Podcasts about Bace

Is LA's New Mayor Hiding a COMMUNIST Agenda?Become a supporter of this podcast: https://www.spreaker.com/podcast/radio-baloney-the-richie-baloney-show--4036781/support.

From NBAA-BACE 2024, Keith Clark - senior quality control and technical rep at Phillips 66, discusses how the Safe a Life, Verify Fuel Type is growing and making a positive impact on the aviation industry. 

Terry Yeomans, director of the IS-BAH program at IBAC, spoke with Ground Support Worldwide editor Josh Smith during NBAA-BACE about the importance of safety management systems in the business aviation industry as well as the IS-BAH program's 10th anniversary.

Listen in as Aviation Week's Jeremy Kariuki, Molly McMillin, Bill Carey and Guy Norris discuss the latest news, live from NBAA-BACE in Las Vegas, Nevada.

The 2024 NBAA Business Aviation Convention & Exhibition is the industry's largest and most dynamic international gathering, and this year's edition in Las Vegas promises to be a show unlike any other. The post Podcast: Check out the Must-See Highlights of 2024 NBAA-BACE appeared first on NBAA - National Business Aviation Association.

Join Aviation Week Network's Jeremy Kariuki, Molly McMillin and Bill Carey as they discuss sustainable aviation fuel, Textron, Lilium and more leading up to the 2024 NBAA Business Aviation Convention & Exhibition in Las Vegas, Nevada.

Good morning from Pharma and Biotech daily: the podcast that gives you only what's important to hear in Pharma e Biotech world.Bristol Myers has received approval for a first-of-its-kind schizophrenia drug, Cobenfy, and plans to sell it despite potential insurance barriers for patients. Biogen and UCB are planning a large study for their lupus medicine, Biohaven is seeking approval for a neurological disorder drug, and Amgen claims success for immune drugs. Scientist.com discusses streamlining IND applications for cell and gene therapy innovations, while Arch raises $3 billion for a biotech fund. The article also covers strategies to keep clinical trials on schedule and provides insights into the market strategies of drugmakers. Additionally, upcoming events and trending news in the biopharma industry are highlighted. Biopharma Dive offers in-depth journalism and insights into the biotech and pharma industries, covering topics such as clinical readouts, FDA approvals, gene therapy, drug pricing, and research partnerships.Bristol Myers Squibb (BMS) has received FDA approval for KarXT, the first new schizophrenia therapy in 35 years. The drug targets muscarinic receptors and is considered ahead of competition from AbbVie and Neurocrine Biosciences. Pfizer's withdrawal of Oxbryta has left the sickle cell community scrambling, as the therapy was predicted to reach $750 million in sales. Sanofi and Regeneron's Dupixent has received approval for use in chronic obstructive pulmonary disease. The FDA's oncology drugs advisory committee has recommended limiting the use of Keytruda and Opdivo in stomach and esophageal cancer patients with low PD-L1 expression. Additionally, AbbVie's acquisition of Cerevel is showing promise with a phase III win in Parkinson's disease. Cassava has agreed to pay a $40 million fine to resolve an SEC probe, while Roche is looking to push Gazyva into lupus nephritis with positive late-stage data. Lilly is facing scrutiny over drug pricing compared to Novo Nordisk. The BACE credential is highlighted as a way to advance a career in the biotech industry.Senators have introduced a bill to establish cybersecurity standards for healthcare providers, health plans, and business associates. A study found that hospital acquisitions provide a one-time efficiency boost to margins but do not continue to improve operating metrics in the long term. Canopy CEO Shan Sinha discusses healthcare workplace violence and technology's role in protecting workers. The unexpected consequences of hospital quality scores are explored, suggesting a reexamination of the federal hospital-acquired condition reduction program. AI is being integrated into healthcare to give back time and prioritize people in day-to-day tasks. In other news, hospitals in Florida are preparing for Hurricane Helene, a major U.S. prison is criticized for substandard healthcare, and families in states banning health care for transgender teens may have to travel for care. Healthcare Dive provides in-depth journalism on topics such as health IT, policy, insurance, and more for decision-makers in the industry.The FDA recently approved Bristol Myers Squibb and Karuna Therapeutics' new drug, KarXT, now known as Cobenfy, for schizophrenia. This marks the first new mode of action approved for the condition in decades. The drug showed promising results in clinical trials, with patients on Cobenfy actually losing weight compared to gaining weight on other medications. However, there is still room for improvement as over 50% of patients discontinued treatment. The approval of Cobenfy highlights Bristol Myers Squibb's deal-making skills and sets the stage for a new generation of treatments for schizophrenia. Other upcoming drugs in the field may further shake up the market. Pharmaceutical companies are continuously working on market strategies to successfully launch new drugs post-FDA approval, as turning a new drug into a successful asset remains a challenge in the

Good morning from Pharma and Biotech daily: the podcast that gives you only what's important to hear in Pharma and Biotech world. Various developments in the biopharma industry are discussed, including Novo's CEO being pressured to cut prices of obesity and diabetes drugs, the FTC suing major pharmacy benefit managers over insulin prices, Bluebird laying off another 25% of its workforce, and Apellis' eye drug being turned down in Europe. Large pharmaceutical companies face challenges as patent protections for their blockbuster drugs expire, forcing them to find new products and markets. Resources are provided on topics such as oncology research, AI in clinical research, overcoming clinical trial delays, and creating compelling biopharma data packages.Masimo CEO Joe Kiani resigned following a proxy battle with an activist investor, and Michelle Brennan was named as the acting CEO. Medtronic and Siemens Healthineers partnered on spine surgery, with Siemens integrating its robotic x-ray imaging system with Medtronic's spine surgery suite. Roche launched a test that can detect 12 respiratory viruses simultaneously, including influenza and COVID-19. The FDA appointed Ross Segan to lead the office responsible for premarket authorizations and recalls. A study found that only 30 out of 157 heart devices with class I recalls had undergone premarket clinical testing.The text discusses various healthcare-related news and insights for healthcare leaders on September 25, 2024. It highlights the need for more oversight in remote patient monitoring in Medicare to avoid fraud and misuse, as well as the increasing number of claims denials reported by providers. The Department of Health and Human Services is set to invest nearly $75 million in rural healthcare, focusing on expanding substance use disorder treatment and maternal healthcare services.Amgen's immune drugs for eczema and myasthenia gravis met their objectives in phase 3 trials, but results underwhelmed Wall Street. Novo's CEO was pressed by the Senate to cut prices of obesity and diabetes drugs. Struggling 2seventy scrapped a key cancer study to save money in the near term. Biogen and UCB received long-awaited lupus data. To improve cancer treatments, the nonprofit Cancer Research Institute aims to foster partnerships between scientists and the pharmaceutical industry.Merck's Keytruda combination therapy failed in a phase III colorectal cancer study, following a similar outcome for Bristol Myers Squibb in December 2023. Amgen saw late-stage wins in eczema and myasthenia gravis, with mixed results according to analysts. Novo Nordisk's CEO agreed to meet with PBMs on pricing for Ozempic and Wegovy, which are expected to dominate the next round of Medicare price negotiations in 2025. The BACE credential is recommended for those seeking to advance their biotech career.Sour Patch Kids has created a translator app to simplify corporate jargon for Gen Z entering the workforce. Mazda's new brand platform aims to enhance customer experiences and community activations. TikTok has updated its search ads with keyword targeting, while Firehouse Subs brings back its hot sauce bar with a new campaign. Coca-Cola is discontinuing its spiced flavor after just 7 months.Regeneron's Eylea empire is facing challenges as competitors launch biosimilars of the blockbuster eye drug. Sales of Eylea have decreased while Roche's drug Vabysmo has seen a significant increase in sales. Additionally, gene therapies are entering late-stage trials for wet AMD, potentially changing the treatment landscape dominated by Eylea.Novo Nordisk and Eli Lilly are investing billions in licensing and M&A deals to expand their obesity pipelines beyond GLP-1s, solidifying their dominance in the market. Regulators and policymakers are urged to create incentives to make MPoX a more attractive investment opportunity to effectively combat disease. Cancer and diabetes drugs are predicted to dominate the 2025 Medicare ne

Good morning from Pharma and Biotech daily: the podcast that gives you only what's important to hear in Pharma and Biotech world.On September 23, 2024, Lifespan, a healthcare organization, laid off 20% of its executive team as part of a restructuring effort to save $6 million. The FTC sued major pharmacy benefit managers over alleged anticompetitive practices related to insulin prices. Texas Attorney General settled with a generative AI company over accuracy allegations. Steps to minimize the threat of legacy medical devices and the challenges faced by telehealth providers in navigating insurance, compliance, and cash-only models amid state regulations were discussed. The changing landscape of healthcare requires workforce planning strategies to address staffing challenges. Placing AI at the heart of healthcare to improve efficiency and patient care is also highlighted. Additionally, news on cybersecurity risks posed by legacy medical devices, challenges faced by telehealth providers, and industry developments such as new diet plans and games for falls prevention were shared. Healthcare Dive provides in-depth journalism on topics such as health IT, policy & regulation, insurance, digital health, payer-provider partnerships, and value-based care for decision-makers in the healthcare industry.In other news, AstraZeneca and Daiichi's dato-dxd failed to extend lives in breast cancer, adding to previous setbacks in lung cancer. Bristol Myers Squibb is targeting the first new type of schizophrenia drug in three decades. A recent court ruling has revived PhRMA's legal challenge to the Inflation Reduction Act. BMS is laying off employees in New Jersey as part of cost-saving measures. BMS' karxt could soon be the first new schizophrenia drug in decades. Sanofi secured approval for Sarclisa in multiple myeloma and Athira Pharma laid off 70% of its workforce. The BACE credential can help advance a career in biotech. The ongoing battle over drug pricing was also discussed, specifically focusing on insulin and the role of pharmacy benefit managers (PBMs) in inflating costs. The U.S. Federal Trade Commission filed a lawsuit against three major PBMs for allegedly rigging the supply chain to increase insulin prices. Insulin makers like Eli Lilly have set price caps, but the FTC warned all drugmakers about raising list prices for medicines. Big pharma companies are being scrutinized for their efforts in providing access to drugs like insulin in low- and middle-income countries. A report examined the patient reach efforts of 20 major pharma companies in these regions. Overall, the industry is facing pressure to address both pricing and access issues.

This is our second episode of Season 2 and today we are talking to Erin Ronder Neves, a birth and postpartum doula, about her experiences with Postpartum Depression and OCD. In this episode, Erin shares candidly about the intrusive thoughts she experienced and the support she sought to help her through this frightening experience. We wanted to link to this helpful article to help you understand how intrusive thoughts and OCD work and how they are different to postpartum psychosis: https://www.cedars-sinai.org/blog/difference-between-postpartum-anxiety-ocd-psychosis.html Unlike postpartum OCD, postpartum psychosis is a medical emergency and visiting your nearest emergency room is the appropriate response. On the Resilient Birth podcast, Justine and Sarah explore the impact of trauma in the perinatal period. Through an inspirational quote that drives the weekly content, Justine and Sarah explore various trauma areas with vulnerability and compassion that support birthing people and birth professionals. Each week, listeners leave with takeaways to utilize in their lives and/or clients. Justine and Sarah hold the stories they share with honor and respect with the hope to impart knowledge, increase understanding, and bear witness to this challenging topic. Sarah is a licensed mental health counselor, educator, and mom of three. She walks with a story of trauma from before and as a result of her perinatal experience. Justine supports survivors of trauma through perinatal coaching and childbirth education. As well as being a mother of three, she holds a Ph.D. on representations of consent and sexual violence. Erin Ronder Neves started birth work after the birth of her second daughter, but it was the birth and postpartum experience of her first daughter that initially opened her eyes to all the empowering opportunities that birthing people are not made aware of on their journey. Erin is a certified Birth Doula who has supported over 275 births. She is also a postpartum doula and has worked with just as many families during the postpartum period, as she believes that support should continue once someone gives birth instead of well wishes and one follow-up visit which is usually 6 weeks after birth. Throughout the years, Erin has tacked on a few additional letters after her name to become a Certified Childbirth Educator through BACE, A Certified Lactation Counselor, and a Spinning Babies Parent Educator. And of course, Erin is a proud graduate of Resilient Birth's Trauma Informed Training. Erin started her doula and education business, ERN Doula, back in 2020, and is currently about to launch a brand new brick and mortar location on the North Shore of MA in Beverly, MA, called Beyond Birthing. Doors will open in mid June! Beyond Birthing is the first of its kind, all-inclusive prenatal and postpartum support center. Under one roof families will be able to have access to FULL TIME chiropractic services, lactation consultant, perinatal mental health clinicians, maternal nutritionist, massage therapy, caregiver education groups and so, so many support groups. The mission of Beyond Birthing is focused on the caregivers! Beyond Birthing will allow caregivers to prioritize their own mental health and physical wellbeing, and is dedicated to making it easier to do so. Feel free to check out her website: www.beyondbirthingvillage.com Learn more about our course called Trauma Informed Fundamentals here: https://resilient-birth.mykajabi.com/traumainformedfundamentals

Discusses how you can leverage Biotility's educational offerings for talent development and career growth in the biosciences.  Our guest today is Tamara Mandell, the Director of the Education and Training Programs at Biotility, a leader in biotech education and training. Tamara has more than 12 years of combined academic research and industrial biotechnology experience and is fluent in the techniques, methodology, and regulatory compliance relevant to the applied sciences.  Additional resources: Biotility: https://biotility.research.ufl.edu/ BACE: https://biotility.research.ufl.edu/bace/ Biotility Courses Available on CITI Program: https://about.citiprogram.org/series/biotility-at-the-university-of-florida/ InnovATEBIO: https://innovatebio.org/ Biotech Careers: https://www.biotech-careers.org/careers Bio-Rad Biotechnology Textbook & Program: https://www.bio-rad.com/en-us/a/edu/biotechnology-textbook-program 

Mention his name today, and most will recognize Tim Fedewa as the longtime spotter for Kevin Harvick. But like so many other folks up in the spotter's stand, Tim began his career as a driver in and around his home state of Michigan.   He eventually moved south to go Busch Series racing with Ray and Diane DeWitt, who took him to his first win in 1995 at Nazareth. Tim wound up at BACE Motorsports, where he had a front-row seat to the chaos … and success … of teammates Randy LaJoie, crew chief Steve Bird, and team owner Bill Baumgardner.    Tim then ran into his OWN contractual issues with the team, which prevented him from landing a ride that turned out to be one of the most successful in Busch Series history.    We then tackle the May 25, 1995 issue of Winston Cup Scene.    A bad storm gets things kicked off at Charlotte the weekend of The Winston Select all-star race. Jeff Gordon fires up his Hendrick Motorsports crew before going out and putting it to the rest of the field in the main event.    Kenny Schrader races his way into the all-star race, just a week after losing part of his thumb in a freak accident. And then has a bit of a rough encounter with Mr. Excitement, Jimmy Spencer. Dale Earnhardt and Darrell Waltrip try to make a run on Gordon in the final ten-lap shootout but wind up running into each other and crashing.    Plus, future high-ranking NASCAR official Elton Sawyer gets whacked with a penalty. Tim Fedewa wins the first race of his Busch Series career at Nazareth by stretching his fuel supply and staying out of the carnage in the first half of the event.    Chad Little weighs racing against law school … and racing almost wins, before momma and daddy step in. Finally, Kyle Petty REALLY wants to get to Memphis on time during his annual cross-country motorcycle ride, so he can visit Graceland, home of his hero, Elvis Presley. NOTE: This show is not associated in any way with American City Business Journals, owner of the Scene brand.   Be sure to check out the latest and greatest stories from the world of NASCAR at dailydownforce.com! Interested in The Scene Vault Podcast T-shirts? Check out thescenevault.com and click on SHOP to see what we have available! Please consider supporting this show via: patreon.com/thescenevaultpodcast paypal.me/thescenevaultpodcast venmo.com/thescenevaultpodcast Learn more about your ad choices. Visit megaphone.fm/adchoices

BUFFALO, NY- February 15, 2024 – A new #research paper was #published on the #cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 3, entitled, “GV1001 reduces neurodegeneration and prolongs lifespan in 3xTg-AD mouse model through anti-aging effects.” GV1001, which mimics the activity of human telomerase reverse transcriptase, protects neural cells from amyloid beta (Aβ) toxicity and other stressors through extra-telomeric function, as noted in our prior in vitro studies. As per a recent phase II clinical trial, it improves cognitive function in patients with moderate to severe dementia. However, the underlying protective mechanisms remain unclear. In this new study, researchers Hyun-Hee Park, Hyuk Sung Kwon, Kyu-Yong Lee, Ye Eun Kim, Jeong-Woo Son, Na-Young Choi, Myung-Hoon Han, Dong Woo Park, Sangjae Kim, and Seong-Ho Koh from Hanyang University Guri Hospital, Hanyang University Graduate School of Biomedical Science and Engineering and Teloid Inc. aimed to investigate the effects of GV1001 on neurodegeneration, senescence, and survival in triple transgenic Alzheimer's disease (AD) (3xTg-AD) mice. “ [...] we hypothesised that GV1001 might have anti-aging effects and improve neurodegeneration and senescence in vivo as a possible mechanism for its beneficial effects on AD.” GV1001 (1 mg/kg) was subcutaneously injected into old 3xTg-AD mice thrice a week until the endpoint for sacrifice, and survival was analysed. Magnetic resonance imaging (MRI) and Prussian blue staining (PBS) were performed to evaluate entry of GV1001 entrance into the brain. Diverse molecular studies were performed to investigate the effect of GV1001 on neurodegeneration and cellular senescence in AD model mice, with a particular focus on BACE, amyloid beta1-42 (Aβ1-42), phosphorylated tau, volume of dentate gyrus, β-galactosidase positive cells, telomere length, telomerase activity, and ageing-associated proteins. GV1001 crossed the blood-brain barrier, as confirmed by assessing the status of ferrocenecarboxylic acid-conjugated GV1001 using magnetic resonance imaging and PBS. GV1001 increased the survival of 3xTg-AD mice. It decreased BACE and Aβ1-42 levels, neurodegeneration (i.e., reduced CA1, CA3 and dentate gyrus volume, decreased levels of senescence-associated β-galactosidase positive cells, and increased telomere length and telomerase activity), and levels of ageing-associated proteins. “We suggest that GV1001 exerts anti-ageing effects in 3xTg-AD mice by reducing neurodegeneration and senescence, which contributes to improved survival.” DOI - https://doi.org/10.18632/aging.205489 Corresponding authors - Sangjae Kim - chiron@gemvax.com, and Seong-Ho Koh - ksh213@hanyang.ac.kr Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Voamos para Las Vegas onde cobrimos a maior feira da aviação executiva mundial a NBAA | BACE 2023 Visite o site Porta de Hangar: www.portadehangar.com.br Conheça o site do fotógrafo Ricardo Beccari www.beccariphoto.com.br @ricardobeccari @Porta de Hangar O canal da aviação

A Najeriya wata babbar matsala da ake fama da ita a kasar ita ce yawaitar satar kananan yara musamman a yankin arewacin kasar, inda bayanai ke cewa bayan sace su, ana safarar su ne zuwa wasu yankuna da ke kudancin kasar.  Malam Ibrahim Yunusa Ibrahim da ke zaune a Gwagwalada kusa da Abuja, daya ne daga cikin gungun iyalai fiye da 50 wadanda aka sace ‘yayansa, kuma yanzu haka suke ci gaba da nema, ya yi wa Abdoulkarim Ibrahim Shikal karin bayani a game da wannan matsalar. Ku latsa alamar sauti don sauraron cikakkiyar hirar.

In a continuation of our Deux episode from this season, today the Sunbaes, along with guest host Serin, jump into the history of D.Bace! Join us as we talk about this interesting first-generation boy group!--Check out our website!kpopsunbaes.com--Our Scripthttps://tinyurl.com/DBaceDeepDive--Where To Find UsTwitter: kpopsunbaesInstagram: kpopsunbaesTumblr: kpopotd, kpopotd2, kpopsunbaesYouTube: The K-Pop SunbaesFacebook: The K-Pop SunbaesTikTok: kpopsundae--AttributionsCover Art - Elyse Shewan (Instagram: @es.graphic.design)Music by Joystock - https://www.joystock.org

Recorded live from NBAA-BACE 2023 in Las Vegas, Jeremy Kariuki, Molly McMillin, Guy Norris, Lee Ann Shay and Bill Carey share their favorite moments from the show. This episode was produced by Guy Ferneyhough and engineered by Jeremy Kariuki.

NBAA's annual Business Aviation Convention & Exhibition (NBAA-BACE) is coming to Orlando, FL, Oct. 18-20. To make the most of your time at our industry's premier event, NBAA's Maureen Cameron recommends attendees start planning for their show experience today.

Deciding how to nourish our body and minds can be an obstacle to self-care—but you can use the BACE framework to create your self-care toolkit. Join Joy Ofodu today to learn more. Grab that journal! Bring the employee wellbeing program based on Shine's award-winning app to your team, school or workplace with one simple step. Refer your HR leader to make Shine your newest wellness benefit and get a free year of Shine Premium for yourself. Learn more at theshineapp.com/work

Playlist: Vise pjevaca - StorijaMladen Janus - Ticeki maliNHT - Proljece zivotaBace iz Bosnjaka - TemeljasiTS Ravnica - Lipa moja SlavonjoMate Bulic - Dome mojAnamary Bicanic - Medjimurje mojeIvica Pepelko - Na ValentinovoMeri Cetinic - Umrit za ljubavGrupa Happiness - Vatromet zelja

シナモンブレッドだよねーって終盤言ってますが、シナモンロールの間違いでした。 ------------------------------------------ Twitter（更新お知らせ他） https://mobile.twitter.com/umeshio_desu note（最近時々書いてる） https://note.com/umeshidesu 感想や相談などのおたより募集中 RadiotalkアプリまたはWebブラウザで https://radiotalk.jp/program/5088 に飛んだ先から送れます。 ------------------------------------------- #うめしお2202 #2022うめしおのお返事

In this episode of the podcast we talk with NEW Members ThatGuyBace and WavysTV about their backgrounds and the goal is moving forward for their personal content and Team Vove! We're now hosting the VoveCast Live on YouTube on Saturday evenings, so be sure to join the Discord and follow us on Twitter to know when we're going live! Website: https://team-vove.com Twitter: https://twitter.com/TeamVove YouTube: https://www.youtube.com/c/teamvove Discord: https://discord.gg/UBjPUMd Linktree: https://linktr.ee/teamvove --- Support this podcast: https://anchor.fm/vovecast/support

La Araña Fm, enters with a new trailer where black metal and industrial is part of our podcast. Now for our listeners we present our new dark electro section. Featuring groups like: SynthAttack, AngstSystem, Funker Voght, Soman. PLAYLIST SynthAttack Dirty Dark Electro. AngstSystem, Warmes Fleish. Fuker Voght, Date of Experation. Soman, Bace. Antibody, Ruined Conflict, Sorrow. Sea of Sin, What Are You Waiting for. #blackyear. --- Send in a voice message: https://anchor.fm/ebmschifter/message

The National Business Aviation Association's annual convention was held in person earlier this month for the first time in two years. Last year, NBAA canceled its traditional convention due to the pandemic but held a scaled-down virtual show. This year's event took place in the new West Hall of the Las Vegas Convention Center and included a Covid vaccination requirement to attend. In this podcast episode, AIN editor-in-chief Matt Thurber and senior editor Kerry Lynch discuss how the show went and what exhibitors thought about the lighter attendance. This podcast is sponsored by business aviation sustainability solutions company 4AIR.

Season 2 Episode 19 - Your hosts spent time together talking about experiences and observations from this year's NBAA BACE. This conversation includes a discussion around the evolution of the industry and hypothesizing about where the hosts feel like the industry will go in time. If you attended BACE we would love to hear your experiences and observations compared to previous years. We appreciate your feedback and support! --- Send in a voice message: https://anchor.fm/jet-blast/message

NBAA-BACE, HondaJet 2600 Concept Light Jet, Cirrus Vision Jet, Diamond all-electric trainer, KC-46 tanker, airline ticket refunds, smuggling, Australia News Desk.

In anticipation of the National Business Aviation Association's Business Aviation Connference and Exhibition—or NBAA-BACE—next month in Las Vegas, AIN Washington, D.C. editor Kerry Lynch speaks about the return of the first in-person industry trade show since the pandemic began. Lynch discusses the brand-new exhibit hall for the show, planned Covid protocols—including vaccination requirements—and how things are going in terms of scheduled exhibitors, as well as the debut of owner-pilot and maintenance pavilions. There will also be on-site and virtual sessions and Corporate Angel Network's annual fundraiser cocktail reception. Podcast sponsored by 4AIR.aero.

Splitting time between Brooklyn, New York and Hilo, Hawai'i- Joey Trisolini grew up in a small town named Ka'a'awa on the east side of Oahu, Hawai'i. An otherwise unknown little town with only 1300 residents, its claim to fame is a short clip in the Hollywood surfing movie Blue Crush, showcasing Ka'a'awa's tiny elementary school. Joey got into skateboarding at the age of 13 and used disposable cameras to document his friends, dropping each roll off at the local 7-11. Skateboarding and taking photos came hand in hand. After a short stint of documenting life in Italy and New Mexico, he eventually took the plunge and moved to New York to join a friend working at Milk Studios. This became a jumping off point to assist some of the world's leading fashion and advertising photographers for the next 6 years, working on campaigns for Dior, Calvin Klein, Prada and many others. Clients include: Amazon, Kona Brewing Company, H&M, Monocle Magazine, Saturday's Surf NYC, Noah NYC, Salvage Public, Shopbop, Flux Magazine, Nella Media Group, Koa Skincare, Waialae Sportswear, Vivo, Dosely, Bace, Lafayette 148, UBS Bank, Ladder, Eventbrite, Young Living, Florence Marine X, Channel Islands. CONTACT studio@joeytrisolini.com 1002 Metropolitan Ave Brooklyn, NY 11211. Instagram: @jtrisolini --- Send in a voice message: https://anchor.fm/theholoholopodcast/message Support this podcast: https://anchor.fm/theholoholopodcast/support

The guys discuss new aircraft deliveries and debate what is the best type rating to have [00:30] // Flight Advice: New CFI struggling to find work [20:45] // NBAA's Phil Derner joins us to share the latest on NBAA BACE and why attending is a great investment of time and resources [31:00] // Phil explains the world of planespotting [49:30] // We ask Phil what it was like to be an aviation consultant for national TV networks and appear Air Disasters and other shows [101:37] Show resources: NBAA BACE 2021 Info Phil Derner's LinkedIn | Aviation Photos 21.Five Podcast's LinkedIn Get your 21.Five Coffee Cup by donating $85 here Our sponsors: Harvey Watt, offers the only true Loss of Medical License Insurance available to individuals and small groups. Because Harvey Watt manages most airline's plans, they can assist you in identifying the right coverage to supplement your airline's plan. Many buy coverage to supplement the loss of retirement benefits while grounded. Visit harveywatt.com to learn more! Advanced Aircrew Academy enables flight operations to fulfill their training needs in the most efficient and affordable way—in any location at any time. We do this by providing high-quality professional pilot, flight attendant, flight coordinator, maintenance, and line service training modules delivered via the web using a world class online aviation training system. Visit aircrewacademy.com to learn more!  Do you have feedback, suggestions, or a great aviation story to share? Email us info@21fivepodcast.com Check out our Instagram feed @21FivePodcast for more great content and to see our collection of aviation license plates. The statements made in this show are our own opinions and do not reflect, nor were they under any direction of any of our employers. 

8e émission de la 50e session... Cette semaine, jazz moderne et électro-jazz! En musique: Paul Bedal sur l'album Mirrors  (Bace, 2018); Mario Pavone Dialect Trio + 1 sur l'album Blue Vertical  (Out of Your Head, 2021); Danilo Gallo Dark Dry Tears sur l'album A View Through a Slot  (Clean Feed, 2021); Unscientific Italians sur l'album Play the Music of Bill Frisell Vol. 1  (Hora, 2021); Portico Quartet sur l'album Terrain  (Gondwana, 2021); Michael Wollny sur l'album XXXX  (ACT Music, 2021)...  

8e émission de la 50e session... Cette semaine, jazz moderne et électro-jazz! En musique: Paul Bedal sur l'album Mirrors  (Bace, 2018); Mario Pavone Dialect Trio + 1 sur l'album Blue Vertical  (Out of Your Head, 2021); Danilo Gallo Dark Dry Tears sur l'album A View Through a Slot  (Clean Feed, 2021); Unscientific Italians sur l'album Play the Music of Bill Frisell Vol. 1  (Hora, 2021); Portico Quartet sur l'album Terrain  (Gondwana, 2021); Michael Wollny sur l'album XXXX  (ACT Music, 2021)...  

When self-care feels overwhelming: Having a menu of tools that work for you can be a gamechanger. Today, Mel guides you through the BACE framework to help you pinpoint your favorite self-care practices. Grab that journal! Voiced by Mel Chanté. Takeaways: 1- Taking care of ourselves is a daily practice—and you’ve already learned tools that work best for you. 2- Use BACE as your guide to self-care: body care, achievement, connection, and enjoyment. 3- Check in with how you feel and seek out activities that light up each area of your life. Mantra: I nourish my body and mind. --- May is Mental Health Awareness Month. Get extra support and tools to calm your anxiety with Shine Premium, your personalized self-care membership. You’ll get access to over 1,000+ meditations created by diverse experts, personalized journaling prompts, content based on your mood, and invites to monthly community care events. Become a Shine Premium member today and get $10 off your first year by signing up at theshineapp.com/member.

Mai baiwa shugaban Najeriya shawara kan harkokin tsaro janar Babagana Manguno yace shugaban kasa Muhammadu Buhari ya bada makudan kudade domin sayo makamai, amma ya zuwa yanzu babu wanda ya san inda wadannan makamai suka shiga. Wadannan kalamai sun harzuka yan Najeriya wadanda ke nuna bacin ran su akai ganin yadda matsalar tsaro ta addabi kasar take kuma cigaba da dibar rayuka. Dangane da wannan batu, Bashir Ibrahim Idris ya tattauna da Janar Idris Bello Dambazau mai ritaya, kuma ga yadda zantawar su ta gudana. Yan lokuta bayan wannan hira ,janar Babagana Manguno ya musanta cewa ya fadi haka.

In this episode, Jacques covers papers from January 2021 on the mechanisms of APP processing in Alzheimer's disease and strategies to alter amyloid-beta production. Learn something new as we explore pathways associated with increased amyloid-beta production, the development of BACE inhibitors and recent clinical trial findings!  ------------------------------------------------------------------  Click here to see the list of papers covered in this episode.To access the folder with the bibliographies for the month of January, follow this link (it will be updated as we publish episodes and process bibliographies), or click the following link below:https://drive.google.com/drive/folders/1tKnPbfs5Uedi86weYxorCNpQqC7BfD7P?usp=sharingYou can also join our mailing list to receive a newsletter once per month by filling this form. Or tweet at us: @AMiNDR_podcast  ------------------------------------------------------------------ We would appreciate your feedback so we can better cater to your needs.  You can fill our feedback form here:    ---------->  https://forms.gle/5aq2JyrT6g4P1m8v6  You can also share your thoughts and suggestions by contacting us:  Email: amindrpodcast@gmail.com  Facebook:  AMiNDR  Twitter: @AMiNDR_podcastInstagram: @AMiNDR.podcast------------------------------------------------------------------ Every episode of AMiNDR is the result of a huge team effort. Today's episode was scripted and hosted by Jacques Ferreira, reviewed by Sarah Louadi, and edited by Sanjana Bedi. Big thanks to Elyn Rowe, Jacques Ferreira and the rest of the sorting team for sorting all the papers published in January into themes for our episodes, to our managers Sarah Louadi and Ellen Koch for keeping everything running smoothly, and props to the whole team that works very hard behind the scenes to make all this possible. Our music is from "Journey of a Neurotransmitter" by musician and fellow neuroscientist Anusha Kamesh; you can find the original piece and her other music on soundcloud under Anusha Kamesh or on her YouTube channel, AKMusic.   https://www.youtube.com/channel/UCMH7chrAdtCUZuGia16FR4w   ------------------------------------------------------------------ If you are interested in joining the team, send us your CV by email. We are specifically looking for help with abstract summary and podcast editing. However, if you are interested in helping in other ways, don't hesitate to apply anyways.  ------------------------------------------------------------------ *About AMiNDR: *  Learn more about this project and the team behind it by listening to our first episode: "Welcome to AMiNDR!" 

*Leading advanced levels of collaboration between colleges and employers including HBCUs and PWIs.* Identifying and address unique needs and challenges of institutional and organizational policies that affect education, hiring, retaining and developing equity in inclusive and diverse talent.* Establishing scholarship, mentoring and coaching initiatives that support inclusive populations and business.* Generating career opportunities for diverse populations in higher ed, organizations and communities.* Inspiring and leading the development of academic research and training that supports professional excellence and organizational transformation.https://bacecareers.comWith an ever-changing workplace environment and market, Shannon Stone Consulting works as your as your COO concierge team. With our social good entrepreneur services, you can be confident that your project, event, department or non-profit will have the perfect partner in your corner.https://shannonstoneconsulting.comFollow:https://www.linkedin.com/company/shannonstoneconsulting/https://www.facebook.com/ShannonStoneConsulting/https://www.linkedin.com/company/bacecareers/https://www.facebook.com/bacecareers/Support the show

The House Supply crew join us for episode 102.

In this episode, Marcia covers papers published in September 2020 that focus on the latest in novel drug development in AD. We especially talk about papers targeting amyloid-beta aggregation, BACE-1 inhibitors, gamma-secretase, immunotherapy for AD and more! Tune in to learn more. 5:46 - BACE-1 9:09 - Gamma secretase11:12 - More papers on amyloid-beta aggregation------------------------------------------------------------------  To receive the list of papers covered, please fill this form:  -------->  https://forms.gle/CVVbznAFM8pamdgk6  -------  or by tweeting at us: @AMiNDR_podcast  ------------------------------------------------------------------ We would appreciate your feedback so we can better cater to your needs.  You can fill our feedback form here  ---------->  https://forms.gle/5aq2JyrT6g4P1m8v6  You can also share your thoughts and suggestions by contacting us:  Email: amindrpodcast@gmail.com  Facebook:  AMiNDR  Twitter: @AMiNDR_podcastInstagram: @AMiNDR.podcast------------------------------------------------------------------ Today's episode was scripted and hosted by Marcia Jude, reviewed by Elyn Rowe, and edited by Alexandra Pavel. Big thanks to Elyn Rowe and Jacques Ferreira for sorting all the papers published in September into themes for our episodes, and props to the team that works very hard behind the scenes to make all this possible. Our music is from "Journey of a Neurotransmitter" by musician and fellow neuroscientist Anusha Kamesh; you can find the original piece and her other music on soundcloud under Anusha Kamesh or on her YouTube channel, AKMusic.   https://www.youtube.com/channel/UCMH7chrAdtCUZuGia16FR4w   ------------------------------------------------------------------ If you are interested in joining the team, send us your CV by email. We are specifically looking for help with abstract summary and podcast editing. However, if you are interested in helping in other ways, don't hesitate to apply anyways.  ------------------------------------------------------------------ *About AMiNDR: *  Learn more about this project and the team behind it by listening to our first episode: "Welcome to AMiNDR!"  

20201122 Mukunda's Arrest by the Toll Collectors @ Mayapur, India © JPS ARCHIVES 2020

Indonesia's and China's technology ecosystems continue to interweave and overlap. BAce Capital is a venture firm whose very mission is to connect markets such as Indonesia to China's dynamic tech eco-system. Claiming Ant Financial as its anchor LP, the firm was founded by Ant and Alibaba veterans Benny Chen and "KK" Kshitij Karundia. In this instalment of Sino Indo Tekno with Art Dicker and Allan Hellawell, Benny reflects on the many benefits that the Indonesian entrepreneur can realize in working closely with his/her counterparts in China. How do companies in China scale? What are best practices in product development? What are the most powerful ways to leverage big data? Benny profiled a number of activities that his team has arranged for BAce Indonesian portfolio companies such as Printerous and RoomMe. Learning visits to meet industry peers in China helped answer questions such as those above, while focused workshops on Chinese COVID mitigation techniques offered these companies valuable coping mechanisms for the pandemic.

Indonesia's and China's technology ecosystems continue to interweave and overlap. BAce Capital is a venture firm whose very mission is to connect markets such as Indonesia to China's dynamic tech eco-system. Claiming Ant Financial as its anchor LP, the firm was founded by Ant and Alibaba veterans Benny Chen and "KK" Kshitij Karundia. In this instalment of Sino Indo Tekno, Benny reflects on the many benefits that the Indonesian entrepreneur can realize in working closely with his/her counterparts in China. The founding team of BAce played key roles in higher profile Alibaba and Ant Financial investments such as Lazada and Tokopedia in Indonesia, and PayTM and Zomato in India. BAce invests in an Indonesian start-up if the partners can easily connect that company to longer term learning relationships with: 1) Alibaba and Ant Financial themselves (China's absolute leaders in e-commerce and fintech, respectively), and 2) some of the hundreds of investee companies within Ant and Alibaba's broader ecosystems. How do companies in China scale? What are best practices in product development? What are the most powerful ways to leverage big data? Benny profiled a number of activities that his team has arranged for BAce Indonesian portfolio companies such as Printerous and RoomMe. Learning visits to meet industry peers in China helped answer questions such as those above, while focused workshops on Chinese COVID mitigation techniques offered these companies valuable coping mechanisms for the pandemic. In his concluding remarks, Benny suggests that continuous improvements in Indonesian infrastructure and expansion in digital payments & logistics are key to driving further online growth.

On this episode we have House Supply boss Benny Bace, along with Stanley Kubrix, and Vince Vini. Last half hour by Surfmyster, Tio Ruben, and The Brands.

This episode delves into how Ghanaian based startup, BACE Group, uses state of the art technology to tackle the problem of identity theft in Africa. Fan mail and feedback: hello@builtin.africa For ad placements: ads@builtin.africa Credits: Underneath the World by Mid-Air Machine www.freemusicarchive.org Additional sound effects from www.zapsplat.com

In this week’s episode: the show must not go on—NBAA cancels its annual convention due to Covid-19, and AIN senior editor Kerry Lynch has all the details; editor in chief Matt Thurber discusses Boeing’s long road to get the 737 Max back in service; Kerry also explains what Bombardier’s global environmental declaration for the Global 7500 really means; London-based editor Charles Alcock outlines the plans for a virtual Farnborough Airshow this month, and he also highlights Airbus’s testing of autonomous flight technology on an A350 widebody airliner; and Wichita-based editor Jerry Siebenmark covers OSHA’s proposed $13,000 fine against Textron Aviation due to a manufacturing plant accident in December.

In this week’s episode, senior editor Curt Epstein discusses what NBAA-BACE, the U.S. business aviation show slated for October 6 to 8 in Orlando, would look like if it is indeed held, news editor Chad Trautvetter shares highlights of traffic data that shows a promising recovery for business aviation, Washington, D.C. editor Kerry Lynch talks about a new FAA proposal for pilot record-keeping that has caught the ire of corporate flight departments, editor in chief Matt Thurber gives an overview of accident reports on the May Pakistan International Airlines A320 crash and September 2018 crash of a Falcon 50, and senior editor Charles Alcock compares the different ways Lufthansa and Qantas are trying to emerge intact from the Covid-19 pandemic.

Isaac and Ricky talk about the role that discipline took in Ricky changing his health, finances, and his music.

We can always find new ways to take care of ourselves. Tiffany takes you through a new concept to help you nourish your body and mind. Daily Mantra: I nourish my body and mind. Learn more about the BACE self-care routine: https://bit.ly/2WFHcJZ SPECIAL OFFER: Get Shine Premium for 50% off at shinetext.com/anxiety

In this podcast Karen expands on why the 144,000 are approaching BACE camp, the need for it and expands on the BRIDGE that we are preparing to enter.www.truth-codes.comwww.releasingeden.comSupport the show (https://www.paypal.com/cgi-bin/webscr?cmd=_s-xclick&hosted_button_id=CUXQ6NLKGARCS&source=url)

NBAA Business Aviation Convention & Exhibition (NBAA-BACE) and Bombardier Safety Standdown 2019. Strange ideas to make airlines greener, commuter planes to avoid road traffic, Southwest maintenance records, therapy animals, Hawaiian Airlines, 777X BBJ.

Listen to the top five general aviation news updates for the week of October 28, 2019, in under five minutes! In this episode, find out what went down in Las Vegas at NBAA-BACE this year! Also, find out how one aerospace company plans to get out of the red by the end of this year and learn more about what AOPA and the FAA are doing to save this California airport. 

what it takes to make a looner bace.

what you need for a mars bace

With so much to do in only three days, learn how you can maximize your attendee experience at NBAA's flagship Business Aviation Convention & Exhibition (NBAA-BACE).

With so much to do in only three days, learn how you can maximize your attendee experience at NBAA’s flagship Business Aviation Convention & Exhibition (NBAA-BACE).

Healthcare Direkt är programmet där vi pratar om veckans händelser inom life science. I veckans avsnitt gästas vi av Irlabs vd Nicholas Waters som berättar om deras studieresultat för läkemedelskandidaten IRL790 vid behandling av ofrivilliga rörelser (dyskinesier) hos patienter med Parkinsons sjukdom i fas 2a. Resultaten visade på förbättringar i två av tre mätmetoder, där det primära effektmåttet dock inte uppvisade någon skillnad jämfört med placebo. Nyhetsuppdateringen tar upp Novartis forskning inom Alzheimers sjukdom där det schweiziska läkemedelsbolaget avbryter forskningen av en läkemedelskandidat inom klassen Bace-hämmare. I säsongens sista avsnitt innan sommaruppehållet gör vi en tillbakablick på kursutvecklingen inom sektorn och går igenom kursraketer och sänken. Aktier/bolag som nämns i programmet: A1M Pharma, Alzinova, Ambea, Astra Zeneca, Attendo, Bioarctic, Cellavision, Cyxone, Emotra, Episurf, Getinge, Hansa Biopharma, IBT, Initiator Pharma, Irlab, Karolinska Development, Novartis, Nuevolution, Oasmia, Peptonic, Saniona, Sectra och Stenocare. Ser du hellre programmet i videoformat? Välkommen att besöka vår kanal på youtube.com/playdirekt

Bringing our IEP Faithful this weeks episode of the Indecent Exposure Podcast with Chicago guitarist and Co-Owner/Producer of the BACE record lable, Jeff Swanson. Jeff's new record "Case-Fitter" is now available on all streaming platforms. More on Jeff at: www.jeffswansonmusic.com

Christian Bace, former Digital Marketing Executive for the History Press Publishers and English Heritage, talks about how marketing heritage via social media has changed, the 1066/2016 E.H. Twitter campaign, making animated videos about Hadrian's Wall, rubbing shoulders with David Attenborough, and his (misplaced) hopes for Man Utd.

Автрорская программа Николая Крупатина "Откуда Ноты Растут" на Matryoshka Radio выходит в эфир с 2015 года. Программа о музыке и музыкантах. ПерваяЭфирнаяРусскоязычнаяРазвлекательнаярадиостанцияв ЛондонеMatryoshkaRadioоснованав2015году. Внастоящеевремярадиостанцияостаётсяполностьюнезависимой коммерческойрадиостанцией,невходящейниводиниз радиохолдингов.ВрамкахреализациипроектаMatryoshkaRadio Global,кромеэфиравнаиболееперспективномцифровомэфирном форматеDABвЛондоне,в2018-мгодурадиостанцияорганизовала эфирноевещаниевгородахGlasgow(Scotland)иMarbella(Spain). Открывающий джингл "Откуда Ноты Растут" История создания композиции Don't Turn Around Ace Of Bace - Don't Turn Around Tina Turner - Don't Turn Around Закрывающий джингл "Откуда Ноты Растут"

Автрорская программа Николая Крупатина "Откуда Ноты Растут" на Matryoshka Radio выходит в эфир с 2015 года. Программа о музыке и музыкантах. ПерваяЭфирнаяРусскоязычнаяРазвлекательнаярадиостанцияв ЛондонеMatryoshkaRadioоснованав2015году. Внастоящеевремярадиостанцияостаётсяполностьюнезависимой коммерческойрадиостанцией,невходящейниводиниз радиохолдингов.ВрамкахреализациипроектаMatryoshkaRadio Global,кромеэфиравнаиболееперспективномцифровомэфирном форматеDABвЛондоне,в2018-мгодурадиостанцияорганизовала эфирноевещаниевгородахGlasgow(Scotland)иMarbella(Spain). Открывающий джингл "Откуда Ноты Растут" История создания композиции Don't Turn Around Ace Of Bace - Don't Turn Around Tina Turner - Don't Turn Around Закрывающий джингл "Откуда Ноты Растут"

Anxiety and stress is affecting more and more Irish adults these days and we’re finding it harder to cope with what life throws at us. Did you know that 80% of adults in Ireland have been affected by anxiety, with almost half (44%) reporting that their mental wellbeing is of real concern to them? While fitness and exercise helps greatly, we also need to look after our emotional being as well. Sarah O'Neill chartered psychologist and MD of Spectrum Mental Health joins me on this week’s show to discuss dealing with the growing anxiety in our work and personal lives. “Stress can be helpful in the short term to help us respond to challenges,” Sarah explains. “But long term it can become chronic and debilitating.” Sarah recommends checking in with your BACE on a regular basis which is: Body – how is your physical health? Achievement – celebrate your achievements Connection – reach out to people, we are all social animals Enjoyment – don’t forget to enjoy life as well! Plus, she has some great tips and practical exercises if you find your mind and body going through the triggers of stress and anxiety, including how to avoid avoidance, talking it out, and developing a greater awareness and understanding. Let me know how you get on by emailing me at realhealth@independent.ie or via Twitter and Instagram @KarlHenryPT. For more from the show visit: https://www.independent.ie/podcasts/the-real-health-podcast/ The Real Health podcast is in association with Laya Healthcare.

Listen to our host Brent Fishlock and guest Brian Laird, our Senior Sales Manager in the U.S. talk about what TrianingPort can offer to a U.S. flight department.

Join us on Sunday September 23rd for a Product Spotlight show featuring two natural skincare lines.  The creators of these lines will be on the show to discuss and share information on their product brands.  Joining us will be Natasha Fortune (Bace Skincare) and Priya Maharaj (MAHA Skin Therepy). You dont want to miss it. Tell a friend, we are LIVE at 9pm EDT/6pm PDT.

Though the 2018 NBAA Business Aviation Convention & Exhibition (NBAA-BACE) is still months away from arriving in Orlando this October, an exciting program of education sessions is already in the works.

Though the 2018 NBAA Business Aviation Convention & Exhibition (NBAA-BACE) is still months away from arriving in Orlando this October, an exciting program of education sessions is already in the works.

General aviation groups are working to get out a message of opposition to ATC, and that effort continued to be in focus at NBAA’s Business … Continued

NBAA-BACE attendees wanting to learn about the latest technology for use in the industry should attend an education session titled, “Technology-Driven Trends in Business Aviation,” … Continued

A recent study from NEXA Advisors shows that America’s best companies rely on business aviation to succeed. The study found that S&P 500 companies using … Continued

In today's podcast, we look as influence operations in the UK and in Europe: the former emanate from Russia, the latter from Turkey. Third-party social media apps increase your attack surface. Petya ransomware is stolen and improved by rival crooks. Google purges bad apps from the Play Store. Patch Tuesday notes. A convicted leaker offers some unexpected wisdom for prospective whistleblowers. Lawyers can't figure out the GDPR. US said ready to indict four for the Yahoo! breaches. Emily Wilson from Terbium Labs discusses the effects of high profile breaches on Dark Web markets. Justin Harvey from Accenture Security wonder if private sector attribution is dead. And we bid a respectful farewell to Becky Bace, one of our industry's thought leaders.

At its annual convention, NBAA is offering three education sessions on the policies and regulations surrounding unmanned aircraft systems (UAS), including a session on protecting … Continued

Careers in Business Aviation Day is an annual highlight of the NBAA Business Aviation Convention & Exhibition (NBAA-BACE), and this year is no exception. Held … Continued

DKR Serial Killers Radio - are delighted to be able to bring you their first ever globally broadcasted radio show! Our 130th show brings you immense guest mix by Ideal Clubworld Radio resident - G-BACE... Check it out! Schedule: www.revolutionradio.ru (Wednesdays 20:00 GMT) www.urbancityradio.org (Wednesdays 21:00 GMT) www.realdanceradio.nl (Thursdays 21:00 GMT) www.wherestheculture.fm (Thursdays 23:00 GMT) www.radio35.rs (Friday 21:00 GMT) www.cuebase-fm.de (Saturdays 23:00 GMT) https://www.facebook.com/DKRSerialK1llersPodcasts https://www.mixcloud.com/SerialKillersRadio/ https://hearthis.at/dkrserialkillers

DKR Serial Killers Radio - are delighted to be able to bring you their first ever globally broadcasted radio show! Our 130th show brings you immense guest mix by Ideal Clubworld Radio resident - G-BACE... Check it out! Schedule: www.revolutionradio.ru (Wednesdays 20:00 GMT) www.urbancityradio.org (Wednesdays 21:00 GMT) www.realdanceradio.nl (Thursdays 21:00 GMT) www.wherestheculture.fm (Thursdays 23:00 GMT) www.radio35.rs (Friday 21:00 GMT) www.cuebase-fm.de (Saturdays 23:00 GMT) https://www.facebook.com/DKRSerialK1llersPodcasts https://www.mixcloud.com/SerialKillersRadio/ https://hearthis.at/dkrserialkillers

The Walking Dead and Sex Criminals... two great books, two very different sensibilities. This week Under the Comic Covers blends the two for a delicious pairing of stress and wtf?. We also talk about Skottie Young's new book, I Hate Fairyland... a fun murderous romp through a magical and adorable, yet incredibly maddening, land of make believe. Chapters Intro   (0:00)     UtCC News of the Week   (3:11) The Walking Dead #147: Out In the Open   (12:44) The Walking Dead Mail  (37:19) Sex Criminals #13: Bace   (47:07) Sexy Mail   (1:19:56) Top of the Stack: I Hate Fairyland   (1:21:50) End   (1:32:24)  Any questions, comments, or bazookas capable of destroying, or at the very least seriously maiming, the moon can be sent to feedback@utccovers.com You can also leave us a voicemail at (678) 796-UTCC, that's (678) 796-8822 Download and subscribe to this podcast in iTunes here We can also be found on the Stitcher Radio app for both iPhone and Android users. Look for us on Facebook at facebook.com/underthecomiccovers Follow us on Twitter @UtCCovers  And visit our Tumblr page underthecomiccovers.com  Be sure to also check out the other great podcasts on the Podcastica Network.

SMASH BROZ RADIO BRING YOU A DJ WITH YOU HOST TONY HUSTLER. #SBRPODCAST STAY CONNECTED WITH US FB- www.facebook.com/Smash-BROZ-Radio/ Twitter- www.twitter.com/SmashBrozRadio IG- INSTAGRAM/@smashbrozradio Tumblr- www.tumblr.com/@smashbrozradio YOU CAN ALSO GET OUR OLD MIX'S ON http://www.mixcrate.com/smashbrozradio FOR ALL YOU ANDROID USERS GET OUR MIX ALSO HERE http://www.mixcloud.com/SMASHBROZRADIO/ TUNE IN ON SATURDAYS AFTERNOON AT 1P.M.- 5P.M. PST www.superradiomix.com USE APP TUNEIN ON YOUR SMART PHONE TUNE IN ON MONDAY NIGHTS AT 10P.M. RADIO KSCR USE APP RADIO 365 ON YOUR SMART PHONE IF YOU HAVE ANY QUESTIONS OR BOOKING INFO EMAIL US AT sbradio91@yahoo.com SUBSCRIBE TO OUR PODCAST ON itunes SEARCH SMASH BROZ RADIO AND GET A FREE MIX EVERY WEEK THANK YOU AND ENJOY. THIS WEEK IN THE MIX WE HAVE DJ BACE Tracklist: 1. Avicii, Nicky Romero, & Dubvision Vs. Hardwell & Makj Vs. Merzo - I Could Be The Countdown (BACE Mashup) 2. Hardwell & Joey Dale - Arcadia (Thomas Newson Remix) 3. KSHMR - Leviathan (Original Mix) 4. Calvin Harris, Bassanova Vs. Martin Garrix & Moti - Blame The Virus (BACE Edit) 5. Cobra Effect - Bring The Voice (Original Mix) 6. Fedde Le Grand, Holl & Rush Vs Martin Garrix, Dimitri Vegas & Like Mike Vs. Kura & Halfway House - Where Blackmail Tremor's (BACE Mashup) 7. Halfway House - The Hammer (Extended Mix) 8. Martin Garrix - Proxy Bonkers (Nio Mashup) 9. Dada Life Vs MakJ & M35 - Everything is Go (Dada Life Mashup) (BACE Remash) 10. Quintino & FTampa - Slammer (Original Mix) 11. Bassjackers - Savior (Original Mix) 12. Hardwell, Laidback Luke, & Sven Kirchoff Vs. Gregori Klossman & Wahlsted - Dynamo On (BACE Edit) 13. Duck Sauce, Skrillex, Milo & Otis, & Ape Drums Vs Bottai - Parachute NRG (BACE Edit) 14. Calvin Harris - CUBA (Original Mix) 15. Patrick Hagenaar - Come Closer (Halfway House Remix) 16. Style of Eye Ft. Sirena - Louder (Botnek's Weirder Remix) 17. Heatbeat Vs. Halfway House - Bloody Martyr (BACE Mashup) 18. Dimibo - Shangri La (Original Mix) 19. Carlin & Fil - Departure (Extended Mix) 20. Cosmic Gate Ft. Jonathan Mendelson - All My Life (Extended Mix)

Obwohl seit der erstmaligen Beschreibung der Alzheimer-Erkrankung vor über 100 Jahren eine Vielzahl der ursächlichen histopathologischen Veränderungen und der beteiligten molekularen Mechanismen erforscht werden konnte, ist noch unklar, welche Faktoren die Spaltung des ß-Amyloid Vorläuferproteins (APP) beeinflussen und zu der pathologischen ß-Amyloid (Aß) Bildung und Aggregation führen. In zahlreichen Studien ergaben sich Hinweise, dass Cholesterin einen wichtigen Modulator der Alzheimer-Erkrankung darstellt. Zusammen mit Sphingolipiden bildet Cholesterin laterale Membrandomänen, sogenannte Lipid Rafts, die bei der Bildung der ß-Amyloid Plaques entscheidend beteiligt sein könnten. In der vorliegenden Arbeit wurde die Struktur dieser Domänen spezifisch verändert. Durch Transfektion mit dem Scavenger Rezeptor Klasse B Typ I (SR-BI) der die selektive Cholesterin- und Phospholipidaufnahme in die Zelle erhöht, wurden neue Lipid Rafts generiert und bestehende Domänen vergrößert. SR-BI induzierte eine Abnahme des von der α-Sekretase gespaltenen APP, sowie eine Zunahme des von der ß-Sekretase gespaltenen APP. Gleichzeitig kam es zu einem Anstieg der Menge des Aß-Peptids. Somit wurde gezeigt, dass ein Anstieg der Cholesterin-reichen Membrandomänen zu einer Abnahme der α-Sekretase Spaltung, einer Erhöhung der ß-Sekretase Spaltung und einer Zunahme der pathologischen ß-Amyloid Bildung führt. Während APP in Wildtyp-Zellen nahezu ausschließlich in DSM lokalisiert war, kam es durch die SR-BI Expression zu einer Translokation in DRM, die weitgehend Lipid Rafts repräsentieren. In den DRM konnte BACE damit mit APP interagieren. Um das subzelluläre Kompartiment zu identifizieren, an dem die APP-Spaltung stattfinden könnte, wurde mit Hilfe der Konfokalen Laserscanmikroskopie die intrazelluläre Verteilung von APP und BACE vor und nach SR-BI Expression untersucht. Nach SR-BI Transfektion war die Kolokalisation von APP und BACE in der Umgebung der Zellmembran deutlich verstärkt. Zusammen mit früheren Arbeiten lassen diese Ergebnisse vermuten, dass die verstärkte APP-Prozessierung durch Induktion Cholesterin-reicher Domänen vorwiegend submembranös (Early Endosomes) und auf der Ebene der Plasmamembran stattfindet. Ob eine medikamentöse oder diätetische Cholesterin-Reduzierung, die den Lipid Raft Anteil der Zelle senkt und somit die Interaktion von APP mit BACE verhindert, als Therapiemöglichkeit für die Alzheimer-Erkrankung in Frage kommt, bedarf noch weiterer intensiver Forschung.

Die Alzheimer-Krankheit (AD), die häufigste Form der Demenz, manifestiert sich klinisch meist ab dem 65. Lebensjahr mit langsam progredienten Gedächtnis-, Orientierungs- und Aufmerksamkeitsstörungen. Neuropathologische Korrelate sind die Amyloid-Plaques, die hauptsächlich aus extrazellulären Aggregaten des β-Amyloid-Proteins (Aβ) zusammengesetzt sind, und intrazelluläre neurofibrilläre Bündel, die aus Aggregaten des mikrotubulus-assoziierten Proteins Tau bestehen. Der „Auslöser“ der Alzheimer-Krankheit ist das β-Amyloid-Protein (Amyloid-Kaskaden-Hypothese), welches durch proteolytische Prozessierung von βAPP (β-Amyloid-Vorläufer-Protein) entsteht. Dies geschieht, indem zuerst BACE-1 (β-site APP cleaving enzyme 1) und anschließend der γ-Sekretase-Komplex βAPP schneiden. Menschen mit Down-Syndrom (DS), welches die häufigste autosomale Chromosomenaberration darstellt, entwickeln bereits ab einem Alter von 40 Jahren die typischen neuropathologischen Kennzeichen der Alzheimer-Krankheit und zeigen mit einem Durchschnittsalter von 56 Jahren die klinischen Symptome der Demenz. Die Gründe für das frühe Auftreten der Amyloid-Plaques sind noch nicht vollständig geklärt. Das Gen für βAPP befindet sich auf dem Chromosom 21, welches im DS dreifach vorhanden ist, und wird daher mit der frühen Plaque-Pathologie im Down-Syndrom in Zusammenhang gebracht. BACE-1 konnte durch Überexpressions- und Knock-out-Experimente eindeutig als alleinige β-Sekretase identifiziert werden. In Gehirnen von Alzheimer-Demenz-Patienten konnten im Vergleich zu Kontrollgehirnen erhöhte BACE-1-Proteinmengen und BACE-1-Aktivitäten nachgewiesen werden. Es war deshalb interessant zu untersuchen, ob auch im Gehirn von Down-Syndrom-Patienten die BACE-1-Proteinexpression erhöht ist. Durch eine Hochregulation von BACE-1 im Down-Syndrom könnte vermehrt βAPP prozessiert und somit Aβ gebildet werden. Daher war es das Ziel der vorliegenden Arbeit die Expression von BACE-1 in Gehirnen (Temporal- und Frontallappen) von DS-Patienten im Vergleich zu Kontrollgehirnen zu analysieren. In der Western-Blot-Analyse der Gewebeproben konnte gezeigt werden, dass die BACE-1-Proteinmengen im Down-Syndrom im Vergleich zu den Kontrollen (K) 1,4-fach erhöht waren. Die Proteinexpressionen von βAPP zeigten sich im DS im Vergleich zu den Kontrollen 1,4-fach erhöht. Diese Ergebnisse erzielten keine Signifikanz, zeigten aber deutliche Trends im Expressionsverhalten. Dies könnte auf die Anzahl der untersuchten Gehirne (Temporal- und Frontallappen je 3 DS, 4 AD und 5 K), Qualitätsmängel der Gehirnproben oder einer ungleichen Verteilung der Proteinexpression im Gewebe zurückzuführen sein. Es ist daher notwendig mehr Gehirne zu untersuchen. Zudem wäre es interessant in Gehirnschnitten das Verteilungsmuster der BACE-1-Expression im DS genauer zu studieren. Die Ergebnisse deuten jedoch auf eine Hochregulation von BACE-1 im DS-Gehirn und somit auf eine Beteiligung der Protease an der Plaquepathologie des Down-Syndroms hin. BACE-1 scheint also sowohl in der Pathogenese der Alzheimer-Demenz als auch in der des Down-Syndroms eine zentrale Rolle einzunehmen. Daher ist es sehr interessant die Regulation von BACE-1 weiter zu analysieren. Da in p25-überexprimierenden Mäusen erhöhte BACE-1-Proteinexpressionen gezeigt werden konnten, vermutete man eine Beteiligung von p25 an der Regulation der β-Sekretase. p25, das im Gehirn der AD-Patienten vermehrt gebildet wird und aus der Proteolyse von p35 entsteht, bindet und aktiviert die Kinase cdk5. cdk5 phosphoryliert unter anderem das Tau-Protein und wird daher mit der Bildung der neurofibrillären Bündel in Zusammenhang gebracht. Durch die Hochregulation von BACE-1 könnte p25 in der Pathogenese der Alzheimer-Erkrankung eine neue Bedeutung zugeschrieben werden. Zur Analyse der p25 induzierten Veränderungen in den Neuronen wurden humane Neuroblastomazellen mit einem induzierbaren p25-Expressionsvektor, Sp25-Zellen, verwendet. In diesen p25-überexprimierenden Zellen konnten sowohl in der Western-Blot-Analyse als auch in der BACE-1-Aktivitätsmessung erhöhte BACE-1-Proteinexpressionen bzw. BACE-1-Aktivitäten gezeigt werden. Die Northern-Blot-Analyse der Sp25-Zellen ergab erhöhte BACE-1-mRNA-Spiegel, die sich jedoch in einer für endogene BACE-1-mRNA untypische Größe detektieren ließen. p35, das membrangebundene Vorläufer-Protein von p25, war indes nicht in der Lage die BACE-1-Proteinexpression in humanen Neuroblastomazellen zu erhöhen. Die Ergebnisse der Sp25-Zellen konnten in p25-überexprimierenden murinen Neuroblastomazellen, Np25-Zellen, nicht reproduziert werden. Daher ist es notwendig, den p25-induzierten BACE-1-Regulationsmechanismus auf seine Reproduzierbarkeit, z.B. in weiteren In-vivo-Modellen, zu überprüfen.

Alzheimer-disease-associated beta-amyloid (A beta) is produced by sequential endoproteolysis of beta-amyloid protein precursor (beta APP): the extracellular portion is shed by cleavage in the juxtamembrane region by beta-amyloid-cleaving enzyme (BACE)/beta-secretase, after which it is cleaved by presenilin (PS)/gamma-secretase near the middle of the transmembrane domain. Thus, inhibition of either of the secretases reduces A beta generation and is a fundamental strategy for the development of drugs to prevent Alzheimer disease. However, it is not clear how small compounds reduce A beta production without inhibition of the secretases. Such compounds are expected to avoid some of the side effects of secretase inhibitors. Here, we report that destruxin E (Dx-E), a natural cyclic hexadepsipeptide, reduces A beta generation without affecting BACE or PS/gamma-secretase activity. In agreement with this, Dx-E did not inhibit Notch signaling. We found that Dx-E decreases colocalization of BACE1 and beta APP, which reduces beta-cleavage of beta APP. Therefore, the data demonstrate that Dx-E represents a novel A beta-reducing process which could have fewer side effects than secretase inhibitors. Copyright (C) 2009 S. Karger AG, Basel

The deposition amyloid β peptide in the brains of patients is a hallmark of Alzheimer’s disease and is thought to play a major pathogenetic role in the development of the demential symptoms of this severe illness. The amyloid β peptide is generated from the β-amyloid precursor protein (APP) by cleavage of the “β-site APP-cleaving enzyme” (BACE) followed by cleavage of the "gamma-secretase”. Whereas it has recently been discovered that the gamma-secretase is a multi-protein complex, it has not yet been investigated whether under native conditions, BACE functions in association with other proteins. The present work thus studied BACE by means of blue native gel electrophoresis and found that native BACE has a molecular weight of 140 kDa, whereas BACE under denaturing conditions has a molecular weight of 70 kDa which is only half of its native mass. Co-immunoprecipitation experiments with differently tagged full-length BACE constructs subsequently showed that this higher molecular weight species of BACE corresponds to a BACE homodimer. In contrast, a BACE ectodomain, lacking the C-terminus and the transmembrane domain, is a monomer. A consecutive domain analysis revealed that both the C-terminus and the transmembrane domain of BACE are dispensable for dimerization. In line with this, it could be shown that the ectodomain of BACE can dimerize if it is attached to the membrane by a GPI anchor. In terms of the cellular localization of the dimerization process, it could furthermore be demonstrated that retention of BACE in the ER by addition of a KKXX-motif does not prevent dimerization. This suggests that dimerization can occur prior to full maturation of BACE which takes place in the Golgi apparatus. In addition, kinetic analyses of the purified native BACE dimer revealed a higher affinity and turnover rate for an APP-like substrate in comparison to the monomeric soluble BACE ectodomain. This suggests a putative function of dimerization in improving enzymatic efficiency. The implication of these findings for our understanding of the Amyloid-β synthesis as well as for a putatively alternative therapeutic strategy are discussed.

Die Inhibition der b-Sekretase stellt derzeit einen vielversprechenden Ansatz zur Therapie der Alzheimer Krankheit dar. Der Hauptanteil der b-Sekretase Aktivität ist auf BACE-1, eine neuartige membrangebundene Typ I Aspartylprotease, zurückzuführen. Um gezielt spezifische und wirksame Inhibitoren entwickeln zu können, ist es notwendig, die Eigenschaften und katalytischen Spezifitäten der Protease genauer zu verstehen. Da neben BACE-1 eine weitere hochgradig homologe Aspartylprotease, BACE-2, bekannt ist, ist es für die Suche nach Inhibitoren ferner von Bedeutung, charakteristische Unterschiede zwischen den beiden Enzymen zu kennen, um mögliche Kreuzreaktionen der Inhibitoren minimieren zu können. Ziel dieser Arbeit war es deshalb, die beiden Enzyme bezüglich ihrer posttranslationalen Modifikationen und insbesondere ihrer katalytischen Spezifitäten vergleichend zu analysieren. Als Modell für die durchgeführten Experimente dienten HEK293 Zellen, mit exogener Expression der beiden Proteasen, sowie dem Substrat bAPP. Beide Proteine werden in ähnlicher Weise durch die kovalente Bindung komplexer Kohlehydrateinheiten modifiziert. Matures BACE-1 besitzt im Vergleich zu BACE-2 eine eine längere Halbwertszeit. In vitro werden beide Enzyme durch CK1 an homologen Serinen in der zytoplasmatischen Domäne phosphoryliert. Während für BACE-2 bisher nicht schlüssig gezeigt werden konnte, dass auch in vivo eine Phosphorylierung erfolgt, wurde für BACE-1 S498 auch als Phosphorylierungsstelle in vivo bestätigt. Mittels Biotinylierung konnte demonstriert werden, dass beide BACE-Proteasen effizient an die Zelloberfläche transportiert werden. Im Gegensatz zu BACE-1, welches rasch in endosomale Kompartimente reinternalisiert wird und phosphorylierungsabhängig zurück zum TGN transportiert wird, wird BACE-2 entweder durch Spaltung der Ektodomäne in den extrazellulären Raum sezerniert, oder aber unmittelbar nach der Reinternalsierung ins Zellinnere in lysosomalen Kompartimenten abgebaut. Dieser Unterschied begründet vermutlich die unterschiedlichen Halbwertszeiten der beiden Proteine und erhöht gleichzeitig die Gesamtverweildauer von BACE-1 in endosomalen Kompartimenten, die aufgrund ihres pH-Wertes günstige Bedingungen für die proteolytische Aktivität des Enzyms schaffen. Hinsichtlich der katalytischen Spezifität bezüglich des membrangebundenen bAPP unterscheiden sich BACE-1 und BACE-2 grundlegend. Während BACE-1 die erwarteten b-Sekretase Spaltungen an Asp1 und Glu11 der Ab-Domäne katalysiert, spaltet BACE-2 vorzugsweise zwischen Phe19 und Phe20 der Ab-Domäne, wodurch Spaltprodukte entstehen, die denen der a-Sekretase Spaltung ähneln. Durch Koexpression der beiden Enzyme konnte gezeigt werden, dass BACE-2 die BACE-1 abhängige Prozessierung des Substrates direkt oder indirekt beeinflussen kann. Die Behandlung der entsprechenden Zelllinien mit BFA oder Monensin belegt, dass BACE-1 bereits in den frühen Kompartimenten des sekretorischen Prozessierungsweges proteolytisch aktiv sein kann, während BACE-2 auch nach exogener Expression keine Aktivität in diesen Kompartimenten zeigt. Mit Hilfe massenspektrometrischer Analysen wurde bewiesen, dass BACE-1 und BACE-2 entgegen bisheriger Annahmen nicht ausschließlich die proteolytische Spaltung membrangebundener bAPP Substrate katalysieren, sondern zudem Ab-Peptide, nach ihrer Freisetzung durch g-Sekretase, C-terminal verkürzen können. In vitro Versuche zeigen, dass BACE-1 selbst in der Lage ist, Ab 1-40 an Position 34 zu spalten und dieser Schnitt nicht wie bislang angenommen durch g-Sekretase katalysiert wird. Dieser Vorgang führt in vivo zu einer Reduktion der amyloidogenen Ab 1-40/42 Peptide. Da sich der Nachweis des Ab 1-34 Peptides mittels konservativer Proteinanalytik schwierig gestaltet, erklärt sich, warum in Zelllinien mit exogener BACE-1 Expression keine merkliche Steigerung der Ab-Sezernierung bzw. teilweise sogar eine Reduktion detektierbar war. Letztendlich bietet die Beobachtung, dass auch Peptide als Substrate für die BACE fungieren können, interessante Ansatzpunkte für die Suche nach neuen physiologischen Substraten und Inhibitoren. Die Analyse des subzellulären Transportes und die Charakterisierung, sowohl pro- als auch antiamyloidogener Enzymaktivitäten der beiden Proteasen BACE-1 und BACE-2 liefert neue Grundlagen für die Entwicklung therapeutischer Inhibitoren und für die Suche neuer Substrate.