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Asian American History 101
A Conversation with Award-winning Educator, Researcher, and Author Gordon H Chang

Asian American History 101

Play Episode Listen Later Jul 21, 2025 48:30


Welcome to Season 5, Episode 29! Today we're joined by a true icon in the world of academia—Professor Gordon H. Chang. A celebrated historian, Professor Chang is both the Olive H. Palmer Professor in Humanities and a Professor of History at Stanford University. He's also a member of the American Academy of Arts and Sciences. We're honored to speak with him about his latest book War, Race, and Culture, published by Stanford University Press in May 2025. This anthology compiles some of his most powerful essays written over decades of impactful scholarship. The topics range from foreign relations and U.S. imperialism to race, Asian American identity, and the cultural contributions of Asian Americans. Our conversation covers everything from the role of propaganda in shaping views of Asians, the long history of harmful stereotypes, and the cultural erasure seen during Japanese internment—including how artists like Dr. Seuss and creators of Superman contributed to racist narratives. Professor Chang also reflects on the political engagement of Asian Americans and why “nurture vs. nature” plays a crucial role in debunking the myth of political apathy in the community. We also touch on a more personal subject: his interest in art history, including how his father's legacy inspired him to explore and uplift overlooked Asian American artists like Dong Kingman, whose brilliance was too often overshadowed by the racist caricatures found in mainstream media. This episode offers not only a look into Professor Chang's new book, but a deeper understanding of how history, race, and culture intersect in America—and why writing history is always personal. Links and Resources: Learn more about War, Race, and Culture from Stanford University Press Read more from Gordon H. Chang, including Ghosts of Gold Mountain, Fateful Ties, and Asian American Art: A History, 1850-1970 If you like what we do, please share, follow, and like us in your podcast directory of choice or on Instagram @AAHistory101. For previous episodes and resources, please visit our site at https://asianamericanhistory101.libsyn.com or our links at http://castpie.com/AAHistory101. If you have any questions, comments or suggestions, email us at info@aahistory101.com.  

The Cloudcast
Should you join an AI Startup?

The Cloudcast

Play Episode Listen Later Jul 20, 2025 22:16


If the rewards of a startup are only going to the founders and AI researchers, then what incentives are there for all the other roles? Has AI broken the startup model? SHOW: 942SHOW TRANSCRIPT: The Cloudcast #942 TranscriptSHOW VIDEO: https://youtube.com/@TheCloudcastNET CLOUD NEWS OF THE WEEK: http://bit.ly/cloudcast-cnotwCHECK OUT OUR NEW PODCAST: "CLOUDCAST BASICS"SHOW SPONSORS:[FCTR] Try FCTR.io (that's F-C-T-R dot io) free for 60 days. Modern security demands modern solutions. Check out Fctr's Tako AI, the first AI agent for Okta, on their website[VASION] Vasion Print eliminates the need for print servers by enabling secure, cloud-based printing from any device, anywhere. Get a custom demo to see the difference for yourself.[DoIT] Visit doit.com (that's d-o-i-t.com) to unlock intent-aware FinOps at scale with DoiT Cloud Intelligence.SHOW NOTES:Google and Windsurf, Stinky Deals, Chesterton's Fence and the Silicon Valley EcosystemAndreessen Horowitz's Casado Plays Talent Broker for CursorCognition acquires Windsurf after CEO and Researchers go to GoogleAre AI Acquihires Screwing Up the Startup Space?How ‘Acquihires' Are Reshaping Silicon Valley's AI InvestmentsWHY WOULD ANYBODY JOIN AN AI STARTUP? Windsurf, ScaleAI, Inflection and several other AI companies are getting acquihired. The US DOJ and FTC are scrutinizing acquisitions by large tech companiesLarge tech companies are able to acquihire without paying for non-foundersNot every company will be ChatGPT and grew without massive sales and marketingWhat would anyone join an AI Startup if you're not the Founder or AI Researcher? FEEDBACK?Email: show at the cloudcast dot netTwitter/X: @cloudcastpodBlueSky: @cloudcastpod.bsky.socialInstagram: @cloudcastpodTikTok: @cloudcastpod

The Science Show -  Separate stories podcast
Power from the motion of the ocean

The Science Show - Separate stories podcast

Play Episode Listen Later Jul 19, 2025 13:00


A wave energy generator trial has been running at Albany on WA's south coast. Researchers say these offshore devices, if scaled up, could be a useful source of renewable power. 

The 365 Days of Astronomy, the daily podcast of the International Year of Astronomy 2009

Researchers have determined how to effectively measure the magnetic fields at Neptune to determine if any of the moons are ocean worlds… in just twelve minutes. Plus, lasers recreate galaxy cluster conditions, some mind-bending new math, how the Earth's crust developed, and a look at the long history of Daylight Saving Time.   We've added a new way to donate to 365 Days of Astronomy to support editing, hosting, and production costs.  Just visit: https://www.patreon.com/365DaysOfAstronomy and donate as much as you can! Share the podcast with your friends and send the Patreon link to them too!  Every bit helps! Thank you! ------------------------------------ Do go visit http://www.redbubble.com/people/CosmoQuestX/shop for cool Astronomy Cast and CosmoQuest t-shirts, coffee mugs and other awesomeness! http://cosmoquest.org/Donate This show is made possible through your donations.  Thank you! (Haven't donated? It's not too late! Just click!) ------------------------------------ The 365 Days of Astronomy Podcast is produced by the Planetary Science Institute. http://www.psi.edu Visit us on the web at 365DaysOfAstronomy.org or email us at info@365DaysOfAstronomy.org.

Foreign Podicy
Schools for Scandal

Foreign Podicy

Play Episode Listen Later Jul 18, 2025 67:52


Woke ideology, anti‑Americanism, Islamism and antisemitism have gripped America's elite campuses. How? Follow the money.Researchers at the Middle East Forum have been doing exactly that, and the result is a new report that's shocking but not surprising. It's titled: “Beachhead: Georgetown University: How Foreign and Domestic Radical Actors Captured a U.S. University.”Host Cliff May is joined by his FDD colleague Brandy Shufutinsky and report co-authors Asra Q. Nomani and Sam Westrop to discuss the Gulf autocrats and Saudi‑linked SAFA network pouring millions of dollars into Georgetown's Al‑Waleed Center, warping future diplomats and even infiltrating K‑12 classrooms—and the actions that must be swiftly taken by policymakers to solve it.Sam WestropSam Westrop is an expert on nonviolent Islamist networks and has headed the Middle East Forum's Islamist Watch project since March 2017. He previously ran Stand for Peace, a London-based counter-extremism organization that monitored Islamist movements throughout the UK and which guided British policy on terror finance and violent extremism. Combining open-source research with big data coding and scraping, his investigative work in the United States on the financial activities of seven leading Islamist movements active across America has sparked multiple congressional inquiries, generated law enforcement investigations, and effected federal policy changes.Asra NomaniAsra Q. Nomani is an investigative reporter, journalist, private investigator, author, educator, editor and former reporter for the Wall Street Journal. She is founder of the Pearl Project a nonprofit initiative dedicated to doing journalism in the public interest, defending press freedoms and preserving the legacy of a great journalist and friend. Asra is widely recognized for rational commentary, analysis and advocacy work across a diversity of issues and media platforms, including MSNBC, CNN, Fox News, the Washington Post, the New York Times and BBC, among others.Brandy ShufutinskyBrandy Shufutinsky serves as director of FDD's Program on Education and National Security. Prior to joining FDD, Brandy was director of education and community engagement at the North American Values Institute. Brandy has been published in Newsweek, Jewish Journal, The Jerusalem Post, Sapir, White Rose Magazine, and JNS. She was a 2021 scholar-in-residence at the Institute for the Study of Global Antisemitism and Policy Oxford Summer Institute, where she worked to develop curriculum in critical antisemitism studies.

SpaceTime with Stuart Gary | Astronomy, Space & Science News
Dark Dwarfs and Lunar Insights: The Youngest Meteorite and New Discoveries in the Carina Nebula

SpaceTime with Stuart Gary | Astronomy, Space & Science News

Play Episode Listen Later Jul 18, 2025 23:34


In this episode of SpaceTime, we explore the latest discoveries in lunar geology, the intriguing concept of dark dwarves, and the stunning features of the Carina Nebula.The Youngest Basaltic Lunar MeteoriteScientists have uncovered a 2.35 billion-year-old lunar meteorite, Northwest Africa 16286, which fills a significant gap in our understanding of the Moon's volcanic history. This meteorite, distinct in its chemical profile, suggests that volcanic activity on the Moon persisted longer than previously thought, unveiling new insights into its internal heat generation processes. Lead author Joshua Snape from the University of Manchester explains how this rare sample enhances our knowledge of lunar geology without the costs associated with space missions.Hypothetical Dark Dwarfs and Dark MatterA new study proposes the existence of hypothetical objects called dark dwarves, which could help unravel the mystery of dark matter—an invisible substance that constitutes approximately 80% of the universe's mass. Researchers suggest that these low-mass objects could interact with dark matter in ways that produce observable effects, providing a potential pathway to understand this elusive component of the cosmos. The study highlights the importance of identifying markers, such as lithium-7, to confirm the existence of dark dwarfs and advance our understanding of dark matter.Adaptive Optics and the Carina NebulaUsing adaptive optics, astronomers have achieved unprecedented clarity in imaging the western wall of the Carina Nebula, revealing intricate structures previously hidden by dust and gas. This breakthrough allows for a deeper investigation into star formation processes in this massive stellar nursery. The enhanced images showcase how massive young stars influence their surroundings and contribute to the cycle of stellar life, offering a glimpse into the conditions that may have shaped our own solar system.www.spacetimewithstuartgary.com✍️ Episode ReferencesJournal of Cosmology and Astroparticle Physicshttps://www.journalofcosmology.com/Nature Journalhttps://www.nature.com/natureBecome a supporter of this podcast: https://www.spreaker.com/podcast/spacetime-space-astronomy--2458531/support.00:00 00:49 04:51 09:17 15:16 17:08

Fronteras
Researchers give voice to immigrant families, break down the costs of being undocumented

Fronteras

Play Episode Listen Later Jul 18, 2025 26:04


Researchers aim to humanize immigrants by sharing their stories.

Earth Wise
A recycling lottery

Earth Wise

Play Episode Listen Later Jul 18, 2025 2:00


Getting people to recycle isn't always easy.  The bottled beverages we buy at the supermarket often require a small deposit that we can get back by recycling the bottle, but often, we just don't. Researchers from the University of British Columbia tested the idea of giving people returning bottles a small chance of winning a […]

Chicago's Afternoon News with Steve Bertrand
Dr. Igor Koralnik on the viral link to Parkinson's: Northwestern study uncovers breakthrough

Chicago's Afternoon News with Steve Bertrand

Play Episode Listen Later Jul 18, 2025


Dr. Igor Koralnik of Northwestern Medicine joins the Lisa Dent Show to discuss a major discovery: Researchers have found human pegivirus (HPgV) in the brains of Parkinson's patients, a potential clue to the disease's mysterious origins.

Fred + Angi On Demand
Fred's Biggest Stories of the Day: TSA Changes, GLP1 Positive Side Effects, President Trump Convinced Coca Cola, Mouse in Monster Energy Drink, & Haunted Doll!

Fred + Angi On Demand

Play Episode Listen Later Jul 17, 2025 15:58 Transcription Available


TSA has quietly changed the checking the shoes policy and is thinking about changing the liquid rule. Researchers believe that GLP1 medications could help prevent dementia. President Trump claims that he has convinced Coca Cola to use cane sugar in their beverages. A Michigan woman is suing Monster Energy because she claims she found a mouse in her energy drink. The doll handler for Annabelle the haunted doll is dead and the doll is currently missing.See omnystudio.com/listener for privacy information.

The Gateway
Thursday, July 17- Baby teeth link Coldwater Creek to cancer

The Gateway

Play Episode Listen Later Jul 17, 2025 10:28


Researchers at Harvard University have used participants from a decades-old study of baby teeth to link those who lived near Coldwater Creek in north St. Louis County to increased cancer risks. The study offers the latest evidence for what residents have insisted for decades: that exposure to certain sites has made people sick.

RNZ: Checkpoint
Researchers want formal inquiry as Campylobacter rates shoot up

RNZ: Checkpoint

Play Episode Listen Later Jul 17, 2025 4:02


A group of NZ researchers want a formal inquiry into the rates of Campylobacter infection. In a just-released study, hospitalisation rates for Campylobacter infection have increased by almost 70 percent in 17 years. Most of the time, the source of the illness is contaminated fresh chicken meat. The group of prominent public health researchers behind the research say rising hospitalisation rates are a serious concern and want urgent action from the government. Jessica Hopkins reports.

Elon Musk Pod
Former OpenAI and Anthropic Staff Accuse Elon Musk's xAI of Ignoring AI Safety Warnings

Elon Musk Pod

Play Episode Listen Later Jul 17, 2025 10:52


Former researchers from OpenAI and Anthropic are calling out xAI's approach to AI safety.The team behind Grok allegedly ignored internal warnings and sidelined staff who raised concerns.Grok has generated antisemitic and conspiratorial responses on X, prompting further scrutiny.Internal sources say Grok was trained using user data from X without consent.Safety evaluations were reportedly skipped or dismissed to speed up product rollout.Researchers pushing for safeguards were removed from key projects or left the company.An open letter signed by multiple AI researchers demands legal protections for whistleblowers.Current U.S. law lacks clear protection for employees disclosing AI-related risks.Musk's stance favors fewer restrictions, calling Grok “uncensored” compared to rivals.The controversy raises pressure for regulation and transparency in high-risk AI development.

Total Information AM
Study of baby teeth leads researcher to Coldwater Creek nuclear contamination

Total Information AM

Play Episode Listen Later Jul 17, 2025 3:22


Doctor Marc Weisskopf is Cecil K and Drinker Professor of Environmental Epidemiology and Physiology at Harvard T.H. Chan School of Public Health, he reached out to Just Moms S-T-L founder Dawn Chapman who explained the study to KMOX's Maria Keena.

babies news study leads public health researchers physiology babyteeth kmox coldwater creek environmental epidemiology dawn chapman nuclear contamination
IT Privacy and Security Weekly update.
EP 251.5 Deep Dive,. The IT Privacy and Security Weekly Update, with a side of Fries, for the Week Ending July 15th., 2025

IT Privacy and Security Weekly update.

Play Episode Listen Later Jul 17, 2025 14:38


Significant Data Breaches and VulnerabilitiesMcDonald's AI-driven hiring platform, Olivia (by Paradox.ai), exposed 64 million applicant records due to weak security, including a password as simple as "123456." In Sweden, security personnel inadvertently revealed Prime Minister Ulf Kristersson's whereabouts by sharing fitness routes on Strava. Qantas suffered a breach affecting 5.7 million customers, with personal details like addresses and phone numbers exposed via a third-party platform compromised by the Scattered Spider group. These cases demonstrate the risks of inadequate security in automated systems and third-party integrations.Skepticism Around Jack Dorsey's Bitchat AppJack Dorsey's Bitchat, a decentralized messaging app using Bluetooth and end-to-end encryption, faces skepticism due to its lack of external security audits. Researchers identified flaws, such as a broken identity verification system enabling impersonation. Dorsey's warnings on GitHub advise against using the app until properly vetted, raising concerns about premature launches of privacy-focused tools.“Contagious Interview” AI-Powered ScamThe “Contagious Interview” scam, linked to North Korean hackers, targets job-seekers on platforms like LinkedIn. Posing as recruiters from fake companies (e.g., BlockNovas LLC), hackers use AI-generated personas and fake profiles to trick victims into installing malware disguised as interview tools. This malware, including BeaverTail and InvisibleFerret, steals passwords and cryptocurrency data, showing the potent combination of AI and social engineering in cybercrime.Quantum Computing Threat to EncryptionQuantum computing's rise threatens current encryption methods like RSA and ECC, posing risks to data security in industries like finance and healthcare. Experts recommend adopting post-quantum cryptography (PQC) by inventorying encryption-reliant systems, requiring vendors to provide PQC migration plans, and updating firmware to quantum-resistant signatures to protect against future decryption threats.OpenAI's Challenge to Productivity SoftwareOpenAI is poised to disrupt Microsoft 365 and Google Workspace with an AI-powered productivity suite. Leveraging generative AI, it offers collaborative writing, editing, brainstorming, and graphics assistance, potentially at a lower cost than Microsoft's Copilot. This move signals a shift toward AI-driven productivity tools, challenging established market leaders.xAI API Key LeakA DOGE employee, Marko Elez, accidentally exposed an xAI API key on GitHub, granting access to over 52 AI models, including grok-4-0709. Elez's role in DOGE, with access to sensitive U.S. government data, amplifies the risk. The unrevoked key and prior DOGE leaks suggest systemic security negligence, endangering AI models and government data.Cybersecurity TakeawaysThese incidents emphasize the need for robust cybersecurity in automated systems, thorough vetting of third-party platforms, caution with digital footprints (e.g., fitness apps), and external security reviews for new apps. Vigilance against AI-driven scams is critical, with users urged to verify sources and software.Broader Cyber Threat TrendsThe reliance on vulnerable third-party platforms, sophisticated AI-powered social engineering, internal security lapses, and the looming quantum computing threat demonstrate the need for proactive, future-proof cybersecurity strategies to safeguard sensitive data and systems.

Hashtag Trending
AI's Capabilities and Content Crisis: From Chess Challenges to Amazon's Strategic Moves

Hashtag Trending

Play Episode Listen Later Jul 17, 2025 11:55 Transcription Available


  In this episode of Hashtag Trending, host Jim Love delves into a series of AI-related stories. Google's Gemini AI withdraws from a chess match against an Atari 2600 chess engine after realizing its limitations. Researchers from MIT and EPFL identify a 'phase transition' in AI language models where they begin to understand semantics over syntax. The episode also highlights the growing issue of AI-generated 'slop,' which overwhelms content reviewers and dilutes quality across various fields. Lastly, Amazon's strategic investment in Anthropic is explored, focusing on infrastructure rather than consumer-friendly AI applications, potentially positioning Amazon as a key player in the AI revolution. 00:00 Introduction and Overview 00:27 Gemini AI vs. Atari Chess Challenge 02:15 AI's Leap to Understanding Meaning 05:38 The Rise of AI-Generated Content 08:49 Amazon's Strategic Investment in AI 11:22 Conclusion and Upcoming Shows

WTF Just Happened?!: Afterlife Evidence, Paranormal + Spirituality without the Woo
Renowned NDE Researcher Studied 5,000 Cases with Dr. PMH Atwater Episode 144

WTF Just Happened?!: Afterlife Evidence, Paranormal + Spirituality without the Woo

Play Episode Listen Later Jul 17, 2025 66:14


Guest: Dr. P. M. H. AtwaterFull Notes: Renowned NDE Researcher Studied 5,000 Cases with Dr. PMH Atwater Episode 144Dr. PMH Atwater is an international authority on near-death experiences. She has researched about 7,000 cases in a lifetime endeavor that covers over 43 years. She has even had her research published in the prestigious science journal The Lancet. She also had three of her own NDEs. Her work was first discovered by researcher Dr. Kenneth Ring. FULL BIO + SHOW NOTESJoin our Science + Spirituality CircleHost or Attend a Science + Spirituality SalonBuy the books: ⁠⁠WTF Just Happened?! SeriesFollow Dr. PMH Atwater: ⁠Website⁠ | ⁠YouTube⁠ | ⁠Colloids⁠ | ⁠Charts⁠**I hope to see you at the IANDS Conference!!**IANDS : INTERNATIONAL ASSOCIATIONAttend the Conference Support IANDS⁠⁠⁠Buy me a coffee⁠⁠⁠⁠ |⁠⁠ ⁠⁠WTF Just Happened Books⁠⁠ | ⁠⁠⁠⁠Science + Spirituality Salons⁠⁠ |⁠⁠⁠⁠Newsletter ⁠⁠⁠ |Patreon 

The Wright Report
16 JULY 2025: Trump Wants Epstein Documents // Good News: Mineral Wars, Tariff Wars, Energy Production, Inflation // Global News: Bombing Moscow, Killing Druze, and Saving Women in Norway With Breast Cancer

The Wright Report

Play Episode Listen Later Jul 16, 2025 29:21


Donate (no account necessary) | Subscribe (account required) Join Bryan Dean Wright, former CIA Operations Officer, as he breaks down today's biggest stories shaping America and the world. Epstein Case Reignites as Trump Calls for Transparency President Trump reverses course and says credible Epstein files should be released. This comes amid new analysis showing missing jail footage from the night Epstein died, raising fresh suspicions about foul play. House Democrats demand full disclosure, while Bryan calls out AG Pam Bondi for mishandling the case. Trump's Economic Agenda Delivers Wins on Minerals, Trade, and Energy The Pentagon and private firms like Apple ramp up investment in U.S. rare earth minerals to cut dependence on China. Trump signs a new trade deal with Indonesia requiring $20 billion in U.S. imports and cooperation to stop Chinese transshipment. Meanwhile, tech giants pledge $56 billion for new AI centers in Pennsylvania, driving demand for nuclear, hydro, and grid expansion. Inflation Holds at 2.7% Amid Questions Over Federal Data Accuracy June's CPI report shows mild inflation, suggesting tariffs aren't yet hitting consumers. But 35% of prices were estimated, not observed. Fueling concerns the Fed may be basing decisions on faulty data. Bryan warns this could keep interest rates unnecessarily high. Trump Tactics with Russia: Escalate to De-Escalate Trump reportedly encouraged Ukraine to consider striking Moscow to push Putin toward a ceasefire. Though he walked it back publicly, Bryan explains this could be a calculated bluff to pressure the Kremlin as the 50-day ceasefire deadline nears. Syrian Massacre Tests Trump and U.S. Intelligence Syrian troops allied with radical Sunni tribes slaughter over 160 Druze civilians, contradicting assurances that President al-Sharaa was a reformed Islamic leader. Israel launched airstrikes to halt the killings, but Trump asks them to hold off. Bryan questions whether U.S. intel got it wrong—or if al-Sharaa has lost control. Anti-Nausea Drug May Cut Breast Cancer Deaths A Norwegian study finds aprepitant, a common nausea medication, reduces cancer relapse and mortality, especially in aggressive triple-negative cases. Researchers are unsure why, but the drug shows potential as a powerful new ally in chemo treatment. "And you shall know the truth, and the truth shall make you free." – John 8:32

The CyberWire
Chrome's high-risk bug gets squashed.

The CyberWire

Play Episode Listen Later Jul 16, 2025 30:20


Google and Microsoft issue critical updates. CISA warns of active exploitation of a critical flaw in Wing FTP Server. Cloudflare restores their DNS Resolver service following a brief outage. A critical vulnerability in a PHP documentation tool allows attackers to execute code on affected servers. NSA and FBI officials say they've disrupted Chinese cyber campaigns targeting U.S. critical infrastructure. A UK data breach puts Afghan soldiers and their families at risk. Researchers find malware hiding in DNS records. A former U.S. Army soldier pleads guilty to charges of hacking and extortion. Ben Yelin joins us with insights on the Senate Armed Services Committee's response to rising threats to critical infrastructure.The large print giveth and the small print taketh away.  Remember to leave us a 5-star rating and review in your favorite podcast app. Miss an episode? Sign-up for our daily intelligence roundup, Daily Briefing, and you'll never miss a beat. And be sure to follow CyberWire Daily on LinkedIn. CyberWire Guest Today we are joined by Ben Yelin, co host of our Caveat podcast and Program Director for Public Policy & External Affairs at the University of Maryland Center for Cyber Health and Hazard Strategies, discussing the Senate Armed Services Committee's and Trump administration nominees' recent conversation about rising threats to critical infrastructure. You can find the article Ben discusses here. Selected Reading Google fixes actively exploited sandbox escape zero day in Chrome (Bleeping Computer) Windows KB5064489 emergency update fixes Azure VM launch issues (Bleeping Computer) Exploited Wing file transfer bug risks ‘total server compromise,' CISA warns (The Record) Cloudflare 1.1.1.1 incident on July 14, 2025 (Cloudflare) Critical template Injection flaw in LaRecipe Documentation Package enables remote code execution (Beyond Machines) NSA: Volt Typhoon was ‘not successful' at persisting in critical infrastructure (The Record) Defence secretary 'unable to say' if anyone killed after Afghan data breach  (BBC News) Hackers exploit a blind spot by hiding malware inside DNS records (Ars Technica) 21-year-old former US soldier pleads guilty to hacking, extorting telecoms  (The Record) WeTransfer says files not used to train AI after backlash (BBC News) Audience Survey Complete our annual audience survey before August 31. Want to hear your company in the show? You too can reach the most influential leaders and operators in the industry. Here's our media kit. Contact us at cyberwire@n2k.com to request more info. The CyberWire is a production of N2K Networks, your source for strategic workforce intelligence. © N2K Networks, Inc. Learn more about your ad choices. Visit megaphone.fm/adchoices

St. Louis on the Air
STL Baby teeth study from 1960s links radiation and cancers in adults to Coldwater Creek

St. Louis on the Air

Play Episode Listen Later Jul 16, 2025 34:20


On Wednesday a new study by Harvard researchers unveiled new evidence that people who lived near Coldwater Creek as children have a higher than normal risk of developing cancer later in life. Researchers used donated baby teeth from 4,209 participants of the St. Louis Baby Tooth Survey (1958-1970) to assess exposure — and scientists, using the results of self-reported cancer diagnoses, found that incidences of cancer increased in people who lived closer to the creek. The study's lead author, Marc Weisskopf, from the Harvard T.H. Chan School of Public Health, joins Elaine Cha and STLPR health reporter Sarah Fentem to discuss the new findings, and what they tell us about St. Louis' nuclear past, present and future.

J-PAL Voices
Researcher Spotlight: Ariel Zucker on field-driven solutions in development economics

J-PAL Voices

Play Episode Listen Later Jul 16, 2025 15:02


In this episode, host Sambhav Choudhury speaks with Ariel Zucker, Assistant Professor of Economics at UC Santa Cruz. Ariel discusses her journey from an early interest in global health disparities to becoming a development economist specializing in experimental approaches. She shares insights from her research on health interventions for diabetes patients and groundwater conservation in India, highlighting how she balances theoretical frameworks with practical field realities to create meaningful, scalable solutions.

Oncotarget
New Antibody Selectively Targets Immune Cells That Suppress Anti-Tumor Responses

Oncotarget

Play Episode Listen Later Jul 16, 2025 3:49


BUFFALO, NY - July 16, 2025 – A new #research paper was #published in Volume 16 of Oncotarget on July 9, 2025, titled “A novel anti-human CD25 mAb with preferential reactivity to activated T regulatory cells depletes them from the tumor microenvironment.” In this study, researchers from the National Institute of Allergy and Infectious Diseases, led by first author Maja Buszko and corresponding author Ethan M. Shevach, discovered a new monoclonal antibody that selectively targets a subset of immune cells called regulatory T cells (Tregs). These cells, while normally important for preventing autoimmunity, also can block the body's ability to fight cancer by suppressing anti-tumor immune responses. This discovery could lead to novel cancer therapies that strengthen the immune system's capacity to attack tumors. The researchers identified an anti-CD25 monoclonal antibody with several atypical properties and named it 2B010. To evaluate its effects, they used humanized mice, laboratory mice that are engineered to carry human immune cells, to closely mimic how human immune systems respond to cancer. The treatment of these mouse models with 2B010 significantly decreased the number of Tregs in tumors and boosted the activity of CD8+ T cells, which are essential for killing cancer cells. Importantly, 2B010 worked without disrupting other key immune functions. Unlike traditional Anti-CD25 antibodies, it did not interfere with interleukin-2 (IL-2) signaling, which is essential for the growth and activity of effector T cells that fight cancer. “2B010 also had no effect on IL-2 induced STAT5 phosphorylation or CD4+ T cell proliferation in vitro while both were blocked by Clone D1 further supporting the view that 2B010 does not recognize the IL-2 binding site.” This finding is especially significant because high levels of Tregs in tumors are associated with poor outcomes in many cancers. By specifically removing these cells, 2B010 may help overcome one of the main barriers to current immunotherapy approaches. Its ability to preserve IL-2 signaling could also make it safer and more effective when used alone or in combination with existing therapies such as immune checkpoint inhibitors. While the 2B010 antibody showed strong effects in reducing Tregs and boosting immune cell activity, the study did not observe changes in tumor size in these models. Researchers suggest this may be due to limitations in the preclinical systems used, such as the lack of tumor-specific T cells in humanized mice. Nevertheless, these findings demonstrate that 2B010 has a unique mechanism of action that could complement other cancer immunotherapies in future clinical trials. In conclusion, the development of 2B010 is a promising step toward selectively disrupting the immune suppressive environment in tumors. As researchers continue to refine and test this antibody, it could become a powerful tool for enhancing the effectiveness of cancer treatments and improving outcomes for patients. DOI - https://doi.org/10.18632/oncotarget.28752 Correspondence to - Ethan M. Shevach - eshevach@Niaid.NIH.gov Video short - https://www.youtube.com/watch?v=2NJcGsI7WXA Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28752 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, Treg, CD25, TME, mAb, GVHD To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

Outbreak News Interviews
Florida: Conditions exist for indigenous T. cruzi transmission, according to study

Outbreak News Interviews

Play Episode Listen Later Jul 16, 2025 22:16


Chagas disease is caused by the protozoan parasite Trypanosoma cruzi. Nuisance blood-sucking insects known as kissing bugs spread the parasite to humans when exposure to their feces penetrates the mucus membranes, breaches the skin or gets orally ingested. Researchers from the University of Florida Emerging Pathogens Institute and Texas A&M University gathered their resources to investigate the potential of vector-borne transmission of Chagas in Florida.The 10-year-long study, published in the Public Library of Science Neglected Tropical Diseases, used data from Florida-based submissions, as well as field evidence collected from 23 counties across Florida. Joining me today to talk about the study and their findings is Norman Beatty, MD. Dr Beatty is an Assistant Professor of Medicine at the University of Florida College of Medicine. He is also a member of the Emerging Pathogens Institute at the University of Florida.     Field evidence of Trypanosoma cruzi infection, diverse host use and invasion of human dwellings by the Chagas disease vector in Florida, USA

RNZ: Afternoons with Jesse Mulligan
Find out how drone chainsaws could actually improve health and safety

RNZ: Afternoons with Jesse Mulligan

Play Episode Listen Later Jul 16, 2025 11:47


Researchers from the University of Canterbury have successfully developed chainsaw drones with the goal of improving worker safety.

SBS Hindi - SBS हिंदी
Could a weekly injection replace tablets for Parkinson's? Lead researcher Sanjay Garg's study offers hope

SBS Hindi - SBS हिंदी

Play Episode Listen Later Jul 16, 2025 8:40


Researchers at the University of South Australia have developed a long-acting injectable formulation that provides a consistent dose of levodopa and carbidopa—two essential Parkinson's medications—over the course of a week. SBS Hindi spoke with lead researcher Professor Sanjay Garg about how the two-year old study which could represent a breakthrough for those affected by Parkinson's. Parkinson's Australia, the leading advocacy organisation, reports that more than 150,000 Australians are living with Parkinson's disease.

Naked Men Talking
Nahna James - nudist, poet, and researcher

Naked Men Talking

Play Episode Listen Later Jul 16, 2025 14:37


In this episode we're joined by Nahna James.Nahna is a nudist, poet, and researcher exploring body liberation and community, with a focus on naturist culture across the Caribbean, Africa, and Latin America.We talk mirror affirmations, colonialism, and the liberation of connecting with nature.Host: Gareth Johnson (www.gtv.blue)

Dr. Joseph Mercola - Take Control of Your Health
Plastic in Your Lungs Are Ruining Your Immune System - AI Podcast

Dr. Joseph Mercola - Take Control of Your Health

Play Episode Listen Later Jul 15, 2025 8:36


Story at-a-glance Inhaling microplastics disrupts your lung's immune defenses within 24 hours by disabling macrophages, the cells that normally clear out pathogens and waste Once inhaled, plastic particles travel beyond your lungs and accumulate in your liver, brain, kidneys, and colon, raising your risk for inflammation and chronic disease Your body's immune cells cannot break down microplastics and instead hold onto them, causing ongoing immune dysfunction and toxic buildup Researchers are now working to identify early warning signs of microplastic-induced lung damage, including biomarkers that signal rising cancer risk You can lower your daily exposure by filtering your air and water, switching to plastic-free kitchen tools and balancing related hormonal disruption with natural progesterone if needed

Business of Tech
AI Breakthroughs: 92% Health Accuracy, Nonprofit Literacy Tools, and Coding Tool Challenges

Business of Tech

Play Episode Listen Later Jul 15, 2025 18:14


A recent study supported by Apple reveals that a new artificial intelligence model, known as the wearable behavior model, can flag health conditions with an impressive accuracy of 92%. This model, trained on over 2.5 billion hours of data from wearable devices, outperforms traditional health prediction methods that rely solely on basic biometric measurements. Researchers found that behavioral data, such as movement and sleep patterns, often provide stronger health signals than conventional metrics. The model has shown superior performance in dynamic health prediction tasks, including detecting pregnancy and assessing sleep quality.In the realm of education, non-profits are leveraging AI to address global inequities. Education Above All, a non-profit organization based in Qatar, has partnered with prestigious institutions like MIT and Harvard to create DigiWise, a free program aimed at improving AI literacy in developing countries. This initiative allows children to combat misinformation and utilize AI tools in the classroom. Their generative AI chatbot, Furby, is currently being used by over 5 million children in India, providing access to project-based learning resources.However, not all news is positive. A study from the AI benchmarking non-profit, METER, indicates that AI coding tools may actually hinder productivity for experienced developers, increasing task completion time by 19%. Developers had expected these tools to save time, but the reality was a slowdown due to factors such as unrealistic expectations, unfamiliarity with repositories, and the complexity of codebases. This highlights a significant gap between the anticipated benefits of AI tools and their actual performance in real-world scenarios.Additionally, a report from Cloud Zero reveals that while 91% of companies believe their AI investments are yielding returns, only half can substantiate this with concrete data. AI budgets are projected to increase significantly, yet many organizations struggle with visibility into their AI costs and return on investment. This situation underscores the need for effective cost tracking and governance in AI investments, as many companies risk overspending without clear evidence of ROI. The podcast emphasizes the importance of focusing on AI financial governance to help clients navigate these challenges and ensure sustainable growth in the sector. Three things to know today 00:00 Wearable AI Achieves 92% Accuracy While Coding Tools Slow Developers by 19%, Reports Find07:08 Model Wars Heat Up: Open Source Kimi K2 Outperforms GPT-4 While Corporates Cut Chatbot Spend11:53 MSP Workflow Wars: New Integrations Highlight Critical Role of Orchestration in IT Services This is the Business of Tech.    Supported by:  https://cometbackup.com/?utm_source=mspradio&utm_medium=podcast&utm_campaign=sponsorship ThreatDown Webinar:  https://bit.ly/threatdown All our Sponsors: https://businessof.tech/sponsors/ Do you want the show on your podcast app or the written versions of the stories? Subscribe to the Business of Tech: https://www.businessof.tech/subscribe/Looking for a link from the stories? The entire script of the show, with links to articles, are posted in each story on https://www.businessof.tech/ Support the show on Patreon: https://patreon.com/mspradio/ Want to be a guest on Business of Tech: Daily 10-Minute IT Services Insights? Send Dave Sobel a message on PodMatch, here: https://www.podmatch.com/hostdetailpreview/businessoftech Want our stuff? Cool Merch? Wear “Why Do We Care?” - Visit https://mspradio.myspreadshop.com Follow us on:LinkedIn: https://www.linkedin.com/company/28908079/YouTube: https://youtube.com/mspradio/Facebook: https://www.facebook.com/mspradionews/Instagram: https://www.instagram.com/mspradio/TikTok: https://www.tiktok.com/@businessoftechBluesky: https://bsky.app/profile/businessof.tech

Cincinnati Edition
Are UC researchers any closer to finding a functional cure for HIV?

Cincinnati Edition

Play Episode Listen Later Jul 15, 2025 29:16


A UC researcher says they're getting closer — if they can secure funding to continue.

United Public Radio
The Light Gate_ The Mystery of Flight 21 with Experiencer_ Researcher Dave Scott

United Public Radio

Play Episode Listen Later Jul 15, 2025 116:12


Mentorship isn't about hand-holding. It's about alignment, acceleration, and accountability. This isn't theory. This is tactical guidance from someone who's been in the trenches, designed to eliminate confusion, fast-track clarity, and equip you with the tools, mindset, and strategy required to dominate your lane. Whether you're navigating growth, reinvention, or total transformation, this mentorship is where power gets transferred, precision gets sharpened, and results become inevitable. No fluff. No ego. Just real work with real outcomes.

Today from The Ohio Newsroom
Can corncobs help clean Toledo's drinking water?

Today from The Ohio Newsroom

Play Episode Listen Later Jul 15, 2025 4:30


Researchers with the University of Toledo say carbonized corncobs can help clean drinking water contaminated from harmful algal blooms.

The Health Ranger Report
Japanese researchers unleash SMOKING GUN proof of COVID vaccine “death waves” (Brighteon Broadcast News, July 14, 2025)

The Health Ranger Report

Play Episode Listen Later Jul 14, 2025 158:18


- Mike Adams' Broadcast News Introduction and AI Engine Update (0:00) - Discussion on COVID-19 Vaccine Risks and Nature Observations (1:34) - Mushroom Cultivation and Forest Ecosystem Observations (3:38) - Donkey Care and Song Introduction (7:12) - Special Analysis of Vaccine Damage and Deaths (17:50) - Research Findings on Vaccine Deaths and Timing (25:27) - Physiological Processes and Health Recommendations (42:54) - Donations to Texas Flood Victims (59:09) - Technological Advancements and Transhumanism (1:11:24) - Geopolitical Analysis and Financial Implications (1:18:28) - SWIFT System and Geopolitical Implications (1:26:36) - Military Production and Modern Warfare (1:30:40) - Russia's Drone Advancements and NATO's Obsolete Training (1:35:02) - US Military Limitations and Economic Consequences (1:40:14) - Silver and Gold Market Predictions (1:42:06) - Introduction of Guests and Case Background (1:48:18) - Details of Hydrogen Peroxide Treatment (1:54:46) - Legal and Medical Implications (2:05:16) - Challenges in Finding Quality Alternative Care (2:14:17) - Final Thoughts and Call to Action (2:38:11) For more updates, visit: http://www.brighteon.com/channel/hrreport NaturalNews videos would not be possible without you, as always we remain passionately dedicated to our mission of educating people all over the world on the subject of natural healing remedies and personal liberty (food freedom, medical freedom, the freedom of speech, etc.). Together, we're helping create a better world, with more honest food labeling, reduced chemical contamination, the avoidance of toxic heavy metals and vastly increased scientific transparency. ▶️ Every dollar you spend at the Health Ranger Store goes toward helping us achieve important science and content goals for humanity: https://www.healthrangerstore.com/ ▶️ Sign Up For Our Newsletter: https://www.naturalnews.com/Readerregistration.html ▶️ Brighteon: https://www.brighteon.com/channels/hrreport ▶️ Join Our Social Network: https://brighteon.social/@HealthRanger ▶️ Check In Stock Products at: https://PrepWithMike.com

The Changelog
An app can be a home-cooked meal (News)

The Changelog

Play Episode Listen Later Jul 14, 2025 8:45


Researchers in Japan achieve a world record in data transmission speeds, Robin Sloan explains how an app can be a home-cooked meal, Windsurf founders Varun Mohan & Douglas Chen are headed to Google, new Intel CEO Lip-Bu Tan says it's too late for the incumbent, Anton Zaides says stop forcing AI tools on your engineers, and Adrien Friggeri visualized his ten-year running streak.

Voices from The Bench
381: IDS 2025 & exocad Part 6 with Björn Zäuner and Tillmann Steinbrecher

Voices from The Bench

Play Episode Listen Later Jul 14, 2025 60:58


When you think of huge advances in digital dentistry, a lot of companies and names come up. But there are two that are really making a huge impact on how we get things done and they continue to do it with the passion of the lab industry supporting it. First up is Björn Zäuner. Björn grew up in a dental family and wanted nothing to do with teeth. We've all heard this story, right? It wasn't long before Björn had a milling center and even an ortho lab. But he noticed that miss mounted cases were a problem and a main cause to most of his remakes. So he developed Bite-Finder to use AI to find the true bite and not the one "captured" with a blue bite or iOS scanner. He talks all about what it is, how it works, how to integrate it, and how you can try it for FREE for 2 weeks. Then we meet the CEO and co-creator of exocad, Tillmann Steinbrecher. We have talked to literally hundreds of people on this podcast that all sing praises for the "purple program" and this time we get to hear the origin story. Tillmann talks about how is started as a research project where he and his partner saw potential for so much more. From walking around IDS 15 years ago with a laptop with a early version to being one of the leaders in dental design, Tillmann in his team has really changed the way labs stay ahead of the every changing workflow. He talks about the early versions, where the name and purple come from, how it's important to stay an open platform, and the importance of user feedback to keep getting better. Take it from Jennifer Ferguson from Ivoclar. If you have a PM7 (https://www.ivoclar.com/en_us/products/digital-equipment/programill-pm7) or are thinking about getting a PM7 (Take it from Barb, you should), Ivoclar had launched the "Ivoclar Block Module" that can speed up milling emax (https://www.ivoclar.com/en_us/products/digital-processes/ips-e.max-cad) by 45%!! The best part is that you can try it for FREE for 90 days. All you have to do is send them a message on Instagram at Ivoclar.na (https://www.instagram.com/ivoclar.na/) or send a email to jennifer.ferguson@ivoclar.com. Now go mill emax faster! Special Guests: Björn Zäuner and Tillmann Steinbrecher.

Plain English Podcast | Learn English | Practice English with Current Events at the Right Speed for Learners

Today's story: Orcas are the largest type of dolphin, and they're known for their intelligence. A recent study proves they are more clever than previously thought. Researchers captured video of orcas using kelp to groom each other. The behavior shows not only tool use, but also cooperation between individuals—a rare behavior for animals that live in the sea.Transcript & Exercises: https://plainenglish.com/790Full lesson: https://plainenglish.com/790 --Upgrade all your skills in English: Plain English is the best current-events podcast for learning English.You might be learning English to improve your career, enjoy music and movies, connect with family abroad, or even prepare for an international move. Whatever your reason, we'll help you achieve your goals in English.How it works: Listen to a new story every Monday and Thursday. They're all about current events, trending topics, and what's going on in the world. Get exposure to new words and ideas that you otherwise might not have heard in English.The audio moves at a speed that's right for intermediate English learners: just a little slower than full native speed. You'll improve your English listening, learn new words, and have fun thinking in English.--Did you like this episode? You'll love the full Plain English experience. Join today and unlock the fast (native-speed) version of this episode, translations in the transcripts, how-to video lessons, live conversation calls, and more. Tap/click: PlainEnglish.com/joinHere's where else you can find us: Instagram | YouTube | WhatsApp | EmailMentioned in this episode:Ready to improve your listening?Ready to listen fast? Improve your listening with the fast version of this and every episode. The full-speed version is a fresh recording and it sounds just like someone speaking to a native speaker (with no AI or computer manipulation!) You can even listen on a podcast app Sign up for a free 14-day trial at PlainEnglish.com

Climate Connections
A smarter way to tear buildings down

Climate Connections

Play Episode Listen Later Jul 14, 2025 1:31


Researchers are using high-tech tools to identify reusable materials that can be salvaged during building demolitions. Learn more at https://www.yaleclimateconnections.org/ 

Let's Talk AI
#216 - Grok 4, Project Rainier, Kimi K2

Let's Talk AI

Play Episode Listen Later Jul 14, 2025 102:10 Transcription Available


Our 216th episode with a summary and discussion of last week's big AI news! Recorded on 07/11/2025 Hosted by Andrey Kurenkov and Jeremie Harris. Feel free to email us your questions and feedback at contact@lastweekinai.com and/or hello@gladstone.ai Read out our text newsletter and comment on the podcast at https://lastweekin.ai/. In this episode: xAI launches Grok 4 with breakthrough performance across benchmarks, becoming the first true frontier model outside established labs, alongside a $300/month subscription tier Grok's alignment challenges emerge with antisemitic responses, highlighting the difficulty of steering models toward "truth-seeking" without harmful biases Perplexity and OpenAI launch AI-powered browsers to compete with Google Chrome, signaling a major shift in how users interact with AI systems Meta study reveals AI tools actually slow down experienced developers by 20% on complex tasks, contradicting expectations and anecdotal reports of productivity gains Timestamps + Links: (00:00:10) Intro / Banter (00:01:02) News Preview       Tools & Apps (00:01:59) Elon Musk's xAI launches Grok 4 alongside a $300 monthly subscription | TechCrunch (00:15:28) Elon Musk's AI chatbot is suddenly posting antisemitic tropes (00:29:52) Perplexity launches Comet, an AI-powered web browser | TechCrunch (00:32:54) OpenAI is reportedly releasing an AI browser in the coming weeks | TechCrunch (00:33:27) Replit Launches New Feature for its Agent, CEO Calls it ‘Deep Research for Coding' (00:34:40) Cursor launches a web app to manage AI coding agents (00:36:07) Cursor apologizes for unclear pricing changes that upset users | TechCrunch       Applications & Business (00:39:10) Lovable on track to raise $150M at $2B valuation (00:41:11) Amazon built a massive AI supercluster for Anthropic called Project Rainier – here's what we know so far (00:46:35) Elon Musk confirms xAI is buying an overseas power plant and shipping the whole thing to the U.S. to power its new data center — 1 million AI GPUs and up to 2 Gigawatts of power under one roof, equivalent to powering 1.9 million homes (00:48:16) Microsoft's own AI chip delayed six months in major setback — in-house chip now reportedly expected in 2026, but won't hold a candle to Nvidia Blackwell (00:49:54) Ilya Sutskever becomes CEO of Safe Superintelligence after Meta poached Daniel Gross (00:52:46) OpenAI's Stock Compensation Reflect Steep Costs of Talent Wars       Projects & Open Source (00:58:04) Hugging Face Releases SmolLM3: A 3B Long-Context, Multilingual Reasoning Model - MarkTechPost (00:58:33) Kimi K2: Open Agentic Intelligence (00:58:59) Kyutai Releases 2B Parameter Streaming Text-to-Speech TTS with 220ms Latency and 2.5M Hours of Training       Research & Advancements (01:02:14) Does Math Reasoning Improve General LLM Capabilities? Understanding Transferability of LLM Reasoning (01:07:58) Measuring the Impact of Early-2025 AI on Experienced Open-Source Developer Productivity (01:13:03) Mitigating Goal Misgeneralization with Minimax Regret (01:17:01) Correlated Errors in Large Language Models (01:20:31) What skills does SWE-bench Verified evaluate?       Policy & Safety (01:22:53) Evaluating Frontier Models for Stealth and Situational Awareness (01:25:49) When Chain of Thought is Necessary, Language Models Struggle to Evade Monitors (01:30:09) Why Do Some Language Models Fake Alignment While Others Don't? (01:34:35) Positive review only': Researchers hide AI prompts in papers (01:35:40) Google faces EU antitrust complaint over AI Overviews (01:36:41) The transfer of user data by DeepSeek to China is unlawful': Germany calls for Google and Apple to remove the AI app from their stores (01:37:30) Virology Capabilities Test (VCT): A Multimodal Virology Q&A Benchmark

Changelog News
An app can be a home-cooked meal

Changelog News

Play Episode Listen Later Jul 14, 2025 8:45


Researchers in Japan achieve a world record in data transmission speeds, Robin Sloan explains how an app can be a home-cooked meal, Windsurf founders Varun Mohan & Douglas Chen are headed to Google, new Intel CEO Lip-Bu Tan says it's too late for the incumbent, Anton Zaides says stop forcing AI tools on your engineers, and Adrien Friggeri visualized his ten-year running streak.

365 Message Center Show
What's new in the Microsoft 365 Message Center? Ep 386

365 Message Center Show

Play Episode Listen Later Jul 14, 2025 27:59


The Researcher agent is coming to Microsoft Word for M365 Copilot licensed users. This feels like the right place for it to be used, bringing research prompt outputs into a highly capable documentation app.  If you are a subject matter expert and you want to be recognised as one in a Viva Engage community, now you will be able to request to be one.  This and more on this week's episode.  - Researcher is available in Word for Microsoft 365 Copilot licensed users  - Self-nomination as a community expert in Viva Engage communities  - Improved backup and restore experience for Microsoft Authenticator on iOS  - Microsoft 365 Copilot | Viva Engage discussion posts added to grounding sources  - Pin AppBar from Hamburger context menu  - Outlook: Report junk + block or unsubscribe in one same action       Join Daniel Glenn and Darrell as a Service Webster as they cover the latest messages in the Microsoft 365 Message Center.   Check out Darrell & Daniel's own YouTube channels at:  Darrell - https://youtube.com/modernworkmentor  Daniel - https://youtube.com/DanielGlenn   

Oncotarget
Prostate Cancer Cells Survive Treatment by Storing Fat in Low Oxygen Conditions

Oncotarget

Play Episode Listen Later Jul 14, 2025 3:47


BUFFALO, NY – July 14, 2025 – A new #research paper was #published in Volume 16 of Oncotarget on June 25, 2025, titled “Hypoxia induced lipid droplet accumulation promotes resistance to ferroptosis in prostate cancer.” In this study, researchers led by Shailender S. Chauhan and Noel A. Warfel from the University of Arizona discovered that prostate cancer cells survive treatment by storing fats in tiny cellular compartments when oxygen levels are low. This process makes the cancer cells less vulnerable to a type of cell death known as ferroptosis. The findings provide new insight into why prostate tumors often resist therapies and suggest potential strategies to improve treatment outcomes. This study focused on ferroptosis, a form of programmed cell death that relies on iron and lipid oxidation to destroy cancer cells. Researchers tested prostate cancer cells under normal and low oxygen conditions and found that hypoxia, or reduced oxygen levels, allowed cancer cells to build up lipid droplets (LD). These structures act as storage units for fats, shielding cancer cells from oxidative damage and preventing ferroptosis from occurring. The researchers found that this adaptation of prostate cancer cells made them less sensitive to ferroptosis-inducing drugs like Erastin and RSL3, even when these drugs were combined for a stronger effect. The team also reported that hypoxia caused significant changes in lipid metabolism, decreasing the availability of specific fatty acids that normally promote ferroptosis. “Transcriptomic analysis revealed that hypoxia significantly reduced the expression of genes related to incorporating polyunsaturated fatty acids into phospholipids (ACSL4, LPCAT3), and parallel lipidomic analysis demonstrated that hypoxia significantly decreased the levels of the ferroptosis-prone lipid class, phosphatidylethanolamine (PE) and increased production of neutral lipid species, cholesteryl ester (ChE (22:5)) and triglycerides (TG(48:1), TG:(50:4), and TG(58:4)).” This research highlights the importance of the tumor microenvironment, particularly oxygen levels, in shaping how cancer cells respond to therapy. By altering their metabolism and storing lipids, prostate tumors may evade treatments designed to trigger ferroptosis. These findings underscore the need to develop new strategies targeting LD dynamics or lipid metabolism to overcome this resistance. Understanding how prostate cancer (Pca) adapts to survive in hypoxic conditions offers a potential avenue for improving therapies. For example, preventing lipid accumulation in cancer cells or releasing stored fats may restore their sensitivity to ferroptosis and improve the effectiveness of current therapies. This approach could have broader implications for treating other solid tumors that share similar metabolic features. DOI - https://doi.org/10.18632/oncotarget.28750 Correspondence to - Noel A. Warfel - warfelna@arizona.edu, and Shailender S. Chauhan - shailenderc@arizona.edu Video short - https://www.youtube.com/watch?v=xFypDT4ALmc Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28750 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, hypoxia, lipid droplets, ferroptosis, resistance, prostate To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

Changelog Master Feed
An app can be a home-cooked meal (Changelog News #152)

Changelog Master Feed

Play Episode Listen Later Jul 14, 2025 8:45


Researchers in Japan achieve a world record in data transmission speeds, Robin Sloan explains how an app can be a home-cooked meal, Windsurf founders Varun Mohan & Douglas Chen are headed to Google, new Intel CEO Lip-Bu Tan says it's too late for the incumbent, Anton Zaides says stop forcing AI tools on your engineers, and Adrien Friggeri visualized his ten-year running streak.

Science Friday
How These Spiders At The Bottom Of The Sea Eat Methane

Science Friday

Play Episode Listen Later Jul 13, 2025 7:57


Researchers found a new sea spider with a giant nose, leg cannons, and—most remarkably—a novel way of surviving in the lightless, freezing environment miles below the sea surface. These oceanic arthropods are powered by methane that seeps out of the ocean floor.Biologist Shana Goffredi joins Host Flora Lichtman to tell us more about the discovery and explain how we're connected to these little beasts.Guest: Dr. Shana Goffredi is a biology professor at Occidental College in Los Angeles, CA.Transcripts for each episode are available within 1-3 days at sciencefriday.com.  Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

All Things - Unexplained
FBI Raid on Area 51 Website Researcher | TRAILER | All Things Unexplained

All Things - Unexplained

Play Episode Listen Later Jul 13, 2025 2:09


1989: Bob Lazar brought UFO tourism to the quaint town of Rachel, Nevada. 2022: An Area 51 researcher in Rachel was raided by the FBI. NOW, this quaint town is back in the news.

time fbi aliens conspiracies created ufos hearing navy nevada sci fi john f kennedy conspiracy theories researchers bigfoot paranormal mysterious ghost stories raid graves whistleblowers venmo haunted houses disclosure men in black x files abductions roswell stickers comet extraterrestrials area51 close encounters sightings spirit guides paranormal activity top secret meteors unexplained uap density ghost hunters alien abduction ancient aliens space exploration spirit world ghost hunting intergalactic shadow people alien invasion astral projection remote viewing cryptozoology ufo sightings bob lazar psychic abilities ghost adventures spacecraft flying saucers paranormal investigations crop circles alien encounters haunted places caverns avi loeb otherworldly astral travel paranormal podcast extraterrestrial life telekinesis haunted history unidentified flying objects addis ufo crash spirit communication roswell incident secret space programs space aliens superchat paranormal research haunted hospitals ancient astronauts haunted locations unexplained mysteries out of this world alien technology see dr strange creatures close encounters of the third kind unexplained phenomena et contact grusch government secrets supernatural encounters paranormal phenomena interdimensional beings psychic phenomena ufohearing alien races interstellar travel strange lights mounce haunted cemeteries extraterrestrial encounters alien artifacts alien conspiracy interdimensional travel extraterrestrial beings unidentified aerial phenomenon ghost sightings emmit fenn haunted lighthouses ufo documentary supernatural podcast listen follow alien podcast sasquatch encounters nana kwabena space anomalies
Dreamland Podcast – WHITLEY STRIEBER'S UNKNOWN COUNTRY
Are the Visitors Really Coming in 2026-27? Two Prominent Researchers Say Yes. Whitley Weighs In.

Dreamland Podcast – WHITLEY STRIEBER'S UNKNOWN COUNTRY

Play Episode Listen Later Jul 12, 2025 59:48


We’re so used to claims of something big happening in the near future turning out to be wrong that we hardly notice them anymore. But what happens if one turns out to be right? If nonhumans appear suddenly, the consequences will be at least chaotic, and possibly even catastrophic.

Unleash Your Greatness Within
Harvard Researcher Uncovers The Psychology of Exceptional Leadership

Unleash Your Greatness Within

Play Episode Listen Later Jul 11, 2025 56:50


Harvard researcher and author Jeffrey Hull reveals the 9 science-backed ways to expand your leadership impact and influence. This changes everything. I'm thrilled to share this game-changing interview with Jeffrey Hull – Harvard Medical School researcher, executive coach, and author of the upcoming book "The Science of Leadership." In this deep-dive conversation, Jeffrey breaks down the psychology behind exceptional leadership and shares actionable strategies you can implement immediately. What You'll Discover:  • The 9 proven ways to expand your impact and influence as a leader • How conscious leadership transforms your effectiveness • The role of ego in leadership (and how to manage it) • Authentic leadership principles that build trust • Advanced relationship-building strategies • The power of empathy in high-performance teams  • Active listening techniques that create breakthrough moments • Science-backed methods for developing your leadership presence KEY TAKEAWAY: Transform your leadership skills into power skills by applying research-proven strategies from one of Harvard's top leadership experts. ABOUT JEFFREY HULL: Jeffrey Hull is a senior lecturer at Harvard Medical School, executive coach, and author of "The Science of Leadership.” His research focuses on the psychology of exceptional leadership and organizational transformation. CONNECT WITH TJ: Subscribe for more success interviews with world-class experts #Leadership #HarvardResearch #ExecutiveCoaching #PersonalDevelopment #Success #Psychology

Political Gabfest
Who Wants a Third Party, Anyway?

Political Gabfest

Play Episode Listen Later Jul 10, 2025 72:05


This week, David Plotz and guest hosts Mike Pesca and Susan Glasser discuss what to make of Elon Musk's quixotic attempt to start a third political party in America, how Trump's conflation of national interest with self-interest creates an incoherent foreign policy, and the tedious but impactful “summer rerun season” of Trump's tariff folly.  Here are this week's chatters: Mike: ABC7 New York: Traffic deaths across NYC at record low so far this year as City sees historic drop; Tomoki Chein for The San Francisco Standard: Policing has little effect on SF traffic deaths, decades of data show; National Highway Traffic Safety Administration: NHTSA Announces Traffic Fatalities Decreased in the First Quarter of 2025. Susan: Meg Anderson for NPR: Murders are down nationwide. Researchers point to a key reason David: Kyla Scanlon on Substack: Kyla's Newsletter; Clan of the Cave Bear (1980) by Jean M. Auel; Leah Dearborn for LitReactor: What Is ‘The Clan of the Cave Bear,' and Should You Read It? Listener chatter from Alan Spatrick in Newton, Massachusetts: Podcast by Andrew Hickey: A History of Rock Music in 500 Songs For this week's Slate Plus bonus episode, David and guest hosts Mike Pesca and Susan Glasser discuss whether ICE agents should be allowed to do their jobs in masks. In the latest Gabfest Reads, David talks with author Alison Bechdel about her new book, Spent. Email your chatters, questions, and comments to gabfest@slate.com. (Messages may be referenced by name unless the writer stipulates otherwise.) Podcast production by Kevin Bendis Research by Emily Ditto Want more Political Gabfest? Join Slate Plus to unlock weekly bonus episodes. Plus, you'll access ad-free listening across all your favorite Slate podcasts. You can subscribe directly from the Political Gabfest show page on Apple Podcasts and Spotify. Or visit slate.com/gabfestplus to get access wherever you listen. HostsDavid Plotz, Mike Pesca, and Susan Glasser Learn more about your ad choices. Visit megaphone.fm/adchoices

Trumpcast
Political Gabfest | Who Wants a Third Party, Anyway?

Trumpcast

Play Episode Listen Later Jul 10, 2025 72:05


This week, David Plotz and guest hosts Mike Pesca and Susan Glasser discuss what to make of Elon Musk's quixotic attempt to start a third political party in America, how Trump's conflation of national interest with self-interest creates an incoherent foreign policy, and the tedious but impactful “summer rerun season” of Trump's tariff folly.  Here are this week's chatters: Mike: ABC7 New York: Traffic deaths across NYC at record low so far this year as City sees historic drop; Tomoki Chein for The San Francisco Standard: Policing has little effect on SF traffic deaths, decades of data show; National Highway Traffic Safety Administration: NHTSA Announces Traffic Fatalities Decreased in the First Quarter of 2025. Susan: Meg Anderson for NPR: Murders are down nationwide. Researchers point to a key reason David: Kyla Scanlon on Substack: Kyla's Newsletter; Clan of the Cave Bear (1980) by Jean M. Auel; Leah Dearborn for LitReactor: What Is ‘The Clan of the Cave Bear,' and Should You Read It? Listener chatter from Alan Spatrick in Newton, Massachusetts: Podcast by Andrew Hickey: A History of Rock Music in 500 Songs For this week's Slate Plus bonus episode, David and guest hosts Mike Pesca and Susan Glasser discuss whether ICE agents should be allowed to do their jobs in masks. In the latest Gabfest Reads, David talks with author Alison Bechdel about her new book, Spent. Email your chatters, questions, and comments to gabfest@slate.com. (Messages may be referenced by name unless the writer stipulates otherwise.) Podcast production by Kevin Bendis Research by Emily Ditto Want more Political Gabfest? Join Slate Plus to unlock weekly bonus episodes. Plus, you'll access ad-free listening across all your favorite Slate podcasts. You can subscribe directly from the Political Gabfest show page on Apple Podcasts and Spotify. Or visit slate.com/gabfestplus to get access wherever you listen. HostsDavid Plotz, Mike Pesca, and Susan Glasser Learn more about your ad choices. Visit megaphone.fm/adchoices

The Documentary Podcast
Ark of the dry lands

The Documentary Podcast

Play Episode Listen Later Jul 10, 2025 26:29


Researchers in Morocco are developing dry-land agriculture at ICARDA (the International Center for Agricultural Research in the Dry Areas). It is home to a gene bank, in which around 150,000 different seed-types are kept in perfectly calibrated cold vaults, and duplicated to protect them from ‘fire, earthquake and war.' They're used for the creation of new varieties - such as wheat or lentils resistant to drought or disease, without pesticides. The gene bank is a public good - anyone, anywhere, can request seeds free of charge. Laaziza Atmani, head of the Al Amal women's farming co-operative in the middle Atlas Mountains, uses ICARDA seeds and expertise to develop her couscous business. ‘Setting up the co-op changed our lives,' she says.

The CyberWire
Cybercrime has a hefty price tag.

The CyberWire

Play Episode Listen Later Jul 10, 2025 35:48


UK police make multiple arrests in the retail cyberattack case.  French authorities arrest a Russian basketball player at the request of the U.S. A German court declares open season on Meta's tracking pixels. The European Union unveils new rules to regulate artificial intelligence. London's Iran International news confirms cyberattacks from Banished Kitten. Treasury sanctions a North Korean hacker over fake IT worker schemes. Microsoft confirms a widespread issue preventing organizations from deploying the latest Windows updates. Agreements over AI help end a year-long Hollywood strike. Researchers take an  in-depth look at ClickFix. I'm joined by Ben Yelin and Ethan Cook for a look at Congress' recent attempt to limit AI regulation through preemption. Password insecurity with a side of fries. Remember to leave us a 5-star rating and review in your favorite podcast app. Miss an episode? Sign-up for our daily intelligence roundup, Daily Briefing, and you'll never miss a beat. And be sure to follow CyberWire Daily on LinkedIn. CyberWire Guest Today we're sharing our latest Caveat Policy Deep Dive—a special segment where we explore the legal and policy forces shaping our digital lives. In this episode, Ethan Cook joins hosts Dave Bittner and Ben Yelin to break down a recent attempt by Congress to use preemption as a way to block state-level AI laws, and what this means for the ongoing tug-of-war over who should regulate AI in America. For the full conversation and a deeper dive into the implications of this federal vs. state showdown, check out the Caveat podcast Selected Reading UK police arrest four in connection with M&S and Co-op cyberattacks (Reuters) Russian Basketball Player Arrested in France at Request of United States (The Moscow Times) German court rules Meta tracking technology violates European privacy laws (The Record) European Union Unveils Rules for Powerful A.I. Systems (The New York Times) Leaked materials came from previously reported cyberattacks, Iran International confirms (Iran Insight) Treasury sanctions North Korean over IT worker malware scheme (Bleeping Computer) Microsoft confirms Windows Server Update Services (WSUS) sync is broken (Bleeping Computer) Industry video game actors pass agreement with studios for AI security (Reuters) Fix the Click: Preventing the ClickFix Attack Vector (Palo Alto Networks) McDonald's AI Hiring Bot Exposed Millions of Applicants' Data to Hackers Using the Password ‘123456' (WIRED) Audience Survey Complete our annual audience survey before August 31. Want to hear your company in the show? You too can reach the most influential leaders and operators in the industry. Here's our media kit. Contact us at cyberwire@n2k.com to request more info. The CyberWire is a production of N2K Networks, your source for strategic workforce intelligence. © N2K Networks, Inc. Learn more about your ad choices. Visit megaphone.fm/adchoices

Slate Daily Feed
Political Gabfest | Who Wants a Third Party, Anyway?

Slate Daily Feed

Play Episode Listen Later Jul 10, 2025 72:05


This week, David Plotz and guest hosts Mike Pesca and Susan Glasser discuss what to make of Elon Musk's quixotic attempt to start a third political party in America, how Trump's conflation of national interest with self-interest creates an incoherent foreign policy, and the tedious but impactful “summer rerun season” of Trump's tariff folly.  Here are this week's chatters: Mike: ABC7 New York: Traffic deaths across NYC at record low so far this year as City sees historic drop; Tomoki Chein for The San Francisco Standard: Policing has little effect on SF traffic deaths, decades of data show; National Highway Traffic Safety Administration: NHTSA Announces Traffic Fatalities Decreased in the First Quarter of 2025. Susan: Meg Anderson for NPR: Murders are down nationwide. Researchers point to a key reason David: Kyla Scanlon on Substack: Kyla's Newsletter; Clan of the Cave Bear (1980) by Jean M. Auel; Leah Dearborn for LitReactor: What Is ‘The Clan of the Cave Bear,' and Should You Read It? Listener chatter from Alan Spatrick in Newton, Massachusetts: Podcast by Andrew Hickey: A History of Rock Music in 500 Songs For this week's Slate Plus bonus episode, David and guest hosts Mike Pesca and Susan Glasser discuss whether ICE agents should be allowed to do their jobs in masks. In the latest Gabfest Reads, David talks with author Alison Bechdel about her new book, Spent. Email your chatters, questions, and comments to gabfest@slate.com. (Messages may be referenced by name unless the writer stipulates otherwise.) Podcast production by Kevin Bendis Research by Emily Ditto Want more Political Gabfest? Join Slate Plus to unlock weekly bonus episodes. Plus, you'll access ad-free listening across all your favorite Slate podcasts. You can subscribe directly from the Political Gabfest show page on Apple Podcasts and Spotify. Or visit slate.com/gabfestplus to get access wherever you listen. HostsDavid Plotz, Mike Pesca, and Susan Glasser Learn more about your ad choices. Visit megaphone.fm/adchoices