Podcasts about european prospective investigation

This week we talk about all things bone health on the podcast.  From what foods to eat to improve bone health and reduce the risk of hip fractures, to the calcium 'thieves' hidden in our diets, to exercise and much much more.  Dr. Rajiv Bajekal (MS, FRCS Orth., MCh Orth., IBLM) is a Consultant Spinal Surgeon based in London with over 35 years of expertise in Orthopaedics and Spinal Surgery. Specialising in the lumbar spine, he has a deep focus on managing conditions such as sciatica, low back pain, spinal stenosis, osteoporotic fractures, and infections. Dr. Bajekal prioritizes holistic and often non-surgical solutions for patients in severe pain, combining his surgical knowledge with his expertise as a Board-Certified Lifestyle Medicine Practitioner. A strong advocate for lifestyle medicine, Dr. Bajekal has personally experienced the transformative benefits of a whole-food, plant-based diet and incorporates these principles into his practice.  Dr. Bajekal has contributed to the UK's first plant-based nutrition course at Winchester University, where he developed a module on bone health and osteoporosis. He also co-authored a chapter on bone health in the academic book Plant-Based Nutrition in Clinical Practice. Passionate about education, he is known for making complex spinal topics accessible and engaging. For more information, visit www.rajivbajekal.com and follow him on Instagram @drrajivbajekal Relevant studies:1. Tong, T.Y.N., Appleby, P.N., Armstrong, M.E.G. et al. Vegetarian and vegan diets and risks of total and site-specific fractures: results from the prospective EPIC-Oxford study. BMC Med 18, 353 (2020). https://doi.org/10.1186/s12916-020-01815-3 2.     Gómez-Cabello A, Ara I, González-Agüero A, Casajús JA, Vicente-Rodríguez G. Effects of training on bone mass in older adults: a systematic review. Sports Med. 2012;1;42(4):301-25. 3.  Messina M. Soy and Health Update: Evaluation of the Clinical and Epidemiologic Literature. Nutrients. 2016;8(12):754. Published 2016 Nov 24. doi:10.3390/nu8120754 4.  Sahni S, Mangano KM, McLean RR, Hannan MT, Kiel DP. Dietary Approaches for Bone Health: Lessons from the Framingham Osteoporosis Study. Curr Osteoporos Rep. 2015;13(4):245-255. doi:10.1007/s11914-015-0272-1 5.  Qiu, Rui & Cao, Wen-ting & Tian, Hui-yuan & He, Juan & Chen, Gengdong & Chen, Yu Ming. (2017). Greater Intake of Fruit and Vegetables Is Associated with Greater Bone Mineral Density and Lower Osteoporosis Risk in Middle-Aged and Elderly Adults. PLOS ONE. 12. e0168906. 10.1371/journal.pone.0168906.6.  Wallace TC. Dried Plums, Prunes and Bone Health: A Comprehensive Review. Nutrients. 2017 Apr 19;9(4):401. doi: 10.3390/nu9040401. PMID: 28422064; PMCID: PMC5409740.7.  Sahni S, Mangano KM, McLean RR, Hannan MT, Kiel DP. Dietary Approaches for Bone Health: Lessons from the Framingham Osteoporosis Study. Curr Osteoporos Rep. 2015 Aug;13(4):245-55. doi: 10.1007/s11914-015-0272-1. PMID: 26045228; PMCID: PMC4928581.8.  Laird E, Ward M, McSorley E, Strain JJ, Wallace J. Vitamin D and bone health: potential mechanisms. Nutrients. 2010 Jul;2(7):693-724. doi: 10.3390/nu2070693. Epub 2010 Jul 5. PMID: 22254049; PMCID: PMC3257679.9.  Bolland M J, Avenell A, Baron J A, Grey A, MacLennan G S, Gamble G D et al. Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis BMJ 2010; 341 :c3691 doi:10.1136/bmj.c369110.  Bolland MJ, Grey A, Avenell A, Gamble GD, Reid IR. Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women's Health Initiative limited access dataset and meta-analysis. BMJ. 2011 Apr 19;342:d2040. doi: 10.1136/bmj.d2040. PMID: 21505219; PMCID: PMC3079822.11.  Li K, Kaaks R, Linseisen J, et alAssociations of dietary calcium intake and calcium supplementation with myocardial infarction and stroke risk and overall cardiovascular mortality in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition study (EPIC-Heidelberg)Heart 2012;98:920-92512.  Price CT, Langford JR, Liporace FA. Essential Nutrients for Bone Health and a Review of their Availability in the Average North American Diet. Open Orthop J. 2012;6:143-149. doi:10.2174/187432500120601014313.  Bawa S. The significance of soy protein and soy bioactive compounds in the prophylaxis and treatment of osteoporosis. J Osteoporos. 2010 Mar 8;2010:891058. doi: 10.4061/2010/891058. PMID: 20981338; PMCID: PMC295724114.  Zhang X, Shu X, Li H, et al. Prospective Cohort Study of Soy Food Consumption and Risk of Bone Fracture Among Postmenopausal Women. Arch Intern Med. 2005;165(16):1890–1895. doi:10.1001/archinte.165.16.189015.  Tucker KL, Morita K, Qiao N, Hannan MT, Cupples LA, Kiel DP. Colas, but not other carbonated beverages, are associated with low bone mineral density in older women: The Framingham Osteoporosis Study. Am J Clin Nutr. 2006 Oct;84(4):936-42. doi: 10.1093/ajcn/84.4.936. PMID: 17023723. 16.  Chen L, Liu R, Zhao Y, Shi Z. High Consumption of Soft Drinks Is Associated with an Increased Risk of Fracture: A 7-Year Follow-Up Study. Nutrients. 2020;12(2):530. Published 2020 Feb 19. doi:10.3390/nu1202053017.  Cheraghi Z, Doosti-Irani A, Almasi-Hashiani A, Baigi V, Mansournia N, Etminan M, Mansournia MA. The effect of alcohol on osteoporosis: A systematic review and meta-analysis. Drug Alcohol Depend. 2019 Apr 1;197:197-202. doi:10.1016/j.drugalcdep.2019.01.025. Epub 2019 Feb 27. PMID: 30844616.18.  Chang HC, Hsieh CF, Lin YC, Tantoh DM, Ko PC, Kung YY, Wang MC, Hsu SY, Liaw YC, Liaw YP. Does coffee drinking have beneficial effects on bone health of Taiwanese adults? A longitudinal study. BMC Public Health. 2018 Nov 20;18(1):1273. doi: 10.1186/s12889-018-6168-0. PMID: 30453911; PMCID: PMC6245613.19.  Benedetti, Maria Grazia & Furlini, Giulia & Zati, Alessandro & Letizia Mauro, Giulia. (2018). The Effectiveness of Physical Exercise on Bone Density in Osteoporotic Patients. BioMed Research International. 2018. 1-10. 10.1155/2018/4840531.

ReferencesChitnis MM, Yuen JS, Protheroe AS, et al. The type 1 insulin-like growth factor receptor pathway.Clin Cancer Res 2008,14:6364-6370.Werner H, Bruchim I. The insulin-like growth factor-I receptor as an oncogene.Arch Physiol Biochem 2009, 115:58-71.Davies M, Gupta S, Goldspink G, Winslet M. The insulin-like growth factor system and colorectal cancer: clinical and experimental evidence.Int J Colorectal Dis 2006, 21:201-208.Sandhu MS, Dunger DB, Giovannucci EL. Insulin, insulin-like growth factor-I (IGF-I), IGF binding proteins, their biologic interactions, and colorectal cancer.J Natl Cancer Inst 2002, 94:972-980.Kaaks R. Nutrition, insulin, IGF-1 metabolism and cancer risk: a summary of epidemiological evidence.Novartis Found Symp 2004, 262:247-260; discussion 260-268.Lamberts SW, van den Beld AW, van der Lely AJ. The endocrinology of aging.Science 1997, 278:419-424.Doi T, Shimada H, Makizako H, et al. Association of insulin-like growth factor-1 with mild cognitive impairment and slow gait speed.Neurobiol Aging 2015, 36:942-947.Calvo D, Gunstad J, Miller LA, et al. Higher serum insulin-like growth factor-1 is associated with better cognitive performance in persons with mild cognitive impairment.Psychogeriatrics 2013, 13:170-174.Thissen JP, Ketelslegers JM, Underwood LE. Nutritional regulation of the insulin-like growth factors.Endocr Rev 1994,15:80-101.Clemmons DR, Seek MM, Underwood LE. Supplemental essential amino acids augment the somatomedin-C/insulin-like growth factor I response to refeeding after fasting.Metabolism 1985, 34:391-395.Runchey SS, Pollak MN, Valsta LM, et al. Glycemic load effect on fasting and post-prandial serum glucose, insulin, IGF-1 and IGFBP-3 in a randomized, controlled feeding study.Eur J Clin Nutr 2012, 66:1146-1152.Brand-Miller JC, Liu V, Petocz P, Baxter RC. The glycemic index of foods influences postprandial insulin-like growth factor-binding protein responses in lean young subjects.Am J Clin Nutr 2005, 82:350-354.Biddinger SB, Ludwig DS. The insulin-like growth factor axis: a potential link between glycemic index and cancer.Am J Clin Nutr 2005, 82:277-278.Burgers AM, Biermasz NR, Schoones JW, et al. Meta-analysis and dose-response metaregression: circulating insulin-like growth factor I (IGF-I) and mortality.J Clin Endocrinol Metab 2011, 96:2912-2920.Ranke MB, Osterziel KJ, Schweizer R, et al. Reference levels of insulin-like growth factor I in the serum of healthy adults: comparison of four immunoassays.Clin Chem Lab Med 2003, 41:1329-1334.Bidlingmaier M, Friedrich N, Emeny RT, et al. Reference intervals for insulin-like growth factor-1 (igf-i) from birth to senescence: results from a multicenter study using a new automated chemiluminescence IGF-I immunoassay conforming to recent international recommendations.J Clin Endocrinol Metab 2014, 99:1712-1721.Brabant G, von zur Muhlen A, Wuster C, et al. Serum insulin-like growth factor I reference values for an automated chemiluminescence immunoassay system: results from a multicenter study.Horm Res 2003, 60:53-60.Crowe FL, Key TJ, Allen NE, et al. The association between diet and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in the European Prospective Investigation into Cancer and Nutrition.Cancer Epidemiol Biomarkers Prev 2009,18:1333-1340.Fontana L, Klein S, Holloszy JO. Long-term low-protein, low-calorie diet and endurance exercise modulate metabolic factors associated with cancer risk.Am J Clin Nutr 2006, 84:1456-1462.Fontana L, Weiss EP, Villareal DT, et al. Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans.Aging Cell 2008, 7:681-687.Friedrich N, Haring R, Nauck M, et al. Mortality and serum insulin-like growth factor (IGF)-I and IGF binding protein 3 concentrations.J Clin Endocrinol Metab 2009, 94:1732-1739.Carlzon D, Svensson J, Petzold M, et al. Both low and high serum IGF-1 levels associate with increased risk of cardiovascular events in elderly men.J Clin Endocrinol Metab 2014, 99:E2308-2316.Svensson J, Carlzon D, Petzold M, et al. Both low and high serum IGF-I levels associate with cancer mortality in older men.J Clin Endocrinol Metab 2012, 97:4623-4630. .van Bunderen CC, van Nieuwpoort IC, van Schoor NM, et al. The Association of Serum Insulin-Like Growth Factor-I with Mortality, Cardiovascular Disease, and Cancer in the Elderly: A Population-Based Study.J Clin Endocrinol Metab 2010.Arai Y, Takayama M, Gondo Y, et al. Adipose endocrine function, insulin-like growth factor-1 axis, and exceptional survival beyond 100 years of age.J Gerontol A Biol Sci Med Sci 2008, 63:1209-1218.Johnsen SP, Hundborg HH, Sorensen HT, et al. Insulin-like growth factor (IGF) I, -II, and IGF binding protein-3 and risk of ischemic stroke.J Clin Endocrinol Metab 2005, 90:5937-5941.Hankinson SE, Willett WC, Colditz GA, et al. Circulating concentrations of insulin-like growth factor-I and risk of breast cancer.Lancet 1998, 351:1393-1396.Chan JM, Stampfer MJ, Giovannucci E, et al. Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study.Science 1998, 279:563-566.

Welcome to the Olink® Proteomics in Proximity podcast!   Below are some useful resources from this episode:  Published study of primary focusKoprulu M, Carrasco-Zanini J, Wheeler E, Lockhart S, Kerrison ND, Wareham NJ, Pietzner M, Langenberg C. Proteogenomic links to human metabolic diseases. Nat Metab. 2023 Mar;5(3):516-528. doi: 10.1038/s42255-023-00753-7. Epub 2023 Feb 23. Erratum in: Nat Metab. 2023 Mar 19;: PMID: 36823471; PMCID: PMC7614946. https://pubmed.ncbi.nlm.nih.gov/36823471/ Laboratory, first author, and corresponding author of the study·         Public Health University Research Institute (PHURI), a multidisciplinary research center to drive personalized healthcare: https://www.qmul.ac.uk/phuri/about/·         Mine Koprulu (first author), PhD student, University of Cambridge: https://www.linkedin.com/in/mine-koprulu-497659b9/  ·         Dr. Claudia Langenberg (corresponding author); Director of PHURI, Queen Mary, University of London; Professor of Computational Medicine, Berlin Institute of Health at Charité: https://www.qmul.ac.uk/phuri/our-people/professor-claudia-langenberg/  Olink tools and software·         Olink® Explore 3072, the platform that measured proteins in this study with a next-generation sequencing (NGS) readout: https://olink.com/products-services/explore/ UK Biobank Pharma Proteomics Project (UKB-PPP), one of the world's largest scientific studies of blood protein biomarkers conducted to date, https://www.ukbiobank.ac.uk/learn-more-about-uk-biobank/news/uk-biobank-launches-one-of-the-largest-scientific-studies  Genotype-Tissue Expression (GTEx) project, a biobank and open-access database to study tissue-specific gene expression and regulation: https://www.gtexportal.org/home/ European Prospective Investigation into Cancer (EPIC)-Norfolk study, a prospective cohort of middle-aged individuals from Eastern England: https://www.epic-norfolk.org.uk/  Genome Aggregation Database (gnomAD), the largest publicly available collection of population variation from harmonized exome and genome sequencing data: https://gnomad.broadinstitute.org/   Would you like to subscribe to the podcast on your favorite player or app? You can do so here: Apple Podcasts: https://apple.co/3T0YbSm Spotify Podcasts: https://open.spotify.com/show/2sZ2wxO... Google Podcasts: https://podcasts.google.com/feed/aHR0... Amazon Music: https://music.amazon.com/podcasts/d97... Podcast Addict: https://podcastaddict.com/podcast/409... Deezer: https://www.deezer.com/show/5178787 Player FM: https://player.fm/series/series-3396598  In case you were wondering, Proteomics in Proximity refers to the principle underlying Olink technology called the Proximity Extension Assay (PEA). More information about the assay and how it works can be found here: https://bit.ly/3Rt7YiY  For any questions regarding information Olink Proteomics, please email us at info@olink.com or visit our website: https://www.olink.com/ WHAT IS PROTEOMICS IN PROXIMITY?Proteomics in Proximity discusses the intersection of proteomics with genomics for drug target discovery, the application of proteomics to reveal disease biomarkers, and current trends in using proteomics to unlock biological mechanisms. Co-hosted by Olink's Cindy Lawley and Sarantis Chlamydas.

Lege Sjur Even Aunmo er opptatt av å følge med på forskning. I denne episoden forteller han om problemene med å leve av planter. Planter har nemlig forsvarsmekanismer mot å bli spist. De kan dessuten stjele mineraler, trigge immunsystemet, tilføre tungmetall og gi næring til kreft. Selv foretrekker han et kosthold bestående utelukkende av animalske produkter. Han synes det er beklagelig at rådene har blitt politiske gjennom at de har tatt inn klimasaken, fremfor at de er en mest mulig sann fremstilling av hva ulike typer mat gjør med kroppen. Aunmo legger frem forskningsevidens som peker i motsatt retning av kostholdsrådene norske myndigheter har lagt frem nylig. Han har mange suksesshistorier fra pasienter med autoimmune sykdommer, diabetes og andre sykdommer, som har blitt friske etter at de sluttet å spise bestemte typer planter, produkter fra planter eller utelukket dem helt fra kosten.Sjur Even Aunmo: • youtube.com • facebook.comGrønnsaker uten noen kjent form for gluten: • hodekål, blomkål, brokkoli, paprika, rødbeter, bladbete, squash, potet, søtpotet, gulrøtter, gresskar, romano-salat, indisk bladsennep, spinat, grønnkål • Obs: Selv om disse plantene ikke inneholder gluten, finnes det andre stoffer i dem som er uheldige. Paprika, for eksempel, hører til søtvier-familien, sammen med potet og tobakk. De forsvarer seg mot mennesker, dyr og insekter med lektiner og solanin. Spinat inneholder mye oksalat som stjeler kalsium fra kroppen. Det finnes igjen i nyrestener og mistenkes for å stimulere brystkreft. Grønnsaker inneholder druesukker, som er et viktig næringsstoff for kreft. Grønnsaker som vokser over bakken inneholder ofte mindre sukker enn de som vokser under bakken. De minst usunne grønnsakene på listen synes å være hodekål, blomkål og brokkoli, på tross av at disse danner goitrin, et stoff som motvirker dannelsen av stoffskiftehormon.Diverse kilder: • Mindre kjøtt, mer plantebasert: Her kommer De nordiske ernæringsanbefalingene 2023 • Helsedirektoratets kostråd • The Seven Countries Study (søk) • Paleo diet (søk) • Keto diet (søk) • Carnivore diet (søk)› Relaterte AJP-episoder: • AJP 61 | Sjur Even Aunmo – Fikk sparken for å snakke om bivirkningerRelatert forskning:› FETT› https://doi.org/10.1136/bmj.e8707 Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis› https://doi.org/10.1136/bmj.i1246 Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73)› https://doi.org/10.3945/ajcn.2009.27725 Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease› https://doi.org/10.1186/s12937-017-0254-5 The effect of replacing saturated fat with mostly n-6 polyunsaturated fat on coronary heart disease: a meta-analysis of randomised controlled trials› https://doi.org/10.1016/j.jacc.2020.05.077 Saturated Fats and Health: A Reassessment and Proposal for Food-Based Recommendations: JACC State-of-the-Art Review› http://dx.doi.org/10.1136/openhrt-2014-000196 Evidence from randomised controlled trials did not support the introduction of dietary fat guidelines in 1977 and 1983: a systematic review and meta-analysis› http://dx.doi.org/10.1136/bmjebm-2019-111180 Fat or fiction: the diet-heart hypothesis› https://www.mn.uio.no/ibv/tjenester/kunnskap/plantefys/leksikon/h/herdet-fett.html› https://doi.org/10.1046/j.1471-4159.1997.68052092.x 4-Hydroxynonenal-Derived Advanced Lipid Peroxidation End Products Are Increased in Alzheimer's Disease› https://doi.org/10.1016/j.freeradbiomed.2006.07.021 Induction of mitochondrial nitrative damage and cardiac dysfunction by chronic provision of dietary ω-6 polyunsaturated fatty acids› https://doi.org/10.1038/s41467-018-05614-6 Dietary stearic acid regulates mitochondria in vivo in humans› http://dx.doi.org/10.17140/AFTNSOJ-1-123 Oxidation of Polyunsaturated Fatty Acids and its Impact on Food Quality and Human Health› https://doi.org/10.1194/jlr.M026179 Dietary oxidized n-3 PUFA induce oxidative stress and inflammation: role of intestinal absorption of 4-HHE and reactivity in intestinal cells› https://doi.org/10.1021/jf049207s Effect of the Type of Frying Culinary Fat on Volatile Compounds Isolated in Fried Pork Loin Chops by Using SPME-GC-MS› STATINER (KOLESTEROLSENKENDE STOFFER)› http://dx.doi.org/10.1136/bmjopen-2018-023085 Statins for the primary prevention of cardiovascular disease: an overview of systematic reviews› http://dx.doi.org/10.1136/bmjopen-2014-007118 The effect of statins on average survival in randomised trials, an analysis of end point postponement› https://doi.org/10.1001/archinternmed.2010.182 Statins and All-Cause Mortality in High-Risk Primary Prevention: A Meta-analysis of 11 Randomized Controlled Trials Involving 65 229 Participants› https://www.felleskatalogen.no/medisin/lipitor-upjohn-eesv-pfizer-560999› https://www.felleskatalogen.no/medisin/zocor-organon-565655› https://www.legemiddelhandboka.no/L8.15.1/Statiner› https://www.bmj.com/campaign/statins-open-data Statins - a call for transparent data› https://doi.org/10.1001/archinternmed.2011.625 Statin Use and Risk of Diabetes Mellitus in Postmenopausal Women in the Women's Health Initiative› https://doi.org/10.1007/s40264-017-0620-4 Amyotrophic Lateral Sclerosis Associated with Statin Use: A Disproportionality Analysis of the FDA's Adverse Event Reporting System› https://doi.org/10.1001/jamainternmed.2020.6084 Evaluation of Time to Benefit of Statins for the Primary Prevention of Cardiovascular Events in Adults Aged 50 to 75 Years› https://doi.org/10.1016/j.atherosclerosis.2022.07.003 Statin therapy for the primary prevention of cardiovascular disease: Cons› http://doi.org/10.1161/STROKEAHA.121.034576 Lipid-Lowering Therapy and Hemorrhagic Stroke RiskLipid-Lowering Therapy and Hemorrhagic Stroke Risk› KJØTT› https://www.acpjournals.org/doi/full/10.7326/M19-0622 Effect of Lower Versus Higher Red Meat Intake on Cardiometabolic and Cancer Outcomes A Systematic Review of Randomized Trials› https://doi.org/10.3945/ajcn.116.142521 Total red meat intake of ≥0.5 servings/d does not negatively influence cardiovascular disease risk factors: a systemically searched meta-analysis of randomized controlled trials› https://doi.org/10.3945/ajcn.113.062638 Meat intake and cause-specific mortality: a pooled analysis of Asian prospective cohort studies› FISK› https://doi.org/10.1093/jn/nxab112 Biomarkers and Fatty Fish Intake: A Randomized Controlled Trial in Norwegian Preschool Children› https://doi.org/10.1007/s12016-013-8363-1 Fish Allergy: In Review› KOLESTEROL› http://dx.doi.org/10.1136/bmjopen-2015-010401 Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review› https://doi.org/10.1016/j.mehy.2018.09.019 Inborn coagulation factors are more important cardiovascular risk factors than high LDL-cholesterol in familial hypercholesterolemia› PMID: 18277343 ApoB/ApoA1 ratio and subclinical atherosclerosis› https://doi.org/10.1016/0021-9150(89)90130-5 Cigarette smoking renders LDL susceptible to peroxidative modification and enhanced metabolism by macrophages› https://doi.org/10.1161/01.CIR.93.7.1346 Cigarette Smoking Potentiates Endothelial Dysfunction of Forearm Resistance Vessels in Patients With Hypercholesterolemia: Role of Oxidized LDL› https://doi.org/10.1161/01.CIR.97.20.2012 Passive Smoking Induces Atherogenic Changes in Low-Density Lipoprotein› https://doi.org/10.1016/j.atherosclerosis.2008.04.046 Smoking and smoking cessation—The relationship between cardiovascular disease and lipoprotein metabolism: A review› https://doi.org/10.1161/ATVBAHA.113.300156 Smoking and Cardiovascular Disease› https://doi.org/10.3402/fnr.v59.29240 LDL biochemical modifications: a link between atherosclerosis and aging› https://doi.org/10.1016/j.cjca.2017.07.015 Association Between Circulating Oxidized LDL and Atherosclerotic Cardiovascular Disease: A Meta-analysis of Observational Studies› https://doi.org/10.1054/plef.2000.0204 Why is glycated LDL more sensitive to oxidation than native LDL? A comparative study.› KARBOHYDRAT› https://www.helsedirektoratet.no/rapporter/anbefalinger-om-kosthold-ernaering-og-fysisk-aktivitet/Anbefalinger%20om%20kosthold%20ern%C3%A6ring%20og%20fysisk%20aktivitet.pdf/_/attachment/inline/2f5d80b2-e0f7-4071-a2e5-3b080f99d37d:2aed64b5b986acd14764b3aa7fba3f3c48547d2d/Anbefalinger%20om%20kosthold%20ern%C3%A6ring%20og%20fysisk%20aktivitet.pdf› FRUKTOSE› https://doi.org/10.1016/j.jhep.2021.02.027 Fructose- and sucrose- but not glucose-sweetened beverages promote hepatic de novo lipogenesis: A randomized controlled trial› https://doi.org/10.1093/ajcn/nqaa332 Effects of fructose restriction on liver steatosis (FRUITLESS); a double-blind randomized controlled trial› https://doi.org/10.5223/pghn.2021.24.5.483 The Relationship between Daily Fructose Consumption and Oxidized Low-Density Lipoprotein and Low-Density Lipoprotein Particle Size in Children with Obesity› KUNSTIG SØTNING› https://doi.org/10.1016/s0378-8741(99)00081-1 Effects of chronic administration of Stevia rebaudiana on fertility in rats› https://doi.org/10.1371/journal.pone.0000698 Intense Sweetness Surpasses Cocaine Reward› https://doi.org/10.1016/j.cell.2022.07.016 Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance› https://doi.org/10.1289/ehp.8711 First Experimental Demonstration of the Multipotential Carcinogenic Effects of Aspartame Administered in the Feed to Sprague-Dawley Rats› https://doi.org/10.1289/ehp.10271 Life-Span Exposure to Low Doses of Aspartame Beginning during Prenatal Life Increases Cancer Effects in Rats› DIABETES› https://doi.org/10.1001/jama.295.6.655 Low-Fat Dietary Pattern and Risk of Cardiovascular DiseaseThe Women's Health Initiative Randomized Controlled Dietary Modification Trial – se side 661, økt hjerte/kar-risk sfa. Lavfett-diett› https://doi.org/10.3945/ajcn.110.010843 Effects of a low-fat dietary intervention on glucose, insulin, and insulin resistance in the Women's Health Initiative (WHI) Dietary Modification trial› https://doi.org/10.1007/s11745-008-3274-2 AOCS Lipids (lavranket journal) Carbohydrate Restriction has a More Favorable Impact on the Metabolic Syndrome than a Low Fat Diet› https://doi.org/10.1161/ATVBAHA.114.303284 Small Dense Low-Density Lipoprotein-Cholesterol Concentrations Predict Risk for Coronary Heart Disease- ArtThromVas prospektiv kohort› https://doi.org/10.1097/MOL.0b013e328306a057 Glycation as an atherogenic modification of LDL : Current Opinion in Lipidology› https://doi.org/10.1016/0021-9150(93)90084-8 Glycosylated low density lipoprotein is more sensitive to oxidation: implications for the diabetic patient?› https://doi.org/10.2337/diabetes.55.02.06.db05-1103 Loss of Endothelial Glycocalyx During Acute Hyperglycemia Coincides With Endothelial Dysfunction and Coagulation Activation In Vivo› https://doi.org/10.1016/S0895-7061(00)01260-7 Blood viscosity and blood pressure: role of temperature and hyperglycemia› https://doi.org/10.2337/dc13-1374 Blood Viscosity in Subjects With Normoglycemia and Prediabetes› https://doi.org/10.1007/s00592-017-1004-z Elevated 1-h post-challenge plasma glucose levels in subjects with normal glucose tolerance or impaired glucose tolerance are associated with whole blood viscosity› https://doi.org/10.1080/09674845.2010.11730293 Blood viscosity at different stages of diabetes pathogenesis.› DIABETES-DEMENS› https://doi.org/10.1212/WNL.53.9.1937 Diabetes mellitus and the risk of dementia - The Rotterdam Study› https://doi.org/10.1016/S1474-4422(05)70284-2 Lancet Neurology 2006, sysrew lavere evidensgrad. Risk of dementia in diabetes mellitus: a systematic review› https://doi.org/10.1111/j.1445-5994.2012.02758.x Diabetes as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies› https://doi.org/10.1016/j.arr.2019.100944 Diabetes mellitus and risks of cognitive impairment and dementia: A systematic review and meta-analysis of 144 prospective studies› https://doi.org/10.1177/193229680800200619 Alzheimer's Disease is Type 3 Diabetes—Evidence Reviewed› https://doi.org/10.3390/ijerph120708281 Evaluating the Association between Diabetes, Cognitive Decline and Dementia› https://doi.org/10.3390/ijms21030934 Ketone Bodies Promote Amyloid-β1–40 Clearance in a Human in Vitro Blood–Brain Barrier Model› https://doi.org/10.1038/s41574-018-0048-7 Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications› https://doi.org/10.1038/s41586-020-2247-3 APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline› DIABETES NYRESYKDOM› https://doi.org/10.2337/diacare.27.2007.S79 Nephropathy-in-Diabetes Nephropathy in Diabetes› Diabetic Nephropathy: Diagnosis, Prevention, and Treatment› https://doi.org/10.1016/S0272-6386(96)90538-7 Diabetic nephropathy in type II diabetes› DIABETES ØYESYKDOM› https://doi.org/10.1016/S0140-6736(09)62124-3 Diabetic retinopathy› https://doi.org/10.1016/S2213-8587(18)30128-1 Incidence and progression of diabetic retinopathy: a systematic review› DIABETES HJERTE- OG KAR-SYKDOM› https://doi.org/10.1001/jamacardio.2020.7073 Association of Lipid, Inflammatory, and Metabolic Biomarkers With Age at Onset for Incident Coronary Heart Disease in Women› PLANTE-ANTINÆRINGSSTOFF, VERN OG GIFT› https://doi.org/10.1016/j.foodchem.2008.01.056 Food Chemistry 2008 Bioaccessibility of Ca, Mg, Mn and Cu from whole grain tea-biscuits: Impact of proteins, phytic acid and polyphenols› https://doi.org/10.1002/mnfr.200900099 Phytate in foods and significance for humans: food sources, intake, processing, bioavailability, protective role and analysis.› https://doi.org/10.1046/j.1440-6047.1999.00038.x Oxalate content of foods and its effect on humans› https://doi.org/10.1104/pp.109.2.347 Lectins as plant defense proteins.› https://doi.org/10.1016/j.taap.2009.03.012 Effects of wheat germ agglutinin on human gastrointestinal epithelium: Insights from an experimental model of immune/epithelial cell interaction› https://doi.org/10.1038/s41531-018-0066-0 Ingestion of subthreshold doses of environmental toxins induces ascending Parkinsonism in the rat› https://doi.org/10.1016/S0140-6736(05)79894-9 Identification of intact peanut lectin in peripheral venous blood› https://doi.org/10.1136/bmj.318.7190.1023 Do dietary lectins cause disease?› https://doi.org/10.1016/S0015-0282(16)54596-8 Lectin binding of endometrium in women with unexplained infertility› https://doi.org/10.1016/S0271-5317(88)80133-7 Changes in organs and tissues induced by feeding of purified kidney bean (Phaseolus vulgaris) lectins› https://doi.org/10.3390/molecules20022014 Insecticidal Activity of Plant Lectins and Potential Application in Crop Protection› https://doi.org/10.1210/endo-113-6-1921 Bound Lectins that Mimic Insulin Produce Persistent Insulin-Like Activities› https://doi.org/10.1042/BJ20071137 Contribution of leptin receptor N-linked glycans to leptin binding› https://doi.org/10.1111/j.1365-2249.2007.03368.x Potato lectin activates basophils and mast cells of atopic subjects by its interaction with core chitobiose of cell-bound non-specific immunoglobulin E› https://doi.org/10.1002/(SICI)1521-4141(199903)29:03 Dietary lectins can induce in vitro release of IL-4 and IL-13 from human basophils› https://doi.org/10.1016/j.ekir.2018.07.020 Secondary Oxalate Nephropathy: A Systematic Review› http://dx.doi.org/10.1136/gut.16.3.193 The effect of tea on iron absorption.› PMID: 1862 Disler PB, Lynch SR, Torrance JD, et al. The mechanism of the inhibition of iron absorption by tea. The South African Journal of Medical Sciences. 1975 ;40(4):109-116.› https://doi.org/10.1016/0887-2333(95)00113-1 Effects of saponins and glycoalkaloids on the permeability and viability of mammalian intestinal cells and on the integrity of tissue preparationsin vitro› https://doi.org/10.1079/BJN2002725 The biological action of saponins in animal systems: a review› http://doi.org/10.1093/carcin/bgp082 Lung tumor promotion by curcumin› https://doi.org/10.3945/ajcn.2009.26736M Cancer incidence in vegetarians: results from the European Prospective Investigation into Cancer and Nutrition (EPIC-Oxford)› https://doi.org/10.3382/ps.0550716 Antithyroid Activity of Goitrin in Chicks› https://doi.org/10.1016/s0278-6915(82)80294-9 Hepatic effects of R-goitrin in in Sprague-Dawley rats› https://doi.org/10.1002/ana.24448 Vagotomy and subsequent risk of Parkinson's disease --> https://doi.org/10.1038/s41531-018-0066-0› Ingestion of subthreshold doses of environmental toxins induces ascending Parkinsonism in the rat› http://doi.org/10.1056/NEJMra2010852 Salicylate Toxicity› https://doi.org/10.1021/jf0113070 Relationship between Cyanogenic Compounds in Kernels, Leaves, and Roots of Sweet and Bitter Kernelled Almonds› https://doi.org/10.1179/146532810X12637745451951Cyanide poisoning caused by ingestion of apricot seeds› https://doi.org/10.3390/toxins11060324 Ricin: An Ancient Story for a Timeless Plant Toxin› https://doi.org/10.1016/j.taap.2009.03.012Effects of wheat germ agglutinin on human gastrointestinal epithelium: Insights from an experimental model of immune/epithelial cell interaction› GLUTEN› https://doi.org/10.1080/00365520500235334 Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines› https://doi.org/10.1053/j.gastro.2008.03.023 Gliadin Induces an Increase in Intestinal Permeability and Zonulin Release by Binding to the Chemokine Receptor CXCR3› https://doi.org/10.1016/j.jprot.2017.03.026 A curated gluten protein sequence database to support development of proteomics methods for determination of gluten in gluten-free foods› https://doi.org/10.1111/jgh.13703 What is gluten?› https://doi.org/10.1186/s41043-015-0032-y The opioid effects of gluten exorphins: asymptomatic celiac disease› https://doi.org/10.1016/j.peptides.2015.07.013 Bioactive peptides derived from natural proteins with respect to diversity of their receptors and physiological effects› SOYA› https://doi.org/10.1271/bbb.70516Soymorphins, novel μ opioid peptides derived from soy β-conglycinin β-subunit, have anxiolytic activities.› TILSETNINGSSTOFFER› https://doi.org/10.3233/NHA-170023 A randomized trial of the effects of the no-carrageenan diet on ulcerative colitis disease activity› https://doi.org/10.1053/j.gastro.2021.11.006 Randomized Controlled-Feeding Study of Dietary Emulsifier Carboxymethylcellulose Reveals Detrimental Impacts on the Gut Microbiota and Metabolome› https://doi.org/10.1002/ijc.21925 Processed meat consumption, dietary nitrosamines and stomach cancer risk in a cohort of Swedish women› KETOGENISITET/KREFT› https://oslo-universitetssykehus.no/behandlinger/pet-undersokelse› https://stanfordhealthcare.org/medical-tests/p/pet-scan/what-to-expect.html› https://www.sciencedirect.com/topics/medicine-and-dentistry/warburg-effect› https://doi.org/10.1016/j.tibs.2015.12.001 The Warburg Effect: How Does it Benefit Cancer Cells?› https://doi.org/10.1080/01635581.2019.1650942 Feasibility, Safety, and Beneficial Effects of MCT-Based Ketogenic Diet for Breast Cancer Treatment: A Randomized Controlled Trial Study› https://doi.org/10.1093/jnci/djs399 Dietary Glycemic Load and Cancer Recurrence and Survival in Patients with Stage III Colon Cancer: Findings From CALGB 89803› https://doi.org/10.18632/aging.101382 Ketogenic diet in cancer therapy› IATROGENISITET› https://doi.org/10.1111/eci.12834 How to survive the medical misinformation mess› https://doi.org/10.1111/jlme.12068 Institutional Corruption of Pharmaceuticals and the Myth of Safe and Effective Drugs› https://doi.org/10.1136/bmj.f3830 Why we can't trust clinical guidelines› https://doi.org/10.1016/S0140-6736(15)60696-1 Offline: What is medicine's 5 sigma?› https://apjcn.nhri.org.tw/server/apjcn/procnutsoc/1990-1999/1995/1995%20p1-10.pdfLast ned episodenInnspilt: 2023-07-18Publisert: 2023-07-28Støtte Antijantepodden?Liker du arbeidet vi gjør, og vil bidra til at vi lager flere episoder?Finn ut hvordan du kan gi noe tilbake ved å gå til antijantepodden.com!Meld deg på vårt nyhetsbrev

Evidence shows that all over the world, people are snacking more — with the United Kingdom and the United States leading the way in unhealthy snacking habits. But what exactly counts as a snack? And is all snacking unhealthy?Snacking can be a confusing and controversial topic. There are various opinions and myths about what's good for you. Many people struggle to make healthy choices, while others may be unaware of the impact of snacking habits on their gut health and overall well-being.In today's episode, Jonathan is joined by ZOE regulars and renowned experts Sarah Berry and Tim Spector for an enlightening discussion that will help you snack smarter. Armed with the latest scientific research, they unravel the complexities of snacking and share evidence-based insights on what's truly beneficial for your body. Along the way, they cover healthy options, snack timing, and what we should all be avoiding.If you want to uncover the right foods for your body, head to joinzoe.com/podcast and get 10% off your personalized nutrition program.Timecodes:00:00 Introduction01:23 Quick Fire Questions04:03 What is a snack?04:55 How much energy comes from snacks?05:40 Cultural differences with snacks08:33 What happens when we snack?10:29 Are some healthy looking bars actually bad for us?12:16 Do ulta-processed snacks make us hungrier?13:57 What effect do additives and emulsifiers have?15:04 Results of study on healthy vs unhealthy snacks15:22 What impact does snacking have on our gut?18:00 Why could snacking be unhealthy?18:56 What are the concerns around snacking frequency?19:50 Does the quality of your snack make a difference?21:31 Could skipping breakfast be healthy for us?23:17 Does timing of snacking have any influence on our health?28:42 How could time-restricted eating benefit us?32:20 What is the impact of snacking on weight gain?34:15 What impact does snacking have on blood sugar?36:25 How people on different routines react to snacking38:27 What does the recent ZOE research show us on the topics of snacking?40:16 How bad is late night snacking for our health?42:19 How should we be snacking?46:30 How has snacking changed over time?47:26 Actionable advice on snacking52:52 How much do your meals impact snacking?56:50 Summary59:40 Goodbyes59:44 OutroIn today's episode:Meal patterns across ten European countries – results from the European Prospective Investigation into Cancer and Nutrition (EPIC) calibration study https://www.cambridge.org/core/journals/public-health-nutrition/article/meal-patterns-across-ten-european-countries-results-from-the-european-prospective-investigation-into-cancer-and-nutrition-epic-calibration-study/A662BDB7A9AD3631BD6AD98946FE765F# What is a snack, why do we snack, and how can we choose better snacks? A review of the definitions of snacking, motivations to snack, contributions to dietary intake, and recommendations for improvement https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863261/Snacking on whole almonds for 6 weeks improves endothelial function and lowers LDL cholesterol but does not affect liver fat and other cardiometabolic risk factors in healthy adults: The ATTIS study, a randomized...

Videos: The Old World Order Is About To Collapse – Peter Zeihan | Modern Wisdom Podcast 514 (0:20 to 20:00) Tulsi Gabbard Speech LIVE | Tulsi Gabbard Accuses Joe Biden | US News Latest | English News LIVE Noam Chomsky – The Crimes of U.S. Presidents Clare Daly Latest Top 7 Contributions in the EU. (First 1 of 7 ) (start @ 0:17)   Carotenoids linked to lower diabetes Utrecht University Medical Center (Netherlands), October 21, 2022 A prospective study of 37,846 subjects links higher carotenoid consumption to a lower risk of diabetes. People who consume a diet high in antioxidant-rich carotenoids have a lower occurrence of diabetes, according to a new study. The researchers linked higher intakes of beta and alpha carotene with lower risks of type 2 diabetes. The research analyzed data from validated food frequency questionnaires from 37,846 participants in the European Prospective Investigation into Cancer and Nutrition, which followed subjects for a mean of 10 years. They focused on dietary carotenoid intake levels consisting of beta-carotene, alpha-carotene, beta-cryptoxanthin, lycopene, lutein, zeaxanthin and the total of these six carotenoids. The study also examined how smoking (tobacco, not carotenoids) played into the subjects' risk of developing diabetes. Thirty-one percent of the subjects smoked. “This study shows that diets high in beta-carotene and alpha-carotene are associated with reduced type 2 diabetes in generally healthy men and women,” concluded the authors of the study, which appeared in the journal Nutrition, Metabolism & Cardiovascular Disease. Smoking, according the researchers' analysis, made no difference in the risk of diabetes. An earlier study linked low carotenoids with increased risk of colon cancer. Animal and human studies have found that beta-carotene can enhance many aspects of immunity. Some of this research has shown that beta-carotene boosts the activity of “natural-killer” cells, a type of immune cell that fights cancer. Melatonin and CoQ10 for migraines University of California, Los Angeles, October 20, 2022 Migraines affect about 12 percent of people in the United States, occurring more often in women, in people between the ages of 30 and 39, and within families. A retrospective analysis of migraine sufferers found that emotional stress was a trigger for 80 percent of them, missing a meal was a trigger for 57 percent, and lack of sleep was a trigger for 50 percent. In a study, patients who experienced migraine headaches two to eight times per month were randomly assigned to take either a placebo or 100 milligrams of CoQ10 three times per day for at least three months. The authors measured success as a greater than 50 percent reduction in the frequency of migraines. Only 14.4 percent of those who took the placebo showed this level of reduction, but 47.6 percent of those who took CoQ10 reduced their frequency of migraines by that amount. Then there's the B vitamin riboflavin. Another study found that 59 percent of people who took a daily dose of 400 milligrams had a greater than 50 percent reduction in the frequency of migraines, compared to 15 percent of those who took a placebo. However, it took three months for riboflavin to show this benefit. Knowing that sleep problems increase the risk of migraines, researchers compared the effects of 3 milligrams of melatonin to the effects of the anti-depressant amitriptyline or of a placebo. After three months, 54.4 percent of people who took melatonin had a 50 percent or greater reduction in frequency of headaches compared to 39.1 percent in the amitriptyline group and 20 percent in the placebo group. Study: Eating foods high in healthy fats helps fight off skin cancer University Medical Center Groningen (Netherlands), October 21, 2022 A study has found that foods rich in healthy fats can help protect against skin cancer and boost the effectiveness of immunotherapy among skin cancer patients. Results showed that patients who followed the Mediterranean diet and received the drugs were more likely to survive and remain progression-free after 12 months. The Mediterranean diet includes lots of superfoods like olive oil, nuts and fish, along with fruits, vegetables and whole grains. The diet is popular because it is associated with amazing health benefits such as a longer lifespan and protection against cardiovascular diseases. For the study, researchers from the U.K. and UMCG tracked the diets of 91 patients with advanced melanoma. The volunteers were all taking Immune Checkpoint Inhibitors (ICIs). ICIs have worked well for those with melanoma, the most serious type of skin cancer. Researchers analyzed the patients' progress and gave them frequent X-ray check ups. The findings revealed that the patients following a Mediterranean diet responded better to ICIs and were also most likely to not get any worse a year later. According to the results of the study, whole grains and legumes in particular also helped reduce the likelihood of patients experiencing side effects from the immunotherapy drugs kike colitis or inflammation of the colon. Meanwhile, those who consumed a lot of red and processed meat experienced more side effects. Exercise Matters Regardless of Genetics When it Comes to Longevity University of California San Diego, October 21, 2022 A study from the University of California San Diego found that engaging in physical activity contributed to your longevity, regardless of genetic predispositions. This study of over 5,400 postmenopausal women aged 63 and up examined the role fitness habits play in longevity. The findings? Even light activity makes a difference, correlating with a 45% reduced risk of death, compared with those leading a sedentary lifestyle. Meanwhile, moderate-to-vigorous activity was found to have an even greater impact, with a 54% reduced risk of death. These results were consistent among the women, regardless of any specific genetic predisposition. “Even if you aren't likely to live long based on your genes, you can still extend your lifespan by engaging in positive lifestyle behaviors such as regular exercise and sitting less,” concluded senior author and assistant professor at UC San Diego, Aladdin H. Shadyab, Ph.D. The UC San Diego study sought to answer the question of whether this risk changes if the person is genetically predisposed to live a long life. The conclusion is that no, it does not. Exercise increased the likelihood to live longer regardless of the subject's genetic profile, just as being sedentary increased their risk to die younger than would have otherwise been predicted based on their genes. When accounting for activity of the subjects and adjusting for variables like race, age, BMI, smoker vs. nonsmoker and overall health status the authors found: The highest quartile for light physical activity had a whopping 45% reduced risk of death compared to those in the lowest quartile The highest quartile of moderate-to vigorous activity category had a 54% reduced risk of death vs. the lowest The highest quartile for sedentary time doubled their risk of death compared to those with the lowest sedentary quartile This association of activity and longevity carried through even with the genetic risk score taken into account, confirming that the benefit of exercise on longevity was present, regardless of genetics. Shadyab emphasized the importance of these findings and physical activity's impact on living longer, stating, “Even if your genes predispose you to a long life, remaining physically active is still important to achieve longevity.” Pesticide Free Organic Food Lowers Blood Cancer Risk by 86% Centre of Research in Epidemiology and Statistics (France), October 22, 2022 Cutting out pesticides by eating only organic food could slash your cancer risk by up to 86 percent, a new study claims. The biggest impact was seen on non-Hodgkin's lymphoma risk, which plummeted among those who shunned chemical-sprayed food, according to the survey of nearly 70,000 French adults. Overall, organic eaters were 25 percent less likely to develop any cancer, and their risks of skin and breast cancers dropped by a third. The health benefit was far greater for obese people, they found. However, the diet had no significant effect on bowel cancer – which is soaring in numbers globally – or prostate cancer. ‘Our results indicate that higher organic food consumption is associated with a reduction in the risk of overall cancer,' lead author Dr Julia Baudry of the Centre of Research in Epidemiology and Statistics Sorbonne, Paris said. ‘We observed reduced risks for specific cancer sites – postmenopausal breast cancer, non-Hodgkin's lymphoma, and all lymphomas – among individuals with a higher frequency of organic food consumption. Dr Baudry explained among the environmental risk factors for cancer there was growing evidence of a link between exposure to pesticides notably in farm workers and cancer development. ‘Because of their lower exposure to pesticide residues, it can be hypothesised that high organic food consumers may have a lower risk of developing cancer. The cohort, who were 78 percent female and an average age of 44 were broken up into four groups according their organic diet food scores. Factoring in known cancer risks, the proportion of participants in the top quartile for eating organic food who got certain cancers was a fraction compared to those in the bottom quartile. The most common was 459 breast cancers, followed by 180 prostate cancers, 135 skin cancers, 99 colorectal cancers, 47 non-Hodgkin lymphomas, and 15 other lymphomas. High organic food scores were inversely associated with the overall risk of cancer being 25 percent less for those of the top quartile compared to the bottom. WHO highlights high cost of physical inactivity in first-ever global report World Health Organization, October 21, 2022 Almost 500 million people will develop heart disease, obesity, diabetes or other noncommunicable diseases (NCDs) attributable to physical inactivity, between 2020 and 2030, costing US$ 27 billion annually, if governments don't take urgent action to encourage more physical activity among their populations. The Global status report on physical activity 2022, published by the World Health Organization, measures the extent to which governments are implementing recommendations to increase physical activity across all ages and abilities. Data from 194 countries show that overall, progress is slow and that countries need to accelerate the development and implementation of policies to increase levels of physical activity and thereby prevent disease and reduce burden on already overwhelmed health care systems. Less than 50% of countries have a national physical activity policy, of which less than 40% are operational Only 30% of countries have national physical activity guidelines for all age groups While nearly all countries report a system for monitoring physical activity in adults, 75% of countries monitor physical activity among adolescents, and less than 30% monitor physical activity in children under 5 years In policy areas that could encourage active and sustainable transport, only just over 40% of countries have road design standards that make walking and cycling safer. The economic burden of physical inactivity is significant and the cost of treating new cases of preventable non-communicable diseases (NCDs) will reach nearly US$ 300 billion by 2030, around US$ 27 billion annually. The report calls for countries to prioritize physical activity as key to improving health and tackling NCDs, integrate physical activity into all relevant policies, and develop tools, guidance and training to improve implementation.

Halo Listener Apakah listener sering mager alias malas gerak? kebiasaan mager biasanya emang telanjur merasa nyaman sih dan memang kebiasaan malas gerak cenderung sulit diubah. Namun, apa pun alasannya, perlu diketahui bahwa malas gerak harus segera disudahi karena diam-diam dapat membahayakan kesehatan tubuh kamu lo listener. Kebiasan malas gerak ternyata menjadi 1 dari 10 penyebab kematian terbanyak di dunia lo listener. Dipertegas oleh data dari European Prospective Investigation into Cancer and Nutrition (EPIC) tahun 2008, kematian karena kemageran mencapai 2 kali lipat jumlahnya daripada kasus kematian akibat obesita Di Episode kali ini Amir dan Indana akan membahas kebiasaan mager yang banyak terjadi dikalangan anak muda Jadi Yuk segera dengarkan sekarang dan jangan lupa dengarkan terus Banana setiap hari Jumat di Channel Podcast Bingkai Suara atau kunjungi website kita di www.bingkaikarya.com Supported by EJSC Malang Business : bingkaikaryaid@gmail.com

Allmennlege Sjur Even Aunmo fikk sparken som fastlegevikar fordi han fortalte pasienter at COVID-19-vaksinen kan gi bivirkninger. Dette er noe han plikter å gjøre ifølge Pasient- og brukerrettighetsloven § 4. Aunmo har satt seg grundig inn i forskningen på disse vaksinene, og påpeker at de for det første er eksperimentelle på dette stadiet. Videre er det Pfizer selv som har finansiert sin studie, en ansatt fikk sparken fordi hun varslet om at blindingen (anonymiseringen) var brutt, personer har blitt tatt ut av studien uten at det er oppgitt noen god grunn og rådataene for studien er ikke offentliggjort. Selv har han sett flere bivirkninger, som kraftige menstruasjonsblødninger, hjerteproblemer og alvorlige nevrologiske bivirkninger. Han frykter at underrapportering kan medføre at bivirkningstallene fra Statens legemiddelverk er for lave. KILDER:› COVID-19 • https://clinicaltrials.gov/ct2/show/NCT04368728 • https://clinicaltrials.gov/ct2/show/NCT04470427 • Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine • Efficacy of the mRNA-1273 SARS-CoV-2 Vaccine at Completion of Blinded Phase • https://covid-nma.com/vaccines/variants/ • https://covid-nma.com/vaccines/index.php?search_by=1&search_input=1273&submit=Validate#moteur_recherche • How significant is the Ventavia scandal? • Covid-19: Researcher blows the whistle on data integrity issues in Pfizer's vaccine trial • CDC-vurdering av Modernas studie • https://www.bmj.com/company/newsroom/editors-call-for-covid-19-vaccine-and-treatment-data-to-be-available-for-public-scrutiny/ • https://www.nrk.no/norge/norges-forste-koronavaksine-settes-1.15304159, lest 20.3.22 • https://tidsskriftet.no/2021/05/originalartikkel/dodsfall-i-sykehjem-etter-covid-19-vaksine ◦ https://www.fhi.no/hn/helseregistre-og-registre/dodsarsaksregisteret/tall-for-covid-19-assosierte-dodsfall-i-dodsarsaksregisteret-i-2020/ ◦ https://legemiddelverket.no/Documents/Bivirkninger%20og%20sikkerhet/Rapporter%20og%20oversikter/Koronavaksiner/20211028%20Rapport%20over%20meldte%20bivirkninger%20av%20koronavaksine.pdf ◦ Surveillance for safety after immunization; vaccine adverse event reporting system (VAERS) - United States 1991-2001 ◦ Mandatory Reporting of Infectious Diseases by Clinicians ◦ Myopericarditis after vaccination, Vaccine Adverse Event Reporting System (VAERS), 1990–2018 ◦ https://www.nrk.no/livsstil/_-en-medisinsk-katastrofe-1.10880384 ◦ https://legemiddelverket.no/nyheter/bivirkninger-av-vaksiner-hva-lerte-vi-av-pandemien-i-2009#ble-det-meldt-noen-d%C3%B8dsfall? ◦ The illusion of evidence based medicine ‧ Amerikanske Centers for Disease Control om underrapportering ‧ Studie fra det medisinske tidsskriftet JAMA om underrapportering ‧ Studie fra det medisinske tidsskriftet Vaccine om underrapportering ‧ Fra det amerikanske registrerings-systemet VAERS om deres system ‧ Randomised Clinical Trials of COVID-19 Vaccines: Do Adenovirus-Vector Vaccines Have Beneficial Non-Specific Effects? ‧ Lancet 2022. Samlestudie RCT. Obs: Preprrint, ikke fagfallevurdert enda. Signifikant og stor forskjell mellom Pfizer/Moderna og svekket-virus-vaksiner.› FETT • Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis • Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73) • Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease • The effect of replacing saturated fat with mostly n-6 polyunsaturated fat on coronary heart disease: a meta-analysis of randomised controlled trials • Saturated Fats and Health: A Reassessment and Proposal for Food-Based Recommendations: JACC State-of-the-Art Review • http://dx.doi.org/10.1136/openhrt-2014-000196 • Fat or fiction: the diet-heart hypothesis | BMJ Evidence-Based Medicine • https://www.mn.uio.no/ibv/tjenester/kunnskap/plantefys/leksikon/h/herdet-fett.html • 4-Hydroxynonenal-Derived Advanced Lipid Peroxidation End Products Are Increased in Alzheimer's Disease • https://doi.org/10.1016/j.freeradbiomed.2006.07.021 ◦ Dietary stearic acid regulates mitochondria in vivo in humans - Nature Communications ◦ 33.9 10.17140/AFTNSOJ-1-123 Oxidation of Polyunsaturated Fatty Acids and its Impact on Food Quality and Human Health ◦ Dietary oxidized n-3 PUFA induce oxidative stress and inflammation: role of intestinal absorption of 4-HHE and reactivity in intestinal cells ◦ Effect of the Type of Frying Culinary Fat on Volatile Compounds Isolated in Fried Pork Loin Chops by Using SPME-GC-MS› STATINER • BMJ RCT sysrew/meta Statins for the primary prevention of cardiovascular disease: an overview of systematic reviews • The effect of statins on average survival in randomised trials, an analysis of end point postponement • JAMA RCT-meta 2010 - Statins and All-Cause Mortality in High-Risk Primary Prevention: A Meta-analysis of 11 Randomized Controlled Trials Involving 65 229 Participants • https://www.felleskatalogen.no/medisin/lipitor-upjohn-eesv-pfizer-560999 • https://www.felleskatalogen.no/medisin/zocor-organon-565655 • https://www.legemiddelhandboka.no/L8.15.1/Statiner • Statins - a call for transparent data - The BMJ • Statin Use and Risk of Diabetes Mellitus in Postmenopausal Women in the Women's Health Initiative› KJØTT • Effect of Lower Versus Higher Red Meat Intake on Cardiometabolic and Cancer Outcomes A Systematic Review of Randomized Trials • Total red meat intake of ≥0.5 servings/d does not negatively influence cardiovascular disease risk factors: a systemically searched meta-analysis of randomized controlled trials› KOLESTEROL • Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review • Inborn coagulation factors are more important cardiovascular risk factors than high LDL-cholesterol in familial hypercholesterolemia • PMID: 18277343 ApoB/ApoA1 ratio and subclinical atherosclerosis ◦ Cigarette smoking renders LDL susceptible to peroxidative modification and enhanced metabolism by macrophages ◦ Cigarette Smoking Potentiates Endothelial Dysfunction of Forearm Resistance Vessels in Patients With Hypercholesterolemia: Role of Oxidized LDL ◦ Passive Smoking Induces Atherogenic Changes in Low-Density Lipoprotein ◦ Smoking and smoking cessation—The relationship between cardiovascular disease and lipoprotein metabolism: A review ◦ Smoking and Cardiovascular Disease ◦ LDL biochemical modifications: a link between atherosclerosis and aging ◦ Association Between Circulating Oxidized LDL and Atherosclerotic Cardiovascular Disease: A Meta-analysis of Observational Studies› KARBOHYDRAT • https://www.helsedirektoratet.no/rapporter/anbefalinger-om-kosthold-ernaering-og-fysisk-aktivitet/Anbefalinger%20om%20kosthold%20ern%C3%A6ring%20og%20fysisk%20aktivitet.pdf/_/attachment/inline/2f5d80b2-e0f7-4071-a2e5-3b080f99d37d:2aed64b5b986acd14764b3aa7fba3f3c48547d2d/Anbefalinger%20om%20kosthold%20ern%C3%A6ring%20og%20fysisk%20aktivitet.pdf› DIABETES • JAMA WMI 2006Low-Fat Dietary Pattern and Risk of Cardiovascular DiseaseThe Women's Health Initiative Randomized Controlled Dietary Modification Trial – se side 661, økt hjerte/kar-risk sfa. Lavfett-diett • AmJourClinNutr WMI 2011 Effects of a low-fat dietary intervention on glucose, insulin, and insulin resistance in the Women's Health Initiative (WHI) Dietary Modification trial • AOCS Lipids (lavranket journal) Carbohydrate Restriction has a More Favorable Impact on the Metabolic Syndrome than a Low Fat Diet • Small Dense Low-Density Lipoprotein-Cholesterol Concentrations Predict Risk for Coronary Heart Disease- ArtThromVas prospektiv kohort • Glycation as an atherogenic modification of LDL : Current Opinion in Lipidology • Glycosylated low density lipoprotein is more sensitive to oxidation: implications for the diabetic patient? • Loss of Endothelial Glycocalyx During Acute Hyperglycemia Coincides With Endothelial Dysfunction and Coagulation Activation In Vivo› DIABETES-DEMENS • AgeingResearchRewiew 2019 sysrew/meta 144 prospektive studier – 58 % økt risiko demens • Int. Med. Journ. 2012 meta-analyse av prospektive kohorter dia-demens-risk 51 % økning demens • Lancet Neurology 2006, sysrew lavere evidensgrad. Risk of dementia in diabetes mellitus: a systematic review • Diabetes mellitus and the risk of dementia - The Rotterdam Study – prospektiv kohort • JDST 2008 Alzheimer's Disease is Type 3 Diabetes—Evidence Reviewed • MDPI 2015 Evaluating the Association between Diabetes, Cognitive Decline and Dementia • Ketone Bodies Promote Amyloid-β1–40 Clearance in a Human in Vitro Blood–Brain Barrier Model - 2020 • Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implication - 2018 • APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline - 2020› HJERTE- OG KAR-SYKDOM • 10.1001/jamacardio.2020.7073 Association of Lipid, Inflammatory, and Metabolic Biomarkers With Age at Onset for Incident Coronary Heart Disease in Women› PLANTE-ANTINÆRINGSSTOFF OG VERN • Food Chemistry 2008 Bioaccessibility of Ca, Mg, Mn and Cu from whole grain tea-biscuits: Impact of proteins, phytic acid and polyphenols • Phytate in foods and significance for humans: food sources, intake, processing, bioavailability, protective role and analysis. Mol Nutr Food Res. 2009 Sep;53 Suppl 2:S330-75. • Oxalate content of foods and its effect on humans • Lectins as plant defense proteins • Effects of wheat germ agglutinin on human gastrointestinal epithelium: Insights from an experimental model of immune/epithelial cell interaction • Ingestion of subthreshold doses of environmental toxins induces ascending Parkinsonism in the rat • Identification of intact peanut lectin in peripheral venous blood • Do dietary lectins cause disease? BMJ • Lectin binding of endometrium in women with unexplained infertility • Changes in organs and tissues induced by feeding of purified kidney bean (Phaseolus vulgaris) lectins • Insecticidal Activity of Plant Lectins and Potential Application in Crop Protection • Bound Lectins that Mimic Insulin Produce Persistent Insulin-Like Activities • Contribution of leptin receptor N-linked glycans to leptin binding • Potato lectin activates basophils and mast cells of atopic subjects by its interaction with core chitobiose of cell-bound non-specific immunoglobulin E • 3.0.CO;2-T Dietary lectins can induce in vitro release of IL-4 and IL-13 from human basophils • Secondary Oxalate Nephropathy: A Systematic Review • The effect of tea on iron absorption • PMID: 1862 Disler PB, Lynch SR, Torrance JD, et al. The mechanism of the inhibition of iron absorption by tea. The South African Journal of Medical Sciences. 1975 ;40(4):109-116. • Effects of saponins and glycoalkaloids on the permeability and viability of mammalian intestinal cells and on the integrity of tissue preparationsin vitro • The biological action of saponins in animal systems: a review • Small Amounts of Gluten in Subjects With Suspected Nonceliac Gluten Sensitivity: A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Trial ◦ Obs: Kapsler brukt i studien ble supplert av legemiddelfirmaet Giuliani, som lager glutenfritt brød.› LEKK TARM • Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines • Gliadin Induces an Increase in Intestinal Permeability and Zonulin Release by Binding to the Chemokine Receptor CXCR3 • AmJourClinNu 2009 Cancer incidence in vegetarians: results from the European Prospective Investigation into Cancer and Nutrition (EPIC-Oxford) • FODMAP diet modulates visceral nociception by lipopolysaccharide-mediated intestinal inflammation and barrier dysfunction • 73.3 10.12688/f1000research.20510.1 All disease begins in the (leaky) gut: role of zonulin-mediated gut permeability in the pathogenesis of some chronic inflammatory diseases› LAVKARB • Effects of Low-Carbohydrate vs Low-Fat Diets on Weight Loss and Cardiovascular Risk Factors • BritJourNutr 2013 RCT-meta Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials • AnnIntMed 2004 A Low-Carbohydrate, Ketogenic Diet versus a Low-Fat Diet To Treat Obesity and Hyperlipidemia: A Randomized, Controlled Trial • JAMAIntMed A Randomized Trial of a Low-Carbohydrate Diet vs Orlistat Plus a Low-Fat Diet for Weight Loss • NEJM RCT 2006 A Low-Carbohydrate as Compared with a Low-Fat Diet in Severe Obesity • Short-term effects of severe dietary carbohydrate-restriction advice in Type 2 diabetes—a randomized controlled trial • Effects of a low carbohydrate diet on energy expenditure during weight loss maintenance: randomized trial • Effects of a low-carbohydrate diet on weight loss and cardiovascular risk factor in overweight adolescents • Comparison of the Atkins, Zone, Ornish, and LEARN Diets for Change in Weight and Related Risk Factors Among Overweight Premenopausal WomenThe A TO Z Weight Loss Study: A Randomized Trial • Efficacy and Safety of a High Protein, Low Carbohydrate Diet for Weight Loss in Severely Obese Adolescents • Long-Term Effects of a Novel Continuous Remote Care Intervention Including Nutritional Ketosis for the Management of Type 2 Diabetes: A 2-Year Non-randomized Clinical Trial› FRUKTOSE • JourHepatology 2021 Fructose- and sucrose- but not glucose-sweetened beverages promote hepatic de novo lipogenesis: A randomized controlled trial • Effects of fructose restriction on liver steatosis (FRUITLESS); a double-blind randomized controlled trial› KETOGENISITET/KREFT • https://oslo-universitetssykehus.no/behandlinger/pet-undersokelse • https://stanfordhealthcare.org/medical-tests/p/pet-scan/what-to-expect.html • https://www.sciencedirect.com/topics/medicine-and-dentistry/warburg-effect • The Warburg Effect: How Does it Benefit Cancer Cells? • NutrCanc 2019 Feasibility, Safety, and Beneficial Effects of MCT-Based Ketogenic Diet for Breast Cancer Treatment: A Randomized Controlled Trial Study • Dietary Glycemic Load and Cancer Recurrence and Survival in Patients with Stage III Colon Cancer: Findings From CALGB 89803 • Ketogenic diet in cancer therapy› IATROGEN SKADE • https://tidsskriftet.no/2000/10/kronikk/uheldige-hendelser-i-helsetjenesten-forebygging-og-handteringDownload this episodeRecorded: 2022-05-02Published: 2022-05-22

Allmennlege Sjur Even Aunmo fikk sparken som fastlegevikar fordi han fortalte pasienter at COVID-19-vaksinen kan gi bivirkninger. Dette er noe han plikter å gjøre ifølge Pasient- og brukerrettighetsloven § 4. Aunmo har satt seg grundig inn i forskningen på disse vaksinene, og påpeker at de for det første er eksperimentelle på dette stadiet. Videre er det Pfizer selv som har finansiert sin studie, en ansatt fikk sparken fordi hun varslet om at blindingen (anonymiseringen) var brutt, personer har blitt tatt ut av studien uten at det er oppgitt noen god grunn og rådataene for studien er ikke offentliggjort. Selv har han sett flere bivirkninger, som kraftige menstruasjonsblødninger, hjerteproblemer og alvorlige nevrologiske bivirkninger. Han frykter at underrapportering kan medføre at bivirkningstallene fra Statens legemiddelverk er for lave. KILDER:› COVID-19 • https://clinicaltrials.gov/ct2/show/NCT04368728 • https://clinicaltrials.gov/ct2/show/NCT04470427 • Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine • Efficacy of the mRNA-1273 SARS-CoV-2 Vaccine at Completion of Blinded Phase • https://covid-nma.com/vaccines/variants/ • https://covid-nma.com/vaccines/index.php?search_by=1&search_input=1273&submit=Validate#moteur_recherche • How significant is the Ventavia scandal? • Covid-19: Researcher blows the whistle on data integrity issues in Pfizer's vaccine trial • CDC-vurdering av Modernas studie • https://www.bmj.com/company/newsroom/editors-call-for-covid-19-vaccine-and-treatment-data-to-be-available-for-public-scrutiny/ • https://www.nrk.no/norge/norges-forste-koronavaksine-settes-1.15304159, lest 20.3.22 • https://tidsskriftet.no/2021/05/originalartikkel/dodsfall-i-sykehjem-etter-covid-19-vaksine ◦ https://www.fhi.no/hn/helseregistre-og-registre/dodsarsaksregisteret/tall-for-covid-19-assosierte-dodsfall-i-dodsarsaksregisteret-i-2020/ ◦ https://legemiddelverket.no/Documents/Bivirkninger%20og%20sikkerhet/Rapporter%20og%20oversikter/Koronavaksiner/20211028%20Rapport%20over%20meldte%20bivirkninger%20av%20koronavaksine.pdf ◦ Surveillance for safety after immunization; vaccine adverse event reporting system (VAERS) - United States 1991-2001 ◦ Mandatory Reporting of Infectious Diseases by Clinicians ◦ Myopericarditis after vaccination, Vaccine Adverse Event Reporting System (VAERS), 1990–2018 ◦ https://www.nrk.no/livsstil/_-en-medisinsk-katastrofe-1.10880384 ◦ https://legemiddelverket.no/nyheter/bivirkninger-av-vaksiner-hva-lerte-vi-av-pandemien-i-2009#ble-det-meldt-noen-d%C3%B8dsfall? ◦ The illusion of evidence based medicine ‧ Amerikanske Centers for Disease Control om underrapportering ‧ Studie fra det medisinske tidsskriftet JAMA om underrapportering ‧ Studie fra det medisinske tidsskriftet Vaccine om underrapportering ‧ Fra det amerikanske registrerings-systemet VAERS om deres system ‧ Randomised Clinical Trials of COVID-19 Vaccines: Do Adenovirus-Vector Vaccines Have Beneficial Non-Specific Effects? ‧ Lancet 2022. Samlestudie RCT. Obs: Preprrint, ikke fagfallevurdert enda. Signifikant og stor forskjell mellom Pfizer/Moderna og svekket-virus-vaksiner.› FETT • Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis • Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73) • Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease • The effect of replacing saturated fat with mostly n-6 polyunsaturated fat on coronary heart disease: a meta-analysis of randomised controlled trials • Saturated Fats and Health: A Reassessment and Proposal for Food-Based Recommendations: JACC State-of-the-Art Review • http://dx.doi.org/10.1136/openhrt-2014-000196 • Fat or fiction: the diet-heart hypothesis | BMJ Evidence-Based Medicine • https://www.mn.uio.no/ibv/tjenester/kunnskap/plantefys/leksikon/h/herdet-fett.html • 4-Hydroxynonenal-Derived Advanced Lipid Peroxidation End Products Are Increased in Alzheimer's Disease • https://doi.org/10.1016/j.freeradbiomed.2006.07.021 ◦ Dietary stearic acid regulates mitochondria in vivo in humans - Nature Communications ◦ 33.9 10.17140/AFTNSOJ-1-123 Oxidation of Polyunsaturated Fatty Acids and its Impact on Food Quality and Human Health ◦ Dietary oxidized n-3 PUFA induce oxidative stress and inflammation: role of intestinal absorption of 4-HHE and reactivity in intestinal cells ◦ Effect of the Type of Frying Culinary Fat on Volatile Compounds Isolated in Fried Pork Loin Chops by Using SPME-GC-MS› STATINER • BMJ RCT sysrew/meta Statins for the primary prevention of cardiovascular disease: an overview of systematic reviews • The effect of statins on average survival in randomised trials, an analysis of end point postponement • JAMA RCT-meta 2010 - Statins and All-Cause Mortality in High-Risk Primary Prevention: A Meta-analysis of 11 Randomized Controlled Trials Involving 65 229 Participants • https://www.felleskatalogen.no/medisin/lipitor-upjohn-eesv-pfizer-560999 • https://www.felleskatalogen.no/medisin/zocor-organon-565655 • https://www.legemiddelhandboka.no/L8.15.1/Statiner • Statins - a call for transparent data - The BMJ • Statin Use and Risk of Diabetes Mellitus in Postmenopausal Women in the Women's Health Initiative› KJØTT • Effect of Lower Versus Higher Red Meat Intake on Cardiometabolic and Cancer Outcomes A Systematic Review of Randomized Trials • Total red meat intake of ≥0.5 servings/d does not negatively influence cardiovascular disease risk factors: a systemically searched meta-analysis of randomized controlled trials› KOLESTEROL • Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review • Inborn coagulation factors are more important cardiovascular risk factors than high LDL-cholesterol in familial hypercholesterolemia • PMID: 18277343 ApoB/ApoA1 ratio and subclinical atherosclerosis ◦ Cigarette smoking renders LDL susceptible to peroxidative modification and enhanced metabolism by macrophages ◦ Cigarette Smoking Potentiates Endothelial Dysfunction of Forearm Resistance Vessels in Patients With Hypercholesterolemia: Role of Oxidized LDL ◦ Passive Smoking Induces Atherogenic Changes in Low-Density Lipoprotein ◦ Smoking and smoking cessation—The relationship between cardiovascular disease and lipoprotein metabolism: A review ◦ Smoking and Cardiovascular Disease ◦ LDL biochemical modifications: a link between atherosclerosis and aging ◦ Association Between Circulating Oxidized LDL and Atherosclerotic Cardiovascular Disease: A Meta-analysis of Observational Studies› KARBOHYDRAT • https://www.helsedirektoratet.no/rapporter/anbefalinger-om-kosthold-ernaering-og-fysisk-aktivitet/Anbefalinger%20om%20kosthold%20ern%C3%A6ring%20og%20fysisk%20aktivitet.pdf/_/attachment/inline/2f5d80b2-e0f7-4071-a2e5-3b080f99d37d:2aed64b5b986acd14764b3aa7fba3f3c48547d2d/Anbefalinger%20om%20kosthold%20ern%C3%A6ring%20og%20fysisk%20aktivitet.pdf› DIABETES • JAMA WMI 2006Low-Fat Dietary Pattern and Risk of Cardiovascular DiseaseThe Women's Health Initiative Randomized Controlled Dietary Modification Trial – se side 661, økt hjerte/kar-risk sfa. Lavfett-diett • AmJourClinNutr WMI 2011 Effects of a low-fat dietary intervention on glucose, insulin, and insulin resistance in the Women's Health Initiative (WHI) Dietary Modification trial • AOCS Lipids (lavranket journal) Carbohydrate Restriction has a More Favorable Impact on the Metabolic Syndrome than a Low Fat Diet • Small Dense Low-Density Lipoprotein-Cholesterol Concentrations Predict Risk for Coronary Heart Disease- ArtThromVas prospektiv kohort • Glycation as an atherogenic modification of LDL : Current Opinion in Lipidology • Glycosylated low density lipoprotein is more sensitive to oxidation: implications for the diabetic patient? • Loss of Endothelial Glycocalyx During Acute Hyperglycemia Coincides With Endothelial Dysfunction and Coagulation Activation In Vivo› DIABETES-DEMENS • AgeingResearchRewiew 2019 sysrew/meta 144 prospektive studier – 58 % økt risiko demens • Int. Med. Journ. 2012 meta-analyse av prospektive kohorter dia-demens-risk 51 % økning demens • Lancet Neurology 2006, sysrew lavere evidensgrad. Risk of dementia in diabetes mellitus: a systematic review • Diabetes mellitus and the risk of dementia - The Rotterdam Study – prospektiv kohort • JDST 2008 Alzheimer's Disease is Type 3 Diabetes—Evidence Reviewed • MDPI 2015 Evaluating the Association between Diabetes, Cognitive Decline and Dementia • Ketone Bodies Promote Amyloid-β1–40 Clearance in a Human in Vitro Blood–Brain Barrier Model - 2020 • Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implication - 2018 • APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline - 2020› HJERTE- OG KAR-SYKDOM • 10.1001/jamacardio.2020.7073 Association of Lipid, Inflammatory, and Metabolic Biomarkers With Age at Onset for Incident Coronary Heart Disease in Women› PLANTE-ANTINÆRINGSSTOFF OG VERN • Food Chemistry 2008 Bioaccessibility of Ca, Mg, Mn and Cu from whole grain tea-biscuits: Impact of proteins, phytic acid and polyphenols • Phytate in foods and significance for humans: food sources, intake, processing, bioavailability, protective role and analysis. Mol Nutr Food Res. 2009 Sep;53 Suppl 2:S330-75. • Oxalate content of foods and its effect on humans • Lectins as plant defense proteins • Effects of wheat germ agglutinin on human gastrointestinal epithelium: Insights from an experimental model of immune/epithelial cell interaction • Ingestion of subthreshold doses of environmental toxins induces ascending Parkinsonism in the rat • Identification of intact peanut lectin in peripheral venous blood • Do dietary lectins cause disease? BMJ • Lectin binding of endometrium in women with unexplained infertility • Changes in organs and tissues induced by feeding of purified kidney bean (Phaseolus vulgaris) lectins • Insecticidal Activity of Plant Lectins and Potential Application in Crop Protection • Bound Lectins that Mimic Insulin Produce Persistent Insulin-Like Activities • Contribution of leptin receptor N-linked glycans to leptin binding • Potato lectin activates basophils and mast cells of atopic subjects by its interaction with core chitobiose of cell-bound non-specific immunoglobulin E • 3.0.CO;2-T Dietary lectins can induce in vitro release of IL-4 and IL-13 from human basophils • Secondary Oxalate Nephropathy: A Systematic Review • The effect of tea on iron absorption • PMID: 1862 Disler PB, Lynch SR, Torrance JD, et al. The mechanism of the inhibition of iron absorption by tea. The South African Journal of Medical Sciences. 1975 ;40(4):109-116. • Effects of saponins and glycoalkaloids on the permeability and viability of mammalian intestinal cells and on the integrity of tissue preparationsin vitro • The biological action of saponins in animal systems: a review • Small Amounts of Gluten in Subjects With Suspected Nonceliac Gluten Sensitivity: A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Trial ◦ Obs: Kapsler brukt i studien ble supplert av legemiddelfirmaet Giuliani, som lager glutenfritt brød.› LEKK TARM • Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines • Gliadin Induces an Increase in Intestinal Permeability and Zonulin Release by Binding to the Chemokine Receptor CXCR3 • AmJourClinNu 2009 Cancer incidence in vegetarians: results from the European Prospective Investigation into Cancer and Nutrition (EPIC-Oxford) • FODMAP diet modulates visceral nociception by lipopolysaccharide-mediated intestinal inflammation and barrier dysfunction • 73.3 10.12688/f1000research.20510.1 All disease begins in the (leaky) gut: role of zonulin-mediated gut permeability in the pathogenesis of some chronic inflammatory diseases› LAVKARB • Effects of Low-Carbohydrate vs Low-Fat Diets on Weight Loss and Cardiovascular Risk Factors • BritJourNutr 2013 RCT-meta Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials • AnnIntMed 2004 A Low-Carbohydrate, Ketogenic Diet versus a Low-Fat Diet To Treat Obesity and Hyperlipidemia: A Randomized, Controlled Trial • JAMAIntMed A Randomized Trial of a Low-Carbohydrate Diet vs Orlistat Plus a Low-Fat Diet for Weight Loss • NEJM RCT 2006 A Low-Carbohydrate as Compared with a Low-Fat Diet in Severe Obesity • Short-term effects of severe dietary carbohydrate-restriction advice in Type 2 diabetes—a randomized controlled trial • Effects of a low carbohydrate diet on energy expenditure during weight loss maintenance: randomized trial • Effects of a low-carbohydrate diet on weight loss and cardiovascular risk factor in overweight adolescents • Comparison of the Atkins, Zone, Ornish, and LEARN Diets for Change in Weight and Related Risk Factors Among Overweight Premenopausal WomenThe A TO Z Weight Loss Study: A Randomized Trial • Efficacy and Safety of a High Protein, Low Carbohydrate Diet for Weight Loss in Severely Obese Adolescents • Long-Term Effects of a Novel Continuous Remote Care Intervention Including Nutritional Ketosis for the Management of Type 2 Diabetes: A 2-Year Non-randomized Clinical Trial› FRUKTOSE • JourHepatology 2021 Fructose- and sucrose- but not glucose-sweetened beverages promote hepatic de novo lipogenesis: A randomized controlled trial • Effects of fructose restriction on liver steatosis (FRUITLESS); a double-blind randomized controlled trial› KETOGENISITET/KREFT • https://oslo-universitetssykehus.no/behandlinger/pet-undersokelse • https://stanfordhealthcare.org/medical-tests/p/pet-scan/what-to-expect.html • https://www.sciencedirect.com/topics/medicine-and-dentistry/warburg-effect • The Warburg Effect: How Does it Benefit Cancer Cells? • NutrCanc 2019 Feasibility, Safety, and Beneficial Effects of MCT-Based Ketogenic Diet for Breast Cancer Treatment: A Randomized Controlled Trial Study • Dietary Glycemic Load and Cancer Recurrence and Survival in Patients with Stage III Colon Cancer: Findings From CALGB 89803 • Ketogenic diet in cancer therapy› IATROGEN SKADE • https://tidsskriftet.no/2000/10/kronikk/uheldige-hendelser-i-helsetjenesten-forebygging-og-handteringOpptaksdato: 2022-05-02Publiseringsdato: 2022-05-22Last ned episoden

Get educated and motivated to eat more vegetables, especially green vegetables. This video covers statistics research and practical tips to improving health, energy, and well being, while promoting longevity and disease prevention and reversal. Looking for personalized plans and professional accountability with transitioning to a plant based diet? Click here to apply for a free initial consultation with me: https://form.jotform.com/193528759357172 Hit me up, would love to connect! Instagram: https://www.instagram.com/vitamin.katie/ Website: https://vitaminkatie.com/ Facebook: https://www.facebook.com/ktreinesy Email: k.reines1@gmail.com Randy Jacobs: https://www.lifeforcegrowers.com/ Use discount code VITAMINKATIE to save $40 on your NutriSense Continuous Glucose Monitor: https://www.nutrisense.io/ Sources sited: CDC Fruit & Vegetable Intakes: https://www.cdc.gov/mmwr/volumes/71/wr/mm7101a1.htm?s_cid=mm7101a1_w Consumption of fruit and vegetable and risk of coronary heart disease: a meta-analysis of prospective cohort studies: https://pubmed.ncbi.nlm.nih.gov/25662075/ Cruciferous vegetables intake and the risk of colorectal cancer: a meta-analysis of observational studies: https://pubmed.ncbi.nlm.nih.gov/23211939/ Fruit, vegetables, and colorectal cancer risk: the European Prospective Investigation into Cancer and Nutrition: https://academic.oup.com/ajcn/article/89/5/1441/4596864?login=false Fruit and Vegetable Intake and Mortality, Results From 2 Prospective Cohort Studies of US Men and Women and a Meta-Analysis of 26 Cohort Studies: https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.120.048996 The beneficial effects of Brassica vegetables on human health (20-40% reduced breast cancer): https://pubmed.ncbi.nlm.nih.gov/23631258/ Effects of chlorophyll and chlorophyllin on low-dose aflatoxin B(1) pharmacokinetics in human volunteers: https://pubmed.ncbi.nlm.nih.gov/19952359/ Efficacy of SXN in the Treatment of Iron Deficiency Anemia: A Phase IV Clinical Trial: https://pubmed.ncbi.nlm.nih.gov/30941201/

Vitamin K shows evidence of brain benefits  Study suggests a biological pathway through which vitamin K may help ward off dementia  AlMaarefa University(Saudi Arabia), April 5, 2022 In a new study conducted in rats, scientists report evidence that vitamin K could help protect against aging-related cognitive declines associated with Alzheimer's disease and other forms of dementia. Vitamin K2 demonstrated very promising impact in hindering aging-related behavioral, functional, biochemical and histopathological changes in the senile aging brain. Vitamin K2 can be proposed to be a promising approach to attenuate age-related disorders and preserve cognitive functions in aging individuals. The researchers used validated tests including a maze, swim test and sociability test to assess the rats' cognitive functioning and depressive-like and anxiety behavior. These tests revealed that rats that received MK-7 performed better than those that did not. Vitamin K supplementation was associated with reduced evidence of cognitive impairment, depression and anxiety, along with improved spatial memory and learning ability. (Next) Vegetarian Diet Reduces Risk Of Heart Disease By A Third University of Oxford, March 30, 2022    A vegetarian diet can reduce a person's risk of heart disease by a third. Vegetarians have a 32% lower risk of hospitalization or death from cardiovascular disease than people who consume meat and fish. The study is the largest yet to compare cardiovascular disease rates between vegetarians and meat eaters. The experts analyzed nearly 45,000 participants (34% were vegetarian) from England and Scotland who signed up for the European Prospective Investigation into Cancer and Nutrition (EPIC)-Oxford study. (NEXT) Meditation builds brain cells, Harvard study shows proof Harvard University, April 2, 2022 Research has now demonstrated that meditation builds brain cells and increases gray matter in the brain. Using magnetic imaging (MRI), Harvard researchers found that meditation produced physiological changes in the brain's gray matter. Some areas in the brains of the study participants thickened after only eight weeks of mindfulness practice. Study participants reported feeling less stressed after the eight-week period. MRI scans revealed decreased gray matter in the amygdalae and increased gray matter in the hippocampus. The amygdalae are the parts of the brain that help the body deal with anxiety and stress and controls the “fight or flight” mechanism. The hippocampus, which showed an increase in gray-matter density, is the area of the brain that controls memory, learning, self-awareness, introspection and compassion. (NEXT) Artificial sweeteners linked with a 13% higher risk of cancer Sorbonne Paris Nord University, March 31, 2022 A large new observational study has found an association between the consumption of artificial sweeteners, particularly aspartame and acesulfame-K, and cancer. The study found a 13% higher risk of cancer in general, with the highest likelihood of developing breast cancer and cancers related to obesity, for people consuming large quantities of artificial sweeteners. The researchers analyzed the histories of 102,865 adults participating in the ongoing NutriEnt-Santé studyTrusted Source that began collecting data in 2009. Participants were followed for the new research over an average of 7.8 years. Senior investigator and director of EREN Dr. Mathilde Touvier said to MNT: “We performed analyses for the ‘total of artificial sweeteners' overall (i.e., the sum of acesulfame-K, aspartame, sucralose, cyclamates, saccharin, steviol glycosides, and salt of aspartame-acesulfame), and then separately for the most represented artificial sweeteners in the cohort (i.e., acesulfame-K, aspartame, and sucralose).” Looking deeper into the greater risk of Aspartame and acesulfame-K, Dr. Touvier explained, “It should be noted that aspartame and acesulfame-K were by far the most frequently consumed artificial sweeteners.” (NEXT) Israeli Study: Your Cell Phone Is Killing Your Sperm Technion-Israel Institute of Technology and Carmel Medical Center (Israel), April 2, 2022 Over the years, science has thoroughly documented the global decline in male fertility, which has been ongoing since the 1940s. Several possible culprits have been blamed such exposure to pesticides, estrogen-mimicking chemicals, and sedentary lifestyles. However, a team of Israeli scientists has found another possible environmental cause. Researchers at Haifa's Technion- Israel Institute of Technology and Carmel Medical Center, conducted a study involving 106 men who were given a semen analysis. They have found that men who wear their cell phones in their pants pockets, have significantly higher rates of abnormal sperm. 47% of men who stored their cell phones in their pants had abnormal sperm, compared to just 11% for the average male. But keeping a cell phone near the groin wasn't the only contributing factor to poor fertility. Both talking on the phone for more than an hour a day and using it while it was charging, was also linked to abnormal sperm counts. Videos Clips:  Doctor Exposes The Corruption Of Food Science (Pt. 2) | Dr. Mark Hyman | LIFESTYLE  (8:55 Long) 2. FAUCI In His Own Words  3. “is about something called furries.” 4. Ben Swann : Hunter Biden invested in and raised money for Bio Labs  5. An Economic Hit Man Confesses and Calls to Action | John Perkins | TEDxTraverseCity (18:35 Long)     Articles : No Significant Difference in Viral Load Between Vaccinated and Unvaccinated, Asymptomatic and Symptomatic Groups When Infected with SARS-CoV-2 Delta Variant Freedom and Ivermectin prevail Farewell, University of California WSJ Misleads Public on Ivermectin, Ignores Latest Revelations About ‘Hidden Author' Who Undermined Its Efficacy The great Aids scam – a dry run for Covid Revisiting pharmacological potentials of Nigella sativa seed: A promising option for COVID-19 prevention and cure

In this episode, we're taking a high-level look at various studies comparing the nutritional quality of different dietary patterns. We'll unpack what the research says about the healthfulness of vegetarian and vegan diets, as well as the standard American diet.   Research links: Food Groups Schwingshackl L, Schwedhelm C, Hoffmann G, Lampousi AM, Knüppel S, Iqbal K, Bechthold A, Schlesinger S, Boeing H. Food groups and risk of all-cause mortality: a systematic review and meta-analysis of prospective studies. Am J Clin Nutr. 2017 Jun;105(6):1462-1473. doi: 10.3945/ajcn.117.153148. Epub 2017 Apr 26. PMID: 28446499. Beyond Meatless Le LT, Sabaté J. Beyond meatless, the health effects of vegan diets: findings from the Adventist cohorts. Nutrients. 2014 May 27;6(6):2131-47. doi: 10.3390/nu6062131. PMID: 24871675; PMCID: PMC4073139. Orlich and Fraser Study: Orlich MJ, Singh PN, Sabaté J, Jaceldo-Siegl K, Fan J, Knutsen S, Beeson WL, Fraser GE. Vegetarian dietary patterns and mortality in Adventist Health Study 2. JAMA Intern Med. 2013 Jul 8;173(13):1230-8. doi: 10.1001/jamainternmed.2013.6473. PMID: 23836264; PMCID: PMC4191896. Meat Consumption and Mortality: Rohrmann S, Overvad K, Bueno-de-Mesquita HB, Jakobsen MU, Egeberg R, Tjønneland A, Nailler L, Boutron-Ruault MC, Clavel-Chapelon F, Krogh V, Palli D, Panico S, Tumino R, Ricceri F, Bergmann MM, Boeing H, Li K, Kaaks R, Khaw KT, Wareham NJ, Crowe FL, Key TJ, Naska A, Trichopoulou A, Trichopoulos D, Leenders M, Peeters PH, Engeset D, Parr CL, Skeie G, Jakszyn P, Sánchez MJ, Huerta JM, Redondo ML, Barricarte A, Amiano P, Drake I, Sonestedt E, Hallmans G, Johansson I, Fedirko V, Romieux I, Ferrari P, Norat T, Vergnaud AC, Riboli E, Linseisen J. Meat consumption and mortality--results from the European Prospective Investigation into Cancer and Nutrition. BMC Med. 2013 Mar 7;11:63. doi: 10.1186/1741-7015-11-63. PMID: 23497300; PMCID: PMC3599112.   Product links: Picky Club

Recently you may have heard the term "Blue Zone" trending across the health and wellness world. This is due to a new theory on longevity based on the "longest living" cultures in the world.  In today's episode, Zane Griggs gives breaks down the facts and data around these regions and schools of thought behind the Blue Zone lifestyle.  LINKS: Nutrition for the Japanese Elderly https://pubmed.ncbi.nlm.nih.gov/1407826/ Male longevity in Sardinia, a review of historical sources supporting a causal link with dietary factor https://pubmed.ncbi.nlm.nih.gov/25369832/ Nicoya Peninsula: High longevity region for elderly males, 2014 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241350/ Mortality in vegetarians and comparable non vegetarians in the UK https://pubmed.ncbi.nlm.nih.gov/26657045/ Vegetarianism: What the science tells us Comparison of vegetarian and non vegetarian adventists https://www.westonaprice.org/health-topics/abcs-of-nutrition/vegetarianism-what-the-science-tells-us/ Cancer incidence in vegetarians: results from the European Prospective Investigation into Cancer and Nutrition (EPIC-Oxford) https://pubmed.ncbi.nlm.nih.gov/19279082/ Nutrition and Health – The Association between Eating Behavior and Various Health Parameters: A Matched Sample Study https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917888/   Zane's Links: Get organic keto meals delivered to your door!! https://trifectanutrition.llbyf9.net/zane ReLyte Electrolytes by Redmond Real Salt https://shop.redmond.life?afmc=Zane Follow me on Instagram: https://www.instagram.com/zanegriggsfitness   QUICK EPISODE SUMMARY: The Blue Zones around the world Book recommendation for Nourishing Diets Eating habits around the world The low-fat narrative is unraveling  The diet-heart hypothesis Cardiovascular mortality risks for animal-based vs plant-based eaters Why are people dismissing the facts? Understanding what the poison is 

In our first podcast I asked Joel to provide any interventional studies showing harm from red meat, or any unprocessed meat. He was unable to provide these studies at that time, or in the 2 weeks that followed before I released our podcast debate. After that time he wrote a blog post with his thoughts in response to many of the points I raised during the podcast, providing what he believed to be studies corroborating his points. This podcast is a solo-cast in which I respond to his blog post points to show some counter points and point out that I still do not believe his case for plant-based diets is able to be substantiated. I’ve reached out to Joel to see if he will come back on the podcast for a part two, but he has not yet responded. Will keep you posted! #theremembering Time stamps: 0:10:07 Did Dr. Joel Furhman ever send me those studies that demonstrated red meat has a damaging affect on humans? 0:12:42 Reviewing Dr. Joel Fuhrman's blog post regarding plant foods vs animal foods 0:18:27 Association of animal and plant protein intake with all-cause and cause-specific mortality 0:23:17 Meat intake and cause-specific mortality: a pooled analysis of asian prospective cohort studies 0:24:27 Mortality in british vegetarians 0:28:07 Physical activity patterns and biomarkers of cardiovascular disease risk in hunter-gatherers 0:29:25 Increased lean red meat intake does not elevate markers of oxidative stress and inflammation in humans 0:29:47 Isocaloric diets high in animal or plant protein reduce liver fat and inflammation in individuals with type 2 diabetes 0:30:08 Effects of plant and animal high protein diets on immune-inflammatory biomarkers: a 6-week intervention trial 0:30:37 Changes in Dietary Fat Intake Alter Plasma Levels of Oxidized Low-Density Lipoprotein and Lipoprotein(a) 0:34:47 Cancer incidence in vegetarians: results from the European Prospective Investigation into Cancer and Nutrition (EPIC-Oxford) 0:37:14 Mortality in vegetarians and comparable nonvegetarians in the United Kingdom 0:38:47 Beef tallow increases apoptosis and decreases aberrant crypt foci formation relative to soybean oil in rat colon 0:41:12 Potential effects of reduced red meat compared with increased fiber intake on glucose metabolism and liver fat content: a randomized and controlled dietary intervention study 0:44:27 Validity of U.S. nutritional surveillance:National Health and Nutrition Examination Survey caloric energy intake data, 1971-2010 0:47:47 Effect of Legumes as Part of a Low Glycemic Index Diet on Glycemic Control and Cardiovascular Risk Factors in Type 2 Diabetes Mellitus - A Randomized Controlled Trial 0:50:37 Bean Consumption Is Associated with Greater Nutrient Intake, Reduced Systolic Blood Pressure, Lower Body Weight, and a Smaller Waist Circumference in Adults: Results from the National Health and Nutrition Examination Survey 1999-2002 0:57:52 The actions of exogenous leucine on mTOR signalling and amino acid transporters in human myotubes 1:01:37 Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population 1:05:27 Nutrition for the Japanese elderly 1:07:07 The capacity of foodstuffs to induce innate immune activation of human monocytes in vitro is dependent on food content of stimulants of Toll-like receptors 2 and 4 1:12:52 Fish oil attenuates omega-6 polyunsaturated fatty acid-induced dysbiosis and infectious colitis but impairs LPS dephosphorylation activity causing sepsis 1:16:07 Red meat and colon cancer: A review of mechanistic evidence for heme in the context of risk assessment methodology 1:19:32 Red meat enhances the colonic formation of the DNA adduct O6-carboxymethyl guanine: implications for colorectal cancer risk 1:24:07 Assessment of Causal Direction Between Gut Microbiota-Dependent Metabolites and Cardiometabolic Health: A Bidirectional Mendelian Randomization Analysis 1:25:27 Diabetes is Associated with Higher Trimethylamine N-oxide Plasma Levels 1:26:22 Trimethylamine and Trimethylamine N-Oxide, a Flavin-Containing Monooxygenase 3 (FMO3)-Mediated Host-Microbiome Metabolic Axis Implicated in Health and Disease 1:35:37 Obesity is associated with hypothalamic injury in rodents and humans 1:36:07 Dysregulation of Hypothalamic Gene Expression and the Oxytocinergic System by Soybean Oil Diets in Male Mice 1:36:37 Animal source foods: Sustainability problem or malnutrition and sustainability solution? Perspective matters Sponsors: Heart & Soil: www.heartandsoil.co White Oak Pastures: www.Whiteoakpastures.com, use code: CarnivoreMD for 10% off your first order Belcampo: www.belcampo.com use code: CarnivoreMD for 20% off your order BluBlox: Blublox.com, use CarnivoreMD for 15% your order The Cold Plunge: TheColdPlunge.com, use code CarnivoreMD for $111 off your cold plunge

Anti-aging compound improves muscle glucose metabolism in people Washington University School of Medicine in St. Louis, April 26, 2021   A natural compound previously demonstrated to counteract aspects of aging and improve metabolic health in mice has clinically relevant effects in people, according to new research at Washington University School of Medicine in St. Louis. A small clinical trial of postmenopausal women with prediabetes shows that the compound NMN (nicotinamide mononucleotide) improved the ability of insulin to increase glucose uptake in skeletal muscle, which often is abnormal in people with obesity, prediabetes or Type 2 diabetes. NMN also improved expression of genes that are involved in muscle structure and remodeling. However, the treatment did not lower blood glucose or blood pressure, improve blood lipid profile, increase insulin sensitivity in the liver, reduce fat in the liver or decrease circulating markers of inflammation as seen in mice. The study, published online April 22 in the journal Science, is the first randomized clinical trial to look at the metabolic effects of NMN administration in people. Among the women in the study, 13 received 250 mg of NMN orally every day for 10 weeks, and 12 were given an inactive placebo every day over the same period. "Although our study shows a beneficial effect of NMN in skeletal muscle, it is premature to make any clinical recommendations based on the results from our study," said senior investigator Samuel Klein, MD, the William H. Danforth Professor of Medicine and Nutritional Science and director of the Center for Human Nutrition. "Normally, when a treatment improves insulin sensitivity in skeletal muscle, as is observed with weight loss or some diabetes medications, there also are related improvements in other markers of metabolic health, which we did not detect in our study participants." The remarkable beneficial effects of NMN in rodents have led several companies in Japan, China and in the U.S. to market the compound as a dietary supplement or a neutraceutical. The U.S. Food and Drug Administration is not authorized to review dietary supplement products for safety and effectiveness before they are marketed, and many people in the U.S. and around the world now take NMN despite the lack of evidence to show clinical benefits in people. The researchers studied 25 postmenopausal women who had prediabetes, meaning they had higher than normal blood sugar levels, but the levels were not high enough to be diagnosed as having diabetes. Women were enrolled in this trial because mouse studies showed NMN had the greatest effects in female mice. NMN is involved in producing an important compound in all cells, called nicotinamide adenine dinucleotide (NAD). NAD plays a vital role in keeping animals healthy. Levels of NAD decline with age in a broad range of animals, including humans, and the compound has been shown to contribute to a variety of aging-associated problems, including insulin resistance in studies conducted in mice. Supplementing animals with NMN slows and ameliorates age-related decline in the function of many tissues in the body.  Co-investigator Shin-ichiro Imai, MD, PhD, a professor of developmental biology and of medicine who has been studying NMN for almost two decades and first reported on its benefits in mice said, "This is one step toward the development of an anti-aging intervention, though more research is needed to fully understand the cellular mechanisms responsible for the effects observed in skeletal muscle in people." Insulin enhances glucose uptake and storage in muscle, so people who are resistant to insulin are at increased risk for developing Type 2 diabetes. But the researchers caution that more studies are needed to determine whether NMN has beneficial effects in the prevention or management of prediabetes or diabetes in people. Klein and Imai are continuing to evaluate NMN in another trial involving men as well as women.     N-acetylcysteine for depression in adolescents and young adults at risk for bipolar disorder University of Cincinnati, April 23, 2021 According to news reporting originating from Cincinnati, Ohio, by NewsRx correspondents, research stated, “To investigate the mechanism of action of N-acetylcysteine (NAC) in depressive symptoms in young individuals at familial risk for bipolar disorder. We conducted an 8-week open label clinical trial of NAC 2400 mg/days in 15-24 years old depressed offspring of a bipolar I disorder parent, with baseline and endpoint proton magnetic resonance spectroscopy acquired within the left ventrolateral prefrontal cortex (VLPFC).” Our news editors obtained a quote from the research from the University of Cincinnati, “Nine participants were enrolled and finished the study. NAC significantly improved depressive and anxiety symptom scores, and clinical global impression (all p< .001). There was a non-significant reduction in glutamate levels in the left VLPFC. Reduction in depressive symptom scores was positively associated with reduction in glutamate levels in the left VLPFC (p = .007).” According to the news editors, the research concluded: “This pilot study suggests that NAC might be efficacious for depressive symptoms in at-risk youth, and that its mechanism of action involves the modulation of glutamate in the left VLPFC.” This research has been peer-reviewed.     Soda consumption linked to accelerated aging and increased mortality risk University of California at San Francisco, April 26, 2021 A recent study by researcher from the University of California, San Francisco says that drinking soda can increase the risk of all-cause mortality and accelerate aging. The findings build on mounting evidence of the adverse effects drinking soda and other sugary beverages have on the body, which include obesity, Type 2 diabetes, heart disease, kidney disease, non-alcoholic fatty liver disease, dental caries and gout. The team collated data from the National Health and Examination Surveys, an annual program for assessing the health and nutrition of American adults and children. They gathered data from over 5,300 participants between 1999 and 2002, all of whom had no history of diabetes or cardiovascular disease.  In particular, they looked at stored DNA data from the participants – measuring telomere length and comparing it with their consumption of sugar-sweetened soda. The researchers found that those who regularly drank sugar-sweetened soda had shorter telomeres than those who didn’t. Research has shown that telomeres have been previously associated with lifespan. Having shorter telomere length, for instance, has been linked to cardiovascular disease, diabetes and even certain types of cancer. The team reported in their study that consuming even just eight ounces of soda every day can accelerate aging by nearly two years. Meanwhile, 20 ounces of soda can accelerate aging by up to 4.6 years when consumed daily. In fact, drinking sugar-sweetened soda can reduce telomere length at a rate similar to smoking. The UCSF study is also the first to link regular consumption of sugar-sweetened soda to telomere shortening. According to study co-author Elissa Epel, drinking sugar-sweetened soda adds strain to the body by metabolizing these sugars and accelerates cellular aging in tissues. “This finding held regardless of age, race, income and education level. Telomere shortening starts long before disease onset,” Epel added. ” Although we only studied adults here, it is possible that soda consumption is associated with telomere shortening in children, as well.” Sugary sodas linked to rising all-cause deaths In another study, European experts revealed that drinking sugary sodas and other sweetened drinks increases the risk of all-cause deaths. The researchers collected data from more than 450,000 individuals enrolled in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, a large-scale cohort study for biochemical and genetic markers for cancer and other chronic diseases. A follow-up revealed that more than 40,000 participants from the original study had already died. Using their data, the team found a strong link between regular soda consumption and all-cause mortality. Those who regularly drank more than two glasses of sugary drinks increased their risk of dying from circulatory diseases, while those who drank at least one glass of sugary drinks increased their risk of dying from digestive diseases and Parkinson’s disease. “Our results … provide additional support for the possible adverse health effects of sugar-sweetened soft drinks and to replace them with other healthier beverages, preferably water,” explained co-author Neil Murphy. “For artificially-sweetened soft drinks, we now need a better understanding of the mechanisms that may underlie this association and research such as ours will hopefully stimulate these efforts.” The findings appeared in JAMA Internal Medicine.     Curcumin concoction could combat colitis: Study Baylor University, April 25, 2021 A formula that blends curcumin and turmeric oils can prove effective against the activity and inflammatory burden of colitis, a study has determined. Published in Nature Scientific Reports, the study identifies the efficacy of a specific curcumin preparation containing essential turmeric oils (ETO-curcumin) in reducing colitis symptoms. These turmeric oils, aromatic-tumerones (ar-tumerones), alpha-turmerones, beta-turmerones, alpha-santalene and aromatic curcumene, appear to be responsible for an anti-inflammatory and anti-oxidant action, the study suggests. The combination also appeared to exert higher bioactivity than stand-alone curcumin – a feature that could prove valuable in using turmeric for other intestinal conditions. “The therapeutic benefits of turmeric can be attained at its best by combining curcumin with turmerone, an active compound derived from essential oil of turmeric,” said P.J. Kunjachan, chairman and managing director for Arjuna Natural Extracts “This new finding provides our customers an added value for promoting their BCM-95-based formulations in an increasingly crowded curcumin market,” added Dr Benny Antony, joint managing director for Arjuna. BCM-95 often combines curcumin with other turmeric compounds as its poor bioavailability has been cited as a barrier to its use in other disorders. Obstacles are not limited to curcumin's chemical properties. Despite the 17 claims for its anti-inflammatory and digestive health properties, there are currently no approved health claims for curcumin in the EU. These claims are featured on the 2000+ list of on-hold botanical claims yet to be processed by the European Food Safety Authority (EFSA). As well as Arjuna, other manufacturers with an interest in curcumin include herbal manufacturers Sabinsa and Italian botanicals firm Indena. Led by Dr Shusuke Toden, research associate from Baylor University in the US, the trial compared ETO-curcumin preparations  against standard curcumin at three specific doses (0, 5, 25 or 50 milligrams per kilogram (mg/kg)). These doses were administered to an animal model with induced colitis for seven days. The research team found that ETO-curcumin improved disease activity index (DAI) dose-dependently, while the anti-inflammatory efficacy of standard curcumin remained constant. “This suggests that ETO-curcumin may provide superior anti-inflammatory efficacy compared to standard curcumin,” the study explained. “ETO-curcumin associated anti-inflammatory effects were particularly pronounced at higher doses.” Further findings revealed that anti-inflammatory proteins produced included IL-10 and IL-11 as well as FOXP3, which increased in number in the colon by ETO-curcumin.   Study examines association between lifestyle patterns and BMI in early childhood Results support obesity prevention efforts early in life Deakin University (Australia), April 26, 2021   A new Australian study reveals that changes in lifestyle patterns were longitudinally associated with concurrent changes in body mass index (BMI) z scores, and maternal pre-pregnancy BMI, maternal dietary patterns and television viewing time are significant determinants, according to a paper published online in Obesity, The Obesity Society's (TOS) flagship journal. This is the first study that used multi-trajectory modeling to examine the longitudinal relationship between concurrent changes in lifestyle patterns and BMI z scores in early childhood.  "The findings will inform early childhood obesity prevention intervention and policy, and will be of great interest to pediatricians, researchers, policymakers and the general public," said Miaobing Zheng of the Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, in Geelong, Australia. Zheng is the corresponding author of the study.  Experts explain that longitudinal studies investigating the association between lifestyle patterns and obesity in children are scarce. An association between a healthy lifestyle pattern and lower obesity risk has, however, been previously reported in a few cross-sectional studies. In the present study, the co-occurrence of stable healthy lifestyle patterns along with a concurrent normal BMI z score trajectory of one unit from 18 to 60 months in about half of the children provides new longitudinal evidence supporting that children with healthy lifestyles were more likely to concurrently have normal BMI z score development.  Data of 439 children were used from the Melbourne Feeding Activity and Nutrition Trial (InFANT) program. This longitudinal cohort of children commenced in 2008 as a 15-month parent-focused cluster randomized controlled trial aiming to reduce obesity risk behaviors in children until 18 months. Additional follow-ups without interventions occurred for children aged 42 and 60 months. Multi-trajectory modeling identified groups of children following similar lifestyle patterns and BMI z score trajectories and multi-nomial logistic regression assessed the determinants of the trajectory groups.  Three trajectory groups of child lifestyle patterns and BMI z scores were identified and distinguished, showing a mixture of healthy and unhealthy lifestyle behaviors and BMI zscores. Compared to Groups 1 "Unhealthy lifestyle pattern, Low BMI z" and 3 "Unhealthy lifestyle pattern, High BMI z", Group 2 "Healthy lifestyle pattern, Mid BMI z" revealed the most distinctive trajectories across lifestyle patterns and BMI z scores. Group 2 comprised nearly 53 percent of children and followed a stable and low trajectory for an unhealthy lifestyle pattern characterized by energy-dense and nutrient poor discretionary food consumption and television viewing time and a high and rising trajectory for a healthy lifestyle pattern of fruit and vegetable intakes and time outdoors, along with a mean BMI z score of +1 unit over time. Groups 1 and 3 shared similar high trajectories for an unhealthy lifestyle pattern of discretionary food consumption and television viewing time, and low trajectories for a healthy lifestyle pattern of fruit and vegetable intakes and time outdoors. The two groups however differed in BMI z score trajectories, showing stable patterns but at mean scores of 0 and +2 units, respectively. Child sex, breastfeeding duration and maternal physical activity were not associated with the identified trajectory groups. The study's authors note that the co-occurrence of stable lifestyle patterns and BMI z score trajectories in early childhood highlight the importance of initiating lifestyle obesity prevention early in life, and such interventions could target both children and the mother. A multi-behavior approach to simultaneously target healthy diet, physical activity and sedentary behaviors could be adapted. "Young children learn by imitating that which they see daily. There is no doubt that children copy the behaviors observed in the presence of parents: healthy and unhealthy," said Liliana Aguayo, PhD, MPH, a childhood obesity expert, TOS member and research assistant professor from the Hubert Department of Global Health at Emory University in Atlanta, Ga. "Evidence from this study highlights the importance of early childhood as a critical period for development of obesity. More research is needed to identify effective approaches to simultaneously address parent and child health behaviors." Aguayo was not associated with the research.     DDT exposure in grandmothers linked to obesity, earlier periods in granddaughters Young women today may face increased health risks linked to breast cancer due to effects from the banned toxic pesticide lasting over three generations University of California at Davis, April 16, 2021 In the first study to report on the health effects of exposure to a toxic environmental chemical over three human generations, a new study has found that granddaughters whose grandmothers were exposed to the pesticide DDT have higher rates of obesity and earlier first menstrual periods. This may increase the granddaughters' risk for breast cancer as well as high blood pressure, diabetes and other cardiometabolic diseases.  The research by the Public Health Institute's Child Health and Development Studies (CHDS) and the University of California at Davis was published today in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research. It suggests that effects from the pesticide DDT -- despite being banned in the U.S. nearly 50 years ago -- may contribute to the falling age of first periods and increases in obesity rates among young women today. The study found that the risk of obesity in young adult granddaughters was 2 to 3 times greater when their grandmothers (who were not overweight) had higher levels of o,p'-DDT (a contaminant of commercial DDT) in their blood during or just after pregnancy. Granddaughters were twice as likely to have earlier first menstrual periods when their grandmothers had higher o,p'-DDT blood levels. DDT and its related chemicals, including o,p'-DDT, are known to be endocrine disrupting chemicals, compounds that can alter and interfere with natural hormones that are essential for development.  "We already know that it's nearly impossible to avoid exposures to many common environmental chemicals that are endocrine disruptors. Now our study shows for the first time in people that environmental chemicals like DDT may also pose health threats to our grandchildren," said Barbara Cohn, director of CHDS and senior author of the study. "In combination with our on-going studies of DDT effects in the grandmother's and mother's generations, our work suggests we should take precautionary action on the use of other endocrine disrupting chemicals, given their potential to affect generations to come in ways we cannot anticipate today."  The Child Health and Development Studies is a unique project that has followed 20,000 pregnant women and their families for more than 60 years. CHDS enrolled and began following pregnant women in the Bay Area between 1959 and 1967, a time of high pesticide use before DDT was banned in 1972. These "founding grandmothers" in the study gave blood samples at each trimester during pregnancy and one sample shortly after birth. The blood samples were tested for levels of DDT and its related chemicals, including active ingredients, contaminants and their metabolites. The study today focused on o,p'-DDT as it has previously been linked to breast cancer, obesity and other harmful health effects in daughters, and is believed to be the most sensitive biomarker for exposures before and immediately after birth. Since granddaughters' exposure would occur via their mothers' in utero egg cell development, o,p'-DDT levels are a potential predictor of granddaughters' exposure outcomes.  "These data suggest that the disruption of endocrine systems by DDT initiates in immature human eggs, decades before the eggs are fertilized," said Michele La Merrill, associate professor at UCD who was co-lead author of the study. The CHDS study included interviews, home visits and questionnaires from the daughters and granddaughters of the original enrollees. During home visits, blood pressure and height and weight measurements were taken. The study today is based on 365 adult granddaughters who completed questionnaires, participated in a home visit, had available DDT measures from grandmothers' serum, and (for 285 of them) had available information on body mass index (BMI) in all three generations. Information on the age of first period for all three generations was available from 235 granddaughters. Previous CHDS studies have shown that mothers' DDT exposure during pregnancy or immediately after birth correlates with increased daughters' risk of breast cancer and the prevalence of breast cancer risk factors, including obesity, among adult daughters. Other prior studies have linked DDT exposure to birth defects, reduced fertility and an increased risk of diabetes. A commentary in the journal Reproductive Toxicology last year called CHDS "a national treasure that keeps on giving" and noted that "There are no other U.S. studies as well defined, sampled, and followed as the CHDS....The CHDS provides unique and essential value in understanding health effects of environmental exposures as they relate to life-stage sensitivity."       Capsaicin analog could help treatment-resistant lung cancer Small cell lung cancer cells exposed to synthetic analog of chili pepper compound responded better to chemotherapy Marshall University, April 27, 2021 A new study found that non-pungent synthetic analog of capsaicin -- the compound that makes chili peppers hot -- made small cell lung cancer cells more responsive to treatment. Small cell lung cancer is a very aggressive form of cancer with a low survival rate.  Cisplatin-based combination chemotherapy is typically the first-line treatment for small cell lung cancer patients. Although patients initially respond very well to this chemotherapy, the tumor usually comes back within a year in a form that doesn't respond to treatments. Patients with relapsed small cell lung cancer have very few treatment options.  "Irinotecan is the only FDA approved second-line drug for small cell lung cancer, but less than 3% of patients respond to it," said research team leader Piyali Dasgupta, PhD, from Marshall University. "Therefore, agents that improve the anti-cancer activity of irinotecan would be of great value to these patients." Jamie Friedman, a former doctoral student in Dasgupta's lab will present the new findings at the American Society for Investigative Pathology annual meeting during the virtual Experimental Biology (EB) 2021 meeting, to be held April 27-30.  The natural compound capsaicin has been shown to have anti-cancer effects, but its heat can also cause a burning sensation, stomach cramps, gut pain and nausea. In the new work, the researchers studied arvanil, a synthetic capsaicin analog without capsaicin's undesirable side effects.  When the researchers exposed two cisplatin-resistant lung cancer cell lines to a low concentration of arvanil, they saw no growth-inhibitory activity. However, when they treated the cells with varying concentrations of SN38 -- the active ingredient irinotecan -- they observed that the presence of arvanil greatly enhanced the ability of SN38 to slow cancer cell growth. Statistical analysis showed that the interaction between arvanil and SN38 was synergistic in nature.  "Because arvanil enhanced the anti-cancer activity of SN38 in human small cell lung cancer cells, arvanil-based combination therapies may be useful for patients with relapsed small cell lung cancer cells," said Friedman. "We hope that this work will pave the way for novel therapies for relapsed and cisplatin-resistant small cell lung cancer."     Five Therapeutic Properties of Medicinal Mushrooms GreenMedInfo, April 25, 2021   Mushrooms have recently gained popularity in culinary circles, but their far-reaching therapeutic properties should get your attention for a longer and healthier life. Although mushrooms have been part of the healer’s toolbox since ancient times, the medicinal power of mushrooms is gaining momentum in evidence-based journals. Medicinal mushrooms come in a wide variety and shapes such as white button, reishi, maitake, shiitake, oyster, cordyceps, cauliflower, tiger tail and lion’s mane, and most have health benefits that range from fighting cancer and boosting your immunity and memory to preventing diseases like diabetes and arthritis. 1. Anticancer Reishi (in Japanese) or lingzhi (in Chinese) mushrooms are well known in Asia for their anticancer properties. In a meta-analysis by scientists of 23 trials involving 4,246 cancer patients, reishi mushrooms enhanced longevity and quality of life in cancer patients.[i] Therapy with white button mushrooms impacted prostate-specific antigen (PSA) levels and inhibited prostate cancer by decreasing immunosuppressive factors.[ii] Polysaccharides from Cordyceps cicadae mushrooms inhibited the growth of cancer cells and induced cancer cell deaths showing its effectiveness as a low cost and safe treatment for cervical cancer.[iii] A peptide from the shiitake mushroom showed promising results in growth arrest, cell death and cleaning out damaged cells in a breast cancer in vitro study.[iv] In both in vitro and in vivo studies, results showed that mice with induced testicular cancer treated with the Cordyceps sinensis mushroom had significantly smaller and fewer tumors than the control group.[v] Cordyceps cicadae mushroom treatment prevented testicular damage and tumors caused by the chemotherapy drug cisplatin via inhibition of oxidative stress and inflammation in rats.[vi] In a lung cancer-induced study of mice, treatment with reishi mushrooms inhibited cell viability and mobility of lung cancer cells in vitro.[vii] In a cell study of reishi mushroom extract, the treatment offered high antitumor and liver protection with low toxicity on human liver cancer cells.[viii] 2. Immunomodulatory In a meta-analysis of 20 animal disease studies, grifola frondosa, or maitake mushroom, polysaccharide showed strong immune function by enhancing T cells, natural killer cells and macrophages in mice and increasing the secretion of two important immune factors, TNF-α and INF-γ.[ix] In a clinical study of 105 cancer patients undergoing chemotherapy or radiation treatments, a combination of reishi mushroom extract and geraniums improved immunity and fought the cancer and secondary infections that could have compromised treatment and health.[x] In a study of 18 patients diagnosed with low and intermediate myelodysplastic syndrome, which can lead to leukemia if not managed well, maitake mushroom extract treatment of three milligrams (mg) twice a day for 12 weeks increased immunity, positively affecting neutrophil, monocyte and free radical production.[xi] In a clinical study of asymptomatic children from 3 to 5 years old, treatment with beta glucans from reishi mushrooms showed increased immune system cells in the peripheral blood — signaling a strong defense against childhood infections.[xii] Reviewing in vivo and in vitro studies on mice and human cell lines using lion’s mane (Hericium erinaceus) and tiger tail (Trametes versicolor) mushrooms, treatments showed immunomodulatory, anticancer, anti-inflammatory and neuroregenerative effects.[xiii] 3. Antioxidant Polysaccharide beta glucan extracted from reishi mushroom was shown to be a powerful antioxidant in 37 high risk and 34 stable angina patients; those who were treated with 750 mg per day for three months had significantly decreased oxidative radicals and improved progression of atherosclerosis.[xiv] In a study of 42 healthy subjects, another intervention with beta glucan from reishi mushrooms of 225 mg per day for three months demonstrated its antioxidative effects — enhanced total antioxidant capacity and enzyme activities as well as reduced mild fatty liver condition to normal by suppressing oxidative stress were observed.[xv] 4. Anti-inflammatory  Crohn’s disease is a chronic inflammatory disease of the gastrointestinal tract. Treatment with a triterpene compound from reishi mushrooms showed that the inflammatory cytokines were significantly inhibited in a study of children with Crohn’s disease.[xvi] Sixty patients with moderate persistent asthma were studied and those who took the cordyceps sinensis mushroom capsule for two months had reduced airway inflammation caused by their chronic asthma.[xvii] Cordycepin from medicinal mushrooms showed strong effects on many anti-inflammatory diseases.[xviii] In a study of 32 patients with active rheumatoid arthritis, supplementation of medicinal mushroom and Chinese herbs — reishi (4 grams) and San Miao San (2.4 grams) daily — lowered arthritic pain for patients.[xix] The data in a mice study support a model where white button mushrooms regulate immunity in vitro and protect the colon from inflammation-induced injuries in vivo.[xx] The brain is susceptible to inflammation as well. In an Alzheimer’s disease model of rats, treatment with medicinal mushroom extracts delayed disease progression, improved learning and memory functions and stopped neural cell deaths and brain atrophy.[xxi] Chaga mushrooms administered to mice successfully protected against Alzheimer’s disease by modulating oxidative stress, Nrf2 signaling and mitochondrial cell deaths while improving memory and cognition.[xxii] Cordycepin from the Cordyceps sinensis mushroom alleviated Parkinson’s disease motor disorder symptoms by lowering oxidative stress and inflammation in vivo and in vitro.[xxiii] Lion’s mane mushrooms were supplemented for 12 weeks and were effective in preventing dementia and cognitive decline.[xxiv] Lion’s mane supplementation for four weeks in a study of 30 females also reduced depression and anxiety.[xxv] 5. Antidiabetic Dyslipidemia, high blood cholesterol and triglycerides is often a harbinger of future diabetes. In a rat model, white button mushrooms and a probiotic were found to lower dyslipidemia and decrease oxidative stress.[xxvi] In a study of 89 diabetic patients, oyster mushroom consumption significantly reduced blood glucose, blood pressure, triglycerides and cholesterol without ill effects on the liver or kidneys.[xxvii] Polyphenols from Phellinus igniarius, or willow bracket, mushroom extract were used in vitro and in vivo studies of induced Type 2 diabetes mice and showed improved glucose tolerance, reduced hyperglycemia and normalized insulin levels.[xxviii] Diabetic nephropathy, kidney disease caused by Type 2 diabetes, was studied in vitro with disease-induced rats and treatment with Cordyceps cicadae resulted in improved insulin resistance and glucose tolerance, suppressed inflammation and balanced gut microbiome thus stopping the diabetes-related progression of renal disease and tumors.[xxix] In an animal study, maitake mushroom prevented the progression of kidney fibrosis in diabetic nephropathy rats, significantly decreased fasting blood glucose levels, reduced inflammatory cytokines and lowered renal fibrosis indexes indicating its effectiveness in the treatment or prevention of nephropathy.[xxx] In their meta-analysis of 623 articles and 33 randomized controlled experiments using cauliflower mushroom extract (S. Crispa), researchers found statistically significant differences in diabetic symptoms including decreased serum insulin levels and wound rates and an increase in nutrient intake content.[xxxi] Mushrooms and Their Medicinal Powers Medicinal mushrooms are widely researched and used as treatment in the prevention and progression of many diseases from cancer and asthma to diabetes and dementia. Mushrooms protect you due to their anti-inflammatory, antitumor, antidiabetic, immune boosting and antioxidant activities. To learn more, see GreenMedInfo.com’s database on mushrooms.          

Hafner, Marco, Martin Stepanek, Jirka Taylor, Wendy M. Troxel, and Christian Van Stolk. Why sleep matters — the economic costs of insufficient sleep: A cross-country comparative analysis.: CA: RAND Corporation; 2016 [cited 2020 August 26] Available from: URL: https://www.rand.org/pubs/research_reports/RR1791.html#related. · https://www.tk.de/resource/blob/2033604/118707bfcdd95b0b1ccdaf06b30226ea/schlaf-gut-deutschland-data.pdf · Harbison ST, Serrano Negron YL, Hansen NF, Lobell AS. Selection for long and short sleep duration in Drosophila melanogaster reveals the complex genetic network underlying natural variation in sleep. PLoS Genet 2017; 13(12): e1007098. · Ruesten A von, Weikert C, Fietze I, Boeing H. Association of sleep duration with chronic diseases in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study. PLoS ONE 2012; 7(1): e30972. · Cappuccio FP, Cooper D, D'Elia L, Strazzullo P, Miller MA. Sleep duration predicts cardiovascular outcomes: a systematic review and meta-analysis of prospective studies. England; 2011 Jun. · Cappuccio FP, D'Elia L, Strazzullo P, Miller MA. Sleep duration and all-cause mortality: a systematic review and meta-analysis of prospective studies. Sleep 2010; 33(5): 585–92. · ADAC. Müdigkeit im Straßenverkehr (https://www.adac.de/-/media/pdf/motorwelt/muedigkeit_im_strassenverkehr_flyer_48789.pdf?la=de-de&hash=740ECDBA9CAB51D89AC47AB88EBFC6D4041843B5) · Wang G, Grone B, Colas D, Appelbaum L, Mourrain P. Synaptic plasticity in sleep: learning, homeostasis and disease. Trends Neurosci 2011; 34(9): 452–63.

Gary takes on the real issues that the mainstream media is afraid to tackle. Tune in to find out the latest about health news, healing, politics, and the economy. Study shows that mindfulness can help ease the pain of breast cancer survivors University of Ottawa (Canada), January 6, 2021 A study led by University of Ottawa researchers provides empirical evidence that mindfulness has a significant impact on the brain of women suffering from neuropathic pain related to breast cancer treatment. The researchers showed that mindfulness-based stress reduction (MBSR) helps modulate neuropathic pain. Their findings could make a difference in the lives of many women. In Canada, over a quarter of a million women are expected to be diagnosed with breast cancer - the most diagnosed cancer among women worldwide - in 2020. In addition to the psychological impacts of breast cancer, approximately 20 to 50 percent of survivors report experiencing chronic neuropathic pain following treatment. We talked to senior author Dr. Andra Smith, Full Professor at the uOttawa School of Psychology, to learn more about the most recent findings published in the journal Mindfulness. Why did you and your team decide to look at mindfulness to improve pain-related problems? "Neuropathic pain is a very common side effect of chemotherapy and other breast cancer treatments. Pain killers do not always work and quality of life, cognitive abilities, and overall well-being can be reduced due to this pain. Due to these negative effects and the complexity of treatment for this type of pain following breast cancer treatment, it is important to provide adjunct treatment and management options. We have heard a lot about mindfulness over the past few years, about how it helps people relax and feel better. If mindfulness, a non-pharmacological tool, can be used to help with neuropathic pain, women will feel better and might not experience such disruptive pain. Pain is a subjective experience and mindfulness is often dismissed as a "buzz word." But our research provides objective, empirical evidence of a significant impact of mindfulness on the brain of these women." How was the research conducted? "We investigated the impact of an 8-week mindfulness-based stress reduction (MBSR) program on emotional reactivity among a sample of breast cancer survivors with chronic neuropathic pain. We used state-of-the-art brain imaging at The Ottawa Hospital, on their 3T MRI scanner and collected data on white matter health, brain activity during emotional pain related word processing and during resting state. Women with neuropathic pain were imaged before and after an MBSR program, or treatment as usual. Pain, quality of life, and imaging were compared between the two groups and within the MBSR group pre- and post-MBSR." What did you find? "We observed major reductions in brain activity following mindfulness-based stress reduction in regions related to pain, emotional regulation, and cognitive processing. Both pain severity and pain interference, for the MBSR group, were significantly reduced after the 8-week training. Our results show a significant improvement in brain health as well as in pain perception. There are many anecdotal reports of how this or that made a person "feel better" but the really exciting results here are that we can see that there are actual changes in the brain and the way a person can alter their response to pain." Why is it important? "This research provides hope for a non-invasive method of easing the struggle of chronic neuropathic pain in women following breast cancer treatment. Pain is something that people fear, and many people run into significant secondary problems because of their pain medication use, including drug misuse and mental health issues. Mindfulness has a neurophysiological effect that can alter one's perception of pain. This research shows that there are adjunctive treatment options. If used properly, the information we have published can improve health outcomes for the people involved and could potentially also reduce health costs, as well as some of the related problems - particularly those related to mental health." Who worked on this research? "Dr. Patricia Poulin, at The Ottawa Hospital, was the clinical principal investigator with her research team of Heather Romanow, Yaad Shergill, Emily Tennant, and Eve-Ling Khoo. This included recruitment of the women and all clinical assessments. My lab performed the scanning component of the study, including my imaging team of Dr. Taylor Hatchard, Ola Mioduszewski and Dr. Lydia Fang. The data was collected over two years, from 2017 to 2019, funded by both Canadian Institutes of Health Research (CIHR) and Canadian Breast Cancer Foundation grants. We published three articles on our research in the last four months. The latest, "Reduced Emotional Reactivity in Breast Cancer Survivors with Chronic Neuropathic Pain Following Mindfulness-Based Stress Reduction (MBSR): an fMRI Pilot Investigation" was published in November 2020 in the journal Mindfulness." Moderate calcium intake, supplementation associated with reduced mortality risk during up to two decades of follow-up University of Aberdeen (UK), January 6 2021. A study and meta-analysis reported on December 31, 2020 in the European Journal of Epidemiology found a lower risk of premature mortality from any cause among men and women who consumed moderate amounts of calcium. Supplementing with calcium was associated with a lower risk of mortality from all causes among women. Tiberiu A. Pana and colleagues conducted a study that examined the effects of calcium among 17,968 participants in the European Prospective Investigation of Cancer, Norfolk (EPIC-Norfolk). The results were then included in a meta-analysis of 26 studies with a total of 1,828,149 subjects that evaluated the association between calcium intake and all-cause mortality, cardiovascular mortality, and incident cardiovascular disease, aortic stenosis, heart failure, myocardial infarction, peripheral vascular disease and stroke. When divided into fifths according to amount of their calcium intake, EPIC-Norfolk participants whose intake of calcium was between 771 mg and 926 mg per day had a 9% lower risk of dying from any cause and participants whose intake was 1074 mg to 1254 mg had a 15% lower risk in comparison with subjects whose intake was among the lowest fifth at less than 770 mg. Cardiovascular disease mortality was also reduced in these groups. A moderate intake of calcium was associated with a significantly lower risk of stroke, while the reduction in risk associated with an intake of more than 1255 mg per day failed to reach significance. The meta-analysis found a lower risk of all-cause mortality in association with higher calcium intake compared to lower intake. Calcium supplementation was associated with lower all-cause mortality among women, while no significant association was observed among men. “Moderate dietary calcium intake may protect against cardiovascular and all-cause mortality and incident stroke,” the authors concluded. Health benefits of replacing wheat flour with chickpea flour Kings College London and Quadram Institute, January 11, 2021 Researchers from the Quadram Institute and King's College London have shown that replacing wheat flour with a new ingredient derived from chickpeas improved the glycaemic response of people eating white bread. The ingredient uses specially developed milling and drying processes that preserves cellular structure, making its starch more resistant to digestion. Developing food products that contain more of this resistant starch would help to control blood glucose levels and reduce risk of type 2 diabetes. Starch from wheat is a major source of dietary carbohydrate, but in bread and many other processed foods it is quickly digested to glucose in the body, causing a large spike in blood glucose levels. There is a large body of evidence that links long-term consumption of foods that provoke high glycaemic responses to the development of Type II diabetes. With this condition on the rise, along with obesity and other metabolic disorders, providing foods and ingredients that help consumers better manage blood glucose could help combat these challenges to health. Many pulses, such as chickpeas, peas, beans and lentils naturally contain high amounts of resistant starch, which is digested slowly and avoids potentially damaging blood glucose spikes. But most of this beneficial resistance is lost, rendering the starch highly digestible, when these crops are milled to flour and processed into a food product. For this reason, the scientists invented an alternative milling process, which preserves the plant cell wall structures (dietary fiber) that surround the starch. This 'Type 1' resistant starch is the same as that found in wholefoods, but this new ingredient can be used in a form that potentially allows it to be incorporated into a wider range of foods. Funding from the Biotechnology and Biological Sciences Research Council (BBSRC), part of UKRI, was used to develop the commercial potential of this novel ingredient, referred to as PulseON, and expands the possibilities for including large amounts of resistant starch in processed foods to improve nutritional quality. And now, in a new study published in the journal Food Hydrocolloids, the research team shows for the first time that the resistant property of the starch is retained during bread making, and that people who ate bread rolls where some wheat flourwas replaced by PulseON had lower blood glucose responses. In a double blind randomized cross over study, the scientists replaced 0%, 30% or 60% of the wheat flour in a standard white wheat bread recipe with PulseON. Healthy human participants consumed each type of bread roll type for breakfast in random order on separate days, with no knowledge of which type of roll they were eating. Their glucose levels were recorded using continuous glucose monitors. Blood glucose responses to the PulseON enriched breads were on average 40% lower than after eating the control breads. All bread rolls contained similar amounts of starch and wheat protein (gluten) per serving, so the different blood glucose responses reflect the carbohydrate quality. These results raise the possibility of using such foods for improving the dietary management of diabetes, which needs to be evaluated in future studies. The digestion of starch in each bread type was also studied in a laboratory using biochemical and microscopy techniques. These experiments showed that after two hours of digestion, the wheat starch had been digested, but the type-1-resistant starch remained. This confirms that the lower glucose response to PulseON enriched breads was due to the resistant starch enclosed in the chickpea ingredient not being digested. "Incorporating our new type of flour into bread and other staple foods provides an opportunity to develop the next generation of low glycaemic food products to support public health measures to improve health through better diets" said Dr. Cathrina Edwards from the Quadram Institute. "Consumers replacing wheat bread with PulseON enriched bread would benefit not only from the type 1 resistant starch, but also from the higher fiber and protein content." For widespread acceptance, the qualities of the products such as their taste, texture and appearance need to match those that are so popular with consumers. Participants gave the PulseON enriched breads similar scores for texture and taste as the white bread. Quality tests indicated that any effects on bread quality (texture, appearance) were subtle and most noticeable when large amounts of PulseON were used. The sensory properties need to be confirmed with a broader consumer group in a non-clinical setting, but are very encouraging for efforts to produce healthier white bread without adverse effect on product quality. The technology is patent-protected and the group are looking at commercial exploitation. Previous research from the same group has shown that the same milling process may be applied to other beans, lentils and pulses, resulting in cellular powders high in resistant starch, but with different colors and flavors. The researchers are now exploring ingredient applications in a broader range of foodproducts, and planning further trials involving those with prediabetes and type 2 diabetes. Traditional Chinese water-only fasting associated with reduced thrombosis risk Soochow University School of Medicine (China), January 4, 2021 According to news reporting based on a preprint abstract, our journalists obtained the following quote sourced from medrxiv.org: “Beego is a traditional Chinese complete water-only fasting practice initially developed for spiritual purposes, later extending to physical fitness purposes. Beego notably includes a psychological induction component that includes meditation and abdominal breathing, light body exercise, and ends with a specific gradual refeeding program before returning to a normal diet. Beego has regained its popularity in recent decades in China as a strategy for helping people in subhealthy conditions or with metabolic syndrome, but we are unaware of any studies examining the biological effects of this practice. “To address this, we here performed a longitudinal study of beego comprising fasting (7 and 14 day cohorts) and a 7-day programmed refeeding phase. “In addition to detecting improvements in cardiovascular physiology and selective reduction of blood pressure in hypertensive subjects, we observed that beego decreased blood triacylglycerol (TG) selectively in TG-high subjects and increased cholesterol in all subjects during fasting; however, the cholesterol levels were normalized after completion of the refeeding program. Strikingly, beego reduced platelet formation, activation, aggregation, and degranulation, resulting in an alleviated thrombosis risk, yet maintained hemostasis by sustaining levels of coagulation factors and other hemostatic proteins. Mechanistically, we speculate that downregulation of G6B and MYL9 may influence the observed beego-mediated reduction in platelets. Fundamentally, our study supports that supervised beego reduces thrombosis risk without compromising hemostasis capacity. Moreover, our results support that beego under medical supervision can be implemented as noninvasive intervention for reducing thrombosis risk, and suggest several lines of intriguing inquiry for future studies about this fasting practice Assessing the antimicrobial activity of flaxseed NGH Institute of Dental Sciences & Research Centre (India), January 5, 2021 Researchers in India evaluated the antimicrobial activity of flaxseed against known periodontal pathogens. They reported their findings in an article published in the International Journal of Herbal Medicine. Research suggests that the use of antibiotics is beneficial in the management of periodontitis. However, antibiotic resistance has now become a major global issue, and it is believed to have stemmed from the misuse of antibiotics. Many researchers now see herbal interventions as therapeutic strategies that deserve more research and attention. Flaxseed, a popular superfood rich in omega-3 fatty acids, has demonstrated potent antimicrobial and anti-biofilm activities in several studies. To further explore its potential, the researchers conducted an in vitro study that aims to assess the antimicrobial activity of flaxseed against periodontal pathogens. They prepared an ethanolic extract from flaxseed powder and determined its minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitansand Tannerella forsythia. The researchers reported that the flaxseed extract exhibited bacteriostatic activities against all three pathogens. At 100 microliters (uL)/milliliter (mL), the extract exerted bactericidal effects against P. gingivalis. Based on these findings, the researchers concluded that flaxseed can be used as a natural adjunct to periodontal therapy because of its bactericidal effects against P. gingivalis. Vitamin B3 may benefit those with Parkinson's disease University of Leicester, January 11, 2021 Individuals with a specific type of Parkinson's disease (PD) could gain from increasing vitamin B3 (niacin) content in their diet, say British investigators. The findings point to niacin’s ability to increase levels of a compound responsible for energy generation and DNA repair. These factors — if left unattended — result in faulty mitochondria function that contributes to the progression of the neuro-degenerative disorder. "This study strengthens the therapeutic potential for Vitamin B3/niacin-based dietary interventions in the treatment of Parkinson's disease," said Dr Miguel Martins, lead study author and programme leader of the MRC Toxicology Unit at the University of Leicester. Niacin or Vitamin B3 is found in a number of foods, including liver, chicken, beef, fish, cereal, peanuts, and legumes. It can also be made from tryptophan, an essential amino acid found in most forms of protein. The team began by looking at studying fruit flies, specifically bred with a mutation that mimics PD. These flies specifically had a mutated form of the PINK1 gene that normally protects cells from stress-induced mitochondrial malfunction.   Flies were then fed food supplemented with niacin, which is made into the compound NAD inside the body. With this additional source of NAD, the researchers found flies had a lower number of faulty mitochondria than their mutant cohorts fed a regular diet. In addition, niacin also prevented the flies from losing existing neurons. “Mutations in PINK1 prevent cells from clearing out the defective powerhouses. When they accumulate, neurons can't get enough energy and die. The faulty mitochondria also release toxic molecules that damage their genes encoded by DNA,” said Dr Martins. “With all the mitochondrial damage going on, we wondered if in cases of Parkinson's the NAD compound ends up in short supply." The team also found that stopping DNA repair from depleting NAD kept mitochondria healthy and neurons alive, as well as enhance the flies' strength, mobility and lifespan. "The results suggest that in familial Parkinson's, available NAD is critical for keeping mitochondria in shape and the disease at bay,” said Dr Martins. While drug treatments exist that block NAD-consumption during the DNA repair process, Dr Martins thought increasing dietary niacin could provide certain benefits. "While neither of these would be cures, they would expand treatment options for Parkinson's patients with faulty mitochondria,” he added. excluded Study finds unfavorable intestinal microflora levels associated with the development of postmenopausal osteoporosis Fujin University (China), December 27, 2020 According to news reporting originating from Fujian, People’s Republic of China, research stated, “We aimed to investigate the intestinal microecology and fibroblast growth factor (FGF) expression in women with postmenopausal osteoporosis (PMO) and their clinical value in the diagnosis of PMO. A total of 214 postmenopausal women were analyzed retrospectively.” Our news editors obtained a quote from the research from the Department of Orthopedics, “The women were divided into the abnormal group (103 cases) and the normal group (111 cases) according to their bone mineral density (BMD). The levels of intestinal microflora and serum FGF-21, FGF-23, alpha-klotho, and beta-klotho were compared between the two groups, and the correlations of intestinal microflora, FGF-23, alpha-klotho, and beta-klotho with BMD were analyzed. The women in the abnormal group were further divided into the osteoporosis subgroup (59 cases) and the osteopenia subgroup (44 cases) for comparison. Receiver operating characteristic (ROC) curve was plotted to analyze the diagnostic value of intestinal microflora, FGF-23, alpha-klotho and beta-klotho for PMO. Compared with the normal group, the abnormal group had lower levels of bifidobacterium, lactobacillus, alpha-klotho, and beta-klotho and higher levels of enterococcus and FGF-23 (all P

Monologue Dr. Joel Wallach begins the show discussing the Covid 19 pandemic. Citing the numbers of cases and deaths in several different countries. Oultlining the fact that countries that don't eat wheat have less cases and less deaths. Asserting that gluten damages the intestines compromising the ability to absorb nutrients. Leading to pre-existing conditions putting people at risk problems if exposed to Covid 19. Pearls of Wisdom Doug Winfrey and Dr. Wallach discuss a news article regarding a European study of sugar intake. Finding those who drank two or more sugary sodas a week increased the risk of premature death by 17%. This from the European Prospective Investigation in Cancer and Nutrition. Including some 451,743 indivduals with some 41,693 dying from all causes during the 16 year period of the study. Callers Jackie has rheumatoid arthritis and high blood pressure. Cindy's husband has been diagnosed with a cyst on his pancreas. Agnes's son is recovering from Covid 19 and also has high blood pressure and atrial fibrillation. Roger has a follow up call regarding his rheumatoid arthritis. Call Dr. Wallach's live radio program weekdays from noon until 1pm pacific time at 831-685-1080 or toll free at 888-379-2552. Send an email to askdoc@deaddoctorsradio.com.

If exercise could be bottled, it would be THE wonder drug of all wonder drugs. There is not one condition, not one aspect of physical or mental health that exercise does not benefit.   On this episode we discuss why exercise is so beneficial to our health. We’ve evolved to exercise on a daily basis, however through time, with improvements in technology, we’ve become less active. Convenience comes at the expense of physical activity. The good news though, is that it doesn’t matter where you live, how old you are or how much you earn, regular exercise protects your health. We discuss how it protects the heart, how much we should do and how to incorporate this into a daily routine.   If you are in the difficult position of having a longterm condition, you may find it really hard to exercise. Please know that you are not alone. There are many resources out there that can help. One such resource is a UK based campaign called “We Are Undefeatable”. It’s been developed by 15 leading health and social care charities to support and encourage finding ways to be active that work with your condition and not against it. For more information please visit www.weareundefeatable.co.uk (http://www.weareundefeatable.co.uk/)   You can find more information about the Fresh Heart Project on our website www.freshheartproject.com (http://www.freshheartproject.com/) . If you have any suggestions or if you would like to share your own personal story please do get in touch @freshheartproject on Instagram, @freshheartproj on Twitter or via the website.   Remember great change comes with small steps that empowers you to live a life that you love.   References: 1)      Kohl, H. W. 3rd et al. The pandemic of physical inactivity: global action for public health. Lancet 380, 294–305 (2012). 2)    Zhao, G. et al. Leisure-time aerobic physical activity, muscle-strengthening activity and mortality risks among US adults: the NHANES linked mortality study. Br. J. Sports Med. 48, 244–249 (2014). 3)    Ekelund, U. et al. Physical activity and all-cause mortality across levels of overall and abdominal adiposity in European men and women: the European Prospective Investigation into Cancer and Nutrition Study (EPIC). Am. J. Clin. Nutr. 101, 613–621 (2015). 4)      Wen, C. P. et al. Minimum amount of physical activity for reduced mortality and extended life expectancy: a prospective cohort study. Lancet 378, 1244–1253 (2011).

Good lifestyle habits lead to better memory health Even small changes to improve your life, building good habits, can have effects that add up to a point of...  Better health, better cognitive function, and a better life. Your choices will bear fruit. Just like my mango tree. Who doesn’t love mangoes? The sweet smelling fruit is just so good. My family’s mango tree is an old tree, about 90 years old. The tree stopped bearing fruit a few years ago.  It’s been neglected. Fungal growth is spreading around. So we pruned. We planted. We attacked the fungal growth. We made changes here and there. Fortunately, it wasn’t too late to do something about it. Then things started to get better. No, much better! The tree started producing so many fruits that I’ve more mangoes than I‘ve chutney jars, Thai salads and gelato boxes. Yum! Your cognitive fitness is much like the mango tree.- But don’t leave it before it’s too late To be at your peak, to help prevent memory loss starts with the right nurturing, personalised to your situation The small changes in your lifestyle really do matter. Our daily habits add up to a bumper crop of memory health later in life. Habits are powerful. You probably don’t even realise you were doing them. That’s because they’ve been ingrained in your life, in your routine. Harness that power. Imagine being armed with habits that reduce your risks for memory loss. You become more confident. You go into battle ready armed to live life fiercely- on your own terms. Raar! What an image, right? But how do you go about creating and living with those good, daily habits? It’s hard to consistently make good choices that stick. There’s a way though. A way to learn how to successfully build new habits. Six principles that will lead to new, powerful habits. As long as you’re resolute. As long as you’re willing to keep at it. As long as you’re willing to keep grinding. You have your goal, your vision. And I know you can reach it. It is never too late to start. Do you really want to deprive your community of ALL that you can be? In today’s show, you will learn the 6 facets of how to build successful habits. Find out also what is the most often neglected element key to habit formation. Episode Highlights It’s Never Too Late For Change Setting The Right Goals For Developing Behaviour Repetition Leads To Successful Habit Formation 6 Principles For New Habit Success Quick Exercise For Finding Purpose The Biggest Takeaway about Key Lifestyle Factors For Better Health DOWNLOAD THE PDF TRANSCRIPTION   About Our Host David Norris is an occupational therapist who has been in this practice for 20 years. He has dealt with a lot of clients who seek help with their memory loss problems. David began asking himself about how these people can get ahead of these problems. It is then that he started teaching his clients how to improve their brain health to prevent memory loss. David Norris is also the director and founder of Occupational Therapy Brisbane.   Building New Habits It’s Never Too Late For Change My family's 90+ year old mango tree was able to bore fruits after years of not doing so. The tree had been neglected and was experiencing some fungal growth. Support and some tending helped it to thrive again. There is still the opportunity for your body to be primed to achieve as much as possible. Poor conditions increase the likelihood of memory loss happening again. It is never too late to start correcting your illness. Changing our diet can have a dramatic impact on your gut microbiome resulting in improved health and being.  Short exercises will release endorphins and give you improved endurance and focus. Meditation can easily be used to tackle stress. Setting The Right Goals For Developing Behaviour Goals are amazing. But set it too high and you set yourself up for failure. When you fall short of your goals, it’s easy to turn back to what you were doing before and give up. Not having goals though is like going on bushwalker track under dark conditions without a torch. The key is to narrow your vision and take each step at a time.  The step-by-step, methodological activity will help embed that new behaviour. Repetition Leads To Successful Habit Formation Old habits can sneak in and make you undermine your commitment to developing good behaviour like eating healthy. You feel guilt and shame. It erodes your sense of purpose, self, and strength to keep going. You want good behaviour to transform into good habits.  Committing to repetitive action will set you up for success. Habits can deal with anything. You do them even unconsciously. 6 Principles For New Habit Success Setting up supportive environments allows you to build things that trigger the new behaviour. Leverage context by keeping things simple. Do not overcomplicate things.  Eliminate friction or resistance by removing other choices or tasks. Put in place reward systems to support behaviour. Practice and repetition makes a habit stick. Having a sense of meaning to why you’re doing something is a powerful motivator. Quick Exercise For Finding Purpose Before starting, it’s important to be non-judgmental about yourself and be open. Think about what your family member will say about you at your funeral. Think about what your co-worker or community member will share about your impact in their lives. Think about what a stranger who has heard about you would say about you. This exercise will help you figure out what is the most important thing for you. What are the changes that need to be made for you to become that person they all talked about? You can still grow into the person you want to be at the end of your life.   Previously Recommended Resources Articles   The Science of Habit, October 2015. David Neal, Ph.D. Jelena Vujcic, MPH Orlando Hernandez, Ph.D. Wendy Wood, Ph.D. http://www.washplus.org/sites/default/files/resource_files/habits-neal2015.pdf  Exercise dose and quality of life: Results of a randomized controlled trial., Arch Intern Med. 169(3): 269–278. Corby K. Martin, Timothy S. Church, Angela M. Thompson, Conrad P. Earnest, Steven N. Blair (2009)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745102/ Effects of interval training on quality of life and cardiometabolic risk markers in older adults: a randomized controlled trial. Clin Interv Aging. 2019;14:1589–1599. Published 2019 Sep 4. doi:10.2147/CIA.S213133 Ballin M, Lundberg E, Sörlén N, Nordström P, Hult A, Nordström A. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732517/  Regular exercise and the trajectory of health-related quality of life among Taiwanese adults: a cohort study analysis 2006-2014. BMC Public Health. 2019;19(1):1352. Published 2019 Oct 23. doi:10.1186/s12889-019-7662-8 Chang HC, Liang J, Hsu HC, Lin SK, Chang TH, Liu SH. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6806516/ Long-Term Impact of Caregiving and Metabolic Syndrome with Perceived Decline in Cognitive Function 8 Years Later: A Pilot Study Suggesting Important Avenues for Future Research. Open J Med Psychol. 2013;2(1):23–28. doi:10.4236/ojmp.2013.21005 Brummett BH, Austin SB, Welsh-Bohmer KA, Williams RB, Siegler IC. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952276/#!po=65.0000  Gonzalez, C. (2006). The European Prospective Investigation into Cancer and Nutrition (EPIC). Public Health Nutrition, 9(1a), 124-126. doi:10.1079/PHN2005934 https://www.cambridge.org/core/journals/public-health-nutrition/article/european-prospective-investigation-into-cancer-and-nutrition-epic/F506B4D995930AD84F74289B5F16D132#  The Microbiome and Mental Health: Looking Back, Moving Forward with Lessons from Allergic Diseases. Clin Psychopharmacol Neurosci. 2016;14(2):131–147. doi:10.9758/cpn.2016.14.2.131 Logan AC, Jacka FN, Craig JM, Prescott SL. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857870/   Books Atomic Habits: The life-changing million copy bestseller by James Clear  Want to get 1% better everyday? Then this book may be just the next step for you. "A supremely practical and useful book, James Clear distils the most fundamental information about habit formation, so you can accomplish more by focusing on less." -Mark Manson   https://amzn.to/2twTRnB    Podcast Episodes Podcast Ep 005: Food, Mood, Microbiome and Your Memory with Dr Amy Loughman Podcast Ep 008: How Your Gut Health Affects Your Brain and Memory Health with Scott C Anderson   The Biggest Takeaway about Key Lifestyle Factors For Better Health Memory Health and making changes to help your body to achieve as much as it can is still possible. Remember the fruitless mango tree that bore again even when it was over 90+ years old. Quotable “Success takes time. Building these habits into your life takes time. These habits that make you into the gorgeous human being that you will be and are, will take time” - David Norris   What was your BIGGEST takeaway from this episode?      All the best  David  P.S. Did you get the free guide?  If not, here’s the link.    Disclaimer: Always seek the advice of your doctor or other qualified healthcare provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have heard on the podcast or on my website.

Ist es gesünder, sich vegetarisch zu ernähren? Alpha Progression App: alphaprogression.com/app Alpha Progression Gruppe: facebook.com/groups/alphaprogression Benjamins Insta-Profil: instagram.com/benjamin.alphaprogression Studien Chang-Claude und Frentzel-Beyme (1993): Dietary and lifestyle determinants of mortality among German vegetarians. ncbi.nlm.nih.gov/pubmed/8505178 Key et al. (2003): Mortality in British vegetarians: review and preliminary results from EPIC-Oxford. ncbi.nlm.nih.gov/pubmed/12936946 Key et al. (2009): Mortality in British vegetarians: results from the European Prospective Investigation into Cancer and Nutrition (EPIC-Oxford). ncbi.nlm.nih.gov/pubmed/19297458 Orlich und Fraser (2014): Vegetarian diets in the Adventist Health Study 2: a review of initial published findings. ncbi.nlm.nih.gov/pubmed/24898223 Le und Sabaté (2014): Beyond meatless, the health effects of vegan diets: findings from the Adventist cohorts. ncbi.nlm.nih.gov/pubmed/24871675 Orlich et al. (2013): Vegetarian dietary patterns and mortality in Adventist Health Study 2. ncbi.nlm.nih.gov/pubmed/23836264

Ist es gesünder, sich vegetarisch zu ernähren?Mehr zu Alpha Progression:https://alphaprogression.comhttps://facebook.com/groups/alphaprogressionhttps://instagram.com/alphaprogressionQuellen:Chang-Claude und Frentzel-Beyme (1993): Dietary and lifestyle determinants of mortality among German vegetarians. https://ncbi.nlm.nih.gov/pubmed/8505178Key et al. (2003): Mortality in British vegetarians: review and preliminary results from EPIC-Oxford. https://ncbi.nlm.nih.gov/pubmed/12936946Key et al. (2009): Mortality in British vegetarians: results from the European Prospective Investigation into Cancer and Nutrition (EPIC-Oxford). https://ncbi.nlm.nih.gov/pubmed/19297458Orlich und Fraser (2014): Vegetarian diets in the Adventist Health Study 2: a review of initial published findings. https://ncbi.nlm.nih.gov/pubmed/24898223Le und Sabaté (2014): Beyond meatless, the health effects of vegan diets: findings from the Adventist cohorts. https://ncbi.nlm.nih.gov/pubmed/24871675Orlich et al. (2013): Vegetarian dietary patterns and mortality in Adventist Health Study 2. https://ncbi.nlm.nih.gov/pubmed/23836264

In unserer aktuellen Podcastfolge geht es um das Thema Koffein. Ist es wirklich so ungesund und macht es uns kaputt oder ist es doch ungefährlich? Dieser Frage und dem Nutzen von Koffein gehen wir auf den Grund. Quellen: Bhaktha, G., Nayak, B. S., Mayya, S. & Shantaram, M., 2015. Relationship of Caffeine with Adiponectin and Blood Sugar Levels in Subjects with and without Diabetes. Journal of Clinical and Diagnostic Research, January, 9(1), pp. BC01-BC03. Daly, J. W., Holmen, J. & Fredholm, B. B., 1998. Is caffeine addictive? The most widely used psychoactive substance in the world affects same parts of the brain as cocaine.. Lakartidningen, 16 December, 95(51-52), pp. 5878-83. Ding, M. et al., 2014. Caffeinated and Decaffeinated Coffee Consumption and Risk of Type 2 Diabetes: A Systematic Review and a Dose-Response Meta-analysis. Diabetes Care, February, 37(2), pp. 569-586. Floegel, A. et al., 2012. Coffee consumption and risk of chronic disease in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Germany study.. American Journal of Clinical Nutrition, April, 95(4), pp. 901-8. Hogervorst, E. et al., 2008. Caffeine improves physical and cognitive performance during exhaustive exercise.. Medicine and Science in Sports and Exercise, October, 40(10), pp. 1841-51. Imatoh, T. et al., 2011. Coffee consumption but not green tea consumption is associated with adiponectin levels in Japanese males. European Journal of Nutrition, June, 50(4), pp. 279-84. Kempf, K. et al., 2010. Effects of coffee consumption on subclinical inflammation and other risk factors for type 2 diabetes: a clinical trial.. American Journal of Clinical Nutrition, April, 91(4), pp. 950-7. Li, S., Shin, H. J., Ding, E. L. & van Dam, R. M., 2009. Adiponectin Levels and Risk of Type 2 Diabetes - A Systematic Review and Meta-analysis. JAMA, 8 July, 302(2), pp. 179-188. Nurminen, M. L., Nittynen, L., Korpela, R. & Vapaatalo, H., 1999. Coffee, caffeine and blood pressure: a critical review.. European Journal of Clinical Nutrition, November, 53(11), pp. 831-9. Satel, S., 2006. Is caffeine addictive? - a review of the literature.. American Journal of Drug and Alcohol Abuse, 32(4), pp. 493-502.

Dr Tom Hubbard is a plant-based GP on a mission, not to change the world, but to do what is right. It is impossible for him to ignore the evidence and unread what he has read, when it comes to the health benefits of eating a plant-based diet. Claire and Andrew Davies met Tom on the Plantpower Ireland retreat, held by Rich Roll and Julie Piatt in July 2017. Like them, he'd signed up to attend the 7 day retreat and it quickly became evident that he would be a fascinating podcast guest. Tom is humble, engaging and thoroughly committed to presenting his patients with all of the options for treatment, including the benefits of eating a plant-based diet. In fact, he quotes a study that says even adding just one extra serve of fruit or vegetables per day can reduce cancer risk. His approach is one that’s about planting seeds for change rather than preaching or telling his patients what he thinks they should do. One of the best things about being able to interview people for this podcast, is hearing about the trigger that precipitated change in their lives. For Tom it was health, not his own but that of his mother, that lead him to become aware of the benefits of eating more plants. Also included in this conversation are stories of real patients and the transformations that Tom has witnessed and which have provided him with immense satisfaction and joy. The simple fact is that most members of the medical community are unaware of the profound benefits that eating a plant-based diet can have in preventing and reversing diseases such as heart disease, diabetes and some cancers. Dr Tom Hubbard gives us hope that things are changing and that as consumers of the health care system, we will soon be given all the facts and options, not just the ones that may be denying us the best health we can achieve.   Resources mentioned in this podcast episode Dr Tom Hubbard on Facebook Rich Roll Julie Piatt The Happy Pear Book "The China Study" (by T. Colin Campbell) Forks over Knives Michael Greger EPIC study (European Prospective Investigation into Cancer and Nutrition)

Chocolate is an important dietary source of flavonoid antioxidants, which are hypothesised to have a beneficial effect on endothelial function and protect against cardiovascular disease (CVD). In this podcast Dr Alistair Lindsay talks to Dr Phyo K Myint about his team's research into this topic. In order to evaluate any association between habitual chocolate consumption and the risk of cardiovascular events, they analysed data from the European Prospective Investigation into Cancer-Norfolk (EPIC-Norfolk), and incorporated the results from this observational study into the evidence available to date.