Podcasts about Los Angeles

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    Latest podcast episodes about Los Angeles

    We're Here to Help
    242: The First Annual Helpies

    We're Here to Help

    Play Episode Listen Later Dec 22, 2025 67:12


    Live from Los Angeles, it's the first-ever "Helpies!" Hosted by Jake and Gareth, the show features appearances from some of the best callers in We're Here to Help history.See images from the episode here: https://www.heretohelppod.com/post/episode-242Want to call in? Email your question to helpfulpod@gmail.com.PATREON: https://patreon.com/heretohelppodMERCH: heretohelppod.comINSTAGRAM: @HereToHelpPodIf you're enjoying the show, make sure to rate We're Here to Help 5-Stars on Apple Podcasts.Advertise on We're Here to Help via Gumball.fmSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    BADLANDS: SPORTSLAND
    Chris Farley: Raging Bulls, Insatiable Appetites, Dead Comics, and a Four-Day Plunge off the Edge

    BADLANDS: SPORTSLAND

    Play Episode Listen Later Dec 22, 2025 35:39


    Everything about Chris Farley was larger than life. His comedy, his laughs, the risks he took in front of a live studio audience – they were all bigger than anyone else's. So were his appetites. Not just for performance, but for life. He plowed through a plate glass window, 15 stories above downtown Chicago. He was kicked out of college for burning down a girl's house. He disappeared with two Playboy models in Los Angeles and woke up the next morning in Hawaii. He modeled his career on an iconic dead comedian – even following the comic's path, straight to an early grave. To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

    How Long Gone
    886. - Chris & Jason

    How Long Gone

    Play Episode Listen Later Dec 22, 2025 60:15


    One-on-one pod today, Chris is in New York, and Jason is home in Los Angeles. We chat about Bowen Yang leaving SNL, rapper TI is a comedian now, we're neck and neck with Joe Budden for the number of podcast episodes, new Epstein flicks dropped, and there is an odd lack of something in them, the downsides of island ownership, what Chris Tucker brings to the table in Epstein's friend group, the Counting Crows documentary, Erika Kirk going mode Righteous Gemstones a bit too early, Slayyyter Lyrics, and we dine at Bistrot Ha's in New York, and sushi spot Morihiro in LA. twitter.com/donetodeath twitter.com/themjeans howlonggone.com Learn more about your ad choices. Visit megaphone.fm/adchoices

    Preacher Boys Podcast
    Clinical Psychologist Reveals How Trauma Can Trigger a Fawn Response | Dr. Ingrid Clayton

    Preacher Boys Podcast

    Play Episode Listen Later Dec 22, 2025 63:26 Transcription Available


    Grab a copy of Dr. Ingrid Clayton's book here — https://amzn.to/48Semw4Want to listen on Audible? Get a free Premium Plus trial here: https://www.amazon.com/hz/audible/mlp(As an Amazon associate, I receive a small commission on purchases made through the links on this channel. Thanks for making this show possible!)Ingrid Clayton, PhD, is a writer and clinical psychologist in private practice in Los Angeles, California. She's the author of Fawning: a powerful to the often-overlooked piece of the fight-flight-freeze reaction to trauma, Believing Me: Healing from Narcissistic Abuse and Complex Trauma, where she uncovers her personal experience of childhood trauma from a psychologist's perspective, and Recovering Spirituality: Achieving Emotional Sobriety in Your Spiritual Practice. Ingrid is a regular contributor to Psychology Today, where her article “What is Self-Gaslighting?” is considered an essential read!With a Masters in transpersonal psychology and a PhD in clinical psychology, Ingrid has a holistic approach to psychotherapy, incorporating trauma-informed modalities like Somatic Experiencing, EMDR, and other experiential ways of working with the nervous system. Ingrid has been using a relational approach to therapy since 2004, bringing her whole self to the work—including her personal experience, intuition, and education. This enables her to be in real connection and collaboration with her clients.✖️✖️✖️Support the Show: Patreon.com/PreacherBoys✖️✖️✖️If you or someone you know has experienced abuse, visit courage365.org/need-help✖️✖️✖️CONNECT WITH THE SHOW:preacherboyspodcast.comhttps://www.youtube.com/@PreacherBoyshttps://www.facebook.com/preacherboysdoc/https://twitter.com/preacherboysdochttps://www.instagram.com/preacherboyspodhttps://www.tiktok.com/@preacherboyspodTo connect with a community that shares the Preacher Boys Podcast's mission to expose abuse in the IFB, join the OFFICIAL Preacher Boys Facebook Group: https://www.facebook.com/groups/1403898676438188/✖️✖️✖️The content presented in this video is for informational and educational purposes only. All individuals and entities discussed are presumed innocent until proven guilty through due legal process. The views and opinions expressed are those of the speakers.✖️✖️✖️Music by Lou Ridley — “Bible Belt” | Used with permission under license.This episode is sponsored by/brought to you by BetterHelp. Give online therapy a try at betterhelp.com/PreacherBoys and get on your way to being your best self.Support this podcast at — https://redcircle.com/preacher-boys-podcast/donationsAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

    SH!TPOST
    064: Who the Hell is Bill Maher? feat. Will Weldon

    SH!TPOST

    Play Episode Listen Later Dec 22, 2025 184:47


    With over four decades in show business, you might think that Bill Maher needs no introduction. But Posting Through Itcovers MAGA and the far right, and if you have perused politics-heavy corners of social media lately, you know that Maher has emerged as one of the most polarizing commentators of Trump's second term. No longer beloved by liberals, Maher has hosted a bizarre rotation of MAGA friendly guests, including Kid Rock, RFK Jr. and Marjorie Taylor Greene. He also punches left on everything from vaccines to Gaza. Jared and Mike welcome comedian Will Weldon on for this three-hour Holiday spectacular. You will leave learning about everything from Maher's psychedelic, short-lived Showtime show "Hard Knocks" to his alleged relationships with Los Angeles-area sex workers. Tune in and find out who is out on these streets rooting for the planes on 9/11!Links for Will:Listen to his podcast, I Hate Bill Maher: https://www.patreon.com/cw/IHateBillMaherCheck out Will's website: https://www.oldmanweldon.comLinks for us:Save 20% when you reserve your copy of Mike's book with the code "STRANGE20": https://www.hachettebookgroup.com/titles/michael-edison-hayden/strange-people-on-the-hill/9781645030607/?lens=bold-type-books

    The TASTE Podcast
    705: The Year in Los Angeles Restaurants with Jenn Harris of the Los Angeles Times & Jordan Okun and Max Shapiro of Air Jordan

    The TASTE Podcast

    Play Episode Listen Later Dec 22, 2025 73:25


    We wanted to close the year by talking about the year in dining in Los Angeles, a city that always inspires with new openings and truly singular legendary spots. We are joined by Jenn Harris, a columnist and critic for the Food section of the Los Angeles Times. The paper just released its annual 101 Best Restaurants in Los Angeles list, and we talk about many of the selections. Also on the show, we speak with Jordan Okun and Max Shapiro, the team behind the terrific podcast Air Jordan. Jordan and Max are always honest, and we have a great time discussing the year in restaurants in LA. And to kickoff the show, Aliza and Matt share some memorable meals from Los Angeles this year. Have a future guest request? A restaurant we should visit? Take the ⁠⁠This Is TASTE listener survey⁠⁠. We really appreciate the feedback. Learn more about your ad choices. Visit megaphone.fm/adchoices

    No Lie with Brian Tyler Cohen
    Trump's Epstein file release botched beyond repair

    No Lie with Brian Tyler Cohen

    Play Episode Listen Later Dec 21, 2025 64:44


    Trump's Epstein file release gets botched beyond repair. Brian interviews Ro Khanna about the DOJ failing to comply with the law, Bernie Sanders about Republicans blocking the ACA extension, Jasmine Crockett about her run for Senate in Texas, and Hakeem Jeffries about how House Democrats outsmarted Mike Johnson on yet another discharge petition.Shop merch: https://briantylercohen.com/shopYouTube: https://www.youtube.com/user/briantylercohenTwitter: https://twitter.com/briantylercohenFacebook: https://www.facebook.com/briantylercohenInstagram: https://www.instagram.com/briantylercohenPatreon: https://www.patreon.com/briantylercohenNewsletter: https://www.briantylercohen.com/sign-upWritten by Brian Tyler CohenProduced by Sam GraberRecorded in Los Angeles, CASee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    iFanboy.com Comic Book Podcast
    2025 All Media Year End Roundup

    iFanboy.com Comic Book Podcast

    Play Episode Listen Later Dec 21, 2025 178:30


    It's the 21st annual iFanboy All Media Year End Roundup! Conor Kilpatrick, Josh Flanagan, and special guest Ron Richards discuss some of what they enjoyed in media in this, the year that was 2025. Movies, television, music, podcasts, books, and comics — it's all here! Note: Timecodes are subject to change depending on dynamic ad insertion by the distributor. Running Time: 02:54:30 Movies:00:02:35 – The Year in Movies00:06:19 – Sinners00:09:45 – One Battle After Another00:12:30 – Superman00:14:43 – Hamnet00:16:39 – Caught Stealing00:19:24 – The Naked Gun00:22:46 – Wake Up Dead Man: A Knives Out Mystery00:26:03 – Lurker00:27:24 – Mickey 1700:28:37 – Train Dreams00:31:26 – Jay Kelly00:34:02 – Blue Moon00:37:36 – Nouvelle Vague00:40:48 – Nuremberg00:44:58 – Weapons Television:00:47:45 – The Year in Television00:49:07 – The Pitt00:50:31 – The Gilded Age00:54:25 – Slow Horses00:57:16 – The Lowdown01:00:28 – The Beast in Me01:03:22 – English Teacher01:05:13 – Andor: A Star Wars Story01:07:32 – Alien: Earth01:11:16 – Paradise01:12:56 – Death By Lightning01:19:47 – The Residence01:21:38 – The Studio01:23:05 – Dept. Q01:25:59 – Dying For Sex01:28:49 – The Conners Music:01:32:54 – “Who Is the Sky?” by David Byrne01:33:34 – Who is the Sky? Tour by David Byrne at Radio City Music Hall in New York, New York01:34:30 – Hamilton: An American Musical at Richard Rodgers Theatre in New York, New York 01:38:22 – Suffs The Musical at Hollywood Pantages Theatre in Los Angeles, California01:39:35 – Pulp Live 2025 by Pulp at Queens Forest Hills Stadium in Forest Hills, New York01:41:51 – “God Save The Gun” by Militarie Gun01:43:08 – “Antidepressants” by Suede01:44:28 – “Alive in the Catacombs” by Queens of the Stone Age01:45:45 – The Catacombs Tour by Queens of the Stone Age at Boch Center Wang Theatre in Boston, Massachusetts01:49:05 – Oasis: Live '25 by Oasis at The Rose Bowl in Pasadena, California01:50:14 – “Yell at Cloud” by PLOSIVS Books:01:51:49 – The Year in Books01:52:20 – “Lorne: The Man Who Invented Saturday Night Live” by Susan Morrison01:55:20 – “Lollapalooza: The Uncensored Story of Alternative Rock's Wildest Festival” by Richard Bienstock & Tom Beaujour01:58:41 – “All Systems Red: The Murderbot Diaries” By Martha Wells02:00:10 – “Gai-Jin: The Epic Novel of the Birth of Modern Japan” by James Clavell02:03:30 – “Perfidia: A Novel” by James Ellroy02:05:16 – “The Ship Beneath the Ice: The Discovery of Shackleton's Endurance” by Mensun Bound02:09:42  – “To Kill a Troubadour: A Mystery of the French Countryside” by Martin Walker02:10:34 – “The Name of This Band is R.E.M.: A Biography” by Peter Ames Carlin02:14:21 – “The Impossible Fortune: A Thursday Murder Club Mystery” by Richard Osman02:15:22 – The Patrick Kenzie and Angela Gennaro Series by Dennis Lehane Podcasts:02:18:34 – “The Town” with Matt Belloni02:20:48 – “Blank Check” with Griffin Newman & David Sims02:23:29 – “The Rest is Entertainment” with Marina Hyde & Richard Osman02:24:54 – “Gone South” with Jed Lipinski02:27:44 – “Mike & Tom Eat Snacks” with Michael Ian Black & Tom Cavanagh02:30:21 – “Fly on the Wall” with Dana Carvey & David Spade02:31:46 – “Nudgecast: The Official Podcast of Nudge Magazine” with Ian Jacoby & Shane Told Comics:02:38:16 – Batman & Robin: Year One02:39:11 – Wonder Woman02:40:29 – Absolute Wonder Woman02:41:19 – Assorted Crisis Events02:43:04 – Daredevil: Cold Day in Hell02:43:43 – Usagi Yojimbo02:44:31 – Fantastic Four02:45:39 – Uncanny Valley02:46:41 – Redcoat02:47:40 – Supergirl More From Ron Richards:• Listen to Android Faithful!• If you're into pinball, check out Scorbit! Brought To You By: iFanboy Patrons  iFanboy T-Shirts and Merch Music:“Mele Kalikimaka [feat. Shannon McGill]”Slowey and The Boats LISTEN TO THE IFANBOY 2025 ALL MEDIA YEAR END PLAYLIST! Learn more about your ad choices. Visit megaphone.fm/adchoices

    Believe Her
    Happier with Gretchen Rubin: Did We Get Everything Done on Our “25 for '25” Lists?

    Believe Her

    Play Episode Listen Later Dec 21, 2025 37:22


    Gretchen Rubin is HAPPIER, and she wants you to be happier too. The #1 bestselling author of The Happiness Project and Better Than Before gets more personal than ever as she brings her practical, manageable advice about happiness and good habits to this lively, thought-provoking podcast. Gretchen’s cohost and guinea pig is her younger sister, Elizabeth Craft, a TV writer and producer living in Los Angeles, who (lovingly) refers to Gretchen as her happiness bully. As part of “Design Your Year,” each of us made a list of 25 things we wanted to accomplish in 2025; here, we report on what we got done—and what we didn’t. Resources & links related to this episode: Happier in Hollywood Substack Simon Haisell's Footnotes and Tangents Allie Coyle Photography The Earth Room created by American artist Walter De Maria Click here to find everything related to the Design Your Year challenge If you want to hear more episodes, follow Happier with Gretchen Rubin wherever you get your podcasts, or head to: https://lemonada.lnk.to/happierfdSee omnystudio.com/listener for privacy information.

    The Suga
    Happier with Gretchen Rubin: Did We Get Everything Done on Our “25 for '25” Lists?

    The Suga

    Play Episode Listen Later Dec 21, 2025 37:22


    Gretchen Rubin is HAPPIER, and she wants you to be happier too. The #1 bestselling author of The Happiness Project and Better Than Before gets more personal than ever as she brings her practical, manageable advice about happiness and good habits to this lively, thought-provoking podcast. Gretchen’s cohost and guinea pig is her younger sister, Elizabeth Craft, a TV writer and producer living in Los Angeles, who (lovingly) refers to Gretchen as her happiness bully. As part of “Design Your Year,” each of us made a list of 25 things we wanted to accomplish in 2025; here, we report on what we got done—and what we didn’t. Resources & links related to this episode: Happier in Hollywood Substack Simon Haisell's Footnotes and Tangents Allie Coyle Photography The Earth Room created by American artist Walter De Maria Click here to find everything related to the Design Your Year challenge If you want to hear more episodes, follow Happier with Gretchen Rubin wherever you get your podcasts, or head to: https://lemonada.lnk.to/happierfdSee omnystudio.com/listener for privacy information.

    Blind Plea
    Happier with Gretchen Rubin: Did We Get Everything Done on Our “25 for '25” Lists?

    Blind Plea

    Play Episode Listen Later Dec 21, 2025 37:22


    Gretchen Rubin is HAPPIER, and she wants you to be happier too. The #1 bestselling author of The Happiness Project and Better Than Before gets more personal than ever as she brings her practical, manageable advice about happiness and good habits to this lively, thought-provoking podcast. Gretchen’s cohost and guinea pig is her younger sister, Elizabeth Craft, a TV writer and producer living in Los Angeles, who (lovingly) refers to Gretchen as her happiness bully. As part of “Design Your Year,” each of us made a list of 25 things we wanted to accomplish in 2025; here, we report on what we got done—and what we didn’t. Resources & links related to this episode: Happier in Hollywood Substack Simon Haisell's Footnotes and Tangents Allie Coyle Photography The Earth Room created by American artist Walter De Maria Click here to find everything related to the Design Your Year challenge If you want to hear more episodes, follow Happier with Gretchen Rubin wherever you get your podcasts, or head to: https://lemonada.lnk.to/happierfd See omnystudio.com/listener for privacy information.

    No One is Coming to Save Us
    Happier with Gretchen Rubin: Did We Get Everything Done on Our “25 for '25” Lists?

    No One is Coming to Save Us

    Play Episode Listen Later Dec 21, 2025 37:22


    Gretchen Rubin is HAPPIER, and she wants you to be happier too. The #1 bestselling author of The Happiness Project and Better Than Before gets more personal than ever as she brings her practical, manageable advice about happiness and good habits to this lively, thought-provoking podcast. Gretchen’s cohost and guinea pig is her younger sister, Elizabeth Craft, a TV writer and producer living in Los Angeles, who (lovingly) refers to Gretchen as her happiness bully. As part of “Design Your Year,” each of us made a list of 25 things we wanted to accomplish in 2025; here, we report on what we got done—and what we didn’t. Resources & links related to this episode: Happier in Hollywood Substack Simon Haisell's Footnotes and Tangents Allie Coyle Photography The Earth Room created by American artist Walter De Maria Click here to find everything related to the Design Your Year challenge If you want to hear more episodes, follow Happier with Gretchen Rubin wherever you get your podcasts, or head to: https://lemonada.lnk.to/happierfd See omnystudio.com/listener for privacy information.

    In Recovery
    Happier with Gretchen Rubin: Did We Get Everything Done on Our “25 for '25” Lists?

    In Recovery

    Play Episode Listen Later Dec 21, 2025 37:22


    Gretchen Rubin is HAPPIER, and she wants you to be happier too. The #1 bestselling author of The Happiness Project and Better Than Before gets more personal than ever as she brings her practical, manageable advice about happiness and good habits to this lively, thought-provoking podcast. Gretchen’s cohost and guinea pig is her younger sister, Elizabeth Craft, a TV writer and producer living in Los Angeles, who (lovingly) refers to Gretchen as her happiness bully. As part of “Design Your Year,” each of us made a list of 25 things we wanted to accomplish in 2025; here, we report on what we got done—and what we didn’t. Resources & links related to this episode: Happier in Hollywood Substack Simon Haisell's Footnotes and Tangents Allie Coyle Photography The Earth Room created by American artist Walter De Maria Click here to find everything related to the Design Your Year challenge If you want to hear more episodes, follow Happier with Gretchen Rubin wherever you get your podcasts, or head to: https://lemonada.lnk.to/happierfd See omnystudio.com/listener for privacy information.

    The Paranormal 60
    Bombshell: The Night Bobby Kennedy Killed Marilyn Monroe - TRUE CRIME REWIND - Mysteries, Mayhem & Merlot

    The Paranormal 60

    Play Episode Listen Later Dec 21, 2025 58:44


    TRUE CRIME REWIND On August 5, 1962, Hollywood's brightest star, Marilyn Monroe, was found dead in her Los Angeles home. Officially ruled a suicide, her death has been shrouded in conspiracy theories, speculation, and unanswered questions. In this episode, we explore Rothmiller and Thompson's shocking assertions that link the legendary actress's death to Robert F. Kennedy, the enigmatic and ambitious younger brother of President John F. Kennedy. Was Marilyn Monroe's death truly a tragic overdose, or was it a calculated act of silencing a woman who knew too much? Get the book here - https://amzn.to/3KmU5So Bombshell: The Night Bobby Kennedy Killed Marilyn Monroe - Mysteries, Mayhem & Merlot Check out the merch, blog, buy the book and so much more! mysteriesmayhemandmerlot.net WHERE'S WINNIE! - https://linktr.ee/WinnieSchrader Check out Winnie's Linktree for everything Winnie! From merch for Paranormal 60, Love+Lotus Tarot & Mysteries, Mayhem & Merlot to digital designs with WS Media & more! Find the Paranormal 60 Podcast & Mysteries, Mayhem & Merlot Podcasts on Rumble Use our link & Sign Up Today! - https://rumble.com/register/Paranormal60Network IF YOU NEED HELP PLEASE CONTACT Call or Text to 988 Chat online at https://988lifeline.org/ PLEASE SUPPORT THE ADVERTISERS THAT SUPPORT THIS SHOW GIVE the GIFT of an EXPERIENCE this Holiday Season! Love & Lotus Tarot with Winnie Schrader - ⁠⁠⁠⁠http://lovelotustarot.com/⁠⁠⁠⁠  Paranormal Mysteries EVENT: https://www.darknessradio.com/darknessevents/ Check out the merch, blog, buy the book and so much more! mysteriesmayhemandmerlot.net WHERE'S WINNIE! - https://linktr.ee/WinnieSchrader Check out Winnie's Linktree for everything Winnie! From merch for Paranormal 60, Love+Lotus Tarot & Mysteries, Mayhem & Merlot to digital designs with WS Media & more! Find the Paranormal 60 Podcast & Mysteries, Mayhem & Merlot Podcasts on Rumble Use our link & Sign Up Today! - https://rumble.com/register/Paranormal60Network IF YOU NEED HELP PLEASE CONTACT THE CRISIS HELPLINE Domestic Violence-Drugs-Alcohol-Suicide-Sexual Abuse Call or Text to 988 Chat online at https://988lifeline.org/ PLEASE SUPPORT THE ADVERTISERS THAT SUPPORT THIS SHOW TalkSpace - Get $80 off your first month with Talkspace when you go to Talkspace.com/podcast and enter promo code SPACE80. True Classic - Step into your new home for the best clothes at True Classic ⁠www.TrueClassic.com/P60⁠ Raycon Everyday Earbuds - Save up to 30% Off at ⁠www.buyraycon.com/truecrimenetwork⁠ Cornbread Hemp - Save 30% off your first order at ⁠www.cornbreadhemp.com/P60⁠ and enter P60 into the coupon code Mint Mobile - To get your new wireless plan for just $15 a month, and get the plan shipped to your door for FREE, go to ⁠⁠⁠www.MintMobile.com/P60⁠ Cozy Earth - Begin your sleep adventure on the best bedding and sleepwear with Cozy Earth: ⁠https://cozyearth.com/⁠ use Promo Code P60 for up to 40% off savings! Love & Lotus Tarot with Winnie Schrader - ⁠⁠⁠⁠http://lovelotustarot.com/⁠⁠⁠⁠ PLEASE RATE & REVIEW MYSTERIES, MAYHEM & MERLOT PODCAST WHEREVER YOU LISTEN #MarilynMonroe #MarilynMonroeDeath #MarilynMonroeMystery #MarilynMonroeConspiracy #HollywoodTrueCrime #ClassicHollywood #CelebrityDeaths #UnsolvedMysteries #TrueCrimeRewind #TrueCrimePodcast #RFK #RobertFKennedy #KennedyConspiracy #JFKScandals #PoliticalScandals #GovernmentCoverUp #WomenSilenced #1960sHistory #OldHollywood #LosAngelesTrueCrime #FamousDeaths #PopCultureMysteries #TrueCrimeCommunity Learn more about your ad choices. Visit megaphone.fm/adchoices

    The Business of Dance
    109- Karl Flores: Grammy Performer Trainer, DOECHII, Kiana Lede, Redbull Dance, Oncloud.

    The Business of Dance

    Play Episode Listen Later Dec 21, 2025 50:32


    Interview Date: September 28th, 2025Episode Summary:Strength & conditioning coach and dance athleticism specialist Karl Flores joins the Business of Dance for a science-meets-studio deep dive. Karl traces his path from competitive dancer to Equinox trainer to founder of Movement Society in Los Angeles, explaining how structured training, recovery, and style-specific programming extend dancers' careers. He unpacks the “artist-athlete” mindset, common conditioning mistakes, injury-prevention fundamentals, and a practical training pyramid (aerobic base → strength → power). In Q&A, Karl tackles motivation, off-season vs. in-season “microdosing,” hypermobility strategies, rehab priorities, and genre needs—from ballet posture to breakers' shoulder stability—closing with how dancers can work with him online.Shownotes:(0:00) – Welcome & intro to Coach Karl Flores and his expertise(5:49) – Karl's journey from collegiate dancer to strength coach(9:05) – “Artist-Athlete” mindset: merging creativity and physicality(11:55) – Common dancer mistake: not strength training consistently(13:58) – Injury prevention through structured programs and recovery(15:36) – Ballet vs. breaking: training by style and muscle focus(17:30) – The three-tier pyramid: endurance, strength, power(20:23) – Mindset, confidence, and aligning body with intention(23:13) – Longevity: how training extends dance careers(34:12) – Off-season vs. in-season “microdosing” workout strategyBiography:Karl Flores is a Los Angeles–based strength and conditioning coach with over 10 years of experience, specializing in bridging the gap between athletic performance and dance. With a background in competitive dance, kinesiology, and exercise science, Karl is passionate about helping others unlock their fullest potential and achieve the best version of themselves through movement.Over the course of his career, Karl has worked with professional dancers, world tour performers, freestyle battle champions, and Grammy Award–winning music artists. His expertise spans injury prevention, musculoskeletal rehab, functional training, and optimizing both athletic and dance performance.Training Specialties:Injury PreventionMusculoskeletal RehabFunctional TrainingAthletic & Dance PerformanceStrength & ConditioningEducation & Certifications:B.S. in Kinesiology & Exercise Science (Physiology Minor)Certified Strength & Conditioning Specialist (CSCS)DBC Level 1Functional Movement Screen Level 1Kettlebell AthleticsTriggerpoint TherapyViPRPrecision Nutrition Level 1 (Pn1)Progressive Bodyweight TrainingDynamic Sports Performance Certified CoachKettlebell Coach University L1Functional Range Conditioning (FRCms)Functional Range Assessment (FRA)Karl's mission is simple: to empower artist-athletes with the tools, science, and confidence to perform at their highest level, while building longevity in their craft.Connect on Social Media:Instagram: https://www.instagram.com/karl.flrs/

    After 1954
    Happier with Gretchen Rubin: Did We Get Everything Done on Our “25 for '25” Lists?

    After 1954

    Play Episode Listen Later Dec 21, 2025 37:22


    Gretchen Rubin is HAPPIER, and she wants you to be happier too. The #1 bestselling author of The Happiness Project and Better Than Before gets more personal than ever as she brings her practical, manageable advice about happiness and good habits to this lively, thought-provoking podcast. Gretchen’s cohost and guinea pig is her younger sister, Elizabeth Craft, a TV writer and producer living in Los Angeles, who (lovingly) refers to Gretchen as her happiness bully. As part of “Design Your Year,” each of us made a list of 25 things we wanted to accomplish in 2025; here, we report on what we got done—and what we didn’t. Resources & links related to this episode: Happier in Hollywood Substack Simon Haisell's Footnotes and Tangents Allie Coyle Photography The Earth Room created by American artist Walter De Maria Click here to find everything related to the Design Your Year challenge If you want to hear more episodes, follow Happier with Gretchen Rubin wherever you get your podcasts, or head to: https://lemonada.lnk.to/happierfdSee omnystudio.com/listener for privacy information.

    When We Win with Maya Rupert
    Happier with Gretchen Rubin: Did We Get Everything Done on Our “25 for '25” Lists?

    When We Win with Maya Rupert

    Play Episode Listen Later Dec 21, 2025 37:22


    Gretchen Rubin is HAPPIER, and she wants you to be happier too. The #1 bestselling author of The Happiness Project and Better Than Before gets more personal than ever as she brings her practical, manageable advice about happiness and good habits to this lively, thought-provoking podcast. Gretchen’s cohost and guinea pig is her younger sister, Elizabeth Craft, a TV writer and producer living in Los Angeles, who (lovingly) refers to Gretchen as her happiness bully. As part of “Design Your Year,” each of us made a list of 25 things we wanted to accomplish in 2025; here, we report on what we got done—and what we didn’t. Resources & links related to this episode: Happier in Hollywood Substack Simon Haisell's Footnotes and Tangents Allie Coyle Photography The Earth Room created by American artist Walter De Maria Click here to find everything related to the Design Your Year challenge If you want to hear more episodes, follow Happier with Gretchen Rubin wherever you get your podcasts, or head to: https://lemonada.lnk.to/happierfdSee omnystudio.com/listener for privacy information.

    INXS: Access All Areas
    Epi237: Kick 2017 Video with Director Steve Hanft

    INXS: Access All Areas

    Play Episode Listen Later Dec 21, 2025 86:49 Transcription Available


    Kick 2017 Video with Director Steve Hanft “Watch the world argue, argue with itself, who's going to teach me peace and happiness” (Dancing on the Jetty 1983)... Never have these words and lyrics been more appropriate as all Australians try to make sense of the abhorrent terrorism at Sydney's iconic Bondi Beach. A beach with so many INXS connections that we discuss on this episode. That aside, we dedicate this episode to every person affected by this horrible crime.   We are thrilled to have Steve Hanft, the famed Californian film clip Director and early YouTube content creator, join the INXS podcast family and talk about his iconic 2017 promotional video for the song Kick, the eponymous title track commemorating the 30th anniversary of this juggernaut album's release. Having grown up with and worked on Beck's 1994 Video of the Year track “Loser”, Steve has been a mainstay in the underground and alternative music scene, producing clips for The Cure, Primal Scream and Elliot Smith. Additionally, Steve was at the forefront of YouTube with his award-winning “Sunglasses Catch", which has been named one of “The 10 Most Important YouTube Videos” according to Business Insider.   With a video shot on the beaches and boardwalks of Los Angeles, Steve shares some fascinating insights into the production, cast, Garry Gary Beers cameo and the vision behind the first-ever film clip for this fantastic song, and the influence Chris Murphy had. As we close out 2025, a big shout-out to our very important patrons who keep this podcast alive, to all our listeners, our amazing support team behind the scenes and every guest who has given up their time. We thank you so much. Love and peace, and have a great Christmas and New Year's break  We look forward to catching up with some of you soon at our next event on Saturday, 24th January, to celebrate Michael Hutchence's life https://www.inxsaccessallareas.com/new-notable Love Haydn and Bee

    Temple Beth Am Podcasts
    Shabbat Teaching: Vayyigash 5786 Shabbat PM

    Temple Beth Am Podcasts

    Play Episode Listen Later Dec 21, 2025 30:03


    Rabbi-Cantor Hillary Chorny's Shabbat Teaching at Temple Beth Am, Los Angeles, December 20, 2025. (Youtube/Zoom)

    Nerdtropolis
    DAVID KRUMHOLTZ & CALEB ALEXANDER SMITHL: Forelock

    Nerdtropolis

    Play Episode Listen Later Dec 21, 2025 14:21


    David Krumholtz and Caleb Alexander Smith join Nerdtropolis Mayor Sean Tajipour on Reel Insights to dive into Forelock — the darkly funny, character-driven LA story that blends crime, chaos, and an unlikely friendship between two men who should never have crossed paths.Caleb breaks down how much of the film's wild world is pulled straight from real-life Los Angeles, from street-level absurdities to the surreal experience of constantly being mistaken for a certain superhero. He opens up about writing, directing, and starring in the film, sharing what it took to build Caiden's wide-eyed innocence, survive a brutally unforgiving spandex suit, and guide a story that explores male friendship, identity, and the madness hiding beneath the city's glossy surface.David talks about stepping into Randy, the sharp-tongued con artist whose humanity sneaks up on audiences. He reflects on finding the character's emotional core, crafting some of the film's biggest laugh lines on the fly, and discovering the unexpected chemistry that formed the heart of the movie. He also teases his upcoming role in Supergirl: Woman of Tomorrow and how the project stays true to the graphic novel fans love.Together, the duo revisit their first meeting, break down the odd-couple energy that shaped their performances, and talk about the challenges — and joys — of making an indie film with grit, humor, and a beating heart.Visit Nerdtropolis.comhttps://www.Facebook.com/nerdtropolishttps://Instagram.com/nerdtropolishttps://Twitter.com/nerdtropolis

    Justin Bieber - Audio Biography
    Justin Bieber's Holiday Moves: LA Sightings, Skylrk Sneakers, and Coachella 2025 Rumors

    Justin Bieber - Audio Biography

    Play Episode Listen Later Dec 21, 2025 3:19 Transcription Available


    Justin Bieber BioSnap a weekly updated Biography.This is Biosnap AI. In the past few days Justin Bieber has quietly mixed business moves, holiday couple sightings, and renewed speculation about his next career era, creating a low key but telling chapter in his biography.Entertainment outlets including IMDb news and People magazine style affiliates report that Justin and Hailey Bieber have been photographed several times around Los Angeles on holiday outings, from a West Hollywood lunch date to a festive party in Brentwood where they were joined by Kendall Jenner. These public appearances matter mainly because they counter months of recurring tabloid divorce chatter; the images show the couple coordinated, affectionate, and firmly presenting a united front in the most photographed city in the world.Fashion and lifestyle coverage, including AOLs celebrity style desk, has highlighted the pair's contrasting but complementary holiday looks during a recent Los Angeles night out, framing them as a continuing power couple whose streetwear choices still set trends and feed social media mood boards. While fan accounts on Instagram and X have amplified every candid clip, that secondary chatter is derivative and not independently verifiable beyond the reposted paparazzi shots.On the business front, trade outlet SGI Europe reports that Bieber's Skylrk label has just launched Earth Bender, a 3D printed sneaker positioned as a tech driven, sustainability leaning footwear play. That release is arguably the most biographically significant development of the week: it extends his shift from pure pop star to long term brand builder, and places him in the increasingly crowded celebrity sneaker and athleisure space with a product tied to manufacturing innovation rather than just a logo.A year end culture roundup by newsletter writer Trung Phan cites Justin in a widely shared tweet of the year segment, underscoring how his name still functions as instant attention currency in the broader online conversation, even when he is relatively quiet musically.Meanwhile, longer horizon career reporting from outlets like Wikipedia summaries and festival deep dives continues to recycle and update the strong but still unconfirmed rumor that he is in talks to headline Coachella 2025. Those Coachella headlines remain speculative for now; until Goldenvoice or Bieber's camp makes a formal announcement, the story sits in the high potential but not yet verified column of his evolving 2025 narrative.Get the best deals https://amzn.to/3ODvOtaThis content was created in partnership and with the help of Artificial Intelligence AI

    Attorney Dennis Block -Landlord Tenant Podcasts
    LA Made It Impossible To Evict Tenants

    Attorney Dennis Block -Landlord Tenant Podcasts

    Play Episode Listen Later Dec 21, 2025 50:23


    The City of Los Angeles has shifted the legal landscape, creating a system where the burden of legal knowledge rests entirely on the landlord. In this video, we break down how the current legal framework in LA has become a one-sided battleground. Tenants are no longer expected to know their rights; instead, landlords are required to "spoon-feed" every regulation to their tenants just to enforce basic contract rights like collecting rent. We explore the reality of the Tenant Anti-Harassment Ordinance and the lack of reciprocal protections for landlords facing abuse. With the city providing free legal representation to tenants, many property owners are finding themselves forced to subsidize rent-free living. We also dive into how any minor violation of Los Angeles Housing Department (LAHD) ordinances can now be used as a complete defense against an Unlawful Detainer action. To help you navigate this complex environment, we cover the essential compliance steps every LA landlord must follow to protect their property rights: Registering your unit correctly, paying fees, and obtaining your Registration Certificate to avoid losing nuisance cases. The mandatory notices that must be posted, on your property. Handling interest on security deposits and using the interest calculator. Understanding Fair Market Value for both LA City and County. The critical requirement of including the RTC with your 3-Day Notice. The mandatory process of uploading notices to the LAHD. Stay informed on how to protect your investment in a city that has made the eviction process nearly impossible for those who don't follow every single rule to the letter.

    Pod-Crashing
    Pod Crashing Episode 424 With Mindy Rickles From The Podcast Mindy Ed And Don Rickles

    Pod-Crashing

    Play Episode Listen Later Dec 21, 2025 10:04 Transcription Available


    Pod Crashing episode 424 with Mindy Rickles host of the podcast Mindy Ed and Don Rickles. Mindy Rickles and Ed Mann, daughter and son-in-law of comedy icon Don Rickles, will host a weekly podcast featuring a chat between the long-time radio host and standup comic, and commentary on clips of Don, with perspective on what Ed, and particularly Mindy was doing at the time of the original broadcast, what was happening with Don's career, and what he and Mindy's mom Barbara and her late, Emmy Award winning brother Larry were up to then. Season one of Mindy, Ed and Don Rickles will highlight the Jimmy Kimmel Live! appearances as well as never before heard clips of his live shows, as well as stories of Don's career and family life that have yet to be told. Don's audience encompassed one of the widest demographics of any comic, and his appearances with Jimmy helped ensure that exposure to a younger crowd of comedy fans. He sold out shows until his passing in 2017, never stopped working and never lost a step. All of his fans are invited to enjoy these special podcasts. Ed Mann was a radio host in Los Angeles for 19 years and was founder of Premiere Radio Networks, now the largest radio syndicator in the country. Mindy was a standup comic for 10 years and toured the country with her act, opening for the likes of Tim Allen, the late Bob Saget, and others. Wynnefield Productions is podcast producer having wrapped up 117 episodic recaps of the Brady Bunch hosted by The Real Brady Bros, Christopher Knight and Barry Williams, and continues with Q&As, interviews and other exclusive material. 

    Rare Disease Discussions
    Chapter 7: Ongoing Gene Therapies in Lysosomal Disorders

    Rare Disease Discussions

    Play Episode Listen Later Dec 21, 2025 8:39


    Nicola Longo MD, PhDProfessor and Vice Chair of Human Genetics,Allen and Charlotte Ginsburg Chair in Precision Genomic Medicine,Division of Clinical Genetics, Department of Human Genetics,University of California at Los Angeles (UCLA), Los Angeles, CA, USAMark Roberts, MDProfessor and Consultant Neurologist,University of Manchester, Manchester, UKResearch Lead for Adult Metabolic Medicine at Salford Care Organisation, Manchester, UKDrs. Longo and Roberts discussed the current status of gene therapies in rare neuromuscular disorders in this eight-part podcast series. This is derived from the symposium that was presented at World Symposium 2025 in San Diego, California on February 4th through 7th, 2025, and is intended for healthcare professionals only. This podcast includes information about investigational compounds that do not yet have a regulatory approval or authorization for a specific indication. The safety and efficacy of the agents under investigation have not been established and contents of this podcast shall not be used in any manner to directly or indirectly promote or sell the product for unapproved uses. The views, thoughts, and opinions expressed in this presentation belong solely to the author and are subject to change without notice. The contents of this presentation do not constitute an endorsement of any product or indication by Astellas. In this part, Dr. Longo will discuss ongoing gene therapies in lysosomal disorders.Nicola Longo MD, PhDI'm going to present to discuss some example of ongoing gene therapy for lysosomal disorder. There are gene therapy in development for both Fabry disease and some of this involve ex vivo gene therapy, many others involve systemic administration with an AAV, Gaucher disease type 1 that affect the periphery, and Gaucher disease type 2, where the replacement should occur within the central nervous system because this condition affects the brain. There is already one approved gene therapy for lysosomal disorder, which is for the early onset metachromatic leukodystrophy. This has been approved both in Europe and now even in the United States, which consists of ex vivo gene therapy with the administration of an extra gene that restore the function of the defective enzyme. Now there are many others that are ongoing for the same indication. There are gene therapy programs for GM1 and GM2 gangliosidosis, and at least one for Krabbe disease. It is important to know that some of these condition are actually included in the recommended uniform screening panel. Basically, we would have access to patients in a timely manner for some of these conditions. Then there are several gene therapy under development for the mucopolysaccharidoses, including MPS-IH, MPS-II, MPS-IIIA and MPS-IV.There are different type of lysosomal disorders, the one caused by mutation, integral membrane protein, not enzyme within the lysosome, but protein that are present on the membrane of the lysosome. This gene therapy that have been tested, it is for cystinosis, that it is caused by a defective lysosomal and for Danon disease, which is caused by a deficiency of an integral membrane part. Finally, one lysosomal disorder, which obviously seems a metabolic condition, but it is really not, is glycogen storage disease type 2 or Pompe disease, in which there is the intralysosomal accumulation of glycogen. There are several ongoing clinical trials to try to correct the problem in this condition.Now, I'm going to discuss some of the most advanced program in the lysosomal storage disorder. This include one for Fabry, which is on an accelerated approval pathway with phase 1 and 2 data, one for Gaucher disease type 1. Obviously, I'm going to discuss the one that has been already approved for metachromatic leukodystrophy. There is one for Hunter syndrome, and the difference of the one for Hunter syndrome, it is an example of the direct administration of gene therapy within the central nervous system.Finally, there is one ongoing for glycogen storage disease type 2 or Pompe disease in adult patients. In gene therapy for metachromatic leukodystrophy, it was the first gene therapy approved for lysosomal disorder in human, and this requires harvesting the CD34 cell from affected patient and then introducing the [inaudible 00:04:32] gene back in this cell, and then placing them back inside the patient again. This has been very effective in patients who were treated early, and obviously, the treatment needs to occur before there is irreversible brain damage in this patient.In the next part, Dr. Roberts and Longo will discuss treatment with gene therapies.

    Rare Disease Discussions
    Chapter 6: Gene Replacement Therapy in Lysosomal Disorders

    Rare Disease Discussions

    Play Episode Listen Later Dec 21, 2025 3:38


    Nicola Longo MD, PhDProfessor and Vice Chair of Human Genetics,Allen and Charlotte Ginsburg Chair in Precision Genomic Medicine,Division of Clinical Genetics, Department of Human Genetics,University of California at Los Angeles (UCLA), Los Angeles, CA, USAMark Roberts, MDProfessor and Consultant Neurologist,University of Manchester, Manchester, UKResearch Lead for Adult Metabolic Medicine at Salford Care Organisation, Manchester, UKDrs. Longo and Roberts discussed the current status of gene therapies in rare neuromuscular disorders in this eight part podcast series. This is derived from the symposium that was presented at World Symposium 2025, in San Diego, California, on February 4th through 7th, 2025, and is intended for healthcare professionals only. This podcast includes information about investigational compounds that do not yet have a regulatory approval or authorization for a specific indication. The safety and efficacy of the agents under investigation have not been established, and contents of this podcast shall not be used in any manner to directly or indirectly promote or sell the product for unapproved uses. The views, thoughts and opinions expressed in this presentation belong solely to the author and are subject to change without notice. The contents of this presentation do not constitute an endorsement of any product or indication by Astellas. In this part, Dr. Longo will discuss gene replacement therapy in lysosomal disorders.Nicola Longo MD, PhDLet's go back a second to gene therapy. Gene therapy obviously has the potential of answering many of the questions that we still have open in lysosomal disorder because they could restore the activity of the lysosome pretty much in the whole body, or at least in multiple tissues. As you have seen, gene therapy can be done ex vivo where we take cells from the affected patient, we correct the gene, or we put an extra gene that it is functional. Then we put them back by doing a bone marrow transplant, basically creating space for the cells that have been genetically modified to correct the lysosomal defect. The biggest approach this is done usually by lentiviruses that they integrate inside the genome.

    Rare Disease Discussions
    Chapter 3: Immune Responses and Other Safety Concerns Related to Gene Therapies

    Rare Disease Discussions

    Play Episode Listen Later Dec 21, 2025 4:50


    Nicola Longo MD, PhD, and Mark Roberts, MDNicola Longo MD, PhDProfessor and Vice Chair of Human Genetics,Allen and Charlotte Ginsburg Chair in Precision Genomic Medicine,Division of Clinical Genetics, Department of Human Genetics,University of California at Los Angeles (UCLA), Los Angeles, CA, USAMark Roberts, MDProfesor and Consultant Neurologist,University of Manchester, Manchester, UKResearch Lead for Adult Metabolic Medicine at Salford Care Organisation, Manchester, UKDrs. Longo and Roberts discuss the current status of gene therapies in rare neuromuscular disorders in this 8-part podcast series. This is derived from the symposium that was presented at World Symposium 2025 in San Diego, California on February 4th-7th 2025 and is intended for healthcare professionals only.This podcast includes information about investigational compounds that do not yet have a regulatory approval or authorization for a specific indication. The safety and efficacy of the agents under investigation have not been established and contents of this podcast shall not be used in any manner to directly or indirectly promote or sell the product for unapproved uses.The views, thoughts, and opinions expressed in this presentation belong solely to the author and are subject to change without notice. The contents of this presentation do not constitute an endorsement of any product or indication by Astellas. In this part, Dr. Roberts will discuss immune responses and other safety concerns related to gene therapies.Mark Roberts, MDUndoubtedly, the immune system is a major issue in these patients. It would be fantastic if we could immunotolerize our patients and indeed prevent the rejection of the therapy. We've talked about the fact that these are viral vectors and of course there may be high seroprevalence of antibodies to these viral vectors, and it's very important in the pre-screening of patients who might be eligible to understand that at the beginning. These of course can have developed over the years and of course can be part of immunological memory and therefore extremely difficult and probably impractical to actually shift.On giving the treatment though as I think we're all aware there is this problem of the innate immunity and potential therefore for acute toxicities and then a learned or adaptive response with cytotoxic T cells and antibodies which may of course become high tighter neutralizing antibodies and potentially antibodies not only against the viral vector, even the functional protein, even the transgene are all theoretical possibilities with time. The capsid, the transgene, and even the protein product can all potentially induce an immunological event. Of course, all of these would lead to both potential patient changes and then a lack of efficacy of the treatment.Indeed, there have been some serious and indeed fatal problems in the gene therapy development program as I think we're all aware. Though many of these are thankfully been overcome. Spinal muscular atrophy has a gene therapy which is licensed, but there were early patients who actually had significant problems. A patient of just 6 months of age who developed kidney failure, two other patients who actually developed liver failure.In Duchenne muscular dystrophy, a very common condition, again there were significant issues and crucially in these patients who all have cardiomyopathy, it was heart failure and cardiac arrest that were big concerns and pulmonary edema and this was seen even with a CRISPR-based technology and is perhaps is best known but has been addressed the excellent myotubular myopathy patients, four patients died and crucially quite a long time after the gene therapy emphasizing the need to monitor these patients extremely carefully and these patients died of cholestatic liver failure albeit that they had a degree of liver dysfunction.That's changed our screening of course of patients, we're now all looking in myotubular patients for liver involvement and Rett syndrome as well. Now these immunoprophylaxis treatment regimes to hopefully try and reduce the immunological reaction against the gene are certainly evolving.This is just a summary of some of the other immunosuppressive regimes used in other disorders, for example, spinal muscular atrophy, but Pompe and MPS as examples of LSDs. Certainly these regimes will continue to evolve and are going to be very important in seeking to make sure that these treatments are effective. It reminds me somewhat of what's happened with enzyme replacement therapy that the use of these immunological strategies in infants has revolutionized the utility of those treatments in early patients.In the next part, Dr. Roberts will discuss lessons learned from gene therapy trials.

    Rare Disease Discussions
    Chapter 2: Vectors, Different Strategies, Modes of Administration, and Targets

    Rare Disease Discussions

    Play Episode Listen Later Dec 21, 2025 8:59


    Nicola Longo MD, PhD, and Mark Roberts, MD Nicola Longo MD, PhDProfessor and Vice Chair of Human Genetics,Allen and Charlotte Ginsburg Chair in Precision Genomic Medicine,Division of Clinical Genetics, Department of Human Genetics,University of California at Los Angeles (UCLA), Los Angeles, CA, USAMark Roberts, MDProfesor and Consultant Neurologist,University of Manchester, Manchester, UKResearch Lead for Adult Metabolic Medicine at Salford Care Organisation, Manchester, UKDrs. Longo and Roberts discuss the current status of gene therapies in rare neuromuscular disorders in this eight-part podcast series. This is derived from the symposium that was presented at World Symposium 2025 in San Diego, California on February 4th through 7th, 2025 and is intended for healthcare professionals only. This podcast includes information about investigational compounds that do not yet have a regulatory approval or authorization for a specific indication. The safety and efficacy of the agents under investigation have not been established and contents of this podcast shall not be used in any manner to directly or indirectly promote or sell the product for unapproved uses. The views, thoughts, and opinions expressed in this presentation belong solely to the author and are subject to change without notice.The contents of this presentation do not constitute an endorsement of any product or indication by Astellas. In this part, Dr. Roberts will discuss vectors, different strategies, modes of administration and targets in gene replacement therapies.Mark Roberts, MDNow in the broader sense, gene replacement therapy seeks to actually deliver genetic material directly into the host cell to influence gene expression. In the most simple idea, one of course has a vector, this is most commonly but not exclusively a virus, which can then be given intravenously for example, and can hope to potentially correct the condition within the individual cells using novel transgenes. Suitable candidate conditions for this as examples of genetic conditions are now well understood. And crucially, this applies not only towards some more recessive, but dominant and even accident conditions.Across the piece, one can see for example, mitochondrial problems, spinal muscular atrophy as is well known, X-linked myotubular myopathy, Duchenne muscular dystrophy, a very common condition affecting one in 3000 male individuals, Pompe disease of course, an important focus of the meeting here, but other very common conditions, for example, cystic fibrosis, immunological conditions and perhaps obviously very crucial in early work on gene therapy, hemophilia.Let's now think about the approaches to gene therapy. One can seek to work at the DNA level and gene replacement. In essence, one is trying to put a new transgene through into the nucleus that will ultimately be transcribed and translated and produce the important functional protein that is lost. Gene editing which is a very exciting new technology or CRISPR technology actually seeks to actually modify in vivo the actual mutations that are responsible for the pathogenic production of abnormal proteins and correcting these and actually producing a more normalized protein.But of course there are also RNA approaches where one seeks to actually repair the mRNA transcripts copied from the mutated gene. For example, this may be a novel approach that could be extremely useful in myotonic dystrophy, a multisystem condition. When we talk about the viral vectors, predominantly we're talking about viruses. Those such as adenoviruses and AAV viruses which have the virtue of not integrating into the host genome or at least not in a large amount, and those which deliberately seek to integrate into host genome such as retroviral or lentiviral systems that may be particularly useful for ex vivo systems.There are of course other ways to get genetic payloads into the nucleus, various polymers, nanoparticles and even cell penetrating peptides. Nanoparticles in particular is certainly on the ascendant. That being said, in a recent review of the clinical trials in gene therapy, it was certainly the viral vectors that stood out both in direct gene replacement with lentivirus and AAV, but also actually as delivery systems, for example, for gene editing. An example of what one is seeking to do with AAV, so of course one seeking to remove the native DNA, insert the new transgene directly into the vector and of course keen to make sure that there's a high transmission into the capsid producing a recombinant AAV, which then can be given as a treatment and hopefully produce a therapeutic increase in the functional protein that is deficit in the disorder.In the next part, Dr. Roberts will discuss immune responses and other safety concerns related to gene therapies.

    Rare Disease Discussions
    Chapter 4: Lessons Learnt from Gene Therapy Trials

    Rare Disease Discussions

    Play Episode Listen Later Dec 21, 2025 2:08


    Nicola Longo MD, PhD, and Mark Roberts, MDNicola Longo MD, PhDProfessor and Vice Chair of Human Genetics,Allen and Charlotte Ginsburg Chair in Precision Genomic Medicine,Division of Clinical Genetics, Department of Human Genetics,University of California at Los Angeles (UCLA), Los Angeles, CA, USAMark Roberts, MDProfessor and Consultant Neurologist,University of Manchester, Manchester, UKResearch Lead for Adult Metabolic Medicine at Salford Care Organisation, Manchester, UKDrs.Longo and Roberts discussed the current status of gene therapies in rare neuromuscular disorders in this eight-part podcast series. This is derived from the symposium that was presented at World Symposium 2025 in San Diego, California on February 4th through 7th, 2025 and is intended for healthcare professionals only.This podcast includes information about investigational compounds that do not yet have a regulatory approval or authorization for a specific indication. The safety and efficacy of the agents under investigation have not been established and contents of this podcast shall not be used in any manner to directly or indirectly promote or sell the product for unapproved uses. The views, thoughts, and opinions expressed in this presentation belong solely to the author and are subject to change without notice. The contents of this presentation do not constitute an endorsement of any product or indication by Astellas.In this part, Dr. Roberts will discuss lessons learned from gene therapy trials.Mark Roberts, MDWhen we think about the challenges of actually doing clinical trials with these gene therapies, there's a huge development stage in terms of picking the right viral vector with the right surface receptor. That's a major piece of work. That can often take years. The preclinical work is obviously very important as indeed is understanding the natural history because it's really not practical to do placebo-controlled trials of gene therapies.In contrast to other studies, when we turn to phase 1 and phase 2, you'll notice that the patient numbers are often quite small. One is having to think carefully about surrogate measurements of response. Especially when in phase 3 studies, we may be thinking about withdrawing the existing, for example, enzyme replacement therapy because we believe the gene therapy will then be effective.That's just a few snapshots of where we've come and there's a lot more work to be done.In the next part, Dr. Longo will discuss the current treatment landscape and limitations in lysosomal disorders.

    BeSimply
    BeSimply...Silence Golden. Visioning Clear. {Sol +Luna New Moon 11 + 10}

    BeSimply

    Play Episode Listen Later Dec 21, 2025 95:52


    The dance of water (feminine) and fire (masculine) intensifies: water replenishing, fire clearing impurities, opposites in delicate harmony, drawing us inward to retreat and realign within our solar cycle.This is a passage, not just “one day.” Honor the transition over several days rather than a fixed date. In Australia, the shift into summer spans ~4 days; here in the North, winter's arrival unfolds over ~9 days. Awareness of these shifts supports your inner/outer landscape and reclaims your natural rhythm with place.We're spiraling into mastery of self, serving communities with balance and reciprocation, season by season.May you dance freely with Mother Nature and divine love this winter/summer transition. See what unfolds. Nighttime duration (sunset to sunrise) in Los Angeles, CA (Dec 17–26, 2025, via timeanddate.com):Dec 17–25: 14h 7m Dec 26: 14h 6m Look up your location as inspired. May you enter into the Northern winters with the rhythm of slow waltz and Southern summers with the flow of a spicy salsa or tango. Simply. Listen. Rest in the Void.The New Moon reached full potency on Friday, December 19, 2025, eliminating reference to chrono time. Questions:Are you willing to create more space for silence in you daily life?If yes, where is the most effortless place to do this first? If no, why?What are you prepared to start visioning for the benefit of self and others?Weekly talks are an offering to assist you in diving deeper into a spiritual practice, exploring your inner landscape, and cultivating inner peace.Time Stamps: Dharma 0:00 | Meditation 22:00 | Sound 46:00 | Outro 1:25:00MusicRandom Rab  Up Coming Shows:‘Fields of Floors' by Cadre Scott Sound Suzanne Toro Producer: Dante Marino Production brought to you by OmToro Wellness + MediaMind Training: 8 Limbs Yoga Session: Weekly Writings and Well BeingHumanity + Earth Friendly Goodies:SuperfeastLiving TeaKindSpringFormula FlawlessBalance + Focus Quick LinkOra CacoaBook: SunPlayHoney Bee Hippie

    The Tim Dillon Show
    475 - Rob Reiner, Redacted Files, & The Spirit Of Friendship

    The Tim Dillon Show

    Play Episode Listen Later Dec 20, 2025 88:24


    Tim discusses Erika Kirk's appearance at a TPUSA conference, the state of the conservative movement, the tragic story of Rob Reiner and his son Nick, the Epstein files being ‘released' but heavily redacted, the ridiculous story surrounding the Brown University shooting, and why Miriam Adelson and Donald Trump are a symbol of true friendship.  American Royalty Tour

    The President's Daily Brief
    PDB Situation Report | December 20th, 2025: New Year's Eve Terror Plot Foiled & Gaza Ceasefire Tested

    The President's Daily Brief

    Play Episode Listen Later Dec 20, 2025 59:59


    In this episode of The PDB Situation Report: Federal authorities stop a coordinated New Year's Eve terror plot, arresting multiple suspects accused of planning bombing attacks in and around Los Angeles. Former FBI counterterrorism and counterintelligence operative Eric O'Neill joins us to break down how the plot was disrupted and what it reveals about the threat landscape. The Gaza ceasefire holds for now, even as Israel targets senior Hamas leadership. Ben Cohen from the Foundation for Defense of Democracies joins us to explain what comes next and how long the fragile pause may last. To listen to the show ad-free, become a premium member of The President's Daily Brief by visiting https://PDBPremium.com. Please remember to subscribe if you enjoyed this episode of The President's Daily Brief. YouTube: youtube.com/@presidentsdailybrief True Classic: Upgrade your wardrobe and save on @trueclassic at https://trueclassic.com/PDB#trueclassicpod American Financing: Call American Financing today to find out how customers are saving an avg of $800/mo. NMLS 182334, https://nmlsconsumeraccess.org - APR for rates in the 5s start at 6.196% for well qualified borrowers. Call 866-885-1881 for details about credit costs and terms. Visit https://www.AmericanFinancing.net/PDB Debt Relief Advocates: Learn what debt reduction you may qualify for. Go online and visit https://DRA.com/podcast  Learn more about your ad choices. Visit megaphone.fm/adchoices

    Improve your English conversation, vocabulary, grammar, and speaking with free audio lessons
    Simplified Speech #236 – Previewing the Winter Olympics

    Improve your English conversation, vocabulary, grammar, and speaking with free audio lessons

    Play Episode Listen Later Dec 20, 2025 31:32


    In this Culips episode, Andrew and his friend Luke talk about the Winter Olympics and why they are such a big deal in Canada. They chat about Olympic ice hockey, the return of pro NHL players, and the excitement and controversy around the next Games in Italy. You also hear them share their favorite winter sports, talk about strange Olympic events, and play a fun memory game where they try to name past Winter Olympic host cities. What you'll learn with this episode: How to understand and use common conversation words like “chatter,” “lineup,” “controversy,” and “rivalry” How to follow a natural back-and-forth discussion about sports, history, and culture How English speakers react in the moment with expressions like “holy moly” and “it's escaping me” How to give opinions and make predictions in English This episode is perfect for you if: You want listening practice with real, casual English conversation You want to build your speaking skills for everyday topics like sports, travel, and culture You want to learn useful vocabulary that helps you sound more natural and confident in English conversations The Best Way to Learn with This Episode: Culips members get an interactive transcript, helpful study guide, and ad-free audio for this episode. Take your English to the next level by becoming a Culips member. Become a Culips member now: Click here. Members can access the ad-free version: Click here. Join our Discord community to connect with other learners and get more English practice. Click here to join.  Fact check: Ice Dancing vs. Figure Skating Jumps The Claim: Luke mentions knowing the names of maneuvers like the “triple Lutz” and “triple Salchow” because his mom watched Ice Dancing. The Fact: Those are Figure Skating jumps. In competitive Ice Dancing, athletes are actually forbidden from performing these types of multi-rotation jumps. It is a common mix-up, but the two are separate disciplines! Surfing as a “One-Off” Showcase The Claim: Andrew thought Surfing was a one-time showcase sport for the Summer Olympics, similar to breakdancing. The Fact: Unlike breakdancing (which was only for Paris 2024), Surfing is a permanent Olympic sport. It debuted in Tokyo 2020, appeared in Paris 2024, and is already confirmed for the Los Angeles 2028 Games. The History of Ski Jumping The Claim: Luke suggested that ski jumping started at the Calgary 1988 Olympics with Eddie the Eagle. The Fact: Ski jumping is actually one of the original Winter Olympic sports. It has been in every Winter Games since the very first one in 1924 (Chamonix, France)—64 years before the Calgary Games. When the Games “Staggered” (The 2-Year Gap) The Claim: Andrew and Luke discussed the Games being “staggered” (Summer and Winter in different years) starting after 1988. The Fact: The change actually happened after 1992. Both the Summer and Winter Games were held in 1992 (Albertville and Barcelona). The first time the Winter Olympics were held in their own separate year was Lillehammer 1994. Canada's 2010 Gold Medal Record The Claim: Luke estimated that Canada won about 10 gold medals in Vancouver 2010. The Fact: Canada actually won 14 gold medals in 2010. At the time, this set a world record for the most gold medals ever won by a single country at any Winter Olympics.

    Handel On The Law
    New York Doggo Dependents

    Handel On The Law

    Play Episode Listen Later Dec 20, 2025 27:32 Transcription Available


    Handel on the Law. Marginal Legal Advice.See omnystudio.com/listener for privacy information.

    Handel On The Law
    Why Trump Needs Fentanyl

    Handel On The Law

    Play Episode Listen Later Dec 20, 2025 36:14 Transcription Available


    Handel on the Law. Marginal Legal Advice.See omnystudio.com/listener for privacy information.

    Handel On The Law
    Even Trump's Ballroom is Illegal

    Handel On The Law

    Play Episode Listen Later Dec 20, 2025 31:48 Transcription Available


    Handel on the Law. Marginal Legal Advice.See omnystudio.com/listener for privacy information.

    All The Kings Men
    Phil Danault Trade Reaction (w/ Zach Dooley)

    All The Kings Men

    Play Episode Listen Later Dec 20, 2025 36:51


    Zach Dooley joins host Jesse Cohen to react to the trade of Phil Danault. The pair attended the media availability with GM Ken Holland and comment on Danault's time in LA, the impact of the trade and the comments made by Holland to the media.

    Fish Jelly
    #243 - Being Charlie

    Fish Jelly

    Play Episode Listen Later Dec 20, 2025 94:37


    Gay homosexuals Nick and Joseph review Being Charlie - a 2015 American drama film directed by Rob Reiner and written by Matt Elisofon and Nick Reiner. The film stars Nick Robinson, Common, Cary Elwes, Devon Bostick, Morgan Saylor, Susan Misner, and Ricardo Chavira.Additional topics include:Barack Obama's favorite films of 2025Paul Dano's clapbackJosh Grobin x Jenifer Hudson tourJennifer Lewis on the IMO podcastThe deaths of Rob and Michelle ReinerJoin us on Patreon: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.patreon.com/FishJellyFilmReviews⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Want to send them stuff? Fish Jelly PO Box 461752 Los Angeles, CA 90046Find merch here: https://fishjellyfilmreviews.myspreadshop.com/allVenmo @fishjellyVisit their website at www.fishjellyfilms.comFind their podcast at the following: Anchor: https://anchor.fm/fish-jelly Spotify: https://open.spotify.com/show/388hcJA50qkMsrTfu04peH Apple Podcasts: https://podcasts.apple.com/us/podcast/fish-jelly/id1564138767Find them on Instagram: Nick (@ragingbells) Joseph (@joroyolo) Fish Jelly (@fishjellyfilms)Find them on Letterboxd: https://letterboxd.com/ragingbells/ https://letterboxd.com/joroyolo/Nick and Joseph are both Tomatometer-approved critics at Rotten Tomatoes: https://www.rottentomatoes.com/critics/nicholas-bell https://www.rottentomatoes.com/critics/joseph-robinson

    Dave 'Softy' Mahler and Dick Fain
    Softy and Dick 12-19 H3: Sam Darnold's resurgence, Fun with Audio and Lindsey Thiry

    Dave 'Softy' Mahler and Dick Fain

    Play Episode Listen Later Dec 20, 2025 36:12 Transcription Available


    Softy and Hugh discuss just how far Sam Darnold has come in the last two years, while also setting history in the meantime. We have some Fun with Audio! Lindsey Thiry, ESPN Rams Reporter gives Softy the Los Angeles viewpoint on what happened in the game last night.See omnystudio.com/listener for privacy information.

    Home with Dean Sharp
    @HomeWithDeanSharp - All Calls Saturday!!! | Hour 2

    Home with Dean Sharp

    Play Episode Listen Later Dec 20, 2025 31:19 Transcription Available


    Dean takes all your home design calls, including safe, non-toxic ways to get rid of gophers in the garden, as well as how high your baseboards should be in your house. Dean is your sherpa up the mountain of home design!!!See omnystudio.com/listener for privacy information.

    Home with Dean Sharp
    @HomeWithDeanSharp - All Calls Saturday! | Hour 1

    Home with Dean Sharp

    Play Episode Listen Later Dec 20, 2025 30:09 Transcription Available


    Dean answers your home design calls, including how to shake off the fear of doing what's best after disaster strikes your home. Also, can you properly build an indoor space for an outdoor hot tub?? Who knows??? Dean knows. See omnystudio.com/listener for privacy information.

    Political Breakdown
    The Political Year in Retrospect

    Political Breakdown

    Play Episode Listen Later Dec 20, 2025 31:24


    This year in politics, President Donald Trump deployed National Guard troops and Marines to Los Angeles, Oakland and San Francisco received new mayors and a redistricting battle reshaped the state's congressional map. Scott and Marisa are joined by the San Francisco Chronicle's senior political writer Joe Garofoli to analyze the year's top political stories. Plus, they look ahead to 2026, when the race of governor of California heats up and competitive midterm elections will determine control of the U.S. House of Representatives.  Check out Political Breakdown's weekly newsletter, delivered straight to your inbox. Learn more about your ad choices. Visit megaphone.fm/adchoices

    The No Proscenium Podcast
    Hanging Out At The 20-Sided Tavern

    The No Proscenium Podcast

    Play Episode Listen Later Dec 20, 2025 40:59


    This week, a visit to Dungeons & Dragons The 20-Sided Tavern in Los Angeles – where the show is wrapping its current stand this weekend before heading off to Scottsdale, Arizona and Dallas, Texas.We sit down with Alex Stompoly, one of the Tavernkeepers of the Tavern to talk about the unique role he plays in the production which is part MC, part rules lawyer, and carries with it some creative heft of its own.SHOW NOTESDungeons & Dragons The 20-Sided TavernAlex StompolyNo ProsceniumEverything Immersive Hosted on Acast. See acast.com/privacy for more information.

    Mission Matters Podcast with Adam Torres
    Alan Bagh on AFM, Indie Film Momentum, and Building Bagh Films

    Mission Matters Podcast with Adam Torres

    Play Episode Listen Later Dec 20, 2025 9:36


    In this episode of Mission Matters, ⁠⁠Adam Torres⁠⁠ interviews ⁠⁠Alan Bagh⁠⁠, CEO, Producer, Writer & Actor at Bagh Films, about his first American Film Market experience and what it takes to keep moving forward in independent film. Alan discusses pitching feature projects and pilots to distributors and sales agents, staying resilient through industry ups and downs, and his mission to create films that entertain, inspire, and connect with audiences. About ⁠⁠Alan Bagh⁠⁠ Alan Bagh (born May 30, 1985) is an American actor. He is best known for playing the character "Rod" in the horror film Birdemic: Shock and Terror, Birdemic 2: The Resurrection, and Birdemic 3: Sea Eagle. He currently resides in Los Angeles, CA. Follow Adam on Instagram at ⁠⁠https://www.instagram.com/askadamtorres/⁠⁠ for up to date information on book releases and tour schedule. Apply to be a guest on our podcast: ⁠⁠https://missionmatters.lpages.co/podcastguest/⁠⁠ Visit our website: ⁠⁠https://missionmatters.com/⁠⁠ More FREE content from Mission Matters here: ⁠⁠https://linktr.ee/missionmattersmedia⁠⁠ Learn more about your ad choices. Visit podcastchoices.com/adchoices

    Health Youniversity with Dr. Susan Fox
    Fitness for Fertility with Arielle Creager

    Health Youniversity with Dr. Susan Fox

    Play Episode Listen Later Dec 20, 2025 35:24


    Let's talk about” functional fertility fitness” —physical and nutritional.Dr. Susan chats with Arielle Creager, a Los Angeles-based personal trainer, certified nutritionist specialist candidate, and Nike LA trainer, who specializes in empowering pregnant and postpartum mothers through functional fitness and holistic nutrition.Arielle's  personal health journey—overcoming chronic lung congestion through dietary changes when doctors couldn't find answers—sparked her passion for functional medicine and helping women optimize their bodies for conception, pregnancy, and for the rest of their lives.Discover the essential movement patterns every woman should master before pregnancy, which lab tests to request from your doctor when trying to conceive, and why an anti-inflammatory diet is the foundation for fertility success. Arielle shares her own unexpected pregnancy journey, including a diagnosis of cervical insufficiency at 20 weeks that led to emergency cerclage surgery and her son's premature birth at 27 weeks.Learn why strength training—especially core, pelvic floor, and glutes—can make all the difference in pregnancy outcomes, how to properly test for diastasis recti postpartum, and the overlooked connection between chronic dehydration and low energy.This episode is essential for women preparing their bodies for conception, anyone navigating pregnancy complications, postpartum mothers rebuilding their strength, and healthcare providers who want to support holistic perinatal wellness.Website: https://www.empwrwellness.net/about-empwr/ 

    Il Mondo
    Oggi sul mondo Cultura: il nuovo Avatar, Gastone Novelli a Venezia, un libro per ragazzi, l'inferno di Roger Ballen

    Il Mondo

    Play Episode Listen Later Dec 20, 2025 3:37


    Avatar - Fuoco e cenere è il terzo episodio della saga di fantascienza ambientalista creata da James Cameron che, per questo film, ha per scelta evitato qualunque ricorso all'IA. Il museo di Ca' Pesaro a Venezia dedica una retrospettiva al lavoro e all'impegno politico di Gastone Novelli, maestro dell'informale italiano. Billy delle nuvole è un libro per bambini e bambine che mescola avventura e divulgazione scientifica. Il fotografo e artista statunitense Roger Ballen ha illustrato l'Inferno di Dante Alighieri. È la prima volta che un fotografo si misura con la Divina commedia. CONLucia Magi, giornalista che vive a Los Angeles e collabora con InternazionaleLeonardo Merlini, giornalista di Aska news che collabora con InternazionaleAlberto Emiletti, giornalista e redattore di Internazionale KidsDidi Bozzini, curatore e critico d'arteAvatar - Fuoco e cenere: https://www.youtube.com/watch?v=uVQFHlPzNPoGastone Novelli: https://www.youtube.com/watch?v=68SqTBfR3yABilly delle nuvole: https://www.youtube.com/watch?v=GSy6JlnMTCQInferno: https://www.youtube.com/watch?v=6gayexCp6GoCi piacerebbe sapere cosa pensi di questo episodio. Scrivici a podcast@internazionale.it Se ascolti questo podcast e ti piace, abbonati a Internazionale. È un modo concreto per sostenerci e per aiutarci a garantire ogni giorno un'informazione di qualità. Vai su internazionale.it/abbonatiConsulenza editoriale di Chiara NielsenProduzione di Claudio Balboni e Vincenzo De SimoneMusiche di Tommaso Colliva e Raffaele ScognaDirezione creativa di Jonathan Zenti

    Temple Beth Am Podcasts
    Shabbat Sermon: “Many Dreams, One Dream”

    Temple Beth Am Podcasts

    Play Episode Listen Later Dec 20, 2025 15:56


    Rabbi Matt Shapiro's Shabbat Sermon at Temple Beth Am, Los Angeles, December 20, 2025. (Youtube) Special Guest: Rabbi Matt Shapiro.

    Dopey: On the Dark Comedy of Drug Addiction
    Dopey 562: Alec Baldwin! Cocaine Overdose! Overcoming Suicidal Depression! Nick Reiner's Final Dopey Recording! Happy Holidays?

    Dopey: On the Dark Comedy of Drug Addiction

    Play Episode Listen Later Dec 19, 2025 121:25


    www.patreon.com/dopeypodcast  listen without ads!This week on Dopey! A heavy, emotional holiday episode of Dopey that moves between chaos, grief, recovery, dark humor, and connection. Dave opens with a raw, chaotic song about cocaine, crack, and wanting relief, then sets the tone for a brutal week shaped by multiple tragedies — including the shocking deaths of Rob and Michelle Reiner and the arrest of their son Nick Reiner, a former Dopey guest.The episode includes sponsor reads, listener Christmas messages, and reflections on sticking together in recovery when the world feels overwhelming. Dave reads Spotify comments, emails, and shares messages from the Dopey Nation, emphasizing connection, gratitude, and community during the holidays.The centerpiece is a long, candid interview with Alec Baldwin, recorded just before Thanksgiving. Alec discusses growing up on Long Island, early drinking and cocaine use, working in New York television, moving to Los Angeles, fame, excess, driving intoxicated, overdosing in a hotel room in Oregon, and ultimately getting sober in 1985. He describes how AA became his entire social world, how spirituality helped keep him sober, and how his faith and family carried him through later life crises — including public scrutiny, divorce, legal battles, and depression. Alec speaks openly about wanting to “just not kill myself tomorrow” during his darkest moments and how sobriety principles guided him through.After the interview, Dave plays more holiday messages from the Dopey Nation and then has a long, emotional phone call with his father, Alan Manheim. They process the Nick Reiner tragedy, public backlash, antisemitic comments, criticism of old Dopey clips resurfacing online, and the strange irony of Dopey being thrust into the media spotlight through tragedy. They discuss parenting addicts, mental illness, fame, synchronicity, and how Dopey interviews became central to news coverage. The episode closes with reflections on resilience, staying connected, asking for help, and honoring Chris, followed by Dave playing his song “Good So Bad.”SEO / SEARCHABLE KEYWORDS (CUT & PASTE)  Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

    You Better You Bet
    Full Show - 12.18.2025 - TNF Bets, NFL Week 16

    You Better You Bet

    Play Episode Listen Later Dec 19, 2025 178:14


    Nick Kostos & Femi Abebefe are LIVE! The guys break down how they're betting tonight's Thursday Night Football game between Los Angeles and Seattle. Plus Nick & Femi hit on the projected NFL Playoff Bracket and give out their bets for tonight. Joey Knish and Rob Pizzola join the show.

    You Better You Bet
    Hour 1 - Femi's NFL Awards Breakdown

    You Better You Bet

    Play Episode Listen Later Dec 19, 2025 44:32


    Femi Abebefe is LIVE on this Football Thursday! Femi Abebefe previews tonight's Thursday Night Football between Los Angeles and Seattle. Plus, Femi hits on today's headlines and breaks down NFL Coach of the Year.

    Stand to Reason Weekly Podcast
    Are All Values and Duties Subjective Since They Only Exist in Minds?

    Stand to Reason Weekly Podcast

    Play Episode Listen Later Dec 19, 2025 58:00


    Greg talks to callers about whether all values and duties are inherently subjective, whether Paul is making the same point in Ephesians 2:7 and Romans 9:23, biblical justification for Christian Zionism, and how God can be good if he doesn't save everyone he created.   Topics: How would you respond to the claim that values and duties are inherently subjective since concepts exist only in minds? (04:00) Is Paul making the same point in Ephesians 2:7 and Romans 9:23? (16:00) What is the biblical justification for Christian Zionism? (25:00) How can I make a compelling case for the character of God in answer to the question of why he doesn't save everyone he's created even though he's capable of doing so? (50:00) Mentioned on the Show:  Reality Student Apologetics Conference – February 20–21 in Dallas, TX; March 13–14 in Philadelphia, PA; April 24–25 in Los Angeles, CA Donate to Stand to Reason “Morality based on God is just another form of relativism.” – Part of November's Solid Ground Conversations with an Atheist The Bible: Fast Forward – DVD (Also available as a digital download or audio) Related Links: Why Did God Create People if He Knew So Many Would Go to Hell? by Amy Hall