Podcasts about epstein barr virus ebv

Board-Certified cardiologist, Thomas Levy, MD, JD, is known for his work with vitamin C, hydrogen peroxide, and oral toxin detox. To learn more, we have The Roadmap to Health and Optimal Treatment of Disease virtual workshops available to you online. But after more than a year of battling a recurrence of Epstein-Barr Virus (EBV), despite […]

In dieser Episode sprechen Joshua Hübner und Martin Auerswald über das Epstein-Barr-Virus (EBV) – ein weit verbreitetes Virus, das häufig unterschätzt wird und bei vielen Menschen chronische Erschöpfung, Immunschwäche und andere Symptome auslösen kann. Du erfährst, wie EBV im Körper wirkt, wie man es diagnostiziert und warum Eigenverantwortung und ein starkes Immunsystem entscheidend sind, um gesund zu bleiben. Dazu gibt es praktische Tipps zur Ernährung, Stressbewältigung und natürlichen Heilmitteln, die dir helfen, EBV unter Kontrolle zu halten.

Met behulp van water en citroen, bleekselderij-sap, heavy metal detox smoothies en heel veel meloenen, aardappelen en stukken fruit heeft ze zichzelf getransformeerd van chronisch ziek met meerdere auto-immuunziekten naar een gezonde sterk vrouw met een vol bos haar!   Hoe? Door de boeken van Anthony William (Medical Medium) te lezen EN direct toe te passen.   Medical Medium?   Ja, Medical Medium, Anthony William, is de grondlegger van de wereldwijde beweging voor bleekselderijsap.   Anthony werd geboren met het unieke vermogen om te communiceren met de Geest van Mededogen, die hem voorziet van buitengewoon geavanceerde genezende medische informatie.   Samengevat:   Heel veel fruit. Nog meer sapjes. Nog meer groene smoothies. Salades. En aardappelen.   Een focus op fris, vers en fruitig. Oftewel: koolhydraten en laag (lees optimaal) in vet en eiwit!   Daarover deze gloednieuwe super inspirerende podcast met Medical Medium Leefstijl Coach: Wynke Haanstra. Heel veel luisterplezier. Via: https://youtu.be/I9B67wPgXuM Vind je deze podcast inspirerend? Ontzettend leuk (en misschien wel noodzakelijk dit keer) als je het deelt met je vrienden, familie en op je socials! Wil jij ook een win-win-win-win? Sta jij achter dit werk en wil dat het voortzet? Via de knop doneren op de website www.jannekevandermeulen.nl/doneren kun je bijdragen. Heel veel dank voor iedere donatie die je doet! Meer weten over deze gezonde leefstijl? Leet het boek De Eiwitleugen: https://www.jannekevandermeulen.nl/product/de-eiwitleugen/    LAST BUT NOT LEAST: Binnenkort veeeeeel meer over het nieuwe boek wat ik aan het schrijven ben! Spiek hier alvast eventjes als je je nieuwsgierigheid niet kunt bedwingen: https://www.jannekevandermeulen.nl/product/pre-order-eerlijke-schoonheid/    Medische disclaimer: De informatie op het win-win dieet YouTube kanaal, jannekevandermeulen.nl of één van de andere mediaplatformen zijn uitsluitend bedoeld voor informatieve en educatieve doeleinden en niet bedoeld om een gezondheidsprobleem mee te diagnosticeren, genezen of behandelen. Raadpleeg een arts of medisch specialist voordat je zelfstandig wijzigingen aanbrengt in je huidige dieet en levensstijl. Disclaimer: De meningen, opvattingen en uitdrukkingen van gasten in de win-win podcast zijn niet per se representatief voor de opvattingen van Janneke van der Meulen, haar team, de win-win methode en/of aangesloten bedrijven of de organisaties die zij vertegenwoordigen.   Veel liefs en vrolijke groet, Janneke   DE WIN-WIN METHODE | VOOR WINNAARS | ZONDER VERLIEZERS

In dieser Episode tauchen wir tief in die Welt des **Epstein-Barr-Virus (EBV)** ein – ein Virus, das fast jeder in sich trägt, aber oft unterschätzt wird. Gemeinsam mit unserem Experten **Robert Krug**, Autor und EBV-Spezialist, klären wir die wichtigsten Fragen rund um EBV, seine **Symptome, Langzeitfolgen und mögliche Behandlungen**.

In this episode of the Bendy Bodies Podcast, Dr. Linda Bluestein sits down with Dr. David Kaufman, a specialist in complex illnesses, to discuss how infections, immune dysfunction, and connective tissue disorders intersect. They explore why many chronic illnesses are often overlooked or misdiagnosed. This includes conditions like ME/CFS (myalgic encephalomyeltiis/chronic fatigue syndrome), Long COVID, Ehlers-Danlos Syndrome (EDS), Mast Cell Activation Syndrome (MCAS), and dysautonomia, Dr. Kaufman shares insights on the role of Epstein-Barr Virus (EBV), Lyme Disease, small intestinal bacterial overgrowth (SIBO), and other infections in triggering chronic conditions. They also dive into peptides, plasmapheresis, exosomes, and mitochondrial health as potential treatment avenues. If you've struggled to get answers about complex illness, this episode is packed with groundbreaking insights and expert advice. Takeaways: Complex Illness Requires a Multi-System Approach – Chronic conditions like ME/CFS, EDS, MCAS, and dysautonomia are interconnected, requiring a holistic approach rather than isolated treatments. Infections Can Trigger or Worsen Chronic Illness – Epstein-Barr virus, Lyme disease, and other chronic infections often reactivate in immune-compromised individuals, leading to long-term symptoms. Peptides and Exosomes Show Promise – Treatments like thymosin alpha-1, BPC-157, and exosomes may help modulate immune function and promote healing. Pelvic Congestion & Blood Flow Issues Matter – Unrecognized vascular issues, like May-Thurner syndrome and pelvic congestion syndrome, can contribute to POTS and hemodynamic instability. Mitochondrial Health is Key to Recovery – Addressing mitochondrial dysfunction through targeted therapies can help reduce fatigue and improve overall health in complex illness patients. Connect with YOUR Hypermobility Specialist, Dr. Linda Bluestein, MD at https://www.hypermobilitymd.com/. Thank YOU so much for tuning in. We hope you found this episode informative, inspiring, useful, validating, and enjoyable. Join us on the next episode for YOUR time to level up your knowledge about hypermobility disorders and the people who have them. Join YOUR Bendy Bodies community at https://www.bendybodiespodcast.com/. Learn more about Human Content at http://www.human-content.com Podcast Advertising/Business Inquiries: sales@human-content.com YOUR bendy body is our highest priority! Learn about  Dr. David Kaufman Blue Sky: @kaufmanmd.bsky.social Website: https://www.centerforcomplexdiseases.com/ Podcast Link: https://www.youtube.com/channel/UCkJiyBgDrgE5xWi3_tFsXHg Keep up to date with the HypermobilityMD: YouTube: youtube.com/@bendybodiespodcast Twitter: twitter.com/BluesteinLinda LinkedIn: linkedin.com/in/hypermobilitymd Facebook: facebook.com/BendyBodiesPodcast Blog: hypermobilitymd.com/blog Part of the Human Content Podcast Network Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode of the Bendy Bodies Podcast, Dr. Linda Bluestein sits down with Dr. David Kaufman, a specialist in complex illnesses, to discuss how infections, immune dysfunction, and connective tissue disorders intersect. They explore why many chronic illnesses are often overlooked or misdiagnosed. This includes conditions like ME/CFS (myalgic encephalomyeltiis/chronic fatigue syndrome), Long COVID, Ehlers-Danlos Syndrome (EDS), Mast Cell Activation Syndrome (MCAS), and dysautonomia, Dr. Kaufman shares insights on the role of Epstein-Barr Virus (EBV), Lyme Disease, small intestinal bacterial overgrowth (SIBO), and other infections in triggering chronic conditions. They also dive into peptides, plasmapheresis, exosomes, and mitochondrial health as potential treatment avenues. If you've struggled to get answers about complex illness, this episode is packed with groundbreaking insights and expert advice. Takeaways: Complex Illness Requires a Multi-System Approach – Chronic conditions like ME/CFS, EDS, MCAS, and dysautonomia are interconnected, requiring a holistic approach rather than isolated treatments. Infections Can Trigger or Worsen Chronic Illness – Epstein-Barr virus, Lyme disease, and other chronic infections often reactivate in immune-compromised individuals, leading to long-term symptoms. Peptides and Exosomes Show Promise – Treatments like thymosin alpha-1, BPC-157, and exosomes may help modulate immune function and promote healing. Pelvic Congestion & Blood Flow Issues Matter – Unrecognized vascular issues, like May-Thurner syndrome and pelvic congestion syndrome, can contribute to POTS and hemodynamic instability. Mitochondrial Health is Key to Recovery – Addressing mitochondrial dysfunction through targeted therapies can help reduce fatigue and improve overall health in complex illness patients. Connect with YOUR Hypermobility Specialist, Dr. Linda Bluestein, MD at https://www.hypermobilitymd.com/. Thank YOU so much for tuning in. We hope you found this episode informative, inspiring, useful, validating, and enjoyable. Join us on the next episode for YOUR time to level up your knowledge about hypermobility disorders and the people who have them. Find this episode's transcript here. Join YOUR Bendy Bodies community at https://www.bendybodiespodcast.com/. Learn more about Human Content at http://www.human-content.com Podcast Advertising/Business Inquiries: sales@human-content.com YOUR bendy body is our highest priority! Learn about  Dr. David Kaufman Blue Sky: @kaufmanmd.bsky.social Website: https://www.centerforcomplexdiseases.com/ Podcast Link: https://www.youtube.com/channel/UCkJiyBgDrgE5xWi3_tFsXHg Keep up to date with the HypermobilityMD: YouTube: youtube.com/@bendybodiespodcast Twitter: twitter.com/BluesteinLinda LinkedIn: linkedin.com/in/hypermobilitymd Facebook: facebook.com/BendyBodiesPodcast Blog: hypermobilitymd.com/blog Part of the Human Content Podcast Network Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode, Marcel interviews Dr. Marianna Cortese, a senior research scientist at the Harvard T.H. Chan School of Public Health in the US. Dr. Cortese is an expert in the epidemiology of the autoimmune disease Multiple Sclerosis (MS). In 2022, she co-first-authored a landmark study revealing that infection with Epstein-Barr Virus (EBV) increases the risk of developing MS 32-fold — a breakthrough in understanding the disease's causes. She discusses the key findings, their broader implications, and the dream of one day eradicating MS. Learn more about Dr. Marianna Cortese's work at: https://hsph.harvard.edu/profile/marianna-cortese/ Remember to follow us on: Instagram: https://www.instagram.com/offspringmagazine_thepodcast LinkedIn: https://www.linkedin.com/company/offspring-magazine-the-podcast YouTube: https://youtube.com/c/MaxPlanckPhDnet For feedback, comments, or suggestions, contact us at offspring.podcasts@phdnet.mpg.de.  Check out our Offspring Blog for more content: https://www.phdnet.mpg.de/outreach/offspring-blog Intro & Outro music composed by Srinath Ramkumar: https://twitter.com/srinathramkumar Pre-Intro jingle composed by Gustavo Carrizo: https://www.instagram.com/carrizo.gus See you soon!

Last fall, I did a 7-part series on the 7 pathogens I see most often causing my client's symptoms. And within weeks of finishing that series, I got an email from someone asking if I had an episode on Epstein Barr Virus.I did not.So, to rectify the situation, today, I am tagging on part 8 of our Pathogen Series - the Epstein Barr Virus Episode.Today, I'm going to go over: What EBV isWhere EBV is in the bodyCommon Epstein Barr Virus symptoms Should you get Epstein Barr Virus testing?Why Epstein Barr Virus treatments failWhat EBV treatment to do insteadWhat you MUST consider if you think you have an Epstein Barr Virus reactivation...and SO MUCH MORE!If you think you have or know you have EBV or you have chronic symptoms that just don't go away no matter what you do, then this episode is for you.TIMESTAMPS00:00 Introduction to the Epstein Barr Virus Episode 00:27 Overview of Epstein Barr Virus and Symptoms 03:29 Understanding the Connection Between EBV and Autoimmunity 05:15 Hormonal Imbalances and Other Symptoms of EBV 10:29 Transmission and Prevalence of Epstein Barr Virus 13:48 Testing and Diagnosis of EBV 19:28 Treatment Approaches and Protocols for EBV 32:23 Conclusion and Final ThoughtsEPISODES MENTIONED:118// LIVER: The #1 Thing You Can Do to Ease Bloating and PMSListen to the Original (7) Pathogen Series:​233// H. Pylori Episode: Symptoms of H. Pylori, How to Interpret H. Pylori Test Results, and Why H. Pylori Treatments Fail​​234// The Candida Episode: Symptoms of Candida Overgrowth, How to Test for Candida, and Why the Candida Diet and Candida Cleanses Don't Work

Last fall, I did a 7-part series on the 7 pathogens I see most often causing my client's symptoms. And within weeks of finishing that series, I got an email from someone asking if I had an episode on Epstein Barr Virus.I did not.So, to rectify the situation, today, I am tagging on part 8 of our Pathogen Series - the Epstein Barr Virus Episode.Today, I'm going to go over: What EBV isWhere EBV is in the bodyCommon Epstein Barr Virus symptoms Should you get Epstein Barr Virus testing?Why Epstein Barr Virus treatments failWhat EBV treatment to do insteadWhat you MUST consider if you think you have an Epstein Barr Virus reactivation...and SO MUCH MORE!If you think you have or know you have EBV or you have chronic symptoms that just don't go away no matter what you do, then this episode is for you.TIMESTAMPS00:00 Introduction to the Epstein Barr Virus Episode 00:27 Overview of Epstein Barr Virus and Symptoms 03:29 Understanding the Connection Between EBV and Autoimmunity 05:15 Hormonal Imbalances and Other Symptoms of EBV 10:29 Transmission and Prevalence of Epstein Barr Virus 13:48 Testing and Diagnosis of EBV 19:28 Treatment Approaches and Protocols for EBV 32:23 Conclusion and Final ThoughtsEPISODES MENTIONED:118// LIVER: The #1 Thing You Can Do to Ease Bloating and PMSListen to the Original (7) Pathogen Series:​233// H. Pylori Episode: Symptoms of H. Pylori, How to Interpret H. Pylori Test Results, and Why H. Pylori Treatments Fail​​234// The Candida Episode: Symptoms of Candida Overgrowth, How to Test for Candida, and Why the Candida Diet and Candida Cleanses Don't Work

In this episode, my guest Dr Kasia Kines and I explore the Epstein-Barr virus (EBV), a common yet often misunderstood virus that affects a significant portion of the global population. Dr. Kasia Kines is an Amazon best-selling author of the Epstein-Barr Virus Solution, a Doctor of Clinical Nutrition from MUIH (Maryland University of Integrative Health), a graduate of the first doctoral functional nutrition program created by Dr. Liz Lipski, PhD and CEO of Holistic Nutrition Naturally LLC and EBV Educational Institute. Join us as we discuss how EBV is contracted, its symptoms including chronic fatigue, the various factors that can trigger its reactivation, how it can trigger endometriosis and impacts fertility. Dr Kines provide insights and actionable tips to help you manage your health in relation to EBV.   A NUMBER OF ACTIONABLE TIPS WERE DISCUSSED INCLUDING: Recognising personal stressors that may trigger EBV reactivation. Understanding the environmental factors contributing to EBV complications. Importance of proper testing for conditions like Hashimoto's thyroiditis related to EBV. EPISODE HIGHLIGHTS: Understanding Epstein-Barr Virus (EBV): Kasia explains that EBV is a herpes virus affecting 90-95% of the global population and is contracted through various means, including saliva and blood. Triggers for EBV Reactivation: Stress is identified as the primary reactivating trigger for EBV, with personal and environmental factors playing significant roles in its impact on health and fertility. Dioxins and Endometriosis: Kasia discusses how dioxins, which are implicated in endometriosis, can reactivate EBV, highlighting the importance of being aware of environmental toxins. Testing for Autoimmune Conditions: The conversation emphasises the need for proper testing for conditions like Hashimoto's thyroiditis, which often goes unrecognized in women with low thyroid symptoms. Chronic Fatigue and EBV: Kasia shares insights on the connection between chronic fatigue syndrome and EBV, noting that many individuals experience a decline in their health after an initial EBV infection. Importance of Holistic Approaches: The discussion touches on the need for a comprehensive understanding of health that includes emotional, environmental, and physiological factors affecting recovery from EBV. RESOURCES MENTIONED: Epstein-Barr Virus Solution Book: A comprehensive best-selling book by Dr Kines Recent Study on Heavy Metals in Tampons: Highlights concerning findings about contaminants in feminine hygiene products: https://publichealth.berkeley.edu/news-media/research-highlights/first-study-to-measure-toxic-metals-in-tampons-shows-arsenic-and-lead Shearston et al. (2024). Tampons as a source of exposure to metal(oids): https://doi.org/10.1016/j.envint.2024.108849  FURTHER READING: Wang et al., (2024). Evodiamine suppresses endometriosis development induced by early EBV exposure through inhibition of ERβ. Doi: 10.3389/fphar.2024.1426660. PMID: 39148548; PMCID: PMC11324466. Grabarek et al. (2023). Detection and Genotyping of Human Papillomavirus (HPV16/18), Epstein–Barr Virus (EBV), and Human Cytomegalovirus (HCMV) in Endometrial Endometroid and Ovarian Cancers. https://www.mdpi.com/2076-0817/12/3/397# >>Endo Fertility Podcast Goodie Bag

In this episode Dr. Kharrazian explores the world of chronic infections, such as Epstein-Barr Virus (EBV), Hepatitis C, Covid, and Human Cytomegalovirus (CMV), and their impact on our immune system. He explores how some pathogens hide within our bodies and reemerge when our immunity is compromised.He discusses the latest research linking these infections to autoimmune diseases and even cancer, and emphasizes the importance of enhancing our immune defenses rather than just relying on antiviral treatments. He covers a wide range of topics from the basics of virology, the dynamics of long COVID, and the sobering realities of Hepatitis C and Human Papillomavirus (HPV), to the ripple effects of viral infections on our overall health.Learn more at drknews.comFor patient-oriented courses, visit https://drknews.com/online-courses/For CE and CME practitioner courses, visit https://kharrazianinstitute.com/00:00 MHC proteins activate cells to fight infection.06:16 Long COVID factors: comorbidities, age, severity, inflammation, genetics13:50 Viral infection can trigger chronic inflammatory conditions.17:27 Long COVID linked to persistent antinuclear antibodies.22:53 Autoantibodies may form due to SARS-CoV-2 infection.27:28 Hepatitis B virus vaccine increases MS risk.33:58 Alphaviruses include herpes, 53% exhibit antibodies.39:30 Cytomegalovirus linked to autoimmune diseases, immune manipulation.45:39 Chronic Epstein Barr causes inflammation, cancer risk.52:02 Hepatitis C symptoms: diverse and system-wide impacts.57:33 High treatment costs spark global protests, denials.01:00:33 PCR measures viral load; biomarkers assess liver damage.01:06:08 Identify underlying health issues causing recurring infections.Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

Send us a textIn this episode, VJ explores the fascinating connection between viral infections and autoimmune diseases. From Type 1 Diabetes to Rheumatoid Arthritis and Systemic Lupus Erythematosus (SLE), research shows that certain viruses can trigger autoimmune responses in genetically susceptible individuals.VJ discusses three key viruses—Coxsackievirus, Epstein-Barr Virus (EBV), and Parvovirus B19—and how they may initiate chronic autoimmune conditions through a process called molecular mimicry. You'll learn about the latest research on these viral triggers, the mechanisms involved, and the potential for preventive and therapeutic approaches in the future.Key highlights:- Coxsackievirus and its role in triggering Type 1 Diabetes. Study here. - Epstein-Barr Virus (EBV) reactivation and its link to Rheumatoid Arthritis. Study here. - How Parvovirus B19 may contribute to the onset of Systemic Lupus Erythematosus (SLE). Study here. We also touch on the connection between EBV reactivation and viral exposure, explaining how immune suppression during or after infection may trigger EBV reactivation, potentially leading to post-viral symptoms.Want to join my new program, The Inflammation Reset, designed to help you tackle inflammation at its source and reclaim your health? You can learn more here.Tune in to discover how to restore balance, reduce chronic inflammation, and optimise your well-being from the inside out.If you are ready for change, download your free copy of The Autoimmunity Recovery Plan here so you can get started.Or, if you prefer working together 1-2-1 or would like to explore functional testing, you can find all my services here. Thanks for listening! You can join The Autoimmune Forum on Facebook or find me on Instagram @theautoimmunitynutritionist.

In this week's episode of The Cheeky Podcast for Moms with IBD, we welcome Dr. Kasia Kines, an internationally recognized expert on Epstein-Barr Virus (EBV) infections. Dr. Kines, with her extensive background in clinical nutrition and her role as the CEO and Founder of the EBV Global Institute, brings invaluable insights into the often-overlooked connection […]

Amyotrophic Lateral Sclerosis (ALS), Multiple Sclerosis (MS) are they one and the same? Is ALS and MS sometimes caused by caused by the Herpes Zoster Virus? Epstein Barr Virus (EBV) and Cytomeglavirus (CMV), which are forms of Herpes virus are they related. Yes these all can be cured! In this episode we will discuss all the possibilities that these life taking and life changing diseases may all be related and treatable in a safe, though unconventional way.

Amyotrophic Lateral Sclerosis (ALS), Multiple Sclerosis (MS) are they one and the same? Is ALS and MS sometimes caused by caused by the Herpes Zoster Virus? Epstein Barr Virus (EBV) and Cytomeglavirus (CMV), which are forms of Herpes virus are they related. Yes these all can be cured! In this episode we will discuss all the possibilities that these life taking and life changing diseases may all be related and treatable in a safe, though unconventional way.

Send us a Text Message.In this episode of "The Autoimmune RESET," VJ explores Stiff Person Syndrome (SPS), a rare and complex neurological disorder marked by severe muscle stiffness and spasms. With its autoimmune roots, SPS is often linked to other conditions like type 1 diabetes and vitiligo. VJ dives deep into the science behind SPS, focusing on its connection to pathogens such as Epstein-Barr Virus (EBV) and Cytomegalovirus (CMV). Learn how these infections might trigger or worsen SPS through mechanisms like molecular mimicry and bystander activation.We'll also discuss how SPS affects daily life, from the challenges of managing overstimulation and muscle control to its impact on high-profile cases like Celine Dion's career. Understand how SPS influences her ability to perform and the adjustments needed for managing symptoms while maintaining a demanding schedule.You will gain practical advice on living with SPS, including nutritional strategies, natural therapies, and stress management techniques that can help mitigate symptoms. Whether you're living with SPS, know someone who is, or are simply curious about this condition, this episode provides a thorough and compassionate overview of SPS, combining the latest research with real-world insights.Stiff Person Syndrome, SPS, autoimmune disorder, pathogens, infections, molecular mimicry, Celine Dion, Epstein-Barr Virus, Cytomegalovirus, natural therapies, overstimulation, health podcastYou can download your free copy of The Autoimmune RESET here.And you can access all of VJ's free resources here.If you would like to book a free initial consultation with VJ Hamilton, The Autoimmunity Nutritionist, to find out how nutritional therapy and functional medicine could improve your health, you can book an appointment here.Learn more about the functional medicine services at The Autoimmunity Nutritionist Clinic here.Thanks for listening! You can join The Autoimmune Forum on Facebook or find me on Instagram @theautoimmunitynutritionist.

As I have shared before, I had chickenpox as a child, and later that same virus came out of remission and became mononucleosis. After I discovered that I had a reactivation of that virus again in 2022, I became serious about learning more about Epstein Barr Virus (EBV). In January 2024, once again EBV reared […]

Research is the engine that drives the future. And participating in MS research is not only vital to improving scientists' understanding of multiple sclerosis, it's also empowering. And the really good news is that you can participate in MS research from the comfort of your own home. My guest this week is the Managing Director of the North American Research Committee on Multiple Sclerosis, Dr. Robert Fox. And we're taking a deep dive into the NARCOMS patient registry. We'll also tell you about the latest version of AlphaFold, a highly advanced artificial intelligence model designed to help scientists design new drugs and target disease more effectively. Evidence shows that the Epstein-Barr Virus (EBV) triggers MS. We're reviewing the results of a study that may help scientists better understand the relationship between EBV and MS.  The International Progressive MS Alliance upcoming webcast, Mobility Challenges in Progressive MS, takes place this Thursday, June 20th. Find out where you can register and why you won't want to miss this! And we're just 6 weeks away from Crush MS, a fundraising event in Napa Valley, California that raises money to support MS research. I'll be there, and I hope you can join me! We're sharing all the details. We have a lot to talk about! Are you ready for RealTalk MS??! This Week: The NARCOMS Patient Registry  :22 The most advanced AI on earth is focused on discovering new medications  1:40 Researchers learn that Epstein-Barr Virus re-activates and drives inflammation during an MS relapse  4:00 The Progressive MS Alliance hosts a live global webcast this Thursday, June 20th!  7:17 Crush MS is just 6 weeks away  8:39 Dr. Robert Fox takes us on a deep dive into the NARCOMS patient registry  10:08 Share this episode  26:12 Next Week: A special conversation with National MS Society President and CEO, Cyndi Zagieboylo  26:33 Have you downloaded the free RealTalk MS app?  27:17 SHARE THIS EPISODE OF REALTALK MS Just copy this link & paste it into your text or email: https://realtalkms.com/355 ADD YOUR VOICE TO THE CONVERSATION I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts! Email: jon@realtalkms.com Phone: (310) 526-2283 And don't forget to join us in the RealTalk MS Facebook group! LINKS If your podcast app doesn't allow you to click on these links, you'll find them in the show notes in the RealTalk MS app or at www.RealTalkMS.com The NARCOMS Patient Registry https://www.narcoms.org STUDY: Multiple Sclerosis Patient-Derived Spontaneous B Cells Have Distinct EBV and Host Gene Expression Profiles In Active Disease https://nature.com/articles/s41564-024-01699-6 REGISTER for the International Progressive MS Alliance Global Webcast: Mobility Challenges in Progressive MS https://msif.org/webcast-mobility Get Tickets for Crush MS https://www.crushms.org Join the RealTalk MS Facebook Group https://facebook.com/groups/realtalkms Download the RealTalk MS App for iOS Devices https://itunes.apple.com/us/app/realtalk-ms/id1436917200 Download the RealTalk MS App for Android Deviceshttps://play.google.com/store/apps/details?id=tv.wizzard.android.realtalk Give RealTalk MS a rating and review http://www.realtalkms.com/review Follow RealTalk MS on Twitter, @RealTalkMS_jon, and subscribe to our newsletter at our website, RealTalkMS.com. RealTalk MS Episode 355 Guests: Dr. Robert Fox Privacy Policy  

Immunic Inc CEO Dr Daniel Vitt joins Proactive's Stephen Gunnion with details of data from the Phase 2 CALLIPER and CALVID-1 trials of vidofludimus calcium the company will present at the Americas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS) Forum 2024 in West Palm Beach, Florida, from today. Vitt highlighted the significant potential of the drug in treating multiple sclerosis (MS), particularly in relation to Epstein-Barr Virus (EBV) reactivation. The CALLIPER study focuses on the effects of 45 milligrams of vidofludimus calcium in patients with progressive MS, emphasising the importance of progression independent of relapse activity. October's interim biomarker data, specifically neurofilament light chain (NFL), which is related to neuronal death, was mentioned as a key aspect of the first poster. This data aims to correlate NFL reduction with the likelihood of future disability outcomes in progressive MS patients. The overlap between the CALLIPER study and the Phase 2 CALVID-1 trial, outlined in the second poster, explores the role of EBV reactivation in MS and fatigue symptoms. Vidofludimus calcium's potential to prevent EBV reactivation and reduce fatigue in MS patients is a significant finding, with implications for post-COVID syndrome as well. The CALVID-1 study also examined Vidofludimus calcium's effects on fatigue in patients treated for SARS-CoV-2, revealing a positive impact. Presenting at the ACTRIMS Forum 2024, an important scientific conference for MS research, underscores the relevance and potential impact of Immunic Inc's findings in the MS and broader medical communities. #ImmunicInc #MultipleSclerosis #MSResearch #EBVReactivation #VidofludimusCalcium #ProgressiveMS #Neurology #ClinicalTrials #MedicalResearch #ActionsForum #proactiveinvestors #invest #investing #investment #investor #stockmarket #stocks #stock #stockmarketnews

A new paper published in the journal Science entitled, “Persistent complement dysregulation with signs of thromboinflammation in active Long Covid” sheds light on the causes of Long COVID. The authors begin by pointing out the current hypotheses about the causes of Long COVID, including persistent inflammation, autoimmunity, tissue damage, and viral reservoirs. In this study, researchers followed 39 healthy individuals and 113 COVID-19 patients for up to a year to identify biomarkers associated with Long COVID. At the 6-month follow-up, 40 patients still experienced Long COVID symptoms. They collected blood samples and measured over 6500 proteins to identify potential biomarkers using computational tools and experimental evaluation. In patients with Long COVID, there was an increased activation of the complement system, which is a part of the immune system that helps fight pathogens and damaged cells. This activation persists even after the acute phase of the disease. The complement system can cause damage to cell membranes, and in Long COVID patients, there is an imbalance in the formation of a complex called the terminal complement complex (TCC), also known as the membrane attack complex (MAC), which contributes to tissue damage. Long COVID patients experienced increased markers of tissue injury in their blood, along with a thromboinflammatory signature. This means that there are signs of damage to tissues and an abnormal immune response involving the activation of endothelial cells and the breakdown of red blood cells. These findings suggest that Long COVID is associated with ongoing inflammation and potential blood clotting issues. In patients with Long COVID, there are lower levels of antithrombin III, a protein that helps regulate blood clotting. This leads to increased cleavage by thrombin, which is a key factor in the formation of terminal complement complexes (TCCs). Additionally, Long COVID patients show elevated markers of platelet activation and the presence of monocyte-platelet aggregates, particularly in cases where Long COVID symptoms persist for 12 months or more. These patients also exhibit signs of antibody-mediated activation of the classical complement pathway, which is associated with increased levels of antibodies against cytomegalovirus (CMV) and Epstein-Barr virus (EBV). In this study, the researchers also used a sensitive test to measure antinuclear antibodies (ANA) in patients with Long COVID. They found that patients with Long COVID had a higher prevalence of positive ANA results compared to those without Long COVID. Positive ANA tests can indicate autoimmunity. Based on the data presented, it is suggested that Long COVID patients should undergo early cardiovascular assessment due to potential cardiovascular complications. Additionally, antiviral medications targeting SARS-CoV-2 or herpesviruses may help reduce inflammation and blood clotting in Long COVID patients. Therapies that target the terminal complement pathway could also be explored as potential treatment strategies for Long COVID and other post-infection syndromes. Long COVID Clinical Applications This paper confirms that inflammation of the blood vessels is common in Long COVID. Supporting microcirculation with herbs like ginkgo biloba, grape seed extract, and mango fruit powder can help reduce this inflammation and repair damaged blood vessels. These three herbs also are effective anti-viral agents against viruses like Epstein-Barr Virus (EBV) and Cytomegalovirus (CMV). Ginkgo biloba has been shown to help improve the symptoms of Long COVID. I use VascuSelect from Moss Nutrition which contains standardized forms of ginkgo biloba, grape seed extract, and mango fruit powder. I also use palmitoylethanolamide (PEA) combined with luteolin to reduce inflammation and fight chronic viruses. Both of these are found in PEA Luteolin Select from Moss Nutrition.

The Case:Ariella has Hashimoto's and hypothyroidism and has been struggling with her weight since her diagnosis. Everything that had worked in the past for weight management was not working.She tried very low-calorie diets but knew that it was neither sustainable or healthy.When I met Ariella, I saw how much she was struggling and I knew exactly where we needed to look to solve her health mystery. Before we review Ariella's case and introduce you to our guest expert, I know some of you have come here looking for the link to Ignite+! Here is the link: https://completenutritionandwellness.com/shop/ignite.html Be sure to use promo code IGNITE to save 10% The InvestigationI hear about the struggles of weight management from my Hashimoto's and hypothyroid clients all the time so I know how frustrating it can be because it is so much more complicated to navigate. That's why I was excited to connect with Michael Antonelli. He is a leading expert in functional nutrition and wellness, with a wealth of knowledge in the realm of thyroid health. He is also the founder of Healthgevity, a nutraceutical company. He has a passion for uncovering effective strategies for metabolic optimization so I knew he was the perfect person to discuss Ariella's case with.Why It's Hard to Lose Weight with Hypothyroidism and Hashimoto'sThe battle against weight gain with Hashimoto's extends beyond thyroid support. Slow metabolism, hormonal imbalances, water retention, fatigue – each a piece of the intricate puzzle. If you find yourself ticking off these challenges, you're not alone. Michael Antonelli sheds light on the complex web of factors, from blood sugar intricacies to the downstream effects on adrenal glands. It's not just about shedding pounds; it's about unraveling the complexities and finding personalized solutions. Understanding these nuances empowers you to reclaim control over your well-being.Navigating the Blood Sugar Balance with Hashimoto'sBalancing blood sugar is a cornerstone in our journey toward better health. I often encounter people who've heard about blood sugar but might not grasp its significance fully. It's more than just a buzzword; it's a vital component of our well-being.Michael Antonelli sheds light on the importance of maintaining blood sugar levels within a specific range. Think of it as orchestrating a symphony—timing and balance matter. For those practicing intermittent fasting or relying on small meals throughout the day, the goal is to keep glucose levels steady. This steady supply fuels our bodies optimally, ensuring they perform at their best.But what causes blood sugar spikes, and why are they problematic? Michael explains that these spikes can result from various factors, such as skipping meals or consuming high-sugar or high-carb foods without adequate protein or fat. The body responds with insulin production to lower the elevated blood sugar. While this might provide a temporary energy boost, it initiates a cascade of metabolic challenges, contributing to weight gain or resistance.What's the Difference Between Brown Fat and White Fat?Many people don't realize that there are different types of fat and that each plays a different role in weight gain and weight loss. Brown Fat: This is the active player, a metabolic powerhouse buzzing with mitochondria. Think of it as the body's go-to for sustainable energy. Activating brown fat is so much more than weight loss as it influences everything from clarity of thought to overall vitality.White Fat: On the flip side, we have white fat—a storage unit designed for emergencies. The challenge with white fat is convincing the body to part ways with this resilient fat. White fat is what we are targeting with weight-loss practices like cold exposure, intermittent fasting, exercise, and calorie restriction. What we're really doing is trying to awaken the elusive brown fat and restore metabolic equilibrium.In short, brown fat is the energetic performer, which contrasts sharply with the emergency reserves of white fat. We can reprogram the body's response system through movement and diet so that it releases excess fat stores, paving the way for a harmonious equilibrium. Understanding and managing the two types of fat isn't just about weight loss, it provides a more holistic way to reclaim mental clarity, reduce fatigue, and even improve our mood. Understanding Insulin Resistance in Hashimoto'sInsulin resistance is a term that a lot of people use without a clear understanding. What's important for people with Hashimoto's and hypothyroidism to note is that they can be susceptible to insulin resistance. In this episode, Micheal and I get back to the basics and look at the impact it has on those with hypothyroidism. Insulin's Role: Insulin, the blood sugar maestro, orchestrates glucose entry into cells. However, in conditions like clinical hypothyroidism, this harmony falters. Reduced sensitivity to insulin results in elevated blood sugar, paving the way for weight gain and metabolic challenges.The Hypothyroid Connection: Literature suggests a strong link between hypothyroidism and insulin resistance. Understanding this connection is pivotal. Hypothyroidism hampers insulin's effectiveness, creating a domino effect that extends beyond mere blood sugar regulation.Metabolic Health: It's not just about insulin; it's a symphony of hormones—leptin, ghrelin, adiponectin—each playing a crucial role in metabolic health. Navigating these intricacies is key to unlocking the secrets of optimal well-being.When most people think about insulin resistance, they go to the standard advice of "just avoid carbs". It's not that simple. Michael and I break down this common recommendation, exploring the nuances and offering a more comprehensive perspective on managing insulin resistance. It's time to empower ourselves with knowledge and embrace holistic solutions for lasting well-being.Demystifying Leptin and GhrelinLeptin and ghrelin are hormones that often hold the key to weight management because they control appetite and satiety. Leptin, produced by fat cells, regulates weight, energy, and even influences insulin sensitivity. Balancing leptin levels is crucial for metabolic and reproductive health (especially for those navigating fertility challenges with hypothyroidism).Ghrelin, another player in appetite and energy balance, influences growth hormone release, fat storage, and stress response. Lifestyle choices can have a big impact on these hormones. Opt for a high-fiber, low-glycemic diet, balance healthy carbohydrates and fats, and consider small, frequent meals. Exercise is also key as it contributes to hormonal harmony. Supplements play a role and when combined with exercise and healthy eating, they form a powerful approach to help you reach and maintain your health goals.Revolutionizing Wellness with Peptides for Leptin and Ghrelin HarmonyIn the world of nutrients, peptides emerge as potent influencers for critical hormones like leptin and ghrelin. Peptides (small amino acid chains) activate cells, giving them a pivotal role in activating the leptin and ghrelin hormones.The DNF-10 peptide matrix exhibits impressive effects on ghrelin and leptin. Short-term use modulates ghrelin, while prolonged application improves leptin levels, aiding appetite control and encouraging healthier food choices.Michael shared that in one study, a daily 500-milligram dose led participants to consume 600 fewer calories daily over eight weeks. He used the analogy of these peptides acting like a Roomba vacuum cleaner, addressing specific needs without unnecessary intervention. They jumpstart positive changes, fostering better food choices, and increased energy levels.Peptides offer a short-term, high-impact approach, but also move people toward healthier habits and sustained well-being. The aim is not prolonged reliance but to instill confidence in the body's optimal function through improved lifestyle choices.Weight Loss Through AMPK and Metabolic SupportI know that when most people think about weight loss, they're focused on that number on the scale. But it's important to look at the big picture and also consider fat loss. Specifically, targeting stubborn white fat and distinguishing it from essential muscle and water weight. One pivotal player in this process is AMPK, or AMP-activated protein kinase.AMPK is an enzyme that helps with energy  utilization and metabolic regulation. It aids in glucose regulation, lipid metabolism, and protein synthesis, promoting energy homeostasis. Activating more AMPK becomes a key way to enhance longevity and overall health.There are herbal and nutrient supports that boost the effectiveness of AMPK. Bitter melon, particularly the trademarked Factor 21, stands out for its ability to regulate fibroblast growth factor 21 and activate AMPK. Additionally, compounds like Actiponin and INU-slim further contribute to appetite regulation, calorie balance, and glucose control.Another potential addition to the arsenal is L-BAIBA, a metabolite of L-Valine which is typically produced during intense workouts. Acting as an exercise mimicker,  L-BAIBA enhances the positive effects of exercise, facilitating white fat reduction and increasing thermogenesis. Michael explained that synergizing these elements in proper therapeutic doses creates a powerful combination, offering a comprehensive approach to sustainable weight management.Blood Sugar Support: The Dihydroberberine AdvantageBerberine, once famed for its gastrointestinal (GI) health benefits, has become a standout in blood sugar regulation. However, its efficacy often comes at the cost of GI upset due to the conversion to dihydroberberine in the gut. This led to the exploration of dihydroberberine as a more potent and gut-friendly alternative.Michael shared how dihydroberine proves superior on multiple fronts. It boasts five times greater absorption and twice the half-life compared to standard berberine. This means longer-lasting effects without the need for higher doses, sparing individuals from potential GI discomfort. He says the ideal dose of dihydroberberine falls between 100 to 300 milligrams, with 200 milligrams emerging as an effective sweet spot.Choosing dihydroberberine over traditional berberine not only ensures better absorption but also sidesteps common issues associated with GI complications. This makes it worth consideration for those seeking optimal blood sugar support without compromising digestive comfort.What I Recommend for Weight Loss with Hashimoto'sNavigating a sea of supplements can be overwhelming, often leading to compliance challenges. Recognizing this, I'm always looking for solutions that are simple, easy to stick to, and effective for those with Hashimoto's and/or hypothyroidism. I found that Ignite+ is a comprehensive solution that combines all of the ingredients we talk about in this episode, in precise dosages for optimal metabolic support. Plus, if you know me then you know I'm all about the scientific proof and this product has done the research, addressing body composition, blood glucose levels, insulin resistance, ghrelin, leptin, AMPK activation, and thermogenesis.Now, I'm personally using it and many of my clients have also gotten good results but you need to consult with your doctor to determine if this is the right option for you. If you decide to give it a try, you can enhance your experience by paying attention to your body's signals. Whether you're aiming to reduce cravings, increase energy, or stabilize glucose levels, listen to what your body tells you. Experiment with dosages and consider the timing based on your health goals.Holistic Approach to Weight ManagementNavigating weight management with thyroid conditions requires a nuanced approach. In our conversation, we touched upon the challenges of fatigue and anxiety, common concerns for those with hypothyroidism and Hashimoto's. Whether aiming to shed a few pounds or embark on a larger transformation, Ignite's synergistic blend offers a holistic solution. But remember, it's not just about the weight you lose; it's about supporting your body's metabolic health for sustained well-being. Remember, consult with your healthcare provider before introducing any new regimen.If you decide that Ignite is right for you, use this link:ttps://completenutritionandwellness.com/shop/ignite.htmlBe sure to use promo code IGNITE to save 10% Mystery SolvedFor Ariella, we needed to take a holistic approach to support her body's ability to burn fat and lose weight as well as enhance her metabolic markers and overall well-being. I knew that the first place to start was to support her for her thyroid type. To determine that, I ran detailed blood work. She was the unavailable thyroid type which meant that she had enough thyroid hormones but her body wasn't able to properly use it. Next, we looked at her Hashimoto's triggers and discovered that several had not been addressed. We needed to calm her immune system down to stop the attack on the thyroid. Through her bloodwork, we also discovered she had Epstein Barr Virus (EBV), Helicobacter pylori (H. pylori), and some overgrowth of Candida in her gut. Next Steps Recognizing that results would take time, I wanted Ariella to experience immediate benefits. Introducing dietary changes for effective fat burning, I incorporated the Ignite+ supplement, as discussed with Michael. Unlike quick fixes or diet pills, Ignite stands out by balancing various metabolic pathways, fostering genuine weight loss, and curbing cravings.Happy EndingWithin days, Ariella noticed a significant reduction in cravings and enhanced satiety after meals. This positive shift allowed her to adhere easily to the plan. The energy boost from Ignite propelled her workouts, leading to weight loss rather than gain. She lost 10 pounds within a month. We plan to continue with Ignite for 3-4 months alongside ongoing support for her Hashimoto's triggers, aiming to reach her goal weight by shedding the remaining 25 pounds.Eliminating Health MysteriesFor Ariella, we were able to find that missing piece of the health puzzle and help her regain her health. Could this be the missing clue for you or someone in your life? Links:Resources mentionedThanks to my guest Michael Antonelli. You can connect with him through his website or on Instagram.  Suggested ProductsIgniteRelated Podcast Episodes:111 What Is Your Thyroid Type? (and How to Manage It)43 Everything You Need to Know to Interpret Epstein Barr (EBV) Results101 5 Reasons You're Not Losing Weight58 Underlying Causes of Recurring Candida w/ Dr. Michael Biamonte33 The Case of Candida, The Great Mimicker w/ Dr. Michael BiamonteThanks for ListeningIf you like what you heard, please rate and review this podcast. Every piece of feedback not only helps me create better shows, it helps more people find this important information.Never miss an episode -  Subscribe NOW to Health Mysteries Solved with host, Inna Topiler on Apple Podcasts, Spotify, Stitcher or Google Podcasts and remember to rate and review the show!Find out more at http://healthmysteriessolved.comPLEASE NOTEAll information, content, and material on this podcast is for informational purposes only and is not intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified physician or healthcare provider.Some of the links provided are affiliate links. This means we may make a very small amount of money should you choose to buy after clicking on them. This will in no way affect the price of the product but it helps us a tiny bit in covering our expenses. 

Introduction: Ryan Courneya is a Lyme disease advocate who delved deep into the intricacies of this illness for years after getting sick and now wishes to share his discoveries and experiences with others. Ryan's Initial Experience with Lyme: Ryan didn't perceive ticks as dangerous, but hindsight reveals their threat. Endured stress from an intense lifestyle, leaning on exercise and supplements for relief. Pursued a career in marketing at Sanford Health, later transitioning through various sales positions. Began to notice health symptoms intensifying, wondering if they were linked to factors like caffeine intake. Medical Journey: Consulted primary care for routine evaluations. Misdiagnosed with occipital neuralgia and sudden onset depression and anxiety, but his health issues persisted. Felt that numerous doctors disregarded his symptoms. A friend proposed that his health issues might stem from Lyme, an idea that was both alarming and affirming for Ryan. Treatment and Recovery: Tested and found positive for European and American strains of Borrelia Burgdorferi, as well as Babesia Microti, Cytomegalovirus (CMV), Parvovirus, and Epstein-Barr Virus (EBV). Leveraged IV Ozone Therapy with an Ultraviolet (UV) component to combat Lyme bacteria. Incorporated the WAVE1 device by FREmedica, a frequency therapy instrument. Used herbal supplements, particularly Doctor Bill Rawls' Lyme protocol grounded in Stephen Buhner's research. Advocated for a proactive mindset as pivotal in the healing journey. Further Exploration and Treatment: Addressed potential mold concerns and explored methodologies for testing both his physique and residence for mold. Investigated treatments tailored for related viruses. Experimented with methylene blue, deducing it's most effective when combined with red light therapy. Underwent SOT Therapy, a method crafted to pinpoint and exterminate specific pathogens. In Ryan's case, it was directed at Borrelia Burgdorferi, the Lyme-inducing bacterium. Conclusion: Ryan emphasizes that while it's beneficial to reduce and manage pathogens, one doesn't need to eradicate all of them to maintain good health. He notes that certain microbes, like EBV, might remain but can coexist with a strong immune system in a balanced state. Stresses the significance of understanding one's life purpose in confronting chronic diseases. Ryan continues to assist others by recounting his journey. For a deeper insight into Ryan Courneya's healing trajectory and the therapeutic methods he embraced, tune into the complete episode on our website or any primary podcast platform.

In this episode, Robin Riddle, FNP-C goes over the symptoms of acute infections of Epstein-Barr Virus (EBV), how to test for it, and what to do for treatment! What did you think of this episode of the podcast? Let us know by leaving a review! Connect with Performance Medicine! Sign up for our weekly newsletter: ⁠⁠⁠⁠⁠https://performancemedicine.net/doctors-note-sign-up/⁠⁠⁠⁠⁠ Facebook: ⁠⁠⁠⁠⁠@PMedicine⁠⁠⁠⁠⁠ Instagram: ⁠⁠⁠⁠⁠@PerformancemedicineTN⁠⁠⁠⁠⁠ YouTube: ⁠⁠⁠⁠⁠Performance Medicine⁠⁠⁠⁠⁠

Today we are going to cover the topic of Chronic Epstein-Barr Virus (EBV) with Dr. Christopher Bump. Dr. Bump is a functional medicine practitioner with over 35 years of experience in clinical nutrition. His practice philosophy includes integrating science-based alternative and integrative therapeutics, applied with a systems biology approach. Today, we'll uncover the mysteries surrounding chronic EBV infections, discuss the potential long-term effects on health, and explore effective strategies for diagnosis, and treatment using functional and integrative medicine. So join us for this enlightening conversation that will provide valuable insights for those affected by chronic EBV and give you steps to take to elevate your health and wellness. We hope you enjoy!

If you have been given a confusing autoimmune diagnosis and have been told that your body is attacking itself, you may already feel disempowered and hopeless. I am here to share with you the tools that have personally helped me overcome Hashimoto Thyroiditis and  to burst that bubble. Your body is NOT attacking itself.  It never attacks itself. This is a misguided theory. Our body is not attacking itself, but it is attacking a virus called Epstein-Barr Virus (EBV) that is creating the symptoms you are experiencing. Your body is fighting for you, not against you, now and always!Tune in to Noa's 20 mins solo episode and make sure to take notes, it can change your life!Sign up to Noa's NEW 360 Wellness course and receive a 15% coupon code when you mention Raising the New Earth Podcast! Click the link here: https://naturallynoa.com/coursesWe thrive in community - and we'd love you to be part of ours!Join the conversation @raisingthenewearth on IG , YouTube- or all other podcast platforms and learn more at www.raisingthenewearth.comDISCLAIMER: By watching/listening to this post including but not limited to video, text, reel, audio, (“Post”) you understand and agree to the following: This Post is for General information purposes ONLY. We are not liable for any loss, death, property damage, or bodily injury, based on your use or interpretation of the information in this Post. This Post should not be construed as a promise of benefits, a claim of cures, or a guarantee of results to be achieved.

Let's break down Espstein Barr virus in today's episode…

Today I want to explain five things you need to know about the Epstein-Barr virus (EBV). Roughly 95 percent of the population has the Epstein-Barr virus. The more you know about EBV, the less you'll be adversely affected by it. The Epstein-Barr virus can use different strategies to go under the radar and survive in a person's body. The virus can go dormant and become very difficult for the body to detect. You can never get rid of EBV—you have to focus on keeping it in remission. To keep it in remission, you need to understand the strategies of the virus and how to support the immune system to keep it under control. Important things to know about the Epstein-Barr virus: 1. You can't get rid of it 2. It's associated with an increased risk of certain cancers, autoimmune diseases, rheumatoid arthritis, chronic fatigue syndrome, and fibromyalgia 3. It blocks key immune nutrients that your cells depend on, like vitamin D, vitamin A, and zinc 4. It modulates fever response 5. Emotional stress may trigger EBV to come out of remission Three things to help inhibit EBV from coming out of remission: 1. Decrease your stress and exposure to triggers 2. Take cod liver oil 3. Choose one or two of these herbs: • Elderberry • Echinacea • Olive leaf extract • Andrographis • Astragalus

The Case:  Mia has been dealing with Hashimoto's and hypothyroidism for over 2 decades. Her Hashimoto's wasn't diagnosed until 15 years after her hypothyroidism diagnosis. She's done a great job regaining her health but recently hit a plateau and started to regress.   In my years of clinical practice, I've encountered countless cases like Mia's. Despite her Hashimoto's going undetected for such a long time, she had a remarkable journey to better health. She eliminated gluten and dairy from her diet, optimized her medication, and delved into understanding her Hashimoto's triggers. She also addressed Epstein-Barr Virus (EBV), gut health, and heavy metal detoxification. She even attended retreats focused on limiting beliefs and trauma release. Despite her efforts, Mia saw her symptoms return including fatigue, weight gain, hair loss, and brain fog, along with rising antibody levels. She hadn't changed her routine, so she sought my guidance to uncover the missing pieces of her health puzzle. The Multifaceted Approach to Thyroid Health Having worked with numerous thyroid cases over the past two decades, I've learned that supporting thyroid health requires a multifaceted approach. While biochemistry is crucial, it's not the only piece of the puzzle. Mia had already made significant strides in this aspect, but there was more to explore. Just as you can't eliminate every bacterium during a gut cleanse, we can't address every trigger. Instead, we must focus on what we can, allowing the body to take care of the rest. Our bodies possess remarkable healing capabilities, but they need the right environment to flourish. Often, our bodies are in a constant state of stress, preventing them from healing naturally. This is why I firmly believe that alongside biochemistry, we must consider our emotions, beliefs, past traumas, thoughts, and even our connection to something greater than ourselves. Daily Integration of Mind-Body Practices Mia understood the importance of the mind-body connection and had engaged in programs to address it. However, she, like many, struggled to maintain lasting results without daily integration. I shared a similar experience with a belief workshop I attended. Although I felt lighter and different immediately after the workshop, I didn't consistently practice the techniques provided. Over time, the benefits waned, and doubts resurfaced. This pattern can apply to you as well. Perhaps you've completed a course or retreat but struggle to apply what you've learned daily. It's easy to get triggered by everyday stressors, from traffic jams to unexpected delays. While activities like meditation and yoga classes help, they often serve as reactive measures. What if we could proactively maintain a state of balance and relation instead of reacting to stress? Nervous System Regulation for Enhanced Immunity Maintaining a balanced state enables us to regulate our nervous system. When our nervous system is in check, our immune system functions optimally, even addressing triggers we may have missed. The body possesses innate healing abilities; we just need to get out of our own way. If you're thinking, "I'm already so busy with life," remember that it's not about doing more; it's about working smarter. By integrating daily practices that enhance our ability to relate rather than react, we can profoundly impact our thyroid health, immune system, overall well-being, and mood. Five Practices to Lower Stress and Enhance Thyroid Health In this episode, I go into greater detail on the 5 things that you can do right now to decrease reactivity and deepen your body connection. These practices can have profound effects on your thyroid, and immune system health, as well as your overall mood and general health.   Use Your Imagination Positively: Focus on what you want rather than what you don't want. Your thoughts have a profound impact on your body, so be mindful of negativity.   Choose Your Language Wisely: Shift from "have to" and "need to" to "choose to" and "want to." This change in perspective can reduce stress.   Start Your Day Positively: Pay attention to your first thoughts upon waking. If they're negative, redirect them toward a positive outlook for the day.   Practice Mindfulness: Keep a part of your attention on a specific body sensation throughout the day. This keeps you present and less reactive to stressors.   Express Yourself: Repressed emotions and an inability to communicate can negatively affect your thyroid. Begin by acknowledging what you wish to express, even if it's in writing, and work towards open communication.   Mia's Case Study in Turning Her Hashimoto's Around Mia and I focused on integrating these practices into her daily life. While the techniques are powerful, they're not time-consuming and can be seamlessly woven into your routine. The results were astounding. In just two months, Mia transitioned from feeling isolated and exhausted to meeting an amazing person, relocating to a better place, securing a higher-paying job, and experiencing increased energy. Her thyroid antibodies decreased significantly, and her T3 levels improved. It was remarkable how quickly and powerfully these changes occurred. If you resonate with Mia's story, know that there are ways to become aware of and address daily challenges. I'll be hosting a workshop on this topic to help you clear anything that hinders your thyroid health and immune system. The process is easier than you might think. Please reach out to me on Instagram (@innatopiler) for more information. Your Health Answers Are Within Reach No matter what health issue you're facing, remember that solutions exist. Sometimes they align with your expectations, while other times, they take a different path. Regardless, don't give up. Your body has incredible potential, and by exploring different angles and daily practices, you can unlock your full health potential. Eliminating Health Mysteries For Mia, we were able to find that missing piece of the health puzzle and help her regain her health. Could this be the missing clue for you or someone in your life?    Related Podcast Episodes: 5 Ways to Downregulate the Nervous System and Heal Faster 4 Ways to Calm the Immune System and Support Hashimoto's How to Support your Thyroid and Immune System Through Authenticity   Thanks for Listening If you like what you heard, please rate and review this podcast. Every piece of feedback not only helps me create better shows, it helps more people find this important information. Never miss an episode -  Subscribe NOW to Health Mysteries Solved with host, Inna Topiler on Apple Podcasts, Spotify, Stitcher or Google Podcasts and remember to rate and review the show! Find out more at http://healthmysteriessolved.com   PLEASE NOTE All information, content, and material on this podcast is for informational purposes only and is not intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified physician or healthcare provider. Some of the links provided are affiliate links. This means we may make a very small amount of money should you choose to buy after clicking on them. This will in no way affect the price of the product but it helps us a tiny bit in covering our expenses.   

Intro: In this episode, we welcome Dr. Ashley Beckman, a health and wellness authority with a unique focus on individualized care. She discusses her background, her family's entrepreneurial spirit, and how it played a significant role in shaping her perspective on health and wellness. Entrepreneurial Background: Dr. Beckman speaks about her family's background in entrepreneurship and how it influenced her perspective on health care. She delves into the need for a for-profit model in health care and the potential for it to deliver the highest level of service. Individualized Care: Discussing the complexity of Lyme disease and the high costs associated with individualized care, Dr. Beckman offers an interesting take on why Lyme disease treatments can be so expensive. She also sheds light on why traditional protocols may not always yield the desired results and can sometimes be damaging to the body. Personal Encounter with Lyme: Dr. Beckman shares her personal encounter with Lyme disease and how she had to apply her expertise to her situation. Her personal journey is a testament to her dedication to finding effective solutions for complex health challenges. Definition of Lyme Disease: In the realm of Lyme disease, the number of definitions can often be as varied as the number of practitioners treating it. Dr. Beckman discusses her understanding and definition of Lyme disease, stressing the need for comprehensive testing, including for other pathogens such as Epstein-Barr Virus (EBV). Emphasis on Mold Toxicity: One of the key elements in Dr. Beckman's practice is focusing on mold toxicity. She argues that sometimes the most significant health concern isn't Lyme disease, but other underlying conditions like mold toxicity, which must be addressed first. Detox Protocols: Detoxification is a central part of Dr. Beckman's practice. She discusses the importance of tailoring detox protocols to each patient, taking into account their unique needs and bodily responses. Genetic Differences: In the world of medicine and health, one size doesn't fit all. Dr. Beckman stresses the significance of genetic differences and how they affect the way individuals respond to treatments, food intake, and even detox protocols. Nutrition in Healing: Nutrition is a key player in the healing process. Dr. Beckman highlights the importance of a balanced diet and how to make healthier choices, such as reducing sugar intake and incorporating more protein into meals. Collaboration in Healthcare: Dr. Beckman advocates for a collaborative approach to healthcare, encouraging patients to find a lead practitioner who can coordinate with other specialists for comprehensive care. Work with Dr. Beckman: Those who want to learn more about Dr. Beckman's approach to health and wellness are invited to book a complimentary 15-minute discovery call, which can be easily scheduled through her Instagram or website. Labs Unveiled - Mold and Organic Acid Testing Course: This groundbreaking course by Dr. Ashley Beckman, hosted at LabsUnveiled.com, is your ticket to mastery in the fight against mold toxicity. You'll become a proficient interpreter of urine mycotoxin testing and master key protocols for mold and organic acid testing. This comprehensive course will take you on a deep dive into the biology and pathology of mold toxicity, from understanding different mold species to exploring their impacts on human health. This conversation with Dr. Beckman sheds light on the critical aspects of dealing with complex health conditions like Lyme disease, emphasizing individualized care, comprehensive testing, and the significant role of genetics, nutrition, and detoxification. This episode is a must-listen for anyone dealing with Lyme disease or other complex health conditions.

DrBeen#52 Epstein Barr Virus (EBV) Reactivation in Long COVID Your long COVID symptoms may be due to the latent virus reactivation, especially Epstein Barr Virus (EBV) reactivation. Let's review some studies. DrBeen: Medical Education Onlinehttps://www.drbeen.com/ FLCCC | Front Line COVID-19 Critical Care Alliancehttps://covid19criticalcare.com/ URL list from Thursday, Apr. 6 2023 Stress-Induced Epstein-Barr Virus Reactivation - PMChttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470332/#:~:text=Overview%20of%20EBV%20Reactivation%20and%20the%20Lytic%20Cycle,%2C%20and%20late%20%5B56%5D. The prevalence and long-term health effects of Long Covid among hospitalised and non-hospitalised populations: a systematic review and meta-analysis - eClinicalMedicinehttps://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(22)00491-6/fulltext Investigation of Long COVID Prevalence and Its Relationship to Epstein-Barr Virus Reactivation - PMChttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233978/ Positive Epstein–Barr virus detection in coronavirus disease 2019 (COVID-19) patients | Scientific Reportshttps://www.nature.com/articles/s41598-021-90351-y Frontiers | Saliva antibody-fingerprint of reactivated latent viruses after mild/asymptomatic COVID-19 is unique in patients with myalgic-encephalomyelitis/chronic fatigue syndromehttps://www.frontiersin.org/articles/10.3389/fimmu.2022.949787/full JCI - Chronic viral coinfections differentially affect the likelihood of developing long COVIDhttps://www.jci.org/articles/view/163669 COVID isn't just infecting you—it could be reactivating viruses that have been dormant in your body for years | Fortune Wellhttps://fortune.com/well/2022/12/26/is-long-covid-chronic-fatigue-syndrome-myalgic-encephalomyelitis/ SARS-CoV-2 infection triggers reactivation of latent viruses in people with chronic fatigue syndromehttps://www.news-medical.net/news/20221116/SARS-CoV-2-infection-triggers-reactivation-of-latent-viruses-in-people-with-chronic-fatigue-syndrome.aspx Impact of Pre-Existing Chronic Viral Infection and Reactivation on the Development of Long COVID - PMChttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327632/ Long COVID: major findings, mechanisms and recommendations | Nature Reviews Microbiologyhttps://www.nature.com/articles/s41579-022-00846-2 Impact of Pre-Existing Chronic Viral Infection and Reactivation on the Development of Long COVID | medRxivhttps://www.medrxiv.org/content/10.1101/2022.06.21.22276660v2 What Have We Learned about Long COVID? | Columbia University Irving Medical Centerhttps://www.cuimc.columbia.edu/news/what-have-we-learned-about-long-covid Donate to the Front Line Covid-19 Critical Care Alliance, Inc.https://frontlinecovid-19criticalcarealliance.salsalabs.org/donate/index.html Subscribe to our mailing list on our website: http://flccc.net/signup Disclaimer:This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.

In this captivating interview, Dr. Jill Carnahan sits down with renowned functional medicine expert, Dr. Kasia Kines, to dive deep into the mysterious world of the Epstein Barr Virus (EBV). If you've ever experienced unexplained fatigue or have been diagnosed with EBV, this video is a must-watch.

In this episode of "The Just M.S. Show", Justin Loizos breaks down exciting new research exploring the links between the Epstein-Barr Virus (EBV) and multiple sclerosis (MS). With EBV infecting over 90% of the global population and increasing the risk of MS by 32 times, Justin discusses how the body's response to the virus may inadvertently lead to damage in our nervous system. Join Justin as he navigates the complexities of this research and its implications for MS patients. He highlights the importance of personalized therapies and the potential of T cells in future MS research. Tune in for an informative and hopeful discussion on the evolving understanding of MS. Source: https://neurosciencenews.com/ms-progression-epstein-barr-23265/The Just MS (Multiple Sclerosis) Show, w host Justin Loizos, is a podcast that connects, educates and tries to uplift others living with multiple sclerosis. It provides real-life stories, interviews, and information about DMTs (disease modification therapies) and updates on research developments.www.justmultiplesclerosis.com

Epstein-Barr Virus(EBV) a.k.a. “Mono” or the “Kissing Disease”, Cytomegalovirus (CMV), and the lessor known Adenovirus (AV) (all are forms of Herpes Virus), have been the cause of misery and suffering for decades, even centuries in people around the world. They are leading causes Chronic Fatigue Syndrome a.k.a. “Cfers” and cause a host of symptoms from severe fatigue to muscle and joint pain, well the list is very long. One method of Intravenous Ozone Therapy has been proven over the last three decades to eliminate it, permanently, completely, once and for all and even CURE it!

Epstein-Barr Virus(EBV) a.k.a. “Mono” or the “Kissing Disease”, Cytomegalovirus (CMV), and the lessor known Adenovirus (AV) (all are forms of Herpes Virus), have been the cause of misery and suffering for decades, even centuries in people around the world. They are leading causes Chronic Fatigue Syndrome a.k.a. “Cfers” and cause a host of symptoms from severe fatigue to muscle and joint pain, well the list is very long. One method of Intravenous Ozone Therapy has been proven over the last three decades to eliminate it, permanently, completely, once and for all and even CURE it!

Epstein-Barr Virus(EBV) a.k.a. “Mono” or the “Kissing Disease”, Cytomegalovirus (CMV), and the lessor known Adenovirus (AV) (all are forms of Herpes Virus), have been the cause of misery and suffering for decades, even centuries in people around the world. They are leading causes Chronic Fatigue Syndrome a.k.a. “Cfers” and cause a host of symptoms from severe fatigue to muscle and joint pain, well the list is very long. One method of Intravenous Ozone Therapy has been proven over the last three decades to eliminate it, permanently, completely, once and for all and even CURE it!

Dr. Rade interviews Dr. Holland, a renowned expert in the field of Epstein-Barr Virus (EBV) and complex chronic illness.  They discuss a range of topics including EBV (of course!), mold, histamine issues, and more!   Dr. Holland's website: https://drkaseyholland.com/   Link to book a discovery call with Dr. Holland: https://drkaseyholland.com/appointments/   Dr. Holland's EBV Bootcamp: https://drkaseyholland.com/services/courses/   Dr. Holland's Instagram page: https://www.instagram.com/drkaseyholland/   To join Dr. Rade's mailing list to get free access to the first two parts of his Overcoming Chronic Illness Course: https://eastcoastnaturopathic.com/dr-bryan-rade-mailing-list

Thyroid Talk with Dr. Angela Mazza, DO  Recorded Friday, December 16, 2022SHOW NOTES EPISODE 14Epstein-Barr Virus & the Thyroid Host: Dr. Angela Mazza, DOCo-host: Dawn Sheffield I'm Dr. Angela Mazza, D.O., a thyroid, endocrine, and metabolism specialist with a private practice in Central Florida.  My goal for this podcast is to define and demystify the thyroid gland, and thyroid-related medical conditions.  By providing information in an easy-to-understand format, we hope to help patients better understand the ways in which their bodies work, and to help them thrive.  My goal is to help us live more fulfilling lives by taking control of our health, to feel our best. I wanted to do this podcast to provide life-saving education and encourage patients to see a doctor in time to prevent or minimize damage.  That's deeply fulfilling.  I enjoy helping folks understand how all aspects of their lives are tied to both thyroid and overall health.   In fact, this is why I went into endocrinology.  It's a medical art that combines science with the study of our lives—and all that they encompass.   To recap just some of what we covered in today's episode, not necessarily in this order:·       Epstein-Barr virus (EBV) is a common virus, and it's associated with Hashimoto thyroiditis;·       How Hashimoto thyroiditis can develop;·       EBV's four stages, and how it can spread;·       Vaccine development for EBV;·       EBV can reactivate in certain individuals, and worsen symptoms associated with autoimmune thyroid disease;·       Other conditions EBV can contribute to;·       Stress and lifestyle management, as well as nutraceutical therapies can help manage EBV reactivation;·       Tests to help chart a plan of action if EBV involvement is suspected;·       When might EBV testing be considered?;·       And best of all, we learned that we CAN impact our thyroid health!  For information on supplements mentioned in various episodes of this podcast, please visit the Wellness Store at metaboliccenterforwellness.com  Soon to be available for pre-order: “Thyroid Talk: An Integrative Endocrinologist's Guide to Optimal Thyroid Health” by Dr. Angela Mazza.  Citations, references, additional information re: materials mentioned in this episode:·       Campbell AW. Autoimmunity and the gut. Autoimmune Dis. 2014; Epub 2014 May 13.·       Dittfeld A, Gwizdek K, Michalski M, Wojnicz R.  A possible link between the Epstein-Barr virus infection and autoimmune thyroid disorders.  Cent Eur J Immunol 2016;41(3):297-301.·       Janegova A, Janega P, Rychly B, Kuracinova K, Babal P. The role of Epstein-Barr virus infection in the development of autoimmune thyroid disease. Endokrynol Pol 2015;66(2):132-6. ·       Pyzik A, Grywalska E, Matyjaszek-Matuszek B, Ludian J, Kiszczak-Bochyńska E, Smoleń A, Roliński J, Pyzik D. Does the Epstein-Barr virus play a role in the pathogenesis of Graves' disease? Int J Mol Sci 2019 Jun 27;20(13):3145·       https://www.niaid.nih.gov/news-events/nih-launches-clinical-trial-epstein-barr-virus-vaccine·       Mazza A.  Thyroid Talk: An Integrative Endocrinologist's Guide to OptimaCheck out our YouTube channel - Dr. Angela Mazza, our website at Metabolic Center for Wellness, our FaceBook and our Instagram page.

Hey #fitfam! On this Fused Fitness Formula ep I dive into my own health journey to share with our listeners my past and background in the health space. From being 30 lbs overweight, feeling lost and uncertain about my future to shifting my perspective and use my circumstances to make healthy habit changes. I share my struggles along the way (not just physical but also mental/emotion which can certainly impact the physical). And I talk about my most recent health issues and why they've taught me about how to look at our health with a different lens which has COMPLETELY changed how I help my members look at their health and their efforts. This is an ep you don't want to miss! It's filled with gems that could be helpful with how you approach your health journey!

Research Update: Epstein-Barr Virus and MS - Episode 65 - Transcript Join Dr. Rosalind Kalb as she interviews Dr. Alberto Ascherio, Professor of Epidemiology and Nutrition at the Harvard School of Public Health. Alberto is a lead researcher on the correlation between Epstein-Barr Virus (EBV) and Multiple Sclerosis. In this podcast, we'll seek to answer questions like – what are the implications for someone who already has MS? Does EBV play a role in the ongoing MS disease process? How close are we to an EBV vaccine? And what does this mean for future generations? Learn answers to these quesitons and more during our fascinating conversation.

The Long Story Short with Dr. Been Epstein Barr Virus (EBV) Serology Dr. Been reviews the serology of the Epstein Barr Virus (EBV). EBV causes Infectious Mononucleosis. This disease is usually benign and self limiting. However, in some cases it can become chronic, or reactivating. EBV can also cause cancers and other serious complications. Original video from Dr. Been posted in August 2021 Please see Odysee for more detailed links on subjects discussed. Disclaimer: This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.

The Long Story Short with Dr. Been Epstein Barr Virus (EBV) - Long COVID Dr. Been reviews a study showing that the long-covid is associated with reactivated EBV. He provides an overview of EBV and infectious mononucleosis. Original video from Dr. Been posted in August 2021 ReferencesEBV and Mono on Wikipedia https://en.wikipedia.org/wiki/Epstein%E2%80%93Barr_virus https://en.wikipedia.org/wiki/Infectious_mononucleosis https://neurology.testcatalog.org/show/SEBV https://www.infectiousdiseaseadvisor.com/home/decision-support-in-medicine/infectious-diseases/epstein-barr-virus-ebv/ https://www.researchgate.net/figure/Dynamics-of-anti-EBV-antibody-responses-over-time-during-primary-infection_fig2_283439011 https://en.wikipedia.org/wiki/Reactive_lymphocyte Disclaimer: This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional. dr beenepstein-barr virusflccclong haul covidthe long story short

The Long Story Short with Dr. Been Epstein Barr Virus Reactivation in COVID Dr. Been reviewed a study from China published in May 2021 concluding a high incidence of EBV co-infection in COVID-19 patients. EBV/SARS-CoV-2 coinfection was associated with fever and increased inflammation. EBV reactivation may be associated with the severity of COVID-19. The reactivation of EBV may also be the cause of the COVID long haul symptoms. Original video from Dr. Been posted in August 2021 About infectious Mononucleosis: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670567/ Study published in nature on May 21st 202: https://www.nature.com/articles/s41598-021-90351-y Disclaimer: This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.

The Long Story Short with Dr. Been Evidence of Epstein Barr Virus Reactivation in Long COVID Patients Dr. Been reviews a study published on June 17th 2021 that shows that 30% of COVID long-haul patients have EBV reactivation. He reviews the study and the evidence presented. Original video from Dr. Been posted in August 2021 Reference to the study:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233978/ Other studies supporting the evidence of EBV in COVID long-haul: https://pubmed.ncbi.nlm.nih.gov/28956548/ https://pubmed.ncbi.nlm.nih.gov/2987786/ https://pubmed.ncbi.nlm.nih.gov/231279/ Disclaimer: This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.

Like many people, Melissa Gallagher, ND, became interested in natural health and wellness when, in 2003, she suffered from a very severe case of Epstein Barr Virus (EBV).  EBV crippled her immune system and literally changed her life and view of preventative healthcare. If you read my blog, you will know that I have a […] The post Melissa Gallagher, ND, Diagnosing & Treating the Epstein-Barr Virus appeared first on LillianMcDermott.com.

Willkommen zu Folge #129 vom MS-Perspektive-Podcast. Heute begrüße ich Prof. Dr. Dr. Henri-Jacques Delecluse vom Deutschen Krebsforschungszentrum (DKFZ) in Heidelberg als Gast im Interview. Wir sprechen über die Bedeutung des Epstein-Barr-Virus (EBV) für die Entwicklung verschiedener Krebsarten, aber auch der Multiplen Sklerose. Von einer erfolgreichen Impfung könnten vermutlich viele Menschen profitieren, aber das Virus macht es den Forschern nicht einfach. Seit 40 Jahren wird bereits nach einem Impfstoff gesucht, doch bisher gibt es noch keine zugelassene Impfung gegen EBV.  Aktuell arbeiten sieben Firmen an einer Lösung. Wir sprechen über die Herausforderungen denen die Forscher begegnen, wie das Epstein-Barr-Virus das Immunsystem angreift und warum es für unser Immunsystem so schwierig ist das Virus zu eliminieren. Hier geht es zum Blogbeitrag: https://ms-perspektive.de/interview-mit-prof-dr-dr-hj-delecluse-zu-ebv-impfungen Vorstellung Prof. Dr. Dr. Henri-Jacques Delecluse ist seit 2003 Professor an der Uni Heidelberg. Er ist Abteilungsleiter am Deutschen Krebsforschungszentrum (DKFZ) in Heidelberg und erforscht die Pathogenese (Entstehung und Entwicklung) infektionsbedingter Tumore. Mit seiner Frau, die ebenfalls Ärztin ist, hat er drei Kinder. Zu seinen Hobbys gehören Gesang und Mathematik. Bedeutung des EBV-Virus Wie verbreitet ist das Epstein-Barr-Virus (EBV) in Deutschland und weltweit? Weltweit, also auch in Deutschland sehr verbreitet, über 95% der Bevölkerung über 50 sind infiziert. In welchem Alter / welcher Altersspanne infiziert sich der Großteil der Bevölkerung mit EBV? Es kommt darauf an wo auf der Welt, in Afrika sind die meisten Kinder vor dem ersten Geburtstag infiziert, in industrialisierten Ländern zwischen 15 und 25 Jahren. Welche Krankheiten stehen in Zusammenhang mit dem Epstein-Barr-Virus? Es stehen sehr viele Krankheiten in Zusammenhang, allen voran das Pfeiffersche Drüsenfieber, eine gutartige meist sich selbst zurückbildende Entzündung der Lymphknoten und des Rachenraums. Allerdings wird das Virus mitverantwortlich gemacht für die Entstehung von Tumoren des Nasopharynx, des Magens sowie des Lymphdrüsensystems wie etwa Morbus Hodgkin. Letztlich spielt das Virus eine entscheidende Rolle bei der Entwicklung von Multipler Sklerose und womöglich von anderen autoimmunen Krankheiten. Wieso forschen Sie am Deutschen Krebsforschungszentrum daran? Weil Krankheiten, die von Viren verursacht werden, leichter vorgebeugt oder therapiert werden können. Auch weil Herpesviren sehr komplex und interessant sind. Welche Bedeutung hat EBV für die Multiple Sklerose und warum ist der Zusammenhang so eindeutig? Man weiß, dass die relativ wenigen Menschen, die EBV nicht tragen, fast nie MS entwickeln, d.h. die Infektion ist Voraussetzung für ihre Entwicklung. Allerdings haben die meisten Menschen, die das Virus tragen keine MS. Also braucht man mehr als EBV, um MS zu entwickeln. Der Zusammenhang zwischen EBV und MS basiert auf epidemiologischen Studien. Letztere können eindeutige Zusammenhänge erkennen, wenn sie gut gemacht sind. Die Studien, die den Zusammenhang zwischen EBV und MS untersucht haben, sind mittlerweile sehr gut und liefern eindeutige Ergebnisse. Komplexität des Virus und seiner Wirkungsweise auf das Immunsystem Was ist das Besondere am Epstein-Barr-Virus? Es ist sehr großes und daher komplexes Virus, das sehr erfolgreich Menschen lebenslang infiziert, meist, aber eben nicht immer, ohne Konsequenzen für seinen Wirt. Welche Phasen gehören zu einer EBV-Infektion und wie sind sie zeitlich einzuordnen? Zunächst erfolgt die primäre Infektion, also der erste Kontakt mit dem Virus. Diese verläuft symptomlos oder höchstens mit einem milden grippalen Infekt in der Kindheit. Wenn man später infiziert wird, kann sich ein Pfeiffersches Drüsenfieber entwickeln, mit geschwollenen Lymphdrüsen und Mandeln, Fieber, Veränderung des Blutbildes und manchmal größeren Problemen wie Milzruptur oder Leberentzündung. Nach diesem ersten Kontakt bleibt das Virus im Körper, in den meisten Menschen ohne Konsequenzen. Bei manchen Menschen kann sich jedoch eine Krankheit entwickeln, jeder Zeit nach der ersten Infektion. Welche Zellen des Immunsystems greift das EBV-Virus an und wie schädigt es die Abwehrzellen? EBV infiziert sehr erfolgreich B-Lymphozyten und zwingt sie, sich zu vermehren. Wenn diese Vermehrung unbegrenzt bleibt, kann es zur Tumorbildung führen. In manchen Zellen werden jedoch neue Viren produziert, dabei sterben die Zellen ab. Ist die Wirkung der mehr als 30 Proteine, die jeder einzelne EBV-Virus beinhaltet, auf den menschlichen Körper bereits klar oder wird daran noch geforscht? Bei manchen Proteinen ist die Wirkung relativ klar, bei anderen weiß man sehr wenig bis gar nichts. Allgemein kann man sagen, dass die Rolle des Virus in der Krebsentstehung wenig bekannt bleibt, mit der Ausnahme von bestimmten Tumoren. Gibt es ein oder mehrere Proteine aus dieser großen Menge, die ein geeignetes Ziel für eine Impfung sind? Im Prinzip stellen alle Proteine ein mögliches Ziel dar, es sei denn sie haben schädliche Eigenschaften, wie die Fähigkeit Krebs auszulösen. Aktueller Stand der Forschung für mögliche EBV-Impfungen Seit wann wird an einem EBV-Impfstoff geforscht, und warum ist es so schwer, eine funktionierende Impfung zu entwickeln? Seit den 1980ern wird daran geforscht. Generell ist es schwer, gegen Herpesviren zu impfen, weil sie dem Immunsystem so gut entgehen können und sich in Zellen verstecken. In ihrem Versteck produzieren sie keine Proteine mehr und werden deshalb auch nicht mehr vom Immunsystem erkannt. Außerdem werden Menschen im Laufe der Zeit immer wieder vom Epstein-Barr-Virus infiziert. Deshalb wird es vermutlich nie einen absoluten Schutz gegen das Virus geben. Allerdings könnte eine Impfung die akuten Symptome der Infektion wie das Pfeiffersche Drüsenfieber möglicherweise mildern. Das würde wahrscheinlich wiederum die Frequenz mancher Tumore wie Morbus Hodgkin oder Krankheiten wie MS verringern. Sie haben sieben Ansätze für Impfungen gegen EBV untersucht. Welche davon sind besonders vielversprechend? Alle haben das Potential, wirksam zu werden, oder auch nicht. Manche werden T-Zellen besser stimulieren, andere die Antikörperproduktion. Da bis jetzt nur mit lebendigen abgeschwächten Viren eine erfolgreiche Impfung gegen Herpesviren erreicht wurde, wissen wir nicht, ob die anderen Technologien überhaupt funktionieren werden. Natürlich kann man aus ethischen Gründen eine Lebendvakzine beim Epstein-Barr-Virus nicht anbieten. Wie sieht es mit der mRNA-Technologie aus? Könnte diese Technik als Impfung gegen den EBV-Virus erfolgreich zum Einsatz kommen oder eher spezifisch für einzelne Erkrankungen, wie die MS? Die mRNA Technologie ermöglicht die schnelle Entwicklung von Impfstoffen. Allerdings ist die mRNA Technologie, wie wir es beim Coronavirus gesehen haben nicht effizienter als andere Strategien z.B. mit Vektoren oder mit rekombinanten Proteinen. Da es meines Wissens derzeit unmöglich ist, herauszufinden welche Menschen zukünftig MS entwickeln werden, sollte die gesamte Bevölkerung im Kindesalter geimpft werden. Es ist auch denkbar, dass die Impfung MS-Patienten nutzen würde, auch wenn sie bereits das Virus tragen. Allerdings ist das nur eine weit hergeholte Hypothese, die keineswegs bewiesen ist. Wer würde von einer erfolgreichen Impfung profitieren? Potentiell alle Menschen, da das Pfeiffersches Drüsenfieber relativ häufig vorkommt. Weiterhin würde die Impfung den 200.000 Krebsfällen, die jährlich von EBV verursacht oder mitverursacht werden, zu einem gewissen Teil vorbeugen. Und natürlich besteht die Hoffnung, dass die Impfung die Frequenz von Multipler Sklerose auch reduziert. Allerdings bleibt unklar, ob eine effiziente Impfung möglich ist. Welchen Durchbruch in der Forschung zu EBV-Impfstoffen wünschen Sie sich in den kommenden 5 Jahren? Eine erfolgreiche klinische Studie, die eben 5 Jahre Beobachtungszeit hat und beweist, dass Vakzinierung die Frequenz von EBV-assoziierten Krankheiten senken lässt. Wo können sich Patienten über den aktuellen Forschungsstand bezüglich EBV-Impfungen informieren? Ich selbst habe keine direkten Informationen. Die Firmen, die Impfungen entwickeln, werden bestimmt Werbung machen. Verabschiedung Möchten Sie den Hörerinnen und Hörern noch etwas mit auf dem Weg geben? Ich denke, dass die EBV-Forschung große Fortschritte macht. Es wird jedoch noch einige Jahre dauern, bevor die Wirkung der EBV-Impfung klar wird. ++++++++++++++++++++ Ich wünsche Dir bestmögliche Gesundheit, Nele Mehr Informationen rund um das Thema MS erhältst du in meinem kostenlosen MS-Letter. Hier findest Du eine Übersicht über alle bisherigen Podcastfolgen.

Epstein-Barr Virus (EBV) is best known for causing mononucleiosis, or the 'kissing disease,' in teenagers. Almost all adults get EBV at some point in their lives, even if they don't get mono. New research shows that EBV infection may have longer-lasting impacts. Using data from the American military, researchers now show that EBV infection drastically increases an individual's risk for multiple sclerosis, a debilitating autoimmune disorder. In this episode, Dan and Derek discuss how these researchers figured this out and potential ways to prevent EBV infection (and potentially multiple sclerosis) altogether. Bjornevik et al. Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis. Science, January 2022. DOI: https://doi.org/10.1126/science.abj8222 (10.1126/science.abj8222) The information presented here is not medical advice. Consult your physician on any questions regarding your personal health.

You name it. We EXPLAIN it! In this episode Robin Riddle, NP-C explains the Epstein-Barr Virus (most commonly known for causing Mononucleosis) and why it's important to know if you've had it or been exposed to it. What did you think of this episode of the podcast? Let us know by leaving a review! Connect with Performance Medicine! Sign up for our weekly newsletter: https://performancemedicine.net/doctors-note-sign-up/ Facebook: @PMedicine Instagram: @PerformancemedicineTN YouTube: Performance Medicine

Now that Harvard researchers have presented compelling evidence that MS is triggered by the Epstein-Barr Virus (EBV), what does it mean in terms of ending MS in the world? What does it mean for people already living with MS? And how will this announcement impact MS research? Joining me to unpack the details and implications of this research breakthrough is the Executive Vice-President of Research for the National MS Society, Dr. Bruce Bebo. We're also talking about new research from Stanford University that shows how EBV triggers MS.  We'll share the results of a study that shows cognitive dysfunction can increase the risk of death for people living with MS. We'll give you the details of the $600,000 grant that was awarded to develop a behavioral therapy intervention designed to improve the quality of life for people living with MS. And if you'd like to be able to say, "I helped develop a cure for MS," we'll tell you how. We have a lot to talk about! Are you ready for RealTalk MS??! A Stanford research team discovers how EBV triggers MS  1:18 A biotech company announces they will develop a therapy to kill EBV-inifected cells in people living with MS  4:03 Study shows cognitive dysfunction increases risk of death for people living with MS  5:34 $600,000 awarded to develop a behavioral therapy intervention that will improve quality of life for people living with MS  8:44 Now is the perfect time for you to get involved with iConquer MS  10:58 Dr. Bruce Bebo discusses the implications and next steps following the presentation of evidence showing EBV triggers MS   13:04 Share this episode  28:35 Download the RealTalk MS app for your iOS or Android device   28:56 SHARE THIS EPISODE OF REALTALK MS Just copy this link & paste it into your text or email:  https://realtalkms.com/231 ADD YOUR VOICE TO THE CONVERSATION I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts! Email: jon@realtalkms.com Phone: (310) 526-2283 And don't forget to join us in the RealTalk MS Facebook group! LINKS If your podcast app doesn't allow you to click on these links, you'll find them in the show notes in the RealTalk MS app or at www.RealTalkMS.com National MS Society COVID-19 Vaccine Guidance for People Living with MS https://www.nationalmssociety.org/coronavirus-covid-19-information/multiple-sclerosis-and-coronavirus/covid-19-vaccine-guidance National MS Society Third COVID-19 Vaccine Dose Guidance for People Living with MS https://www.nationalmssociety.org/About-the-Society/News/Additional-COVID-19-Vaccine-Dose-(Booster)-and-MS STUDY: Clonally Expanded B Cells in Multiple Sclerosis Bind EBV EBNA1 and GlialCAM https://nature.com/articles/s41586-022-04432-7 STUDY: Cognitive Dysfunction and Mortality in Multiple Sclerosis: Long-Term Retrospective Review https://journals.sagepub.com/doi/10.1177/13524585211066598 iConquer MS https://iconquerms.org Join the RealTalk MS Facebook Group https://facebook.com/groups/realtalkms Download the RealTalk MS App for iOS Devices https://itunes.apple.com/us/app/realtalk-ms/id1436917200 Download the RealTalk MS App for Android Deviceshttps://play.google.com/store/apps/details?id=tv.wizzard.android.realtalk Give RealTalk MS a rating and review http://www.realtalkms.com/review Follow RealTalk MS on Twitter, @RealTalkMS_jon, and subscribe to our newsletter at our website, RealTalkMS.com. RealTalk MS Episode 231 Guests: Dr. Bruce Bebo Tags: MS, MultipleSclerosis, MSResearch, MSSociety, RealTalkMS Privacy Policy

Today we chat with Dr. Kasey Holland, a naturopathic physician, about EBV aka Epstein-Barr Virus! Why EBV? Because it's a common viral infection that can leave many people with crippling symptoms- including chronic fatigue, autoimmune disease (MS, RA, or Hashimoto's included), swollen lymph nodes, muscle or joint pains, enlarged liver/spleen, and hormone imbalances. Listen and learn! My info: Website: www.upliftfitnutrition.com Instagram: www.instagram.com/faithandfit Twitter: www.twitter.com/laceyadunn Email for coaching & phone consults: laceydunn@upliftfitnutrition.com Order my book "The Women's Guide to Hormonal Harmony" on amazon! https://www.amazon.com/gp/product/0578884127/ref=dbs_a_def_rwt_bibl_vppi_i1 Find Dr Kasey at: www.instagram.com/drkaseyholland www.drkaseyholland.com --- Support this podcast: https://anchor.fm/upliftfitnutrition/support

Last week, a research team at the Harvard T.H. Chan School of Public Health presented compelling evidence that the Epstein-Barr Virus (EBV) triggers multiple sclerosis. So, we're taking a deep dive into the role of EBV and MS. We'll review the breakthrough results of this research and we'll re-share our conversation with one of the researchers in this game-changing study. We'll review the status of an experimental cell therapy that's designed to remove the EBV virus from infected b-cells in people with progressive MS. And we'll update you on a clinical trial that's underway to test an EBV vaccine. We have a lot to talk about! Are you ready for RealTalk MS??! Researchers at Harvard present compelling evidence that Epstein-Barr Virus (EBV) triggers MS  :22 Dr. Kassandra Munger discusses EBV and MS   4:41 What else do we still need to know?  13:28 ATA-188, EBV, and MS  14:06 Dr. AJ Joshi discusses what scientists are learning from the ATA-188 clinical trial  14:49 What about an EBV vaccine?   27:21 What??? Magic???  28:33 Share this episode  30:23 Be sure to catch MS Got Talent  30:43 SHARE THIS EPISODE OF REALTALK MS Just copy this link & paste it into your text or email:  https://realtalkms.com/229 ADD YOUR VOICE TO THE CONVERSATION I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts! Email: jon@realtalkms.com Phone: (310) 526-2283 And don't forget to join us in the RealTalk MS Facebook group! LINKS If your podcast app doesn't allow you to click on these links, you'll find them in the show notes in the RealTalk MS app or at www.RealTalkMS.com National MS Society COVID-19 Vaccine Guidance for People Living with MS https://www.nationalmssociety.org/coronavirus-covid-19-information/multiple-sclerosis-and-coronavirus/covid-19-vaccine-guidance National MS Society Third COVID-19 Vaccine Dose Guidance for People Living with MS https://www.nationalmssociety.org/About-the-Society/News/Additional-COVID-19-Vaccine-Dose-(Booster)-and-MS STUDY: Longitudinal Analysis Reveals High Prevalence of Epstein-Barr Virus Associated with Multiple Sclerosis https://science.org/doi/10.1126/science.abj8222 MS Got Talent LIVE on Jan. 29th at 7PM Eastern/4PM Pacifichttps://mssociety.donordrive.participant/msgottalent or https://twitch.tv/mssociety Join the RealTalk MS Facebook Group https://facebook.com/groups/realtalkms Download the RealTalk MS App for iOS Devices https://itunes.apple.com/us/app/realtalk-ms/id1436917200 Download the RealTalk MS App for Android Deviceshttps://play.google.com/store/apps/details?id=tv.wizzard.android.realtalk Give RealTalk MS a rating and review http://www.realtalkms.com/review Follow RealTalk MS on Twitter, @RealTalkMS_jon, and subscribe to our newsletter at our website, RealTalkMS.com. RealTalk MS Episode 229 Guests: Dr. Kassandra Munger,  Tags: MS, MultipleSclerosis, MSResearch, MSSociety, EBV, EpsteinBarr, RealTalkMS Privacy Policy

Amanda Rojas is a 31-year-old medical collections supervisor. She is planning on continuing her college education soon and wants to help others navigate through the craziness of Lyme disease. Ms. Rojas' battle with Lyme began at Christmas time when she was 25 years old. She visited over 30 doctors, specialists, urgent care facilities, and hospitals, but none of them could discover the root cause of her problems. Many doctors misdiagnosed Ms. Rojas with psychological disorders and other conditions like Fibromyalgia and Epstein Barr Virus (EBV). Eventually, she found a Naturopathic Doctor (ND) who diagnosed her with Lyme disease through a Vibrant Labs test. Ms. Rojas started treating using the kill, bind, and sweat treatment method which kickstarted her healing. She continued her treatment journey by visiting LymeStop. Most recently, she has started Vital Side Brain retraining to heal her limbic system. If you would like to learn more about how a driven young woman located her Lyme disease diagnosis and treatment by never giving up and continuing to take action, then tune in now!

Join me for episode 48 where we talk with my client, Tena Strok, who was interested in the MAP Method to address immune and limbic system dysregulation as well as chronic Epstein Barr Virus (EBV), and sensitivities to mold and foods. Hear about the benefits she experienced from four sessions including mental/emotional shifts and improvement of her physical symptoms. In this episode we discuss: - How Tena made the connection between a dysregulated limbic system, immune dysfunction and her chronic health issues. - How stressful events exacerbated her symptoms and how that has improved with MAP Method sessions. - How traumatic experiences can alter the function of the limbic system and cause the immune system to overreact to relatively harmless stimuli (foods, airborne irritants) and underreact to true threats (bacteria, virus, fungus). - The stressors that precipitated the decline in her health. - Tena's interest in resolving the root cause to improve the function of her immune system, and alleviate the symptoms. - Her perception of her brain activity in response to MAP instructions and how that differs from most people. - How the emotional intensity of memories is neutralized during a session and how this changes mental, emotional and physical patterns. - Why she is “sold on” the MAP Method and the benefits it provides. - The benefits she observed after MAP sessions, including feeling less compulsive about needing to maintain communications with others. - The gradual breaking down of emotional, behavioral or physical patterns over the course of a set of MAP sessions. - The improvements in her chronic symptoms after each session, including chronic EBV and sensitivities. Don't miss episode 45 where we hear from my client Rachael Royce about the benefits of the MAP Method for COVID long-haulers. For more information about the MAP Method, applications for chronic health issues, or to schedule a free consultation by phone, please visit MindReMAPforHealth.com

COVID has been sweeping the globe for almost two years now, and social media has exponentially heightened our awareness of this deadly virus. However, the media and medical attention that the virus has received often overshadows other life-threatening viruses. Over the past five years, obesity, specifically in the United States, has reached alarming new heights, but has obtained far less media and medical attention than COVID-19. On today's episode, co-hosts Vince and Erica shed light on the effects obesity has on society and what steps we need to take to beat obesity and other viruses that have not been prioritized due to the pandemic.   Vince addresses the detrimental effects of COVID-19 on the world's obese population from his background in functional medicine. Seventy eight percent of the individuals who have died COVID-related deaths over the past two years were obese. Vince explains that the only way to effectively reduce obesity rates is through the creation of a free, worldwide health services and education initiative. Erica shares her experience with getting COVID and how it triggered another virus she assumed was at bay: the Epstein Barr Virus (EBV). Because COVID was able to penetrate her immune system and stir up other viruses hibernating in her body, Erica is still dealing with the repercussions of EBV over a year after getting COVID-19. Erica explains that COVID feeds on preexisting health conditions such as other viruses, poor health, and obesity.  Tune into this week's episode of the E3 Podcast to learn more about the effects of obesity on our nation's health. Learn about how COVID-19 targets your body's weaknesses, what happens to your body when you become obese and how to clean up your diet in a healthy way.  Today's food for thought from co-host Erica: “It's not a no. It's a not right now.”   Quotes • “It's not a no. It's a not right now.” (0:08:19-0:08:24 | Erica)  • “When you give statistics without context, in a way you are kind of lying.” (0:27:08- 0:27:13 | Vince) • “There are people that have an initial immune response that is very strong, and there are people who have a secondary immune response that are very strong, and both have problems.” (0:38:54-0:39:06 | Vince)  • “So I had COVID, didn't know it, and then I was fine. And then all of a sudden, my EBV symptoms started to flare up.” (0:48:33-0:48:37 | Erica)  • “You know, these things are crucial, because if you reduce that inflammatory load, you improve immune function.” (1:00:34-1:0045 | Vince)    Links Follow Erica on IG: https://instagram.com/ericafitlove?utm_medium=copy_link Follow Vince on IG: 
https://instagram.com/vince_pitstick?utm_medium=copy_link Learn more about the E3 Podcast: 
https://instagram.com/e3_podcast?utm_medium=copy_link Check out our YouTube channel: 
https://youtu.be/BtZjWT9VYv8

Epstein-Barr Virus is one of the most common human herpes viruses that many people will get at some point in their lives. I'm joined by Dr. Kasia Kines to talk about how to make your body an inhabitable host for the Epstein-Barr Virus.   The 3 Worst Offenders When You Have Chronic EBV Intermittent Fasting Exercise Ketogenic Diet   About Dr. Kasia Kines Dr. Kines is the CEO and Founder of Global Epstein-Barr Virus Institute, a global leader in recovery therapy for chronic EBV, an Amazon best-selling author of The Epstein-Barr Virus Solution, a wellness expert, and a highly respected doctor of clinical nutrition.  She is a graduate of Bastyr University, the "Harvard of Natural Medicine" and its world-acclaimed graduate nutrition program. She was also in the first-ever cohort of a doctorate in functional clinical nutrition from the Maryland University of Integrative Health.  Since 2005, Dr. Kines has built an international reputation as a clinical functional nutritionist, from being sought after by Johns Hopkins University to clients globally, to her ground-breaking book about Epstein-Barr Virus.  Dr. Kines has developed a proprietary evidence-based methodology and approach to EBV recovery, which is now available to anyone in her highly successful EBV Recovery Program. She also provides professional clinical training to other practitioners in her Clinical EBV Training and Certification Program and EBV Practitioner Workshop.  Dr. Kines is a passionate advocate for debunking common misinformation about EBV in the medical community and lectures on this topic extensively. She is on a mission to bring her EBV knowledge and solution to the world globally, so no one needs to suffer needlessly from this misunderstood virus and its complications.   What is Epstein-Barr Virus? Epstein-Barr Virus (EBV) expert, Dr. Kasia Kines, breaks down what exactly this virus is and how it impacts our bodies and long-term health projections. She explains what some of the typical symptoms of EBV are and what four lab tests you should get checked if you think you have it.  Some of the symptoms include feeling tired all the time, having swollen lymph nodes and a sore throat, and a lowered immune system. Dr. Kines also talks about whether you should do any kind of dietary detox when battling EBV. Overall, she promotes a healthy diet that will increase your nutritional status, making you a less habitable host for the Epstein-Barr Virus.   Dietary Changes to Tackle EBV Dr. Kines recommends making some dietary changes if you have EBV. Cutting out gluten, dairy, and eggs, in particular, can make a huge improvement to your symptoms of the virus. She also advises increasing your consumption of fruits, gluten-free grains, and legumes. These are full of antioxidants that incapacitate the virus, making it more difficult to spread and control your body. Eating a diet rich in plant-based foods, low in gluten, and completely without dairy and eggs will be very beneficial for someone with EBV. Dr. Kines advises against following the Keto diet or intermittent fasting as these can have a detrimental effect on your body and the voracity of the virus. Do you have any of the symptoms of the Epstein-Barr Virus? If so, have you cut gluten, dairy, and eggs out of your diet? How are you feeling after doing this? Call the Integrative Health and Hormone Clinic today and schedule your first appointment at 319-363-0033.   Quotes “The weak link is where the virus will go. The virus will travel through the blood and look for residence in any tissue. … It has to go somewhere. Just like you talk about the house, I often teach my students that we're building a really solid brick house that has to start with foundations.” [10:45] “Gluten should not be in the diet and dairy is super inflammatory. There is no place for dairy in the healing process for the human body. Especially not the way that dairy is produced. And for a person with EBV, dairy will really backfire on them.” [26:52] “Another thing that people do wrong is not eating enough fruits. Fruits have the highest antioxidant load and antioxidants incapacitate the virus. I literally have to retrain people to eat larger portions of fruits.” [28:47] “If you want to simplify it, the better nutritional status, the weaker the virus. We have the responsibility to provide the best nutrients.” [34:07] “If a virus is predictable, it is treatable and reversible and sometimes rapidly. And I'm quoting.” [50:18]   In This Episode What Epstein-Barr Virus (EBV) is [9:00] The common symptoms of chronic EBV [15:30] Four labs to test for EBV [23:00] What dietary changes should you explore with EBV [26:00] Why you should increase your consumption of grains and legumes [30:00] Benefits of increasing plant-based food in your diet [34:30] The role of antioxidants in a diet [28:00] How important detoxification is to anti-viral support and treating EBV [43:00]   Links & Resources Use Code VITAMIND for 10% Off Vitamin D Use Code IMMUNESUPPORT 10% Off Immune Support Read: Emfs: Why They Are Dangerous To Your Health And What You Can Do About Them! Your Longevity Blueprint Course Now 50% Off Take the Quiz: Could you have Chronic Active Epstein-Barr Virus infection? Learn More About the EBV Recovery Program Find Out About the EBV Practitioner Workshop Take the 5-in-5 Mini-Course Get the Book: The Epstein-Barr Virus Solution Find Dr. Kasia Kines Online Find The EBV Global Institute Online Follow Dr. Kasia Kines on Instagram | Facebook | Twitter | YouTube | LinkedIn | Pinterest Find Your Longevity Blueprint Online Follow Your Longevity Blueprint on Instagram | Facebook | Twitter | YouTube | LinkedIn Get your copy of the Your Longevity Blueprint book and claim your bonuses here Find Dr. Stephanie Gray and Your Longevity Blueprint online    Follow Dr. Stephanie Gray on Facebook | Instagram | Youtube | Twitter | LinkedIn Integrative Health and Hormone Clinic Podcast Production by the team at Counterweight Creative    Related Episodes Episode 14: Supporting The Mitochondria With Nad And Peptides W/ Dr. Amber Krogsrud Episode 67: A Different Kind Of Healing With Dr. Shiroko Sokitch Episode 49: Power Of Pemfs With Dr. William Pawluk

With the fires blazing, burning longer and more frequently in some northern latitudes, we wanted to resurface one of our favorite conversations with Kasia Kines on Epstein-Barr Virus (EBV). EBV is one of the eight known herpes viruses. While it's one of the most common human viruses on the planet, and while most carriers do […] The post #49: Mapping EBV with Dr. Kasia Kines (Replay) appeared first on Functional Nutrition Alliance.

Herzlich willkommen zu dieser Episode! Heute geht es um das Epstein Barr Virus, den Verursacher des Pfeifferschen Drüsenfiebers, von Krebserkrankungen und Trigger von chronischen Erkrankungen wie Neurodermitis, Hashimoto, Multiple Sklerose, rheumatoide Arthritis, Fibromyalgie u.a.. Ich gehe auf viele Communityfragen ein, z.B. wie man eine EBV Infektion merkt, was man bei EBV tun kann, ob es wirklich chronische Erkrankungen verursacht, ob es bereits wirksame Therapiemöglichkeiten wie Impfungen gibt und inwieweit Selleriesaft wirklich hilft. Hör rein! Teile die Episode und lass mir eine positive Bewertung da! Danke Dir! Deine Dorothea Wenn Du weitere Fragen hast, dann schreib sie mir auf Instagram oder Youtube. Alle Links zu Dorothea Leinung: Website: https://www.dorothealeinung.com/ Instagram: https://www.instagram.com/dr.med.dorothea.leinung/ Youtube: https://www.youtube.com/channel/UC2zPCFlSKQagWjGKgP4YqXA

In 2012, while studying at university, Mimi Butlin contracted viral meningitis — from which she never fully recovered. Since then she has been diagnosed with Ehlers-Danlos syndrome, fibromyalgia, postural orthostatic tachycardia syndrome, and ME/CFS (as Mimi wryly notes, “a really lovely bunch!”). For years, she felt completely alone and that convinced she was responsible for her pain. In 2018, she started the Instagram account @CantGoOut_ImSick, a platform where she posted drawings of what living with illness was like — including portraits of other chronically ill women who had gone through similar experiences. Because of her work, including the #BelieveUs campaign, she has been featured in Women’s Health magazine, Grazia magazine, and on Refinery29 and Bustle. Recently, she collaborated with disability charity Leonard Cheshire to create the #DisabledLooksLikeMe campaign to raise awareness of invisible disabilities. Mimi is very proud of what was achieved throughout the campaign, which saw disabled influencers, creatives, and celebrities — such a Selma Blair and Sinead Burke!! — wearing her t-shirts and supporting the campaign on social media. She is currently taking a break from her work in order to accommodate her health (and wow, can we relate), but she’s extremely grateful to the people she has met along the way, who have helped her accept her conditions and feel proud of who she is. Tune in as Mimi shares: that of all her symptoms, chronic pain is most in control of her day-to-day that she was diagnosed with viral meningitis, and subsequently with Epstein-Barr Virus (EBV, or mono) and gastroenteritis — multiple times — and never fully recovered a discussion of access issues in healthcare, including the NHS and optional paid enhancements why doctors have a responsibility of care — both emotional and physical how mental health and medical PTSD have played a role in her health experience how she first received notice for her art — from fellow Spoonie, Lena Dunham! how her illnesses changed her relationship with her mum why she recommends those who identify as female bring a cis man with them as an advocate in doctors’ appointments her experiences of not being believed by medical practitioners who has inspired her in the disability community how she’s cultivated pride in her health status how research can give you perspective on your experience — and the experiences of others

In this episode, Tavia talks about the virus called Epstein Barr virus She discussed what it is, how you can get it and the surprising facts around this common virus. Epstein Barr virus is also known as MONO. It is a virus that is in the herpes family. EBV is very common, most people contract it by kissing another person or thru the saliva of another person.Tavia discusses the correlation between EBV and Lyme disease. She discusses why you need to also look for Lyme disease when you have a EBV diagnosis. She also discusses how EBV will potentially hide a lyme diagnosis.Listen to learn why co infections like EBV, Babesia, Bartonella, Erlichia, Rikketsia, RMSF, Mycoplasma are also essential to look at when seeking better health answers.For more info go to www.healthcoachtavia.com

In this episode, Tavia talks about the virus called Epstein Barr virus She discussed what it is, how you can get it and the surprising facts around this common virus. Epstein Barr virus is also known as MONO. It is a virus that is in the herpes family. EBV is very common, most people contract it by kissing another person or thru the saliva of another person.Tavia discusses the correlation between EBV and Lyme disease. She discusses why you need to also look for Lyme disease when you have a EBV diagnosis. She also discusses how EBV will potentially hide a lyme diagnosis.Listen to learn why co infections like EBV, Babesia, Bartonella, Erlichia, Rikketsia, RMSF, Mycoplasma are also essential to look at when seeking better health answers.For more info go to www.healthcoachtavia.comThe Sweet Life Coaching Podcast https://businessinnovatorsradio.com/the-sweet-life-coaching-podcast/Source: https://businessinnovatorsradio.com/ep-11-coach-tavia-morse-functional-nutritional-health-coach-talks-about-epstein-barr-virus-ebv-and-lyme-relation

Oxidative stress is often over complicated and today Dr. Kasey Holland Hamski helps to simplify what oxidatives stress is, while illustrating the complexities in the connections between oxidative stress and reactivated Epstein-Barr Virus (EBV). Dr. Kasey gracefully takes us around the matrix and shows the many ways that oxidative stress is manifested and expressed in many parts of the body. This episode is chock-full of clinical pearls! Click here to download the completed Matrix from this week’s episode To learn more about Dr. Kasey click here Click here for Dr. Kasey’s blog Related Episodes Episode #49 where Dr. Kasia Kines maps Epstein-Barr Virus (EBV) on the 15-Minute Matrix Episode #27 where Dr. Jill Carnahan maps Toxic Mold on the 15-Minute Matrix Episode #178 where Dr. Ben Lynch maps Homocystine on the 15-Minute Matrix Episode #138 where Dr. Mansoor Mohammed maps Methylation on the 15-Minute Matrix Episode # 69 where Dr. Jill Crista maps PANS/PANDAS on the 15-Minute Matrix Get 15-Minute Matrix podcast notifications delivered to your inbox!

In this week's episode, I'll be sharing my interview with neurologist, Dr. Bianca Weinstock-Guttman. She's a professor of Neurology at Buffalo University, where her expertise regarding the Epstein Barr Virus (EBV) and her collaborative research as to how EBV relates to MS is extensive and impressive. This interview was originally recorded as part of The MS Gym's 2020 virtual Thrive Summit, which I had the honor of hosting last summer. While the rest of the world was on lockdown, we were reaching out to experts to share their knowledge in the fields of Anxiety, Telemedicine, Diet, and in this case, the EBV/MS connection. EPISODE NOTES: Elements that contribute to EBV being a trigger to MS Questioning if you have MS at all What type of virus is EBV? The focus on B cells Can EBV remain latent? EBV triggers DMTs, immunosuppression and EBV Does having had mononucleosis put you at higher risk of MS? Mononucleosis can be silent Keeping our children too clean The role of T cells Mononucleosis increases risk of MS x3 EBV reactivation Aging, immunosuppression and a higher risk of herpes zoster Is there a treatment for EBV? LINKS: Dr. Bianca Weinstock-Guttman THE MS GYM Facebook Instagram Website BROOKE SLICK Instagram Website

Talk to a Dr. Berg Keto Consultant today and get the help you need on your journey (free consultation). Call 1-540-299-1556 with your questions about Keto, Intermittent Fasting, or the use of Dr. Berg products. Consultants are available Monday through Friday from 8 AM to 10 PM EST. Saturday & Sunday from 9 AM to 6 PM EST. USA Only. Get Dr. Berg's Veggie Solution today! • Flavored (Sweetened) - https://shop.drberg.com/veggie-solution-flavored-sweetened?utm_source=Podcast&utm_medium=AGM(Anchor) • Plain (Unflavored) - https://shop.drberg.com/veggie-solution-plain?utm_source=Podcast&utm_medium=AGM(Anchor) Take Dr. Berg's Free Keto Mini-Course! In this podcast, Dr. Berg talks about the relationship between Epstein Barr Virus (EBV) and Fatigue. 90% of the population on earth has Epstein Barr Virus. Sometimes it would take 3 to 4 weeks to recover from these viruses. It has a unique strategy of inactivating our own immune system from killing it from trying to kill it. Basically, that's why it survives and it can be reactivated later in life and it's called latent infection. Epstein Barr Virus (EBV) is involved in a lot of health problems: • Hashimoto's (Autoimmune) • M.S (Autoimmune) • Non-Hodgkin's Lymphoma • Chronic Fatigue Syndrome • Fibromyalgia Symptoms of Epstein Barr Virus • Fatigue • Fever • Swollen Glands • Aches • Severe Sore Throat Dr. Eric Berg DC Bio: Dr. Berg, 51 years of age is a chiropractor who specializes in weight loss through nutritional & natural methods. His private practice is located in Alexandria, Virginia. His clients include senior officials in the U.S. government & the Justice Department, ambassadors, medical doctors, high-level executives of prominent corporations, scientists, engineers, professors, and other clients from all walks of life. He is the author of The 7 Principles of Fat Burning. FACEBOOK: fb.me/DrEricBerg?utm_source=Podcast&utm_medium=Anchor TWITTER: http://twitter.com/DrBergDC?utm_source=Podcast&utm_medium=Post&utm_campaign=Daily%20Post YOUTUBE: http://www.youtube.com/user/drericberg123?utm_source=Podcast&utm_medium=Anchor DR. BERG'S SHOP: https://shop.drberg.com/?utm_source=Podcast&utm_medium=Anchor MESSENGER: https://www.messenger.com/t/drericberg?utm_source=Podcast&utm_medium=Anchor DR. BERG'S VIDEO BLOG: https://www.drberg.com/blog?utm_source=Podcast&utm_medium=Anchor

Last week I shared some of the questions you wanted answered about Hashimoto’s. I covered topics like the relationship between heavy metals and Hashimoto’s, the role the adrenals play in Hashimoto’s, the relationship between Epstein-Barr Virus (EBV) and Hashimoto’s and how to reduce the risk for kids of people with Hashimoto’s. All of them were very important questions that have a lot to do with the triggers of Hashimoto’s. If you missed it, here is a link to episode 068.    In this episode, I answer more of your questions about Hashimoto’s.    Question #1: With Hashimoto’s, is TSH a reliable indicator of the body’s thyroid hormone needs? If not, what else can we use to know what the body needs? This can be very confusing for anyone with Hashimoto’s. The short answer is, no. TSH is not a reliable indicator. The ranges  for TSH are very broad (typically between about 4.5 - 5 depending on where you live. This range is not really optimal. The optimal range for TSH is between 1.8-3 (if you’re on thyroid medication this shifts a bit).  But, TSH is only one indicator and you need to look at the big picture including your total T4, free T4, total T3, free T3, and reverse T3. This is because TSH is not actually created in the thyroid - it's the thyroid stimulating hormone created in the pituitary gland. So, only looking at TSH doesn’t tell us which hormones the thyroid is producing and at which ratio. And, it doesn’t tell us how well the body (primarily the liver and the gut) are converting these hormones or how the hormones are actually utilized. Essentially, TSH shows a very very small part of a much bigger picture and that is why its not nearly complete. With Hashimoto’s you also want to track your antibody levels so that you can determine which triggers (listen to episode 068 for more on the four triggers) are affecting you and your levels.  I’ve listed the various tests I recommend to get the whole picture of your thyroid functionality and optimal levels for each in the show notes for episode 027. If you are looking for a lab to do these tests, here is a link to a helpful resource and lab.  I’m in the process of creating my thyroid course which is going to get way more in depth about this and how you can figure out your pattern and exactly what to do about it. The course will launch this fall. Add your name to the wait list if you’d like to be personally invited to join.    Question #2: Why does someone with Hashimoto's feel tired all day long? How can we help this and what can we do to wake up feeling refreshed and have more energy throughout the day? While Hashimoto’s is an issue, we need to look at the root cause of the fatigue. It’s true that Hashimoto’s causes the immune system to attack the thyroid and often causes hypothyroidism which has a common symptom of fatigue. So, the first step is to make sure that you are supporting thyroid function optimally with what your body needs (foods, supplements or if necessary thyroid medication that is dosed appropriately) and you are also by avoiding Hashimoto triggers (noted in last week’s episode). If you are doing these things and continue to feel tired, then you may want to consider the role your adrenal glands may be playing in your fatigue. The adrenals and the thyroid are very interrelated. Stress is a key trigger for Hashimoto’s and it can also impact adrenal function.  Clean eating is also recommended but if you continue to feel tired, you may be having some issues with absorption which could be caused by a gut issue. This could be the real cause of the fatigue as well  And finally, check that you are not deficient in nutrients that help us feel more energized like iron, B12 and other B vitamins.  As you can see, feeling tired is quite multi faceted so we have to look at it from all angles.   Question #3: My diagnosis of Hashimoto's only came after being on thyroid medication for years. Can this medication be contributing to Hashimoto's?  In my opinion, I don’t think it did. What often happens is that the Hashimoto’s is undiagnosed for many years. Conventional doctors will often stop looking for answers once they diagnose hypothyroidism. So, the Hashimoto’s may have been there or been developing all along. I don’t think that the medication could cause Hashimoto’s because whether you’re taking a synthetic hormone or a natural, desiccated hormone, you’re just replacing the hormone that the body is failing to produce. One thing that could be setting off the immune system is a sensitivity to corn. Some medications are made with cornstarch so a small amount, everyday could be causing a reaction from the immune system so that is something to look into and perhaps change to a compounded medication with no fillers can help.   Question #4: Do you have to eat after taking Levothyroxine? And, can it be taken when doing a water-fast? Levothyroxine or L-thyroxine is a T4 medication prescribed to some people with low thyroid function. It is meant to be taken on an empty stomach and you don’t need food later to help it absorb. So, in the case of a water-fast, it should not impact the effectiveness. However, water-fasts should be done under the guidance of a health practitioner so make sure they know you’re taking Levothyroxine.    Question #5: How can you lose (or gain) weight when you have Hashimoto’s I had multiple people ask me about this - both people looking to lose weight and people struggling to maintain or gain weight.  We know that the thyroid has a big effect on metabolism. Once again, it’s important to look at the full hormone picture (not just TSH levels) to determine if the thyroid is not functioning optimally. If everything looks good, then the next place to look is at the food you’re eating - specifically any foods that you may have a sensitivity to. Food sensitivities can cause inflammation resulting in water weight gain. Hormonal imbalances may also be impacting the metabolism.  The other big thing to consider is your metabolic type. We have different metabolic types, some people are protein or fat types and some are carb types. The protein types tend to do better with higher protein and fat whereas the carb types tend to do better with some carbs and less fat. If you are eating counter to your type (even if it’s super healthy) you may struggle to lose or gain weight. Also if you combine too much fat with too many carbs (even if they are good fats and good carbs) that tends to have a negative effect on our metabolism. While calories are not everything, how we combine our food does make a big difference.  For anyone struggling to maintain their weight or gain weight the first thing to check is that you’re not over medicated or over-supplemented. Next, watch for triggers that may be causing Hashimoto’s flare ups. These can send your thyroid into hyper mode and then drop back down to hypo mode. And, like the weight loss issue, make sure you are eating for your metabolic type and for you, combining good carbs with good fats would in this case be a good thing.    Question #6: Does the ketogenic diet help or hurt people with Hashimoto's? There’s a few opinions on this and it depends on how you look at it. While keto can be great for weight loss and blood sugar support as well as some neurological issues,  going on the Keto diet can be very stressful to the body - which is one of the main triggers of Hashimoto’s. It depends on your adrenal health and what your body can handle. The second thing to consider are food sensitivities. Many people with Hashimoto’s can’t do dairy but dairy plays heavily in the Keto diet. If you are unsure if dairy is an issue, do a food sensitivity test before diving into the Keto diet. Finally, consider your metabolic type. If you are a carb type, then the Keto diet (Hashimoto’s or not) is not going to be a good choice for you. Even without a food sensitivity test - trust your body. If you don’t feel good doing the Keto diet - if you feel tired and hungry - then it’s not the right approach for you.   Question #7: Do people with Hashimoto's need to stay away from iodine? If we're using  pink salt and there's no iodine, can we become deficient? In general, too much iodine is contraindicated in Hashimoto’s.  I follow Dr. Kharrazian’s research. It shows that iodine can affect TPO (thyroid peroxidase) and create more issues with Hashimoto’s. I experimented with high-doses of iodine about 12 years ago and found that it really made me feel terrible and more susceptible to colds. So, from my experience, and the research, I don’t recommend it. Having said that, we do need a small amount of iodine because it does support the thyroid but also it’s really important for breast tissue. Small doses of iodine (about 250 micrograms) should be enough to prevent deficiency but it won’t set off Hashimoto’s. For most people, this level of iodine is going to be included in a daily multivitamin. Remember that iodized table salt is processed so it’s not the healthiest way to get your iodine. It’s better to use good quality sea salt and get the necessary iodine in your multivitamin.    Eliminating Health Mysteries Do you know someone struggling with autoimmunity or Hashimoto’s? Share this episode with them. It could help them regain their health and give them hope because the answers are out there!   Links: Resources mentioned: Lab Testing: https://yourlabwork.com/innatopiler/ Suggested Products Complete Multi (with a small amount of iodine that is safe) B12 Iron   Related Podcast Episodes: Navigating the Thyroid Treatment Mystery with Inna Topiler Solving the Thyroid Mystery w/ Inna Topiler Demystifying Food Sensitivities (and What You Can do About Them) Solving the Autoimmunity Mystery w/ Inna Topiler   Thanks for Listening If you like what you heard, please rate and review this podcast. Every piece of feedback not only helps me create better shows, it helps more people find this important information. Never miss an episode -  Subscribe NOW to Health Mysteries Solved with host, Inna Topiler on Apple Podcasts, Spotify, Stitcher or Google Podcasts and remember to rate and review the show! Find out more at http://healthmysteriessolved.com   PLEASE NOTE All information, content, and material on this podcast is for informational purposes only and is not intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified physician or healthcare provider. Some of the links provided are affiliate links. This means we may make a very small amount of money should you choose to buy after clicking on them. This will in no way affect the price of the product but it helps us a tiny bit in covering our expenses.

Epstein-Barr Virus (EBV) is commonly known as mono or the kissing disease. EBV can cause a host of problems in the body, including the skin. Today's guest is here to explain all about EBV. My guest today, Dr. Kasey Holland, is a licensed Naturopathic doctor. She earned her Doctorate in Naturopathic medicine at Bastyr University in Seattle, WA through a four-year CNME accredited program. While there she completed specialty rotations in environmental medicine, immune wellness, oncology, IV therapy, Parkinson's disease, emergency medicine and mind body medicine. After this, she worked in an Integrative health clinic that incorporated functional medicine during her residency. This has provided her with exposure to a wide variety of pathologies and patient care in order to serve you better. She has always been passionate about helping people overcome mystery and chronic illnesses. This was further solidified after her own health obstacles. Dr. Kasey's specialties include the toxic trio: chronic EBV, Lyme disease, mold exposure. Join us as we talk about EBV: What it is, what causes it to reactivate, and how to get tested. Have you experienced reactivating Epstein-Barr Virus (EBV)? Let me know in the comments! In this episode: What is Epstein-Barr Virus? How and why does Epstein-Barr reactivate? Classic, and unusual, symptoms of EBV How to get tested for EBV Relationship between EBV and candida How does EBV affect the skin? Is there a link between reactivated EBV and shingles? Quotes “Epstein-Barr virus is commonly known as mono and the kissing disease. That's what we always think of it as. So, usually, you get it when you're a child, sometimes it's later in high school or college. You might not ever know that you've had it because it can be extremely mild and self-limiting.” [2:34] “When EBV is reactivated, it definitely does cause problems. No doubt about it. It has pathways that it turns on that are extremely inflammatory, that are linked to autoimmune conditions, cancers, all sorts of scary things. But hardly ever would I say that it's just Epstein-Barr virus reactivating that's leading to people with symptoms.” [5:58] Links Find Dr. Kasey online Follow Dr. Kasey on Instagram

Der nächste Teil des Themen-Monats "Co-Infektionen bei Autoimmunerkrankungen". Simone wendet sich dabei dem Epstein-Barr-Virus (EBV), Candida und Borrelien näher zu und erklärt die Zusammenhänge zu Autoimmunerkrankungen. Im zweiten Teil des Themen-Monats dreht es sich nun um Candida, einem Hefepilz, der natürlicherweise - und das ist auch vollkommen in Ordnung - im Darm existiert. Problematisch wird es aber, wenn es zu einer Überbesiedlung kommt - die tatsächlich sehr häufig mit einer Autoimmunerkrankung Hand in Hand geht. DAher wendet sich Simone heute Fragen zu wie: Was ist Candida und was kann ein unverhältnismäßiges Wachstum begünstigen? Welche Symptome sind möglich? Wie sieht eine sinnvolle Diagnostik aus? Dr. Simone Koch hat in der Autoimmunhilfe im Rahmen des Themen-Monats "Co-Infektionen bei Autoimmunerkrankungen" live auf Facebook und Instagram einen Vortrag zum Thema gehalten. Diese Podcast-Episode ist ein Mitschnitt des Videos "Candida & Autoimmunerkrankungen".

Ab und an stellt die Autoimmunhilfe einen Monat unter einen Schwerpunkt - und so gab es bei uns auch den Themen-Monat "Co-Infektionen bei Autoimmunerkrankungen". Simone hat sich dabei dem Epstein-Barr-Virus (EBV), Candida und Borrelien näher zugewandt und die Zusammenhänge zu einer Autoimmunerkrankung erklärt. Im ersten Teil des Themen-Monats hat sich Simone mit dem Epstein-Barr-Virus beschäftigt - ein Thema, was nach wie vor häufig diskutiert wird, besonders seit Anthony Williams Buchveröffentlichung. Was ist also dran, dass EBV der große (und einzige?) Auslöser für Hashimoto sein soll? Wie können EBV und Hashimoto - rein wissenschaftlich gesehen - zusammenhängen? Kann Selleriesaft wirklich helfen? Dr. Simone Koch hat im Rahmen eines Themen-Monats der Autoimmunhilfe live auf Facebook und Instagram einen Vortrag zum Thema gehalten. Diese Podcast-Episode ist ein Mitschnitt aus diesem Video des Themen-Monats: "Epstein-Barr-Virus (EBV) & Autoimmunerkrankungen". Achtung: bei ca. 12 Minuten gab es eine kleine technische Panne, leider fehlen ca. 30 Sekunden Inhalt.

TW/CW: This episode features graphic description of rectovaginal surgery, as well as discussion of suicidal ideation.   Tina Aswani Omprakash has been a Crohn’s patient for 14 years, and is the award-winning patient expert and advocate behind Own Your Crohn’s. Her aim is to normalize the rhetoric around chronic illnesses and disabilities in order to help patients own their ailments to live fuller, happier lives. Having endured multiple surgeries and overcome the stigma of her disease among family and friends, she is now pursuing a Master’s degree in Public Health at Mount Sinai’s Icahn School of Medicine. Tina is involved in IBD Social Circle and is on the Board of Advisors for the HealtheVoices 2020 advocacy conference. She also sits on the Board of Advisors for Health Advocacy Summit, the non-profit founded by former guest Sneha Dave. Tina was recently awarded the 2019 Healio Gastroenterology Disruptive Innovator Award in the Patient Voice category at the American College of Gastroenterology conference for moving the needle on GI care for patients. Via her platform of influence, she spearheads public health causes, including those proposing research for and creating awareness for inflammatory bowel disease (Crohn’s and ulcerative colitis), life-saving ostomy surgery, gastroparesis, fistulizing disease and initiatives supporting health concerns for women and racial, ethnic & sexual minorities. Tune in as Tina shares: that early on, she was additionally diagnosed with Lyme disease and Epstein-Barr Virus (EBV) that Crohn’s disease runs in her family, and was fatal for her father at the age of 39 (when she was 8) that at 21, she was diagnosed with mild ulcerative colitis — and neither given the diagnosis directly nor medicated proactive steps to take control of your health: requesting your medical records and labs, and seeking second opinions her first life-and-death experience: she developed C. diff after taking courses of antibiotics to treat contracted gastroenteritis — and had to leave work and move home the cultural stigma associated with IBD as a woman of South Asian descent that she had a 4-step J-pouch surgery after a temporary ostomy, but she developed chronic refractory pouchitis — and then went back to Wall Street that she developed her first rectovaginal fistula in 2011 — after one year of marriage how dehumanizing and desexualizing her experience has been that she has traveled to Cleveland Clinic and Mayo Clinic for treatment, and has had over 20 surgeries to-date that when trying biologics again to treat her condition, she went into anaphylactic shock — and then later, developed pyoderma gangrenosum, hidradenitis suppurativa, erythema nodosum, and Sweet’s syndrome that she spent 6 years with her J-pouch, and developed 4+ rectovaginal fistulas despite the use of biologics and follow-up surgeries that her J-pouch removal surgery was botched — by a doctor who had previously saved her life in 2008 — and as such, she was torn about pursuing a malpractice suit that follow-up surgery to correct the J-pouch issue revealed an abscess and open wound, which required more extensive long-term care her second life-and-death experience: at this stage, she was a ticking time bomb — considered septic, with a fistula growing toward her spine, and told to act fast to avoid potential paralysis that she ended up with a JP (Jackson Pratt) drain attached to her bottom and was told she’d need 3 more surgeries — and medical PTSD finally kicked in breaking point: when she became suicidal how her mom stepped up for her at her worst that she now lives with a permanent ostomy that she now has an additional diagnosis: gastroparesis (but was also diagnosed with IBS-C) that in early 2016, her Crohn’s disease went into remission how she’s navigated disagreements between different doctors on her medical team that her currently-advised diet consists largely of soup and smoothies that one of her doctors now believes she may never have had Crohn’s, but possibly had severe inflammation all along that advocacy work has become a coping mechanism for her how COVID-19 has influenced her healthcare choices how she’s experienced prejudice as a racial, ethnic, and cultural minority — both within and outside the medical system that in many ways, “coming out” with her health story 2 years ago was social suicide for her — she lost friends who couldn’t handle either her illness or her outspokenness as an advocate the role of mental healthcare in her approach to wellness how she got involved in patient advocacy

Imagine back to when you had a bad flu. Remember the nausea, head spins, pain and soreness, vomiting and diarrhea, and crushing fatigue? Remember how the worst lasted for a few days? Now imagine having that flu for a few weeks. Or a few months. Or like Jeffery Smith, for a few decades. Now think of the millions of COVID patients. A good number of the survivors are not fully recovering from this ‘flu’ bug. They remain sick for weeks. Soon they will have been sick for months. And if they are unlucky like Jeffery, they may be permanently sick and disabled, and the health care system will effectively abandon them. Most doctors didn’t take Jeff’s ongoing flu symptoms seriously, dismissing them and subtextually blaming Jeff for being emotionally weak, or not trying hard enough, or not really wanting to be healthy. You know, gaslighting. So when Jeff started to have bowel symptoms, he didn’t tell his doctor. Who needs to be invalidated and gaslighted? But it turned out Jeff had a tumour and needed surgery and suddenly the health care he received was empathic, prompt and validating. A stark contrast to the years of dismissal and gaslighting of his flu symptoms. As Jeff explains, the tumour for which he received exemplary care only impacted his quality of life a fraction compared to how the never ending flu shattered his future. And as the COVID deaths and infections continue to rise, the people who do not recover may also experience disbelieving doctors, and a health care system that doesn’t care. SHOW NOTES: 0:06:00 Jeff grew up in a small hockey town in Campbellford in Canada - and Campbellford in the 70s was more like the 50s, it was an alternate universe 0:07:00 Jeff's childhood was traumatic - he was gay living in a small town wherebody played sports or worked on the farm, where Jeff liked to watch old movies, like with Lauren Bacall, and draw their dresses - so school wasn't a safe place, and home wasn't safe because his mother had emotional issues and had a traumatic childhood, so Jeff didn't feel safe at school or home 0:08:00 Jeff didn't feel safe until he moved to Toronto for college - he was not liked by other kids because he was 'other' - but when he came to college he was suddenly popular even though he was the same person, so that was confusing and fascinating - Jeff always thought he'd not live long 0:09:00 Jeff was very sick as a child - 9 convulsions before he was 5 - doctors found Jeff had really bad allergies - they put an air conditioner in his bedroom, and Jeff felt better in the room so spent much of his time there, especially in the summer - if he went outside the heat would cause convulsions - so as a boy, Jeff got in his head he wouldn't live long 0:10:00 In grade 9 Jeff missed 3 months of school due to the flu - he started allergy shots when he was 5 years old - those helped, and the convulsions stopped 0:11:00 But in grade 9, the non-stop flu for 3 months came with fever, swollen glands, etc - when Jeff got over that and everything was okay until he got mononucleosis at age 19, during the summer 0:12:00 For 2 months Jeff couldn't really lift his head off the pillow - he had to pee in a pail beside him - it lasted 2 years of fevers, night chills - it was 1985 and the AIDS pandemic was just emerging and Jeff thought he must have AIDS, even though he'd never had sex 0:13:00 So doctors could see by Jeff's symptoms including swollen glands, that he was sick, they just didn't know why - it was rought to transition during the mono to move from home to Toronto and go to college 0:14:00 Jeff would go to school and crawl into bed after - so it was challenging, but he loved the subjects and the positive attention and learned some of his own value - Jeff remembers wondering if he had irritable bowel syndrome (IBS) because of the diarrhea, easily 10 times a day, every day for 2 years - so that meant leaving class, getting up in the middle of lunch, etc - yet trying to appear healthy and normal 0:15:00 But life was really good - trying to find a career, had lots of friends - Jeff's health was okay during this period, from 21 to 30 with okay-ish, but some bad periods with bad allergies - including missing 3 weeks one time 0:16:00 One time Jeff bought a plant, but didn't realize for weeks that that was what was making him sick - but Jeff was told my different doctors he had 'post viral malaise' - Jeff was working in a bank to earn a living 0:17:00 Then he met his partner, who would become his husband, and that's when his life really started - Jeff was 24 when they met, and Jeff was enjoying relatively good health - Jeff's allergies are anything in the environment, plants, trees, grass are the worse - he was on shots for 24 years and tested regularly 0:18:00 Jeff always scored the highest on allergy testing for grass, trees, mold, pets - Jeff lived on daily allergy pills for decades - the weather changes really affect Jeff too - so its really bad now, in the spring - it also affects his immune system 0:19:00 Jeff's immune system has been over worked since birth, so he's interested in how that realtes to mast cells - in Sept 1996 Jeff caught the flu, the regular bad flu 0:20:00 That flu has been with Jeff every day since Sept 1996 - Jeff says that if you think back to when you had the bad flu and remember how you felt - head spinning when you were not laying down, having to hold onto things - chills in your body, pain, dizzy, fatigue - fatigue so bad that you wait 20 minutes to turn over - if people can remember those feelings, and that that lasted maybe 3 days 0:21:00 Take that to 3 weeks and nothing changing, nothing getting better - then try to imagine getting up, putting on clothes while you're sweating, holding onto the sink - getting yourself to the bus, streetcar, subway, but not having the energy to stand, and having to lean - trying to make it through the work day, but not meeting your obligations, cognitively or energy wise -- now extend that 3 weeks to 3 months and you're still not better and people at work are saying your performance is down 0:22:00 And your doctor at 6 months keeps saying post viral malaise - but you can barely work, cannot watch an hour tv show - but its been 23 fucking years at that level for Jeff, with full on flu - so that's the only way Jeff can describe what happened to him in Sept 1996 0:23:00 Jeff has the same flu symptoms, some more severe, as 23 years ago - that is Jeff's reality - Jeff describes his symptoms as a constant orchestra 0:24:00 Jeff used to have good days and bad days, but now he has perhaps a few good hours each week, and the rest is bad 0:25:00 Jeff's had 3 GPs, plus lots of specialists -- but the GP at that time - 1996, pulled out a list that said 'Chronic Fatigue Syndrome' - Jeff did not have constant sore throats, but had all the other symptoms, but the doctor said that Jeff could not possibly have CFS if he did not have a sore throat 0:26:00 The doctor said Jeff had 'nerves' and some people just aren't as emotionally strong as others, and life is hard, and so what you need is a psychotherapist and a relaxation class 0:27:00 Jeff was so sick and desperate and grabbing at straws, so Jeff did therapy and relaxation classes - while they didn't help his physical health, they did help in other ways 0:28:00 But not one of them has moved his illness 1 per cent - Jeff's doctor retired, and his new GP took Jeff more seriously and sent Jeff for other testing - but there was always the overarching theory that the problem was Jeff: he was gay, overly sensitive 0:29:00 Jeff has learned through this health journey everyone wants to put you in a box - but if people had of paid attention to 'chronic fatigue syndrome' instead of calling it 'yuppie flu', he wouldn't have lost a quarter century of his life - Scott says that many people with ME (myalgic encephalomyelitis) have it develop from a flu that never went away 0:30:00 The COVID patients who do not recover are showing ME symptoms - however, it is less likely their symptoms will be dismissed with psychological bullshit because of the global onset - Jeff says from the SARS pandemic we learned that 17% of patients could not return to work at all, and 87% of not fully recovered 0:31:00 With milloins infected with COVID, without a doubt many more people will be sick with ME - COVID could be the best thing to happen to ME - there are already about 600,000 Canadians with ME 0:32:00 But there are many more people who are not diagnosed - Jeff remembers a woman from his childhood who was sick in bed for 30 years, and nobody knew why, but the narrative was that it was because she was a woman 0:33:00 Jeff feels for how this woman must have been so misunderstood for all those years - while therapy helped Jeff with his emotional life, it did nothing for his physical symptoms 0:34:00 Therapy does not stop Epstein Barr Virus from replicating in your body - even Jeff and his husband thought maybe Jeff was just really depressed but didn't know it - but every sign indicated jeff wasn't depressed - he enjoyed activities, his friends, he was optimistic - he was sick in bed and sad, sad because he was sick and in bed, not because he was sad 0:35:00 One of the elements of ME is bowel problems and IBS - in the late 2000s Jeff started to experience IBS symptoms again - but with ME, because it is multi-system, the habit is to attribute any symptom to ME, and to not tell you doctor because of the 'eye roll', as in 'here he is again' 0:36:00 Jeff got to the point where he was thinking, 'no one can help me, I don't want to be looked at as crazy, so he didn't mention it to his doctor - Jeff ignored the symptoms until he couldn't ignore them anymore - his doctor sent him for a colonscopy and they found something 0:37:00 Jeff was diagnosed with a rectal tumour and he had to have a bowel resection operation - basically they removed 95% of his rectum and he was on an ostomy bag for 6 months, but then had a 'reversal' operation and doesn't have the ostomy bag anymore - but the tumour only impacted about 20-30% as much as the ME 0:38:00 But as soon as he got that diagnosis, it was like he was in another world, another twilight zone, another life because he received help, understanding, empathy, support - it was strange compared to ME health care - Jeff really needed the reversal surgery because of the time and energy it takes to use the ostomy bag, clean, change while standing up 0:39:00 Jeff has POTS as well, so standing is a real challenge - he had a nurse for a while for the ostomy bag, but the real problem was the ME, and there was no help for that - Scott says there are 2 health systems: if you have cancer, or HIV, or a broken leg, you can usually get pretty good care - but if you have ME or something else they don't know about, you get pretty shitty care 0:40:00 When they don't have a pill or an operation, they says its in your head and they think they've cured you, they just don't want to tell somebody "I don't know' - if somebody had of said that to Jeff, his life would have changed - he wouldn't have spent 25 years beating himself up as not being good enough, not trying hard enough - Scott asks Jeff when he knew he was being gaslighted? 0:41:00 Jeff says when he saw the 'chronic fatigue syndrome' list of symptoms and he had them all except one, he figured he had it and that was in the back of his mind, but he always responded to whatever the doctors said was the problem - but the epiphany was around 2015-16 when Jeff went to Stanford chronic fatigue syndrome clinic (aka ME) in California - so 20 years after the flu started 0:42:00 When Jeff got to Stanford he first saw a nurse practitioner who had reviewed Jeff's file, the first thing she said was 'I apologize for all the medical abuse you've received from the medical community' 0:43:00 Jeff had 20 years of grief that he never expressed, because he was never told medicine made a mistake - Jeff hugged her because he didn't know what else to do - it changed his life hearing that - Jeff paid for an expensive panel of blood work - the results showed Epstain Barr Virus higher than anyone they'd ever seen at the clinic 0:44:00 For the first time Jeff forgave himself for not trying hard enough - all those years of struggling to work, only to be remprimanded for not doing well enough - Jeff took a moment to recognize that he did all that even though he was so fucking sick, and sicker today because of it - getting the blood work back showing the infections was validating 0:45:00 The layman's interpretation of what is happening, is that the Epstein Barr Virus (EBV) is replicating every 24 hours, as its been doing for 23 years - the diagnosis all made sense - the nurse started to cry too 0:46:00 Because Jeff was steadily getting worse - and this is something often not talked about, it is the people who are too sick to have a voice, literally too ill to speak 0:47:00 Jeff has periods where talking is so draining, uses so much energy - Jeff did not leave his bed for the previous 4 days, to rest up and sit up for this interview - but Jeff says he knows of so many people who are completely bed bound and cannot communicate, even on the internet - they are still there and breathing, but they don't exist otherwise 0:48:00 Severe ME has been described as like the last days of dying of AIDS or cancer - in and out of consciousness, speak very little, just like ME 0:49:00 Jeff's friend read about the Stanford chronic fatigue syndrome clinic and told him about it - Jeff took the article to his doctor, and the doctor read the article, looked up at Jeff and said 'You have myalgic encephalomyelitis' 0:50:00 At the same time, Jeff was trying to get an appointment at the Environmental Health Clinic at a Toronto hospital - it took 3 months for Jeff's Stanford appointment, but he had to wait 19 months to get the Environmental Health Clinic - the experiences were not similar 0:51:00 Jeff had to forgive himself and the medical community - like MS was called hysterical paralysis before the MRI - and we know that how people with ME are treated by the health care system causes them to kill themselves - there is no treatment, no empathy, no hope 0:52:00 And it was at that time that Jeff started advocacy, he needed to do something, in his own way with own limited abilities - Stanford started Jeff on a mitochondrial cocktail, LDN (low dose naltrexone) and valcyclovir, an antiviral 0:53:00 Jeff was only on LDN for 2 months because he was feeling sicker - it was another 3 months be bedbound because of it 0:54:00 Jeff was on the valcyclovir for 9 months, but it took away from his health, not helped - Stanford said that the chances of improving decrease the longer someone has been ill - it cost a lot for Jeff to get treatment: flights and hotels, $1200 for the appointment, another $5000 for the testing - Jeff had to cash in some of his RSPs to pay for it 0:55:00 What the Toront Enironmental Health Clinic was helpful with, was diagnosing POTS - post orthostatic tachycardia syndrome - with a tilt table test 0:56:00 For Jeff, his heart rate goes up over 30 beats a minute when he goes from laying to standing, this is why he's dizzy when he vertical - but there no real treatment for that either 0:57:00 POTS falls under cardiology, and the big thing for POTS in cardiology is exercise, but exercise makes people with ME much sicker - the cardiologist Jeff saw was part of a national board, but they excluded people with POTS and ME, because people with ME can't exercise 0:58:00 So medically marginalized again - Scott says that people who are fairly healthy wouldn't really notice a 5% improvement in their health, but if someone is sick with ME and only has 5 or 10% functioning or quality of life, a 5% improvement is huge 0:59:00 Jeff has maybe one hour a month when he doesn't feel really sick 1:00:00 Jeff feels like his body is stuck in the 'sick' position - and that relates to researcher Robert Phair's theory that people with ME's bodies are stuck in a metabolic trap, a sickness trap 1:01:00 Jeff describes his energy as 12 cents of gas a day - going to the bathroom uses 6 cents - PEM, or post exertional malaise, is the biggest issue with ME 1:02:00 For people with ME, exercise, even walking to the end of the driveway, or lifting groceries, is never going to be good, it puts energy into a deficit, and that causes PEM, an exacerbation of ME symptoms - cognitve and emotional 'effort' can also cause PEM 1:03:00 Jeff has resigned himself that he will never get better - but he thinks understanding of ME will come, and his purpose is to push that forward so that others don't have to lose decades of their lives - Jeff hopes he doesn't get so sick that he needs to be tube fed 1:04:00 Jeff's fascinated about the responses on Facebook when he posts about ME - he's educating a lot of people - having someone at the Canadian Institute for Health Research understand ME can change the world 1:05:00 Jeff has been sitting up for an hour, so the usual crushing fatigue is worse, the room is spinning - this is a lot of effort for Jeff, the equivalent of a 50 mile jog for someone healthy 1:06:00 Scott says he used to think people who did triathlons were so tough, but they have nothing on the people who live with ME - Jeff says the sickest people with ME are the toughest people you'll ever / never meet - and they are trying to help others, even when they are so sick they can't speak - Scott says he's healthier than other people with ME, maybe because of HIV meds 1:07:00 Jeff says that others with ME, who don't have HIV, can't get access to the meds because their doctors will lose their license Be a podcast patron Support Medical Error Interviews on Patreon by becoming a Patron for $2 / month for audio versions.  Premium Patrons get access to video versions of podcasts for $5 / month. Be my Guest I am always looking for guests to share their medical error experiences so we help bring awareness and make patients safer. If you are a survivor, a victim’s surviving family member, a health care worker, advocate, researcher or policy maker and you would like to share your experiences, please send me an email with a brief description:  RemediesPodcast@gmail.com    Need a Counsellor? Like me, many of my clients at Remedies Counseling have experienced the often devastating effects of medical error. If you need a counsellor for your experience with medical error, or living with a chronic illness(es), I offer online video counseling appointments. **For my health and life balance, I limit my number of counseling clients.**  Email me to learn more or book an appointment:  RemediesOnlineCounseling@gmail.com Scott Simpson:  Counsellor + Patient Advocate + (former) Triathlete I am a counsellor, patient advocate, and - before I became sick and disabled - a passionate triathlete. Work hard. Train hard. Rest hard. I have been living with HIV since 1998. I was the first person living with HIV to compete at the triathlon world championships. Thanks to research and access to medications, HIV is not a problem in my life. I have been living with ME (myalgic encephalomyelitis) since 2012, and thanks in part to medical error, it is a big problem in my life. Counseling / Research I first became aware of the ubiquitousness of medical error during a decade of community based research working with the HIV Prevention Lab at Ryerson University, where I co-authored two research papers on a counseling intervention for people living with HIV, here and here.  Patient participants would often report varying degrees of medical neglect, error and harms as part of their counseling sessions. Patient Advocacy I am co-founder of the ME patient advocacy non-profit Millions Missing Canada, and on the Executive Committee of the Interdisciplinary Canadian Collaborative Myalgic Encephalomyelitis Research Network. I am also a patient advisor for Health Quality Ontario’s Patient and Family Advisory Council, and member of Patients for Patient Safety Canada. Medical Error Interviews podcast and vidcast emerged to give voice to victims, witnesses and participants in this hidden epidemic so we can create change toward a safer health care system. My golden retriever Gladys is a constant source of love and joy. I hope to be well enough again one day to race triathlons again. Or even shovel the snow off the sidewalk.  

Eight year old Erik Johnson figured out what was making him very ill: the building his family lived in. But instead of listening to Erik, doctors gave him a psychological diagnosis - ‘maybe autism’ they said. In part 1 of my interview with Erik, he shares how he got healthy through insight into his symptom pattern, and then developing and tweaking his own treatment protocol over the following years.  Erik also exposes the federal and local cover up of infamous illness outbreaks in Nevada. Erik tells how the Centre for Disease Control CDC) essentially invented the diagnosis of ‘chronic fatigue syndrome’ to explain the flu-like outbreaks. Mix in big egos, financial interests, and sensationalist media, and that led to words and concepts being twisted so that a physical illness was downplayed, and mass hysteria up played.The CDC then became complicit in psychologizing the illness in an effort to throw more confusion around the cause of the outbreaks. Meanwhile, Erik was doing his own investigation of the outbreaks and realized that not only was there a viral aspect to ‘chronic fatigue syndrome’, but that exposure to toxic black mold - specifically Stachybotrys Chartarum - was a necessary element. Yet, in spite of Erik’s - and their own - evidence, government and medical institutions did not want to research the role of toxic mold on human health. It is far less costly - for government, for health care, for the insurance and building industries - to label sick and disabled people as fakers and fraudsters, then to face the role toxic mold has on human health, and its implication in the emergence of ‘chronic fatigue syndrome’. SHOW NOTES Autistic? 0:06:40 Erik grew up in the Sierra Nevada Mountains, about 100 miles south of Lake Tahoe on a stage coach road in an old hotel that was a historic monument, unfortunately Erik had a terrible experience with toxic mold that made Erik very sick and could not recover - pretty much everything he's done is to get better from this toxic mold 0:08:10 In 1964 his family took over management of the hotel and Erik started to get nose bleeds, fatigue, blinding headaches, rashes, neurological problems - often resembling autism - he was in and out of hospitals, saw many doctors and none could figure it out - but Erik knew by getting away from the hotel he would feel better - in the summer he'd live in the buggy barn so his room was available for guests, so every summer he was like a normal kid with lots of energy - when he moved back into the hotel in the fall, he'd get sick again 0:09:10 Erik's family and doctor attributed his symptoms to psychological problems, developmental problems, suspected autism - Erik has been on a quest to find out how many others have been affected - in 1964 he read some Mark Twain books (including Roughing It) in which he describes this illness as people from the East moving for the Western cure in California or Nevada from what was then called 'consumption' - referred to tuberculosis or any kind of wasting disease 0:10:40 Erik thinks many of the 'consumption' patients suffered from toxic mold - a Mark Twain character moved West to die, slept under the stars, started to feel better and climbed mountains - Twain quipped that 'he came West to die and made a poor job of it' 0:11:40 Erik realized when he was outside, his health improved so it was obvious to him that it was something in the hotel making him sick - when they expanded the hotel and cut through a wall that was insulated with newspapers that were covered in black mold - because the papers were so old, Erik tried to read them but completely collapsed 0:12:40 It was clear black mold was causing his symptoms - Erik was 8 years old when he figured it out - so he spent as much time outside the hotel as possible, but had to move back in for the winter months - it was devastating for him - his family moved to Lake Tahoe in the late 70s 0:13:40 But Erik experienced the same symptoms in his new school, especially the entrance - most people knew something was wrong, it was affecting a lot of teachers and students, and they learned to avoid the front entrance - Erik graduated and was still sick - turns out his school would be ground zero for the emergence of 'chronic fatigue syndrome' - a cluster of teachers with rooms near the entrance got a flu-like illness, but could not recover     Toxic Mold in the Army 0:14:40 But the other teachers also got the flu, but they recovered - only teachers also exposed to black mold remained sick - it was Truckee School - subsequently a lot of work was done to clean up the school and it feels fine now to Erik 0:15:40 Erik realized he was being affected by a specific kind of mold no matter where he went - he thought joining the army would toughen him up by going through basic training with a physical life - he also wanted the adventure and hoped maybe the military would know how to deal with mold 0:16:40 Erik was overseas in a bunker built by Hitler - in 1976 the basement armory flooded and black mold grew on the cardboard and his entire unit got sick, including a couple of fatalities 0:17:40 The symptoms were the same Erik experienced in the old hotel - one guy who had hepatitis, it was reactivated and he died - several cases of cancer - they thought the staff sargeant had brain tumours and took him out on a stretcher and they never heard of him again 0:18:40 A swine flu hit his unit and made history because they were the first nuclear missile unit to be removed from active duty due to illness - it seemed obvious to Erik that the flu compounded with black mold exposure proved devastating 0:19:40 He would sneak out of the bunker at night to sleep outside - Erik got out of the army in 1978 because he couldn't face another situation where he had no control over escaping mold - he noticed a strange illness like his, move into the San Francisco Bay area 0:20:40 People would get the flu and not recover - Erik wanted to see if there was a connection to mold so he started going to their homes or workplace and indeed Erik would react to the mold - Erik had another black mold exposure and got very sick and couldn't function at work as a hang glider instructor 0:21:40 Erik was living in an RV and it got moldy - he was forced to move back in with his family in Lake Tahoe - his mother and brother physically carried him to a doctor's office, it turned out to be Dr Paul Cheney 0:22:40 Cheney took Erik's symptoms seriously but didn't have a clue to the cause - in 1984 Cheney suggested Erik go to a big clinic in Reno for testing - at the same time the worst flu they'd ever seen hit Lake Tahoe 0:23:40 The flu was so bad it got its own name, 'the Truckee crud' because it hit the town of Truckee before Lake Tahoe and Incline Village - when people didn't recover, Dr Cheney called the CDC (Centre for Disease Control) because a group of Truckee teachers all in the same room did not recover     Sick Building Syndrome   0:24:40 Erik suggested to Dr Cheney to look into the mold - at same time another school and a casino had outbreaks, and the viral aspect was given more import and that's what Dr Cheney wanted to pursue 0:25:40 Erik went to the other locations and could feel the mold - Erik considers mold to be an important co-factor in maintaining illness - the CDC came but toxic mold had not been discovered on in the medical literature at that time - without an explanation for the sick buildings, the CDC created a new illness 0:26:40 Problem was the Tahoe flu was so severe and made so many sick as Hillary Johnson describes in her book, the local Chamber of Commerce was being whipped out, in ruins, people were so scared they refused to come to Lake Tahoe, a tourist town, dependent on the ski industry - that disappeared, 1 of 6 businesses went bankrupt 0:27:40 People cancelled reservations, and Lake Tahoe became known as ground zero for this mystery illness - the Visitor's Bureau pressured the CDC to trivialize the outbreak so the tourists would return - this is why they chose the trivializing name 'chronic fatigue syndrome' and did not include any of the immune abnormalities - the NIH (National Institutes of Health) and Dr Stephen Strauss were interested in the Lake Tahoe flu 0:28:40 NIH is National Institutes of Health and control funding for health research - when this strange illness was spreading through the US in the 80s, it reactivated Epstein Barr Virus (EBV), the 'kissing disease' - 96% of population has EBV - but testing was very crude in the 80s 0:29:40 Basically only showed if there was an elevation in EBV antibodies - Drs Peterson and Cheney used this crude test and everybody came up negative, so it looked like EBV was ruled out for the Tahoe flu - but a new test became available and Drs Peterson and Cheney re-tested and found the patients did have elevated EBV antibodies 0:30:40 They called the CDC and said we erred, the patients do have EBV - Dr Gary Holmes said if this is true, the outbreak would completely re-write the profile of EBV because its acting contagious with a short incubation period - if it has mutated, needs to be researched 0:31:40 So the CDC was investigating if there was a new form of EBV causing the outbreak - people are confused about that, thinking the CDC was called for the mystery illness, but the CDC mission was very narrow re EBV - that's why they only wanted to look at the serology reports, not examine patients     Greatest Medical Error in their entire history   0:32:40 The results were confusing because some had elevated EBV but others did not - about 2/3 were a perfect fit for EBV, but 1/3 were not - Dr Holmes left and made an off-hand remark to a newspaper reporter that they were not seeing evidence of an epidemic 0:33:40 He was referring to an EBV epidemic, but the newspapers accused Drs Peterson and Cheney of creating hysteria - Dr Cheney told the newspapers the CDC was wrong and he's stand up in a court of law and prove it - an insult to Dr Holmes 0:34:40 So Cheney is fighting for his reputation, and Holmes feels insulted and refuses to return to Lake Tahoe - so 'chronic fatigue syndrome' grew out of a mistake, a misunderstanding of what Holmes of CDC was actually saying - Holmes acknowledged that people were actually sick - Erik said Holmes is one of the most maligned people 0:35:40 because the story got around that the CDC was trying to hide the illness - but that was not there goal at the time, that emerged later, but not due to Dr Holmes, he's actually a good guy 0:36:40 About same time, Drs Peterson and Cheney sent blood to another lab and they found a new virus: HBLV - Human B-cell Lymphotropic Virus and renamed a few years later as HHV6-alpha, Human Herpes Virus 6 Alpha - an especially devastating neurotropic virus that was observed to wipe out B cells, the exact opposite of EBV 0:37:40 This explained why patients were negative on the crude test - this is described in Osler's Web, the cytopathic effect - the CDC was concerned the HHV6-alpha was causing the outbreaks - same time as emerging AIDS pandemic - 'syndrome' was a scary word, associated with AIDS - so 'chronic fatigue syndrome' didn't seem so pejorative at the time 0:38:40 'Syndrome' signified unknowns to be investigated - but it became pejorative when paired with 'chronic fatigue' - as confusion spread, the fear of a 'syndrome' dissipated - it took about 6 years 0:39:40 Then 'chronic fatigue syndrome' became identified as middle aged women who couldn't get their life together - the media is responsible for 2 things: misinterpreting Dr Holmes, and propagating a negative narrative of CFS - the Holmes definition of CFS specifically excludes psychiatric disease 0:40:40 But somehow the medical profession overlooked this - it is probably their greatest medical error in their entire history - has impacted millions of people globally     Covering up an outbreak   0:44:40 In April 1986, Dr Cheney called Erik into his office and he was very excited with Erik's test results, saying it was incredible 0:45:40 Erik was now EBV negative - but Erik was disappointed because it was thought EBV was the driving force behind CFS, and could be treated with cyclovir - so that removed Erik's option for treatment 0:46:40 Dr Cheney explained that the CDC working hypothesis was that the illness is caused by EBV and it is being reactivated by lifestyle factors, alcoholism, smoking, drugs - a wealthy Chicago entrepreneur had a daughter who was sick with the illness and he was trying to stop the CDC from blaming EBV, and Dr Cheney was looking for proof that EBV was not a factor in the illness 0:47:40 Dr Cheney wanted Erik's blood, so Erik was the first prototype for the new syndrome by using Erik's blood to demonstrate EBV was not necessary, but HHV6 was, and it is a much more scary virus - so if the CDC really wanted to clarify, they would've named it HBLV (later called HHV6) disease 0:48:30 Initially Erik didn't want to be involved, due to time and responsibility, but Dr Cheney said he had to because Erik was the only patient from original outbreak that was EBV negative and had a duty to the patient community - Erik said he couldn't because he also had a mold problem but Dr Cheney said not worry about that now 0:49:30 Erik continued to be concerned that his mold problem would corrupt Cheney's data - it then occurred to Erik that if all these clusters occurred in moldy buildings, it means mold is a critical factor in the illness, not a confounder - Erik agreed to participate on that basis 0:50:40 Erik didn't realize that no researchers would ever come back to investigate the outbreak - and the CDC was not interested in the mold / sick building factor - the CDC used the confusion to bury the Lake Tahoe outbreak, and keep it buried 0:51:40 For about 4 years the CDC wasn't sure it would work because it would just take one epidemiological researcher to find the truth - by 1992 the CDC saw the trivialization had worked perfectly so started working on their Fukuda definition of CFS to replace the Holmes definition - but why bother? The description and criteria was very similar. What was the point? 0:52:40 The point was that the Fukuda definition wasn't based on a scary outbreak that could be identified - the whole point of redefining CFS was to put distance between CFS and the initial incident it was based on to keep it in maximum confusion - and loosened up on the psychiatric exclusion, whereas Holmes was clear that psychiatric must be excluded   Part 2 of Erik's interview coming soon.   Connect with Erik Johnson:   Facebook: Erik Johnson Effect   Twitter: @ErikMoldWarrior   __________________________________________________________________________   Be a podcast patron Support Medical Error Interviews on Patreon by becoming a Patron for $2 / month for audio versions.  Premium Patrons get access to video versions of podcasts for $5 / month. Be my Guest I am always looking for guests to share their medical error experiences so we help bring awareness and make patients safer. If you are a survivor, a victim’s surviving family member, a health care worker, advocate, researcher or policy maker and you would like to share your experiences, please send me an email with a brief description:  RemediesPodcast@gmail.com  Need a Counsellor? Like me, many of my clients at Remedies Counseling have experienced the often devastating effects of medical error. If you need a counsellor for your experience with medical error, or living with a chronic illness(es), I offer online video counseling appointments. **For my health and life balance, I limit my number of counseling clients.**  Email me to learn more or book an appointment:  RemediesOnlineCounseling@gmail.com      Scott Simpson:  Counsellor + Patient Advocate + (former) Triathlete I am a counsellor, patient advocate, and - before I became sick and disabled - a passionate triathlete. Work hard. Train hard. Rest hard. I have been living with HIV since 1998. I was the first person living with HIV to compete at the triathlon world championships. Thanks to research and access to medications, HIV is not a problem in my life. I have been living with ME (myalgic encephalomyelitis) since 2012, and thanks in part to medical error, it is a big problem in my life. Counseling / Research I first became aware of the ubiquitousness of medical error during a decade of community based research working with the HIV Prevention Lab at Ryerson University, where I co-authored two research papers on a counseling intervention for people living with HIV, here and here.  Patient participants would often report varying degrees of medical neglect, error and harms as part of their counseling sessions. Patient Advocacy I am co-founder of the ME patient advocacy non-profit Millions Missing Canada, and on the Executive Committee of the Interdisciplinary Canadian Collaborative Myalgic Encephalomyelitis Research Network. I am also a patient advisor for Health Quality Ontario’s Patient and Family Advisory Council, and member of Patients for Patient Safety Canada. Medical Error Interviews podcast and vidcast emerged to give voice to victims, witnesses and participants in this hidden epidemic so we can create change toward a safer health care system. My golden retriever Gladys is a constant source of love and joy. I hope to be well enough again one day to race triathlons again. Or even shovel the snow off the sidewalk. Remedies Counseling - Making Life Better Have you had traumatic experiences with the health care system? Are you living / struggling with a chronic illness?  Do you need a counsellor with proven expertise and experience to make life better? Book an appointment with Scott online at RemediesCounseling.com RemediesOnlineCounseling@gmail.com

Are you someone that is parenting while living with a chronic condition? Raising humans while facing this type of challenge can be overwhelming.  Fatigue is a word that has plagued or ruled host Sondra Doty most of her life. In this episode she breaks down living with a chronic condition and the daily battles. She will paint the picture of walking through bouts of shame and guilt. She'll also lay out how she had to find a new pace and routine of life in managing her celiac disease and Epstein-Barr Virus (EBV).  Many who struggle in this way suffer in silence-even though it affects everyday choices, relationships (including children) and more. Sometimes, it seems easier to just internalize these struggles. But we need to learn how to talk more freely about our conditions. Share the good, the bad and the ugly. If you are living with a chronic illness you especially need to build relationships and when people are asking you how they can help you nee to have an open heart and let those people in.  Do you have questions for Word To Your Mothers Host Sondra Doty? Email wordmothers@gmail.com  Follow on Instagram & Facebook. Just search @wordtoyourmothers

Secret method discussed for inducing vulnerability in epstein barr virus. Learn how to trick epstein barr virus into exposing itself, so you can kill the EBV infected B cells.

In this episode, we are joined by Dr. Kasia Kines. Dr. Kasia Kines is an Amazon best-selling author of Epstein-Barr Virus Solution, a Doctor of Clinical Nutrition from MUIH (Maryland University of Integrative Health), and a graduate of the first doctoral functional nutrition program created by Dr. Liz Lipski, PhD and CEO of Holistic Nutrition Naturally LLC and EBV Educational Institute. She has been in clinical practice since 2005 - helping close to 2,000 clients, one at a time, with complicated health issues such as gastrointestinal and autoimmune conditions, small intestinal bacterial overgrowth (SIBO), and Epstein-Barr Virus (EBV) which is currently her main focus. Her virtual clinic serves people around the world. Because she works in depth with each individual, she takes only a limited number of new clients at a time. Dr. Kines is a compassionate clinician, taking the time to intimately know and understand every client. She spends hours of research on each client’s health history before beginning a treatment plan with them. Her countless testimonials recount from her clients are a testament to her encouraging guidance and their improved health. She continually improves her knowledge through professional organizations as well as her focused research into the maladies that affect her clients. Dr. Kines tells listeners: “You are enough as you are. You don’t have to prove anything to anybody. Just enjoy your life. Slow down and value each moment. Have more pleasure, have more joy, do things that you love.” IN THIS EPISODE, YOU WILL LEARN: What is EBV and how it differs from other viruses? Differences between acute and chronic infections  What can help prevent the reactivation of the virus? Connect with Dr. Kasia Kines : Follow Dr. Kasia Kines on Facebook, and LinkedIn Follow Dr. Kasia Kines on her website.     About Everyday Wellness Podcast Everyday Wellness is not just another health podcast. Your co-hosts, Cynthia Thurlow (nurse practitioner and functional nutritionist) and Dr. Kelly Donahue (clinical health psychologist and nutritional therapy consultant) have over 25 years of combined experience in medicine, psychology, and wellness. Our mission is to bring you the best, science-backed yet practical information to improve your physical and mental wellness every day. We are busy mom-preneurs and know how important your time is. We have designed this podcast to be short in time and big on impact. We interview a variety of guests in the field of health and wellness, and we discuss important issues and provide practical strategies that you can use in your real life.

The Case: Patti is a physically fit 42 year-old. She was experiencing fatigue, brain fog, the strangest part - exercise that used to energize her was now making her more tired. Extensive tests proved her thyroid was not to blame so we had to dig deeper in to her health history. The Investigation Despite having typical symptoms associated with hypothyroidism, Patti’s levels were well within the normal range. With that off the table, we had to really think outside the box. I started to wonder if it might be an infection or some sort of virus. That’s when I looked into Epstein-Barr Virus (EBV). According to the CDC, “ Epstein-Barr virus (EBV), also known as human herpesvirus 4, is a member of the herpes virus family. It is one of the most common human viruses. EBV is found all over the world. Most people get infected with EBV at some point in their lives. EBV spreads most commonly through bodily fluids, primarily saliva. EBV can cause infectious mononucleosis, also called mono, and other illnesses.” It’s estimated that 90% of the population are infected with EBV at some point in there life. There’s no medical treatment but there are some natural health options that can speed up recovery. One of the leaders in developing a natural approach to EBV is Dr. Kasia Kines. Kasia is a Doctor of Clinical Nutrition and the CEO of EBV Educational Institute and Holistic Nutrition Naturally. She’s also the author of the Amazon best-seller The Epstein-Barr Virus Solution. She joins me on the show to discuss the symptoms and solutions for this very common problem. It’s a Global Issue This virus has been around for a long time and scientists have been searching for a vaccination since it’s discovery. Nothing has been found. Most Doctors Completely Dismiss EBV Despite the virus being very well known, many conventional doctors miss the symptoms. Some doctors don’t even want to test the blood for EBV markers. Symptoms Range Greatly In an acute episode, symptoms can resemble a really bad flu including feeling achy, swollen lymph nodes, and scratchy throat. This is the typical presentation of ‘mono’. At a chronic level, the symptoms could be fatigue, exercise intolerance, brain fog, hypersensitivity to mosquito bites, and can even develop into autoimmune diseases like arthritis, Crohn’s, or Hashimoto’s. There are Four Antibodies to Look For Once you get the right labs (blood tests) you can use this graph (from Dr. Kines’ website) to determine what your lab results indicate.   Even After Recovering from Mono, the Virus Can Hang Around While you may feel fully recovered from ‘mono, the virus can stick around. It doesn’t live in the bloodstream, it only comes into the bloodstream when it reactivates (usually when the immune system is challenged). If the virus is not taken care of, it can go deeper into the organs, tissues, joints, and even the brain. MYTH: EBV is Not Treatable Many doctors believe that nothing can be done about acute or chronic EBV. But, this is not true. It is reversible with nutrition modification, environmental toxins exposure reduction, and a lifestyle shift away from stress. This is key because the virus really responds to stress hormones. In addition, specific supplements have proven helpful (see below) and in some cases, reducing exercise may also speed up the recovery process. Eliminating Health Mysteries For Patti we were able to identify the underlying issue behind her health mystery. Patti reduced her usual workout to very light exercise, shifted her diet, got a lot more rest, and took additional supplements to support fighting the virus. After 3 months, she felt a lot better. Could this be the missing clue for you or someone in your life? Remember, the presentation of EBV is very individual. If you suspect this might be what’s behind your unexplained health issues, it’s worth exploring. Note that if you follow the EBV protocol, you should notice a change in a couple of weeks. If you don’t, then this might not be the answer to your particular mystery. Resource Links: Resources and products mentioned on the podcast: N-Acetyl Cysteine (NAC) L-Lysine Selenium Zinc Thanks to my guest Dr. Kasia Kines. You can connect with her on Facebook or via her website. Here is where you can find her book The Epstein-Barr Solution.    Thanks for Listening If you like what you heard, please rate and review this podcast. Every piece of feedback not only helps me create better shows, it helps more people find this important information. Never miss an episode –  Subscribe NOW to Health Mysteries Solved with host, Inna Topiler on Apple Podcasts, Spotify,  or Stitcher. Say hi to me on Facebook and Instagram. Comment on this episode and let me know if it helped. Or at http://healthmysteriessolved.com   Overcoming Hashimoto’s Summit Claim your free spot to this 7-day virtual summit featuring the top experts in Hashimoto’s and Hypothyroidism so that you can overcome this diagnosis and feel better. https://bit.ly/2KigemW     PLEASE NOTE All information, content, and material on this podcast is for informational purposes only and is not intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified physician or healthcare provider.  

Zahra Bergmann hat in Deutschland Medizin studiert. Der Hintergrund war, dass sie sich selbst mit den Erkenntnissen aus dem Studium von einer chronischen Krankheit heilen wollte. Leider musste sie dabei feststellen, dass die Schulmedizin ihr nicht helfen konnte. Sie suchte nach Alternativen und stieß dabei auf die Rohkost-Enährung, insbesonder auf das Wissen des Rohkost-Pioniers Dr. Norman Walker (Bestsellerautor von "Frisch gepresste Säfte" und "Auch Sie können jünger werden"). Im Laufe der Jahre setzte sie sich immer tiefer mit Alternativtherapien auseinander, z.B. mit der Temperamentenlehre. Infos und Protokolle von der Ärztin Zahra Bergmann unter: https://germanygoesraw.de/rohkost-arzt/aerztin-zahra-bergmann/

Dr. Kasia Kines joins us this week as we are digging into Epstein Barr Virus (EBV) and fertility. Dr. Kasia Kines is a Doctor of Clinical Nutrition, the CEO of Holistic Nutrition Naturally and EBV Educational Institute. She is a Board-Certified Nutrition Specialist, Certified Nutritionist licensed by the Washington State, with two Master’s degrees, including a Master’s in Clinical Nutrition, form the prestigious Bastyr University. She is the author of the Amazon best-selling book The Epstein-Barr Virus Solution. Dr. Kines has been in clinical practice since 2005, providing individualized support to nearly 2,000 clients with complicated health issues, with EBV now being her main focus. Her virtual practice serves clients nationally and globally. Her book is available on amazon - Epstein-Barr Virus Solution: https://www.amazon.com/Epstein-Barr-Solution-Undiagnosed-Destroying-Autoimmune-ebook/dp/B07G3ZVHG1/ref=sr_1_3?ie=UTF8&qid=1533332818&sr=8-3&keywords=EBV+book -- Visit her website: https://kasiakines.com/ -- Download your two (2) FREE gifts here: https://ebvhelp.com/gift-for-readers/ enter 55555 into the receipt area to gain access. -- Book your Free Supercharge Your Fertility Discovery Call here: https://intakeq.com/booking/cZ7XW6 -- Download your free fertility yoga video. In this 20-minute intro video, we focus on a calming and peaceful practice to connect back to our heart. These simple yoga poses can help quiet negative thoughts and make you feel more in control. www.yogafreebie.com   -- Don't forget to check out my Resources page for more information and products that will help you on your fertility journey.

Epstein-Barr Virus (EBV) is one of the eight known herpes viruses. While it’s one of the most common human viruses on the planet, and while most carriers do not have symptoms, others will experience devastating health consequences. Dr. Kasia Kines helps us understand why. November 2, 2018 > Click here to download the completed Matrix from this week’s episode > Click here to get Dr. Kasia Kines’ invaluable book ‘The Epstein-Barr Virus Solution’ > To go to Dr. Kines’ website for more on EBV testing, click here   Get 15-Minute Matrix podcast notifications delivered to your inbox!

Scott's site: http://betterhealthguy.com TFIM: https://forumforintegrativemedicine.org LymeLight: http://lymelightfoundation.org Lyme Disease http://learntruehealth.com/lyme-disease-scott-forsgren So many people have Lyme disease. But because the symptoms are not initially apparent, it takes time, and a lot of testing before it gets diagnosed. My guest Scott Forsgren is no stranger to this disease, and he’ll tell us how he survived Lyme disease in this episode. Scott Forsgren is a health coach, podcaster, and health advocate who took years to recover from Lyme disease. He says Lyme disease can be a complex and challenging condition for people. And the more broadly that we cast the net, the more potential we have to optimize health and wellness. Early Signs Scott Forsgren shares that his journey started 22 years ago when he had a tick bite in Northern California in 1996. But he didn’t think anything of it at the time because Lyme disease wasn’t something anyone talked about back then. There was very little information available. “So, I did find for several months, around April 1997, that I had the flu on steroids. It was a tremendous sickness over several days. Those symptoms continued for several more months. And I wasn’t sure if I’d even survive that experience,” recalls Scott Forsgren. Every system of Scott Forsgren’s body was affected. He had vision problems, fevers, joint pain, muscle pain, lots of gastrointestinal problems, cognitive issues regarding brain fog, and memory loss. There were also episodes of numbness and tingling, tapping sensation in his left foot, tremors, internal vibration, muscle twitches. A lot of these conditions can also lead to anxiety and depression and obsessive-compulsive behavior. Finding A Cure From 1997 to 2005, Scott Forsgren saw about 45 different practitioners. The majority suggested that it was all psychological and that he should work with a psychologist or psychiatrist. Scott Forsgren did get a diagnosis of chronic fatigue syndrome and fibromyalgia. He even had a doctor who suggested multiple sclerosis. “I did work with a fantastic medical doctor in Arizona. There were a few years was good. Then in 2004 all of the symptoms came back,” said Scott Forsgren. “I do think Lyme is a worldwide problem. When someone has Lyme, there’s more than just Lyme disease that we need to look at to maximize the potential for our recovery.”  Starting Over Scott Forsgren went over to the American College for the Advancement of Medicine and looked for a new functional medicine doctor. He wanted someone that was Holistic and who would look broadly at all the potential issues. He was then referred to an acupuncturist who worked in an outlet mall that was doing computer-based energetic testing. Scott Forsgren recalls that the acupuncturist advised him to have a doctor to test him for borrelia or spirochaete. Furthermore, Scott Forsgren was also encouraged to see if there were some food that might be stressing his body. Turning Into A Believer Scott Forsgren was a skeptic, but when he got himself tested, everything the acupuncturist said was right. That piqued his interest in this realm of energy testing. Over the years, acupuncture became his number one tool to guide my journey back to wellness. “So, one of the important things is to keep an open mind. A lot of things that I would not have been open to 20 years ago when this whole journey started are the things that I ultimately now have found to be the most beneficial,” said Scott Forsgren.  After Scott Forsgren got officially diagnosed with Lyme disease, he also started learning from Dr. Dietrich Klinghardt. Dr. Dietrich Klinghardt has a system of energetic testing that Scott Forsgren learned over the years as well as utilized and benefited from. He also did work with Dr. Klinghardt as a patient. And according to Scott Forsgren, that was the best decision he ever made overall in his health journey. Autonomic Response Testing Autonomic Response Testing (APT) is a system of muscle testing. But Scott Forsgren says there is no perfect system. He says we use these systems to uncover information and get us closer to the truth.  It’s also a way to understand the things that are stressing the body that may need some support. Scott Forsgren believes some of us have less than optimal detoxification capacity to even end up with the condition that is related to Lyme disease and many others. But they may not manifest symptoms at all. “I do think that one’s detoxification capacity plays a significant role concerning symptoms that we develop. Dr. Dietrich Klinghardt either suspects or believes that probably everyone has been exposed to some Lyme related organisms at some point during their lifetime,” Scott Forsgren said.  He adds,” I think genes do not tell the entire story, but I think epigenetics does. It influences our genetic expression. We change how our genes express through stress management, nutrition, detoxification and joy in our life.” Scott Forsgren also reveals that most people who are dealing with Lyme disease very type A+ personalities and perfectionists. So, he thinks there are aspects of certain characters that are always in that sympathetic dominant mode. Key Things To Regain Balance First is removing the impact of negative emotions, thought patterns, emotional traumas, and conflicts. Scott Forsgren also advises looking at your environment. Do mold or biotoxin exposures surround you daily? Because that’s one of the critical causes of harmful exposures. Scott Forsgren also advises to look at nutrition and gut health as well as explore detoxification. He says we need to create an environment that is supportive of our healing. “Look for parasites and other microbial overgrowths whether it’s Lyme, co-infections or fungal issues like yeast. Viruses can play a big role as well,” said Scott Forsgren. “Also explore dental contributors like amalgam fillings, root canals or cavities. Rewire the limbic system which is part of the brain that includes the hypothalamus.” Limbic System The limbic system is called the feeling and reacting brain. Scott Forsgren says it is involved in determining our level of safety regarding the things that we might encounter, smell, see, hear and taste. Scott Forsgren explains that you can think of it as the alarm center and anxiety switch. It influences the functioning of our immune system, hormonal system, endocrine system, autonomic nervous system. Ultimately, it is involved in blood pressure, heart rate, breathing and digesting. Any of these things can trigger a limbic system impairment. “If someone doesn’t resonate with having had emotional trauma or conflict that set the stage for their condition, it creates a trauma which we need to process in some way,” said Scott Forsgren. Using Saunas Saunas are good, but Scott Forsgren says some people may not entirely be ready for it. We can mobilize some toxins internally as well. So we have to make sure the routes of elimination are open. “When you use a sauna, you do sweat things out, but at the same time, you can mobilize some toxins internally. A sauna is a good tool, but you need to listen to your body and not force something that maybe they’re not quite ready for,” said Scott Forsgren. “Detoxification is a life-long focus. I do it every day.”  He adds, “When we’re recovering from a chronic condition like Lyme disease or mold exposure, detoxification is critical. Microbes like candida and parasites may be present in the body because the body is utilizing them or allowing them to be there to concentrate heavy metals, to help us detoxify. So not all of these organisms are necessarily bad or that we need to get rid of.”  Testing For Molds If someone is not recovering from chronic Lyme disease despite doing all the right things, Scott Forsgren advises that they have to explore the mold piece. He urges everyone who is suffering from Lyme disease, making sure that your environment is safe from a mold perspective and an EMF perspective. Because bottom line, you want to create a sanctuary for recovery. “About 25% of the population has a genetic predisposition to illness from water-damaged buildings. And similar to Lyme disease, there is no perfect test for molds, so it’s critical for people to explore,” said Scott Forsgren.  Starting with your home, Scott Forsgren says any place where you spend time on a regular basis should be suspect until you explored it. And then if an issue is identified, you may be able to do some remedies like moving to a new environment. Putting in some good air filtration device in the environment is also very helpful. It’s not a solution to a problem, but it’s something that can fix the situation while you are addressing the core issue. ISEAI International Society for Environmentally Acquired Illness (ISEAI) is an organization that has come together reasonably recently with doctors that deal with biotoxin illnesses. Some environmental professionals are part of this organization as well. According to Scott Forsgren, the organization is an excellent resource if you dive deeper into learning the cause of illnesses. The ISEAI website states that it is a nonprofit professional medical society whose aim is to raise awareness of the environmental causes of inflammatory illnesses.  They also support the recovery of people affected by these illnesses using an integration of clinical practice, education, and research. Better Health Guy Website The website started in 2005 before Scott Forsgren had the Lyme disease diagnosis. Three months after the site launched, Lyme disease became the focus of the site. “The most interesting area for people to check out is the podcast where I interview experts as well as articles he has written over the years. Part of what’s on the blog are notes from different conferences that I have attended over the past ten plus years,” said Scott Forsgren. LymeLight Foundation Another organization that Scott Forsgren wanted to highlight was the LymeLight Foundation. The LymeLight Foundation is an organization that provides treatment grants to children and young adults 25 and under for Lyme disease treatments. “I think it’s critical for people to maintain hope. There are so many things that have improved in our understanding of Lyme disease and chronic conditions over the last several years,” said Scott Forsgren. He adds, “Lyme disease is a messenger for many of us. And the process of going through it is life changing. While it is the biggest challenge that many will ever face, something beautiful often happens as a result of the experience.”  Bio Scott Forsgren, FDN-P is a health coach, blogger, podcaster, health writer, and advocate. He is the editor and founder of BetterHealthGuy.com, where he shares his 21-year journey through the world of Lyme disease, mold illness, and the myriad of factors that chronic illness often entails. Scott Forsgren’s podcast “BetterHealthGuy Blogcast” interviews many of the leaders in the field and is available on his website, BetterHealthGuy.com, and on YouTube, iTunes, Google Play, Stitcher, and Spotify. He has been interviewed on numerous podcasts and has lectured on his recovery from chronic illness as an invited speaker of the Klinghardt Academy, at AutismOne, and on three Chronic Lyme Disease Summits.  Scott Forsgren has written for the Townsend Letter and other publications. He is the co-founder of The Forum for Integrative Medicine which hosts an annual conference bringing together some of the top integrative practitioners to share practical tools for treating complex, chronic illness.  He serves on the Board of Directors of LymeLight Foundation which provides treatment grants to children and young adults recovering from Lyme disease. Today, Scott Forsgren is grateful for his current state of health and all that he has learned on this life-changing journey. 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Dr. Kasia Kines is a Doctor of Clinical Nutrition and the CEO of Holistic Nutrition Naturally and EBV Educational Institute. She is a Board-Certified Nutrition Specialist and is the author of the Amazon best-selling book The Epstein-Barr Virus Solution. Dr. Kines also trains practitioners in EBV through an online clinician track program. In this episode, we talk about the relationship between Epstein-Barr Virus (EBV), cancer, chronic fatigue, and autoimmune disorders, how your environment plays such an important role in managing EBV, what to look out for in EBV testing and diagnosis, Kasia’s top three solutions for managing EBV, and so much more!   To learn more about Dr. Kasia Kines, visit the show notes.

The Herpes Virus family consist of a number of viruses--herpes simplex-1 and 2, cytomegalovirus (CMV), Varicella Zoster Virus (VSV) and Epstein-Barr Virus (EBV). EBV infects about nine out of 10 people and a good number will develop infectious mononucleosis (IM) Despite this, my guest today, infectious disease physician, Steven LaRosa, MD calls EBV "The red-headed step child of the Herpes Virus family". Dr LaRosa talks about signs and symptoms, pathology and more. In addition, he looks at the association between multiple sclerosis (MS) and EBV and the association of EBV with numerous auto-immune diseases.

There's an infection that I’ve been seeing more in my practice: Epstein-Barr Virus (EBV). Today I'm talking about the link between EBV and Hashimoto's. "Times of stress, fatigue, and going through major life changes, even for example big hormonal changes like perimenopause, can cause us to be particularly susceptible to new infection, reactivation of the virus, and then getting symptomatic." - Aviva Romm Join Dr. Aviva Romm as she dishes up a weekly dose of the whole truth on health and medicine. To learn more about this episode of Natural MD Radio go to http://www.avivaromm.com/047.

Formine spielen eine wichtige Bedeutung bei der Regulierung polarisierter Aktin-gesteuerter Prozesse. Dies betrifft beispielsweise die Zellmigration, den Vesikeltransport, die Morphogenese und die Zytokinese (Faix und Grosse 2006). In früheren Arbeiten konnte nachgewiesen werden, dass das Protein Formin-like 1 (FMNL1) in Zellen von Patienten mit chronischer lymphatischer Leukämie (CLL), anderen Leukämien und Lymphomen und in Zelllinien, die von soliden Tumoren stammen, überexprimiert wird. Im gesunden Gewebe wird es fast ausschließlich in hämatopoetischen Zellen exprimiert. Diese selektive Expression macht FMNL1 zu einem attraktiven Ziel für neuartige Immuntherapien bei malignen und entzündlichen Erkrankungen (Krackhardt, Witzens et al. 2002; Schuster, Busch et al. 2007). In Vorarbeiten der Gruppe wurde ein allorestringierter T-Zellklon mit einem definierten T-Zellrezeptor identifiziert, der ein Peptid von FMNL1 erkennt und eine starke Antitumor-Aktivität gegen Lymphom- und Nierenzellkarzinom-Zelllinien, Epstein-Barr-Virus (EBV)-transformierte B-Zellen und von CLL-Zellen zeigt (Schuster, Busch et al. 2007). Allerdings sind die Funktion und Regulation von FMNL1 – beide wichtig für die Validierung dieses Proteins als Antigen – noch nicht gut untersucht. Frühere Arbeiten haben eine Beteiligung von FMNL1 bei der Neuausrichtung des MTOC (Mikrotubulin-organisierendes Zentrum) in Richtung der immunologischen Synapse und zusätzlich bei der Zytotoxizität von T-Zellen beschrieben (Gomez, Kumar et al gezeigt. 2007). Darüber hinaus wurde gezeigt, dass das murine FRL, das zu 85% homolog zum menschlichen FMNL1 ist, an der Zelladhäsion und Motilität von Makrophagen sowie an der Fc-Rezeptor-vermittelten Phagozytose beteiligt ist (Yayoshi-Yamamoto, et al Taniuchi hat. 2000; Seth, Otomo et al. 2006). Das Ziel dieses Projekts war es, die Funktion von FMNL1 für die weitere Validierung dieses Proteins als mögliche Zielscheibe für neue Anti-Tumor-Therapien zu untersuchen. Wir haben eine neue Spleißvariante (FMNL1) identifiziert, die am C-terminalen Ende ein residuelles Intron aufweist, welches einen Einfluss auf die Diaphanous-autoinhibierende-Domäne (DAD) hat. Im Gegensatz zu anderen FMNL1-Spleißvarianten, die eine zytoplasmatischen Lokalisierung aufweisen, zeigt diese Speißvariante eine kortikale und membranständige Lokalisation in verschiedenen Zelllinien. Eine FMNL1 Mutante, bei der die DAD-Domäne fehlt (FMNL1ΔDAD), weist eine ähnliche Lokalisierung auf. Das weist darauf hin, dass es bei FMNL1 zu einer Deregulierung der Autoinhibition kommt, die zu einer konstitutiv aktiven Form von FMNL1 führt, die möglicherweise bei der zellulären Transformation eine Rolle spielen könnte. FMNL1 und FMNL1ΔDAD können eine polarisierte, nicht mit einer Apoptose-assoziierten Blasenbildung an der Membran hervorrufen, die von Myosin, Aktin undTubulin abhängig ist, aber unabhängig von Src und ROCK zu sein scheint. Wir haben außerdem nachgewiesen, dass FMNL1 als myristoyliertes Protein vorliegt und konnten zeigen, dass die N-terminale Myristoylierung wichtig für die Regulierung der Funktion von FMNL1 ist, indem sie eine schnelle und reversible Membran-Lokalisierung ermöglicht. Des Weiteren haben wir gezeigt, dass FMNL1, das auch am kontraktilen Ring und Kortex von FMNL1-transfizierten mitotischen Zellen lokalsiert ist, die Zellproliferation moderat verstärkt. Eine gemeinsame Lokalisierung von menschlichem endogenem FMNL1 und -Tubulin am Kortex und den mitotischenden Spindeln von sich teilenden T-Zellen weist ebenfalls auf eine Rolle von FMNL1 in der Mitose und dem Zellwachstum hin. Überexpression von FMNL1 konnte eine höhere Konzentration von intrazellulärem freiem Calcium nach Zell-Stimulation induzieren, was auf eine Beteiligung von FMNL1 am Calcium-Signalweg deutet. Unsere Ergebnisse eröffnen neue Einblicke in die Regulation und Funktion von FMNL1 und zeigen dessen Beteiligung an unterschiedlichen Polarisierungsprozessen. Die Identifizierung von Interaktionspartnern von FMNL1 in verschiedenen hämatopoetischen Zellen sowie die weitere funktionelle Charakterisierung der Spleißvarianten wird von besonderer Bedeutung sein, und möglicherweise zur Entwicklung einer spezifischen therapeutischen Beinflussung maligner und entzündlicher Erkrankungen beitragen.

Das Membranprotein LMP1 des Epstein-Barr Virus (EBV) stellt das primäre Onkogen des Virus dar. Es ist essentiell für eine effiziente Transformation von B-Zellen durch das Virus und ist allein ausreichend, um Nagerfibroblasten zu transformieren. LMP1 aktiviert eine Vielzahl von Signalwegen über zwei carboxyterminale Aktivierungsregionen (CTAR1 und CTAR2), unter anderem die JNK-, die NF-κB, die PI3K- und die Jak/STAT-Signalkaskaden. Die Aufklärung der Signaltransduktion von LMP1 auf molekularer Ebene ist der Fokus intensiver wissenschaftlicher Forschung. Ziel der vorliegenden Doktorarbeit war es, neue Interaktionspartner von LMP1 zu identifizieren und so Lücken zwischen LMP1 und den weiter stromabwärts liegenden Signalwegen zu schließen. Dazu wurde im ersten Teil der Arbeit eine Methodik entwickelt, mit dem der Signalkomplex von LMP1 massenspektrometrisch untersucht werden konnte. Hierzu wurde zunächst ein Zellsystem etabliert, mit dem der LMP1-Multiproteinkomplex aus lymphoblastoiden Zelllinien (LCLs), also im viralen Kontext, präzipitiert werden konnte. Darüber hinaus wurde ein zusätzlicher Aufreinigungsschritt durch die Integration einer TEV-Protease-Schnittstelle zwischen den Transmembrandomänen und dem C-Terminus von LMP1 eingeführt. Mit diesem Verfahren wurde eine Reihe von neuen potenziellen Interaktionspartnern von LMP1 identifiziert. Von diesen konnten bereits zwei Proteine als LMP1 Interaktionspartner mit weiteren Methoden verifiziert werden, das Transmembranprotein CD48 und die Kinase TNIK. Der zweite Teil der Arbeit beleuchtet die Rolle der Protein-Tyrosin-Phosphatase SHP-1 in der Signaltransduktion von LMP1. Sie wurde in unserer Arbeitsgruppe als Interaktionskandidat von LMP1 identifiziert. Neben der Verifikation der Bindung gelang es in dieser Arbeit, die Interaktionsstelle von SHP-1 auf die beiden Tyrosine Y185 und Y186 von LMP1 zu kartieren. Damit wurde neben CTAR1 und CTAR2 ein weiteres, neues Bindemotiv von LMP1 entdeckt. Es konnte im Rahmen dieser Doktorarbeit gezeigt werden, dass LMP1 den NF-κB- und den Jak/STAT-Signalweg nicht nur induziert sondern durch die Interaktion von LMP1 mit SHP-1 diese Aktivierung regu-liert und begrenzt. LMP1 verfügt somit auch direkt auf der Ebene der Signaltransduktion über einen Me-chanismus, der seine eigene Aktivität moduliert.

Die adoptive T-Zelltherapie ist eine attraktive Alternative zu konventionellen Therapien zur Behandlung von malignen Erkrankungen. So konnten bereits Tumorremissionen bei Melanompatienten nach adoptivem T-Zelltransfer erreicht werden (Dudley et al, 2002b; Morgan et al, 2006). Während im autologen System jedoch oft nur unzureichende Antitumorantworten zu generieren sind, zeigt der Erfolg der allogenen Stammzelltransplantation, dass im allogenen System T-Zellen hoch effektiv Tumorzellen bekämpfen können. Die allogene Stammzelltransplantation konnte auch bei B-Zell-Non-Hodgkin-Lymphomen, wie beispielsweise der chronischen lymphatischen Leukämie (CLL), mit Hilfe eines Transplantat-gegen-Leukämie-Effektes (Graft-versus-Leukemia, GvL) lang andauerndes, krankheitsfreies Überleben bewirken. Sie birgt aber ein sehr hohes Morbiditäts- und Mortalitätsrisiko auf Grund der Transplantat-gegen-Wirts-Erkrankung (Graft-versus-Host-Disease, GvHD) in sich. Die im Transplantat enthaltenen T Zellen sind hierbei sowohl für den erwünschten GvL-Effekt verantwortlich, gleichzeitig aber auch für die unerwünschte GvHD (Horowitz et al, 1990; Kolb et al, 2004). Zur Minimierung des Risikos einer GvHD könnten T Zellen eingesetzt werden, die spezifisch und allorestringiert Peptide von tumorspezifischen Antigenen erkennen und somit bevorzugt Tumorzellen angreifen. Die Reaktivität der T Zellen kann durch einen T Zellrezeptor (TZR)-Transfer auf sekundäre Zellen übertragen werden. Diese transgenen Zellen können dann mittels adoptivem T Zelltransfer im Patienten zur selektiven Bekämpfung von Tumorzellen zum Einsatz kommen. In Vorarbeiten wurde FMNL1 (formin related protein in leukocytes 1) als hoch attraktives tumorassoziiertes Antigen identifiziert, das in der chronischen lymphatischen Leukämie (CLL) und in anderen Lymphomen, sowie in Zelllinien solider Tumoren stark überexprimiert wird, während es in gesunden Zellen fast ausschließlich in hämatopoetischen Zellen vorkommt. Ziel der vorliegenden Arbeit war es, allorestringierte FMNL1-peptidspezifische T-Zellen zu isolieren, zu charakterisieren und den T-Zellrezeptor dieser T-Zellen in sekundäre Zellen zu transduzieren. Hierzu wurden Peptide des tumorassoziierten Antigens FMNL1 mit Hilfe von Prädiktionsalgorithmen vorhergesagt und in T Zell-Stimulationsansätzen eingesetzt. Unter Einsatz von HLA-A2-positiven T2-Zellen als antigenpräsentierende Zellen, die mit dem prädizierten synthetischen Peptid FMNL1-PP2 beladen waren, ist es gelungen allorestringierte, FMNL1-PP2-spezifische T Zellen eines gesunden HLA-A2-negativen Spenders zu isolieren. Von 67 T-Zellklonen bzw. oligoklonalen T-Zellen konnte bei neun T-Zellklonen Allorestriktion und FMNL1-PP2-Peptidspezifität nachgewiesen werden. Der T-Zellklon SK22 war für diese neun T-Zellklone, die auf Sequenzebene einen identischen T-Zellrezeptor aufwiesen, repräsentativ. Der T-Zellklon SK22 zeigte in Reaktion auf peptidbeladene T2-Zellen eine hohe Peptidspezifität für FMNL1-PP2 im Kontext mit dem für SK22 allogenen HLA-A2. Nach Zielzellerkennung sezernierte der T-Zellklon Zytokine wie IFNγ, TNFα, GM-CSF und teilweise IL2. Der T Zellklon zeigte eine hohe Aktivität und mittlere Avidität gegen FMNL1 PP2-beladene T2-Zellen. Des Weiteren wurde die Reaktivität gegen unbeladene native Zellen getestet. Der T-Zellklon SK22 erkannte verschiedene Zellen, wenn sie HLA-A2-positiv waren und gleichzeitig FMNL1 exprimierten. Hierzu zählten zum einen maligne Zellen, darunter verschiedene Epstein-Barr-Virus (EBV)-positive und EBV-negative Lymphomzelllinien und die Nierenzellkarzinomzelllinie RCC26, die gut erkannt wurden sowie CD40-aktivierte CLL-Zellen, die schwächer erkannt wurden. Bei der Untersuchung von gesundem Gewebe wurden FMNL1-exprimierende HLA-A2-positive periphere Blutleukozyten (PBL) schwach und B-Zellen in mittlerer Stärke erkannt. HLA-A2-positive Zellen, die FMNL1 nicht exprimieren, wie beispielsweise Lungenfibroblasten, wurden vom T-Zellklon SK22 nicht erkannt. Der T Zellklon zeigte Kreuzreaktivität gegen neun verschiedene lymphoblastoide Zelllinien (LCL), die Allelvarianten von HLA-A2 exprimierten. Zusätzlich wurden 4 von 18 HLA-A2-negativen LCL-Zelllinien erkannt. Jeweils zwei dieser vom T Zellklon SK22 erkannten HLA-A2-negativen LCL-Zelllinien trugen ein gemeinsames MHC-Klasse-I-Molekül. Eines davon war HLA-A*3303, welches durch die Erkennung der HLA-A*3303-positiven Transfektante der C1R-Zelllinie bestätigt werden konnte. Das andere war HLA-A*6802, welches zur HLA-A2-Superfamilie gehört. Der T-Zellrezeptor des T-Zellklons SK22 wurde identifiziert, sequenziert und kloniert, sowie mit Hilfe von Retroviren in sekundäre Zellen eingebracht. Durch den Transfer des T Zellrezeptors von SK22 in sekundäre Zellen konnte nachgewiesen werden, dass dieser T Zellrezeptor für die spezifische Reaktivität des T-Zellklons SK22 verantwortlich war. Dies zeigte sich in der T-Zellrezeptor-Oberflächenexpression nach Transduktion in Jurkat76-CD8α-Zellen und in der Übertragung der Funktionalität des T-Zellklons in PBL. Der T Zellrezeptor von SK22 ist ein „schwacher“ Rezeptor, da er in der Konkurrenzsituation mit einem weiteren Rezeptor nur in geringem Grade an der Zelloberfläche von PBL exprimiert wurde. Durch einen Austausch der jeweiligen konstanten Regionen der T-Zellrezeptor-SK22-Sequenzen durch die konstanten Bereiche eines murinen T-Zellrezeptors konnten in der Summe verbesserte Expressionswerte in Jurkat76-Zellen und eine verbesserte Funktionalität in PBL erreicht werden. Der T-Zellklon SK22 zeigte Allorestriktion, FMNL1-PP2-Peptidspezifität und Zytotoxizität gegen FMNL1-exprimierende Zellen, insbesondere gegen Tumorzellen. Die beobachtete Kreuzreaktivität ist Fokus weiterführender Untersuchungen. Im Fall des T-Zellrezeptors von SK22 bedeutet es, dass Spender und Patienten sorgfältig nach Analyse des gesamten MHC-Klasse-I-Expressionsmuster ausgewählt werden müssen. Im Rahmen einer haploidentischen Stammzelltransplantation ist jedoch der klinische Einsatz dieses spezifischen T-Zellrezeptors zur Behandlung von B-Zell-Non-Hodgkin-Lymphomen und anderen FMNL1-überexprimierenden Tumorerkrankungen vielversprechend.

Epstein-Barr Virus (EBV) is involved in several human malignancies via its latent gene products, which interact with cellular proteins and mimic discrete functions of cellular signalling pathways. Enigmatically, more than 90% of the human population carries this human tumour virus but virus-associated tumours are relatively rare. Most studies on EBV have been carried out in vitro and ex vivo on EBV-transformed human B cells or on human biopsies. Established in vivo model systems do not reflect the main aspects of EBV-associated diseases in humans. This limited tool set is the result of EBV’s inability to infect cells of non-human origin, which lack the surface receptor for EBV. My PhD work aimed at engineering a transgenic mouse, which carries a conditionally inactivated EBV genome. This study took advantage of the well-established techniques of mouse genetics in order to stably integrate the entire EBV genome into the murine genome. This approach would not only overcome the inability of EBV to infect animal cells but it would also permit to study the complete virus in an immunocompetent and easy-to-handle living organism. I undertook two routes to establish a transgenic mouse with the complete EBV genome inserted. One route was based on the site-specific integration into the hprt locus of murine embryonic stem cells. The other route engaged pronucleus microinjection of the EBV DNA into fertilized murine oocytes. In addition, the EBV genome was genetically manipulated prior to its introduction into murine cells. On the basis of the E.coli cloned EBV strain B95.8, I constructed a novel EBV mutant with unique features. This EBV targeting construct (InvTarg) allows conditional expression of EBV’s latent genes via a Cre/loxP system. Such approach prevents potentially adverse effects of EBV’s latent genes on embryonic development but allows their expression in almost any chosen cellular compartment for which specific Cre-expressing mice are available. The InvTarg recombinant EBV genome is 185 kb in size, based on a bacterial replicon, and therefore belonging to Bacterial Artificial Chromosomes (BACs). Two genetically modified and inversely oriented loxP sites were introduced in E.coli cells at the predetermined sites of the InvTarg, and the bracketed segment was inverted by Cre recombinase, disrupting transcription of almost all viral latent genes. In transgenic animals this inversion can be reverted and the latent genes can be re-activated at will by cross-breeding with Cre-expressing mouse (re-inversion). The ability of Cre to invert the big fragment was verified in infection experiments with human primary B cells. As expected, the ‘inverted’ EBV construct, such as InvTarg, failed to transform primary B cells, when the viral latent genes were not expressed. Despite sustained efforts, both gene delivery techniques did not lead to a transgenic mouse with the entire EBV genome inserted, but resulted in the integration of only subgenomic segments of the InvTarg recombinant EBV DNA. A number of technical problems were identified during this work, indicating more specific direction for further research. On the basis of the experience gained here, the project of an EBV transgenic mouse can be carried on. In addition, the InvTarg maxi-EBV conditional vector might be employed in other experimental conditions, like different cell types or distinct stages of cell differentiation, for studies on latent EBV genes.

Die Immuntherapie von niedrig malignen Tumoren stellt eine vielversprechende alternative Behandlungsmethode dar. Epstein Barr-Virus (EBV) etabliert eine latente Infektion in der Zielzelle, in der das EBV-Genom extrachromosomal aufrecht erhalten wird. EBV eignet sich mit diesen Eigenschaften hervorragend als Genvektor. Meine Aufgabenstellung war es, neue EBV-abgeleitete Genvektoren zu entwickeln, die das therapeutische Zytokin GM-CSF in Tumorzellen von B-CLL-Patienten (Chronische lymphatische Leukämie) exprimieren. Dabei entscheidend ist die Eigenschaft von EBV naive, wie auch reife und maligne B-Lymphozyten über den CD21-Rezeptor spezifisch zu infizieren. Als Grundlage diente das Maxi-EBV-System, mit dem das EBV-Genom für genetische Veränderungen zugänglich ist. Im Rahmen dieser Arbeit wurde ein sicherer EBV-Basis-Vektor etabliert, der replikations-defizient ist und dem zusätzlich die immortalisierenden Eigenschaften von EBV fehlen. Im selben Zuge wurden verschiedene Expressionskassetten für das Transgen GM-CSF in den EBV-Basis-Vektor eingebracht. Es konnten fünf unterschiedliche GM-CSF-Vektoren etabliert werden, die das Transgen an verschiedenen Genorten innerhalb des Maxi-EBV-Genoms tragen. Zwei dieser GM-CSF-Vektoren erzielten besonders hohe Transduktionseffizienzen und Expressionsraten in der Modellzelllinie Raji (Burkitt-Lymphom-B-Zelllinie). Auch B-CLL-Zellen konnten mit guter Effizienz transduziert werden, die Expression des GM-CSF war aber deutlich schwächer. Das immunstimulatorische Zytokin GM-CSF führt in vivo zu einer verbesserten Immunantwort gegen Tumore. Es konnte in dieser Arbeit gezeigt werden, dass GM-CSF-haltige Überstände von Vektor-transduzierten Raji-Zellen eine Reifung von dendritischen Zellen (DC) bewirken, die als wichtige Effektoren bei einer Anti-Tumorantwort gelten. Die Funktion von GM-CSF konnte auch anhand eines Proliferationsversuchs mit einer Zytokin-abhängigen Zelllinie gezeigt werden. Darüber hinaus waren DC nach exogener Antigenbeladung in der Lage, spezifischen CD4-positiven T-Zell-Klonen effizienter ein antigenes Peptid zu präsentieren, wenn die DC in Gegenwart von GM-CSF gereift waren. Damit zeigt das nach Gentransfer sezernierte GM-CSF einen immunstimulatorischen Effekt ähnlich dem von rekombinantem GM-CSF und kann eine effizientere Antigenpräsentation von Tumorantigenen hervorrufen. Prinzipiell eignen sich B-CLL-Zellen daher als Produzenten von EBV-Genvektor-transduziertem GM-CSF, das zur immunologischen Demaskierung von B-CLL-spezifischen, tumor-assoziierten Antigenen auch in vivo führen sollte.

Ziel dieser Arbeit war es, mit Hilfe von Mutanten den Einfluss der Proteine BALF1, BHRF1 und LMP2A von Epstein-Barr Virus (EBV) auf die B-Zell-Immortalisierung zu bestimmen. Diese EBV Mutanten bilden die Grundlage zur Funktionsanalyse der Genprodukte in infizierten humanen B-Zellen, die durch die Infektion mit EBV als stabile B-Zelllinien in vitro proliferieren und latent, d.h. ohne Virus zu produzieren, mit EBV infiziert sind. Die Einzeldeletionen von BALF1 oder BHRF1 im Genom von EBV zeigen keinen Einfluss auf die Effizienz, mit der solche B-Zelllinien entstehen. Die in beiden Genen deletierte Mutante ist dagegen nicht mehr in der Lage, die Proliferation von BLymphozyten zu induzieren. Eine LMP2A Deletionsmutante ist gegenüber Wildtyp EBV in dieser Eigenschaft deutlich beeinträchtigt. LMP2A induziert in frisch infizierten B-Lymphozyten die Expression von EBV Genen, die nicht zur Gruppe der latenten Genprodukte gehören, sondern nur während der Virusproduktion transkribiert werden. Allerdings werden keine Viren gebildet, da der lytische Zyklus nicht vollständig durchlaufen wird. Ebenso unerwartet ist die Expression des anti-apoptotischen Proteins BHRF1, das auch zu den lytischen Genen gehört und dessen Expression kurz nach der Infektion primärer B-Zellen nachzuweisen war. Diese Ergebnisse führten im Rahmen dieser Arbeit zu der Hypothese eines dritten Infektionsmodus von EBV: die Initiation der Latenz. Dabei wird die Apoptose in der infizierten Zelle durch BHRF1 verhindert, bis die Latenz etabliert ist. Später können anderen Proteinen von EBV wie z.B. LMP1, dessen antiapoptotische Eigenschaften bereits beschrieben ist, diese Aufgaben übernehmen. Der bisher ungeklärte Mechanismus der Replikation des viralen Genoms von einem auf bis zu mehreren Hundert Kopien ist während der Initiation der Latenz durch einen der lytischen Replikation ähnlichen Vorgang zu erklären. LMP2A wurde bisher immer mit der Unterdrückung des lytischen Zyklus und der Aufrechterhaltung der Latenz in der infizierten Zelle in Verbindung gebracht. Um die Funktion dieses Proteins besser untersuchen zu können, wurde ein konditionales LMP2A Zellsystem entwickelt. Dieses Systems ermöglicht eine kontrollierte LMP2AAktivierung, um die induzierten Signalwege und Zielgene von LMP2A in der Zelle zu identifizieren.

Epstein-Barr Virus (EBV) infiziert ruhende primäre humane B-Zellen und induziert deren unbegrenzte Proliferation. Dieser Prozess der B-Zell-Immortalisation ist ein Modellsystem, das die pathogenetischen Mechanismen bei der Tumorentstehung widerspiegelt. In vitro gilt das virale latente Membranprotein 1 (LMP1) für die Immortalisation von B-Zellen als essentiell. LMP1 ist ein integrales Membranprotein, das als konstitutiv aktivierter Pseudorezeptor verschiedene Signalwege in der B-Zelle induziert und dabei analoge Funktionen zum zellulären CD40-Rezeptor wahrnimmt. Das Genom des EBV ist in dem Maxi-EBV-System einer genetischen Manipulation zugänglich. Zuerst habe ich verschiedene Mutanten des LMP1 Gens im Kontext des EBVGenoms etabliert und auf ihren Phänotyp untersucht. Überraschenderweise war es möglich, mit allen LMP1 mutierten EBVs proliferierende B-Zellklone zu generieren, dies gelang sogar mit einer „knock out“ Mutante des kompletten LMP1 Gens. Die zehn verschiedenen LMP1- Mutanten unterschieden sich gravierend in ihrer Effizienz, B-Zellen zu immortalisieren. So wurden bis zu 100 mal mehr Virionen benötigt, um z.B. mit der LMP1-„knock out“-Mutante proliferierende B-Zellklone zu etablieren. Eine solche B-Zelllinie wies in einem in vivo Experiment mit SCID-Mäusen im Gegensatz zu B-Zelllinien mit Wildtypvirus kein onkogenes Potential auf. Im Widerspruch zu den bisherigen Veröffentlichungen einer anderen Gruppe zeigen meine Ergebnisse, dass LMP1 für den Prozess der B-Zell-Immortalisation in vitro zwar kritisch, aber nicht zwingend notwendig ist. Für die Onkogenität von EBV in vivo ist LMP1 dagegen absolut essentiell. Die Zielgene des LMP1, die die verschiedenen Effekte wie B-Zell-Immortalisation, Onkogenität und Tumorentstehung vermitteln, sind nicht vollständig bekannt. Ein zweites Ziel dieser Arbeit war deshalb die umfassende Katalogisierung dieser Zielgene. Da LMP1 und der CD40-Rezeptor analoge Funktionen und gemeinsame Signalmediatoren und -wege aufweisen, sollten vergleichende Untersuchungen von LMP1- und CD40-regulierten Genen durchgeführt werden. Zu diesem Zweck wurde ein konditionales LMP1-System in humanen B-Zellen etabliert, das es erlaubt, LMP1-Signaltransduktion innerhalb eines sehr kurzen, definierten Zeitraums zu induzieren und differentiell exprimierte Gene zu identifizieren. Da der CD40-Rezeptor auf humanen B-Zellen konstitutiv exprimiert ist und durch Interaktion mit seinem Liganden aktiviert werden kann, konnte die Analyse CD40-regulierter Zielgene im selben Zellsystem erfolgen. Unter Anwendung von ATLAS Array-Filtern und Affymetrix Chips wurden 144 LMP1- und 28 CD40-regulierte Gene identifiziert. Schließlich konnte in Zellzyklusanalysen gezeigt werden, dass LMP1-Signale in humanen B-Zellen echte proliferative Effekte vermitteln und nicht nur anti-apoptotische Funktionen erfüllen.