Podcasts about Dictum

In the second hour of The Rita Cosby Show, Lionel chats about Hickam's Dictum and dives into the joys of YouTube videos. He talks stolen valor videos to Karen's being arrested and everything in between. Learn more about your ad choices. Visit megaphone.fm/adchoices

Class on Vivekachudamani on 20 February 2025 by Swami Sunishthananda.BankDetails for Donations:CBAA/C Name: Vedanta CentreBSB 06 3159A/C: 1056 1620 Onlineclass talk links: YouTube Link https://www.youtube.com/channel/UCNzjwJ9X5QOY6NnOtrL45KA/ Available Listening Platforms Anchor https://anchor.fm/swami-sunishthanandaBreaker https://www.breaker.audio/vedanta-melbourne-classesPodcasts https://www.google.com/podcasts?feed=aHR0cHM6Ly9hbmNob3IuZm0vcy8yZGUyMTRlMC9wb2RjYXN0L3Jzcw==Overcast https://overcast.fm/itunes1526036863/vedanta-melbourne-classesPocket Casts https://pca.st/q0859ok9Radio Public https://radiopublic.com/vedanta-melbourne-classes-G1PBQ4Spotify https://open.spotify.com/show/4N1MLlU3dfRvPUdz7xqY9l For more information visit https://www.vedantamelbourne.org/

Class on Vivekachudamani on 13 February 2025 by Swami Sunishthananda.BankDetails for Donations:CBAA/C Name: Vedanta CentreBSB 06 3159A/C: 1056 1620 Onlineclass talk links:YouTube Linkhttps://www.youtube.com/channel/UCNzjwJ9X5QOY6NnOtrL45KA/ Available Listening PlatformsAnchorhttps://anchor.fm/swami-sunishthanandaBreakerhttps://www.breaker.audio/vedanta-melbourne-classesPodcastshttps://www.google.com/podcasts?feed=aHR0cHM6Ly9hbmNob3IuZm0vcy8yZGUyMTRlMC9wb2RjYXN0L3Jzcw==Overcasthttps://overcast.fm/itunes1526036863/vedanta-melbourne-classesPocket Castshttps://pca.st/q0859ok9Radio Publichttps://radiopublic.com/vedanta-melbourne-classes-G1PBQ4Spotifyhttps://open.spotify.com/show/4N1MLlU3dfRvPUdz7xqY9l For more information visit https://www.vedantamelbourne.org/

Class on Vivekachudamani on 06 February 2025 by Swami Sunishthananda. Bank Details for Donations: CBA A/C Name: Vedanta Centre BSB 06 3159 A/C: 1056 1620   Online class talk links: YouTube Link https://www.youtube.com/channel/UCNzjwJ9X5QOY6NnOtrL45KA/   Available Listening Platforms Anchor https://anchor.fm/swami-sunishthananda Breaker https://www.breaker.audio/vedanta-melbourne-classes Podcasts https://www.google.com/podcasts?feed=aHR0cHM6Ly9hbmNob3IuZm0vcy8yZGUyMTRlMC9wb2RjYXN0L3Jzcw== Overcast https://overcast.fm/itunes1526036863/vedanta-melbourne-classes Pocket Casts https://pca.st/q0859ok9 Radio Public https://radiopublic.com/vedanta-melbourne-classes-G1PBQ4 Spotify https://open.spotify.com/show/4N1MLlU3dfRvPUdz7xqY9l   For more information visit https://www.vedantamelbourne.org/

The topic of UFOs is maturing now as those who analyze the subject seriously consider the implications of national security, religion, and science. UFO investigators like Dr. Steven Greer are positive there will be a full disclosure very soon – the future has never looked brighter. High-level disclosure of UAP information could also transform our understanding of history, physics, and the universe. The reality of upcoming UAP revelations extends beyond scientific advancement. They challenge our understanding of human history, governance, and humanity's place in the universe. If this comes to fruition, how will you respond? Tonight on Ground Zero, Clyde Lewis talks with MUFON Director of Southern California, Earl Grey Anderson, about DICTUM X. Listen Live: https://groundzero.radio Archived Shows: https://aftermath.media

I know a lot of Daves, and many of them have been on my podcast. With that in mind they're helping me celebrate a new holiday, Davecember, when each of them joins for me a mini-episode sprinkled randomly this month into your feed. I'll ask each of them similar questions, and each David also gets a bit of time to bring up something they want to share with my listeners. Enjoy! Please join us on the Boardgames To Go discord server where you can chat online with other podcast listeners.       David Corbin joins us next, doubling our count of North Carolina based Davids...but he's not our last. He comes offering David's Aphorism, as well as David's Dictum. Heady stuff... -Mark

Wir wünschen euch einen wunderbaren ersten Advent! Und haben – neben dem Start unseres Adventskalenders viele good News zu verkünden! Nein, ihr habt keine Folge verpasst – wir haben im November einfach nicht geschafft, eine hochzuladen. Denn: Zuerst war ich krank und stimmlich ziemlich angeschlagen. Gleichzeitig haben sich hier die Dinge überschlagen... ! Eine News muss leider noch etwas warten. Kleiner Hint: Wir waren beim Notar. Mehr gibt's dann im Januar! :) Eine weitere News hat uns auch ordentlich beschäftigt: Wir haben ein neues Baby. Also kein menschliches. Sondern ein neues Angebot, nämlich unser Gartencoaching! In unserer neuesten Podcast-Episode verraten wir euch alle Details. Hört doch gern mal rein: Links zur Podcast-Episode Ihr wollt euch mal bei den Landlust-Webinaren umschauen? Dann tut das nur zu gern!

Conference on Angels: Conf. #1: The Role Of Our Guardian Angels is More Than A Protector When we hear that expression, Guardian Angels, we imagine those angels who individually have been assigned to watch over us. And that's a half truth. Rather, when the church celebrates the guardian angels, it celebrates that, but it also celebrates the way that angels are the guardians of the people of God in a broader sense. And so, for example, for hundreds and hundreds of years as the guardian angels are celebrated, the church leads with the image of the angel. The Lord Guards and Guides His People by Means of the Angels The angel watches over the Hebrews as they are led out of Egypt. And note how that's not individual guardianship, but very real guardianship. And note also what it is. It is not merely protection. When we speak of the angels as guardianship, guardians and the way the Lord guards and guides his people by means of the angels, we recognize several things. Note, the prayer emphasizes guardian, not protector. How does the guardian guide us? Before it is protection, it is guidance. Before it is defending, it is instructing. That's why at mass today we hear that very clear Dictum on the part of the Almighty as he speaks to the people. I will put my angel to watch over you. Be careful to listen to him. Note the thrust of that, the angels guard us not simply by keeping us safe from physical danger, but by helping us to find the right path and the right way. Hear the role of Guardian Angels in our lives and how they help us! Listen to this first of two conferences. Listen to: The Role Of Our Guardian Angels is More Than A Protector ----------------------------------- Image: Our Guardian Angels: Artificial Intelligence (AI) Platform: Generative AI Image by Queen of All Hearts What is Generative AI? Generative AI refers to a recent approach in artificial intelligence that involves the creation of AI-generated art. This innovative technique utilizes a potent AI computer to generate images based on textual prompts or instructions. The resulting output is an AI-generated image, representing one interpretation of a given concept, such as Our Guardian Angels in this particular instance. ----------------------------------- Conference #2 on Angels will be made available shortly.

She did it! Judge Aileen Cannon dismissed the Mar-a-Lago case. She bought Justice Clarence Thomas's drive-by concurrence in the immunity ruling saying Jack Smith was appointed unconstitutionally.Jack Smith has requested permission from Merrick Garland to appeal Cannon's ruling. Questions for the pod Submit questions for the pod here https://formfacade.com/sm/PTk_BSogJ Brian Greer's Quick Guide to CIPAhttps://www.justsecurity.org/87134/the-quick-guide-to-cipa-classified-information-procedures-act/ AMICI CURIAE to the District Court of DC https://democracy21.org/wp-content/uploads/2023/08/Attachment-Brief-of-Amici-Curiae-in-Support-of-Governments-Proposed-Trial-Date.pdfGood to know:Rule 403bhttps://www.law.cornell.edu/rules/fre/rule_40318 U.S. Code § 1512https://www.law.cornell.edu/uscode/text/18/1512 Prior RestraintPrior Restraint | Wex | US Law | LII / Legal Information InstituteBrady MaterialBrady Rule | US Law |Cornell Law School | Legal Information Institutehttps://www.law.cornell.edu/wex/brady_rule#:~:text=Brady%20material%2C%20or%20the%20evidence,infer%20against%20the%20defendant's%20guiltJenksJencks Material | Thomson Reuters Practical Law Glossaryhttps://content.next.westlaw.com/Glossary/PracticalLaw/I87bcf994d05a11e598dc8b09b4f043e0?transitionType=Default&contextData=(sc.Default)Gigliohttps://definitions.uslegal.com/g/giglio-information/Statutes:18 U.S.C. § 241 | Conspiracy Against Rights18 U.S.C. § 371 | Conspiracy to Defraud the United States | JM | Department of Justice18 U.S.C. § 1512 | Tampering With Victims, Witnesses, Or Informants Questions for the pod Submit questions for the pod here https://formfacade.com/sm/PTk_BSogJCheck out other MSW Media podcastshttps://mswmedia.com/shows/Follow AGFollow Mueller, She Wrote on Posthttps://twitter.com/allisongillhttps://twitter.com/MuellerSheWrotehttps://twitter.com/dailybeanspodAndrew McCabe isn't on social media, but you can buy his book The ThreatThe Threat: How the FBI Protects America in the Age of Terror and TrumpWe would like to know more about our listeners. Please participate in this brief surveyListener Survey and CommentsThis Show is Available Ad-Free And Early For Patreon and Supercast Supporters at the Justice Enforcers level and above:https://dailybeans.supercast.techOrhttps://patreon.com/thedailybeansOr when you subscribe on Apple Podcastshttps://apple.co/3YNpW3P

Cranial neuralgias comprise a distinct set of disorders typified by short-lasting attacks of intense pain in the distribution of a particular nerve in the cranium. Cranial neuralgia syndromes are rare but can be debilitating and go undiagnosed or misdiagnosed for years. In this episode, Lyell Jones, MD, FAAN, speaks with Stephanie J. Nahas, MD, MSEd, FAAN, MD, an author of the article “Cranial Neuralgias,” in the Continuum® April 2024 Headache issue. Dr. Jones is the editor-in-chief of Continuum: Lifelong Learning in Neurology® and is a professor of neurology at Mayo Clinic in Rochester, Minnesota. Dr. Nahas is an associate professor of neurology at Thomas Jefferson University and assistant director of the Headache Medicine Fellowship Program at Jefferson Headache Center in Philadelphia, Pennsylvania.   Additional Resources Read the article: Cranial Neuralgias Subscribe to Continuum: continpub.com/Spring2024 Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Host: @ LyellJ Guest: @stephanieJnahas Full transcript available here  Dr Jones: This is Dr. Lyell Jones, Editor-in-Chief of Continuum, the premier topic-based neurology clinical review and CME journal from the American Academy of Neurology. Thank you for joining us on Continuum Audio, a companion podcast to the journal. Continuum Audio features conversations with the guest editors and authors of Continuum, who are the leading experts in their fields. Subscribers to the Continuum journal can read the full article or listen to verbatim recordings of the article by visiting the link in the show notes. Subscribers also have access to exclusive audio content not featured on the podcast. As an ad-free journal entirely supported by subscriptions, if you're not already a subscriber, we encourage you to become one. For more information on subscribing, please visit the link in the show notes. AAN members, stay tuned after the episode to hear how you can get CME for listening.    Dr Jones: This is Dr. Lyell Jones, Editor-in-Chief of Continuum: Lifelong Learning in Neurology. Today, I'm interviewing Dr. Stephanie Nahas, who has recently authored an article on cranial neuralgias in the latest issue of Continuum on headache. Dr. Nahas is a neurologist at Thomas Jefferson University where she is an Associate Professor of Neurology and serves as Assistant Program Director of the Headache Fellowship program there. Dr. Nahas, welcome, and thank you for joining us today. Dr Nahas: Thanks for having me. Glad to be here. Dr Jones: So, for our listeners who are new to Continuum, Continuum is a journal dedicated to helping clinicians deliver the highest possible quality neurologic care to their patients, and we do so with high quality and current clinical reviews. Dr. Nahas, your article is a perfect example of that - it's full of really helpful (and I think clinically relevant) recommendations for neurologists who take care of patients with cranial neuralgias. And now that at this moment (during this podcast interview), you have the attention of a huge audience of neurologists - what's the one most important practice change that you would like to see in the care of these patients?  Dr Nahas: I would like to see the recognition of these cranial neuralgias and related syndromes as distinct and overlapping with other primary headaches much more often. I think far too often, clinicians will try to pigeonhole these headache and facial pain diagnoses and try to make just one diagnosis the main one, and any other symptomatology that comes along with it – “Oh, that's just a weird part of your primary syndrome, right?” I know I've fallen into this trap a number of times, because mostly what we see in a headache clinic is going to be migraine, so we kind of have a laser focus towards migraine-type symptoms (and we know migraine can do just about anything). So then when we hear a little bit about a facial pain, a little bit about some sort of neuralgia, we just try to wrap it up into migraine - but that's not always necessarily the case. You know, we know that any person on the planet can have as many diseases as they darn well please, so why not ascribe two diagnoses when it's appropriate? That can lead to better treatment outcomes, in fact. If you are focusing your treatment on two distinct, but overlapping, entities, you tend to get better results, because the treatments may not be identical (and they rarely are). Dr Jones: And that's a great example of it's Occam's razor on one side (there's one problem) versus - what is it, Hickam's Dictum? Dr Nahas: Something like that. Dr Jones:  - where you can have as many problems as the patient wants to have, so I think that's a great example of that. And, earlier, in the same issue on headache, we do have a wonderful article by Dr. Deb Friedman, who walks through that really important history component of trying to, you know, determine which headache syndrome the patient is dealing with (which is obviously a prerequisite for the diagnosis and management) - so that's a great point. So that's the one takeaway - recognition of cranial neuralgias as a distinct entity. Keep it in mind – otherwise, we'll miss it. Is that right? Dr Nahas: You got it. Dr Jones: Okay, good. If we learn nothing else, we'll take that away. So, speaking of the history, Dr. Nahas, for many pain syndromes (including these), the history is really paramount in establishing the diagnosis for patients, specifically with trigeminal neuralgia. How do they usually describe that pain to you?  Dr Nahas: The whole spectrum of descriptors for trigeminal neuralgia-form pain is, actually, maybe broader than you would think, and I actually find that, sometimes, patients have a real hard time verbalizing and describing the way it feels, because it's so unusual - it doesn't remind them of anything they've necessarily felt before.  Sometimes, it can. For example, a patient who's no stranger to having lots of dental work - that pain that when they drill in or if they hit an irritated part of the tooth or the gums, that's usually kind of neuralgia form-like. But at the same time, patients will say, “It's still not quite like that. You know, it's really hard for me to explain. It's sharp and it's terrible like that, but it has a different quality.” And I think they just don't necessarily have the terminology, but I encourage them to try to be creative. You know, some of my patients will personify the pain - they'll describe as if there's some little creature in there that's clawing, or scraping, or pulling, or stabbing. Or they might use other descriptors, such as burning like a fire (like a blow torch is there). Or they may even use colors. You know, some of my patients are really creative, and I don't know if they actually have synesthesia or they're just bordering on that, but they'll describe different colors for the qualities of pain. (“Is it more red? Is it more like icy blue? Is it black or white?”) I don't hear that too often, but I do like to just open the door and let my patients describe for themselves in their own words - and if they can't have any words, I give them some examples and that usually gets the ball rolling. Dr Jones: So, a combination (like we usually do) with some open-ended questions, and then some directed ones to kind of clarify. That's really interesting, and it gives you some immediate empathy and sympathy for the discomfort these patients have to deal with, right (as when they describe it in those burning, clawing kind of terms)? Dr Nahas: Exactly, and they'll also put it into context for you - so not just describing what the quality of the pain is like, but they'll give you good examples of when they feel these symptoms, what brings them on, what alleviates them, how the symptoms may change from day to day depending on the situation or circumstance. And again, it just gives them an open door to express themselves, and it really does help to strengthen that alliance you're trying to create and maintain with your patient. You do get useful and valuable information when you just let them go on and describe things. Dr Jones: So, there are, I think, misconceptions in the popular world and also in the clinical side of care that, you know, folks will have a perception of a disorder that maybe doesn't really match reality. What do you think is a common misconception you've encountered in taking care of patients with cranial neuralgias?  Dr Nahas: The patients that I see tend not to have the clear-cut textbook descriptions  (like it's almost as if they're reading the criteria when they tell you your symptomatology) - because those cases are a little bit easier, they get identified more readily, they get appropriate treatment sooner, their disease doesn't necessarily progress and become complicated by, you know, any number of things that can happen with unmanaged neuralgia-form craniofacial pain. The ones that I see - they've been around the block several times, because maybe their syndrome isn't quite so typical. Maybe they didn't really have the terminology to be able to describe their symptoms. Maybe nobody really opened that door for them and invited them to just talk about what it is. Perhaps they, or whoever they were seeing, were more focused on diagnostic testing, and so their focus is more on, “Why is my MRI not showing anything? Why is my x-ray completely normal? You know, I have these symptoms. There must be an explanation.” Because that's what patients want - they want solutions. They have a problem, they want to know why they have it, and they want a solution to it. And they can get too focused on the hard data and ignore that it's a subjective experience that really guides us to help treat their symptoms, especially when we don't have necessarily an anatomic target to go after. (When we do, that's great.) But again, these straightforward cases tend not to come to me, because they're easier to take care of. Dr Jones: Still, just as legitimate a diagnosis, even with a normal MRI, right? I do find it's sometimes hard to kind of get around that with a patient, isn't it? Dr Nahas: Absolutely, it is. You know, they're both relieved and disappointed. I often find if we order imaging for an unusual syndrome (or even a typical syndrome) and they see that, “Well, there's nothing on this report to go for. What does that mean? Does that mean that I'm crazy? Does it mean that this is all in my head, that I'm imagining it, that I'm amplifying my symptoms somehow? Is this my fault?” You know, all this self-doubt comes in, and you have to reassure these patients that, “Yes, your symptoms are real. They are in your head, because your brain is in your head, and your brain is the source of your perception and your experience. So, let's take your symptoms at face value and let's give you treatments that are directed at those symptoms.” Dr Jones: Well said, and that's where we like to keep it, the brain inside the head. I think that was day one of neuroanatomy. I know that the treatment for many of these cranial neuralgias overlaps, right? There's some common approaches to several of these. There are some things that we put in our academic writing, but there are some things that we just kind of learn from experience. Do you have any tips or tricks that you would like to share with our listeners about the management of the cranial neuralgias?  Dr Nahas: First and foremost (and I think this kind of goes for any of the disorders in the spectrum of headache and facial pain) is you need to be patient, and you need to set up appropriate expectations that, by and large, this is a trial-and-error process where we need to introduce a therapeutic intervention gradually and titrate the dose gently to effect while following for clinical response, but also keeping an eye on what our guardrails are. What do I mean by that? Let's say, for example, we're using oxcarbazepine for some sort of neuralgia-form disorder (I mean, take your pick for any of them – it's fair game for most of these as a good initial trial). Dr Jones: Sure. Yeah. Dr Nahas: So, you want to start it at a low dose, start building it up slowly, and in addition to following for their clinical response - which I counsel them it may take a while  (even once we hit a target dose, it may take several more weeks, we've got to give it time) - you can monitor a serum level of oxcarbazepine and certain other antiseizure medicines for that matter. So, that can help guide you to know how high you can go. This is a little bit different from the situation with epilepsy, where you're checking levels to ensure that it's in a therapeutic range to make sure that it's not toxic - maybe to assess for adherence - but here, we're using it as a guide to know how much farther can we push the dose on this drug. And, of course, also, you want to be monitoring for any adverse events that can occur with that drug (such as hyponatremia, or changes in the CBC, et cetera) - so I do monitor these folks a little bit more closely than I otherwise ordinarily would, especially when I have a therapeutic intervention where I can actually monitor the drug level of it and be very, very precise in trying to maximize and optimize their treatment. Dr Jones: Got it. So, patience with each trial, and then patience that there might be (and I mean patience with a ‘c' that there might be) multiple trials – I think that's a good takeaway for all of these cranial neuralgias with pretty much all of the medication treatments, right? Dr Nahas: Yes, and I do find that in some cases, one treatment is not quite enough. Because most of the treatments we draw from our antiseizure medication category, it can get complex trying to balance two, or even three, antiseizure medicines and finding the optimal dose for each. Do we push all of them to the max? Do we say this one is the undercurrent (we just want to keep it at a low level) and these other two are going to be doing the lion's share of the work? It becomes kind of fun if you like uncertainty and if you like to be creative. If you're the type of person who likes checkboxes and checklists and cut and dried results, you know this is not the game that you want to play - but that's one of the reasons that I enjoy doing this, because I have so much freedom to be creative and really finely tailor and tune the treatment specifically to the individual patient's needs. Dr Jones: That's fantastic, and in a minute, I think we can come back to maybe what drew you to this - I'm curious to hear that. But before we get to that, you know, when we think about the medications that are available (and again, your article does a phenomenal job summarizing the therapeutic approaches to the cranial neuralgias) - what do you see on the horizon, Dr. Nahas, for the care of these patients?  Dr Nahas: I want to see a lot more research being done in this population of patients and across this spectrum of disorders. What makes it so hard is because they are somewhat rare, and because they very often co-occur with another primary headache disorder - so that makes it extraordinarily difficult to create a research study on a population that's so heterogeneous, right? That's, I think, the biggest challenge - is that we have so little to guide us other than our own clinical experience. There are not a ton of clinical trials for any of these disorders. I think one in particular that can be both underdiagnosed and overdiagnosed is occipital neuralgia - and I mentioned before that I, myself, have found myself falling into this trap of once I see a signal for migraine, I just call everything migraine, right? And, sure, with migraine, there can be allodynia in the scalp, and oh, sure, we all hear that if you push on something sore, you can have some lancinating pain. Oh, that occipital neuralgia that somebody told you about? No, no, that's just part of your migraine. You don't actually have occipital neuralgia. Well, you know, if you look at clinic-based studies (there's one in particular that I cited), most of the presentations of occipital neuralgia actually co-occurred with another headache diagnosis (either primary or secondary), and very commonly, it was migraine or probable migraine or chronic migraine. And why this is important is because you need to validate for these patients that they do have more than just migraine. They have a separate problem that, yes, it's interrelated, it's interconnected, they can influence each other - but we might have to treat them both differently. So, you have your suite of migraine treatments which might not include an antiseizure medication. Then, for the occipital neuralgia, maybe you are pulling in an antiseizure medication, or maybe you're focusing more on peripheral nerve blockade or physical therapy - or even considering a surgical referral, because as surgical treatments for nerve decompression or ablation or other interventional procedures also continue to evolve, that helps to give us some more hope in giving  these patients more relief with fewer complications. I'd also like to see some more creative solutions, not just more antiseizure medicines, not just more targeted anatomic interventions. But, hey, is there a role for some other peptides or neurotransmitters that we just haven't identified yet? Might some novel treatment approaches actually be useful for some of these patients? And, you know, again, how do we get at those answers? It's going to be challenging, because the patients - while they're out there, they're not really a homogeneous group, and the results from a particular study might not be so generalizable. Dr Jones: And we've seen such great success in the world of migraine, right (looking for novel targets) And so it would be nice to transport that over to the cranial neuralgias, right? Dr Nahas: Yes, absolutely. Dr Jones: Yeah. We should always be mindful of disparities in care of patients who have neurological problems. Are you aware of any literature around the care of these patients related to health care disparities that our listeners should be aware of? Dr Nahas: Nothing focused specifically on disparities in this population or subpopulations within this population (based, for example, on ethnicity, or race, or socioeconomic status). You're looking for subpopulations within a huge population, almost like a needle in a haystack - not quite that difficult, but again, it takes a lot of effort and diligence to try to find these individuals and then to get them to agree to enroll in some sort of research study, even if it's just a survey study or doing interviews with them trying to understand their symptomatology better. It can be quite challenging. And then again, let alone designing a rigorous clinical trial for these folks - who, again, such a heterogeneous presentation - and the willingness to participate in a placebo-controlled trial for pain that can be so heinous can be very, very challenging. You know, we've seen this as a challenge with cluster headache, too - not just because of the nature of the disease (when the cycles come and go somewhat unpredictably). But these folks aren't necessarily willing to forgo treatment for the purposes of a clinical trial - I mean, many are, and I thank them - this is another one of the reasons that research is really lacking in some of these rarer syndromes. Dr Jones: So, another part of the rationale for more investigation for these uncommon and probably underserved disorders. So, Dr Nahas, I know caring  for patients with craniofacial pain, I imagine it can be challenging. I can imagine it's also pretty rewarding as well. What drew you to this work, and what do you find most exciting about it?  Dr Nahas: Well, what brought me to headache to begin with was kind of random chance, and really, it revolves around mentorship. When I very first started as a neurology resident, Dr. Silberstein took me under his wing and wanted to turn me into a headache specialist (that was one of his goals). And, thankfully, he was successful, although he didn't really have an easy job of it, because back then, I didn't really see or understand how studying headache and facial pain could really satisfy that hunger that I have to understand the brain and the nervous system. I mean, that's why I became a neurologist in the first place, right? (I think that's why most of us did.) You know, not only are we drawn to medicine to help people and be altruistic and to study a fascinating topic, but particularly with the brain and the nervous system - I mean, this is what makes us human. This is what's so fascinating to me. And until I started to learn more about headache, I thought the best way to really learn about brain function is through disease (such as stroke or epilepsy, or movement disorders, cognitive disorders, degenerative disorders). This is how we learn, right? This is what I was taught, at least in college and med school. And then you get to the real world of actually practicing medicine or being in training. You start talking with these folks, and you hear their stories and how distinct they are from the textbooks. And again, when you invite them to really describe their experience, you see the human side of it, and you listen to them describe their symptoms - and you start to imagine yourself, what's really going on in their brain and their nervous system for them to experience that? So you start reading a lot of the literature about cortical spreading depolarization and how that can activate the trigeminal system and sensitize it - how that might be linked to the expression of aura (for example) - then, you can actually really parse out the anatomy and understand why somebody experiences those symptoms when you understand the anatomy. And there are just countless examples of this - about how studying the symptoms and what brings them about, what the pathophysiology is, and then what the treatment is, how that really informs our understanding of how the brain functions - that's really what's kept me excited about this. That, and again, forming relationships with patients and sometimes being the first person who ever just sat down and listened to them and let them talk, and they really feel like they're cared about and like they're important - because they are. I think far too often, patients with headache and facial pain disorders are stigmatized, and they're left feeling like it's not worth it trying to get better, that there is no solution. Society has beat them down, the medical system has let them down, and they just want to give up. Then, when we can finally sit and listen and give them some hope, and they see some improvement - the transformation that occurs right before your eyes is extraordinarily gratifying. Dr Jones: So, it's fascinating, and you can help people - and I can't think of a better advertisement for headache fellowship for all those neurology trainees out there.  Well said, Dr Nahas. So I've got one more question for you before we close. And I know that the headache community, including yourself, are very strong advocates for your patients and for more research (as we've talked about today) into headache disorders, understanding the pathophysiology, developing better treatments. What is it about purple hair? I've seen several headache specialists (and maybe someone on this call) post online some purple hair. What's the story behind that? Dr Nahas: A number of years ago, as part of advocacy efforts, we recognized there's got to be a way to really improve the awareness of such a common condition, of headache in general. It affects so many people, it almost becomes, again, brushed off. We say headache, it's just a nuisance. Well, no it's not. It's actually fascinating as part of the human condition. One of the things we needed was a color - our signature color - and we chose purple. We know that we share this color with other advocacy groups, but it's a great color, it's eye-catching, and you can utilize it in a number of different ways. One of the early ways was people dressing up in all kinds of purple garb - putting purple makeup on, purple sunglasses, purple tutus, purple T-shirts, and even purple wigs. A lot of us have been donning purple wigs for advocacy and for awareness efforts, particularly for events (such as Miles for Migraine, for example) - but some of us have been so bold as to not just put on a purple wig, but to actually go to a salon, bleach the hair, and dye it bright purple. I have at least one male colleague who also did this to his beard. Last year, we did it together at the same salon, took a bunch of pictures to post about. It really created a big splash online and for our social media efforts and outreach, and it caught on. Lots more people now are thinking about dying their hair purple. One of our current fellows actually did it this year. At our center, we have about 30 different purple wigs that we bought with some funds that we procured, and on the Shades for Migraine Day (June 21), we all went out parading around Center City, Philadelphia wearing our purple T-shirts and our purple wigs, and handing out flyers trying to raise awareness. We got a lot of strange looks, but we also got a lot of good feedback. And I think we actually reached some people who didn't realize that there's such a thing as a headache center that they could actually come and see us and get relief for this problem they thought was just a part of everyday life. That was kind of a long-winded answer, but - Dr Jones: No, that's great, and it worked. It got me to ask you about it, right? And I will say I admire your commitment and dedication. The best I could do today, Dr Nahas, was wear a purple tie, but I'm sure your patients appreciate that level of investment, too. It's really, really cool. Really impressive. Dr Nahas: Yeah. A lot of them this past year have asked me, “Where's the purple hair? I thought you were going to do it every year around this time.” And, you know, it is a bit of a commitment. Dr Jones: It's a commitment, yeah. Dr Nahas: And there's some upkeep that is required and you're kind of stuck with it for a while (unless you want to go to the trouble of reversing the process, but that's really just covering it up). I said, "We've moved beyond dying the hair. We're doing wigs, and we're thinking of the next thing.”  Dr Jones: Good for you. Dr Nahas, thank you so much for joining us, and thank you for such a thorough and fascinating discussion on symptomatic management of cranial neuralgias and such a wonderful article in the latest issue of Continuum.  Really appreciate you being here today. Dr Nahas: I can't thank you enough. It's been my pleasure.   Dr Jones: Again, we've been speaking with Dr Stephanie Nahas, author of an article on cranial neuralgias in Continuum's most recent issue on headache. Please check it out, and thank you to our listeners for joining today.  Dr Monteith: This is Dr. Teshamae Monteith, Associate Editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal which is full of in-depth and clinically relevant information important for neurology practice - and right now, during our Spring Special, all subscriptions are 15% off. Go to Continpub.com/Spring2024, or use the link in the episode notes to learn more and take advantage of this great discount. This offer ends June 30, 2024. AAN members, go to the link in the episode notes and complete the evaluation to get CME. Thank you for listening to Continuum Audio.

Indie author Frederick Gero Heimbach joins the show to discuss his first novel, The Devil's Dictum. This is a story unlike anything you've read before. This is an alternate America founded by evil, satanic pirates where Richard Nixon is one of the good guys in a giant robot suit. If that doesn't grab your attention, then I can't help you. Twitter: @Fredosphere Author Website: https://www.fheimbach.com/ Author's Books Mentioned: The Devil's Dictum Ronald Reagan's Brilliant Bullet Buckingham Runner More Christian speculative fiction: Mysterion Online Silence & Starsong ************************************************************************************************************* Follow me on Twitter @AaronIrber Donate to my Patreon - I Might Believe in Faeries https://www.patreon.com/imightbelieveinfaeries Like my Facebook page - I Might Believe in Faeries Battle Of The Creek by Alexander Nakarada | https://www.serpentsoundstudios.com Music promoted by https://www.free-stock-music.com Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/ Logo Art by Linnea Kisby *************************************************************************************************************

Hoge Raad 1 maart 2024 ECLI:NL:HR:2024:298 (Hobo Holding / Rabobank)Hobo Holding vorderde in deze zaak een verklaring voor recht en schadevergoeding, vanwege het opzeggen van een financieringsovereenkomst door de Rabobank. Het hof wees die vorderingen toe, zowel voor Hobo als voor haar rechtsvoorgangsters.  Het hof is niet ingegaan op het verweer van de Rabobank dat voor toewijzing van de vorderingen van de rechtsvoorgangers geen plaats is. De Hoge Raad vernietigt het arrest en doet de zaak zelf af. Hidde Volberda bespreekt dit arrest.Ga naar https://cassatieblog.nl en schrijf je in voor onze wekelijkse nieuwsbrief. Zo ben je altijd op de hoogte van de laatste ontwikkelingen op het gebied van de civiele cassatierechtspraak in Nederland.  Hoge Raad 1 maart 2024 ECLI:NL:HR:2024:298:https://deeplink.rechtspraak.nl/uitspraak?id=ECLI:NL:HR:2024:298

Welcome to the Instant Trivia podcast episode 1047, where we ask the best trivia on the Internet. Round 1. Category: Stay Away From Meat 1: AKA soybean curd, it can be frozen up to 3 months--but that will change its texture, making it slightly chewier. tofu. 2: This 5-letter term coined in 1944 is the beginning and end of "vegetarian". vegan. 3: Not "Yesterday" but in 2009, this musician and longtime vegetarian launched a "meat free Monday" campaign. Paul McCartney. 4: Kashi makes this type of crunchy grain-fruit-honey-nut breakfast cereal and bars of it, too. granola. 5: The Food Network says kosher salt is optional for a 1 lb. serving of this, Japanese for green soybeans. edamame. Round 2. Category: Dairy Products 1: A separator divides milk into light and heavy parts; this substance is light, so as they say, it rises to the top. cream. 2: Yogurt is made by curdling milk with purified cultures of these, like Streptococcus thermophilus. bacteria. 3: This process uses moderately high temperatures for a short time to kill microorganisms in milk. pasteurization. 4: Milk is tested for these, such as penicillin, which may have been used to treat cows that fell ill. antibiotics. 5: Greek-style this, like oikos, has become popular with its lush texture. yogurt. Round 3. Category: U.S. Mayors 1: In 1999 Oscar Goodman, once a lawyer for Tony "The Ant" Spilotro, was elected mayor of this Nevada city. Las Vegas. 2: In 1993 Thomas Menino became the 1st non-Irish American since 1929 elected mayor of this city. Boston. 3: It was a historic event when this man was sworn in in 1990. David Dinkins (first black mayor of NYC). 4: Ed Rendell was elected mayor of this city when Frank Rizzo died after the primary. Philadelphia. 5: In 1999 Mayor Wellington Webb of this state capital asked the NRA to cancel its convention there. Denver. Round 4. Category: Before And After: Singers And Writers 1: "The Heart Of Rock and Roll" lead singer who also wrote "Alice in Wonderland". Huey Lewis Carroll. 2: Folk trio that was "Blowin' In The Wind" with the writer of "Frankenstein". Peter, Paul and Mary Shelley. 3: "Super Freak" singer who also told "Tales of the South Pacific". Rick James Michener. 4: "Raindrops Keep Fallin' On My Head" singer who takes up a pen and creates "The Mayor of Casterbridge". B.J. Thomas Hardy. 5: "Hit The Road Jack" with the singer and pianist who also came up with the theory of evolution by natural selection. Ray Charles Darwin. Round 5. Category: Latin Lovers 1: It's Latin for "O Come, All Ye Faithful". "Adeste Fideles". 2: "Dictum sapient sat est" translates as "A word to" these people. The wise. 3: We've probably asked "Nil novi sub sole" before, as there's "Nothing new under" this. The sun. 4: It's what's no excuse in "Ignorantia legis neminem excusat". Ignorance of the law is no excuse. 5: Ancient Romans put great stock in "Ars moriendi", "The art" of doing this. Dying. Thanks for listening! Come back tomorrow for more exciting trivia!Special thanks to https://blog.feedspot.com/trivia_podcasts/ AI Voices used

Email: ⁠liamconnerly@gmail.com⁠ - ⁠latininlaymans@gmail.com ⁠ Website: ⁠https://latininlaymansarhetoricrevolution.wordpress.com/ --- Support this podcast: https://podcasters.spotify.com/pod/show/liam-connerly/support

.

Sir Paul Tucker, research fellow at The Harvard Kennedy School and former deputy governor of The Bank of England, joins Forward Guidance to discuss ideas from his latest book, “Global Discord: Values And Power In A Fractured World Order.”  Tucker tells Jack Farley that China's growing economic might and rejection of liberal values poses a challenge to the U.S.' role as global hegemon, and he details ways to reinvigorate international cooperation during the current period of geopolitical strife. Tucker shares his views on the recent turmoil in the banking system, weighing on Silicon Valley Bank, Credit Suisse, and the acute need for bank resolution that can maintain financial stability while winding down ailing banks. Tucker and Farley also discuss concepts such as the Triffin Dilemma, the offshore (“Eurodollar”) dollar system, and central banks' role as lenders of last resort.  __ “Global Discord” from Princeton Press: https://press.princeton.edu/books/hardcover/9780691229317/global-discord Global Discord on Amazon: https://www.amazon.com/Global-Discord-Values-Power-Fractured/dp/0691229317 __ About Paul Tucker: http://paultucker.me/resources/ About Tucker's work at The Harvard Kennedy School: https://www.hks.harvard.edu/centers/mrcbg/about/fellows/research-fellows#sir_paul_tucker More about today's guest: For over thirty years, Sir Paul Tucker was a central banker, and a member of the Bank of England's Monetary Policy Committee from 2002. He was Deputy Governor from 2009 to late 2013, including serving on the Financial Policy Committee (vice chair) and Prudential Regulatory Authority Board (vice chair). He was knighted by Britain in 2014 for his services to central banking. Internationally, he was a member of the steering committee of the G20 Financial Stability Board, and chaired its Committee on the Resolution of Cross-Border Banks to solve “too big to fail”. Tucker was a member of the board of directors of the Bank for International Settlements, and was chair of the Basel Committee for Payment and Settlement Systems from April 2012. After leaving central banking, Tucker was chair of the Systemic Risk Council from December 2015 to August 2021. He now writes at the intersection of political economy and political philosophy as research fellow at Harvard Kennedy School's Mossavar-Rahmani Center for Business and Government. In addition to “Global Discord,” Tucker is also the author of “ Unelected Power: The Quest for Legitimacy in Central Banking and the Regulatory State” (2018). __ Follow Jack Farley on Twitter https://twitter.com/JackFarley96 Follow Forward Guidance on Twitter https://twitter.com/ForwardGuidance Follow Blockworks on Twitter https://twitter.com/Blockworks_ __ Timestamps: (00:00) Intro (00:55) The Rise Of China Will Have Immense Consequences On A Global Scale (04:44) Shortcomings of Trade Policy and Enforcement (10:41) Downsides of U.S.' Trade Deficit (20:18) The Bretton Woods Regime (21:59) The Triffin Dilemma (26:32) The Eurodollar System (27:31) The Fed's Swap Lines In 2008 (28:49) Importance of Multi-Disciplinary Understanding For Policymakers (31:17) The Debt Ceiling (21:27) Thucydides' Trap (25:57) The Contest Between China and The U.S. Is "Everywhere" (39:26) Document 9 of The Chinese Communist Party (45:29) Inflation (49:37) Regional Bank Failure In The U.S. (55:43) The Takeover Of Credit Suisse By UBS (01:02:49) Defining A "Bailout" As A Use Of Taxpayer Money (01:07:09) Bagehot's Dictum (01:15:31) Credit Suisse Contingent Convertible ("CoCo") Bonds (01:17:55) Tying Geopolitical And Banking Together __ Disclaimer: Nothing discussed on Forward Guidance should be considered as investment advice. Please always do your own research & speak to a financial advisor before thinking about, thinking about putting your money into these crazy markets.

Adventures of a Pus Whisperer

Welcome to the Instant Trivia podcast episode 559, where we ask the best trivia on the Internet. Round 1. Category: Last But Not Least 1: He was the last U.S. president not sworn in by the Chief Justice of the U.S.. Lyndon Johnson. 2: Number of the last complete symphony by Beethoven. 9. 3: This band gave its last concert with Jerry Garcia at Chicago's Soldier Field in 1995. the Grateful Dead. 4: In 1550 he completed his last fresco, "The Crucifixion of St. Peter". Michelangelo. 5: The last NASA astronaut to fly in space alone was Ronald Evans as a part of this 1972 Apollo mission. Apollo 17. Round 2. Category: Queens 1: This queen was the mother of France's Louis XVII. Marie Antoinette. 2: Maria I, queen of this Iberian nation for 39 years, died in Brazil following Napoleon's invasion of her homeland. Portugal. 3: Britain's beloved Queen Mum, who died in 2002 at age 101, was this queen's mum. Queen Elizabeth II. 4: In 1654 Queen Christina of this Scandinavian nation shocked Europe by abdicating and moving to Rome. Sweden. 5: Not just a queen, but an archduchess, and and empress, she was the mother of another queen--Marie Antoinette. Maria Theresa. Round 3. Category: Continental Congressmen 1: The Conway Cabal, a New England congressional group, plotted to oust this man as commander-in-chief. George Washington. 2: Samuel Chase tried to corner the market on this mill product using congressional inside information. Flour. 3: 2 of the 4 great documents of the Continental Congress; Roger Sherman was the only man to sign all 4. (2 of) Declaration of Independence, Articles of Confederation, Articles of Association and The Constitution. 4: Francis Hopkinson claimed he designed this U.S. symbol; in 1781 Congress denied him sole credit. the U.S. flag. 5: Josiah Bartlett represented this colony; later he became governor and Dartmouth gave him an honorary M.D. degree. New Hampshire. Round 4. Category: Latin Lovers 1: It's Latin for "O Come, All Ye Faithful". "Adeste Fideles". 2: "Dictum sapient sat est" translates as "A word to" these people. The wise. 3: We've probably asked "Nil novi sub sole" before, as there's "Nothing new under" this. The sun. 4: It's what's no excuse in "Ignorantia legis neminem excusat". Ignorance of the law is no excuse. 5: Ancient Romans put great stock in "Ars moriendi", "The art" of doing this. Dying. Round 5. Category: Ranch Dressing 1: Somehow, shoppin' at Neiman Marcus for these trousers with a bib and shoulder straps don't feel right, but y'all can. overalls. 2: These "jingle jangle jingle as I go riding merrily along". spurs. 3: Parts of this metal item include the yoke, which wraps around the heel, and the rowel, a revolving wheel. a spur. 4: A bandito could wear this handkerchief as a scarf, a neckerchief or a mask. a bandana. 5: Ranch hands get protection from the brush by wearing these seatless leather items over their pants. chaps. Thanks for listening! Come back tomorrow for more exciting trivia! Special thanks to https://blog.feedspot.com/trivia_podcasts/

dictate; diction; dictation; dictionary; dictator; contra + dict; verdict; bene + diction; ad + dict; --- Support this podcast: https://anchor.fm/liam-connerly/support

“Liquidity” is a critical concept in markets that many may have heard, but few truly understand. Michael Howell, managing director at Cross Border Capital, is the global liquidity flows. He breaks down what liquidity is and he explains to Jack Farley how the tide of liquidity that has lifted asset prices over the past two years is reversing very quickly. Howell argues that, since 95% of central banks are tightening at the same time, the short-term risk/reward for stocks is poor, and he thinks a further 20% correction is ahead for the equity market. Howell explains the complex yield curve dynamics, and explains why the ongoing liquidity collapse might finally make long-term government bonds attractive once again.  Filmed on Tuesday, April 19, 2022. A note on the title: Howell's expectation of a 30% in stocks is from peak-to-trough, and since equities are down nearly 10% already, that would equate to a further fall of 20% from current levels (not 30% from current levels). _ Follow Cross Border Capital on Twitter @crossbordercap Follow Jack Farley on Twitter @JackFarley96 Follow Blockworks on Twitter @Blockworks _____ Bit.com is a full-suite cryptocurrency exchange launched by Matrixport, an integrated financial services firm headquartered in Singapore. Since August 2020, Bit.com has been online supporting the spot, perpetual, futures, fixed income and options products, with a particular highlight being pioneers to launch BCH options. Bit.com is the second-largest in the BTC and ETH options market. Call to action: For any further enquiry, please contact vip@bit.com. Sign up URL: https://bit.ly/3KlgLR3 App download URL: https://bit.ly/3xer6uI -- If you like this episode be sure to subscribe to our newsletter at https://blockworks.co/newsletter -- Timestamps -- (00:00) Introduction (00:45) What Is Liquidity?  (10:59) The Turbulence Zone (21:06) What Will Be The First To Break? (23:58) Why Are Stocks And Credit Still So Richly Priced? (26:35) But What About Inflation? (32:24) Bit.com Ad (43:32) Can China Save the Day? (47:05) Why Falling Liquidity Causes A Dollar Squeeze (50:33) How High Oil Prices Further Deteriorate Liquidity (53:04) History of Global Liquidity (56:28) Capital Wars and Bretton Woods III (1:08:25) Is The Yield Curve Signaling A Recession? (1:09:56) How Far Will The Fed Get With QT? (Bagehot's Dictum)

CardioNerds (Amit Goyal and Daniel Ambinder) join Dr. Loie Farina (Northwestern University CardioNerds Ambassador), Dr. Josh Cheema, and Dr. Graham Peigh from Northwestern University for drinks along the shores of Lake Michigan at North Avenue Beach. They discuss a case of a 52-year-old woman with limited cutaneous systemic sclerosis who presents with progressive symptoms of heart failure and is found to have a severe, non-ischemic cardiomyopathy. The etiology of her cardiomyopathy is not clear until her untimely death. She is ultimately diagnosed with cardiac AL amyloidosis with isolated vascular involvement a real occam's razor or hickam's dictum conundrum. We discuss the work-up and management of her condition including a detailed discussion of the differential diagnosis, the underlying features of systemic sclerosis with cardiac involvement as well as cardiac amyloidosis, the role of a shock team in managing cardiogenic shock, and how to identify those with advanced or stage D heart failure. Advanced heart failure expert Dr. Yasmin Raza (Northwestern University) provides the ECPR segment.  Episode introduction by CardioNerds Clinical Trialist Dr. Liane Arcinas. Claim free CME just for enjoying this episode!  Disclosures: NoneJump to: Pearls - Notes - References CardioNerds Case Reports PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Case Summary - Occam's Razor or Hickam's Dictum? This is a case of a 52-year-old woman with limited cutaneous systemic sclerosis who presented with progressive dyspnea on exertion and weight loss over the course of 1 year. Her initial work-up was notable for abnormal PFTs and finding of interstitial pneumonia on high-resolution CT, an ECG with frequent PVCs and normal voltage, a transthoracic echocardiogram with a mildly reduced ejection fraction of 40%, and a right/left heart catheterization with normal coronary arteries, filling pressures, and cardiac output. Scleroderma-related cardiac involvement is suspected. She is placed on GDMT, but her condition worsens over the next several months, and repeat echocardiogram shows severely reduced biventricular function, reduced LV global longitudinal strain (GLS) with apical preservation of strain, severely reduced mitral annular tissue Doppler velocities, and a normal left ventricular wall thickness. Scleroderma-related cardiac involvement remains highest on the differential, but because of some findings on the echo that are concerning for cardiac amyloidosis, an endomyocardial biopsy was obtained. It showed vascular amyloid deposition without interstitial involvement. The diagnosis of cardiac amyloid was discussed but deemed unlikely due to lack of interstitial involvement. However, a serologic work-up soon revealed a monoclonal serum lambda light chain and a follow-up bone marrow biopsy showed 20% plasma cells. She was discharged with very near-term follow-up in oncology clinic with a presumptive diagnosis of AL amyloidosis, but she unfortunately returned in shock and suffered a cardiac arrest. She initially survived and underwent emergent veno-arterial extracorporeal membrane oxygenation (VA ECMO) cannulation with subsequent left ventricular assist device placement (LVAD). However, she passed away due to post-operative hemorrhage. Autopsy was consistent with a final diagnosis of cardiac AL amyloidosis with isolated vascular involvement.  Case Media - Occam's Razor or Hickam's Dictum? EKG CXR TTE Pathology CMR Episode Teaching -Occam's Razor or Hickam's Dictum? Pearls Scleroderma causes repeated focal ischemia-reperfusion injuries which result in patchy myocardial fibrosis. Cardiac involvement in scleroderma is frequent but often not clinically evident; when symptomatic, it is associated with a poor prognosis.

 Main Fiction: "Dead Men Walking" by Jeremy Szal. This story was first published in Abyss and Apex in December, 2017.Jeremy Szal was born in 1995 and was raised by wild dingoes, which should explain a lot. He spent his childhood exploring beaches, bookstores, and the limits of people's patience. He's the author of over forty science-fiction short stories. His debut novel, STORMBLOOD, a dark space opera about a drug made from the DNA of extinct aliens that makes users permanently addicted to adrenaline and aggression, is out now from Gollancz as the first of a trilogy, with BLINDSPACE releasing sometime in 2021. He was the editor for the Hugo-winning StarShipSofa until 2020 and has a BA in Film Studies and Creative Writing from UNSW. He carves out a living in Sydney, Australia with his family. He loves watching weird movies, collecting boutique gins, exploring cities, cold weather, and dark humour. Find him at http://jeremyszal.com/ or @JeremySzal.Narrated by Fred Himebaugh.Fred Himebaugh lives a pulp fiction life and takes notes. His family lives with him, warily, in Ann Arbor, Michigan. Fred's fiction has appeared in Analog Science Fiction and Fact, Mysterion, and most recently at Distant Shore Publishing, but he is most proud that, after a long association with the StartShipSofa, working as a narrator, commentator, and Fan Number One, his story "Fingers" was selected for the Sofa in 2020. And then, Tony made him editor.You can also read novels by Fred, published under the name Frederick Gero Heimbach, namely The Devil's Dictum and Ronald Reagan's Brilliant Bullet. His third novel will be released by Liberty Island Media Group in a few months.Support this show http://supporter.acast.com/starshipsofa. See acast.com/privacy for privacy and opt-out information.

In this Chapter, The author Hemadpant describes the mission of saints on the earth. He Sanctity of Shirdi and describes it as "Holy Tirtha".Further, he narrates the Personality of Saibaba, Dictum of Gaulibua, How Lord vitthal appeared to Kakasaheb Dixit, Bhagwant Kshirsagar's story and the story of Das Ganu's bath in Prayag. The author closes the chapter by providing information about the three "wadas" or residential mensions in Shirdi.

In this week’s podcast, articles “The Cardiac Late Sodium Channel Current is a Molecular Target for the Sodium-Glucose Co-Transporter 2 Inhibitor Empagliflozin” by Light et al (www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.053350) and “Metabolic effects of empagliflozin in heart failure: A randomized, double-blind, and placebo-controlled trial (Empire HF Metabolic) by Jensen et al (www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.120.053463) are discussed. Dr. Carolyn Lam: Welcome to Circulation on the Run, your weekly podcast, summary and backstage pass to the journal and its editors. We're your co-hosts, I'm Dr. Carolyn Lam, associate editor from the National Heart Center and Duke National University of Singapore. Dr. Greg Hundley: And I'm Dr. Greg Hundley, associate editor, director of the Pauley Heart Center at VCU Health in Richmond, Virginia, Dr. Carolyn Lam: Greg, it's double feature day. And guess what? Both papers that we're going to talk about are regarding the SGLT2 inhibitors, and really look at the mechanism of action of these amazing compounds, from both a pre-clinical and clinic point of view. That's all I want to say, because we've got to tune in, a very interesting discussion coming right up. Dr. Carolyn Lam: But first I'd like to ask you a question. What do you think is the association between health-related quality of life and mortality in heart failure around the world? Dr. Greg Hundley: Well, Carolyn, I would think that, actually, they might be linked. Dr. Carolyn Lam: That's a really clever answer. Thanks Greg. Well, the authors are actually going to tell you with this next paper. It's from Dr. Salim Yusuf from Population Health Research Institute and McMaster University in Hamilton, Canada, and colleagues, who looked at the global congestive heart failure, or GCHF study, which is the largest study that has systematically examined health-related quality of life, measured by the Kansas City Cardiomyopathy Questionnaire, which is the largest study that has systematically examined health-related quality of life and its association with outcomes in heart failure, across eight major geographic regions, spanning five continents. Dr. Greg Hundley: Wow, Carolyn. So what did they find here? Dr. Carolyn Lam: Health-related quality of life, as measured by the Kansas City Cardiomyopathy Questionnaire, or KCCQ, really differs considerably between geographic regions, with markedly lower quality of life related to heart failure in Africa compared to elsewhere. Health-related quality of life was also a strong predictor of death and heart failure hospitalization in all regions, irrespective of symptoms class, and with both preserved and reduced ejection fraction. Dr. Carolyn Lam: Indeed, this paper really highlighted a great need to address disparities that impact health-related quality of life in patients with heart failure in different regions of the world. Dr. Greg Hundley: Fantastic, Carolyn. Well, I have two studies to discuss, Carolyn, and they're kind of similar, so we're going to do them back to back. The first study reports the results of the Sort Out X Trial, a large scale randomized multi-center, single-blind, two-arm, non-inferiority trial, with registry based follow-up designed to evaluate the Dual Therapy Sirolimus-Eluting, and CD34 positive antibody coated combo stent or DTS versus the Sirolimus-Eluting Orsiro Stent or SES. Dr. Greg Hundley: And the study comes to us from Dr. Lars Jakobson, from Arhus University Hospital. The primary endpoint target lesion failure, or TLF was a composite of cardiac death, myocardial infarction, or target lesion revascularization within 12 months, all analyzed using intention to treat. Dr. Carolyn Lam: All right, Greg. So the DTS compared to the SES, what did they find? Dr. Greg Hundley: Thanks, Carolyn. So the DTS did not confirm non-inferiority to the SES stent for target lesion failure at 12 months. The SES was superior to the DTS, mainly because the DTS was associated with an increased risk of target lesion revascularization. However, rates of death, cardiac death, and myocardial infarction at 12 months did not differ significantly between the two stent groups. Dr. Greg Hundley: Now Carolyn, in this same issue, we have another study evaluating endothelial function and implantation of intercoronary stents. And this second study comes to us from Professor Alexandra Lansky, from the Yale University School of Medicine and Yale Cardiovascular Research Group. And Carolyn, the study evaluated whether implantation of an intercoronary stent that facilitated endothelialization after the four to six weeks smooth muscle anti-proliferative effects post-stent implantation would be non-inferior to traditional drug-eluting stents. Dr. Carolyn Lam: Okay, another interesting study. And so, how did they do that? What did they find? Dr. Greg Hundley: Yeah, so Carolyn, a total of 1,629 patients were randomly assigned in a two to one fashion to the supreme DES stent, so 1,086 patients, or the DPDES stent, which was 543 patients. And there were no significant differences in rates of device success, clinically driven, target lesion revascularization, or stent thrombosis at 12 months. Dr. Greg Hundley: And the safety composite of cardiovascular death and target vessel revascularization or myocardial infarction was 3.5 versus 4.6% with the supreme DES stent compared to the DPDES stent. But target revascularization for this new stent was two and a half fold higher. Dr. Greg Hundley: So Carolyn looking at these two papers, what have we learned? So first, the Jakobsen, et al, tested whether the stainless steel COMBO Sirolimus-Eluting Stent coated luminally with CD34 positive antibody could theoretically capture endothelial progenitor cells and regrow endothelium. Dr. Greg Hundley: And the investigators observed that this stent had higher, not lower or equivalent, target lesion revascularization relative to the current generation Cobalt-Chrome Stent that only eluted sirolimus. Dr. Greg Hundley: In the second study, Lansky and associates examined an approach which was touted as enhancing endothelial recovery, where the early erosion of material and release of drug was thought to allow earlier endothelial recovery enhancing vascular response. Non-inferiority of the rapid release was demonstrated, but rather than hints of superiority, there were signs of inferiority. Hereto, target lesion revascularization was problematic and was two and a half fold higher. Dr. Greg Hundley: And so, Carolyn, there's a wonderful editorial from Professor Elazer Edelman from the Massachusetts Institute of Technology entitled, “Karnovsky's Dictum that Endothelium is Good Looking and Smart,” where Dr. Edelman emphasizes that while some endothelial cells may have been present after deployment of these devices, perhaps a fully constituted functioning endothelium may not have been achieved. Dr. Greg Hundley: And as we know, it is a fully functioning endothelium with nitric oxide release, buried platelet adhesion that is most protective. It is a really provocative read that reflects on previous thoughts from Morris Karnovsky, who suggests preservation of endothelial function is optimized by minimizing injury to it. And so, Carolyn, these combined articles really highlight the current state of new developments within interventional cardiology to thwart re-stenosis and highly recommend them to our readers. Dr. Carolyn Lam: Wow, thank you, Greg. That was amazing. But you know what, so's this next paper, because it really provides novel insights into that enigma of the role that the epicardium plays in the pathogenesis of arrhythmogenic cardiomyopathy. Dr. Carolyn Lam: Now, to delineate the contributions of the epicardium to the pathogenesis of arrhythmogenic cardiomyopathy, doctors Marian from University of Texas Health Science Center at Houston, Texas and colleagues performed a series of elegant mouse experiments using conditional deletion of the gene encoding desmoplakin in the epicardial cells of mice. Mutations in genes and coding desmosome proteins, including desmoplakin are known to be major causes of arrhythmogenic cardiomyopathy. Dr. Greg Hundley: Wow, Carolyn, very interesting. So what did they find here? Dr. Carolyn Lam: Epicardial derived cardiac fibroblasts and epithelial cells expressed paracrine factors, including TGF-β1 and fibroblasts growth factors, which mediated epithelial mesenchymal transition and contributed to the pathogenesis of myocardial fibrosis, apoptosis, arrhythmias, and cardiac dysfunction in a mouse model of arrhythmogenic cardiomyopathy. These findings really uncover contributions of the epicardial derived cells to the pathogenesis of arrhythmogenic cardiomyopathy. Dr. Carolyn Lam: Greg, there's a whole lot of other interesting stuff in today's series, as well. There's an exchange of letters among doctors Mehmood, doctors Moayedi and Dr. Birks regarding the article “Prospective Multicenter Study of Myocardial Recovery Using Left Ventricular Assist Device.” There's an ECG challenge by Dr. Ezekowitz on a silent arrhythmia. How would you treat this patient? Go quiz yourself. Dr. Carolyn Lam: There is an AHA Update by Dr. Churchwell on how federal policy changes can advance the AHAs mission to achieve health equity. And finally, a Perspective by Dr. Talbert on rheumatic fever and the American Heart Association, The Nearly 100 hundred-Year War. Well, that wraps it up for the summaries. Let's go to the double feature, shall we? Dr. Greg Hundley: You bet. Dr. Carolyn Lam: Wow, today's feature discussion is really all about SGLT2 inhibitors, and that question that we're still asking, how do they work? And today, we are discussing two papers, very interestingly, looking at it from different aspects, one from a preclinical lens, finding a very novel target for SGLT2 inhibitors, and the other from a clinical lens, and really looking at the metabolic effects of the SGLT2 inhibitors in a way you've not seen before. Dr. Carolyn Lam: I'm very pleased to have with us the authors of these very exciting papers. We have Dr. Jesper Jensen from Herlev and Gentofte University Hospital in Denmark. We have Dr. Peter Light from University of Alberta, in Canada, and we have our associate editors, Dr. Thomas Eschenhagen from University Medical Center, Hamburg, and Dr. Justin Ezekowitz from University Alberta. Dr. Carolyn Lam: So, welcome gentlemen, thank you so much for joining us today. I suggest, let's start from the mice before we go to the men, and Peter, if you don't mind by starting us in, please tell us about this novel target you found, why you looked at it, how you found it, what it means. Dr. Peter Light: Hi, Carolyn, yeah, happy to discuss that. So, we all know that through numerous clinical trials, there's a very unexpected and exciting cardioprotective effect against heart failure with the SGLT2 inhibitors. And we decided to investigate some of the molecular mechanisms, which may underlie that protection. And in looking at the literature previously, and from my own lab's work, we're very interested in control of electrical excitability and ionic homeostasis in cells. Dr. Peter Light: So we investigated a known target or a known iron channel, which is involved in the etiology of heart failure as well as cardiac arrhythmias. And that would be the cardiac sodium channel. So, we investigated the effects specifically on a component of the cardiac sodium channel called the late sodium current, which is only induced in disease states, and they could be that during heart failure or ischemia, or can actually be in congenital conditions such as Long QT Syndrome Three, which involves certain mutations in this sodium channel. Dr. Peter Light: So we basically investigate the effects of empagliflozin, dapagliflozin and canagliflozin, in several different models of a sodium channel dysfunction, including mice with heart failure. And really what we've found is that this class of drug, and this is a class effect, it's not specific to just one of these SGLT2 inhibitors, what we found, they are very good inhibitors of this late current of the sodium channel. And in fact, they don't even affect the peak current at all. Dr. Peter Light: And when we did this and we analyzed the data, we found the IC 50s were in the low micromolar or even sub micromolar range for these drugs, which is exciting. And we extended those studies into cardiac myocytes and looked at calcium handling in those cardiac myocytes and saw that we get a very nice reduction in abnormal calcium handling in cardiac myocytes. Dr. Peter Light: We also used in silico molecular docking of these drugs to the cryo-EM structure of the NaV1.5, which is the cardiac sodium channel and identified that these drugs bind to a known region of that channel, which also binds the local anesthetics or anti-arrhythmic drug, Lidocaine, as well as the anti-anginal drug, Ranolazine. Dr. Peter Light: And finally, we showed that these drugs also reduce inflammation through the NLRP3 inflammasome in an isolated beating heart model. So collectively, we provide evidence that the late component of the sodium channel is a really important, or maybe a really important target for the molecular actions of this drug, and may underlie those observations received from the clinical trials relating both to heart failure, as well as sudden cardiac death. Dr. Carolyn Lam: Thomas, could you put this in context for us? Dr. Thomas Eschenhagen: Thanks, Carolyn. I mean, we immediately liked the story because as you said, and Peter as well, these drugs have amazing effects and every clinical paper and indeed some new ones, but it's really unclear how they do that. And what is, besides the established target, the SGL2 in the kidney, what could be the reason for all of this or some of this?   Dr. Thomas Eschenhagen: And then, of course, other examples proposed, like the sodium hydrogen exchanger, but this story didn't go so far. So we saw now this data from Peter showing that, and this is, of course, for a pharmacologist, just like me, very important, it's very potent binding. It's not a binding which happens in a millimolar or high micromolar, but as Peter said in low micromolar range. So that makes it a very realistic effect, for example, much more potent than ranolazine. Dr. Thomas Eschenhagen: And, of course, now the question is, to which extent could this, now I would say, establish the effect on the late sodium current, explain some of the findings which came out of the clinical studies, and actually, a question I would have to Peter, now that I think most of you know, the late sodium current is a reason for the increased sodium for LQT3 syndrome, very rare. Dr. Thomas Eschenhagen: But, of course it would be tempting to say, okay, maybe that would be a very good drug, particularly for people with LQT3. Did you think about that, Peter? Is it something on your list, mexiletine has been tried. Dr. Peter Light: Yeah, so I think that it's a certainly intriguing possibility. In fact, in our study, we did test out several different Long QT3 mutations and saw a reduction in the late component as also sodium channel. It's tempting to speculate that, indeed, these could actually be a rather effective anti-arrhythmic drug in patients with these LQT3 mutations or specific ones. I would love to be able to test that in at least some of the genetic mouse models of Long QT3 and to see whether this concept holds water or not. Dr. Carolyn Lam: Wow, this is incredible. SGLT2 inhibitors from anti-diabetic to now anti failure, and now anti-arrhythmic drugs? That's just amazing. Thank you, Peter. We should move on to this next paper, and this one all the way on the other spectrum, a clinical paper called Empire Heart Failure, Empire Heart Failure Metabolic, actually. Jesper, could you tell us about your trial and what you found? Dr. Jesper Jensen: Sure, thanks for the invitation to take part in the podcast, first of all. I'll tell you a little bit, we designed this study to try to get behind mechanisms, so the clinical benefits of the SGLT2 inhibitors in order to try to make a clinical outcome trial. But as you know, the DAPA-HF and the EMPEROR-Reduced were competed very fast, demonstrating the clinical benefits in HFrEF patients. Dr. Jesper Jensen: So, the data of our study provides some detailed mechanistic insights to these findings. And from the literature, we know that SGLT2 inhibitors improve glucose metabolism in patients with diabetes, and these changes might not be surprising in the diabetes population, but moreover, alterations in glucose metabolism may not be the main mechanism for the early occurring clinical benefits. Dr. Jesper Jensen: However, we know that many of our heart failure patients without diabetes are insulin resistant as a metabolic feature of the heart failure, and the insulin resistance is associated with an increased risk of developing future diabetes, which in turn reduces the long-term survival and quality of life. So, the targeting insulin resistance in HFrEF patients is, therefore, of clinical relevance to our patients. Dr. Jesper Jensen: So, the population of the Empire HF Metabolic consisted of patients with chronic HFrEF, with or without type two diabetes, who are on a stable guideline directed heart failure therapy, and have also indicated on anti-diabetic therapy. And we randomized patients to receive empagliflozin 10 milligrams once daily, or matching placebo as an-add on for 12 weeks. Dr. Jesper Jensen: And this was a modest sized randomized control trial, including 120 patients. A very large proportion of patients received guideline directed heart failure therapy, and they generally consisted of the best one third of atypical HFrEF population, and only 10% had concomitant history of type two diabetes. Dr. Jesper Jensen: We then, at baseline and after 12 weeks, we formed an oral glucose tolerance test to assess the hepatic and a peripheral insulin sensitivity and performed a whole body DXA scan to investigate alterations in body composition. We know that patients lose weight when they get an SGLT2 inhibitor with and without diabetes, but we don't know what it consists of in a HFrEF population. Dr. Carolyn Lam: Tell us what you found after 12 weeks. Dr. Jesper Jensen: Yeah, so a large proportion, actually half of the patients without a history of diabetes, had a new onset diabetes, or impact glucose tolerance at baseline. So even though few have no diabetes, this population were at very high risk of developing future diabetes. And the main finding was that empagliflozin improved insulin sensitivity. So the hepatic insulin sensitivity was improved by 13% and the peripheral insulin resistance was improved by 20% compared to placebo. Dr. Jesper Jensen: And moreover, both fasting and postprandial glucose were significantly reduced. And regarding the body composition, patients in a mean lost at 1.2 kilos, or 2.6 pounds, which mainly consisted of a loss in lean mass and no significant changes were observed in fatness, and this is from the DXA scan. Dr. Carolyn Lam: Hmm. Justin, could you shed some light on what the editors thought about this, and there's lots of questions still, huh? Dr. Justin Ezekowitz: Yeah, absolutely, Carolyn, and thanks Jesper for sharing this paper with Circulation. Thanks for summarizing it so well. I think the questions that come up and the reason why we liked it so much was we're all trying to understand mechanism of how these medications work so profoundly for our patients. Dr. Justin Ezekowitz: Now, in this predominantly non-diabetic population, the fact that the liver and the peripheral insulin sensitivity improves, how does that bear out for the fact that there is no fat loss in the early stages, yet that's all been linked to later improved exercise capacity and increased fat loss later on in life. Dr. Justin Ezekowitz: So, do you think those two are going to be linked if you went to say from 12 weeks beyond the 52 or two years down the road? Dr. Jesper Jensen: Yes, that is what we've seen from diabetes populations, at least. So you could imagine that the same would be the case also in the HFrEF primarily non-diabetic population, but again, we don't know. But early loss is the mass loss. Dr. Justin Ezekowitz: So Jesper, when you think about the peripheral insulin sensitivity improvement, is that largely indicating mostly muscle based insulin sensitivity improvement, and that would indicate that the muscles, perhaps, are functioning better in the short term with just a simple change in therapy. Dr. Jesper Jensen: Yeah, that could be a way to put it. I would agree upon that. Dr. Justin Ezekowitz: So thanks, Jesper, I think that may indicate the quality of life improvement that we may be seeing in the functional status there, Carolyn. Dr. Carolyn Lam: Yeah, but as you said, Justin, there just seems so many other questions. To Jesper, I want to know, what further might you want to do to find out what's happening with this? The loss of lean mass surprised me, frankly. I thought it would have been fat mass. So, what are you doing to look at that? And then to Peter, I want to go the other direction. What are you planning next that might bring this closer to humans and a clinical study? So maybe I'll ask Jesper to go first. Dr. Jesper Jensen: So, I definitely agree with you, Carolyn. We would also have to put our money on the fat from the beginning, before the study. So with respect to the weight loss, then a loss in lean mass is not preferable if it represents muscle. So however, the weight loss works to mediate the observed change in insulin resistance. And additionally, a significant loss in muscle would result in reduced insulin sensitivity. And we observed the opposite. Therefore, the observed loss in lean mass may be speculated to represent water and pointing towards the early diuretic effect SGLT2 inhibitors. So, the DXA scan is good at looking at body composition, but it has difficulties in separating lean mass from whether it's muscle or water, but combined with the findings on the insulin resistance, we speculate that the lean mass loss is more. Dr. Carolyn Lam: Thank you. And Peter, could you very quickly tell us what are next steps, in your view? Dr. Peter Light: Yeah, obviously we were studying mouse model of heart failure. We'd like to make a more of a translational step in the next experiments we do by studying human tissues. So getting access to ventricular tissue from ex-planted hearts, human hearts, too, and then measure electrical activity as well as some calcium imaging. Dr. Peter Light: Looking at some of these Long QT3 animal models would be another thing that we're going to do. And also start looking at to see whether we can get access to any electrophysiological data from electronic medical records to start looking for DCGs and measuring QT interval, for example, would be another nice step to that. Dr. Peter Light: And then, more of a drug development side of things, we are actively synthesizing new derivatives of these drugs and seeing whether we can enhance the cardio-protective effects on the late sodium current, but actually remove the ability to inhibit SGLT2. So we would no longer have a glucose-lowering drug, but we'd have a cardioprotective drug. So, it's all very exciting work going on right now. Dr. Carolyn Lam: You've been listening to Circulation on the Run. From Greg and I, don't forget to tune in again next week. Dr. Greg Hundley: This program is copyright of the American Heart Association, 2021. The opinions expressed by speakers in this podcast are their own and not necessarily those of the editors or of the American Heart Association. For more, visit ahajournals.org.  

In this episode, I share some of my thoughts about Descartes's cogito ergo sum argument. I've heard from just about all sides, that Descartes's dictum is a blatantly fallacious argument and as such, it is a massive failure. But after reading Descartes for myself, I'm not so sure. Now I think the cogito is actually a successful transcendental argument. Check out this episode for my reasons why. If you like this podcast, then support it on Patreon for $1, $3, or $5 a month. Any amount helps, and for $5 you get a Parker's Pensées sticker and instant access to all the episode as I record them instead of waiting for their release date. Check it out here: Patreon: https://www.patreon.com/parkers_pensees If you want to give a one-time gift, you can give at my Paypal: https://paypal.me/ParkersPensees?locale.x=en_US Check out my merchandise at my Teespring store: https://teespring.com/stores/parkers-penses-merch Check out my blog posts: https://parkersettecase.com/ Check out my YouTube page: https://www.youtube.com/channel/UCYbTRurpFP5q4TpDD_P2JDA Check me out on Twitter: https://twitter.com/trendsettercase Instagram: https://www.instagram.com/parkers_pensees/ Time Is Running by MusicLFiles Link: https://filmmusic.io/song/6203-time-is-running License: http://creativecommons.org/licenses/by/4.0/ --- Support this podcast: https://anchor.fm/parker-settecase/support

Occam's razor is a theory advanced by medieval times philosopher known as William Ockham, which states that the simpler explanation of any two is usually the right one. It gives preference for simplicity when looking for solutions or causes of problems.The razor part relates to shaving things down to the simplest solution. Entrepreneurs are always solving problems, but sometimes we make things more complex than they need to be. All things being equal, the simplest solution tends to be the best one.In the fitness space, Occam's Razor Theory can be used when dealing with your team and also with your clients. For your team, the processes and steps need to be the easiest and most efficient for achieving the desired outcome.Whether you are an entrepreneur or a coach, you need to understand this theory. Tune in to this episode and hear Rick explain how it relates to fitness and how you can apply it for greater results.Key TakeawaysWhat is Occam's Razor theory? (01:08)How we overcomplicate it in the fitness space (03:52)How to apply the Occam’s Razor with your team (06:29)At the end of the day, it's a lot easier if you go with the simplest solution (09:44)How the Occam's Razor could help clients move better (17:58)Occam's Razor vs. Hickman's Dictum (21:39)Additional Resources:www.AlloyPersonalTraining.comLearn About The Alloy Franchise Opportunity---------You can find the podcast on Apple, Google, Spotify, Stitcher, or wherever you listen to podcasts.If you haven’t already, please rate and review the podcast on Apple Podcasts!

Neste episódio eu vou iniciar a minha leitura do Dicionário de Filosofia Oxford na Letra A. Apresentando a falácia em Latim: a dicto secundum quid ad dictum simpliciter. --- Send in a voice message: https://anchor.fm/stoiczoya/message

“Secrets and Sinkholes” Keirnan reveals many truths about himself and Razor and Grena Brightflame grow closer.  The heroes go underground to find another missing Easog and get more than they bargained for. Also the Architects are plagued by shiny rocks.   Music Theme song by Andy Calabrese, www.andycalabrese.com “A Fond Farewell” by David Celeste www.epidemicsound.com  “Dictum” by Ethan Sloane www.epidemicsound.com   “Now We Fight” by Bonnie Grace  www.epidemicsound.com   Website https://aoepodcast.blubrry.net/ Like us in facebook https://www.facebook.com/archentpod Email us at entropypod@gmail.com

Partys in der Szene gibt es in den unterschiedlichsten Varianten. Große, kleine, nur fürs spielen oder mehr fürs tanzen, ... Einer der größten Veranstalter in Deutschland ist "Sub Rosa Dictum" Jedes Jahr stellt das Team rund um Christian, viele verschiedene außergewöhnliche Partys auf die Beine. Zahlreiche Gäste machen sich hübsch und kommen aus ganz Deutschland um die ausgelassene Atmosphäre zu erleben. Wir sprechen mit Christian über die Faszination dieser Veranstaltungen, seine Ideenfindung und über die vielen schönen Momente, die man in der Szene erlebt. Links zu den Veranstaltungen: SubRosaDictum https://subrosadictum.de AVANTGARDISTA https://avantgardista.net Soziale Medien: Instagram: https://instagram.com/notvanillapodcast Facebook: https://www.facebook.com/notvanillapodcast Twitter: https://twitter.com/NotVanillaPod Tumblr: https://www.tumblr.com/blog/notvanillapodcast E-Mail: NotVanillaPodcast@gmx.de

Satura Lanx podcast is moving from Podomatic to Anchor. If you used to listen to my podcast on Podomatic (or if someday you don't see new any new episod in your usual podcasts feed), please go to https://anchor.fm/satura-lanx and subscribe to my podcast again on the platform you prefer. You can also listen to Litterae Latinae Simplices on my YouTube channel (just search for Satura Lanx on YouTube). For any problems, write to saturalanx@saturalanx.eu. I don't want to lose contact with you because of this moving!

Latin Quotes In Latin - Latin Quotes read out loud! I scrap out Latin Quotes about Death, Latin Quotes about War and Latin Quotes about Life from around the Web and Books and read them out loud. First in latin, then in english. Twice. I also read out loud Audiobooks in Latin. If you Love Latin just as much as we do, and if you are grateful for this Podcast, and want us to keep us producing it, make a donation or buy now all 2000 Latin Quotes In Latin WITHOUT ANY ADS for little bucks bound together in Audiobook Format here: payhip.com/lqil

"Sermon on the Mount" series | Chris McGarvey

This Evening Dr. Broderick will talk about:Dictum-all one needs to present with epilepsy is a brainThe DataSerotonin/Tryptophan-Epilepsy Patientepilepsy and Parkinson's disease-neurodegenerate alike Epilepsy with Tumor: Leukodystrophy_White Matter DiseasesWhite Matter Signalling with the BRODERICK PROBE nanobiosensorCleveland Clinic-epilepsy patient and classical music on the violin.The Brain, Limbic Brain, The Temporal Lobe, Temporal Lobe SeizuresTemporal Lobe EpilepsyMesial and Neocortical Temporal Lobe EpilepsySubtype by electrophysiology-Subtype by neurochemistry and the BRODERICK PROBEReligion and EpilepsyUnderstanding the Epilepsy BrainUnderstanding the Epilepsy PatientPsychosisCase StudiesLobectomy- Mr. Malaison-the HM CASE.Kathleen Kennedy CaseDr. Oliver SachsPsychosis and HallucinationsSt. Paul Conversion

This Week, Dr. Broderick will talk about:Dictum_ all one needs to present with epilepsy is a brainAura, ictal, interictal and postictal epileptic orgasmsDostoyevskyAbsence, focal and tonic clonic seizuresTraumaCleveland Clinic-epilepsy patient and classical music on the violin.The Brain, Limbic Brain, The Temporal Lobe, Temporal Lobe SeizuresTemporal Lobe EpilepsyMesial and Neocortical Temporal Lobe EpilepsySubtype by electrophysiology-Subtype by neurochemistry and the BRODERICK PROBEReligion and EpilepsyUnderstanding the Epilepsy BrainUnderstanding the Epilepsy PatientPsychosisCase StudiesLobectomy- Mr. Malaison-the HM CASE.Kathleen Kennedy CaseDr. Oliver SachsPsychosis and HallucinationsSt. Paul ConversionSerotonin and Tryptophan - epilepsy and Parkinson's disease

Henry III (1 October 1207 – 16 November 1272), also known as Henry of Winchester, was King of England, Lord of Ireland, and Duke of Aquitaine from 1216 until his death.[1] The son of King John and Isabella of Angoulême, Henry assumed the throne when he was only nine in the middle of the First Barons' War. Cardinal Guala declared the war against the rebel barons to be a religious crusade and Henry's forces, led by William Marshal, defeated the rebels at the battles of Lincoln and Sandwich in 1217. Henry promised to abide by the Great Charter of 1225, which limited royal power and protected the rights of the major barons. His early rule was dominated first by Hubert de Burgh and then Peter des Roches, who re-established royal authority after the war. In 1230, the King attempted to reconquer the provinces of France that had once belonged to his father, but the invasion was a debacle. A revolt led by William Marshal's son, Richard, broke out in 1232, ending in a peace settlement negotiated by the Church. Following the revolt, Henry ruled England personally, rather than governing through senior ministers. He travelled less than previous monarchs, investing heavily in a handful of his favourite palaces and castles. He married Eleanor of Provence, with whom he had five children. Henry was known for his piety, holding lavish religious ceremonies and giving generously to charities; the King was particularly devoted to the figure of Edward the Confessor, whom he adopted as his patron saint. He extracted huge sums of money from the Jews in England, ultimately crippling their ability to do business, and as attitudes towards the Jews hardened, he introduced the Statute of Jewry, attempting to segregate the community. In a fresh attempt to reclaim his family's lands in France, he invaded Poitou in 1242, leading to the disastrous Battle of Taillebourg. After this, Henry relied on diplomacy, cultivating an alliance with Frederick II, Holy Roman Emperor. Henry supported his brother Richard in his bid to become King of the Romans in 1256, but was unable to place his own son Edmund on the throne of Sicily, despite investing large amounts of money. He planned to go on crusade to the Levant, but was prevented from doing so by rebellions in Gascony. By 1258, Henry's rule was increasingly unpopular, the result of the failure of his expensive foreign policies and the notoriety of his Poitevin half-brothers, the Lusignans, as well as the role of his local officials in collecting taxes and debts. A coalition of his barons, initially probably backed by Eleanor, seized power in a coup d'état and expelled the Poitevins from England, reforming the royal government through a process called the Provisions of Oxford. Henry and the baronial government enacted a peace with France in 1259, under which Henry gave up his rights to his other lands in France in return for King Louis IX recognising him as the rightful ruler of Gascony. The baronial regime collapsed but Henry was unable to reform a stable government and instability across England continued. In 1263, one of the more radical barons, Simon de Montfort, seized power, resulting in the Second Barons' War. Henry persuaded Louis to support his cause and mobilised an army. The Battle of Lewes occurred in 1264, where Henry was defeated and taken prisoner. Henry's eldest son, Edward, escaped from captivity to defeat de Montfort at the Battle of Evesham the following year and freed his father. Henry initially enacted a harsh revenge on the remaining rebels, but was persuaded by the Church to mollify his policies through the Dictum of Kenilworth. Reconstruction was slow and Henry had to acquiesce to various measures, including further suppression of the Jews, to maintain baronial and popular support. Henry died in 1272, leaving Edward as his successor. He was buried in Westminster Abbey, which he had rebuilt in the second half of his reign, and was moved to his current tomb in 1290. Some miracles were declared --- Support this podcast: https://anchor.fm/allthingsplantagenet/support

Henry III (1 October 1207 – 16 November 1272), also known as Henry of Winchester, was King of England, Lord of Ireland, and Duke of Aquitaine from 1216 until his death.[1] The son of King John and Isabella of Angoulême, Henry assumed the throne when he was only nine in the middle of the First Barons' War. Cardinal Guala declared the war against the rebel barons to be a religious crusade and Henry's forces, led by William Marshal, defeated the rebels at the battles of Lincoln and Sandwich in 1217. Henry promised to abide by the Great Charter of 1225, which limited royal power and protected the rights of the major barons. His early rule was dominated first by Hubert de Burgh and then Peter des Roches, who re-established royal authority after the war. In 1230, the King attempted to reconquer the provinces of France that had once belonged to his father, but the invasion was a debacle. A revolt led by William Marshal's son, Richard, broke out in 1232, ending in a peace settlement negotiated by the Church. Following the revolt, Henry ruled England personally, rather than governing through senior ministers. He travelled less than previous monarchs, investing heavily in a handful of his favourite palaces and castles. He married Eleanor of Provence, with whom he had five children. Henry was known for his piety, holding lavish religious ceremonies and giving generously to charities; the King was particularly devoted to the figure of Edward the Confessor, whom he adopted as his patron saint. He extracted huge sums of money from the Jews in England, ultimately crippling their ability to do business, and as attitudes towards the Jews hardened, he introduced the Statute of Jewry, attempting to segregate the community. In a fresh attempt to reclaim his family's lands in France, he invaded Poitou in 1242, leading to the disastrous Battle of Taillebourg. After this, Henry relied on diplomacy, cultivating an alliance with Frederick II, Holy Roman Emperor. Henry supported his brother Richard in his bid to become King of the Romans in 1256, but was unable to place his own son Edmund on the throne of Sicily, despite investing large amounts of money. He planned to go on crusade to the Levant, but was prevented from doing so by rebellions in Gascony. By 1258, Henry's rule was increasingly unpopular, the result of the failure of his expensive foreign policies and the notoriety of his Poitevin half-brothers, the Lusignans, as well as the role of his local officials in collecting taxes and debts. A coalition of his barons, initially probably backed by Eleanor, seized power in a coup d'état and expelled the Poitevins from England, reforming the royal government through a process called the Provisions of Oxford. Henry and the baronial government enacted a peace with France in 1259, under which Henry gave up his rights to his other lands in France in return for King Louis IX recognising him as the rightful ruler of Gascony. The baronial regime collapsed but Henry was unable to reform a stable government and instability across England continued. In 1263, one of the more radical barons, Simon de Montfort, seized power, resulting in the Second Barons' War. Henry persuaded Louis to support his cause and mobilised an army. The Battle of Lewes occurred in 1264, where Henry was defeated and taken prisoner. Henry's eldest son, Edward, escaped from captivity to defeat de Montfort at the Battle of Evesham the following year and freed his father. Henry initially enacted a harsh revenge on the remaining rebels, but was persuaded by the Church to mollify his policies through the Dictum of Kenilworth. Reconstruction was slow and Henry had to acquiesce to various measures, including further suppression of the Jews, to maintain baronial and popular support. Henry died in 1272, leaving Edward as his successor. He was buried in Westminster Abbey, which he had rebuilt in the second half of his reign, and was moved to his current tomb in 1290. Some miracles were declared --- Support this podcast: https://anchor.fm/allthingsplantagenet/support

In this episode, I discuss what you can learn from Gene Kranz after the Apollo 1 disaster --- Send in a voice message: https://anchor.fm/tboc/message Support this podcast: https://anchor.fm/tboc/support

Mark Kritzman graduated with a business degree in a time of intense crisis and change in financial markets, and this experience shaped the arc of his career. He has dedicated his professional life to the study of asset allocation and portfolio optimization and his papers on these and other topics have earned over a dozen top awards in finance, including nine Bernstein/Fabozzi/Levy Awards. This conversation between ReSolve’s CIO Adam Butler and Mark is loosely guided by core themes from Mark’s newest book, “A Practitioner’s Guide to Asset Allocation”. Mark describes why he embraces Samuelson’s Dictum and how this has motivated his focus on asset allocation as the most fertile ground for active returns. Relatively small traders can drive mis-priced securities back to equilibrium but asset classes can – and do – stray far from equilibrium because traders lack the capital necessary to correct mis-pricings on their own. This is exacerbated by other barriers to arbitrage like institutional tracking error constraints and benchmark-oriented incentives. Given Mark’s views it’s not surprising that his team at Windham Capital focuses mostly on Tactical Asset Allocation. He expresses the view that the policy portfolio concept is profoundly misguided since markets have highly unstable distributions. Dynamic markets imply that optimal portfolios should change over time in response to changes in expected return, risk and correlation dynamics. Mark makes the case that portfolio optimization gets a bad rap but that most of the protests are disingenuous. Sure, out-of-the box optimization is error-maximizing on portfolio weights but that’s irrelevant for a few simple reasons, most prominently because no one with any sense would use an optimizer out-of-the-box, but also because while small changes in portfolio estimates might lead to large changes in weights, the expected mean and variance of the portfolio would hardly change at all. We address the 1/N arguments and Mark makes clear why they’re bunk. We cover a lot more ground but toward the end Mark divulges that he’s publishing a new paper with mind-blowing implications. I won’t give away the plot here… Mark has forgotten more about finance than most investors will learn in their career. Put down what you’re doing and listen to this right now.

Estamos en una constante lucha de poderes. Hay personas que se aprovechan de ello para su propio beneficio, utilizan el poder sabiamente. ¿Será cierto que el poder nos corrompe? En este episodio discutimos acerca de poder y sobre los experimentos que los psicólogos han realizado.

Dictum meum pactum is a phrase I learned in high school whilst writing essays for my application to Oxford University and it is the first thing that comes to mind when I think of reputation. It is something that I have oft found not possessed by people, and nor understood, both figuratively and literally. It means ‘my word is my bond’ and it has been the motto of the London Stock Exchange since 1801. Early on in my career, as a wet behind the ear, but enthusiastic banker, I rapidly realized idealistic principles were not widely held beliefs. This is something I have never adapted to and it has cost me. A VP once said to me “What is with this loyalty to the firm when the firm is never going to be loyal to you?” I don’t recollect responding, but it is something that has stuck with me and I never came to terms with. You can read the blog here: https://www.alexanderjarvis.com/2014/...

The first population study in history was born out of a dramatic debate involving leeches, “medical vampires,” professional rivalries, murder accusations, and, of course, bloodletting, all in the backdrop of the French Revolution. The second of a multipart series on the development of population medicine, this episode contextualizes Pierre Louis’ “numerical method,” his famous trial on bloodletting, and the birth of a new way for doctors to “know”. Plus a brand new #AdamAnswers about Occam’s razor and Hickam’s Dictum. All this and more on Episode 38 of Bedside Rounds, a tiny podcast about fascinating stories in clinical medicine! To claim CME and MOC credit, please go to www.acponline.org/BedsideRounds.   Best M and Neuhauser D, “Pierre Charles Alexandre Louis: Master of the spirit of mathematical clinical science,” Qual Saf Health Care 2005;14:462–464. Duffin J, “Laennec and Broussias: The ‘Sympathetic’ Duel,” from La Berge A and Hannaway C, Paris Medicine: Perspective Past and Present. (1977) The French Revolution: A Revolution in Medicine, Too, Hospital Practice, 12:11, 127-138 Hillard A, et al. “Occam’s Razor versus Saint’s Triad, N Engl J Med 2004;350:599-603. Lo Re V 3rd, Bellini LM, William of Occam and Occam's razor. Ann Intern Med. 2002 Apr 16;136(8):634-5. Kirk GW and Pemberton N. Leech, 2013 Kirk GW and Pemberton N, Re-imagining Bleeders: The Medical Leech in the Nineteenth Century Bloodletting Encounter. Med Hist. 2011 Jul; 55(3): 355–360. La Berge A and Hannaway C, Paris Medicine: Perspective Past and Present. Louis PCA. Researches On The Effects Of Bloodletting In Some Inflammatory Diseases. Boston: Hilliard, Gray, 1836. Morabia A. PCA Louis and the birth of clinical epidemiology. J Clin Epidemiol 1996;49: 1327-33 Morabia A, Pierre-Charles-Alexandre Louis and the evaluation of bloodletting. J R Soc Med. 2006 Mar; 99(3): 158–160. Niehyl PH. The English bloodletting revolution, or modem medicine before 1950. Bull Hist Med 1977; 51, pp. 464-483. Papavramidou N and Christopolou-Aletra H, Medicinal use of leeches in the texts of ancient Greek, Roman and early Byzantine writers. Intern Med J. 2009 Sep;39(9):624-7. “Suckers for Success,” Nature volume 484, page 416 (26 April 2012). “Walter Chatton,” Stanford Encyclopedia of Philosophy, retrieved from: https://plato.stanford.edu/entries/walter-chatton/ Wardrop D, “Ockham’s Razor: sharpen or re-sheathe?” J R Soc Med. 2008 Feb; 101(2): 50–51.

Dr. Eliana Bonifacino is back alongside our new guest, Dr. Drew Klein. Listen along as Occam’s razor and Hickam’s Dictum fight it out for the final diagnosis/diagnoses(?!) Reinforce your learning with the following questions. As you listen along, fill out the learning objectives to actively engage and participate with us! Loading…

This is the second talk of the Cambridge Society for Law and Governance in the New Economy. Aurelio Gurrea Martínez and Nydia Remolina León talk on the topic 'Initial Coin Offerings: Regulatory Challenges and Risks'. Aurelio Gurrea Martínez is a Corporate Governance and Teaching Fellow in Capital Markets and Financial Regulation at Harvard Law School, Founder and Executive Director of the Ibero-American Institute for Law and Finance, and Lecturer in Business Law and Director of International Programs at the Centro de Estudios Garrigues. He studied law and business (LLB, BA, PhD) in Spain, where he is also a qualified auditor. He received a Master of Science in Law and Finance from the University of Oxford and a Master of the Science of Law from Stanford University. Aurelio has been an advisor to the Spanish Ministry of Justice and a national expert for the assessment of the Spanish insolvency and secured transaction regime conducted by the International Monetary Fund. Aurelio has been a visiting researcher at various institutions, including Harvard Law School, Columbia Law School, Yale Law School, and the Max Planck Institute, and he is an instructor for the Global Certificate Program for Securities Regulators organised by Harvard Law School and the International Organization of Securities Commissions. He is founding partner at Dictum, a business law firm with offices in Spain and Hong Kong. In 2016, he was named Rising Star of Corporate Governance by the Millstein Center for Global Markets and Corporate Ownership at Columbia Law School. Nydia Remolina León is a Lecturer in Financial Regulation at the University of Los Andes and Senior Advisor for Innovation, Regulation and Digital Transformation at Bancolombia, one of the largest financial groups in Latin America. She holds a Master of the Science of Law (focusing on capital markets, corporate finance, and financial innovation) from Stanford University, and a Law degree and a Master’s in Capital Markets from Javeriana University. She has acted as a senior consultant to the OECD, and she practiced at Sullivan & Cromwell (New York Office) specialising in financial regulation, M&A, and Fintech. She is a Research Associate at the Ibero-American Institute for Law and Finance and a Member of the International Advisory Board of the Foundation for Financial Innovation and the Digital Economy. Nydia has delivered lectures at numerous institutions in the United States, Asia, Europe, and Latin America, and she has been invited to speak about Fintech and Regtech at various international organisations, including the International Monetary Fund and the International Organization of Securities Commissions. Jenifer Varzaly and Pablo M. Baquero are Co-convenors of Law and Governance in the New Economy.

This is the second talk of the Cambridge Society for Law and Governance in the New Economy. Aurelio Gurrea Martínez and Nydia Remolina León talk on the topic 'Initial Coin Offerings: Regulatory Challenges and Risks'. Aurelio Gurrea Martínez is a Corporate Governance and Teaching Fellow in Capital Markets and Financial Regulation at Harvard Law School, Founder and Executive Director of the Ibero-American Institute for Law and Finance, and Lecturer in Business Law and Director of International Programs at the Centro de Estudios Garrigues. He studied law and business (LLB, BA, PhD) in Spain, where he is also a qualified auditor. He received a Master of Science in Law and Finance from the University of Oxford and a Master of the Science of Law from Stanford University. Aurelio has been an advisor to the Spanish Ministry of Justice and a national expert for the assessment of the Spanish insolvency and secured transaction regime conducted by the International Monetary Fund. Aurelio has been a visiting researcher at various institutions, including Harvard Law School, Columbia Law School, Yale Law School, and the Max Planck Institute, and he is an instructor for the Global Certificate Program for Securities Regulators organised by Harvard Law School and the International Organization of Securities Commissions. He is founding partner at Dictum, a business law firm with offices in Spain and Hong Kong. In 2016, he was named Rising Star of Corporate Governance by the Millstein Center for Global Markets and Corporate Ownership at Columbia Law School. Nydia Remolina León is a Lecturer in Financial Regulation at the University of Los Andes and Senior Advisor for Innovation, Regulation and Digital Transformation at Bancolombia, one of the largest financial groups in Latin America. She holds a Master of the Science of Law (focusing on capital markets, corporate finance, and financial innovation) from Stanford University, and a Law degree and a Master’s in Capital Markets from Javeriana University. She has acted as a senior consultant to the OECD, and she practiced at Sullivan & Cromwell (New York Office) specialising in financial regulation, M&A, and Fintech. She is a Research Associate at the Ibero-American Institute for Law and Finance and a Member of the International Advisory Board of the Foundation for Financial Innovation and the Digital Economy. Nydia has delivered lectures at numerous institutions in the United States, Asia, Europe, and Latin America, and she has been invited to speak about Fintech and Regtech at various international organisations, including the International Monetary Fund and the International Organization of Securities Commissions. Jenifer Varzaly and Pablo M. Baquero are Co-convenors of Law and Governance in the New Economy.

This is the second talk of the Cambridge Society for Law and Governance in the New Economy. Aurelio Gurrea Martínez and Nydia Remolina León talk on the topic 'Initial Coin Offerings: Regulatory Challenges and Risks'. Aurelio Gurrea Martínez is a Corporate Governance and Teaching Fellow in Capital Markets and Financial Regulation at Harvard Law School, Founder and Executive Director of the Ibero-American Institute for Law and Finance, and Lecturer in Business Law and Director of International Programs at the Centro de Estudios Garrigues. He studied law and business (LLB, BA, PhD) in Spain, where he is also a qualified auditor. He received a Master of Science in Law and Finance from the University of Oxford and a Master of the Science of Law from Stanford University. Aurelio has been an advisor to the Spanish Ministry of Justice and a national expert for the assessment of the Spanish insolvency and secured transaction regime conducted by the International Monetary Fund. Aurelio has been a visiting researcher at various institutions, including Harvard Law School, Columbia Law School, Yale Law School, and the Max Planck Institute, and he is an instructor for the Global Certificate Program for Securities Regulators organised by Harvard Law School and the International Organization of Securities Commissions. He is founding partner at Dictum, a business law firm with offices in Spain and Hong Kong. In 2016, he was named Rising Star of Corporate Governance by the Millstein Center for Global Markets and Corporate Ownership at Columbia Law School. Nydia Remolina León is a Lecturer in Financial Regulation at the University of Los Andes and Senior Advisor for Innovation, Regulation and Digital Transformation at Bancolombia, one of the largest financial groups in Latin America. She holds a Master of the Science of Law (focusing on capital markets, corporate finance, and financial innovation) from Stanford University, and a Law degree and a Master’s in Capital Markets from Javeriana University. She has acted as a senior consultant to the OECD, and she practiced at Sullivan & Cromwell (New York Office) specialising in financial regulation, M&A, and Fintech. She is a Research Associate at the Ibero-American Institute for Law and Finance and a Member of the International Advisory Board of the Foundation for Financial Innovation and the Digital Economy. Nydia has delivered lectures at numerous institutions in the United States, Asia, Europe, and Latin America, and she has been invited to speak about Fintech and Regtech at various international organisations, including the International Monetary Fund and the International Organization of Securities Commissions. Jenifer Varzaly and Pablo M. Baquero are Co-convenors of Law and Governance in the New Economy.

This is the second talk of the Cambridge Society for Law and Governance in the New Economy. Aurelio Gurrea Martínez and Nydia Remolina León talk on the topic 'Initial Coin Offerings: Regulatory Challenges and Risks'. Aurelio Gurrea Martínez is a Corporate Governance and Teaching Fellow in Capital Markets and Financial Regulation at Harvard Law School, Founder and Executive Director of the Ibero-American Institute for Law and Finance, and Lecturer in Business Law and Director of International Programs at the Centro de Estudios Garrigues. He studied law and business (LLB, BA, PhD) in Spain, where he is also a qualified auditor. He received a Master of Science in Law and Finance from the University of Oxford and a Master of the Science of Law from Stanford University. Aurelio has been an advisor to the Spanish Ministry of Justice and a national expert for the assessment of the Spanish insolvency and secured transaction regime conducted by the International Monetary Fund. Aurelio has been a visiting researcher at various institutions, including Harvard Law School, Columbia Law School, Yale Law School, and the Max Planck Institute, and he is an instructor for the Global Certificate Program for Securities Regulators organised by Harvard Law School and the International Organization of Securities Commissions. He is founding partner at Dictum, a business law firm with offices in Spain and Hong Kong. In 2016, he was named Rising Star of Corporate Governance by the Millstein Center for Global Markets and Corporate Ownership at Columbia Law School. Nydia Remolina León is a Lecturer in Financial Regulation at the University of Los Andes and Senior Advisor for Innovation, Regulation and Digital Transformation at Bancolombia, one of the largest financial groups in Latin America. She holds a Master of the Science of Law (focusing on capital markets, corporate finance, and financial innovation) from Stanford University, and a Law degree and a Master’s in Capital Markets from Javeriana University. She has acted as a senior consultant to the OECD, and she practiced at Sullivan & Cromwell (New York Office) specialising in financial regulation, M&A, and Fintech. She is a Research Associate at the Ibero-American Institute for Law and Finance and a Member of the International Advisory Board of the Foundation for Financial Innovation and the Digital Economy. Nydia has delivered lectures at numerous institutions in the United States, Asia, Europe, and Latin America, and she has been invited to speak about Fintech and Regtech at various international organisations, including the International Monetary Fund and the International Organization of Securities Commissions. Jenifer Varzaly and Pablo M. Baquero are Co-convenors of Law and Governance in the New Economy.

Stump the Rabbi - Rabbi Yossi Paltiel “When ten Jews gather, the Shechinah rests with them ” Are women included in this dictum? To ask a question and for more answers visit: http://stumptherabbi.org/ This project was made possible by The Chanin Fund Reliable Fast Cash, LLC http://reliablefastcash.com/ Rabbi Yossi Paltiel http://insidechassidus.org STR 279

Some of us may be trained to assume there is always a single unifying etiology of our patients symptoms, but that isn't always necessarily the case.  This week I sit down with Dr. Aaron Schneider to talk about a Cool Sono, Bro where Occam's razor didn't really work out.   Check it out and let me know what you think! We still have a few spots left for CaboFEST 2018! Offer code "5MINSONO10" gets you 10% off! If the beach isn't "castle-y" enough for you, come hang out with us in Versailles, Kentucky at Castlefest 2018!   Check out my other podcasts, ultrasoundpodcast.com and ultrasoundgel.org.  Subscribe and get emails everytime a new episode comes out!

Mark Kritzman is a Senior Lecturer in Finance at the MIT Sloan School of Management, founding Partner and Chief Executive Officer of Windham Capital Management and serves as a senior partner of State Street Associates. Mark has written six books, his latest titled “A Practitioners Guide to Asset Allocation”. Mark began his career on Wall Street in 1974 and was immediately drawn toward systematic trading. At a time when there were not many quantitative traders, he was affectionately titled a “token quant” within his company. Over the years Mark has been an advisor to many funds. While working with various companies it became clear fund managers were mixing how they invest with how they would choose asset classes. He decided to break down the most basic and logical ways of organizing the investment process. What are some components of an asset class: stable composition, be investable, internally homogeneous, externally heterogeneous, raise the utility of a portfolio, and you should be able to access it in a cost effective way. From there, depending on a persons risk, different combinations of asset classes would make up a portfolio. Being in the game as long as Mark has, he has been able to witness the enduring and turbulent nature of markets. He saw one silver lining come out of the 2008 financial crisis – it provided a context where investors could go back to the basics of trading, and in particular, recalibrate how they manage risk. Mark finishes the podcast talking fixed weight portfolios, Peter Bernstein on scaling portfolio risk, dynamic asset allocation and explaining Samuelson’s Dictum. In this episode of Trend Following Radio: Definition of an asset class Actively managed portfolios Passively managed portfolios Time diversification Portfolio diversification The fallacy of large numbers Leverage Value at risk Risk management Fear and greed Risk and reward Exposure to risk

Pastor Adrian explains the fight against marriage and family.

Coach Durkee introduces his own Dictum Debate: Don’t Bring Logos to a Pathos Fight. Hear a break down of one of the most influential speeches by Barack Obama. Plus, we answer some concerns from last week’s Dictum. Show notes: Radiolab Debatable: http://www.radiolab.org/story/debatable/ Big think article: http://bigthink.com/experts-corner/decisions-are-emotional-not-logical-the-neuroscience-behind-decision-making.amp Barack Obama’s 2004 speech: http://v.youku.com/v_show/id_XMjQ4ODMzMzczMg==.html?from=y1.7-1.2&spm=a2hzp.8244740.0.0  

Coaches Josh and Durkee unveil their first Dictum of Debate and share wisdom from two American debate coaching legends.  Plus, a special message for all of their competitors.

This week on "A Way with Words": People in ancient times could be just as bawdy and colorful as we are today. To prove it, we found some graffiti written on the walls in the city of Pompeii, and found plenty of sex, arrogance and good old fashioned bathroom talk etched in stone. Plus, British rhyming slang makes its way to our televisions through police shows on PBS. And a dictionary for rock climbers gives us a fantastic word that anyone can use to describe a rough day. Also, spitting game, hornswoggling, two kinds of sloppy joes, peppy sad songs, and endearing names for grandma. FULL DETAILS When Mount Vesuvius erupted in 79 A.D., parts of the ancient city of Pompeii remained intact, including the graffiti written on its walls. Much of what was written, not unlike today's bathroom etchings, is naughty and boastful, with people like Celadus the Thracian claiming to be the one who "makes the girls moan." A Tallahassee, Florida, mother who texted her daughter in a hurry accidentally asked about the "baby woes," meaning "baby wipes," and came to the conclusion that we need a new phrase: read between the autocorrect. If you watch British police procedurals, you'll likely come across the term to grass someone, meaning "to inform on someone" or "to rat someone out." It's a bit of British rhyming slang that originated with the 19th-century phrase to shop on someone. That gave us the noun shopper, which became grasshopper, and then got shortened to grass. A Japanese version of the idiom the grass is always greener translates to "the neighbor's flowers are red." The word hornswoggle, meaning "to embarrass" or "to swindle," is of unclear origin, but definitely seems of a piece with U.S. frontier slang from the 1830s and 1840s. Our Quiz Guy John Chaneski has a game called Dictum wherein he gives us a word, like contrary or emasculate, and we have to guess the closest bold-faced word that comes after it in the dictionary. Tougher than you might think! A listener whose first language is Farsi wonders if the name of the grandma in the classic film An Affair to Remember, gave us the endearment nanu, for grandmother. In Mediterranean countries, words like nanu, nana, nene and nona are all common terms for "granny." Here's a truism that often appeared scribbled in ancient wall graffiti: I wonder, oh wall, that you have not yet collapsed. So many writers' cliches do you bear. The term spitting game, meaning "to flirt," comes from African-American slang going back to at least the 1960's, when game referred to someone's hustle. It's well covered in Randy Kearse's Street Talk: Da Official Guide to Hip-Hop and Urban Slanguage. Martha recalls that as an English major, she nearly memorized William Zinsser's On Writing Well. He died this month at age 92, and she'll remember this quote, among others: "Ultimately, the product any writer has to sell is not the subject being written about, but who he or she is...I often find myself reading with interest about a topic I never thought would interest me — some scientific quest, perhaps. What holds me is the enthusiasm of the writer for his field." A listener from northern New Jersey says that in his part of the state, a sloppy joe was not the mashed-up ground beef sandwich many of us also know as a loose meat sandwich, spoonburger, or tavern. For him, a sloppy joe was a deli meat sandwich that consisted of things like pastrami, turkey, coleslaw, Russian dressing and rye bread. Here's a lovely bit of ancient graffiti found on the wall of an inn: "We have wet the bed. I admit, we were wrong, my host. If you ask why, there was no chamberpot." Pro wrestling, a fake sport with a very real following, has a trove of lingo all its own that can be found in the newsletter and website PW Torch. One saying, red means green, refers to the fact that a wrestler who winds up bloody will get a prettier payout for his or her performance. And kayfabe is a wrestler's character persona, which he or she often keeps up for any public appearance, even outside the ring. A fan of Bruce Springsteen's song "Dancing in the Dark" called to say that she's noticed the lyrics are awfully sad for such a peppy tune, and wonders if there's a word for this phenomenon. Lyrical dissonance would do the job, but there's also the term agathokakological, a Greek-influenced word meaning "both good and evil." One listener followed up our discussion of classic literary passages turned into limerick form by writing one of his own, a baseball-themed poem that begins, "There once was a batter named Casey." Vermont is one place—but not the only one—where non-natives are referred to as flatlanders, and people who've been around generations proudly call themselves woodchucks. It's written about on Shawn Kerivan's blog, Innkeeping Insights in Stowe. The Climbing Dictionary by Matt Samet includes a fantastic term that can be used by non-climbers as well: high gravity day, a day when all routes, even easy ones, seem impossible due to a seeming increase in gravity. The expression to a T comes from a shortening of tittle, a word meaning a little of something. The word tittle even shows up in the bible. There's also an idiom to the teeth, as in dressed to the teeth, or fully armored-up. This episode is hosted by Grant Barrett and Martha Barnette. -- A Way with Words is funded by its listeners: http://waywordradio.org/donate Get your language question answered on the air! Call or write with your questions at any time: Email: words@waywordradio.org Phone: United States and Canada toll-free (877) WAY-WORD/(877) 929-9673 London +44 20 7193 2113 Mexico City +52 55 8421 9771 Donate: http://waywordradio.org/donate Site: http://waywordradio.org/ Podcast: http://waywordradio.org/podcast/ Forums: http://waywordradio.org/discussion/ Newsletter: http://waywordradio.org/newsletter/ Twitter: http://twitter.com/wayword/ Skype: skype://waywordradio Copyright 2016, Wayword LLC.

EM Cases Best Case Ever - Chris Nickson on Hickam's Dictum. Usually we use the heuristic of Occam's razor to help us arrive at one diagnosis that makes sense of all the data points that a particular patient presents to us. However sometimes it's not so straight forward and we need to think about multiple diagnoses that explain a patient's condition - Hickam's Dictum. Dr. Chris Nickson, the brains behind the Life in the Fast Lane blog tells his Best Case Ever from the SMACC Conference in Dublin, in which a patient thrombolysed for massive pulmonary embolism suffers a cardiac arrest, and the thought process he went through to discover the surprising complicating diagnoses that ensue... The post Best Case Ever 46 – Chris Nickson on Hickam's Dictum appeared first on Emergency Medicine Cases.

EM Cases Best Case Ever - Chris Nickson on Hickam's Dictum. Usually we use the heuristic of Occam's razor to help us arrive at one diagnosis that makes sense of all the data points that a particular patient presents to us. However sometimes it's not so straight forward and we need to think about multiple diagnoses that explain a patient's condition - Hickam's Dictum. Dr. Chris Nickson, the brains behind the Life in the Fast Lane blog tells his Best Case Ever from the SMACC Conference in Dublin, in which a patient thrombolysed for massive pulmonary embolism suffers a cardiac arrest, and the thought process he went through to discover the surprising complicating diagnoses that ensue... The post Best Case Ever 46 – Chris Nickson on Hickam’s Dictum appeared first on Emergency Medicine Cases.

This week on "A Way with Words": People in ancient times could be just as bawdy and colorful as we are today. To prove it, we found some graffiti written on the walls in the city of Pompeii, and found plenty of sex, arrogance and good old fashioned bathroom talk etched in stone. Plus, British rhyming slang makes its way to our televisions through police shows on PBS. And a dictionary for rock climbers gives us a fantastic word that anyone can use to describe a rough day. Also, spitting game, hornswoggling, two kinds of sloppy joes, peppy sad songs, and endearing names for grandma.FULL DETAILSWhen Mount Vesuvius erupted in 79 A.D., parts of the ancient city of Pompeii remained intact, including the graffiti written on its walls. Much of what was written, not unlike today's bathroom etchings, is naughty and boastful, with people like Celadus the Thracian claiming to be the one who "makes the girls moan."A Tallahassee, Florida, mother who texted her daughter in a hurry accidentally asked about the "baby woes," meaning "baby wipes," and came to the conclusion that we need a new phrase: read between the autocorrect.If you watch British police procedurals, you'll likely come across the term to grass someone, meaning "to inform on someone" or "to rat someone out." It's a bit of British rhyming slang that originated with the 19th-century phrase to shop on someone. That gave us the noun shopper, which became grasshopper, and then got shortened to grass. A Japanese version of the idiom the grass is always greener translates to "the neighbor's flowers are red."The word hornswoggle, meaning "to embarrass" or "to swindle," is of unclear origin, but definitely seems of a piece with U.S. frontier slang from the 1830s and 1840s. Our Quiz Guy John Chaneski has a game called Dictum wherein he gives us a word, like contrary or emasculate, and we have to guess the closest bold-faced word that comes after it in the dictionary. Tougher than you might think!A listener whose first language is Farsi wonders if the name of the grandma in the classic film An Affair to Remember, gave us the endearment nanu, for grandmother. In Mediterranean countries, words like nanu, nana, nene and nona are all common terms for "granny." Here's a truism that often appeared scribbled in ancient wall graffiti: I wonder, oh wall, that you have not yet collapsed. So many writers' cliches do you bear.The term spitting game, meaning "to flirt," comes from African-American slang going back to at least the 1960's, when game referred to someone's hustle. It's well covered in Randy Kearse's Street Talk: Da Official Guide to Hip-Hop and Urban Slanguage. Martha recalls that as an English major, she nearly memorized William Zinsser's On Writing Well. He died this month at age 92, and she'll remember this quote, among others: "Ultimately, the product any writer has to sell is not the subject being written about, but who he or she is...I often find myself reading with interest about a topic I never thought would interest me — some scientific quest, perhaps. What holds me is the enthusiasm of the writer for his field."A listener from northern New Jersey says that in his part of the state, a sloppy joe was not the mashed-up ground beef sandwich many of us also know as a loose meat sandwich, spoonburger, or tavern. For him, a sloppy joe was a deli meat sandwich that consisted of things like pastrami, turkey, coleslaw, Russian dressing and rye bread.Here's a lovely bit of ancient graffiti found on the wall of an inn: "We have wet the bed. I admit, we were wrong, my host. If you ask why, there was no chamberpot."Pro wrestling, a fake sport with a very real following, has a trove of lingo all its own that can be found in the newsletter and website PW Torch. One saying, red means green, refers to the fact that a wrestler who winds up bloody will get a prettier payout for his or her performance. And kayfabe is a wrestler's character persona, which he or she often keeps up for any public appearance, even outside the ring.A fan of Bruce Springsteen's song "Dancing in the Dark" called to say that she's noticed the lyrics are awfully sad for such a peppy tune, and wonders if there's a word for this phenomenon. Lyrical dissonance would do the job, but there's also the term agathokakological, a Greek-influenced word meaning "both good and evil."One listener followed up our discussion of classic literary passages turned into limerick form by writing one of his own, a baseball-themed poem that begins, "There once was a batter named Casey."Vermont is one place—but not the only one—where non-natives are referred to as flatlanders, and people who've been around generations proudly call themselves woodchucks. It's written about on Shawn Kerivan's blog, Innkeeping Insights in Stowe.The Climbing Dictionary by Matt Samet includes a fantastic term that can be used by non-climbers as well: high gravity day, a day when all routes, even easy ones, seem impossible due to a seeming increase in gravity.The expression to a T comes from a shortening of tittle, a word meaning a little of something. The word tittle even shows up in the bible. There's also an idiom to the teeth, as in dressed to the teeth, or fully armored-up.This episode is hosted by Grant Barrett and Martha Barnette.--A Way with Words is funded by its listeners: http://waywordradio.org/donateGet your language question answered on the air! Call or write with your questions at any time:Email: words@waywordradio.orgPhone: United States and Canada toll-free (877) WAY-WORD/(877) 929-9673London +44 20 7193 2113Mexico City +52 55 8421 9771Donate: http://waywordradio.org/donateSite: http://waywordradio.org/Podcast: http://waywordradio.org/podcast/Forums: http://waywordradio.org/discussion/Newsletter: http://waywordradio.org/newsletter/Twitter: http://twitter.com/wayword/Skype: skype://waywordradio Copyright 2015, Wayword LLC.

Esther Lofgren: Olympic gold medalist rowing: Story of success created by following the dictum of "Harder Better Faster Stronger"

Esther Lofgren: Olympic gold medalist rowing: Story of success created by following the dictum of "Harder Better Faster Stronger"

“FCU: Fact Checker’s Unit” follows the adventures of two overzealous fact checkers – Russell (Karinen) and Dylan (Sacca) – who work at the popular Dictum magazine and stop at nothing to check the most absurd celebrity facts. No star is too big and no fact too obscure or arcane to run down for accuracy’s sake. The series will feature globally recognizable guest stars as themselves and check facts such as those concerning Luke Perry: (Is Luke’s house really haunted?), Alex Trebek (Does Alex shave against the grain?), Dave Navarro (Does Dave insist that the tears of a virgin, beetles and finger sandwiches be provided backstage at any venue he plays?) and Karolina Kurkova (Does Karolina use SPF 125 at the beach?). At NYU's Tisch School of the Arts, students pointed and laughed at Peter Karinen and Brian Sacca. Thus, in 2003, it made sense to start cashing in on this phenomenon and take to the stage at the Upright Citizens Brigade Theatres in NYC and LA. Their most acclaimed oeuvre, "Pete and Brian's One Man Show," simultaneously touched and offended capacity audiences on both coasts, and was an official selection of the 2007 HBO US Comedy Arts Festival in Aspen. Since then, Pete and Brian have written two almost-funny-enough pilots for 20th Century Fox, amassed an almost-impressive online following by making a ton of web videos -- including two seasons of the series "Single Dads" for Fox International Channels -- and have written for numerous award shows, including the MTV Movie Awards. Their first foray into fact checking came in 2008, when their short film "FCU: Fact Checkers Unit" (co-created with Dan Beers and starring Bill Murray) was an official selection of the Sundance Film Festival. They are currently developing two almost-original screenplays with Ben Stiller's Red Hour Films and "Zombieland" director Ruben Fleischer.

--{ Manipulative Masters, Sons of Perdition, Blame the Conquered For World's Condition: "Those Who Vote Hope to Relieve the Strain, Newly-Elected Now Promise Years of Pain, And 'Baby Boomers' Given Cultural Dysfunction Are Blamed for Chaos and Financial Destruction, 'So it's All Your Fault, You Lived too Well', Say the Financial Gatekeepers, Engineers of Hell, Doublespeak, Reverse Blame is Psychopaths' Dictum, Where Perpetrators Turn to Blame the Victim Whose Conditioned Confusion, Firewall-Mentality, Will Inhibit Him Reaching Factual Reality, Geopolitical, Psychological, Familial Disasters, Courtesy Financial, Educational, Media Masters" © Alan Watt }-- The Internet Drug, Information Overload - Media Spins - Getting Stuck in Diversions - Peasants Kept in Ignorance - British Empire, Build-up and Unification of India - Technocrats with Real Power - Depopulation Agenda - Margaret Sanger - Maurice Strong (Rockefeller's Protege), UN Environment Conferences, Earth Charter, Agenda 21, Earth Inc. - Destruction of the Family Unit - The Pervert Kinsey - Devaluation of Human Life - Opinion Creation, Mass Mind Manipulation through Weaponized Media and Marketing - Left Wing / Right Wing, Body hides behind the Shield - US Expands "Secret" War Globally - Politically Useful Tool of the US. British Unofficial yet Promoted One-Child Policy, Single Parent Families - Planned World Society - Public Blamed for Everything, Must Now Suffer (and PAY) - Unpayable Debts. (See http://www.cuttingthroughthematrix.com for article links.) *Title/Poem and Dialogue Copyrighted Alan Watt - June 7, 2010 (Exempting Music, Literary Quotes, and Callers' Comments)

The Airspeed Safety Stand-Down, featuring the Kranz Dictum from January of 1967.

--{ Sexualized Society, Sterile Variety: "Promoted Variety, Sterile Copulation, Yet Elite Still Hype Overpopulation, Big Daddy UN Says with a Frown, 'We've Got to Bring Their Numbers Down,' Using the Dictum of Thomas Malthus, Under Guise of Right to Choose, Pretended Champion of All Women, While Male Spermatozoa Hardly Swimmin', Blaring Their Agenda for All to Hear, Yet Never Asking for Volunteer, How to Make Their Plan Accomplish? Check Sperm Under Scope in Petri Dish" © Alan Watt }-- Philosophers, Formula, History - Religion for Control, Feudal System, Serfs - Middle Ages, British-French Wars, WWII Posters of Japanese, Dehumanized Enemies. Jacques Ellul, Promoted Wants of Public - Real Purpose of United Nations, Depopulation Agenda, Kissinger - Cairo Conference, Sustainable Development (Population Reduction), NGOs. Infertility in West, Bisphenol-A - Huxleys, Scientific Dictatorship - Bush, Terrorism Acts, Totalitarianism - Britain, ID Card, Post Offices, Pharmacies - Merchant Bankers, Pharma Industry. Giving Away Personal Data - Bernays, Marketing, McDonald's Camps - Media Complaints. Anthropology, Study of Culture - Allowed Choices - Devaluation of Life. Emergency Camps, Weather Warfare, Coastal Regions - Water and Food Takeover, Total Dependence on System, Agenda 21. "We're All in it Together" Slogan - Voting for President - B'nai Brith Charter (Freemasonic) - Air Force, Weather Reports - Zbigniew Brzezinski, Public Parroting Media Topics. Shriners, Area Planning, Town Boards, Councils, Eastern Star. (Articles: ["Cairo Conference reaches consensus on plan to stabilize world growth by 2015 - International Conference on Population and Development" UN Chronicle, Dec. 1994 (at findarticles.com).] ["Post office ID card role discussed" (virginmedia.com) - May 6, 2009.] ["The many-headed serpent that threatens freedom of the press" (independent.co.uk) - May 4, 2009.]) *Title/Poem and Dialogue Copyrighted Alan Watt - May 6, 2009 (Exempting Music, Literary Quotes, and Callers' Comments)

--{ Supervising Stampedes in Age of Crisis Creation: "Welcome to the Century of Crisis Creation, Demolishing Old Ways, Bringing Frustration, Silent Consent, All Rights Receding, Recall of Rights Like Some Dream Fleeting, Stampeding Herds Guided to Trap, Using Darwin's Dictum, 'Learn to Adapt,' From New Norm to New Norm, We Upgrade, 'Til We're Interdependent, Alone, Afraid, Almost There, Point We Arrive, Dependent on State for Means to Survive" © Alan Watt }-- Public Herd, Crisis Management - Pre World War II America, Individualism - CFR - Brzezinski, Personal Computers, Internet, Data Collection, NSA, Monitoring. Military-Industrial Complex- Obsolete Computer Systems and Programs, Planned Frustration - "Cloud" Computing, Google, Online Storage - Mouse Traps Mexican "Pandemic", SARS Outbreak, Quarantine, Thermal Imaging Scans, Hype - "Deadly Allies" book, Canada, Bacterial and Viral Warfare. Spanish Flu - Creation of Weaponized Killer Flu Virus - Crop Fungus, Mad Cow Disease - Panic and Crisis, Adaptation, Constant Upgrading - Laboratories, Antidotes. Profit from Terror and Fear - War on Civilians, Worldwide Police State - Marxism, Authoritarianism, Military Think Tank Reports. Britain as Prototype, Total Surveillance, Databases, Government and Police Spying. Sudden Experts Advising Us - Behavioural Conditioning. (Articles: [See cuttingthroughthematrix.com for links.] ["Google plans to make PCs history" by David Smith (guardian.co.uk) - Jan. 25, 2009.] ["Scientists isolate genes that made 1918 flu lethal" Yoshihiro Kawaoka, University of Wisconsin-Madison (eurekalert.org) - Dec. 29, 2008.] ["Venture capital firm set to reap rewards on swine flu" by Alexander Haislip (reuters.com) - April 27, 2009.] ["Give us back our private lives" by Alasdair Palmer and David Barrett (telegraph.co.uk) - April 25, 2009.] ["Police can snoop on every email and eavesdrop on Internet phone calls under new plan" (dailymail.co.uk) - April 25, 2009.]) *Title/Poem and Dialogue Copyrighted Alan Watt - April 27, 2009 (Exempting Music, Literary Quotes, and Callers' Comments)

Parallel Session IV-A, Sunday Afternoon, 3 August 2008, Alternative Energy Sources and Their Impact; Engineering and Appropriate Technology