Podcasts about ucsd school

Dr. Shouhed is a nationally renowned, board-certifiedminimally invasive weight loss surgeon with expertise in Robotic Bariatric, Gastrointestinal, and Complex General Surgery. He was born and raised in Los Angeles, California, and graduated summa cum laude from UCLA with adegree in Human Physiology.  Dr. Shouhed earned early recognition, a Phi Beta Kappa induction, and a near-perfect MCAT score, which secured him a placeat UCSD School of Medicine with the highest merit-based scholarship. Dr. Shouhed completed his general surgery residency training at Cedars Sinai (#2Hospital in the country), where he graduated as Administrative Chief Resident.  He completed his fellowship at Mount Sinai Hospital in New York, the first fellowship in the country, where he focused on minimally invasive bariatric, foregut and complex general surgery. Dr. Shouhed is also Medical Director of the Bariatric Surgery and Metabolic Weight Loss Center, Providence Saint John's Hospital.  Our focus today is really about the vascularabdominal syndromes that we can see so prevalent in connective tissue disorders & complex conditions. Please get us started with a description of the anatomy of the abdomen, including the GI organs, but also the ligaments &connective tissue that holds these organs in place and the vasculature that feeds them oxygen & carries away metabolic wastes.     Now, let's get into the syndromes that we wantto focus on today & we're going from the top down because that's how they might be unlocked, meaning closest to the heart to the most distant to the heart and in the pelvis, that's from chest to pelvis direction.     a. MALS: median arcuate ligament syndromeb. SMAS: superior mesenteric artery syndrome(duodenal comp) (meat?)c. Nutcracker: renal vein compressiond. May Thurner: iliac vein compressione. Pelvic congestion syndromes including pelvicvenous insufficiency, vaginal/ labial varices  For each we talk about: a. Symptomsb. Evaluation c. Treatment: ancillary tx? Visceral manipulation? What would a patient look for in a provider? Whois doing this care? How easy/ common are folks doing these treatments? Howoften can or do treatments go wrong? We end with discussing: where is research going with this? To find out more about our clinic (and request a call back): ⁠https://www.neurovedahealth.com/⁠- Phone: 206-379-1213- Email Reception@neurovedahealth.com

Esta mañana en #Noticias7AM entrevistamos Dra. Mónica Xommer Kondo, Especialista.   Tema: Realizan en TJ Masterclass “Imágenes avanzadas y terapéutica quirúrgica en la endometriosis”.   - Este jueves 18 y viernes 19, en Tijuana con renombrados médicos de talla internacional – de la CdMx, Nueva York, Italia, y Brasil por mencionar a alguno, quienes hablarán específicamente sobre turismo médico, ya que la de los pacientes es lo que se considera turismo de salud.   - Esta Masterclass se imparte en la Academia de Innovación Quirúrgica de Hospitales Cyntar y con el auspicio de UCSD School of Medicine, Center for the Future of Surgery, la UABC, el Instituto de Medicina Metabólica de Tijuana y el IBC de la Universidad de Oxford.   #Uniradioinforma

Dr. Ken Druck is one of the world's leading experts on grief and resilience. Since losing his own daughter in a tragic accident, and working with families after 9/11, Sandy Hook, and Columbine, he has dedicated his life to providing roadmaps for getting through life's most daunting and difficult times and navigating its daily ups and downs. Dr. Ken is a bestselling author of several books, including his most recent, How We Go On: Self-Compassion, Courage, and Gratitude on the Path Forward (2023). He is a recipient of the prestigious Distinguished Contribution to Psychology award, a lecturer at UCSD School of Medicine, and a noted speaker for conferences, special gatherings, and global organizations.Become a supporter of this podcast: https://www.spreaker.com/podcast/mission-evolution-with-gwilda-wiyaka--2888020/support.

Near-death experience guest 839 is Paul Sugar who had a NDE experience after rolling his car. Paul is a Certified MBSR/MBCT instructor and mentor for certification candidates at Center for Mindfulness, UCSD School of Medicine. He delivers holistic health programs with an emphasis on the practice of mindfulness: stress reduction, performance enhancement, critical thinking and attention skills; Promotes motivation to achieve physical, mental and emotional fitness; Provides instruction and CE accreditation for health care providers. Paul's YouTube Channel https://www.youtube.com/@stressbeaters Paul's Website https://www.stressbeaters.com/ --- Send in a voice message: https://podcasters.spotify.com/pod/show/jeffrey-s-reynolds/message Support this podcast: https://podcasters.spotify.com/pod/show/jeffrey-s-reynolds/support

Join Kristen Fogle for this week's episode as she is joined by Georgia Sadler, Professor of Surgery at the UCSD School of Medicine.Thank you for listening and joining the SheEO Lead-In community!

On this episode of Mind Body Peak Performance, our host, Nick Urban, and guest Caitlin Thompson delve into the transformative effects of a unique Amazonian medicine called Kambo.Tune in to explore Kambo's physiological and long-term benefits, differentiation from classic psychedelics, the significance of the so-called medicinal integration process, safe administration, and the potential for a paradigm shift in medical research.Meet our guestCaitlin Thompson is a seasoned international Kambo practitioner having served over 1,300 clients with a specialty in Lyme disease, autoimmune conditions, and other chronic illnesses. Caitlin came to her specialty through conquering her battle with Lyme disease and chronic illness symptoms. She is proudly in remission with consistent vibrant health.Caitlin is formally educated as a neurobiologist and is a research associate at UCSD School of Medicine. She operates as an independent scientific researcher with her previous studies focusing on psychedelics and their potential for treating autoimmune conditions and the prebiotic effects of herbs on the human microbiome. She is currently pioneering some of the first human studies on Kambo.Caitlin has been featured in over 80+ podcasts, interviews, conferences, speaking engagements, and even international television appearances as a leading Kambo expert. Her set of skills makes her uniquely qualified to integrate the art and magic of Kambo with the scientific world.Thank you to our partners Outliyr Peak Performance Shop: get exclusive discounts on cutting-edge health, wellness, & performance gear Ultimate Holiday Specials: a roundup article of all the best current deals on technology, supplements, systems and more Gain mental clarity, energy, motivation, and focus with the FREE Outliyr Nootropics Mini-CourseKey takeaways Kambo is not a psychedelic but can be used to physically and emotionally address trauma and chronic illnesses How Kambo can produce anti-inflammatory and anti-microbial effects How to use integration from these experiences for personal growth and healing Always prioritize safety. Find and work with experienced practitionersLinks Watch it on YouTube: https://youtu.be/Xk6Qn9vqvc8 Full episode show notes: mindbodypeak.com/136Connect with Nick on social media Instagram Twitter YouTube LinkedInEasy ways to support Subscribe Leave an Apple Podcast review Suggest a guestDo you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you!Be an Outliyr,Nick

As 2024 comes closer and closer, I will be rolling out Kambo weight loss programs as well as kambo addiction and kambo autoimmune programs   Kambo helps support me and others with all that, and this week and next, I will be highlighting education and research that speaks to all this I shed 40 lbs, got my autoimmune disease numbers DOWN and also regained my confidence/trust in myself, returning back to my higher truth and SO much more I will be speaking with @medicinefrogkambo  this Wednesday and sharing her scientific research and her story of this amazing Amazonian medicine    Next week is our free masterclass with an expert in health science and sharing her own autoimmune journey in @kambo_sombo    If you know someone struggling with weight issues, depression, addiction, or autoimmune  health issues, please share with them, especially if they were like me, and tried everything else out there   Caitlin Thompson is a seasoned international Kambo practitioner having served over 1,300 clients with a specialty in Lyme disease, autoimmune conditions and other chronic illnesses. Caitlin came to her specialty through conquering her own personal battle with Lyme disease and chronic illness symptoms. She is proudly in remission with consistent vibrant health.    Caitlin is formally educated as a neurobiologist and is a research associate at UCSD School of Medicine. She operates as an independent scientific researcher with her previous studies  focusing on psychedelics and their potential for treating autoimmune conditions and the prebiotic effects of herbs on the human microbiome. She is currently pioneering some of the first human studies on Kambo.   Caitlin has been featured in over 80+ podcasts, interviews, conferences, speaking engagements and even international television appearances as a leading Kambo expert. Her set of skills makes her uniquely qualified to integrate the art and magic of Kambo with the scientific world. Here is Caitlin's website:   https://kambospecialist.com/   https://medicinefrogkambo.com/   You can also follow her in IG: https://www.instagram.com/medicinefrogkambo/   Register for Magdalena's kambo masterclass here: https://kambohealing.now.site/home     FIND OUT MORE ABOUT MAGDALENA GRACE HERE: https://linktr.ee/magdalenagrace   JOIN OUR HEALTHY N WEALTHY N WISE MICRODOSING COMMUNITY WITH AYAHUASCA SUBSCRIPTION HERE:   www.microdosingforhealth.com   LEARN ABOUT MICRODOSING FOR YOUR HEALTH/WEALTH/WISDOM JOURNEY https://microdosingforhealth.now.site   Sit with Kambo for weight loss, addiction or autoimmune issues (also for couples therapy) https://kambohealing.now.site/home   WANNA SIGN UP AND BE A PLEDGING PATRON FOR HEALTHY N WEALTHY N WISE? https://patron.podbean.com/loiskoffi   JOIN OUR TELEGRAM CHANNEL FOR MORE INSPIRATION   https://t.me/healthynwealthynwise   JOIN HER FACEBOOK COMMUNITY AT HER PODCAST WEBSITE: www.healthynwealthynwise.com   SUBSCRIBE TO HER YOUTUBE CHANNEL: https://www.youtube.com/loiskofficoffee  

Join us as we embark on a journey through the world of dating, relationships, and the pursuit of happiness. In today's episode, we cover “The 5 Hidden Love Questions" with Dr. Victor Frank, a happiness engineer and behavioral change specialist. His training includes a bachelor's degree from Harvard College, M.D. from the UCSD School of Medicine, and M.Phil. from Cambridge, certifications in clinical hypnotherapy, NLP, and Havening Techniques®. He's developed Creative Repatterning, a proprietary method for establishing new behaviors. He's given 3 TEDx talks and is the creator of the online course "Super Charisma: How to Be a Transformative Speaker", the highest-rated public speaking course on Udemy. The Tao of Dating has sold 100,000+ copies by word of mouth only and was the highest-rated dating book on Amazon for 8 years.In this episode, we cover the following:Why this topic is vital for happinessWhy the Tao of DatingRelationship assets and values matchingASKOR CriteriaThe 5 Hidden QuestionsThe 5 pillars of human thrivingHelpful links:The 5 Hidden Love Questions: Radically Simple Strategies to Date Smarter, Own Your Power, and Flourish (The Tao of Dating) by Dr. Victor FrankThe Tao of DatingMeditation AudiosAnother Look at Whether a Rising Tide Lifts All BoatsTen Arguments for Deleting Your Social Media Accounts Right NowThinking, Fast and SlowThe Third Body by Robert BlyThe Spread of Obesity in a Large Social Network over 32 Years Another Look at Whether a Rising Tide Lifts All Boats Ten Arguments for Deleting Your Social Media Accounts Right Now Hardcover by Jaron Lanier The photon-avalanche effect: review, model and application Hosted on Acast. See acast.com/privacy for more information.

Zenith All Natural Fat Burning Supplement Buy Zenith here Awakendnation.com/integrativematt Extra Zenith information: https://www.youtube.com/watch?v=igEyMcaCZDw https://www.youtube.com/watch?v=FSSZ-USzz3k https://www.youtube.com/watch?v=y9mkWri8TAw   Magnesium Breakthrough Use Code : integrativethoughts10 for 10% OFF https://bioptimizers.com/shop/products/magnesium-breakthrough   Integrative Thoughts Instagram: @integrativematt Website: Integrativethoughts.com   Guest: Caitlin Thompson   Caitlin Thompson is a seasoned international Kambo practitioner having served over 1,600 clients with a specialty in Lyme disease, autoimmune conditions and other chronic illnesses. Caitlin came to her specialty through conquering her own personal battle with Lyme disease and chronic illness symptoms.  Caitlin is formally educated as a neurobiologist and is a research associate at UCSD School of Medicine. She operates as an independent scientific researcher with her previous studies focusing on psychedelics and their potential for treating autoimmune conditions and the prebiotic effects of herbs on the human microbiome. She is currently pioneering some of the first human studies on Kambo. Caitlin has been featured in over 80+ podcasts, interviews, conferences, speaking engagements and even international television appearances as a leading Kambo expert. Her set of skills makes her uniquely qualified to integrate the art and magic of Kambo with the scientific world. Kambo practice website- https://medicinefrogkambo.com Kambo practitioner and specialty training website - https://kambospecialist.com Find a Kambo practitioner - https://kambofinder.com

Dr. Joy Jacobs is a clinical psychologist, assistant clinical professor at UCSD School of Medicine, and published author who provides individual, family, and group therapy for adults, adolescents, and children with eating disorders (including anorexia nervosa, bulimia nervosa, and binge eating disorder), food addiction and weight management concerns. She has trained in multiple treatment modalities, including family-based therapy, dialectical behavioral therapy, cognitive behavioral therapy, and interpersonal psychotherapy. Dr. Jacobs is one of the few officially certified providers of family-based treatment for eating disorders nationwide and internationally. Dr. Jacobs regularly appears on various media outlets, including The Doctors, Fox 5 San Diego, and has been an expert cited in many national publications, including Elle, US News, and World Report, the Today Show, and more, on the issues of eating disorders, body image, food addiction, weight management, and related topics. Joy is the author of a blog sponsored by Psychology Today and Gurze books, titled One More Bite. In this episode: Dr. Jacobs' personal and professional journey How to help clients determine if they are experiencing emotional eating, disordered eating, eating disorder, and food addiction Tools Dr. Jacobs uses to determine treatment plans How Dr. Jacobs works with clients who may be incorrectly self-diagnosing food addiction Volume addiction When self-worth is attached to weight and body size Differences in treatment for different genders Dr. Jacobs' Glow Up with Joy program Signature Question Follow Dr. Jacobs: Glow Up with Joy Program: https://joyshealthybites.com/glowup/ Website: http://www.drjoyjacobs.com Instagram: @drjoyjacobs Facebook: http://www.facebook.com/drjoyjacobs   The content of our show is educational only. It does not supplement or supersede your healthcare provider's professional relationship and direction. Always seek the advice of your physician or other qualified mental health providers with any questions you may have regarding a medical condition, substance use disorder, or mental health concern.

The University of San Diego held its 39th Annual Economic Roundtable to take stock of where the national and local economies may be headed in 2023. Next, the U.S. military is struggling to meet recruitment goals. With fewer young people enlisting, now the Navy is allowing older people to join. Then, new research from the UCSD School of Global Policy and Strategy suggests that salary transparency can lead companies to close their gender wage gaps, but not for the reason you might think. And, while it feels like winter outside, spring training, and the return of Padre baseball, is just a month away. Finally, a young San Diego theater company launches it's first full season with a play about a campus sexual assault.

Having "the talk" as a teenager is a time-honored tradition. Many experience it with their parents, but a visit with a pediatric clinician is an ideal time to ensure that a teenager knows the correct information, has the opportunity to make certain contraceptive choices, and instill the knowledge that the pediatric office is a safe place to come for help. in this episode Dr. Helen Wang, an assistant clinical professor at the University of California San Diego (UCSD) School of Medicine facilitates a discussion about adolescent patients and having “the talk” with her colleagues: Dr. Kanani Titchen, an assistant clinical professor of adolescent and young adult medicine also of the UCSD School of Medicine and Dr. Samantha V. Hill an Adolescent Medicine Physician at the University of Alabama at Birmingham .

Athlete and entrepreneur, Sasha Dingle joins Liz Solomon to discuss her experience learning to live in harmony with her drive to excel. Dingle is a high achiever in many facets of her life. She is the Founder and Director of Mountain Mind Project. She is a qualified Mindfulness-Based Stress Reduction (MBSR) Teacher by the UCSD School of Medicine MBPTI. As a meditation teacher she facilitates mindfulness programs to an international client audience in the areas of leadership development, healthcare, education, and sports mental fitness. Support the show

The brain seeks meaning and patterns. It would be very adaptive to do so in nature, because you need to know how to predict danger and to develop social ties. So our brains are very good at recognizing patterns, but also at creating them, even when they're not there. - Dr. Jay Giedd, Chair of Child Psychiatry at Rady Children's Hospital - San Diego and Director of Child and Adolescent Psychiatry, Professor of Psychiatry at UCSD School of Medicine, and Professor in the Department of Population, Family and Reproductive Health at Johns Hopkins Bloomberg School of Public Health.   Episode 20: Neural Traffic Flow in the Conscious Brain with Dr. Jay Giedd In this lighthearted conversation, Bernard Baars welcomes returning guest, developmental neuropsychiatrist Dr. Jay Giedd, Professor of Psychiatry at UC San Diego School of Medicine. Their discussion touches on the nuances of unconscious and conscious states, the relationship between dreams and waking moments, and what the recent science tells us about different brain specializations.   Talking Points 0:00 – How does consciousness emerge? 8:46  – Ways to study dreams 17:05 – Conscious truth and fantasy 22:57 – Brain connectivity: The street map and the traffic flow 29:19 – Clarifying the concepts   Summary How does consciousness emerge? Jay Giedd shares with Bernie Baars one of the utmost questions on his mind as of late, namely, at what point do we cross the threshold from being unconscious to being conscious?  They examine how sleep studies and improving brain imaging technology can help us understand the nature of consciousness, and Jay considers the notion that emergence of awareness is caused not only by the quantity of brain neurons, but also by the types of connections.  To Sleep, Perchance to Dream The duo discuss dream content, and Jay reflects on his initial training as a Freudian psychoanalyst, part of which included keeping a dream journal. He makes the observation that although the dreaming mind can create a narrative where the laws of physics and biology are defied, our dreams are nonetheless connected to our day-to-day activities. Bernie suggests that one possible hypothesis for this phenomenon is the cortex trying to find meaning, even with random input. Sensory Perception and Conscious Beliefs: True or False? Jay highlights the fact that perception and cognition do not always accurately represent reality. In terms of increasing our chances of survival, it may be more important that our perception and pattern recognition skills actually work, rather than how accurate they are. Jay also emphasizes that over time, the physiology underlying conscious signals might have been strengthened by providing humans the ability to cooperate and better understand one another, thus further increasing our odds of survival. How neural traffic flow is measured and the limitations of our scientific tools. Bernie makes a distinction between the functional and the anatomical connectivity of the brain. Jay reinforces this by explaining how neural traffic flow can be measured. Scientific tools have greatly improved, but there are still many puzzles that are unsolved. In the final moments of their conversation, Jay shares his belief that one day, consciousness will not seem incomprehensible, although he acknowledges that we still have a long way to go. He emphasizes the immense complexity of the developing brain and the emergence of consciousness.   “Good science always raises more questions than answers,” concludes Dr. Giedd. “And consciousness is a great example of that.”    Get a 40% Discount for your copy of Bernie Baars' acclaimed new book On Consciousness: Science & Subjectivity - Updated Works on Global Workspace Theory GO TO: http://shop.thenautiluspress.com APPLY DISCOUNT CODE AT CHECKOUT: "PODCASTVIP"   Bios Dr. Jay Giedd is the Chair of Child Psychiatry at Rady Children's Hospital - San Diego and Director of Child and Adolescent Psychiatry. Dr. Giedd is also a Professor of Psychiatry at UCSD School of Medicine, and Professor in the Department of Population, Family and Reproductive Health at Johns Hopkins Bloomberg School of Public Health.   Dr. Giedd was chief of the Section on Brain Imaging, Child Psychiatry Branch of the National Institute of Mental Health (NIMH). His widely published research and expertise evaluates how the child's brain develops in health and illness, the factors that influence development and how to optimize treatments to take advantage of the child's changing brain. Jay and his award winning work were featured in the PBS 2 part series "Brains on Trial" hosted by Alan Alda.   Bernard Baars is best known as the originator of global workspace theory and global workspace dynamics, a theory of human cognitive architecture, the cortex and consciousness. Bernie is a former Senior Fellow in Theoretical Neurobiology at the Neurosciences Institute in La Jolla, CA, and Editor in Chief of the Society for MindBrain Sciences. He is author of many scientific papers, articles, essays, chapters, and acclaimed books and textbooks.   Bernie is the recipient of the 2019 Hermann von Helmholtz Life Contribution Award by the International Neural Network Society, which recognizes work in perception proven to be paradigm changing and long-lasting.   He teaches science. It keeps him out of trouble.

About Today's GuestCarie Rodgers, Ph.D., ABPP, currently serves as Chief Program Officer at PsychArmor Institute, and is a Clinical Professor of Psychiatry at the UCSD School of Medicine. Prior to joining the team, she was the Associate Director of the Education & Dissemination Unit at the VA Center of Excellence for Stress and Mental Health in San Diego, California.She has served as a National Trainer for the VA's Cognitive Processing Therapy initiative and as a consultant for the National Center for PTSD. She has provided training and consultation to hundreds of mental health providers in the VA and the Department of Defense, as well as in the broader community. Dr. Rodgers was also a Consultant for the VA's national roll-out of Prolonged Exposure Therapy and was the Director of the VA San Diego Military Sexual Trauma Program. She received her Ph.D. in Clinical Psychology in 2000 from the University of Oregon, and completed her internship and postdoctoral training at UCSD and the San Diego VA. A licensed Clinical Psychologist in the state of California, Dr. Rodgers is also Board Certified in Clinical Psychology by the American Board of Professional Psychology.Links Mentioned In This EpisodeDr. Rodgers' Profile on PsychArmorKirkpatrick Training ModelPsychArmor Resource of the WeekThe PsychArmor Resource of the Week is the PsychArmor course, 15 Things Veterans Want You to Know for Healthcare Providers. This course was created to educate Healthcare Providers who care for our military Veterans. PsychArmor asked hundreds of Veterans what they wanted civilians, employers, educators, health care providers, and therapists to know about them, and we share them with you in this course. You can find a link to the here:  https://learn.psycharmor.org/courses/15-things-veterans-for-healthcare-providersThis Episode Sponsored By:This episode is sponsored by PsychArmor, the premier education and learning ecosystem specializing in military culture content. PsychArmor offers an online e-learning laboratory with custom training options for organizations.Contact Us and Join Us on Social Media Email PsychArmorPsychArmor on TwitterPsychArmor on FacebookPsychArmor on YouTubePsychArmor on LinkedInPsychArmor on InstagramTheme MusicOur theme music Don't Kill the Messenger was written and performed by Navy Veteran Jerry Maniscalco, in cooperation with Operation Encore, a non profit committed to supporting singer/songwriter and musicians across the military and Veteran communities.Producer and Host Duane France is a retired Army Noncommissioned Officer, combat veteran, and clinical mental health counselor for service members, veterans, and their families.  You can find more about the work that he is doing at www.veteranmentalhealth.com  

Dr. Jennie and Dr. Sawyer cover the following topics in episode 3 of season 2 KidzDocTalk:-Percentage of eligible children vaccinated-Purpose and goal for Covid vaccines-Each family's risk/benefit analysis-Family interactions when a member is infected-Avoiding exposure, transmission, infection and reinfection-What underlying conditions are being seen in hospitalized children-Current trends, peaks and surges-Children not eligible for the Covid vaccine yet-Overloaded hospitals-Outdoor gatherings/activities without masking but still distanced-Importance of ventilation-The efficiency of social distancing and masks two years into the pandemic-Living with Covid in the future About Dr. Mark Sawyer:Dr. Sawyer is a Professor of Clinical Pediatrics and a Pediatric Infectious Disease specialist at the UCSD School of Medicine and Rady Children's Hospital San Diego.  He is the medical director of the UCSD San Diego Immunization Partnership, a contract with the San Diego County Agency for Health and Human Services to improve immunization delivery in San Diego. He is a past member of the American Academy of Pediatrics Committee on Infectious Diseases, the FDA Vaccines and Related Biological Products Advisory Committee (VRBPAC) and the CDC Advisory Committee on Immunization Practices (ACIP) and is an Associate Editor of the AAP Red Book. Recently he was recalled to VRBPAC to work on the FDA approval of COVID vaccines

Prebiotics and probiotics. Fecal microbiota transplants. Optimizing a diet personalized to you. These microbiome-themed topics are all around us in the media, but microbiome research remains a fairly nascent field of study and wasn't on many people's radars even 10 years ago. UCSD Professor Dr. Jack Gilbert and Institute for Systems Biology (ISB) Assistant Professor Dr. Sean Gibbons came together to tackle this exciting area of research. What have we learned over the past few years? What has gone well, and what could we do better? The two discussed some exciting developments on the horizon and share when they think people might see microbiome-based technologies in their daily lives. Dr. Jack A. Gilbert is a Professor of Microbial Oceanography in the Center for Marine Biotechnology and Biomedicine at Scripps Institute of Oceanography, and holds a joint appointment in the Department of Pediatrics in UCSD School of Medicine. Dr. Gilbert is also cofounder of the Earth Microbiome Project and American Gut Project, has authored more than 350 peer-reviewed publications and book chapters on microbial ecology, and is the founding Editor in Chief of mSystems journal. He has been recognized on Crain's Business Chicago's “40 Under 40 List,” listed as one of the 50 most influential scientists by Business Insider, and was named as one of the “Brilliant Ten” by Popular Scientist. He is the co-author of Dirt is Good, a popular science guide to the microbiome and children's health. Dr. Sean Gibbons is Assistant Professor at ISB. He holds a Ph.D. in biophysical sciences from the University of Chicago; his graduate work focused on using microbial communities as empirical models for testing ecological theory. Gibbons completed his postdoctoral training in Eric Alm's laboratory in the Department of Biological Engineering at MIT, where his work focused on developing techniques to quantify individual-specific eco-evolutionary dynamics within the human gut microbiome. He is particularly interested in learning how organisms in the human gut change and adapt to individual people over their lifespans, and how those changes impact health. Presented by the Institute for Systems Biology and Town Hall Seattle.

Researchers at the UCSD School of Medicine has a new method of calculating canine aging based on your dog's DNA. Listen find out your dog's real age and how help them live their best life longer. CONNECT WITH US https://jackrussellparents.com  FB/IG/TW: @jrtpodcast

Welcome back to True to Your Heart, brought to you by Amarin. Joining Ron Jaworski on the show today are doctors Steve Edelman and Schafer Boeder. They're here to discuss how diabetes can impact your heart health and give expert advice on how those with diabetes can address both. Dr. Edelman is the founder and director of the ‘Taking Control of Your Diabetes' organization, a Professor of Medicine in the Division of Endocrinology - Diabetes & Metabolism at the University of California, San Diego, and the Director of the Diabetes Care Clinic at the VA Medical Center. Dr. Boeder is a Co-Director, Endocrinologist, and Assistant Professor of Medicine at the UCSD School of Medicine and is also an educator for organizations like ‘Taking Control of your Diabetes.' Today they both help discuss little-known side effects of diabetes like cardiovascular disease, lifestyle tips to drastically reduce one's risk for heart disease, diabetes mythbusters, and more!Follow UsTwitter @JawsCEOQBFacebook @jawsceoqbInstagram @jawsceoqbPresented by Amarinhttps://truetoyourheart.com

On this episode, Josh has a very fun, engaging and enlightening conversation with Caitlin Thompson on all things Kambo and other various healing modalities via plant medicine. Caitlin Thompson is a neurobiologist and certified Kambo practitioner, administering unique traditional Amazonian frog medicine rituals throughout the Southwest. Caitlin is also an independent scientific researcher and research associate at UCSD School of Medicine and is currently conducting research on the potential of psychedelic compounds as a novel approach to autoimmune conditions, as well as the first human kambo studies. After conquering her own battle with depression and anxiety, Caitlin set out on a mission to share healing tools and empower other individuals to take their mental wellness into their own hands. During her healing process from Lyme disease, chronic fatigue, PTSD, pain, and a plethora of other typical autoimmune symptoms, she founded her nutritional supplement company, and began practicing Kambo in an effort to make evidence-based magic of lesser known modalities available to those in need. Enjoy the show!! __ http://medicinefrogkambo.com How To Choose a Practitioner: https://medicinefrogkambo.com/how-to-choose-a-kambo-practitioner/ Kambo Frog Medicine - Everything You Need To Know: https://medicinefrogkambo.com/kambo-frog-medicine-everything-you-need-to-know/ __ Full Episode on YouTube: https://youtu.be/uqUUmG7MLV8

Precision medicine is revolutionizing cancer care. Dr. Razelle Kurzrock highlights how personalized treatments improve patient outcomes and quality of life. Plus, it’s enrollment season! Get the information you need for Medicare enrollment in this week’s conversation with Samantha Smith from the Patients Rising Concierge. And as November marks Lung Cancer Awareness Month, Terry and Dr. Bob look at COVID-19’s impact on cancer screenings and late-stage diagnoses. Guest:Razelle Kurzrock, M.D.Chief Medical Advisor and Co-Founder, CureMatchA board-certified medical oncologist and a renowned expert in precision medicine, Dr. Kurzrock is known for developing one of the largest and best known Phase I clinical trial programs in the United States while at MD Anderson Cancer Center in Texas. She is currently heading UCSD’s newly established Center for Personalized Cancer Therapy at the Moores Cancer Center in San Diego, California.As a physician-scientist, she brings extraordinary expertise, clinical research insights, and business operations experience, while also serving as Chief of the Hematology and Oncology Division at the UCSD School of Medicine. With over 400 peer-reviewed published articles, she has a strong record of competitive grant funding. She also has been the principal investigator for the National Cancer Institute’s U01 Phase I Studies of Targeted Anti-Cancer Agents. Dr. Kurzrock received her medical degree from the University of Toronto School of Medicine. Hosts:Terry Wilcox, Executive Director, Patients RisingDr. Robert Goldberg, “Dr. Bob”, Co-Founder and Vice President of the Center for Medicine in the Public Interest.Kate Pecora, Field Correspondent Links:Dr. Razelle KurzrockCureMatchSamantha SmithG-PactHow AI is helping lung cancer patientsCOVID-19 in cancer patients on systemic anti-cancer therapiesModerna’s COVID-19 Vaccine: What You Need to KnowPatients Rising Concierge Need help?The successful patient is one who can get what they need when they need it. We all know insurance slows us down, so why not take matters into your own hands. Our Navigator is an online tool that allows you to search a massive network of health-related resources using your zip code so you get local results. Get proactive and become a more successful patient right now at PatientsRisingConcierge.orgHave a question or comment about the show, want to suggest a show topic or share your story as a patient correspondent?Drop us a line: podcast@patientsrising.orgThe views and opinions expressed herein are those of the guest(s)/ author(s) and do not reflect the official policy or position of Patients Rising.

Hear from the experts in our conversations on a rare neuro-genetic disorder: Angelman Syndrome (AS). We cover AS diagnosis, new treatment options, and how to connect with the AS community. Experts in this episode include: * Lynne Bird, M.D. - Clinical geneticist and professor at UCSD School of Medicine. * Regina Uribe - Parent advocate of Angelman Syndrome. Her daughter, Natalia (4.5 years old), was diagnosed with Angelman Syndrome when she was 3. * Paula Evans - Parent advocate and Chairperson of FAST (Foundation for Angelman Syndrome Therapeutics). More resources and information for you: raredisease.com/angelman-syndrome

In this episode, Don, a Forensics Psychiatrist with a specialty in Psychoanalysis, in private practice since 1980, discusses his newer endeavors in the treatment of alcoholism. Don personally had a problem with alcoholism starting in his late forties, which led him to treat this disease. Now his role is helping people who ave already realized they have a problem with alcohol and are ready to start treatment. Don Houts, M.D. Links Distinguished Life Fellow, American Psychiatric Association Associate Clinical Professor, Department of Psychiatry, UCSD School of Medicine 2033 San Elijo Avenue, #495 Cardiff by the Sea, CA 92007 Tel: 858-481-8860 Fax: 858-947-3837 Facebook https://pos.li/2gs5gp Scott H Silverman's Happy Hour (Podcast) Links Facebook Page https://pos.li/2ff6na Instagram https://pos.li/2ff6nc Twitter https://pos.li/2ff6nb LinkedIn https://pos.li/2ff6nd Website/Podbean Page https://pos.li/2ff6ne Email, Scott Scott@yourcrisiscoach.com Email, Michael michael@inacitylikeyours.com Scott H Silverman's Links Cell Number 619-993-2738 Facebook https://pos.li/2ff6ny Instagram https://pos.li/2ff6nz Twitter https://pos.li/2ff6nx LinkedIn https://pos.li/2ff6o0 Book, Tell Me No, I Dare You: A Guide for Living a Heroic Life https://pos.li/2ff6nf Website Your Crisis Coach http://pos.li/2gg62e Website Non-Profit https://pos.li/2ff6od Podcast Interview https://pos.li/2ff6oc Website Non-Profit https://pos.li/2ff6od Youtube https://pos.li/2ff6of Youtube https://pos.li/2ff6oe --- Support this podcast: https://anchor.fm/rotm-ent/support

In this episode, Don, a Forensics Psychiatrist with a specialty in Psychoanalysis, in private practice since 1980, discusses his newer endeavors in the treatment of alcoholism. Don personally had a problem with alcoholism starting in his late forties, which led him to treat this disease. Now his role is helping people who ave already realized they have a problem with alcohol and are ready to start treatment. View here on YouTube  https://pos.li/2gs5xe   Don Houts, M.D. LinksDistinguished Life Fellow, American Psychiatric AssociationAssociate Clinical Professor, Department of Psychiatry, UCSD School of Medicine2033 San Elijo Avenue, #495Cardiff by the Sea, CA 92007Tel: 858-481-8860Fax: 858-947-3837Facebook  https://pos.li/2gs5gp Scott H Silverman's Happy Hour (Podcast) LinksFacebook Page  https://pos.li/2ff6naInstagram  https://pos.li/2ff6ncTwitter  https://pos.li/2ff6nbLinkedIn  https://pos.li/2ff6ndWebsite/Podbean Page  https://pos.li/2ff6neEmail, Scott  Scott@yourcrisiscoach.comEmail, Michael  michael@inacitylikeyours.com  Scott H Silverman's LinksCell Number 619-993-2738Facebook  https://pos.li/2ff6nyInstagram  https://pos.li/2ff6nzTwitter  https://pos.li/2ff6nxLinkedIn  https://pos.li/2ff6o0 Book, Tell Me No, I Dare You: A Guide for Living a Heroic Life  https://pos.li/2ff6nfWebsite Your Crisis Coach  http://pos.li/2gg62e Website Non-Profit  https://pos.li/2ff6od Podcast Interview  https://pos.li/2ff6ocWebsite Non-Profit  https://pos.li/2ff6odYoutube  https://pos.li/2ff6ofYoutube  https://pos.li/2ff6oe  Michael Glenn Moore's LinksPersonal Facebook  https://pos.li/2ff6ohPersonal Instagram  https://pos.li/2ff6ogEmail  michaelgmoore333@gmail.com In A City Like Yours (Podcast)Facebook Group  https://pos.li/2ff6niFacebook Page  https://pos.li/2ff6nhInstagram  https://pos.li/2ff6njTwitter  https://pos.li/2ff6nkLinkedIn  https://pos.li/2ff6nlWebsite  http://pos.li/2ff6nmWebsite/Podbean Page  https://pos.li/2ff6nnEmail  michael@inacitylikeyours.com 

Veronica Murphy is Co-Founder and Artistic Director of Write Out Loud (since 2007). With a passion for promoting literature, she has produced six NEA BIG READ initiatives, 11 literary festivals celebrating 19thcentury literature, history and culture, and conceived and executed a Roald Dahl Centenary Celebration. For the past six years she has coordinated the San Diego Regional Poetry Out Loud competition for this national program. She has an extensive professional resume as a performer, costume designer and development director. Veronica is the 2013 recipient of The Deborah Salzer Excellence in Arts Education Award, a 2015 10News Leadership Award and a California English Teachers Association Award of Merit. She has a BA in Theatre Arts from California State University, San Bernardino. Her most important achievement is raising three amazing sons as a single mother.Larry and Debby Kline are collaborative artists, featured in solo exhibitions at Mission Cultural Center for Latino Arts (SF,) California Center for the Arts Museum, La Casa del Tunel Art Center (TJ,) Southwestern College, UCSD Cross Cultural Center, Mesa College and La Jolla Athenaeum. Group exhibitions include Indiana State Museum, Torrance Art Museum and Museum on the Seam (Israel.) We have been featured in periodicals such as Utne and Orion, and books including “The Artists Guide,” and “Design and Ethics: Reflections on Practice.” Awards include three grants from The Gunk Foundation (NY) and grants from Potrero Nuevo Fund (SF,) Center for Cultural Innovation (LA,) UCIRA (SD) and San Diego Art Prize. We were featured in an Emmy Award winning episode of ArtPulse TV and were artists-in-residence at San Diego Natural History Museum, Torrance Art Museum, Center for Land Use Interpretation, Building Bridges Art Exchange and currently UCSD School of Medicine. “Bruce’s Story” is our third illustration project for Write Out Loud San Diego.Chapters is a multi-part Creative + Cultural Podcast series concerning the history and the lessons of civil rights violations or civil liberties injustices carried out against communities or populations—including civil rights violations or civil liberties injustices that are perpetrated on the basis of an individual’s race, national origin, immigration status, religion, gender, or sexual orientation.This project was made possible with support from Chapman University and The California Civil Liberties Public Education Program, a state-funded grant project of the California State Library. Visit chapman.edu and library.ca.gov.Guests: Veronica Murphy and Larry and Debby KlineHosts: Jon-Barrett Ingels and Jonelle Strickland

Dr. J. Silvio Gutkind sheds light on his work and life since the beginning of COVID restrictions. Dr. J. Silvio Gutkind is a Professor of Pharmacology based at UCSD School of Medicine. A large component of his work is centered around dysregulated signaling in cancer and the development of novel mechanism-based cancer therapies. In this episode, Dr. J. Silvio Gutkind highlights how his past experience proves useful in current COVID times and potential benefits the changes in work environments can do for future collaborations.

Neurobiologist Caitlin Thompson is a certified kambo practitioner, administering unique traditional frog medicine rituals. Caitlin is also the founder of a nutritional supplement company called EntheoZen. She’s an independent scientific researcher and research associate at UCSD School of Medicine and is currently conducting research on the potential of psychedelic compounds as a novel approach to autoimmune conditions as well as the first human kambo studies. In this episode, Caitlin Thompson discusses what we know and what we don’t know about kambo is and how it actually works. Having served kambo over 800 times, she shares the physiological and psychological changes people undergo when they experience the cocktail of peptides present in kambo. Caitlin also discusses the progress being made on creating synthetic variations of kambo. She explains how she’s observed kambo to be most effective for those who have insufficient detox pathways and usually have trouble clearing out metals, mold toxins and toxins in general, and those who have fairly low neurotransmitter production. She also discusses how she titrates dosages in her ceremonies.   In this episode: Where the kambo secretions come from and what ethical harvests are like. Why Caitlin uses the minimum effective dose as a kambo practitioner How leaky gut can lead to a herxheimer reaction after kambo use How often you may want to  use kambo depending on your specific needs How kambo may be useful for those with chronic illness, autoimmune disorders, Lyme disease, and Epstein-Barr.   Quotes: “I suffered with a chronic illness for most of my life and I sort of stumbled upon this [kambo] practice and accidentally started recovering from it. And the contrast between recovering from the illness and noticing how sick I used to be was quite startling. And that gap got bigger and bigger as time went on.” [4:00] “They [tribal hunters] would find that it [kambo] is a bit of an adaptogenic sort of substance with increased resilience, endurance and alleged reduced need for food or water, and I’ve also heard something about it covering their human scent, allowing them to hide from animals more effectively.” [17:30] “I try not to be dogmatic about anything but it’s hard because [...] it’s really great for inflammatory and immune dysfunction conditions, especially when there’s a psychosomatic element to it.” [33:45]  “The kambo interfaces with the chemical systems that are the interface between our spirit and our physiology. I think psychedelics hit on that as well. They work with these molecular systems, these receptor-sites that happen to sort of tickle where the soul meets the meat. I see these amazing emotional and spiritual resolutions happen for people that results in these physiological and biological cascades throughout the body.”  [35:10]   Links: Get 20% off everything at Octagon Biolabs (octagonbiolabs.com) with coupon code 'plantmedicine' Medicine Frog kambo - Caitlin’s Practice EntheoZen - Caitlin’s Supplement Company International Association of kambo Practitioners Porangui

"Episodic memory involves conscious experiences being encoded. Same goes for semantic and autobiographical memories. All varieties of memories come in through conscious moments of recall. So, I think that consciousness is the means by which any kinds of memories are established."- Bernard Baars, PhD, originator of global workspace theory and global workspace dynamics, former Senior Fellow in Theoretical Neurobiology at the Neurosciences Institute in La Jolla, CA, editor in Chief of the Society for MindBrain Sciences, and a recipient of the 2019 Hermann von Helmholtz Life Contribution Award by the International Neural Network Society.EPISODE 11: Roundtable Part Four "Brain Regions and Neural Functions Critical to Conscious States" In the final episode of their roundtable talks, originator of Global Workspace Theory Bernard Baars, neuroscientist David Edelman, and developmental neuropsychiatrist Dr. Jay Giedd conclude their discussion by analyzing the brain areas which are critical for higher brain function, neuroimaging techniques associated with detecting conscious experiences, and the possible existence of consciousness in non-mammalian animals.  Get your 40% Discount for your copy of Bernie Baars' acclaimed new book On Consciousness: Science & Subjectivity - Updated Works on Global Workspace TheoryGO TO: https://shop.thenautiluspress.com/collections/baars APPLY DISCOUNT CODE AT CHECKOUT: "PODCASTVIP" Talking Points00:03 – Introduction by David Edelman02:09 – The Role of Thalamus and Cortex in Higher Brain Processing08:08 – Is Memory Fundamental to Consciousness12:14 – Brain Variations Between Mammals and Other Animals16:22 – Differences Between Sleep and Awake States in the Human Brain Summary of the ConversationIn this absorbing episode of ‘On Consciousness,’ Bernard Baars, David Edelman, and developmental neuropsychiatrist Dr. Jay Giedd initiate the conversation by considering the functional aspects of the brain that are believed to be absolutely critical to consciousness.Bernie, Jay, and David ponder the role of cortex and thalamus in higher brain function, including conscious processing. Bernie underlines the problem of considering the linkage between thalamus and cortex as merely a simple feedback loop. From an engineering perspective, this sort of circuit could not possibly work as such an arrangement would inevitably, as Bernie puts it, lead to effective failure of the thalamocortical circuit. Instead, it seems to be the case that the cortex functions in a state of near-criticality. As Jay indicates, this implies that the cortex is always at a tipping point, i.e., close to a phase transition and “always ready to be influenced.”Elucidating the neurobiology of consciousness has been somewhat hindered by technical hurdles. But, despite the spatial and temporal limitations of current neurophysiological and imaging technologies, David observes that certain aspects of brain anatomy—including cortex and thalamus—have been established as the sine qua non of conscious experience in mammals. In an optimistic vein, Jay offers that new combinations of existing techniques (such as MEG, EEG, and fMRI) may soon yield a much clearer picture.Next, Edelman, Baars, and Giedd consider the idea that certain higher neural processes are central to consciousness, even though those processes may often function independently of any state of awareness. Memory, which seems to be fundamental to conscious experience, is one such process. While memory and recall figure prominently in conscious experience, it’s certainly the case that some varieties of memory are regularly engaged during non-conscious states and behaviors.The trio concludes the conversation by reflecting on the prospect of consciousness as a biological phenomenon. Additionally, they consider the possibility of consciousness in animals distant from the mammalian line and as it is the case of the octopus, a creature separated from the vertebrate radiation by more than half a billion years. The octopus as a possible test case for consciousness beyond the realm of vertebrates is particularly tantalizing, given that, unlike mammals, it has neither a cerebral cortex nor a thalamus. BiosDr. Jay GieddChair of child psychiatry at Rady Children's Hospital-San Diego and director of child and adolescent psychiatry, Dr. Giedd is also a professor of psychiatry at UCSD School of Medicine, and professor in the Dept of Population, Family and Reproductive Health at Johns Hopkins Bloomberg School of Public Health. Dr. Giedd was chief of the Section on Brain Imaging, Child Psychiatry Branch of the National Institute of Mental Health (NIMH). His widely published research and expertise evaluates how the child's brain develops in health and illness, the factors that influence development and how to optimize treatments to take advantage of the child's changing brain. Jay and his award winning work were featured in the PBS 2 part series "Brains on Trial" hosted by Alan Alda. David Edelman, PhD: A neuroscientist and currently Visiting Scholar in the Department of Psychological and Brain Sciences at Dartmouth College, David has taught neuroscience at the University of San Diego and UCSD. He was Professor of Neuroscience at Bennington College until 2014 and visiting professor in the Dept of Psychology, CUNY Brooklyn College from 2015-2017.He has conducted research in a wide range of areas, including mechanisms of gene regulation, the relationship between mitochondrial transport and brain activity, and visual perception in the octopus. A longstanding interest in the neural basis of consciousness led him to consider the importance—and challenge—of disseminating a more global view of brain function to a broad audience.Bernard Baars is best known as the originator of global workspace theory and global workspace dynamics, a theory of human cognitive architecture, the cortex and consciousness. Bernie is a former Senior Fellow in Theoretical Neurobiology at the Neurosciences Institute in La Jolla, CA, and Editor in Chief of the Society for MindBrain Sciences. He is author of many scientific papers, articles, essays, chapters, and acclaimed books and textbooks. Bernie is the recipient of the 2019 Hermann von Helmholtz Life Contribution Award by the International Neural Network Society, which recognizes work in perception proven to be paradigm changing and long-lasting. He teaches science. It keeps him out of trouble. *Watch Episode 11 on Our YouTube Channel!#podbean #podcast #spotify #itunes #podcasting #podcastlife #stitcher #podcasts #applepodcasts #googleplay #youtube #podcasters #podcaster #soundcloud #podcastshow #newpodcast #googlepodcasts #applepodcast #iheartradio #spotifypodcast #itunespodcast #podcastmovement #entertainment #castbox #radio #subscribe #listen #neuroscience #psychology #brain #globalworkspace #gwt #bernardbaars #davidedelman #jaygiedd #brainscience #sciencepodcast #science 

"All models are wrong, but some are useful." And I think ultimately that's the test of a construct like Global Workspace Theory - does it lead us to greater knowledge? Does it suggest areas of research? Does it make predictions that we can test? And that's why I think Global Workspace Theory has stood the test of time. It has succeeded on all of those fronts."- Dr. Jay Giedd, Chair of child psychiatry at Rady Children's Hospital - San Diego and director of child and adolescent psychiatry, professor of psychiatry at UCSD School of Medicine, and professor in the Dept of Population, Family and Reproductive Health at Johns Hopkins Bloomberg School of Public Health.EPISODE 10: Roundtable Part Three - Global Workspace Theory - Brain Aspects and Evidence with Dr. Jay GieddIn the third part of their roundtable talk, neuroscientist David Edelman, Bernard Baars, originator of the global workspace theory and global workspace dynamics, and developmental neuropsychiatrist Jay Giedd consider underlying neural processes and anatomical features of Global Workspace Theory and continue on their journey to unravel the complexities surrounding conscious experiences.How does consciousness come together in the brain? How does memory figure into conscious experience? Knowing how we acquire coherent perceptual insights about the world and then commit those insights to memory, can we tune the learning process to optimize the acquisition of new skills?Get your 40% Discount for your copy of Bernie Baars' acclaimed new book On Consciousness: Science & Subjectivity - Updated Works on Global Workspace TheoryGO TO: https://shop.thenautiluspress.com/collections/baars APPLY DISCOUNT CODE AT CHECKOUT: "PODCASTVIP"  Talking Points00:00 – Intro by David Edelman.02:09 – David Edelman prompts Baars to summarize the key points of the Global Workspace Theory.07:41 – Has Global Workspace Theory been interpreted correctly by scientists? What did people get right and wrong about it?09:11 – Baars argues against the idea that consciousness is a byproduct of human biology and that instead the two are interconnected.11:09 – Jay Giedd on how Global Workspace Theory served as a great standing ground for research in the field of consciousness.12:41 - The trio continue the conversation by discussing the virtually limitless potential of the human brain to learn novel information.15:36 - Jay Giedd discusses how some human skills are diminishing with the advancement of technology.18:02 - Edelman and Giedd engage in the process of defining consciousness and ponder upon the notion of what is necessary to create a conscious experience.21:26 - Edelman asks Baars to explain from the standpoint of Global Workspace Theory, which mammalian brain areas are involved in the conscious process.26:24 - Baars, Giedd, and Edelman discuss the limitations of brain imaging technology. Summary of the ConversationHow does consciousness come together in the brain? How does memory figure into conscious experience? Knowing how we acquire coherent perceptual insights about the world and then commit those insights to memory, can we tune the learning process to optimize the acquisition of new skills?  In this engrossing episode of ‘On Consciousness,' Bernard Baars, David Edelman, and developmental neuropsychiatrist Jay Giedd consider Global Workspace Theory (GWT) and its underlying neural processes and anatomical features, as well as the development of the imaging technology which has afforded a detailed view of brain activity in near-real time that appears to support GWT.To begin the discussion, Bernie provides an outline of GWT. He points to the paradox that our thought processes seem to unfold serially, yet the brain architecture underlying those thought processes resembles a collection of massively parallel processors. With this insight in mind, Bernie proposed a Global Workspace in which nonconscious processes arising in different neural regions come together, those processes are somehow polled, and the most ‘popular’ among them gets broadcast throughout the cerebral cortex, amounting to a sort of ‘ignition’ of conscious experience. From Bernie’s summary of GWT, the discussion turns to perceptual learning. As humans negotiating an incredibly complex world, one of our greatest advantages is a long maturation period that affords us the time to acquire many sophisticated skills. Given time, a rich suite of sensory faculties, a large brain, and a good understanding of the neural processes underlying learning and memory, can we somehow optimize the acquisition of specialized skills? Elaborating on this, Jay proposes the prospect of replacing native skills that are losing ground to technology with new ones — sophisticated pattern recognition being just one example. Human beings are still much better at pattern recognition than the most powerful supercomputers. Central to conscious perception is the ability of the brain to bind perceptual input from different sensory organs into cohesive, unified percepts that somehow hold together and persist in memory. Jay observes that during development, there must be an accretive weaving together of percepts which at some point passes a threshold of complexity, yielding conscious experience. But, when do developing humans and some non-human animals cross this rubicon of awareness? New imaging techniques, including fMRI and MEG, have made it possible for researchers to record some of the functional signatures of integration of percepts. Someday, using improved versions of such techniques, we may increasingly observe the emergence of complex states of consciousness in human infants and young non-human animals.At the close of the discussion, Bernie, Jay, and David reflect on the work of Wilder Penfield, whose contributions included the identification of numerous brain regions with particular functional specializations and the seminal insight that the cerebral cortex is the organ of mind. The pioneering refinements in open skull surgery which made possible these contributions also led Penfield to observe that variations in blood coloration associated with changes in flow were strongly correlated with differences in brain area activation. In a sense, as Jay remarks, Penfield’s observation presaged the development of fMRI. Tempering the promise of neuroimaging, Jay and David conclude the conversation by pondering the shortcomings of fMRI, including limits on spatial and temporal resolution, extreme computational processing (which can lead to ‘data massaging’), and the danger of overinterpreting results. BiosDr. Jay GieddChair of child psychiatry at Rady Children's Hospital-San Diego and director of child and adolescent psychiatry, Dr. Giedd is also a professor of psychiatry at UCSD School of Medicine, and professor in the Dept of Population, Family and Reproductive Health at Johns Hopkins Bloomberg School of Public Health. Dr. Giedd was chief of the Section on Brain Imaging, Child Psychiatry Branch of the National Institute of Mental Health (NIMH). His widely published research and expertise evaluates how the child's brain develops in health and illness, the factors that influence development and how to optimize treatments to take advantage of the child's changing brain. Jay and his award winning work were featured in the PBS 2 part series "Brains on Trial" hosted by Alan Alda. David Edelman, PhD: A neuroscientist and currently Visiting Scholar in the Department of Psychological and Brain Sciences at Dartmouth College, David has taught neuroscience at the University of San Diego and UCSD. He was Professor of Neuroscience at Bennington College until 2014 and visiting professor in the Dept of Psychology, CUNY Brooklyn College from 2015-2017.He has conducted research in a wide range of areas, including mechanisms of gene regulation, the relationship between mitochondrial transport and brain activity, and visual perception in the octopus. A longstanding interest in the neural basis of consciousness led him to consider the importance—and challenge—of disseminating a more global view of brain function to a broad audience.Bernard Baars is best known as the originator of global workspace theory and global workspace dynamics, a theory of human cognitive architecture, the cortex and consciousness. Bernie is a former Senior Fellow in Theoretical Neurobiology at the Neurosciences Institute in La Jolla, CA, and Editor in Chief of the Society for MindBrain Sciences. He is author of many scientific papers, articles, essays, chapters, and acclaimed books and textbooks. Bernie is the recipient of the 2019 Hermann von Helmholtz Life Contribution Award by the International Neural Network Society, which recognizes work in perception proven to be paradigm changing and long-lasting. He teaches science. It keeps him out of trouble. *Watch Episode 10 on Our YouTube channel!#podbean #podcast #spotify #itunes #podcasting #podcastlife #stitcher #podcasts #applepodcasts #googleplay #youtube #podcasters #podcaster #soundcloud #podcastshow #newpodcast #googlepodcasts #applepodcast #iheartradio #spotifypodcast #itunespodcast #podcastmovement #entertainment #castbox #radio #subscribe #listen #neuroscience #psychology #brain #globalworkspace #gwt #bernardbaars #davidedelman #jaygiedd #brainscience #sciencepodcast #science

Ira Pastor, ideaXme life sciences ambassador and founder of Bioquark, interviews Dr. Christine Moutier, MD, Chief Medical Officer, at the American Foundation for Suicide Prevention (AFSP). Ira Pastor comments: According to the World Health Organization (WHO), close to 800,000 people die due to suicide every year, which is one person every 40 seconds. Suicide is a global phenomenon and occurs throughout the lifespan, and there are indications that for each adult who died by suicide, there may have been more than 20 others attempting suicide. According to the U.S. Centers for Disease Control and Prevention (CDC) "Leading Causes of Death Report", in 2017 suicide was the tenth leading cause of death overall in the United States, claiming the lives of over 47,000 people; Suicide was the second leading cause of death among individuals between the ages of 10 and 34, and the fourth leading cause of death among individuals between the ages of 35 and 54. There were more than twice as many suicides in the United States as there were homicides. Aiding Suicide Prevention Through Psychiatry Dr. Christine Moutier, MD is the Chief Medical Officer at the American Foundation for Suicide Prevention. Dr. Moutier earned her medical degree and training in psychiatry at the University of California, San Diego, and has been a practicing psychiatrist, professor and dean in the UCSD School of Medicine, medical director of the Inpatient Psychiatric Unit at the VA Medical Center in La Jolla, and has been clinically active with diverse patient populations, such as veterans, Asian refugee populations, as well as physicians and leaders with mental health conditions. She also served as co-investigator for the Sequenced Treatment Alternatives to Relieve Depression study (STAR*D), a large National Institute of Mental Health (NIMH) trial on the treatment of refractory depression. Dr. Christine Moutier’s Career in Psychiatry  Dr. Moutier has authored numerous articles and book chapters for publications such as the Journal of the American Medical Association, Academic Medicine, the American Journal of Psychiatry, the Journal of Clinical Psychiatry, Psychiatric Times, Depression and Anxiety, and Academic Psychiatry. She has testified before the U.S. Congress and spoken at the White House, she was the host of AFSP’s documentary on surviving suicide loss, The Journey, and has appeared as an expert in The New York Times, The Washington Post, Time magazine, The Economist, The Atlantic, the BBC, NBC, CNN and other print and television outlets. She is also a member of the National Academy of Medicine (NAM) Action Collaborative on Clinician Well-Being and Resilience. On this episode we will hear from Dr. Moutier about: Her background and how she got interested in medicine, in psychiatry, and became a thought leader in the area of suicide prevention. The American Foundation for Suicide Prevention (AFSP). The top 10 learnings of why so many people are dying by suicide in 2020. The Sequenced Treatment Alternatives to Relieve Depression (STAR*D) collaborative study on the treatment of recalcitrant depression, a leading driver of suicide. Suicide connections to modern stressors/traumas such as the Coronavirus pandemic. Nutritional interventions to help prevent depression related suicide. The National Academy of Medicine's Action Collaborative on Clinician Well-Being and Resilience and the understandings of challenges related to clinician well-being, stress and burnout, and suicide. This interview is in American English Credits: Ira Pastor interview video, text, and audio. Follow Ira Pastor on Twitter: @IraSamuelPastor If you liked this interview, be sure to check out our interview with Dr. Ekaterina Malievskaia! Follow ideaXme on Twitter: @ideaxm On Instagram: @ideaxme On YouTube: ideaxme Find ideaXme across the internet including on iTunes, SoundCloud, Radio Public, TuneIn Radio, I Heart Radio, Google Podcasts, Spotify and more. ideaXme is a global podcast, creator series and mentor programme. Our mission: Move the human story forward!™ ideaXme Ltd.

"You highlighted the difference that makes a difference. Тhis is not only a neat catchphrase, but there's also something very deep about it. And sleep, in fact, is a really interesting aspect of behavior, that maybe gives us a window on the difference between conscious and non-conscious processes in the brain, because there is a distinct difference and it is recordable."- David Edelman, PhD, A neuroscientist and a Visiting Scholar in the Department of Psychological and Brain Sciences at Dartmouth College EPISODE 9: Roundtable Part Two - What is the Difference That Makes a Difference?  In a continuation from their previous conversation, Neuroscientist David Edelman and Developmental Neuropsychiatrist Jay Giedd, Professor of Psychiatry at UCSD School of Medicine and Director of Child & Adolescent Psychiatry at Rady Children's Hospital are joined by Bernard Baars, the originator of the global workspace theory and global workspace dynamics, a theory of human cognitive architecture, the cortex and consciousness. In this contemplative conversation the trio touches on subjects involving how consciousness gets defined, the developing process of an adolescent human brain, and the role that sensory organs play in an individual's perception of reality. Get your 40% Discount for your copy of Bernie Baars' acclaimed new book On Consciousness: Science & Subjectivity - Updated Works on Global Workspace TheoryGO TO: https://shop.thenautiluspress.com/collections/baars APPLY DISCOUNT CODE AT CHECKOUT: "PODCASTVIP" Talking Points0:00 – Intro by David Edelman.2:00 – David Edelman welcomes Bernard Baars to the conversation.2:31 – Edelman initiates the discussion by revealing what consciousness means to him and how it could be reduced to main aspects (An idea which is based on his father’s views).6:22 – Baars points out that the exploration of consciousness is an idea that has been an inevitable part of humanity and a necessary trait.9:40 – Edelman and Baars discuss the importance of being able to socially broadcast your model of the world as part of the conscious experience.13:17 - Giedd and Edelman discuss whether having some type of social skills is a requirement for consciousness or if it is instead a product of it.19:12 – Jay makes a connection between social skills and the development of the cortex, its structure, and how important it appears to be for the emergence of consciousness22:12 – The development and integration of neuronal connections in the brain, responsible for essential bodily functions such as heart rate and breathing.24:35 – Is consciousness a constant or are there variations of it?26:22 – The uniqueness of the olfactory system and its close interconnectedness to the emotional system.30:31 – The sensation of smell and the human brain’s inability to recreate a memory of smell, the way it would for a visual image32:11 – Baars steers the conversation towards visual perceptional differences.34:55 – Jay Giedd discusses some of the rare conditions in humans which allow for the richer perception of external stimuli  Summary of the ConversationBernard Baars has often referred to consciousness as the difference that makes a difference. When we reflect on our everyday experience versus the absence of anything attended to or recalled, as is the case during a deep, dreamless sleep or under general anesthesia — that difference which distinguishes conscious experience from the rest of our mental lives becomes quite obvious.But, how would we characterize that difference?What is it about a particular animal’s makeup — its nervous and sensory systems, its behavior, its social interactions — that singles out that animal as truly conscious?In this episode of ‘On Consciousness’, Baars, Edelman, and Giedd explore these questions in a thought-provoking discussion, starting with their perspectives on the nature of consciousness. To begin with, David posits a relatively straightforward definition of consciousness: namely, the weaving together of different sensory threads into a coherent unified percept and the persistence of that percept in memory. Bernie then offers that humans have studied consciousness for millennia, and out of that long rumination has come the realization that teaching and learning — the process of communicating and internalizing information — is an interactive exchange of conscious thought. This social domain of conscious experience could therefore be subsumed within an operational definition of awareness — at least in the human case. As David points out (and Jay amplifies) Bernie’s emphasis on the kind of social interchange of conscious percepts that occurs between humans doesn't take into account the long history of life on earth and in particular the many animals with complex brains and elaborate sensory faculties that have preceded us.Human sociality is a recent evolutionary innovation, and it seems clear that some form of consciousness existed long before we came along. And, while Bernard emphasizes the idea that human sociality accommodates our conscious experience, Jay flips this on its head, suggesting instead that consciousness may be what ultimately affords our particular social lives as humans.Moreover, for many non-human animals, survival and reproduction are contingent on social skills — but this was true long before humans walked the earth. In any case, as Jay points out, we should be able to infer whether an animal has the capacity to convey its interpretation of reality to others from the structure and function of its nervous system. Such an inference would be strongly suggestive of a rich conscious life.Next, the conversation focuses on the role of certain brain structures and sensory faculties in defining and elaborating conscious experience. In the case of human development, we can track the emergence of different perceptual and cognitive capacities, as well as the elaboration of underlying brain areas and circuitry, from infancy well into adulthood. Thus, as Jay suggests, we could in principle observe as the capacity to weave together sensory percepts into a neural representation emerges and is elaborated in the brain of a young child. In this regard, Jay asks two questions:   1) Can consciousness be considered as being on a ‘sliding scale’ during development?   2) Would we expect developing humans to get better at weaving together conscious percepts as they grow older?  With regard to evolution, radical distinctions between our sensory organs and those of animals quite distant from our phylogenetic line suggest that the varieties of conscious experience must be legion among animals. Even among humans, differences in sensory equipment must necessarily give rise to differences in conscious experience. Individuals with a condition known as Tetrachromacy — a genetic mutation that is expressed as an extra photopigment — can perceive finer gradations in the spectrum of visible light than the rest of us and are therefore capable of making color distinctions we would certainly miss. The upshot of this lively exchange is that there is, indeed, a difference that makes a difference at the core of conscious experience, and it can be both observed in developing humans and inferred from the rich evolutionary history of complex life on earth. Though Bernie, Jay, and David barely scratch the surface of this tantalizing difference here, they provide listeners with ample armamentarium to forge ahead and continue the intellectual journey on their own.BIOSDr. Jay GieddChair of child psychiatry at Rady Children's Hospital-San Diego and director of child and adolescent psychiatry, Dr. Giedd is also a professor of psychiatry at UCSD School of Medicine, and professor in the Dept of Population, Family and Reproductive Health at Johns Hopkins Bloomberg School of Public Health. Dr. Giedd was chief of the Section on Brain Imaging, Child Psychiatry Branch of the National Institute of Mental Health (NIMH). His widely published research and expertise evaluates how the child's brain develops in health and illness, the factors that influence development and how to optimize treatments to take advantage of the child's changing brain. Jay and his award winning work were featured in the PBS 2 part series "Brains on Trial" hosted by Alan Alda. David Edelman, PhD: A neuroscientist and currently Visiting Scholar in the Department of Psychological and Brain Sciences at Dartmouth College, David has taught neuroscience at the University of San Diego and UCSD. He was Professor of Neuroscience at Bennington College until 2014 and visiting professor in the Dept of Psychology, CUNY Brooklyn College from 2015-2017.He has conducted research in a wide range of areas, including mechanisms of gene regulation, the relationship between mitochondrial transport and brain activity, and visual perception in the octopus. A longstanding interest in the neural basis of consciousness led him to consider the importance—and challenge—of disseminating a more global view of brain function to a broad audience.Bernard Baars is best known as the originator of global workspace theory and global workspace dynamics, a theory of human cognitive architecture, the cortex and consciousness. Bernie is a former Senior Fellow in Theoretical Neurobiology at the Neurosciences Institute in La Jolla, CA, and Editor in Chief of the Society for MindBrain Sciences. He is author of many scientific papers, articles, essays, chapters, and acclaimed books and textbooks. Bernie is the recipient of the 2019 Hermann von Helmholtz Life Contribution Award by the International Neural Network Society, which recognizes work in perception proven to be paradigm changing and long-lasting. He teaches science. It keeps him out of trouble. *Watch Episode 9 on Our YouTube Channel!  #podbean #podcast #spotify #itunes #podcasting #podcastlife #stitcher #podcasts #applepodcasts #googleplay #youtube #podcasters #podcaster #soundcloud #podcastshow #newpodcast #googlepodcasts #applepodcast #iheartradio #spotifypodcast #itunespodcast #podcastmovement #entertainment #castbox #radio #subscribe #listen #neuroscience #psychology #brain #globalworkspace #gwt #bernardbaars #davidedelman #jaygiedd #brainscience #sciencepodcast #science 

"I want to try to understand consciousness from a neuroanatomy and neuro-function standpoint. What would consciousness look like in a brain scanner and other types of imaging? What are we looking for, in a sense, and could I predict from basically the architecture and the anatomy, that this could be conscious, and this would not be able to be conscious?"- Dr. Jay Giedd, Developmental Neuropsychiatrist, UCSD School of Medicine, Rady Children's Hospital, and Johns Hopkins EPISODE 8: Roundtable Part One – The Developing Brain & Consciousness – A thoughtful discussion exploring some fundamental issues that confront the science of consciousness. Namely, how do we define consciousness? What does that term mean? Where do we even start?Neuroscientist David Edelman and Developmental Neuropsychiatrist Jay Giedd, Professor of Psychiatry at UCSD School of Medicine and Director of Child & Adolescent Psychiatry at Rady Children's Hospital talk candidly about our understanding of the complex - and often tantalizing - nature of consciousness. In the context of the developing human brain, how can we understand consciousness? To many of us, consciousness seems like a simple, commonsense notion. When we’re awake, we all know that we are, more often than not, aware—of the world, of our thoughts and emotions, of our feeling states (i.e., hunger, thirst, pain, etc.), among others. When we fall into a deep, dreamless sleep, that awareness slips away. But, this notion is actually quite confounding—particularly when one considers that there must be a specific moment during development when the brain transitions from a small, non-conscious organ comprising a few dozen cells to a complex, 86 billion-cell nexus of conscious feelings, emotions, and thoughts.When, precisely, does that moment occur? In the womb? When we are just a few weeks old? These are the key questions that David Edelman and developmental neuropsychiatrist Jay Giedd ponder in this podcast.A lively back-and-forth ensues as the two neuroscientists bring their respective backgrounds to bear on the emergence and nature of consciousness during development:one, a neuroscientist focused on consciousness in non-human animals and the other,a psychiatrist and neuroscientist who has spent more than thirty years exploring the growth and development of the human brain from embryogenesis through childhood and adolescence well into adulthood.Along the way, David and Jay reinforce the notion that memory is a sine qua non of conscious states. As they learn to negotiate the world, very young infants experience the world with their developing senses, remember certain experiences, and then modify their behaviors accordingly.But, when do the first substantive memories actually form? There is certainly a Rubicon that is crossed; we just haven’t figured out when it happens or what that passage looks like. Memory is a ubiquitous faculty across the animal kingdom; even relatively simple animals like the humble marine snail Aplysia can learn and remember at a fundamental level.Are the different developmental stages of memory in growing infants comparable to the increasingly sophisticated memory faculties found in the nervous systems of ever more complex organisms?     Roundtable Part One Talking Points0:03 – Opening lines by David Edelman.0:58 – Jay Giedd introduces himself, his background in psychiatry, robotics, and reproductive medicine, and how all of it ties together as he studies brain development.1:52 – David Edelman opens the conversation by asking about Jay Giedd’s idea ofconsciousness.2:15 – Jay Giedd looks at consciousness from the perspective of the developing brain in a fetus, particularly at what point does consciousness arise and how would that be detectable through a brain scanner.3:14 – Edelman makes a connection between Giedd’s outlook on consciousness with that of the brain’s behavior during a sleeping state.6:02 – Jay Giedd points out that a memory appears to be essential for the rise of consciousness, and how sleep, a process which no animal escaped from evolutionarily, is essential for proper memory formation.8:57 – David Edelman describes what happens in the brain while a person is asleep and proposes the idea that consciousness may have a variety of forms and that a brain’s sleeping state may be one of several.10:11 – Giedd brings up the role of dreams and our vague understanding of them. Get your 40% Discount for your copy of Bernie Baars' acclaimed new book On Consciousness: Science & Subjectivity - Updated Works on Global Workspace TheoryGO TO: https://shop.thenautiluspress.com/collections/baars APPLY DISCOUNT CODE AT CHECKOUT: "PODCASTVIP" David and Jay highlight important questions that may provide important waypoints along the way. Towards the end of their conversation, David and Jay consider the transition from wakefulness to deep non-REM sleep and its signal importance as a transition between conscious and non-conscious states during which changes in brain activity occur that we can actually study—and that provides clues as to the nature of consciousness.Sigmund Freud once said, “The interpretation of dreams is the royal road to a knowledge of the unconscious activities of the mind.” Though Freud was clearly referring to understanding a behavioral manifestations of a dreaming brain that may now be understood to be conscious in some sense (albeit mostly a matter of the cerebral cortex, cut off from the world, “talking to itself”), we can certainly invoke his spirit as a scientific observer in pursuit of the verifiable truth when we say that investigating the passage from wakefulness to deep sleep and back again may well help pave the royal road to understanding consciousness in the brain, whether still in the throes of development or fully formed. Quotes from Episode 8 "There's a kind of a commonplace notion of what consciousness is. Nearly everyone sort of knows what we mean when we invoke the term. But when it comes to the actual hard-nosed scientific aspect, we really haven't arrived at any sort of consensus; at least as far as I know, there's no real consensus as to what we mean when we bring up the term, ‘consciousness.'" -- David Edelman "When do we cross that Rubicon from non-conscious processing to conscious processing? And one of the aspects that Bernie Baars and in fact my late father, Nobel Laureate Gerald Edelman delved into was certain brain states -- certain behavioral states, actually -- that have underlying brain states that are indicative perhaps of "a difference that makes a difference." And one example might be the contrast between waking states and say a dreamless deep sleep. And the fact that we can observe through brain imaging -- through a variety of techniques -- we can observe a real difference in function there." -- David Edelman "We all have different paths that we've taken to come to the study of consciousness and my path has been looking at it from the development of the brain. I'm a child, adolescent, and geriatric psychiatrist by training. I'm the Chief of Child and Adolescent Psychiatry here at UC San Diego and a professor at Fukui University in Japan in Robotics, and at Johns Hopkins in Reproductive Medicine. But what ties together my interest has been the brain and how it changes throughout life. What sort of things influenced it, in good ways and in bad ways. And looking at the brain and health and illness and what permeates all of these interests is consciousness, which is in some ways the most basic and simple notion, and also one of the most difficult to grasp." -- Jay Giedd "I want to try to understand consciousness from a neuroanatomy and neuro-function standpoint. What would consciousness look like in a brain scanner and other types of imaging? What are we looking for, in a sense, and could I predict from basically the architecture and the anatomy, that this could be conscious, and this would not be able to be conscious?" -- Jay Giedd "For me, consciousness is more about questions than answers, even after 30 years of trying. But the memory aspect is actually a really good place to start. To what extent do babies in the womb have a memory, or even after they're born?" -- Jay Giedd BIOSDr. Jay GieddChair of child psychiatry at Rady Children's Hospital-San Diego and director of child and adolescent psychiatry, Dr. Giedd is also a professor of psychiatry at UCSD School of Medicine, and professor in the Dept of Population, Family and Reproductive Health at Johns Hopkins Bloomberg School of Public Health.  Dr. Giedd was chief of the Section on Brain Imaging, Child Psychiatry Branch of the National Institute of Mental Health (NIMH). His widely published research and expertise evaluates how the child's brain develops in health and illness, the factors that influence development and how to optimize treatments to take advantage of the child's changing brain. Jay and his award winning work were featured in the PBS 2 part series "Brains on Trial" hosted by Alan Alda. David Edelman, PhD: A neuroscientist and currently Visiting Scholar in the Department of Psychological and Brain Sciences at Dartmouth College, David has taught neuroscience at the University of San Diego and UCSD. He was Professor of Neuroscience at Bennington College until 2014 and visiting professor in the Dept of Psychology, CUNY Brooklyn College from 2015-2017. He has conducted research in a wide range of areas, including mechanisms of gene regulation, the relationship between mitochondrial transport and brain activity, and visual perception in the octopus. A longstanding interest in the neural basis of consciousness led him to consider the importance—and challenge—of disseminating a more global view of brain function to a broad audience. *Watch Episode 8 on Our YouTube Channel**Roundtable Episodes of the podcast “On Consciousness with Bernard Baars” were recorded and filmed in the dining room of the La Jolla house that was my father’s home for more than 20 years. These explorations of consciousness are a special tribute to David's Dad, Nobel Laureate Gerald Edelman, and his verdant imagination, immense creativity, prodigious output, and the many discussions about the scientific study of consciousness and biological science generally that we had within these four walls.

Why are we conscious? Is cortex the organ of mind? Throughout human history, people have perceived the conscious brain as the great nexus of human life, of social relationships, of their personal identities and histories, in encounters with new challenges. In Episode #5 of the podcast On Consciousness, Bernard Baars, originator of GWT, talks with neuroscientists David Edelman and Jay Giedd, roboticist Jeff Krichmar, magician Mark Mitton, and editor Natalie Geld about our growing understanding of the many relationships between the structure and functions of the brain and our own private experiences.Discover the conscious brain.Consciousness under its many labels and manifestations is widely seen to be one of the core mysteries of life. A great many therapeutic approaches can be viewed in a global workspace framework, including traditional psychodynamics and depth psychology, but also cognitive behavioral techniques, and, indeed, many other kinds of carefully studied human functions. Making progress in understanding consciousness therefore has an endless number of implications - philosophical, metaphysical, scientific, medical, clinical, and practical."Baars' Global Workspace Theory is practical and elegant, addressing both conscious and unconscious activity. If anyone thinks there is a "hard problem" in this field, they need to read On Consciousness before they make that assumption." ~Stanley Krippner, PhD, Professor of Psychology, Saybrook University.Cognitive Neurobiologist and originator of GWT Bernard J.Baars, Author of "ON CONSCIOUSNESS: Science & Subjectivity - Updated Works on Global Workspace Theory"Neuroscientist David Edelman, PhD, Visiting Scholar, Dept of Psychological & Brain Sciences, Dartmouth CollegeNeuroscientist Dr. Jay Giedd, Director of Child & Adolescent Psychiatry, Rady Children's Hospital; Professor of Psychiatry, UCSD School of MedicineNeuroscientist & Roboticist Jeffrey Krichmar, PHD, UC IrvineProfessional Magician Mark MittonEditor of "ON CONSCIOUSNESS" Natalie Geld, CEO & Founder, MedNeuro, Inc.Special Podcast VIP 40% Discount for Bernie Baars' new book, "On Consciousness: Science & Subjectivity - Updated Works on Global Workspace Theory" - GO TO: https://shop.thenautiluspress.com/collections/baars APPLY CODE AT CHECKOUT: PODCASTVIPVideo Podcast of Episode #5 - Part Four of NATURALIZING CONSCIOUSNESS: A Talk with Psychobiologist and Originator of Global Workspace Theory, Bernard Baars exploring conscious and unconscious brain events. 

In this webinar, Paul Gionfriddo, President of Mental Health America and Christine Moutier, MD, psychiatrist and Chief Medical Officer for American Foundation for Suicide Prevention discuss the impact of the novel coronavirus (COVID-19) pandemic on mental health with Stephen Murray, PharmD., MBA, Senior Medical Science Liaison for Otsuka Pharmaceutical Development & Commercialization, Inc. Our speakers will discuss the effects of social distancing, isolation, and stress of this crisis have on overall health and mental health. Dr. Moutier will share her expert advice on self-care tips for providers along with her perspectives on using digital technology to engage patients. Mr. Gionfriddo will discuss the effects of this crisis on individuals with underlying mental health conditions and share some useful tips for family engagement during this period of isolation. Paul Gionfriddo is the President and CEO of Mental Health America. He serves on the 12-member National Advisory Council to the Substance Abuse & Mental Health Services Administration (SAMHSA) Center for Mental Health Services. Mr. Gionfriddo also serves as a PsychU Stigma Section Advisor. Christine Mouthier, MD, is the Chief Medical Officer at the American Foundation for Suicide Prevention. Since earning her medical degree and training in psychiatry at the University of California San Diego, Dr. Mouthier has been a practicing psychiatrist, Professor and Dean in the UCSD School of Medicine, Medical Director of the inpatient psychiatric unit at the VA Medical Center in La Jolla. Stephen Murray, PharmD., MBA, Senior Medical Science Liaison for Otuska Pharmaceutical Development & Commercialization, Inc. Dr. Murray received his PharmD from the University of the Sciences in Philadelphia. Speakers are paid consultants for Otsuka Pharmaceutical Development & Commercialization, Inc.

“If not in the womb, at what point in life do we first have the sensation of being us? In terms of knowing that we’re an individual person... And where that line is crossed, including octopus or other animals, at what point in terms of our brain development are the brains capable of this sensation of being self aware?”Naturalizing Consciousness: Conversations on the Biology of Subjectivity - the Premiere Event for the New Podcast "On Consciousness with Bernard Baars" - and a Special Tribute to Nobel Laureate Gerald M. Edelman.Subscribe and Tune in!Dr. Jay Giedd Director, Child & Adolescent Psychiatry, Rady Children's Hospital; Professor of Psychiatry, UCSD School of Medicine Professor, Dept of Population, Family & Reproductive Health, Johns Hopkins Bloomberg School of Public Health.Former Chief, Section on Brain Imaging, Child Psychiatry Branch, National Institute of Mental Health (NIMH). Jay’s widely published research and expertise evaluates how the child's brain develops in health and illness, the factors that influence development and how to optimize treatments to take advantage of the child's changing brain.Jay and his award winning work were featured in the PBS 2 part series "Brains on Trial" hosted by Alan Alda. Video Link to Podcast Trailer: When are brains capable of this sensation of being self aware? Jay Giedd On Consciousness with Bernard Baars  

The engine of evolution is geared to overproduce and selectively eliminate. How do biological systems confront, adapt, and survive an ever-changing world?This is the central question that defined Charles Darwin’s scientific journey. In Episode #4 of NATURALIZING CONSCIOUSNESS - the premiere event for the new podcast "On Consciousness with Bernard Baars" - neuroscientists Bernard Baars, David Edelman, Jay Giedd, Jeff Krichmar, professional magician Mark Mitton, and editor Natalie Geld unpack the Theory of Neuronal Group Selection (TNGS) and make the case that this theory lays out tractable biological ‘first principles’ for building a brain that learns, remembers, and experiences.160 years after On the Origin of Species, Natural Selection provides a framework for understanding adaptation at many different scales of biological organization, from protein translation (e.g., ribosomes acting as mRNA message ‘filters’ which determine final protein products), to the immune response (i.e., ‘recognition’ of foreign agents or pathogens by antibodies), to organismal development (e.g., morphogenesis; embryogenesis, etc.), to the origin of species and dynamics of vast ecologies (e.g., rainforest canopies, grasslands, island biogeography, etc.).Could the very same Darwinian principles help explain how complex nervous systems adapt? It seems like a strange thought.BUT MORE THAN FORTY YEARS AGO, GERALD EDELMAN PROPOSED NEURAL DARWINISM, or the Theory of Neuronal Group Selection (TNGS), to account for the development and function of the human brain. Neural Darwinism proposes that the functional circuitry of the brain is determined by selective forces operating during development and throughout the life of an organism. It provides a robust biological framework for understanding brain function, including consciousness--the most complex and mysterious of all brain processes. In a nearly six decade long career, Gerald M. Edelman’s research spanned diverse areas of biological science, including immunology, developmental biology, and neuroscience. The common thread running through all of Dr. Edelman’s pursuits was an enduring interest in the relationship between biology and human experience. Neural Darwinism represents the culmination of his efforts to reconcile the two.SIMILARLY, COGNITIVE PSYCHOLOGIST BERNARD BAARS HAS SOUGHT TO LINK FUNDAMENTAL BRAIN PROCESSES and conscious human experience. His Global Workspace Theory and Edelman’s Neural Darwinism naturally complement one another. Both theories propose that the conscious brain supports numerous unconscious processes which together yield a single, coherent stream of experiences.Through recent neuroscientific advances, we have begun to lift the veil of mystery surrounding consciousness. In this open-minded discussion, our roundtable experts explore Neural Darwinism and Global Workspace in the context of these advances and make the case that together, these complementary theories provide a rich biological roadmap of subjective experience.COGNITIVE NEUROBIOLOGIST BERNARD J. BAARS, Author of "ON CONSCIOUSNESS: Science & Subjectivity - Updated Works on Global Workspace Theory"NEUROSCIENTIST DAVID EDELMAN, PHD, Visiting Scholar, Dept of Psychological & Brain Sciences, Dartmouth CollegeNEUROSCIENTIST DR. JAY GIEDD, Director of Child & Adolescent Psychiatry, Rady Children's Hospital; Professor of Psychiatry, UCSD School of MedicineNEUROSCIENTIST & ROBOTICIST JEFFREY KRICHMAR, PHD, UC IrvinePROFESSIONAL MAGICIAN MARK MITTONEDITOR OF "ON CONSCIOUSNESS" NATALIE GELD, CEO & Founder, MedNeuro, Inc.Special Podcast VIP 40% Discount for Bernie Baars' new book, "On Consciousness: Science & Subjectivity - Updated Works on Global Workspace Theory" - GO TO: https://shop.thenautiluspress.com/collections/baars APPLY CODE AT CHECKOUT: PODCASTVIPVideo Podcast of Episode #4 - Part Three of NATURALIZING CONSCIOUSNESS: Roundtable on Neural Darwinism and Global Workspace Theory  

In Part One of NATURALIZING CONSCIOUSNESS - the premiere event for the new podcast "On Consciousness with Bernard Baars" - neuroscientist David Edelman discusses his father, Nobel Laureate Gerald M. Edelman's life, reminisces about little known stories and milestones, and the professional artistry of GME's distinguished career and groundbreaking theories. 1st segment (:20 - 8:05) -- A Tribute to Nobel Laureate Gerald M. Edelman by Oliver Sacks and others, along with interviews with Gerald on Putting the Mind Back into Nature - in his own words.2nd segment (8:06 - 18:03) -- Neuroscientist David Edelman discusses his father, Nobel Laureate Gerald M. Edelman's life, reminisces about little known stories and milestones, and the professional artistry of GME's distinguished career and theories. In a nearly six decade long career, Gerald M. Edelman’s research spanned diverse areas of biological science, including immunology, developmental biology, and neuroscience. The common thread running through all of Dr. Edelman’s pursuits was an enduring interest in the relationship between biology and human experience. Neural Darwinism represents the culmination of his efforts to reconcile the two. NATURALIZING CONSCIOUSNESS: A Special Tribute to Nobel Laureate Gerald M. Edelman - Putting the Mind Back into Nature. Conversations on the Biology of Subjectivity with Psychobiologist Bernard J. Baars, Neuroscientists David Edelman, Jay Giedd, and Jeffrey Krichmar; and Professional Magician Mark Mitton. Moderator, Natalie Geld. COGNITIVE NEUROBIOLOGIST BERNARD J. BAARS, Author of "ON CONSCIOUSNESS: Science & Subjectivity - Updated Works on Global Workspace Theory"NEUROSCIENTIST DAVID EDELMAN, PHD, Visiting Scholar, Dept of Psychological & Brain Sciences, Dartmouth CollegeNEUROSCIENTIST DR. JAY GIEDD, Director of Child & Adolescent Psychiatry, Rady Children's Hospital; Professor of Psychiatry, UCSD School of MedicineNEUROSCIENTIST & ROBOTICIST JEFFREY KRICHMAR, PHD, UC IrvinePROFESSIONAL MAGICIAN MARK MITTONEDITOR OF "ON CONSCIOUSNESS" NATALIE GELD, CEO & Founder, MedNeuroSpecial Podcast VIP 40% Discount for Bernie Baars' new book, "On Consciousness: Science & Subjectivity - Updated Works on Global Workspace Theory" - GO TO: https://shop.thenautiluspress.com/collections/baars APPLY CODE AT CHECKOUT: PODCASTVIPVideo Podcast of Part 1 | Episode #2 - Naturalizing Consciousness: The professional artistry of Nobel Laureate Gerald Edelman illustrated in a special tribute by Gerald's son, neuroscientist and paleoanthropologist, David Edelman, PhD.

Are cites the world’s best hope for combating climate change? Many cities have committed to meeting the Paris Agreement goals. But are those targets translating to action on the ground?In this episode of Political Climate, we look at San Diego’s quest to achieve 100 percent carbon free electricity by 2035 and what other cities can learn from this experience. We recorded this episode at the UCSD School of Global Policy and Strategy, where we were joined by Cody Hooven, the first chief sustainability officer for the City of San Diego.We covered everything from how the city’s Republican mayor pushed through a bold climate action plan, to the community choice aggregation program San Diego is pursuing, to how cities are coping with the intersection of climate and equity issues. Before delving into the role that cities play in the fight against climate change, we touched on a few federal climate related news items. Here’s that conversation, we hope you enjoy.Recommended reading:Politico: Trump to nominate Dan Brouillette as Energy secretaryThe Hill: Senate Dems lose forced vote against EPA power plant ruleWSJ: City Pledges for ‘100% Renewable Energy’ Are 99% MisleadingSan Diego Tribune: San Diego City Council takes the leap into community choice energyGTM: San Diego Moves Ahead With 100% Clean Energy Community Choice ProgramPolitical Climate is produced in partnership with the USC Schwarzenegger Institute, and thanks to invaluable support from producer Victoria Simon.Subscribe to the Political Climate podcast via Apple Podcasts, Spotify, Stitcher, Google Podcasts, Overcast or any of these other services.

In Tiny Climate Challenge Episode 9 our Guest Expert Ashley Mazanec talks about the importance of EcoArts in addressing our climate crisis. Guest Expert Information Ashley Mazanec is an environmental policy and non-profit professional, eco-art educator, and eco musician committed to optimizing human and environmental health. As Assistant Executive Director of the San Diego Energy District, she is deeply invested in the future of clean energy in San Diego. Founding EcoArts Foundation in 2016 led to her current position in teaching and programming eco-art education at Del Sur Elementary. EcoArts Foundation's mission is to inspire the regeneration of Earth's ecosystems with creative media, events, and performance. Ashley has advanced this mission by producing: environmentally-themed music, an EcoArts TV production for the City of Palmdale, an educational eco art series generously funded by the Tommy Short Foundation, and the Let's Talk About the Weather podcast -- which explores ecological topics through the eyes of artists. She serves as a Sustainability Advisor for the City of Del Mar, and co-producer for ocean films with Spiral Pacific. Current board positions include the eco-village development nonprofit Local Earth, Citizens Coordinate for Century III, and the pioneer of San Diego's first EcoDistrict -- beautifulPB. Ashley is a partner and affiliated artist at the Climate Science Alliance. Ashley has been endowed with numerous awards from 2015 to 2017, including Global Policy and Strategy Fellowship, US-Israel Center for Innovation and Economic Sustainability Lead Fellowship, and Surfing Madonna Oceans Project Scholarship to the Artists and Climate Change Inaugural Incubator. She holds her Masters in International Environmental Policy from the UCSD School of Global Policy and Strategy, where she served as Net Impact UCSD Graduate Chapter President. Coverage on her activities can be found on KPBS, The Union Tribune Coastal, Voyager, podcast and radio interviews.  Contact Ashley Mazanec www.EcoArtsFoundation.org  Links mentioned UCSD - School of Global Policy & Strategy City of Encinitas Environmental Commission - Jim Wang Eco Sustainability Peeps  Climate Science Alliance Diane Burko Coral Reefs Encinitas Restaurants Healthy Creations Nectarine Grove Eve Encinitas Birdseye Kitchen Goodonya The Sandpiper Ocean Friendly Restaurants article Surfrider Ocean Friendly Restaurants  Other Mentions Let’s Talk About the Weather Ep. 24. Regan Rosburg: Breaching Grief, Melancholia and Mania with Biophilia  Artists and Climate Change Adidas (sustainable clothing and shoes) Contact Mayela Manasjan TinyClimate.com

Board-certified Obstetrician and Gynecologist Dr. Carolle Jen-Murat join Spiritual Teacher Maggie Kelly in an intriguing chat about what it looks like to be a medical intuitive and spiritual healer.  Raised in Haiti and from a family full of healers, Dr. Carolle discovered her gifts of being able to intuitively know what was causing your physical illness. Particularly, Dr. Carrolle is able to connect with adverse childhood experiences, emotional, verbal, physical or sexual trauma and assist you in healing those wounds.  Dr. Carolle centers her practice on the mind-body connection. She also volunteers her medical expertise in Haiti for those less fortunate, is a mentor and teacher at the UCSD School of Medicine in San Diego.  To connect with Dr. Carolle, please visit her website at www.drcarolle.com. If you'd like to connect with Maggie, please visit www.satsanghouse.net 

Jane Ferguson:                Hello and welcome to Getting Personal: Omics of the Heart, your podcast from Circulation: Genomic and Precision Medicine. I'm Jane Ferguson from Vanderbilt University Medical Center, and this is episode 27 from April 2019.                                            This month, I talk to Riyaz Patel, the first author on not one, but two articles published this issue, presenting analyses from the GENIUS-CHD consortium. But before we get to the interview, let's review what else was published this month.                                            First up, we have a paper from Tamiel Turley, Timothy Olson and colleagues from the Mayo Clinic, entitled Rare Missense Variants in TLN1 Are Associated With Familial and Sporadic Spontaneous Coronary Artery Dissection. In this study, the authors were interested in identifying novel susceptibility genes for spontaneous coronary artery dissection or SCAD, which predominantly affects young women who appeared otherwise healthy. They conducted whole exome sequencing in a family with three affected family members and found a rare missense variant in the TLN1, or talin 1, gene. This gene encodes the talin protein which is part of the integrin adhesion complex linking the actin cytoskeleton to the extracellular matrix. This gene and protein is highly expressed in coronary arteries. They went on to sequence additional sporadic cases of SCAD, and they found additional talin 1 variants in these individuals. While there was evidence for incomplete penetrance, these data implicate TLN1 as a disease-associated gene in both familial and sporadic SCAD.                                            The next paper comes from Miroslaw Lech, Jane Burns, and colleagues from UCSD School of Medicine and Momenta Pharmaceuticals and is entitled Circulating Markers of Inflammation Persist In Children And Adults With Giant Aneurysms After Kawasaki Disease. Kawasaki disease is the most common cause of acquired pediatric heart disease, but disease progression can vary a lot, and it's likely modulated by complex gene-environment interactions. Coronary artery aneurysms occur in about 25% of untreated patients, but early treatment with intravenous immunoglobulin or aspirin reduces the risk for these aneurysms to 5%, suggesting an important role for inflammation. In this study, the authors applied shotgun proteomics, transcriptomics, and glycomics on eight pediatric Kawasaki disease patients at the acute, subacute, and convalescent time points. They identified inflammatory profiles characterizing acute disease which resolved during the subacute and convalescent time points, except for in the patients who went on to develop giant coronary artery aneurysms. They went on to carry out proteomics on nine Kawasaki disease adults with giant coronary artery aneurysms and matched healthy controls, and they confirmed the inflammatory profiles in the adult samples.                                            In particular, calprotectin, which is composed of S100A8 and S100A9, was elevated in the plasma of patients with CAA, an association they confirmed in additional samples of pediatric and adult Kawasaki disease patients and healthy controls. These data suggest that calprotectin may serve as a biomarker of ongoing inflammation in Kawasaki disease patients following acute illness, and may be able to identify individuals at increased risk of aneurysms.                                            Next up, we have a research letter, Heart BioPortal: An Internet-of-Omics for Human Cardiovascular Disease Data, from Bohdan Khomtchouk, Tim Assimes, and colleagues from Stanford University. They had noticed that, in contrast to the field of cancer research, there were no open access platforms for cardiovascular disease data that offered users the ability to visualize and explore high quality data. They set out to fix this and developed the Heart BioPortal, which is accessible at www.heartbioportal.com. This portal allows the user to integrate existing CDD related omics data sets in real time and provides intuitive visualization and analyses in addition to data downloads. The primary goals are to support gene, disease, or variant-specific request, and to visualize the search results in a multi-omics context.                                            They currently collate gene expression, genetic association, and ancestry allele frequency information for over 23,000 human genes and almost 6,000 variants across 12 broadly defined cardiovascular diseases spanning 199 different research studies. And this is just the start, they're hoping to add more studies, more data, and functionality for querying CDD drug targets, along with lots more. This is a really great resource which will no doubt be of real value to the community. I urge you to go online, check it out, put in your favorite gene, and see what you find.                                            Riyaz Patel, Folkert Asselbergs, and many, many collaborators published Subsequent Event Risk in Individuals With Established Coronary Heart Disease: Design and Rationale of the GENIUS-CHD Consortium and Association of Chromosome 9p21 with Subsequent Coronary Heart Disease Events: A GENIUS-CHD Study Of Individual Participant Data. These papers present the design of the genetics of subsequent coronary heart disease, or GENIUS-CHD consortium, which was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events in individuals with established CHD. The consortium currently includes 57 studies from 18 countries, recruiting over 185,000 participants with either acute coronary syndrome, stable CHD, or a mixture of both at baseline. All studies collected biological samples and followed up study participants prospectively for subsequent events. Enrollment into the individual studies took place between 1985 to the present day, and the duration of follow-up ranges from nine months to 15 years. Participants have mostly European ancestry, are more likely to be male, and were recruited between 40 to 75 years of age.                                            In their first analysis using these data, they investigated whether the established 9p21 locus associated with subsequent events in individuals with established coronary heart disease. Confirming previous smaller studies, they showed that while genotype at 9p21 is associated with coronary disease when compared to healthy controls, 9p21 genotype is not associated with a risk of future events in people who already have coronary disease. Dr. Patel joins me to tell me more about the GENIUS-CHD consortium and the analyses described in these papers.                                            Today, I'm joined by Dr. Riyaz Patel, who's an associate professor at University College London and a cardiologist at the Barts Heart Centre in London. Dr. Patel, thank you so much for joining me. Dr. Riyaz Patel:                Pleasure to be on, thanks. Jane Ferguson:                So, as we're going to discuss, you are the lead author on two back-to-back publications that were published in Circ Gen this month exploring genetic predictors of coronary heart disease as part of the GENIUS-CHD consortium. Before we delve fully into them, could you tell us a little bit about your background and how you got into this research field? Dr. Riyaz Patel:                Yes. I'm an academic cardiologist, as you know, and I first got into genetics of coronary disease about 12-13 years ago, now, around the time that genome wide association studies were about to take off, or were taking off. I studied, I worked at Emory University, in fact, in Atlanta, in the US. We had a very big cohort of patients who had coronary disease, who were undergoing coronary angiography. At that time, we were doing quite a lot of genetic association studies and biomarker work in patients with heart disease. One of the key problems we often encountered was sort of looking for replication cohorts and trying to do things at a bigger scale than what we had available. So that kind of really was the initial driver for trying to bring together a bigger collaboration to take that sort of work to the next level. Jane Ferguson:                It sounds like you've got valuable expertise, because looking at the author list for these papers, I think it's one of the longest author lists I've ever seen. It's a huge endeavor. I'd love to hear more about how that got started and how you managed to build this consortium, and you know, and tell us what the consortium actually is. Dr. Riyaz Patel:                Yeah, it's been a labor of love. And essentially, I started when I returned back to the UK and we were looking to develop this further. We had already collaborated with several colleagues in the US and abroad from my time at Emory. So, we pulled together a small group of people who we were already working together with and then we did predicts of systematic searches of literature to identify cohorts who were also doing similar things. Again, investigating people with heart disease and looking at subsequent event risk. So, we did that and then we systematically approached, very much, as many people as we could find and over the course of the last, maybe 3 or 4 years, we've brought together a small community of collaborators around the world, and as you rightly said, it's a very long list. In total, we're counting around 180 or so investigators. But, in a way, that also speaks to how this consortium is not just a collection of studies. It is a collection of people and a lot of expertise was brought to the table because of that. People have been thinking about these questions for many, many years and this platform essentially is an opportunity for everyone to share that knowledge. Dr. Riyaz Patel:                So that's kind of how the consortium started and is being pulled together. We operate on a sort of loose memorandum of understanding where every member of the consortium is free to participate in studies as they wish. We run analysis in a federated way which means that [inaudible 00:10:50] scripts are shared and people standardize their data and then they run analyses locally and they only share summary level data so that obviously overcomes the big governance hurdle. So, that's pretty much how the consortium works at moment. Jane Ferguson:                Yeah. I'm sure there was probably a lot of challenges along the way in figuring this out and getting scripts that work for everybody, dealing with all the people, so how do you do this? Do you have regular phone calls with 180 people on it? Do you have lots and lots of emails? Dr. Riyaz Patel:                (laughs) Jane Ferguson:                How's it actually working? Dr. Riyaz Patel:                So, we have a steering committee which is represented by at least one person from each study. So, that limits the number of people down to about, a more manageable number, about 50 or 60. And we do have regular teleconferences, particularly in the early days when we were still pulling everything together. Now, we try and meet at least once a year, if not twice at year at the major conferences, at the European Site of Cardiology and one of the big American meetings, ACC or AHA, so that's usually a good face to face meeting that we have with everyone and then as with all consortia, we have regular email lists and contact through that means. Jane Ferguson:                So, now that you've got everybody together, you have over 185,000 participants as part of this from 18 different countries. So, how have you been able to use all of these different data and harmonize the different phenotypes and sort of put everything together to actually run the analyses. Dr. Riyaz Patel:                The way we started off is by asking everyone to share almost an inventory of what they have collected. We then sought to try and standardize all of the core variables: age, sex, smoking and so forth. Once we were happy about the key variables had been standardized, units were the same and so forth, we then created, effectively a GENIUS-CHD data set that each cohort had curated. So, this was the main way of harmonizing the data set. Now, obviously, there are a lot of other differences between each of these studies. So, we have within the consortium a combination of different studies. We have randomized clinical trials, we have cohort studies, we have nested cohorts from larger population studies and we try and, in all of the analyses, we have pre specified subgroup analyses to try and look out and check for any heterogeneity that is introduced because of all of this. But the biggest, sort of, difference that we have factored in is that each of these studies collects patients with different types of coronary heart disease. Dr. Riyaz Patel:                So, there are about ... 40% or so are acute coronary syndrome recruited patients, where these people are recruited at the time or after their acute event. And a similar proportion are recruited when they're much more stable. So, in all of our analyses we do try and factor in the differences in terms of the type of CHD patients are enrolled with but everything else, as best as we can, we have tried to standardize including all of the outcomes. So, for example, we share the ICD codes that would define a particular type of outcome across all the different cohorts, so even if you're in a different country, they will generally be reasonably well standardized. Jane Ferguson:                Mm-hmm (affirmative), yeah, yeah. I think it's important and I can see the pros and the cons, you know, you have more diversity and you're representing a broader spectrum of disease by including everybody but then, of course, it's hard to figure it out, but I'd say it gives you a lot of versatility with the types of analyses you can do. Jane Ferguson:                As we mentioned, there's two papers so people can go online and read those two papers. And the first one, is sort of the design and goes really into detail of how you guys set this up and I think is a really nice, sort of, example of, if anybody else was trying to (laughs) do something like this, of how to follow it. But then you also did, sort of, an initial analysis, right, to show what this consortium can actually do. I looked at 9p21, so I'd love to hear more about those analyses. Dr. Riyaz Patel:                Yeah, so 9p21 is one of the most reproduced variants with coronary disease across the world. And it's remarkable how well replicated it's been in all sorts of settings in different countries. But the key thing is that it's been associated mostly in case controlled studies or in first event type of studies. And when we looked at this question some years ago now, at whether a variation of chromosome 9p21 is also associated with subsequent events, IE., we could test in people who've already had a heart attack or coronary disease, does it predict a worse outcome for them. We found that it hadn't. Dr. Riyaz Patel:                [inaudible 00:16:06] was in the literature metro analyses and, sort of, all the caveats that come with that. So, we thought that as a feasibility analysis within the consortium, "why don't we also look at 9p21," which we did and this time around, we were able to identify that 93,000 people with coronary heart disease who had our primary endpoint of coronary heart disease death or MI subsequent to other index events. Again, we confirmed our previously met analyses findings that in this particular setting, 9p21 doesn't seem to associate with risk of subsequent events. And that sort of fits with our understanding of 9p21 so far. And interestingly, in one of our analyses, we identified that it does associate with risk of repeat revascularization. And from what we know about 9p21 so far, it seems to associate with risk of atheroma development or progression as opposed to perhaps plaque vulnerability or rupture which might give you an acute coronary event. Dr. Riyaz Patel:                So, it's been a good example, I think, and really an illustration of how this consortium can work at scale. We have a lot of flexibility in terms of different subgroups that we can look at. And we really drilled down in this paper at all the possible reasons why a neutral finding may have occurred. We've looked at selection bias, we've looked at all the different subgroups which was can do because of the scale of the analysis. So, yeah, so that's kind ... it's really, the findings are not particularly novel in their own right but it is a very good example of feasibility of a consortium. Jane Ferguson:                Yeah, I agree. Because it is, so often, if you get, sort of, a negative finding, you keep wondering, "Well, was it just the power? Do we not ... are we not able to find it?" But, I think, with the scale that you have, you're really able to drill down and say, "Look, we really think there's nothing here. It's a true negative finding." You know, 9p21 is not associated with subsequent events, although, I think the revascularization is interesting and that can, sort of, inform, I guess, more basic research into the the mechanisms of 9p21. Dr. Riyaz Patel:                Exactly. Exactly. Jane Ferguson:                So, what's next? I'm sure there's a lot more papers and analyses that are, sort of, to come out of this. So, can you give us, sort of, a sneak peek of what you're working on now? Dr. Riyaz Patel:                Yeah, so, like with 9p21, we did have a selection of variants to answer important questions. So, for example, we were looking at the role of PCSK9 variation to try and see how that relates in this particular setting, given that trials have already reported on the effective drug. And similarly, we're also looking at interlinking six receptor blockade as a, sort of, similar sort of [inaudible 00:19:11] randomization study to look at the validity of a drug target in a secondary prevention setting. Dr. Riyaz Patel:                Beyond that, we are looking at genome wide association studies and, hopefully, once that is done, the consortium will be in a position to do lots of quick look-ups or all sorts of different questions in genetic variation to inform drug target analyses. So, those are immediate priorities, but we are also, in parallel, looking at non-genetic analyses, so, once again, there are lots of standard clinical risk factors that we need to explore a bit more thoroughly in this setting. So as you're aware, there are various paradoxes that keep creeping up in studies where patients have coronary heart disease already, so the obesity paradox is a good example. And what we're hoping to do, is we're hoping to drill down into many of these observational findings in this particular setting, which hasn't really been done, simply again, because the lack of available resources of anything at this scale. Jane Ferguson:                It's exciting and it sounds like you have a really powerful set of different data sets to be able to ask a lot of interesting questions. So, I'm excited to see what's gonna come out next. Dr. Riyaz Patel:                The other key thing we're working on is also about risk prediction. So, again, one of the things we're missing in the clinical community is good risk prediction tools for subsequent event risk among patients with heart disease. We are working with various colleagues to try and develop better risk prediction algorithms for people who've survived coronary event or have coronary disease. Jane Ferguson:                Alright, that's really interesting and that feeds in really nicely then to, sort of, the precision medicine approach. Well, congratulations on building this. I think that's a huge effort in itself and then also in these two papers that were published this month. I think it's really, really, really great work. Dr. Riyaz Patel:                Well thank you. And a key message here is that we want to build and expand this community of investigators around the world who are looking at risk question because individually, I think, we've all struggled with various, sort of, issues. But collectively, I think we have so much more potential to really address some big questions. And the consortium, as I mentioned, is not just investigator led in terms of what we're doing. We're also very open to collaboration and for people wishing to replicate their own findings and are looking for similar cohorts or larger scale validation opportunities so that is also another key advantage in benefit or risk consortium. Jane Ferguson:                Well, that's wonderful. So, if anyone has either data sets that they want to contribute, are you still, sort of, accepting new investigators? Dr. Riyaz Patel:                Absolutely. Very much so. I mean, in the paper, we do mention that we are limited, particularly in terms of cohorts that are enriched for female patients as well as cohorts enriched for patients who are non-Caucasian, in terms of ethnicity. Because, again, those are important patient groups that we need to address. But, generally speaking, we are absolutely open to including anyone who's interested and who meets the inclusion criteria which is collecting people with coronary heart disease, have got genotyping or examples stored for future analysis and have prospective outcomes connected. Jane Ferguson:                And is there a minimum size of sample that somebody needs to participate? Dr. Riyaz Patel:                Ideally, we'd like to, sort of, set that level at about 1,000 recruited patients. But again, if someone has a very deeply phenotyped cohort and that are interested, we'd be more than happy to discuss that and take that to the steering group. Jane Ferguson:                Okay, wonderful. So, people can just email you if they wanna contact- Dr. Riyaz Patel:                Absolutely. Jane Ferguson:                You any further. Dr. Riyaz Patel:                We also have a website, which is for the consortium, which also has contact details on there. Jane Ferguson:                Okay, perfect. Alright, so let me see. Your email is riyaz.patel@ucl.ac.uk- Dr. Riyaz Patel:                Right. Jane Ferguson:                And then the website for the consortium? Dr. Riyaz Patel:                Www.genius-chd.org Jane Ferguson:                Okay. Perfect. Thank you. So, any listeners that are interested, we'll urge them to either go to the website, read some more, go read the papers, email you directly to talk more. Thank you so much for joining me and for talking about this work. Dr. Riyaz Patel:                Thank you for having me. Jane Ferguson:                That's it for April. Come back in May for the next issue. And thank you for listening.                                            This podcast was brought to you by Circulation: Genomic and Precision Medicine and the American Heart Association Council on Genomic Precision Medicine. This program is copyright American Heart Association 2019.  

The psychology of diabetes is an important topic and support in this area may be difficult to come by; but we've found a tremendous resource. On today's show we have Dr. Mark Heyman. Mark is a PhD in Clinical Psychology and he completed clinical training at UCSD School of Medicine. He is a Certified Diabetes Educator and the Director for the Center for Diabetes and Mental Health in San Diego, CA, which is a specialty center focused on the psychosocial, emotional and behavioral aspects of diabetes. Mark also sits on the Boards of a number of diabetes non-profit organizations. And while his background is definitely impressive, what I love about him is that he not only speaks from a standpoint of an academic, he's also been living with the realities of type 1 since 1999. So what you'll hear from Mark is not only the words of a psychologist, but also his deep understanding and practical knowledge that's derived from his personal experiences. Our conversation begins with Mark's entry into a world with type 1 when he was a student at UCLA. He talks about how the physician who initially handed him the diagnoses set the stage for Mark to develop a ‘no limitations' mindset when it came to his diabetes. Mark shares how important that was in shaping his optimistic mindset. We then go on to talk about the very heavy topic of depression. Mark also shares a wealth of knowledge on other issues we might face including anxiety, burnout, and how to change health behaviors that simply don't work for us any longer. We finish up the show with Mark's thoughts on why he believes living with diabetes can actually be a positive in our lives, as well as why he thinks  humor and laughter serve as a critical component in our ability to lead a healthy life.

In our season finale, Christy talks with psychologist Joy Jacobs about her history of anorexia and binge eating, the role of readiness and meal planning in her recovery, the science of eating disorders, and lots more!    Dr. Joy Jacobs is a clinical psychologist, assistant clinical professor at UCSD School of Medicine, and published author who provides individual, family and group therapy for adults, adolescents, and children with eating disorders (including anorexia nervosa, bulimia nervosa, and binge eating disorder) and weight management concerns. She has trained in multiple treatment modalities, including Maudsley family-based therapy, dialectical behavioral therapy, cognitive behavioral therapy, and interpersonal psychotherapy. Dr. Jacobs is one of the few officially certified providers of Maudsley family-based treatment nationwide and internationally. Find her online at DrJoyJacobs.com. To learn more about Food Psych and our guest, visit christyharrison.com/foodpsych Ready to make peace with food? Join Christy's intuitive eating online course!  How healthy is your relationship with food? Take the quiz and get free resources at christyharrison.com/quiz!

Cedric F. Garland, Dr PH FACE, UCSD School of Medicine, identifies cancers that have lower incidence at the equator and discusses the characteristics of the human photoprotective response. Series: "Vitamin D for Public Health - Integrating Sunshine, Supplements and Measurement for Optimal Health 2014" [Health and Medicine] [Professional Medical Education] [Show ID: 29078]

Cedric F. Garland, Dr PH FACE, UCSD School of Medicine, identifies cancers that have lower incidence at the equator and discusses the characteristics of the human photoprotective response. Series: "Vitamin D for Public Health - Integrating Sunshine, Supplements and Measurement for Optimal Health 2014" [Health and Medicine] [Professional Medical Education] [Show ID: 29078]

Dr. Nathan E. Lewis of the Novo Nordisk Foundation Center for Biosustainability at UCSD School of Medicine speaks to CHI on November 3, 2014. Dr. Lewis will be a speaker during the Recombinant Protein Expression and Production and CHO Cells conferences at PepTalk, January 19-23, 2015 in San Diego, CA. Topics include the promise and challenges of using Chinese hamster ovary cells for enhancing recombinant protein expression and production, the creation of computational models by integrating metabolism glycosylation and the protein secretion pathway, the Novo Nordisk partnership with University of California, San Diego and more.

The 2014 Keeling Lecture features UCSD School of International Relations and Pacific Studies Professor David Victor, an internationally recognized leader in research on energy and climate change policy. He is the Director of the school’s new Laboratory on International Law and Regulation, and author of numerous books including his most recent, “Global Warming Gridlock: Creating More Effective Strategies for Protecting the Planet.” Series: "Jeffrey B. Graham Perspectives on Ocean Science Lecture Series" [Public Affairs] [Science] [Show ID: 27846]

The 2014 Keeling Lecture features UCSD School of International Relations and Pacific Studies Professor David Victor, an internationally recognized leader in research on energy and climate change policy. He is the Director of the school’s new Laboratory on International Law and Regulation, and author of numerous books including his most recent, “Global Warming Gridlock: Creating More Effective Strategies for Protecting the Planet.” Series: "Jeffrey B. Graham Perspectives on Ocean Science Lecture Series" [Public Affairs] [Science] [Show ID: 27846]