Podcasts about hdl ldl

Ben and Dave are back with a deep dive into their latest supplement stacks, why they've changed, what bloodwork revealed, and what's actually working right now.

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Reviewing conversations about cholesterol.

❤️ Bonjour,Bienvenue dans ce nouvel épisode d'"En plein cœur", où l'on continue notre saga sur le cholestérol ! Aujourd'hui, je vous explique pourquoi ce n'est pas tant le cholestérol le problème, mais plutôt la manière dont il circule dans votre corps.

What's up all you Vipers! Welcome to this weeks show and thanks for all of the love shared after our 250th episode! Mr and Mrs Weedman get normal toking on Sour Secrets from their award winning friends, @Midwest_Terpzz_ and then get right to business, delivering the latest hot topics, research, reports and news from the all around the world. In this episode, Mr Weedman shares a piece focusing on the benefits of terpenes while fighting flu viruses, ways to use weed to soothe a sore throat, and the potential for weed to lower your cholesterol.  Mrs Weedman shares a study finding that CBD and CBG can help treat ezcema, insight on CBD infused pillow cases for better rest, perspective on the potential to decrease anxiety with citrus based d-limonene, and more. Thanks for listening and as always, hit us up!TWITTER: @weedman420podYouTube: Weedman420 ChroniclesEMAIL:  weedman420chronicles@gmail.comSHOP: www.eightdecades.comIG: @eightdecadesEMAIL: eightdecadesinfo@gmail.comSign up for our Newsletter @ www.eightdecades.com #ImHigh #Cannabis #StomptheStigma #HomeGrow #FreethePlant #Stoners #Burners #rosin #liverosin #Potheads #Vipers #CannabisEducation #CannabisResearch #Weed #Marijuana #LegalizeIt #CannabisNews #CBD #Terpenes  #Podcast #CannabisPodcast #eightdecades #LPP #Lifestyle #HealthyLifestyle #NaturalMedicine #PlantMedicine #News #Research #MedicalMarijuana #Infused #420 #Education #Health #Wellness #WorldNews #Gardening #budtender #kief #hemp #dabs #hash #joints #edibles #gummies #tincture #vapes #esters #pauliesayssmokesmart #lastprisonerproject Article Links:* https://internationalhighlife.com/new-study-suggests-terpenes-and-cbd-may-help-block-covid-19-and-flu-viruses/* https://www.marijuanamoment.net/an-ointment-with-the-marijuana-components-cbd-and-cbg-can-effectively-treat-symptoms-of-eczema-study-shows/* https://www.marijuanamoment.net/using-cbd-infused-pillowcases-leads-to-improved-sleep-quality-for-nurses-new-study-finds/?utm_source=flipboard&utm_content=Cpizzo721/magazine/Marijuana+Investing* https://thefreshtoast.com/cannabis/can-marijuana-help-cholesterol/* https://www.earth.com/news/cannabis-related-anxiety-may-be-reduced-with-citrus-based-oil-d-limonene/* https://mjbizdaily.com/cannabis-consumers-seek-more-than-thc-potency/?utm_source=flipboard&utm_content=otherCOPYRIGHT 2021 WeedMan420Chronicles©Suggestions? Questions? Chat with us here.

The doctor looks you in the eye and says, "You have high cholesterol." Now what? Statins are not the answer! Not by a long shot! Dr. Tom Cowan of the New Biology Clinic reminds us that there is no correlation between high cholesterol and heart attacks, heart disease, or early death. He sheds light on the HDL/LDL ratio questions and suggests that cholesterol tests, in the first place, do not provide helpful data in any case.   Find out what Tom recommends instead to maintain a healthy heart and a healthy lifestyle. Visit his website: drtomcowan.com   Subscribe to this podcast on your favorite podcast app   Check out our sponsors: Earth Runners and Paleo Valley   Visit his website: drtomcowan.com

Wellness + Wisdom Episode 625 Wellness + Wisdom Podcast Host and Wellness Force Media CEO, Josh Trent, shares his experience and advice about how to deal with the stress that accompanies challenging times in our lives, his #1 tip on how to get back to homeostasis and heal disease, and what men can do every day to practice self-love. Send Josh your AMA Question HERE! Today's Questions Stacie: I'm a beach volleyball coach, and I help kids through some first big life transitions, trying to get committed to playing college volleyball. What advice would you give them to manage stepping into something uncomfortable and unknown and what practices would help them navigate the stresses of it? Hayley: When it comes to holistic health and really getting to the root cause of a person's health and well-being, what system in the body, mind, and spirit are you looking to first? Is it the digestive system? Is it the nervous system? Is it our energetic chakras? From your perspective and from all knowledge and wisdom, what is the first line of defense that you are looking to support and to nourish when we're looking at deep holistic health? Faraz Khan: I am going through a practice of self-love and understanding the parts of me that I haven't loved in my childhood and going back to those. And so I'm super curious of what you do, how do you show up every single day with love and grace and compassion for yourself? And when the daily stressors hit you and your nervous system gets dysregulated, how do you bring that back into balance? And how do you hold love for yourself and for your kids and for your family? So I'm super curious about any tips, techniques, or practices that you use just for more self-love, brother. Love you. ❄️ Biohack Your Mind & Body with Plunge Ice Baths! Save $150 on your PLUNGE order with code "WELLNESSFORCE" As seen on Shark Tank, Plunge's revolutionary Cold Plunge uses powerful cooling, filtration, and sanitation to give you cold, clean water whenever you want it, making it far superior to an ice bath or chest freezer. ☀️ Live Life Well from Sunrise to Sunset Save 20% with code "WELLNESSFORCE" on everyone's favorite Superfoods brand, ORGANIFI, including their Sunrise to Sunset Bundle and their Women's Power Stack that includes HARMONY + GLOW for true hormonal balance and great health radiating through your beautiful skin. Click HERE to order your Organifi today.

In this episode of the Iron Sights podcast, Stephen, Cece, and I challenge the notion that lowering LDL cholesterol is the primary key to preventing heart disease. Amidst the ongoing debates on diets—carnivore, keto, low carb, and plant-based—we get into interesting studies like ones involving Oreos, revealing surprising insights about cholesterol. We break down the basics, discussing what cholesterol does in the body, the effects of drugs, and more.Timestamps00:00 Intro03:10 Topic: Blood Test And Cholesterol06:19 Do Oreos Cookies Lower Your Cholesterol?10:01 How Your Body Deals With Cholesterol13:42 The Number One Killer In The US15:48 What Does Your Body Need Cholesterol For?17:24 Triglycerides19:56 Statin Medications25:26 The Lipid Energy Theory37:06 The Side Effects Of Statins48:32 Increasing Fiber In Your Diet To Reduce Your LDL Levels58:38 Why Is It Important To Take Full Blood Panels?Red Dot Fitness Training Programs:https://www.rdftrainonline.comOnline Membership (Full Access To All Programs & Virtual Coaching):https://www.reddotfitness.net/online-membershipVirtual Coaching:https://www.reddotfitness.net/virtual-coachingSelf-Guided Programs:https://www.reddotfitness.net/Self-Guided-Programs1Connect With Us:Website - https://ironsightspodcast.com/Instagram - https://www.instagram.com/ironsightspodcast/Facebook - https://www.facebook.com/ironsightspodcast/

Michelle Hurn, RD unravels the science, debunks myths, and provides you with practical insights into how your diet can be a powerful ally in your mental health journey. Michelle shares how she went from feeling trapped by depression and anxiety to finding a sense of hope and vitality after making simple dietary changes. Support your Workout Sessions and Healthy Hydration with the Electrolyte + Creatine Combo by MYOXCIENCE: https://bit.ly/electrolyte-stix  *Save 12% with code podcast at checkout Link to expanded show notes: https://bit.ly/3tPRxXG Michelle's Book: https://amzn.to/3tBUhrC Show Notes: 0:00 Intro 01:30 Michelle was a carb fueled athlete.  06:50 Vitamins and cofactors from meat are crucial for your brain.  12:00 Processed foods are designed to override your body and brain's ability to eat in moderation. 13:50 96% of Americans are metabolically unhealthy. Food stamps are spent mostly on soda. 16:15 Insulin stops your body from burning fat for fuel. 19:10 Start with high animal protein and high fat foods that you can afford.  24:10 Metabolic labs: CBG panel, blood glucose, electrolytes, A1C, fasting insulin, triglycerides, HDL/LDL. 26:15 Continuous glucose monitors give real time feedback.   28:40 The national target A1C is under 7%, which is very high. 30:44 Damage is taking place with 6.5% A1C.  32:30 High protein consumption does not drive blood sugar.  34:10 Vegans and vegetarians have higher rates of mental health issues.  38:30 Nutrition drives mental health.  44:30 Ultra-processed carbohydrates spike glucose and alter the neurotransmitters in your brain.  55:00 Ultra endurance burns stored body fat, for Michelle as a low carb athlete.  01:03:20 Carb loading is best done after your last workout before the event.  01:06:30 You need more protein as you get older.  01:12:40 Spread your protein consumption throughout your meals. Only eat 3 meals.

Please Subscribe and Review: Apple Podcasts | RSS Submit your questions for the podcast here News Topic: CDC: New COVID-19 Hospitalizations Increase Nearly 16% Vinay Prasad: Do not report COVID cases to schools & do not test yourself if you feel ill Show Notes: Early and late long-term effects of vasectomy on serum testosterone, dihydrotestosterone, luteinizing hormone and follicle-stimulating hormone levels Questions:    30 Day Reset - Loss of Appetite Julie writes: Some personal info: I'm a 40 year old female. 5'3." BMR is 1,542 (based on a calculator I found using the google machine). 199 pounds. On September 1, I started the 30 Day Reset. During July and August, I was more conscious about what I was eating and lost 18 pounds. While doing that, I read Wired to Eat and decided to use September for the 30 Day Reset. Today is September 4, so this is just my 4th day on the reset. Yesterday morning I woke up hungry (which is abnormal for me), but I waited about two hours before I ate breakfast because that's what I'm used to. After getting my day started, I wasn't feeling hungry anymore so it wasn't a big deal to wait to eat breakfast. I typically wake up, I lift for about 30 minutes, some days I take a walk for 1-2 miles, then shower and eat breakfast. I don't normally feel hungry until a couple hours after waking up. Aside from waking up hungry, yesterday and today I have had almost no appetite. Because I lift, I feel like I should be getting a good amount of protein in my diet. Typically I would be eating 25-35g of protein per meal. I had a packet of salmon and some green beans for lunch today, and I basically forced myself to finish so I could get the protein I feel like my body needs. While I'm not trying to make any hardcore gains during the 30 Day Reset, I don't want to lose any muscle mass while I go through this. It just seems like yesterday and today, after I take a few bites of my meal, I'm no longer hungry. So, my questions: Is this loss of appetite normal or should I be concerned that I'm not eating enough? For the past three days, I've been eating 850 - 1,100 calories. Should I eat more even if I have to force myself because I'm not hungry? Thank you!   DIM Supplement Causing Sudden Decrease in HDL Susan writes:  Hi Robb and Nicki, Longtime listener... maybe since 2009 ~~ Paleo Solution w' Robb and Greg. Good stuff. As a spry 20 year old in about 2000, I started the Atkin's diet and transitioned to clean eating around 2008. My total cholesterol has always been ~200 and split 50/50 - HDL/ LDL. I've had it tested dozens of times over the years. I've been the same weight since my teen years immediately went back to that weight post pregnancy. My body fat by hydrostatic testing has ranged from 17% - 21% throughout my adult life, with it being more near 17% in my later adult life (more self control about calories I think). I lift weights with intensity 6-7 days per week and keep my calories between 1600-1900 per day. Daily Supplements: Magnesium Vitamin D Cheap little multi Fish Oil DIM I am now 44. I just got my fasting bloodwork done, and my HDL has dropped from 100-110 to 77. My LDL has gone from 100 to 149. Two things have changed in my lifestyle: The addition of the DIM supplement last summer. Before taking DIM, I had horrible perimenopause symptoms. I was waking up in the middle of the night so drenched in sweat that I would need to take a shower. If I wasn't drenched, I was nervous, stressing, mind-spinning and not sleeping. 100% of my symptoms are gone since starting 300mg of DIM before bed.   Simply in an effort to keep calories under control, I've entirely cut nuts out of my diet (I used to eat tons), and I eat a lot less red meat than I used to. I also have started to sometimes eat fake foods, like protein bars, which I never would have previously touched. I've been feeling pretty good, crushing it at the gym, staying lean and mentally pretty clear. So, I was excited to get my bloodwork back. Low-and-behold my LDL is up and HDL is way down. It hasn't been below 100 in the last 20 years. So, I consider this a sudden drop. Also, my kidney function is looking pretty mediocre. eGFR = 81 (sodium and potassium are off too) In any case, my family tends to drop dead like flies at a pretty early age due to cardiovascular disease (skinny little Irish smokers). So, this sudden fluctuation in cholesterol is pretty scary to me. Dr. Google says that taking progestins may cause HDL to drop. Dr. Google also says that DIM causes an increase in progesterone. My question is.... Do you theorize a tie between the DIM supplement and my sudden drop in precious HDL? As a very active person with a 90% clean diet, should I care? The other 10% is protein bars and Chardonnay. There is very little to be said about the long term affects of DIM out there on the interwebs. So, I'm interested to hear your thoughts on it. Thanks! Susan   Vasectomy Research Trevor writes:  Hello, my question harkens back to THRR episode 063. A question was asked about getting a vasectomy. Robb, you referenced someone you know who found research that indicated negative hormonal consequences (less testosterone) following vasectomy. I find myself in the same situation now as a 44 year old over-fat dude considering vasectomy for birth control. My wife has used hormonal birth control methods during our marriage. Now her functional medicine Doctor is encouraging her to cease her hormonal intervention to work on some health concerns. Before I run my business into a scalpel, I'd like to know the potential hormonal risks I'm facing. I've done my amateur keyword searches on jama.org and pubmed, but I can't seem to find the research you mentioned in that episode. The conventional health articles say lower testosterone is not a risk. Can you help me find the research you mentioned? Or some tips on “how to fish” and do better research on my own? Thanks for all you two do! Trevor   Sponsor: The Healthy Rebellion Radio is sponsored by our electrolyte company, LMNT. Proper hydration is more than just drinking water. You need electrolytes too! Check out The Healthy Rebellion Radio sponsor LMNT for grab-and-go electrolyte packets to keep you at your peak! They give you all the electrolytes want, none of the stuff you don't. Click here to get your LMNT electrolytes Transcript: Coming soon...

Go here to see the full show notes: https://antiaginghacks.net/podcast/lipids-cholesterol-apob-hdl-ldl/  [Sponsor Message: If you are looking to get thicker, fuller and longer hair, make sure to check out https://fullyvital.com] Here are the items of discussion on this podcast: - Dr. Thomas Dayspring Background  - What Are Lipids?  - What Is Cholesterol And Benefits and Risks  - What are Glycero Lipids?  - What Are Phospholipids?  - What Are Lipoproteins?  - Important Lipoprotein Category Apolipoprotein B or ApoB  - Lipoprotein Bioavailability in Plasma  - Best Tests for Lipid Concentrations - Other Tests Dr Dayspring Prefers  

Questions In Order:0:55 What supplements to use to get the most out of your Hyperbaric Oxygen Therapies?8:35  Testosterone Therapy for ex-athletes and law enforcement who function in high stress environments and still want to perform at a high level? What are healthy testosterone levels?13:15 Proper sequencing in cocontractions drills within the training session and in the training periodization? What is cocontraction?19:27 Thoughts on hygiene products to get rid of toxic products?25:14 What are your thoughts on night shade vegetables (tomatoes, peppers, eggplants, white potatoes) very common in latino diets, interested in Doc's thoughts?28:25 What are your thoughts on peptides? If you suggest using them what are the best ones to be combined or to be used individually?36:30 What are your overall thoughts on cholesterol? Total vs HDL/LDL individually? Threat of high cholesterol? How to keep low cholesterol while eating high fat diet?40:45 Is deuterium a concern with nutrition regarding mitochondrial health long term? If so should we be in a low carb state the majority of the time? 45:25 At what point did you both realize you wanted to be a doctor in your respected fields? Was there a light switch moment?53:58 Recommendations for programming and training for Rugby, how would you stack lifting and running?1:00:05 Best test to access gut health? Favorite dietary strategies or probiotics to improve overall dysfunction?1:04:19 Thoughts on Chorella supplements?

Nuova rubrica "Il Trillo del Cardillo" dedicata all'interpretazione delle analisi del sangue e ai parametri che possono essere utili da monitorare prima di trarre delle conclusioni affrettate o spaventarci quando vediamo i famigerati asterischi sui nostri referti.

另一方面，作为范本的人类遗传疾病，是一个相当极端的情况，所累积的胆固醇量跟一般人根本不在同一个范围。更重要的是，道种疾病是患者先天性胆固醇代谢异常，跟饮食摄取完全没有关系。一般情况下，我们用餐后，饮食的脂肪和胆固醇经过消化，会包裹成乳糜微粒进入血液，将脂肪酸和胆固醇送到需要的组织使用，或带到肝脏去处理。就像下方这张图所表达的，乳糜微粒被肝脏吸收后，会转成含有90%脂肪的极低密度脂蛋白（VLDL），VLDL密度很低、体积大，基本上漂浮在血液里，不会沉淀在血管壁内皮细胞的缝隙。随着脂肪酸在血液中释放，VLDL在“脱脂”后成为含有80%脂肪的低密度脂蛋白，将胆固醇带给需要的细胞。LDL经过一再地“脱脂”，密度变高，也就成为含有40～65%脂肪的高密度脂蛋白，将胆固醇载回到肝脏回收再运用。一般人会将高密度脂蛋白HDL称为“好”胆固醇，而将低密度脂蛋白LDL称为“坏”胆固醇。但HDL和LDL就像上图所表示的，只是运送胆固醇的载体，它们和胆固醇都是身体所需，本身并没有好坏之分。HDL主要将胆固醇送回肝脏去回收，而LDL则是承载胆固醇，由肝脏出发前往身体各处去修复组织，说胆固醇是救命的分子，一点都不为过。过去的专家只因为LDL会在发炎的地方出现，就把它认定是“坏”的胆固醇，这种说法就像把出现在火场救火的消防队员当作放火的现行犯，完全是错误的标签，倒果为因。就正常的生理运作来说，胆固醇对于修复细胞膜的完整和功能是必需的。现在也有愈来愈多研究发现，身体受病毒感染时的激烈免疫风暴，和少了胆固醇的作用，有很大的关系。身体如果有发炎的情况，LDL自然会提高，这是因为身体修复而需要，这时需要的是找出发炎的原因，帮助身体减轻发炎反应。一些抗氧化的饮食，像是含有微量元素硒的巴西坚果，或有各种多酚类的姜黄、姜、羽衣甘蓝、亚麻籽、印度醋栗都可以帮助身体降低发炎的负担，反而能让LDL胆固醇降下来。身体如果转向采用脂肪作为热量，像是断食或生酮饮食，也会提高总胆固醇的数值，这是进入脂肪代谢自然的现象。但我们并不需要为个别项目数值提高而担心，重点还是比例，总胆固醇与 HDL的数值比例就是一个可以参考的实例。无论个别数值高低，两者的比值小于一定数值（例如3.5或4，要同时考虑性别和其他风险因子），就代表还在安全范围内。若三酸甘油酯高，HDL低，那么心血管疾病风险是高得多。另外，也要注意omega-6和反式脂肪偏高的情况。已经有研究指出，比起胆固醇，用一个人血液中omega-3与omega-6的比例作为指标，可以更好地预测心脏病发作或致死率。现在一般人只注意单一项目的数值，一看到总胆固醇或LDL的数字偏高，就想用药物把数字降下来，而忽略了整体的状况，甚至因此造出肌肉和肝脏更多的损伤、二型糖尿病、记忆退化、乳癌等问题。只从单一指标看健康，就像从钥匙孔想看清门外的全貌。是的，你所看到的现象是真的有，但是不是有足够的代表性？在整体的角色又是什么？这样的问号一定要保留在心中，才不会让自己走偏。几十年来，为了大众的健康，我需要不断做这么长篇大论的解释，只能感慨现代的饮食指南竟然可以错到这个地步，为了一个轻率的“饮食脂肪 →心脏病”假设，把这么重要的营养素排斥在健康饮食之外。人类认为自己的努力可以克服自然，这种一厢情愿的观点，并不符合事实。我们已经看到一个世代的人为了克服疾病，造出一整套饮食指南，结果不但没有带来解答，还将错误面扩散得更广，也许几个世代都修正不回来。回到科学的讨论，研究结果本身不是什么问题，问题是我们想要将一个复杂多层面的现象简化到单一个层面，甚至希望简化成单一个因子，也就当然造出扭曲，甚至扩大成时代的误解。这三张图，分别是1984、1999和2014年《时代》杂志的封面。透过媒体的聚焦，反映专家在不同年代对胆固醇和饱和脂肪的看法。美国的专家从1960年代开始，排斥动物性饱和脂肪，1980年透过政府发布饮食指南，到了1984年透过媒体提醒大众别再吃蛋和培根。1999年，胆固醇首先得到平反，《时代》杂志封面提示我们可以安心吃蛋。到2014年，主流媒体开始意识到，或许过去对脂肪的想法全都错了。然而5、 60年留下的印象，并不是一夕之间能消除的。当时我回到台湾，和在美国面对的情况一样，许多专科医师对于我鼓励摄取饱和脂肪，不需要害怕胆固醇的说法，非常不以为然。现在又经过了这么多年，有些医师已经在默默修正自己的观念，但还是有些医师仍然坚持自己的观点。专业人士都已经是如此，根深柢固落在大众心里的观念要修正，更是需要时间。我才会放慢脚步将这些论点一点一点陈述出来，你只要愿意拿自己做实验，观察自己健康的变化，早晚会得到你自己的结论。—摘自《疗愈的饮食与断食》—————————————作者：杨定一博士播音：张婉琦背景音乐：瑜珈练习音乐

On this weeks episode I sit down with the legendary Jonny Bowden.  Jonny Bowden is a pioneer in functional nutrition and his books have been apart of my library since I started in this industry.  Jonny well known for his book best selling book, "The Great Cholesterol Myth," which we break down in this episode.   On this episode we cover: How the country got on the low fat kick  Cholesterol  Modern cholesterol test  Why the HDL/LDL test is antiquated  The particle test  How to test for cholesterol the modern way  What to ask your doctor  Why statins don't save live  Link between statin drugs and erectile dysfunction drugs  Cholesterol and sex hormones Pre-Diabetes aka Insulin Resistance  Fats  Vegetable Oils vs Seed Oils  Omega 6s and Omega 3s Inflammation Check Out Jonny: Website Jonny's Instagram: @jonnybowden Sponsored By: Dr. Tyna Store Use Code ULTRAOMEGAOK10 For 10% off Ultra Omega OK Follow Dr. Tyna: Instagram  Download my FREE book and get on my email list Shop my stores: Dr. Tyna Store and Dr. Tyna Hemp Store Further Listening: The Functional Pharmacist: Statin Drugs with Dr. John Kim Show Links Statin adverse effects : a review of the literature and evidence for a mitochondrial mechanism Sickening Prescribing By Numbers

On this episode we shared with our listeners about HDL, LDL, andother important components of Heart Health.  Heart disease is the leading cause of death for both men and womenin the United States. The good news? It is also one of the most preventable. Americasnaturaldoctor.com

「高HDL・低LDL血症」（解説）自治医科大学 内科学講座 内分泌代謝学部門 准教授　岡﨑啓明氏（ききて）防衛医科大学校教授　池脇克則氏

本集節目由娘家大紅麴贊助播出 娘家 #支持你的堅持 #照顧你的健康 娘家大紅麴 #國家雙認證 給你最大的信任 不含莫納可林K (Monacolin K)更安心 唯一通過美國FDA新膳成分通知上市 有助提升好的膽固醇HDL 有助降低總膽固醇、壞膽固醇LDL及三酸甘油酯 有助調節血糖、血脂 雙12最殺金喜立即購 娘家官網： https://pse.is/3u9znh 立即來電訂購：0809-035-888 娘家熬雞精58入 x 小戴聯名行李箱 在人生旅程中，隨時讓自己元氣一下 一起為正在備戰世錦賽的小戴加油 預購方式:持條碼至7-ELEVEN門市櫃檯結帳 商品預購期間:即日起~111/2/6 最快取貨日:11/20起，原店取貨 本週新聞重點： 00:03:32 不能被叫Xi的Omicron 00:16:51 台灣在國際舞台正當紅 00:37:06 民主剛果的中美鈷礦戰 00:59:22 宜蘭小旅行 班比山丘 舊書櫃 廣告合作請來信 mindyworldnews@gmail.com

Dr. Scott and Tommy dive deep into cholesterol and how fasting affects bloodwork numbers in the short and long term. There are many misconceptions and evolving guidelines for cholesterol and determining risk for cardiovascular disease, which also vary in different parts of the world. These topics are discussed with a focus on optimizing health through fasting. https://www.health.harvard.edu/blog/farewell-fasting-cholesterol-test-201606169784 https://betabios.com/debunked/cholesterol/remnant-cholesterol/   Have a question you'd like us to answer? Click here to send it to us or leave us a voicemail we can play on the show!   Show Transcript: www.thefastingforlife.com/blog   If you enjoy the podcast, would you please tap on the stars below and consider leaving a short review on Apple Podcasts/iTunes? It takes less than 60 seconds, and it makes a difference in helping bring you the best original content each week. We also really enjoy reading them!   Sign up for the Fasting For Life newsletter at www.thefastingforlife.com   Join the Community on Facebook!   Follow Fasting For Life: www.facebook.com/thefastingforlife www.instagram.com/thefastingforlife

On this episode, Dr. Tom Dayspring and Faraz Khan discuss the basics of lipids that you need to know about: 1. What are lipids and lipoproteins? 2. Why is cholesterol very good for you - and very bad for you - but here is how to know which one you have? 3. How to review your lipid numbers after your next blood test - plus 1-2 secret tests you MUST start getting from now on. Get the full show notes here: https://antiaginghacks.net/podcast/lipids-cholesterol-apob-hdl-ldl/ Thomas Dayspring is a Fellow of both the American College of Physicians and the National Lipid Association and is certified in internal medicine and clinical lipidology. After practicing in NJ for almost 40 years, he moved to VA and served as an educational director for a nonprofit cardiovascular foundation and later as a Chief Academic Advisor for two major Cardiovascular labs until mid-2019. Currently he is a cardiovascular educational research assistant & clinical lipidologist at Attia Medical. Career-wise he has given over 4000 domestic and international lectures, including over 600 CME programs. Until 2019 he was an Associate Editor of the Journal of Clinical Lipidology. He was the recipient of the 2011 National Lipid Association's Presidents Award for services to clinical lipidology. He is very active on twitter and has well over 15K followers (@DrLipid)

1-888-454-8464 https://healthyinformation.com/ askthedoc@healthyinformation.com Hello everyone this is Dr. Whiting and today were going to be talking about cholesterol and cholesterol is one of my favorite subjects because it is so badly misunderstood and today is a very special day for men to be talking about cholesterol HDL LDL high cholesterol functions of cholesterol and so forth and what makes this so exciting for me is I have been teaching people or trying to teach people for years that cholesterol is not your enemy in fax it is so important that your body manufactures the vast majority of cholesterol and it’s in your body at any time and it does so in your liver up to 80% of the cholesterol in your body is made in the liver 20% maybe comes from diet well the reason why I’m so excited is because the industry the health industry the medical industry the dietetics industry has finally started to come around and in an article that appeared on CNN and in other places it has been picked up now admits that dietary cholesterol is not a significant risk factor for heart disease finally how they don’t go all the way in the article they don’t talk about the real cause of heart disease but at least they’re admitting that cholesterol may be isn’t the enemy that we thought it was you see cholesterol has so many functions in the human body it manufactures hormones it lubricates your arteries keep some flexible it forms the myelin sheath around all the nerves in your body something so important that nature make sure that we have adequate cholesterol by manufacturing it inside the liver they have finally admitted in a meta-analysis study of several studies which appeared in of all places for the American Heart Association that dietary cholesterol plays virtually no factor whatsoever in your risk factor for heart disease and this is bittersweet for me because I’ve been trying to teach people this for over 40 years and finally after all the fighting and arguing that I have had to go through with the industry they’re finally admitting that we were right it’s an interesting time and in a way it’s sort of sad because if I think about the millions of people who perhaps were put on dangerous statin drugs driving their cholesterol dangerously low and it was probably for the most part unnecessary you see dietary cholesterol work sort of this way if you eat a diet that’s high in cholesterol containing foods and healthy liver should reduce its production of cholesterol internally to compensate when we see somebody who has a total cholesterol level of 250 or more what we’re seeing in fact is a liver problem not a cholesterol problem not a diet problem and when the liver becomes laden with fat or it becomes toxic than at the end result is that it cannot always do the job that is supposed to do namely regulate of lot wide variety of fats and hormones that it produces so when we see somebody with elevated cholesterol what we need to do is address the liver and we can do so by detoxifying the liver by providing key nutrients to support better liver function and so on and so on and when we do that cholesterol oftentimes comes down all by itself doctors for decades have been putting people on low-fat low-cholesterol diets and the end result is a temporary improvement after which cholesterol levels rise again because your liver is trying to compensate for the missing cholesterol from diet so the only way to control this is to address liver function and we can do that quite easily on we have been very successful in normalizing cholesterol levels.

In this episode, we discuss all things cholesterol. We discuss why cholesterol is important, optimal levels, and much more.   You can subscribe on iTunes or any podcast service of your choice, via an RSS feed, and on YouTube. Just search "The Well Man's Podcast" and you'll find our page. We'd love to hear what topics and discussions you'd be interested in hearing, or what aspects of your health you want to improve most. Check out old episodes in video form: http://bit.ly/TWMPUTube Follow & reach out to Keoni at: @KeoniTeta nhcnc.com Follow & reach out to Bryan at: @BBrozy https://bwellptfl.com/; You can also subscribe to Bryan's mailing list to get actionable health information delivered right to your device by clicking here: http://bit.ly/2miS0iF Please email us at wellmanspodcast@gmail.com, telling us how we can best serve you!  https://www.facebook.com/The-Well-Mans-Podcast-555112064834290/ https://www.instagram.com/thewellmanspodcast/

Bölüm 26 - Bu bölümde düşük karbonhidratlı ve yağlı beslenme ile kolesterol ilişkisini konuştuk. *Kolesterol nedir? *HDL ve LDL nedir? *LDL gerçekten kötü kolesterol mü?

Triglycerides and HDL are critical to our health, so knowing them should suit us well. In this podcast, let's discuss:Drs. Attia & Dayspring's discussion about lipids & TG/HDL ratio;What a triglyceride (TG) is;What high-density lipoprotein (HDL) is;The connection between prediabetes & TG;How TG affects HDL & LDL;What remnant cholesterol is.For more information, contact us at 859-721-1414 or myhealth@prevmedheartrisk.com. Also, check out the following resources: PrevMed's blog articlePrevMed's websitePrevMed's YouTube channelPrevMed's Facebook page

1:24 Intro to nutrition's impact on cholesterol 4:00 Negatives of butter in coffee 7:47 What does high cholesterol mean 12:31 HDL- LDL ratio 17:40 Meat consumption and cholesterol 20:08 Total cholesterol acceptable range 24:47 Cholesterol and genetics 30:20 Spencer's patient with 4 heart attacks by age 30 33:36 When should medication be prescribed 38:45 Doctors not caring 41:10 Lifestyle changes to lower cholesterol 47:09 Mono and polyunsaturated fats 48:30 Diet improvement examples 53:47 Weight loss impact on cholesterol 56:45 Exercise effect on cholesterol 59:18 Other factors that may affect cholesterol 1:01:18 How to learn more about cholesterol

Liz & Kathrine @passionforplants discuss how leaning into a more plant based diet can reduce your carbon footprint and how each of our contributions matter. Open your mind! Consider the way your diet impacts YOUR life and consider how you could possibly make an impact in a positive way with these choices. Explanation of HDL & LDL cholesterol/risks via the way we eat. Description of the Blue Zones and where/how people live comfortably until old age. Must Listen To's: The School of Greatness Podcast with Dr mark hyman - Build Your Health to Build Your Wealth & MindBodyGreen Podcast - Ep 121 How to Heal Yourself with Dr Kelly Turner

Remember, I am a real doctor Eric is a real crna. We do do real medicine. But this show is not intended to diagnose or treat. Please, if you have any issues like rectal bleeding, go to our website, kbmdhealth.com. Download the E book, learn about it, but make sure that you talk to your doctor about it.Ken Brown   All right, here we are with the gut check project, Episode 29 a super special episode because we have a guest co host, Eric Rieger was unavailable. And so we had a guest co host today it is Dr. Doug Won, who's here. Welcome to the studio, my friend.Dr. Won  Thank you so much for having me here. Truly an honor.Ken Brown  Well, I think that this is gonna be a really really cool show. You're doing A lot of functional things you're really big into treating the whole person. Your background, I think is really cool. I am gonna warn you though. I hope you're a pretty smart guy because Eric's a smart guy. You got some big shoes to fill in. So why don't we at least find out like if you're, you know, like where you actually came from and everything. Tell us a little bit about yourself?Dr. Won  Sure. I'm from South Korea, immigrated to Irving, Texas when I was 11 years old and went to elementary, middle school and high school in Irving MacArthur High School, go Cardinals. And then after that, I went to Northwestern University. I majored in biology and biomedical engineering, and then went to medical school at utmb in Galveston, and once I was done with the medical school, pursued orthopedic surgery at Washington University in St. Louis, and did spine surgery fellowship in Michigan, and then came right back to Irving, Texas, to treat my friends and family members and my local community and Irving, the city that I love, I went back to it and been there ever since.Ken Brown  Yeah, you're way smarter than Eric. Yeah. Of course right now he's probably arguing I didn't hear anything about Texas Tech. So you know, so in his mind, you didn't go to Texas Tech. You're not nearly as smart. But I guess you did say a few other things Northwestern, double major biology, biomedical engineering and everything. So, yeah, I think that I think the show is going to be really great. What I want to do with this show today, you have you and I have very similar passions. We're really big into the functional medicine side of things. I want to cover some anti aging stuff. I want to talk about how supplements and nutrients can actually augment a lot of these different things that talk about your past. Now. You are one of the most accomplished orthopedic spine surgeons and I can I have to pick your brain before we even jump in. I was actually talking to a very difficult patient of mine and I wanted to throw out a disease and just see if you've ever dealt with any of this. I believe That we have somebody who is smoldering into ankylosing spondylitis. Now this actually happened to one of our co workers, but now I'm treating somebody who's acting a lot like she did. She spent about two years just sort of, you knew something wasn't right. And then pow it just kind of all popped up. Have you had some experience with autoimmune diseases and stuff like that specifically as ankylosing spondylitis?Dr. Won  Yeah, absolutely. In our spine clinic, we used to see a lot of patients with ankylosing spondylitis. And then also patients who didn't quite have the the conditions, but they were HLA 27 positive, and they were brewing the different types of symptoms and conditions. And then we also deal with because I also deal with lifestyle medicine. We've actually seen a lot of different kinds of patients with autoimmune disease. And what we usually tell patients is that your genetics and genes may load the gun, but you actually pulled the trigger through your nutrition and lifestyle.Ken Brown  i like how you say that. Yeah, totally. So one of the things I just want to get this out of the way that you You're a very accomplished orthopedic surgeon. You're currently involved a little bit of a legal situation that you're appealing. What I think is amazing what you have done is because you have to put your surgical practice on hold for a little bit. Yes, you have shifted, and have still taken on the role of being a doctor, helping people and being an educator, you have not slowed down at all, you are the embodiment of resilience of moving through. I'm super, I think that's really, really neat. And why did you decide to kind of shift gears, I mean, you were going from scalpel. And I get that you have to take a little break from that. But a lot of people like you would just say, I'll use this as a break to go tour the world and say hi to things and you went I'm gonna use this as my opportunity to help more people.Dr. Won  Thank you. You know, helping people and making a big impact was my passion. That is a reason why I went into medicine and went into medicine because you know, my father suffered from back and he had four back surgeries, and his life was ruined for about 30 years with severe pain and in life You come up with so many different challenges. Either you can crumble or or decide to just sit back, and then the life continue to punch you, or you can stand back, you know, stand up again, and continue to move on forward. And what got me going was as long as I can make an impact and help all the patients, and my passion was biohacking, which I've been doing, you know, all my life. And what I realized was that in medical school, we really didn't learn how to cure the disease. We learned to manage the disease. And through this experience, I really learned how to better manage and then in many incidences, and cure the patients, and wanted to continue to make an impact and help patients. That's what gets me going and that's what's getting me up every single morning. And no matter what anybody says, as long as I feel good about you know what I'm doing and continue to practice medicine in different way. Through health coaching, and, you know, even approaching and these days, I also teach a lot of doctors in Africa. How to treat chronic disease.Dr. Won  You teach doctors in Africa?Dr. Won  Yes. Ken Brown  Okay. I got a segway out of that for a second. What? Tell me about that? Dr. Won  Yeah, so I came in contact with a physician who was really into preventive medicine. He's a personal doctor to the president of Cameroon. In Africa right now, they're facing so many different chronic disease. In the past, before the Africa became developed, there was no such thing as heart disease, cancer, diabetes, or obesity. But as the countries are becoming wealthier, and countries are becoming more developed, they're now importing American disease such as heart disease, diabetes, cancer, Alzheimer's, and they obviously can't afford to treat the patients with American medicine. So they're looking for ways to treat the patients naturally, and also the citizens most of the people in Africa are still hesitant about Modern medicine. So we got in contact through a mutual friend. And we decided to teach the the physicians there, how to reverse the disease naturally. And then also importantly, to prevent them.Ken Brown  Wow and so are you doing some sort of zoom with them? Do you have a lecture series? How are you doing this? Dr. Won  Yeah. So every Saturday morning, I connect through them through zoom meeting. Thank goodness for technology. I don't have to physically be in Africa. I would love to visit the continent, sometime soon. When things free up, but utilizing the technology, we provide the lectures, mostly to physicians, but also just about anyone who's interested. And we open it up to the whole community. And at one point, we had people from seven different countries connecting seven different countries in Africa.Ken Brown  Oh, wow. That is that is fantastic. So even before you had to kind of take this little hiatus from actually cutting on people and doing spine surgery, you've been thinking about this for a long time. You've been working towards the changing, changing the disease progress, you made a living for many years taking care of the end problem of people having wearing their bodies down, then you as the spine surgeon go in, and you take away their pain and you help them. But even then you were thinking, and what can we do to prevent this?Dr. Won  Yes. Oh, absolutely. So we've been giving free seminars on how to prevent and reverse chronic disease naturally, for about three years. I initially did not necessarily want to give the seminars myself, I'm not a good public speaker. And so I wanted to set up the infrastructure and then invite one of the physicians to do it. And he did it in a couple of times, but it took him away from the family. And it takes a lot of effort to prepare different topics. So I thought this was so important. And as you know, when we're in medical school, maybe we had an hour or two hours of lectures of nutrition, and how to reverse the disease naturally. Well, actually, we didn't learn anything about how to reverse the disease naturally in medical school. We learn how to just manage the disease. And so once I saw the light, I said, I have to share this information with everyone as many people as possible Ken Brown  Even as a gastroenterologist when I trained as a fellow, it is called the division of gastroenterology and nutrition. And I think we got like, half hour a week on nutrition. I know that it's supposed to a split the title. Gastroenterology and nutrition.Dr. Won  Yeah. And look at the hospital. You know, once I had a patient after a very big surgery, and he had a mild, MI you know, mild heart attack. And the next morning when I went up to the patients for patient had eggs, bacon cheese, for breakfast and lunch, I said, this is wrong, and then go to any hospitals, whether it's Dallas or anywhere else, go to the cafeteria, the hospitals are serving disease causing food in the cafeteria and to the patients. I said this is wrong, right. That is the true crime. And I said, you know, it was one of our mission to to really empower the people and teach me How to Prevent and reverse the disease themselves.Ken Brown  We should do a video where you actually come to my hospital to the doctors lounge. They give free food to the doctors and you walk around that doctors lounge. There's bags of m&ms. I've taken pictures of this. There's m&ms there's, this is really funny. There's actually bowls of like gummy bears. And I'll watch and people will just go by just grab a head. Start eating on the way out. I'm like, there's so many things wrong with that. Not just the food, but a lot of hands been in that bowl.Dr. Won  Yeah, actually, I got in trouble with that one of the hospitals here locally in Dallas I actually took a picture of what they were serving at the doctors lounge and then post it on the social media. Oh, and then I got called into the principal's office. The hospital CEO.Ken Brown  Oh, before we get called into the principal's office, since I'm not good at this part. This is what Eric does real well. One thing disclaimer both Dr. Won and myself are real doctors yet this is not intended to treat anybody or give any medical advice if you have that unusual rash or joint pain or anything, this is not here to cure or treat you. But this could help cure whatever it is or not, or at least reverse what's going on by lifestyle changes, not through medical advice. And the other thing that we always need to do is really give love to our sponsors. Our sponsors Atrantil my baby, my little polyphenol complex, which we're going to get into a lot of stuff about this because Dr. Won is a whole food plant based doctor. And those vegetables all have polyphenols similar to what we have, in Atrantil. And we do know that that actually can work like the Mediterranean diet, and do all different kinds of things. And of course, the KBMD health CBD, I'm a big fan of cannabadial, we get into the science of it, we're going to learn more and more. I don't know if you've gotten too much into that. But the one thing that we talk about a lot because I start meeting scientists, like we have discussed before when you have when doctors say there's no science and then you're meeting the bench researchers that are out there. There's gonna be a field like you're an orthopedic spine surgeon you're a subspecialty of a subspecialty. I'm a gastroenterologist I'm a subspecialty of a sub specialty. I guess yours is sub sub sub because you did spine after orthopedic. Your your next level, even though you didn't go to Texas Tech, we're gonna forgive you for that. Dr. Won  Thank you. Ken Brown  Yeah, that's, this is just for Eric because he gets so upset if we don't discuss that. But even when you're sitting there as a sub sub specialist, we've got all these people with knowledge in other fields, that then you start realizing you could be a sub sub specialist. So I've met researchers that I call Endocannabinoidologists because they understand so much on the molecular basis of the endocannabinoid system, which I think eventually we're going to get to, but I think all of it gets corrected if you eat right and live the right lifestyle. So our little disclaimers go to Atrantil.com or go to KBMdhealth.com and take a look at the CBD. So that's usually a Does that a whole lot smoother? That's not really my...Dr. Won  I think you did great. Ken Brown  We have to get that out of there. So, all right, getting back to you, because I this is a rare opportunity to have somebody with both your background, your your skill set. And now this this continual pursuit, this continual change. I'm very similar to you, I've realized at this stage of my life, that moving forward is what keeps me happy. Always trying to see okay, what what can we do? What can we do for the next thing? What can we do for the next level? I try to always talk about a recent news article or something and I want to bring this up. Not to put you on the spot. Dr. Won, How old are you?Dr. Won  I am 48 years old.Ken Brown  You don't look it 48 years old. Awesome. An article just came out out of the National Bureau of Economic Research, which takes on the myth that life begins at age 40. This is kind of interesting, according to this very large study, that they looked at over 257 different countries, different socio economic stages and all that. Fascinating that you're saying that Africa is now getting these Western diseases Dr. Won  Yes. Ken Brown  So it's it's, it's impervious to everybody. The whole world is having the same crisis that I think we face. We just got there a little quicker than everybody else. Dr. Won  Oh, absolutely.Ken Brown  What they looked at is that there is a U shaped curve for happiness. And as it turns out, it bottoms out at age 47.2. And the reason why I bring this up is that there's a lot of people and they were trying to figure out why is it genetics? Is it that the stressors are too much? Is it that disease start setting in right about then you start realizing your own mortality and all these other things. They don't know exactly why, but they were able to account for education, marital status, all these things. And they did show that although it bottoms out by 48 49, people are able to find their way out and they can usually do it through community and through purpose.Dr. Won   Yes.Ken Brown   So both you and I are beyond that now. So now we're in the happiness zone. And I think that you've done exactly that you got through a little curveball and you're like, I'm just gonna keep moving. and I'm going to do this through community and purpose. And what it sounds like, is that the first thing you did is say, I'm going to give free lectures. Tell me about that.Dr. Won  Yeah, so we've been hosting a free seminar, teaching people how to prevent and reverse their chronic disease, and through whole food plant based nutrition. And there's a it's not just in nutrition itself, but it's a whole lifestyle. And that's why we don't like to call it you know, plant based diet is a plant based nutrition and lifestyle. And what I realized was I started going into plant base once I lost a few of my colleagues to cancer, they're physicians, and I myself, always thought, Hey, you know, there's a chance that I might die from cancer and the reason for that is because I've done a tremendous amount of a minimally invasive surgery and use two interpretive X ray machines and, and got significant amount of radiation exposure.Ken Brown  Just explain real quick, minimally invasive and why you would have to be using an X ray machineDr. Won  So a traditional spine surgery, you would make a big incision, right and then open up the spine, take away the, you know, the fat, the fascia and the muscle and then strip all of them off and gain access to the spine. And the whole concept of minimally invasive surgeries, not disrupting the soft tissue, you would make a very small incision, and then utilizing the X ray machine at the time. Now these days, you can use imaging guidance with minimal amount of radiation. But when we were first starting out 15 years ago, it was the typical X ray machine. We were protected with Lead But still, we got a lot of exposure to radiation. So I used to joke around saying I'll probably die of cancer someday. But what I realized was that I don't want to die of cancer Who does? So I started doing just a lot of research how to prevent cancer. And I just, you know, went through about thousand different papers, scientific papers, I realized we all have cancer cells, every single one of us have cancer, so we have cancer. So when we're diagnosed with cancer is a clinically significant cancer that we which we can prevent In many times and reverse, even the study from the MD Anderson state state study showed that number one cause of a cancer was diet. Number two was the tobacco. Number three is obesity, which leads back to the diet, right? And then the genetics makes up the smallest percentage, you know, no more than five to 10%. So we actually have to controlKen Brown  Use your analogy one more time with a gun. I like that.Dr. Won  Yeah, it is the gene or genetic loads the gun, and then the diet and lifestyle pulls the trigger. And so in that we now with better understanding of epigenetics, that the the genes are like the light switches, depending on our nutrition and lifestyle, we actually have the ability to turn them on and turn them off. So So through that approach, I discovered whole food plant based nutrition, which has worked wonders for me, instantaneously, within six weeks, I lost about you know, 25 pounds, and after age 40. They said if you do exactly the same activities level eat same thing. You're going to gain about a pound or 2 every single year, if you know then within 10 years, that's additional 20 pounds. And so starting 40...Ken Brown  I'm sorry to interrupt. I just want to clarify this one thing you chose to go plant based Whole Foods based on the thousands of articles that you researched. Dr. Won  Yes. Ken Brown  So you were not like watching Netflix and stuff. I'm going to I'm going to follow this what the health diet or I'm going to do the game changers This is based you are not influenced you did it all on your own correct?Dr. Won  Yeah. So I actually did it before all those documentaries came out. And the researchers were there. And and what happened was one of my friends from medical school, he came to visit me at one time and then he gave me a book called China Study. And I thought, maybe because he knew that I was also into business. This was about economics book. I didn't even see the cover. And then I kind of put it in the bookshelf and I forgot about it for a long time. And then once I started doing the research, there's a The China Study kept on coming up. And I said, Wait a minute, I think I have a book called China Study. Written by Dr. Campbell from Cornell, and now pulled it out, read it cover to cover, along with other studies, and then realize you can actually reverse the disease. And this has been the studies been going on, you know, there's been studies since 1950s. And so I was convinced I said, You know what, I'm going to do this for myself. And without even trying at first thing I did was wait is, you know, important, but not the most important thing, but I instantaneously lost 25 pounds. And I was back at the weight when I was in high school. And you haven't seen many you know, you don't most people think there's not too many, you know, overweight or obese Asians? Well, in America, there are plenty not and maybe not in Asia, and I was becoming one of them. And so instantaneously, I was back into my high school weight. And then I started exercising on regular basis, and I felt so much better and now I'm I feel better and stronger than when I was in high school. And until about, you know, three years ago, I couldn't even do a single pull up. And and now I can do quite a bit and my goal is by the time I'm 50 I'm going to be able to do muscle up.Ken Brown  Oh, yeah, yeah, for sure. Well, I got to actually Eric super into CrossFit. So he can teach you the whole technique on that. Dr. Won  That'll be great. Ken Brown  We can sit there and do that. It was on last week's show of the week before we actually discussed the fact that when coke really started penetrating China, that's really when their obesity problems started the high fructose corn syrup and all that Dr. Won  Oh, yeah. Yeah, all the the processed food, right. And then, you know, along with the, you know, meat consumption, and as a developed countries are getting wealthier and wealthier they're eating just like American Standard American Diet, right, all the processed food, all the sugar, all the the, you know, high fat animal products. Even in America, average Americans consume about 250 pounds of animal products every single year, which is a tremendous amount, right? And so, and then the China's Study...Ken Brown  How many pounds? Dr. Won  250 pounds. I thought that's a that's a lot right? That's average Americans since I'm I don't eat any somebody is eating 500 pounds of meat every single year right?Ken Brown  I'm gonna look at that cow and go. I'm gonna eat half of you this year. The whole cow.Dr. Won  That is a tremendous amount. I think they said also during the Superbowl, I don't know how they come up with the numbers. Every every year during the Superbowl people consume about 1.6 billion chicken wings. Oh my god.Ken Brown  1.6 billion chicken wings. Yes. For the for the Super Bowl. Dr. Won  Super Bowl. Ken Brown  All right. Yeah, that is a lot of wingless chickens running around.Dr. Won  Yeah, absolutely. And, and you know that the chicken these days doesn't look anything like the chickens from let's say even hundred years ago, because they're genetically modified, you know, and they have so much more antibiotics. They have so much more chemicals, growth hormones, and so people are so concerned about eating food that's not Genetically modified but most people in America don't know where the food comes from. And they don't really think about it especially when it's in a hamburger or chicken sandwich which they really do need to pay attention whether you're plant based or not, you should really know where your food comes from.Ken Brown  You know, I mean I love having you on here because even as gastroenterologist and even though I think like kind of we want to treat the whole body I've I have not spent that much time really going over the whole diet thing because I naively am like okay, this is the weight I want to be. This is kind of what I want to look like when I'm when I'm at the beach is you know, if I start not seeing the the ABS or we go from that six pack to the four pack to the two pack to the no pack. Then I just start working out more. Yeah. And I got a little rude wake up call. Last week I went to I have a functional medicine practitioner. His name's Kevin Wilson. It's smart wellness now. And you know, they they do real Like deep dive into the blood work so it isn't just HDL LDL, it's you know, it's LDL, C it's Apolipoprotein B, it's all this. And my cholesterol went up. I'm feeling better than I ever felt what? And he's like, yeah, you're doing something wrong, buddy. Yeah, and you know, and quite honestly, I'm pretty much paleo so i don't i don't really do dairy or gluten, but I will mowdown some meat. Got to eat my 500 lbs. So you got me rethinking. So he's given me three months to try and reverse this. So I'm starting a little bit slow and so I'm not I'm gonna start watching your videos for sure. Because I did the thing that most people do. I went and watch Game Changers on Netflix and and which is a very fascinating documentary in the sense that that got more traction than what the health and knives over forks and all those other vegan propaganda ones, because I think that they were talking about performance. Dr. Won  Yes, Ken Brown  What you're describing is exactly that you're you this is not an ethical thing. This is not a a conscious choice. You were like, No, I did my research this, I can be healthier.Dr. Won  Yes. I mean, I did this because for my health, and you know, I always tell people that I want to live until 120 years old, I may have had a better chance if I actually started when I was in my 20s.Ken Brown  You know, that will just be you. And Dave Aspy having tea together because he says the exact same thing on his podcast.Dr. Won  I think he says he wants to live forever. And so I don't know if that's possible yet. But they said he, if you do it, right, the kids who are born today have a potential to live until 150 years oldKen Brown  A hundred and 50 years old, have the potential?Dr. Won  Have the potential. But but the sad thing is the kids you know, between age 10 to 12 years old, what percentage of the kids actually have early signs of atherosclerosis? 75% Ken Brown  What? Dr. Won  75% of the kids between age 10 to 12 years old, have already fatty strix. Ken Brown  No! Dr. Won  They all found that the... Ken Brown  That's nuts there's no way! Dr. Won  Even the fetuses are now showing up. unfortunate event because, you know, whatever, you know, may have happened. But when they do an autopsy on fetus, even the fetus, some of the fetus actually have, you know, some fatty Strix, depending on Mother's, you know, a vascular system. Right? So, you're starting at life already having early signs of cardiovascular disease, what is that? Right? And so when mom said, you know, I'm really, you know, sensitive to listen moms who are pregnant, and then also parents, they have such a difficult, you know, challenges, you know, feeding their kids, but they're not really thinking about what they're serving them, right. And I cringe when I go to a breakfast, and then you know, next table, you know, parents are serving their kids bacon, or hotdogs, and the kids and the food that is known by World Health Organization as a group one carcinogen, right. So I think we need to really step back and educate the public and help them see what they're putting on their, on their table. And when I saw the article where the kids, you know, between 10 and 12 years old, 75% of them had already have signs of, you know, cardiovascular disease. I mean, that's terrible. We're not doing something right. And we spend so much money on managing the disease, which we don't do very well. But and, you know, completely forgetting about preventative medicine because there's no money in preventive medicine. Right? That's that was our mission is to actually go to community and and teach them how to eat properly. And so, so we've done not only lectures at our clinic, but also if anybody wants to hear us talk. We'll go and give a talk. And we've gone down to the south side and then the African American churches to church in Richardson at Methodist, you know, pretty much 99% Caucasian, you know, congregation. Or you know, community centers who wants to learn about...Ken Brown  You still have the guts to go to a nice Korean BBQ establishment and give a talk? I like Korean bbq man!Dr. Won  Yeah, you know, for whatever reason Koreans were known for Korean barbecue, but in Korea actually. Their health is declining like in China because the meat consumption has increased processed food, and then their lifestyle is changing. But you know, they used to be one of the healthiest country in the world, because they were too poor to actually eat meat. It wasn't available. Everyone wants to eat. So if you look at all the countries, all the cities and along the Blue Zones, the the cities that have the most amount of centenarians, most people are poor. So by being rich, yeah, you may have money to spend it, but you're actually ruining your health. Ken Brown  Alright. So I was going to ask you this, and it's a perfect it's a perfect segue right now. So I was talking to one of my patients today that she's going to be a guest here shortly what happens to have Crohn's disease and gives back to the community just like you she works as a counselor and does all this and she happens to be a speech therapist for underprivileged kids with autism. So part of this, you know, they, they send them with the with the school system. And so her and I started talking, I started talking about how last week we did a whole show on a chemical that makes plastic flexible, called DEHP you've been exposed to it a ton as a doctor. So have I that's what IV bags are. That's what the tubing is, all the catheters and tools that we use to be flexible so that we're not puncturing where we don't want to use this chemical dehp. And when you said in utero, they're finding stuff as it turns out in utero, if a if a woman is exposed to it, it just goes to the fetus and causes all kinds of stuff. Dr. Won  Oh, wow. Ken Brown  So what her and I talked about is I'm like man, well, what can what can you do to circumvent this autism at you know, I mean, basically epidemic She's like they're too poor to eat healthy. Dr. Won  Yeah. Ken Brown  So now you just said that when countries were poor, they ate healthier. So let's talk about the cost of, of living your lifestyle. Is it possible if I don't have a high income to eat a plant based whole food diet?Dr. Won  Absolutely. When people are thinking Whole Foods plant based, I think a lot of people get that confused and they think it's vegan. And then and they get meat replacement products, which are actually quite expensive. Right?Dr. Won  So when you do... Ken Brown  This guy did that when he watched game changers and it didn't work out well. Dr. Won  Yeah. Ken Brown  Because I think the either the fillers or the soy or something may be very inflamed. Dr. Won  Yeah. Ken Brown  So I backed off.Dr. Won  So one of the things I really you know, it's also talked to the vegan community is that you know, they've already given up the meat which is the one of the most difficult thing for a lot of people. However, they also need to get away from the processed food because most of the the meat replacement products are processed. So when you're eating a whole food plant based, you are eating non processed or minimally processed food. And so the best place you know, and the best pharmacy is actually with F, you know, FARMACY right Farmacy is in the produce section, that is the medicine, that's where people need to go shop. And so if you get dried beans, it costs pennies, right? Versus, you know, getting ground beef or getting chicken breast. So actually eating whole food plant based can be very, very inexpensive. That's why and along the the Blue Zones, the you know, like nicoya, Costa Rica, Okinawa, Japan, you know, Sardinia, and aquaria. All those countries, all those communities, people were relatively poor, they're not wealthy at all, even especially like nicoya they were eating mostly beans Ken Brown  Where's the Nicoya? Dr. Won  Costa Rica. Ken Brown  Okay. Dr. Won  Yeah. And it's one of the cities and Blue Zones that has the most amount of centenarians, right? And and there were most they're all 98% eating plants because they were too poor to eat meat. And they're living beyond and then they didn't necessarily go to the gym, you know, or CrossFit or 24 Hour Fitness, because they walked every day everywhere, they didn't have cars, right? So they're moving their body every single day. They're eating mostly plant, and because that's all they had available to them. And then they had sense of community and, and they had sense of purpose. And you mentioned purpose earlier, I think that is so critical. You have to have a reason for living, right? You have to have why, as long as you have why, and sense of purpose, no matter what challenges are in front of you, you can overcome them. And that's how powerful human beings are. And if you decide to just give up, that is a failure. And no matter how many mistakes you make, how many, you know, failures and debt that you face, as long as you stand back up, and then continue to, you know, pursue your purpose and your why I think Most people will be very, very happy.Ken Brown  Yeah, I think that you saying that you came at 11 years old, you started your journey, probably not the easiest time in your life.Dr. Won  Not at all, I didn't know how to speak English. And but all our family, you know, including my parents, we worked as a janitors, you know, don't want to get my parents in trouble. But when we're 12,13,14 years old, we used to go help our parents, you know, clean the toilets in the building and then I still pass by one of the buildings we used to clean when I was 14 years old. And and that's what we did as a family. And then they, you know, open to the flea market store. My mother was shot at, you know, twice when she was working at the flea market store when she was being robbed. Right. And luckily, they missed, thank goodness and then where my parents lived after I left for college. There was a drive by shooting at my parents house. They got the wrong House, it was supposed to be the next door. But my parents were asleep. And then fortunately, their windows were shattered. And so, you know, we grew up very humble. And a lot of people think that, you know, you're a doctor, you must have come from a doctor family. That wasn't the case at all. And we live in the government assisted housing. But, you know, our parents always gave us you know, good foundation, and always, you know, taught us to have purpose in life. And that really, you know, sunk in with us for you know, since we were little child Yeah, and, and in always the life force, you know, living the life with purpose, and, and that was our mission.Ken Brown  So, you come over here you go through this kind of hardship. Now, we kind of tongue in cheek, talked about how I hope you're as smart as Eric obviously Eric's a very smart guy. He's my crna and he's he could he's still continues to do whatever he wants to do he has entrepreneurial spirit very, very like minded like us. He's very big into purpose into raising his kids the right way and all that stuff. But your your academic background is super impressive. I mean, you know, just for the average person that says, Oh, that's a doctor. Now there's levels of doctor, there's levels of med schools, you gotta really work to get into some of these places. And I, I'm just so impressed that you basically have to put your career that you were worked so hard to do, and you went awesome. I'm gonna work on this now. I love that. I think that is the coolest thing. And I'm learning for you. So I want to ask you a couple quick questions. Dr. Won  Yes.Ken Brown  Because these are the arguments that I get. So the community that I'm in I'm in fact, I should. We'll we'll talk afterwards, but I've been part of some really cool entrepreneurial groups, where it's just like minded people that all they do is sit around and say don't step on this land mine. I blew off my left, you know, theoretically, in a business sense, I blew up my left foot doing that I wouldn't do that, try this software instead try this thing and you know, you read books and stuff like that. Well, a lot of these people are the Paleo community, and they're really smart people, Chris kresser, Rob Wolf, you know, become friends with them in these groups. And what what I'm hearing is, is that in Kevin Wilson, my doctor is not plant based. He's very big into paleo and all these other things. So a couple curveballs towards you. Dr. Won  Sure. Ken Brown  All right. Let's talk about the thing that I get asked a whole lot. Lectins. So you said Dr. Beans do this, what's your thought on lectins? Do they create and then that's going to lead us into the microbiome and and eventually into your entrepreneurial spirit where you continue to grow? So that's where I want to head with this. But can we talk about lectins real quick?Dr. Won  Yeah, absolutely. I think that's a you know, very interesting topic. And so if you think about the Lectin especially in the beans, no one can eat them being raw. You don't eat dry beans, you can eat it, you can't digest it, and we don't recommend it. Right? Because if you eat it, you're going to get nauseated, you're probably gonna throw up. However, if you cook them properly, right, all the lectins are gone, right? And so lectins are there so that the plants can protect itself and so a little bit it's actually healthy for you because you're stressing your body. However once you cook them... Ken Brown  Hormesis.Dr. Won  Yes, absolutely right.Ken Brown  The term Hormesis means that you stress your body a little bit so it adapts.Dr. Won  YesKen Brown  That's why we exercise that's why we fast that's why we do things.Dr. Won  That's why you know, we get exposed to heat that's why we take cold showers right? Ken Brown  I don't take cold showers. I refuse to go that route. I'll sit in a sauna but I will not do a cold shower.Dr. Won  You should try it you know maybe 10 seconds first and you know 15 seconds in the beginning you hate it. But you'll learn to love it. But the lectins...Dr. Won  We're gonna get to elections really quick. Just Just this reminds me my late father in law passed away a few years ago, we were watching a show on navy seals. And a Navy SEAL actually did a obstacle course, where he first soaked himself in warm water, and then did the course. And then they put him in ice water. And then within a sofigel probe, they show that he dropped his core temperature and then through various Navy SEAL techniques, he raised his core temperature. And so my father in law, this is on Christmas, this is about 10 years ago, goes you know, it's Dallas, it's not that cold, but it's cold enough. It's It was like 30 or 40 or something. He goes, I bet you can't even get in that pool. I went out there with my son and my father in law and I jumped in and like a total weenie jumped out in about 10 seconds. So the whole cold thing I think that's funny, but all right, that's the whole point is is that lectins can do this. Let's get back to lectinsDr. Won  Yeah, so but once you actually properly cooked the meals, yeah, I recommend soaking them at least for eight hours or even 24 hours.Ken Brown  Soaking the beans first?Dr. Won  Yes, soak the beans minimum of eight hours. If you have a pressure cooker you don't need to soak them you just dump it in there and you cook itKen Brown  Do can beans qualify?Dr. Won  The can beans are already cooked so you don't even need to cook it you can just open it and start eating them.Ken Brown  Do you find can beings unhealthy or do you always do whole food? Dr. Won  At the house we have both dry beans and canned beans because to make it a little bit more convenient, right. And the can beans are, the studies have shown that they still retain just as much nutrients. And so when I'm really busy, I would open up a can can beans with the my whole grains and mix them up along with different kinds of spices and then along with different greens, but once you cook the bean most of the lectins are gone. So there's really nothing to worry about. And so you don't need to take Lectin you know, supplements or anything like that. If you properly cook the food, then there's really no issues with lectin and if you think about it, so beans are the most known for lectins right? Every single one of the cities, right? There's one common theme among Blue Zones, five cities that has the most amount of centenarians, right? The research by Dan Buettner from National Geographics every single one of them that the common theme was Beans, beans, beans, beans Ken Brown  Shut up! Really? Dr. Won  Every single one of them there was their main source of protein was their beans.Ken Brown  Dang. And I've actually been avoiding them because I'm trying to you know, I've just kind of go with the no grain thing.Dr. Won  Yeah, so the beans is one of the healthiest thing one can consume. Not only it's a great source of protein, but also it's also has so many fodder nutrients. And I consider them as a superfood really, really cheap. Super food, Ken Brown  What are your favorite beans? Dr. Won  All of them, but we have at the house about 10 different kinds of beans. And then when I make grains I usually mix like black beans, pinto beans, white beans, navy beans, kidney beans, along with let's say buckwheat brown rice, wild black rice, barley, mix them up, and then that's how I make the rice and so rice and beans. I don't you know we definitely avoid any refined grains such as white rice,Ken Brown  Oh you do? Dr. Won  Yeah, I we avoid any kind of white anything that's white right?Ken Brown  Okay, so I hope that helped my wife is listening my wife's Puerto Rican. Dr. Won  Uh huh. Ken Brown  So i mean...beans and rice. Yeah, it's just pretty much it's whatever. I'm like, Honey, what are we having? She's like salmon, and beans and rice.Dr. Won  Yeah. That's good. And you just got to put in some greens.Ken Brown  But but but but you avoid the white rice Dr. Won  White rice. Yeah. So the...Ken Brown  As a Korean you still avoid white rice because we love I mean, that's actually our favorite. If we're going to globalize our cuisine for my family, I got a 15 year old a 13 year old and we essentially eat Japanese in this order. Japanese, Thai, Vietnamese, Chinese almost anytime we get a chance to eat out.Dr. Won  You're inner asian. Ken Brown  I'm we are definitely Yeah, it's a it is it is definitely our favorite cuisine. So we end up eating a lot of rice. Dr. Won  Yeah. So interesting fact is that the, the in Asia, you know, while back the white rice was you know, it's extra process right? So this was actually for aristocrats or the wealthy individuals, all the poor people ate brown rice, which is less processed it's unprocessed. Right? And so the the poor people actually live longer they were healthier than rich people, right? Same thing happened 100 years ago, the rich people ate white bread, right? And then the the poor people ate the whole grain bread. And guess what it was a poor people who are healthier, right? So you know, grains, especially white grains, they're extra processed. And so and also raises your blood sugar level much, much faster and raise you know, increases more insulin production or release of insulin. So we try to avoid anything that's processed. So including the the grains. So if you eat you know, brown rice or you know buckwheat barley, black white rice those are the grains that I would recommend that I say it's whole grains not grains, whole grains, Dr. Won  Whole grains?Dr. Won  whole grain.Ken Brown  Beans, beans, okay lectins get destroyed when they get soaked and then followed by cooking and or canned. Dr. Won  Yes. Ken Brown  And then...Dr. Won  Because canned beans are cooked. Ken Brown  Can can beans are cooked and as far as the grains, so yeah, the This works really well for you. And I know right now that there's, you know what I've seen with diets, especially when people make a living like if they have a book or so I mean, I hung out with Rob wolf, the guy looks amazing. He's been keto for 10 years. And Chris kresser is essentially you know, straight up paleo and, you know, I know his blood work is amazing. We've talked about that. And so there are, you know, the the things that actually work it's not working for me. My doctor just told me that's why I'm like, Oh, yeah, we need to we need to call Doug, I need to I need I need to eat his brain and figure out what's going on here because maybe my genetics, so you use the term epigenetics a little while ago. Explain what epigenetics actually is, because there's some confusion around this.Dr. Won  Yeah. So just to simply put it way I like to explain it is our gene is like a light switch. Right? So we are born with certain genes, unfortunately, for some people, and they may have a greater risk of developing certain type of disease. But just because you carry the gene does not actually mean you're actually going to develop those disease. But there's a lot of external factors, environmental factors, including the cancers, right. And so by a proper nutrition and lifestyle, you actually have the ability to turn the genes on or turn them off. So what that tells us is that you actually have a full control. So you know, like Elizabeth Blackburn who won a Nobel prize from UT Southwestern for discovering telomeres did a study with the Ken Brown  She's the one that discovered telomere races?Dr. Won  Yeah. So along with the telomeres, and that's what she, she won the Nobel Prize,Ken Brown  Did not know that wow, out of here, out of here in DallasDr. Won  Yeah at UT Southwestern. Ken Brown  That's, that's impressive.Dr. Won  So she did the research with Dean Ornish, and they got group of patients who had early stage prostate cancer. And then when they did the genetic study, all the over 500 cancer genes were actually turned on. And then they spent three months changing their diet and lifestyle. And then they did the the genetic study again, all the genes were actually cancer genes were turned off over 550 cancer genes, Uncle genes are turned off. So you only took them three months o so especially prostate cancer, right? Especially if you catch them early stage, you really want to treat them with diet and lifestyle change. They said the the traditional surgery, whether it's a chemo or the surgery does not prolong only one out of 49 people actually live longer after getting traditional, conventional medical treatment.Ken Brown  Well, when you start looking at some of this, I listened to a podcast called medical reversals. It was on Freakonomics, the Freakonomics podcast. And they they actually had some doctors on there. And they and if you look back at all these medical reversals, so basically your doctor says, do this, and then we go, Oh, no, that was wrong, because now we've looked at our cohorts of 10,000 patients over 10 years. We can go on and on about that the estrogen replacement therapy, one of the things that's been brought up and I brought this up to my doctor because my cholesterol is statins and statins have not been shown to improve lifespan. And so the question is, do they actually decrease the incidence of events, but it has not been shown to improve lifespan. So now I start. I'm at that stage in my career in medicine where I'm starting to question so many things. I'm having patients come to me, and well, let's throw this one out with autoimmune disease. And you and I were talking about this I treat a lot of Crohn's disease, ulcerative colitis. I use drugs like Remicade and humera. Have you had any experience with as an orthopedist you're going to be exposed to rheumatoid arthritis, you're going to be exposed to ankylosing spondylitis. Poly arthropathy from these other things. Have you had any wins with using your method?Dr. Won  Absolutely. So some of them are my patients and some of them are attendees to our free seminars. And I gave an example of Denise she gave us a permission to talk about her. And so she came to us suffering from severe rheumatoid arthritis and she's been on multiple medications, even methylstrexate as in the past and humira. And humira costs 25 to $50,000 a year. Right? And one of the side effects is heart failure. And she began to have a severe heart issue. So they had to take her off. And and she she was in severe pain. And so I said, you know, you got nothing to lose. You tried everything else. So why don't you try a whole food plant based nutrition, and that's what she did. She did that. January 1, 2018. Within two months, she was in remission. All the pains were goneKen Brown  On her alright rheumatoid arthritis? Dr. Won  Rheumatoid arthritis. Ken Brown  So rheumatoid arthritis is an autoimmune disease. Autoimmune means you something turns a genetic switch on and your body starts attacking yourself. In gastroenterology, I see it with all sort of colitis, Crohn's disease, celiac disease, autoimmune hepatitis. In your field. You see it with the joints.Dr. Won  With the joints rheumatoid arthritis, but we also I've seen patients with multiple sclerosis, right? And actually, this was another patient who walked in or not walked in, came into the clinic on a wheelchair and had multiple sclerosis. So we actually... Ken Brown  In a wheelchair?Dr. Won  In a wheelchair.Ken Brown  That's very advanced MSDr. Won  It's pretty advanced. And and the patient went whole food plant based, and was six to eight months later, when they came back for a follow up visit. He actually walked out walked in with a cane. So he still had weakness, but it got him off the wheelchair and now he's able to strong enough to actually walk with a cane. Ken Brown  Just diet change? Dr. Won  Just a diet change. And he was off to all the medications and he's not the only one and there's a one lifestyle medicine physician even up in New Jersey, a good friend. She was initially infectious disease doctor and during her residency or fellowship, she woke up one day completely paralyzed. Ken Brown  What? Dr. Won  And that's how she discovered she had multiple sclerosis. And to a point she was walking with a cane and she was bad to get on a wheelchair. And she made the she discovered she read an article about blueberries, right? She said No way. There's no way and this can't be and she starts researching and really realized the autoimmune disease starts from the gut. And she needed to find a way to decrease inflammation. And she needed to once she healed her gut, and she changed her complete, you know, nutrition when whole food plant based. 10 years later, she ran a marathon.Ken Brown  I'm sorry, I don't have any Kleenex. Do you have any Kleenex because I have tears of joy. I just had an orthopedic surgeon say that. Everything starts in the gut. Oh,Dr. Won  Yeah. We think that you know, a lot of the the lifestyle medicine physicians and believe that autoimmune disease may be in a different sort of autoimmune disease, whether it's rheumatoid arthritis, Hashimoto thyroiditis, multiple sclerosis, maybe it disease, it all starts from the gut. And then it manifests to a different disease based on our genetic makeup. And so our treatment method whether it's, you know, lupus, multiple sclerosis, you know, Hashimoto thyroiditis, it's all pretty similar. You know, they may, we may make little bit of a different protocol for them, but overall as a whole food plant based, and many of them improve significantly.Ken Brown  Wow, that is. So we've actually, that's actually a common theme that we talked about, we have brought some people in, but my thing is we've got lots of data to show that when you have an inflammation in your gut, that leads to an inflammatory cascade that can cause this epigenetic phenomenon. And so somebody sitting around listening, so I want to talk about what else you have going on, which means that you've taken it to the next level, but I everything about, about this show and about what we want to do is talk science first. Clearly, you're a brilliant And you know, you're, I'm a, I'm a gut doctor. So you know your s-h-i-t. So I wanted to throw this article out at you because it's fascinating that we can talk disease. And I could sit there and say if you've got rheumatoid arthritis if you got ms if you have anything, but there's also one underlying thing that happens to all of us and you keep talking about the Blue Zones. A recent review article, my little secret weapon will eventually be able to disclose who it is, but she sent me an article yesterday. And with you coming on it is a review article on the new insights for cellular and molecular mechanism of aging and aging related diseases. herbal medicine is a potential therapeutic approach. So in other words, what this title says is, yo we're all aging. And why do you want to load the gun faster than it should be loaded? So what this article looked at is they go into the background A little bit where 900 million people in the world are over the age of 60. Dr. Won  Wow. Ken Brown  And you just pointed out that it doesn't matter where you live now it looks like it's it's pretty much spreading everywhere. So aging, which can be divided into both pathologic and physiologic. So if you are perfectly healthy, you're going to physiologically age if you choose to load your gun faster, that's pathologic aging. And this article gets into really cool geeky science about the complex biological processes and the decline of tissue and origins and structural degeneration and then they go into telomeres and then they go into the fat, a common thing keeps popping up. And it is reactive oxygen species or oxidative stress. Dr. Won  Yes. Ken Brown  So stress at a cellular level, or inflammation at a subtle level leads to aging. Dr. Won  Yes. Ken Brown  So if you didn't care about anything about the fetus having a heart attack or a 10 year old having coronary artery disease, We spend a lot of money trying to look younger. I just got done talking about the other article that said that at age 47, maybe that's when men look in the mirror and go, Oh, I'm I'm there. I don't know. It all comes down to reactive oxygen species. This leads to they can actually get into the actual mechanism. So one of the things I run into that we have discussed, which is I'm sure you've run into because I think your field is a little bit less holistic than gi, which is probably because the gut affects so many things. But I imagine if you're trying to talk to one of your colleagues at a conference and say hey, plant based they probably look at you like what?Dr. Won  Yeah, I'm I don't represent typical look of orthopedic surgeon right? So if you imagine orthopedic surgeon those of you who don't know like in medical school, we are like the cords pedic surgeon smart jocks, right? Everyone's hitting the gym, you know, bone broke me fix. Big guys, ex-thletes, right? And then somehow I snuck in as a nerd, right?Ken Brown  So I have I have a friend who played football for the San Francisco 49 years played at the University of Notre Dame. And we have or he's very good friends with orthopedic surgeon named Brian rhadigan. And he played linebacker for Notre Dame, and if there is ever the avatar of what I thought this guy was just jacked, and you know, and he's an orthopedic surgeon now for Notre Dame. Dr. Won  Wow. Ken Brown  But anyways, yeah, so yeah, you you are talking different than the typical orthopedic surgeon.Dr. Won  Yeah. And so but yeah, but I think even with orthopedics, and also especially in spine, some of our patients, after if they choose to follow our diet and lifestyle modification, they came back even with herniated disc, most of the inflammation was gone, pain was gone, and so they they would cancel the surgery. I said Congratulations, right. And so if I can help patients, that surgery is definitely the last resort.Ken Brown  Say that one more time you got paid to operate and you were happy when you didn't have to operate?Dr. Won  Yeah, absolutely. Because there's plenty of patients who's not following the lifestyle modification and who is in agony, who failed all the conservative treatment, who's going to need the surgery. But you know, what I would love to be able to do is to prove to the medical community that so many of the surgeries and procedures that we do are completely unnecessary, because if people are willing to make the lifestyle modification, if the physicians actually know and teach their patients, how to make the modification, because most of them do not know. Right, then I think, you know, many people can avoid significant surgical procedures, whether it's a cardiac cath open, you know, open heart surgeries, which we know that does not extend anybody's life, right. And same thing with spine surgery. And, you know, orthopedics is a little bit If you break a bone, you broke a bone and you need surgery to fix it right?  Ken Brown  Don't try to hobble into whole foods after that skiing accident.Dr. Won  I don't think that whole foods is  going to fix that broken bone, but it may help you heal faster, but you're probably going to still need surgery. And so that is one of my mission and I get a great enjoyment out of it. And you know, I remember one patient who walked in who had a thoracic herniated disc. And you know, in order to do the surgery, we have to do a thoracotomy. So basically cracking our chest open the compress the lung in order to get to the spine from the front. And I said, you really don't want to have this surgery. We can do it if you want to. However, why don't you give me three months make this changes come back in three months. If it doesn't work, then we'll go ahead and do the surgery. She came back to clinic and three months along with her husband, she lost 40 pounds. He lost 60 pounds, right? And she said her pain was gone. And she said doctor, I don't need your service. anymore awesome congratulations. So I think it is very possible and you know once once you have seen that I just get a kick out of itKen Brown  I'm feeling like a little jerk right now because we did a show on using cell phones while there people around the bathroom doing social media posts and I I told everybody to keep doing that because it creates hemorrhoids so they can come see me. I feel like a jerk. I'm over there encouraging, sit on the toilet longer and make an appointment with me.Dr. Won  That's funny.Ken Brown  Oh, you're making me look bad man. I want to talk about something about this article because I we use the term reactive oxygen species all the time. Now one of the things that they got deep into this article is about a lot of the end origin disease that kills most of us. cardiac disease strokes. dementia. A lot of it comes down to blood vessels. Yes, the endotheliam meaning that as our blood vessels, all this inflammation leads to endothelial dysfunction, and impaired activity and arterial stiffness. And the reason why I bring this up is because I'll plug this the polyphenols and Atrantil we do know that they actually improve the most polyphenols when taken in. There's literature for this. But when we first launched Atrantil we did it strictly for people that bloated and then we had all these people that kept staying on it. And that's when I started backing up because I was looking at one little problem then went, Oh, this is actually it's sad that it's that I'm now learning because all I've been doing is doing plant based, but I started with a pill and now I'm working my way to lifestyle. Yeah, which you're doing lifestyle. And you realized, Hey, I can help people in different ways. So you noticed immediately that endothelium is really important. And when we talked before and you brought me some gifts, I would like to talk about what else you have going on here because very clearly, you have put some serious thought into this. And then I came backwards. I started with a plant based product to treat something and now I'm learning about a plant based lifestyle. Yeah, you did the opposite. You started plant based lifestyle and said, I'm going to produce the best product for that. Yeah. So tell me what you got here.Dr. Won  Yeah, so one of the things that we developed was, is called Neo Nox is a nitric oxide booster,Ken Brown  Neo NoxDr. Won  neo neo, no x, no x, and this product was developed without intention of developing a supplement company. what we realized was as I was doing research, even as a physician, we knew that heart disease was a number one killer, but I didn't realize how severe it was. It is actually the number one killer of both men and women worldwide. Right? And, you know,Ken Brown  Yeah we start seeing once women go into menopause. Yeah, they get the same risk as men.Dr. Won  Yeah, exactly. And, and so and a lot of women just getting neglected and they think it's a man's disease. And but women develop a cardiovascular disease just as much as the guys and, and one in three deaths in us is related to vascular disease. So pretty significant amount. And it all comes down to endotheliam and nitric oxide, what I realized was the most important molecule in our body because it saves endotheliam, and is produced it within our endotheliam. However, as we age, by the time you're 40, you lose about 50% of your ability to produce it. By the time you're 60 you lose about 85% of your ability to produce nitric oxideKen Brown  Say that one more time.Dr. Won  So by the time you're 40, you lose about 50% of your ability to produce nitric oxide, which is the most important molecule in our body.Ken Brown  Why do why do we do that? Dr. Won  So a few things number one is produced in your endotheliam. Right intercellular is basically the inner lining of your artery. And so, as we age, we develop atherosclerosis, we damage the endotheliam. So therefore, we lose the ability to produce the, the nitric oxide, but along with that... Ken Brown  So the inflammatory process damaging the endotheliam does not allow us to produce the one molecule to repair the endotheliam.Dr. Won  Exactly. And so and not only the nitric oxide, is that the strongest vasodilator that lowers of blood pressure, and then also vasodilate the vessels so they're more nutrients and oxygen can be delivered to the end organs, right. It also stimulates the stem cells and activates the stem cells and mobilizes the stem cells, Ken Brown  nitric oxide does? Dr. Won  Nitric oxide, and that's how we really actually got into the nitric oxide because we knew we needed to boost the nitric oxide to our patient when we're doing orthopedic stem cell therapy, right to to help them prevent either You know rotator cuff tendonitis and tear surgeries Ken Brown  We had we had weighed with 10 on our show the orthopedist. Dr. Won  Yeah. Ken Brown  From Fort Worth that had the the Panama stem cell clinic.Dr. Won  Yes. Yeah. Ken Brown  We deep dived into stem cells. That's some cool stuff. Yeah.Dr. Won  And but, but most people are looking for that magic pill. They want the injections, right? And the stem cell therapy, but you need to activate them and people who needed the most are typically 60 Plus, right, sometimes 40 Plus, but most of the patients we have arthritis are 60 Plus, but they can't really activate their stem cells because they don't have any nitric oxide. That's part of the reason why people develop cardiovascular disease. people develop diabetes, right? people develop erectile dysfunction, which is a vascular disease. Right. And so that's, that's why the even Biograph Cialis only works on 50% of the population.Ken Brown  So one of the reasons why game changers has been so much more well received is that they have a whole segment on nighttime boners Yeah. And how eating a plant based diet actually improves erectile dysfunction. Dr. Won  Yes. Ken Brown  And so and not just erectile dysfunction actually improves nocturnal erections I should say. Yeah, boner seems a little bit unprofessional. Dr. Won  You are a doctor.Ken Brown  But um, yeah. So that's, that's one of the things so it's, it's when you talk anti aging or you talk sexual performance, that's what people spend all their money. Yes. They don't sit there and go, Oh, I'm going to have a heart attack. Yeah, when really, it's all the same process. It's all the same thing. The thing that's making you look older, the thing that's making you not perform as well in bed is the exact same that's going to kill you! Dr. Won  Exactly. And, and, you know, the dementia, which are mostly now we're realizing that is a vascular disease also, because you're just not getting enough blood to your brain, right. And so, and also lack of energy, you know, after age 40, everyone's fatigue suffering from fatigue, lack of energy, because  mitochondrial biogenesis is actually initiated by nitric oxide also. So it helps nitric oxide stimulates the production of mitochondria, which is the energy source. Ken Brown  There we go. Yeah, so that's the that's the energy source of every cell. Every cell has a little power plant. Yes, it's called the mito

A large study published in the 1970s shaped how most people have thought about normal cholesterol levels for over 40 years . nOw it is estimated that nearly 50% of people over the age of 65 take statins and this is set to increase . Statins are good at lowering cholesterol BUT COME WITH SIDE EFFECTS. Coupled with the fact that – lowing your level of cholesterol does not seem to impact the incidence of heart disease . this was found in a BMJ study in 2016. What is cholesterol ? It is best described as a fat like waxy substance which can be found in all cells of the body including the brain . It actually plays an important role in - Brain neurotransmitter creation - Vitamin D production - All steroid hormones - Production of bile salts that aid digestion Cholesterol levels are important because high cholesterol levels build up in your arteries, forming plaques that lead to arteriosclerosis, a form of the heart disease. But the key thing to note id the ratios between HDL CHOLESTEROL – Good And LDL cholesterol – Which is often termed “bad cholesterol “ Usually thy LDL must be kept in a particular ratio in relation to HDL . Another type of cholesterol not usually mentioned is the VLDL – very low density lipoprotein- This is what transports most of the Triglycerides in the body which is what is actually for the build up of plaques in the arteries Cholesterol levels Simple facts 1- Keep HDL levels above 50 MG/DL (1.3MMOL/L) 2- LDL Keep LDL below – 130mg/dl (3.3mmol/l 3- Keep your HDL :LDL ratio at 1:3 So how do you maintain optimal cholesterol levels 1- Cut Carbs Although it is widely stated that reducing fat intake is key , it is actually noted that cutting carbs will help reduce LDL 2- Lose Weight Losing just 5–10 percent of your total body weight helps to reduce triglycerides and increase HDL levels. 3- . Stop Smoking Smoking tends to lower your HDL levels while raising LDL cholesterol, making it an unacceptable risk to take if you’re at risk of heart disease. 4- Exercise medium-intensity resistance exercise or high-intensity aerobic exercise increases your HDL levels- The other 2 ways are - Using Supplments like Niacin and taking cholesterol lowering drugs like Statins References 1- Mann S, Beedie C, Jimenez A. Differential effects of aerobic exercise, resistance training and combined exercise modalities on cholesterol and the lipid profile: review, synthesis and recommendations. Sports Med. 2014;44(2):211–221. doi:10.1007/s40279-013-0110-5 2- https://www.ncbi.nlm.nih.gov/pubmed/9130034 3- -https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652281/ 4- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836695/

Serena leads a nutritional intervention that investigates the effect of the nutrient choline on blood health markers (triglycerides, HDL/LDL cholesterol, glucose, inflammatory markers). Egg intervention in healthy adults has shown counter-stereotypical results—a decrease in LDL cholesterol, blood triglycerides, and blood sugar. Serena examines how this intervention affects a population with metabolic syndrome, a condition characterized […]

น้ำมันมะพร้าว น้ำมันเพื่อสุขภาพ ? หือออ จะใช่เหรอ น้ำมันหมู กินกันมาตั้งแต่ปู่ย่าตาทวด ดีกว่าน้ำมันพืช ? อีกแล้วเหรอ ตรวจสุขภาพประจำปี ความดันสูง คอเรสเตอรอลสูง ไตรกลีเซอไรด์ HDL LDL โน่นนี่นั่น บอกอะไรได้บ้าง . มาทำความเข้าใจ "ไขมัน" ศัตรูที่รักของหลายๆคน ไขมัน-อาหาร-ร่างกาย-สุขภาพ-ความเชื่อ อยากจะดูแลสุขภาพต้องฟัง จะทำอาหารให้คนที่รักกิน ยิ่งต้องฟัง

Do you know your Cholesterol, HDL, LDL, and Triglyceride Levels? --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/drnikkifnp-bc/support

00:50 – Introducing today’s inaugural AMA episode01:03 – Dr. Stephanie introduces her co-host for today’s episode, Stephanie Major06:19 – Differentiating between time restrictive eating and fasting12:16 – Benefits of fasting13:28 – Timing your post-workout meal16:23 – Breaking down PCOS, polycystic ovarian syndrome18:39 – The important role that hormones play20:03 – Fasting with PCOS21:49 – Why Dr. Stephanie never does an extended fast in the week leading up to her period26:20 – The incredible differences in a woman’s biology28:16 – Dr. Stephanie speaks to some recent studies on rodent fasting32:27 – HPA Access Dysfunction35:32 – How fasting can affect thyroid issues, including Hashimoto’s Disease40:47 – Fasting and hair loss41:54 – The three stages of hair growth43:29 – Supplements to combat hair loss during fasting44:34 – Best practices for preparing for an extended fast49:10 – Signs and signals that indicate you should end an extended fast52:05 – Breaking a fast54:30 – Dr. Stephanie discusses fasting while travelling57:44 – When Dr. Stephanie does longer fasts58:41 – How to explain fasting to your children1:04:19 – Who should not be fasting1:05:37 – Dr. Stephanie announces another upcoming AMA episode1:07:01 – Where listeners can follow Dr. Stephanie and subscribe to her newsletterTWEETABLE QUOTES“When you allow for the stomach to fully empty, you will have a better quality sleep.” (09:42)“When she does eat her next meal, it should have protein in it, and a minimum of twenty grams. So, a minimum of twenty grams of good, quality protein to be able to drive that muscle protein synthesis from her diet.” (16:07)“Around Day 21 is when we start to see progesterone rising. Progesterone is a potent stimulator of your appetite. It slows down your bowels. And it can also affect your mood and it drives cravings.” (23:05)“When you are obese, male or female, the data is clear in terms of fasting and the benefits that it’s going to impart to you. So, if you are overweight, if you have excess adiposity fasting is probably the most powerful weight-loss tool on the planet.” (31:28)“That’s why I always say females are the original biohackers. We will do anything to feel better.” (35:24)“When you start fasting, it is a temporary change you may notice like clumps of hair falling out, but it tends to return somewhere between three to six months. You’ll notice that that falling out stops.” (41:40)“When you’re thinking about what breaks a fast, you have to be thinking about what your goal is surrounding the fast.” (52:32)LINKS MENTIONEDBetter! WebsiteDr. Stephanie’s WebsiteDr. Stephanie’s Twitter – @dr_stephanieDr. Stephanie’s Instagram – @dr.stephanie.estimaDr. Stephanie on LinkedInDr. Stephanie’s Twelve Step Guide to FastingRELEVANT STUDIES, COMMENTARY, AND RANDOM BITS FROM MY PREP NOTESTime Restrictive Eating (TRE) vs. FASTINGTRE - is restricting the hours in which you consume calories. This is where I start most people off if they have never heard of the concept of fasting, or they are intimidated by it.So very basic would be a TRE of 12 hours – 12 hours of fasting, 12 hours of eating starting at 7am - 7pm.I would quickly move this to a tighter eating window of 8-9 hours as the baseline for how you eat all the time. If one were so inclined, and if you’re listening to this podcast, I would also add in the caveat of making your last meal 3 hours before your bedtime. This allows the stomach to fully empty, and for our central and peripheral clock to sync up.SCN is your central clock. It detects light coming in from the back of the retina and is the sleep-wake cycle master regulator.However, we have other clocks in our bodies: the liver, pancreas, and kidneys, for example. The liver in particular senses intake of food.If you have a late meal, there is a sort of homeostatic dissonance where the brain is saying ‘less light, time for bed,’ but the liver is saying, ‘but we just got a huge bolus of energy!’ This will affect sleeping quality and quantity. It is hard to sleep well on a full stomach.If you listen to Sachin Panda, he will say anything with a caloric value will start the clock. So, in the strictest sense, the 5 calorie pre workout drink would start the clock. As far as I am aware, Mg does not have a caloric value, and neither does L-theanine.FASTING is for 24 hours or more and there’s a myriad of ways to do it: Water only, NC LF, or CR.Benefits are similar and, like anything, has a bell shaped curve:drops in insulinactivation of sirtuinsAutophagy - cellular cleaning up of debrisBDNFimprove lipid profiles ( HDL: LDL ratio, TG levels)allow for rest and repair of gutFFA & ketone production / alternative substratemental clarity and focusamps up GHchanges in gene expression upping longevity / FOXOcardioprotective benefitsPowerful weight loss toolOn Refeeding Within 15-30 Minutes Of Exercise:There has been considerable work undertaken to determine the optimal timing of nutritional intake in order to maximize post-exercise MPS and ensuing adaptations to training (Cribb & Hayes, 2006; Hoffman et al. 2009). In general, it is largely irrelevant whether the feed is given pre-, during or post-exercise. This is because the delaying of the muscle-full response appears to last at least 24 hours (Burd et al. 2011) after a single bout of exercise, which may help explain adaptations likehypertrophy/remodelling of muscle over time, which is independent of proximity-dependent feeding patterns.Types of Exercise:Endurance-type exercise such as running or cycling is associated with increased synthesis of mixed muscle proteins. However, these acute responses are not associated with significant changes in muscle mass (i.e. hypertrophy observed with resistance exercise).The same individuals performed a 10-week resistance (weight-lifting) programm in one leg and a 10-week endurance (cycling) programm in the other. After training, post-exercise myofibrillar not mitochondrial protein synthesis increased with resistance exercise (Wilkinson et al. 2008). Conversely, after training mitochondrial protein synthesis increased only in the endurance-trained leg, whereas myofibrillar did not. These data seem to suggest a ‘matching’ between MPS responses and phenotypic changes, i.e. muscle hypertrophy in resistance training versus mitochondrial biogenesis in endurance training.I have a general disdain for traditional cardio machines and feel like I am on a hamster wheel. I have retrofitted my outdoor bike with a TacX and use an app called ZWIFT so I can have some sort of indoor cardio in the winter months. I love to climb hills, have a psychological and physical resistance to sprints. I have to pump myself up mentally and physically when I know I’m sprinting, but generally I hate them. If I were to guess, I have way more type 2a mm fibres than 2b, because I despise sprints. It feels like I peter out and need a much longer recovery. This may be due to my years as a step instructor and being an endurance runner.Best practices:Vary workload and intensityAim for at least 20g of good quality protein per meal(this can change as we age, necessitating the need for more protein to continue to stim MPS)A few more studies should one want to read up further:No effect on protein supplement timing:https://www.ncbi.nlm.nih.gov/pubmed/19478342/24h window for refeed:https://www.ncbi.nlm.nih.gov/pubmed/21289204/20g for MPS:https://www.ncbi.nlm.nih.gov/pubmed/19056590/PCOS & Fasting:Insulin levels elevated:inverse relationship to SHBG (high insulin, low SHBG, more free T)direct relationship with LH (high insulin, higher LH, lower relative surge before ov)Insulin is a nutrient sensor. You eat carbohydrates or proteins, and insulin goes up. This signals to the body that there is sufficient food to drive growth. (There are other nutrient sensors involved - mTOR and sirtuins, but let’s stick right now to insulin and its role in PCOS)High insulin levels drives growth. For women of reproductive age, the ovaries are the queen of cells. They have 100-600K mitochondria in them, and are the most rapidly growing cells in the body.The other issue excess insulin has on a reproductive female is is drives up LH. LH levels should only surge right before ovulation, to help the mature follicle release the viable egg. If LH levels are higher throughout your cycle, the egg cannot be released. I always liken LH to that uncle that comes over for dinner, slaps you on the back so hard to make you spit out your food. That is basically what LH is doing to your follicle.Insulin has an inverse relationship the shbg. Shbg will, like its name suggests, bind sex hormones, like testosterone. Sex steroids and thyroxine are shbg regulators, but so is insulin. More insulin, less shbg, meaning more testosterone is free and able to exhibit its masculinizing effects.So when we are fasting, we are not stimulating insulin to rise, and therefore will see a lowering of LH throughout the cycle, and an increase in shbg, which will lower free T.With PCOS patients, fasting is a powerful tool to help regulate this hormonal derangement. At the very least, depending on the severity of symptoms and the patient’s goals, a TRE of 8 hours. I would also be strongly inclined to throw in several OMADS, and potentially a monthly or quarterly long fast in there as well if there was excess adiposity.I would also be looking at other lifestyle changes, like weight lifting with a focus to increasing lean mm to assist in further insulin regulation and glucose disposal.On Females & Fasting:Fasting for women is different for men and women. We do see some gender specific differences. For obesity, whether male or female, the benefits are largely ubiquitous. It is when you get closer to normal BMIs that the data begins to differ. Some rodent studies have demonstrated deleterious effects on females and either alternate day fasting or prolonged CR.Malesimproved insulin sensitivitywaking and sleep patterns were uninterrupted,they were more fertile (gonadal transcription factors),Improved lipid profileFemale rats ‘masculinize’ - meaning their ovaries shrunk,With 20 CR:irregular cycling patternsWith 40% CR:they ceased ovulation and menstruating altogetherbecame hyper alert,learning and memory went up,sleep patterns were disrupted,heightened stress response,Upregulated BDNFIncreased adrenal sizeIn human femalesADF showed poor glucose tolerance and no change in insulin sensitivity in non-obese womendid not see this negative effect with men, and only the men showed improvement in TG levelsSo what do we as women do?So if you are overweight, fasting is going to be a good option for you to reduce adiposity, and to help regulate metabolic hormones. Most of the studies I have looked at that detail fasting interventions report positive outcomes in cardio metabolic parameters.It is when we trench into waters of hormonal issues, and also fasting with women who are not obese, where things can get murky. Even women with the same condition are going to be different. You are not the same hormonal each day of your cycle. We are just extra like that.Must consider:HPA Axis Dysfunctionchronic low grade stress (physical, chemical, emotional)pro -inflammatory - pro cytokineslong term fasting is a stress, and may contribute to the allostatic loadshort term fasting like TRE is appropriatemost women have some sort of HPA derangement until proven otherwisepregnant, delivered a child, sleepless nights associated with kids, and then if you work...good luckPCOSin this condition, our bodies behave more malefasting, especially longer term fasting on a monthly or quarterly basis is greatallows for the drop in insulin, and can lend to better T regulationFor women like myself who are not obese, do not have hormonal issues, what do we do?The truth is the jury is completely out, and we do not have enough literature to really tell us either way. I think there are measurements you can watch: ketone levels, glucose levels, and subjective observations that can help you monitor your fast. But, I would definitely seek counsel in a trusted primary care physician so you can be monitored while doing it.I personally TRE everyday - it is around 4-5 hour eating window when I eat. While I love eating, I find it incredibly distracting and annoying to getting into my work, so I will have a large meal around 11am, and then a snack with the kids when they get home. Usually no dinner.For women of reproductive age, there is no wrong time to fast, but there are decidedly easier and more difficult timesAgain, talking in depth about gaming your menstrual cycle for metabolic and body comp gains soon, but the first week of your period - when P and E are low is much easier than the week leading up to the bleed.Reproductive Function in Response To Fastinghttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0002398https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0004146Alternate Day Fasting in Humanshttps://www.ncbi.nlm.nih.gov/pubmed/15833943?dopt=Abstracthttps://academic.oup.com/ajcn/article/81/1/69/4607679Sex Differenceshttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200169/?tool=pubmedhttps://academic.oup.com/ajcn/article/85/4/981/4648934Obese Females & Fastinghttps://www.ncbi.nlm.nih.gov/pubmed/23171320https://www.ncbi.nlm.nih.gov/pubmed/29534545On Autoimmunity & Fastinghttps://www.ncbi.nlm.nih.gov/pubmed/27239035On Fasting & Hair Loss3 Distinct Phases of Hair GrowthAnagen Phase is the active growth phase. It lasts anywhere from 2-6 years and is largely genetic in terms what your window is. It could be up to 1 cm every 28 days.Catagen Phase - follows the anagen growth phasetransitional stage where growth stops, somewhere around 2-3 weeksfollicle stops producing fiberTelogen Phaseresting phaseWhen the body is subjected to extreme stress, as much as 70 percent of hair can prematurely enter the telogen phase and begin to fall, causing a noticeable loss of hair3 months in lengthReasons for Hair LossIt’s not the fasting per se, but the large, sudden change in calories. The body repurposes energy for vital function (brain > hair). It can also be caused by vitamin & mineral deficiency. Zinc has been shown to be a cause of hair thinning. As you use up glycogen stores, your kidneys excrete excess water, Na, zinc, Mg, K.Hair loss can also be affected by the supplement or foods once you resume eating (ex. beef, lamb, chicken, mushrooms). It can be caused by not getting enough protein in your diet (aim for 20-30g good quality protein per meal). When you do start eating again, making sure you are getting adequate biotin, which is known to increase hair thickness.Foods with biotineggs w yolkavocadoessalmonspinachMSM - methylsufonylmethane - forms the structural links in things like skin, hair, and nails and strengthens cartilage and tissuefound in animals & animal proteinsCollagen - (from bone broth or supplementation)Lack of collagen has been linked to early hair loss, hair thinning, hair graying, and spine degeneration.ENJOYING THE SHOW, READY FOR MORE?Please Subscribe to Better! With Dr. StephanieJoin our Private Facebook Community for Better!Rate and Review: Show your support and help spread the word by writing a review, along with a 5-star rating on Apple Podcasts: https://bettershow.co/apple

The concept of “good” & “bad” cholesterol is outdated. Yet, most docs are still focused on HDL & LDL as an indicative picture of our cardiac health. Unfortunately, they are behind on the most up to date research. In this episode I explain the role of cholesterol in the body, why our cardiac health is more complicated than just HDL & LDL, what numbers your doctor should be checking in addition, and of course what foods will help you instead of contributing to the problem.   CHECK OUT drlaramay.com/lightbodyradio/cholesterol for all the resources and literature you can reference to learn more.

น้ำมันมะพร้าว น้ำมันเพื่อสุขภาพ ? หือออ จะใช่เหรอ น้ำมันหมู กินกันมาตั้งแต่ปู่ย่าตาทวด ดีกว่าน้ำมันพืช ? อีกแล้วเหรอ ตรวจสุขภาพประจำปี ความดันสูง คอเรสเตอรอลสูง ไตรกลีเซอไรด์ HDL LDL โน่นนี่นั่น บอกอะไรได้บ้าง . มาทำความเข้าใจ "ไขมัน" ศัตรูที่รักของหลายๆคน ไขมัน-อาหาร-ร่างกาย-สุขภาพ-ความเชื่อ อยากจะดูแลสุขภาพต้องฟัง จะทำอาหารให้คนที่รักกิน ยิ่งต้องฟัง

HDL-LDL Cholesterol Misconception For access to blog, video, article, shareable quotes: advancednaturopathic.com/hdl-ldl-cholesterol-misconception/ Get Dr. Roberts’ new book: http://advancednaturopathic.com/building-a-healthy-child/ Join Us on Facebook: https://www.facebook.com/AdvancedNaturopathic/ Follow Us on Twitter: https://twitter.com/drmelinaroberts -------------------- ABOUT DR. MELINA ROBERTS ------------------- Dr. Melina Roberts is a Naturopathic Doctor, Author of Building a Healthy Child, Founder and Clinic Director of Advanced Naturopathic Medical Centre in Calgary. She is a leading authority in the field of naturopathic medicine specializing in European Biological Medicine effectively treating digestive issues, chronic disease and cancer. ------------------- ABOUT ADVANCED NATUROPATHIC MEDICAL CENTRE ------------------- Advanced Naturopathic Medical Centre is Canada’s Comprehensive Centre for Biological Medicine. We are a patient-focused, professional medical practice that utilizes advanced, comprehensive testing and therapies to help people of all ages and all levels of health to be able to reach their optimal health. Visit our website: advancednaturopathic.com ------------------ SUBSCRIBE ------------------ Never miss a video and join our YouTube community: https://www.youtube.com/user/drmelinaroberts

Today if you look around everyone is taking selfies to show off how they look, but actually only a select few of us are looking inside, trying to understand what is happening inside our most important machine. - Dr. Gil Blander With a huge focus right now across the world on diet and exercise, and with all the New Year's resolutions fading fast, how can we actually quantify and track our progress to know if the inspired health and wellness actions we're taking are truly making a difference? We explore this in Wellness Force Radio 158 with Chief Scientific Officer of InsideTracker, Dr. Gil Blander, and dive deep to uncover the truth about the exciting and rapidly emerging field of biomarkers and blood testing, and how they correlate with genetics and epigenetics to give you the inside track on upleveling your human optimization. Discover how taking a simple blood test can give you an accurate blood biomarker analysis plus personalized interventions for nutrition, exercise, lifestyle and supplements to optimize health and fitness. Save 15% On Your Biomarker Test - Use Code "wellnessforce" The team at InsideTracker has gifted the Wellness Force Community with 15% off your 2018 biomarker test kits and services. This is huge for us, as there is no greater indicator about your health and wellness than looking inside the window of your own unique biomarkers. Click here to sign up and get your WFR discount. Listen To Episode 158 As Dr. Gil Blander Uncovers: The meaning of "What if you could take a selfie from the inside?” How InsideTracker supports ourglobal collective's progress for human optimization For Men: What are the ED-related biomarkers men should track For Women: What specific blood tests can women take compared to men What are the 3-5 most pivotal biomarkers to judge a healthy body How taking a full spectrum biomarker test actually help someone noticeably improve their health and wellness How are biomarkers different from genetics Why are biomarkers dynamic and modulated by simple interventions such as diet, supplementation, exercise, and lifestyle changes What can we learn from epigenetics that apply to long term behavior changes that we can make in our lives The real ranges of cholesterol (HDL/LDL) we get to shoot for What are the optimal Vitamin D levels Dietary changes can we make from a blood test How Dr. Gil Blander sees using uBiome, Voime, and other gut tests in combination with blood tests The scientific approach for actionable health behaviors when looking at a tool like 23&Me Understanding CRISPR: What people need to know about this powerful science Links From Today's Show Wellness Force Radio Discount: Click here to sign up and get your 15% off your biomarker test! Dr. Gil Blander on LinkedIn  Inside Tracker on Facebook Inside Tracker on Instagram  Inside Tracker on Twitter Inside Tracker on YouTube Inside Tracker on the web "Erectile Dysfunction Is Affecting More Men Than Ever. We're Here to Help.” “In Defense of Vitamin D: The Facts You Need To Know” "Food Allergies & Sensitivities: All the Science You Need to Know" The Science: Inside Tracker CRISPR: The future of gene editing  Wellness Force Radio Podcast: Dr. David Perlmutter: The Grain Brain Whole Life Plan "In 2018, We Will CRISPR Human Beings" 23andMe uBiome Promethease Wellness Force Facebook Group Power Quote From Dr. Gil Blander "Today if you look around everyone is taking selfies to show off how they look, but actually only a select few of us are looking inside, trying to understand what is happening inside our most important machine. What we are doing with InsideTracker is allowing you to see what's happening inside your body, and after that we're giving you an actionable recommendation to improve your health, wellness, and performance. This is very similar to what is happening with your car when you plug in a computer. The system tells the ignition exactly what are the issues that the car suffers from today, right now. I see InsideTracker and biomarker testing with recommendations very similar to what's happening with a car. We are checking the machine, finding out what are the issues, and then we intervene. Hopefully, with the right guidance, we improve the quality and longevity of our lives."  - Dr. Gil Blander About Dr. Gil Blander Dr. Gil Blander is the chief scientific officer of InsideTracker and is internationally recognized for his research in the basic biology of aging and translating research discoveries into new ways of detecting and preventing age-related conditions. He leads a team of biology, nutrition & exercise physiology experts, and computer scientists at InsideTracker, and has been featured in CNN Money, The New York Times, Forbes, Financial times, and The Boston Globe among others. Dr. Gil Blander received a Ph.D. in biology from the Weizmann Institute of Science and completed his Post Doctoral fellowship at MIT, before going on to found InsideTracker. The InsideTracker platform analyzes key biochemical and physiological markers and applies algorithms and large scientific databases to determine optimal zones for each marker. The system then provides nutrition, exercise, supplements and lifestyle interventions that empower people to optimize their markers, increasing vitality, improving overall health, as well as athletic performance and extending life. About InsideTracker InsideTracker is a personalized health analytics company founded by leading scientists, physicians, nutritionists and exercise physiologists from MIT, Harvard and Tufts University. The InsideTracker platform analyses and tracks key biochemical and physiological markers as they change over time. InsideTracker uses sophisticated algorithms and large scientific databases to determine optimal zones for each user’s markers. InsideTracker’s expert system then provides science-driven lifestyle and nutrition interventions that empower people to optimize their markers. When optimized, these marker levels have been scientifically proven to increase vitality, improve performance and extend life. Get More Wellness In Your Life Join the WFR Community on facebook Send Josh Trent a personal message Tweet me on Twitter: Send us a fun tweet (or a what's up) Comment on the Facebook page Sign up to get an email alert whenever we release a new episode Support This Podcast Leave a 5 star review on iTunes Share this episode with someone you care about Contact Wellness Force Radio for podcast sponsorship and partnership opportunities Rate & Review Wellness Force ---> REVIEW THE PODCAST Ask A Live Question For The Next Episode ---> Click here to leave a voicemail directly to Josh Trent to be read live on the air.  You May Also Like These Episodes Food Freedom Forever With Melissa Hartwig Nir Eyal: Breaking Bad Habits, Technology Addiction, & Emotional Triggers Healthy, Happy & Harder To Kill w/ Steph Gaudreau of Stupid Easy Paleo Beyond Meditation: How To Get A Better Brain With Ariel Garten Living A Healthy Lifestyle In A Modern World With Dan Pardi Creating A Life Worth Living With Michael Strasner Join the Wellness Force Newsletter: www.wellnessforce.com/news Don't miss next week's show: Subscribe and stay updated Did you like this show on Ketosis? Rate and review Wellness Force on iTunes You read all the way to the bottom? That's what I call love! Write to me and let me know what you'd like to have to get more wellness in your life.    

Jane Ferguson:                  Hi Everyone. Welcome to Getting Personal: Omics of the Heart, your podcast from Circulation Cardiovascular Genetics. I'm Jane Ferguson, an assistant professor at Vanderbilt University Medical Center and an associate editor at Circ Genetics. This is Episode 9 of the podcast from October 2017.                                                 This month we were on the road and traveled to sunny Orlando, Florida for the annual Scientific Sessions of the American Society of Human Genetics. While there, I had the chance to talk to some of the researchers presenting posters in the sessions on cardiovascular genetics and genomics, which you'll hear in just a moment. While at ASHG, we had the chance to organize a CRISPR-Cas9 genome editing boot camp. Those of you who attend a JR ATVB/PVD Scientific Sessions might have had the chance to participate in a boot camp in previous years, and this is the first time we were able to offer a boot camp at ASHG. These boot camps are based on a flipped classroom model in which the participants do some preparatory learning in advance of the meeting, and then have the chance to do hands on activities with immediate guidance from the onsite instructors. It's a really nice way to learn more about a topic, so if you're attending AHA meetings in the future, look out for the option to sign up for a boot camp while you're registering.                                                 If you haven't been able to attend a boot camp but are interested in CRISPR-Cas9 genome editing, you can access video and slide materials on the Circ Gen website at http://bit.ly/CRISPRbootcamp and the CRISPR is capitalized, so capital C-R-I-S-P-R boot camp.                                                 Moving on to the virtual poster session from ASHG, you may notice a little more background noise than usual, which will hopefully make you feel like you were right there with us at the poster session.                                                 First up, Dr. Gemma Cadby is a research fellow at the University of Western Australia and she presented a poster with data from her ongoing research into heritability of lipid species, measured through lipidomic analyses and their relationship with cardio metabolic risk traits, including blood pressure and HDL/LDL and total cholesterol.                                                 I'm here with Gemma Cadby, whose poster is entitled "Genetic Correlation of Human Lipidomic Endophenotypes and Cardio metabolic Phenotypes in the Busselton Family Heart Study". Hi Gemma, can you tell us a little about your poster? Dr. Cadby:                           Sure. So what we've done is we've taken about four and a half thousand people from an epidemiological study called the Busselton Health Study, so that's a group of people from Busselton in western Australia who were recruited initially in 1966 and they've been followed up every couple of years, and their blood was taken in 1994 and 1995. So the great thing about the Busselton Health Study is that there are a lot of related individuals, so it wasn't recruited as a family study but because it's a small town, a lot of people are related. So we didn't want to exclude those people from our analysis. Jane Ferguson:                  Right. Dr. Cadby:                           And because we don't really trust family records, because the study wasn't recruited as a family study, what we've done is we have empirically derived their relationship using the LDAK software. Jane Ferguson:                  Okay. Dr. Cadby:                           And then what we've done is we have performed targeted lipidomic profiling to quantify 530 lipid species and those are from 33 lipid classes. Jane Ferguson:                  And that's all from plasma samples? Dr. Cadby:                           Yes. And then what we did is we estimated the heritabilities. At this stage we've just done the heritabilities of the total of the sort of, of the 33 lipid classes, so those 530 species break down ... sort of can be combined into 33 classes. So we estimated the heritability of those, and then we also looked at the genetic correlation between those lipid classes and some cardio metabolic phenotypes. So, we found that 98% of our lipid species was significantly heritable, so those of the individual 530 species, and those heritabilities ranged from .12 to .52 and all of our lipid classes were also significantly heritable, with heritabilities between .15 and .5. Jane Ferguson:                  How does the LDAK software work? Do you put in genotypes, like were these subjects all genotypes- Dr. Cadby:                           So, they were genotypes on the Illumina ... Was actually on two different chips, the 610 and the 660, but we checked them in a batch of facts, and we combined them into one sample- Jane Ferguson:                  Mm-hmm (affirmative)- Dr. Cadby:                           Yep, and then LDAK adjusts for linkage between the variants, and then we used that to estimate their relatedness. And what we also did is we removed any relationships that were ... We said any relationship less than .05 to 0 so that ... With the idea being that the snips on the chip should estimate the whole genome relationships, but anything less than .05 might just be due to sort of, chance. Jane Ferguson:                  Right, right. Okay. Dr. Cadby:                           So we ran the genetic correlation between nine cardio metabolic phenotypes and the 33 lipid classes, and we found 155 of these genetic correlations who were statistically significant. Probably not surprisingly, so dystonic blood pressure wasn't genetically correlated with any lipid class, but we did find that systolic blood pressure was genetically correlated with eight of our lipid classes. Jane Ferguson:                  Did you notice any difference between the highly-heritable lipids and the non ... like the less-heritable lipids and their association with phenotypes? Dr. Cadby:                           Surprisingly, the most heritable lipid class was [asoplanetine 00:06:09] and that wasn't genetically correlated with any of our cardio metabolic phenotypes, which was quite surprising to me. Jane Ferguson:                  Right. So your next steps would be data- Dr. Cadby:                           So, what I've actually done, but is not showing on this poster, is I've now run the genetic correlation between each of the 530 lipid species and their cardio metabolic phenotypes to see whether the genetic correlations we observed were just due to, sort of a subset of lipids within that class or whether it was across all of the lipids species in that class.                                                 And we've also, I guess the exciting part, we've also got 500 whole genome sequences that we've just performing QC on at the moment. So then what we want to do is we want to see if we can use our lipid species to try to identify any genetic variance that are coarsely associated with the lipid endophenotype and then ... which would then go on to be associated with cardiovascular disease outcomes. Jane Ferguson:                  Cool. Very interesting. Have you published this or are you working on a manuscript now? Dr. Cadby:                           No I just working on it at the moment. We only got the lipidomic data in maybe June. So it's been sort of a quick ... just trying to get it done at the moment. Jane Ferguson:                  Thank you.                                                 Next I talk to Doctor Sylwia Figarska post doctorate fellow at Stanford University. She presented her research on proteomic profiling in several Swedish cohorts using the Olink platform and looking at the association of cardiovascular risk proteins with triglycerides, HDL, LDL, and total cholesterol.                                                 So I'm here with Sylwia Figarska from Stanford who has a poster entitled, "Associations of Circulating Protein Levels with Lipid Fractions in the General Population".                                                 Hi Sylwia. Thank you for agreeing to this. I would love to hear a little bit more about your poster. Dr. Figarska:                       Yeah, so I work with a Dr. Erik Ingelsson at Stanford and we were interested in pathways of association between circulating proteins and lipid levels to better understand [inaudible 00:08:30] of cardiovascular disease. Because both protein biomarkers and lipids are associated with cardiovascular disease, which is main cause of death world-wide. And so, in this study we investigated association between protein biomarkers and triglycerides, cholesterol, LDL, and HDL levels in population based cohorts.                                                 So as we study population, I used a Swedish cohort, [Epi Health - inaudible 00:09:04] cohort. So the cohort size is a little bit more than two thousand individuals. Associations at the p value collected for [FDR - inaudible 00:09:19] lower than five percent. We tested in a validation step, which was [inaudible 00:09:29] cohort also, turning a population based Swedish based cohort, and associations at P value lower than 0.05. We considered my results. Jane Ferguson:                  Okay, so what kind of things did you find? Dr. Figarska:                       Yeah, so we tested 57 proteins and 42 of them were successfully replicated for association with at least one lipid fraction. So, we found 55 blood associated with triglycerides. 15 proteins associated with cholesterol. 9 protein associated with LDL cholesterol and 24 with HDL. And then we were interested in overlap between protein biomarkers and lipid fractions. And indeed we have found some proteins that were associated with all of the lipid fractions or with, for instance, HDL cholesterol and triglycerides, because this is ... and we also looked at the parting of these associations, so this is a hit mark showing them directions of association. It's because some older proteins will associate with increase of triglycerides and at the same time will lower HDL, which is kind of expected pattern ... Jane Ferguson:                  Right. Dr. Figarska:                       ... and also this increase triglycerides and decrease HDL level is a phenotype that also is associated with insulin resistance, another phenotype I'm interested in. Yeah, so far good finds. Some interesting associations and further studies are needed to have a closer look at these patterns. Jane Ferguson:                  Right. So do you think ... are you going to follow it up with more functional analyses with these proteins to see sort of what are the functional relationships between these proteins and the lipid traits? Dr. Figarska:                       Yeah, yeah. We also might look at genetic background of these to see, which part of genetics will determine both of these proteins and lipid levels. Jane Ferguson:                  Right, interesting. So have you published any of this yet or are you working on a manuscript? Dr. Figarska:                       No, I'm working on a manuscript right now. So it's not published yet. It's new data, the results. Jane Ferguson:                  Yeah, very interesting. And I guess ... so tell me a little more about this Olink platform? So is this ... was this selected specifically for proteins that are known to be involved in cardiovascular disease? Dr. Figarska:                       Yeah, yeah. So, Olink is a Swedish company that offers partners to test protein levels and it's highly sensitive and specific assay. So for each panel you might test 92 proteins and using one microliter of blood sample, which is [inaudible 00:12:48]. Efficient and as I said it's very specific and sensitive method. And Olink effects panels of 92 proteins and for this study we used cardiovascular panel one and cardiovascular panel two and three. So, it means proteins that were like expected to be related to cardiovascular disease. And because significant panels were used in different cohorts, for this study we used those that were overlapping between these three panels to ... because then we could check them. We could check the ... validate the result. Jane Ferguson:                  Thank you.                                                 Dr. Marketa Sjogren is an associate researcher at Lund University in Sweden and spoke to me about her project investigating genetic risk scores for coronary artery disease could predict overall hospitalization burden and mortality in over 23,000 individuals from the Malmo Diet and Cancer Study.                                                 So I'm here with Marketa Sjogren from Lund University and her poster is entitled, "Elevated Genetic Risk for Coronary Artery Disease Increases Hospitalization Burden and Mortality".                                                 So, Marketa, I'd love to hear a little bit more about your research. Dr. Sjogren:                        So what we have done here is to take about 28,000 or 23,000 individuals from a study called Malmo Diet and Cancer Study, which has been previously published  [inaudible 00:14:33]. And we constructed a way to genetic risk score consisting of 50 snips for coronary artery disease as a risk. Jane Ferguson:                  And was this from previously published studies? Dr. Sjogren:                        Yes, those are from previously ... those are GWAS identified and previously published for different stuff. So these are basically at that time up to date, I think. There are some more to be included now, but at that time this was up to date.                                                 What we have done is to look whether we can, in a population based study, that is prospective study, whether we can predict if this genetic risk score, increased genetic risk score, could predict hospitalization and/or mortality. And what we see is that, that actually higher genetic risk score. So if you are in the top quintile of a genetic score, your risk of every being hospitalized for any reason increases by about 10% ... actually about 30% when it comes to cardiovascular causes. At the same time we also can see that increased genetic risk actually increases your risk to die both of any causes and particularly of cardiovascular mortality. And the strength of our study, I think, is that we actually have electronic health records, which include 100% of the population. So that we are actually sure that these people were increased and we also have the good sort of diagnosis for those, because those are hospital diagnosis. Jane Ferguson:                  Right, right. Interesting. So, even ... so for people who were hospitalized for CAD but did not have a high genetic risk score, where you able to sort of tease that out? So people who had CAD but didn't have ... had a low genetic risk but got CAD anyway? Dr. Sjogren:                        Yeah. No, we haven't actually quite look at that, but that's an interesting question because that would of course be interesting to see what else to they have and what are the environment factors that would influence the low genetic risk. Because, of course there are people with low genetic risk that will also ... Jane Ferguson:                  Yeah, they must exist. It's probably relatively small numbers. Dr. Sjogren:                        Yeah, they are probably smaller and the risk is lower, but I'm guessing that when you combine these genetic risks you can actually see quite strong with the risk of ever getting C-A-D, or CAD, or any of those other ... or any cardiovascular complication increases. Jane Ferguson:                  Yeah, interesting. So what are you hoping to do next with these data? Dr. Sjogren:                        What are we hoping to do next? Well, publish of course. That's our first step. That's the first part. And now we are actually looking into other kinds of genetic predisposition for different cardiometobolic traits. So we are currently proceeding with BMI and also type two diabetes and related phenotype. So that's our next thing, to sort of explore what kind of ... maybe what kind of hospitalization for the different cardiometobolic traits are most common for individuals for different genetic risk. Jane Ferguson:                  Yeah, yeah. That'll be interesting. That's probably people who have increased risk for genetic CAD, they also have increased genetic risk for related things, like ... Dr. Sjogren:                        Yes. Jane Ferguson:                  ... obesity and type two diabetes. Dr. Sjogren:                        That will probably be a huge overlap. But even if you look at them separately, because we have quite a big data, so you can distinguish those [inaudible – pieces]. Of course, we haven't actually looked what happen if you would, which would also be interesting to see sort of a combined cardiometobolic genetic risk. That would be an interesting challenge. Jane Ferguson:                  Right. Plenty of work to do. Dr. Sjogren:                        Yes, always. Jane Ferguson:                  Alright, thank you.                                                 Dr. Jessica Van Setten is an assistant professor at University Center Utrecht. Studying the genetics of rejection of heart transplant. She presented novel genetic loci from donors and recipients associated with acute rejection. As Jessica mentions, she's actively building a resource of data for transplant donors and recipients. So if you have access to data or samples and are interested in furthering the efforts of the International Genetics and Translational Research and Transplantation Network Consortium, you can find more information at wwww.iGeneTRAiN.org or by contacting Jessica directly.                                                 I'm here with Jessica Van Setten from Utrecht and her poster is entitled, "The Effect of Genetic Variation in Donors and Patients on Rejection After Heart Transplantation".                                                 So, Jessica thanks for talking. I would love to hear a bit more about your research. Dr. Van Setten:                 So, yeah, we are a ... I'm part of iGeneTRAin, which is an international consortium in which we try to collect as many transplants cohorts as possible that may or may not have genetic data. And so for we have genotyped over 40,000 samples of which 12,000 full donors  and recipient pairs. So this means we have DNA of the donor and of the recipient. So we can actually do ... we can check how this matches. Jane Ferguson:                  That's a really cool resource. Dr. Van Setten:                 Yeah, I think it's really exciting. It's one of the very first things I think in the world that actually does this type of research and we do need large samples size in people studies and other studies. Jane Ferguson:                  Right. Dr. Van Setten:                 So, I'm really excited to be able to show now our very first results of GWAS actually in donors and we ... so last year we have also shown the very first results of the GWAS recipients and we are working on loss of function study. So this means we are interested in genes that are absent in the recipient but are present in one or two copies of the donor. Jane Ferguson:                  Okay. Dr. Van Setten:                 So we can see if this actually ... if this specific genes pose rejection after transplantation. Jane Ferguson:                  Interesting. Okay, so what kind of things did you find? Dr. Van Setten:                 So this is actually very novel. These analyses were run only like one or two weeks ago. So, these results are the reason I didn't put the gene names here. Right now we have only a thousand donors [inaudible - in pairs for hearts]. Jane Ferguson:                  Okay. Dr. Van Setten:                 But we aim to have another at least 500 pairs by the end of next year. We will use another 600 for replication probably later this year. So what we find so far is basically a bunch of common snips that associated with rejection at year one. Jane Ferguson:                  So do you only included pairs where there was rejection at some point? Then you excluded pairs where there was a successful transplant? Dr. Van Setten:                 No, no. So this is ... actually I think we are doing pretty good at transplantation. So we have on average less than 30% rejection across all cohorts. And what we do is in this case for disposition we did genotype association to see if there was rejection at year one. Like within the first year after transplantation yes or no. And then it was basically a case control study between those.                                                 So what we aim to do in the near future is also do time to first biopsy to rejection and hopefully get more powerful analysis there. Because then you get actually time to advance as your outcome. Jane Ferguson:                  Yes, interesting. Dr. Van Setten:                 Yeah. We're really excited about it. Jane Ferguson:                  Yeah. Yes, so it looks like you found, you know, like a number of signals that genome-wide significance. Dr. Van Setten:                 We do. Yeah and that's only with a thousand samples. So, of course we do need replication to see if they are actually true, which I think is really nice. And what we aim to do after is our next sequencing experiments to see if it actually, you know, these things are expressed in the heart. So for this we have ex-plant hearts of the recipients but we also have the heart biopsies of the donor. So I work at Utrecht and there we do regular biopsies. So the first few months is actually almost every week and then it's once ... I think every six months. So we can also use those for our next sequencing experiments. Jane Ferguson:                  Wow. So they can look at like the changes in expression over time. Dr. Van Setten:                 Exactly. Jane Ferguson:                  And sort of do like as a temporal EQTL to look at its genetic predictors of expression over time. Dr. Van Setten:                 Yeah, so there is so many very nice things we can do with this. And we need a consortium, we're not the only ones doing this but we are also working on other markets like cell-free DNA and protein expression in the blood to see if we can have markers for rejection there. So we can hopefully in the future, even weeks before you can actually see the rejection in a biopsy, already prove that it's going to happen based on blood. So you don't need those invasive biopsies, you can just take a little bit of blood and check that and then say, okay, we actually need a bit more immunosuppressive drugs. Or you know, it's all fine. Maybe you can lower it a little bit and see where that ends. Jane Ferguson:                  Right, right. That's really cool. So was this done mostly in European ancestry populations or is this ... Dr. Van Setten:                 Yeah, it's mostly European. We used mixed models and we just included all we have. Because we only have such a limited sample size we decided to just go for everything and use mix models. Jane Ferguson:                  Right. Dr. Van Setten:                 So I think about the thousand samples, it's probably about 700 European samples. And the others mostly African-American ancestry and then a few Asian and other ethnic populations. Jane Ferguson:                  Yeah, really cool. So you probably ... this is like hot off the press so it's not published yet. Are you planning to write it up soon and ... Dr. Van Setten:                 Yeah. No, we are planning to write it up soon. So we may want to combine this with our loss function results and we really hope to have everything ready before, let's say, the first of January and then write it up. Jane Ferguson:                  Very cool. Dr. Van Setten:                 Yeah. Jane Ferguson:                  Anything else you want to say? Dr. Van Setten:                 Well, I do ... this is also on my poster, we really want to invite other people who may have transplant data, even if you only have phenotypic data data. You know, you have large transplant cohort collected over the years, but you don't have genotype data yet. Please do contact us, because we are always in need of more samples. Especially for heart, because right now we only have a thousand. And even if ... like in the Netherlands we were one of the largest transplant centers but we only do 12 to 15 transplants a year, heart transplants a year. So we know how difficult it is to get higher numbers of samples and we know how it must be the same for all other cohorts. So we really hope with these types of collaborations we can actually start doing genetic studies in heart transplants. Jane Ferguson:                  Interesting. Okay, so can people go to iGeneTRAiN.org ... Dr. Van Setten:                 Yes. Jane Ferguson:                  ... and then find your contact details? Dr. Van Setten:                 For sure. Jane Ferguson:                  Or maybe email you directly and ... Dr. Van Setten:                 That's also fine. Yeah. So you can email me on j.vansetten@unu.transplant.nl. Jane Ferguson:                  Awesome. Alright, thank you Jessica. Dr. Van Setten:                 Yeah. Jane Ferguson:                  I'd like to give a special thanks to all the poster presenters who agreed to share their unpublished research with you via this podcast. And I'd like to thank you for listening. Talk to you next month.