Podcasts about aetiology

Types and grades of pelvic organ prolapse Aetiology of pelvic organ prolapse Current recommendations for surgical and non-surgical management of prolapse How to prevent recurrence after surgical treatment of pelvic organ prolapse? Role of hysterectomy in managing pelvic organ prolapse Host: Dr Terri Foran | Total Time: 33 mins Expert: Prof Christopher Maher, Urogynaecologist Register for our fortnightly FREE WEBCASTSEvery second Tuesday | 7:00pm-9:00pm AEST Click here to register for the next oneSee omnystudio.com/listener for privacy information.

In this episode of the Athletes Compass podcast, hosts Paul Warloski and Marjaana Rakai dive into the contentious issue of muscle cramps with sports science expert Dr. Paul Laursen. They explore two prevailing hypotheses: the common belief that cramps are due to electrolyte imbalances and dehydration, and the neuromuscular hypothesis which posits that cramps stem from unfamiliar tasks and neuromuscular fatigue. Through detailed explanations and personal anecdotes, the discussion reveals compelling evidence supporting the neuromuscular perspective, emphasizing the importance of context-specific training and preparation. Listeners are encouraged to rethink conventional wisdom and adopt more tailored training strategies to mitigate cramping.Key Episode TakeawaysMuscle cramps are more likely caused by neuromuscular issues than electrolyte imbalances.Lack of task familiarity and neuromuscular fatigue are primary contributors to cramps.Proper preparation and context-specific training are crucial in preventing cramps.Industry promotions of electrolyte solutions lack robust scientific support.Acute cramp relief can be achieved through stretching to reset neuromuscular communication.Post-exercise nutrition should include a balance of proteins and electrolytes.Timothy Noakes - Waterlogged: The Serious Problem of Overhydration in Endurance SportsEffect of Personalized Sodium Replacement on Fluid and Sodium Balance and Thermophysiological Strain During and After Ultraendurance Running in the Heat in: International Journal of Sports Physiology and Performance Volume 19 Issue 2 (2023)Aetiology of skeletal muscle 'cramps' during exercise: a novel hypothesis - PubMed

Poddagogen gästas av Fred Johansson som delar med sig av färsk forskning om studenters psykiska ohälsa. Vi pratar om covideffekter, sömn, prokrastinering, sexuella trakasserier och sexuellt våld som olika delorsaker till den ökade psykisk ohälsan hos studenter och unga vuxna. Avhandlingen heter: Aspects of the Aetiology of Mental Health Problems among University Students.

About Today's Guest:Marty Kendall is an engineer revolutionizing nutrition using a data-driven, nutrient-first approach. His interest in nutrition began over twenty years ago to help his wife Monica gain control of her Type 1 Diabetes.  Since then, he's developed a systematized approach to nutrition that has helped thousands of people lose weight, reverse insulin resistance, and reclaim their health.  This led him to explore the concept of nutrient density and its effect on blood sugar stabilization and overall health. Marty's background in engineering has allowed him to approach nutrition from a quantitative and data-driven perspective, focusing on providing the body with the right nutrients in the most efficient way possible. He shares his learnings at OptimisingNutrition.com and runs Data-Driven Fasting and the Macros and Micros masterclasses to guide people on their journey of nutritional optimisation.  Episode Summary:In this episode, Aimee interviews Marty Kendall about his journey into the world of nutrient density. Marty explains the concept of the personal fat threshold and how it relates to type 2 diabetes and metabolic disease, emphasizing the importance of prioritizing nutrient-dense foods and how they can satisfy our cravings and promote satiety. He also discusses how the food industry influences our food choices and the need to be mindful of processed foods. Throughout the conversation, Marty challenges the conventional beliefs and superstitions surrounding nutrition and encourages listeners to focus on providing their bodies with the nutrients they need to thrive.Key Takeaways:Nutrient density is key: Prioritizing foods that are rich in essential nutrients can help satisfy our cravings and promote satiety.The personal fat threshold: Exceeding our personal fat threshold can lead to metabolic diseases like type 2 diabetes, as excess energy backs up into our bloodstream and vital organs.Energy balance and nutrient density: It's not just about eating fewer calories; it's about providing our bodies with the right nutrients in the right amounts.Resources:Photography by: Dai Ross Photography Podcast Cover Art: Lilly Kate Creative Blasphemous Nutrition on SubstackWork with Aimee"Ultra Processed People" by Chris Van Tucken: BookSimpson, S J, and D Raubenheimer. “Obesity: the protein leverage hypothesis.” Obesity reviews : an official journal of the International Association for the Study of Obesity. vol. 6,2 (2005): 133-42. doi:10.1111/j.1467-789X.2005.00178.xTaylor R, Barnes AC, Hollingsworth KG, Irvine KM, Solovyova AS, Clark L, Kelly T, Martin-Ruiz C, Romeres D, Koulman A, Meek CM, Jenkins B, Cobelli C, Holman RR. Aetiology of Type 2 diabetes in people with a 'normal' body mass index: testing the personal fat threshold hypothesis. Clin Sci (Lond). 2023 Aug 31;137(16):1333-1346. doi: 10.1042/CS20230586. PMID: 37593846; PMCID: PMC10472166.Nutrient Optimiser CommunityNutrient Optimiser Website

In this week's episode, Jonathan is joined by Geraldine Dawson, Director of the Duke Center for Autism and Brain Development, and the Duke Autism Clinic, Durham, North Carolina, USA. In the first of a two-part episode, the pair discuss autism screening, the characteristics of autism in infancy, and the benefits of early intervention in social interactions. Use the following timestamps to navigate the content in this episode:  (00:00)-Introduction (02:15)-What led Dawson to an academic career in psychology and autism (05:09)-How do we characterise being ‘on the spectrum'? (09:29)-Aetiology of autism: genetic and environmental factors (13:20)-Dawson's early, groundbreaking research into autism symptoms in infancy (17:17)-Why is the incidence of autism increasing? (19:45)-The Early Start Denver Model: early autism interventions (23:24)-Time Magazine's medical breakthrough of 2012

หลังจากจบตอนที่ 1 ของหัวข้อนี้ น้องๆได้ความเข้าใจเรื่องความเกี่ยวพันระหว่างดัชนีมวลกายกับเบาหวานประเภทที่ 2 รับทราบว่าการได้รับพลังงานล้นเกิน ในคนที่มีระดับเพดานกักเก็บไขมันใต้ชั้นผิวหนังต่ำ (Personal Fat Threshold) อาจเป็นต้นกำเนิดของเบาหวานประเภทที่ 2 ในตอนจบนี้พี่ปุ๋มจะนำเอางานวิจัยที่สำคัญของ Prof.Roy Taylor ศาสตราจารย์ด้านอายุรศาสตร์และเมตาบอลิสม เป็น Director of Magnetic Resonance Center อยู่ที่ University of Newcastle สหราชอาณาจักร มาสรุปให้น้องๆฟังกัน เขาเป็นผู้ตั้งสมมุติฐานของ Personal Fat Threshold ว่าเป็นต้นกำเนิด (Aetiology) ของเบาหวานประเภทที่ 2 และสมมุติฐานของ Twin Cycle Hypothesis พี่ปุ๋มจะนำงานวิจัยที่สำคัญของ Prof.Roy Taylor มาสรุปให้น้องๆได้ฟังกันนะคะ โดยเฉพาะงานวิจัยฉบับล่าสุดที่เพิ่งตีพิมพ์สดๆร้อนๆซึ่งเป็นการทดสอบสมมุติฐาน Personal Fat Threshold ของเขาที่สำคัญ ลิงค์อ้างอิงงานวิจัย 7 ฉบับ Cause of Insulin Resistance: The Personal Fat Threshold (ตอนจบ) 1. Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168743/pdf/125_2011_Article_2204.pdf 2. Very Low-Calorie Diet and 6 Months of Weight Stability in Type 2 Diabetes: Pathophysiological Changes in Responders and Nonresponders https://diabetesjournals.org/care/article/39/5/808/30678/Very-Low-Calorie-Diet-and-6-Months-of-Weight 3. Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial https://dacemirror.sci-hub.st/journal-article/54f864d9e758e0d7a4c02cc7d439d6c1/lean2017.pdf?download=true 4. Remission of Human Type 2 Diabetes Requires Decrease in Liver and Pancreas Fat Content but Is Dependent upon Capacity for β Cell Recovery https://www.cell.com/action/showPdf?pii=S1550-4131%2818%2930446-7 5. Aetiology of Type 2 diabetes in people with a ‘normal' body mass index: testing the personal fat threshold hypothesis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10472166/pdf/cs-137-cs20230586.pdf 6. From chronic overnutrition to insulin resistance: The role of fat-storing capacity and inflammation https://zero.sci-hub.st/1544/b69228f84ca76b1cfc1cd1bb4159b906/lionetti2009.pdf?download=true 7. Pathogenesis of type 2 diabetes: tracing the reverse route from cure to cause https://link.springer.com/content/pdf/10.1007/s00125-008-1116-7.pdf?pdf=button

In this episode of Better Thinking, Nesh Nikolic speaks with Ilan Dar-Nimrod about the effects of perceived genetic aetiology for various phenomena. Dr. Ilan Dar-Nimrod is an Associate Professor at the School of Psychology, University of Sydney. Ilan has completed his BA with a double major at Haifa University and his MA and PhD (social psychology) at the University of British Columbia. Ilan's main research focus is social cognition – the manner in which our social world affects our cognition. Within this focus, he concentrates on understanding how a deeply rooted psychological mechanism – Psychological Essentialism – is involved in categorising people into groups, leading to a host of effects on people's beliefs, emotions, and behaviours. In addition to this main line of research, he maintains ongoing research foci on a number of topics, such as existential social and clinical psychology, sexuality, gender psychology, and the psychology of religion. His research on this topic appeared in myriad of prestigious journals, such as Science, Psychological Bulletin, Nature Human Behaviour, and Genetics in Medicine. Episode link at https://neshnikolic.com/podcast/ilan-dar-nimrodSee omnystudio.com/listener for privacy information.

Dr. Jill Sylvester reviews the article, “Aetiology and Incidence of Sudden Cardiac Arrest and Death in Young Competitive Athletes in the USA: A 4-Year Prospective Study,” which was originally published in the British Journal of Sports Medicine in November 2021. Dr. Jeremy Schroeder serves as moderator. Dr. Sylvester is a member of the AMSSM Top Articles Subcommittee, and this episode is part of an ongoing mini journal club series highlighting each of the Top Articles in Sports Medicine from 2021, as selected for the 2022 AMSSM Annual Meeting in Austin, TX. Aetiology and Incidence of Sudden Cardiac Arrest and Death in Young Competitive Athletes in the USA: A 4-Year Prospective Study DOI: 10.1136/bjsports-2020-102666

On this episode, Jonathan is joined by Noel Morgan, Professor of Endocrine Pharmacology, University of Exeter, UK. The pair discuss Morgan's extensive research in diabetes, including his research on islet biology and signalling mechanisms regulating pro-inflammatory and anti-inflammatory processes in β-cells in Type 1 diabetes. They further discuss areas of research that excite and frustrate him, how we can change beliefs and behaviours associated with diabetes, and the future of diabetes research.   Use the following timestamps to navigate the topics discussed in this episode:   (00:00)-Introduction (02:00)-Morgan's origin story (03:30)-Experiences from Nashville, USA (06:00)-Islet biology (08:00)-Insulin secretion control (12:25)-Aetiology and differences between Type 1 and Type 2 diabetes (15:10)-The largest collection of rare pancreas samples in the world (17:50)-Different ‘types' of Type 1 diabetes (20:15)-Pro-insulin (22:35)-To B or not to B? (24:35)-Rituximab (26:00)-Dorothy Hodgkin Lecture (28:00)-The global obesity epidemic and changing behaviour (31:45)-The war on obesity (33:40)-A longer, unhealthy life? (34:45)-Exciting topics and immunotherapy (36:50)-Three wishes

In this episode with Dr Noe Mkumbuzi, we explored how most research and literature is based on the caucasian male. We then went through the key points of her TEDx talk around how many socio-economic and cultural factors are missed in the research and in one-to-one consults. Noe ended this episode with some wonderful pearls and tips on how to have real and genuine conversations around these topics with our patients.Noe is a Sports Physiotherapist and Exercise Scientist, she has a special interest in African women and girls in sport as well as those from other low and middle-income settings. She recently completed her PhD with University of Cape Town on Aetiology of pain in chronic midportion Achilles tendinopathy. Noe's TED Talk - https://www.youtube.com/watch?v=l3TXULxJT6cIf you like the podcast, it would mean the world if you're happy to leave us a rating or a review. It really helps!Our host is Michael Rizk from Physio Network and iMoveU: https://cutt.ly/ojJEMZs 

Support the Delingpod's existence by joining James' Locals: https://jamesdelingpole.locals.com/   Dr Michael Mew qualified in the 1993 as a dentist at the Royal London Hospital. After several years in general practice, community dentistry and facial surgery, he entered the renowned Orthodontic programme at Aarhus University in Denmark, qualifying as a specialist dentist in 2004. He is particularly interested in the cause of crooked teeth and the Aetiology of Malocclusion, he feels that when the profession understands so little, it is best to start at the bottom and work up.   Freedom isn't free - James needs your support to continue creating The Delingpod. There are many ways you can show your support to James: Join the James Delingpole Community as a paid supporter at: jamesdelingpole.locals.com Support James monthly at: subscribestar.com/jamesdelingpole Support James' Writing at: substack.com/jamesdelingpole www.delingpoleworld.com Buy James a Coffee at: buymeacoffee.com/jamesdelingpole   Find full episodes of The Delingpod for free (and leave a 5-star rating) on: Apple Podcasts: https://podcasts.apple.com/gb/podcast/the-delingpod-the-james-delingpole-podcast/id1449753062 Spotify: https://open.spotify.com/show/7bdfnyRzzeQsAZQ6OT9e7G?si=a21dc71c7a144f48 Podbean: delingpole.podbean.com Odysee: https://odysee.com/@JamesDelingpoleChannel:0 Rumble: https://rumble.com/user/JamesDelingpole BitChute: https://www.bitchute.com/channel/Zxu5yMwNWTbs/ YouTube: https://www.youtube.com/c/TheJamesDelingpoleChannel   Follow James on Social Media: Twitter: twitter.com/jamesdelingpole Instagram: instagram.com/delingpodclips GETTR: gettr.com/jamesdelingpole Telegram: https://t.me/+dAx_7JX7WQlwYzVk  

Dr. Edward Bass+ more Aetiology: the cause, set of causes, or manner of causation of a disease or condition. Pathology: the science of the causes and effects of diseases, pathological features considered collectively; the typical behavior of a disease Recognizing Anxiety in Dogs Preventing Anxiety in Dogs About Dr Edward: The Healing Vet Dr Edward Bassingthwaite is a registered veterinarian doctor and holistic vet, with a big heart for animals. He offers a range of veterinary services including home visits, Whole Energy Body Balance for animals, behavioural and training assistance, and standard medical diagnosis and treatments. His practice covers the regions of Melbourne, Frankston, and the Mornington Peninsula. Learn More bhsales.vpweb.com --- Send in a voice message: https://anchor.fm/bhsales/message

References Dr. Guerra lecture notes J AM Coll Cardiology Basic Trans Science.2019. (4) 3: 385-400 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message Support this podcast: https://anchor.fm/dr-daniel-j-guerra/support

Over the next two episodes, the Good GP interviews Clinical Professor Peter Silbert on the topic of peripheral neuropathy. In this episode, Dr Silbert provides clear insights into the causes, presentations and investigations of peripheral neuropathies, a common GP condition that affects 25% of people over the age of 70. Dr Peter Silbert is a Neurologist at Perth Neurophysiology and has completed advanced training in Neurophysiology. He is a Clinical Professor of Neurology (University of Western Australia) and is on the board of the Neurological Council of Western Australia. Dr Silbert was also the interviewee in our highest rating episode to date, episode 55 on migraine management and treatment.

Dr Michael Mew qualified in the 1993 as a dentist at the Royal London Hospital. After several years in general practice, community dentistry and facial surgery, he entered the renowned Orthodontic programme at Aarhus University in Denmark, qualifying as a specialist dentist in 2004. He is particularly interested in the cause of crooked teeth and the Aetiology of Malocclusion, he feels that when the profession understands so little, it is best to start at the bottom and work up.Find his website at https://orthodontichealth.co.uk/about/Find his YouTube channel at https://www.youtube.com/c/Orthotropics/***TIMESTAMPS***0:00 - Intro2:45 - Mike Mew's background and controversial idea: mewing7:40 - Why do we have crooked teeth?13:20 - James Nestor and the book, Breathe, and hypothesis on jaw structure and mouths18:00 - Orthodontics community strong dislike for Dr. Mike Mew's concept; my issues with my orthodontist experience31:00 - Dr. John Mew and the current state of mewing and what needs to be done to continue the exposure 34:00 - How to Mew 54:00 - Will newer generations want to continue this change in dentistry? Why are people working jobs they hate for purely material gain?59:00 - Why Mewing isn't a revolutionary idea and how this goes back to manners 1:04:00 - Issues with trying to get a breakthrough with this theory; the setbacks and difficulty with attempting to expose these ideas1:12:00 - Jawzercise and Chiseled, not a gimmick! 1:18:00 - Sleep Apnea and killing 20% of people in their 60's1:24:08 - Outro~YouTube EPISODES:https://www.youtube.com/channel/UCyLKzv5fKxGmVQg3cMJJzyQ/videos~Song provided by: Ayush Garg

Episode #6 In this episode, Nadia "turns the table" on Megan and we find out how she and Dr. Jason Fung started IDM, when The Fasting Method program went online, and what the future holds for TFM. Megan shares her own health journey from diabetes, PCOS, fatty liver, and an almost 80-pound weight loss as Dr. Fung's first IDM "patient" in 2012. The Aetiology of Obesity lecture series by Dr Jason Fung: Part 1: https://youtu.be/N0Lw0rtRq3s Part 2: https://youtu.be/_bFc3qVOBJA Part 3: https://youtu.be/O45Z8gcSA3I Part 4: https://youtu.be/irQNg0-OSBg Part 5: https://youtu.be/YTc8kS5mDa8 Part 6: https://youtu.be/UPO52VaQXyY Learn More About Our Community: https://www.thefastingmethod.com Join our FREE Facebook Group: https://bit.ly/TFMNetwork Watch Us On YouTube: https://bit.ly/TFMYouTube Follow Us on Instagram: @fastingmethod

Einkaufen, Kino, Party oder Arbeit: es gibt Momente in unserem Alltag, in denen wir ohne Hund unterwegs sein wollen oder müssen. Damit das Alleinebleiben stressfrei gelingt ist es wichtig, dass es richtig geübt wird. In dieser Folge reden Madita & Kate über die Voraussetzungen für den Start des Trainings, wie wir bei unterschiedlichen Kandidaten vorgehen sollten und warum Abschieds- und Begrüßungsrituale so wichtig für die Bindung und das Training sind.Bücher & Studien:Schöberl, I., 2012: Effects of owner-dog relationship and owner personality on cortisol modulation in human-dog relationships; Siniscalchi, M. et al., 2013: like owner, like dog. In: PLoSOne8 (10). Rehn, T. et al., 2014: Dogs' endocrine and behavioural responses at reunion are affected by how the human initiates contact. Physiology & Behavior 124: 45-53; Rehn, T., L. Keeling (2011): The effect of time left alone at home on dog welfare. Animal Behaviour, Science 129: 129-135 A., Casey et al, 2002: Aetiology of separation– related behaviour in domestic dogs. In: Vet Rec 151, 43 – 46. Gansloßer & Kitchenham, 2015: Beziehung, Erziehung, Bindung, S. 115ff. (Kosmos). Unsere allgemeinen Datenschutzrichtlinien finden Sie unter https://art19.com/privacy. Die Datenschutzrichtlinien für Kalifornien sind unter https://art19.com/privacy#do-not-sell-my-info abrufbar. See acast.com/privacy for privacy and opt-out information.

Auch wenn wir und unser Hund ein eher beschauliches Dasein als „Landeier“ leben – irgendwann kommt der Zeitpunkt, an dem auch wir mal Bus oder Bahn nutzen müssen. Das kann viel Stress für den Hund bedeuten, ein vorbereitendes Training macht also für alle sehr viel Sinn. Aber wie bringe ich meinem Welpen oder Tierschutzhund das Nutzen der öffentlichen Verkehrsmittel so bei, dass er zum entspannten Reisebegleiter werden kann? Madita und Kate gehen auf unterschiedliche Lebensphasen, Biographien und Persönlichkeiten von Hunden ein und klären auch über Regelungen auf, die für Fernzüge der Deutschen Bahn gelten. Also: ran ans Üben und dann: eine gute, entspannte Reise.Bücher & Studien:Kitchenham, 2019: Hunde (Kosmos) - mit Tipps für ein erfolgreiches Bahntraining A., Casey et al, 2002: Aetiology of separation– related behaviour in domestic dogs. In: Vet Rec 151, 43 – 46. Appleby, M. et al, 2008: Relationship between aggressive and avoidance behaviour by dogs and their experience in the first six months of life.Unsere allgemeinen Datenschutzrichtlinien finden Sie unter https://art19.com/privacy. Die Datenschutzrichtlinien für Kalifornien sind unter https://art19.com/privacy#do-not-sell-my-info abrufbar. See acast.com/privacy for privacy and opt-out information.

Today's Guest is Dr Mike Mew, Dr Michael Mew qualified in as a dentist at the Royal London Hospital. After several years in general practice, community dentistry, and facial surgery, he entered the renowned Orthodontic program, qualifying as a specialist dentist. He is particularly interested in the cause of crooked teeth and the Aetiology of Malocclusion, he feels that when the profession understands so little, it is best to start at the bottom and work up.Connect with Dr Mike Mew:Website: https://orthodontichealth.co.uk/Instagram: https://www.instagram.com/mr.mewing/?hl=enYoutube: https://www.youtube.com/user/OrthotropicsAbout TAKE A DEEP BREATH: Welcome to TAKE A DEEP BREATH (TADB), here you will find a huge variety of Breathing Exercises for Health, Relaxation & Motivation. Here you will also find our dedicated breathing podcast (Breathcast), where you can watch interviews with the worlds top breathing experts https://youtube.com/playlist?list=PLoVrvn2_-QGbNwagnvQEEfVbCay3682De Safety Information: Do not practice this breathwork during pregnancy, or if you are epileptic. People with cardiovascular issues, or any other serious health conditions, should always consult a medical professional before starting breathwork. These breathing exercises are a guide only, you should always listen to your own body and not push yourself, if you feel unwell STOP. Never practice breathing exercises before or during diving, driving, swimming, taking a bath, or in any other circumstance where the loss of consciousness could result in bodily harm. Deep breathing may cause tingling sensations, a ringing in the ears, and/or light-headedness. These are normal responses and are no cause for alarm. If you faint, however, you have gone too far and should take it more slowly next time. Top Books on Breathing and Breathwork:✅ Wim Hofs new book "The Wim Hof Method" https://geni.us/EBJR✅ James Nestor's Book 'Breath The New Science of a Lost Art' here: https://geni.us/c1CK✅ Anders Ollson Book: "Conscious Breathing" here: https://geni.us/9mjmz7✅ Belisa Vranich "Breathing For Warriors" here: https://geni.us/J7QjBc✅ Belisa Vranich "Breathe" here: https://geni.us/G5q8BeDisclaimer The information provided in this video is provided for informational purposes only and is NOT to be used or relied on for any treatment purposes. All information provided by TAKE A DEEP BREATH is of a general nature, only for educational/entertainment purposes. No information is to be taken as medical or health advice. Follow this breathing exercise at your own risk. TAKE A DEEP BREATH or Mike Maher is not responsible for any losses, liabilities, injuries or damages resulting from any and all claims as a result of your reliance on the information contained in this video. There is the possibility of physical injury. If you engage in this exercise or exercise program, you agree that you do so at your own risk, are voluntarily participating in these activities, assume all risk of injury to yourself. We use affiliate links which means if you buy something, we'll receive a commission, we appreciate the support you give us and we hope to keep adding value to you.

In this episode, we explore what endometriosis means to different people and what we currently know about what causes the disease. From the perspective of someone living with endometriosis, Margarida Sardo shared with us how endometriosis has shaped who she is, and why knowing what causes endometriosis would have been very important to her throughout her journey with endometriosis. We delve deeper into some of the main theories of what we currently think causes endometriosis with Dr Martin Hirsch, consultant gynaecologist and endometriosis specialist surgeon at Oxford University Hospitals, and Dr Nicola Tempest, and endometriosis researchers and academic clinical lecturer at the University of Liverpool. We also get insight into what endometriosis looks like inside the body from a surgeon's perspective, and how researching endometriosis can help us better understand the disease itself, its causes and help us to diagnose and treat it more effectively, in the future. If you liked today's episode, please like, share and subscribe! This podcast was generously brought to you by the Nuffield Department of Women's and Reproductive Health, at the University of Oxford. We would like to thank Dr Nicola Tempest and Dr Martin Hirsch for sharing their research, clinical and surgical expertise in the field of endometriosis. Finally, thank you to Margarida Sardo for sharing with us what endometriosis means to her, as well as her science communication expertise throughout the podcast.  Contact Details: Dr Nicola Tempest: (Twitter) @Hapangama_lab Dr Martin Hirsch: (Twitter) @martinhirsch (Instagram) @endometriosis.surgeon.uk Margarida Sardo: (Twitter) @MargaridaSardo (Email) margaridasardo@me.com Additional Resources: Learn more about the theories discussed throughout the episode. Want to support endometriosis research aiming to better understand the underlying cause? Please consider donating to Wellbeing of Women. 

In this episode, Aswin Babu discusses key points from a recent case report published in EHJ – Case Reports.

In this episode, Stacey, Lisa & Ness talk about puppies, their upbringing, settling them into their new home and how to add a "protective layer" against separation anxiety. Lisa once again brings her monkey to the show and the Terminator also pays a visit. Link to the Bradshaw study, Aetiology of separation-related behaviour in domestic dogs - https://veterinaryrecord.bmj.com/content/151/2/43.short?fbclid=IwAR3jVq3qNGUzuOJTa-K5gRcQgX_VrZNmGeC1OKPUamM-BhWJC_TrCNQS59w

Today we are reporting on the 'FLIP device' and give you an update on the likely aetiology of achalasia.  There have been studies on 'motorised spiral enteroscopy'. Is a motor really a good thing inside the small bowel?  We are surprised to see a complete turnaround in the recommendations from Sheffield on how to diagnose Coeliac disease !  Sadly, surveillance in patients with MUTyH related polyposis doesn't seem to save lives.  Should we all start doing 'full thickness' colonic resections?  I urge caution!   Finally, there have been some good news and some bad news on the topic of emergency GI bleeding ... References: Savarino E. T Use of the Functional Lumen Imaging Probe.  American Journal of Gastroenterology 2020;115(11):1786-96 Campagna RAJ. Intraoperative assessment of oesophageal motility using FLIP during myotomy for achalasia.  Surgical Endoscopy 2020;34(6):2593-2600 Ikebuchi Y. microRNAs in biopsy samples of lower oesophageal sphincter muscle during peroral endoscopic myotomy for oesophageal achalasia.  Digestive Endoscopy. 2020;32(1):136-42 Ramchandani M. Diagnostic yield and therapeutic impact of novel motorized spiral enteroscopy in small-bowel disorders: a single-center, real-world experience from a tertiary care hospital.  Gastrointestinal Endoscopy.  2020 Jul 12. Beyna T. Total motorized spiral enteroscopy: first prospective clinical feasibility trial.  Gastrointestinal Endoscopy.  2020 Oct 31. Penny HA. Accuracy of a no-biopsy approach for the diagnosis of coeliac disease across different adult cohorts. Gut 2020 Nov 02. Guz-Mark A. High rates of serology testing for coeliac disease, and low rates of endoscopy in serologically positive children and adults in Israel: lessons from a large real-world database.  European Journal of Gastroenterology & Hepatology. 2020;32(3):329-34 Thomas LE.  Duodenal adenomas and cancer in MUTYH-associated polyposis: an international cohort study.  Gastroenterology.  2020 Oct 29. Patel R.  MUTYH-associated polyposis - colorectal phenotype and management.  Colorectal Disease 2020;22(10):1271-78 Yeh JH.  Long-term Outcomes of Primary Endoscopic Resection vs Surgery for T1 Colorectal Cancer: A Systematic Review and Meta-analysis.  Clinical Gastroenterology & Hepatology. 2020;18(12):2813-23 Boger P.  Endoscopic full thickness resection in the colo-rectum: outcomes from the UK Registry. European Journal of Gastroenterology & Hepatology.  2020 Oct 29. Zwager LW.  Endoscopic full-thickness resection (eFTR) of colorectal lesions: results from the Dutch colorectal eFTR registry.  Endoscopy. 2020;52(11):1014-23 Lee HS.  Comparison of conventional and modified endoscopic mucosal resection methods for the treatment of rectal neuroendocrine tumors.  Surgical Endoscopy.  2020 Oct 22. Kherad O. Systematic review with meta-analysis: limited benefits from early colonoscopy in acute lower gastrointestinal bleeding. [Review] Alimentary Pharmacology & Therapeutics. 52(5):774-88, 2020 09. Alzoubadi D. Outcomes from an international multicenter registry of patients with acute gastrointestinal bleeding undergoing endoscopic treatment with Hemospray.  Digestive Endoscopy. 2020;32(1):96-110

In this episode Tim Pilleri and Lance Reenstierna chat with old friend Professor Elizabeth Yardley of Birmingham City University where she is a professor of Criminology. We discuss her newest research paper titled "The Aetiology of Rejected Stalking: Towards an integrated theoretical framework".Follow Liz's social media: https://twitter.com/ProfLizYardley, https://twitter.com/crimebitespod Check out Liz Yardley's site at https://www.elizabethyardley.com/ And her podcast Crime Bites: https://www.stitcher.com/podcast/elizabeth-yardley/crime-bitesSign the Blue Ribbon petition! https://www.mauramurraymissing.org/petition.htmlCheck out the Murray family site: https://www.mauramurraymissing.org/Sign up for our Patreon page at https://www.patreon.com/crawlspacepodcast. Five bucks a month gets you access to new content every week.Check out the new Crawlspace Discussion Facebook group: https://www.facebook.com/groups/talkcrawlspace/Check out our entire network at http://crawlspace-media.com/Go to https://smile.amazon.com/ to connect your existing Amazon account to donate to PI's For the Missing.Follow Private Investigations For the Missinghttps://investigationsforthemissing.org/http://piftm.org/donatehttps://twitter.com/PIFortheMissinghttps://www.facebook.com/PIFortheMissing/https://www.instagram.com/investigationsforthemissing/Follow Missing Maura Murray:Twitter: https://twitter.com/MauraMurrayDocFB: https://www.facebook.com/MauraMurrayDoc/IG: https://www.instagram.com/missingmauramurray/Youtube: https://www.youtube.com/MissingMauraMurrayApple: https://podcasts.apple.com/us/podcast/missing-maura-murray/id1006974447Spotify: https://open.spotify.com/show/0yRXkJrZC85otfT7oXMcri

In this episode Tim Pilleri and Lance Reenstierna chat with old friend Professor Elizabeth Yardley of Birmingham City University where she is a professor of Criminology. We discuss her newest research paper titled "The Aetiology of Rejected Stalking: Towards an integrated theoretical framework". Follow Liz's social media: https://twitter.com/ProfLizYardley, https://twitter.com/crimebitespod Check out Liz Yardley's site at https://www.elizabethyardley.com/ And her podcast Crime Bites: https://www.stitcher.com/podcast/elizabeth-yardley/crime-bites Sign the Blue Ribbon petition! https://www.mauramurraymissing.org/petition.html Check out the Murray family site: https://www.mauramurraymissing.org/ Sign up for our Patreon page at https://www.patreon.com/crawlspacepodcast. Five bucks a month gets you access to new content every week. Check out the new Crawlspace Discussion Facebook group: https://www.facebook.com/groups/talkcrawlspace/ Check out our entire network at http://crawlspace-media.com/ Go to https://smile.amazon.com/ to connect your existing Amazon account to donate to PI's For the Missing. Follow Private Investigations For the Missing https://investigationsforthemissing.org/ http://piftm.org/donate https://twitter.com/PIFortheMissing https://www.facebook.com/PIFortheMissing/ https://www.instagram.com/investigationsforthemissing/ Follow Missing Maura Murray: Twitter: https://twitter.com/MauraMurrayDoc FB: https://www.facebook.com/MauraMurrayDoc/ IG: https://www.instagram.com/missingmauramurray/ Youtube: https://www.youtube.com/MissingMauraMurray Apple: https://podcasts.apple.com/us/podcast/missing-maura-murray/id1006974447 Spotify: https://open.spotify.com/show/0yRXkJrZC85otfT7oXMcri

With Marco Guazzi & Alessia Spina, University of Milano - Italy Link to paper  

I'm still thinking a lot about the COVID-19 pandemic. In this episode I turn away from some of the 'classical' ethical questions about the disease and talk more about how to understand it and form reasonable beliefs about the public health information that has been issued in response to it. To help me do this I will be talking to Katherine Furman. Katherine is a lecturer in philosophy at the University of Liverpool. Her research interests are at the intersection of Philosophy and Health Policy. She is interested in how laypeople understand issues of science, objectivity in the sciences and social sciences, and public trust in science. Her previous work has focused on the HIV/AIDs pandemic and the Ebola outbreak in West Africa in 2014-2015. We will be talking about the lessons we can draw from this work for how we think about the COVID-19 pandemic.You can download the episode here or listen below. You can also subscribe to the podcast on Apple, Stitcher and a range of other podcasting services (the RSS feed is here).Show NotesTopics discussed include: The history of explaining the causes of diseaseMono-causal theories of diseaseMulti-causal theories of diseaseLessons learned from the HIV/AIDs pandemicThe practical importance of understanding the causes of disease in the current pandemicIs there an ethics of belief?Do we have epistemic duties in relation to COVID-19?Is it reasonable to believe 'rumours' about the disease?Lessons learned from the 2014-2015 Ebola outbreakThe importance of values in the public understanding of scienceRelevant LinksKatherine's HomepageKatherine @ University of Liverpool"Mono-Causal and Multi-Causal Theories of Disease: How to Think Virally and Socially about the Aetiology of AIDS" by Katherine"Moral Responsibility, Culpable Ignorance, and Suppressed Disagreement" by Katherine"The international response to the Ebola outbreak has excluded Africans and their interests" by KatherineImperial College paper on COVID-19 scenariosOxford Paper on possible exposure levels to novel Coronavirus  #mc_embed_signup{background:#fff; clear:left; font:14px Helvetica,Arial,sans-serif; } /* Add your own MailChimp form style overrides in your site stylesheet or in this style block. We recommend moving this block and the preceding CSS link to the HEAD of your HTML file. */ Subscribe to the newsletter

What we see, hear, and feel as a child affects us later in life—and our brain is changed by childhood traumas. A leading Canadian psychiatrist is working to understand how childhood harm can impair brain development and affect mental health, in the hope of effective treatment. And we hear about an intervention which can improve educational outcomes for vulnerable children.

What we see, hear, and feel as a child affects us later in life—and our brain is changed by childhood traumas. A leading Canadian psychiatrist is working to understand how childhood harm can impair brain development and affect mental health, in the hope of effective treatment. And we hear about an intervention which can improve educational outcomes for vulnerable children.

This episode covers the basics of cleft lip and or palate aetiology, incidence and presention

EP80: Causes or Aetiology of Heart Failure

Greg Kirschen takes us through the treatment of postpartum depression and psychosis. feedback@obgyn.fm American Psychiatric Association. (2013). In Diagnostic and statistical manual of mental disorders (5th ed.). doi:10.1176/appi.books.9780890425596.744053 Tate G. 1830. “A Treatise on Hysteria.” London: S. Highley, 174 Fleet St & Webb St, Maze Pond, Borough. Smith TN. 1830. “Observations on hysteria.” The Boston Medical and Surgical Journal. 3(34): 540. Louden, I. 1988. Puerperal insanity in the 19thCentury. Journal of the Royal Society of Medicine. 81, p 76-79. Griffen W, Griffen D. 1829. Observations on Functional Disorders of the Spinal Cord, and Their Connexion with Hysterical, Nervous, and Other Diseases. Illustrated by Cases, Selected Chiefly from the Reports of the Pallas, Kenry, and Currah Dispensaries. London Medical and Physical Journal. 7(42) 477-489. Reid, J. 1848. Dr. Reid on Puerperal Insanity. Journal of Psychological and Medical Mental Pathology. 1(1): 128-151. Clark AC. 1887. Aetiology, Pathology, and Treatment of Puerperal Insanity. Journal of Mental Science. 33(142): 169-189. Donkin, AS. 1863. The Pathological Relation between Albuminuria and Puerperal Mania. Journal of Mental Science. 9(47): 401-405. Barkin V. 1929. Protein therapy in insanity of puerperal origin. British Medical Journal. 1(3549): 67. Earle P. 1854. Bloodletting in Mental Disorders. American Journal of Insanity. 10(4): 287-405. Mackenzie FW. 1851. Puerperal Insanity: Especially in Reference to Anaemia. London Journal of Medicine. 3(30): 504-521. Gordon HL. 1897. Sir James Young Simpson and Chloroform (1811-1870). Masters of Medicine. T. Fisher Unwin, for Great Britain and Longmans Green & Co. for the United States of America. Dunn, PM. 2002. Sir James Young Simpson (1811-1870) and obstetric anesthesia. Archives of Disease in Childhood-Fetal and Neonatal edition. 86(3): F207-F209. Koppanyi T, Dille JM, Linegar CR. 1936. Studies on Barbiturates: XVII. The Effect of Prolonged Chloroform Anesthesia on the Duration of Action of Barbiturates. The Journal of Pharmacology and Experimental Therapeutics. 119-127. Waters ATH. 1857. On the use of chloroform in the treatment of puerperal insanity. American Journal of Psychiatry. 13(4): 341-353. Ramachandran CT, Subramanyam N, Baker G, et al. 2011. Antidepressants: From MAOIs to SSRIs and more. Indian Journal of Psychiatry. 53(2): 180-182. Agin HV. 1963. Phenelzine in the treatment of depression. American Journal of Psychiatry. 119(12): 1173-1174. Blacker KH, Weinstein BJ, Ellman GL. 1962. Mother’s Milk and Chlorpromazine. 119(2): 178-179. Whalley LJ, Eagles JM, Bowler GMR, et al. 1987. Selective effects of ECT on hypothalamic-pituitary activity. Psychological Medicine. 17(2): 319-328. Williams RL, Barrera SE. 1950. Observations and opinions concerning complications and contraindications in electric convulsive therapy. Psychiatric Quarterly. 24(4): 800-809. Matthew JR, Constan E. 1964. Complications following ECT over a three year period in a state institution. American Journal of Psychiatry. 120(11)-1119-1120.  Sobel DE. 1960. Fetal Damage Due to ECT, Insulin Coma, Chlorpromazine, or Reserpine. AMA Archives of General Psychiatry. 2(6): 606-611. Langan RC, Goodbred AJ. 2016. Identification and Management of Peripartum Depression.American Family Physician. 93(10): 852-858.  Information from your family doctor: Postpartum depression. 2010. American Family Physician. 82(8): 939-940. Schiller CE, Schmidt PJ, Rubinow D. 2014. Allopregnanolone as a Mediator of Affective Switching in Reproductive Mood Disorders. Psychopharmacology. 231(17): 3557-3567. Bitran D, Hilvers RJ, Kellogg CK. 1991.Anxiolytic effects of 3α-hydroxy-5α[β]-pregnan-20-one:endogenous metabolites of progesterone that are active at the GABAA receptor. Brain Research. 561:157–161. Ottander U, Poromaa IS, Bjurulf E, et al. 2005. Allopregnanolone and pregnanolone are produced by the human corpus luteum. Molecular and Cellular Endocrinology. 239(1-2): 37-44. Meltzer-Brody S, Colquhoun H. Reisenberg R, et al. 2018. Brexanolone injection in post-partum depression: two multicentre, double-blind, randomised, placebo-controlled, phase 3 trials. The Lancet. 392(10152): 1058-1070.

Authentic Biochemistry's host, Dr Dan Guerra, continues his in depth cellular and molecular discussion of hepatocellular carcinoma (HCC) by introducing the non-universal yet a priori role for the glycolytic enzyme pyruvate kinase isoform M2 in paradigmatic tumor associated aerobic glycolysis. --- Support this podcast: https://anchor.fm/dr-daniel-j-guerra/support

Medical Student Gregory Kirschen takes us through the history of postpartum depression from hippocrates to present day.   References American Psychiatric Association. (2013). Cautionary statement for forensic use of DSM-5. In Diagnostic and statistical manual of mental disorders (5th ed.). doi:10.1176/appi.books.9780890425596.744053 King, H. 1998. Hippocrates’ Woman: Reading the Female Body in Ancient Greece. London: Routledge, 1st ed. https://doi.org/10.4324/9780203025994   Adams, H. (1984). Comprehensive Handbook of Psychopathology. New York: Springer Science + Business Media. P. 319. ISBN 97814615668.   Louden, I. 1988. Puerperal insanity in the 19th Century. Journal of the Royal Society of Medicine. 81, p 76-79.   Reid, J. 1848. Dr. Reid on Puerperal Insanity. Journal ofPsychological and Medical Mental Pathology. 1(1): 128-151.   Meltzer HY, Stahl SM. 1976. The dopamine hypothesis of schizophrenia: a review. Schizophrenia Bulletin. 2(1): 19-76.   Hirschfeld, R. 2000. History and evolution of the monoamine hypothesis of depression. The Journal of Clinical Psychiatry. 61(Suppl6), 4-6.   Winn, JM. 1855. On the Treatment of Puerperal Mania. Journal of Psychological and Medical Mental Pathology.. 8(30): 309-313.   MacLeod, MD. 1886. An address on puerperal insanity. British Medical Journal. 2(1336): 239-242.   Theriot, N. 1989. Diagnosing Unnatrual Motherhood: Nineteenth-century Physicians and ‘Puerperal Insanity.’ American Studies. 30(2): 69-88.   Henry, WO. 1907. To what extent can the gynecologist prevent and cure insanity in women? JAMA. XLVIII(12): 997-1002.   Boyd, R. 1870. Observations on puerperal insanity. Journal of Mental Science. 16(74): 153-165.   Clark, AC. 1887. Aetiology, Pathology, and Treatment of Puerperal Insanity. Journal of Mental Science. 33(142): 169-189.   Dunn, PM. 2002. Sir James Young Simpson (1811-1870) and obstetric anesthesia. Archies of Disease in Childhood-Fetal and Neonatal edition. 86(3): F207-F209.   Tuke, JB. 1867. Cases illustrataive of insanity of pregnancy, puerperal mania, and insanity of lactation. Edinburgh Medical Journal. 12(12): 1083-1101.   Donkin, AS. 1863. The Pathological Relation between Albuminuria and Puerperal Mania. Journal of Mental Science. 9(47): 401-405.   Miller GE, Cohen S, Ritchey AK. 2002. Chronic psychological stress and the regulation of pro-inflammatory cytokines: a glucocorticoid-resistance model. Health Psychology. 21(6): 531-541.   Cassidy-Bushrow AE, Peters RM, Johnson DA, et al. 2012. Association between depressive symptoms with inflammatory biomarkers among pregnant African-American women. Journal of Reproductive Immunology. 94(2): 202-209.   O’Mahony SM, Myint AM, van der Hove D, et al. 2006. Gestational stress leads to depressive-like behavioural and immunological changes in the rat. Neuroimmunomodulation. 13: 82-88.   Bamford, CB. 1934. An analytical review of a series of cases of insanity with pregnancy. Journal of Mental Science. 80(328): 58-63.   Ballantyne, JW. 1892. A series of thirteen cases of alleged maternal impression. Edinburgh Medical Journal. 37(11): 1025-1034.   Fisher GJ. 1870. Does Maternal Mental Influence Have any Constructive or Destructive Power in the Production of Malformations or Monstrosities at any Stage of Embryonic Development? American Journal of Insanity. XXVI(III): 241-295.   Pohlman AG. 1911. Maternal impression. Proceedings of the Indiana Academy of Science. 65-70.   Kundakovic M, Gudsnuk K, Herbstman JB, et al. 2015. DNA methylation of BNDF as a biomarker of early-life adversity.PNAS. 112(22): 6807-6813.   Boersma GJ., Lee RS, Cordner ZA, et al. 2014. Prenatal stress decreases Bdnf expression and increases methylation of Bdnf exon IV in rats. Epigenetics. 9(3): 437-447.   Zajicek-Farber ML. 2009. Postnatal depression and infant health practices among high-risk women. Journal of Child and Family Studies. 18:236.   Ban L, Gibson JE, West J, et al. 2010. Association between perinatal depression in mothers and the risk of childhood infections in offspring: a population-based cohort study. BMC Public Health. 10:799.   Ertel KA, Koenen KC, Rich-Edwards JW, et al. 2010. Antenatal and postpartum depressive symptoms are differentially associated with early childhood weight and adiposity. Paediatric and Perinatal Epidemiology. 24: 179-189.   Beck CT. 1998. The effects of postpartum depression on child development: A meta-analysis. Archives of Psychiatric Nursing. 12(1): 12-20.   Tuovinen S, Lahti-Pulkkinen M, Girchenko P, et al. 2018. Maternal depressive symptoms during and after pregnancy and child developmental milestones. Depression and Anxiety. 35(8): 732-741.   Foundeur M, Fixsen C, Tribel WA, et al. 1957. Postpartum Mental Illness: A Controlled Study. AMA Archives of Neurology and Psychiatry. 77(5): 503-512.  

Prof Lordick speaks with ecancertv at the Immuno-Oncology Hong Kong 2016 meeting about the classifications of gastric cancer, and how they might inform treatment. He outlines known biomarkers for patient subtyping, and considers when sequential treatment, anti-angiogenic therapy or combination therapies might be best used. Prof Lordick also introduces the 2019 Gastric Cancer Congress in Prague.

Rahul is temporarily back in our fair island nation, so here’s a cis-pacific podcast on cirrhosis. Part two will follow eventually, but like the course of this chronic disease, you probably know that the natural history of MedConversations can sometimes … Continue reading →

Human endogenous retroviruses are retroviral elements in the genome that were originally derived from exogenous retroviruses, which they closely resemble. Tove Christensen reviewed how they are associated with MS and may be involved in MS pathogenesis.

Herpes viruses have been implicated as one of the causal factors in MS onset but its role in disease progression is still uncertain. Tomas Bergström reviewed the current knowledge.

On today's show, we are joined by Dr. Jason Fung and Jimmy Moore, co-authors of The Complete Guide to Fasting: Heal Your Body Through Intermittent, Alternate-day, and Extended Fasting. We discuss Jimmy Moore’s current 21-day fast attempt, whether fasting is safe, fasting's track record, the benefits of fasting with regards to weight loss, diabetes, insulin levels, and longevity. Other topics include fasting for women, issues people may experience when fasting, and various methods of fasting. You'll also learn how Dr. Fung and Jimmy Moore implement fasting in their own lives. Then, we have have more food-for-thought dessert in our Moment of Paleo and After the Bell segments. Enjoy the show! Links for this episode:How to help support Latest in PaleoThis Episode's Homepage on latestinpaleo.comThe Complete Guide to Fasting: Heal Your Body Through Intermittent, Alternate-day, and Extended FastingBooks & AudiobooksFood & Product Shopping ListFacebook - Comment on this episode & post news linksIntensive Dietary Management BlogDr. Jason Fung (@drjasonfung) | TwitterJason Fung - YouTubeTherapeutic Fasting - Vail 2016 - YouTubeThe Aetiology of Obesity Part 4 of 6: The Fast Solution - YouTubeThe Official Website For Jimmy Moore's Livin' La Vida Low-CarbFacebook - Jimmy Moore's Livin' La Vida Low-CarbJimmy Moore (@livinlowcarbman) | TwitterJimmy Moore - YouTubeVisit PuraKai to shop for eco-friendly clothing and stand-up paddle boards. Be sure to use coupon code "latest in paleo" for 15% off all clothing purchases.

On this episode, I discuss my recent 5-day fast: how it went, what I learned, and whether I'll be doing it again. In the News & Views segment, we discuss a CNN article about fasting and longevity as well as a NY Times article that indicates intermittent fasting is becoming more widely accepted. You'll learn about a 450-lb man who did not eat food for over a year and reduced his body to a normal size. In the Moment of Paleo, I offer some ideas about when less is more. And After the Bell features a Dr. Jason Fung presentation about fasting as an important health tool. Enjoy the show! Links for this episode:This Episode's HomepageLatest in Paleo on Facebook - News hunters and gatherers post your links here.Full List of Recommended Books & AudiobooksEat, Fast & Live Longer HD - Video DailymotionOccasional fasting could help you live longer - CNN.comPeriodic fasting may lead to longer, healthier lives - AOLFasting Diets Are Gaining Acceptance - The New York TimesDietary restriction improves repopulation but impairs lymphoid differentiation capacity of hematopoietic stem cells in early agingHere's how occasional fasting could actually be good for you - ScienceAlertThe up- and downside of caloric restriction for aging and healthAGINGADVICE.ORGFasting - Wikipedia, the free encyclopediaDaniel Fast - Wikipedia, the free encyclopediaFasting Chart - Beliefnet.comUsing Fasting for Natural Healing | AllAboutFastingFasting: health benefits and risks - Medical News TodayA Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan: Cell MetabolismA History of Modern Research into Fasting, Starvation, and Inanition - SpringerMedically Supervised Water-only Fasting in the Treatment of HypertensionThe Fasting AdvantageHarpersMagazine Fasting - CloudupFasting: health risks - Live Well - NHS ChoicesWhat no one talks about when they extol the benefits of fasting - VoxFive day 'fasting' diet slows down ageing and may add years to life - TelegraphThe three-day fast: Day Four | Josh MitteldorfLifeboat Foundation Bios: Dr. Joshua MitteldorfBursts of fasting may be key to longevity and health - The Columbia Chronicle: Health & TechCould a 5-Day Fasting Diet Prolong Your Life?Effect of diet and exercise on serum insulin, IGF-I, and IGFBP-1 levels and growth of LNCaP cells in vitro (United States) - SpringerA year without food › Dr Karl's Great Moments In Science (ABC Science)The Ancient Secret of Weight LossIs Fasting an Effective Therapy for Weight Loss? - Weight LossThe Aetiology of Obesity Part 4 of 6: The Fast Solution - YouTubeVisit PuraKai to shop for eco-friendly clothing and stand-up paddle boards. Be sure to use coupon code "latest in paleo" for 15% off all clothing purchases.

Bovine neonatal pancytopenia (BNP) is a recently emerged alloimmune disease affecting neonatal calves and is strongly associated with the vaccination of dams with a specific inactivated BVDV (Bovine Viral Diarrhoea Virus) vaccine (PregSure® BVD, Pfizer Animal Health). The vaccine comprises a unique adjuvant based on nanoparticles and has been shown to be highly contaminated with cellular proteins of the vaccine producer cell line MDBK (Madin-Darby bovine kidney). The disease is induced by ingestion of colostral alloantibodies of certain PregSure® BVD-vaccinated dams. The hypothesis that BNP-associated alloantibodies might be directed against MHC class I has been proposed. Currently, there are published observations, which contradict this hypothesis and which suggest that the aetiopathogenesis of BNP has not been fully elucidated yet. The aims of this study were to gain more insights into selected factors and underlying mechanisms involved in BNP. The hypothesis of a genetic predisposition for clinical BNP had been proposed in a previous study, but the incidence and potential genetic predisposition for subclinical cases had not been investigated thoroughly before. Therefore, a well-defined cattle resource population was monitored for the incidence, vaccination-associated epidemiological factors and a possible genetic predisposition involved in subclinical BNP. Prominent immune responses to PregSure® BVD vaccination had been reported. This study characterised the immune response to a booster immunisation with PregSure® BVD to obtain insights into the structural and quantitative regulation of the blood transcriptome after vaccination by means of deep sequencing transcriptome analysis. Furthermore, this approach should facilitate insights into the composition of the vaccine. The previously proposed hypothesis of a genetic predisposition required for giving birth to clinical BNP-calves could be confirmed in this study. Our results suggest that a genetic predisposition is potentially also involved in subclinical BNP and additionally required for a significant decrease of thrombocytes and leucocytes in healthy calves without manifestation of clinical or subclinical BNP. In the monitored cattle resource population, the frequency of subclinical BNP did not exceed the frequency of clinical BNP-cases. Further vaccination-associated epidemiological factors, e.g. frequency of vaccination or time point of vaccination relative to parturition, could be excluded. Transcriptome analysis 14 days after booster vaccination with PregSure® BVD highlighted a very coordinated immune response to double-stranded (ds) RNA, although the inactivated vaccine was directed against a single-stranded (ss) RNA BVD virus. The source of the dsRNA is unknown and could have originated from the MDBK cell line, which would underline the contamination of the vaccine with host cells from vaccine production. Alternatively, a dsRNA analogue was potentially added to improve the efficacy of the vaccine. Finally, this study identified a cytokine-like gene, which was highly upregulated across all animals after booster vaccination. This gene has not been described before in any other species. It has to be evaluated if upregulation of this gene is specific for ruminant immune response and linked to PregSure® BVD vaccination. In conclusion, this study confirmed that a genetic predisposition of PregSure® BVD-vaccinated dams is required for producing BNP-colostrum. Therefore, prospective studies will have to consider genetically determined differential immune responses between BNP- and non-BNP-dams towards exogenous proteins combined with very potent adjuvants. Regarding the MHC class I hypothesis, published observations raise the question, if MHC class I should be considered as single causal agent for BNP-associated alloantibodies. This requires further research. Potential allogeneic effects of a whole panel of contaminating proteins contained in the vaccine still have to be validated.

Background Atopic diseases are a major burden of disease on a global scale. Regarding their aetiology, the early years of life are assumed to play a crucial role. In addition, there is growing evidence that elucidating the impact of cross-generational effects and epigenetic mechanisms such as DNA methylation can substantially widen the scientific knowledge of the occurrence and progression of these diseases. We are thus aiming at following the course of asthma, allergies, and potential risk factors for their occurrence across three generations by establishing a birth cohort in the offspring of an existing population-based cohort. Methods/Design 2051 young adults who have been recruited in 1995 for Phase II of the International Study of Asthma and Allergies in Childhood (ISAAC) and who have subsequently been followed-up by the Study on Occupational Allergy Risks (SOLAR) are asked bi-annually since 2009 if they conceived a child in the meantime. If parenthood is reported, parents are invited to enrol along with their children in the ACROSSOLAR cohort. Participation involves completing a questionnaire assessing general and health-related information about the course of the pregnancy and the first year of life of their children. Subsequently, the children are followed up until primary school age when asthma and allergies can be diagnosed reliably. In addition, DNA for epigenetic analysis will be collected and analysed. Longitudinal data analysis techniques will then be used to assess potential associations between early-life exposures and onset of childhood asthma and allergies taking into account epigenetics. Discussion Birth cohorts are especially suited to elucidate the impact of genetic predisposition, epigenetics, exposures during the first years of life, and gene-environment interactions on the occurrence and progression of asthma and allergies. By building upon an existing cohort, ACROSSOLAR offers a unique and cost-effective opportunity to investigate the aetiology of atopic disease in a prospective and cross-generational way.

Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler Guest: Tara C. Smith Tara Smith joins the TWiEBOVsters to discuss the Ebola virus outbreak in west Africa, spread of the disease to and within the US, transmission of the virus, and much more.   This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. The Department is presently looking to recruit any prospective graduate students to apply to our program by the December 1st deadline. Interested postdocs are also encouraged to contact faculty of interest. For more information about the Department, please visit www.mssm.edu/MIC. Links for this episode Science communications fellow at ASM Nation turns to science (New Yorker) CDC employees in West Africa (CDC) UN botched Ebola response (AP) Ebola czar (CNN) Ebola vaccine and budget cuts (HuffPo) Collins' ridiculous meme (NOT junk) How to quarantine against Ebola (Mukherjee) Ebola fear in Heartland (Tara Smith) Massive mutations in Ebola virus (PunditFact) Ebola airport screening (CDC) What is contact tracing? (video) (CDC) Inside MSF Ebola unit (YouTube) Ebola tech bulletin (DuPont) HAI controversies Letters read on TWiV 307 Weekly Science Picks Alan - Fall foliage mapKathy - Interviews with Peter Piot (one, two) and autobiographyVincent - The Ebola connection Listener Pick of the Week Brooke - N.B. Designs on EtsyVictor - SMBC Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Why are people mean to each other? Why can’t we all be friends? We in no way address those questions, but we do have some lists that any self-respecting young doctor should have readily accessible. Here’s the quizlet

Managing even uncomplicated HIV infection is a major undertaking. When compounded by nutritional compromise, as it so often is, it becomes many times more complex. When the two co-exist, mortality rises exponentially so awareness, prevention, early identification and aggressive management are essential.In this podcast, ADC's global health editor Nick Brown talks to Anna Rose, UCL, about her recent paper which examines both the HIV/ malnutrition relationship and the multiple spokes, social and medical required to tackle this global problem.Read the full paper here: http://goo.gl/ojCTxO

In a previous podcast you've seen how to to a laparoscopic nephrouterectomy for TCC. Now you can learn about transitional cell carcinoma itself. Susan Clayton discusses epidemiology, aetiology, presentation, investigation, treatment options and prognosis of TCC with Simon Williams. The podcast is mapped to learning outcomes from ISCP and covers all you need to know as a medical student and core surgical trainee (junior resident) about this common urological cancer. Listening to this is a few minutes well spent on the way to urology clinic or theatre where you might see a patient with TCC and be asked equations on it. Impress the consultant with your knowledge and structured presentation! Its also useful as a quick revision aid for more senior trainees, especially in the run up to an exam. Dr Susan Clayton is a core surgical trainee in the East Midlands School of Surgery UK, and Simon Williams is a Consultant Urological Surgeon at the Royal Derby Hospital, UK.

Jon Lund talks about the presentation, aetiology and treatment of anal fissure, explaining the aetiology with the help of diagrams in this video podcast. Get in touch though School of Surgery at podomatic.com and request topics you'd like to have available as podcasts

Late Onset Alzheimer's disease (LOAD) is the leading cause of dementia. Recent large genome-wide association studies (GWAS) identified the first strongly supported LOAD susceptibility genes since the discovery of the involvement of APOE in the early 1990s. We have now exploited these GWAS datasets to uncover key LOAD pathophysiological processes. We applied a recently developed tool for mining GWAS data for biologically meaningful information to a LOAD GWAS dataset. The principal findings were then tested in an independent GWAS dataset. We found a significant overrepresentation of association signals in pathways related to cholesterol metabolism and the immune response in both of the two largest genome-wide association studies for LOAD. Processes related to cholesterol metabolism and the innate immune response have previously been implicated by pathological and epidemiological studies of Alzheimer's disease, but it has been unclear whether those findings reflected primary aetiological events or consequences of the disease process. Our independent evidence from two large studies now demonstrates that these processes are aetiologically relevant, and suggests that they may be suitable targets for novel and existing therapeutic approaches.

Objectives: Downbeat nystagmus (DBN) is the most common form of acquired involuntary ocular oscillation overriding fixation. According to previous studies, the cause of DBN is unsolved in up to 44% of cases. We reviewed 117 patients to establish whether analysis of a large collective and improved diagnostic means would reduce the number of cases with ``idiopathic DBN'' and thus change the aetiological spectrum.Methods: The medical records of all patients diagnosed with DBN in our Neurological Dizziness Unit between 1992 and 2006 were reviewed. In the final analysis, only those with documented cranial MRI were included. Their workup comprised a detailed history, standardised neurological, neuro-otological and neuro-ophthalmological examination, and further laboratory tests.Results: In 62% (n = 72) of patients the aetiology was identified (``secondary DBN''), the most frequent causes being cerebellar degeneration (n = 23) and cerebellar ischaemia (n = 10). In 38% (n = 45), no cause was found (``idiopathic DBN''). A major finding was the high comorbidity of both idiopathic and secondary DBN with bilateral vestibulopathy (36%) and the association with polyneuropathy and cerebellar ataxia even without cerebellar pathology on MRI.Conclusions: Idiopathic DBN remains common despite improved diagnostic techniques. Our findings allow the classification of ``idiopathic DBN'' into three subgroups: ``pure'' DBN (n = 17); ``cerebellar'' DBN (ie, DBN plus further cerebellar signs in the absence of cerebellar pathology on MRI; n = 6); and a ``syndromatic'' form of DBN associated with at least two of the following: bilateral vestibulopathy, cerebellar signs and peripheral neuropathy (n = 16). The latter may be caused by multisystem neurodegeneration.

In this podcast, we have combined two recordings: the second recording follows on immediately from the first.

Aetiology, signs and prognosis of male cattle with urethral occlusion The objective of this prospective study was a detailed description of the clinical signs of cattle with urethral occlusion and to define prognostic indicators. Male cattle admitted to the clinic were included in the study if their history or initial clinical examination suggested urethral occlusion. A total of 126 cattle one month to two years old were enrolled. For the description of the clinical picture the relevant anamnestic information as well as the clinical and laboratory findings are described. Prognosis was evaluated on the basis of clinical, laboratory and post mortem findings, as well as on the subsequent course of survivors. The exact cause of the occlusion was determined by post mortem examination in non-survivors. Urethral occlusion can be diagnosed by physical examination. Failure to pass urine in animals with a distended urinary bladder or subcutaneous oedema or intraperitoneal urine accumulation are considered to be diagnostic. Not only the parameters of the special but also of the general physical examination turned out to be important in the evaluation of the stage of the disease and the detection of inflammatory processes. Initially a sawhorse stance, agitation and colic were prominent, whereas animals in the advanced stage became weak and recumbent; some of them did so after a transient period of apparent improvement of their general condition. For cattle with concomitant inflammatory processes an arched back with a distinctly depressed behaviour was significant. In addition these animals were mostly in a poor nutrional state and had a dull or shaggy haircoat. Among the findings of the special physical examination, inspection and/or palpation of the penis (evidence of a penis haematoma), the ventral abdomen (evidence of oedema), the abdomen (evidence of an intraperitoneal urine accumulation and/or peritonitis) and finally the evaluation of the umbilicus (evidence of ascending infections), bladder, and kidneys were found to be meaningful. Abdominocentesis was performed, if intraperitoneal urine accumulation and/or peritonitis was suspected. Depending on the age a rectal examination was often impossible. Deep palpation of the abdominal cavity couldn’t be performed in animals with a fully developed rumen, increased tension of the abdominal wall and those with ventral oedema or intraperitoneal urine accumulation. In these cases the diagnostic importance of ultrasonography in the examination of intraabdominal structures as well as the determination of increased inflammatory alteration of the intraabdominal fluid was evident. Among the laboratory findings, only azotaemia was significant, whereas other parameters didn’t show any consistent tendency with regard to the stage of disease or the involvement of inflammatory processes. A total 42 out of 60 animals with uncomplicated urethral occlusion were discharged. Out of 18 euthanized animals 11 were put to sleep because of extensive inflammatory alterations, five because micturition was not restored post operatively, and two because of other critical diseases. 41 of the patients showed intraperitoneal urine accumulation in varying extents with infections and accompanying irreparable inflammatory alterations present in 23 cases. Out of 18 cattle with non-infected intraperitoneal urine only seven could be cured, the others were put to sleep for other reasons. In two animals with slight oedema resorption took place within three days, whereas the massive infiltration of urine into the subcutis resulted in necrosis of the affected areas and was followed by gangrene in 13 cases. Except for two animals with an uracheal abscess and a bilateral pyelonephritis respectively all were discharged after an extended stay at the clinic. By contrast, four cattle with infected oedema developed cellulitis with distinct deterioration of their general condition and had to be destroyed. Six patients were put to sleep after the initial examination or during surgery. Therefore the further progression of the uric oedema couldn’t be evaluated. In five of these cases euthanasia was a consequence of urethral occlusion, in one case it was in consequence of another disease. Thus prognosis is mainly influenced by duration of illness as well as the involvement of inflammatory processes. Animals at the early stage of the disease, but also those with uric oedema in case of uncontaminated urine have a favourable prognosis. Prognosis is doubtful in animals with peritoneal accumulation of uninfected urine. It is nearly hopeless in the case of infiltration of infected urine into the subcutis (cellulitis) or in the abdominal cavity (peritonitis). Therefore, the presence of inflammatory processes should be ruled out as much as possible before surgical intervention is considered.

'NNYz? was last seen back at #375, and he returns to Kahvi with a short but sweet seven track EP called 'Aetiology'. Highly detailed textures with glitchy beats, field recordings and IDM arps combined into simply named but exotic sounding tracks. Track of choice: 4am for deliciously sweeping eighths for emotive spine tingling nostalgia. '