Podcasts about aberrations

In this Remastered Episode of the RPGBOT.Podcast, we summon the horrors that make your players ask, ‘Can I roll to nope?' In this episode, the RPGBOT.Podcast team delves into the weird, the squishy, and the utterly incomprehensible world of Aberrations—those delightful horrors that break the rules of reality and challenge players' expectations. From Mind Flayers to Gibbering Mouthers, the hosts explore how these creatures can be used to discomfort, disorient, and delight your game table. Whether you're looking to run a horror campaign, design a disturbing encounter, or just want to terrify your players with something that doesn't have a front or back, this episode will help you lean into the madness. Meeting an Ancient Aboleth – dScryb (affiliate link) RPGBOT.Podcast Episodes RPGBOT.Podcast Episode 10 – Horror Kobold Press Tome of Heroes: the Wit and Wisdom of Brian Suskind – RPGBOT.News S2E53 Journeys Through the Radiant Citadel – RPGBOT.News S2E57 Dice Math – RPGBOT.Podcast S2E92 Keith Baker on Eberron – RPGBOT.Masterclass S3E3 Keys from the Golden Vault – RPGBOT.News S3E17 The Undead – A Guide to Incorporating Undead Creatures in TTRPGs – RPGBOT.Podcast S3E28 The Undead II: A Guide for Role Playing Undead Creatures in TTRPGs – RPGBOT.Podcast S3E30 Content from RPGBOT.net Call of Cthulhu Starter Set – A Review Other Stuff Baldur's Gate Chaosium Basic Roleplaying System (affiliate link) Monstrous Races (affiliate link) Key Takeaways Aberrations thrive on unpredictability: Their alien logic and bizarre abilities create dynamic and disorienting encounters that force players to think outside the stat block. They are story tools, not just combatants: Aberrations can shape entire arcs, create cults, distort time and space, and redefine a campaign's tone. Use description and mechanics together: Emphasize the unnatural—describe how a Beholder's eye twitches in impossible ways, or how an Aboleth speaks directly into a PC's nightmares. Madness and corruption are your allies: Aberrations are best when they leave a lingering mark, be it psychic scars, corrupted NPCs, or twisted reality. Players should come prepared to counter tricks, not just tank hits: Aberrations reward clever tactics, good preparation, and understanding of their lore. Suggested Resources Volo's Guide to Monsters – Excellent for Mind Flayer and Beholder lore. Tasha's Cauldron of Everything – Optional rules for madness and tone setting. Spelljammer: Adventures in Space – For space aberrations and bizarre origin stories. Call of Cthulhu RPG – If you want to go full horror inspiration. If you enjoy the show, please rate and review us on Apple Podcasts, Spotify, or your favorite podcast app. It's a quick, free way to support the podcast, and helps us reach new listeners. If you love the show, consider joining us on Patreon, where backers at the $5 and above tiers get ad free access to RPGBOT.net and the RPGBOT.Podcast, can chat directly to members of the RPGBOT team and community on the RPGBOT.Discord, and can join us for live-streamed recordings. Support us on Amazon.com when you purchase products recommended in the show at the following link: https://amzn.to/3NwElxQ How to Find Us: In-depth articles, guides, handbooks, reviews, news on Tabletop Role Playing at RPGBOT.net Tyler Kamstra BlueSky: @rpgbot.net TikTok: @RPGBOTDOTNET Ash Ely Professional Game Master on StartPlaying.Games BlueSky: @GravenAshes YouTube: @ashravenmedia Randall James BlueSky: @GrimoireRPG Amateurjack.com Read Melancon: A Grimoire Tale (affiliate link) Producer Dan @Lzr_illuminati

In this Remastered Episode of the RPGBOT.Podcast, we summon the horrors that make your players ask, ‘Can I roll to nope?' In this episode, the RPGBOT.Podcast team delves into the weird, the squishy, and the utterly incomprehensible world of Aberrations—those delightful horrors that break the rules of reality and challenge players' expectations. From Mind Flayers to Gibbering Mouthers, the hosts explore how these creatures can be used to discomfort, disorient, and delight your game table. Whether you're looking to run a horror campaign, design a disturbing encounter, or just want to terrify your players with something that doesn't have a front or back, this episode will help you lean into the madness. Meeting an Ancient Aboleth – dScryb (affiliate link) RPGBOT.Podcast Episodes RPGBOT.Podcast Episode 10 – Horror Kobold Press Tome of Heroes: the Wit and Wisdom of Brian Suskind – RPGBOT.News S2E53 Journeys Through the Radiant Citadel – RPGBOT.News S2E57 Dice Math – RPGBOT.Podcast S2E92 Keith Baker on Eberron – RPGBOT.Masterclass S3E3 Keys from the Golden Vault – RPGBOT.News S3E17 The Undead – A Guide to Incorporating Undead Creatures in TTRPGs – RPGBOT.Podcast S3E28 The Undead II: A Guide for Role Playing Undead Creatures in TTRPGs – RPGBOT.Podcast S3E30 Content from RPGBOT.net Call of Cthulhu Starter Set – A Review Other Stuff Baldur's Gate Chaosium Basic Roleplaying System (affiliate link) Monstrous Races (affiliate link) Key Takeaways Aberrations thrive on unpredictability: Their alien logic and bizarre abilities create dynamic and disorienting encounters that force players to think outside the stat block. They are story tools, not just combatants: Aberrations can shape entire arcs, create cults, distort time and space, and redefine a campaign's tone. Use description and mechanics together: Emphasize the unnatural—describe how a Beholder's eye twitches in impossible ways, or how an Aboleth speaks directly into a PC's nightmares. Madness and corruption are your allies: Aberrations are best when they leave a lingering mark, be it psychic scars, corrupted NPCs, or twisted reality. Players should come prepared to counter tricks, not just tank hits: Aberrations reward clever tactics, good preparation, and understanding of their lore. Suggested Resources Volo's Guide to Monsters – Excellent for Mind Flayer and Beholder lore. Tasha's Cauldron of Everything – Optional rules for madness and tone setting. Spelljammer: Adventures in Space – For space aberrations and bizarre origin stories. Call of Cthulhu RPG – If you want to go full horror inspiration. If you enjoy the show, please rate and review us on Apple Podcasts, Spotify, or your favorite podcast app. It's a quick, free way to support the podcast, and helps us reach new listeners. If you love the show, consider joining us on Patreon, where backers at the $5 and above tiers get ad free access to RPGBOT.net and the RPGBOT.Podcast, can chat directly to members of the RPGBOT team and community on the RPGBOT.Discord, and can join us for live-streamed recordings. Support us on Amazon.com when you purchase products recommended in the show at the following link: https://amzn.to/3NwElxQ How to Find Us: In-depth articles, guides, handbooks, reviews, news on Tabletop Role Playing at RPGBOT.net Tyler Kamstra BlueSky: @rpgbot.net TikTok: @RPGBOTDOTNET Ash Ely Professional Game Master on StartPlaying.Games BlueSky: @GravenAshes YouTube: @ashravenmedia Randall James BlueSky: @GrimoireRPG Amateurjack.com Read Melancon: A Grimoire Tale (affiliate link) Producer Dan @Lzr_illuminati

  You know that poor sleep leaves you dragging through the day, feeling drained and foggy brained, and more than a little bit grouchy. But did you know that poor sleep can be deadly? Stay tuned to learn about seven serious diseases linked to poor sleep  I'm Dr.Vickie Petz Kasper. Healthy Looks Great On You podcast takes you to mini medical school so you can learn the power of lifestyle medicine. If you're ready to take control of your health, you're in the right  place. This is episode 158, The Risky Business of Poor Sleep, Seven Serious Diseases.  You know you need to get a good night's sleep.  You want to rest and wake up feeling refreshed and restored, but it's not that simple for everyone. Even though sleep is essential for life, chronic insomnia affects 30 percent of adults, and half of all people experience some degree of insomnia during their lives. So if you struggle to sleep, you certainly aren't alone. But, before you start planning a zombie party for all of your friends who are raring to go long after bedtime, let's take a look at the impact on your health. And, spoiler alert, it ain't good for ya.  Not only does poor sleep affect the quality of life and emotional well being, it's associated with an increased risk of seven serious diseases. I mean, it's bad enough to slog through the day sleepy, irritable, and feeling blah, but people with significant insomnia tend to have a shorter lifespan.  I mean, if they know Jesus, they can sleep in heavenly peace, but in the meantime, it's best to maximize restorative sleep because of the impact on health.  And before you reach for the medicine bottle or go shopping down the supplement and sleep aid aisle, you're going to want to stay tuned to this podcast because next week we're going to break down all the pills and potions. But this week we're going to talk about what the following conditions all have in common: heart disease, , type 2 diabetes, depression, obesity, Alzheimer's dementia, immune dysfunction, and certain cancers. And you don't even need to go to mini medical school to guess that poor sleep increases the risk of developing all seven of these serious diseases. Good sleep is crucial for good health.   I know, I know, you get it. You know sleep is super important. You want to sleep. You've tried to sleep, but you can't. I hope you know, I feel your pain. I've been there and I understand the frustration of going to bed and knowing you're not going to sleep. That's why I've created some resources for you. Head on over to my website, www.healthylooksgreatonyou. com and grab "Turn Off Your Mind and Sleep."  It's a free downloadable tip sheet. It's not a cure, but it's a start. And then in March of 2025, I'll be doing a series of live webinars called " Six Hidden Reasons You're Tossing and Turning." Then in the middle of the month, I'll release my online course: "Unlock the Secret to Sleep" to help you get the Z's you need. And if you take advantage of any of the free resources on my website, you'll automatically be subscribed to get every episode of this podcast, plus all those bonuses right in your inbox. And you'll be the first to know about additional opportunities to improve your sleep and health.  Now last month, I did a series of podcast episodes on dementia and now I'm transitioning to sleep. But before we exit this road Let's take a look at the intersection between brain health and sleep. I've already given you the list of seven diseases associated with poor sleep, and so this is not in order, but logically I thought we would discuss Alzheimer's dementia first. And if you missed the series, there are links in the show notes to each episode, but if you just want the bottom line. Lifestyle modifications are your best weapon to prevent this disease which is exploding in our aging population.  Now, today in mini medical school, we're going to learn about beta amyloid, which is sometimes referred to as amyloid beta.  That's kind of weird. I guess this peptide is a little confused about which name comes first. You can call me beta amyloid or you can call me amyloid beta, but you don't have to call me Ray.  Okay, that was a poor attempt at humor,  but I stand by the fact that laughter is still the best medicine.  What's in a name? Well, Dr. Alzheimer himself identified senile plaques, which are those buildups of beta amyloid in the brain, as well as neurofibrillary tangles which come from Tau proteins. And he discovered all of this in the early 1900s.  In people with Alzheimer's, amyloid proteins stick together and get folded over and they form plaques and that is toxic to brain cells. In fact, beta amyloid plaques are the hallmark finding in the brains of people with Alzheimer's. But here's the deal.  I've got amyloids and you've got amyloids in your brain, too.  But if you're normal, then your glymphatic system washes it away and breaks it down.  Want to guess when this happens?  Yep, while you were sleeping.  Or in the case of insomnia, not. And clearly, there's an increased risk of Alzheimer's dementia in people with mid life insomnia.  As it turns out, a lot of things in midlife have long term effects on our health. So maybe if you think you got away with not paying attention to your health when you were young, now is the time to reset and change directions.  Need a little more motivation? Well, let's move on to the increased risk of cardiovascular disease. And that's a catch all term that refers to heart disease, heart attack, and high blood pressure. Cardio means heart, and vascular refers to blood vessels. And guess what? You've got blood vessels in your heart and throughout your body. So what's sleep got to do with it? Well, I'm glad you asked. Insomnia is considered an independent risk factor for cardiovascular disease and is associated with a higher chance of dying from heart disease or anything else for that matter. We call that mortality. And listen, I know we are all going to die of something, but the goal of this podcast is to give you information, motivation, and inspiration to take care of this one body God gave us to last a lifetime on this earth. So yeah, I'm going to die of something and so are you. But I'd really like to stick around for a while with the people I love, wouldn't you? And I want to be healthy enough to play and enjoy life. And cardiovascular disease can rob you of the ability to do anything that requires stamina. So don't give me that, we're all gonna die of something line. Eventually your car is going to have enough miles that the engine fails. But that doesn't mean you shouldn't get your oil changed on a regular basis. Maintenance for your health is so much more important than maintenance for your vehicle. I mean, you can't replace your body. So pay attention to your heart health and sleep. They're all related. Now let's explore why poor sleep  affects heart health. You know, when you sleep, not only is your glymphatic system clearing out toxins from your brain, but your sympathetic nervous system is just kind of chill, and your blood pressure drops. But when instead your blood vessels don't relax, that causes an elevation in blood pressure. And not only does that increase the risk of hypertension and heart disease, But also stroke.  Now, this is interesting. If you can't sleep because you wake up during the night, or you wake up super early in the morning, then your blood pressure probably doesn't do the normal dip.  But, if you have trouble falling asleep at the beginning of the night, it doesn't seem to have as much effect on your blood pressure. You see, sleep is very specific and complex, and the type of sleep trouble you have affects your risk. If you're interested in learning more about blood pressure, then when you go to my website, healthylooksgreatonyou.com, and search for four reasons to control your blood pressure, There'll be an episode that pops up and of course I'll put a link in the show notes.  Okay, we've covered the brain and the heart and blood vessels. Now sweetie, it's time to talk about those sugar plums dancing in your head because insomnia is associated with an increased risk of type 2 diabetes as well as progression from pre diabetes to type 2 diabetes.  Want some good news? Improving your sleep can improve your glycemic control. That means it's easier to normalize your blood sugars with a good full eight hours of shut eye. And specifically, short sleep duration is associated with an increased risk of diabetes.  Both inflammation and insulin resistance are increased with poor sleep.  And if you're interested in more of the science made simple, listen to the episode, "Why is sleeping so hard?" But here's the deal, sugar causes inflammation. And insulin is the key that opens the door to move the sugar out of the blood vessels and into your cells. So, it can be used as fuel. But with type 2 diabetes, this mechanism is impaired.  This all goes back to a coordinated effort by the body to balance various hormones like growth hormone, insulin, and cortisol. And yes, it's all affected by sleep..  Next in the list of seven deadly diseases associated with poor sleep is cancer. In fact, researchers have proposed a 24 percent increased risk of cancer in people with insomnia. And it's certain cancers in particular, like lung cancer, colorectal cancer, breast cancer, and ovarian cancer. Turns out that disrupting your internal clock does more than keep you wide eyed and bushy tailed. It's theorized that cancer cells may take advantage of lower levels of the sleep hormone, melatonin. You see, melatonin is released in the brain and  sends out signals to synchronize many organs and bodily functions. And it plays a huge role in hormone balance. Things like estrogen, but also cortisol. And this affects cellular growth and repair at the DNA level. That's where genes are switched on and off by the immune system.  At the most basic level, cancer is an abnormal growth of cells. So, it's plausible that skimping on the cleanup and reboot system for your body's defenses gives the enemy an advantage. Both inflammation and insulin resistance contribute to DNA damage and that can increase the risk for cancer. I feel like I could just repeat the word inflammation with each of these seven diseases. Inflammation in the blood vessels affects every organ supplied by.. blood.  And well, that pretty much covers it all,  but also inflammation's life partner is the immune system.  You know, they're still married, but they fight a lot trying to find the perfect balance between keeping out foreign invaders that have come to kill and destroy like infection and cancer and not going nuclear and exploding your body's own cells.  So that leads to number five on the list of deadly diseases associated with poor sleep, and that is immune dysfunction,  and if you think you have a dysfunctional family Let me tell you about the immune system Try putting the bone marrow, the thymus gland, the spleen, mucous membrane, skin, tonsils, and lymph nodes in a room together and watch them go into attack mode. They'll crank out some white blood cells, antibodies, cytokine, and compliment to mount a defense against infection. And that's a good thing. When bacteria, viruses, parasites, and fungus breaches our first line of protection, We need a strong immune system to fight them off. Turns out that fighting off infection is a process that's also related to tumor suppression like we discussed with cancer. But here's the deal. The immune family is a rowdy bunch and sometimes they miss the target and attack their own. I mean, you've seen a room full of toddlers, right? They want everything. That's mine. It's mine. That's their favorite phrase. So when they get overzealous, it causes autoimmune disease. Okay, now this is getting personal. I have an autoimmune disease called myasthenia gravis. In this condition, the body makes antibodies against itself. And we all know that a house divided against itself cannot stand. And that's what happened to me. Literally, my muscles were so weak, I couldn't stand for very long, walk very far, or use my arms for any length of time. Because every time my nerves tried to send a signal to my muscles, my misguided immune system interrupted the neurotransmitter as if it were there to hurt me. Now, what causes myasthenia gravis? Well, it's not really known, but guess what? Poor sleep is associated with immune dysfunction. Now, I was a self described health nut for many years. I ate a lot of whole, unprocessed foods, exercised regularly, managed my stress pretty well, and had a healthy group of connections.  Oh, and my mama always said, don't drink, don't smoke, don't chew, and don't go with those who do. So I've never been one to be exposed to unhealthy levels of harmful substances. Now, I just listed five of the six pillars of lifestyle medicine. Hmm, let me see, what did I leave out? Oh, yeah, sleep. Until MG knocked me flat on my back, I ignored the importance of rest and sleep on my health  and it caught up with me. And that's one of the reasons I'm so passionate about restorative sleep.  Let those who've lived like the walking dead serve as a warning.  And if dementia, heart disease, cancer, diabetes, and immune health aren't enough to convince you that you need to prioritize sleep. Then how about obesity?  And listen, do you see a theme developing? Aberrations in the circadian rhythm disrupt normal melatonin production, which in turn has a powerful influence in hormone regulation and balance. And all of that affects your levels of hunger and satisfaction, and ultimately, the number on the scales.  If you've ever wanted to reset your metabolism, then focus on resetting your sleep because they are closely related. And obesity increases the risk of heart disease, cancer, high blood pressure, and of course, type 2 diabetes. This is starting to feel like a snowball, gaining more and more waist circumference as it rolls down the hill. Not only does lack of sleep slow down your metabolism, it increases the level of the hunger hormone, ghrelin, and it decreases the satiety hormone, leptin, that tells your brain you're full.   I've already mentioned the connection between insulin and sleep. And insulin resistance is also a factor in excess weight gain. Both insomnia and obesity are epidemic. And look, you're not going to lose weight by sleeping better at night. But you might gain weight by not sleeping at night. And it might be easier for you to stay active and eat healthy if you get a good night's rest.  Gosh, this whole thing is kind of depressing.  You knew I was going there, didn't you? The seventh serious disease associated with poor sleep is depression. And get this, people with insomnia have a tenfold increased risk of depression. In one of my previous episodes, I called sleep the mood mechanic. There's a link in the show notes. But on the other side of the pillow. If you have depression, you have 75 percent more trouble falling asleep. Now, how do they measure that? Well, in the past, they relied on surveys where research subjects just recalled their sleep. But now, we're getting more and more data from wearables, like watches and rings and smart beds, like the sleep number bed. But the fact remains that sometimes it's hard to tell. If depression causes sleep disruption, Or the other way around. Listen, don't stay awake at night worrying about it. If you have depression, talk to your doctor or healthcare provider about the right treatment for you and your insomnia. Because I'm guessing, if you have one, you have both.  However, that leads me to reason number two that I'm passionate about sleep.  The average doctor only gets two and a half hours of training on sleep in medical school. So there's that. And the number one recommendation to treat insomnia is not medication. So, you're going to want to stay tuned and learn more so you can lower your risk of dementia, cardiovascular disease, type 2 diabetes, obesity, cancer, immune dysfunction, and depression.  Sleeping may not come easy for you, but it's worth the effort to give your body a chance to do the work on the night shift and restore your mind and your health. Because healthy looks great on you.        the information contained in this podcast is for educational purposes only and is not considered to be a substitute for medical advice. You should continue to follow up with your physician or health care provider and take medication as prescribed. Though the information in this podcast is evidence based, new research may develop and recommendations may change.   RESOURCES: FREE LIVE Webinars Turn off your mind and get some sleep free tip sheet 4 Reasons to control your blood pressure The work of sleep Why is sleeping so hard? Type 2 Diabetes Is it normal aging or dementia? 10 Must know risk factors for dementia

Ryan and Ben talk about the new Undead, Monstrosities, Aberrations, and Fey videos then discuss how to switch your current campaign to the new 2024 rules. Community Pages: Undead preview video; Undead video summary; Monstrosities preview video; Monstrosities video summary; Aberrations and Oozes preview video; Aberrations and Oozes video summary; Fey preview video; Fey video … Continue reading "Episode 127 – Monster Manual Sneak Peeks and Swapping to 2024"

The whole gang is here and Ryan David leads the discussion around what "bones" are a must-have for the perfect fantasy role playing game?  Spanning from philosophy to mechanics, the crew nominate elements that they simply couldn't exclude from their own "perfect D&D."  The news is just one article -- but what an article it is!  Do you know what your dice type tells the table about YOU?  After that silliness, the guys discuss aberrations including personal favorites and weaker entries.     ----more---- Episode Sponsors and Affiliates: Shop Amazon and Support the Show: https://amzn.to/3djotja *We earn a small commission for each Amazon purchase at no additional cost to you!

Professor Graham Barrett is joined by Professor Dan Reinstein and Mr Darshak Patel to discuss the benefits of RayOne EMV for post corneal refractive surgery patients, focusing on the importance of tailored approaches through careful diagnostics and lens selection to reduce the risk of post-operative complications. This podcast is provided for general information purposes only. The presenters' views are their own. Nothing contained within this podcast is intended to offer medical advice for the treatment of any illness or disease, nor is it a substitute for professional medical advice, diagnosis or treatment. Nothing presented in this podcast is intended to give instruction or guidance on the use of any Rayner products; it is not designed to replace a surgeon's independent judgement about the appropriateness or risks of a procedure for a given patient. Rayner does not endorse off-label use. Users must refer to the product labelling and instructions for use for Rayner products in all cases. Not all Rayner products are available in all countries. © 2024 Rayner Group, all rights reserved. Rayner is a proprietary mark of Rayner. All other trademarks are property of their respective owners. Rayner, 10 Dominion Way, Worthing, West Sussex, BN14 8AQ. Registered in England: 615539

Année après année, les hausses de primes tombent en automne comme un coup de massue sur les ménages romands. Mode de remboursement des appareils, surcoût des dispositifs en Suisse par rapport aux tarifs étrangers : ABE pointe des aberrations qui contribuent à alourdir la charge financière de notre système de santé.

In this episode of the It's A Mimic! podcast, this panel of Dungeon Masters is going to finally dig into three of the most classic and iconic aberrations that aren't part of an army from beyond the stars! Cold Open 0:00 Opening Theme 2:35 Intro 2:56 Info Break 5:44 Gibbering Mouther 6:33 Grell 25:05 Otyugh 51:11 Info Break 1:13:19 Outro 1:13:46 Closing Theme 1:15:59 Post Credit 1:16:26 DON'T FORGET TO LIKE & SUBSCRIBE! Find Us On: Patreon at https://www.patreon.com/user?u=84724626 Website at https://www.itsamimic.com iTunes at https://itunes.apple.com/ca/podcast/its-a-mimic/id1450770037 Spotify at https://open.spotify.com/show/3Y19VxSxLKyfg0gY0yUeU1 Podbean at https://itsamimic.podbean.com/ YouTube at https://www.youtube.com/channel/UCzQmvEufzxPHWrFSZbB8uuw Social: Facebook at https://www.facebook.com/itsamimic/ Instagram at https://www.instagram.com/itsamimic/?hl=en Reddit at https://www.reddit.com/r/ItsaMimic/ Email at info@itsamimic.com Dungeon Master 1:  Kyle McQuaid Dungeon Master 2:  Adam Nason Dungeon Master 3:  Megan Lengle Narrator:  Terry Williams Written by:  Kyle McQuaid and Adam Nason Director:  Kyle McQuaid and Adam Nason Editor:  Adam Nason Executive Producer:  Adam Nason Intro/Outro Music by:  Cory Wiebe All other music provided by Tyler Gibson at https://www.instagram.com/melodicasmusic Logo by:  Katie Skidmore at https://www.instagram.com/clementineartportraits/ This episode is meant to be used as an inspirational supplement for Dungeons & Dragons 5th Edition and tabletop roleplaying games in general.  It's A Mimic! does not own the rights to any Wizards of the Coasts products. Artwork included in this episode's video visualizations is published and/or owned by Wizards of the Coast.

In this episode, we speak with Roderick Ferguson about two of Josh's all-time favorite books, One-Dimensional Queer and Aberrations in Black: Toward a Queer of Color Critique.  The former which problematizes single-issue politics that came to dominate, disrupt, capture, and destroy the gay liberation movement—and has continued to plague queer (anti-) politics today.  And the latter which discusses the regulation of sexual difference and its role in circumscribing Black-African culture.  Throughout the conversation, we discuss the concept of one-dimensionality—which Ferguson borrows from Herbert Marcuse—and how the mobilization of the concept in queer struggles “[drove] a wedge between queer politics and other progressive formations.” We also discuss how the structural realities imposed through capitalism, racialized violence and neglect, have made the nuclear family unit a “material impossibility” for non-white people—namely Black-African people.  Roderick A. Ferguson is the William Robertson Coe Professor of Women's, Gender, and Sexuality Studies and American Studies at Yale University.  He is also faculty in the Yale Prison Education Initiative. He is the author of One-Dimensional Queer, We Demand: The University and Student Protests, The Reorder of Things: The University and Its Pedagogies of Minority Difference, and Aberrations in Black: Toward a Queer of Color Critique. He is the co-editor with Grace Hong of the anthology Strange Affinities: The Gender and Sexual Politics of Comparative Racialization. He is also co-editor with Erica Edwards and Jeffrey Ogbar of Keywords of African American Studies (NYU, 2018). He is the 2020 recipient of the Kessler Award from the Center for LGBTQ Studies (CLAGS). If you like what we do and want to support our ability to have more conversations like this. Please consider becoming a patron. You can do so for as little as a $1  a month.  This episode was produced and edited by Aidan Elias

Tom and Dan rather chaotically investigate the world of aberrations in 5e, including some creations of Cawood Publishing. Learn more about monster combat strategies HERE. Connect with us: teachersinthedungeon on Instagram and Facebook, @dungeonteachers on X, and teachersinthedungeon@gmail.com

[originally published on Patreon Sep 22, 2023] cw: rape, assault, etc. This is the first episode about the serial killer Israel Keyes. I begin with the logical starting place: the Keyes family, and get into a brief history of Christian Identity in the UK and US. From there, we discuss the Kehoe family including some interesting details which are often left out of the conversation. Then I go over Israel's early life and upbringing, his early military service, his first major relationship, and end discussing Israel's Grand Plan. (note 1: I wrote and recorded this before I had Wendy Painting on the show and consequently realized I kept saying 'Aberrations' instead of Aberration in the Heartland of the Real, the correct title note 2: I have learned much more about Fort Gulick since writing these episodes and I think Keyes was trained there) Songs: I Saw the Sign by Ace of Base Loco by Coal Chamber (when talking about psychiatric evaluation?) TRYNA SPIT GAME by STOVE X DJ AKOZA (outro)

Aboleths and Algholthu are amphibious creatures who feel they are gods whose domains have been wrongfully stolen from them by those who they feel should be their slaves.  They are extremely savvy fighters who remember eons of combats and use those lessons when the PCs show up to try to kill them.  In this episode we talk about these huge aberrations and how to use them in your game.   #dnd #5e #pf2e #aboleths #algholthu #aberrations Resources: D&D 2025 - Creative Commons - https://www.wargamer.com/dnd/edition-2024-sourcebooks-srd-creative-commons Riches and Liches - D&D Lore: Monster Lab - Aboleth https://www.youtube.com/watch?v=fwHRDlgi5QI&t=298s The Monsters Know What They're Doing - Aboleths by Keith Amman - https://www.themonstersknow.com/aboleth-tactics/ The Lords of Madness - The Book of Aberrations

BUFFALO, NY- April 16, 2024 – A new #researchpaper was #published in Oncotarget's Volume 15 on April 12, 2024, entitled, “Novel therapeutic bispecific antibodies for B-cell lymphoma targeting IgM and other antigens on the B-cell surface.” The B-cell receptor regulates B-cell proliferation and apoptosis. Aberrations in BCR signaling are associated with the development and progression of B-cell malignancies, such as mantle cell lymphoma, diffuse large B-cell lymphoma, and chronic lymphocytic leukemia, many of which express the IgM type of BCR on their cellular surface. Therefore, IgM is an attractive target for therapeutic antibodies against B-cell malignancies. However, soluble IgM competitively binds to anti-IgM antibodies in the serum, and these antibodies show insufficient cytotoxic activity. Thus, antibody therapy targeting IgM is hindered by the presence of soluble IgM in the blood. In this new study, researchers Takahiro Ohashi, Sayuri Terada, Shinsuke Hiramoto, Yuko Nagata, Hirokazu Suzuki, Hitoshi Miyashita, Tetsuo Sasaki, Yasukatsu Tsukada, and Keiko Fukushima from ZENOAQ (Zenyaku Kogyo Co., Ltd.) used a bispecific antibody to address this problem. “In this study, we aimed to produce IgM-dependent bispecific antibodies targeting IgM and the other B-cell antigens such as CD20, CD32b (FcγRIIB), CD79b, and human leukocyte antigen (HLA)-DR using the Cys1m technology [10, 43–45]. Additionally, the correct IgG-like bispecific antibody structures were confirmed and their efficacies in the presence of soluble IgM were analyzed.” The researchers generated bispecific antibodies bound to IgM and other B-cell antigens such as CD20 and HLA-DR using their own bispecific antibody-producing technology, Cys1m. These bispecific antibodies directly inhibited cell proliferation via cell-cycle arrest and apoptosis in vitro, although large amounts of soluble IgM were present. Additionally, a bispecific antibody bound to IgM and HLA-DR (BTA106) depleted B-cells in cynomolgus monkeys. “These data suggest that anti-IgM/B-cell surface antigen-binding specific antibodies are promising therapeutic agents for B-cell malignancies. Moreover, the bispecific antibody modality can potentially overcome problems caused by soluble antigens.” DOI - https://doi.org/10.18632/oncotarget.28578 Correspondence to - Keiko Fukushima - keiko_fukushima@mail.zenyaku.co.jp Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28578 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, bispecific antibody, Cys1m, IgM, lymphoma, cynomolgus monkey About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science). To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

Arriving to Fyren Y'Fin, a desert city controlled by the Caecilian Dynasty, the group meets with the royal Yuan-Ti that give them a job. Aberrations plague the city, and fighting these creatures will soon give way to more mysteries. --- Support this podcast: https://podcasters.spotify.com/pod/show/dragondeezdice/support

Its a Monster Mash this week as we talk about aberrations! Aberrations are creatures that cannot be easily grouped by physical description. These beings are often amorphous and alien. From the lowly mimic to the mighty beholder these nightmare creatures are often found underground or in the watery depths, seeking to devour or enslave. Sometimes both. Inspired in large part by the Cthulhu mythos, aberrations were part of early Dungeons and Dragons and have a place in many game settings and home tables. BECMI/Rules Cyclopedia: beholder,that's it.1e: Beholder, Mind flayer, Ixitxachitl, and a lot more https://dungeonsdragons.fandom.com/wiki/List_of_Advanced_Dungeons_%26_Dragons_1st_edition_monsters 2e: https://adnd2e.fandom.com/wiki/List_of_Monsters 3.x: https://www.dandwiki.com/wiki/3e_SRD:Aberration_Type 4e: https://dungeonsdragons.fandom.com/wiki/List_of_Dungeons_%26_Dragons_4th_edition_monsters 5e: https://www.dndbeyond.com/monsters?filter-type=1&filter-search=&filter-cr-min=&filter-cr-max=&filter-armor-class-min=&filter-armor-class-max=&filter-average-hp-min=&filter-average-hp-max=&filter-is-legendary=&filter-is-mythic=&filter-has-lair=&filter-partnered-content=f Big Geek Con 2024 Tickets on sale: (Sept 20 - 22)https://tabletop.events/conventions/big-geek-con-2024 If you would like to support our show, please like, subscribe, and share us where you are listening or viewing the show,  we are on all the socials, video and podcast places as well. Cash SupportPayPal: https://paypal.me/biggusgeekus Streamlabs: https://streamlabs.com/biggusgeekus1/tipKo-fi: https://ko-fi.com/biggusgeekus Patreon: https://www.patreon.com/BiggusGeekus On the Web: Website: www.biggusgeekuspodcast.comEmail: thegeeks@biggusgeekuspodcast.comBig Geek Emporium: https://biggeekemporium.com/ --- Send in a voice message: https://podcasters.spotify.com/pod/show/biggusgeekus/message Support this podcast: https://podcasters.spotify.com/pod/show/biggusgeekus/support

L'ÉDITORIAL DU FIGARO - Les maires aux prises avec l'ubuesque ZAN - zéro artificialisation nette - de la loi climat et résilience constatent que l'idéologie verte a encore frappé, détachée de toute réalité du terrain.

Loremaster Sergio and Lore TA Shaun dig into the lore behind aberrations... mind flayers, beholders, and neogi OH MY! DnD Lorecast Discord | DnD Lorecast swag Homebrew Corner: The Aberration Hunter's Handbook New D&D video game in development MCDM RPG on BackerKit Equip your own adventures: D&D 5th Edition Starter Set: https://amzn.to/2WgZX6O  D&D 5th Edition Players Handbook: https://amzn.to/3iRtcH4  D&D 5th Ed Monster's Manual: https://amzn.to/2Eeh8Qp  38 Fantasy Miniatures: https://amzn.to/34kh6kX  Awesome Looking Dice Sets: https://amzn.to/3aHFwpM Links: Fandom University - Sergio's OTHER nerdy podcast! Multi-episodes arcs deep-diving into various nerdy topics **SEASON 1 NOW COMPLETE** NoSleep Podcast - online and on Twitch, a horror fiction podcast Mary helps work on Check out all the socials right here: https://linktr.ee/dndlorecast And send us a note! Email us at dndlorecast@gmail.com  ROBOTSRADIO.net - Smart Shows for Interesting People. Explore all the awesome shows on the network. Robots Radio Network Discord: discord.gg/JXKfVhM  Learn more about your ad choices. Visit megaphone.fm/adchoices

Loremaster Sergio and Lore TA Shaun dig into the lore behind aberrations... mind flayers, beholders, and neogi OH MY! DnD Lorecast Discord | DnD Lorecast swag Homebrew Corner: The Aberration Hunter's Handbook New D&D video game in development MCDM RPG on BackerKit Equip your own adventures: D&D 5th Edition Starter Set: https://amzn.to/2WgZX6O  D&D 5th Edition Players Handbook: https://amzn.to/3iRtcH4  D&D 5th Ed Monster's Manual: https://amzn.to/2Eeh8Qp  38 Fantasy Miniatures: https://amzn.to/34kh6kX  Awesome Looking Dice Sets: https://amzn.to/3aHFwpM Links: Fandom University - Sergio's OTHER nerdy podcast! Multi-episodes arcs deep-diving into various nerdy topics **SEASON 1 NOW COMPLETE** NoSleep Podcast - online and on Twitch, a horror fiction podcast Mary helps work on Check out all the socials right here: https://linktr.ee/dndlorecast And send us a note! Email us at dndlorecast@gmail.com  ROBOTSRADIO.net - Smart Shows for Interesting People. Explore all the awesome shows on the network. Robots Radio Network Discord: discord.gg/JXKfVhM  Learn more about your ad choices. Visit megaphone.fm/adchoices

Healthy//Toxic Healthy versus Toxic is a podcast where licensed mental health professionals explore what makes a relationship healthy or unhealthy. Our hosts aim to provide a scientifically informed perspective on what factors go into making healthy relationships, how to build secure attachment, and how to be a better parent, child, partner, or friend.  References: Buckels, E. E., Jones, D. N., & Paulhus, D. L. (2013). Behavioral confirmation of everyday sadism. Psychological Science, 24(11), 2201-2209. doi:10.1177/0956797613490749 Hyatt, C. S., Zeichner, A., & Miller, J. D. (2019). Laboratory aggression and personality traits: A meta-analytic review. Psychology of Violence, 9(6), 675–689. https://doi-org.mylibrary.wilmu.edu/1... Međedović, J. (2017). Aberrations in emotional processing of violence-dependent stimuli are the core features of sadism. Motivation and Emotion, 41(2), 273–283. https://doi-org.mylibrary.wilmu.edu/1... Music, G. gmusic@tavi-port. nhs. u. (2016). Angels and devils: sadism and violence in children. Journal of Child Psychotherapy, 42(3), 302–317. https://doi-org.mylibrary.wilmu.edu/1... Pfattheicher, S., & Schindler, S. (2015). Understanding the dark side of costly punishment: The impact of individual differences in everyday sadism and existential threat. European Journal of Personality, 29(4), 498–505. https://doi-org.mylibrary.wilmu.edu/1... Burris, C. T., & Leitch, R. (2018). Harmful fun: Pranks and sadistic motivation. Motivation and Emotion, 42(1), 90–102. https://doi-org.mylibrary.wilmu.edu/1... Reidy, D. E., Zeichner, A., & Seibert, L. A. (2011). Unprovoked aggression: Effects of psychopathic traits and sadism. Journal of Personality, 79(1), 75–100. https://doi-org.mylibrary.wilmu.edu/1... O'Meara, A., Davies, J., & Hammond, S. (2011). The psychometric properties and utility of the Short Sadistic Impulse Scale (SSIS). Psychological Assessment, 23(2), 523–531. https://doi-org.mylibrary.wilmu.edu/1... Nitschke, J., Blendl, V., Ottermann, B., Osterheider, M., & Mokros, A. (2009). Severe sexual sadism--an underdiagnosed disorder? Evidence from a sample of forensic inpatients. Journal Of Forensic Sciences, 54(3), 685–691. https://doi-org.mylibrary.wilmu.edu/1... Want more mental health content? Check out our other Podcasts: Mental Health // Demystified with Dr. Tracey Marks  True Crime Psychology and Personality Cluster B: A Look At Narcissism, Antisocial, Borderline, and Histrionic Disorders Here, Now, Together with Rou Reynolds   Links for Dr. Grande Dr. Grande on YouTube Produced by Ars Longa Media Learn more at arslonga.media. Produced by: Erin McCue Executive Producer: Patrick C. Beeman, MD Legal Stuff The information presented in this podcast is intended for educational and entertainment purposes only and is not professional advice. Learn more about your ad choices. Visit megaphone.fm/adchoices

Studies of revivals at the end of the 18th and beginning of the 19th centuries - Lesson 3 - The Kentucky Revival -2 Aberrations -2- The effect of -sympathy- in a revival. Other circumstances that affected this revival. The Revival of 1800 compared to the Revival at Asbury compared and contrasted. What factors lead to -revivalism---

Le Grand Prix du Qatar a été la scène de nombreux événements ce week-end : la troisième couronne mondiale de Max Verstappen, la première victoire d'Oscar Piastri en Formule 1 en course Sprint et l'obligation d'une stratégie à trois arrêts à cause de la dégradation des pneumatiques dimanche. On évoque tout cela et bien d‘autres dans le nouvel épisode des Fous Du Volant avec Gilles Della Posta et Stéphane Vrignaud.On commence avec la chaleur et l'humidité au Qatar, les pilotes ont terminé le Grand Prix épuisés et déshydraté à cause des conditions. Mais le facteur majeur qui a impacté la course c'est les pneumatiques. Obligés de faire 3 arrêts durant la course, les pilotes ont dû enchainer les tours de qualifications pour maximiser leurs chances. Gilles Della Posta et Stéphane Vrignaud analysent la course et le bilan à en tirer. Dans la deuxième partie, Max Verstappen a été couronné champion du monde de Formule 1 2023. Le Néerlandais décroche ainsi son 3e titre mondial consécutif. A 26 ans, il égale les plus grand noms de la discipline Ayrton Senna, Jackie Stewart, Niki Lauda. Quel est son plus beau titre jusqu'à présent ? Réponse de nos journalistes.Pour finir, d'après quelques indiscrétions reçues depuis le Qatar, l'avenir de Sergio Pérez se joue actuellement. Le pilote mexicain est mis sous pression par Red Bull, l'équation est simple : finir vice-champion du monde 2023 derrière son coéquipier triple champion du monde ou alors il perdra son volant dans l'écurie autrichienne en 2024. Nos journalistes font le point sur la situation.Bienvenue dans ce nouvel épisode des Fous du Volant 2023 et bonne écoute ! Présentation : Gilles Della Posta et Stéphane Vrignaud - Réalisation : Marion Rabot - Graphisme : Marko Popovic Ecoutez d'autres épisodes des Fous du Volant en vous abonnant sur Apple Podcasts. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

On today's episode #181, Unity decides to backtrack on a controversial price hike for their software amid backlash from developers, Neuralink begins open recruitment for their recently approved BCI implants, and we'll take a look at the list of who is striking in the US today. Also, announcements from several showcases, we tried out another one-shot, and of course, we've been playing games.

In this episode of the It's A Mimic! podcast, this panel of Dungeon Masters sits down and looks at a handful of very gnarly aberrations that sit at the beginning of Tier 3, but have the potential to completely wreck an unaware party. Cold Open 0:00 Opening Theme 3:54 Intro 4:16 Ad Break 9:09 Aboleth 10:56 Morkoth 1:10:26 Balhannoth 1:46:27 Ad Break 2:30:25 Outro 2:30:55 Closing Theme 2:34:46 Bloopers 2:35:13 DON'T FORGET TO LIKE & SUBSCRIBE! Find Us On: Patreon at https://www.patreon.com/user?u=84724626 Website at https://www.itsamimic.com iTunes at https://itunes.apple.com/ca/podcast/its-a-mimic/id1450770037 Spotify at https://open.spotify.com/show/3Y19VxSxLKyfg0gY0yUeU1 Podbean at https://itsamimic.podbean.com/  YouTube at https://www.youtube.com/channel/UCzQmvEufzxPHWrFSZbB8uuw Social: Facebook at https://www.facebook.com/itsamimic/ Instagram at https://www.instagram.com/itsamimic/?hl=en Reddit at https://www.reddit.com/r/ItsaMimic/ Email at info@itsamimic.com Dungeon Master 1:  Megan Lengle Dungeon Master 2:  Kyle McQuaid Dungeon Master 3:  Adam Nason Narrator:  Terry Williams Written by:  Megan Lengle and Adam Nason Director:  Megan Lengle and Adam Nason Editor:  Adam Nason Executive Producer:  Adam Nason Intro/Outro Music by:  Cory Wiebe All other music provided by Tyler Gibson at https://www.instagram.com/melodicasmusic Logo by:  Katie Skidmore at https://www.instagram.com/clementineartportraits/ This episode is meant to be used as an inspirational supplement for Dungeons & Dragons 5th Edition and tabletop roleplaying games in general.  It's A Mimic! does not own the rights to any Wizards of the Coasts products. Artwork included in this episode's video visualizations is published and/or owned by Wizards of the Coast.

On this episode of the RPGBOT.Podcast, we discuss aberrations. We look at all the weirdness from both a player's and a DM's perspective, and look at ways to make aberrations interesting and engaging in your game. If you've enjoyed the show, please rate and review us on Apple Podcasts, and rate us on Spotify or your favorite podcast app. It's a quick, free way to support the podcast, and helps us reach new listeners. Check out our Best of Season 1 and Best of Season 2 playlists! MATERIALS REFERENCED IN THIS EPISODE Meeting an Ancient Aboleth – dScryb (affiliate link) RPGBOT.Podcast Episodes RPGBOT.Podcast Episode 10 – Horror Kobold Press Tome of Heroes: the Wit and Wisdom of Brian Suskind – RPGBOT.News S2E53 Journeys Through the Radiant Citadel – RPGBOT.News S2E57 Dice Math – RPGBOT.Podcast S2E92 Keith Baker on Eberron – RPGBOT.Masterclass S3E3 Keys from the Golden Vault – RPGBOT.News S3E17 The Undead – A Guide to Incorporating Undead Creatures in TTRPGs – RPGBOT.Podcast S3E28 The Undead II: A Guide for Role Playing Undead Creatures in TTRPGs – RPGBOT.Podcast S3E30 Content from RPGBOT.net Call of Cthulhu Starter Set – A Review Other Stuff Baldur's Gate Chaosium Basic Roleplaying System (affiliate link) Monstrous Races (affiliate link)  Music by GeriArt on Pixabay Closing Theme Music by Bluemount Score from Pixabay  

On this episode of the RPGBOT.Podcast, we discuss aberrations. We look at all the weirdness from both a player's and a DM's perspective, and look at ways to make aberrations interesting and engaging in your game. If you've enjoyed the show, please rate and review us on Apple Podcasts, and rate us on Spotify or your favorite podcast app. It's a quick, free way to support the podcast, and helps us reach new listeners. Check out our Best of Season 1 and Best of Season 2 playlists! MATERIALS REFERENCED IN THIS EPISODE Meeting an Ancient Aboleth – dScryb (affiliate link) RPGBOT.Podcast Episodes RPGBOT.Podcast Episode 10 – Horror Kobold Press Tome of Heroes: the Wit and Wisdom of Brian Suskind – RPGBOT.News S2E53 Journeys Through the Radiant Citadel – RPGBOT.News S2E57 Dice Math – RPGBOT.Podcast S2E92 Keith Baker on Eberron – RPGBOT.Masterclass S3E3 Keys from the Golden Vault – RPGBOT.News S3E17 The Undead – A Guide to Incorporating Undead Creatures in TTRPGs – RPGBOT.Podcast S3E28 The Undead II: A Guide for Role Playing Undead Creatures in TTRPGs – RPGBOT.Podcast S3E30 Content from RPGBOT.net Call of Cthulhu Starter Set – A Review Other Stuff Baldur's Gate Chaosium Basic Roleplaying System (affiliate link) Monstrous Races (affiliate link)  Music by GeriArt on Pixabay Closing Theme Music by Bluemount Score from Pixabay  

In this episode of the It's A Mimic! podcast, the panel of Dungeon Masters sits down and looks at a truly horrifying species bred from pure chaos: the Slaadi.  With deep links to the Plane of Limbo and a rich history from previous editions, these Aberrations can and will leave a disgusting surprise for an unsuspecting character long after the fact.  Cold Open 0:00 Opening Theme 2:57 Intro 3:19 Ad Break 9:12 Lore 10:35 Tadpole 50:48 Red Slaad 1:01:19 Blue Slaad 1:23:51 Ad Break 1:45:27 Outro 1:45:56 Closing Theme 1:48:16 Bloopers 1:48:42 DON'T FORGET TO LIKE & SUBSCRIBE! Find Us On: Patreon at https://www.patreon.com/user?u=84724626 Website at https://www.itsamimic.com iTunes at https://itunes.apple.com/ca/podcast/its-a-mimic/id1450770037 Spotify at https://open.spotify.com/show/3Y19VxSxLKyfg0gY0yUeU1 Podbean at https://itsamimic.podbean.com/  YouTube at https://www.youtube.com/channel/UCzQmvEufzxPHWrFSZbB8uuw Social: Facebook at https://www.facebook.com/itsamimic/ Instagram at https://www.instagram.com/itsamimic/?hl=en Reddit at https://www.reddit.com/r/ItsaMimic/ Email at info@itsamimic.com Dungeon Master 1:  Adam Nason Dungeon Master 2:  Kyle McQuaid Dungeon Master 3:  Megan Lengle Narrator:  Pepperina Sparklegem Written by:  Adam Nason Director:  Adam Nason Editor:  Adam Nason Executive Producer:  Adam Nason Intro/Outro Music by:  Cory Wiebe All other music provided by Tyler Gibson at https://www.instagram.com/melodicasmusic Logo by:  Katie Skidmore at https://www.instagram.com/clementineartportraits/ This episode is meant to be used as an inspirational supplement for Dungeons & Dragons 5th Edition and tabletop roleplaying games in general.  It's A Mimic! does not own the rights to any Wizards of the Coasts products. Artwork included in this episode's video visualizations is published and/or owned by Wizards of the Coast.

Snyder's Return is working with Content Creators from multiple different Podcasts from multiple different Tabletop Roleplay Game (TTRPG) systems to share our work, love of the hobby and grow the community together.This Trailer is from Adventures and Aberrations Podcast, A live Play #dnd podcast that brings the feeling of an at home game to life, Discord: http://discord.gg/Y5yPNYou can find them:Twitter - https://twitter.com/AdventandAberrWebsite - https://shows.acast.com/adventure-and-aberrationsSupport the showFind us on:Twitter https://twitter.com/ReturnSnyderInstagram https://www.instagram.com/snyders_return/Website https://www.snydersreturn.squarespace.com Linktree https://linktr.ee/snydersreturn

Changes from a normal heartbeat are called arrhythmias, and almost all of us have them. That's according to Hugh Calkins, a cardiologist and electrophysiologist at Johns Hopkins.  Calkins: Someone can be asymptomatic, it's very common to have a cardiac arrhythmia … Aberrations in your heartbeat are common, Elizabeth Tracey reports Read More »

In the wake of a year that's been plagued with book bans, book burnings, and right-wing censorship of all kinds, we're wondering: why is our American history being banned? Florida Governor Ron DeSantis' recent attempts to ban an Advanced Placement course in African American studies have us thinking about American fragility, and the drastic consequences of this censorship. Not to mention, what does this mean for our constitutional rights—matters like free speech, and the First Amendment? When the government infringes on our fundamental constitutional rights, how can we fight back?Joining me to discuss these important issues, is a very special guest (one who himself has been blacklisted!):Professor Roderick Ferguson is the William Robertson Coe Professor of Women's, Gender and Sexuality Studies at Yale University, where he is also a professor of American Studies. He is the award-winning author of One-Dimensional Queer; We Demand: The University and Student Protests; The Reorder of Things: The University and Its Pedagogies of Minority Difference; and Aberrations in Black: Toward a Queer of Color Critique.Check out this episode's landing page at MsMagazine.com for a full transcript, links to articles referenced in this episode, further reading and ways to take action.Tips, suggestions, pitches? Get in touch with us at ontheissues@msmagazine.com. Support the show

durée : 00:54:48 - La Terre au carré - par : Mathieu Vidard - La Coupe du monde au Qatar est symptomatique du désastre écologique des grandes compétitions sportives. De quoi provoquer un grand sursaut ? Pas vraiment : de nouvelles bombes se préparent. En partenariat avec Reporterre, le média de l'écologie. - réalisé par : Valérie AYESTARAY

The Sharin' Hour 10/3/22: ACQUIRED SITUATIONAL NARCISSISMAcquired Situational Narcissism and a bunch of other human/social syndromes (prosopagnosia, anyone?) examined by Sheran James of The Sharin' Hour on KX FM.

On today's show, it's been a whirlwind, but we're already 3 weeks into an NFL season highlighted by a number of unlikely outcomes, leading me to wonder; could we be seeing some upstarts here? And whose success is just an aberration? The Sunshine State is well represented this season, but Tom Brady's Bucs are only the third best team from Florida we've seen so far. Lamar, Jalen Hurts, Trevor Lawrence and Tua are the top performing QBs in the league and way too premature MVP favs; heck, even the Bears have a winning record! (Sorry Gaber.) And then there's the underperformers, too numerous to name, and we're gonna try to sort through and figure out what's for real. Plus, NBA training camps are on, the season is just weeks away, and it's time to preview the season, and giving the World Champion Warriors their due, we might as well start at the top. So sit back, the NFL has taken over our lives but we still find time to talk hoops and celebrate our Warriors and we're breaking down how it's all unfolding, next on the Roundup Podcast so let's get rolling . . .

Redundant Apodized Pupils RAP for high-contrast imagers robust to segmentation-due aberrations and island effects by Lucie Leboulleux et al. on Tuesday 13 September The imaging and characterization of a larger range of exoplanets, down to young Jupiters and exo-Earths will require accessing very high contrasts at small angular separations with an increased robustness to aberrations, three constraints that drive current instrumentation development. This goal relies on efficient coronagraphs set up on extremely large diameter telescopes such as the Thirty Meter Telescope (TMT), the Giant Magellan Telescope (GMT), or the Extremely Large Telescope (ELT). However, they tend to be subject to specific aberrations that drastically deteriorate the coronagraph performance: their primary mirror segmentation implies phasing errors or even missing segments, and the size of the telescope imposes large spiders, generating low-wind effect as already observed on the Very Large Telescope (VLT)/SPHERE instrument or at the Subaru telescope, or adaptive-optics-due petaling, studied in simulations in the ELT case. The ongoing development of coronagraphs has then to take into account their sensitivity to such errors. We propose an innovative method to generate coronagraphs robust to primary mirror phasing errors and low-wind and adaptive-optics-due petaling effect. This method is based on the apodization of the segment or petal instead of the entire pupil, this apodization being then repeated to mimic the pupil redundancy. We validate this so-called Redundant Apodized Pupil (RAP) method on a James Webb Space Telescope-like pupil composed of 18 hexagonal segments segments to align, and on the VLT architecture in the case of residual low-wind effect. arXiv: http://arxiv.org/abs/http://arxiv.org/abs/2209.05857v1

On this episode 96- Host Jason is joined by returning reviewer Kali from L.A.They talk and review the film- Cecilia aka Sexual Aberrations of a married woman- film # 96 from Jess Franco.Listen for an interesting and informative discussion about this beautiful and crazy film, and the odd experience watching it.Hear the facts on how this film was made, the stories around it, and all the cool details. New episodes drop every Wednesday morning!Support this podcast at — https://redcircle.com/the-franco-observer/donations

With the release of the adventure, Call of the Netherdeep, D&D has a few new aberrations to check out. Generally as a cohort of creatures, Aberrations probably don't get looked at as much as Dragons, Giants, Fey or Fiends. But there is plenty of interesting ideas for unusual settings, or strange and terrifying twists thanks to the alien nature of these creatures. Join us to unpack some Aboleths, Flumphs, Slaads and Star Spawns -- plus a few new creatures you've never heard of before. Welcome to Like Dragon Like Son, a podcast hosted by Jay and Jack Oatway where they discuss everything D&D, from character builds to personal experiences. Stay tuned for new episodes on Spotify or wherever you listen to podcasts. If you love Like Dragon Like Son and want to help us out, you can support us by sharing this podcast with your friends. It's the support of listeners like you which motivate us to put out more episodes, so thank you!

Spring is just in sight of our scanners, but this is as close as we're likely to get, being on a parallel course, an all. Ah well, would've been grand. Dronescape 104 YEAR: 2022 PUB: Quasigentsia TAGS: noise, glitch, drone, ambient, blends, binaural, subtle, sculpted, sound-design, fx, generated, random, lateral, parallel, cyclic, spring, dronescape, 104 URL: Persistent MIRRORS: Archive Audio | Archive Video | SoundCloud | YouTube IMAGES: Frame Grabs LICENSE: Attribution-NonCommercial-ShareAlike 4.0 International

Spring is just in sight of our scanners, but this is as close as we'll ever get to it, as we're on a parallel course. Ah well, would've been grand. Video at https://youtu.be/f5YyapTQXao

     This week's episode features Howi Spangler of the Baltimore area band Ballyhoo! They are local legends around here and have been toruing/releasing music for over 25 years now. I wanted to talk to Howi in particular for the 100th episode because his podcast “Tales From the Green Room” inspired me to start this show. He's also got a new solo album out called “Aberrations” which is a lo-fi instrumental reggae type thing that was just released. You can dowload it for free and/or use it license free for any of your projects. I featured a track called “Ghost Tour” on this episode, as well as Ballyhoo's song Mixtape at the end. Both of which you can find wherever you listen to music. Ballyhoo's next show is February 10th at the 930 club in DC with The Movement and Little Stranger. Anyway, big gratitude & thanks to Howi and everyone who's listened and supported the show so far. Links below.    https://ballyhoorocks.com   “Aberrations” Album Link  SPOTIFY LINK   “Mixtape” By Ballyhoo! SPOTIFY LINK   —   This podcast is now partially brought to you by the Music Video Accelerator course. Which teaches you how to make your own professional music videos like Boyce Avenue or Tyler Ward without spending thousands of dollars on gear, so you can post killer content every week and grow your following organically. It's the first course of it's kind that specifically teaches how to shoot on your iPhone as well. Mention the podcast for a discount. Learn more at www.musicvideoaccelerator.com  

  We judge almost everything using a 5-star rating. If we see a product, service, or company receive glowing 5-star reviews, we're much more inclined to spend our money there than with a brand with only 3-star reviews. So, how can this translate to your career? Do you want a 5-star career or a mediocre one? How can we apply the science of quality management to drive personal success and get the most satisfaction from day-to-day work—no matter what type of job you have or want, your skill or educational level, or your age—which will, in turn, improve your quality of life? About the Interview In this episode of Hilary Topper on Air, Hilary speaks with Penelope Przekop, an internationally recognized quality assurance expert who has worked with Fortune 100 pharmaceutical companies for over 30 years and author of the recently published book, 5-Star Career: Define and Build Yours Using The Science of Quality Management. Learn from Penelope how to apply the science of quality management to your personal development and result in 5-star quality throughout all aspects of life including your career. About Penelope Przekop Penelope is a corporate quality management expert, entrepreneur, and writer. Throughout her 30+-year career, she has worked with numerous Fortune 100 pharma companies, including Pfizer, Merck, Lilly, and Glaxo Smith Kline, and held leadership positions at Novartis, Covance, Wyeth, and Johnson & Johnson. She is the founder and CEO of PDC Pharma Strategy and serves as the Chief Compliance Officer for Engrail Therapeutics. She is the author of Six Sigma for Business Excellence (McGraw-Hill) and four novels: Please Love Me, Aberrations, Centerpieces, and Dust. Przekop earned a BS in Biology from Louisiana State University and an MS in Quality Systems Engineering from Kennesaw State University. She is a graduate of the Smith College Program for Women's Leadership and the Rutgers University Senior Leadership Program for Professional Women. In 2018, Przekop and her older daughter founded Bra in a Box, which has been featured in Real Simple and New York Magazine. She lives in the Greater Philadelphia Area with her husband of 30 years.     About 5-Star Career 5-Star Career: Define and Build Yours Using The Science of Quality Management provides common sense, strategic context for personally implementing quality concepts that reflect your goals as well as your own definition of a 5-star life and career. This book provides the following benefits: Explains how the science of quality management can ensure customer satisfaction, which is what the industry uses to gauge the quality of products and services. Relates that explanation to you on a personal level including how the basic concepts and components of the science apply to your career/job, the path is has taken, and can take. Challenges you to identify your authentic needs and desires following the thought process, research methodology, and data analysis corporations rely on to understand their customers. It tells you how to do all of that and provides a unique tool to help you gather and analyze the right type of data and information. Clarifies the critical role that controlled systems and processes play in the science of quality management, the role they play in the personal application of quality management, and their surprising power to ensure intended outcomes. Explains how to apply the proven decision-making methodology (used by industry) to identify the best possible process that leads to the career you deem as 5-star worthy, and to address the career elements that will satisfy your authentic needs and desire. Relays how risk-based decision making is not only key to identifying a process that ensures success, but also to addressing the unexpected curveballs that will surely come your way. For more information about Penelope and her book, 5-Star Career, visit www.penelopeprzekop.com.

This week in Dungeons and Dragons, the party rushes out of the collapsing keep and into Stonegate, only to find strange creatures are waiting for them.    We have a Patreon! https://www.patreon.com/knightsandnerds   Check out our Discord: https://discord.com/invite/kdVrP5UMB6   Social Media https://www.facebook.com/knightsandnerdspodcast/ https://www.instagram.com/knightsandnerds/ https://twitter.com/knightsandnerds   Background music by Tabletopaudio.com

We live in a world dominated by ratings. We generally prefer to purchase 5-star products, read 5-star books, eat at 5-star restaurants, and watch 5-star movies. Why then would you settle for anything less than a 5-star career? Today's guest says you absolutely should not, and offers ways to be your best self at work and in your personal life.In this HRchat episode, we hear from Penelope Przekop, a corporate quality management expert, entrepreneur, and writer. Throughout her 30+ year career, Penelope has worked with numerous Fortune 100 pharma companies, including Pfizer, Merck, Lilly, and Glaxo Smith Kline, and held leadership positions at Novartis, Covance, Wyeth, and Johnson & Johnson.Penelope is the founder and CEO of PDC Pharma Strategy and serves as the Chief Compliance Officer for Engrail Therapeutics.She is also the author of Six Sigma for Business Excellence (McGraw-Hill), four novels: Please Love Me, Aberrations, Centerpieces, and Dust and she has a new book coming out in November called 5-Star Career: Define and Build Yours Using the Science of Quality Management: amazon.com/5-Star-Career-Science-Quality-Management/Questions Include:Let's begin by understanding a bit about you. While struggling to overcome a troubling childhood, become the best version of yourself, and build a career, you began incorporating quality management concepts into your personal thought process at home and at work. As a result, you say you found what proved for you to be “the missing link” between all of your hard work and feeling rewarded. Tell me more.Why do people settle for mediocracy? Is it laziness (too much ‘Netflix and chill' time)? Is it a lack of opportunity? Is it the system keeping us down? Is it something else?Why do you believe one's career is, essentially, what we make of it? Talk to me about the concept of a person's career being a product created by their own process. Share too, how to improve that process by learning to manage all the parts as an integrated, unified whole.In your new book, you suggest it's possible for us to each clearly define what a quality career means. Tell us about that process. As part of that answer, perhaps you can explain what you mean when you explain that a ‘successful career is not just about money and that it's vital to shift one's personal philosophy, mindset, and operating system to support developing it?You stress the critical role data plays in making decisions that can produce a 5-star career. How can data guide us along our career journeys and help us to avoid impulsive leaps and be more honest with ourselves?We do our best to ensure editorial objectivity. The views and ideas shared by our guests and sponsors are entirely independent of The HR Gazette, HRchat Podcast and Iceni Media Inc.  

The battle with the mutated Hobgoblin continues, as Agon, Elleinad, and Gardin fight for their lives! As the trio confronts this monstrosity, it continually mutters dark curses in Deep Speech, the language of Aberrations. Just what does Shath'Philfgsh mean? And what resides within the pit found within the cellar in the Fortress of Volrak?

Y'a des jours avec et des jours sans. Quand on sort le soir et qu'on se fait menacer le lendemain matin, la journée passe plus lentement. Aujourd'hui on va quand même debriefer ce magnifique plateau d'humoristes Urban Comedy au Comedy café à Pigalle. Pas mal de bonnes surprises mais aussi des confirmations. Quelques bides aussi sinon la fête ne serait pas complète. Aujourd'hui autour de Yassine Belattar et Thomas Barbazan : Hugo, Amin, Hétonque et Rémi. Allez bisous et n'oubliez pas que même quand on est pas chaud, on a des frais. Alors donnez-nous les moyens de nous réveiller sur www.legrandrapprochement.lol

В новом выпуске подкаста Pan Meditat поговорим о том, как с работы одного швейцарского полимата началась история баз данных, мировых архитектурных проектов, и как наша память постепенно вытеснилась тягой к архивации. Из этого подкаста вы также узнаете кто первым выгорел на работе, когда впервые заговорили о дежа вю, и как потрясения XX века отразились на конфликте истории и памяти. В следующем эпизоде поговорим о нейропсихологическом аспекте дежа вю и аберраций памяти. Хронология событий в подкасте ~1440 — появляется станок Гутенберга 1515 — Альбрехт Дюрер завершает «Носорога». Из учебников это изображение пропадет только в XIX веке. 1545 — Конрад Гесснер заканчивает первый том Bibliotheca Universalis 1550 — библиограф Антон Франческо Дони жалуется на «книжный потоп» 1641 — «война памфлетов» 1691 — Лейбниц устраивается в библиотеку Вольфенбюттеля и продолжает дело Гесснера. Умирает в 1716 году. Начало XVIII века — бумажные деньги получают широкое распространение, но французский банк Джона Лоу закрывается в 1720 году из-за военных долгов Людовика XVI, в 1811 году австрийское правительство становится первым банкротом такого масштаба. 1882 — Ученый Вильгельм Фридрих Оствальд пишет о выгорании из-за огромного количества работы и информации 1900 — проходит Мировая Выставка 1901 — Фрейд пишет про дежа вю 1906 — Оствальд уходит из академии и начинает серию «мировых» текстов после посещения одной из выставок в 1904 году 1911 — Амундсен и Скотт отправляются на Южный полюс, по миру распространяется система почтовых адресов 1914 — Фрейд пишет про экранную память 1919 — Фрейд пишет про возвращение в утробу 1922 — помощник Оствальда Вальтер Порстман публикует стандарт бумаги DIN 476. Формат A4 мы используем до сих пор. 1936 — Фрейд снова пишет про дежа вю 1972 — Хайнер Мюллер дописыват Herakles 2 oder die Hydra 1962 — публикуется программа генерации текста Auto Beatnik 1984 — в Scientific American пишут о генераторе прозы Racter 2004 — запускается Facebook Книги выпуска Paper Machines. About Cards & Catalogs, 1548-1929 - Markus Krajewski The Server: A Media History from the Present to the Baroque - Markus Krajewski World Projects : Global Information Before World War I - Markus Krajewski Déjà Vu. Aberrations of Cultural Memory - Peter Krapp The End of Forgetting. Growing Up with Social Media - Kate Eichhorn Обложка выпуска - Yo Az Патреон: patreon.com/pan_meditat Канал в Telegram: t.me/pan_meditat

Ethical Fashion with Red Tale Moon Clothing Line Founder, CEO, and Artist, Jeanine Boubli Jeanine Boubli is a mixed media artist and creator of the ethical and environmentally conscious lifestyle apparel brand Red Tale Moon. She strives to create awareness and respect for all animals, Mother Nature, and soulful connection through her creative work. Red Tale Moon's designs' are inspired by animals she know well as a volunteer animal caregiver at a local sanctuary. She loves spending time outdoors, taking long walks by the water, and writing poetry. Connect with Jeanine https://www.linkedin.com/in/jeanineboubli https://www.instagram.com/jeanineboubli https://www.instagram.com/redtalemoon www.redtalemoon.com The Episode's Transcript Jeanine Boubli-FULL-1 [00:00:00] Jeanine Boubli: [00:00:00] I will say though, that there, now that you're here talking about being scared, there is really nothing scary about following your heart. There is something very scary about not following your heart. [00:00:17] Izolda Trakhtenberg: [00:00:17] Hi, and welcome to the innovative mindset podcast. I'm your host Izolda Trakhtenberg. On the show, you get my conversations with peak performing thought leaders, creatives, and entrepreneurs. We explore how you can innovate through creativity, compassion, and collaboration. I believe that innovation combined with compassion and creative thinking can save the world and I aim to bring you ways. [00:00:40] You can do it too. If you're enjoying the show, I'd be super grateful. If you could support it by buying me a cup of coffee, you can buy me a cuppa at buymeacoffee.com/izoldat. And now let's get on with the show. [00:01:01] [00:01:00] Hey there and welcome to the innovative mindset podcast. My name is Izolda Trakhtenberg. I'm so happy that you're here and I'm honored and happy to have this week's guests. She's amazing. You're going to love her.  Jeanine Boubli is a mixed media artist and creator of the ethical and environmentally conscious lifestyle apparel, brand Red Tale Moon. [00:01:21] So, you know, I love her and you know, you're going to love her too. She strives to create awareness and respect for all animals, mother nature, and soulful connection through her creative work. Red Tale moon's designs are inspired by animals. She knows as well. Well, she's she's a volunteer animal caregiver at a local sanctuary, but she also uses her heart and her imagination to create these incredible designs. [00:01:45] She loves spending time outdoors, taking long walks by the water and writing poetry. Jeanine, I am so glad that you're here. I'm honored and thrilled to talk to you about your ethical stance on what you do and the artistic drive that [00:02:00] helps you help the animals of the world. Welcome to the show. [00:02:03] Jeanine Boubli: [00:02:03] Oh, thank you so much. [00:02:04] I'm so happy for this opportunity to share. Thank you so much. I'm [00:02:09] Izolda Trakhtenberg: [00:02:09] so excited. So I. The thing, look, anybody who knows me for any length of time goes, yes, she's, she's an outspoken vegan she's plant powered, blah, blah, blah. Right. I I'm pretty far out with that. So the question I have for anybody I talk to about, about sort of being ethical, as far as how you interact with the rest of the living world is what, what got you started? [00:02:36] What, what was the turning point where you said I'm going to choose a path like this? [00:02:44] Jeanine Boubli: [00:02:44] Well, I didn't, I don't know that I consciously chose it. I feel like it chose itself through, you know, my soul, if you will. I started, you know, I was vegetarian for years and I started volunteering as you [00:03:00] know an animal caregiver at a local sanctuary That happened shortly after too challenging, having two challenging years of my life, my father was sick. [00:03:11] I moved out from the city. I came out to long Island to help him. I didn't realize how much that affected me. Long-term and so after the house was sold and I was like, okay, you know, where am I going to know? Like, I'm not going back to Manhattan right now. And my life was kind of up rooted in a sense my heart was, and yet. [00:03:33]It provided a, all, it also provided like an open an, Oh, well, an open space, like a big, vast bit of land, you know, and my future, because I didn't really know which way I was going to go with my future. And what happened was a neighbor where I moved to a neighbor said to me, one day she saw how I was, how I was with her dog. [00:03:53] She said, she need, you love animals so much. You would love this place. And you know, they've got a cow and they've got [00:04:00] goats and sheep and blah, blah, blah. And I said, Oh, well, I grew up here years ago. I never heard of it. And so the next day I was Googling and I've been volunteering there ever since. And so that was, yeah, that, that, that this experience, that's still part of my life and will always be a part of my life because it's my heart. [00:04:23]Really. Opened up my heart healed my heart, calmed my mind and inspired me to create or to get just being like you just being with the animals and their environment. I did not want to be with people at that time. No, I'm fine now, you know, but I just needed the quiet and just to be in a, in an environment now, all of the animals are loved. [00:04:45] They're not, you know, they're, they're fortunate, they're loved and they're cared for and to be with them and witness their friendship and their wisdom. And when one of them is sick and how, you know, the other ones are there for [00:05:00] them it's just really, really beautiful. And so that's what started to inspire me to. [00:05:05] Go ahead and use them as the subject matter for artwork. Because once again, I was kind of reborn, if you will. Instead I, they opened my heart and with my hearts opened, then I wanted to create, again, it could be in creative, it has always been inside me, but there was, I just kind of closed up like a closed fist. [00:05:24] I, you know, just, but then they, they, they, it was them, it was being with them and their love and their sweetness. That opened that part of me up again. [00:05:35] Izolda Trakhtenberg: [00:05:35] Yeah. Wow. I, you know, it's so it's wonderful and it's inspiring. And I know, I know other people who have that sort of connection and realize it's worth. [00:05:52] And you took it, you took that connection and you decided to work on behalf of them, these [00:06:00] wonderful critters, these wonderful beings we share the planet with when you started, when you started that, that process of like, okay, I'm good. I'm inspired by this and I'm going to do it right. Can you talk a little bit about what happened inside you that first time you sat down or maybe you weren't sitting? [00:06:20] I don't know what your process is the first time you, you went okay. That's it. I'm going to do this. I'm going to create. Was it a design. Oh, yes. Yeah. So the thing that, and how was your, how was your mind and your heart, where were they when you were doing it? Oh, [00:06:36] Jeanine Boubli: [00:06:36] well this is a, this is a bit of a story, but I'll tell you. [00:06:41] So I we had an Adobe user group on long island. I was the co co-manager of the group and the manager, Sharon. She said to me, one day I was at her house and I remember exactly where we are now because he brought me back there and. She said, you know, I would love to get our members more involved. Can you think of [00:07:00] anything? [00:07:01] And I wasn't thinking I was just responding, you know, when things just come out of your mouth and I said, well, we have so many photographers in this group. Why don't we have them take some pictures? There's pictures of textures, there's textures and everything. I said, why don't we have them take some pictures of textures and then apply those textures to another image and share. [00:07:26] And she said, great idea. Can you come up with something? I said, sure. So lo and behold the next day I, like, I already knew that I w I wanted to use something that was current. I am a creative person. There's like, there's many things that they can create, but I wanted to create something from something that was current in my life. [00:07:48] Something that really meant a lot to me. And that's the animals something from my heart. So I said, okay, I'm going to just, I'll go look through some pictures, you know, of the kids. And I took a picture of salt. She is a white [00:08:00] sheep. And then, you know, just like what somebody's cooking and they don't measure, it was kind of like, you know, somebody's painting and they're splattering the paint. [00:08:08] I was taking some other images, like even a blurred image of an image of some branches, if you will. I did not know what I was going to create. I was just gathering material, whatever felt, something, you know, oh, I'll put this in a layer. Oh, I'll put this in a layer. And then maybe it must've been almost eight or nine hours afterwards, just zoning with Pandora. [00:08:30]I created this. I an art piece with the salts and I shared it with her. She goes, Oh my God, I love this. This is great. Well, what happened was, you know, we had this I couldn't show the process to the people, the, you know, to our members because it was a creative process. I was zoning, you know, it wasn't just apply a filter and, Oh, it looks like this, or, Oh no, this was, you know, masking and taking out and putting in and just, you know, create, create, create a bliss if you will. [00:09:00] [00:08:59] And it had, it just, it was like a co-creation and one thing led to another and I was a member of long Island, visual professionals, a lot of creative people and a woman, Linda from like the Huntington arts council came one night and she spoke about having there was an art an art show. They were going to have a juried art show. [00:09:23] And I had not entered a show in a long time. My creativity, like when my father was sick, I wasn't creative afterwards. I wasn't creative until I was re awakened. If you will, with the animals love and had my groove back. My mother had passed, you know, years before. So there was another time when I kind of closed up in that way. [00:09:45] And it all, it all goes into the creative, whatever we create though, whatever, even the parts, the times when we close up that's also in there and that's important too, that comes, that comes along. So basically she said we are going to have, you know, we [00:10:00] have this this art show coming up and I wanted to share if anybody's interested, it's about you know, you can have photographs, but they need to be enhanced digitally or any kind of digital art. [00:10:11] Lola love a lot. And it was like, somebody was tapping me on the thigh. Janine, you've got to do your art. You've gotta do your art. You've got to, you know, you've got to do this now. It was talking straight to my, she was like, I felt like she was talking directly to my ears amplified. And so I said to her afterwards, oh, I would really like to, you know, get some more information I'd like to enter the show. [00:10:33] And so she said, great, do you have a business card? Well, lo and behold, I had created a square business card with salts picture that fine art piece from the Adobe user group program, you know, from the program from that project. And she looked at Saul's picture and she said, oh my God, I love this. This is great. [00:10:51] And you should, you should enter this. Well, I entered salt, salt ended up winning first place. And that was the beginning of [00:11:00] okay. Universe is like, go, go, go, go with, you know, and, and so that took, I mean, I don't want to. Take too much time talking about it, because then like, there was a series of different things. [00:11:12] Like I created a line of no cards and then one day this woman said, Oh, yes, I love these pictures. They're nice. And I thought to myself, none. And then, and then they're no, no, no. These are not pictures. These are living beings. They might be a nice, you know, there might be a nice picture. Okay. Yes. I could say yes to that, but no, there's so much more to them. [00:11:34] And so one night before I had an opportunity to share a table a local farmer's market if the war just like worse and kept flying out of my fingers, I said, no, no, no, I've got to go ahead and share more. And then I, you know, I cut on, cut up some paper, put them in to sleep so that people would see, okay, this might be a nice picture, you know, and there's a nice animal Lavella, but there's so much more. [00:11:58] And then they would turn [00:12:00] over the card and read what I had to share. And I saw it right with my eyes. They resonated, some people resonated more with the words than they did with the animal, which was, you know, a personal connection. So however somebody is going to Feel a personal connection, whether it's the words or whether it's the images that's the, that's the whole intention, a personal connection makes things more meaningful to us. [00:12:24] So therefore we can share in a different way or maybe, excuse me, change certain choices in our life so that we don't cause any harm on really, you know, not unknowingly, but we can change, you know we can change and make our world a more compassionate place for all the baby. And there's one more like I, one more thing along the line of how, you know, there's like, it's almost like a spiderweb a divine a divine weaving of interrelated, [00:13:00] synchronistic happenings, or symbols, or meet somebody. [00:13:03]I ended up having some. I didn't have red tail moon. At this time, I ended up having some of my prints at a local nature preserve. And now there wasn't a lot of traffic, people were there only on the weekend, sometime a few hours, but it didn't make a difference. I knew that it was up to, it was my cart. [00:13:24] Like it was up to me to just show up and show, show up and share and however, whatever, if one person sees something and they relate to it and it makes them open up their heart or they enjoy it, or they might see something in a different way, then, then that's okay. If a million people see it, same thing. [00:13:43] It doesn't, you know, it's, it's about going ahead and put it showing up and putting it out there. And one day the woman said, you know, I need a, I need a bio from you so I can put it with your work. And initially I kind of felt you know, like it's like like a child or a teenager. Oh, I [00:14:00] don't want to fill out that form. [00:14:01] Right. I felt that that, that, that conditioned response, like, oh God bio. And then I thought for God's six Janine, get over yourself. This is your bio. You can write whatever you want. And so I did, and the word started flying out of my hands. Once I gave myself that freedom and that, you know, permission, yes. [00:14:24] Permission and the worst flew out of my hands and instinctively, or maybe it wasn't extensively. It was like something that was tapping on my shoulder, but it wasn't a physical tap in my, it intuitively something that peg. Go ahead and put a picture of one of the kids in the bio. So I looked and then I just went ahead and I put, I put on pepper, she's a black sheep. [00:14:48] She's very beautiful girl. I put her picture into the bio and then I wrote the bio and then I kept hearing the words over and over again. And I will just read [00:15:00] the very last part of the bio. And then we came like, cause I know I'm talking a lot. This is long, this has been quite a journey. So I didn't know I was going to have an apparel line. [00:15:14] I just, you know, I didn't know any of these things. I just knew that I know, I know what I knew more than anything. I knew who I loved and I love, I love the animals and, you know, love is the strongest. So at the very end of the bio, I wrote, this is my, my Pepper's picture. Be someone who cared. Be someone who shares compassion for all living beings. [00:15:40] If your heart is not open openness, you may be in for a joyous surprise. I am no different than you. I love my friends. I cherish a safe home, a sound, sleep. The music of the birds look at me and then the equal sign on the upper right of the keyboard. I [00:16:00] swear, I swear. I swear was popping out of the keyboard. [00:16:03] Look at me, I'm a of wards, a flying out of my hand, look at me, boom, equal sign, see yourself. And that was it. And then I knew, I CA like I knew that was like everything. And in that little bit, and I said, okay, good. Here's her bio. And then I kept hearing those words over and over again, and I was sleep. I'd wake up tossing and turning. [00:16:28] Look at me, see yourself. And I go ahead, go for a walk. Look at me, see herself in the shower driving. I was like, okay. I go, I have my hands open. You know, like with somebody very expressive with her talking, I'm like, okay, all right, I got it. I'll create a product. And that was, that was the beginning of knowing that I needed something that wasn't just not just, but something additional than a print on a wall that maybe five people will see it, or 50 people were. [00:16:58] I needed something that [00:17:00] was going to be seen so that they were seeing the way I was fortunate to see them and know them. Yeah. [00:17:10] Izolda Trakhtenberg: [00:17:10] I love that so much. And I love that statement. Look at me, see yourself. So the, I guess the question is, do you have clothing lines with pictures of some of these beautiful. And do you have the quote underneath? [00:17:26] Oh, yes. Yeah. Okay. I need that. I need them [00:17:31] Jeanine Boubli: [00:17:31] pepper. Pepper was my first, you know, and Pepper's picture. And it says be someone who cares, be someone who shares compassion for all living beings and on the bottom. Look at me, see yourself. And I put my TM symbol there too. [00:17:47] Izolda Trakhtenberg: [00:17:47] I love it. I love it. That is. [00:17:49] So I'm going to max out my credit card. I can tell. So, so here's the thing you, you must. You must have [00:18:00] faced challenges and opposition to doing something like this. Right. And so, so I'm wondering if you can talk a little bit about what those challenges were and how you navigated them, because it's such an important process to go through and your wisdom can really help someone else who's going. [00:18:19] I want to do this. I want to live a more compassionate life and I want to put my money where my mouth is. Right. But I'm scared. So if you could talk a little bit about the challenges of that and also about your strategy, how you did it. I would love, love, love to hear it. [00:18:35] Jeanine Boubli: [00:18:35] Sure. I don't know that I had a strategy in my head. [00:18:38]Like I, you know, I got like an outline. I'll do this and then I'll do this and I'll have a business plan. I wasn't. That's not really my, you know, my strong point. I will say though, that there, now that you're here talking about being scared, there is really nothing scared. Scary about following your heart. [00:18:56] There is something very scary about not [00:19:00] following your heart. And if I did not follow my heart and say, like, after save, after my father passed, and then I healed and I started volunteering and I work for XYZ company and from, you know, and I was there from seven in the morning, you know, from commuting or whatever, till if I did not go ahead and honor my art and took and took the safer more supposedly like reliable, dependable income coming in path, I would have lost myself. [00:19:39] Because for years, I've always wanted to do something with my creativity. I was always creative. I always believed in it. And I it has not, you know, I, I know, and like, I love my parents and you know, it has nothing to do with anything they did. It's just I was brought up, you go ahead, get a job. You work up the [00:20:00] corporate, you know, you work up the corporate ladder, you make the money or you make the do whatever. [00:20:04] And then you do what you love when you have time. Or, you know, it's just they always supported my creativity. They did. It's just that maybe it wasn't as safe, you know, and the parent wants a child to be safe, which means pay your rent. Pay and take care of your responsibilities, right. And go on a certain path. [00:20:26] But no, no, no. Sometimes we just all have to follow our own path. And so I would say that the most scary thing is not following something that's deep inside somebody. I that's what, that's, what, like, that's what really is happening. Like that's, that's that it means everything. I will say that you know, resources, obviously finances and things. [00:20:49] It does cost money. It does take time. There's trial and error. I started off with a print on demand company. And then if the [00:21:00] shirts were not organic cotton and for some reason when somebody said to me, well, if you're, I'm all a bit kind of like an attitude, well, if you're all about the environment, what about organic cotton then in and out? [00:21:10] And I said, Well, that's what I really wanted. And this woman from like SBA, small business administrative administration, she said, well, then why aren't you doing it? I said, because I can't find it now. Now it's a couple of years later it's more readily available, but still it's not as available. If somebody wants to do print on demand, which I'm not doing, everything's custom right now. [00:21:32]It is more, it's more expensive. And yeah, so there's like, I, I, I've learned a lot of things. I don't know that I've made it easier for myself with some of my choices. I think some of the, like if I, if I had created if I just went ahead and pick the plain cotton shirt and did it the certain way, and didn't really care about the environment or whatever, or did this or that. [00:21:57]Because, you know, cotton, it's not that cotton, so [00:22:00] so-so whatever, I'm not saying about cotton, but if I went ahead and maybe did what seemingly was a simpler way, seemingly simpler, I don't know that it would have really been a mirror of my values at the deepest level. And I was like, you know what, I'm not a kid. [00:22:17] I've got to, not even if I was young though I wanted to stay true to myself and true to the product because it's more than a product. It's a hard, it's hard first, a product second. [00:22:31] Izolda Trakhtenberg: [00:22:31] And you know, what's interesting talking to you about what you just said is that it's evident in talking with you for even just a few minutes. [00:22:39]It's evident, it's evident that you put your heart first into your product. And I think, I think, you know, this is going to sound kind of Calculating. And that's not really what I mean, but I think people resonate with that and the people who need to be your customers will find you because they're looking for the same thing, you know, they're looking for that same [00:23:00] thing. [00:23:00] And so the question then becomes for me, how do you get the word out? I mean, yes, you're on this podcast and I'm glad to get the word out too, to the people who are listening, but how do you get the word out that you have a heart-centered business that is all about, you know, supporting and being kind and compassionate to the beings who share the planet with, to, to the other animals on the planet? [00:23:23] What. What do you do? And, and how does it work for you? Well, [00:23:28] Jeanine Boubli: [00:23:28] I honestly don't know. I need to do more. I do, I do need to do more. We were because it's not a cop out because of COVID, but you know, it was always nice to maybe be involved with pop-ups. We were involved in a couple of pop-ups this way I could speak directly to the people whoever was coming by and share some of the story. [00:23:50] And or even like, just to witness people's reactions and hear what they had to say and hear their experiences with different either [00:24:00] animals or life or what they resonated with and have them share. I do miss that we were in three fashion shows. We were at a vegan fashion show. And yeah, I can remember driving to Atlantic city and it was like such an exciting thing because it was my first fashion show. [00:24:20] And I had my flip flops on my hair was like a mess. And, but I had the, I had the products and it ended up, I ended up having no children models, you know, male models and, you know, women models. And it was just such a wonderful opportunity. And I, I remember that at the end of like all the different designers clothing, when they were presenting them, the The founders or whoever created the clothing like me and the other people, the other people in, I, they needed to go, you know, behind the models, you know, and everybody walks down like this little runway and they, they clap their hands and whatever. [00:24:59] And I [00:25:00] still have my flip flops, [00:25:06] like five in the morning at four in the morning, but I didn't care because you know, when you're following your heart, it's like, all right, this is an opportunity. All systems go, who chairs, you know, there's no time to care about that. You just want to make sure that, you know, the kids are, are, they, they liked their shirt, like, like it fits right. [00:25:23] And they understand, they understand who they're representing. It's not just a shirt. It's, it's a, it's a heart and a soul. And they know about the animals beforehand and they understand the words behind them. If they're wearing something with words. So the fashion show, and then so, and then there was one at national geographic, so I'm just. [00:25:42] In off to the side for a second, because that was a good opportunity to, to get in front of people. It was a sustainable fashion show at national geographic and yeah, in DC, no, no. In Manhattan times square, right in times square, that was a big deal. And very exciting. [00:26:00] And cat who put it together an amazing woman. [00:26:03] And she actually gave me one child model that I didn't know, I was going to be able to have a child wouldn't, you know, as a universe would have it. I had a perfect shirt, actually. He wore assault shirt the fine art piece of salt in his thighs at home. So I could bring it to the fashion show. Like the next day it was just the way everything worked. [00:26:22] And that was a wonderful opportunity to get in front of people who might not all be for the, you know, who, who, who. That that might not love animals or might love animals, but not, yeah, I love all animals or maybe they love all animals and they have never known as she personally, or a rooster or a goat, you know? [00:26:45] And there was this big, huge wall and the pictures of the kids were blown up on this wall. So there was no way that somebody couldn't see them and then, you know, the models, you know, they, they were great. They were amazing. So, so that [00:27:00] was a way of bringing them their message and red tail moon in front of people that might not have been searching for it Googling online. [00:27:12] You know? So that was a, that was a, that was a great opportunity. And also it was a sustainable fashion show. And what we brought to that I believe is the concept of ethical treatment of all animals into the sustainable conversation. Talk about that after, but that was very, very important because I that's, that's, that's not always the case. [00:27:33] There's a little bit of a disconnect there or oversight. And I know that well we both know that I've got to now like reach out to press and do those pitches and get it going and get it out there because it's not going to happen if I don't start knocking on more doors, you know, and it's getting, I, you know, getting to that point, I have met people through you know, some great conversations on [00:28:00] clubhouse and connecting with some people that I've wanted to connect with and that well know or now know what I'm about and what red tail moon's about. [00:28:11] Where if I didn't go ahead and knock on the door, open the door. Or open my ears or speak up in these conversations. They, you know, how are they going to know? [00:28:23] Izolda Trakhtenberg: [00:28:23] Sure. And that that's the thing is then you meet people who can elevate what you're saying and get it out to a bigger audience, which [00:28:33] Jeanine Boubli: [00:28:33] it is, it has for sure. [00:28:36] Yeah. Aberrations. I would, I there is a woman who's going to write about ethical, I mean, ethical, she's going to write about, she has she creates vegan handbags and Rachel, moon's going to be one of her ethical crushes that she writes about. So yeah. So that's nice and more of that. And I would love to connect collaborate with a large company. [00:28:59]I believe [00:29:00] what a red tin moon's all about and the quality of the designs and. That everything about it is worthy of that. And I think that a company whose heart isn't in the same place will appreciate that. But I do think it has to be all about heart a connection of heart, because those are the strongest connections. [00:29:20] No, [00:29:21] Izolda Trakhtenberg: [00:29:21] for sure. And you know, I feel like Stella McCartney, if you're listening, you should. Yeah. [00:29:27] Jeanine Boubli: [00:29:27] Yeah. Call me, here's my number. [00:29:33] Izolda Trakhtenberg: [00:29:33] So something about the big disconnect, and this is sort of the sustainable conversation with respect to how we, how we treat the animals we share the planet with I'm. Can you, can you talk a little bit about, more about what that means and, and what the importance of it is as far as bringing ethical treatment of all animals to the discussion. [00:29:58] Jeanine Boubli: [00:29:58] Right. It's very, very [00:30:00] important. I just recently, you know, Hermes they, they now they just, they started advertising about launching a new line of bags of you know, created from mushrooms. Right. And so this was, I saw, I saw this on LinkedIn. I already heard about it and I had to speak up because, okay, it's great. [00:30:23] If somebody is trying new things and it's better for the environment, that's great. At the same time. At the same time, there are crocodile farms, thousands and thousands, and thousands of crocodiles being bred. In these swampy looking pools or whatever. The, I, you know, I don't want to be pointing my finger at anybody. [00:30:44] This is just, this is the truth. This is the truth. I'm not making this up. And nobody brought this up in this one discussion. I said, well, this might be great, but at the same time, what about all of the crocodiles? And then they're going to be like skinned [00:31:00] and to be somebody who's back. So does this mean that this company is going it's cha has a change of heart? [00:31:07] So which I don't want to speak for somebody because I'm not that company. So, you know people can make their own judgments and I don't want to be judging anybody just, but at the same time, no judgment and speak up for those that can't speak up for themselves. So I needed to speak up for the crocodiles. [00:31:26] And so the disconnect like, you know, there's. You know, people, not people, but this sustainable conversation, I initially thought, okay, sustainable people care about the environment and they're talking about the ocean, but they're talking and they're talking about, you know, plastic and garbage and wait a minute, wait a minute. [00:31:49] What about the fish? What about the Marine? You know, the wildlife in the sea. What about what about the sheep and the goats and the hens and [00:32:00] the roosters and you know, like, and the ducks and the pigs, like what, doesn't somebody, you know, like who I know people do care. Why is that not being brought up in the discussion? [00:32:11] And the thing is what sustainable people are concerned about the environment and global warming. And the truth is animal agriculture is. Horrible for the environment. It's not even a little bit. It is extremely hard. Horrible. There's excessive CO2 production methane. Let's see. Yeah. I have some notes here just to make sure that I pronounce everything correctly. [00:32:37] Methane nitrous, oxide production. There is top soil, you know, like the soil, they, they feed well, there's also like deforestation there's the water supply. There's the tanneries like if you know, the, the Tanner is once somebody has like weather light, leather cows, [00:33:00] a cow skin there's chemicals in that they, they feed that the innocent animals, they feed them all kinds of chemicals and hormones to fatten them up, to keep them healthy until they. [00:33:14] They killed them. They kill them so they can become somebodies meal. And then that's, I mean, and that's the end of that. So I don't know if I went off on a tangent. They're like there we've been brought up. I mean, I did not know certain things growing up as a child. I did not know. I mean, I became vegetarian pretty much during college. [00:33:34] Well, I gave, I gave, I didn't give up. I gave for E a T horrible word. But I'm not, I'm not, I'm not eating, I'm not eating that anymore. I, I wasn't, I wasn't vegan then, but I just, something was wrong. I just like, I didn't want any part of it. And I we've been brought up. We've all been brought up with advertising. [00:33:57]The, like [00:34:00] the cows. I mean, how many, how many people growing up or kids grow up thinking, oh the cows, the cows milk is for its baby. I don't think a child thinks that. I know, I didn't think that I just thought that ignorance or not knowing as a child, a cow produces milk growing up, you know, the, those parameds you know, make sure you have your milk, make sure you have your protein, the meat, the meat that, this, and the, that I could say, if they knew better, who created that shame on them, shame on them because that pyramid didn't help anybody at all. [00:34:35] It didn't help the animals. It didn't help the environment and it didn't help people's health, if anything, it harmed every, all of them. So now that we know better, we can make better choices. So with a sustainable conversation whether it was at like the fashion show or a group that I was part of there sometimes there were people that just didn't want to hear it. [00:34:58] They didn't, or, [00:35:00] or, and some people didn't care and some people here, but they weren't going to change for whatever reason. I'm not here to go ahead and tell somebody you've got to do this, or you got to do that. I'm all about Nope. Live your life. Freedom for everybody. And that includes also freedom for the animals. [00:35:19] And it means freedom, like cruelty free don't cause any harm to anybody it's like it's, it's causing harm to them. It's actually causing harm back to the people because of you know, the environment and it just, it's not healthy. It's not healthy for them. And yeah, I could go on and on and on. I don't know. [00:35:39] Did I go off on a tangent? [00:35:42] Izolda Trakhtenberg: [00:35:42] I know you didn't go off on a tangent. I think, I think that it's such a huge topic and obviously one that you're so passionate about and one that I'm passionate about too, that, that there's so much to cover in a question like that, that it's not a tangent. It's more like, and then I can plumb a deeper depth and go [00:36:00] even further and talking about this is. [00:36:03] It sometimes feels to me like, like you're screaming into a void because so many times I've had a similar conversation with someone who tells me, well, we have canine teeth, therefore we must, you know, and I'm like, you know what, quite frankly, those canines, you know, Silverback, gorillas have much bigger canines than be doing that. [00:36:27] So, no, that's not a valid argument, but, but at the same time, there is, there is this feeling that I get, that there is a machine, a marketing machine. And, and I'm sorry if you're a marketer and you're listening to this, I have nothing against marketers, but I feel like some of the really big companies have marketing machines behind them that make things that they put things out that make you think like doing what they say. [00:36:56] Yes. The only way, you know, and so, [00:37:00] so that's why, when I'm asking you these questions about Redtail moon, I'm talking about, I'm talking to an entrepreneur, a business owner who has chosen consciously to do something differently. And so then I start to wonder, how do you, how does any small business owner go up against such a, such a, a behemoth of, of marketing as, as something like animal agriculture or, or, you know, and we even saying that, honestly, shouldn't eat like saying animal, the slaughter of animals for human consumption, you know? [00:37:39] So, so, so, so. So when we look at that, how, you know, how do you do that? What is your process? I'm probably gonna, I have to be very honest. I'm probably gonna lose a ton of listeners with this episode, but I think it's so incredible. [00:37:52] Jeanine Boubli: [00:37:52] Not, I hope, I hope not. I hope if anything, you get more listeners, because I hope that whoever might not want to hear [00:38:00] what we're sharing right now, maybe just some maybe because it's shared from our hearts and not to go there's no, it's not intentionally pointing fingers at anybody. [00:38:15] It's an awareness. It's an appreciation. It's coming from a bigger space than you or from me. It's coming from a bigger space is coming from what needs to be said, what needs to be shared. And it's the people that are not aware yet or who don't care yet, which I I'm listening to. I'm hearing myself now, which is like that. [00:38:42] Perhaps we'll benefit even more from, you know, the, their, their, their lives will expand. Their heart might expand there. They may have more, they'll have better health. I mean, unless they eat all those yummy, delicious vegan treats and that's, you know, cause there's so many options, [00:39:00] but , it's, you know, even on like the energy level, M O God, to think to, to think that I ever wanted. [00:39:11] It's just like, it's, it's horrifying. If I think that, I mean, as a child and not knowing there was the disconnect and just nothing looks like what it is and the supermarkets, it's all like, It's all like a lie, you know, say it's a cow or say, this is a, you know, just see the eyeballs here are the screams. [00:39:34] That's every, every single living being you and I, and everybody listening, we all want, it's like this, we all want a safe home. Right. We that's something else. I didn't share this. I don't know why it kind of came up now, but it came up. They all want to say Paul, they're all like, I mean, it's more comfortable to be a peace, right. [00:39:53] Then, then anxiety around or intense things going on. We all like to be with our friends, you [00:40:00] know, real friends, somebody who gets us at a deeper level to share, or just even like, just, just enjoy a breeze on a warm day. Like I've seen the headlines, you know, their friends and it, little warm Breeza, that's it. [00:40:11] That's all they need. How beautiful is that? It's they're no different. They are no different than us. They are no different, they look different. I think some of them are probably cuter than us definitely care. And I may, you know, I mean, if I was called a, you know, like I brought this up the other day with somebody, even the English language, like, you know, the, the how, okay. [00:40:30] So we're talking about the big companies and advertising and things and marketing. So, I mean, maybe it's not just the English language language and the terms use including animals. Oh, it's a pick style or Ooh, you kill, or, you know, don't be chicken, like, excuse me. But I don't really like, because I don't like that C word either. [00:40:54] I like hens and roosters because I associate C with the store, you know, people eat [00:41:00] back. But the thing is if somebody called me a C, H I C K E N, or a hen or a rooster or a pig, I would be honored. Because there's no more like, genuine than that, you know? [00:41:13] Izolda Trakhtenberg: [00:41:13] For sure for sure. I actually have taken, I have a huge list that I've been keeping for years now of animal metaphors that I've turned into vegan metaphors. [00:41:26] So, so, well, the, the, I don't have a dog in this fight has become, I don't have a pie in this contest. So things like that I've gone through and I've, I've done so many of those. Let's see killing two birds with one stone has become petting two cats with one hand. [00:41:49] Jeanine Boubli: [00:41:49] So I have this huge list [00:41:51] Izolda Trakhtenberg: [00:41:51] because it is, it is about awareness, I think. [00:41:54] And that's something that I'd love to talk with you about is this notion of increasing awareness, because with [00:42:00] these sayings, you know, when I say, when I say to someone, well, I don't have a chili in this cook-off and I go, wait, what? And I'm like, yeah, I don't like to say, I don't have a horse in this race. [00:42:09] I say, I don't have a chili in this cook-off or I don't have a PI in this contest. And so people go, that's really odd. Why do you do that? And then I explain and they go, I never. Thought of that. And you know, the horrible one for me is more than one way to skin. A cat has become, there's more than one way to eat a potato. [00:42:29] And I love the, so that's what I've done. And so the question is for me to you is raising awareness. What do we need to do, do you think, because I do, I'm a, I'm a communicator first. And so for me, it's language in one way or another. And so I decided to do these vegan metaphors instead of using the animal cruelty ones. [00:42:52] And so, so what is, what do we do? What does someone who is who's a creative in this way that you are, what do [00:43:00] you do? How do you have those conversations? Is it that you let them see the art and then talk about it? Or is it. Is it a push from you? Like, okay. I guess the question I'm asking is, is it more of a push out to people or is it more of a pull in for them to get curious and then come to you? [00:43:17] How do you do it? How do you have those conversations? I think [00:43:19] Jeanine Boubli: [00:43:19] it's both because I, sometimes that conversation happens even if say I'm in the grocery store and I'm not wearing a red tail moon shirt, or I'm not at a place speaking it out, red tail moon. Somebody might be at the, you know, they're at the checkout and you know, they're smiling, you know, some people, most people smile at each other. [00:43:40] Well, now we have, you know, masks on. So you can't tell they're smiling, but you can tell a little bit from somebody's eyes and you know not that I want to have this reaction, but it's very difficult being in supermarket. Sometimes I consciously avoid certain miles should go ahead and, you know, somebody. [00:43:56]Yeah. You know, like at the checkout somebody said sadness [00:44:00] to some, to me. Oh, I am, you know, I'm smiling under this mask. And I say, Oh yeah, great. You know, hope you're having a nice day. And if I happen to see a piece of my friend's body it's not funny at all. It's kind of horrified in their card automatically. [00:44:15] And it's unconscious. I'm sure that I've got this, not wanting to offend them, but it offends me, but I don't want somebody else's actions to offend me, but it does. It's, you know, it's like somebody's child, you know, if they, if, if there was somebody's child in there, they would, they would understand. And then they might say, because I wasn't happy. [00:44:38] And only a couple of times Oh, is there something the matter? And I said, well, I have to him, you know, I happen to love all animals and take this from heart. That's like, That's my, that's my part of my friends, Bobby in there. And so you know, I hope you enjoy your day. I mean, what am I going to say? [00:44:57] But with the shirts, you know there's a strong [00:45:00] message in there. The reason I did not consciously say, oh, I'm going to, well, pepper was the first, you know, and she had a message of compassion and then I wanted more messages of compassionate. But I also used salts our piece from that was from the beginning, right from, you know, what the adult the Adobe user growth and that it kind of came together. [00:45:23] It didn't consciously come together. It came together and it's like, it has a life of its own if you will. And I saw that I had messages of compassion and people could connect with the animals by reading a message of compassion. They don't mind the messages, don't say You're a horrible person because you're eating my friend. [00:45:42] I got not going to do that. Who am I to judge? I I'm in a, who am I? I mean, I'm not missing whatever. I'm human too. And I didn't know any better before. Cause I think if I did, I think I would have changed. I would hope I would have changed, you know, and then fine art pieces, artsy pieces that [00:46:00] somebody might resonate with because it's artistic looking and it's pretty and there's underlying intention of connecting with each animal through an art piece as well. [00:46:13] And then there's the messages, you know, there's original poetry. And then there's you know, the bold text text is a bold statement, like the ethic L that's also, you know, text as a bold statement. So there's different ways through this. Different designs of connecting with different a different audience, if you will. [00:46:32] That, that's what I hope. That's what I hope. You know, so yeah, so other ways I know that, but when I'm at, at, when I'm at the forum where I volunteer, which is a sanctuary now it was a dairy barn years ago. When people come and visit sometimes, you know, they, they might see, you know, they might come a few times. [00:46:53] They might come more than a few times. It might be their first time. So if I'm there and I'm able to, I like to share a little bit [00:47:00] about the animal's personality. Definitely, definitely, definitely get, have them get eye level, like we have this amazing Turkey Liberty while we all the, all of the turkeys are amazing. [00:47:09] And this little girl was visiting with her parents and I said, oh, come over here. You know, you can, you know, I'll have you meet, you know, Liberty and. So the little girl, like she stabbed me in there, but you know, Liberty of course is a little bit shorter than a little girl. And I said, you know, and I was already crouched down. [00:47:26] I said, you know what, why don't you all crouch down? So we're all at the same level. And then you can look right into her eyes. And then a little girl started going. [00:47:40] I said, you love her, don't you? She goes, yeah, I don't know how happy her parents were if they were going to have whatever for dinner or whatever, but you know what she connected. And so, I mean, in other places, you know what I feel like it's, I think like for you too, it's where everywhere we go, you know, [00:48:00] [00:48:00] Izolda Trakhtenberg: [00:48:00] it's an opportunity for sure. [00:48:02] I think, and yet the thing is for me, like I, until I, until I became a vegetarian and I will save that story for another day, I think I've done a podcast episode about it. I. Excuse me. I had a lot of animals. I have to admit that. Yeah. And, and I, and you know what, I can feel bad about it for only so long because I think feeling bad about it for me anyway, is a, it's a waste of energy because I did it, I accept it and now I can do better. [00:48:34] And I think that's a lot of what this is for me, you know, except that you are capable of what you did resolve to do better and then act on that resolution. So when you do that, when you, when you yourself resolve to do better, whatever that means for you, what forms does it take in your daily life? [00:48:56] Jeanine Boubli: [00:48:56] When I resolve to do better by me. [00:48:59] Well, just like [00:49:00] what you said, you know, not to, to not rehash certain things, 'cause it doesn't, it doesn't change anything because our paths, I mean, I eat animals as a child and as a teenager I wish I did it. I really do wish I did it. But I did and I wasn't as conscious of certain things. But then I became, and then I changed. [00:49:20]The past is really over for, I mean, yesterday and any day before those days are they could be great memories or not great memories and they're not our today except for what we choose to bring with us. So I can catch myself in certain thoughts sometimes. Or, oh, you know, maybe I should've done this or I could've done this. [00:49:42] Or even with red tail moments, like, oh, I spend most of my resources, like, excuse my language, but. Can we, can I curse on here? I was like, fuck, [00:49:55] you don't because I've had symbols from the universe, if you will. And I've [00:50:00] had amazing magical things happen in my life. And I've also put myself kind of into a bit of a challenging temporary predicament, if you will, at times too. So what I would say that what do we do? I go back to my reason. [00:50:24] Why does that, does that make sense? [00:50:28] Izolda Trakhtenberg: [00:50:28] Absolutely. I mean, if that's your answer. Yes. [00:50:32] Jeanine Boubli: [00:50:32] Yeah, yeah. It's [00:50:33] Izolda Trakhtenberg: [00:50:33] I think that's a great answer. I think going back to basics, what, why am I doing what I'm doing? What is, what are the reasons I'm doing it? Yeah, that makes so much sense to me on some very deep levels, because I think that's sort of introspection when you face yourself. [00:50:49] With honesty and heart, you can't lie to yourself, you know, and we're really good at diluting ourselves. So as, as, as a [00:50:57] Jeanine Boubli: [00:50:57] species, yeah, I [00:50:58] Izolda Trakhtenberg: [00:50:58] could be good at that. [00:51:00] Yeah. Everybody can. I don't think there's anybody who has not lied to themselves every once in a while, but in your heart of hearts, you know, the truth. [00:51:06] So you can lie to yourself only so long before you have to pay the Piper and the Piper's you. So at some point you kind of go, well, I'm going to have to face this, whatever this is, and we all have a different path there to that, to that point. You know? So, so the question that I have, you, you mentioned ethic Al for a little bit ago, and I would love it. [00:51:27] If you would talk a little bit about that, because the, the photograph that we took together, I take a little screenshots so that people can see what's going to be on the show coming up. So it's going to go up a little bit later today. Yeah. It's so exciting. It's so I love, I love having those little pictures that say, look what is going to be on the show. [00:51:44] Yay. So talk to me and you're wearing an ethic Al. Shirt and I'd love it. If you could talk a little bit about what that is and, and what, what inspired you, what was the, what was the moment in the creative spark that got you there? [00:51:58] Jeanine Boubli: [00:51:58] Oh, sure, sure. So I [00:52:00] was sitting in this big chair that I've got and I you know, I've been frustrated or challenged with acceptance with that disconnect of ethical treatment of all animals being included in this, in quotes, sustainable conversation, why it's been either disconnected or overlooked? [00:52:19] I think like an oversight. I think it might be uncomfortable. People don't want to bring it up. They don't want to stir up whatever it is and yet. It's important for every reason for me animals first. So I was sitting on the chair and I, I happened to, I was just, you know, chilling a bit and I was like ethical, ethical, ethical, ethical ethics. [00:52:44] Oh, ah, I saw it. I saw it as old as I saw it. I saw design my eyes were closed and I saw it in my eye through my eyes. I saw this design ethic. Oh. So I went straight over [00:53:00] to my computer and open up illustrator and I typed up exactly what I saw with the bold font and the scripty part and the accent mark on the L and the last Ian, I know that's not the correct. [00:53:17] Accent mark in French. And I'm okay with that. It's artistic license. That's what I saw. That's what came to me. And it was so strong. It was like, look at me, see herself. When I knew there was something there I'm like, that's it that says everything with epic elk came to me. I was like, that's it? And it's something that I know just to be out there more. [00:53:38] And so it says the design ethic, L a strong and confident woman who is compassionate. Heart includes love. Wait, I'm sorry. Love and respect for all animals and mother nature [00:53:56] Izolda Trakhtenberg: [00:53:56] so much. I need that shirt. I'm again, I'm going to max out my [00:54:00] credit card. I think that's so that's right. That's at the heart of what I believe. [00:54:05] So you're speaking directly to my heart when you, when you read that, you know what I really want to honor for a second here. And I think it's so important to do this is that you listen to your inspirations that you went, oh, I see it. I know it. And you didn't go, ah, Nan, nevermind. Or, oh, it won't be any good or, oh, I'm going to discount it or, oh, I have to go wash the dishes you stopped and you went, let me put this down so that I have it so that I honor that creative spark when it comes. [00:54:37] And I'm wondering, do you have just do, is it just who you are that that happens or do you have any sort of. PR creative practice or any sort of, I'm going to build an awareness for this so that I can grab it when it comes. What, what is your [00:54:52] Jeanine Boubli: [00:54:52] process there? I would say that creativity like that comes when it wills, you know? [00:54:58]But I feel like it's like a [00:55:00] spiritual, spiritual connect. It's like a connection with something much greater than me. And I do have a spiritual practice. I've always been on spiritual in the sense that organized religion was never, never did it for me, but if I was out in nature, That did it for me or being creative that did it for me. [00:55:19]A universal truth that did it for me, something that was all inclusive. And so I, I, you know, I journal most mornings. I, I journal, I think you mentioned Julia camera and once that the artist's way. So I had many, many books and books and journals and things, and I remember even once moving from New Jersey back into Manhattan and having like all of these journals and my closet, and I said, oh, I looked at them and I said, oh, you know what? [00:55:48] You need to go because I've lived you and it's okay to release you. So as far as the spiritual practice, I've also recently, this is after all of these [00:56:00] creations, but I have very happily Notice more synchronicity in my life this past month I started meditating again. I love there's a insight timer or an app [00:56:11] Izolda Trakhtenberg: [00:56:11] that happens. [00:56:12] Jeanine Boubli: [00:56:12] I love it. Right. It's great. And they have, you know, you don't, you can pay for it or if there's a million meditations that are, you don't have to pay for. And it's great. There's a great variety. And yeah, so I really love that. So I've been doing that. So I meditate now. I, it doesn't have to be hours and hours and hours a bit in the morning before I get out of bed, I go ahead, make my tea. [00:56:36] I journal. And the evening before I go to sleep, just recently, like in the last week I started listening, listening to something. Before I go to sleep, I'm always like asleep before it's there. Yeah. And I also have to bet and singing bowls. Are they the best? [00:56:51] Izolda Trakhtenberg: [00:56:51] Yes. Yes. I had a whole set at one point. I love them. [00:56:55] Jeanine Boubli: [00:56:55] Wow. Yes. And the vibrations from the singing bowls is as if [00:57:00] the ocean is, it's like an ocean, like ocean, I, I feel like it's an ocean kind of a roar, but it, doesn't not, it's this bike back and forth and who like, sounds much better than that. And I can tell him, like I know, but sound like, but it's a very, very powerful, energetic vibe that yeah, that, that also that whenever, you know, I bring that into my life that also increased, it increases the creativity things that come to me visually word wise just feel connected and more at keys, if you will not scattered or. [00:57:41] The locks I feel open. Open. Yeah. [00:57:45] Izolda Trakhtenberg: [00:57:45] Yeah. I love, I love that notion of being, being mindful and letting the creativity flow from that space. I I've gotten increasingly [00:58:00] fascinated by the space between when an idea strikes and when you put words to it, you know, in that, in that instant, you can discount a completely or you can go, no, no, I'm going to stay open to this and see what happens. [00:58:12] And it sounds to me like you have, like, you have embraced that aspect of you and I have an entire framework that I talk about with my coaching clients, about how we can be agile, innovative, and mindful. And that is what leads to gratitude. And that is what leads to inspiration. And that is what leads to happiness and increased health, all sorts of things. [00:58:34] And so, so when you do that, when you're in that, and when you're in that head and heart space, Of creating. This is a strange little question. Do you lose time? [00:58:43] Jeanine Boubli: [00:58:43] Yes. There's no sense of, there is no sense of time at all. I mean, there's hours can go by. I mean, it can anything, there's only a few times, a few cases when that happens a lot to lose [00:59:00] sense of time. [00:59:00] It's being with the animals, it's being in a nature and it's when something creative bursts itself through us. Right. It's like it has a life of its own. And also everything's okay. It's everything is okay. It's not, oh, I've got to do this. Or, oh, shoot, how am I going to do that? Or it's like, it's, it's a knowing. [00:59:28] It's a deep knowing that no matter why everything's okay. Keep on going. It's not about what comes back from the outside. Just keep on going and trust. Because there is a journey that all of us, you know, we all have our own unique journeys. We might all feel love and happiness or sadness and all different things, but we do all have our own unique journey and it's up to us to honor. [00:59:56] What's deep inside of us, no matter [01:00:00] what everybody has something to share that. It's not only valuable to them, but that can actually also help others, [01:00:08] Izolda Trakhtenberg: [01:00:08] you know? Absolutely. And I feel like what you just said, really doves dovetails beautifully into, and there's an animal metaphor. I have to think of a different one now because because every time I noticed myself saying them, I go, Oh, that's another one you have to change. [01:00:23] So so the, the, the thing about that is that it does, it's it, it's going to coincide some with this notion of allowing yourself to. Be conscious about the contributions that you make. Right? So, so on some level, yes, we all have our own journey, but I think one of the signs of knowing yourself is also knowing, choosing how you will participate in, in this life. [01:00:56] Yes. So, so there there's something so powerful there to me [01:01:00] with what you just said about that, because, because it really does relate very well to being a conscious participant in your life rather than. Almost in a bystander or, or an observer. Hold on one second. Oh God, I'm gonna have to quiet myself down here. [01:01:19] Cause I'm coughing maniac here. [01:01:23] Jeanine Boubli: [01:01:23] Maybe get some water. [01:01:25] Izolda Trakhtenberg: [01:01:25] Oh, I'm drinking water. But sometimes when, I don't know if this happens to you, but sometimes when I get really passionate about what I'm saying, [01:01:34] so, and I'm very, very passionate about this subject. I think, I think the notion of living. It's weird to say cruelty-free because, because we, we don't, I don't think anybody wants to go or, or maybe, maybe there are some people who do, but I think a lot of us, most of us don't want to think of ourselves as being cruel. [01:01:53] And yet there, there are times that we have to face some pretty hard truths about who we are, and that's [01:02:00] not, again, it's not a judgment. It's more of a fact. Everybody has to face, like you said, we all have contribution we can make, and everybody has to face. Themselves and, and their, their beliefs and their behaviors. [01:02:12] And no one, no one else can do it for you on some level. So, so I'm so grateful that you have been here willing to share your story and your wisdom. And I'd love to ask, Oh, I love the bird in the background. That was great. Oh [01:02:30] yeah. I can hear it. That's beautiful. Oh, beautiful. I I'm a huge fan of bird calls, even though I don't, I don't know. I don't know how to differentiate too many of them, but I think they're beautiful. [01:02:41] Jeanine Boubli: [01:02:41] So happy that you're here and giving. This opportunity to me and to all your listeners. Oh, that's, [01:02:48] Izolda Trakhtenberg: [01:02:48] that's very sweet. [01:02:49] Thank you. My goodness. I love it. [01:02:54] Well, the birds going, I've got something to say here too. So sorry. So what's next for [01:03:00] you and for red tail moon, [01:03:02] Jeanine Boubli: [01:03:02] what's next for me is getting off my unit lot and reaching out to no, it's true. It's true. It's been like it, sometimes things sometimes it's easier to walk forward because there's something that, and sometimes it's uncomfortable not to walk forward and I'm at that place where it's uncomfortable not to go ahead and give it everything that it's got because it's every, it does mean everything to me. [01:03:29] So I'm planning on yes, I will do it. Go ahead and send some pitches out to different media and. See how I can collaborate with Stella. Are you there Stella McCartney? We're [01:03:45] Izolda Trakhtenberg: [01:03:45] calling [01:03:45] Jeanine Boubli: [01:03:45] you yes. Stella or somebody else like that. That might have the wisdom or things that know things that I don't know in maybe the retail industry to get [01:04:00] it to where it really does. [01:04:04] Izolda Trakhtenberg: [01:04:04] yeah. [01:04:05] Jeanine Boubli: [01:04:05] Went into collaborations and anybody, anybody listening to this as any comments or suggestions or conversation? What, well, you know, wants to know why does so and credibly special about it? Spending quiet time with sheep or not quiet time or anything. Yeah, I'm, I'm, I'm really open. I'm an open heart and but right [01:04:28] Izolda Trakhtenberg: [01:04:28] now, well, so, so they're, they're, they're, you're, you're, you're leading me beautifully down this particular path. [01:04:35] How can someone who is interested in finding out more about red tail moon find you? [01:04:40] Jeanine Boubli: [01:04:40] Oh, sure. So you can go to well, I'm on Instagram. I'm at red tail moon. So red Shalmar is spelled R E D T a L E M O O N T L like the moon. It is an honor of the red tail Hawk. But that's a whole nother story, but red tail moon [01:05:00] on Instagram red tail moon is also on Facebook. [01:05:03] I do not do a lot of things with Facebook, but I guess I probably, well and also red tailMoon@gmail.com. And my website, which is www.red tail T a L EMR. And then you get to see the different designs that we spoke about and you know, some pictures of the journey so far and clubhouse I'm at Janine bublé. [01:05:32] So that's at you know, the at symbol, Jenny, J E a N I N E B, like boy, O U B, like boy L I, and there are, there has been some interesting conversations, great conversations on clubhouse. So connect with me anyway. Any, any way anywhere I would love to hear from you. [01:05:50] Izolda Trakhtenberg: [01:05:50] And I'm going to have to find you in clubhouse too. [01:05:52] So because I don't want to connect connected on there yet. Yeah. And, and the thing about this, I'm going to put all of these on the show notes, but I find that it's also [01:06:00] really good if you say it because people learn different in different ways. So you'll be able to find these links on the show notes, and you'll be able to also, if you heard them and you want to write them down, find Janine, obviously she's doing amazing, incredible, inspiring, and gorgeous all at the same time, work on, on behalf of the animals. [01:06:19] And I I'm so thrilled that you were on the show. [01:06:24] Jeanine Boubli: [01:06:24] Thank you so much for having me. [01:06:26] Izolda Trakhtenberg: [01:06:26] It's my, my absolute honor and pleasure. I have one last question. And if you've listened to the episodes, you know what the question is? So I

On tonight’s program, we invite you to leave behind your safe reality, and descend with us into the frightening depths of the most terrifying imaginations, with an audio adaptation of a feature-length rendition of fearsome fiction from author Chris Koleszar, about rampaging receptacles.    Learn more about your ad choices. Visit megaphone.fm/adchoices

Host: Paul Paik, MD Guest: Jyoti D. Patel, MD, FASCO Lung cancer remains the most common cancer in the United States and Europe and second most common in Japan. Of patients with non-small cell lung cancer (NSCLC), approximately 3% to 4% have tumors that harbor MET gene aberrations including MET exon 14 skipping mutations. These patients have an even worse prognosis than others with NSCLC, and early diagnosis and targeted therapies are essential. Join us as Dr. Paul Paik and Dr. Jyoti Patel discuss the value that liquid biopsy brings to patients with NSCLC, specifically those with MET exon 14 skipping mutations.

CME credits: 0.25 Valid until: 23-04-2022 Claim your CME credit at https://reachmd.com/programs/cme/liquid-and-tissue-biopsy-treatment-nsclc-focus-met-gene-aberrations/12465/ Lung cancer remains the most common cancer in the United States and Europe and second most common in Japan. Of patients with non-small cell lung cancer (NSCLC), approximately 3% to 4% have tumors that harbor MET gene aberrations including MET exon 14 skipping mutations. These patients have an even worse prognosis than others with NSCLC, and early diagnosis and targeted therapies are essential. Join us as Dr. Paul Paik and Dr. Jyoti Patel discuss the value that liquid biopsy brings to patients with NSCLC, specifically those with MET exon 14 skipping mutations.

CME credits: 0.25 Valid until: 23-04-2022 Claim your CME credit at https://reachmd.com/programs/cme/liquid-and-tissue-biopsy-treatment-nsclc-focus-met-gene-aberrations/12465/ Lung cancer remains the most common cancer in the United States and Europe and second most common in Japan. Of patients with non-small cell lung cancer (NSCLC), approximately 3% to 4% have tumors that harbor MET gene aberrations including MET exon 14 skipping mutations. These patients have an even worse prognosis than others with NSCLC, and early diagnosis and targeted therapies are essential. Join us as Dr. Paul Paik and Dr. Jyoti Patel discuss the value that liquid biopsy brings to patients with NSCLC, specifically those with MET exon 14 skipping mutations.

Hello class, everyone get to your seats, we've got a lot to cover today. We are continuing our lecture series on the Keepers, and things are only going to ramp up from here. Where we last left off, Virgil and Jacques had overcome what felt like the universe itself throwing something that they were incredibly ill-equipped for directly at them in the form of two large, territorial bird Pokémon. Their unlikely victory was a strong reminder of the power of wits and the mind over sheer force, and an important confidence boost leading into the encounter to come. Now that our young Initiates are feeling better about their abilities and Pandora doesn't feel like she has to babysit them (as much as she did, anyway), our trio of Keepers are making their way into Amanita Town to begin tracking down the beasts threatening the dusty settlement. What do the people of Amanita Town know about the awful creatures? What has happened to the unfortunate souls who have encountered them already? And will Team Catapult get the information they need before the beasts come again? Let's find out in our latest installment… Amanita Aberrations! DM: Jonah M. Jackson / Virgil: Andrew Johnson / Jacques: Joseph Leitess Music: Braxton Burks & Materia Collective - The Adventure Begins, Trouble at Slowpoke Well, The Road to Fallarbor Town Mikel & Game Chops - Azalea Town Insaneintherainmusic - Spinda's Lament TrackTribe - Walk Through the Park RoccoW - Try A Music Coyote Hearing - Fun House Dark Fantasy Studio - Ashes TabletopAudio.com - Barren Wastes, Oregon Trail, Spire: New Heaven, Lonesome West, Ghost Town, Medieval Library, True West, Abandoned Windmill, Desert Winds

Dr. Karolinne Rocha discusses what surgeons need to know about optical aberrations as it relates to cataract surgery and IOL selection

Rickels returns to the Melanesian Cargo Cult, a mainstay of Aberrations of Mourning, to interpret the other term for what is at stake in Cargo: Savvy. While Cargo is carried by their ancestors, the Melanesians ascribe Savvy to the living. In the course of the Second World War, America replaces Europe and Australia on the Melanesian horizon. The Melanesians would have noted that Black Americans were in the US military. The Savvy ascribed to Americans (notably in the Johnson Movement) reflects the copresence of Blacks and amounts to a reading of American hipness as dependent on Black Savvy. The Trump Movement is the latest last hurrah of white Savvy, last seen in full array in Nazi Germany. That whiteness is by now a contact low is the estabishing shot of the denial that the Trump Movement symptomatizes.2020 Author Laurence Rickels Sound engineer Jochen Jezzusek In VOICEOVER, film material is recommended for watching while listening to the lecture. Blade (1998) should be muted while viewing. Hosted on Acast. See acast.com/privacy for more information.

In the conclusion of 'Aberrations' the crew faces the reality that there could be no limit to the danger posed by aberrant phenomena to friends and family... nor their own lives.© 2020 Eldritch StudiosCover photo for Part 6 courtesy of Kevin Parsons Photography ®

Eldritch Studios brings to you the spooky and mind-bending audio drama known as 'Aberrations,' a theatrical take on the novel 'Tryst: Based on Actual Events' by Aaron Eldritch. In Part 1, two brothers and their two friends experience something surreal and disturbing while enjoying a walk through the forest. Two years later the friends reminisce about the adventure, only to find that strange happenings have resurfaced.© 2020 Eldritch Studios

David Zipper set out to understand what areas of automated driving were most in need of regulation under the new Biden administration, and his research led him to a single answer: Tesla. Zipper joins the show to discuss why Tesla's approach to automated driving is so aberrant, why it should be regulated and how the Bident could rein it in. If you want to go deeper into Zipper's popular Slate piece on this topic, you'll want to listen to this episode.

The conversation with Grandma Elmtwinkle continues and some of the puzzle pieces begin to fall into place. Thorn, Clicker and Volun learn that they are dream walkers and that the fairy godmother Saffron and the Nightmare King are actually one ancient archfey from the autumn court named Sevosi; an archfey that became one of four living-locks to imprison the first fey, those called the Starlight Court! This insight is tempered as they meet a cantankerous dwarven barbarian named Bruce. Do you wanna know more? Embers from a Chimney II is a Crimson Nib podcast that will journey with 4 wayward adventurers into the heart of the Southlands; a land of mystery and adventure, where riches and dangers await those brave enough to cross the wild expanses. The campaign setting is Southlands from Kobold Press. We are using the D&D 5E ruleset, and we game using the Fantasy Grounds virtual tabletop. I am Dagobah and this is a Crimson Nib podcast, you can follow me here or on twitter @crimsonnib, or at facebook.com/crimsonnib. If you’ve enjoyed what you’ve heard, please rate and review me on google podcasts, itunes, or wherever you get your podcasts. VTT - Fantasy Grounds (http://www.fantasygrounds.com) Campaign Settings - Southlands (https://koboldpress.com/tag/southlands/) Find out more at https://crimsonnib.pinecast.co This podcast is powered by Pinecast.

On this episode we do a deep dive into the topic of Aberrations, exploring all of their teathy, tentacley weirdness. Dice Talk is part of the Majestic Goose podcast network Go to Dicetalkpod.com Go to MajesticGoose.com Go to Rollforweird.com Episode sponsored by: ShadowMarketPins.com  

Wrapping up our September line up, and easing into our Halloween themed episodes with none other than the Beholder, one of the most iconic monsters in D&D lore!  SOURCES: Greyhawk,, D&D Companion Rules set, The Dungeons & Dragons Rules Cyclopedia, All iterations of the Monster Manual,  "The Ecology of the Beholder" in Dragon #76, Spelljammer: AD&D Adventures in Space campaign set, the Lorebook of the Void booklet, I, Tyrant , Monstrous Compendium: Monsters of Faerun, Lords of Madness: The Book of Aberrations, Volo's Guide to Monsters, Xanathar's Guide to Everything, Waterdeep: Dragon Heist. Promo for "A Fool's Quest"  : https://afoolsquest.podiant.co/ Support the Podcast by shopping at our Teespring store!  https://teespring.com/stores/the-dungeon-masters-dojo You can also support the Dungeon Master's Dojo by heading over to Apple Podcasts and Podchaser leave a rating, and take the time to leave a comment as well. We want to know how we are doing and what topics you would like to hear about:   Apple Podcast and Podchaser link --- Send in a voice message: https://anchor.fm/thedungeonmastersdojo/message Support this podcast: https://anchor.fm/thedungeonmastersdojo/support

Illithids have haunted the minds of players and DMs alike since 1975 when they first appeared in Gary Gygax's Strategic Review newsletter. Since that time, they have appeared in every edition of D&D from OD&D to 5th edition. Sources: The Strategic Review #1, Eldritch Wizardry supplement, Dragon Magazine #78, Dragon Magazine #150, Monster Manuals AD&D through 5E, The Complete Psionics Handbook, Menzoberranzean boxed set, Dawn of the Overmind, & The Illithiad, Lords of Madness: Book of Aberrations. If you would like to hear a particular topic you can leave us a voice message on Anchor (we will include that in the podcast) or you can reach us on facebook at https://www.facebook.com/The-Dungeon-Masters-Dojo-103976808013364/ or just drop us an email at TheDungeonMastersDojo@Gmail.com. If you would like to “Support this podcast with a small monthly donation to help sustain future episodes." you can do so following the link on our Anchor home page" Thank you for your listening support. The DMD.. --- Send in a voice message: https://anchor.fm/thedungeonmastersdojo/message Support this podcast: https://anchor.fm/thedungeonmastersdojo/support

Welcome back to Wake Up, Anomaly Flats! Today, Squid and Mark welcome back the long-dead Anomaly Flats baseball team, the Aberrations! Plus, Squid proves himself to be a liability, and Mark attempts to set himself on fire! Colleen Branch's portal farm has been victimized, and there's something weird going on at the Roach Motel. The hosts introduce a new segment, Cooking With Carl, and then Dr. Lewis Burnish investigates the mysterious stones in the Lurchwood Forest for the Science Corner! *Wake Up, Anomaly Flats is sponsored by Mrs. Roach and the Roach Motel.

Ever wonder how to make the monsters of nightmares entertaining or how to integrate them more creatively into your world? Episode 2 of Dungeon Diving covers the strange and horrifying world of Aberrations including Beholders, Mind Flayers, and more! 

Includes a revisiting of The Predator after a year of learning more about the film’s production and a chance to watch the film again. Presented by Corporal Hicks, RidgeTop and Xenomorphine.

Twisted values will prevent you from experiencing financial health.

Bitterness will prevent you from experiencing relational health.

Guests: Nick Mamalis, MD Professor University of Utah Department of Ophthalmology and Visual Sciences Salt Lake City, UT Michael Greenwood, MD  Clinical Instructor of Surgery University of North Dakota School of Medicine and Health Sciences Fargo, N.D.

Camiya and Remi are seeing things, and S4M is becoming increasingly frustrated at his meat bags not working properly.   No Match For A Blaster is a podcast by Morality Plays.If you have a comment for the show, find us on Facebook or Twitter, @NoMatchPodcast. Star Wars: Edge of the Empire, Age of Rebellion, and Force and Destiny are made by Fantasy Flight Games and Lucas Books. Our theme is by Kevin MacLeod, sound effects by Tristan Lohengrin, vedas, and akemov.

“The Mourner’s March is about as close to living inside the Miasma as one could experience without wandering inside it outright. Aberrations of all sorts practically run that length of swampland thickets and mossy oaks, and they tend to vex them what venture through the March almost as bad as they do the folks in Lockstock up yon the border.Some fella out Boon way told me, and you’re gonna be particularly interested in this my friend, he told me there’s an old campus out there in the March. A regular bastion of higher learning out there in the Miasma, and ain’t nobody been out there since afore the Encursion.I’m not saying it’s gonna be just a trifle to walk up in there and take your pick of the litter, but if ever there were an untapped well of knowledge, I’d say it was there. Right there in the Library at Abernathy College.”*In today’s episode, we join our party of intrepid Wanderers as they brave the Miasma in search of relics from a bygone time, and find much more than they bargained for waiting for them. The crew also discuss the basics of adventuring in Dungeon World. Swampy wastelands, old enemies, and polytheistic dog priests abound.This week on Play By Podcast: The Interdependency Shuffle 02: The Library at Abernathy CollegePlay By Podcast is Michael Collins (@arealwriter), Leon Barnes (@SlapKatZ), Liam Higgins(@KeepCalmKlingon), and Laura Coe (@_NotMyDivision_)Cover Art by Ariel Corrales (@arielcorrales_)Music by Cody Ojea (@SixChordCircus)

Marcus Marcus reflects on the people of the Northern Marches and the Aberrations that once lived there. Subscribe now to enjoy the weekly episodes. Written and performed by Rab S. Fulton. Music by Rab S. FultonRead this chapter in An Áit Eile Ireland's best online creativity zine: http://www.aae.ie/marcus-marcus-hurting-heart-rab-s-fulton-4/ Illustration by Marina Wild. Check out: www.marinawild.com For more about Rab’s work as author, storyteller & podcaster checkout: http://rabfultonstories.weebly.com Follow Rab at: Facebook: facebook.com/celtictalesrabfulton Twitter: @haveringrab Instagram @Celtictalesgalway Email: celtictales@gmail.com Listen to Rab's live shows on https://www.mixcloud.com/rabfulton/

Les soupers spaghetti des politiciens et les aberrations de notre province de cul by NexRadio.ca

Episode 10 is all about Southern African armoured lizards of the family Cordylidae. Some live in groups - why? Why are they so damn spikey? These and other mysteries at least partially revealed. Plus, a brand new species of cordylid lizard from Angola and an aside about the tokay gecko trade. FULL REFERENCE LIST AVAILABLE AT: herphighlights.podbean.com   Main Paper References: Broeckhoven, Chris, Genevieve Diedericks, Cang Hui, Buyisile G. Makhubo, and P. le Fras N. Mouton. 2016. “Enemy at the Gates: Rapid Defensive Trait Diversification in an Adaptive Radiation of Lizards.” Evolution 70 (11): 2647–56. Broeckhoven, Chris, and Pieter Le Fras Nortier Mouton. 2015. “Some like It Hot: Camera Traps Unravel the Effects of Weather Conditions and Predator Presence on the Activity Levels of Two Lizards.” PLoS ONE 10 (9): 1–15. OPEN ACCESS Mouton, P le Fras N, Janine L Glover, and Alexander F Flemming. 2014. “Solitary Individuals in Populations of the Group-Living Lizard Ouroborus Cataphractus: Voluntary or Forced?” African Zoology 49 (2): 307–10. Species of the Bi-Week: Stanley, Edward L., Luis MP Ceriaco, Suzana Bandeira, Hilaria Valerio, Michael F. Bates, and William R. Branch. 2016. "A review of Cordylus machadoi (Squamata: Cordylidae) in southwestern Angola, with the description of a new species from the Pro-Namib desert." Zootaxa 4061(3): 201-226. Other Mentioned Papers/Studies: Ariefiandy, Achmad, Deni Purwandana, Aganto Seno, Claudio Ciofi, and Tim S. Jessop. 2013. “Can Camera Traps Monitor Komodo Dragons a Large Ectothermic Predator?” PLoS ONE 8 (3): 1–8. OPEN ACCESS Brodie III, E.D., and E.D. Brodie Jr. 1999. “Costs of Exploiting Poisonous Prey: Evolutionary Trade-Offs in a Predator-Prey Arms Race.” Evolution 2 (53): 626–31. OPEN ACCESS Buchanan, S. W., Timm, B. C., Cook, R. P., Couse, R., & Hazard, L. C. (2016). Surface Activity and Body Temperature of Eastern Hognose Snakes (Heterodon platirhinos) at Cape Cod National Seashore, Massachusetts USA. Journal of Herpetology. Ivany, L C, W P Patterson, and K C Lohmann. 2000. “Cooler Winters as a Possible Cause of Mass Extinctions at the Eocene/Oligocene Boundary.” Nature 407 (6806): 887–90. Lima, S. L. (1995). Back to the basics of anti-predatory vigilance: the group-size effect. Animal Behaviour, 49(1), 11-20. Losos, Jonathan B., P.Le Fras N. Mouton, Ryan Bickel, Ian Cornelius, and Lanral Ruddock. 2002. “The Effect of Body Armature on Escape Behaviour in Cordylid Lizards.” Animal Behaviour 64 (2): 313–21. Mouton, P., Flemming, A. F., & Kanga, E. M. (1999). Grouping behaviour, tail-biting behaviour and sexual dimorphism in the armadillo lizard (Cordylus cataphractus) from South Africa. Journal of Zoology, 249(1), 1-10. Nijman, Vincent, and Chris R Shepherd. 2015. “TRAFFIC Report: Adding up the Numbers : An Investigation into Commercial Breeding of Tokay Gecko in Indonesia.” Petaling Jaya, Selangor, Malaysia. OPEN ACCESS Stanley, Edward L.; Aaron M. Bauer; Todd R. Jackman, William R. Branch, P. Le Fras N. Mouton 2011. Between a rock and a hard polytomy: rapid radiation in the rupicolous girdled lizard (Squamata: Cordylidae). Molecular Phylogenetics and Evolution, 58(1): 53-70. Truter, Johannes Christoff, Johannes Hendrik VanWyk, and Pieter le Fras Nortier Mouton. 2014. “An Evaluation of Daily, Seasonal and Population-Level Variation in the Thermal Preference of a Group-Living Lizard, Ouroborus Cataphractus (Sauria: Cordylidae).” Amphibia-Reptilia 35 (4): 391–403. Zachos, J., Mark Pagani, Lisa Sloan, Ellen Thomas, and Katharina Billups. 2001. “Trends, Rhythms, and Aberrations in Global Climate 65 Ma to Present.” Science 292 (5517): 686–93. Other links and mentions: iHerp magazine - https://iherpaustralia.com.au/ Music – Treehouse by Ed Nelson

Karolinne Rocha, MD, PhD, recounts her ophthalmology journey to Gary Wörtz, MD, and shares her experience training in Brazil and then retraining in the United States. Listen in as Dr. Rocha discusses her insights into spherical aberrations, premium lenses, and the importance of efficiency in being a successful practitioner, partner, and parent.

Karolinne Rocha, MD, PhD, recounts her ophthalmology journey to Gary Wörtz, MD, and shares her experience training in Brazil and then retraining in the United States. Listen in as Dr. Rocha discusses her insights into spherical aberrations, premium lenses, and the importance of efficiency in being a successful practitioner, partner, and parent.

The Psycho Records (Wallflower Press) Skylight Books and Villa Aurora are proud to present Laurence A. Rickels, reading from his newest book The Psycho Records. The Psycho Records follows the influence of the primal shower scene within subsequent slasher and splatter films. American soldiers returning from World War II were called “psychos” if they exhibited mental illness. Robert Bloch and Alfred Hitchcock turned the term into a catch-all phrase for a range of psychotic and psychopathic symptoms or dispositions. They transferred a war disorder to the American heartland. Drawing on his experience with German film, Hitchcock packed inside his shower stall the essence of schauer, the German cognate meaning “horror.” Later serial horror film production has post-traumatically flashed back to Hitchcock’s shower scene. In the end, though, this book argues the effect is therapeutically finite. This extensive case study summons the genealogical readings of philosopher and psychoanalyst Laurence Rickels. The book opens not with another reading of Hitchcock’s 1960 film but with an evaluation of various updates to vampirism over the years. It concludes with a close look at the rise of demonic and infernal tendencies in horror movies since the 1990s and the problem of the psycho as our most uncanny double in close quarters. Laurence A. Rickels is professor in art and theory at the Academy of Fine Arts Karlsruhe. He is the author of Aberrations of Mourning (1988), The Case of California (2001), Nazi Psychoanalysis (2002), The Vampire Lectures (1999), The Devil Notebooks (2008), Ulrike Ottinger: The Autobiography of Art Cinema (2008), I Think I Am: Philip K. Dick (2010), and Germany: A Science Fiction (2015).

In this episode, James Anthony is back in NY and returns as a guest on WGB. We're back live from the Adorama Event Space and talking about how your lifestyle can enhance your work ethic, new ventures, plans for LA, and sliding in celebrity DMs. www.JamesAnthonyPhotos.com Instagram.com/IamJamesAnthony www.BryonSummers.com Instagram.com/BryonSummers Phocabulary: Aberration A distortion of image quality or color rendition in a photographic image caused by optical limitations of the lens used to capture the image. Aberrations commonly show up in the form of halation around contrasty portions of the image or “smearing” of color toward the edges of the frame. Aspheric lens surfaces and advanced lens coatings are often used in more expensive or complex lenses as a means of reducing aberrations. Source: http://www.bhphotovideo.com/explora/photography/buying-guide/glossary-digital-photography-terms Book The War of Art Steven Pressfield The hardest thing for some of us to do is start. The War of Art talks about how to avoid creative roadblocks whether you're a writer, painter, or photographer. Pressfield identifies the enemy we must face, outlines a plan to battle it, and pinpoints how to achieve success. I've been hearing a lot about this book. Actually thumbed through it at Barnes & Noble recently. Guess I'll be going back to pick up. Music: KB @push-music --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/bryonsummers/support

Could you believe that even the great fairytale of Rapunzel carries keys of cosmological wisdom? In this sixth episode of the Starry Telling Podcast, More Than Astrologer Gemini Brett forays into the fairy forest to open windows into the current story of Sacred Marriage as expressed by the dance of Venus and Mars. Six is the number of the Lovers in the tarot, after all. This StarryTelling was fueled by the high magic of singer / songwriter Water Dropz who gifted the episode with live accompaniment and the incredible improvised composition "I Will Bring You Roses." Episode Six closes with Water's "Mana Prima" from her album "Dream Me Open," a collaboration with visionary artist Eric Nez, whose painting from the project you see here. Follow the links below to find more of Water Dropz, Eric Nez, Gemini Brett, and much more about the cycles of Venus and Mars. Thank you for tuning in! See you in Starry Story Space! Love and Planets, Gemini Brett www.MoreThanAstrology.com www.WaterDropz.bandcamp.com www.EricNez.com www.OneDoorLand.com Rapunzel Cosmology by William Irwin Thompson: http://uh494.yolasite.com/resources/KIC%20Document%200001.pdf "Mercury, Venus and Mars" from Daniel Giamario, visionary of the Shamanic Astrology paradigm: http://shamanicastrology.com/archives/category/articles/venus-mars-and-mercury-articles "Aberrations in the Venus Mars Cycle" - Robert Blaschke - Mountain Astrologer Magazine - 2010: http://mountainastrologer.com/tma/aberrations-in-the-venus-mars-cycle We'll be diving deeper into these Venus and Mars episodes through interviews with Gary Caton (dreamastrologer.com) and Daniel Giamario (shamanicastrology.com) in the very near future.

The Foundations of Religious Faith (1118.1) 102:0.1 TO THE unbelieving materialist, man is simply an evolutionary accident. His hopes of survival are strung on a figment of mortal imagination; his fears, loves, longings, and beliefs are but the reaction of the incidental juxtaposition of certain lifeless atoms of matter. No display of energy nor expression of trust can carry him beyond the grave. The devotional labors and inspirational genius of the best of men are doomed to be extinguished by death, the long and lonely night of eternal oblivion and soul extinction. Nameless despair is man’s only reward for living and toiling under the temporal sun of mortal existence. Each day of life slowly and surely tightens the grasp of a pitiless doom which a hostile and relentless universe of matter has decreed shall be the crowning insult to everything in human desire which is beautiful, noble, lofty, and good. (1118.2) 102:0.2 But such is not man’s end and eternal destiny; such a vision is but the cry of despair uttered by some wandering soul who has become lost in spiritual darkness, and who bravely struggles on in the face of the mechanistic sophistries of a material philosophy, blinded by the confusion and distortion of a complex learning. And all this doom of darkness and all this destiny of despair are forever dispelled by one brave stretch of faith on the part of the most humble and unlearned of God’s children on earth. (1118.3) 102:0.3 This saving faith has its birth in the human heart when the moral consciousness of man realizes that human values may be translated in mortal experience from the material to the spiritual, from the human to the divine, from time to eternity. 1. Assurances of Faith (1118.4) 102:1.1 The work of the Thought Adjuster constitutes the explanation of the translation of man’s primitive and evolutionary sense of duty into that higher and more certain faith in the eternal realities of revelation. There must be perfection hunger in man’s heart to insure capacity for comprehending the faith paths to supreme attainment. If any man chooses to do the divine will, he shall know the way of truth. It is literally true, “Human things must be known in order to be loved, but divine things must be loved in order to be known.” But honest doubts and sincere questionings are not sin; such attitudes merely spell delay in the progressive journey toward perfection attainment. Childlike trust secures man’s entrance into the kingdom of heavenly ascent, but progress is wholly dependent on the vigorous exercise of the robust and confident faith of the full-grown man. (1119.1) 102:1.2 The reason of science is based on the observable facts of time; the faith of religion argues from the spirit program of eternity. What knowledge and reason cannot do for us, true wisdom admonishes us to allow faith to accomplish through religious insight and spiritual transformation. (1119.2) 102:1.3 Owing to the isolation of rebellion, the revelation of truth on Urantia has all too often been mixed up with the statements of partial and transient cosmologies. Truth remains unchanged from generation to generation, but the associated teachings about the physical world vary from day to day and from year to year. Eternal truth should not be slighted because it chances to be found in company with obsolete ideas regarding the material world. The more of science you know, the less sure you can be; the more of religion you have, the more certain you are. (1119.3) 102:1.4 The certainties of science proceed entirely from the intellect; the certitudes of religion spring from the very foundations of the entire personality. Science appeals to the understanding of the mind; religion appeals to the loyalty and devotion of the body, mind, and spirit, even to the whole personality. (1119.4) 102:1.5 God is so all real and absolute that no material sign of proof or no demonstration of so-called miracle may be offered in testimony of his reality. Always will we know him because we trust him, and our belief in him is wholly based on our personal participation in the divine manifestations of his infinite reality. (1119.5) 102:1.6 The indwelling Thought Adjuster unfailingly arouses in man’s soul a true and searching hunger for perfection together with a far-reaching curiosity which can be adequately satisfied only by communion with God, the divine source of that Adjuster. The hungry soul of man refuses to be satisfied with anything less than the personal realization of the living God. Whatever more God may be than a high and perfect moral personality, he cannot, in our hungry and finite concept, be anything less. 2. Religion and Reality (1119.6) 102:2.1 Observing minds and discriminating souls know religion when they find it in the lives of their fellows. Religion requires no definition; we all know its social, intellectual, moral, and spiritual fruits. And this all grows out of the fact that religion is the property of the human race; it is not a child of culture. True, one’s perception of religion is still human and therefore subject to the bondage of ignorance, the slavery of superstition, the deceptions of sophistication, and the delusions of false philosophy. (1119.7) 102:2.2 One of the characteristic peculiarities of genuine religious assurance is that, notwithstanding the absoluteness of its affirmations and the stanchness of its attitude, the spirit of its expression is so poised and tempered that it never conveys the slightest impression of self-assertion or egoistic exaltation. The wisdom of religious experience is something of a paradox in that it is both humanly original and Adjuster derivative. Religious force is not the product of the individual’s personal prerogatives but rather the outworking of that sublime partnership of man and the everlasting source of all wisdom. Thus do the words and acts of true and undefiled religion become compellingly authoritative for all enlightened mortals. (1119.8) 102:2.3 It is difficult to identify and analyze the factors of a religious experience, but it is not difficult to observe that such religious practitioners live and carry on as if already in the presence of the Eternal. Believers react to this temporal life as if immortality already were within their grasp. In the lives of such mortals there is a valid originality and a spontaneity of expression that forever segregate them from those of their fellows who have imbibed only the wisdom of the world. Religionists seem to live in effective emancipation from harrying haste and the painful stress of the vicissitudes inherent in the temporal currents of time; they exhibit a stabilization of personality and a tranquillity of character not explained by the laws of physiology, psychology, and sociology. (1120.1) 102:2.4 Time is an invariable element in the attainment of knowledge; religion makes its endowments immediately available, albeit there is the important factor of growth in grace, definite advancement in all phases of religious experience. Knowledge is an eternal quest; always are you learning, but never are you able to arrive at the full knowledge of absolute truth. In knowledge alone there can never be absolute certainty, only increasing probability of approximation; but the religious soul of spiritual illumination knows, and knows now. And yet this profound and positive certitude does not lead such a sound-minded religionist to take any less interest in the ups and downs of the progress of human wisdom, which is bound up on its material end with the developments of slow-moving science. (1120.2) 102:2.5 Even the discoveries of science are not truly real in the consciousness of human experience until they are unraveled and correlated, until their relevant facts actually become meaning through encircuitment in the thought streams of mind. Mortal man views even his physical environment from the mind level, from the perspective of its psychological registry. It is not, therefore, strange that man should place a highly unified interpretation upon the universe and then seek to identify this energy unity of his science with the spirit unity of his religious experience. Mind is unity; mortal consciousness lives on the mind level and perceives the universal realities through the eyes of the mind endowment. The mind perspective will not yield the existential unity of the source of reality, the First Source and Center, but it can and sometime will portray to man the experiential synthesis of energy, mind, and spirit in and as the Supreme Being. But mind can never succeed in this unification of the diversity of reality unless such mind is firmly aware of material things, intellectual meanings, and spiritual values; only in the harmony of the triunity of functional reality is there unity, and only in unity is there the personality satisfaction of the realization of cosmic constancy and consistency. (1120.3) 102:2.6 Unity is best found in human experience through philosophy. And while the body of philosophic thought must ever be founded on material facts, the soul and energy of true philosophic dynamics is mortal spiritual insight. (1120.4) 102:2.7 Evolutionary man does not naturally relish hard work. To keep pace in his life experience with the impelling demands and the compelling urges of a growing religious experience means incessant activity in spiritual growth, intellectual expansion, factual enlargement, and social service. There is no real religion apart from a highly active personality. Therefore do the more indolent of men often seek to escape the rigors of truly religious activities by a species of ingenious self-deception through resorting to a retreat to the false shelter of stereotyped religious doctrines and dogmas. But true religion is alive. Intellectual crystallization of religious concepts is the equivalent of spiritual death. You cannot conceive of religion without ideas, but when religion once becomes reduced only to an idea, it is no longer religion; it has become merely a species of human philosophy. (1121.1) 102:2.8 Again, there are other types of unstable and poorly disciplined souls who would use the sentimental ideas of religion as an avenue of escape from the irritating demands of living. When certain vacillating and timid mortals attempt to escape from the incessant pressure of evolutionary life, religion, as they conceive it, seems to present the nearest refuge, the best avenue of escape. But it is the mission of religion to prepare man for bravely, even heroically, facing the vicissitudes of life. Religion is evolutionary man’s supreme endowment, the one thing which enables him to carry on and “endure as seeing Him who is invisible.” Mysticism, however, is often something of a retreat from life which is embraced by those humans who do not relish the more robust activities of living a religious life in the open arenas of human society and commerce. True religion must act. Conduct will be the result of religion when man actually has it, or rather when religion is permitted truly to possess the man. Never will religion be content with mere thinking or unacting feeling. (1121.2) 102:2.9 We are not blind to the fact that religion often acts unwisely, even irreligiously, but it acts. Aberrations of religious conviction have led to bloody persecutions, but always and ever religion does something; it is dynamic! 3. Knowledge, Wisdom, and Insight (1121.3) 102:3.1 Intellectual deficiency or educational poverty unavoidably handicaps higher religious attainment because such an impoverished environment of the spiritual nature robs religion of its chief channel of philosophic contact with the world of scientific knowledge. The intellectual factors of religion are important, but their overdevelopment is likewise sometimes very handicapping and embarrassing. Religion must continually labor under a paradoxical necessity: the necessity of making effective use of thought while at the same time discounting the spiritual serviceableness of all thinking. (1121.4) 102:3.2 Religious speculation is inevitable but always detrimental; speculation invariably falsifies its object. Speculation tends to translate religion into something material or humanistic, and thus, while directly interfering with the clarity of logical thought, it indirectly causes religion to appear as a function of the temporal world, the very world with which it should everlastingly stand in contrast. Therefore will religion always be characterized by paradoxes, the paradoxes resulting from the absence of the experiential connection between the material and the spiritual levels of the universe — morontia mota, the superphilosophic sensitivity for truth discernment and unity perception. (1121.5) 102:3.3 Material feelings, human emotions, lead directly to material actions, selfish acts. Religious insights, spiritual motivations, lead directly to religious actions, unselfish acts of social service and altruistic benevolence. (1121.6) 102:3.4 Religious desire is the hunger quest for divine reality. Religious experience is the realization of the consciousness of having found God. And when a human being does find God, there is experienced within the soul of that being such an indescribable restlessness of triumph in discovery that he is impelled to seek loving service-contact with his less illuminated fellows, not to disclose that he has found God, but rather to allow the overflow of the welling-up of eternal goodness within his own soul to refresh and ennoble his fellows. Real religion leads to increased social service. (1122.1) 102:3.5 Science, knowledge, leads to fact consciousness; religion, experience, leads to value consciousness; philosophy, wisdom, leads to co-ordinate consciousness; revelation (the substitute for morontia mota) leads to the consciousness of true reality; while the co-ordination of the consciousness of fact, value, and true reality constitutes awareness of personality reality, maximum of being, together with the belief in the possibility of the survival of that very personality.* (1122.2) 102:3.6 Knowledge leads to placing men, to originating social strata and castes. Religion leads to serving men, thus creating ethics and altruism. Wisdom leads to the higher and better fellowship of both ideas and one’s fellows. Revelation liberates men and starts them out on the eternal adventure. (1122.3) 102:3.7 Science sorts men; religion loves men, even as yourself; wisdom does justice to differing men; but revelation glorifies man and discloses his capacity for partnership with God. (1122.4) 102:3.8 Science vainly strives to create the brotherhood of culture; religion brings into being the brotherhood of the spirit. Philosophy strives for the brotherhood of wisdom; revelation portrays the eternal brotherhood, the Paradise Corps of the Finality. (1122.5) 102:3.9 Knowledge yields pride in the fact of personality; wisdom is the consciousness of the meaning of personality; religion is the experience of cognizance of the value of personality; revelation is the assurance of personality survival. (1122.6) 102:3.10 Science seeks to identify, analyze, and classify the segmented parts of the limitless cosmos. Religion grasps the idea-of-the-whole, the entire cosmos. Philosophy attempts the identification of the material segments of science with the spiritual-insight concept of the whole. Wherein philosophy fails in this attempt, revelation succeeds, affirming that the cosmic circle is universal, eternal, absolute, and infinite. This cosmos of the Infinite I AM is therefore endless, limitless, and all-inclusive — timeless, spaceless, and unqualified. And we bear testimony that the Infinite I AM is also the Father of Michael of Nebadon and the God of human salvation. (1122.7) 102:3.11 Science indicates Deity as a fact; philosophy presents the idea of an Absolute; religion envisions God as a loving spiritual personality. Revelation affirms the unity of the fact of Deity, the idea of the Absolute, and the spiritual personality of God and, further, presents this concept as our Father — the universal fact of existence, the eternal idea of mind, and the infinite spirit of life.* (1122.8) 102:3.12 The pursuit of knowledge constitutes science; the search for wisdom is philosophy; the love for God is religion; the hunger for truth is a revelation. But it is the indwelling Thought Adjuster that attaches the feeling of reality to man’s spiritual insight into the cosmos. (1122.9) 102:3.13 In science, the idea precedes the expression of its realization; in religion, the experience of realization precedes the expression of the idea. There is a vast difference between the evolutionary will-to-believe and the product of enlightened reason, religious insight, and revelation — the will that believes. (1122.10) 102:3.14 In evolution, religion often leads to man’s creating his concepts of God; revelation exhibits the phenomenon of God’s evolving man himself, while in the earth life of Christ Michael we behold the phenomenon of God’s revealing himself to man. Evolution tends to make God manlike; revelation tends to make man Godlike. (1122.11) 102:3.15 Science is only satisfied with first causes, religion with supreme personality, and philosophy with unity. Revelation affirms that these three are one, and that all are good. The eternal real is the good of the universe and not the time illusions of space evil. In the spiritual experience of all personalities, always is it true that the real is the good and the good is the real. 4. The Fact of Experience (1123.1) 102:4.1 Because of the presence in your minds of the Thought Adjuster, it is no more of a mystery for you to know the mind of God than for you to be sure of the consciousness of knowing any other mind, human or superhuman. Religion and social consciousness have this in common: They are predicated on the consciousness of other-mindness. The technique whereby you can accept another’s idea as yours is the same whereby you may “let the mind which was in Christ be also in you.” (1123.2) 102:4.2 What is human experience? It is simply any interplay between an active and questioning self and any other active and external reality. The mass of experience is determined by depth of concept plus totality of recognition of the reality of the external. The motion of experience equals the force of expectant imagination plus the keenness of the sensory discovery of the external qualities of contacted reality. The fact of experience is found in self-consciousness plus other-existences — other-thingness, other-mindness, and other-spiritness. (1123.3) 102:4.3 Man very early becomes conscious that he is not alone in the world or the universe. There develops a natural spontaneous self-consciousness of other-mindness in the environment of selfhood. Faith translates this natural experience into religion, the recognition of God as the reality — source, nature, and destiny — of other-mindness. But such a knowledge of God is ever and always a reality of personal experience. If God were not a personality, he could not become a living part of the real religious experience of a human personality. (1123.4) 102:4.4 The element of error present in human religious experience is directly proportional to the content of materialism which contaminates the spiritual concept of the Universal Father. Man’s prespirit progression in the universe consists in the experience of divesting himself of these erroneous ideas of the nature of God and of the reality of pure and true spirit. Deity is more than spirit, but the spiritual approach is the only one possible to ascending man. (1123.5) 102:4.5 Prayer is indeed a part of religious experience, but it has been wrongly emphasized by modern religions, much to the neglect of the more essential communion of worship. The reflective powers of the mind are deepened and broadened by worship. Prayer may enrich the life, but worship illuminates destiny. (1123.6) 102:4.6 Revealed religion is the unifying element of human existence. Revelation unifies history, co-ordinates geology, astronomy, physics, chemistry, biology, sociology, and psychology. Spiritual experience is the real soul of man’s cosmos. 5. The Supremacy of Purposive Potential (1123.7) 102:5.1 Although the establishment of the fact of belief is not equivalent to establishing the fact of that which is believed, nevertheless, the evolutionary progression of simple life to the status of personality does demonstrate the fact of the existence of the potential of personality to start with. And in the time universes, potential is always supreme over the actual. In the evolving cosmos the potential is what is to be, and what is to be is the unfolding of the purposive mandates of Deity. (1124.1) 102:5.2 This same purposive supremacy is shown in the evolution of mind ideation when primitive animal fear is transmuted into the constantly deepening reverence for God and into increasing awe of the universe. Primitive man had more religious fear than faith, and the supremacy of spirit potentials over mind actuals is demonstrated when this craven fear is translated into living faith in spiritual realities. (1124.2) 102:5.3 You can psychologize evolutionary religion but not the personal-experience religion of spiritual origin. Human morality may recognize values, but only religion can conserve, exalt, and spiritualize such values. But notwithstanding such actions, religion is something more than emotionalized morality. Religion is to morality as love is to duty, as sonship is to servitude, as essence is to substance. Morality discloses an almighty Controller, a Deity to be served; religion discloses an all-loving Father, a God to be worshiped and loved. And again this is because the spiritual potentiality of religion is dominant over the duty actuality of the morality of evolution. 6. The Certainty of Religious Faith (1124.3) 102:6.1 The philosophic elimination of religious fear and the steady progress of science add greatly to the mortality of false gods; and even though these casualties of man-made deities may momentarily befog the spiritual vision, they eventually destroy that ignorance and superstition which so long obscured the living God of eternal love. The relation between the creature and the Creator is a living experience, a dynamic religious faith, which is not subject to precise definition. To isolate part of life and call it religion is to disintegrate life and to distort religion. And this is just why the God of worship claims all allegiance or none. (1124.4) 102:6.2 The gods of primitive men may have been no more than shadows of themselves; the living God is the divine light whose interruptions constitute the creation shadows of all space. (1124.5) 102:6.3 The religionist of philosophic attainment has faith in a personal God of personal salvation, something more than a reality, a value, a level of achievement, an exalted process, a transmutation, the ultimate of time-space, an idealization, the personalization of energy, the entity of gravity, a human projection, the idealization of self, nature’s upthrust, the inclination to goodness, the forward impulse of evolution, or a sublime hypothesis. The religionist has faith in a God of love. Love is the essence of religion and the wellspring of superior civilization. (1124.6) 102:6.4 Faith transforms the philosophic God of probability into the saving God of certainty in the personal religious experience. Skepticism may challenge the theories of theology, but confidence in the dependability of personal experience affirms the truth of that belief which has grown into faith. (1124.7) 102:6.5 Convictions about God may be arrived at through wise reasoning, but the individual becomes God-knowing only by faith, through personal experience. In much that pertains to life, probability must be reckoned with, but when contacting with cosmic reality, certainty may be experienced when such meanings and values are approached by living faith. The God-knowing soul dares to say, “I know,” even when this knowledge of God is questioned by the unbeliever who denies such certitude because it is not wholly supported by intellectual logic. To every such doubter the believer only replies, “How do you know that I do not know?” (1125.1) 102:6.6 Though reason can always question faith, faith can always supplement both reason and logic. Reason creates the probability which faith can transform into a moral certainty, even a spiritual experience. God is the first truth and the last fact; therefore does all truth take origin in him, while all facts exist relative to him. God is absolute truth. As truth one may know God, but to understand — to explain — God, one must explore the fact of the universe of universes. The vast gulf between the experience of the truth of God and ignorance as to the fact of God can be bridged only by living faith. Reason alone cannot achieve harmony between infinite truth and universal fact. (1125.2) 102:6.7 Belief may not be able to resist doubt and withstand fear, but faith is always triumphant over doubting, for faith is both positive and living. The positive always has the advantage over the negative, truth over error, experience over theory, spiritual realities over the isolated facts of time and space. The convincing evidence of this spiritual certainty consists in the social fruits of the spirit which such believers, faithers, yield as a result of this genuine spiritual experience. Said Jesus: “If you love your fellows as I have loved you, then shall all men know that you are my disciples.” (1125.3) 102:6.8 To science God is a possibility, to psychology a desirability, to philosophy a probability, to religion a certainty, an actuality of religious experience. Reason demands that a philosophy which cannot find the God of probability should be very respectful of that religious faith which can and does find the God of certitude. Neither should science discount religious experience on grounds of credulity, not so long as it persists in the assumption that man’s intellectual and philosophic endowments emerged from increasingly lesser intelligences the further back they go, finally taking origin in primitive life which was utterly devoid of all thinking and feeling. (1125.4) 102:6.9 The facts of evolution must not be arrayed against the truth of the reality of the certainty of the spiritual experience of the religious living of the God-knowing mortal. Intelligent men should cease to reason like children and should attempt to use the consistent logic of adulthood, logic which tolerates the concept of truth alongside the observation of fact. Scientific materialism has gone bankrupt when it persists, in the face of each recurring universe phenomenon, in refunding its current objections by referring what is admittedly higher back into that which is admittedly lower. Consistency demands the recognition of the activities of a purposive Creator. (1125.5) 102:6.10 Organic evolution is a fact; purposive or progressive evolution is a truth which makes consistent the otherwise contradictory phenomena of the ever-ascending achievements of evolution. The higher any scientist progresses in his chosen science, the more will he abandon the theories of materialistic fact in favor of the cosmic truth of the dominance of the Supreme Mind. Materialism cheapens human life; the gospel of Jesus tremendously enhances and supernally exalts every mortal. Mortal existence must be visualized as consisting in the intriguing and fascinating experience of the realization of the reality of the meeting of the human upreach and the divine and saving downreach. 7. The Certitude of the Divine (1126.1) 102:7.1 The Universal Father, being self-existent, is also self-explanatory; he actually lives in every rational mortal. But you cannot be sure about God unless you know him; sonship is the only experience which makes fatherhood certain. The universe is everywhere undergoing change. A changing universe is a dependent universe; such a creation cannot be either final or absolute. A finite universe is wholly dependent on the Ultimate and the Absolute. The universe and God are not identical; one is cause, the other effect. The cause is absolute, infinite, eternal, and changeless; the effect, time-space and transcendental but ever changing, always growing. (1126.2) 102:7.2 God is the one and only self-caused fact in the universe. He is the secret of the order, plan, and purpose of the whole creation of things and beings. The everywhere-changing universe is regulated and stabilized by absolutely unchanging laws, the habits of an unchanging God. The fact of God, the divine law, is changeless; the truth of God, his relation to the universe, is a relative revelation which is ever adaptable to the constantly evolving universe. (1126.3) 102:7.3 Those who would invent a religion without God are like those who would gather fruit without trees, have children without parents. You cannot have effects without causes; only the I AM is causeless. The fact of religious experience implies God, and such a God of personal experience must be a personal Deity. You cannot pray to a chemical formula, supplicate a mathematical equation, worship a hypothesis, confide in a postulate, commune with a process, serve an abstraction, or hold loving fellowship with a law. (1126.4) 102:7.4 True, many apparently religious traits can grow out of nonreligious roots. Man can, intellectually, deny God and yet be morally good, loyal, filial, honest, and even idealistic. Man may graft many purely humanistic branches onto his basic spiritual nature and thus apparently prove his contentions in behalf of a godless religion, but such an experience is devoid of survival values, God-knowingness and God-ascension. In such a mortal experience only social fruits are forthcoming, not spiritual. The graft determines the nature of the fruit, notwithstanding that the living sustenance is drawn from the roots of original divine endowment of both mind and spirit. (1126.5) 102:7.5 The intellectual earmark of religion is certainty; the philosophical characteristic is consistency; the social fruits are love and service. (1126.6) 102:7.6 The God-knowing individual is not one who is blind to the difficulties or unmindful of the obstacles which stand in the way of finding God in the maze of superstition, tradition, and materialistic tendencies of modern times. He has encountered all these deterrents and triumphed over them, surmounted them by living faith, and attained the highlands of spiritual experience in spite of them. But it is true that many who are inwardly sure about God fear to assert such feelings of certainty because of the multiplicity and cleverness of those who assemble objections and magnify difficulties about believing in God. It requires no great depth of intellect to pick flaws, ask questions, or raise objections. But it does require brilliance of mind to answer these questions and solve these difficulties; faith certainty is the greatest technique for dealing with all such superficial contentions. (1127.1) 102:7.7 If science, philosophy, or sociology dares to become dogmatic in contending with the prophets of true religion, then should God-knowing men reply to such unwarranted dogmatism with that more farseeing dogmatism of the certainty of personal spiritual experience, “I know what I have experienced because I am a son of I AM.” If the personal experience of a faither is to be challenged by dogma, then this faith-born son of the experiencible Father may reply with that unchallengeable dogma, the statement of his actual sonship with the Universal Father. (1127.2) 102:7.8 Only an unqualified reality, an absolute, could dare consistently to be dogmatic. Those who assume to be dogmatic must, if consistent, sooner or later be driven into the arms of the Absolute of energy, the Universal of truth, and the Infinite of love. (1127.3) 102:7.9 If the nonreligious approaches to cosmic reality presume to challenge the certainty of faith on the grounds of its unproved status, then the spirit experiencer can likewise resort to the dogmatic challenge of the facts of science and the beliefs of philosophy on the grounds that they are likewise unproved; they are likewise experiences in the consciousness of the scientist or the philosopher. (1127.4) 102:7.10 Of God, the most inescapable of all presences, the most real of all facts, the most living of all truths, the most loving of all friends, and the most divine of all values, we have the right to be the most certain of all universe experiences. 8. The Evidences of Religion (1127.5) 102:8.1 The highest evidence of the reality and efficacy of religion consists in the fact of human experience; namely, that man, naturally fearful and suspicious, innately endowed with a strong instinct of self-preservation and craving survival after death, is willing fully to trust the deepest interests of his present and future to the keeping and direction of that power and person designated by his faith as God. That is the one central truth of all religion. As to what that power or person requires of man in return for this watchcare and final salvation, no two religions agree; in fact, they all more or less disagree. (1127.6) 102:8.2 Regarding the status of any religion in the evolutionary scale, it may best be judged by its moral judgments and its ethical standards. The higher the type of any religion, the more it encourages and is encouraged by a constantly improving social morality and ethical culture. We cannot judge religion by the status of its accompanying civilization; we had better estimate the real nature of a civilization by the purity and nobility of its religion. Many of the world’s most notable religious teachers have been virtually unlettered. The wisdom of the world is not necessary to an exercise of saving faith in eternal realities. (1127.7) 102:8.3 The difference in the religions of various ages is wholly dependent on the difference in man’s comprehension of reality and on his differing recognition of moral values, ethical relationships, and spirit realities. (1127.8) 102:8.4 Ethics is the external social or racial mirror which faithfully reflects the otherwise unobservable progress of internal spiritual and religious developments. Man has always thought of God in the terms of the best he knew, his deepest ideas and highest ideals. Even historic religion has always created its God conceptions out of its highest recognized values. Every intelligent creature gives the name of God to the best and highest thing he knows.* (1128.1) 102:8.5 Religion, when reduced to terms of reason and intellectual expression, has always dared to criticize civilization and evolutionary progress as judged by its own standards of ethical culture and moral progress. (1128.2) 102:8.6 While personal religion precedes the evolution of human morals, it is regretfully recorded that institutional religion has invariably lagged behind the slowly changing mores of the human races. Organized religion has proved to be conservatively tardy. The prophets have usually led the people in religious development; the theologians have usually held them back. Religion, being a matter of inner or personal experience, can never develop very far in advance of the intellectual evolution of the races. (1128.3) 102:8.7 But religion is never enhanced by an appeal to the so-called miraculous. The quest for miracles is a harking back to the primitive religions of magic. True religion has nothing to do with alleged miracles, and never does revealed religion point to miracles as proof of authority. Religion is ever and always rooted and grounded in personal experience. And your highest religion, the life of Jesus, was just such a personal experience: man, mortal man, seeking God and finding him to the fullness during one short life in the flesh, while in the same human experience there appeared God seeking man and finding him to the full satisfaction of the perfect soul of infinite supremacy. And that is religion, even the highest yet revealed in the universe of Nebadon — the earth life of Jesus of Nazareth. (1128.4) 102:8.8 [Presented by a Melchizedek of Nebadon.]

Ben and Sam revisit their discussion of early-season statistics to see whether potential trends held up.

In pursuit of the wildfire source, the Elements fight their way across a pit of chaos demons before facing down with the source itself.

UI reseachers develop technique to better view 3-D microscopy of biological tissues.

Consider again our systems view of the diffraction effects on an optical imaging system as depicted in Fig. 1. In our earlier discussion we had considered ideal, diffraction-limited optical systems that convert spherical waves incident on the entrance pupil originating at object position (xo, yo) into spherical waves leaving the exit pupil focused on image position (Mxo,Myo).

Dr. Michael Cleary discusses this work on the role of chromosomal aberrations in causing cancer and its implications for cancer treatment. (September 18, 2008)

Die Entstehung struktureller Chromosomenaberrationen in somatischen Zellen ist von besonderem biologischem Interesse, da Aberrationen mit Tumorgenese in Verbindung gebracht werden. Wie wir heute wissen, sind strukturelle Chromosomenaberrationen die Folge fehlerhafter Doppelstrangbruch (DSB)-Reparatur, wobei im einfachsten Fall die Enden von zwei (oder mehr) Bruchstellen durch so genannte nichthomologe Endverknüpfung in falscher Kombination verknüpft werden. Bis heute ist jedoch unklar, inwieweit die Kernarchitektur - das heißt die Positionierung der Chromosomen im Zellkern - die Wahrscheinlichkeit einer Aberrationsentstehung beeinflusst. Um Hinweise über den Einfluss der Kernarchitektur auf die Entstehung von Austausch-aberrationen zu gewinnen, bietet es sich an, Untersuchungen in einem Modellorganismus mit vergleichbar geringer Komplexität durchzuführen. Die Hefe Saccharomyces cerevisiae ist dazu sehr geeignet, da die Kernarchitektur in diesem Organismus recht gut charakterisiert ist. Die Interphasechromosomen der Hefe nehmen eine Rabl-ähnliche Konfiguration ein, bei der alle Zentromere in der Nähe der Zellkernperipherie in einer Rosettenstruktur als cluster angeordnet sind, und die in mehreren clustern vorliegenden Telomere präferentiell am gegenüberliegenden Pol an der Kernmembran verankert sind. Die Wahrscheinlichkeit interchromosomaler Interaktionen sollte daher im Bereich der Zentromere und Telomere am höchsten sein. In der vorliegenden Arbeit wurde der Einfluss der Zellkernarchitektur auf die Aberrations-entstehung in zwei unterschiedlichen experimentellen Ansätzen in Hefe untersucht. Im ersten Ansatz wurde eine Kartierung von Translokations-Bruchpunkten durchgeführt, um anhand des Verteilungsmusters Aussagen über die Wahrscheinlichkeit der Entstehung von Austausch-aberrationen machen zu können. Dazu stand aus Vorarbeiten eine Kollektion von 16 Klonen Rekombinations-defizienter Hefestämme (rad52- bzw. rad54-Mutanten) zur Verfügung, die strahleninduzierte strukturelle Chromosomenaberrationen tragen (mit insgesamt 35 beteiligten Chromosomen). Die Chromosomen V und VIII waren bei diesen Klonen an der Ausbildung strahleninduzierter Aberrationen häufiger beteiligt, als aufgrund ihrer Länge zu erwarten war, ohne dass hierfür ein Grund ausgemacht werden konnte. Die Bruchpunkte auf den Chromosomen V und VIII, sowie ihren jeweiligen Translokationspartnern, wurden mit Hilfe zwei verschiedener Methoden kartiert, die jeweils auf den Nachweis der An- und Abwesenheit spezifischer Sequenzbereiche (Sonden) auf den aberranten chromosomalen Banden abzielten. Dabei zeigte sich, dass von den insgesamt 17 kartierten Bruchpunkten sieben Zentromer-nah (bis zu 100 kb vom Zentromer entfernt), drei Telomer-nah (bis zu 12 kb vom Telomer entfernt) und sieben in der interstitiellen Region liegen. Bruchpunkte in der interstitiellen Region zeigten sich also signifikant unterrepräsentiert, so dass hier auf einen Einfluss der Zellkernarchitektur auf die Aberrationsentstehung zu schließen ist. Im zweiten experimentellen Ansatz wurde ein Modellsystem in Hefe entwickelt, mit dem sich der Einfluss der initialen Position von DSB auf die Entstehungswahrscheinlichkeit inter-chromosomaler Fehlverknüpfung systematisch untersuchen lässt. Dazu wurde eine Serie von Hefestämmen hergestellt, in denen gleichzeitig jeweils zwei DSB enzymatisch mittels HO-Endonuklease induziert werden können. Die entsprechenden Enzymschnittstellen (HOcs) wurden dabei an verschiedenen chromosomalen Positionen eingesetzt, die aufgrund ihrer Entfernung zu Zentromer und/oder Telomer im Falle eines Kernarchitektureinflusses unterschiedliche Interaktionswahrscheinlichkeiten haben sollten. Nach DSB-Induktion sowie Reparatur wurde mittels PCR-Analyse untersucht, wie häufig es in den einzelnen Stämme im Zuge der Reparatur zu einer Fehlverknüpfung der Enden gekommen war. Dabei konnte gezeigt werden, dass die intra- und intermolekulare Verknüpfung bei der Reparatur in allen getesteten Bruchort-Konstellationen etwa gleich häufig war, d.h. es wurde kein Einfluss der Kernarchitektur auf die Aberrationsentstehung festgestellt. Dieses Ergebnis passt gut zu Befunden einer neueren Arbeit, in der gezeigt werden konnte, dass sich nach Induktion multipler DSB nur wenige RAD52-Foci im Zellkern bilden, die als Reparaturzentren/ „-fabriken“ erklärt werden. Entsprechend diesem Modell können damit auch initial weiter voneinander entfernte DSB zu Austauschaberrationen führen, da die jeweiligen Enden in den wenigen „Fabriken“ zusammentreffen können. Als Ursache für die in beiden Systemen erzielten unterschiedlichen Ergebnisse könnten also entweder die unterschiedlichen genetischen Hintergründe (Rekombinations-defizient im Vergleich zu Rekombinations-profizient) oder die unterschiedliche Struktur der Bruchenden (strahlen-induziert im Vergleich zu Endonuklease-induziert) in Betracht kommen.

Background: The analysis of complex cytogenetic databases of distinct leukaemia entities may help to detect rare recurring chromosome aberrations, minimal common regions of gains and losses, and also hot spots of genomic rearrangements. The patterns of the karyotype alterations may provide insights into the genetic pathways of disease progression. Results: We developed a simplified computer readable cytogenetic notation (SCCN) by which chromosome findings are normalised at a resolution of 400 bands. Lost or gained chromosomes or chromosome segments are specified in detail, and ranges of chromosome breakpoint assignments are recorded. Software modules were written to summarise the recorded chromosome changes with regard to the respective chromosome involvement. To assess the degree of karyotype alterations the ploidy levels and numbers of numerical and structural changes were recorded separately, and summarised in a complex karyotype aberration score (CKAS). The SCCN and CKAS were used to analyse the extend and the spectrum of additional chromosome aberrations in 94 patients with Philadelphia chromosome positive (Ph-positive) acute lymphoblastic leukemia ( ALL) and secondary chromosome anomalies. Dosage changes of chromosomal material represented 92.1% of all additional events. Recurring regions of chromosome losses were identified. Structural rearrangements affecting ( peri) centromeric chromosome regions were recorded in 24.6% of the cases. Conclusions: SCCN and CKAS provide unifying elements between karyotypes and computer processable data formats. They proved to be useful in the investigation of additional chromosome aberrations in Ph-positive ALL, and may represent a step towards full automation of the analysis of large and complex karyotype databases.

Chromosomal in situ suppression (CISS)-hybridization of biotinylated phage DNA-library inserts from sorted human chromosomes was used to decorate chromosomes 1 and 7 specifically from pter to qter and to detect structural aberrations of these chromosomes in irradiated human peripheral lymphocytes. In addition, probe pUC1.77 was used to mark the Iq12 subregion in normal and aberrant chromosomes 1. Low LET radiation (60Co--rays; 1.17 and 1.33 MeV) of lymphocyte cultures was performed with various doses (D = 0, 2, 4, 8 Gy) 5 h after stimulation with phytohaemagglutinin. Irradiated cells were cultivated for an additional 67 h before Colcemid arrested metaphase spreads were obtained. Aberrations of the specifically stained chromosomes, such as deletions, dicentrics, and rings, were readily scored after in situ hybridization with either the 1q12 specific probe or DNA-library inserts. By the latter approach, translocations of the specifically stained chromosomes could also be reliably assessed. A linear increase of the percentage of specifically stained aberrant chromosomes was observed when plotted as a function of the square of the dose D. A particular advantage of this new approach is provided by the possibility to delineate numerical and structural chromosome aberrations directly in interphase nuclei. These results indicate that cytogenetic monitoring of ionizing radiation may be considerably facilitated by CISS-hybridization.

Plasmid clones containing up to 94 kilobases of single-copy DNA from band q22.3 of chromosome 21 and a complete pool of insert DNA from a chromosome 21 recombinant library have been used to rapidly detect numerical and structural aberrations of chromosome 21 by in situ hybridization in both metaphase and interphase cells. A trisomic karyotype, diagnostic of Down syndrome, is readily detected in nonmitotic cells because the majority of their nuclei exhibit three discrete foci of hybridization, in contrast to normal diploid cells, which show two foci. Chromosomal translocations involving chromosome 21 sequences were also detected with these probes, and the intranuclear location of 21q22.3 DNA sequences in "normal" human brain neurons was established with the plasmid DNA probe set. These results suggest that chromosome 21-specific probes may have utility in clinical diagnostics, especially by facilitating the direct analysis of interphase cells.

Chromosome aberrations in two glioma cell lines were analyzed using biotinylated DNA library probes that specifically decorate chromosomes 1, 4, 7, 18 and 22 from pter to qter. Numerical changes, deletions and rearrangements of these chromosomes were radily visualized in metaphase spreads, as well as in early prophase and interphase nuclei. Complete chromosomes, deleted chromosomes and segments of translocated chromosomes were rapidly delineated in very complex karyotypes. Simultaneous hybridizations with additional subregional probes were used to further define aberrant chromosomes. Digital image analysis was used to quantitate the total complement of specific chromosomal DNAs in individual metaphase and interphase cells of each cell line. In spite of the fact that both glioma lines have been passaged in vitro for many years, an under-representation of chromosome 22 and an over-representation of chromosome 7 (specifically 7p) were observed. These observations agree with previous studies on gliomas. In addition, sequences of chromosome 4 were also found to be under-represented, especially in TC 593. These analyses indicate the power of these methods for pinpointing chromosome segments that are altered in specific types of tumors.

The localization of chromosome 18 in human interphase nuclei is demonstrated by use of radioactive and nonradioactive in situ hybridization techniques with a DNA clone designated L1.84. This clone represents a distinct subpopulation of the repetitive human alphoid DNA family, located in the centric region of chromosome 18. Under stringent hybridization conditions hybridization of L1.84 is restricted to chromosome 18 and reflects the number of these chromosomes present in the nuclei, namely, two in normal diploid human cells and three in nuclei from cells with trisomy 18. Under conditions of low stringency, cross-hybridization with other subpopulations of the alphoid DNA family occurs in the centromeric regions of the whole chromosome complement, and numerous hybridization sites are detected over interphase nuclei. Detection of chromosome-specific target DNAs by non-radioactive in situ hybridization with appropriate DNA probes cloned from individual chromosomal subregions presents a rapid means of identifying directly numerical or even structural chromosome aberrations in the interphase nucleus. Present limitations and future applications of interphase cytogenetics are discussed.

Sat, 1 Jan 1977 12:00:00 +0100 https://epub.ub.uni-muenchen.de/9306/1/9306.pdf Zimmer, J.; Cremer, Thomas; Cremer, Christoph; Zorn, Chri