Brad's work does work for Brad's work for me countless other people go to read you zone.com and try today you're going to love it read you zone.com remember that our IDU zone.com hello and now we're going to start our number two episode number two we are still joined here by Sean Ryan of alternative medicine vis-à-vis the operations of that and that will clear and just a quick reminder start of second hour if you are interested in picking up your own are trying to heal just go to love my tummy.com/spoony use discount code spooning for some savings for yourself and then of course if you want to check out KB MD health CVD you can also go to KB MD okay BMD health.com or maybe somewhere else you go extra you could come over to Oklahoma and pick up some KB CBD oil when we saw this product in our store when when Eric and I met I immediately fell in love and and the first thing that that jumped out at me was you know having Dr. Brown's name on the bottle so many of our patients that command our dispensary that's the first thing that they asked is not what a doctor what a doctor recommend this what is what would end in a lifetime just kind of funny they say what would my doctor say about me using this and that's when I'm likable don't talk to your doctor tell your doctor what you want to do ask your doctor but this particular product that's backed up with with research and an extensive studies we we wanted to be a part of this we wanted this on our shelves the the other thing that that really jumped out at me is how this product was made how it was manufactured how they did the extraction process y'all use a process called supercritical CO2 extraction so cannabinoids and that are on the Kent cannabis plant they are oil soluble and they are alcohol soluble and so historically they would use some nasty chemicals like butane and propane and they would blast that gas which in a liquid form through through the cannabis extract the the all of the cannabinoids and then try to remove some of the petroleum products from that crude oil and in California they do a hunt of testing on that and California is not happy with the trace petroleum products that are still in the considered a contaminant behind it is a contaminant and some of the extraction method they actually feel that that is the containment sure can be yes alcohol so another way to extract from a cannabis plant you can take and back in the day they use things like acetone in isopropyl alcohol's and and some alcohols that that work food grade like Everclear for instance hundred 90 proof Everclear that can be used to extract cannabinoids from my cannabis plant and and do a full CBD extraction now they tried to evaporate that alcohol that that's also an end they can't sure he can't get all it all out yeah I have taken not this product but I've taken other CBD tinctures that staying real bad under my tongue some people like that staying Carlock taking of shot of vodka over you know some type of alcohol drink for me I do not consume alcohol I find it not not always II use to like alcohol but I I don't like it anymore and when I'm treating a patient I don't want to recommend a CBD tincture that has alcohol in it or other nasties in it I want to recommend a clean extracted product that use supercritical CO2 let me answer the question have you seen certain products that said possibly CO2 extraction put on your tongue burns basically mislabeling gallery itself is a little bit wild West right now most definitely met and you know I've had patients come to us and say yeah we bought this said at the jiffy mark down the road in and it doesn't work it doesn't do anything in and I look at it and you know a lot of these products were were made in India or in China and hey guys I it may be the real thing but these guys and and we have other CBD lines in our store also that are that we know the growers trip and just like your guys we we know where this plant came from we know that it was tested we know that it was tested for pesticides we know that that you know it was tested for levels of THC or CBD or other cannabinoids that are in it when I talked to Steve last week whenever we were entertaining the idea of moving KB MD CVD to I alternative medicine Oklahoma the very first question he said is we can't shelve this without a authenticated COA certificate of analysis and can you may want to talk about this why did you partner with Alexa and all-knowing it that there were certain parameters that you knew you had to meet so knowing that the industry itself so let's back up and just look at the supplement industry so my my initial background was in clinical research during pharmacologic studies and then I Neil found a few holes there we figured out we could do something natural to fix people and that's how we develop doctrine until once I get in touch until I realized holy cow the this industries people mislabeling their making claims or doing things so knowing that if I was really get into the CBD aspect of medicine I just wanted to make sure that I went with a company that was completely on the up and up very open and make sure that they had complete sourcing it was an organic farm they could naturally extract which of the supercritical CO2 extraction and religious source to one company so they have complete control of everything and that was a little and the been very happy that I've partnered with them in when you talk to the CEO when we have lunch with Gabe the people that are doing the right thing they want help each other out so they're there all about if you want to do CW Charlotte's Web do that CBD line is lying as he lines another one wherever it was like yeah let's just all were not in competition the good the people that are doing the right stuff or not competition with each other there there to educate and that's why want to part with little there were very open about church said yeah we just want to do this and that's why they want to part with me because they know that I want to be publishing lots of clinical data on this yes so at another big thing that Stephen also let me know is that we have to have CBD's that is full spectrum that we had on this a little bit last week and we can get into a little bit about what full spectrum of what the entourage effect is what you learn some words like terpene's final cannabinoids. Full spectrum and then talk a little bit about somebody who may appear reputable doing things like isolates but what limitations are on that so Sean start you what is it mean for something to be a full-spectrum product within your your dispensary yeah and people that have researched using cannabinoids to treat their ailments that that's the first thing that they asked for they want a full spectrum CBD and it it it it is very beneficial because all of these can I have annoyed CBN CBD and CBG and even THC they all work with each other and and that's why having a full spectrum product here extract it is very very beneficial I just I feel like that it's the way that these cannabinoids work with each other to to address your problem so it we had last week we talked about drugs that have been formed down to isolate said actually underperformed compared to what it was they were they were designed to build a home Otilio told me GW pharmaceuticals's, who are hidden@gwpharmaceuticalsaddress.fda approval for PDO lacks direct appeal something like that something like that that I got approved for seizures it is a CDD isolate what is interesting without republishing more there is a great example because I'm not a neurologist but as gas are all just they did try to look at that particular isolate in ulcerative colitis and ended up having a big dropout rate due to side effects I don't see side effects when I use the full spectrum right not all and will and in talking about full-spectrum hit on a little bit also but to you today different cannabinoids as well as another word terpenes so tripping profile can actually mean something and this is this is great for you because we had talked about where is the science going so CVD is new everyone the ECS is not being taught in medical school and that's a brand-new frontier for a lot of people to talk about but how do you know what CBD combinations going to work for you could actually be decent some differentiation in doing that so much going to walk all through this to you Sean so one of the things that I been either the tunnel reading and when you start looking at some of these people who are PhD's in the writing about this it gets pretty high level it's like any other specialty I'm a casserole dish I spent three extra years learning the got just got the version of the Endo Canavan all adjust procedure and looking at all just because the science is getting so dialed in and one of the things it's really interesting is that different combinations may do different things for different people so we talk about the disease state when someone comes in and says shot I got my back I got sciatica can you help me with that that kind of thing so I think that the terpenes are terpenes are in every plant and it it's what you smell not tomato plan has terpenes is an oil it I don't know if it's in oil but it is a component you know in their structure but it does have a smell to it most terpenes do the thing that just blows my mind these guys that manufacture lactate the vape cartridges and this is the easiest way to try to understand terpenes and how they can affect the way or change the way I can have annoyed's informed you that they you can do a full extraction of THC and CBD and you can take a terpene like why mean for instance and add to that extraction you can consume that and have a completely different effect then if you added a blueberry terpene to that extraction was the island versing yes obeyed immersing is one of them that they look that word they have shown that if you have a higher concentration of beta mercy that crosses the blood brain barrier and it brings CBD with it so if you've got a brain issue maybe we need to start using higher immersing levels Piper Ian I think is the other one that's more for joint inflammation like relearning about this is a brand-new science and Sarandon is so exciting and it's gonna take people with the pharmacy background people mean that's why love what you're doing and when you have this educator background is a science and you're bringing all that into this new space that needs to be cleared up that's what we have in the show to talk about the stuff yeah and seizure patients for instance they may take a they may get a perfect dial in profile of medicine that they're taking and it works so let's say I'm having 10 seizures a day and this is working great after about a month or two they may start having one or two seizures a day and then three months later they may have three or four in anger stuff doesn't work or I'm have built up a tolerance to it that's where I call it resetting the cannabinoids clock making little subtle changes with terpenes to the same profile that that works for you the same ratio of CBD and CBN and CBG that works for you in treating your seizures but I need to reset the way that is working with my Indo can have annoyed system if that makes sense so by making a small change with a terpene they have found that it resets that clock and that seizure patient now is medicated and able to go through the day without having one seizure and then after a period of time they reset that clock in and and start over so it that's why it in our medical profession I cannot wait till all of our doctors will sit down with the patient instead of just signing the piece of paper and synonym to the dispensary because the other thing you know were lucky to have Stephen in our dispensary I mean we really are truly blessed I had a patient come in the other day that had gone to a another dispensary that had two ladies that were retired kindergarten teachers that were working at the dispensary in you know they had no idea what was in this model innovate they just knew that it was this process and you know for the same reason the matters we get to CVD are probably matters on his help guide you to listen work for so when I run into whenever I see anybody there's quite a few multilevel marketing companies which are try to get into the CBD industry and what I have seen is that if I go to like a tradeshow or something the have a booth I'll just walk up to me like what's this and listen to what they say and everyone that I've encountered doesn't really understand it and are just throwing the words out and try to do the skills you need this this is the is isolate this is this it's got a full terpene spectrums or will we limit so isolate nursing turbine spectrum dual turbine is no and let my kids laugh because of the accident happened about five times Robbie will tell me more know you wrong that is it just education thing but if you're just trying to move some stuff there ever is using these words like did you heard the term broad-spectrum so broad-spectrum is a marketing term is no such thing as each of the broad-spectrum and I cannot find it fascinating that that's catching on, the Joe dirt style of selling the difference tween blue sky pasta Dragon just does well Doug number one thing that we look for is you now want to know how the medicine was made I want to know where the cannabis came from and I want to know that it was tested and that's why I can't always recommend going and buying this on eBay this on that you stay online for $5.99 in and think it is really going to it it may hurt you your point is now I want to hear your horticultural background how you guys grown up their local well it's funny because you know going into this you know I'm res
Welcome to the GCP, your host Kenneth brown, MD along side Eric Rieger, CRNA. Dr. Brown introduces why he launched the project and where he wants to take the project in his journey to bridge the gap between medical and natural science. Check your ego at the door and listen up to the GCP!All right welcome to the gut check projects I am Eric Rager and I am joined by your host on the object project the board-certified gastroenterologist Dr. Kim Brown what of your own show while so we are now on the gut check project this is the inaugural show John just thinking that we been planning on doing something like this for a long time with this incredible opportunity to do it with these great mentors Jeff Patrick and all these other great guys here doing this incredible production value now we have a studio on thinking that maybe our tagline should be something like the gut check project let's all check our egos at the door and learn from each other nothing is off the table nothing is off the table in fact we have a bunch of stuff on a table so this is our first episode people may say get check project sounds great who in the hell is that guy he says he's a doctor but is not wearing scrubs want you tell us a little about yourself Dr. Brown so my name is Kenneth from a board certified guesser neurologist I do want to back up just a second and explain exactly why were here because of a few weeks ago I had the opportunity and the pleasure to come and actually be a guest on Dr. Thompson's show here on mojo 5.0 chair and then we came over to spoony radio and we had a great show you can go to the YouTube channel take a look at that and unfortunately a few days later he was actually tragically killed so I just want to pay respects to that and say thank you we wouldn't be here without him I had such a great time with him and he's the one that explained man you you can do this you guys should have your own show it's really fun so unfortunately you know we lost as great guy and he's the he's the real reason why were sitting in this particular Studios I got so excited hanging out with him so no doubt yeah so as I said my name is Ken Brown board-certified gastroenterologist I'll give you almost give you the whole story this probably led people to don't know anything about me so I probably don't I'm I was actually born in Lubbock Texas that's right big red raider big red raider briefly parents moved almost immediately to Nebraska so I consider myself more of a Nebraskan and I went to medical school Nebraska my fourth year of med school and scraping ice off my car and I just went now done with this move someplace cool and warm and I just ran to Texas and so I end up doing the rest my training in San Antonio and became board medicine certified in internal medicine and then gastroenterology and since then moved to the Dallas area Plano Texas have been practicing astrobiology for while too long now capture a good while not a rear end yeah yeah a lot yeah we do I know you know I may, but Dr. that's why say nothing is off the table were over here and so I have two kids I have a Puerto Rican wife so we speak Spanish in the house I worked very hard so that my family can play a lot of tennis and world spoony radio we got chef Patrick being a mentor here and as it turns out my family's total foodies we love sort of bonding around foods was a perfect environment when this diner setting to great way to launch the show so I will ask you Eric super fly reader think that's your juror yeah yeah now would I? My parents always told me to find the esoteric I know that you are a child actor would breathe. You did you are a rodeo clown right and then your male model yet and so what if what you doing now besides help me host the show well I was in the middle of inventing a mechanism to create high temperature ice cubes and I didn't really work out so I was a melting every time there was nothing I could do but I will say that that led to me deciding to become a cRNA or a certified registered nurse anesthetist in and back in 2012 and in meeting you and we've been I was your anesthesia provider is that you are working in gastroenterology and course I work get a few places outside of the G.I. clinic to deliver anesthesia as well but I also have a wife and two sons they are not into tennis but very much into a competitive basketball and both in high school now and so that basically led to me working alongside you and next thing I know just like every aspiring gastro neurologist and anesthesia provider I ended up on a podcast there we go so you so it looks like your tRNA you've got kids that are heavily involved in basketball trip I do believe you work for another company called trying to let you dear to my heart which will talk a little bit yeah and you even have worked for a particular company and still have a part owner of that right yeah I am a small owner of that at one of my best friends I grew up with in Gainesville Texas his name is Scott Willis and several years ago he just approached me and said I'm gonna start to kill company by myself unless you want to help and I knew nothing about an essay that sounds great let's do it so we asked people for money with a like to invest into killing people like investing in alcohol and he back in 2012 when I met you he launched tequila 512 and that's based at Austin and they slowly are going out as an organic tequila and he's a doing quite well very excited so we both are involved in several companies this what happens when ADD just meets momentum and just keep going and we decide yeah let you several podcast now beautiful studio that has no great mentors like I'd mention like working I have the ability to have his high production value would get the cameras this is stuff that we could never do with you and I have talked about in the pockets before but I'm so excited that were on spoony radio right now to actually launch this weave we been involved with a lot of great people of last few years I but I've done a lot of podcasts without question yeah and we've made some great contacts and basically all those guys everyone the practice we got on guys like Chris Presser and Rob Wolf and I could just name we've Done Ben Greenfield Tunl., Park as they've all been so clueless and kept in touch and said would you guys have your own show we can do this I would love for spoony radio to get big enough that we can start flying these people and having great shows and talk about different things that's my ultimate goal with this so no support of the shows will be really important I would say with the mentorship of Doc Thompson in the course in his wake you still have Patrick you still have Ron you still have that Tom and all the company really picking up and pressing with spoony radio that it won't be long until that happens and you know you do doesn't just stop at those that podcast that you mentioned in your event on know you even on the wellness mama you even Rhonda Karen Fitzgerald the exposure that you had there from the going on all those different types of podcast I think is well this is really eye-opening so tell Silbert about why are you doing this podcast after doing all of those podcasts every time that we have the opportunity to go on with such great people that were really established if they had like Melanie Avalon okay intermittent fasting I went on her intermittent fasting podcast and because of the research I did for that now I practice intermittent fasting so I start looking at what everybody's messages we look at Ben Greenfield's bio hacker love the stuff is doing I looking everything that he has going on that's all, now I have a infrared sauna I got a vibration plate I got I'm doing all the file hacking because of going on been showing talking him but all that stuff and you know I essentially I read Rob Wolf's first book I have read a second book yet but his first book of the pillow solution great book I realize oh my goodness I I'm wanted to change my diet here so that we can I can be more pale you every time I go to show Chris Kress or the compressor Institute holy cow fantastic functional medicine doctor I'm a traditionally trained MD and honestly he opened up my world to the aspect of treating a patient holistically and working on their lifestyle to make everything better he was the first person that I got in close contact with it was actually talking like that so every time we do want these podcasts I grow from it I become more robust I become a more holistic I've just grown from being a traditional trained MD to more of a functional gastroenterologist and I really want to thank every podcast I've been on a map to get some really fun ones with sexy brain the author sexy brain right that was a superfund one sure it's just her whole philosophy is that you have to as we age continued of sexuality in promoting that protecting the brain and you start seeing certain themes what were seeing is protect the brain in my motto it's all health begins and ends in the got pregnant you get is unhealthy everything else is going to start breaking down on you so we can protect your gut and we know we can protect your brain and if I can get you to sleep then we know that all the pillars of health are covered and were going to hopefully bring all these people in to give their expertise in each one of the spots that's gonna be the real goal of the show is to bring education that I'm out there talking to people with after I would do is show I was shocked at how many people would contact me from all over the country if not all over the world and they would set her doing this podcast you mentioned this one thing can you expand on that a little bit more like while they're emailing neither do this I just on the podcast that was it people try to make appointments with me because they were so frustrated that their doctors were not listening to them and here I am learning from authors we have bio hackers we've got athletes with professional athletes that we been talking to I feel like with the whole point of gut check project is check your ego at the door let's learn from each other and if we can learn from each other and I can get that message out to more people I truly believe that we can change the landscape of health someone to say something here I've known you for several years so I know and I seen your patients come through and I've seen where a lot of this genesis of new ideas and new applications of what you want to do with your patients and how they begin to receive it because we see them in the G.I. lab and we seen the from the very beginning and 70 they begin to feel better and they talk about not only how is it affected them but how they want to share that message with their own family and then lo and behold I believe the first actual podcast that you went on he didn't have any warm-ups you went straight to Chris Chris or because we literally did not know what you're getting into and it that point you went on and really it was less than 24 hours it was published it suddenly phones email website traffic on and on and on people began to reach out to you long outside or far outside your nucleus of where you have your practice and in North Texas it was multiple states tell me what about that what he did do for you to recognize what that platform is doing for you and the message that you had for people to get better what that told me was that the people that were listening to that podcast had a trusted source there was no agenda it's just somebody that they trusted and they listen to that and they wanted to continue to believe in whatever he was sent okay when it's a podcast you have the ability to subscribe or not got stuck in traffic and I just pops up and it does this this is what this shows going to be about I want to talk about stuff that I truly believe it also I want to talk about things that I have seen success with I have a lot of patients that have had tremendous success of doing diet changes supplements no change a few things work out routines and I get tremendous benefit from that and none of that other doctors are talking like that will the platform is bigger than this we have to get the word out when I learned something I want everyone to get better so what Chris showed me was we just jumped right in that that medium is so powerful if you're honest if you're talking science if you're backing it up in your bringing guests on that are doing the exact same thing that's what I want to do with this I want to bring typical scientist like that to talk research to help out with that kind of thing so somebody has a question let us know hey can you talk to us about antiaging will reach out to me that I have goals and aspirations Peter Addie as I'm a huge fan of him if you don't know who he is he is an antiaging specialist pseudo-roots I get some other interests also jujitsu and things like that you know eventually will have some you know Joe Rogan on the show that's my aspiration to show off you may be a little much on the first show to say that but I think we can bring it work a merger bridge the gap between traditional medicine and functional science or natural solutions okay so you just hit on something else in another room to touch on eventually and just so people know the idea behind gut check project is every Thursday from 9 AM to 11 AM central central time we will stream live and in the course will be available recorded after that but every Thursday that's going to be to get check project and while we know that that's all going to do going to have basic themes every single time that we do that and what has enabled us to D's to decide Dr. Brown how to reach out to people on this medium is that he does want to bridge the gap so that something I know they were going to talk about the next half hour but what is it to you to bridge that gap what is that mean specifically because I know that it's between medical in natural science and the applications of the two what started my practice I came out of this the classic Midwestern medical school training center and as I've mentioned of learned a lot there about different disease applications in different to the disease states and then once I start my practice I started doing clinical research and pharmaceutical products that were being developed and it was fascinating to me I saw the whole process of how a drug a compound starts what they have to do to get it to market how they have to get it FDA approved the studies that are done and I did those studies there's limitations set it costs to hunt them on a ton of money and you not to spend $30 million to get a drug approved if you're not, stacking the deck your way so realize that there's we need research when I went to medical school it was the dawn of the evidence-based medicine approach or so before that it was always you know you just had this mentorship were the guy in front of you taught you what they did and so on that was the Socratic method of teaching now all of a sudden were talking oh we need evidence-based medicine that everything became evident the numbers didn't add up no go no go yeah will guess what if you get enough money those numbers can add yeah something you can buy some go you can buy some go yeah and that's all that's what I was seeing so because of the traditional research that I was doing I actually was able to find some holes and that's how we ended up developing a product called archer until my baby very close to me if you have any washing you can see this is arch until I saw green packaging will get into that a little bit more but bottom line is do me a favor everybody go to love my tummy.com/spoony spoony SP 00 NY show some love you we want to support this station not just for us but also word trying to make sure that Dr. Thompson's vision keeps growing keeps growing and that's one way to do it is to support the sponsors happens to be that I'm honored that my own company is a sponsor and still offers the 100% moneyback guarantee and they did it before we're given a show that's what so cool yeah oh yes they did so props through our CEO Chuck for taking a bit of chance there and hopefully will continue to grow subject so we have talked over the bridge again you've obviously hit on the fact that you are the creator and a researcher behind the development of John Teal it is a natural solution you did do testing on it for IBS bed legally here in the United States have say bloating ironically enough though when the product was invited with open arms by the intervening Canada what is it we can St. Canada a as he cracks a Molson so yeah it's very fascinating we just got our NPS and NPS the Indian NPN number in Canada and in Canada there is a very different than the US they actually they don't want you to talk around issues like what do your studies what is show what is it show what is the disease state so in Canada were in Canada our new labeling says irritable bowel syndrome in Canada and not have to give some props out to I I do a lot of hemorrhoid work and the hemorrhoid work the company that I was using CRH medical actually called them this week because like how we market in Canada how do we team up to do this as it happens the the the products and not try to help with bloating and constipation which ultimately bloating constipation causes hemorrhoids and liquids team up so that's another thing that will get into but it's fun note launching a different country different culture try to feel what's going on so yeah so in Canada we can say irritable bowel here we gotta say bloating and the vague terms what were all looking around and shifting our heads because this is our first half hour ever the yeah of the gut check project but what I can tell you is you view tuned in so far hang with this for the next hour and half we can talk a little bit about what it was for Dr. Brown to research what it was about the creation of John Teal where he is on the ideas of the cannabis industry natural naturally apply medications on and on and were still going to get into some of the fun stuff in fact what's is all God's name you can guess go ahead and email us the first 17,000 people to email this will get a green too thick yes so the inaugural show we realize that we needed a mascot were calling this guy got see he's up frog on a toilet with a phone correct and I figured that if we had somebody here gutsy that if somebody had a question I couldn't answer we have this little guy call up an expert because of all the work we've been doing I do know a lot experts do know people there are experts in all kinds of things you have an expert next week were to have an expert next week that's correct and probable have experts every single week on topics of anyone has any topics they want to cover KB MD health Pat Sajak came out with stage IV pancreatic cancer to wrong I'm wrong with that database Alex Tribbett will extra back they I watch a lot of TV sound now you did not ask it in the form of question here you did not so it's very sad but I cannot today and I started thinking I was like oh my gosh I had people texting me all morning long hey what does stage IV cancer pinker cancer may not like them when my partners I got to partners or pancreatic experts that will tell you everything about that that's what these guys do we have a pancreatic surgeon that I work with all the time you see a statement Naomi Joshua so he was so brave he did it and is very is very professional tone and even through to a joke saying he knows he's going to survive because he's got three years left on his contract and amp and it's it's of incredibly difficult thing to go through knowing that he I believe is 70 years old is he really saying he looks amazing he looks incredible after all those insults by Sean Connery through still looks like Eric and sucker Trebek had no eyes shut up saying I live and the yeah the Jeopardy's lead with that will Ferrell and all and in the Sean Connery and Burt Reynolds impressions Ella some of the greatest things when I saw that that he actually a bank of cancer for sale but it was S&L yeah gotta watch you not actually watch Jeopardy but the first thing I thought of but that's good for him for embracing it and things like that bring awareness so if there's anything like that going on were delivering those experts people have questions let's talk about different things that help prevent that like healthy lifestyles and really big in the diet various diets and all do them all one of the route you want to think is going on these various podcast meeting people I do a lot of lecturing and Saul go to like Paley why faxes yeah right one of love that come from great conference great conference and got a note the opportunity to actually lecture this year there will probably be lecturing next year also Michelle Noris called me up and said man we really want you to come back there's a great example of the ability of diet to just completely change people's lives Mediterranean diet in no profound anticancer diet and you were to hidden all that stuff check but it's not just going to be my opinion it's going to be backed by science we can sit there and talk about it working to try and bridge that gap like we mentioned and if it's complex conflicting with complex something that's really complex as the Endo cannabinoid system the ECS and in fact then actually leads into a little bit something else we we may have neglected and this is a gut check project the gut check project is basically brought to you by KB MD health so this is Ken Brown can Brown medical doctor so KB MD health.com is where you can find a lot of the research it will be posting is a brand-new website started a week ago and from there will be able to help bridge that gap and show your methods in terms of the research the proven science what works what doesn't work and you can even give suggestions on people you would like to see him get check project from KB MD health I don't it's we talked about Halifax I think it was three years ago that I would spell effects of the speaker just to check out to see if we should be a sponsor and that's what I want by the elixir no oh yes and a looks and all is I've since learned is a company that is fantastic they been doing the right thing the entire time tossing IG industry really vetted a lot of companies and ultimately is the company that I partnered with but is really funny because what happened as I walked by the booth and a person is not friend Christine said this is three years ago hey you you know anything about the ECS and I am a medical doctor like I know absolutely nothing and she just proceeded to vomit so much information on me that I liked what I'll buy a case ship it to my office and I literally handed out hemp garage CBD to my patients for free and I just said look I know what she was saying at that time to there's so much information was coming at me so fast all I know is that just about every patient came back and said I need more of that and that's when I knew that okay I need to do a deep dive for the last three years I've been really diving deep into this doing more research this is a functional medicine type research were to find different ways to apply this but using science will have fun but I also want to talk science downdraft talk sets in fact working to get into that later today about ECS and what it is that it means to you and then I think you and I can both completely admit that regardless to manage the training or your med school and why not ECS not talked about we talked about the digestive system we talked about the skeletal system nervous system etc. that particular system which everyone has completely and it's fascinating because it's just not talk about a medical school and so when you go to medical schools do we get busy yet and we don't know that's our job will be teaching that and were looking over at one of our mentors here we got music, and I guess that means we need executive break as the first half-hour catching project holy child thank you all for joining us we will be back here at the bottom now you can fly anywhere in the world and paid discount prices on your airline tickets flight today to London Paris Madrid or anywhere else you want to go and pay a lot less Gary call the international travel department right now low-cost airlines 800 452-107-5800 452-1075 that's 800-452-1075 fast-track student loans can get your student loans out of the vault stop any wage garnishments stop collection calls and stop seizure of your tax refund give yourself a break to stop the stress and get your student loan payments down to as little as $25 a month based on what you can afford to pay 800-709-4395 800-709-4395 800-709-4395 800-709-4395 have you done it you catch a glimpse yourself in the mirror I'm I'm with those people you don't want to see naked IBM most of us but I mean you look and you're going to die I know I get to whatever you call it's horrible hey that's Dr. Townsend and Brad Staggs to tell you about a different way to shed those pounds this is brand-new technically been around for a couple years or so it was based on research from the University of California that said there is a molecule called OEA that's found naturally in your body produces it in the Mediterranean diet that when taken concentrated amounts it will actually make you feel fuller and boost your metabolism I lost about 10 pounds so far is a mere amazing Valley school company said we can take this to market to make this great product will help you it's called grid you zone our IDU zone.com our IDU zone.com Brad's work does work Brad's work for me countless other people go to read you zone.com and try today you're going to love it read you zone.com remember that our IDU zone.com all rights we are back with the second ever half hour of the gut check project I just heard in my headphones alive and read for which is the riches of I have heard of them also into Rich's own my good friend Dr. Jaeger. The medical director of that and this is super exciting because ridges own happens to actually function like a typical cannabinoid that said the science that we could get into the oh EA oh eat a fascinating it is in all of oil extract that when he gets in small bowel it gets broken down into something that functions like an Endo cannabinoid it suppresses your diet I have no stock in the company of anointing only CJ and his CEO Cecile Sasi Sasi on CJ and Sasi Excel 1 of the things that I do want to bring up on the show for everyone I want everyone have all the knowledge I want every company to succeed I want every advertiser do well basically what I'm saying is a rising tide lifts all ships it does indeed just to reset this is Dr. Ken Brown this is his first episode of the gut check project he is a board-certified guesser neurologist so we left off last half hour talking a little bit about will why were here and the whole idea schedule bit more specifics here for this half-hour so you last half-hour you mentioned that your you want to build bridges between natural and medical science and that's a really kind of the flyover term is a lot of debt to that and I've seen a lot of that debt since you have been working together so once you go ahead and and tell us a little bit about what that isn't what led you from going to med school working as a gastroenterologist all the way down to the road where you want to see what works on both sides both medically and naturally so like all things always go back to school thing signed like all things I think one of the most influential people that has affected my career is getting Leonard Woods was a physical therapist somebody that I also get even a step back further and so good work you have all these people is just so I grew up with a great friend and Junior Bryant he played and of going to Notre Dame and played football there in 49 or 49 of them played for about 12 years and 49 as well a lot of people don't know is that his eighth grade summer a water heater exploded and burned him with his mother he ended up living with me because his mom still in the hospital so he calls me up for Michigan and says the doctors go discharge me I kinda need a place to go riding and asked my parents right beside you live with me still dental my mom and dad hey Junior as you live with us so he spent some time with us and a moment happen where the doorbell rang and again I said my name is Leonard Woods I hear that you have young man has been burned I'm a physical therapist I want to help out at night like okay and then he ended up taking rehabbing Junior making him state champion shotput go to Notre Dame Fulbright football playing whatever the junior always get back to the burn burn victims and burn burn community and now were talking with him about CTE and football and all that so it's really we kept the relationship going little puncture but when you when you have a moment like that were somebody just altruistic Lee brings her doorbell Chris Acree people out on the doorbell you now but but but 30 years ago some 30 years ago I don't yet I don't date myself so yeah so anyways that he pulled up his horse and buggy and but so that that I would be physical therapist and so I ended up doing all through college I worked in a burn unit and I just I did trauma victims and things like that and then I ended up doing mentorship with Woody Leonard Woods when you really admire somebody and he pulled me aside and said dude you need to be a doctor I think that this is I think there's there's more out there for you and then that's when you go from believing okay I'm here to the guy that I really admire says I can be here sure and ever since then it's just been a passion to just break down barriers and figure out ways and hopefully due to her altruistic way and hopefully do it in the safest way possible and so on so that's I got into clinical research so after much about school did my fellowship two years into working at D had to just of health Associates Sgt. clinical research and I one of the first projects that I did was on a drug called by fax and Dr. Mark Pimentel if anybody's ever had any experience with bacterial overgrowth called SEBO well he's kind of godfather that he definitely is located on California and so when I saw the work that wouldn't do that now is one of the leading enrolling sites in the country for their first trial that ended up getting published in the New England Journal of Medicine so they spend like $30 million to put the study out there they go to him to be a speaker form I'm watching all this this is fantastic it's a novel treatment it's safe it's everything that I'm all about its new science that makes notes older at the 11th hour the FDA pulls the rug out from under him and says you know what we want more data they'd already hired salesforce they had already had people that had moved their families out of money and time so much money in time so there is the whole machine is so much bigger than people realize there's a lot of people in the farm industry that are put their whole life on the line. So it's not like this is good or bad it's that these are just different industries and you we may have a few things broken I think that possibly we allow devices to come to market maybe two quick look at a show called the bleeding man she had a bleeding edge on Netflix that'll kinda get into that and on the flipside I think that we have products the FDA is just there to show if it's safe so the 11th hour the rug was pulled and then they had to do a hold of the trial that took about four more years will in that that. That's when I was looking at it and am still in contact with all the scientists around the country and I'm like wow there is a big hole being Mr. we could probably solve the problem using mother nature okay and that was the first time that ever thought about anything like this in the actual story behind this event to return any of my other podcast my real story is I'm talking to Dr. Pimentel he is explaining that will never be able to help the bloated person with constipation is there producing methane gas by fax and doesn't affect the type of bacteria the produce is that at that time I research manager Brandi comes in my office is like why did you write method on the board such scruff the phone as crazy as it turns out it's about methane which is very time appropriate because that Congresswoman oh I forgot her name so we will have to remind about that that that young woman was talking about the greenhouse effect and how we have to get rid of cows Co. Locascio yes I just read that on-site home and we been talking methane and cattle for a long time lesson Brandy goes hey when I was a policy letter for Sen. in Iowa they were trying to mandate that farmers put certain food products in the cattle feed to prevent the methane production in the stomach I think she had inadvertently on her website to her big thing was that she said how parts were causing everything sure is really Cal burps because I just ruined it right and so that's what's happening and that was the aha moment I just went holy how it literally literally holy cow yet a bloated cow came through with all this and that's when I said can get some of that data all that animal data somebody did on leg workforce it's out there just nobody's taking the time to do it because everybody is focusing on rocks that's how we ended up developing outrun to and I believe it's tip of the iceberg I believe that we can do this with other things one of the things we have in my back pocket I have a I have a good friend that is an incredible researcher she will find any article ever any time and so somebody has any questions about hey does this work but no let's see what happens a lot of times the problem with doing natural research is that you even know what you're actually looking at right what I mean by that is there is a study the cannot 2015 where they looked at products at GNC Walgreens the major the major players and they show that almost 79% of those products did not actually show what was in the capsule what was on the label through DNA analysis right so it's 80% of the stuff that you taking might not be anything I not be anything I don't think that the people that are marketing those those that products really care they only care they got caught well it could be that it could be that they don't know that they may not know they may not know you have the best of intentions that a leader you will certainly without her until we hire our own third-party testing rack check the top middle and bottom of every single batch of natural ingredients original does that also absolutely that's why the KPMG health remember upfront till go to love might help me.com/spoony SPOONY show some love with that because that's just going to only keep growing and so when we start talking about natural research the first thing we have to do is are you looking at the ingredients are on the label lemming that is a recent study just came out pretty basic and melatonin melatonin does amazing things for you there's lots of evidence that it actually work on your end of cannabinoid system we can help with your acid reflux it helps you sleep and a recent study to show that when they analyzed melatonin it could be anywhere between .5% to 400% of what's actually in late right so when we start talking data if I come to you and I'm like you know Eric I would like you to start using reserve patrols and antiaging product to show me the data and the data is inconclusive it's all over the map that's looking the people that did the studies may not even realize they didn't spend money to do third-party because it costs so much money how they recoup now you're right on and I also think that in the natural space number one I think what you're alluding to is or may not be enough money in there to publicize the results another thing is when people are doing natural research there researching without prejudice they are doing it to find necessarily just some print a pre-determined endpoint they are just trying to say this is going to work and were going to make sure the numbers were there just doing research reporting research and sometimes it just lays uncovered because it's not heavily funded build on the search for just as you describe and it lays dormant until someone begins to put the pieces together so, describe how that had applied to you and in terms of what you wanted to do to build a bridge between natural in medical science from understanding what natural could actually do to give real results so in my practice and seeing things in my own self like I said I'm but I consider myself as the bio hacker to a fault I will do all go on like one of mycelial were my favorite pupils Ben Greenfield it's funny because he'll do anything to himself I called it when I want to show whatever we we talk research we always talk about the and of something meaning the number of patients to have an outcome and so it's the end of one the end of two whatever I called it the bent of one anything to them so I'm kind like that so I'll call I'll do a podcast the patient will tell me something like I'm on it yeah let's do this and see if it works and I evensong myself I would order different brands of the same thing and I could see different results so you know that there's different things going on so the first thing is I want to make sure that anything I recommended to the patient was third-party tested trip so they know exactly what they're getting so if I say you're going to have better sleep because this melatonin to work I know that are trying to is NSF certified so you can as Olympic athlete you can take that right are certain certifications for that that actually led to my own digestive group she had actually were about ready to launch our subscription box where health arrives to your home were to do that vetting for you which is so cool that they're cutting edge enough to do something like that so basically it's a large G.I. group that knows that their patients take supplements and they want to make certain that if they know their patients are taking supplements which are over-the-counter and they have the opportunity to take various supplements and all different kinds of brands this is a G.I. group it's taking a step forward and say okay we know you're doing this let's help give you some guidance is that, you're describing that's exactly it and this is all going on right now as we speak so amazing it's so cool this was actually present we have a unique opportunity I'm with Simon several healthcare entrepreneurial groups I think I've seen you at the meeting of Bender wanted to do so word several groups and because that were exposed to some very exciting people both in the science side and the business side trip and one of the people he came in contact with he said looked if you guys are so concerned about the health and your community take some ownership of it step up front and say I want to at least vet these things for you and in my opinion if you cover the three primary pillars of health which is gut health all health begins and ends in the gut forgot isn't healthy nothing else will be brain health what's the point of all of this when dementia and Alzheimer's is exponentially increasing must protect that and then forget about the other side of the epidemic of autism right onto the roof left brain health also share an anxiety and depression and all the other things and then ultimately sleep if I can get if I can fix it got protect the brain and get people to sleep there can have all the things they want in their life which is weight loss more endurance better mental clarity all of the above energy happiness and it comes with those three pillars no doubt yes I'm super excited that my company D had decided to do this I want to double down on this right now and say that I truly believe it will be the first large group to do natural research and just show unbiased research that knowing full well that is not to be a whole lot of financial recourse in it but were doing it because we care you want to change the landscape of the health and in our community and hopefully expand beyond our community through stations like spoony radio sure so eight nowadays you you definitely see kind of this this weird split Emerging where if you were to go back to the 80s it was if you're sick go see a doctor and you and your physician so if you're sick go see Dr. if he and you feel this way and you don't feel well go see a doctor and then ultimately that time of course all physicians for the most part want to do their best by their patients but they can they can only do it from the research and the information education they received in school why do you think that we had to shift over to natural medicine number one number two what is it that kept people from embracing some of the natural medicine and then maybe even what are some of the limitations in leaving the medical world behind and ignoring still the good parts that could be in the medical side all just for for natural because you say you want to build this bridge what is it about the good sides of both bringing them together to help people find relief that you found that this is a reason you help people build this bridge so when we look at the pharmaceutical industry will people don't realize is that the way that pharmaceutical companies can communicate with doctors has actually changed over the years and I've done that probably for the good of the whole industry trip in my in my opinion I mean when I was in medical school it was pretty wide open I will get to a look at there's a whole lot of of pharmaceutical reps would have to spend the money hey wait a minute that reminds me of a story and never do the job but yet you good drug rep at one time it's not important important thing is is that you learn lessons and you move on so my marinara care was actually he's been in multiple industries I want you to tell the story because I think it's a really cool and I think it shows where you are at the whole time sure about the hamburgers yeah so we we often were given entertainment budgets and I know that you were the beneficiary of some those entertainment budgets both as a medical student and of course as a physician because how else are you going to get someone's time to tell your message you are a a drug rep and you feel altruistic and yet this is not out there I'm not judging any shirt field or anything it's everything the business over things and industry everything what is it's really hard it be really hard to to see me and get any attention if you're not gonna bring in some food my staff is just the nature of it unfortunately when you and you have to get access because you that the physician is there to serve the patients and so how is she going and access but you have to basically enticing and make it okay for the staff to come and pay some attention to your message along with the physician so we were given a very very large budget and at the time I had mostly a rural area that serviced and I just I couldn't possibly spend all of the money that they kept allocating for for us to spend and and in yellow everything is measurable my numbers by quarter were fine and so I just got to a point where I realize I had all this entertainment money and I didn't really see the reason to just keep buying snacks and things that people wouldn't necessarily need or enjoy the office so I started going and buying just bulk numbers of hamburgers and going to Port Said the town both in Ardmore and Wichita Falls pulling up in my little company issued Jeep liberty opening up the back and and handing out hamburgers and the weird thing that happened there was one day I advised I think 47 hamburgers from the two frogs Grill in Ardmore Oklahoma and I drove to the east side Oklahoma there's a great guy up there in the town's name is Dr. for and I'd Artie been by's office earlier that day but he saw me and he saw me with a bunch of Styrofoam boxes handing it out to people in Ardmore and he stop mePsalms it will be doing Antonella handing out hamburgers that is what one over somebody who is more altruistic he liked the fact that I was taking the money and he knew that most physicians know it's a simple entertainment budget and you're doing it to gain the attention of somebody are hoping will recommend your product produce sales but when I was really doing was I just saw surplus and I thought there's no way could benefit from this better than somebody just truly hungry today so I bought a bunch hamburgers and handed them out and it turned out that through just dumb luck in turning to be a great sales pitch for me doing the right thing eventually pays on a daily basis and has one thing yeah and you know we took we talked about this that everything is still an industry it's still businesslike I said these people get their products out there and they have to get in front of doctors and when we launched our trunk heel I try to get production right away complain that sandbox right way too expensive so you we learned our lesson that Lorena let them do that but PeopleSoft make money for instance Platelets that sandbox were plain on spoony radio so go to love my tummy.com/spoony put in the code spooning SP 00 NY of an supports companies like upfront to heal so that you know we eventually can start doing some of this natural research when you are asking earlier about why you think there's this shift what you think Chris Kress are in the compressor Institute and the Cleveland clinic in Mark Hyman and all these people and Dave Asby are gaining so much traction talking about this kind of stuff and I think it's because a great example when I was a resident I was working a geriatric clinic and people would come in and every time they go see a doctor so if they're sitting there and they have no five or six doctors every doctor just given a drug they go so is it geriatricians are spent three years working in geriatric clinic I would look at their meds and go don't take that don't take that hill… When you're 95 years old and are on so many pills so many pills so I think that people get very frustrated that they go to the doctor the Department of medicine and they're not getting the results of because of the Internet and the information that is available like shows like this like shows like Brody talked about Chris Presser showing thing Bob.Rob good people are becoming important chair so it's no longer on just go do it what my doctor says that's why there is this movement dysfunctional health slide so excited about this member box that were good it would be you brought some accounting interesting earlier neat and he said that that the FDA's purpose there with that drug research is to make certain that the drugs most of our foremost aren't harmful but then there's an element where they had to show a little bit of efficacy what was the funny realization that you found it happens in the pharmaceutical or medical side for a drug to get approved for to be recognized is making a difference over placebo versus what you are able to do with a natural product before you even branded it and you realize I has something that's different it's already safe but it's actually making a difference so in my space in the gastrointestinal space when you have a disease called like irritable bowel syndrome with the bloating and change in bowel habits a lot of the drugs that are available even drugs that I like to get pulled off the market share after they found them to be unsafe like Zelnorm everything is around 9 to 10% better than placebo and the really expensive and so when we started figuring out natural ways to fix people were having better results mean the reality is we can get 4 to 5 people feeling better if you have the right symptoms in its natural cheaper it's affordable so whenever I think of anything is it available is it affordable is it affected those are the three things will be FDA's main goal is are you going to cause harm right that's what they're really being paid for are you going to cause harm not so much Arrigo determined that this is a very effective product Ricoh make sure you can hurt people and that's under drugs come around I was looking at the an article written get into that in the next hour because I think one of the things we can really talk about a lot is CBD cannabidiol the inner cannabinoid system and get into that and talk about how that inner plays with certain diets but as it turns out the pharmaceutical industry is really trying to get involved with that industry shredder figure out how to manipulate different enzymes one of the problems that we see all the time is that mother nature will do something and then the farm industry will need to have a patent and so they have to extract and manufacture a molecule and then put a drug name to it and say this is going to do this and we've seen that time and time again without question when pharmaceutical companies what I'm learning in the functional spaces mother nature since the do little bit better with right diet you take a whole client you take the whole molecule and not try and mess it up your body will figure out what to do with it work better than work but a great example a great example is that the Mediterranean diet for instance sure is filled with molecules called polyphenols follow polyphenols make vegetables colorful that make fruits colorful when you eat these polyphenols are poorly absorbed but they go to your colon where your own micro biome if you have a healthy micro biome will break down these molecules into beneficial anti-inflammatory antiaging molecules called Euro Lutherans and different things like that were learning more and more about that you cannot reproduce that with the drug right now because it's so complex were working with scientists down in South America and I there are several PhD's of come up and we go out to dinner and talk there like it is these micro biome or doing things that we can never reproduce in the lab is very deep it's really deep really deeply so and you know when you when you talk about pharmaceutical industry does tomatoes isolate that that's that's again they been doing for quite some time you hit on the fact that I had some experience in that pharmaceutical side I can still remember when they when they launched Roseann and Roseann is melatonin but it's an isolated melatonin and they told us it would have 14 times the affinity to the MT 192 receptors to induce sleep and even though they thought that little isolate was the trigger and actually underperformed it didn't do it any better then home melatonin did that's why I don't find it anymore and I believe that's why think that we can start seeing this whole shift back if we can just find a company that can bring some validity to it so that people can walk into a doctor's office and go look this study did show this it's unbiased this is what came out this is what happened we need to start doing that and if you're costing more money because with the prove that it's third-party analyze we need to make sure that we team up with companies like examine.com or consumer labs.com and make sure that everything comes to the things that are certified NSF certified and so on so yeah I don't really get a little deep here on under that aspect of that's I'm so passionate about functional medicine because there is real hope people go to their doctor and they get told no try this antidepressant try this anxiolytic take this you'll be fine take this pain medicine when young this year were making our first appearance I believe it to the IBM conference will be in San Antonio of the functional medicine conference yeah that place is filled with physicians and it grows by number every year that are just in the same position that you are and we meet more and more than every year medical met MDs DO those who have been trained in med school how to deal with disease and situations and more more they find it doesn't just exist in the pharmaceutical answers there are things beyond that their natural diet sleep whatever related that are going to help my patients feel better and then look at the opioid crisis that were doing with did you see in the news today that a police officer did a stop the woman handed him something and it appeared to be some sort of affordable fentanyl now and needing dark in the cop on a traffic stop oh because of that TOD by touching it by touching that's ridiculous I know it's crazy and I hate to interrupt the ship Patrick but did you know that dads up the fish that are coming out of the Puget Sound are contaminated with opioids I guess it's not filtered out during water treatment process so it's it's crazy nuts it's fit no fish no floundering new finfish their head up if you want to double down you have yourself some puffer fish sushi yeah you go to the tocsin or the fat know it's going to get you you can catch all your fish with a narco net pay that's the end of the first hour of the get check project things were hanging out we will check up with you here in about five minutes is five and I guess this is the only 24 hour take anywhere platforms dedicated to food and fun career spoony Townhall.com, as the Senate debates the green new deal the biggest disagreement appears to be over exactly what is in the Democratic plan and say the bill seeks to turn the country into a socialist state minority leader Chuck Schumer and says those concerns are way overblown they exaggerate they tell Miss truths but Sen. Mitch McConnell says there's only one green thing about the green new deal the huge unprecedented pile of middle-class families money the Democrats are itching itching to grab McConnell's promising ascetic boat soon on the green new deal but I knew Capitol Hill former Florida police officer facing up to life in prison after being convicted in the fatal shooting of a black motorist whose car is broken down along an Interstate 41-year-old Newman Roger shot 31-year-old Cory Jones in October 2015 an American journalist detained in and then deported from Venezuela County windowless fleet several hours late and deported back to the US executives at his Miami-based TV station and union representatives went in hundred 24-1 in foyer's most recently working as a freelance stylist for ABC affiliate local 10 years in Miami correspondence area shackling KID says it's the worst she's ever seen the Alabama Gov. talking about the massive destruction caused by the tornadoes it pummeled Lee County last weekend is truly tragic is nothing but splint was left to think size all broken up you talk about the loss of buildings and homes and livelihoods shelf this is horrendous devastation the death toll in the small town of Beauregard stands at 23 heavy losses on Wall Street the downtown 232 points more on the stories@townhall.com mold is a better way take the pain out of ordering your diabetic testing supplies with diet Thrive diatribe ships the testing supplies you need directly to you when you need them best of all with plans starting as low as eight dollars a month diatribe is probably going to cost you less than what you're paying today diatribe is so convinced that you love their service they're offering your first month of supplies free simply type the Kodak DOC and checkout diet Thrive.com that's DIA Thrive.com never forgotten apparel is more than just the premium women's and men's clothing line it's a movement to remind us to wear American-made and serve those who serve us our heroes never forgotten apparel gives 20% of their total sales to nonprofits that support homeless veterans and off-duty firefighters and 50% to individual veterans and firefighters in need nationwide checkout never forgotten apparel.com use promo code Matt and ATT and get 15% off your purchase have you done it did you catch a glimpse of yourself in the mirror I'm I'm one of those people you don't want to see naked IBM most of us but I mean you look in your gonna die I know I get to whatever you call it's horrible hey that's Doc Townsend and Brad Staggs to tell you about a different way to shed those pounds this is brand-new technically been around for a couple years or so it was based on research from the University of California that said there is a molecule called OEA that's found naturally in your body produces it in the Mediterranean diet that when taken concentrated amounts it will actually make you feel fuller and boost your metabolism I lost about 10 pounds so far is a mere amazing ballet school company said we can take this to market to make this great product that will help you it's called grid you zone our IDU zone.com are IDUs zone.com Brad's work does work for Brad's work for me countless other people go to read you zone.com and try today you're going to love it read you zone.com remember that our IDU zone.com all rights back for our number two they have not kicked us off the gut check project try design will receive the over under I'm seeing these guys exchange money over here I buy yeah I got a 14 seconds hey I just heard an ad for rigid zones like we did the last half hour and the person doing that live raid was the late Doc Thompson want to give a big shout out to him and do all of the crew here at spoony Patrick Ron Tom thank you so much for having us this is when I was in the books is been a lot of fun so far is a lot of fun and this is this is one of the essays will reset in the last hour the rising tide lifts all ships I really want to see these guys succeed there the really busted the tail to get out there something more important in a state if the people I see what you look like you know I met the frog is very handsome but I think that appreciating the TV as well you can get a Facebook and go to this many radio paging that I turn to page and it streaming live there and I going watch the video like it – it's pretty fun not to mention Nicholas on speaker and also in iHeartRadio dealership Patrick I think is good there we were just talking between the sets about how to get more views and you imagine more nudity and Shepherd has the air America was a male model so was the nudity our CEO texted me and said thanks the Shanna Fisher mention my last name so shout out check Scott because when I think of validity I think I just got there we go yeah that's yet he shows A lot in all seriousness we do want to get back a little bit on-topic in terms of what were trying to do here for our first ever got check project and that is basically laid on the format what we can expect whenever you tune in each week to get a project because this this banter course you you may see both as you will almost always see Dr. Brown it is not going to be the cornerstone we will have some great guests on we will be talking about a bunch of the great topics from everything from research with stem cells to how to exercise to the cannabis industry to polyphenols to on and on and on various topics but today were going to basically let you put a strong idea in terms of who is Dr. Kenneth Brown and why is it that he's he's doing that so we left the last half hour talking little bit about bridging the gap between natural and medical science and is removed to the next half hour let's talk a little bit about what it means to examine some other serious systems that have been somewhat ignored in the body namely the ECS the Indo cannabinoid or cannabinoid system however you Mr. Burnett set tomato tomato so what do you want to say briefly you what we were talking and your super comfortable for Mike, I'm a little more nervous than the stuff I actually a background for me as a child I started growing up so being TV and radio and stuff so stressful but is really cool that your talk about what your dad taught you because your dad was in radio was yeah and unfortunately he died two years you yesterday to have your so shut out to him as payment cycle kept him everybody but he knew my dad loved and he was those who knew him quite well and we give a yeah good little moniker that he always said which is hey guys so for those who they knew him they they know that he did it take you to the radio station your tips well reluctantly asked that I like to put my hands on the turntables and I think that he was that each identity that too much but yeah he went to the radio station several times my dad my dad was in the meat rendering process so he would take me and I could play with the kidneys of cows why am I doing this he lead you to where you were when I was holding organs introducing you to the endocrine system of the renal cyst of an animal that's what you're playing with that the when I when I was a medical school it universe Nebraska they really want an oppressed family practice doctors to go to rural communities trip and so I spent three months at a rural community where the main industry was meatpacking and injuries what happened in these doctors were overworked and I'm 1/3 year med student and stuff that would come in I look back on that I just go hold the child that's a rough one it was rough yeah I am I remember were to get back to the CSO is a cool stuff but perhaps get to know us that share where I come from now Alecto not meet there were some of me to talk about meatpacking and Ike I speak Spanish in the very first hour mention my wife's Puerto Rican my mother's Argentinian we speak were bilingual home and I was working the emergency room Lexington Nebraska a woman came in pregnant water broke and I called the doctrine: is like I want to weigh in is a true visit and he said the name is like a loose liquor a schedule talk you through is like I'll be there doorbell major she's got this down if it happens before and she did she talk me through wash your hands and just like your mask is on backward camera.your names can let you cry but she didn't have an accident but that's is the one I defaulted so we did and that's what you're saying so props your dad prompted our Thompson proxy had add props to everyone that has taught us anything sure because it's got check radio or get your project is a project and we check our egos at the door and we just learn from everybody we did that's our goal so the ECS so we've we've heard of the digestive system we heard about the nervous system the skeletal system renal lung pulmonary whatever you want to call it why is the ECS new or is it new to us this is one of those things where you walk up and props to Christine Thiel of Alexa and all and Gabriel CEO Prolixin all for grabbing me and making me listen and not by me lunch and not taking me on a trip like you know we've I've had done with farm industries sure just call me out general information you need to know this and they threat a bunch of information like vomiting it was overwhelming and now I know why it is because we have discovered a system in our bodies called the Endo cannabinoid system the throughout your entire body but the reality is if you would think it and really simplify it links the immune system to the nervous system and right there two circles coming together that's where the ECS lives so although it does all kinds of crazy things if you have anything on your brain meaning anxiety all the way from anxiety to seizures it just sort of controls it and calls it down it's a traffic cop if you have anything in nerves like diabetic neuropathy or if you've got sciatic pain pain pain inwardly writing about this on KPMG health.com sure lots because I'm so blown away that I feel like I've been gifted the ability to learn about a system that now my colleagues know about our elaborate on that just a little better because you said were going to be writing about it but I do want to draw a good distinction here and not that other people don't put in the time for research because there's a lot of people after the do it but I will say that if if Dr. Brown it can end up putting any element into a level research to have something written it's because it's actually happened everything that you've done as long as I've known you is well I've read this about it let's find out if that's true and so that's really what KB MD health is all about is basically to spread the information good or bad about how something does may or may not work and so is is that something that you found somewhat inspiring to be able to dig in deep whenever you first started working with the CBD you if our member correctly like arms can see this works and find out what happens yeah so the first so what ended up happening is three years ago was appellee or fax which is conference I like in Austin and I was walked by the elixir tollbooth I got grabbed and I was being support information didn't know anything about it and I love the passion sure someone one thing that I will will always be drawn to his passion and so if you're passionate about anything those things I don't know about and working to bring those experts here yeah order bring essential oil exports and because I know about it and I want to learn and it says Snyder right is a essential oil exports just published a book on that were to bring probably her into talk about it because we want to sit there and make sure they were not leaving any stone unturned but there's only so much time in t
Hellenia Healthfoods have been chatting about their new product, Polyphenol 5, which can fill in the gaps of nutrients in your diet that we need from fruit and vegetables.
Worry about dementia, Alzheimers, or losing your memory? Or do you just want to improve your brain function? Discover the best brain food and the MIND diet with Maggie Moon. PLUS: Learn how to win The MIND Diet book! ON THE SHOW: Statistics: 5.5 million Americans have Alzheimer’s 47 million Americans have some evidence of cognitive impairment The MIND Diet is a combination up of: The Mediterranean Diet, and The DASH Diet What is the best brain food to eat? Adding foods, rather than deprivation What are some world cuisines that fit the MIND Diet? Which foods should you minimize? Why are some components of good brain food? Polyphenol antioxidants B vitamins Omega 3’s synergistic effects lutein Important brain food / MIND Diet questions answered: When can wine be helpful? What about the mercury in fish? What about eggs? Where does chocolate fit in the diet? How to overcome obstacles to following the MIND diet? How to make the diet easy? What does The MIND Diet book cover? How to win drawing The MIND Diet book. Tag a friend (who you think might be interested) on our Facebook post about this episode: (https://www.facebook.com/pg/MaryPurdyRD/posts/) Each friend tagged will count as one entry for our drawing. The book winner will be drawn at random and announced on our next show. We can only send the book to a US address. AND... The Nutrition Challenge of the Week! Maggie Moon, MS, RD: Author of The MIND Diet Learn more about Maggie at maggiemoon.com Check out her recipes at minddietmeals.com The MIND Diet, available on Amazon and everywhere they sell books. https://www.amazon.com/MIND-Diet-Scientific-Enhancing-Alzheimers/dp/1612436072 Say hello to Maggie on Instagram, Facebook, Twitter and Pinterest @minddietmeals ABOUT THE SHOW Mary Purdy, MS, RDN, dishes out easy-to-digest info, tips, and advice about nutrition & lifestyle, backed by over 10 years of clinical experience and a healthy sense of humor. Please Subscribe, Rate, and Review on Podcasts App (or iTunes) https://itunes.apple.com/us/podcast/marys-nutrition-show/id1245983321 ABOUT MARY Mary Purdy is a Registered Dietitian with a Masters in Clinical Nutrition from Bastyr University. Past experience: • Private practice (8 yrs) • Adjunct professor at Bastyr University • Clinical Supervisor at Bastyr Center for Natural Health. Mary currently works as a Registered Dietitian Coach at the Scientific Wellness company, Arivale. Mary takes an integrative/holistic approach to diet, health & wellness and believes that food is medicine! Mary’s Nutrition Show is on Amazon’s Alexa You can say: “Alexa — enable Mary’s Nutrition Show.” https://www.amazon.com/Wizzard-Media-Marys-Nutrition-Show/dp/B07BSW4JQ8/ Mary has a new website! http://marypurdy.co/ Mary’s (free) Quick Start Guide to Nutrition http://marypurdy.co/quick-start-guide-sign-up/ MARY’S NEW BOOK: http://marypurdy.co/book/ MARY’S VIDEOS: https://www.youtube.com/marypurdy DISCLAIMER This podcast is intended for entertainment purposes only. Please consult your doctor before following any information you hear here. The opinions expressed here are those exclusively of Mary Purdy, the Show’s producers, and guests, and do not necessarily represent the views of Arivale, Bastyr, Dietitians in Integrative and Functional Medicine, or other entities.
Check out our new website! https://www.minuteearth.com/ Thanks to Squarespace for sponsoring this video. http://www.squarespace.com/minuteearth Thanks also to our supporters on https://www.patreon.com/MinuteEarth Astringent plant chemicals called tannins bind proteins on mucous membrane and skin, generating a prickly, puckery mouthfeel from foods and letting us “tan” skins into leather. ___________________________________________ If you want to learn more about this topic, start your googling here: Tannin: a yellow or brownish chemical present in some plant tissues, used in leather production and ink manufacture, and a contributor to the sensation of astringency Astringency: the sensation caused by the contraction of body tissues due to tannins, often called “mouthfeel” Polyphenol: a chemical compound containing more than one phenolic hydroxyl group, of which tannins are a major group Phenolic: a chemical compound with a hydroxyl group (oxygen & hydrogen) linked directly to a benzene ring ___________________________________________ Credits (and Twitter handles): Script Writer: Alex Reich (@alexhreich) Script Editor: Kate Yoshida (@KateYoshida) Video Illustrator: Ever Salazar (@eversalazar) Video Director: Henry Reich (@MinutePhysics) Video Narrator: Emily Elert (@eelert) With Contributions From: Peter Reich, David Goldenberg Music by: Nathaniel Schroeder: http://www.soundcloud.com/drschroeder _________________________________________ Like our videos? Subscribe to MinuteEarth on YouTube: http://goo.gl/EpIDGd Support us on Patreon: https://goo.gl/ZVgLQZ And visit our new website! https://www.minuteearth.com/ Also, say hello on: Facebook: http://goo.gl/FpAvo6 Twitter: http://goo.gl/Y1aWVC And find us on itunes: https://goo.gl/sfwS6n ___________________________________________ References: Bajec, M. R., & Pickering, G. J. 2008. Astringency: mechanisms and perception. Critical reviews in food science and nutrition, 48(9), 858-875. https://goo.gl/XLR0JY Barbehenn, R. V., & Constabel, C. P. 2011. Tannins in plant–herbivore interactions. Phytochemistry, 72(13), 1551-1565. http://www.sciencedirect.com/science/article/pii/S0031942211000690 Covington, A. D. 1997. Modern tanning chemistry. Chemical Society Reviews, 26(2), 111-126. http://pubs.rsc.org/en/content/articlehtml/1997/cs/cs9972600111 Covington, A. D. 2009. Tanning chemistry: the science of leather. Royal Society of Chemistry. Covington, A., Mar 2017, personal communication. Gawel, R. 1998. Red wine astringency: a review. Australian Journal of Grape and Wine Research, 4(2), 74-95. http://onlinelibrary.wiley.com/doi/10.1111/j.1755-0238.1998.tb00137.x/full Lesschaeve, I. & A.C. Noble. 2005. Polyphenols: factors influencing their sensory properties and their effects on food and beverage preferences. The American journal of clinical nutrition 81, no. 1: 330S-335S. http://ajcn.nutrition.org/content/81/1/330S.full Siebert, K., Mar 2017, personal communication.
Dr Robert Thomas talks to ecancer at the 2013 NCRI Cancer Conference in Liverpool about a polyphenol food supplement that has been shown to slow the spread of prostate cancer. Polyphenol rich foods such as pomegranate, green tea, broccoli and turmeric have demonstrated anti-neoplastic effects in cell lines and animal models, including anti-angiogenesis, pro-apoptotic and reduced proliferation. Some have been investigated in small phase II studies. This study found a statistically significant, favourable effect on the percentage rise in PSA in this cohort of men with prostate cancer. Future trials will look at the longer term clinical effects and the benefits for men receiving ADT.
Dissemination of metastatic cells probably occurs long before diagnosis of the primary tumor. Metastasis during early phases of carcinogenesis in high risk patients is therefore a potential prevention target. The plant polyphenol Curcumin has been proposed for dietary prevention of cancer. We therefore examined its effects on the human breast cancer cell line MDA-MB-231 in vitro and in a mouse metastasis model. Curcumin strongly induces apoptosis in MDA- MB- 231 cells in correlation with reduced activation of the survival pathway NF kappa B, as a consequence of diminished I kappa B and p65 phosphorylation. Curcumin also reduces the expression of major matrix metalloproteinases (MMPs) due to reduced NF kappa B activity and transcriptional downregulation of AP-1. NF kappa B/p65 silencing is sufficient to downregulate c-jun and MMP expression. Reduced NF kappa B/AP-1 activity and MMP expression lead to diminished invasion through a reconstituted basement membrane and to a significantly lower number of lung metastases in immunodeficient mice after intercardiac injection of 231 cells (p=0.0035). 68% of Curcumin treated but only 17% of untreated animals showed no or very few lung metastases, most likely as a consequence of down-regulation of NF kappa B/AP-1 dependent MMP expression and direct apoptotic effects on circulating tumor cells but not on established metastases. Dietary chemoprevention of metastases appears therefore feasible. Copyright (c) 2007 S. Karger AG, Basel.
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