Podcasts about lipids

In this episode, I sit down with Dr. Rupy Aujla, an NHS GP and the founder of The Doctor's Kitchen, an app that includes doctor-approved recipes to cook at home. In this conversation, we dive into why cardiovascular disease remains the #1 killer worldwide, the connection between cholesterol and heart health, how fiber acts as a “magical nutrient” for the body, how to introduce it into your daily meals, and the role of lifestyle choices in preventing illness and supporting long-term brain and heart health. *** About Dr. Rupy Aujla: After suffering a significant heart condition, he dove deep into the science of nutritional medicine and was able to reverse his condition through food and lifestyle. In 2015, he launched The Doctor's Kitchen as a way to teach people how to cook their way to better health and to showcase the medicinal effects of eating well. The incredible “Doctor's Kitchen” cooking app has over 1000 delicious, science-backed recipes and 20 brand new ones added each month. There's also a handy meal planner that will personalise recipes based on your preferences. It actually suggested a delicious looking salmon poached in harissa coconut sauce, and  olive and date braised chicken, which suit my personal dietary needs and all sound great. You can download and use the app completely for free using this link. *** Subscribe to The Neuro Experience for more conversations at the intersection of brain science and performance. I'm committed to bringing you evidence-based insights that you can apply to your own health journey. *** A huge thank you to my sponsors for supporting this episode. Check them out and enjoy exclusive discounts: David's Protein: Buy four cartons and get your fifth one completely free | Head to https://davidprotein.com/pages/neuro Ketone IQ: Go to https://ketone.com/NEURO for 30% OFF your subscription order + receive a free gift with your second shipment. FIGS: You can get 15% off your first order at https://wearfigs.com with the code FIGSRX. Caraway: https://caraway.com/neuro for an additional 10% off your purchase MUDWTR: The coffee alternative. If you're ready to ditch the crash and sip smarter, go to https://mudwtr.com and use code NEURO to get 43% off + free shipping. *** I'm Louisa Nicola — clinical neuroscientist — Alzheimer's prevention specialist — founder of Neuro Athletics. My mission is to translate cutting-edge neuroscience into actionable strategies for cognitive longevity, peak performance, and brain disease prevention. If you're committed to optimizing your brain — reducing Alzheimer's risk — and staying mentally sharp for life, you're in the right place. Stay sharp. Stay informed. Join thousands who subscribe to the Neuro Athletics Newsletter → https://bit.ly/3ewI5P0 Instagram: https://www.instagram.com/louisanicola_/ Twitter : https://twitter.com/louisanicola_ *** Topics: 00:02:43: Lipid panels & overlooked markers 00:05:21: Atherosclerosis explained 00:08:13: Misleading “normal” cholesterol panels 00:10:48: Why heart disease remains #1 killer & prevention timeline 00:12:51: Cholesterol & Alzheimer's; LDL targets for brain health 00:15:12: Cholesterol causality, very low LDL safety 00:19:23: Statins & pharmacological interventions 00:26:02: Ultra-processed foods & saturated fats 00:29:26: Fiber's role in lowering LDL 00:32:05: How fiber binds bile acids & removes cholesterol 00:33:29: Gut microbiome & short-chain fatty acids from fiber 00:35:05: Lowering ApoB, LDL by eating plant-rich foods, portfolio diet 00:37:15: Oats & heart health 00:41:51: Pesticides in fruits and vegetables 00:45:37: Eggs and cholesterol 00:48:18: Soy 00:53:55: Balanced eating 00:57:40: Stress, sleep & cardiovascular disease 00:59:55: Memorable patient stories, family member with stent 01:04:04: How to reduce risk of heart attack or stroke with diet Learn more about your ad choices. Visit megaphone.fm/adchoices

This episode's guests:Kelly Beatty, Sky and Telescope.Kerem Asfuroglu, Dark Source.David Smith, BugLife.Bill's News Picks:Citizen science illuminates the nature of city lights, Nature Cities.  Does darkness increase the risk of certain types of crime? A registered report article, Plos.org.  To Determine if Changing to White Light Street Lamps Reduces Crime: A Multilevel Longitudinal Analysis of Crime Occurrence during the Relighting of Leeds, a UK City, Applied Spatial Analysis and Policy.  Lipid metabolic adaptations during inflammation are controlled by the circadian clock and impaired by light at night, Inflammation Research. Subscribe:Apple PodcastSpotifyYoutubeTag Us and Share with a Friend:InstagramLinkedInTikTokFacebookConnect:Bill@LightPollutionNews.comJoin our Mailing List Send Feedback Text to the Show!Support the showA hearty thank you to all of our paid supporters out there. You make this show possible. For only the cost of one coffee each month you can help us to continue to grow. That's $3 a month. If you like what we're doing, if you think this adds value in any way, why not say thank you by becoming a supporter! Why Support Light Pollution News? Receive quarterly invite to join as live audience member for recordings with special Q&A session post recording with guests. Receive all of the news for that month via a special Supporter monthly mailer. Satisfaction that your support helps further critical discourse on this topic. About Light Pollution News: The path to sustainable starry night solutions begin with being a more informed you. Light Pollution, once thought to be solely detrimental to astronomers, has proven to be an impactful issue across many disciplines of society including ecology, crime, technology, health, and much more! But not all is lost! There are simple solutions that provide for big impacts. Each month, Bill McGeeney, is joined by upwards of three guests to help you grow your awareness and understanding of both the challenges and the road to recovering our disappearing nighttime ecosystem.

Dr. Robert Baron reviews best practices in lipid management for preventing cardiovascular disease, with a focus on statin use. He outlines the strong evidence for statins in reducing heart attack and stroke risk by 25–33%, particularly in patients with clinical atherosclerotic disease, diabetes, or high LDL. He explains why shared decision-making is key in primary prevention, where guidelines vary and risk thresholds are debated. Baron discusses the shift to the newer PREVENT risk calculator, which offers improved accuracy and removes race as a factor. He also explains when additional lipid-lowering medications may be appropriate and clarifies the impact of risk-enhancing factors like family history, coronary artery calcium, and LP(a). [Health and Medicine] [Show ID: 40755]

Dr. Robert Baron reviews best practices in lipid management for preventing cardiovascular disease, with a focus on statin use. He outlines the strong evidence for statins in reducing heart attack and stroke risk by 25–33%, particularly in patients with clinical atherosclerotic disease, diabetes, or high LDL. He explains why shared decision-making is key in primary prevention, where guidelines vary and risk thresholds are debated. Baron discusses the shift to the newer PREVENT risk calculator, which offers improved accuracy and removes race as a factor. He also explains when additional lipid-lowering medications may be appropriate and clarifies the impact of risk-enhancing factors like family history, coronary artery calcium, and LP(a). [Health and Medicine] [Show ID: 40755]

Dr. Robert Baron reviews best practices in lipid management for preventing cardiovascular disease, with a focus on statin use. He outlines the strong evidence for statins in reducing heart attack and stroke risk by 25–33%, particularly in patients with clinical atherosclerotic disease, diabetes, or high LDL. He explains why shared decision-making is key in primary prevention, where guidelines vary and risk thresholds are debated. Baron discusses the shift to the newer PREVENT risk calculator, which offers improved accuracy and removes race as a factor. He also explains when additional lipid-lowering medications may be appropriate and clarifies the impact of risk-enhancing factors like family history, coronary artery calcium, and LP(a). [Health and Medicine] [Show ID: 40755]

Dr. Robert Baron reviews best practices in lipid management for preventing cardiovascular disease, with a focus on statin use. He outlines the strong evidence for statins in reducing heart attack and stroke risk by 25–33%, particularly in patients with clinical atherosclerotic disease, diabetes, or high LDL. He explains why shared decision-making is key in primary prevention, where guidelines vary and risk thresholds are debated. Baron discusses the shift to the newer PREVENT risk calculator, which offers improved accuracy and removes race as a factor. He also explains when additional lipid-lowering medications may be appropriate and clarifies the impact of risk-enhancing factors like family history, coronary artery calcium, and LP(a). [Health and Medicine] [Show ID: 40755]

Dr. Vignesh Devraj explores the Ayurvedic approach to understanding Kapha dosha imbalance through modern biomarkers like cholesterol, insulin resistance, and immune markers. He explains how to differentiate ojas (healthy kapha) from ama (toxic kapha), and the impact of high kapha on issues like weight gain, fatigue, allergies, and depression. You'll also learn powerful lifestyle tips to bring kapha back into balance using diet, exercise, sweating, and Ayurvedic detox therapies like Nasyam and Panchakarma.For a free abstract of this episode, visit vigneshdevraj.comEpisode HighlightsWhat is Kapha? Etymology and core qualitiesLipid profile: Cholesterol, triglycerides, and HDL/LDL explainedOjas vs. Ama: Good vs. bad kaphaAyurveda's concept of immunity (Vyadhi Kshamatva)Lifestyle and Panchakarma Therapies for Kapha BalanceTimestamps00:00 - 02:40: What is Kapha?02:40 - 03:00: Lipid profile and Kapha Imbalance03:00 - 03:30: Ojas vs. Ama: Good vs. bad kapha03:30 - 07:00: Biomarkers, Symptoms and Diseases 07:00 - 08:47: Lifestyle tips, Circadian rhythm & Panchakarma If you are interested in doing one on one Ayurvedic consultation with Dr Vignesh Devraj, please find the details in this link: https://calendly.com/drvignesh/30-minute-session-with-dr-vignesh-devraj-md-ay-istIf you are economically challenged, please use the form provided to request a free Ayurvedic consultation here. (or copy paste this in your browser: https://docs.google.com/forms/d/e/1FAIpQLSd29nHcrC1RssR-6WAqWCWQWKKJo7nGcEm8ITEl2-ErcnfVEg/viewform )You can also visit us at Sitaram Retreat, for bookings check out: www.sitaramretreat.com BALANCE THE MIGHTY VATA - ONLINE COURSE NOW AVAILABLE What makes Ayurveda unique in its treatment approach is its practical wisdom on the concept of Vata. Vata is responsible for Prana - the life energy, nervous system - the master panel of our body, and our emotions. In Ayurveda, it is mentioned that controlling Vata is the most difficult part of healing and recovery. Recently, I have recorded a workshop on - Balancing The Mighty Vata which has over 6 hrs of content, with notes filled with practical inputs that can be integrated into our life. You can access this at https://drvignesh.teachable.com/For further information about Dr Vignesh Devraj, kindly visit www.vigneshdevraj.com and www.sitaramretreat.com Instagram - @sitarambeachretreat | @vigneshdevrajTwitter - @VigneshDevrajWe truly hope you are enjoying our content. Want to help us shape and grow this show faster? Leave your review and subscribe to the podcast, so you'll never miss out on any new episodes. Thanks for your support.Disclaimer: - The content of the podcast episodes is not intended to be a substitute for professional medical procedures, consultations, diagnosis, or treatment in any manner. We strongly do not recommend using the content of these episodes as medical advice for any medical conditions for you, others, or for treating your patients

ReferencesAnal Cell Pathol (Amst).2018; 2018: 787.1814J. Biol. Chem. 2018;293:2422-2437Current Opinion in Structural BiologyVolume 83, December 2023, 102707The Journal of Biological Chemistry 2016.291, 23756-23768Mann, Martinez, O'Neill. 1979 "Angels at My Gate" Manfred Mann EB.https://open.spotify.com/track/2A9wPXzu7uijsOhIpbAH6e?si=2226c50bc7ab4a45Tchaikovsky, PI . 1880. Capricio Italiane" Romeo and Juliet; Nutcracker. https://open.spotify.com/album/0t5AVxOQO5GqqlZW0AeL0c?si=Fwd2uqTtQpqlzhILsRWXQA

A breakthrough in inflammatory support has arrived in the natural health market. PEA, which stands for palmitoylethanolamide, is a naturally occurring fatty acid derivative made in the body and found in small amounts in foods. Several human studies have demonstrated that PEA has broad- spectrum pain-relieving properties, anti-inflammatory effects, and nerve protection.To help us unpack all the research and studies we have Dr. Stengler joining us today.In addition to authoring 30 books on health and several best-sellers such as “The Natural Physician's Healing Therapies,” “Prescription for Natural Cures,” “Prescription for Drug Alternatives,” and “Outside the Box Cancer Therapies,” Dr. Stengler has been published in several peer-reviewed medical journals such as The International Journal of Family & Community Medicine, Endocrinology & Metabolism International Journal, and Journal of Nutritional Health & Food Engineering.Dr. Stengler's, NMD. The newest book is called, The Holistic Guide to Gut Health. A comprehensive yet accessible approach to healing leaky gut and the many uncomfortable symptoms it causes. Dr Stengler is also the founder of The Stengler Center for Integrative Medicine.Talking Points:Palmitoylethanolamide (PEA), is a naturally occurring fatty acid derivative made in the body and found in small amounts in foods. PEA was first discovered in 1957 by scientists at Merck Sharp & Dohme, who isolated it from egg yolk, peanut meal, and soy lecithin. They found that PEA had anti-inflammatory properties in guinea pigs.However, PEA's role as a potential therapeutic agent was not widely recognized until 1993, when Rita Levi-Montalcini and her colleagues published research that suggested PEA has anti-inflammatory properties. Levi-Montalcini's group termed PEA an autocoid local injury antagonist (ALIA), and suggested that it acts locally to counteract injury.Multiple studies have demonstrated that PEA improves all sorts of pain. For example, a 2023 analysis of 11 studies found that PEA improved pain of various conditions, including muscle and joints, nerves, gynecological, and digestive. In terms of joint pain, a high-quality study demonstrated that PEA significantly reduced adult joint pain compared to placebo. Moreover, 8 clinical trials demonstrated that PEA was effective for low back pain, sciatica, and carpal tunnel syndrome. Even migraine headache pain was shown in published research to be improved with PEA.Lipid mediators help to balance the immune, nervous, and endocrine systems, affecting pain pathways related to inflammation. But unfortunately, due to changing diets, many of us do not get the nutrition and activity we need to make enough PEA ourselves.Supplemental PEA, by Levagen+ is properly formulated for optimal bioavailability, 75% more bioavailable to cell receptors than dietary forms. Levagen+ liposomal delivery of PEA has been clinically studied and shows benefits in joint pain, nerve pain, migraine, infections, sleep, and cognitive function.Learn more about Dr. Mark Stengler, NMDLearn more about Emerald Labs PEA+ Levagen Use the code: Forever and get 20% off your order.

In this solo episode of Vegan Boss Radio, I dive into the narratives of ex-vegans who've become outspoken anti-vegans. While I won't name names, I break down some of the common claims they're making, why the science doesn't support them, and how misinformation about plant-based diets continues to spread online. We'll look at: The recurring myths about plant based nutrition Why their symptoms likely weren't caused by a balanced vegan diet How extreme or overly restrictive versions of veganism often lead to burnout I wrap up with an important reminder: if you're unsure whether you're meeting your nutrient needs, or you're dealing with any lingering health issues, it's essential to work with a qualified plant-based health professional. Don't let misinformation derail your progress.

ReferencesActa Pharm Sin B. 2019 Sep 3;10(3):414–433Mechanisms of Ageing and Development2016. Volume 156, Pages 25-33The Journal of Biological Chemistry 2018.293: 2422-2437.Anal Cell Pathol (Amst).2018; 2018: 787.1814.Mozart, WA. 1788. Divertimento 563 in E flat majorhttps://music.youtube.com/playlist?list=OLAK5uy_lDd2hLSAScEFRzcwXGJxrKjTTrPB9uDu0&si=xoAXTM_V9fYzT_cOTaylor and Baker 1968. "Passing the Time. Cream Wheels of Fire lphttps://music.youtube.com/playlist?list=OLAK5uy_lDd2hLSAScEFRzcwXGJxrKjTTrPB9uDu0&si=xoAXTM_V9fYzT_cOMeade, N. . 1964. "Time is On My Side." Rolling Stoneshttps://music.youtube.com/watch?v=7jStGLgQkSw&si=ufgxy8kPLG6djqWNCroce, J. 1974. "Time in a Bottle"https://music.youtube.com/watch?v=9h1davKgBYM&si=LEy6JDkroVjcT-lU

ReferencesCellular Signaling 2018 .Volume 46, June :129-134Free Radic Biol Med. 2021 Jul; 170: 59–69. J Vis Exp. 2020 Oct 27:(164)Acta Pharmaceutica Sinica B 2023. Volume 13, Issue 10, October :4089-4104Bruford/Squire/Anderson. 1972. "Heart of the Sunrise" Live Yessongs.https://music.youtube.com/watch?v=Ar_ObQIssRM&si=fE6vosqHz-DA9O17Lennon/McCartney. 1968. "Hello Goodbye" Magical Mystery Tour. Beatleshttps://music.youtube.com/watch?v=ywZqBGHDTlA&si=bBc_qmYfM_VFaVFn

ReferencesFront Immunol. 2017 Jun 9;8:643Acta Pharm Sin B. 2019 Sep 3;10(3):414–433Zappa, F. 1968 "Flower Punk" Mother's of Invention .We are only in it for the Money lp https://music.youtube.com/watch?v=HQfZmMI87P4&si=UyDyEQtzmAivWcMeZappa, F. 1976. "Black Napkins" on Zoot allures lp.https://music.youtube.com/watch?v=RfHT-T6R6WY&si=79BxfAu-YWlrg9wcCouperin, F. 1716. Pieces d' Clavecin. Livre 2. Order 6. les Bergerieshttps://music.youtube.com/watch?v=wOQRIoXptPo&si=D9SawR9a-cMB2qYt

ReferencesFront Immunol. 2017 Jun 9;8:643JAMA. 2021;325(16):1640-1649Journal of Hepatology 2012 56, 704-713DOI:(10.1016/j.Annual Review of Food Science and Technology.2022.  Volume 13:263-286Annual Review of Pathological Mechanisms of Disease 2010. 5:99-118.Nature.2013 Jul 4;499(7456):97-101 Nature Reviews Gastroenterology and Hepatology 26 April 2019Cell Metabolism 2019. [29] 4:886-900Lamm, R. 1972. "While the City Sleeps" Chicago Vhttps://music.youtube.com/watch?v=qCrgrGsBlr0&si=oGMvJDfCrd2BU7_ICetera and Seraphine . "Lowdown" Chicago IIIhttps://music.youtube.com/watch?v=6LlZCBbeZTk&si=DrSyAp9lCzhZyqfWLamm, R. 1969. "Questions 67 and 68" CTAhttps://music.youtube.com/watch?v=0TKaFqhmmg4&si=_W-MMatKBBQ0cBF9

ReferencesThe Journal of Nutritional Biochemistry 2016.Volume 34, pages 1-7Immunologic Research,2020. 1559-0755,Feb, Vol. 68, Issue 1Cell Metabolism 2019. [29] 4:886-900Guerra, DJ.2025. Unpublished LecturesAnderson and Howe. 1971. "Roundabout" Yes.https://music.youtube.com/watch?v=pk3HBb0mh5Q&si=dO7xDgnAVqNl8Yv6Davis, T. 1971 "Your Saving Grace" Steve Miller Bandhttps://music.youtube.com/watch?v=RBJ6teB2IXw&si=etBGUDK87GprtnlrLennon/McCartney 1967. "She's Leaving Home" Beatles SPLHCB.https://music.youtube.com/watch?v=VaBPY78D88g&si=9upPJq5KC_jBDQI0Lennon/McCartney. 1966. "She Said" Revolver, lp Beatleshttps://music.youtube.com/watch?v=rLzfo59AdEc&si=r-AiTLLNsphoME0y

REFERENCESFront Immunol.2019; 10: 1064.ASN Neuro. 2024 Nov 5;16(1):2404367.Int J Mol Sci. 2024 Apr 10;25(8):4199Page/Jones/Plant 1969. "Since I've Been Loving You" LZ III lp.https://open.spotify.com/track/1SDiiE3v2z89VxC3aVRKHQ?si=530d2dcc304f4199Lennon/McCartney, 1964. "I Don't Want to Spoil the Party"https://open.spotify.com/track/3kQDIa85ZK8cKVn72NfBnl?si=be68c3abca6341d8Lennon/McCartney 1967. "A Day in the Life" Sgt Pepper's LHCB. lp.https://open.spotify.com/track/0hKRSZhUGEhKU6aNSPBACZ?si=8589b727398f4fbbBiber, H.I.F. 1676. "Passacaglia in G Minor. Violin sonatahttps://open.spotify.com/track/2PvqhaYNHP4zHQynKeook4?si=479490bfb34c4c2d

ReferencesMol Cancer Ther. 2018 Jan; 17(1): 50–59 J Neuroinflammation. 2019; 16: 236. Cell Host Microbe. 2016 Feb 10; 19(2): 181–193Nat Rev Microbiol. 2009 Feb; 7(2): 99–109.Cells.2020 Feb 5;9(2).Biochimica et Biophysica Acta (BBA) - Biomembranes. 2016.Volume 1858, Issue 11, November Pages 2681-2688Nat Immunol. 2024 Apr 8;25(5):778–789. Dylan, B. 1975. "Tangled up in Blue"https://music.youtube.com/playlist?list=OLAK5uy_nHWCTvQI-G4uNRNvC0AjQr9hVXG54TeSU&si=xOVhlpdBm_ygXirlMcQuinn 1971. "Pale Blue" Byrdmaniax l phttps://youtu.be/Mh3J7GqrdzY?si=UtahiK75LoZhQLe7Baker, G. 1967. "Blue Condition" Cream Disraeli Gears lp.https://youtu.be/bOAkjNX1FDI?si=3q_FcsfvWTH95RyK

In this episode, Dr. Erin Mulvihill discusses the advancements in metabolism research that broadens our understanding of the mechanisms behind diabetes and heart health. Through models of both diseases, it is hypothesized that similar hormones and lipids can act as drug targets to improve patient outcomes.Learn more: https://www.ottawaheart.ca/profile/mulvihill-erin-e

ReferencesCell Metabolism 2024. volume 36, Issue 4, 2 April : 839-856.e8Winwood/Davis. 1966 "Giimme Some Lovin" Spencer Davis Group.https://music.youtube.com/watch?v=BuQ3PaFyb9A&si=yAERzThIMPra_Ct1Cochran and Capehart. 1958. "Summertime Blues" The Who Live at Leeds lp.https://music.youtube.com/watch?v=ovHs-psC9F4&si=zLwITLtjW0aCwKPAVivaldi, A 1717-1718. "Summer" Violin Concerto. Marie Samuelson. No. 2 in G minor, Op. 8, RV 315,https://music.youtube.com/watch?v=g65oWFMSoK0&si=jw6PDRYCagn-B4fC

ReferencesFront. Immunol., 22 February 2024. Sec. Multiple Sclerosis and Neuroimmunology Volume 15 Nat Cell Biol. 2019 Mar; 21(3): 397–407.CELL 2006. Volume 126, Issue 3, 11 August Pages 503-514Valenti, D. 1971. "Dont Cry My Lady Love"https://music.youtube.com/watch?v=Aqt0yhGfC1s&si=fXpd1HifSgtEHtpbLennon/McCartney. 1966. "For No One"Revolver. lp.https://music.youtube.com/watch?v=ELlLIwhvknk&si=ZgDZXKn_UPC3RHBmMozart, WA. 1773. Symphony 25 in G Minorhttps://music.youtube.com/watch?v=707oHEGF6l8&si=rwJRSJ2CeYfYVIas

Ying Tam, Chief Scientific Officer at Acuitas Therapeutics, discusses the company's role in delivering the first personalized CRISPR gene editing treatment to an infant with CPS-1, achieving treatment in just six months from diagnosis. Tam shares insights on evolving lipid nanoparticle technology beyond COVID vaccines, including LNPs that allow for next-generation immune-targeting delivery that is 10x more potent, and progress in delivering genetic medicines to stem cells and solid tumors. He also addresses the challenges of repeat dosing, a new biodegradable LNP formulation, and expanding genetic medicine beyond the liver to treat blood disorders and cancer.

A new study published recently as the cover of Aging Volume 17, Issue 6, describes a new method to estimate how fast the brain is aging. By analyzing lipids, or fat molecules, in brain tissue, researchers from the National University of Singapore and Hanze University of Applied Sciences created a biological “clock” called DoliClock. This innovation highlights how conditions such as autism, schizophrenia, and Down syndrome are associated with accelerated brain aging. Understanding Brain Aging As people grow older, their brains naturally change. However, in many neurological disorders, these changes seem to appear earlier and progress more rapidly. Disorders like autism, schizophrenia, and Down syndrome reduce quality of life and contribute to premature death. Scientists have long searched for better ways to measure biological age in the brain to understand these processes and develop strategies to slow them down. Most existing methods for estimating biological age rely on genetic markers, such as DNA methylation, which are chemical modifications of DNA. While useful, these approaches may not fully capture the complexity of aging, especially in the brain. Lipids, which are essential components of brain cells and play important roles in energy storage and signaling, offer another perspective. Full blog - https://aging-us.org/2025/07/doliclock-a-lipid-based-clock-for-measuring-brain-aging/ Paper DOI - https://doi.org/10.18632/aging.206266 Corresponding author - Brian K. Kennedy - bkennedy@nus.edu.sg Video short - https://www.youtube.com/watch?v=-FEiyj9PjBE Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206266 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, aging clock, down syndrome, autism, schizophrenia, dolichol To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

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Host: Perry Elliott Guest: Karim Lekadir Want to watch that episode? Go to: https://esc365.escardio.org/event/1808?r Disclaimer: ESC TV Today is supported by Bristol Myers Squibb and Novartis. This scientific content and opinions expressed in the programme have not been influenced in any way by its sponsors. This programme is intended for health care professionals only and is to be used for educational purposes. The European Society of Cardiology (ESC) does not aim to promote medicinal products nor devices. Any views or opinions expressed are the presenters' own and do not reflect the views of the ESC. The ESC is not liable for any translated content of this video. The English-language always prevails. Declarations of interests: Stephan Achenbach, Nicolle Kraenkel and Karim Lekadir have declared to have no potential conflicts of interest to report. Carlos Aguiar has declared to have potential conflicts of interest to report: personal fees for consultancy and/or speaker fees from Abbott, AbbVie, Alnylam, Amgen, AstraZeneca, Bayer, BiAL, Boehringer-Ingelheim, Daiichi-Sankyo, Ferrer, Gilead, GSK, Lilly, Novartis, Pfizer, Sanofi, Servier, Takeda, Tecnimede. Davide Capodanno has declared to have potential conflicts of interest to report: Bristol Myers Squibb, Daiichi Sankyo, Sanofi Aventis, Novo Nordisk, Terumo. Perry Elliott has declared to have potential conflicts of interest to report: consultancies for Pfizer, BMS, Cytokinetics, AstraZeneca, Forbion. Steffen Petersen has declared to have potential conflicts of interest to report: consultancy for Circle Cardiovascular Imaging Inc. Calgary, Alberta, Canada. Emma Svennberg has declared to have potential conflicts of interest to report: Abbott, Astra Zeneca, Bayer, Bristol-Myers, Squibb-Pfizer, Johnson & Johnson."

This episode covers: Cardiology This Week: A concise summary of recent studies Big data in cardiology Measuring lipids: what clinicians need to know Milestones Host: Perry Elliott Guests: Carlos Aguiar, Karim Lekadir, Kostas Koskinas Want to watch that episode? Go to: https://esc365.escardio.org/event/1808 Disclaimer: ESC TV Today is supported by Bristol Myers Squibb and Novartis. This scientific content and opinions expressed in the programme have not been influenced in any way by its sponsors.  This programme is intended for health care professionals only and is to be used for educational purposes. The European Society of Cardiology (ESC) does not aim to promote medicinal products nor devices. Any views or opinions expressed are the presenters' own and do not reflect the views of the ESC. The ESC is not liable for any translated content of this video. The English-language always prevails. Declarations of interests: Stephan Achenbach, Nicolle Kraenkel and Karim Lekadir have declared to have no potential conflicts of interest to report. Carlos Aguiar has declared to have potential conflicts of interest to report: personal fees for consultancy and/or speaker fees from Abbott, AbbVie, Alnylam, Amgen, AstraZeneca, Bayer, BiAL, Boehringer-Ingelheim, Daiichi-Sankyo, Ferrer, Gilead, GSK, Lilly, Novartis, Pfizer, Sanofi, Servier, Takeda, Tecnimede. Davide Capodanno has declared to have potential conflicts of interest to report: Bristol Myers Squibb, Daiichi Sankyo, Sanofi Aventis, Novo Nordisk, Terumo. Perry Elliott has declared to have potential conflicts of interest to report: consultancies for Pfizer, BMS, Cytokinetics, AstraZeneca, Forbion. Kostas Koskinas has declared to have potential conflicts of interest to report: speaker fees / honoraria from MSD, Daiichi-Sankyo. Steffen Petersen has declared to have potential conflicts of interest to report: consultancy for Circle Cardiovascular Imaging Inc. Calgary, Alberta, Canada. Emma Svennberg has declared to have potential conflicts of interest to report: Abbott, Astra Zeneca, Bayer, Bristol-Myers, Squibb-Pfizer, Johnson & Johnson.

BUFFALO, NY — July 1, 2025 — A new #research paper, featured on the #cover of Aging (Aging-US) Volume 17, Issue 6, was #published on June 4, 2025, titled “DoliClock: a lipid-based aging clock reveals accelerated aging in neurological disorders.” This study, led by first author Djakim Latumalea from the National University of Singapore and Hanze University of Applied Sciences, with corresponding author Brian K. Kennedy from the National University of Singapore, introduces DoliClock, a biological aging clock based on lipid profiles in the human brain. The researchers found that individuals with autism, schizophrenia, and Down syndrome show signs of accelerated brain aging compared to individuals without these conditions. The discovery offers a new approach to measuring brain aging using lipid markers instead of traditional DNA-based methods. The team developed DoliClock using lipidomic data from post-mortem prefrontal cortex samples. Lipids are fat-like molecules that play a key role in brain health. Changes in lipid patterns can reflect the biological age of brain tissue. The study focused on a specific class of lipids called dolichols, which increase gradually with age. The DoliClock model was trained to predict biological age by analyzing levels of dolichols and other lipid molecules. It accurately estimated brain age and revealed higher aging rates in individuals with neurological disorders. One notable finding was a sharp increase in lipid profile variability—also known as entropy—around the age of 40. This suggests a disruption in lipid metabolism during midlife, possibly caused by changes in the mevalonate pathway, a critical biological process involved in producing lipids like cholesterol and dolichol. These disruptions may contribute to aging-related brain decline. The study also found that dolichol levels could serve as reliable biomarkers of aging. Their consistent increase with age and strong influence on DoliClock's predictions make them especially useful. In individuals with autism, schizophrenia, and Down syndrome, the clock indicated more advanced biological brain aging than expected, supporting the idea that these conditions are associated with premature aging. DoliClock offers a new perspective in aging research, complementing existing biological clocks based on DNA or protein markers. Because it relies on lipids, it may detect aspects of aging that other tools cannot. While the current model is based on brain tissue samples, future research may examine whether similar lipid patterns can be identified in more accessible fluids such as blood or cerebrospinal fluid. “These findings suggest that lipidomics can provide valuable insights into the molecular mechanisms of brain aging and neurological disorders.” This study highlights the growing potential of lipidomics in the study of aging and neurological disorders. It opens the door to new biomarkers that could help researchers and clinicians better monitor brain aging and develop more targeted interventions for age-related and neurodevelopmental diseases. DOI - https://doi.org/10.18632/aging.206266 Corresponding author - Brian K. Kennedy - bkennedy@nus.edu.sg Video short - https://www.youtube.com/watch?v=-FEiyj9PjBE Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Saturated fat is one of the most controversial topics in nutrition and one of the most misunderstood. In this episode of the Chasing Clarity Podcast, I'm joined by Alan Flanagan and Danny Lennon of Sigma Nutrition Radio to break down what the science actually says about saturated fat, LDL cholesterol and heart disease.PART 1: WHAT SATURATED FAT DOES TO BLOOD LIPIDS⁃ WHY METABOLIC WARD STUDIES ARE THE GOLD STANDARD FOR ISOLATING SATURATED FAT'S EFFECTS⁃ SUBSTITUTION ANALYSES — WHAT HAPPENS WHEN SATURATED FAT IS REPLACED WITH UNSATURATED FAT⁃ THE KEYS EQUATION & IMPORTANCE OF THE P:S RATIOPART 2: SATURATED FAT & HEART DISEASE RISK⁃ WHAT THE SEVEN COUNTRIES STUDY ACTUALLY FOUND & HOW IT'S BEEN MISREPRESENTED⁃ RCT EVIDENCE LINKING SFA REDUCTION TO LOWER CHD RISK⁃ PUBLIC HEALTH OUTCOMES: THE FINNISH DIET-HEART SUCCESS STORY⁃ THRESHOLDS FOR SATURATED FAT INTAKEPART 3: PRACTICAL APPLICATION⁃ MOST EFFECTIVE DIETARY STRATEGIES FOR IMPROVING LIPIDS⁃ SIMPLE FOOD SWAPS TO REDUCE SFA & INCREASE UNSATURATED FATS⁃ MOST COMMON MYTHS DEBUNKEDWHERE TO CONNECT WITH ME:Follow Brandon on IG: https://www.instagram.com/brandondacruz_/Email: Bdacruzfitness@gmail.comFor Info on Brandon's Coaching Services: https://form.jotform.com/bdacruzfitness/coachinginquiryBrandon's Website: https://www.brandondacruzfit.com

In this illuminating episode of Better Buildings for Humans, host Joe Menchefski welcomes physicist and daylighting pioneer Marilyne Andersen for a conversation that sheds new light—literally—on how architecture affects our health, productivity, and sense of well-being. From the science of chronobiology to eye morphology and colored glazing, Marilyne explains how light exposure shapes everything from our mood to our sleep cycles. She shares insights from her groundbreaking research at EPFL and her work with the Daylight Academy, revealing why daylight may be more than a design feature—it might be a human right. Plus, discover how her new role at GESDA is helping bridge the gap between scientific discovery and societal impact. A must-listen for anyone designing spaces for real human needs.More About Marilyne Andersen:Marilyne Andersen is a Full Professor at EPFL and head of the LIPID lab since 2010, after 6 years at MIT as tenure-track professor. Since April 2025, she is also the Director General of the GESDA foundation (Geneva Science and Diplomacy Anticipator), whose mission is to anticipate emerging scientific discoveries and translate them into concrete actions for the benefit of society by engaging proactively with policymakers and diplomats. Physicist by training, she specializes in the psycho-physiological effects of (day)light with broader research interests on sustainability in the built environment. She has been Dean of ENAC at EPFL (2013-2018), Academic Director of the Smart Living Lab until 2024 and member of the Board of the Holcim Foundation for Sustainable Construction (2015-2024). She was also Visiting Professor at the Lawrence Berkeley Lab in California and at SUTD in Singapore. Author of over 250 refereed papers with several distinctions, she was the global Daylight Research Award's inaugural laureate in 2016 and led the winning Swiss team for the Solar Decathlon 2017 competition. At EPFL, she is currently Head of the SKIL for project-based learning and PI of the Swiss-wide SWICE consortium on the energy transition. She is also co-founder of the consulting startup OCULIGHT dynamics.In parallel, she has been actively engaged in bridging the gap between art and science, notably since 2021 as co-curator of the exhibition entitled Lighten Up! On Biology and Time and as author of the Circa Diem immersive installation and policy-oriented fiction Droit au Jour ; these works have been on display in diverse venues such as the Seoul Biennale, the EPFL Pavilions, the Gewerbemuseum Winterthur, the Museum of Contemporary Design and Applied Arts (mudac) in Lausanne, and will be showcased at the MIT Museum in 2025-2026.CONTACT:https://www.linkedin.com/in/marilyne-andersen-b617aa1/https://people.epfl.ch/marilyne.andersen Where To Find Us:https://bbfhpod.advancedglazings.com/www.advancedglazings.comhttps://www.linkedin.com/company/better-buildings-for-humans-podcastwww.linkedin.com/in/advanced-glazings-ltd-848b4625https://twitter.com/bbfhpodhttps://twitter.com/Solera_Daylighthttps://www.instagram.com/bbfhpod/https://www.instagram.com/advancedglazingsltdhttps://www.facebook.com/AdvancedGlazingsltd

ReferencesFood Nutr Res. 2017 Aug 13;61(1):1361779.J Neuroinflammation. 2019; 16: 34Biochimica et Biophysica Acta (BBA) - Molecular and CellBiology of Lipids 2015.Volume 1851, Issue 1, January 51-60Circ Res. 2012 Aug 31;111(6):800–814Front Immunol. 2019; 10: 345.Jagger/Richards, et al 1964. 12X5 full album. Rolling Stoneshttps://music.youtube.com/playlist?list=OLAK5uy_mY9_HvpUSqlIZC_wgCRNoLX2ECLQzak08&si=HZXf4khOf0dNrvbBLennon/ McCartney and Harrison 1964. Beatles Second Albumhttps://music.youtube.com/watch?v=ayw_IqMMYfg&si=4dB76zNDvEzdu2o5Mozart, WA. 1773 & 1775. Complete I-V Violin Concertihttps://music.youtube.com/watch?v=Rmhtc-VWLek&si=M9R5w2-9-hPq5-f8

This episode covers:  Cardiology this Week: A concise summary of recent studies Coronary sinus reducer: promise in refractory angina Best strategies to reach LDL cholesterol goals in high-risk patients Snapshots Host: Susanna Price Guests: Carlos Aguiar, Rasha Al-Lamee, J. Wouter Jukema, Steffen Petersen Want to watch that episode? Go to: https://esc365.escardio.org/event/1807 Want to watch that extended interview on LDL management? Go to: https://esc365.escardio.org/event/1807?resource=interview Disclaimer ESC TV Today is supported by Bristol Myers Squibb and Novartis. This scientific content and opinions expressed in the programme have not been influenced in any way by its sponsors. This programme is intended for health care professionals only and is to be used for educational purposes. The European Society of Cardiology (ESC) does not aim to promote medicinal products nor devices. Any views or opinions expressed are the presenters' own and do not reflect the views of the ESC. Declarations of interests Stephan Achenbach, Nicolle Kraenkel and Susanna Price have declared to have no potential conflicts of interest to report. Rasha Al-Lamee has declared to have potential conflicts of interest to report: speaker's fees for Menarini pharmaceuticals, Abbott, Philips, Medtronic, Servier, Shockwave, Elixir. Advisory board: Janssen Pharmaceuticals, Abbott, Philips, Shockwave, CathWorks, Elixir. Carlos Aguiar has declared to have potential conflicts of interest to report: personal fees for consultancy and/or speaker fees from Abbott, AbbVie, Alnylam, Amgen, AstraZeneca, Bayer, BiAL, Boehringer-Ingelheim, Daiichi-Sankyo, Ferrer, Gilead, GSK, Lilly, Novartis, Pfizer, Sanofi, Servier, Takeda, Tecnimede. Davide Capodanno has declared to have potential conflicts of interest to report: Bristol Myers Squibb, Daiichi Sankyo, Sanofi Aventis, Novo Nordisk, Terumo. J. Wouter Jukema has declared to have potential conflicts of interest to report: J. Wouter Jukema/his department has received research grants from and/or was speaker (CME accredited) meetings sponsored/supported by Abbott, Amarin, Amgen, Athera, Biotronik, Boston Scientific, Dalcor, Daiichi Sankyo, Edwards Lifesciences, GE Healthcare Johnson and Johnson, Lilly, Medtronic, Merck-Schering-Plough, Novartis, Novo Nordisk, Pfizer, Roche, Sanofi Aventis, Shockwave Medical, the Netherlands Heart Foundation, CardioVascular Research the Netherlands (CVON), the Netherlands Heart Institute and the European Community Framework KP7 Programme. Steffen Petersen has declared to have potential conflicts of interest to report: consultancy for Circle Cardiovascular Imaging Inc. Calgary, Alberta, Canada. Emma Svennberg has declared to have potential conflicts of interest to report: Abbott, Astra Zeneca, Bayer, Bristol-Myers, Squibb-Pfizer, Johnson & Johnson.

Host: Susanna Price Guest: J. Wouter Jukema Want to watch that extended interview on LDL management? Go to: https://esc365.escardio.org/event/1807?resource=interview Want to watch the full episode? Go to: https://esc365.escardio.org/event/1807 Disclaimer ESC TV Today is supported by Bristol Myers Squibb and Novartis. This scientific content and opinions expressed in the programme have not been influenced in any way by its sponsors. This programme is intended for health care professionals only and is to be used for educational purposes. The European Society of Cardiology (ESC) does not aim to promote medicinal products nor devices. Any views or opinions expressed are the presenters' own and do not reflect the views of the ESC. Declarations of interests Stephan Achenbach, Nicolle Kraenkel and Susanna Price have declared to have no potential conflicts of interest to report. Carlos Aguiar has declared to have potential conflicts of interest to report: personal fees for consultancy and/or speaker fees from Abbott, AbbVie, Alnylam, Amgen, AstraZeneca, Bayer, BiAL, Boehringer-Ingelheim, Daiichi-Sankyo, Ferrer, Gilead, GSK, Lilly, Novartis, Pfizer, Sanofi, Servier, Takeda, Tecnimede. Davide Capodanno has declared to have potential conflicts of interest to report: Bristol Myers Squibb, Daiichi Sankyo, Sanofi Aventis, Novo Nordisk, Terumo. J. Wouter Jukema has declared to have potential conflicts of interest to report: J. Wouter Jukema/his department has received research grants from and/or was speaker (CME accredited) meetings sponsored/supported by Abbott, Amarin, Amgen, Athera, Biotronik, Boston Scientific, Dalcor, Daiichi Sankyo, Edwards Lifesciences, GE Healthcare Johnson and Johnson, Lilly, Medtronic, Merck-Schering-Plough, Novartis, Novo Nordisk, Pfizer, Roche, Sanofi Aventis,Shockwave Medical, the Netherlands Heart Foundation, CardioVascular Research the Netherlands (CVON), the Netherlands Heart Institute and the European Community Framework KP7 Programme. Steffen Petersen has declared to have potential conflicts of interest to report: consultancy for Circle Cardiovascular Imaging Inc. Calgary, Alberta, Canada. Emma Svennberg has declared to have potential conflicts of interest to report: Abbott, Astra Zeneca, Bayer, Bristol-Myers, Squibb-Pfizer, Johnson & Johnson.

JACC's June 10 guideline issue features a series of viewpoints on the ACS guidelines. In this video, author Kausik Ray, MD, FACC, discusses the 2025 ACC/AHA Acute Coronary Syndrome guidelines, focusing on lipid management. He highlights the shift from solely using statins to incorporating combination therapies, emphasizing the importance of simultaneous initiation of combination therapies with statins, ezetimibe, and PCSK9i early in specific high-risk groups rather than a sequential strategy. This could help align implementation of clinical practice more closely with available evidence and help narrow the well-established implementation gaps in the real-world care.

Do you find lipids fascinating? Exciting? Full of whimsy? My guest today does and after listening to this episode, I think you will, too (at least a little bit)!Josh Wageman is a prior physical therapist turned physician associate. He works as a Clinical Lipid Specialist and formerly practiced in Endocrinology prior to transitioning to a Medical Science Liaison. His PhD work focused on cholesterol disturbances in Alzheimer's Disease. Josh translated his PhD studies and clinical work into his book, The Home Security System and the Lipid Neighborhood: Un-Complicating Cholesterol and Cardiovascular Disease. Josh's goal is to help people not have heart attacks, strokes, and dementia by explaining complicated biochemical concepts in a relatable way. He's even been known to write rap songs and pop parodies about lipids. Tune in to learn the top things you can start TODAY to prevent heart attacks, strokes, and dementia. You might even laugh along the way.BUY JOSH'S BOOK: The Home Security System and the Lipid Neighborhood: Un-Complicating Cholesterol and Cardiovascular DiseaseSPONSORS

JACC focuses in again on Lipids in our June 3 issue, bringing critical insights into emerging targeted therapies. In the June 3 Deep Dive, editor-in-chief Harlan M. Krumholz, MD, SM, FACC, reviews the INTERASPIRE study by Ray et al, reviewing implications, key findings, and a thoughtful summary and analysis of the reviewer findings.

Send us a textDr. Adrian Soto-Mota is a returning guest on our show! Be sure to check out episode 138 of Boundles Body Radio, which was part of a special series we did, featuring Dr. Nick Norwitz as the guest host!We also hosted Dr. Soto-Mota on episode 340, episode 419, and episode 599 of our show!Dr. Soto-Mota is a MD PhD & Specialist in Internal Medicine and Data Science researcher at the Unidad de Investigación de Emfermedades Metabólicas! Dr. Soto-Mota is passionate about studying low carbohydrate and ketogenic diets, and how they impact human metabolism.Dr. Soto-Mota earned his MD from the Universidad Nacional Autónoma de México, and earned his Ph.D. at Oxford. He has created many resources to help people successfully implement a low carbohydrate diet, and provides that help for both English and Spanish speaking individuals.He is the co-author of a 2022 paper titled The Lipid Energy Model: Reimagining Lipoprotein Function in the Context of Carbohydrate-Restricted Diets, and the co-author of the recent paper titled Plaque Begets Plaque, ApoB Does Not: Longitudinal Data From the KETO-CTA Trial- JACC Journal April 7, 2025, both of which were also co-authored by former guests Dr. Norwitz and Dave Feldman, who we hosted in episode 109 of Boundless Body Radio!Find Dr. Soto-Mota at-TW- @AdrianSotoMotaPlaque Begets Plaque, ApoB Does Not: Longitudinal Data From the KETO-CTA Trial- JACC Journal April 7, 2025Keto Cholesterol study SHOCKS scientific community | LMHRs & heart disease from the Nutrition Made Simple YouTube ChannelAnalyzing the KETO-CTA Study with Dr. Gil Carvalho 813 on Boundless Body Radio!Discussing Keto-CTA with Darius Sharpe with Dave Feldman and Darius SharpeFind Boundless Body at- myboundlessbody.com Book a session with us here!

Are you really wanting to improve your heart health, but feel lost on what to do? All you know is that you've been warned by your doctor to ‘change your diet'. But which one and how? There seem to be so many different ones out there, that it's confusing and overwhelming. So can a vegan diet or a plant-based one really help drop blood lipids, lower your risk of a heart attack and give you more time with loved ones?   Let's find out on today's podcast. In this episode, we'll see how effective a vegan or whole food plant-based diet can be and I'll also share the experience of some from my Community. So if you're ready to build better heart health naturally, meet me inside this episode!   Related Episodes: Ep. 90 | Her Cholesterol & Triglycerides Drop Within 3 Weeks & Husband's Diabetes Improves – Interview with Susan [Part 1]: https://www.plantnourished.com/blog/interview-with-susan-part-one   Ep. 91 | Weight Loss and Tips for Staying Plant-Based With a Busy Life - Interview With Susan [Part 2]: https://www.plantnourished.com/blog/91-interview-with-susan-part-two]     Contact -> healthnow@plantnourished.com Learn -> www.plantnourished.com Join -> Plant-Powered Life Transformation Course: www.plantnourished.com/ppltcourse Connect in the Facebook Community -> www.bit.ly/pbdietsuccess Apply -> Free Rapid Health Transformation Call: https://bit.ly/plantnourished Free Resource -> Quick Start Grocery Guide for Plant-Based Essentials: www.plantnourished.com/groceryguide     Have a question about plant-based diets that you would like answered on the Plant Based Eating Made Easy Podcast? Send it by email (healthnow@plantnourished.com) or submit it by a voice message here: www.speakpipe.com/plantnourished     [Plantbased Diet, Plant Based Eating, Cholesterol, Triglycerides, Heart Health, Cardiovascular Health, Heart Attacks, Strokes, How to Eat for Health]

To help us unpack all the research and studies we have Dr. Stengler joining us today.In addition to authoring 30 books on health and several best-sellers such as “The Natural Physician's Healing Therapies,” “Prescription for Natural Cures,” “Prescription for Drug Alternatives,” and “Outside the Box Cancer Therapies,” Dr. Stengler has been published in several peer-reviewed medical journals such as The International Journal of Family & Community Medicine, Endocrinology & Metabolism International Journal, and Journal of Nutritional Health & Food Engineering.Dr. Stengler's, NMD. The newest book is called, The Holistic Guide to Gut Health. A comprehensive yet accessible approach to healing leaky gut and the many uncomfortable symptoms it causes. Dr Stengler is also the founder of The Stengler Center for Integrative Medicine.Talking Points:Palmitoylethanolamide (PEA), is a naturally occurring fatty acid derivative made in the body and found in small amounts in foods. Several human studies have demonstrated that PEA has broad-spectrum pain-relieving properties, anti-inflammatory effects, and nerve protection.PEA was first discovered in 1957 by scientists at Merck Sharp & Dohme, who isolated it from egg yolk, peanut meal, and soy lecithin. They found that PEA had anti-inflammatory properties in guinea pigs.However, PEA's role as a potential therapeutic agent was not widely recognized until 1993, when Rita Levi-Montalcini and her colleagues published research that suggested PEA has anti-inflammatory properties. Levi-Montalcini's group termed PEA an autocoid local injury antagonist (ALIA), and suggested that it acts locally to counteract injuryMultiple studies have demonstrated that PEA improves all sorts of pain. For example, a 2023 analysis of 11 studies found that PEA improved pain of various conditions, including muscle and joints, nerves, gynecological, and digestive. In terms of joint pain, a high-quality study demonstrated that PEA significantly reduced adult joint pain compared to placebo. Moreover, 8 clinical trials demonstrated that PEA was effective for low back pain, sciatica, and carpal tunnel syndrome. Even migraine headache pain was shown in published research to be improved with PEA.Lipid mediators help to balance the immune, nervous, and endocrine systems, affecting pain pathways related to inflammation. But unfortunately, due to changing diets, many of us do not get the nutrition and activity we need to make enough PEA ourselves.Supplemental PEA, by Levagen+ is properly formulated for optimal bioavailability, 75% more bioavailable to cell receptors than dietary forms. Levagen+ liposomal delivery of PEA has been clinically studied and shows benefits in joint pain, nerve pain, migraine, infections, sleep, and cognitive function.Learn more about Emerald Labs PEA+ Levagen Use the code: Forever and get 20% off your order. 

Welcome to my podcast. I am Doctor Warrick Bishop, and I want to help you to live as well as possible for as long as possible. I'm a practising cardiologist, best-selling author, keynote speaker, and the creator of The Healthy Heart Network. I have over 20 years as a specialist cardiologist and a private practice of over 10,000 patients. In this podcast, Dr. Warrick Bishop, a cardiologist and CEO of the Healthy Heart Network, discusses the significance of genetics in cholesterol-related health issues. He explains the difference between monogenic and polygenic influences on lipid profiles, with monogenic abnormalities being linked to single genetic mutations that significantly impact cholesterol levels, such as familial hypercholesterolemia. In contrast, polygenic issues involve multiple small genetic variations that collectively affect cholesterol without causing as severe elevations.

Welcome to The Superhumanize Podcast.I'm your host, Ariane Sommer and today, we're not just talking about heart health…We're decoding it.My guest is Dr. Ronald Krauss, one of the most influential voices in cardiovascular research today. A professor of medicine at UCSF and a pioneer in lipidology, Dr. Krauss has reshaped how we understand cholesterol, inflammation, and the subtle particles that move through our blood and, often, determine our fate.In this conversation, we go far beyond the standard cholesterol panel.We explore the deeper nuances like the size and density of LDL particles, the overlooked power of ApoB and Lp(a), and how refined carbohydrates, not saturated fats, may play a much larger role in cardiovascular risk than we've been led to believe.We also enter emerging frontiers:How the gut microbiome shapes the heart, how our genes can guide more precise therapies, and how personalized nutrition may become one of the most powerful tools for prevention in the years to come.This episode is not just for the curious, it's for those who sense there's more to the story of heart disease than numbers on a lab report.It's for those who believe science can be both evidence-based and visionary.And for those of us who know the body carries not just risk, but memory, intelligence, and code.Episode highlights:Why small, dense LDL particles are more dangerous than large onesThe role of ApoB and Lp(a) as underused but powerful heart health indicatorsHow metabolic syndrome and inflammation interconnect with lipid disordersThe surprising truth about saturated fat vs. refined carbsThe promise (and limitations) of personalized nutrition and genomicsHow physical activity and gut health shape lipid metabolismNew frontiers in the fight against dementia linked to cardiovascular functionResources mentioned:Dr. Krauss' Wikipedia page:https://en.wikipedia.org/wiki/Ronald_Krauss_(medical_researcher)Dr. Krauss' professional profiles:https://profiles.ucsf.edu/ronald.krausshttps://amecenter.ucsf.edu/people/ronald-krauss-md

In this episode, we're talking all things grassfed whey—a supplement we recommend to nearly every client for good reason. From weight loss and lean body mass to metabolic and immune health, the benefits of whey are powerful and broad spectrum. We break down what whey protein is, how it's made, and why we choose to use a whey concentrate over an isolate. We dive into the synergistic compounds found only in whey concentrates that are low heat processed like lactoferrin, CLA, and immunoglobulins—and how they go beyond muscle to support immune resilience, gut lining integrity, and even antioxidant production via glutathione synthesis. We're thrilled to unveil Whey Protect—our upgraded version of Naturally Nourished Grassfed Whey, now with added serum bovine immunoglobulins to further support immunity and reduce inflammation. We touch on how our formula stacks up in purity compared to mainstream brands and discuss the Clean Label Project's recent findings on heavy metals in popular protein powders. Plus, we share our favorite ways to incorporate Whey Protect into your daily routine for optimal health! Also in this episode:  Whey Protect Now Available - use code NN Whey for 15% off!  Episode 288: Whey Protein: lactoferrin, immunoglobulins, BCAAs and more!  Episode 368 What's up with Armra Colostrum? Serum Bovine Immunoglobulins vs. Colostrum What is whey and how is it made?  Comparing whey concentrate to whey isolate Compounds that make whey a superfood Immunoglobulins (IgG, IgA, IgM) – Immune Defense & Gut Health Lactoferrin – Iron-Binding Protein with Antimicrobial Power Glycomacropeptides (GMPs) – Gut & Brain Health Serum Albumin – Antioxidant & Detox Support Growth Factors (IGF-1, TGF-β) – Muscle Growth & Tissue Repair Why are are adding Serum Bovine Immunoglobulins to Whey Protect Gut Health & Leaky Gut Repair Immune System Resilience Detoxification & Inflammation Control Recovery from exercise induced stress Whey and muscle protein synthesis, workout recovery & fat loss Whey Protein Supplementation Enhances Whole Body Protein Metabolism and Performance Recovery after Resistance Exercise: A Double-Blind Crossover Study The Effect of Whey Protein Supplementation on the Temporal Recovery of Muscle Function Following Resistance Training: A Systematic Review and Meta-Analysis Inulin-type fructans and whey protein both modulate appetite but only fructans alter gut microbiota in adults with overweight/obesity: A randomized controlled trial - PubMed Cocoa and Whey Protein Differentially Affect Markers of Lipid and Glucose Metabolism and Satiety Effects of whey protein and resistance exercise on body composition: a meta-analysis of randomized controlled trials  Whey and antioxidant production Whey Protein Supplementation Improves Nutritional Status, Glutathione Levels, and Immune Function in Cancer Patients: A Randomized, Double-Blind Controlled Trial Concerns with heavy metal toxicity & why you don't need to worry about this with Whey Protect!  Lead and cadmium found in muscle-building protein powders, report says | CNN 2024-25 Protein Powder Category Report How to use Whey Protect Banana Bolt Smoothie Matcha Green Smoothie Cinnamon Almond Keto Shake Cherry Vanilla Nirvana Smoothie How to Make a Keto Protein Shake and The Importance of Protein Easy Keto Green Smoothie (with super foods!) What makes Whey Protect Superior? Grass-fed, low-heat whey concentrate → Preserves bioactive compounds Contains ImmunoLin® serum bovine immunoglobulins → Supports immunity & gut health Rich in cysteine & glutathione → Powerful antioxidant support Boosts muscle growth & recovery → High leucine for optimal muscle synthesis Clean, third-party tested → No heavy metals or contaminants Sponsors for this episode:  Whey Protect: introducing our new Grassfed Whey with added serum bovine immunoglobulins to meet your protein goals and protect the body against infection, toxins, and regulate inflammatory response!   We saw the demands with sales increase of our GI Immune Builder and wanted to incorporate the therapeutic benefits of immunoglobulins in a daily easy to use product that can be used for enhanced immune function, metabolic results, and gut health.   Our Grassfed Whey has always been a top selling product in the Naturally Nourished line due to our quality sourcing and low heat processing to retain antioxidants and beneficial immune compounds such as lactoferrin and immunoglobulins. We wanted to ensure when you take our whey that you are providing your body with a shield of defense against pathogens (bacteria, virus, parasites, mold), toxins, and oxidative stress. Meet Whey Protect, our reformulated and enhanced Naturally Nourished Grassfed Whey.   We've added 350mg serum bovine immunoglobulins to each scoop to ensure you and your family receive a clinical impact to Protect you while helping you reach your daily protein goals with ease.    You're just a scoop a-WHEY from: Muscle gains  Immune resilience Improved bone density Gut health Lower toxicity Enhanced antioxidant status Reduced inflammation Weight loss with satiety and appetite regulation   Added Value at no added cost! We are thrilled to offer you this amazing upgrade at the same price, plus save during our launch sale! Use the code NNWHEY for 15% off    This episode is sponsored by Wild Foods, a company that puts quality, sustainability, and health first in all of their products. They have everything from coffee to turmeric to medicinal mushrooms, and every single product is painstakingly sourced from small farms around the globe. They take their mission seriously to fix the broken food system, and believe real food is medicine. They've partnered with us to give you guys an exclusive discount, so use the code ALIMILLERRD for 12% off your order at WildFoods.co! 

In this episode, we're going deep on Carbon 60—also known as C60 or buckyballs. If you've ever wondered how a molecule that started life as an industrial lubricant ended up a star player in the world of anti-aging, you're in for a treat. Ian and I talk about the original studies that blew everyone's minds (including a rat study where the animals lived nearly twice as long as expected!), and we discuss Ian's own hands-on research, from mouse models to dogs, horses, and even human applications.   What we discuss: C60 explained: origins, “buckyballs,” and research ... 00:08 C60 rat and mouse longevity studies ... 00:09 Lipid binding & targeted delivery ... 00:16 C60: antioxidant, adaptogen, mitochondrial effects ... 00:18 Athlete case study & performance benefits ... 00:25 Applications for fatigue, brain fog, metabolic issues ... 00:32 Autoimmune/inflammatory benefits & mitochondrial origins ... 00:34 Hair, scalp, and ovarian health ... 00:38 Neurodegeneration, glymphatics & brain serums ... 00:45 Optimizing cognition & cycling C60 ... 00:51 Safety notes: who should avoid and why ... 00:53 Product lineup & new developments ... 01:01 What to look for in C60 products ... 01:09   Our Amazing Sponsors: LVLUP - Neuro Re-Generate the world's first liposomal triple peptide formula, designed to support mental clarity, focus, and overall brain health. Visit www.lvluphealth.com and use code NAT10 for 10% off your order.   Peptide Pro App - When you're working with multiple peptides, timing and precision matter. From smart scheduling to real-time dose checklists, it keeps things organized and on track. Receive 50% off for the first month. Visit www.peptidepro.app to download the app and use code NATHALIE50 to get started today.   Wizard Sciences (Neural Rx) - designed to protect your brain long-term. With C60 (an antioxidant) and anti-inflammatory benefits, it combats oxidative stress and helps keep those brain cells healthy and happy. Plus, it supports mitochondrial efficiency, meaning more energy and focus for the long haul. Use code NAT15 at checkout to get 15% off your purchase. Visit wizardsciences.com.    Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

In this conversation with Dr. Heather Sandison, we explore what I consider to be one of medicine's most significant misunderstandings—that Alzheimer's disease, particularly in women, is an unstoppable fate. We examine the evidence behind cognitive decline, hormones, lifestyle interventions, and a framework for preventing and even reversing what was once considered irreversible.If you're interested in making evidence-based decisions about your brain health, understanding why traditional approaches have failed, or learning about the powerful role of lifestyle interventions in cognitive function, this episode provides both the scientific rationale and actionable strategies you need.Subscribe to The Neuroscience Experience for more conversations that challenge conventional thinking about brain health. I'm committed to bringing you insights that transform how we approach cognitive aging and performance. SponsorsA huge thank you to my sponsors for supporting this episode. Check them out and enjoy exclusive discounts:Hone Health – Take control of your hormones with at-home testing designed specifically for men. Get personalized insights and expert guidance to optimize your health and performance. Learn more at: https://honehealth.com/Momentous – Science-backed supplements trusted by elite athletes and experts. Whether you're looking to improve recovery, performance, or overall wellness, Momentous has you covered. Use code NEURO for 20% off your order: https://www.livemomentous.com/neuroTroscriptions – Unlock your cognitive potential with precision-dosed nootropics developed by medical experts. Whether you need more focus, clarity, or energy, Troscriptions offers innovative solutions.- Get 10% off: https://troscriptions.com/NEURO- https://troscriptions.com/discount/NEUROMAIL?utm_source=affiliate&utm_medium=email&utm_campaign=NeuroMail Episode Timestamps:  00:00 Why Are Women More Vulnerable to Alzheimer's? 06:13 The Role of Hormone Replacement Therapy 11:24 Understanding Alzheimer's Disease and Dementia 17:04 Alzheimer's Drugs vs. Lifestyle Interventions That Work 29:50 APOE Gene, Genetic Risk, Lipids, and Cholesterol in Alzheimer's 37:47 How the Ketogenic Diet Impacts Brain Health 41:11 GLP-1 Agonists and Their Role in Cognitive Health 44:30 How Infections Contribute to Cognitive Decline 48:00 Plasma Exchange and Alternative Therapies 52:09 Foundational Health Practices & Dual Task Exercise 54:17 Conclusion and Further Resources The Neuro Athletics Newsletter Instagram: @louisanicola_Twitter : @louisanicola_YouTube: @Louisa NicolaThe Neuro Experience Podcast is proud to have hosted: Dr Andrew Huberman, Dr Gabrielle Lyon, Dr Layne Norton, Thomas DeLauer, Shawn Stevenson, Dr. Rocio Salas-Whalen, Saad Alam, Uma Naidoo, Dr. Lanna Cheuck, Angela Lee Pucci, Jillian Turecki, Dr. Jordan Feigenbaum, Dr. Darren Candow, Dr. Sue Varma, Evy Poumpouras, Dr Casey Means, Renee Deehan, Dr Chris Palmer, Dr Charles Brenner, Dr Joe Zundell, Dr Ray Dorsy, Dr Dale Bredeson, Dr. Ben Bikman

Send us a textShort Summary: Cancer's metabolic roots with Dr. Thomas Seyfried.About the guest: Thomas Seyfried, PhD is a professor of biology at Boston College. He has researched cancer metabolism, epilepsy, and lipid biochemistry for over 40 years.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Transcript and other information on Substack.Episode Summary: Dr. Thomas Seyfried discusses the mitochondrial metabolic theory of cancer, challenging the dominant somatic mutation theory. He explores how cancer cells rely on fermentation due to defective oxidative phosphorylation, drawing on Otto Warburg's work. Seyfried explains how ketogenic diets and nutritional ketosis can starve cancer cells by limiting glucose and glutamine, while sharing evidence from nuclear transfer experiments and clinical studies. The conversation also covers environmental factors driving cancer and the importance of metabolic flexibility for prevention.Key Takeaways:Cancer is characterized by dysregulated cell growth, but Seyfried argues it stems from mitochondrial dysfunction, not just genetic mutations.Cancer cells ferment glucose & glutamine, unable to use fatty acids or ketones, making ketogenic diets a potential therapeutic tool.Nuclear transfer experiments show cancer traits reside in the cytoplasm, not the nucleus, challenging the somatic mutation theory.Environmental factors like processed foods, stress, and poor sleep disrupt mitochondrial function, increasing cancer risk.Seyfried's glucose-ketone index helps monitor metabolic states to manage cancer & chronic diseases.Cancer rates are rising in younger people, possibly due to obesity, inflammation, and environmental toxins.Metabolic flexibility, cycling between ketosis and carb-based states, may mimic ancestral patterns and reduce chronic disease risk.Related episode:M&M #215: Cancer Metabolism: Sugar, Fructose, Lipids & Fasting | Gary PattiSupport the showAll episodes, show notes, transcripts, etc. at the M&M Substack Affiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Readwise: Organize and share what you read. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. For all the ways you can support my efforts

This is a segment from one of our Premium-exclusive AMA (ask me anything) episodes, where we answer questions submitted by Premium subscribers. To listen to the full episode, you'll need to be a Premium subscriber and access the episode on the private Premium feed. Questions Answered in This Episode [02:00] Why does the Mediterranean diet emphasize monounsaturated fats over polyunsaturated fats when the latter seem more beneficial for heart health? [08:48] What dietary patterns or foods best support strength and recovery in premenopausal women, especially on a plant-based diet? [20:33] Are there specific foods or supplements that help regenerate or protect connective tissue in conditions like EDS? [28:39] What does the current evidence say about the keto diet during cancer treatment, and are there specific cancers where it might be beneficial? [43:31] What are the biochemical processes behind fat loss, including fat mobilization, transport, and any potential short-term cardiovascular risks? [59:48] What is the most effective system for organizing, structuring, and retrieving accumulated knowledge over time? [1:10:37] Do you agree with Dr. Tom Dayspring that a significant percentage of people are hyper-absorbers of dietary cholesterol, making food cholesterol impactful for them? [1:14:35] Is consuming 2g of protein per pound of body weight safe if calorie intake is high and well-balanced? Links Subscribe to Sigma Nutrition Premium Go to sigmanutrition.com

In today's episode of Barbell Shrugged you will learn: What are lipids What is cholesterol The difference between HDL and LDL cholesterol Why there is no such thing as “good” or “bad” cholesterol What are the bloodwork numbers for optimal cholesterol What is the perfect ratio of HDL and LDL Ratios for Triglycerides to HDL for optimal health Mechanisms for regulating cholesterol in the liver Why saturated fats are not bad and how your body uses them Cholesterols role in testosterone production To learn more, please go to https://rapidhealthoptimization.com Connect with our guests: Anders Varner on Instagram Doug Larson on Instagram Coach Travis Mash on Instagram Dan Garner on Instagram

Savanna and Tyler are joined by Eduardo Perez, the genius Chief Science Officer behind Epicutis Skincare! From the roots of chia seeds and collagen-saving magic to groundbreaking studies on TSC and retinoids, they're spilling the sciencey tea. They dive deep into why Lipid Serum is basically liquid ibuprofen for your face, the truth about skincare innovation, and what's next for Epicutis (spoiler: new launch incoming