Podcasts about Coxsackie

Join Meg Faure and regular guest Julia this week as they catch up on life with 10-month-old Aurelia and nearly four-year-old Santi. Julia shares the exhaustion of navigating Aurelia's current sleep disruptions, likely caused by a combination of illness, teething, and developmental leaps towards walking. Meg offers practical tips and reassurance for getting through these common 10-month hurdles.Decoding 10-Month Sleep ChallengesAurelia, usually an easy baby, has been struggling with night wakings and sometimes fighting bedtime. Meg breaks down the potential causes:Basic Needs: Persistent colds might lead to glue ear (congestion causing pressure). She recommends a quick pharmacy check and discusses saline solutions or decongestants if needed. Coxsackie virus (hand, foot & mouth) is also currently rife and could cause irritability. Iron levels are crucial post-6 months; Meg suggests dietary sources (spinach, red meat) or supplements like Floradix, and shares a recipe from the Weaning Sense book.Sleep Schedules: At 10 months, babies consolidate to two naps. Meg advises capping total day sleep (around 2-2.5 hours) and potentially shortening the afternoon nap if the morning one is long, to prevent night waking from undertiredness. Dropping the third nap is essential if that hasn't happened yet.Sensory & Development: Babies working on new motor skills (like pulling up/walking) often have disrupted sleep. Providing ample movement (vestibular) and deep pressure (proprioceptive) input during the day, like swinging, can help. Milestones & Sibling ComparisonsJulia notes how differently Aurelia and Santi approach milestones. Santi was a speedy crawler, while Aurelia is more focused on pulling up to stand. Meg shares fascinating insights on milestone consolidation: sometimes, babies who achieve gross motor milestones like walking earlier (even 9 months!) might be less coordinated later than those who take longer, as slower consolidation builds a stronger foundation. It's a reminder not to rush development.The Primary School Pressure CookerThe conversation takes a significant turn as Julia discusses Santi turning four and the looming decisions about schooling. Both Meg and Julia express concerns about the pressure to enter expensive private school systems early, driven by commercial interests and parental fears. They discuss the option of public schools for primary years, allowing for diverse experiences and less academic pressure.Slowing Down & Work-Life BalanceJulia shares her recent positive experience of pulling back slightly on work commitments. By getting extra help, she's found more capacity as a parent and reduced stress.Why Listen?Packed with practical sleep tips for the common 10-month regression, insights into developmental milestones, a thought-provoking discussion on early education choices, and relatable honesty about work-life balance, this episode offers valuable sense and support for parents navigating these stages.

Virgil and Mark chat with Greg Mills, co-owner with his partner Sydney of The Hi-Way Drive-In in Coxsackie, NY, nestled at the foot of the Catskills, about being new to the Drive-In ownership world, first year lessons learned, mixing retro and first-run titles, weather woes, bringing fresh ideas to a classic business model, and more.Recorded 10/30/24Visit the Hi-Way online at:https://hiwaydrivein.com/https://www.facebook.com/HiWayDriveInTheatre/https://www.instagram.com/hiwaydriveinnyhttps://www.tiktok.com/@hiwaydriveinCheck out our map of all of the Drive-Ins that have been featured on the podcast at:https://www.google.com/maps/d/u/0/viewer?mid=1yJn88ZGUVg73Ui-lPCKOK3OzBulcOIg&hl=en&ll=40.32804053761244%2C-100.05065412604952&z=4For exclusive additional podcasts, videos, sneak peeks, and on-site discounts, visit the Mahoning Drive-In Patreon page at:https://www.patreon.com/mahoningdriveinhttps://www.mahoningdit.comhttps://www.facebook.com/mahoningdriveintheaterhttps://www.instagram.com/mahoningdriveintheaterhttps://twitter.com/mahoningditFor Mahoning Drive-In merch online:https://merchbin.net/collections/mahoning-drive-in-theaterhttps://www.crackerjackposters.com/s/shop

In the first episode of Season 2, co-hosts Thomas Boomhower and Mark Gustavson travel to the Vedder Research Library of the Greene County Historical Society on the Bronck House campus in Coxsackie, NY. They are welcomed by Greene County Historian Jonathan Palmer for a vibrant discussion of the pivotal events and conditions that have shaped our communities, economies, and sensibilities over the past 400 years!

Today on the show I get to sit down with Galen Joseph-Hunter. She has served as Executive Director of Wave Farm since 2002. Wave Farm is an international transmission arts organization driven by experimentation with the electromagnetic spectrum. Wave Farm cultivates creative practices in radio and supports artists and nonprofits in their cultural endeavors. Based in New York's Upper Hudson Valley, Wave Farm is a media arts center, arts service organization, and media outlet operating WGXC 90.7-FM: Radio for Open Ears.Over the past two decades, she has organized and curated numerous exhibitions and events internationally, including "Wave Farm (in residence)" for TuftsPUBLIC at the Tufts University Art Galleries (2018-2019).She was the co-organizer of “Groundswell” an annual exhibition event featuring broadcast, performance, sound, and installation works by contemporary artists conceived within the 250 acres of the Olana State Historic Site from 2013 to 2015.In 2015 and 2016 she curated the Columbia University Sound Arts MFA spring exhibitions.She has produced numerous radio programs for Wave Farm's WGXC and stations internationally including "Climactic Climate" for Kunstradio Vienna (2015).In 2019 and 2020, she organized and led the "Radio for Open Ears" workshop series with 16 and 17 year-olds incarcerated in the Hudson Correctional Facility through CreativityWorksNYS.Galen is the author of the book “Transmission Arts: Artists and Airwaves” (PAJ Publications: 2011,) as well as "Transmission Arts: the air that surrounds us" (PAJ: A Journal of Performance and Art, September 2009: MIT Press).Previously, Galen worked closely with Electronic Arts Intermix (EAI), serving as Assistant Director and then Executive Consultant and now sits on their advisory board. She is the administrator of Regrant Programs with the New York State Council on the Arts and has served as a panelist/reviewer for the National Endowment for the Arts, New York State Council on the Arts, Pew Center for Arts and Heritage, Experimental Television Center, Meet The Composer, New Music USA, Harpo Foundation, and the Greene County Council for the Arts, among others. Galen also lends her time on the Board of Greater Hudson Promise Neighborhood, the Board of Montez Press Radio and is a founding Board Member of New Ear Inc, a New York City-based organization formed in 2024 in response to the energy and success of the New Ear Festival and the spatial sound series CT::SWaM.We get to speak about all of the inspiring work Wavefarm is connected with and supporting including the expanding work in correctional facilities, the newly announced residencies for 2025 and a special upcoming event on May 29th at Hi-Way Drive-In Theatre, Coxsackie, NY featuring Eno on 4 Screens + Fred Frith+ Eucademix (Yuka Honda). We get a peak into Galen's personal life and how turning 50 has her reflecting.Here's your Mystic Mamma Neptune in Aries wisdom and Tanaaz's report on this big shift into Aries.Today's show was engineered by Ian Seda from Radiokingston.org.Our show music is from Shana Falana!Feel free to email me, say hello: she@iwantwhatshehas.org** Please: SUBSCRIBE to the pod and leave a REVIEW wherever you are listening, it helps other users FIND IThttp://iwantwhatshehas.org/podcastITUNES | SPOTIFYITUNES: https://itunes.apple.com/us/podcast/i-want-what-she-has/id1451648361?mt=2SPOTIFY:https://open.spotify.com/show/77pmJwS2q9vTywz7Uhiyff?si=G2eYCjLjT3KltgdfA6XXCAFollow:INSTAGRAM * https://www.instagram.com/iwantwhatshehaspodcast/FACEBOOK * https://www.facebook.com/iwantwhatshehaspodcast

Inversión programada para dos mil proyectos en el 2025: Ebrard  ¡Alerta! Se detectan casos del virus coxsackie en escuelas de Oaxaca: UNAM  Más información en nuestro podcast

Más de 62 mil robos de vehículos en el país, durante este 2024Operativo de seguridad para  productores de limón en Michoacán Anuncia EU que Keith Kellogg será el enviado especial para Ucrania y Rusia Más información en nuestro Podcast

The long-awaited sequel to the 2020 Election coverage, with our team of ace reporters-and-citizens-in-the-field, including New Jersey correspondant Joe Nolan, Mrs. Kinda Needamap from Coxsackie, NY, Vidar Hageman from West Virginia, and international political scientist and Director of the America Only-Friendship Studies Dept (non-social-media division) in Moscow, Russia, Ms. Marina Upintheskya Hatchaplotnik. Learn what it all seems like in New Jersey, upstate NY, West Virginia and Moscow. And settle in for a long week, or months, following the election...

In Episode 9, co-hosts Thomas Boomhower and Mark Gustavson are in the Town of Coxsackie visiting with Steve Gonzalez & Kate Galassi – the proprietors of Via Ravioli.  This boutique manufacturer of fresh pasta products & sauces is rapidly becoming a destination for delicious must-haves for residents and visitors alike. Kate & Steve discuss how they came to love the communities and lifestyle of Greene County, and how they have made life-long friendships with creative entrepreneurs who share their passion and commitment to our local makers, growers, suppliers and support businesses. Have a listen, share with your friends, and don't forget to leave a thumbs up! For more information on who we are and what we do check us out on: Our Website https://www.investingreene.com/ Our Facebook https://www.facebook.com/GreeneCountyEDC Our Instagram https://www.instagram.com/greeneedc/ Extra Special Thank You to Kate & Steve! Visit their website at ⁠https://www.viaravioli.com/theshop Virtual Main Street Tours: https://www.buyingreene.com/virtual

Hello and welcome to our newest episode! We're glad to have you with us. Guys....get ready for a super long adventure filled episode. We tried to contain it, but we just couldn't. There was just TOO MUCH to talk about. On this episode We talk food and snacks a bit, as per usual, and Pumpkin stops by Bent Iron Brewing again to check out a few more brews. We also take Killian out for some driving lessons and Peach gets very nervous, not to mention showing him some questionable driving skills. Then the long adventure weekend begins. We go to Blairstown, NJ and vend an event at the Blairstown Diner to celebrate Friday the 13th. Later that day we trek up to Middletown., NY to visit Fair Oaks Drive-in. Then on Saturday we venture further north to the area of Hudson to visit family. After that, we crossed the Hudson to Coxsackie to check out the Hi-Way Drive-in for their Dead til Dawn Drive-in event. 4 classic horror movies and overnight camping! WHAT A WEEKEND! All those things and more await you. Join us! Don't forget to subscribe to our "It's Not Better, It's Just More" bonus content for a small monthly fee and become part of The Woo Hoo Crew. Check us out on Instagram @pumpkinandpeachpodcast and on Facebook @Pumpkin and Peach Podcast to see pictures and get links to things we discuss in each episode. Now, also check us out on YouTube @Pumpkin and Peach Podcast! Also, our business on Instagram @uglymugsinc and on Facebook @Ugly Mugs Inc. You can also email us at pumpkinandpeachadventures@gmail.com Contact us if you want to collaborate, or be a sponsor.  Also get in touch with us if you want us to try a cider, beer, food, product, or anything and review it on a future episode.

So a lot has happened since we last met... like Eric met THE Biden. As you can tell it was a crazy week for Eric as he traveled across several states and met lots of people including Fred Liu and the Mr.Beast team. Meanwhile Chloe was having an emotional journey rather than a physical one. There's lots of lessons learned this week, including some great advice from Jimmy and Jaime about handling self-hatred and hiring in the creator space.

Happy Tuesday! It's a weather impact day, we review the Connor Stalions documentary, Dabo isn't taking calls anymore, we recap the Ryan Day presser, we chat about Coxsackie, we do Rapid Fire, Man wants to change a law, we have a Fat Boy Food Tip, there's a serial dine & dasher on the loose & it's Game Show Tuesday.

What Fresh Hell Podcast is going on tour across the Northeast US this fall! Join us for a live version of the podcast and bring all your mom friends. We can't wait to go back on the road! https://bit.ly/whatfreshhelltour Parenting is a constant process of choosing the lesser evil. When it's stomach flu or Coxsackie, they're both bad, but when you're playing Would You Rather?, you've still got to pick one. In this episode, Amy and Margaret discuss: What their kids' names REALLY are Rat backpacks The horror of perma-noisemakers We love the sponsors that make this show possible! You can always find all the special deals and codes for all our current sponsors on our website: https://www.whatfreshhellpodcast.com/p/promo-codes/ mom friends, funny moms, parenting advice, parenting experts, parenting tips, mothers, families, parenting skills, parenting strategies, parenting styles, busy moms, self-help for moms, manage kid's behavior, teenager, tween, child development, family activities, family fun, parent child relationship, decluttering, kid-friendly, invisible workload, default parent, Learn more about your ad choices. Visit megaphone.fm/adchoices

Show Notes and Transcript Professor Dalgleish has spoken out about his concerns of the mRNA jab for years. And for the last 2 he has written about the rise of cancers he believes are linked to the jab.  We start by looking back at Professor Dalgleish's career and ask why he chose to speak up and what was the response from his colleagues?  He then delves into this rise of turbo cancers and why he had to sound the alarm despite the struggle to get full transparency from the authorities and "Move on, nothing to see here" is the reply to most requests for data.  His fellow cancer specialists agree with his concerns, but the authorities simply will not listen. Angus Dalgleish is an expert in immunology and Professor of Oncology at St George's Hospital Medical School, London. Article in The Conservative Woman: https://www.conservativewoman.co.uk/massive-cancer-deaths-study-vindicates-my-warnings-over-covid-boosters/ Japan Data: https://www.cureus.com/articles/196275-increased-age-adjusted-cancer-mortality-after-the-third-mrna-lipid-nanoparticle-vaccine-dose-during-the-covid-19-pandemic-in-japan#!/ The Death of Science:      https://amzn.eu/d/2w1wxk4 Interview recorded 15.4.24 Connect with Hearts of Oak... WEBSITE            heartsofoak.org/ PODCASTS        heartsofoak.podbean.com/ SOCIAL MEDIA  heartsofoak.org/connect/ SHOP                  heartsofoak.org/shop/ TRANSCRIPT (Hearts Of Oak) I'm delighted to have Professor Angus Dalgleish with us today. Professor, thank you so much for your time. (Prof Angus Dalgleish) You're welcome. Great to have you. And of course, people will have read, I'm sure, many of your articles, more recently in The Conservative Woman, back before that, I think in certainly The Daily Telegraph and Daily Mail. And since 1991, I know you've been the Professor of Oncology at St. George's University, London. And during this time, you focused on the immunology of cancer and conducted numerous clinical trials involving a variety of vaccines and immune therapy. I know you're well known for your contributions on HIV AIDS research. And of course, you stood for UKIP, which is another part of your story back in 2015. There's so many areas, Professor, I want to talk to you, but maybe you have got a background in understanding vaccines. We'll get on to, I think, the first article you wrote, certainly I read, was back two years ago, actually, on the madness of vaccinating children against COVID, and they started discussing cancer and what you were seeing back in December 2022. I certainly saw it in the Conservative Woman but maybe I can ask you just for a little bit of your background and then we can get on to what you have seen with your patients and the data. Okay well with regards to my background I mean it's, I've been reminded of something I'd forgotten and that is that I'm probably one of the only people in the country who's been an NHS consultant in virology, immunology, general medicine, and oncology. So when I had my chair in oncology, I had a great background in immunology and virology, which is what led me to go into tumour immunology. And I continued working on HIV pathogenesis for several years and worked with colleagues in Norway with designing a very good HIV vaccine, which is the only one that works. But I was staggered that nobody was interested or would support it. And yet the big medical industrial complex, such as the NIH and Big Pharma, kept plowing ahead with vaccines that had the whole envelope in different technologies, and none of them worked. In fact, it was worse than working. They had to stop all these worldwide trials costing billions because the vaccine was worse than the placebo, now so that's a very good entrée as to where I came from with the COVID virus. When that became a pandemic and the sequence became available. I was called up by my colleagues in Norway saying, would I be happy to do the same process? I help identify the major immunological components and avoid all the unnecessary ones, which is the most important thing. And I said yes, obviously. And we started to plan a MAPA plan when they came back and said, this is not an actual virus, this has been released from the lab in Wuhan or escaped then as we put it and the reasons for this was absolutely plain, is that there were charged inserts around the receptor binding site not one or two but six as well as the fusion site, fusion domain and I looked at that you know, and I had a background because I've done so much work on the HIV receptor, even as a clinician I was you know, had a scientific understanding of interactions and what is required etc and it occurred to me that these inserts some of them had been previously published and, you know, by the Wuhan group, they'd said, aren't we clever? We put this insert in and we made this virus more infectious to human cells. This is very good. They went on with two or three. But here we had one with six inserts. Now, my molecular biology, virology friends all told me, oh, don't get excited. All these things happen at random. And here I then realized what a problem was with science, people are only in their boxes, they don't get out of the boxes. Changes in sequence only matter when they translate into the amino acids which translate into proteins and that's what does the interaction, once the amino acids were translated by these inserts they broke all the rules of the game, they were far too too positively charged, which meant that the virus had been altered so it would act like a fridge magnet. So it would zap onto human cells over and above its natural ACE receptor. And when I realized this, it was 100% I was convinced it could not have come from anywhere else because it had broken the rules of biology. And the rules of biology would have edited out those changes because, put it in a simple way, the charge was around pH 8. The charge of any normal virus is around 6 or less. So it was just a supernatural leap. And that's what convinced me. But the big problem was that having written papers in Nature Science, Lancet on HIV and its receptor and how it causes disease and the epidemiology and got them all in the leading papers. When I pointed this out with my colleagues, Nature, Science, all these papers, Lancet, they all turned us down and said, this data is not in the public interest. Seriously, I've got the copies. It is unbelievable. So I realized then that a discussion about the science was being banned. This led to me, and I'm flagrantly admit that, you know, this ended up in us writing a book called The Death of Science, which is actually available, and I've probably got it somewhere. But this was unbelievable that we suddenly realized everything was being censored. I was told by my own university we were not allowed to discuss or research the origin of the virus. Well, I mean, that was really quite draconian. But then where do so many universities get their funding from these days? They're far too reliant on China. So it clearly comes from that source, the way China stopped the WHA doing their work. Now, I'm just going to mention, this is relevant to what you've asked me to talk about, because when we had that spike protein, we realized it was very fully charged. We also looked at it for a homology with now an epitopes. And 80% of it was similar to the human epitopes, some of them unbelievably identical, platelet factor IV myelin. So we said, do not use this as a vaccine, because it will cause all sorts of terrible side effects. This is how you do it. We've learned from HIV, a vaccine is not how much you can put in it, but how little you can put in it. So you go for the Achilles heels of the structure. So if those structures no longer exist, the virus doesn't exist in any variant. So we actually had a blueprint. And we told everybody about this. We had access to the cabinet, the SAGE, Chief Medical Officer of Science. Who basically deemed it all interesting but not relevant. Can you believe that? But they had a point that there was 150 groups reviewed by a Nature paper, all of them so stupid, I use the word advisedly, that they all said, this is our vaccine. They all used the whole spike protein. Well, it was obvious that you must not use the whole spike protein, in the same way we'd spent 30 years saying don't use the whole HIV envelope. And they still haven't got the process. I mean, it is unbelievable stupidity group thing. And anyhow, so we knew there was going to be a big problem if they use the spike protein with autoimmunity, etc. However, that had nothing to do with my interest with cancer at all. What got my interest in cancer in this was when they brought out the booster program. Now, I've done lots of model work on vaccines, you know, basic research funded by charity, done for industry too. And a basic adage is, if a vaccine needs a booster, it doesn't work. So here we are being forced by the government and all the authorities to have a booster when it was all based on the grounds that people who monitor the effects of people who've been vaccinated, their antibody titer falls off. Well, of course it does. I mean, that's what you want. And that was the basis for doing boosters, to stop it falling off. Well, I knew enough then about the booster is that by the time they were talking about rolling out the booster, we were already in Omicron territory. They were boosting a virus that didn't exist on the grounds that there was crossover. And there was all these species, the booster will give you extra protection from crossover. Well, apart from the fact that we'd widely published and it had been downloaded over a quarter of a million times, our objection to using the spike protein and what you should use for a vaccine, with another group of colleagues, I wrote a review of a virus. Coxsackie viruses and the attempts to vaccinate against them and why they had all failed. And actually, the need for them is greater in animal work than it is in humans. But they all fail because the vaccines against coronavirus lead to antigenic sin or immunological imprinting. Once you are vaccinated against a component of that and you challenge with a different variant, it will only see the first component. And it will not see the variants. But it will make antibodies that will bind to them. And then that enhances infection and this explains why people have just woken up scratched their heads and say why does everybody who gets a booster get infected again with COVID in fact three and a half times more likely according to the big Cleveland study and more than twice as likely according to one published after the second vaccine in BMJ, so this was not a surprise. I couldn't believe why nobody heeded and listened to these warnings. And the people that made the decision. It must have made them in ignorance because they certainly didn't read any of this stuff. Otherwise, they'd have been much more cautious. Now, instead, they were being pushed by Big Pharma, who selected the data. It's now obvious that Pfizer, if they had revealed the data, the VAERS data, nobody in their right mind would ever have approved it. And you've had Clare Craig and Norman Fenton on board. So all I can just point out was I was unaware of this carry on at the time, but they brilliantly pointed out that they did it all on relative risk as opposed to absolute risk and the number needed to vaccinate to prevent. If that data had been presented properly, nobody in their right mind would have approved a vaccine. It's just meaningless to have to vaccinate 120 people to prevent one infection. And when the VAERS data came out, it was clear that if you had a serious adverse event, you had a 3% chance of dying. Whereas if you got COVID, you had less than 1% chance of dying. In fact, a lot, lot less than 1% at the very most. So there was no way anybody should have done it. So I would argue that the Pfizer, and I'm not alone in having said that they went into shenanigans and all sorts of smoke and mirror to hide the truth and get everything approved. But, you know, others, such as the state of Texas, are actually suing them for fraud. So, I mean, it's not exactly, it's an open secret. So get back to the booster and the cap.... Could I just ask you just one little sidestep, I remember reading your numerous articles, I think it's probably in the Daily Mail and I remember thinking Professor Angus is saying, speaking his concerns in a great way to stay within certain restrictions and yet get the message out. And I was reading, thinking, this is exactly what I am hearing as a lay person. And you're explaining from your medical professional background. And those articles in the mainstream media, the newspapers, I think were vital in helping people understand what was happening. And you wrote them in such an intelligent, smart way. Well, thank you very much. With regards to the Daily Mail and the articles, I was staggered by the letter. Sometimes they would print a page of letters in the printed edition, and they were all from people saying, thank you so much for helping us understand just what the hell has been going on. You know that was the great thing, the big problem I had with the Daily Mail as soon as I pointed out that there was a problem with the vaccine, I would get to the draft I'd submit it, it'd be accepted and then it wouldn't appear and it had been censored by the chief editor, as soon as it was a vaccine, we now know why, it's because the mainstream media were paid a fortune to push the narrative by the government. A fortune so big that none of them were prepared to challenge it. The Mail did a fantastic job, and I helped as much as I could on the grounds that the lockdowns were madness, and there's no scientific justification for it. It was absolute madness, even to think of a second one. And many others, Carl Heneghan, et cetera, came up, and I was saying that natural immunity, and I was one of the few clinicians to sign the Great Barrington Declaration because that's what I said we should have done straight from day one. In fact, now in retrospect, my gut feeling we didn't need a vaccine program has been proven to be absolutely true because had we done the vitamin D properly and had one or two other drugs out there, we would not, and I include there, without beating around the bush ivermectin, I think Peter Curry's book is absolutely damning how Fauci and others went out of their way to damp that down. And the only reason they did was because you cannot introduce a vaccine if you've got an effective therapy. I mean, I really do believe it was that bad that they were doing this. And so many people suffered. I think it was criminal. I make no bones about that. But the media wouldn't touch my concerns about the vaccine, which is why I ended up publishing them in the Daily Skeptic and the Conservative Women, who, I must say, they challenge anything that they find they cannot collaborate. Corroborate they they check they do their own referencing and everything so they are very very hot and quite a lot of stuff I've had toned down because of challenges to the refereeing for instance etc, but the stuff that they do put out there they're all very happy about it, now what I did and why you were talking is that when the booster came in, I've said it's a complete waste of time. Not only will it induce antibodies to a virus that doesn't exist, but they will lead to more infection. What I wasn't prepared for was that my patients who I was monitoring carefully, who'd been stable melanoma for years, I had half a dozen of them go down within six to eight weeks of the booster program being wheeled out. And they had relapsed. And some of these had been stable for over 15 years. The average was five to seven. And I knew then something was going on because melanoma patients, once they're induced to be stable with immunotherapy like they all had, because I was using immunotherapy 20, 25 years ago, long before it became popular, I knew there had to be a tremendous immune suppression event going on, life event. It's usually bereavement, severe depression, divorce, bankruptcy. Something that goes over three months to cause this. Yet I was seeing it clear. I reported it. I was told by my own people to shut up and stop frightening the patients. There is no evidence. Get the evidence. So I said, you know, I am a canary in a mine and a man with a red flag. It's up to everybody else to react to this. Now, I was told no. I've subsequently seen a dozen and I've continued to shout. And I saw eight cases within my social and family circle of people who developed leukaemia lymphoma after the booster and so we started to say how is it doing that? When it became evident there was a very good, I mean my own group have done work on this, but to me what really convinced it when other people found that t-cell responses were suppressed after the booster not the first and second but after the booster and the t-cell suppression was so bad they called it exhaustion in cancer patients, well we know that the people who've got cancer under good control, it is t-cells nothing to do with antibodies. So the booster was doing more harm than good, it's suppressing the t-cell response, and then I found papers that was even worse on the grounds that the booster switched the IgG1, immunoglobulin class structure antibodies, from ones that would normally be intent on fighting viruses to one that were tolerizing them, tolerizing the IgG. The sort you induce in transplant patients. So not only had you switched the T cell response off, but you'd sent all the antibodies on to be tolerizing so they didn't reject the transplant. Of course the transplant in this case is the cancer so there's no doubt that it popped up, that was a major reason why it popped up, now why it's important to discuss this now is, having been told to shut up and be quiet, I did get by the way, people from all over the world saying thank you for pointing this out, we've seen exactly the same thing. I mean from America, Canada, South America, Europe, South Africa, Australia, all around the world people said we're seeing exactly the same thing. Well now we have this paper that's come from Japan, it's pure statistical analysis of events over COVID, including all causes of death and this is important, not incidents death, and they noticed there was no increase in death of any cause or cancer during the first one and two waves of COVID. But it started in late 21 and continued to rise, hardly doubling in 22. And so the all-cause in 21 went from a few percentage, three or four, to over 9% in 22. Death from cancer went from 1.1 to 2.2 + in 22 these are small figures but it's a very strong trend because it was in all the cancers, it wasn't just in any one and I got particularly interested because there was no great increase in colorectal cancer, which is what we've seen in the UK in fact the colorectal surgeons were the first to phone me and say we're seeing unbelievable colon cancer in young people, and they've all had the booster vaccine. You know, we think there is something related. So I reacted that there was no signal in Japan. And then remember, they have an incredibly different diet. It's a completely anti-inflammatory diet. So they haven't been primed for colon cancer to take off. But all the ones that were killing them were those that killed them before, but much quicker. But I mentioned mortality. I predicted there would be a massive increase in cancer problems just on lockdown alone because we weren't screening. People weren't coming to with their symptoms. We weren't doing the scanning. We weren't getting them on treatment early. So that alone, I predicted more people would die of that lockdown on cancer than would die from any benefit of lockdown on COVID deaths, which we now know there were zero. I mean I think most people will now agree with that, it was introduced far too late on both occasions, it was introduced just as the hot, the waves were dying out, completely utterly pointless, so I was very aware and actually preached a bit that you know, the problem with this issue is cancer incidence is massive, cancer deaths not nearly as much because we've got very good at treating it and the incidence to death can take several years, so here in Japan you've actually got the death rate clearly rising, it's all very statistical this, in one year two year now, That was finished in 2023, submitted in 2023. If we had the 23 data, I would bet that that would be a doubling again, probably, on the 22 data, because they have shown in the data they've got, it's worse with each booster, not just the first. If you have a fourth and a fifth, it gets worse. And what is great about this paper is it goes into explaining how it's actually induced the cancer early as opposed to just waiting for it to develop which is what I would have expected had it just been suppression of the immune system and one thing they have suggested, which I totally go along with and I hadn't thought of it first-hand myself but I'm fully aware and support it, is that the clotting tendency, these micro-clots that the spike protein causes. Actually would lead to enhancing the cancers to spread and metastasize. And we know that this clotting abnormality occurs in some cancers, prostate and pancreas, and all sorts of unusual things occur, like disseminated intravascular coagulation, etc. Now, this is the sort of thing, that it was being reported in people who died of cancer who'd been vaccinated. Really abnormal clots. If you look at the literature, there's a lot of people pointing out that the autopsy is highly unusual clotting going on. So the fact that that process was actually driving cancer is a very interesting suggestion. It's not proof, but it's yet another reason that might be driving it. In the literature are reports that the spike protein binds to p53 and msh3. These are suppressor genes. If you have mutations in these genes you're much more likely to develop cancer because they normally switch the cancer that has arisen by accident off. They're suppressor genes, they switch it off. So if you compromise your suppressor genes you're much more likely to develop cancer quickly. And I think that this is part of what the Japanese data is showing. I just point out that I don't think there is any ulterior motive in just pointing out what we've seen, whereas I am very concerned that the Office of National Statistics keep changing the rules with data. They stopped reporting the COVID deaths in May 22, and they've been doing adjustments and all sorts of things, which I think, what are they trying to hide? And Carl Heneghan has made a very, and Norman Fenton, made a very big issue of this. Why don't they just release all the data? And I'm convinced that data shows something very similar, just because of what I see. I look around my friends, the number who've gone down with cancer since they had the booster. Which they only had so they could travel in lockdown, and they wanted to have a decent holiday. And he said, you can't get on this plane or this boat unless you have the booster. And so they had the booster. And in two cases, they never, ever going to get on the boat and do the traveling. One of them died very quickly, and I was horrified by it because he'd had perfect treatment, absolute perfect treatment, but still progressed, suggesting there were other mechanisms going on. And another one had a lymphoma that he had years ago it resurfaced rapidly and killed him and his oncologist, I was quite surprised told him, I really can't ignore the fact that this has been stable for years but it's come back as soon as you had the booster and there's a chap in England who's pointing this out, I was a friend of this guy, he's in America. And then I've had other cases which have popped up completely unexpected. In my family, I've had cases of leukaemia uncovered after the boosters and brother-in-laws, etc. So it's really real. And friends who developed aggressive prostate, pancreatic, ovarian cancer since the booster program has been wheeled out. And my main reason for shouting about this is that I am still being told I can have a spring booster to protect myself. I spoke to a friend today and they were talking about their father who was told he had prostate cancer and I think he went for a psa testing, that's to look at how far the cancer is and it was very low it was six or eight, then after the boosters he went for another test and they'd gone up to 170 and was told it spread throughout out the body and that was it and I get those are similar stories you have heard and I'm looking at these studies which are coming out and obviously you, this has just come out, you've just published this in the conservative woman as of when we're recording actually on the 15th, but you need studies I guess to analyse the data and put it together it's one thing having the individual stories, but these studies seem to be telling you what you already had heard in your individual patients. Yes, indeed. I mean, we've been really waiting for proper studies like this, and there seemed to be a real hesitation. I mean, I told everybody who criticized me, well, go away and look at it. You're sitting on the data. You're head of trusts. You're head of of MRC, CRUK, all these things. That's your job. It's not my job. My job is to be the whistle-blower. But as we know, whistle-blowers in the health service are persecuted, and it would have seemed to be the same in science and everything as well. It's been going on a long time. I was reminded yesterday that Semmelweis, who was the first person to point out that the dreadful sepsis deaths in the maternity ward were due to the fact nobody washed their hands, and if you washed their hands, you didn't get it. All his colleagues turned around and said, you're a lunatic, and had him locked up. I mean, I don't think things have changed with this pandemic at all. That's exactly what's going on. It's the death of science. nobody wants to discuss the data whether it be the origin of the virus whether it be with a pandemic it's a good or bad thing whether it be that masks are a good or bad things or that whether we should have been able to early treat as you would any respiratory virus with a good boost of vitamin D, soluble aspirin, intranasal interferon, beclamide, if it goes to the chest all these things I believe, and ivermectin which having looked at all the data, I can understand now why nobody in the establishment wanted it anywhere near a COVID patient because it worked and it saved them and there would be no need for any vaccine whatsoever and Fauci demonized it as a horse de-wormer when it is probably one of the most effective drugs in humans ever in the history of medicine, because it It prevents all sorts of things, river blindness and the liver, all the flukes, et cetera, in Africa and Asia. And may well be a major reason why the incidence of COVID deaths in these places was so low, because they were all on ivermectin and getting good vitamin D, of course. I've just spoken out as these studies are coming out, and we'll put the link to the Japanese study in the description. Of course, it's in that article. As more and more people have spoken out, are you seeing more of your colleagues going public on it? Because surely when the studies are coming out, the data is released, then that's proving what has happened. And therefore, you will get more and more people from the medical community who actually are speaking up and saying, yeah, this is correct. Do you think that will happen? Well, I hope so. I hope so. So the ones that spoke up and said, you're correct, all said, by the way, we've been told to shut up too and not upset the patients. This is like it was a central script written somewhere because they told me the same in America, Canada, Australia, Europe and Britain, that to be quiet. I got carpeted for pointing all these things out and said I was breaking NHS guidelines. And this would go down on my thing as breaking rules. I said, I don't give a damn. All I'm doing is making sure I do no harm. I suggest you do the same. NHS is causing more harm. I think the NHS, one of the reasons it's crippling, it's spending so much time treating the side effects of the vaccine program. And they won't admit it, of course. And I've been doing some medical legal instances where people have clearly been damaged by the vaccine and none of the people concerned will admit it. They just say coincidence. It's just like a tape. And I've spoken to lots of people who had very bad vaccine and had just been really badly treated. They go out of the way to make sure it's not enough for compensation. And I hadn't realized how many people had lost their jobs in the UK because they refused to get vaccinated or they refused to get the booster because they had had such bad bad side effects from the first two. How can you possibly justify that? If you have a bad reaction to a drug, you don't take it again. You don't take another dose and hope it's not as bad this time, which seems to be the NHS and the government's attitude to it. Yeah. Another part is the cancer issue, and obviously seems to be speeding up cancer much faster. That's certainly the people I've talked to. But the other side, and a lot of the media reports have been a shocking cancer amongst younger people. And the journalists, right, they have no idea why…. Yes, they do. this has been happening recently but I mean tell because, it's that concern you think cancer is something you get maybe later on in life but this is happening younger, this changes the very nature of what that is the impact on society. Yes I mean we have seen and there there is a paper showing that there is a real increase in patients under 44. I think it's 19 to 44 a massive increase in cancers and particularly abdominal cancers. So colorectal. We were seeing this before, by the way, in young people in this country, obviously not in Japan. And so I've always said it must be something to do with the diet is driving this, and so do most people. But it seems to have accelerated since the vaccine program came on. But we're seeing all the others. I mean, I was really surprised. We're seeing oesophageal cancer, biliary, liver, pancreatic, upper and lower bowel, weird ones like appendix cancers. You know, incredibly rare. I was contacted by a fellow who said that he'd seen about one of these. He runs a colorectal surgery and he's seen about one in the last five years. And he said, I've seen 13 recently, and they'd all had the vaccine. They were all in young people. So, I mean, so when people get cancers, unusually unexpected. The first thing you should do is say, why? Do they have something in common? Well, they do. The vast majority, again, not all of them, because there's a background incidence, have all had the vaccine or a booster. And that to me is stop the bloody program now, you know instead I'm being told to go and get my spring booster what planet are these people on? This is, since you've spoken up nearly or 18 months or 21 months ago I've seen more and more people write about it, is this the end then of this worldwide experiment of this new type of technology, this mRNA which is massively backfired or is it just how Big Pharma work and then they come up with the mRNA now to fix cancer which is the the latest thing we've heard. Yeah, well, they were always working on that. And I actually, you know, when people tell me I'm a clinician and I don't know what I'm talking about and to shut up, I tell them I know a darn sight more than they do. And especially about the dangers of messenger RNA vaccine, because I was on a scientific advisory board for a company whose subtitle was the messenger RNA vaccine company for five years and I left about seven years ago and they were targeting cancer and they didn't get through, BioNTech had the same thing. Big Pharma and whatever's behind them at far more sinister, has used this pandemic and I mean, when it started I wouldn't even have thought along these lanes. I honestly think it was planned, it's like it was planned to get the messenger rna out, when you go back and you look at the Manhattan project for vaccines and world health, their big issue was why do we make all these vaccines? If we don't have a pandemic we won't make any money, we'll lose money so this really looks like it was all planned, why did Moderna have a patent on sars-2 in February 2019? Why did the German government go ahead and fund an an enormous big vaccine facility in Marburg to produce messenger RNA, long before they were anywhere near being approved. It sounds like the whole thing was part of some sinister plan. And that's what I find really, really concerning. And I've spoken up and on the record. I think the messenger RNA vaccines are an absolute disaster, should be banned. They should be completely, utterly banned. And they are what they say on the till in the early BN Biotech preparations for Pfizer, they have COVID vaccine-gene therapy. Well, that was honest. You don't use gene therapy on a pandemic that kills less than 1% of people. And then you go ahead with the plan, when you know that the people who did die had an average age in the UK of 82, whereas average age of anybody else dying of anything else was 81. So the logical thing for a statistician was to go around and prepare COVID and spray it all around the population and tell them they'll live an extra year longer, because you've got I mean, being very cynical about it. But why would you? You shouldn't do it. Chris Whitty occasionally said some sensible things, but then went on to being beheaded or whatever it is and go along with this madness. He said, you can't use a vaccine unless you've got a death rate of 30% in the main population. You can't justify it if you haven't got the safety data. Why did he not stand up when it was 1% and stop it? Could it be something to do with shut up and you'll get your rewards in the honours list which they all did these people all of them, Vallance, Whitty and all these, I was going to say goons from SAGE, I'll say that again I do, I disagreed with them totally and utterly and even the people working with the vaccines from Oxford, the Astra Zeneca, they all got knighthoods, damehoods everything long before there was any evidence it was of any any benefit. It's unbelievable. When these studies come out, a lay person like myself will think this then starts a catalyst of looking at other countries and wanting the data. But then the flip side is you realize the difficulty of data, and you touched on that. I think you had mentioned that whenever I saw you speak at Andrew Bridgen's event the end of last year in Parliament, the lack of data. It seems like there is British data. there is Israeli data and there does seem some Japanese data. Many other countries seem to have a complete void, but the UK government don't even want to release any of the data. Will this force them to release it? Will this mean there are possible financial penalties? I mean, these companies getting sued? Where does this go whenever one country brings out a study like this, which is so comprehensive? Well, I think you'll get other countries that will do it. I really do. I mean, Australia, who behaved appallingly during the pandemic, I mean, they were run by a bunch of, not just clowns, but really ghoulish clowns who seem to relish in power and locking down and God knows what else, have mandatory vaccines. Well, at least they have. They've had a lot of revolt over this, and they finally had a formal Australian Commission on Excess Deaths. And I've been asked to give evidence for it as have some other people who've raised their voice and we'll make it very very clear what's going on, some of the senators now in Australia know exactly what was going on and they're baying for blood as it were and the thing that I'm baying for, why were the people like me in Australia and I worked in Australia for seven years by the way, I did flying doctor for a year and I did internal medicine and oncology. I know it very very well, why did these doctors who thought like me, I'm going to look after the patients, this, that and the other, they got struck off if they they wouldn't go along with this madness. I mean, it's unbelievable. It was inhumane. And at least that commission is going to uncover it. I think our COVID inquiry is a whitewash to kick the can down the road for so long. By the time it comes to the conclusions, nothing to see here, nobody, no one person was guilty. There'll be lessons to learn. No, there won't be any lessons to learn unless they hold people to account, unless we withdraw from the WHO, this madness, this treaty they want us to sign up to, once they're all signed up, they release the next pandemic and they will have another round of vaccines for you. I mean, I thought this was absolute madness to even think like that. But George Orwell saw it all 70 years ago, 70 years plus. And I mean, it's just unbelievable. I re-read 1984 and Animal Farm when I went on holiday recently. They had a package, and I'd read them 40, 50 years ago, a long time. If I hadn't have read them, I'd have thought, oh, somebody's seen through the lockdown and written these in lockdown as to where it could lead once you give the power to the governments to bully the thing. Yeah, it's incredible. They could have been written in the lockdown, but he wrote them 50 years ago. He saw what was coming. Obviously, it was about the communist model coming out of Russia and the implications. But I never thought I would live long enough to see democracy being destroyed by the same tentacles of control that emerged due to the COVID. And it's given them a power to interfere in everything else. I mean, a power to block all kinds. I've lost my faith totally in justice in the UK, probably worldwide. The Postmaster scandal was unbelievable. when the guy was told you're the only one, I remember that's what I was told when I made a great fuss, you're the only one, it transpires there were dozens and dozens of us who made, said the same thing to the government, they ignored, there were hundreds and hundreds of postmasters who said the same thing that they ignored and now, you know we're going we're having the same absolute nonsense over climate control. I mean I went and researched climate control, I didn't have to do much research before I realized that the data is very clear out there that carbon dioxide rises when the world warms. And it is actually something that's trying to do something good about it. And it does. It's a heavy gas, falls to the ground, encourages plant growth, tree growth, which produces more oxygen. It is. It's like a controller. It's like a thermostat. It is not the cause. And you've got all these morons, and I use the word advisedly, and people like Ed Miliband should springs to mind this guy is a total moron, who thinks that if you stop the co2 from the cars, this, that and the other, you'll save the world from global warming, it won't make one iota difference and if you really succeeded in lowering co2 significant, you would actually start extinguishing life they don't seem to understand any basic biology at all and yet these morons are running our parliament, running our lives and they are impoverishing everybody on this planet. I saw my energy bill even though we tried very hard, it's absolutely ludicrous and it's even worse knowing it is five times higher than if I was in the United States where at least they've got some pragmatism with regards is, we can't do everything in the solar and wind we're going to need our oil and gas and by the way it's beneath us, ours is beneath us but we've basically said we're not going to use it and so we're dependent on China who's polluting the world to death, it's unbelievable. I think many people have had their eyes open to many of these issues over the last couple of years of COVID tyranny. Professor Dalgleish, I'm honoured really to have you on, it's wonderful to hear your thoughts and your writings, it's good to delve into them, people can get the Conservative Woman, but thank you so much for the stand you've taken and thank you for sharing your thoughts with us today. Right. Well, thank you very much for having me. But just remember, we've written an enormous amount of this up in The Death of Science, which is available on Kindle, Amazon, and is multi-author. And it's got contributions from Karol Sikora, Sir Richard Dearlove, Clare Craig, Ros Jones. I mean, I'm really proud that we've been able to really put the gauntlet down, that this government and the world's governments and the scientists and the institutions and the medical profession have killed science. We have to do everything we can to rectify that. Thank you. And the viewers and listeners can get that. The links will be in the description. So however you're watching, however you're listening, you can just click on that. So, Professor, once again, thank you for your time today. Cheers. Thank you.

In Episode 3, co-hosts Thomas Boomhower and Mark Gustavson let the Catskills out of the bag at UnQuiet – Antiques, Interiors, Insubordination in the Historic Reed Street Business District in Coxsackie, NY. Owner/Visionary Sarah Gray Miller has created a truly eclectic shopping destination and gathering place just across the street from the Hudson River. Sarah Gray takes us on her journey from magazine editor and Greene County weekender, to her hard pivot to retail and hospitality in a riverfront community on the rise. Have a listen, share with your friends, and don't forget to leave a review on your platform of choice. For more information on who we are and what we do check us out on: Our Website: https://greenecountyedc.com/ Our Facebook: /greenecountyedc Our Instagram: /greeneedc Extra Special Thank You to Sarah Gray from UnQuiet! : https://www.unquietupstate.com/

We learn the keys to preparing delicious and memorable seafood dishes with Dominick Purnomo and Chef Ian O'Leary. And we get a sneak preview of the Day Line restaurant which will be located on the roof of the soon to open James Newbury Hotel in Coxsackie. Call with your seafood question, tip or recipe. 800-348-2551. Ray Graf hosts.

Can caffeine and cannabis give you a boost of energy to feel more alert, productive, and really good? Science says, yes it can! There's a reason why this combination is my favorite way to start the day. I cover the different ways to infuse your morning coffee, or tea and some interesting coffee products I've seen available for purchase. Recipe: Cannabis-infused Coffee | Includes complete steps and amounts for how to make a low-dose canna milk for your coffee . FOLLOW @FRUITANDFLOWER // SUBSCRIBE FOR MORE RECIPES TRY IT: PRODUCT SPOTLIGHT If you'd like to try a CBD and coffee combo in your coffee beans, get 20% off your first order of Deva Coffee with code “FRUITANDFLOWER.” Seattle, Washington based Deva Coffee is a woman-owned, mission driven company roasting hemp CBD bubble-hash infused specialty coffee. SPONSORED BY MOODRXTREATS MoodRXtreats is like adult summer camp… with lots of weed! Luxury wellness retreats for womxn who love cannabis and want to meet and connect with other like-minded rad womxn in a judgment-free space. In 2023, there are three destination experiences in Hopkins, Michigan in June, Coxsackie, New York in August, and Ellicottville, New York in October. 15% off when you book with promo code “FRUITANDFLOWER.” More info at moodrxtreats.com and @themoodrxtreats.

The girls are back to talk about the Super Bowl and the tragic loss of the Eagles (wah!). They discuss their Valentine's Day dates (Toto and 4 course meals). But the real attraction in today's ~explicit~ episode is the special guest appearance by their good friend Dave.Dave is a seasoned Richmond guitarist who has performed in several successful bands around Richmond - one of them currently being Guinevere (https://www.facebook.com/GuinevereRVA/). The girls were once vocalists in his Journey/Foreigner cover project and can attest to his art of shredding on his Stratocaster.Any-who, Olivia and Liz interview Dave about his musical history which started in New Hampshire when he was just a 15 year old boy inspired by ACDC's guitarist Angus Young. He talks about his first garage band with his sister on vocals and playing at parties on the third floor of an old uninsulated house. It was there they wrote their first hit song, "The Cat Shit On The Floor" (based on true events). Genius!Other topics include Richmond venues where Dave has played (old and new), strippers, COXSACKIE!, Slash, a biker gang encounter, Ozzy Osbourne, a swearfest, MONKEY MAIL DOT COM, Dave's Jessica Alba doll, Virginia HAM HAM HAM!, castrato, Olivia's Gregorian chant, guitars, live patients shipped to the morgue, HIT HER GRANDPAW!, and they all guess Lee's name.Catch Dave in Guinevere on April 8th at Flatrock Sports Bar and Grill in Powhatan, VA.Richmond peeps! Need a space to record? Want to learn how to play guitar? Do your lyrics need music? Our own Lee of Dungeon Studios can help. Find him on Facebook at https://www.facebook.com/lee.church.Follow us on Instagram @olala_RVA and Facebook https://www.facebook.com/olalainthedungeonrva.Byeeee! :)

In this episode of Dumbing it Down with Dave amongst other things Dave talks about the November 8 election of 2022.

En Morelos, se han reportado casos del virus de Coxsackie, el cual ha infectado a niños en el municipio de Cuautla, donde tuvieron que suspender las clases por el aumento de contagios.

Got an opinion? If you're listening on the iHeartRadio app, tap the red microphone icon to record & send us your thoughts. Don't have the app? Get it free here ---> https://news.iheart.com/apps/ Follow WGY on social media: instagram.com/wgyradio twitter.

One of the huge downsides of motorcycle road racing is that we lose some to bad crashes. It was a difficult day at Brainerd on July 29, 2022 when we lost a really good man in Scott. His daughter Darian was there and it was an extremely horrible day for her as the crash happened in front of her. About 12 days later I was doing Scott's Memorial Service in Coxsackie, NY. It was quite a turn out and there was a lot of love shown the family.  Here is a portion of the service.

Join me this week for a short but sweet spooky road trip around the Selkirk area!

Community Gardens are a timely topic for this episode where you'll hear from Kim Bender and Eliza Spear on the how the Community Garden in Coxsackie, NY was founded and maintained. They also touch upon the very popular Coxsackie Farmer's Market. Then learn all about irises with Linda Levitt (Flower Power).This episode concludes with coral being the color of the day in a conversation about Heuchera and Native Honeysuckle on the latest Cover Up segment with Jean Thomas and Tim Kennelty.  Enjoy! Hosts: Tim Kennelty and Jean Thomas Guests: Kim Bender and Eliza Spear Photo by: Tim Kennelty Production Support from: Linda Aydlett, Teresa Golden, Transcript and Resources

Join Ed for OBs verbal tour of South Jersey in this quick Sip from the Tap.  If you know the answer to the cliff hanger let us know.  

This month on Episode 35 of Discover CircRes, host Cynthia St. Hilaire highlights two original research articles featured in the April 1 issue of Circulation Research, as well as highlights from the Stroke and Neurocognitive Impairment Compendium in the April 15th issue.  This episode also features a conversation with Dr Shubing Chen and Dr Yuling Han from Weill Cornell Medical College to discuss their study, SARS-CoV-2 Infection Induces Ferroptosis of Sinoatrial Node Pacemaker Cells.   Article highlights:   Pabel, et al. Effects of Atrial Fibrillation on the Ventricle   Pattarabanjird, et al. P62-Mediated B1b Cell Atheroprotection   Iadecola, et al. Introduction to the Compendium on Stroke and Neurocognitive Impairment   Cindy St. Hilaire:        Hi and welcome to Discover CircRes, the podcast of the American Heart Association's Journal, Circulation Research. I'm your host, Dr Cindy St. Hilaire, from the Vascular Medicine Institute at the University of Pittsburgh. And today I'm going to be highlighting articles from our April issues of Circulation Research.                                     I'll also speak with Dr Shubing Chen and Dr Yuling Han from Weill Cornell Medical College, and they're with me to discuss their study, SARS-CoV-2 infection induces ferroptosis of Sinoatrial node pacemaker cells.   Cindy St. Hilaire:        The first article I want to share is titled, Effects of Atrial Fibrillation on the Human Ventricle. The first author is Steffen Pabel and the corresponding author is Samuel Sossalla and they're from Regensburg University. Atrial fibrillation, or AFib, is the most common form of heart arrhythmia. Patients with AFib may experience shortness of breath, dizziness and weakness. And they're also at risk for more life-threatening complications, such as clot-induced stroke and heart failure. Focusing on heart failure, this study investigated how disruptions to rhythm in the atria might lead to changes in the ventricular myocardium. The team studied ventricular muscle tissue from 24 patients with AFib and 31 without AFib. While the levels of fibrosis were equivalent in ventricular myocytes from both the AFib and the non AFib patients, other cellular features were distinct. For example, patients with AFib had reduced systolic calcium release, prolonged action potential duration and increased oxidative stress, compared with the non AFib patient controls. These differences were largely recapitulated in ventricular myocytes derived from human induced pluripotent stem cells that had been electrically stimulated to either mimic AFib or normal sinus rhythm. The results indicate that AFib affects the ventricles just as well as the atria and might therefore be best studied and treated with the whole heart in mind.   Cindy St. Hilaire:        The second article I want to share is titled B-1b Cells Possess Unique bHLH-Driven P62-Dependent Self-Renewal and Atheroprotection. The first author is Tanyaporn Pattarabanjird and the corresponding author is Colleen McNamara, from the University of Virginia.   Atherosclerosis is a complex and dynamic chronic inflammatory condition. However, not all immune cells exacerbate this disease. Some immune cells are actively dampening the inflammation. B-1 cells are such cells that do this, and they produce IgM antibodies that bind cholesterol, preventing its uptake into macrophages and therefore limiting macrophage driven inflammatory responses. Increased number of B1 cells, therefore, might be atheroprotective. In mice, deletion of the transcription factor ID3 leads to a boost in B-1 cell IgM production.   Cindy St. Hilaire:        In this work the authors investigated the molecular mechanism underlying this effect and found that upon deletion of ID3 in mice B-1b cells, the level of P62 protein was increased. B-1b cell proliferation was found to be dependent on P62 and over expression of P62 in mouse B-1b cells increased cell numbers, raised plasma IgM levels and importantly, ameliorated diet-induced atherosclerosis in animals. The team went on to show that people with an ID3 mutation had an unusually high level of serum IgM and B-1b cell P62. This suggests that results from mice may hold true for humans, and if so, could inform the development of immunomodulatory treatments for atherosclerosis.   Cindy St. Hilaire:        So the April 15th issue of Circulation Research is our Stroke And Neurocognitive Impairment Compendium. The last Circulation Research Compendium on Stroke was published about five years ago. In this year Dr Costantino Iadecola, Dr Mark Fisher and Dr Ralph Sacco focused this update on advances made over the past five years, with a focus on topics that were not addressed in the previous compendium, that best reflect the leading edge of basic in clinical science related to cerebral vascular diseases. Seemant Chaturvedi, Brian Mac Grory and colleagues provide an overview of preventative strategies according to stroke mechanism, including stroke of unknown cause. And the challenges of stroke prevention with antithrombotic therapy and subjects with increased hemorrhage risk are also considered.   Cindy St. Hilaire:        Stéphanie Debette and Hugh Markus provide an account of the most recent developments in the genetics of cerebrovascular diseases. The gut microbiota is another factor that has recently been linked to stroke risk and Pedram Honarpisheh, Louise McCullough and colleagues provide a comprehensive overview of the microbiology and the microbiota, and the influence that stroke risk factors exert on its composition and homeostatic relationship with mucosal surfaces. Karin Hochrainer and Wei Yang provide a systematic review of the large amount of data and stroke proteomic from animal models and human patients. Matthias Endres and colleagues cover the dramatic effect that innate and adaptive immunity exert on stroke risk and on acute brain damage and post stroke sequelae, such as post-stroke cognitive impairment and depression.                                     Cindy St. Hilaire:        Manuela De Michele, Alexander Merkler and colleagues discuss the cerebral vascular diseases that have emerged as a frequent manifestation of the maladaptive immune response to severe SARS-CoV-2 infection. Jessica Magid-Bernstein and Lauren Sansing review the current concepts on epidemiology, risk factors in etiology, clinical features, as well as the medical and surgical interventions for cerebral hemorrhage. Yunyun Xiong and Marc Fisher cover the progress that has been achieved in the treatment of acute ischemic stroke and Natalie Rost and Martin Dichgans and colleagues address the long term impact of stroke on cognitive function, which is becoming a significant healthcare challenge in the world's aging population.   Cindy St. Hilaire:        So today I have Dr Shubing Chen and Yuling Han from Weill Cornell Medical College. And they're with me to discuss their study SARS-CoV-2 infection induces ferroptosis of Sinoatrial node pacemaker cells. And this article is in our April 1st issue of Circulation Research. So thank you both for joining me today.   Shubing Chen:             Thank you. It's really nice to join the program, and it's really a great honor.   Cindy St. Hilaire:        It's a really great article. I'm so excited to talk about. So there's a lot of research happening regarding SARS-CoV-2 virus and the patients who are infected and have COVID-19. And this paper is focusing on the impact of viral infection on the heart and specifically on the sinoatrial node, which is the primary cardiac pacemaker that keeps our hearts beating. So I was wondering if you could tell us what led you to focus on this particular aspect of COVID-19 symptoms, and also how early in the pandemic did you start this?   Shubing Chen:             Yeah, so we started working on SARS-CoV-2 through back to early 2020 when very unfortunately, New York City was a pandemic center and we had a lot of patients in the hospital unit, and also postdoc students working very hard in the lab. So that's the time we start working on SARS-CoV-2. And I was trained as a stem cell biologist. And what we're really interest is to set up a platform to basically understand which type of cells can be infected by SARS-CoV-2 and if they can, how they respond to SARS-CoV-2 infection. Not only for SARS-CoV-2, we sent it as like a viral infection platform, but SARS-CoV-2 is one of the virus we study now. And it's kind of very surprising. We have a pretty broad platform. We have a lung organoid, we have colon organoids, we have pancreas, we have cardiomyocytes, pacemaker cells. And as expected, we see lung can be infected like colon and because patient had GI tract, liver can be infected, but very surprisingly we see very high cardiomyocytes infection as well as pacemakers.                                       So as we'll know that still big controversy in the field, whether we can detect SARS-CoV-2 like viral protein or viral RA in the heart, in particular, cardiomyocytes. But I think now everyone agree that the cardiomyocytes really can be very well infected actually. Because it's very difficult to get the pacemaker tissue and the sinoatrial tissue from the COVID patient. So we collaborate with Dr Ben Andora's lab at NYU to get this hamster model. So we basically take SA tissue from hamster and then other colleagues basically did the section imaging, and we confirm that the hC4 polymerase cells can be infected by SARS-CoV-2. And at that time we start to learn a more clinical studies they report the COVID patient, they develop arrhythmia, or some other problem, not only with cardiomyocyte, as well as the conduction system. So at that time, that's the time that we say maybe we should do something on the pacemaker and focus on that. So that's how the project was developed.   Cindy St. Hilaire:        That is so interesting. And so I know humans infected, like you just said with SARS-CoV-2, they can develop arrhythmias. What's that timeframe? Is there a common timeframe that this happens? Does it normally happen very close to the infection or only in later stage? What's that window of when these arrhythmias are happening?   Shubing Chen:             At least based on the clinical study we show right now, actually the patient can develop acute arrhythmia. So it can be very soon after they developed symptom for COVID.   Cindy St. Hilaire:        Wow. That's amazing. So you mentioned this, your study utilized a hamster model, which you actually don't see a lot of. Most studies use a lot of rats or most studies I'm familiar with, especially in Circulation Research, they use more rats or more mouse models. So what advantages does that hamster model have and why were you interested in using it?   Shubing Chen:             Yeah, that's actually really specific for SARS-CoV-2. As SARS-CoV-2 mainly use ACE2 as a key entry factor to enter the cells. Of course, there's additional receptor, like neutrophils is one. Like all this enzyme involved, but human and mouse ACE2, they have very different structure. So the SARS-CoV-2 virus combine with human ACE2 very well but not mouse ACE2. So from the beginning, the rat and mouse was not used as a very good model to study SARS-CoV-2 infection. Of course there are other models, like knockin human ACE2 in the mouse and also like ACE2 transgenic mice. That's how different mouse model use. But hamster you don't need any modification, but they are very promising to SARS-CoV-2 infection. And so that's a reason we decide to use that as an animal model to basically run in parallel with our human stem cell model.   Cindy St. Hilaire:        We joke in my lab, mice are not little humans, but it's really true in a lot of cases, they're beautiful models in so many ways, but then when they don't work, they really don't work.   Shubing Chen:             Yeah. Before COVID every time when we try to talk about our human stem cell, derived cells, organoids as a disease model. People always ask, why do you want to work on human organoids? Right? It's that we have all these beautiful animal models like as you mentioned, mouse or rats, that's very broadly used. And we have to find different reasons. And now when we start working on SARS-CoV-2, which is very clear example, that mouse are not identical to human. Yeah.   Cindy St. Hilaire:        Yeah. That's great. I love finding additional models to use that are the best one for the question. So in order to investigate, I guess kind of the mechanism of how this was happening in the SAN cells, the sinoatrial node cells, you had to develop a new differentiation protocol that took the human embryonic stem cells, I think it was the H9 line you used, and essentially differentiate that cell line into a sinoatrial node-like cell. So I was wondering if you could tell us a little bit about A) how did you figure out that protocol and B) how does it work?   Shubing Chen:             So it's actually a long story to cell line.   Cindy St. Hilaire:        We can condense it. Let's get-   Shubing Chen:             At least based on the clinical study we show right now, actually the patient can. Let's condense it. But it's as you can imagine, we did not develop this cell line only for this particular project. Actually, we start working on this cell line back to maybe six, seven years ago. The first postdoc we have who basically knockin the mCherry, Myh6. Which basically label the atrial cardiomyocytes. And another postdoc, Zanir, he basically put a GFP in the SARS2 locus. So now we have this duel reporter line we can visualize the SA nodal cells. And we really spend a lot of time on that because we think that unfortunately in our hand, there is not really no good antibody for SARS2. We think it's very, very important that you can see these cells. So after developing these lines and because my lab run a lot of chemical screening, where we run Zanir, we run several chemical screening to develop the protocol.                                       And Jialing Zhu, another postdoc in the lab, also pick up the project to further develop the protocol. And there is several years' work. We do have this good protocol to make pretty efficiently to make the cells. And it's not only our work. I want to say that. For example, Dr Sean Wu from Stanford, they did this beautiful study on the single cell RNC mouse conduction system and Dr Gordon Keller and many other labs also basically published protocol in the field. We are very excited about this duel reporter line. I think they gave us a lot of new opportunity and we are very happy to share this line. Yeah. So if anyone in the field are interested in that, just contact us.   Cindy St. Hilaire:        Yeah. Anyone listening. That's great. So were you surprised to find the entry factors that SARS-CoV-2 uses to get into a cell, were you surprised to find them on these sinoatrial node cells? And I guess in the context of comparing these particular cells to other cells in the heart, are those entry factors higher in the sinoatrial node cells?   Shubing Chen:             So it can be either surprised or not surprised let's say this way. So because one, we see the cardiomyocytes that can be infected, we were kind of surprised. And then we find actually several type of cells in the heart can be infected, like endothelial cells. I will say that the ACE2 expression of like ACE2 aminophenol in pacemaker cell, it's not significantly higher than cardiomyocytes. So we are not really saying, or seeing that SA nodal cells are more permissive to SARS-CoV-2 infections compared to cardiomyocytes, even in the petri dish, but they can be infected.   Cindy St. Hilaire:        So you found SARS-CoV-2 infection in these sinoatrial nodal cells induces a process called ferroptosis. So Yuling, I was wondering if you could tell us what is ferroptosis and what is it doing in these pacemaker cells?   Yuling Han:                 For the ferroptosis, they was surprised so far that its by the RA sequencing of the SARS-CoV-2 infection make our cells. And the first process is mainly caused by the-   Shubing Chen:             Error in iron.   Yuling Han:                 Yes. So more intake of the iron error and induced the RA's pathway and caused the cell deaths. So by our RA sequencing, we found the key factor involved in ferroptosis pathway is the GPS score was checked after the SARS-CoV-2 infection. So we focused on the ferroptosis pathway and found other key factors or checked after the infection makes in the pacemaker cells.   Cindy St. Hilaire:        What is the ferroptosis doing that disrupts the SNA cells?   Shubing Chen:             Ferroptosis is a type of cell death mechanism. So eventually it will cause cell death. And we think something that is really surprising, but we think it's very interesting, is we only see ferroptosis in the SARS-CoV-2 infected general atrial cells. So SA cells, we actually, as Yuling mentioned, when we develop this platform, we see different type of cell can be affected. And we are very curious what happened. So we see that we run a sequence on each individual cells we can see infection and along, we can see cell death like apoptosis in cardiomyocytes. We see apoptosis and only in SA nodal cells, we actually see the ferroptosis pathway as we come up.   Cindy St. Hilaire:        Why do you think that is in that cell type versus in another? Do you have any ideas about why?   Shubing Chen:             No, we don't have any idea yet to be honest, but we are working on that. But at least I think that it gave us some clue that we really need to use different type of whole cells to study the whole cell response. Because traditionally when we study viral infection and when we see lung, we always say, oh, the cell died. It's fairly simple. But now if we really study the details and we think it's maybe over simplified way to think about how cells can respond to viral infection, not only to SARS-CoV-2 infection. So it gives us the motivation, very strong motivation to now really study how different host tissues response to viral infection.   Cindy St. Hilaire:        I thought that was really interesting, not all cell death is the same.   Shubing Chen:             Yeah. And another thing is kind of a little bit surprising is we actually did a very careful comparison between the SA nodal cells and the cardiomyocyte. We only see ferroptosis come up as SA nodal cell, but not cardiomyocyte. Again, we don't understand why as maybe some host factor that is specific, we're working on that.   Cindy St. Hilaire:        So in addition to working out this mechanism of what is going wrong when these cells are infected with the virus, you also used this embryonic stem cell like tool for a drug screen. So can you walk us through that process in terms of what you did to do that? Did you focus in on one specific type of drugs or was it just kind of an unbiased screen?   Yuling Han:                 For the sinoatrial pacemaker cells, we focus on the antiviral drugs screening. And we also did several other projects, like lot of night or some neuron cells. For the [they did drug screening to find some drugs to inhibit the SARS-CoV-2 entry. And for the dominic neuron, we found SARS-CoV-2 infection can cause neuro cells synapses. So we focus on the synapses associated drug screening, but for the pacemaker cells, they only did the antiviral drug screen.   Cindy St. Hilaire:        And you came up with two drugs that you wrote about in the paper, deferoxamine and imatinib. So what are the mechanisms of action of those drugs? Are they targeting the same thing or are they targeting slightly different things?   Yuling Han:                 For the imatinib, we also found this drug inhibit SARS-CoV-2 entry and we did several other screenings, like the lung organoids and neuro cells. We also found this drugs. And the six drug, the mechanism is kept and the spec protein of SARS-CoV-2. And this was found by several other groups and published some paper this year. And we found this in 2020 maybe. And we published this paper before and we found this mechanism. And for another drug, we checked the RA sequencing data of SARS-CoV-2 affect the peacemaker cells. And we did several run of RA sequencing. And we compared the key factors, involved in SARS-CoV-2 entry. Several key factors like CTSL and like TMPS2 and among several run of RA sequencing. We only found the drug can decrease the expression of CTSL. So we also did PTR immunostaining, and then we found the drug decrease the expression level of CTSL.   Shubing Chen:             Yeah. So actually the other drug, it's also an antiferroptosis drug. So we did the mechanism study and it's very nice to see, we also identify the drug from an unbiased chemical screen. And for the chemical screening, we actually have a pretty large platform and we have around 1200 FDA approved drugs. We have like a 2000 anatrofin amino acid that signal pathway regulators for most of the SARS-CoV-2 screening, as you did mention, we have multiple screening platform. We focus on FDA approved drug. So it's more like for the drug repurposing and for other screening we also write larger skills.   Cindy St. Hilaire:        So we got a mechanism, we got a super specific cell type and we now have some drugs. So what are the translational implications of these findings? And I guess I'm thinking about that in terms of the time course of when a patient gets infected, has symptoms, has arrhythmia, like where could you possibly target this ferroptosis pathway? Meaning if someone already is exhibiting AFib as a result of the infection, is that actually too late? Or can you start to treat it to reverse it or prevent it from getting worse? Like what do you see as a therapeutic potential for using these drugs?   Shubing Chen:             That's a very good question. I will say this way, I think when we identify all these drugs, it's very, very exciting. But for antiviral drug development perspective, we definitely want a drug that show broader spectrum. So for COVID patient, of course we want to protect their heart, but we also want to protect their lungs.   Cindy St. Hilaire:        Exactly. Protect everything.   Shubing Chen:             Exactly. Exactly. So for the real drug that can clinical use, I think the lack of broad spectrum antiviral drug, I think that will be the way to go for drug development and for the cardioprotective respective. So if the patient do have very severe cardio symptom, particularly like arrhythmia symptom, I think that can be considered. But I don't want to really say this is the drug to treat the COVID patient. I don't think that's a way to go, particularly for ferroptosis is a cell type. This is a phenotype, very specific for the pacemaker. And I think for us, as a basic scientist, is very, very important that we understand the biology and we can identify these normal chemical tools that we can manipulate the system that can facilitate the future drug development.   Cindy St. Hilaire:        So do you think your findings and I mean findings at multiple levels, that a viral infection can induce apoptosis in one cell, but ferroptosis in another cell, but also the findings of viral infection in general, sufficient enough to drives sinoatrial node cell dysfunction. Do you think this is specific to SARS-CoV-2 and corona viruses or do you think this is something that is more broad with other viruses that maybe we just haven't recognized possibly because we don't have the tools yet?   Shubing Chen:            That's a great question. I will say some other type of virus can also infect heart, at least cardiomyocyte, like a Coxsackie virus, regular virus three. And there's actually a lot of study on the viral infection on the cardiomyocytes. And for us, the most exciting part is we really have now in serious, limited starting materials to get these pacemaker cells. Like I SA nodal cells. So we can use this as a platform to study how other virus infect, how the viral infection in general cause cell dysfunction. Because in the study we also do the calcium blocks assay, we can monitor their beating and then we can do RN-seq to monitor their transcription changes. Because this we have this still reporting system, we can purify cells, we can even run larger scale, like epigenetic level, how they change. So that's a very useful tool to study how cell responds to viral infection. I'm very excited about that.   Cindy St. Hilaire:        That's great. Well, Dr Chen and Dr Han, thank you so much for joining me today. Congratulations on a beautiful story. And I look forward to hearing more out all these different organoid and cell models you have.   Shubing Chen:            Cindy, thank you. Thank you for so much for having us.   Cindy St. Hilaire:        That's it for the highlights from the April issues of Circulation Research. Thank you for listening. Please check out the CircRes Facebook page and follow us on Twitter and Instagram with the handle @CircRes and #DiscoverCircRes. Thank you to our guests, Dr Shubing Chen and Dr Yuling Han. This podcast was produced by Ishara Rantikac edited by Melissa Stoner and supported by the editorial team of Circulation Research. Some of the copy text for highlighted articles was provided by Ruth Williams. I'm your host, Dr Cindy St. Hilaire, and this is Discover CircRes, you're on the go source for the most exciting discoveries in basic cardiovascular research. This program is copyright of the American Heart Association, 2022. The opinions expressed by speakers in this podcast are their own and not necessarily those of the editors or of the American heart Association. For more our information visit ahajournals.org.  

We're back! Enjoy this new episode and many more coming in 2022! In this episode of the Hotel Design Podcast, we welcome Glen Coben, President and Owner of Glen & Company. Coben is a huge driving force within the hotel design community, and brings a unique point of view from the retail environment where he previously worked with Nike. They start by discussing his background, and how stories are told in various sporting cultures globally. Coben reveals how he keeps things fresh by continuing to add to his project's design dialogue. Take an example regarding how he designed two different Italian restaurants and how his firm focused on ensuring that each one was distinctly unique. The goal: Be unrecognizable in the work from one project to another, since each is a wholly different experience! Coben and Glenn also discuss the Adelphi Hotel in Saratoga Springs, NY, where Coben shares the story of revitalizing the last remaining grand hotel in Saratoga Springs. The five-year hotel renovation project took on a life of its own, finding inspiration from existing classic interiors, without reinventing them. For example, original crystal serving dishes were turned into a beautiful backdrop behind the front desk to create a sense of place and time. The firm also reinvented the floor plan, expanding small out of date bathrooms into much larger spaces, and cutting the room count almost in half during the process to create a more luxurious property. Coben, it turns out, loves complicated and intricate types of design projects like that one. Glen and Company also created the Pestana – a modern property inspired by Portuguese roots – which is located in New York City. The unique part of this design was their approach to heightening the feel of space in a footprint limited in size. We learn how Coben and his team were able to create the illusion of space, along with some of their great design tips. He also focuses on how to be disciplined when it comes to creating a coherent and streamlined story from which the hotel's design is built upon, specifically by sharing examples from the Archer. They discuss reinventing space to accentuate the dining experience by bringing it into the hotel, rather than hiding a restaurant where people do not actively see it. He also shares the story of how this hotel was based on a made-up character named Archer who loved art, music, and travel. They used this narrative to create a space that connected back to their envisioned Archer. Another project is the James Newbury Hotel in Coxsackie, NY - an old structure on the banks of the Hudson River in an industrial town. To reinvent this hotel, its history was the inspiration for its future, and Coben shares how they chose the elements of design to tell the story for this property. Once it has opened, it will have 46 rooms that connect to an older structure that houses the spa. Coben also discusses reinventing how guest rooms are laid out to change the focal point of the experience. Coben ends with his thoughts on how he knows when a building needs to be taken down and completely redone and when it can be upgraded. He says that young designers can become better storytellers by not relying on social media, but by going out and experiencing life and new spaces. He says that we must put the story on paper and keep looking at the details. Follow along with some great project visuals on our website - http://hoteldesignpodcast.com/ - and subscribe to our new Youtube page to watch the video interview!

Nas últimas semanas, Lauro Müller registrou casos da Síndrome Mão, Pé, Boca em crianças da rede municipal de ensino. A doença contagiosa é causada pelo vírus Coxsackie e é mais comum na infância, antes dos 5 anos de idade. Em entrevista ao Cruz de Malta Notícias desta terça-feira, dia 5, a médica pediatra Graziela Nasario Aragona explicou que a doença tem esse nome devido às lesões que surgem, comumente, nas mãos, pés e boca das crianças e alguns dos sinais característicos são febre alta nos dias que antecedem o surgimento das lesões, mal-estar, falta de apetite, vômitos e diarreia, entre outros. “É uma doença que não tem notificação compulsória, porém, dois ou três casos de infecção por esse vírus já é considerado um surto”, frisou. “A nossa microrregião está acometida pelo vírus”, completou Graziela, que relatou o registro de casos em Orleans, São Ludgero, Braço do Norte, Criciúma, além de Lauro Müller.

We may never know for sure if Ryan Fitzpatrick injured himself while at a water park with his family know that will never happen to the Giannotti family due to Gio's distain for such a place, we eventually get to the bottom of Gio's hatred for water parks and it all stems from being a fat little boy, before Jerry's update we heard from another Greg - this one was an adult who has Coxsackie, Al Dukes and 'the' Eddie Scozzare visited the same Urologist once upon a time, Thursday's highly anticipated 'Moment of the Day' was next, a member of 'Team Boomer' checked-in with an emotional call, some mullet love and an apology.  Get into it already!!! See omnystudio.com/listener for privacy information.

This Sunday, July 18 at 4 p.m., The Spencertown Academy Arts Center will present beekeeper Sheri Bauer in an online event entitled “SymBeeOtic: Embracing a Life with Bees.” The event is presented in collaboration with the Austerlitz Climate Smart Task Force. Earlier this week I met Sheri and some of her bees at the Twin Spruce Apiary in Coxsackie, New York.

Brian and Connie celebrate 50 BWYF episodes with a review of newfangled slang, time-traveling Obama, Coxsackie, Ben Franklin's confidence, and the most dangerous game. Music: Floppy Disks by Shane Ivers – https://www.silvermansound.com --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app

The title says it all, this isn't for the squeamish. This is what happens in prison, no good, all bad and ugly. Watch Laz tell it here. The Greene Correctional Facility is a state prison for men located in Coxsackie, Greene County, New York, owned and operated by the New York State Department of Corrections and Community Supervision. The facility opened in 1989 and holds 1582 inmates at medium security, which includes 171 held in a maximum-security unit. Greene is adjacent to the state's Coxsackie Correctional Facility, originally built in 1935. Violent felony offenders housed at this jail are responsible for the death of numerous other inmates while in custody at this facility. The inmates at this facility are also responsible for numerous assaults on staff.

We once again return to the Hudson Valley with the very awesome Sun Voyager. Our cipher is shooting the shit with Carlos and Stefan, the least of which includes the legacy of Tony Hawk's Pro Skater, having a moment for The Castle, finding tactical residence in New Jersey, blazing out to Ecstatic Vision's demo, the rewarding and frustrating aspects of being too heavy for psych and too light for doom, bloody nights in New Paltz, why they jacked and ditched their original name, playing the Melt Asia Festival with Raekwon while their drummer "pulled a gun" on Pete from The Adventures of Pete & Pete, Coxsackie cranks, craft beer, the missing bass head story, and more!Support Sun VoyagerTrack featured is "Open Road" off Seismic Vibes

Greene is often referred to as the wildest prison in New York State. In one of his more amazing stories Laz shares a story of two guards that will leave you literally shaking your head. Watch Laz tell it here The Greene Correctional Facility is a state prison for men located in Coxsackie, Greene County, New York, owned and operated by the New York State Department of Corrections and Community Supervision. The facility opened in 1989 and holds 1582 inmates at medium security, which includes 171 held in a maximum-security unit. Greene is adjacent to the state's Coxsackie Correctional Facility, originally built in 1935. Violent felony offenders housed at this jail are responsible for the death of numerous other inmates while in custody at this facility. The inmates at this facility are also responsible for numerous assaults on staff.

When serving a six-year sentence, one will see many memorable things. Few of those will be as memorable as the tale of the green suede boots at the Greene Correctional Facility. Watch Laz tell it here The Greene Correctional Facility is a state prison for men located in Coxsackie, Greene County, New York, owned and operated by the New York State Department of Corrections and Community Supervision. The facility opened in 1989 and holds 1582 inmates at medium security, which includes 171 held in a maximum-security unit. Greene is adjacent to the state's Coxsackie Correctional Facility, originally built in 1935. Violent felony offenders housed at this jail are responsible for the death of numerous other inmates while in custody at this facility. The inmates at this facility are also responsible for numerous assaults on staff.

Laz observed an instance where making prison weapons went all the way wrong, while he was doing a six-year sentence. During his sentence, he served a portion of it at the infamous Greene prison. Watch Laz tell it here. The Greene Correctional Facility is a state prison for men located in Coxsackie, Greene County, New York, owned and operated by the New York State Department of Corrections and Community Supervision. The facility opened in 1989 and holds 1582 inmates at medium security, which includes 171 held in a maximum-security unit. Greene is adjacent to the state's Coxsackie Correctional Facility, originally built in 1935. Violent felony offenders housed at this jail are responsible for the death of numerous other inmates while in custody at this facility. The inmates at this facility are also responsible for numerous assaults on staff.

In the life and times of St.Laz, our hero's journey has seen many twists and turns. When he was doing a six-year sentence he served a portion of it at the infamous Greene prison. While there he once saw an inmate have boiling hot grease thrown on him. The Greene Correctional Facility is a state prison for men located in Coxsackie, Greene County, New York, owned and operated by the New York State Department of Corrections and Community Supervision. The facility opened in 1989 and holds 1582 inmates at medium security, which includes 171 held in a maximum-security unit. Greene is adjacent to the state's Coxsackie Correctional Facility, originally built in 1935. Violent felony offenders housed at this jail are responsible for the death of numerous other inmates while in custody at this facility. The inmates at this facility are also responsible for numerous assaults on staff. Watch Laz tell it here.

In the life and times of St.Laz, our hero's journey has seen many twists and turns. When he was doing a six-year sentence he served a portion of it at the infamous Greene prison. The Greene Correctional Facility is a state prison for men located in Coxsackie, Greene County, New York, owned and operated by the New York State Department of Corrections and Community Supervision. The facility opened in 1989 and holds 1582 inmates at medium security, which includes 171 held in a maximum-security unit. Greene is adjacent to the state's Coxsackie Correctional Facility, originally built in 1935. Violent felony offenders housed at this jail are responsible for the death of numerous other inmates while in custody at this facility. The inmates at this facility are also responsible for numerous assaults on staff.

In the life and times of St.Laz, our hero's journey has seen many twists and turns. When he was doing a six-year sentence he served a portion of it at the infamous Greene prison. In this episode, Laz details a hectic situation on the rec yard. The Greene Correctional Facility is a state prison for men located in Coxsackie, Greene County, New York, owned and operated by the New York State Department of Corrections and Community Supervision. The facility opened in 1989 and holds 1582 inmates at medium security, which includes 171 held in a maximum-security unit. Greene is adjacent to the state's Coxsackie Correctional Facility, originally built in 1935. Violent felony offenders housed at this jail are responsible for the death of numerous other inmates while in custody at this facility. The inmates at this facility are also responsible for numerous assaults on staff. Watch Laz tell it here.

In the life and times of St.Laz, our hero's journey has seen many twists and turns. When he was doing a six-year sentence he served a portion of it at the infamous Greene prison. The Greene Correctional Facility is a state prison for men located in Coxsackie, Greene County, New York, owned and operated by the New York State Department of Corrections and Community Supervision. The facility opened in 1989 and holds 1582 inmates at medium security, which includes 171 held in a maximum-security unit. Greene is adjacent to the state's Coxsackie Correctional Facility, originally built in 1935. Violent felony offenders housed at this jail are responsible for the death of numerous other inmates while in custody at this facility. The inmates at this facility are also responsible for numerous assaults on staff.

In the life and times of St.Laz, our hero's journey has seen many twists and turns. When he was doing a six-year sentence he served a portion of it at the infamous Greene prison. The Greene Correctional Facility is a state prison for men located in Coxsackie, Greene County, New York, owned and operated by the New York State Department of Corrections and Community Supervision. [1][2][3][4] The facility opened in 1989 and holds 1582 inmates at medium security, which includes 171 held in a maximum-security unit. Greene is adjacent to the state's Coxsackie Correctional Facility, originally built in 1935. Violent felony offenders housed at this jail are responsible for the death of numerous other inmates while in custody at this facility. The inmates at this facility are also responsible for numerous assaults on staff. Watch Laz tell it here.

April 14, 2002 was the last day Coxsackie, NY, resident George Knauer was able to see.  On that day he collapsed in his apartment as a serious infection and high fever permanently damaged his optic nerve, plunging him into darkness.  George not only survived his illness, he even returned to his work as a plumber and wrote a book about his experience entitled Suddenly Dark.   George shares with Fr. Scott his perspective on how to live with joy and purpose despite his circumstances and how we can all choose to prevail no matter what.

Episode #50 brings Mr. Ryan Naccarato Athletic Director and Dean of Discipline at Coxsackie - Athens School District (NY) and the Founder of Hudson Valley Ambition (HVA) a mobile Fitness Training Service in Kingston NY Area. Ryan shares his experiences in teaching, coaching, and fitness. He also discusses HVA and the great things this service is doing for people as we all continue to battle the pandemic. Wanna continue the conversation, or show your support for the show? Use the social handle @IronDreadPod and discuss the show! Make a post or story share and get a shout out on next week's show! Weightroom Song of the Week Playlist: https://open.spotify.com/playlist/1KO6TDvLgxh1FCP49d415o?si=oFG2bwT2R9KtIbf9CpqaXg Follow Ryan on Facebook: Ryan Naccarato Facebook Group: Hudson Valley Ambition Instagram: @Hudsonvalleyambition Email: hudsonvalleyambition@gmail.com www.hudsonvalleyambition.com Follow the Show: @IronDreadPod Follow Coach Chris Whittaker: @Coach_Whittaker66 on Instagram & @Coach_Whittaker on Twitter and @Irondread_sc Talking about the Show on Social Media? tag @irondreadpod to give us your feedback Sponsors: Crank It Up Dj Service @Crankitupdj_dancing Instagram @CrankitupDJ on Twitter and on Facebook Anchor: @Anchor Theme Song: “The Vengeful One” by Disturbed https://open.spotify.com/track/3jjU4Pky1ja5J1onU6ei4T?si=JTU9xkeKTzC9Q2T9H8wr5A --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app

What Fresh Hell podcast co-creators Margaret Ables and Amy Wilson will tell you: the best recipe for a successful online content marriage is when one is an Idea Cannon and the other knows her way around a spreadsheet. Together, they've converted their careers as writer/performers and complementary business savvy into millions of downloads and a full slate of advertisers. Join us as we discuss how they augment the podcast with video and live shows, how their business and content strategies have evolved over their four years together, and how all parents can work together to keep the pandemic from drumming moms out of the workforce.

Today I am joined by Kristen Schindler, Host of the All The Things Podcast.  Kristen is a mom, author and entrepreneur with a servant's heart who wants to uplift and encourage others.   Today she speaks about the imaginary audience, and about listening and responding to the signs that we are given.  In this episode, you will hear the remarkable story that unfolded a year after she wrote the 15th chapter "Gratitude Pie" in her book  All the Things that takes us to the other side of the world.Kristen Schindler lives with her husband, Eric, and her children in southern Illinois. She was born in upstate New York where much of her extended family and favourite people still live. She loves to go back to the river town of Coxsackie, New York where her heart feels like it is being simultaneously cupped and warmed. Pieces of her heart, like breadcrumbs, have been left in various places throughout the world where she has met and found chosen family and dear friends.  She has always loved to listen to other people’s stories and share her story with others. She loves to see the connections and richness that communication and an openness to others' hearts and experiences brings to the fabric of our lives.  Her mission in life is to show up authentically, vulnerably, and listen to the hearts of others. She is continually reminded that despite her desire to keep a firm grasp on all things she would like to control, God has positioned himself to do the driving of her life. She is merely a passenger.Free download  https://kristenleeschindler.com/homeschoolingFacebook Page 3-day Bootcamp: All the Things with Kristen Schindler. This is a great way for parents new to the homeschooling world or who just want to really get a good vision for their upcoming year, can tap into. Click here to Donate to the Sri Lanka Project https://kristenleeschindler.com/giving   

From the age of 17, Big Mike didn't know what freedom felt like for over 20 years. He opens up with Pete about his earl years at Rikers and going up north. From beefs over phone time to full scale brawls, getting stabbed in the lung, kidney, and stomach to near death. Pistol and Mike relive how they were at the center of the infamous Coxsackie prison riots. Mike shares how after 10 years behind bars a visit from his Mom changed his entire perspective on how he would finish out his bid and turned his life around. Mike is a shining example of how to never give up on yourself as he transformed form a guy breaking heads behind bars to a husband, father and supportive son providing for his family everyday in the working world.

Johnny Hincapie a Colombian native and New York resident, was wrongfully convicted of murder in a case that rocked NYC in 1990. Johnny was released in 2015 after 25 years in prison and eventually exonerated in 2017. He shares his powerful story with BailStreet.  2:00 1990 Brian Watkins Murder 4:36 1980s Crime in the USA 5:00 NYPD Detective Carlos Gonzalez 6:54 Carlos Gonzalez Cont. 7:44 Interrogation 8:10 Trusting Authority and NYPD 9:25 Downstate Processing Center/Coxsackie Correctional Facility 11:45 No Criminal Record  12:00 Corrections Officers - Rikers Island 12:52 Coxsackie correctional facility - Racist Officers 14:20 Prison Transfers 15:28 Family Support & Faith 16:22 No Support Early On 17:25 Serving 25 Years. One Month. 3 Days 18:00 Theater Group - Beginning Of Struggle For Release 19:20 Bill Hughes - Writer Gets Introduced 20:00 $1 Dollar Bail Story Explained 21:00 Immigration Attorney--Julie Goldberg 23:11 Central Park Five Case 26:00 No Program For Exonerees 28:30 Innocent Inmates 30:20 Story of Innocent Inmate & Suicide 31:46 Changing Policy 33:04 Finding Hope In Prison--Law Library Help 35:27 17 Years In Prison - Reopened Case 36:23 Prosecutor ADA Corruption 35:42 9/11 In Prison 36:00 Almost Recruited By Marines _ DESERT STORM 37:00 Friend Is A Cop - "A lot of us are really corrupt" 37:19 Still A Die Hard New Yorker 38:00 George Floyd Case and Police Defunding 39:00 Police Policies Have To Change 39:43 Hold Cops Accountable 40:50 NYC Cops--72 Hour Rule Should Change 41:10 False Confessions-"They'll Make You Say Anything" 42:00 Defunding The Police 42:47 Stats on Free College and Stats on Police 43:31 Low Police Standards 43:40 Watkins Family 46:00 Hincapie Social Media PLUG 46:00 Movie Rights - Flown To Hollywood  47:10 Acting and Social Justice Work 49:00 One Police Officer Could have Stopped It All 50:20 In COLUMBIA - Two Daughters 52:00 UNIVISION TV DEAL 54:00 1st Exoneree Actor for Social Justice   Johnny Hincapie Social Media: Twitter: @Johnny_H72 Facebook: https://www.facebook.com/JohnnyCHincapie/ Youtube:https://www.youtube.com/channel/UC0kCHoW36Ggn-wChdWP-qjw Instagram--https://www.instagram.com/itsjohnnyh72/

Dr. Carolyn Lam: Welcome to Circulation on the Run, your weekly podcast, summary and backstage pass to the journal and its editors. I'm Dr. Carolyn Lam, associate editor from the National Heart Center and Duke National University of Singapore. Dr. Greg Hundley: I'm Dr. Greg Hundley, the director of the Pauley Heart Center at VCU health in Richmond, Virginia. Dr. Carolyn Lam: Oh, Greg. Today we have a special episode focused on COVID‐19 pandemic, something that has just affected us so severely worldwide, it really needs no introduction. Why are we doing a special issue? Well, I think it very quickly got recognized that patients with cardiovascular disease do seem predisposed to severe COVID‐19 syndrome, and that these patients can have an acute COVID‐19 cardiovascular syndrome, in fact. We're going to be talking all about this in a series of interviews about the syndrome, the clinical presentations, what this implies for management. Is the pulmonary embolism involved in the pathophysiology of all of it? And what are ways that we should use to monitor or even screen these patient?, For example, what's the role of troponins? Dr. Greg Hundley: Yes, Carolyn. I am excited, just as well as you, and our first paper today is from Dr. Leslie Cooper, from the Mayo Clinic. He's really done a nice review describing the disease process and the management of acute COVID‐19 and the cardiovascular syndromes. Dr. Greg Hundley: Leslie, we'd like to welcome you to Circulation on the Run and just to get started, I'm wondering, could you tell us a little bit about the genesis of your paper and then also perhaps some of the mechanism, how does this virus affect our systems and promote cardiovascular disease? Dr. Leslie Cooper: In mid‐March as the COVID, crisis was taking off in this country, I was on a telephone call with Dr. [Biykem] Bozkurt and [Dr. Mark] Drazner, from Texas. We realized that there was a terrific need for clinicians to have an overview of how to manage the COVID‐19 impact on the heart. There was also, at that point, very little clinical data about the mechanisms and what the real pathogenesis was. We set about and the rapidly put together the available world's literature. That is what was ultimately published here in Circulation about two weeks ago. Dr. Greg Hundley: Tell us a little bit about that mechanism. Dr. Leslie Cooper: It became apparent that there is not one specific mechanism. We initially thought that like the Coxsackie viruses, this could be a direct cardiac damage, but clinically as we reviewed the literature, it became clear that it's more systemic. The older patients who have preexisting cardiac disease, hypertension, coronary disease, other risk factors, such as diabetes or obesity have a much greater risk of cardiac involvement and the consequences of that cardiac involvement are very substantial. Dr. Leslie Cooper: In addition, when you get a profound cytokine storm from the systemic infection, that can depress cardiac function. A combination, in individuals, of cytokine mediated damage from systemic inflammation, stress induced cardiomyopathy, as you would see in takotsubo, as well as hypoxia and perhaps increased pressures in the lung from, as Carolyn mentioned, pulmonary emboli, and finally direct viral damage. Viruses can infect macrophages in the heart. There is a growing body of literature that there can be a direct effect independent of the systemic infection. The answer is there are multiple factors each of which may have its own therapeutic target. Dr. Carolyn Lam: Oh, I love the way you explained that so clearly Leslie, and in fact, this is really bringing back sweet memories of when I was training under you at Mayo Clinic. I won't say how many years ago, but there comes the question, you know so much about myocarditis, in general, and a different viral myocarditis. Could you maybe tell us a little bit about how this one may or may not differ and also how this impacts management? Dr. Leslie Cooper: The coronaviruses have a very different mechanism of cell entry and propagation. It does not appear that this particular infection in the heart is causing the kind of antigen specific immune reaction that you see classically with a Coxsackie virus. We're not seeing necessarily a lot of auto‐antibody, molecular mimicry. We're not seeing a lot of T‐cell infiltrate. We are seeing some infection of macrophages, and it's not yet clear how many of those were infected peripherally and then migrated to the heart. The histology is quite different and the acute damage is therefore, more subtle. You're not seeing sheets of lymphocytes and the targeted therapies would not be necessarily directed at those cells. Dr. Leslie Cooper: Having said that, inflammation more broadly, for example, anti‐IL‐6, anti‐IL‐1 type, anti‐cytokine mechanisms are currently under evaluation in clinical trials, and they may be quite meaningful. Quite meaningful in the setting of the systemic inflammation. When you compare this to a SARS and other coronavirus infections, I'd like to say, we have known that occasionally a coronavirus can cause myocarditis, for 40 years. It's simply not very common. It predisposes the individual or makes the particular virus more cardiovirulent at this point. Dr. Carolyn Lam: All listeners, you have to get ahold of this beautiful paper. As Greg was actually suggesting a little bit earlier, they're this beautiful figure that you have to refer to that shows a management pathway and considerations. Also, very lovely illustrations of potential mechanisms. Leslie, could you also let us know then, in the overall management, not just treatment, where is the place then, for things like myocardial biopsy? Dr. Leslie Cooper: I think you have to start with the clinical presentation. COVID‐19 as a syndrome, and SARS‐CoV‐2 as a virus, can present with multiple cardiac syndromes. The first would be ST segment elevation, like myocardial infarction with normal coronary arteries. In that setting, it may be microvascular obstruction, or it could be myocarditis or stress cardiomyopathy, perhaps in a younger person who doesn't have risk factors. Dr. Leslie Cooper: Can also present with a primary cardiomyopathy, a heart failure presentation, shortness of breath, systolic dysfunction. And finally it can present as a pericardial effusion, not the most common presentation, but it's important to realize that just like other viruses, this can cause an epicardial or pericardial inflammation. Dr. Leslie Cooper: Management really depends on the clinical syndrome and I'd emphasize guideline‐directed medical management. If it's an arrhythmia, a ventricular tachycardia or heart block, manage that per the current guidelines. The same is true for systolic heart failure. Dr. Leslie Cooper: In addition, I would say that since most patients with COVID infection do not have cardiac involvement, you should first treat the whole patient. First, see the clinical syndrome. What is the dominant problem? Is it a lung problem? Is it kidneys? Then, if there is a cardiac manifestation, we recommend starting with a troponin. If the troponin is elevated, proceed to a point of care echo. Dr. Leslie Cooper: We do want to minimize exposure of allied health staff and physicians to the virus. We do not recommend multimodality imaging or heart biopsy upfront. Having said that, if the patient has substantial left ventricular systolic dysfunction, and they're already in the cath lab, because you're excluding coronary disease, our paper does recommend that you consider an endomyocardial biopsy to find the mechanism of left ventricular dysfunction. Dr. Greg Hundley: Very good, Leslie. Dr. Greg Hundley: Could you close this out, a little bit about therapy when we have patients with this severe hypertension, respiratory abnormalities requiring ventilation, and then also these devastating cardiovascular effects. Are we looking at anti‐inflammation is primarily the target as opposed to antiviral therapy? Dr. Leslie Cooper: Right now, there are a couple of clinical pearls. Number one, as in all cardiogenic shock, you don't have... Sinus tachycardia is not a therapeutic target. You may need that because of low stroke volume. You want to allow when it's compensatory for the tachycardia. Once you've treated with guideline directed therapy, the arrhythmias and the cardiomyopathy appropriately, specific mechanistic interventions, such as antiviral therapy or anticytokine therapy should be given within the context of a clinical trial, wherever possible. Dr. Leslie Cooper: Our article recommends that if you have access to a clinical trial and in this country, the convalescent plasma trial, is up and running. Mayo is leading that for the country. It's available at approximately 600 sites. We would recommend, first of all, enrollment in a trial because we then will understand the mechanisms and the best treatment. If you don't have access, it really depends on the clinical syndrome and how sick the patient is. Patients who are less sick have been treated with things like hydroxychloroquine. People who are more sick, we move on to a convalescent plasma and anticytokine therapy such as tocilizumab. Dr. Greg Hundley: Very good. Well, Leslie, we want to thank you for sharing this wonderful review with us at Circulation. We feel very privileged to have the opportunity to publish this and also to share it with our readership. Again, thank you for all of your frontline work at the Mayo clinic and helping participate in trials and things of this nature to combat this terrible disease. Dr. Leslie Cooper: Thank you so much. Dr. Carolyn Lam: Greg, from acute COVID‐19 cardiovascular syndrome to now, all about troponins. I am so, so thrilled that Dr. Nicholas Mills is here with us, not only our associate editor, but also corresponding author of the next paper. He's from University of Edinburgh in UK. Nick, I love the question that you asked in your title, "Are troponins an ally or a foe in the fight against COVID?" Explain, please. Dr. Nicholas Mills: I strongly believe that they can be an ally, but I recognize amongst cardiologists and clinicians around the world that are grappling with this new condition, that the use of biomarkers can be contentious. We're still learning very much about this condition and how it affects the heart. Therefore, it's difficult to provide very clear guidelines. It's how you interpret the cardiac biomarkers in this condition. The reason I feel strongly that they can be an ally is, they're easy to measure, they're cheap, and you don't require a direct patient contact to obtain the result of the test. It gives us some fundamental information about whether the heart is involved or not. Dr. Greg Hundley: Nick, can you tell us which biomarkers do you favor and is it high sensitivity troponin? Is it regular troponin? For our listeners in many different hospitals across the world, what would you suggest? Dr. Nicholas Mills: The evidence that has that merged very rapidly over the last few weeks and months suggests that our range of cardiac markers have very, very high prediction for poor outcome. Whether that's predicting a patient that might deteriorate and require admission to an intensive care unit for ventilation, or develop complications such as acute kidney injury or death. Dr. Nicholas Mills: There are a number of biomarkers that look very useful for predicting the course of a patient. The strongest, in most studies, is cardiac troponin. I think it's because we do have such sensitive assays now. High sensitive assays are such a fabulous way of getting a barometer of your heart health. The heart of course, is a fairly fundamental organ. If this condition is going to affect to any other organ out with the lungs. If it's the heart, you're going to be in trouble. I think high sensitive troponins, in particular, give us such exquisite information about the systemic complications of this virus that they are perhaps above all other markers, the most useful for predicting outcomes. Now, that clinical question goes beyond that. We need to understand how this virus is affecting the heart and whether we can intervene in any shape or form in response to these results in order to try and improve the course for these patients. That is a more challenging question. Dr. Greg Hundley: Nick, you've got a wonderful figure and we just heard from Leslie Cooper about the different cardiovascular disorders. Once we have elevation or experience, we see elevation in a patient with a biomarker, whether that be high sensitivity, proponent, BNP, et cetera. How does that point us in a direction of where our next move is, clinically, to combat this disease process in patients? Dr. Nicholas Mills: I think the first thing to say is that biomarkers do need to be interpreted in the clinical context and to understand that the pre‐test probability of having underlying structural chronic disease in your patient who presents with COVID‐19. That will very much influence your interpretation. If you think about the spectrum of conditions that you might see, and in fact, that we are seeing, there are a number that I would highlight. In particular, we know from many years of looking after patients with bacterial or viral pneumonia, that the pro inflammatory state of those conditions in patients who are vulnerable, older, and have underlying coronary heart disease is a really powerful risk factor for acute coronary syndrome and type one myocardial infarction. Dr. Nicholas Mills: Often in ventilated patients or patients who have clearly an alternative diagnosis, these important conditions, which are treatable, are overlooked. I think in considering the potential causes of myocardial injury of these patients, we should not overlook the probability that vulnerable patients have triggered acute cornea events in the context of their illness. Dr. Nicholas Mills: The other group that I think are really important are type two myocardial infarcts. They are an increasingly well‐recognized group of patients with the use of high sensitive tests in critical care units around the world. In the context of profound hypoxia or hypotension in sepsis, it gives the clinician managing the patient an idea about the vulnerability of the patient and their susceptibility and risk. I think that is also important. Dr. Nicholas Mills: Then, I think there's a separate group of conditions that are a direct consequence of the exposure to coronavirus and the clinical syndrome of COVID‐19. We are seeing case reports and have our own experience locally, of patients who develop myocarditis in this condition. I think it is rare, but it is real. When it occurs, it can be particularly severe and associated with prothrombotic complications. The other conditions that we are seeing are stress cardiomyopathies in relation to profound breathlessness, and that is not uncommon. Dr. Nicholas Mills: We are trying to systematically scan our more critically unwell patients in the intensive care unit to look for evidence of cardiomyopathy. Dr. Nicholas Mills: The final group that I would highlight is in those that are more severely unwell. Right ventricular dysfunction as a cost of either prothrombotic changes or of ARDS itself, is a really important observation that an elevated cardiac biomarker may be the first clue that that patient is developing cardiac decompensation. Although there's a range of different, important underlying conditions and the biomarker in itself cannot differentiate between these, I think recognizing that the patient is at risk of these underlying cardiac artery disease is an important first step. Dr. Carolyn Lam: Nick, really nicely explained. I'm going to read one of the lines from, I think, one of the concluding paragraphs from your paper, because it's really interesting. "Clinicians must recognize that troponin is not a test for myocardial infarction and it never was." Now, that's very interesting. I know in many ways you've explained it in what you said earlier, but could you maybe just end by hammering home what you meant there? Dr. Nicholas Mills: Myocardial infarction is a clinical diagnosis. It is not a test, one test. It's a combination of clinical features, a variety of different tests that help you arrive at that final diagnosis. Unfortunately, when troponin was introduced into clinical practice a number of years ago, as a replacement for CKMB, it became a sort of de facto. This is the test we use to differentiate people with myocardial infarction, without it, and that has become perpetuated in our clinical practice. Dr. Nicholas Mills: As the technologies move forward and we've developed really high sensitive tests that allow us to measure proponent accurately in almost all patients, it's become abundantly clear that it is a marker of heart injury in a very wide range of clinical conditions. We need to almost unlearn that original teaching, but this was a marker used exclusively to rule in and rule out myocardial infarction and embrace it as a test that tells us about your heart health and how it is affected in a wide range of conditions. Dr. Nicholas Mills: For me, it's never really been high sensitivity troponin in any way, a test exclusively of myocardial infarction. I use it very widely. I always find it informative in the clinical setting in order to guide decisions that I make for my patients. In a patient with ischemic chest pain and an elevated troponin, the default is, this is a type one myocardial infarction until proven otherwise. In all other settings, this is evidence of acute myocardial injury. Some careful consideration is required to determine what the mechanism is that underpins that. Dr. Carolyn Lam: There, you heard it, ladies and gentlemen. That kind of wisdom is going to last beyond COVID‐19. Thank you so much, Nick, for joining us today. That was awesome. Dr. Nicholas Mills: Pleasure. Dr. Greg Hundley: Well, listeners, now we're going to switch and talk a little bit about pulmonary emboli and to introduce that topic. We have Dr. Sophie Susan from Lille, France, who has performed a study in France, looking for this disorder. Dr. Greg Hundley: Welcome Sophie. I was wondering, could you start us off, tell us a little bit about the background for your study, the hypothesis and the question you were going to address, and then what was the study population and some of your results? Dr. Sophie Susan: I work in Lille University Hospital, which is in the North of France. During the early days of March, we had the first patients with COVID‐19 and we were very surprised. High number of patients with sudden aggravation of the respiratory symptoms. We were suspecting high numbers of, I would rather say pulmonary thrombi or pulmonary embolisms. We looked back to medical records of patients admitted in our institution last year, in the same period of time, to look at the frequency of these pulmonary embolism or pulmonary thrombi. We also looked at all the patients admitted for influenza, ARDS in our institution last year. Dr. Sophie Susan: What we observed is that there was a higher frequency of pulmonary embolism during COVID‐19. We observed 22 patients. At the moment we sent the [Research] Letter to Circulation. That means 20% of patients admitted in ICU. And by comparison, there were only 6% of patients in the same period of time in ICU last year. To be sure to avoid any bias in the data collection, we looked also at the CTPA, the angiograms, of the angiography of those patients. We observed that in influenza patients, they were much more investigation with CTPA than in COVID‐19 patients. Despite this higher number of CTPA perform, they were less pulmonary embolism or thrombi identified. Our conclusion was at that moment, that there was an awareness on the new increase frequency in thrombotic pulmonary complications in COVID‐19 patients. Dr. Greg Hundley: Thank you so much, Sophie. You've got a beautiful table in your article. Were there any particular patient characteristics that you could identify in this patient population that you think may make patients predisposed to this? Dr. Sophie Susan: Yes, we were very surprised in my region. My area is a metabolic area and we were very surprised to observe the high number of obese patients in our ICU. There was a publication from our group on the subject. We looked at the BMI of those patients and on our table, you can see that almost all of them were above 25, and the large majority about 30 BMI. They were also all receiving thromboprophylaxis at baseline at the entrance in ICU. Although all the patients were at least receiving 40 milligrams of Heparin, or even more, and some of them were also on their particular levels of low molecular weight or unfractionated heparin therapy. Dr. Carolyn Lam: That is a very important point that you just made, that some of these patients, or a lot of them, had background prophylaxis already. Sophie, could you end by telling us how have these results perhaps influence your management? Or what do you think are the implications? Dr. Sophie Susan: It's a difficult question. The first issue is that regarding the population admitted in ICU, we've got a lot of weight patients and there are no current guidelines adapting thromboprophylaxis to weight. The first question was that 40 milligram of heparin is good for everyone. Do we need to increase this regimen in obese patients? Dr. Sophie Susan: There was a proposal of ESC two years ago, and we adapted these proposals for COVID‐19 patients. We do believe that 40 milligrams of heparin is not enough for patients in ICU, for overweight patients in ICU. So for a BMI above 30, we think that we should increase the regimen of low molecular weight or unfractionated heparin. That's the first point. Dr. Sophie Susan: We've got also, a disease that is random, very difficult sometimes to perform CTPA, difficult, to move patients to those exams. Sometimes we've got to give a probabilistic treatment and in case of acute worsening of the respiratory status and in particular, in case of repositioning patients, when they are under high‐positive and expiratory pressure, sometimes they get sudden aggravation. We must think about probabilistic therapeutic approach with heparin on those patients. That's the two main conclusions we made for the adaptation of protocols. Dr. Carolyn Lam: Well, thank you so much, Sophie. I really am so grateful that you published this work here at Circulation. You very, very, fairly pointed out what you found. I thought that your inclusion of the control groups was really the best that we could do, and therefore your data represent the best available evidence for a very important question that we've all been asking. Are these patients at higher risk of pulmonary embolism? Dr. Carolyn Lam: Thank you so much for sharing that with us. Dr. Sophie Susan: Thank you very much for the invitation. Dr. Carolyn Lam: What an amazing series of papers that we have on COVID‐19. Guess what? These three that we talked about today are not the only ones. We really strongly encourage you to look at ahajournals.org/coronavirus where you can see many more papers published in Circulation, relevant to COVID‐19 as well as some commentary from experts on the front lines. Dr. Carolyn Lam: Thank you very much, once again, everyone for joining us today. Dr. Greg Hundley: Have a great week. Dr. Greg Hundley: This program is copyright, the American Heart Association, 2020  

On the day before the first day of her senior year of high school, while enjoying one last day of summer with a good friend, Coxsackie, N.Y. resident and St. Mary's parishioner Alison DeFrancesco was in a catastrophic car accident that put her in a coma for two years. When she awoke, she found herself permanently unable to move or speak. That was 31 years ago. Her mother, Marie, and niece Genevieve talk candidly with Fr. Scott about how the family endured such a trauma and how they have had the stamina to take care of Ali at home for all these years and about the love and courage she brings into their lives and into the world. This intensely personal interview will change you. Listen and uncover fresh strength to endure the COVID-19 Pandemic and the many other challenges you find yourself facing. Please share this generous gift from the DeFrancesco family far and wide.

We've got Amina Eastham-Hillier back on the show today. This time around Amina is talking all things Lyme disease. Amina is an experienced Lyme literate naturopath who specialises in testing and treating Lyme disease, Lyme co-infections, mould related illness and chemical sensitivities. Amina is a treasure trove of knowledge in her area's of expertise and today's chat offers a grounded and holistic approach to healing stealth infection and Lyme disease.  Mason and Amina cover: Lyme disease. Health sovereignty and the importance of taking charge of your own health. The multifaceted approach required to remedy chronic health conditions. Ticks - "the dirty needles of nature". Principals of prevention, tips and tricks you can embody to minimise exposure to Lyme and other pathogenic bacteria. Inflammation and gut health. Stealth viruses and the havoc they can wreak. Living in harmony with nature, and that includes viruses and bacteria.   Who is Amina Eastham-Hillier? Amina owns a successful multi-modality clinic in Noosa comprising of 18 practitioners. With over 15 years of Naturopathic and 25 years of Nutritional practice, Amina successfully treats chronic illnesses and complex cases. Amina is a Keynote speaker presenting to medical doctors and naturopaths at international conferences, medical documentaries, TV interviews, radio, seminars, webinars, podcasts and workshops. Author of “Lyme Natural” Amina won the award for ‘Australian Practitioner of the year’ in 2017 and is currently finalising her second book (Chronic stealth infections – Filling in the missing pieces).   Resources: Amina Website Amina Facebook Amina Instagram Lyme Natural Website   Q: How Can I Support The SuperFeast Podcast? A: Tell all your friends and family and share online! We’d also love it if you could subscribe and review this podcast on iTunes. Or  check us out on Stitcher :)! Plus  we're on Spotify! We got you covered on all bases ;P Check Out The Transcript Here:   Mason: (00:03) Hey, Amina. Thanks so much for coming back on and chatting with me.   Amina: (00:07) Oh, you're welcome, Mason. Thank you for having me.   Mason: (00:10) Always a pleasure. I think it was about two years ago that we jumped on, when we were different podcasts by then. Mason Taylor Podcast. We chatted about Lyme, we chatted about mold, mold when just got distributed out. And so everyone in the SuperFeast community has begun to become familiar with you and your awesomeness and I want to continue pointing people in your direction because I've found you always really influential. And watching your Instagram, I love watching you being a practitioner, live and breathe the lifestyle up in your retreat. I love your foraging tips and I love watching all the notes when you go to these conferences, whether it's ... I know you're going to ... What's the conference you're going to this weekend, you're presenting at?   Amina: (01:01) Oh, it's actually in September, but it's in Melbourne for metagenics and it's all on fatigue and looking at intricate details of just what's going on with people with fatigue and why are they not getting better? Looking at a lot of biotoxins and underlying viruses and lots of things. Very exciting.   Mason: (01:26) Well, I just love watching the adventures because you go along, obviously, and attend and upgrade your skills. You can just really tell you're an absolute nerd for all of this.   Amina: (01:36) I do love it.   Mason: (01:39) Yeah. I feel like ... You know, we've spoken to you a couple times. I know how deep you can get into the nuance of the body and testings, and really going after and hunting for the source of symptoms. And you work a lot with people with extremely chronic illness. Right?   Amina: (01:57) Yes, yes. I do.   Mason: (01:59) And we were just talking about the fact, as well, before how when you look down the barrel of either going through western medicine, a lot of people go down that gauntlet and then come out the other side without answers. And then coming into the, for lack of a better word, the natural treatment, going down that route. I can understand why going down the western route is often necessary, of course, but is cozy and comfy because there's this integrated nature where there's a specialist for everything and your doctor will talk to the specialist. On the surface, that's the idea. There's a big web that you know you don't have to think. You're just caught in it. But then if you look down, often, the natural route, the amount of information out there, the amount of conflicting information, of course that's in the western medicine as well but it's that non-integrated web that makes it so difficult at times and you've kind of got to stand up into your sovereignty and be your own hub.   Mason: (03:02) I know I send so many people your way when they're dealing with stealth infection or Lyme, as well, because I know ... I read that at Noosa Holistic Health ... Is that Noosa Holistic Health?   Amina: (03:14) Yep.   Mason: (03:15) Yep. And you were saying how you've really created a hub and how you ask for every single test that's ever been done through the western model or beyond in the natural world and try and create that melting pot. On that, I think it's important for people ... We're going to go into Lyme today. I think it's very relevant in this instance, but know whether we're dealing with chronic illness, whether it's stealth infection, or just a mystery. Finding someone who can create that hub and go and be the detective and be that central point, I just want to know ... obviously, you've created it. I just want to know the extent of which you put importance on that for someone. And then what do you like to see and procure in your patients for them to be able to feel like they have the capacity to start to be that melting pot, themselves, and really feel that health sovereignty while being supported by practitioners?   Amina: (04:21) Okay. So first of all, when patients come in initially, obviously I'm listening for what their main concerns are. And I have a jigsaw puzzle template by my side and it literally has about 50 odd pieces and I can squidge them all around if I need to. And this empty, blank jigsaw puzzle template, I actually start writing everything on and it becomes a full puzzle. And I think that's the main thing for the people to understand when I'm first having consultations with them is that they may come in saying, "Have I got Lyme? Is it this? Is it that? What's wrong with me?" And you can never give one person a definite answer because, the thing is, there are often so many things. So there are many pieces of a jigsaw puzzle.   Amina: (05:19) For example, someone might come in and they think that they've been bitten by ticks or they're not even sure, but they've got chronic fatigue, they've got pain. It might be just random pain, fibromyalgia-type pain or aches. It's often brain fog. Maybe a bit of sweating, maybe not, digestion problems, anxiety, all of the common symptoms that we see that aren't getting addressed with the normal medical models. And we just start putting it together. So I just go through a very comprehensive history and just putting all the pieces. So whether they have had chemical exposure, mold exposure ... I mean, this is a very broad summary of what I do. I think an answer to your question, is that ...   Mason: (06:07) Yeah, for sure. I mean, I guess I almost wanted just to make sure everyone had an insight into the depth and level that you'd want to be able to demand or go and find with a practitioner in order to qualify.   Amina: (06:21) Absolutely.   Mason: (06:22) And then what's the difference? Do you see certain ... the difference between a patient and just some qualities that other patients, you can help imbue in them in terms of not feeling overwhelmed or feeling empowered in the fact that you can transfer? The fact that you, yourself, you've got so many patients, so much stuff going on. You can't hold the constant hub for every single patient. At some point, it needs to bridge over into the patient themself, especially with long-term healing. Right? Is there ...   Amina: (06:53) Absolutely, absolutely. So what I like to do, I think it's really important, if patients want to. Not all patients want this. They do like the practitioners to take charge and they don't really want much information. But I think, these days, it's really important to take charge of your health and have it that each person really understands themself. So that's why I really encourage patients to gather all of your past medical results. It doesn't matter how long ago it was. Get as much information as you can. If you had a stool test with a naturopath 10 years ago, get it. Let's put it all together. Let's see, where did this start? Because of the patients that I'm seeing, they're often very chronic, complex patients that often have so many things going on and that's why it's very difficult for them to go to any one place and get a diagnosis.   Amina: (07:46) So it's really important for us to gather as much information as we can. And if you haven't had past tests, that's great. That gives us a clean platform to go, okay. Well, now we know what we need to do in the way of functional medicine testing as well as working with their doctor and seeing what treatments they may be getting at that time. But I just definitely, I can't express enough how I think it's important for patients to take charge of their own health in a way of just knowing what's going on, knowing what has happened in their body before they got really sick, and understanding their family history, things ... Even looking at genetics can be really helpful, knowing what their sensitivities are and their triggers, and understanding the state of their adrenals and nervous system, and understanding their gut and being mindful of, "Is my gut going good? Do I need a bit of a detox at the moment?" Or, "Do I need a detox from life? Do I need to sort of step back and go and have a rainforest walk or something?"   Amina: (08:56) So just being really mindful of all of the systems. And that's something of a naturopath that I think is really important for us to educate patients so that they know what to look out for and they know how to be their own sort of one-stop hubber and check in on themselves, as well as having the support of the professionals.   Mason: (09:16) Yeah. I just don't think it can be said enough. It's a great reminder and I just wanted to bring that up in the beginning because, at SuperFeast, we get asked so many ... every day. It's phone, email, Instagram, getting so many questions and some of them very gnarly and very deep questions. We don't consider our role to kind of play practitioner, we just don't. We continue to stand in the fact that we're doing tonic herbalism and we are standing for a particular philosophy and lineage. However, we don't like leaving everyone high and dry. And so what I feel like I consistently want to do and for the podcast and having these kinds of conversations, is continue to make distinct ... just that simple nature of ... when you say, "Become your own practitioner," I feel like that's quite loaded because I'm prone to this, then I feel the pressure, and I'm very much prone to putting pressure on myself, to have a level of understanding using similar language, that a practitioner would have in a specialised area, of myself.   Mason: (10:24) And then with that and put a couple of other things on my shoulders that I'm doing in life, it becomes overwhelming and I feel I'm kind of failing at this. I don't know how to manage my own body. I need to continue to rely on practitioners. But what you're saying, I just don't think it can be repeated enough for everyone to remember. If you just gather all that information so you know thyself, you can understand little patterns and your constitution. You get little clues and then put it into language that ... For me, it's been especially useful. Just put it into language for a lay person or just put it into language that's not charged and easy for you to then go take into your kitchen and your lifestyle because, as you said, just knowing. It can kind of seem like it just gets on repeat. And I just want to make sure everyone's listening. Reading your body and your digestion, watching the way that you're pooing, or your nervous system can tell if you can get that pattern to go, "Wow, it's time for a little bit of a walk. Right now, it's time for a little bit of practice...   Amina: (11:21) Absolutely. That's right. And it's just having that understanding. And sometimes, I find when I go through and I put all the pieces of the jigsaw puzzle together, literally, and then the person can see, "Oh, there's quite a few things going on." Not to be overwhelmed at all, but purely just we can see, look, we do need to work on all systems here because all systems are affected. And of course, I'm not saying to be their own practitioner and treat themselves. I'm very, of course, into seeing a professional practitioner that can monitor and help you with the dosages of herbs and so forth and give you the right medicine. But just, I find a lot of people will bounce around from many practitioners to practitioners, different types of practitioners and still not understand the basics of what's going on with their body. If they could see that, they might not be as overwhelmed and see, "Okay, I need some help with my adrenals," or, "I might need to do a bit of a gut detox. I'll go and see my practitioner," be it naturopath, Chinese medicine, integrated doctor or whoever. And we work together.   Mason: (12:34) Yeah. That working together, I don't think it's that rare anymore, but I don't know, sometimes it feels like it. I know that's definitely the biggest thing we get when we're like, "Look, we're really just going to have to encourage you to go and have someone onside, have a practitioner onside." And it can just seem like such a daunting task in the beginning, going and finding someone. But they're out there and if you're on the sunny coast, you know where to go.   Mason: (12:59) So I want to dive into Lyme. And I especially just wanted to make sure I had this resource for everyone in the community who is asking us questions. There's just so much that I can do in terms of saying, "You know, read." I like Stephen Buhner's work. Sending to your website. But I just wanted to speak to a couple of things that come up constantly that I feel will be useful, and especially useful for my team, hearing it from you in this context to pass on.   Mason: (13:37) For those of you that don't know Lyme disease, can you give a little elevator pitch, Amina, knowing that most people will know and there's many resources for people to get the understanding, including your website. But do you want to just give a little brief update for everyone? And especially your current understanding of Lyme infection?   Amina: (13:55) Absolutely. And I must say that my current understanding is just becoming more and more expansive as the years go by. But your traditional textbook Lyme is someone's been bitten by a tick and that tick has given the person an infection of Borrelia bacteria. And as a result, the person gets very sick. So it's a tick-born bacterial infection. That's a very simple textbook example. However, we know that there are ... Now Lyme, I think, has become a bit of an umbrella word. In Australia actually, a lot of practitioners use the term more Lyme-like illness and I think that's probably more appropriate because we don't know exactly what we're dealing with. So there's a lot of different types of Borrelia, not just Borrelia burgdorferi. There's actually a hundred strains or so.   Amina: (14:55) There's actually a lot of different types of Borrelia. We know that this Lyme-like illness is not just caused by ticks. We know there possible are other vectors. There's even been talk of mosquitoes. A study in Germany showing that mosquitoes could possibly be carrying Borrelia. I know there are possible other insects that can certainly pass on very similar co-infections, like midgies, sandflies and passing on things like mycoplasma bartonella, that co-infections that often coincide with Lyme patients.   Amina: (15:31) And we know that it can be passed on by utero. So if a woman's pregnant, she could definitely pass it on to her baby. Doesn't mean the baby's going to have the full on symptoms like the mother may have had. I certainly have seen quite a few different levels of patients. Some people have a positive Borrelia result, maybe even from a couple of different labs, and they really are okay. They're not suffering from a lot of symptoms. And I've seen people that we test and they've got negative Borrelia and it's not being picked up. Doesn't mean it's negative, but in the blood, the urine, and serum. And they've had lots of tick bites, lots of rashes.   Amina: (16:13) So it's a very broad umbrella term. But generally, I feel that now what we're dealing with when we're talking about Lyme-like illness ... the technical name is actually borreliosis because of it being from the Borellia bacteria infection. However, I think we just need to look at the facts that there are a lot of ticks and a lot of other biting vectors in Australia. We know that the ticks carry many bacteria. So rickettsia, ehrlichia, anaplasma, bartonella, which is a cat scratch disease as well. And we also know that Babesia, that's a very common infection in kangaroos and wallabies and is a similar infection to mosquito malaria.   Amina: (17:08) And recent studies just last year have come up with Australian ticks ... The one study, they had 21 viruses that they actually found in the ticks and they were actually affecting penguins down south of Australia. But in the studies, they weren't so sure if these particular viruses are going to affect humans, which is a very kind of, I think, controversial subject and could be. So the point is, the ticks are also carrying a lot of viruses. In fact, in this particular study, two of the viruses hadn't even been discovered. No one really knew what they were. So they're pretty yucky things. Hence, we call them nature's dirty needles. Ticks, they really are a bit of a problem.   Mason: (17:57) So just back to a couple of things. So you were talking about vectors, the possibility of passing on Borrelia by utero. And I think we got asked this question just after the mold podcast that we'd put out. It was one of the reasons I thought we've got to do a specific Lyme podcast, because someone was asking in terms of whether it can be sexually transmitted or via saliva.   Amina: (18:22) I'm not sure via saliva. I, from a practitioner perspective and upon conversations with many other practitioners from Australia and overseas that deal specifically with Lyme, I'd say clinically, anecdotally, yes. It can be passed on sexually, considering it is actually very similar. It's a spirochaetae bacteria that's very similar to syphilis bacteria, which is passed on sexually, of course, and very similar way of presenting within the body. Like, the initial syphilis, you'd get the canker sores and Borrelia, you may get the erythema, target-type rash. May not, as well. And then the symptoms can flare up for a couple of weeks or so and then, maybe, be a little bit dormant for a few months and flare up. That can happen with the syphilis for sure.   Amina: (19:16) So I think, yes. And why I think this is because I have seen families that we have tested the whole family and the mother might think she got it from the father for some reason. And upon testing, they all do have it. And the father or the mum says, "I've never been bitten by ticks or not to my knowledge." And then the children have it. So that has happened on a number of occasions. So I would say, yes.   Mason: (19:44) Yeah. Okay. So going back to the dirty needles of nature. Obviously, we were talking about the simplicity before with understanding patterns of your body so you can read your body and take very simple actions. And then you accumulate an incredible amount of benefits through taking ownership and responsibility. I think what's confusing, definitely has been for me, is just the simplicity of that. You get lost in just how potent that small accumulation of practicing that, what that can do for your health.   Mason: (20:20) In relation to Lyme, I think it's definitely worth something not being paranoid about, yet being extremely vigilant about, especially in the east coast of Australia, where we're at. The same as east coast of America and all these places where, obviously, you just need to be very real and not stay in your little box in your concrete jungle and be unrealistic about the fact that you live within gnarly nature and there is the possibility for many vectors to come and bite you. So in terms of just basic principles of prevention, have you got some just quick tips for people to embody into their lifestyles when they are camping or when they're foraging, as you do?   Amina: (21:07) Absolutely. I live out in ... I've got acreage. So every day, I go for a walk through the forest. And with my dog and I sometimes go through long grasses. So of course, the first thing is to make sure that you check yourself for ticks when you get home. So I recommend people wear light clothing if they can and then you can see the ticks. And whenever I've gone for a walk, which is pretty much every morning, I just strip off and just get straight in the shower and those clothes end up going in the wash. I also check my dog, as well, because my dog is running around with me and she does get quite a few ticks, but we get them quite quickly.   Amina: (21:48) So just be mindful of that. If it's a hot day and you've got a bunch of clothes, you're not sure ... because it's a lot of washing, otherwise. If you've got a bunch of clothes, you're not sure, it's a hot day, just put your clothes in a suitcase in the car. The ticks aren't going to survive in the heat of the suitcase. Or put clothes in the dryer for a few minutes. But definitely, you just need to check and be diligent about ... and just know, just check all over your body or your nooks and crannies.   Amina: (22:19) I mean, I have had quite a few tick bites and, of course, I go straight in with my herbs, my echinacea and my astragalus and garlic, anyway, because I actually am taking my regular immune herbs and vitamin C every day. So I'm keeping my body healthy. So I think it's important to just be healthy, as well, of course. It comes down to diet, all that sort of thing. I mean, that's the extreme, walking through forests and long grass. If you're just going for ... You need to get out. If you're just going in a park or something, just be mindful. There's lots of places you can go where the grass is short. Tuck your pants into your socks sort of thing and just enjoy. I think the benefits of being out in the nature and out in the fresh air is so helpful for your nervous system and immune system, anyway. At the end of the day, you have to live. So this is really important.   Mason: (23:22) And it always helps to have ... Well, I like using those tick-specific tweezers, having those around when you get the ...   Amina: (23:29) Oh, yes. For sure. Always have good tweezers and you can use things. There are some sort of ... People use citronella and sometimes even a little bit stronger that they can spray onto their clothes, but I think if you're going to brush up against a tree or something like that, that's when you're more likely going to ... if you're brushing up against plants and if you have animals, because animals will bring ticks in the house. So you take your boots off in the house and go and make sure you have a ... get in the shower and just don't be sitting around on your bed sort of thing with your clothes that you've been out in the forest with. Things like that. Just be really diligent.   Mason: (24:08) And in terms of if you do get a tick bite and you remove it, are you a fan of popping on dragon's blood? Any little myths that you want to bust around what you should be doing, topically?   Amina: (24:23) I actually use ... I've got a medicinal throat spray that's got sage and thyme and echinacea and I actually spray that on the bite.   Mason: (24:34) That's a great idea. Yeah.   Amina: (24:38) I think if you can use your herbs, topically, I think something like good-quality manuka honey is really good. But otherwise, just keep an eye on it. I mean, if you're going to get bitten by these sort of types of insects and ticks and mosquitoes, you just need to be mindful and just keep an eye on it and make sure it doesn't come up in a rash. If it does, then you take further precaution. And, yeah. There's not really anything more I would put onto a tick bite, no.   Mason: (25:10) Yeah, great. Just those little things to add to your culture. That's what people, over the years, when I ask ... I always get curious when people have all the herbs. And living in particular areas. Astragalus, for a lot of people, they're like, "Yep, in autumn." And then if I get a tick bite, comes up quite often that they ... just as you said. A little echinacea, even just getting a little bit of manuka inside of you, but they'll take a big does of astragalus, as well, if they have a tick bite.   Amina: (25:39) Absolutely.   Mason: (25:40) Just as a little precaution.   Amina: (25:41) Absolutely.   Mason: (25:42) And mushrooms, as well. I mean, you can get the shiitake, maitake, reishi's, and chaga's in and give it ... because there is going to be, at the time of consuming medicinal mushrooms and the beta-glucans they do in astragalus, as well. They're going to get into the bloodstream and you're going to see, most of the time, a direct impact on white blood cells and natural killer cells and macrophage activity. So that's the other one that always comes up.   Amina: (26:08) Absolutely. Definitely. I've been using some medicinal mushrooms in my clinic recently. So just some new formulas and I'm just finding, yeah, the benefits are really awesome. I think it's great. Anything you can do to boost your immune system up, but definitely the shiitake, ganoderma (reishi), and so forth are really definitely helpful and part of keeping the immune system as strong as possible.   Mason: (26:35) Yeah. I think we've got to make sure we stay in touch for when you really dive into the medicinal mushroom literature. It would really be good just to jump on and have a jam. Maybe at that point, that's what we can do when I get up to the sunny coast and I can come and visit you up there. Is it just called Hillier Retreat?   Amina: (26:52) Yes.   Mason: (26:52) Okay. I'm coming to visit you up at Hillier Retreat and we can go have a forage, because you've got ...   Amina: (26:56) Absolutely.   Mason: (26:57) The mushies up there are incredible, especially because obviously, being tropical, you can even find the tremella's snowflake mushrooms.   Amina: (27:06) Oh, yeah. There's so many. It's actually fascinating. Every day when I go for a walk, I find new mushrooms and it's just because we've got a lot, there's tree's fallen and it's just the perfect environment. Oh, it's just amazing.   Mason: (27:21) Can't wait. So then the other time we get a lot of questions, so probably the most for us is people writing to us and saying, "I've just been bitten by a tick," and they're not used to it. They haven't been in the shrub much and so ... But then after that, we do have a lot of people writing to us, whether it's themselves or their children, identify that it's been a tick bite, possibly, because I know that the rash or the bullseye esha is, I think ... what is it? Like, 60% of the time or something like that, that that..?   Amina: (27:52) Different statistics. I've heard anywhere between 30 and 60% of people will get a rash. And if you've been bitten on the scalp or some nook and cranny, you're not going to notice a rash. And don't forget, some of the ticks are so minute, they're nymph, the size of a pinhead, the baby ones you're not even going to notice. You wouldn't even know. You'd just rub it up with a towel and you might not be aware of having one at all.   Mason: (28:22) So just to help us consolidate our advice or if we're going to refer people to this podcast, what would be those first steps? What would you be looking out for symptomatically and what would be something that you'd go, okay, now you want to actually turn your head to that and knock it on the head?   Amina: (28:39) Okay. So if you know, yes, there's just definitely been a tick or a tick was attached, you might not know how long it's ... If it's just literally crawled on your arm and you feel it attached, just take it off and it's not likely going to have passed anything on too severe. But we don't know how quick. The bacteria has to actually be passed on through the tick's hypostome, it's little, pointy sort of appendage that sticks into you. And it needs to be really actually feeding in a proper feeding moment for the bacteria to release from its stomach. So depending on how long the tick's been on you, just get the tick off as quickly as easy as you can without squeezing the tick.   Amina: (29:27) Then, just be mindful. So you could certainly put any sort of antiseptic or a lot we just said, topically onto the bite. And then I would boost up with vitamin C. I would definitely boost up with those herbs. What to watch out for, if you do get a rash, then I would be more than likely, if you get a specific bullseye rash, I probably would recommend just go to a doctor and get a couple of weeks of Doxycycline, at least.   Amina: (29:54) If there's no rash ... Sometimes it can just be a bit red and puffy and swollen. Lymph glands swell up. It could just be a normal sort of allergy reaction to the tick because that can definitely happen. So just keep an eye on symptoms and, at this point, I would definitely be boosting up those herbs. Your anti-spirochete ones, so your astragalus, echinacea, as we said. Siberian ginseng, for example. Garlic ginger, which I would recommend you get the practitioner support with that, with the dosages.   Mason: (30:27) Would you put cat's claw in there, the uña de gato ?   Amina: (30:30) You can, but it's very difficult to get good quality cat's claw in Australia, right now.   Mason: (30:36) Yeah, you know what? I stopped stocking it because of that.   Amina: (30:40) Yeah, it's very difficult. I would love to be ... I did use it a lot, but I haven't been able to get it for a good couple of years and until I know that my quality sources that I get it from are available and I'm not really trusting any other ones. But there's plenty of other herbs. Andrographis is another beautiful one for these initial infections.   Amina: (31:02) So definitely, prevention is better than anything. So boost up on the herbs, anyway, and just be mindful. So that infection, you might not get any symptoms but, if in the next couple of weeks, two or three weeks, you do get some flu-like symptoms, I would go and get tested. As in, go and get checked with the doctor and just get checked. Things like rickettsia will come up quite quickly. You might need to wait about six weeks before the tests will actually show anything positive in those early stages, but I think that's a good cause for, if you have all of those symptoms, the rash, feeling not so good, lymph glands up, and then you get the flu-like symptoms, a bit of fever, it could be not necessarily Borrelia, it could be rickettsia, it could be a bit of babesia depending on the symptoms. So therefore, I would get onto it. Boost the natural packet treatment with your practitioner and you may need to go on antibiotics.   Amina: (32:05) I say this very open-mindedly that there is a place for the antibiotics, of course, for traditional medicine or conventional medicine. And we can work together on that. So I think if that is the case, otherwise, if it's just a case of, "I've got bitten and now I'm okay a few weeks later," you've been taking your herbs, eating well, resting, and nothing really flares up, I'd say that you're probably okay, but just be mindful of those. It's the symptoms that come up like the aching joints, the knee pains that, "Mmm, didn't have that before," and you haven't been running or anything in particular, to know that there is an ongoing infection. And it's really ... yeah.   Mason: (32:56) I assume it'll be similar symptom presentation in children?   Amina: (33:00) Yes, but children often won't explain exactly what's going on, but you'll know. I mean, a child might get fevers. You'd know that. The glands are up, maybe. And if they're young, they'd probably be crying a lot, feeling very uncomfortable, irritable, not feeding so well. The stools might be a little bit loose, showing there's systemic inflammation that's affecting the gut, as well. Rashes, doesn't have to be the bullseye. A bartonella rash can be almost like stretchmarks on the body. Any sort of rash, I think, needs to be dealt with.   Mason: (33:37) Yeah. And that was, when I got bit ... I think we've spoken about it. I mean, for some people might be new here, my interest was really spiked. And it was three years ago, and I got bitten by a tick, but it was very micro and it stayed on me for about three or four days and we just didn't catch it and we thought it was something else. And it was at that point, it had been feeding because it became engorged. And at that point, now I understand, oh, that's when you really got to watch it, when that engorgement has occurred there can be a transfer of bacteria. Got it out and then we were a few months away from having a baby and then I went down, the esha presented. "Okay," kind of kept on going. Kind of like, I don't know. I don't know if it was just because I was just so healthy and was just like, "Right, cool. I'll charge through this." And then after a few days, started getting fevery and started getting aching through the joints in my right hand, somewhat in my knees.   Mason: (34:33) I'd listened to enough of Stephen Harrod Buhner. You can't listen to him or read his books without coming across Lyme quite extensively. So I was like, "Right. I kind of know what this is." And so at that point, in came the andrographis, the high dose vitamin C's, a lot of astragalus and all that. But it went on for, I think it was seven to ten days it went on and I just continued to deteriorate in fever and just couldn't get out of bed. And then I was listening to one of Stephen Buhner's podcasts and he was just reiterating that, at that point, this is when you ... He's teaching about antibiotic resistant bacteria now, running rampant as many awesome herbalists are. Yet, he's like, "At this point, that's when doxycycline is going to be very useful for you to knock it on the head," and I was just in that position. I definitely had that solid belief that I would never be turning to anything like that for the rest of my life, but yeah. That one Monday night, I was deteriorating thinking, "Geez, we're having a baby soon."   Mason: (35:40) I'm at this point, and this is what I want to discuss with you next, I'm at this point where it's possibly able to be dealt with on a surface somewhat level, on acute or subacute level. And I obviously want to ensure that these bacterium aren't able to really dig their way into my system to cause that long-term infection. And so I did. I went Monday night to the emergency in Byron, showed them the rash because, here, they're a little bit more open minded. They were like, "Oh, yeah. We know what that is. Here's your doxycycline dose." And I know a lot of people have been turned away. However, I know a lot of doctors in emergency rooms have turned people away. So I'm not sure if you have any advice there on what they can ask for or say, but that sorted me out in 24 hours. And then I just continued to maintain that protocol of completely supporting my immune system and my nervous system for months. My whole lifestyle was that, but high, high doses of these herbs for quite a few months to get it out.   Mason: (36:44) But, yeah. I think it's nice to hear that that's the advice that's still standing, still quite nice and simple...   Amina: (36:53) Yeah, I think so because I've seen patients that, for example, they may have been bitten by a tick in California or in Germany and, straight away, they went to a doctor and they were only given maybe two or three weeks of doxycycline or similar. That's the main one, antibiotic. And even just taking it for that very short period of time did make it help their body, but they didn't end up getting a full-on chronic Lyme symptoms, have that go on for years and years. And how long you take it for is really dependent on the patient because some patients, in those acute times, may need it for quite a few months, that particular antibiotic and other antibiotics. But I think if you can just get in there as soon as possible and the herbal medicine, then you've got a really good chance.   Amina: (37:48) And we can sort the gut out later. We can deal with the side effects of the antibiotics and we can work on that. It's better to, I think, initially do that. And some people can't take antibiotics, it's as simple as that. So therefore, we have to just do the herbs. But this is in the real acute, black or white, yes, you've got it. There it is and we need to deal with that infection. I think it would be negligent to not have it treated with the antibiotics and using the herbs. So when I see patients that are ... most of the patients I see that are more chronically Lyme, then it's a different story. I do feel it's a different story than if ... It's questionable whether the antibiotics might help them at that point if they've already had it for two years, also, it's like, mm, okay, that's where I probably would go more herbal medicine, but I'd go in very gently. I don't go in with the hardcore antibacterial herbs at high doses, whereas I would with the acute Lyme.   Mason: (38:54) Yes. I mean, well that's ... Chronic Lyme seems to be, whenever I see anyone explaining the fact that we will have herxing reactions as you're removing infection from the body or busting up open biofilms, it's always Lyme disease that's used as the example. "Such as in Lyme disease..."   Amina: (39:14) Yeah, absolutely. And it's very important to ... it's almost two disease, acute tickborn infections and treating someone that has chronic Lyme that they may not have even known whether they ever had a tick bite or anything but ... they may have a positive Borrelia, they have all the symptoms and then we need to treat it. That's when it becomes a beautiful example of how naturopathy can help by putting all those pieces on the puzzle and treating that person holistically. And if you don't treat all of the systems, if you miss out treating the adrenals, they're going to stay tired. If you don't detox them properly and work on the liver, they're not going to eliminate those lipopolysaccharides, the dead bits of the outer shell proteins of the bacteria upon killing them.   Amina: (40:05) And inflammation has to be addressed at all times. The gut's got to work well every day. Every part of the body needs to be working at its best. When I talk about the jigsaw puzzle that I put together, there's so many factors then in chronic Lyme that are pieces of the puzzle then. It's not just about, yes, someone got bitten by a tick. Now we're looking at a full piece of toxins, mold, so forth, and the viruses.   Mason: (40:37) Well naturally, because your immune system and your energy levels, your hormonal cascades are going to be out of rhythm during that time if you've had months or maybe years of chronic infection, as well. Right? So naturally, just on the back of that, not to say that there was stealth infection or stuff going on beforehand. Naturally, it's going to come into a ... And it often seems like a perfect storm. I've met a lot of folks, especially around area, had long-term chronic Lyme and they're exhausted from the treatment protocol. I've never seen more of a bit of a jadedness towards how much they need to do and keep their finger on the pulse to get well, when it is extremely chronic. Do you feel like by bringing back a little bit more flow in the sense of understanding the puzzle, understanding how the holistic nature of what phase we're in of treatment and also what the consistent pieces of the puzzle, as you were saying, got adrenal liver. Of course, they're going to be primary. What's your take on managing the mental load and the emotional load of that whole treatment protocol?   Amina: (41:50) I think it's important to ... When we talked earlier about just taking charge of your health, you don't have to be knowing what to do, you just need to be understanding what's going on. And then work with someone that can put it all together. So for example, it can be quite simple. I can have someone with many, many piece of the puzzle. All those heavy metal toxins and genetic, MTHFR and pyrroles, and the mold exposure. It's all along there.   Mason: (42:29) All the trendy things to get diagnosed with at the moment.   Amina: (42:32) Yeah. All of those things. The tooth infection, the mercury fillings. It's all on there, you know?   Mason: (42:38) You know what? Maybe a bit of SIBO. I know that's pretty hot right now.   Amina: (42:41) Absolutely. SIBO. They've got adrenal depletion from stress that they've had. Usually, there's a period of time when they've had stress. So there's often many pieces of the puzzle. And then we need to sort of put it simply. And simply, I just look at the systems that need, basically, support. So diet. Diet alone can be amazing just to help the person with a personalised diet that's going to work for them. So making sure that they've got enough iron, enough vitamin B-12 for detox methylation, enough protein, amino acids for detoxification again, and neurotransmitter support for their nervous system chemicals.   Amina: (43:30) And diet, I think, is such a ... obviously, it's a really important part, but I think it can be so overwhelming in itself for people of what they should eat. "I've got histamine sensitivity and salicylates and oxalates and ..."   Mason: (43:44) Yeah. I mean ...   Amina: (43:44) It can be very overloading. So I think just bringing it down to really simple, a simple basic diet, simple vegetables, and understanding what works for that patient and what doesn't, because everyone's different. So I think that the diet is the most important thing and reducing any sort of inflammation triggers. Obviously, alcohol, coffee, the basic things that would be better to reduce or eliminate if possible. I like to use anti-inflammatory herbs to reduce inflammation because inflammation is going to make everything worse. And stress is going to make inflammation worse. So we've got to also work on the nervous system, the adrenals for the adrenal support.   Amina: (44:35) So in answer to your question of how do we put it all together, I think was what you were asking, is just looking at it and it just really needs to be simplified. Even looking at the liver and make sure the person is detoxing well. Well, you know, it's a case of how you feel when you eat. Do you feel nauseous after you take your B vitamins? That might indicate that your phase two detox pathways aren't working so well. You're not able to tolerate garlic of sulfurs or ... What's going on? Is there methylation problems? We can actually look, by understanding the symptoms, what may be going on there and offer that very basic liver support that might be just a case of having the right amino acids, proteins. Having some tumeric, some broccoli, sprouts. Making sure that maybe a bit of N-acetylcysteine might help just with ... obviously, we're trying to boost the Glutathione and make sure that the liver is doing its job. I love St. Mary's thistle for hepatoprotection and just to help the liver naturally do what it is supposed to do.   Amina: (45:38) So it's just about looking at the areas that really need the most addressing. And symptoms of things like brain fog and memory and focus, concentration. That can just be often due to inflammation. So often, just having some anti-inflammatory support. tumeric, amazing. chamomile, calendula, fennel, marshmallow, beautiful herbs that will support gut and inflammation can actually reduce those symptoms just by working on reducing the inflammatory markers.   Mason: (46:11) So a couple of things that are coming up. In previous conversations, we've honed in to certain explanations of particular issues using Classical Chinese terminology. And there's one thing I feel like, really, when I've gone down the depths of trying to understand naturopathy and that pathway and tried to ... I know for yourself, as well, I know the immense amount of success that you're having, which is incredible and I feel like, although I get the conversations from people who are in that exasperated state when it comes to not just naturopathy, but all doctors and all the different things that they're trying, and so I always try and not focus on that but really try and find out the key things that are, what's up? What's going on that lead to that exasperated state where someone can't really get on top of it? Hopefully, get through their symptoms and then get on the mend where they have that health sovereignty.   Mason: (47:14) Something about the way that you talk about all this, I was trying to figure out why I feel comfortable and why ... Dan Sipple, I don't know if you know him. He's a naturopath down south of Sydney.   Amina: (47:25) Oh, yeah. Yeah.   Mason: (47:25) Yeah. So he's a good friend of mine. Our personal naturopath, but especially working with my mum. He originally introduced your work to me and he really liked your stuff, as well. I think there's a nice bridging there. Not that you can merge systems. I definitely don't think we can merge and lay over Classical Chinese medicine with naturopathy, but there's something that flows in when you talk that you don't so much purely sit in that, "All right, what's the symptom? Bang. Here, slap this protocol on." There's a looking, and maybe correct me if I'm wrong, but there's a looking for somewhat of the pattern that's leading to the pathology with a particular person and then a desire to understand what's constitutionally going on for them, which leads to a bit more of ... And I know that's the theory a lot of the time in naturopathy and that's the theory of, now, modern, traditional Chinese medicine which has deviated from the classical nature and deals with symptoms, but I feel like theoretically what they say they're doing and what's actually happening is two different things because, and quite often, what's in the way is living it as a way of life.   Mason: (48:38) I feel like that's kind of what I feel is there's a bit more flow with the way you're talking about this and possibly why we see you getting such high success rates because there is that little bit of extra time in order to identify what that underlying pattern is, not just focusing on the shiny thing that is the symptom or the pathology.   Amina: (49:04) That's exactly right. And one thing I'd like to bring up is what I'm doing a lot of work with at the moment, are the underlying causes of why are the people not getting better, or why they ... Sorry, that's my dog out there.   Mason: (49:21) That's all good.   Amina: (49:22) Beautiful Jessie. Why people start getting better when they start working on their bacterial infections, but then other symptoms arising and it's viruses. We're just not paying enough attention to the underlying viruses. And I think this is something that I'm really doing a lot of work on and I'm ecstatically excited about because I'm realizing that, when I'm working on the viruses with the patients ... For example, someone in their jigsaw puzzle, they had Epstein Barr virus, glandular fever, when they were a teenager. And they had immunoglobulins tested. So it would come up IGG. So, yes, they had that Epstein Barr virus virus a long time ago. The IGM may not be coming up, sort of active antibodies, but they're still presenting with funny sweats and aches and pains. And this is almost like new symptoms and we know that, with borreliosis and a lot of these Lyme-like illnesses, symptoms do move and change.   Amina: (50:29) So looking at it, when you look at the person, you realize they had Epstein Barr virus, they've still got active herpes, or they had cytomegalovirus. Oh. And when we test, they actually had Ross River virus or Dengue fever comes up a lot, Barmah Forest. Coxsackie virus, which is your mouth, sort of your hand, foot, mouth disease viral thing. And what I've realized is that upon further testing ... There's a lab in Germany that, ArminLabs, that's actually looking at more detailed Epstein–Barr viruses and actually seeing that, even though a person had IGG antibodies, they're actually coming up with high levels of lytic Epstein–Barr virus within the cells. It's not the latent Epstein–Barr virus, which shows that basically the virus is now almost reactivating.   Amina: (51:25) Now, viruses are not like bacteria. They have their own DNA or RNA, but they're not like bacteria. They have their own organelles. The virus needs to get into a living cell, be it a red blood cell or a bacteria and it uses the cells organelles. So it needs to use our own cell organelles in order to replicate. So if a virus is in a system that maybe that person's not massively healthy or they have low levels of mitochondria, which is your energy powerhouses of the cell, or the cell is not very sort of full on effective at that time, the virus will just sit there and hang out until the cell is more nourished or ready. Or the virus will go and find another cell.   Amina: (52:20) Now what happens is, say the person starts dealing with their chronic Borrelia infection or their other bacteria, their gut dysbiosis or parasites, then it's like almost when the person starts getting a bit healthy, then the viruses will start replicating.   Mason: (52:38) Oh, god. It's so ...   Amina: (52:38) This is what's going on now and that's what I'm feeling is a big area. And I know that there are quite a few other, specialist practitioners that deal with chronic fatigue and retroviruses and things like that. There's a Doctor Dietrich Klinghardt in America that's looking a lot at retroviruses. And I would have to agree, because this is what I'm seeing, as well. And I think being mindful of that, we need to make sure that the person also has viral support and that we understand and the patient understands what's going on. Because otherwise, what happens is they take herbs and go, "Oh, yeah. I did this, but it made me worse." you know a full on Herxing that's not being dealt with because they're not detoxing well or ...   Mason: (53:29) Yeah, sorry to cut you off there, but it's really poignant and I feel like it brings up a position where I've sat with so many years, having essentially given people access to tonic herbs and to these medicinal mushrooms and then educating them as much as possible about appropriate ways to integrate these with intention. But then when you get these questions about, "Well, this is presenting and this is presenting, what's happening to me?" it is only so far and I feel like I like presenting five or six different options of what's possibly going on. And the nature of saying it's a detox reaction or it's a herx has, seemingly over the last few years, seemed too simplistic just to put out there. You know what I mean?   Amina: (54:22) Mm-hmm (affirmative). Yep.   Mason: (54:24) And so just hearing this, it's just further bridging for me. I never expect them to be simple answers that come forth when people get clue ... there's always a chance that a herb isn't for somebody, which is always the first that I like to put forth. And as well, also, doses being too large at a particular time.   Amina: (54:48) Absolutely, absolutely.   Mason: (54:50) So that gets presented first. And then going on to what comes down the line, which I ... and the general attitude, and I can feel it in you and I feel it as well, is, "Well, this is bloody exciting because there's something going on here." And just hearing that nature of, "I'm getting better," but then, bam, I just get another hit in the face and then I go down again to some new symptoms. That trap, that loop when you are working purely symptomatically and you're not going for that underlying pattern. Or in that sense, you haven't figured the pattern that the reason there's a backlog or a bottleneck within a person who's, because phase two detoxification isn't actually able to occur and because they gut these and actually were able to eliminate, that I feel like ...   Mason: (55:39) The word that's coming forth, which you are using in a practitioner mindset, which I feel can very easily be transferred into someone's everyday life before going and looking for solutions from one herb or looking to find the exact reason why you are reacting positively or negatively, seemingly, to a practice or a herb or whatever it is, is you can bring in these very sensible ideas of looking at what is the pattern that your body is going to need to be supported in in order to basically stop that bottleneck of symptoms from occurring? Or even the bottleneck of positive effects from a herb.   Mason: (56:21) If you take a herb, as far as I'm concerned, you don't necessarily want to be feeling waves of energizing and vitality straight away. It shows that there was maybe a little bit of a deficiency.   Amina: (56:33) Yeah.   Mason: (56:34) So that level of sensible nature, that seems like that and you kind of ... I don't know if you feel it. I know I try not to feel dismissive in this nature when I talk to people and go, "Look, back off. I want you to be really making sure that your gut, your nervous system and adrenals and liver," you hit on them before, it's where I land, as well, "are absolutely running on optimal and are optimised so that you can possibly eliminate any of the reactions from occurring in the first place." That's the ideal situation. But sorry, I just wanted to touch base on that because I feel ... I'm going to have my whole team, especially the team who I'm chatting to customers, just listen to this so we can get a bit more context of how to communicate it.   Amina: (57:23) Sorry, what were you wanting me to ...   Mason: (57:25) Nothing. I just stopped there. I didn't even ask a question. But I did interrupt you when you were in the middle of talking about what's going on, just after you were talking about the retroviruses, that I interrupted you there. But either I can go on with another question or is there any more of that? Because this is super interesting and [crosstalk 00:57:48]   Amina: (57:47) Oh, there is so much more. I think it's just something ... Our science, at the moment, we just don't know enough about the types of viruses. Like I said, the tick study that just came out last year showed that the Australian ticks have 21 viruses. There's studies showing that estimations of ... We have 320,000 mammal viruses that are present in our current world and possibly more, but that's just based on looking at different types of animal genre and looking at the types of viruses that might be specific to them. And it's an estimation, but I think it's a reality.   Amina: (58:33) And you think about a virus, a virus is the size of a pea compared to a bacteria that might be the size of a watermelon, compared to the size of a red blood cell that would be the size of one of those giant gym balls. So a virus is a tiny, micro, micro, microscopic thing, yet it can be so powerful. I think the whole looking at the retroviruses that mean that the viruses are either RNA or DNA. And the retroviruses, they start off the single-cell RNA strand virus into a cell. They can actually, as I said, use the cells organelles to replicate itself, but they can actually, change themselves to become DNA-type viruses and they actually change the DNA of the cell, because when that cell that now is full of this active virus that's changed itself, and it's now using the human cell's DNA, now when that cell replicates it actually has already some of the viral DNA or RNA within it. So it actually is changing us genetically.   Amina: (59:48) And that's actually not a bad thing because, environmentally, evolution, we need viruses. We need viruses. We need retroviruses to change us for evolution. It's normal. That's been happening for thousands of years, but it's just interesting. I think, at the moment, due to the way we are, our toxic bodies, electromagnetic radiation, all the chemicals, glyphosate that's being used. All of that stuff is actually exacerbating this growth of the retroviruses. That's the problem.   Mason: (01:00:25) Mm-hmm (affirmative). I'm really happy that you brought up the necessity there of just the fact that we are sharing an environment and we are co-evolving with a virus, because it does bring up that reminiscence of when germ theory was really rocking and we're still in the medical model trying to destroy bacteria and can conquer bacteria when bacteria is, in fact, a part of us and the origins of our cellular matrix that is our ancestors and likewise. We, to an extent, have been evolving and have the possibility of living in harmony with viral loads that'll have that mentality of going to war. Never really going to ...   Mason: (01:01:14) If that's the entirety of your mindset towards it, it's never going to allow you to get into what the Tao and what all these ancient philosophies were talking to was to start to get into unison with nature and with the elements. And that's where those basic principles can come about to ensure that you are not overexerting yourself. If you can take the years, and years, and years to not ... you need to alter your lifestyle so that you find yourself being able to come predominantly at the world, I'm really working on this myself at the moment, from a parasympathetic space and ensuring that you are getting your beautiful amount of sun exposure, walking and moving consistently, remaining hydrated, a diet that is working for your constitution and your intuition and is somewhat simple in that nature and not shrouded in dogma, then you've got those basic patterns and principles that will hopefully allow you to get back into unison with nature. And then we have our little tests and our supplements and our things that we can take to help us compensate for the way the world is going for as much as we possibly can.   Mason: (01:02:27) So that, to an extent, these bacteria, these nasty viruses, perhaps we can slightly get back into a place where we are living in harmony or able to have our own cells and immune system be able to manage them so they don't lead to chronic illness. And it always comes back to that simplicity.   Amina: (01:02:50) It is really about living in harmony. Sometimes I feel like I just want to sort of say to patients, we really need to accept the fact that everyone is going to have a lot of chronic stealth infections. We have up to two kilos of bacteria in our gut. We need bacteria to survive. [inaudible 01:03:15] bacteria beneficial and commensal and then you disbiotic when it gets out of balance. And of course, like I've mentioned, the viral role is an evolution thing. It's not something we can stop. Viruses don't all necessarily have to be bad, but if the body is not in balance, that's when the viruses will affect ... There's a lot of bacterial viral interactions that go on and I think this is what gets missed in these chronic patients. It's not just the fact that they have underlying viruses that haven't been treated. It's the fact that the viruses are now coinciding with the bacteria and actually ...   Amina: (01:03:58) For example, there's direct interactions like influenza, just your normal flu virus. When it comes into contact with, say, a staphylococcus-type bacteria, like staphylococcus aureus, for example ... and there's been studies proving this. The influenza virus, it's like a big sort of ... well, it's not, it's tiny, like a round shape and it has lots of appendages, like lots of sticky things sticking out of it, like lots of sort of protease is what they're called, like these cleavers. And the staphylococcus can actually make the viral appendages split. So therefore, say the virus has a hundred little arms coming from it, it splits them so it now has 200 appendages. So it has more ability to cling onto the cell wall that it's wanting to attack or to intrude.   Amina: (01:04:59) So the bacteria actually help the virus when it's first initiated into the body to survive. And other ones, like your herpes virus, can actually cause an immune suppression type environment that actually can lead to ... I think there's a gingivalis type bacteria that specifically, if you've got herpes and you've got that particular gingivalis bacteria within the mouth, they're actually going to work together so that the virus can actually survive a lot easier. [crosstalk 01:05:35]   Mason: (01:05:35) Mm-hmm (affirmative). So amazing. I don't know. I find that really fun. I find it really exciting. Kind of reminds me just not to be a snowflake with the fact that there are so many opportunistic organisms around us and it's not because they're bad, it's nothing evil, it's just ...   Amina: (01:05:57) They just want to survive, but we're all trying to survive. Everyone's doing the best they can, including the viruses. And at the end of the day, I think we're almost ... What I was saying I'd like to say to patients sometimes is that we almost energetically need to make these are friends and we really need to love our body. And that's where it comes down to. It's a very spiritual aspect, I know, but loving ourselves, loving our body, accepting what is and just allowing the balance to occur. Not neglecting oneself, but in the best environment you eat well, you breathe well, you sleep well, you eliminate well, you'd be outside, be mindful, be in nature, do all of those things that you can do to create optimum holistic health. And then because the viruses are going to do what they're going to do and the bacteria's going to do what they're going to do, but we create an environment that everything is in balance and in harmony and no one takes the mickey because, otherwise, they become opportunistic in that toxic environment.   Mason: (01:07:03) Yeah, it's like having a bunch of delinquent children sometimes inside, but. And I really appreciate ... We'll bring this home because I know you've got stuff to do, but I really ... having off the back of a conversation that's so practical and in reality, and shrouded in testing and understanding exactly what's going on and which organ systems need to be supported in order to come back to optimal within 3D reality. I 100% agree that, at that point where you mind feels comfortable, that you're moving and you're on top of that, then going in and reestablishing your relationship with yourself and the viral and bacterial and everything else loads that, within you, can often ... I've found it to be often one of the keys. Obviously, there's many keys along the way that will get people over a particular hump.   Mason: (01:07:53) And I feel ... I guess that's ... It especially brings up ... I have a friend who does a lot of this work in reestablishing your relationship with the entity of even wifi and 5G. And if you are just doing that and that alone and not being real about what's actually going on on a cellular level, that possibly can be wishy washy, some of us are strong enough to actually ... and I think we can agree upon that just with that reframing can reestablish a flow of Qi and self function in order to bring some protection. But most of all, what it does is it allows us to move forward without an identity that is derived by opposition. When we are opposing our bacteria and we're in opposition to viral load and opposition to this sick state that we're in, we create a massive glass ceiling in what's possible for us to go forth in our emerging identity.   Mason: (01:08:52) So I really appreciate you bringing that up. Thank you for that, Amina.   Amina: (01:08:56) You're welcome. Thank you.   Mason: (01:08:58) I think we've got a couple more. We could probably have a whole ... After you've talked in September, it might even be nice if you'd be up for coming and sharing on an even deeper level what you're discovering and excited about with these viral infections and these ...   Amina: (01:09:16) Definitely.   Mason: (01:09:17) ... retroviruses. I think, of course, it'd be really fun. And then dive into the mushrooms. And when I get up there, we'll have a deep dive and have a nerd-out on that world of mushie love.   Amina: (01:09:28) That'd be

It's Nice People, Rude Towns. This week, Hooker, Conception and the little town of Coxsackie. See acast.com/privacy for privacy and opt-out information.

On this episode of Dare to Be Human, Mary and Michael talk to Ric Orlando about being a passionate member of humanity, the fundamental tactile experience of being human, our fear of food and its potential to bridge us together, failure and learning to lose. BIO A renowned cook, restaurateur, writer and activist with a rock-and-roll pedigree, showman’s personality and proven dedication to the people, places and products of the Hudson Valley, Chef Ric Orlando has become a leading culinary spokesman and top draw for events, fundraisers and festivals in Upstate New York and across the country and the world. He’s authored We Want Clean Food long before Clean Food was a catchphrase; beat Bobby Flay and won Chopped — not once but twice; cooked with Top Chef Master Ming Tsai on Simply Ming; earned multiple ‘best of’ awards from Thrillist, Hudson Valley Magazine and Albany Times Union; owned local landmark New World Home Cooking in Woodstock and Saugerties, NY, from 1993 to 2018; and helped open Albany hotspot New World Bistro Bar in 2009. Today, in addition to serving as executive chef and management consultant for New World Bistro Bar, Chef Orlando is hosting two popular podcasts; writing his memoir; hosting cooking classes; holding spring and summer 2019 restaurant popups on the shores of the Hudson River in Coxsackie, NY; and traversing the world with guest culinary enthusiasts on international food tours while keeping fans up to date on his Instagram, Facebook, and other social media accounts.One Million String Beans Clam Bellies and ApizzaChefs as Addicts: Why Being Addicted to Work Could Be a Good Thing Follow Chef Ric on: FacebookInstagramTwitter Send us your questions, comments, episode ideas or your very own Dare to be Human stories to hello@daretobehumanpodcast.com, join the conversation on our Facebook or leave us a message at 518-212-7886! We record at The Mopco Improv Theatre in Schenectady, NY where you can come visit us sometime! Original music by Mark S. MerittLogo by Derek WalkerEdited by Mary DarcyRecorded at The Mopco Improv Theatre

Why You Should Listen: In this episode, you will learn about EliSpot testing and the various testing options available through ArminLabs in Germany. About My Guest: My guest for this episode is Dr. Armin Schwarzbach. Armin Schwarzbach, MD, PhD is a medical doctor and a specialist in laboratory medicine from the laboratory ArminLabs in Augsburg, Germany. Dr. Schwarzbach began by studying biochemistry at Hoechst AG in Frankfurt, Germany and pharmacy at the University of Mainz in Germany in 1984. In 1985 he studied medicine for 6 years at the University of Mainz and finished his MD in 1991. Dr. Schwarzbach developed the worldwide first Radioimmunoassay (RIA) for human Gastric Inhibitory Polypeptide from 1986 – 1991, getting his PhD in 1992. He is member of the Swiss Association for tick-borne diseases, the German Association of Clinical Chemistry and Laboratory Medicine, and the German Society for Medical Laboratory Specialists. He is an Advisory Board member of AONM London, England, and Board member of German Borreliosis Society, and Member and former Board Member of the International Lyme and Associated Diseases Society (ILADS) and has served as an expert on advisory committees on Lyme Disease in England, Australia, Canada, Ireland, France, and Germany. Dr. Schwarzbach is the founder and CEO of ArminLabs in Augsburg, Germany and has specialized in diagnostic tests and treatment options for patients with tick-borne diseases for over 20 years. Key Takeaways: - What is an EliSpot? - What organisms can be tested for using EliSpot technology? - How specific is the EliSpot in testing for Borrelia, Bartonella, Babesia, and other organisms? - Does the state of the immune system matter when considering EliSpot results? - Which infections are the most persistent? - Can the EliSpot be used to track progress or success of treatment? - What is Yersinia and where might it be encountered? - Can EliSpot testing be used in newborns and infants? - What role do viruses such as EBV, CMV, Coxsackie, and others play in chronic illness? - Can Mast Cell Activation Syndrome be triggered by viruses? - Why are Mycoplasma and Chlamydia so important to explore? - Why is IgA testing a promising new direction in laboratory medicine? - Is CD57 helpful clinically? - What microbes are more commonly associated with specific medical conditions? - How common are Rickettsial organisms? - What is "Post Lyme Syndrome"? Is it real? Connect With My Guest: http://arminlabs.com Interview Date: February 27, 2019 Additional Information: To learn more, visit http://BetterHealthGuy.com. Disclaimer: The content of this show is for informational purposes only and is not intended to diagnose, treat, or cure any illness or medical condition. Nothing in today's discussion is meant to serve as medical advice or as information to facilitate self-treatment. As always, please discuss any potential health-related decisions with your own personal medical authority.

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  Laura opens the show describing the attack of the Coxsackie in her house. Caitlin describes how her drive up to vacation went. We both discuss what a bummer the threenagers are sometimes. Laura hopes that she can take her family out to dinner on vacation. Give us 5 stars in Apple Podcasts if you like what you hear! Check out Hey Mama Kitchen! Promo code: PODCAST Find show notes for this episode at heymamapodcast.com/episodes/128 Follow us on Twitter @heymamapodcast, Instagram @heymamapodcast & like our Facebook page Hey Mama Podcast Tell us what your #igotthis and #idontgotthis moments are this week! Have a question or topic you’d like us to discuss? Tweet us @heymamapodcast or email us at heymamapodcast (at) gmail.com.   Music: Hanami by Fabian Measures

Coxsackie rears its ugly head (and hands and feet and mouth), Phoef the cat won’t shut the heck up, and the moms learn that when you have a baby, vacation should be called, “being a mom somewhere else.”

Hoy conversamos sobre: olor corporal y la alfalfa, cómo limpiar lentes, alepates o chinches, distancia de la Tierra a la Luna, halcón peregrino, virus Coxsackie. Facebook: www.facebook.com/oigamoslarespuesta/ Web: www.icecu.org Envíenos sus preguntas al apartado 2948-1000 San José, Costa Rica. Llámenos por teléfono (+506) 2225-5438 o 2225-5338. Envíenos un correo electrónico: icecu@icecu.org

Hoy conversamos sobre: olor corporal y la alfalfa, cómo limpiar lentes, alepates o chinches, distancia de la Tierra a la Luna, halcón peregrino, virus Coxsackie. Facebook: www.facebook.com/oigamoslarespuesta/ Web: www.icecu.org Envíenos sus preguntas al apartado 2948-1000 San José, Costa Rica. Llámenos por teléfono (+506) 2225-5438 o 2225-5338. Envíenos un correo electrónico: icecu@icecu.org

Dr Pandha speaks with ecancertv at ESMO 2016 about two trials of coxsackie virus as an immune modulator. Dr Pandha describes results from the CANON trial of virotherapy for bladder cancer, and the STORM / KEYNOTE200 trial which combined virotherapy with immune modulator pembrolizumab. He describes how viral stimulation of immune activity, further enhanced by checkpoint inhibitors, can have significant outcomes, and considers wider adoption of virotherapy to complement other treatment modalities.

April 24 - 30, 1976 Today Ken welcomes writer, comedian, raconteur, Dylan Brody to the show. Ken and Dylan discuss Dylan's wife's similarities to his father, nicknames, Thomas vs. Bob, being almost Canadian, small town upstate New York, Coxsackie, Tituba's Spell, Ken vs Kenny, birthday viewing, Dick Van Dyke, booze as medicine, I Dream of Jeanie vs. Bewitched, The Marx Brothers vs. The Three Stooges, The Ritz Brothers, Dylan's Cinema Education from his Film Professor Father, Forest Gump, how to pitch, Roseanne, Dog Police, Mid-Season pilots, replacing cast members, Ed Asner, Bob Newhart, Vaudeville on TV, joke math, mystery musical comedy, skipping Sunday, insulting Steve Martin, George Carlin, Lorenzo Music, Boston Documentaries, Spenser for Hire, Rich Little, impressionists, M*A*S*H, James Bond and Alan Alda and your blueprint for dealing with women, living in London, realizing the minds behind Marvel Comics, Touch of Evil, Beretta, Strong Kids Safe Kids, Shields and Yarnell, Welcome Back Kotter, Steve Ladesberg, Barney Miller, Hal Linden's Captain America Musical, callbacks, bad 70s joke structure, Michael Landon, Don Knotts' Bowling Ball, and the horrors of little Jimmy Osmond.

Les vamos a decir cuáles son las medidas de prevención que deben tomar con sus críos, qué hacer si ya ha habido un contagio en el colegio, etc.

Les vamos a decir cuáles son las medidas de prevención que deben tomar con sus críos, qué hacer si ya ha habido un contagio en el colegio, etc.

Les vamos a decir cuáles son las medidas de prevención que deben tomar con sus críos, qué hacer si ya ha habido un contagio en el colegio, etc.

Les vamos a decir cuáles son las medidas de prevención que deben tomar con sus críos, qué hacer si ya ha habido un contagio en el colegio, etc.

Kelly and I talked about the case as well as a local road rage incident and a high school where they removed the mirrors in the girls' bathroom so the kids wouldn't feel bad about their looks. Photo: State Police

There has been one confirmed and six suspected cases of the hand, foot and mouth disease at Ga-Sekgopo village outside Tzaneen in Limpopo. There have been several cases of the disease in Polokwane. It is caused by the Coxsakie virus and symptoms include fever, muscle pain, and sores or blisters in the mouth, feet, hands and throat. The Health department has today held an awareness campaign in the village about the disease. We spoke to Dr Anne Robertson, provincial paediatrician in Limpopo's health department about the Coxsackie virus...

Although virologists long assumed that lone viruses independently infect target cells, in the case of poliovirus and other enteroviruses, several viral particles can cluster within lipid vesicles—from which they collectively enter target cells, improving overall infectivity and yields, the NIH researchers report. Nihal Altan-Bonnet at the National Heart Lung and Blood Institute at the National Institutes of Health (NIH) in Bethesda, Md., and her collaborators focused on poliovirus, a particular type of enterovirus. This group also includes rhinovirus, Coxsackie viruses, and enterovirus 68, which is linked to a recent outbreak leading to paralysis among some infected children. In HeLa cells after replication and assembly, poliovirus congregates in clusters that are surrounded by double-membrane phosphatidylserine vesicles, ranging from 250 to 350 nm in diameter. Both rhinovirus and Coxsackie virus also form similar vesicles after infecting cells. The vesicles fuse with the plasma membrane of the host cell, and the viruses are released into the extracellular environment within this package, rather than as separate particles. Details appeared 12 February 2015 in Cell (doi:10.1016/j.cell.2015.01.032), and the research was featured in the May 2015 issue of Microbe.

This week, a few stories that should cause anyone critically thinking to see that those wearing badges aren't always operating with the best intentions. Story 1Deputy Law Enforcement Officer Indicted in SC Bicyclist's Death http://www2.wbtw.com/news/2012/dec/12/deputy-law-enforcement-officer-indicted-sc-bicycli-ar-5160153/  Story #2 Washington State Trooper Charged With Failing to Report Child Abuse Allegations Against His Father http://hosted.ap.org/dynamic/stories/W/WA_FAILURE_TO_REPORT_WAOL-?SITE=PAREA&SECTION=HOME&TEMPLATE=DEFAULT Story #3 Coxsackie police officer arrested for pointing loaded handgun at acquaintance http://saratogian.com/articles/2012/12/10/news/doc50c64756c00db817443096.txt Story #4 Calif. officers conspired to dismiss traffic ticket against woman who promised booze booty http://www.therepublic.com/view/story/6e8d1afa913b4cd18aa45f0431a6156b/CA--Officers-Convicted That's this week's Police Accountability Report brought to you by CopBlock.org. Until next week, stay safe and remember that badges don't grant extra rights.

Things went down this episode! Both Sean and Monica were here and we started with Noa's virginity. We spent the first hour discussing Dave Mustaine's recent outbursts and learning the meaning of coxsackie. In the second hour, Ben from The Dillinger Escape Plan called in from the recording studio to give us a status update on the new record. We talked about heaters and ended the show recapping previous parodies. Here is this week's all-cover playlist, curated by longtime listener Ross Gnarly of American Aftermath Deftones – Caress (Drive Like Jehu Cover) Agoraphobic Nosebleed – Alchohol Code Orange Kids – Web In Front (Archers Of Loaf) Detroit – Walking Disease (Trash Talk) Vestiges – Zombie (The Cranberries) Robocop – You Suffer Eddie Brock – Raining Blood Listen to the Metal Injection Livecast on Stitcher or on iTunes (please leave a rating/review as well). Also, make sure to follow us on Facebook, Twitter and Youtube.

A on the REAL author of Frankenstein (it's what you'd hoped--better than...), some to do with small boxes, and yes, I call it episode 116. It's not.   And Who Knew?! Who knew we'd have a run to the emergency room on Halloween night, an election that took up WAY more time than we thought, a novel that is actually progressing, various illnesses (hello Coxsackie!) and, you know, the rest of the life stuff.   Enjoy chapters 42 and 43!

Viral antibodies were tested in a cohort of 44 isletcell antibody-positive individuals age 7–19 years, and 44 of their islet cell antibody-negative age and sex-matched classmates selected from a population study of 4208 pupils who had been screened for islet cell antibodies. Anti-coxsackie B1-5 IgM responses were detected in 14 of 44 (32%) of the islet cell antibody-positive subjects and in 7 of 44 (16%) control subjects. This difference did not reach the level of statistical significance. None of the islet cell antibody-positive subjects had specific IgM antibodies to mumps, rubella, or cytomegalovirus. There was also no increase in the prevalence or the mean titres of anti-mumps-IgG or IgA and anti-cytomegalovirus-IgG in islet cell antibody-positive subjects compared to control subjects. These results do not suggest any association between islet cell antibodies, and possibly insulitis, with recent mumps, rubella or cytomegalo virus infection. Further studies are required to clarify the relationship between islet cell antibodies and coxsackie B virus infections.