Podcasts about plos med

In this episode of The Pilates Exchange, we dive into the power of social connections and how working out with others can transform your fitness journey. Whether it's exercising with a friend, loved one, or in a group class, social support plays a vital role in keeping you motivated, enhancing your mental health, and improving long-term results. This episode is part of our February theme: "Share the Love", where we celebrate the positive impact that community and relationships have on our physical and emotional well-being.Key Takeaways:Social Connections & Longevity: Studies show that strong social bonds reduce the risk of mortality by 50% and contribute to overall better health. The more social support you have, the healthier you are.Accountability & Motivation: Exercising with others increases the likelihood of sticking to your fitness routine. Social interaction improves mood, boosts motivation, and leads to better exercise adherence.Oxytocin and Motivation: When you work out with others, your body releases oxytocin, the "love hormone," which strengthens trust, reduces stress, and enhances bonding and motivation.Forming New Friendships: Group fitness provides a fantastic opportunity for adults to make new friends. It creates an environment where trust is built, and social anxiety is reduced, making it easier to connect with others.Join the Movement:Follow us for more fitness inspiration, research-backed wellness tips, and community-building strategies on our social media channels.Share your story: Tell us how fitness has helped you connect with others by tagging us in your posts and using our hashtag #PerfitlyYouResources & Studies Mentioned:Holt-Lunstad, J., Smith, T. B., & Layton, J. B. (2010). "Social Relationships and Mortality Risk: A Meta-analytic Review." PLoS Med.Buman, M. P., et al. (2010). "Exercise and Social Interaction: The Influence of Social Support on Physical Activity and Mental Health." Health Psychology.Dunbar, R. I. (2010). "Oxytocin and Social Bonding: The Role of Oxytocin in Supporting Relationships and Motivation." Psychological Bulletin.The Psychology of Group Fitness: Why It Works for Making Friends as Adults (Journal of Health Psychology)

We meet Paul Garner (prof. emerit. and one of the founding fathers of Cochrane) and Rebecca Kuehn (Cochrane infectious diseases) for a talk about evidence-based medicine, critical appraisal and all things related to how we interpret and find the "truth" within research.Resources:1.Ioannidis JP. Why most published research findings are false. PLoS Med. 2005;2(8):e124.2.Garner P, Taylor-Robinson D, Sachdev HS. DEVTA: results from the biggest clinical trial ever. Lancet. 2013;381(9876):1439-41.3.Gigerenzer G. Making sense of health statistics. Bull World Health Organ. 2009;87(8):567.4.https://www.badscience.net/2010/07/yeah-well-you-can-prove-anything-with-science/5.de Souza DK, Thomas R, Bradley J, Leyrat C, Boakye DA, Okebe J. Ivermectin treatment in humans for reducing malaria transmission. Cochrane Database Syst Rev. 2021;6(6):CD013117.6.Foy BD, Alout H, Seaman JA, Rao S, Magalhaes T, Wade M, et al. Efficacy and risk of harms of repeat ivermectin mass drug administrations for control of malaria (RIMDAMAL): a cluster-randomised trial. Lancet. 2019;393(10180):1517-26.7.Popp M, Reis S, Schiesser S, Hausinger RI, Stegemann M, Metzendorf MI, et al. Ivermectin for preventing and treating COVID-19. Cochrane Database Syst Rev. 2022;6(6):CD015017.8.Hadinegoro SR, Arredondo-Garcia JL, Capeding MR, Deseda C, Chotpitayasunondh T, Dietze R, et al. Efficacy and Long-Term Safety of a Dengue Vaccine in Regions of Endemic Disease. N Engl J Med. 2015;373(13):1195-206.9.Dans AL, Dans LF, Lansang MAD, Silvestre MAA, Guyatt GH. Controversy and debate on dengue vaccine series-paper 1: review of a licensed dengue vaccine: inappropriate subgroup analyses and selective reporting may cause harm in mass vaccination programs. J Clin Epidemiol. 2018;95:137-9.10. Guyatt G, Oxman AD, Akl EA, Kunz R, Vist G, Brozek J, et al. GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables. J Clin Epidemiol. 2011;64(4):383-94.11. https://bestpractice.bmj.com/info/toolkit/learn-ebm/what-is-grade/12.Guyatt G, Vist G, Falck-Ytter Y, Kunz R, Magrini N, Schunemann H. An emerging consensus on grading recommendations? ACP J Club. 2006;144(1):A8-9. Hosted on Acast. See acast.com/privacy for more information.

Olá pessoal, sou André Burgos, e acabei de conduzir uma live incrível que vai revolucionar a forma como você encara a sua saúde. Discuti os perigos de 5 alimentos para diabéticos tipo 2, respondi a perguntas e compartilhei dicas valiosas para uma jornada mais saudável. Se você perdeu esse evento crucial, não se preocupe! Ouça agora ao episódio completo, mergulhe nas informações transformadoras e dê o primeiro passo para uma vida com saúde e qualidade. Fontes: - Malik VS, Popkin BM, Bray GA, Després JP, Willett WC, Hu FB. Sugar-sweetened beverages and risk of metabolic syndrome and type 2 diabetes: a meta-analysis. Diabetes Care. 2010;33(11):2477-83. - Barclay AW, Petocz P, McMillan-Price J, et al. Glycemic index, glycemic load, and chronic disease risk--a meta-analysis of observational studies. Am J Clin Nutr. 2008;87(3):627-37 - Jenkins DJ, Wolever TM, Taylor RH, et al. Glycemic index of foods: a physiological basis for carbohydrate exchange. Am J Clin Nutr. 1981;34(3):362-6 - Imamura F, Micha R, Wu JH, et al. Effects of saturated fat, polyunsaturated fat, monounsaturated fat, and carbohydrate on glucose-insulin homeostasis: a systematic review and meta-analysis of randomised controlled feeding trials. PLoS Med. 2016;13(7):e1002087 - Jenkins DJ, Wolever TM, Taylor RH, et al. Glycemic index of foods: a physiological basis for carbohydrate exchange. Am J Clin Nutr. 1981;34(3):362-6 :::::: Seja Membro e Receba Aulas e Conteúdos Exclusivos:::: https://www.youtube.com/channel/UCgeSWvdpxC7Ckc77h_xgmtg/join Entre em meu Canal do Telegram: https://t.me/canalandreburgos Inscreva-se em nosso canal http://goo.gl/Ot3z2raccc Saiba mais sobre o Método Protagonista em: https://escoladoprotagonista.com.br/oferta Programa Atletas LowCarb: https://atletaslowcarb.com.br/programa-alc/ Me siga no Instagram https://www.instagram.com/andreburgos/

MedLink Neurology Podcast is delighted to feature selected episodes from BrainWaves, courtesy of James E Siegler MD, its originator and host. BrainWaves is an academic audio podcast whose mission is to educate medical providers through clinical cases and topical reviews in neurology, medicine, and the humanities, and episodes originally aired from 2016 to 2021. Originally released: August 24, 2017 Fainting spells are surprisingly common--even among United States Marines. This week, we explore the mechanisms underlying loss of consciousness in your everyday patient. And your everyday soldier. Produced by James E Siegler. Music by Jason Shaw, Andy Cohen, Kai Engel, and Josh Woodward. BrainWaves' podcasts and online content are intended for medical education only and should not be used for clinical decision-making. REFERENCES Freeman R. Clinical practice. Neurogenic orthostatic hypotension. N Engl J Med 2008;358(6):615-24. PMID 18256396Grubb BP. Neurocardiogenic syncope and related disorders of orthostatic intolerance. Circulation 2005;111(22):2997-3006. PMID 15939833Sonnesyn H, Nilsen DW, Rongve A, et al. High prevalence of orthostatic hypotension in mild dementia. Dement Geriatr Cogn Disord 2009;28(4):307-13. PMID 19828952Wolters FJ, Mattace-Raso FU, Koudstaal PJ, Hofman A, Ikram MA; Heart Brain Connection Collaborative Research Group. Orthostatic hypotension and the long-term risk of dementia: a population-based study. PLoS Med 2016;13(10):e1002143. PMID 27727284  We believe that the principles expressed or implied in the podcast remain valid, but certain details may be superseded by evolving knowledge since the episode's original release date.

Sogovornica v dvajseti epizodi podkasta je Nuša Crnkovič, ki je opravila specializacijo iz forenzične psihologije na Univerzi v Maastrichtu na Nizozemskem. Njene delovne izkušnje so bogate in raznolike, od strogo varovanih psihiatričnih zaprtih oddelkov v Veliki Britaniji, preko varnih hiš Tajske pa vse do slovenskega NIJZ. Govorila sva o funkciji forenzičnega psihologa, o definicijah osebnostnih motenj in sociopatije ter o principih diagnostike in rehabilitacije posameznikov, ki bi jih morda označili za “psihopate”. Kaj sploh je definicija psihopata, kako se lahko vsak izmed nas izogne stigmi in v katerih filmskih uspešnicah so uspeli na najbolj prepričljiv način prikazati pravega psihopata, pa vam bo Nuša zaupala v pogovoru. Obenem pa tudi omenila, kako je v Republiki Sloveniji oblikovana mreža za psihološko pomoč, kam se lahko ob težavah zateče vsak od nas in zakaj je tako zelo pomembno, da v hudi stiski s tem ne odlašamo predolgo. Epizoda je nastala v sodelovanju z Varuhom zdravja, Vzajemno: https://www.vzajemna.si/varuj-zdravje/program-varuh-zdravja Nacionalni program duševnega zdravja MIRA je dostopen na: https://www.zadusevnozdravje.si/  Projekt Nisi Okej, Povej Naprej lahko spremljate na Instagramu (@nisiokejpovejnaprej) ali na: https://nisiokejpovejnaprej.si V pogovoru omenjava film No Country for Old Men, predvsem lik Antona Chigurha. Izsek pogovora na bencinski postaji lahko pogledate na: https://youtu.be/ZY0DG8rUnCA?si=uYxMGTU6dM9DBwHW Omenjava knjige: The Talented Mr. Ripley (Patricia Highsmith), Ko Telo Reče Ne (Gabor Maté), Ti Povem Zgodbo? (Jorge Bucay), Alkimist (Paulo Coehlo). Raziskava o nevarnosti socialne izolacije: Holt-Lunstad J et al. Social relationship and mortality risk: a meta-analytic review. PLoS Med, 2010.

Neste episódio falaremos sobre o ASPARTAME Recentemente colocado como "Possível Carcinógeno" pela OMS precisamos nos preocupar? podemos tomar uma Coca? Quais são as evidencias? referencias: Referencias: Debras C, Chazelas E, Srour B, Druesne-Pecollo N, Esseddik Y, Szabo de Edelenyi F, Agaësse C, De Sa A, Lutchia R, Gigandet S, Huybrechts I, Julia C, Kesse-Guyot E, Allès B, Andreeva VA, Galan P, Hercberg S, Deschasaux-Tanguy M, Touvier M. Artificial sweeteners and cancer risk: Results from the NutriNet-Santé population-based cohort study. PLoS Med. 2022 Mar 24;19(3):e1003950. doi: 10.1371/journal.pmed.1003950. Jones GS, Graubard BI, Ramirez Y, Liao LM, Huang WY, Alvarez CS, Yang W, Zhang X, Petrick JL, McGlynn KA. Sweetened beverage consumption and risk of liver cancer by diabetes status: A pooled analysis. Cancer Epidemiol. 2022 Aug;79:102201. doi: 10.1016/j.canep.2022.102201. Epub 2022 Jun 18. PMID: 35728406. Stepien, M. et al. Eur. J. Nutr. 55, 7–20 (2016).

Det finnes vel ikke enklere diagnoser enn urinveisinfeksjon? Tro om igjen! Ingrid og Jørgen snakker om UVI – fra hippokratisk pussdrenasje, videre til vår tids diagnostikk, profylakse og behandling. Og hvorfor skal man ikke behandle asymptomatisk bakteriuri? Få svar på ting du ikke visste at du lurte på i denne episoden om urinveisinfeksjoner. Vi minner forøvrig om retningslinjene på https://www.antibiotika.no/ både når det gjelder profylakse og behandling. Referanser: Tefekli A, Cezayirli F. The history of urinary stones: in parallel with civilization. ScientificWorldJournal. 2013;2013:423964.Nickel JC. Management of urinary tract infections: historical perspective and current strategies: Part 1--Before antibiotics. J Urol. 2005 Jan;173(1):21-6Cai T, Tiscione D, Cocci A, Puglisi M, Cito G, Malossini G, et al. Hibiscus extract, vegetable proteases and Commiphora myrrha are useful to prevent symptomatic UTI episode in patients affected by recurrent uncomplicated urinary tract infections. Arch Ital Urol Androl. 2018;90(3):203-7.Harding C, Chadwick T, Homer T, Lecouturier J, Mossop H, Carnell S, et al. Methenamine hippurate compared with antibiotic prophylaxis to prevent recurrent urinary tract infections in women: the ALTAR non-inferiority RCT. Health Technol Assess. 2022;26(23):1-172.Lee BS, Bhuta T, Simpson JM, Craig JC. Methenamine hippurate for preventing urinary tract infections. Cochrane Database Syst Rev. 2012;10(10):CD003265.Relis Metenamin (Hiprex) som profylakse ved residiverende urinveisinfeksjoner. https://relis.no/artikler/32945/ (28.04.23)Recurrent Uncomplicated Urinary Tract Infections in Women: AUA/CUA/SUFU Guideline (2022) https://www.auanet.org/guidelines-and-quality/guidelines/recurrent-uti (28.04.23)Clinical Practice Guideline for the Management of Asymptomatic Bacteriuria: 2019 Update by the Infectious Diseases Society of America. Clinical Infectious Diseases. Published CID, 3/21/2019. Hansson S, Jodal U, Lincoln K, Svanborg-Eden C. Untreated asymptomatic bacteriuria in girls: II--Effect of phenoxymethylpenicillin and erythromycin given for intercurrent infections. BMJ. 1989;298(6677):856-9.Hartman EAR, van de Pol AC, Heltveit-Olsen SR, Lindbaek M, Hoye S, Lithen SS, et al. Effect of a multifaceted antibiotic stewardship intervention to improve antibiotic prescribing for suspected urinary tract infections in frail older adults (ImpresU): pragmatic cluster randomised controlled trial in four European countries. BMJ. 2023;380:e072319.Jansaker F, Li X, Vik I, Frimodt-Moller N, Knudsen JD, Sundquist K. The Risk of Pyelonephritis Following Uncomplicated Cystitis: A Nationwide Primary Healthcare Study. Antibiotics (Basel). 2022;11(12).Vik I, Bollestad M, Grude N, Baerheim A, Damsgaard E, Neumark T, et al. Ibuprofen versus pivmecillinam for uncomplicated urinary tract infection in women-A double-blind, randomized non-inferiority trial. PLoS Med. 2018;15(5):e1002569. Hosted on Acast. See acast.com/privacy for more information.

In this episode of the Well Nurtured Brain, Dr. Pamela Hutchison discusses the big topic of social prescribing. Social prescribing is a practice that involves healthcare professionals referring patients to non-medical community activities, such as social clubs, volunteering opportunities, and exercise classes, as a way to improve their overall health and wellbeing. In today's episode we'll discuss: How social isolation and loneliness impact health including both physical and mental health. What's being shown in studies since the pandemic regarding brain health post social isolation. Why this is clinically relevant and how we can shift the narrative Episode Resources: Tools for clinicians  A Social History Tool using the IF-IT-HELPS mnemonic https://www.aafp.org/dam/AAFP/documents/patient_care/everyone_project/action-plan.pdf https://www.aafp.org/dam/AAFP/documents/patient_care/everyone_project/hops19-physician-guide-sdoh.pdf https://www.aafp.org/dam/AAFP/documents/patient_care/everyone_project/hops19-physician-form-sdoh.pdf UCLA Loneliness Scale https://fetzer.org/sites/default/files/images/stories/pdf/selfmeasures/Self_Measures_for_Loneliness_and_Interpersonal_Problems_UCLA_LONELINESS_REVISED.pdf Canada 211 https://211.ca/ Studies cited or used as resources for episodes Nowak, D. A., & Mulligan, K. (2021). Social prescribing: A call to action. Canadian family physician Medecin de famille canadien, 67(2), 88–91. https://doi.org/10.46747/cfp.670288 Perlman D., Peplau L.A. Toward a social psychology of loneliness. Pers. Relatsh. 1981;3:31–56.  Hutten, E., Jongen, E. M. M., Vos, A. E. C. C., van den Hout, A. J. H. C., & van Lankveld, J. J. D. M. (2021). Loneliness and Mental Health: The Mediating Effect of Perceived Social Support. International journal of environmental research and public health, 18(22), 11963. https://doi.org/10.3390/ijerph182211963 Cacioppo, J. T., & Cacioppo, S. (2018). Loneliness in the modern age: An evolutionary theory of loneliness (ETL). In Advances in experimental social psychology (Vol. 58, pp. 127-197). Academic press. McWhirter B.T. Loneliness: A review of current literature, with implications for counseling and research. J. Couns. Dev. 1990;68:417–422. doi: 10.1002/j.1556-6676.1990.tb02521.x. Subramanian, I., Farahnik, J. & Mischley, L.K. Synergy of pandemics-social isolation is associated with worsened Parkinson severity and quality of life. npj Parkinsons Dis. 6, 28 (2020). https://doi.org/10.1038/s41531-020-00128-9 Holt-Lunstad J, Smith TB, Layton JB (2010) Social Relationships and Mortality Risk: A Meta-analytic Review. PLoS Med 7(7): e1000316. https://doi.org/10.1371/journal.pmed.1000316 Additional resources WHO Social determinants of health https://www.who.int/health-topics/social-determinants-of-health#tab=tab_1   Connect with me: Pamela's Instagram: https://www.instagram.com/dr_pamela_hutchison_nd The Well Nurtured Brain's Instagram: https://www.instagram.com/the_well_nurtured_brain/ Facebook: https://www.facebook.com/profile.php?id=100089475401521&mibextid=LQQJ4d Website: www.TheWellNurturedBrain.com (coming soon!) Email: thewellnurturedbrain@gmail.com

Welcome to PsychEd, the psychiatry podcast for medical learners, by medical learners. This episode covers the Journey Through Stages of Sleep with Dr. Michael Mak, Assistant Professor in the Department of Psychiatry at the University of Toronto, and an Adjunct Research Professor at Western University.   The learning objectives for this episode are as follows:   Understand the basics of sleep physiology, including the stages of sleep Recognize the clinical features of insomnia disorder using the ICSD-3 and DSM-5-TR criteria  Develop an approach to the assessment of insomnia  Identify the pharmacological and non-pharmacological treatments for insomnia disorder    Guest: Dr. Michael Mak (Staff Psychiatrist)   Hosts: Dr. Vanessa Aversa (PGY4), Andreea Chiorean (CC4), Sena Gok (IMG)   Audio editing by: Sena Gok   Show notes by: Sena Gok   Contents: Introduction:  0:16 Learning Objectives:  01:49 Definition and  Clinical features of insomnia (ICSD-3 and DSM-5-TR criteria):  02:39 Insomnia prevalence, cost effects:  05:25 Sleep physiology:  10:05 Stages of Sleep:  11:37 Changes in Sleep stages during Insomnia:  14:35 Melatonin/Orexin systems:  15:45 Assessment and diagnosis of Insomnia:  21:00 Risk Factors of Insomnia:  30:12 CBT for Insomnia (CBT-I):  31:35 Relaxation-based techniques:  40:25 Contraindication for Insomnia:  42:15 Pharmacological treatments of insomnia:  45:15 Summary:  1:11:10 Resources: 1. Wainberg M, Jones SE, Beaupre LM, Hill SL, Felsky D, Rivas MA, et al. Association of accelerometer-derived sleep measures with lifetime psychiatric diagnoses: A cross-sectional study of 89,205 participants from the UK Biobank. PLOS Med. 2021 Oct 12;18(10):e1003782.  2. Morin CM, Vallières A, Guay B, Ivers H, Savard J, Mérette C, et al. Cognitive Behavioral Therapy, Singly and Combined With Medication, for Persistent Insomnia: A Randomized Controlled Trial. JAMA. 2009 May 20;301(19):2005–15. : 3. Crescenzo FD, D'Alò GL, Ostinelli EG, Ciabattini M, Franco VD, Watanabe N, et al. Comparative effects of pharmacological interventions for the acute and long-term management of insomnia disorder in adults: a systematic review and network meta-analysis. The Lancet. 2022 Jul 16;400(10347):170–84.  4. Watanabe Y, Kuroki T, Ichikawa D, Ozone M, Uchimura N, Ueno T. Effect of smartphone-based cognitive behavioral therapy app on insomnia: a randomized, double-blind study. Sleep. 2023 Mar 1;46(3):zsac270.  5. Erland LAE, Saxena PK. Melatonin Natural Health Products and Supplements: Presence of Serotonin and Significant Variability of Melatonin Content. J Clin Sleep Med. 13(02):275–81.  6. Sweetman A, McEvoy RD, Smith S, Catcheside PG, Antic NA, Chai-Coetzer CL, et al. The effect of cognitive and behavioral therapy for insomnia on week-to-week changes in sleepiness and sleep parameters in patients with comorbid insomnia and sleep apnea: a randomized controlled trial. Sleep. 2020 Jul 13;43(7):zsaa002.  7.  Origins of Sleep Medicine: Dr. Nathaniel Kleitman,, Dr. Mark Mahowald, Dr. Carlos Schenck https://aasm.org/mark-mahowald-md-and-carlos-schenck-md-to-receive-william-c-dement-award/ 8.  CBT-Insomnia lab at the Toronto Metropolitan University: https://drcolleencarney.com/lab/ 9.  CBT-Insomnia Applications:  https://www.sleepio.com/  https://www.ptsd.va.gov/appvid/mobile/cbticoach_app_public.asp  https://www.blackdoginstitute.org.au/research-projects/sleep-ninja/  https://www.somryst.com/ CPA Note: The views expressed in this podcast do not necessarily reflect those of the Canadian Psychiatric Association. For more PsychEd, follow us on Twitter (@psychedpodcast), Facebook (PsychEd Podcast), and Instagram (@psyched.podcast). You can provide feedback by email at psychedpodcast@gmail.com. For more information, visit our website at psychedpodcast.org.

Is erythritol, the popular artificial sweetener, actually safe for our hearts? In this video, we dive into a recent study published in Nature Medicine that reveals the potential long-term health effects of erythritol. Despite being labeled as "non-nutritive," "zero calories," or "natural," this sweetener could be putting us at risk for major adverse cardiovascular events (MACE). Learn about the study's findings, which suggest that erythritol increases platelet activity and the formation of blood clots. Watch now to discover if your go-to low-calorie sweetener is putting your heart health at risk.References:Fagherazzi G, Vilier A, Saes Sartorelli D, Lajous M, Balkau B, Clavel-Chapelon F. Consumption of artificially and sugar-sweetened beverages and incident type 2 diabetes in the Etude Epidémiologique auprès des femmes de la Mutuelle Générale de l'Education Nationale–European Prospective Investigation into Cancer and Nutrition cohort–. The American journal of clinical nutrition. 2013 Jan 30;97(3):517-23.Imamura F, O'connor L, Ye Z, Mursu J, Hayashino Y, Bhupathiraju SN, Forouhi NG. Consumption of sugar sweetened beverages, artificially sweetened beverages, and fruit juice and incidence of type 2 diabetes: systematic review, meta-analysis, and estimation of population attributable fraction. Br J Sports Med. 20 Suez, J. et al. (2022) "Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance", Cell. doi: 10.1016/j.cell.2022.07.016. https://www.cell.com/cell/fulltext/S0092-8674(22)00919-916 Apr 1;50(8):496-504.Debras C. et al. Artificial sweeteners and cancer risk: Results from the NutriNet-Santé population-based cohort study. PLoS Med. 2022 Mar 24;19(3):e1003950. doi: 10.1371/journal.pmed.1003950. PMID: 35324894; PMCID: PMC8946744.Witkowski, M., Nemet, I., Alamri, H. et al. The artificial sweetener erythritol and cardiovascular event risk. Nat Med (2023). https://doi.org/10.1038/s41591-023-02223-9VISIT OUR STOREStore: https://www.selfelements.comFOLLOW USwww.selfprinciple.orgwww. youtube.com/selfprinciplewww.youtube.com/plantbasedkidneyhealthwww.instagram.com/seanhashmimd

*The information in this podcast is intended for Healthcare Practitioners. Despite women spending more of their lives in a post-menopausal state, there has been limited progress in how society views and supports menopausal women. In this episode, we are joined by Professor Mary Anne Lumsden, a leading researcher and menopause advocate, to examine menopause from all angles. Professor Lumsden explains that with appropriate biopsychosocial support, menopausal women can thrive and be revered. The conversation begins by exploring the evolutionary theory of the grandma hypothesis, which suggests that menopause is a feature rather than a bug. We delve into the menopausal transition and how symptoms, such as hot flushes, are not solely driven by an absolute estrogen deficiency. In this light, non-hormonal treatments are explored. Additionally, Professor Lumsden outlines the latest updates on the benefits and risks of menopausal hormone replacement therapy, suggesting that the risks may have been overstated in the past. We then turn to the health challenges that menopausal women often face, such as unwanted weight gain, body composition changes, osteoporosis, and dementia. Professor Lumsden provides insights on evidence-based clinical strategies to support women during this transitional phase of life. Tune in for a menopausal masterclass that offers an evolutionary, biopsychosocial, and clinical perspective on how menopausal women can thrive. Mary Ann Lumsden is the CEO of the International Federation of Gynecology and Obstetrics and former Professor of Medical Education & Gynaecology and Head of Reproductive & Maternal Medicine, University of Glasgow. She is Past Senior Vice President for Strategy at the Royal College of Obstetricians and Gynaecologists in London. Mary Ann has considerable experience of developing Guidelines. She was Chair of the Guidelines Development Group for the National Institute of Health and Care Excellence (NICE) Guideline ‘Menopause: Investigation and Management'. Her success in this field was recognised in 2017 when she was awarded an OBE (Officer of the Order of the British Empire) for Services to Women's Health. Links Lumsden MA, Sassarini J. The evolution of the human menopause. Climacteric. 2019;22(2):111-116. doi:10.1080/13697137.2018.1547701 (https://pubmed.ncbi.nlm.nih.gov/30712396/) Santen RJ, Heitjan DF, Gompel A, et al. Approach to Managing a Postmenopausal Patient. J Clin Endocrinol Metab. 2020;105(12):dgaa623. doi:10.1210/clinem/dgaa623 (https://pubmed.ncbi.nlm.nih.gov/32882039/) Zhang GQ, Chen JL, Luo Y, et al. Menopausal hormone therapy and women's health: An umbrella review. PLoS Med. 2021;18(8):e1003731. Published 2021 Aug 2. doi:10.1371/journal.pmed.1003731 (https://pubmed.ncbi.nlm.nih.gov/34339416/) https://www.figo.org/

In this episode we have two interviews about two different—but both very important—topics. In the second interview, Dr. Celestin Hategeka, from the Department of Global Health and Population, Harvard TH Chan School of Public Health, discusses his recently published systematic review in PLoS Medicine that identified several unmet needs in noncommunicable disease prevention, as well as control interventions, in low- and middle-income countries. But first, our regular contributor, Dr. MedLaw—a board-certified radiologist and medical malpractice attorney—discusses the important topic of employment contracts. As always, Dr. MedLaw serves us a fascinating twist with her insights! Enjoy listening!Additional reading:Hategeka C, Adu P, Desloge A, Marten R, Shao R, Tian M, Wei T, Kruk ME. Implementation research on noncommunicable disease prevention and control interventions in low- and middle-income countries: A systematic review. PLoS Med. 2022 Jul 25;19(7):e1004055.

Episode 6 is all about female sexual dysfunction: What it is, what it isn't, controversy, hormones, lube, and so much more. This is something that SO MANY women deal with & maybe it could answer some questions you have about your own body or someone elses! Give it a listen & don't judge me too hard on my sick voice, theme of the week is don't get the flu. This episode was sponsered by BetterHelp. You can sign up for 10% off your first month here: www.betterhelp.com/sassyspeculumAnd, you can contact me at sassyspeculum@gmail.com, on Insta @Sassyspeculum or anonymously at www.beatingheartdoula.com/sassyspeculumSources for Episode 6: Institute of Medicine (US) Committee on a National Surveillance System for Cardiovascular and Select Chronic Diseases. A Nationwide Framework for Surveillance of Cardiovascular and Chronic Lung Diseases. Washington (DC): National Academies Press (US); 2011. 2, Cardiovascular Disease. Available from: Moynihan R. The making of a disease: female sexual dysfunction. BMJ. 2003;326(7379):45-47. doi:10.1136/bmj.326.7379.45Bancroft J. The endocrinology of sexual arousal. J Endocrinol. 2005;186(3):411-427. doi:10.1677/joe.1.06233Berman JR, Berman LA, Toler SM, Gill J, Haughie S; Sildenafil Study Group. Safety and efficacy of sildenafil citrate for the treatment of female sexual arousal disorder: a double-blind, placebo controlled study. J Urol. 2003;170(6 Pt 1):2333-2338. doi:10.1097/01.ju.0000090966.74607.34Tiefer L (2006) Female Sexual Dysfunction: A Case Study of Disease Mongering and Activist Resistance. PLoS Med 3(4): e178. https://doi.org/10.1371/journal.pmed.0030178Addyi. UpToDate. (n.d.). Retrieved October 8, 2022,Vylessi. UpToDate (n.d.) Retrieved October 8, 2022 Sarwer DB, Durlak JA. A field trial of the effectiveness of behavioral treatment for sexual dysfunctions. J Sex Marital Ther 1997; 23:87.Addyi (flibanserin): 25 things you need to know. Addyi (Flibanserin): 25 Things You Need to Know: Sex & Relationship Therapist: Stephen Snyder, MD: (n.d.). Retrieved October 8, 2022, Berman JR, Berman L, Goldstein I. Female sexual dysfunction: incidence, pathophysiology, evaluation, and treatment options. Urology. 1999;54(3):385-391.Sexual Dysfunction Caused by Selective Serotonin Reuptake Inhibitors. UpToDate. (n.d.). Retrieved October 8, 2022, Overview of Sexual Dysfunction in Women Management. UpToDate. (n.d.). Retrieved October 8, 2022Gaber MA, Shaltout SA. Assessment of autologous platelet-rich plasma as a local therapy for female sexual dysfunction. Menoufia Med J 2021;34:61-5Platelet-rich plasma (PRP) injections. Johns Hopkins Medicine. (2021, August 23). Retrieved October 8, 2022,Krakowsky Y, Grober ED. A practical guide to female sexual dysfunction: An evidence-based review for physicians in Canada. Can Urol Assoc J. 2018;12(6):211-216. doi:10.5489/cuaj.4907CBS Publishers & Distributors, Pvt. Ltd. (2017). Diagnostic and statistical manual of mental disorders: Dsm-5. Dr. Tammy Ashney, 2022, Female Sexual Dysfunction, National University of Natural Medicine, Winter 2022

歡迎嚟到 搞乜咁科學 GMG Science 第7集！今集嘅主題係錯處 Mistake❌！Keith會講一個係人都會犯嘅錯，Abellona會解釋細胞點樣處理DNA嘅錯誤？而咩情況又會特登製造錯誤？喂！好奇心，係時候醒喇 :)Social Media:科學一齊搞 Got Something for GMG - 有咩想同我哋講都可以係度share㗎: https://forms.gle/26RSEgW9NeeSMc4a7搞乜咁科學網頁: www.gmgscience.com搞乜咁科學 IG: www.instagram.com/gmgscience搞乜咁科學 YouTube: https://www.youtube.com/channel/UCFj2cwjDASS2SyYsj3pkNSQAbellona IG: www.instagram.com/_doctor_uKeith IG: www.instagram.com/keith.poonsirKeith YouTube: https://www.youtube.com/channel/UC9fh5paH2jh5kfBVDEPC1YAShow Notes and Links:大部份今集有關嘅圖片會係我哋IG見到㗎: www.instagram.com/gmgscienceKeith part:Wald Abraham 沃德·亞伯拉罕 - Wikipedia 倖存者偏誤 Survival Bias - Wikipedia 康城站 LOHAS Park Station - Fandomxkcd 漫畫 再現危機 Replication crisis - Wikipedia 用細隻啲嘅碟幫唔到你減肥?! 發表偏差 Publication bias - Wikipedia 號外！！！科學證實: [自行輸入任意人類群組]會因為[自行輸入任意行為]而導致[自行輸入任意疾病] - Cartoon by Jim Borgman, 1997 大部份科學文獻出版結果都是錯嘅?! - Ioannidis JPA (2005) Why Most Published Research Findings Are False. PLoS Med 2(8): e124.延伸閱讀:How Not to Be Wrong - The Power of Mathematical Thinking by Jordan EllenbergAbellona part:DNA 修復 - Wikipedia  TEDed 介紹DNA 修復的短片 抗體 - Wikipedia  抗體多樣性的生成 

It turns out femicide in SA is a uniquely scary phenomenon that warrants its own investigation. Jody unpacks her MA thesis in this episode. GBV resources: The Warrior Project: https://thewarriorproject.org.za/what-can-i-do/?gclid=Cj0KCQjwhqaVBhCxARIsAHK1tiPv6WkNpIXXYq7cOcXFvp5PqCGwMlDVi9jnyPISAinJi740a3mk-CYaAmupEALw_wcB Safer Spaces: https://www.saferspaces.org.za/resources/entry/new-materials-for-gbv-survivors Sources: Jody van der Heyde, 2020, A portrait of intimate femicide in South Africa, MA Thesis, The University of Manchester. Contact for a copy. Abrahams, N., et al. (2009). ‘Mortality of women from intimate partner violence in South Africa: a national epidemiological study', Violence and Victims, 24(4), Abrahams, N. et al. (2013). ‘Intimate partner femicide in South Africa in 1999 and 2009.', PLos Med, 10(4). Research brief: Decrease in Femicide in South Africa: Three National Studies across 18 Years, South African Medical Research Council, 2022. https://www.samrc.ac.za/reports/research-brief-decrease-femicide-south-africa-three-national-studies-across-18-years . Watch the release on the study on https://www.youtube.com/watch?v=iW0zwFMuOS0&t=715s Isaacs, D. and Mthembu, J. (2018). ‘“I forgive him. It wasn't easy for him”: social representations of perpetrators of intimate partner violence in the Western Cape Province media', Critical Studies in Media Communication, 35(5), Moffett, H. (2006). ‘“These women, they force us to rape them”: rape as a narrative of social control in post-apartheid South Africa', Journal of Southern African Studies, 32(1),

In this episode, Marc and Mo discuss a couple of recent JBJS and OE articles that caught their eye. The first part of the discussion focuses on a number of provocative questions related to the topic of reproducibility in science, while the second part focuses on a recent RCT on the impact of perioperative nutrition on patient outcomes, with a call for additional research in this area. Links: Bhandari M, Silburt J. Reproducibility in Science: a Crisis in Confidence? Ortho Evidence. 14 May 2022. Article Number 92. https://bit.ly/3NjjKuA Ioannidis JP. Why most published research findings are false. PLoS Med. 2005 Aug;2(8):e124. doi: 10.1371/journal.pmed.0020124. Epub 2005 Aug 30. PMID: 16060722; PMCID: PMC1182327. https://bit.ly/3Prta9h Hendrickson NR, Davison J, Glass NA, Wilson ES, Miller A, Leary S, Lorentzen W, Karam MD, Hogue M, Marsh JL, Willey MC. Conditionally Essential Amino Acid Supplementation Reduces Postoperative Complications and Muscle Wasting After Fracture Fixation: A Randomized Controlled Trial. J Bone Joint Surg Am. 2022 May 4;104(9):759-766. doi: 10.2106/JBJS.21.01014. Epub 2022 Mar 14. PMID: 35286282. https://bit.ly/3wzrpQ5 Subspecialties: Basic Science Trauma Orthopaedic Essentials

＜お知らせ＞ ◆Voicy新チャンネル開設！【獣医Sara先生の一問一答】 https://bit.ly/3sLljup ＜お知らせ＞ ◆４月１日夜２１時～ VoicyにてLIVEをします！（獣医Sara先生のお悩み相談会） https://bit.ly/3Lhjefq ◆Clubhouseでもお話ししたヨ！ 狂犬病ワクチンについて（アーカイブを聴くなら今だけ！ （４月２日まで） https://bit.ly/3NsPjTt 獣医Sara先生のお悩み相談会：ご質問４つにお答えしました！ https://bit.ly/3K4MhTC ＜Standfm メンバーシップ：メンバーになりませんか？＞ 【ペットのホリスティックケアCLUB】 みんなでギネス長寿記録を目指す！ ５つの特典アリ！【人もペットも一緒に健康で長生きしよう】プロジェクト始動！

Neste episódio vou comentar sobre o POEM publicado na área da página da BVS APS chamada “Revisões Comentadas - POEMS”, falando sobre um estudo de coorte retrospectivo usando bancos de dados clínicos representativos da população do Reino Unido, para avaliar o desempenho do exame CA-125 em mulheres com suspeita de câncer de ovário atendidas na APS. Aproveito para falar um pouco sobre sensibilidade, especificidade e valor preditivo positivo e negativo nas avaliações de performance dos testes diagnósticos. Funston G, Hamilton W, Abel G, Crosbie EJ, Rous B, Walter FM. The diagnostic performance of CA125 for the detection of ovarian and non-ovarian cancer in primary care: A population-based cohort study. PLoS Med 2020;17(10):e1003295. Disponível em: https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1003295

In this episode from the IPS conference, Prof Brett Mitchell is joined by Dr Evonne Curran who has worked in the field of infection prevention and control for a number of years, was a Nurse Consultant with Health Protection Scotland and is now an independent consultant. Together they discuss the relevance of guidelines to clinical practice and whether the development process is really producing guidance that is useful in the field of nfection prevention. In this podcast these papers are referred to: Smith GC, Pell JP Parachute use to prevent death and major trauma related to gravitational challenge: systematic review of randomised controlled trials. BMJ 2003; 327: 1459-61. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC300808/pdf/32701459.pdf Yeh RW, Valsdottir LR, Yeh MW et al. Parachute use to prevent death and major trauma when jumping from aircraft: randomized controlled trial. BMJ 2018; 363: k5094. https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/30545967/ Greenhalgh T Will COVID-19 be evidence-based medicine's nemesis? PLoS Med 2020; 17: e1003266. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326185/pdf/pmed.1003266.pdf

In this episode from the IPS conference, Prof Brett Mitchell is joined by Dr Evonne Curran who has worked in the field of infection prevention and control for a number of years, was a Nurse Consultant with Health Protection Scotland and is now an independent consultant. Together they discuss the relevance of guidelines to clinical practice and whether the development process is really producing guidance that is useful in the field of nfection prevention. In this podcast these papers are referred to: Smith GC, Pell JP Parachute use to prevent death and major trauma related to gravitational challenge: systematic review of randomised controlled trials. BMJ 2003; 327: 1459-61. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC300808/pdf/32701459.pdf Yeh RW, Valsdottir LR, Yeh MW et al. Parachute use to prevent death and major trauma when jumping from aircraft: randomized controlled trial. BMJ 2018; 363: k5094. https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/30545967/ Greenhalgh T Will COVID-19 be evidence-based medicine's nemesis? PLoS Med 2020; 17: e1003266. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326185/pdf/pmed.1003266.pdf

When asked what we treasure most, people readily respond with one word—relationships. Our friends, family, and romantic partners enrich our lives in myriad ways, providing encouragement, support, affection, and joy. Except when they don't. When our relationships are in crisis, our life is in crisis and when they're thriving, we thrive. As Tony Robbins puts it, “The quality of your life is the quality of your relationships.” So, why is it such a struggle to maintain healthy and fulfilling intimacy in our lives? Great question! And, today's episode provides answers! Join me to learn three research-based hacks to improve EVERY relationship in your life—your connection to friends, family, and significant others! Citations: Hawkley, L.C., Thisted, R.A., Masi, C.M., & Cacioppo, J.T. (2010). Loneliness predicts increased blood pressure: 5-year cross-lagged analyses in middle-aged and older adults. Psychology and Aging, 25(1), 132-141. Holt-Lunstad, J., Smith, T., & Layton, B. (2010). Social relationships and mortality risk: A meta-analytic review. J.PLoS Med 7 (7). Kroenke, C., Quesenberry, C., Kwan, M., Sweeney, C., Castillo, A., & Caan, B. (2013). Social networks, social support, and burden in relationships, and mortality after breast cancer diagnosis in the Life After Breast Cancer Epidemiology (LACE) Study. Breast Cancer Research and Treatment, 137(1), 261-271. Luhmann, M., Hofmann, M., Eid, W., & Lucas, R. (2012). Subjective well-being and adaptation to life events: A meta-analysis. Journal of Personality & Social Psychology, 102(3), 592-615. Dr. Karin Single is the New Black - Audiobook Audible: smarturl.it/SITNB-Audible iTunes: smarturl.it/SITNB-iTunes -------------------------------------------------------- Website: http://loveandlifemedia.com/ Instagram: @dr.karin --- Support this podcast: https://anchor.fm/love-and-life-media/support

Those with type 2 diabetes are often told to avoid fruit because the fructose will cause their blood sugars to rise. Unfortunately, by avoiding fresh fruit, those with T2D are missing out on all the fiber, antioxidants, vitamins and minerals that fruit provides ... not to mention the pure delight in eating a fresh strawberry. This episode gives you the facts about fruit consumption for diabetics. Interested in more information? Let's chat about how I can help you! Schedule a FREE breakthrough call with me: https://schedule-robinwong.as.me/ Download my 3 Breakfasts to Lower Blood Sugar: https://page.nutritionwithrobinrdn.com/guide Topic inspired by Center for Nutrition Studies article Du H, Li L, Bennett D, Guo Y, Turnbull I, Yang L, Bragg F, Bian Z, Chen Y, Chen J, Millwood IY, Sansome S, Ma L, Huang Y, Zhang N, Zheng X, Sun Q, Key TJ, Collins R, Peto R, Chen Z; China Kadoorie Biobank study. Fresh fruit consumption in relation to incident diabetes and diabetic vascular complications: A 7-y prospective study of 0.5 million Chinese adults. PLoS Med. 2017 Apr 11;14(4):e1002279.Hertog MG, Bueno-de-Mesquita HB, Fehily AM, Sweetnam PM, Elwood PC, Kromhout D. Fruit and vegetable consumption and cancer mortality in the Caerphilly Study. Cancer Epidemiol Biomarkers Prev. 1996 Sep;5(9):673-7. Tian X, Du H, Li L, Bennett D, Gao R, Li S, Wang S, Guo Y, Bian Z, Yang L, Chen Y, Chen J, Gao Y, Weng M, Pang Z, Jiang B, Chen Z; China Kadoorie Biobank study. Fruit consumption and physical activity in relation to all-cause and cardiovascular mortality among 70,000 Chinese adults with pre-existing vascular disease. PLoS One. 2017 Apr 12;12(4):e0173054. Bellavia A, Larsson SC, Bottai M, Wolk A, Orsini N. Fruit and vegetable consumption and all-cause mortality: a dose-response analysis. Am J Clin Nutr. 2013 Aug;98(2):454-9. Lim, S.S.; Vos, T. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors 
and risk factor clusters in 21 regions, 1990–2010: A systematic analysis for the Global Burden of Disease 
Study 2010. Lancet 2012, 380, 2224–2260.

It is common practice to use mortality as a primary outcomes variable, particularly in critical care research. Today, we welcome Dr, Eric Benoit to the Podcast to discuss why this may not always be the best approach and the other ways we can examine outcomes in clinical-based research. We will touch on topics such as composite outcomes, quality adjusted life years, the treatment effect and the infrequently discussed fragility index. Selected references: Harhay, et al. “Outcomes & statistical power in adult critical care randomized trials.” Am J Respir Crit Care Med 2014. PMID 24786714 Kent & Trikalinos. “Therapeutic innovations, diminishing returns, and control rate preservation.” JAMA 2009. PMID 19934428 Sackett. “Why randomized controlled trials fail but needn't: 2. Failure to employ physiologic statistics, or the only formula a clinician-trialist is ever likely to need (or understand!)” Can Med Assoc J 2001. PMID 11706914 Tignanelli & Napolitano. “The Fragility Index in randomized controlled trials as a means of optimizing patient care.” JAMA Surgery 2019. PMID 30422256 Ioannidis. “Why most published research findings are false.” PLoS Med 2005. PMID 16060772

Join Garden Variety Perverts as we tour the anarchist's garden and learn about common plants with defensive and deadly properties!   Notoriously pious hosts James and Jared introduce you to the natural history and chemical properties of: stinging nettle (Urtica dioica L.), morning glory (Ipomoea purpurea [L.] Roth), foxglove (Digitalis purpurea L.), death camas (Toxicoscordion venenosum [S.Watson] Rydb.), poison hemlock (Conium maculatum L.), water hemlock (Cicuta maculata L.), lily of the valley (Convallaria majalis L.), castor bean (Ricinus communis L.), and the Big Bad itself – motherflippin' poison ivy (Toxicodendron radicans [L.] Kuntze).   Enjoy the fine aromas of compost as we mix botany's heritage of Enlightenment-era racism and ancient Greek pederasty with modern medicine and organic chemistry. Has your boss been described as “effective, but harsh”? This is the podcast for you!   WARNING: Podcasts are an audial medium and plant identification depends on visual stimulus. Do not rely on this or any other podcast to identify plants, especially those which may be toxic. Neither Compost Bin of History nor Garden Variety Perverts condone plant-based violence. CTFO.   Links to sources:   Ioannidis JPA (2005) Why Most Published Research Findings Are False. PLoS Med 2(8): e124. https://doi.org/10.1371/journal.pmed.0020124   Editors of Erowid (????) Everything on Erowid cause it's great. https://erowid.org/splash.php   Caselli, Irene (2010) Ecuador's indigenous justice system on trial. BBC. https://www.bbc.com/news/world-latin-america-10683003   Garms, Gabe (2015) How to Tell the Difference Between Poison Hemlock and Queen Anne's Lace. Raven's Roots Naturalist School. http://ravensroots.org/blog/2015/6/26/poison-hemlock-id   Lindquist, Karen (2020) How to Identify Water Hemlock. WikiHow. https://www.wikihow.com/Identify-Water-Hemlock  

What puts the quasi in quasi-experimental designs? What makes a quasi-experimental study different than a “real” experiment? Ever wondered about the difference between regression discontinuity, difference-in-differences, and synthetic control methods? Dr. Tarik Benmarnhia joins us on this episode of SERious Epidemiology to talk us through a range of quasi-experimental designs. He makes a strong case for why we should integrate these designs in a variety of settings in epidemiology ranging from public health policy to clinical epidemiology After listening to this podcast, if you are interested in learning more about quasi-experimental designs, you can check out some of the resources below: Abadie A, Diamond A, Hainmueller J. (2010) Synthetic Control Methods for Comparative Case Studies: Estimating the Effect of California’s Tobacco Control Program, Journal of the American Statistical Association, 105:490, 493-505, DOI: 10.1198/jasa.2009.ap08746 Chen H, Li Q, Kaufman JS, Wang J, Copes R, Su Y, Benmarhnia T. Effect of air quality alerts on human health: a regression discontinuity analysis in Toronto, Canada. Lancet Planet Health. 2018 Jan;2(1):e19-e26. doi: 10.1016/S2542-5196(17)30185-7. Epub 2018 Jan 9. PMID: 29615204. Auger N, Kuehne E, Goneau M, Daniel M. Preterm birth during an extreme weather event in Québec, Canada: a "natural experiment". Matern Child Health J. 2011 Oct;15(7):1088-96. doi: 10.1007/s10995-010-0645-0. PMID: 20640493. Hernán MA, Robins JM. Instruments for causal inference: an epidemiologist's dream? Epidemiology. 2006 Jul;17(4):360-72. doi: 10.1097/01.ede.0000222409.00878.37. Erratum in: Epidemiology. 2014 Jan;25(1):164. PMID: 16755261. Courtemanche, C., Marton, J., Ukert, B., Yelowitz, A. and Zapata, D. (2017), Early Impacts of the Affordable Care Act on Health Insurance Coverage in Medicaid Expansion and Non‐Expansion States. J. Pol. Anal. Manage., 36: 178-210. https://doi.org/10.1002/pam.21961 Bor J, Fox MP, Rosen S, Venkataramani A, Tanser F, Pillay D, Bärnighausen T. Treatment eligibility and retention in clinical HIV care: A regression discontinuity study in South Africa. PLoS Med. 2017 Nov 28;14(11):e1002463. doi: 10.1371/journal.pmed.1002463. PMID: 29182641; PMCID: PMC5705070. Bor J, Moscoe E, Mutevedzi P, Newell ML, Bärnighausen T. Regression discontinuity designs in epidemiology: causal inference without randomized trials. Epidemiology. 2014 Sep;25(5):729-37. doi: 10.1097/EDE.0000000000000138. PMID: 25061922; PMCID: PMC4162343. Elder TE. The importance of relative standards in ADHD diagnoses: evidence based on exact birth dates. J Health Econ. 2010;29(5):641-656. doi:10.1016/j.jhealeco.2010.06.003 Smith LM, Kaufman JS, Strumpf EC, Lévesque LE. Effect of human papillomavirus (HPV) vaccination on clinical indicators of sexual behaviour among adolescent girls: the Ontario Grade 8 HPV Vaccine Cohort Study. CMAJ. 2015;187(2):E74-E81. doi:10.1503/cmaj.140900

Tanvi Avasthi (@tanvicious) speaks with us today about narrative therapy, loss and trauma, and the power of asking "what do you want?" to recenter our patients as protagonists of their own lives. She explains how we can avoid pathologizing our patients and ourselves, and how we can resist the forces of white supremacy and capitalism which are attempting to destroy us and make us hate ourselves. She shows us a way of beautifully holding the humanity, justice, and poetry of healing together. SMOA producer Raghav Goyal joins this conversation as cohost. Tanvi holds masters degrees in Medical Anthropogy and in Nursing and currently works as an ER nurse in Batimore, and is a future Midwife and Women's Health Nurse Practitioner. In addition to her clinical work, she also has experience working as a doula and yoga instructor, and we know her through her work as one of the co-founders of the Campaign Against Racism, an activist group with chapters all around the world, that is using tools of restorative justice, narrative therapy, and community organizing to effect local and systems wide change. Her recommended resources: Narrative Medicine Suggested Questions (PDF), bit.ly/2I14rdN Narrative Therapy slides (Campaign Against Racism online presentation, Tanvi Avasthi, 2020), bit.ly/2Gt1h1X Charon R, Wyer P; NEBM Working Group. Narrative evidence based medicine. Lancet. 2008 Jan 26;371(9609):296-7. bit.ly/389Aweb Kleinman A, Benson P. Anthropology in the clinic: the problem of cultural competency and how to fix it. PLoS Med. 2006 Oct;3(10):e294. bit.ly/2JunJZy

What we eat. How we train. When we go to bed. Much of what we do to stay healthy and happy involves only ourselves. We often overlook how other people - our real and perceived social connections - affect our pursuit of a most excellent life. The people with whom we spend our time influence our habits and behaviors, and poor social ties have been linked to cardiovascular disease, atherosclerosis, autonomic dysregulation, high blood pressure, cancer, inflammatory biomarkers, and impaired immune function (1). A 2010 review found that those with stronger social relationships had a 50% increased likelihood of survival over a given period of time than those with weaker social relationships, an influence comparable to smoking and alcohol consumption and exceeding factors such as physical inactivity and obesity (2). Even subjective loneliness has been found to be a risk factor for cardiovascular, metabolic, inflammatory, immune, and stress-related issues, in addition to fragmented sleep and diminished impulse control (3). You might be curious whether digital and/or online relationships can serve the same purpose as relationships in real life. Research on the effects of social media use on physical and mental health is inconclusive, revealing a variety of beneficial and detrimental effects (4). You'll want to figure out for yourself what role social media plays in your pursuit of health and happiness. Here are some ideas, though, to help you cultivate meaningful connections in real life. Maintain regular contact with family members. Reach out to old friends, even if only by phone or text. Seek out new relationships through interest groups, volunteer opportunities, or spiritual gatherings. You might even simply get out of the house to spend time in public around other people. Finally, consider how those around you influence your thoughts, emotions, and actions. You are worthy of being around those who elevate you to a better life. What ideas do you have for fostering social connection? How can you start putting those ideas into practice? What steps can you take today to get started? Do what you can. That's all you can do. You've got this. 1) Umberson D, Montez JK. Social relationships and health: a flashpoint for health policy. J Health Soc Behav. 2010;51 Suppl(Suppl):S54-S66. doi:10.1177/0022146510383501 2) Holt-Lunstad J, Smith TB, Layton JB. Social relationships and mortality risk: a meta-analytic review. PLoS Med. 2010;7(7):e1000316. Published 2010 Jul 27. doi:10.1371/journal.pmed.1000316 3) Cacioppo JT, Cacioppo S. Social Relationships and Health: The Toxic Effects of Perceived Social Isolation. Soc Personal Psychol Compass. 2014;8(2):58-72. doi:10.1111/spc3.12087 4) Giustini D, Ali SM, Fraser M, Kamel Boulos MN. Effective uses of social media in public health and medicine: a systematic review of systematic reviews. Online J Public Health Inform. 2018;10(2):e215. Published 2018 Sep 21. doi:10.5210/ojphi.v10i2.8270

Find out more about our sewers from the In Deep podcast at https://www.indeep.org. The old combined sewer systems of many major cities are no match for modern storms and impermeable surfaces. Thanks also to our Patreon patrons https://www.patreon.com/MinuteEarth and our YouTube members. ___________________________________________ To learn more, start your googling with these keywords: Combined Sewer System: Sewers designed to collect domestic sewage and storm runoff in the same wastewater pipe. Wastewater Treatment Plant: A facility that filters and cleans wastewater before sending it into nearby waterways. Combined Sewer Overflow: When the wastewater in a combined sewer system exceeds a certain limit, it bypasses the wastewater treatment plant and goes directly into nearby waterways. Extreme Rainfall: Storms that cause the wettest days of the year in a particular geographic area. Invasive Species: Any kind of organism that gets introduced to a new environment and causes harm. Deep Tunnel Project: A $3 billion civil engineering megaproject designed to reduce flooding in the metropolitan Chicago area. _________________________________________ Subscribe to MinuteEarth on YouTube: http://goo.gl/EpIDGd Support us on Patreon: https://goo.gl/ZVgLQZ And visit our website: https://www.minuteearth.com/ Say hello on Facebook: http://goo.gl/FpAvo6 And Twitter: http://goo.gl/Y1aWVC And download our videos on itunes: https://goo.gl/sfwS6n ___________________________________________ Credits (and Twitter handles): Script Writer, Narrator, and Video Director: David Goldenberg (@dgoldenberg) Video Illustrator: Arcadi Garcia Rius (@garirius) With Contributions From: Henry Reich, Alex Reich, Ever Salazar, Peter Reich, Julián Gómez, Kate Yoshida, Sarah Berman Music by: Nathaniel Schroeder: http://www.soundcloud.com/drschroeder ___________________________________________ References: Tibbets, J. (2005). Combined Sewer Systems: Down, Dirty, and Out of Date. Environmental Health Perspectives. 113(7): A464–A467. Retrieved from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1257666/. Olds HT, Corsi SR, Dila DK, Halmo KM, Bootsma MJ, McLellan SL. (2018). High levels of sewage contamination released from urban areas after storm events: A quantitative survey with sewage specific bacterial indicators. PLoS Med. 15(7): e1002614. Retrieved from: https://doi.org/10.1371/journal.pmed.1002614. Walsh, J., D. Wuebbles, K. Hayhoe, J. Kossin, K. Kunkel, G. Stephens, P. Thorne, R. Vose, M. Wehner, J. Willis, D. Anderson, S. Doney, R. Feely, P. Hennon, V. Kharin, T. Knutson, F. Landerer, T. Lenton, J. Kennedy, and R. Somerville. (2014) Ch. 2: Our Changing Climate. Climate Change Impacts in the United States: The Third National Climate Assessment, J. M. Melillo, Terese (T.C.) Richmond, and G. W. Yohe, Eds., U.S. Global Change Research Program, 19-67. Retrieved from: https://nca2014.globalchange.gov/report/our-changing-climate/heavy-downpours-increasing Melosi, Martin. (2000). The Sanitary City: Urban Infrastructure in America from Colonial Times to the Present. Johns Hopkins University Press. Grabar, Henry. (2019). Tunnel Vision. Slate. Retrieved from: https://slate.com/business/2019/01/chicagos-deep-tunnel-is-it-the-solution-to-urban-flooding-or-a-cautionary-tale.html

In this episode Lamaze certified childbirth educator and doula LaToya is sharing evidence based research and exposing myths about TOLAC (Trial of Labor After Cesarean) & VBAC (Vaginal Birth After Cesarean). Would you like to hear certain topics discussed? Feel free to send and email to latoya@lamazedoula.com or an inbox message on the social media outlets listed below! It's a pleasure serving you! www.lamazedoula.com Meet her on the GRAM!: www.instagram.com/doulaviewllc and on Facebook: www.facebook.com/TheLamazeDoula References: National Guideline Clearinghouse (NGC). Guideline synthesis: Vaginal birth aftercesarean (VBAC). In: National Guideline Clearinghouse (NGC) http://www.guideline.gov/syntheses/synthesis.aspx?id=25231. Rockville (MD): Agency for Healthcare Research and Quality (AHRQ); 2011 Jan. [cited 2015 April 13]. Available: http://www.guideline.gov. 2 Osterman, M.J.K., Martin, J.A. (2014). Trends in low-risk cesarean delivery in the United States, 1990–2013. National vital statistics reports; vol 63 no 6. National Center for Health Statistics. Retrieved from http://www.cdc.gov/nchs/data/nvsr/nvsr63/nvsr63_06.pdf 4 Crowther, C.A., Dodd, J.M., Hiller, J.E., Haslam, R.R., Robinson, J.S., … (2012). Planned Vaginal Birth or Elective Repeat Caesarean: Patient Preference Restricted Cohort with Nested Randomised Trial. PLoS Med. 2012; 9(3). doi: 10.1371/journal.pmed.100119 6 Mercer, B., Gilbert, S., Landon, M.B., Spong, C.Y., Leveno, K.J., Rouse, D.J., … Ramin, S.M. (2008). Labor Outcomes with Increasing Number of Prior Vaginal Births after Cesarean Delivery. Obstetrics & Gynecology. 2008; 111(2-1): 285-291. doi 10.1097/AOG.0b013e31816102b9 --- Support this podcast: https://anchor.fm/thelamazedoula/support

¡Gracias por escuchar! En este episodio hablaré del papel que juega la inflamación en la generación de dolor en pacientes con osteoartritis. La OA tiene una morbilidad asociada sustancial y constituye un creciente problema de salud pública derivado en gran medida del envejecimiento poblacional. Los síntomas de la OA pueden ser funcionales pero se manifiestan principalmente como dolor y el manejo de la enfermedad se centra principalmente en su control.Agradezco que escuchen este podcast y les recuerdo que se encuentra disponible en el catálogo de iTunes, en Google Play (siendo accesible a través del gestor de podcasts de su dispositivo móvil), así como en Spotify. Agradezco también su retroalimentación en estas plataformas y les pido amablemente que califiquen el podcast ya que esto es importante para su continuado desarrollo.A continuación se enlistan las referencias mencionadas en este episodio: Grace, P. M., Hutchinson, M. R., Maier, S. F. & Watkins, L. R. Pathological pain and the neuroimmune interface. Nat. Rev. Immunol. 14, 217–231(2014).Owens, C. & Conaghan, P. G. Improving joint pain and function in osteoarthritis. Practitioner 260, 17–20 (2016).O’Neil, C. K., Hanlon, J. T. & Marcum, Z. A. Adverse effects of analgesics commonly used by older adults with osteoarthritis: focus on non-opioid and opioid analgesics. Am. J. Geriatr. Pharmacother. 10, 331–342 (2012).Wang, Y., Teichtahl, A. J. & Cicuttini, F. M. Osteoarthritis year in review 2015: imaging. Osteoarthritis Cartilage 24, 49–57 (2016).Haringman, J. J., Smeets, T. J., Reinders-Blankert, P. & Tak, P. P. Chemokine and chemokine receptor expression in paired peripheral blood mononuclear cells and synovial tissue of patients with rheumatoid arthritis, osteoarthritis, and reactive arthritis. Ann. Rheum. Dis. 65, 294–300 (2006).de Lange-Brokaar, B. J. et al. Degree of synovitis on MRI by comprehensive whole knee semi-quantitative scoring method correlates with histologic and macroscopic features of synovial tissue inflammation in knee osteoarthritis. Osteoarthritis Cartilage 22, 1606–1613 (2014).Cook, A. D., Christensen, A. D., Tewari, D., McMahon, S. B. & Hamilton, J. A. Immune cytokines and their receptors in inflammatory pain. Trends Immunol. 39, 240–255 (2018).Malfait, A. M. & Schnitzer, T. J. Towards a mechanism-based approach to pain management in osteoarthritis. Nat. Rev. Rheumatol. 9, 654–664 (2013).Bellamy, N. et al. Intraarticular corticosteroid for treatment of osteoarthritis of the knee. Cochrane Database Syst. Rev. 2, CD005328 (2006).McAlindon, T. E. et al. Effect of intra-articular triamcinolone versus saline on knee cartilage volume and pain in patients with knee osteoarthritis:a randomized clinical trial. JAMA 317, 1967–1975 (2017).Aitken, D. et al. A randomised double-blind placebo-controlled crossover trial of HUMira (adalimumab) for erosive hand OsteoaRthritis — the HUMOR trial. Osteoarthritis Cartilage 26, 880–887 (2018).Cohen, S. B. et al. A randomized, double-blind study of AMG 108 (a fully human monoclonal antibody to IL-1R1) in patients with osteoarthritis of the knee. Arthritis Res. Ther. 13, R125 (2011).Wang, S. X. et al. Safety, tolerability, and pharmacodynamics of an anti-interleukin-1alpha/beta dual variable domain immunoglobulin in patients with osteoarthritis of the knee: a randomized phase 1 study. Osteoarthritis Cartilage 25, 1952–1961 (2017).Eitner, A., Hofmann, G. O. & Schaible, H. G. Mechanisms of osteoarthritic pain. Studies in humans and experimental models. Front. Mol. Neurosci. 10, 349 (2017).Basbaum, A. I., Bautista, D. M., Scherrer, G. & Julius, D. Cellular and molecular mechanisms of pain. Cell 139, 267–284 (2009).Ji, R. R., Xu, Z. Z. & Gao, Y. J. Emerging targets in neuroinflammation-driven chronic pain. Nat. Rev. Drug Discov. 13, 533–548 (2014).McMahon, S. B., La Russa, F. & Bennett, D. L. Crosstalk between the nociceptive and immune systems in host defence and disease. Nat. Rev. Neurosci. 16, 389–402 (2015).Pinho-Ribeiro, F. A. et al. Blocking neuronal signaling to immune cells treats streptococcal invasive infection. Cell 173, 1083–1097 (2018).Shechter, R. et al. Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice. PLOS Med. 6, e1000113 (2009).Willemen, H. L. et al. Monocytes/macrophages control resolution of transient inflammatory pain. J. Pain 15, 496–506 (2014).Barthel, C. et al. Nerve growth factor and receptor expression in rheumatoid arthritis and spondyloarthritis. Arthritis Res. Ther. 11, R82 (2009).Skaper, S. D. Nerve growth factor: a neuroimmune crosstalk mediator for all seasons. Immunology 151, 1–15 (2017).Denk, F., Bennett, D. L. & McMahon, S. B. Nerve growth factor and pain mechanisms. Annu. Rev. Neurosci. 40, 307–325 (2017).Minnone, G., De Benedetti, F. & Bracci-Laudiero, L. NGF and its receptors in the regulation of inflammatory response. Int. J. Mol. Sci. 18, E1028 (2017).Bagal, S. K. et al. Discovery of potent, selective, and peripherally restricted Pan-Trk kinase inhibitors for the treatment of pain. J. Med. Chem. 61, 6779–6800 (2018).Pinho-Ribeiro, F. A., Verri, W. A. Jr & Chiu, I. M. Nociceptor sensory neuron-immune interactions in pain and inflammation. Trends Immunol. 38, 5–19 (2017).Robinson, W. H. et al. Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis. Nat. Rev. Rheumatol. 12, 580–592 (2016).de Lange-Brokaar, B. J. et al. Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review. Osteoarthritis Cartilage 20, 1484–1499 (2012).Rahmati, M., Mobasheri, A. & Mozafari, M. Inflammatory mediators in osteoarthritis: a critical review of the state-of-the-art, current prospects, and future challenges. Bone 85, 81–90 (2016).Urban, H. & Little, C. B. The role of fat and inflammation in the pathogenesis and management of osteoarthritis.Rheumatology 57, iv10–iv21 (2018).Dawes, J. M., Kiesewetter, H., Perkins, J. R.,Bennett, D. L. & McMahon, S. B. Chemokine expression in peripheral tissues from the monosodium iodoacetate model of chronic joint pain. Mol. Pain 9, 57 (2013).Driscoll, C. et al. Nociceptive sensitizers are regulated in damaged joint tissues, including articular cartilage, when osteoarthritic mice display pain behavior. Arthritis Rheumatol. 68, 857–867 (2016).Sweitzer, S. M., Hickey, W. F., Rutkowski, M. D., Pahl, J. L. & DeLeo, J. A. Focal peripheral nerve injury induces leukocyte trafficking into the central nervous system: potential relationship to neuropathic pain. Pain 100, 163–170 (2002).Hu, P., Bembrick, A. L., Keay, K. A. & McLachlan, E. M. Immune cell involvement in dorsal root ganglia and spinal cord after chronic constriction or transectionof the rat sciatic nerve. Brain Behav. Immun. 21, 599–616 (2007).Lems, W. F. Bisphosphonates: a therapeutic option for knee osteoarthritis? Ann. Rheum. Dis. 77, 1247–1248 (2018).Wenham, C. Y. et al. A randomized, double-blind, placebo-controlled trial of low-dose oral prednisolone for treating painful hand osteoarthritis. Rheumatology 51, 2286–2294 (2012).Dorleijn, D. M. J. et al. Intramuscular glucocorticoid injection versus placebo injection in hip osteoarthritis: a 12-week blinded randomised controlled trial. Ann. Rheum. Dis. 77, 875–882 (2018).McCabe, P. S. et al. Synovial fluid white blood cell count in knee osteoarthritis: association with structural findings and treatment response. Arthritis Rheumatol. 69, 103–107 (2017).Leung, Y. Y. et al. Colchicine lack of effectiveness in symptom and inflammation modification in knee osteoarthritis (COLKOA): a randomized controlled trial. Osteoarthritis Cartilage 26, 631–640 (2018).Kingsbury, S. R. et al. Hydroxychloroquine effectiveness in reducing symptoms of hand osteoarthritis: a randomized trial. Ann. Intern. Med. 168, 385–395 (2018).Lee, W. et al. Efficacy of hydroxychloroquine in hand osteoarthritis: a randomized, double-blind, placebo-controlled trial. Arthritis Care Res. 70, 1320–1325 (2018).Wenham, C. Y. et al. Methotrexate for pain relief in knee osteoarthritis: an open-label study. Rheumatology 52, 888–892 (2013).Kingsbury, S. R. et al. Significant pain reduction with oral methotrexate in knee osteoarthritis; results from a randomised controlled phase III trial of treatment effectiveness [abstract 428]. Arthritis Rheumatol. 70 (Suppl. 9), 454–455 (2018).Ridker, P. M. et al. Antiinflammatory therapy with canakinumab for atherosclerotic disease. N. Engl. J. Med. 377, 1119–1131 (2017).Kashyap, M. P., Roberts, C., Waseem, M. & Tyagi, P. Drug targets in neurotrophin signaling in the central and peripheral nervous system. Mol. Neurobiol. 55, 6939–6955 (2018).Bannwarth, B. & Kostine, M. Nerve growth factor antagonists: is the future of monoclonal antibodies becoming clearer? Drugs 77, 1377–1387 (2017).Baamonde, A., Lastra, A., Juarez, L., Hidalgo, A. & Menendez, L. TRPV1 desensitisation and endogenous vanilloid involvement in the enhanced analgesia induced by capsaicin in inflamed tissues. Brain Res. Bull. 67, 476–481 (2005).Hamilton, J. A., Cook, A. D. & Tak, P. P. Anti-colony- stimulating factor therapies for inflammatory and autoimmune diseases. Nat. Rev. Drug Discov. 16, 53–70 (2017).Schett, G. et al. A phase IIA study of anti-GM-CSF antibody GSK3196165 in subjects with inflammatory hand osteoarthritis [abstract 1365]. Arthritis Rheumatol. 70 (Suppl. 9), 1494 (2018).Achuthan, A. et al. Granulocyte macrophage colony-stimulating factor induces CCL17 production via IRF4 to mediate inflammation. J. Clin. Invest. 126, 3453–3466 (2016).Wylde, V., Hewlett, S., Learmonth, I. D. & Dieppe, P. Persistent pain after joint replacement: prevalence, sensory qualities, and postoperative determinants. Pain 152, 566–572 (2011).Beswick, A. D., Wylde, V., Gooberman-Hill, R., Blom, A. & Dieppe, P. What proportion of patients report long-term pain after total hip or knee replacement for osteoarthritis? A systematic review of prospective studies in unselected patients. BMJ Open 2, e000435 (2012).Li, H., Wang, R., Lu, Y., Xu, X. & Ni, J. Targeting G protein-coupled receptor for pain management. Brain Circ. 3, 109–113 (2017).

Brought to you by CSMi Providing accurate information on back pain seems to build confidence in the provider but doesn't seem to have a huge effect on outcomes. Is this really an improvement? In this episode, Erik and JW explore the role of the provider is these difficult cases. The Fear Reduction Exercised Early (FREE) approach to management of low back pain in general practice: A pragmatic cluster-randomised controlled trial. Darlow B, Stanley J, Dean S, Abbott JH, Garrett S, Wilson R, Mathieson F, Dowell A. PLoS Med. 2019 Sep 9;16(9):e1002897. doi: 10.1371/journal.pmed.1002897. eCollection 2019 Sep. To order the rheumatology booklet created by Jack March that we discussed on the podcast head to his website: https://rheumatology.physio/ Due to copyright laws, unless the article is open source we cannot legally post the PDF on the website for the world to download at will. That said, if you are having difficulty obtaining an article, contact us. Produced by: Matt Hunter Music for PT Inquest: "The Science of Selling Yourself Short" by Less Than Jake Used by Permission

Climate change impacts on health—including increased exposures to heat, poor air quality, extreme weather events, altered vector-borne disease transmission, reduced water quality, and decreased food security—affect men and women differently, depending on local geographic and socioeconomic factors. Climate change threatens to widen existing gender-based health disparities, especially in low- and middle-income countries. Health impacts, and gender differences in those impacts, are mediated through socioeconomic, cultural, and physiologic factors. Policy action targeted towards these factors, which are often modifiable, can decrease negative health outcomes. Integration of a gendered perspective into existing climate, development, and disaster-risk reduction policy frameworks requires improvement in data acquisition, monitoring of gender-specific targets, coordination between sectors, and equitable stakeholder engagement. Empowering women as educators, caregivers, holders of knowledge, and agents of social change can improve mitigation and adaptation policy interventions. Sorensen C, Murray V, Lemery J, Balbus J. Climate change and women's health: Impacts and policy directions. PLoS Med. 2018;15(7):e1002603. Published 2018 Jul 10. doi:10.1371/journal.pmed.1002603. This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. Sections of the Summary, Introduction, Health Imacts, and Conclusion are presented in the Podcast. Link to the full-text article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038986/

It is estimated that around 700,000 people die annually from drug-resistant infections,with experts predicting an alarming possible increase to 10 million deaths each year by 2050 and major future challenges to the way we practice medicine and surgery. Globally, there has been much emphasis on a ‘One Health’ approach that involves connecting the health of humans, animals, and the environment to tackle AMR. This is driving much needed antimicrobial stewardship (AMS) activities in animal production sectors. However, we have yet to achieve and establish joined-up approaches within human health. This paper, therefore, focuses on an analysis of multisectoral AMS in human health. AMS remains a cornerstone for addressing AMR with numerous initiatives implemented with varying degrees of success. Mcleod M et al. (2019) A whole-health-economy approach to antimicrobial stewardship: Analysis of current models and future direction. PLoS Med 16(3): e1002774. doi: 10.1371/journal.pmed.1002774. Link to the full-text article: https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1002774

To the extent that outcomes are mediated through negative perceptions of generics (the nocebo effect), observational studies comparing brand-name and generic drugs are susceptible to bias favoring the brand-name drugs. We used authorized generic (AG) products, which are identical in composition and appearance to brand-name products but are marketed as generics. Desai RJ et al. (2019) Comparative effectiveness of generic and brand-name medication use: A database study of US health insurance claims. PLoS Med. 16(3): e1002763. doi: 10.1371/journal.pmed.1002763.

Dr. Patrick and Clinical Manager Jordan Anderson run down the 10 most commonly prescribed medications in the US. The medication list can often feel like one more task that’s always partial and incomplete. Jordan and Dr. Patrick try to take a more detective-like approach to demonstrate the utility of anticipating side-effects and potential diagnoses based on medication list clues. References: 1. http://discovermagazine.com/2010/mar/07-dr-drank-broth-gave-ulcer-solved-medical-mystery 2. Gomes T, et al (2017) Gabapentin, opioids, and the risk of opioid-related death: A population-based nested case–control study. PLoS Med 14(10): e1002396

En el episodio de hoy comentamos un articulo recientemente publicado en PLOS Medicine sobre la transmisión sexual de Zika    Referencia: Michel Jacques Counotte y colaboradores. Sexual transmission of Zika virus and other flaviviruses: A living systematic review. PLOS Med.  Julio 24, 2018.   La Frase de la Semana:   Esta semana la tomamos de Samuel Johnson. Samuel Johnson, apodado Dr. Johnson, (nacido el 18 de septiembre de 1709 en Lichfield, Inglaterra y fallecido el 13 de diciembre de 1784 en Londres) fue crítico, biógrafo, ensayista, poeta y lexicógrafo inglés. Esta considerado como una de las más grandes figuras de La vida y las letras inglesas del siglo XVIII.   La frase dice:  “Se puede tener por compañera a la fantasía, pero se debe tener como guía a la razón”  

Fainting spells are surprisingly common. Even among United States Marines. This week we explore the mechanisms underlying loss of consciousness in your every day patient. And your every day soldier. Produced by James E. Siegler. Music by Jason Shaw, Andy Cohen, Kai Engel, and Josh Woodward. BrainWaves' podcasts and online content are intended for medical education only and should not be used for clinical decision making. REFERENCES Freeman R. Clinical practice. Neurogenic orthostatic hypotension. The New England journal of medicine. 2008;358:615-24. Grubb BP. Neurocardiogenic syncope and related disorders of orthostatic intolerance. Circulation. 2005;111:2997-3006. Wolters FJ, Mattace-Raso FU, Koudstaal PJ, Hofman A, Ikram MA and Heart Brain Connection Collaborative Research G. Orthostatic Hypotension and the Long-Term Risk of Dementia: A Population-Based Study. PLoS Med. 2016;13:e1002143. Sonnesyn H, Nilsen DW, Rongve A, Nore S, Ballard C, Tysnes OB and Aarsland D. High prevalence of orthostatic hypotension in mild dementia. Dement Geriatr Cogn Disord. 2009;28:307-13.

Tue, 18 Oct 2016 10:45:57 +0000 https://evidenzbasierte-pharmazie.podigee.io/34-ebpharm-magazin-im-oktober 3251f0181da862954b0650694641f9b9 In der Rubrik „Evidenzbasierte Pharmazie in der Praxis“ gibt es wieder Hinweise zu verfügbaren evidenzbasierten Informationen, die sich besonders gut für die Beratung in der Selbstmedikation nutzen lassen. Neues gibt es bei medizin-transparent und im Patientenportal des IQWiG. In unserer Reihe zu systematischen Übersichtsarbeiten geht es dieses Mal um Meta-Analysen auf der Basis von individuellen Patientendaten. Und weitere interessante Neuigkeiten finden Sie im Blick „Über den Tellerrand“. Die ShowNotes und noch mehr Hintergrundinformationen gibt es auf meinem Blog. Links zu evidenzbasierten Informationen für die OTC-Beratung Medizin-transparent: Artischocken-Präparate bei Verdauungsbeschwerden Medizin-transparent: Nutzen von Zahnseide IQWiG-Patienteninformation zum Reizdarmsyndrom Links zu "Evidenzbasierte Pharmazie auf den Punkt" (systematische Reviews) Tierney et al. Individual Participant Data (IPD) Meta-analyses of Randomised Controlled Trials. PLoS Med 2015; 12(7): e1001855 Hintergründe zu Tamiflu und dem Cochrane Review im BMJ Tudur Smith et al. Individual participant data meta-analyses compared with meta-analyses based on aggregate data. Cochrane Database Syst Rev. 2016 Sep 6;9:MR000007 Cochrane Handbook Kapitel 18: Reviews of individual patient data Links zu "Über den Tellerrand" Evidenz-Sprechstunde zu Real World Data "Werbung aufgepasst" in Gute Pillen - Schlechte Pillen Musik Ausschnitte aus „I dunno“ von grapes, unter CC BY 3.0 Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International Lizenz. 34 full no Dr. Iris Hinneburg

David and Tamler tackle three topics on their last double digit episode. First, should a middle school perform "To Kill a Mockingbird" even if they have to use bad language the "n-word," and talk about sexual assault? Tamler relates a story involving his daughter (who was supposed to play Scout) and a playwright who refused to allow his play to be censored. But when it comes to drama, middle school's got nothing on social psychology. Next, David and Tamler break down the latest controversy surrounding Princeton psychologist Susan Fiske's leaked column about the bullying destructo-critics and methodological terrorists that are challenging the establishment in the field. Finally, they give a spoiler-filled analysis of season 2 of Mr. Robot, a polarizing season for many fans. Tamler's suffering from a little theory fatigue, but David blows his mind with his explanation of what's really going on with the Dark Army and F-Society. Have you ever cried during sex?LinksTo Kill a Mockingbird stage play [stageagent.com]Mob Rule or the Wisdom of Crowds? Susan Fiske's forthcoming column in the APS Observer [verybadwizards.com]Andrew Gelman's blog post about Susan Fiske's column [andrewgelman.com]Ioannidis, J. P. (2005). Why most published research findings are false. PLoS Med, 2(8), e124. [plos.org]The Hardest Science blog by Sanjay Srivastava (@hardsci)sometimes i'm wrong blog by Simine Vazire (@siminevazire)The 20% Statistician blog by Daniel Lakens (@lakens)Too Many Cooks [youtube.com]Bitcoin explained and made simple [youtube.com]Key generation [wikipedia.org]