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4 episodes with Linearity
2 episodes with Linearity
2 episodes with Linearity
2 episodes with Linearity
2 episodes with Linearity
2 episodes with Linearity
2 episodes with Linearity
2 episodes with Linearity
3 episodes with Linearity
As a listener of TOE you can get a special 20% off discount to The Economist and all it has to offer! Visit https://www.economist.com/toe In this captivating of Theories of Everything, Jacob Barandes and I delve into the intricate world of Indivisible Stochastic Processes and their profound impact on quantum mechanics. We explore how these non-Markovian systems introduce quantum phenomena like superposition and interference without the traditional wave function collapse. Join My New Substack (Personal Writings): https://curtjaimungal.substack.com Listen on Spotify: https://tinyurl.com/SpotifyTOE Timestamps: 00:00 – Introduction 01:29 – Philosophy of Physics 07:04 – Philosophical Physics 10:55 – Understanding Symmetry Breaking in Physics 15:03 – Historical Contributions of Philosophers to Quantum Theory 25:03 – Real-World Examples of Symmetry Breaking 32:03 – Philosophical Contributions and Funding in Physics 38:00 – The Wigner's Friend Thought Experiment 55:24 – Eternalism vs. Presentism: The Flow of Time 1:05:31 – Connection to Cosmology and FLRW Models 1:12:07 – Spontaneous vs. Explicit Symmetry Breaking 1:15:37 – Indivisible Stochastic Processes and Future Directions 01:40:06 - Markovianity in Quantum Mechanics 01:42:12 - Linearity and Unitarity in Quantum Evolution 01:43:23 - Unistochastic Processes and Quantum Channels 01:45:20 - Quantum Channels and Steinspring Dilation 01:46:18 - Hamiltonian Formulation Analogy 01:49:05 - Double-Slit Experiment with Indivisible Processes 01:52:08 - Measurement Devices and Emergibles 02:00:04 - Seminar Culture and Philosophy in Physics 02:02:38 - Coarse-Grained Double-Slit Example 02:05:03 - No Wave Function Collapse in Indivisible Processes 02:12:16 - Philosophical Insights and Importance in Physics 02:18:08 - Critique of David Griffiths' Quantum Mechanics Textbook 02:35:07 - Closing Remarks and Future Topics Links Mentioned (additional links in comments): - Jacob's website: https://www.jacobbarandes.com/ - Jacob's first appearance on TOE: https://www.youtube.com/watch?v=7oWip00iXbo&ab_channel=CurtJaimungal - Jacob's talk on “A New Formulation of Quantum Theory”: https://www.youtube.com/watch?v=sshJyD0aWXg - The Stochastic-Quantum Correspondence (Jacob's paper): https://arxiv.org/pdf/2302.10778 - McTaggart's paper on time: https://philpapers.org/archive/MCTTUO.pdf - Putnam's paper on time and geometry: https://www.jstor.org/stable/2024493?origin=JSTOR-pdf - Neil deGrasse Tyson on TOE: https://www.youtube.com/watch?v=HhWWlJFwTqs - Einstein-Podolsky-Rosen paper: https://cds.cern.ch/record/405662/files/PhysRev.47.777.pdf - Greta Hermann's paper on quantum mechanics in the philosophy of nature: https://cqi.inf.usi.ch/qic/grete_en.pdf - John Bell's paper on the Einstein Podolsky Rosen paradox: https://journals.aps.org/ppf/pdf/10.1103/PhysicsPhysiqueFizika.1.195 - Bell's theorem without inequalities (paper): https://arxiv.org/pdf/quant-ph/0409190 - Quantum mysteries revisited (paper): https://www.physics.smu.edu/scalise/P5382fa15/Mermin1990a.pdf - Quantum Theory by David Bohm (book): https://www.amazon.com/Quantum-Theory-Dover-Books-Physics/dp/0486659690 - Bohm's second paper on quantum theory: https://journals.aps.org/pr/abstract/10.1103/PhysRev.85.180 - Dirac's textbook on quantum mechanics: https://www.amazon.com/Principles-Quantum-Mechanics-International-Monographs/dp/0198520115 - Wigner's paper on the mind-body question: https://www.scribd.com/doc/240712078/Eugen-Wigner-Remarks-on-the-Mind-body-Question #science #physics #theoreticalphysics #quantumphysics Learn more about your ad choices. Visit megaphone.fm/adchoices
Estas son las aplicaciones que he borrado del ipad en diciembre 2024: **Redes sociales y mensajería**: Facebook, X, LinkedIn, Messenger y Telegram, **Multimedia y edición:** Dazn, Mitele, iMovie, Shazam, HashPhotos, Linearity curve, fontmania, Color, Freeform, Match Triple 3D, Flikr**Juegos**: Magic y RetroArch**Otras:** Feedly, Pocket, Milanote, Trello, OpenVPN, OpenBank, Soulver, SpeedTest, Remote, Traductor de Google, Linky, Buy me a pie, Opener, RVNC ViewerYa hablé de los usos actuales que le doy a mi ipad en este capítulo: 61 - ¿Para qué uso mi iPad? https://podcasters.spotify.com/pod/show/al-daily-podcast/episodes/61---Para-qu-uso-mi-iPad-e2l9scn/a-abcsvf2Dime qué te ha parecido este capitulo y deja un comentario en ivoox o Spotify.Si lo prefieres, envíame un correo electrónico a la dirección de gmail almadailypodcast. En redes soy @almajefi y me encuentras en X / Twitter, Bluesky, Threads, Instagram y Telegram.
Jordan Wood answers a series of question on duality and nonduality, contemplation, embodiment, and time, in his explanation of Maximus the Confessor. Become a Patron! If you enjoyed this podcast, please consider donating to support our work.
Andre is joined by Aaron from SuperPod Saga to celebrate the life and times of the Dreamcast classic, the GameArts masterpiece, their favorite RPG ever, Grandia 2. You're gonna have to do better than that to beat us! Fine Time on Twitter: @FineTimePodcast SuperPod Saga on Twitter: @SuperPodSaga Andre on Bluesky: @pizzadinosaur.fineti.me Check out all the shows on SuperPod Network at superpodnetwork.com! [00:00] Intro & SuperPod Network [07:53] Release, Reception and Legacy [22:23] Graphics and Presentation [40:43] Characters, Dialogue, and Voice Acting [58:21] Plot Oddities and Linearity [01:06:56] Battle System and Dungeons [01:25:13] Music [01:38:04] Random Bits, Criticisms, and Conclusions [01:50:00] See Ya!
Are you watching closely? On the twenty- fifth episode of ATFT, my friend and writer/ director Samy El- Kamel returns to begin a new segment- episode, Nolanception, where we discuss and analyze specific and niche topics within the work of Christopher Nolan! The focus of this first edition of Nolanception is on non- linearity, specifically the non- linear structures of Nolan's films. This episode is explicit and spoiler- filled. Nolanception is the third segment introduced on ATFT! Christopher Nolan is both mine and Samy's favorite director and we both love film analysis so we often have analytical conversations surrounding Nolan's work. Our episodes tend to be longer because of that! Since we love talking about all things Nolan, we wanted to use ATFT to allow us to analyze deeper topics within Nolan's complex films. As we throw out in this episode, we have several niche topics in the works after this! We have been really looking forward to starting this segment and we are excited to continue creating episodes under this segment! This is Samy's eighth appearance on ATFT! He is now, after my friend and photojournalist Cole Echevarria, the second most frequent guest on this show! I am always grateful when he comes on the show and then later helps spread the word about our episodes and this podcast in general. He is one of my favorite guests and one of my favorite people to discuss film with, especially since he is a fellow massive Nolan fan. Samy and I first became friends, approaching three years ago, by talking about Nolan! As always, Samy's analyses and contribution to this episode is brilliant. This episode was recorded on July 9, 2024. Samy has a production company, Barefoot Python Media, and will be releasing his next short film, Waveform, this Winter! See the teaser trailer for the short as well as a variety of his other videos, such as “The Fate of Physical Media in 2024”, “All 12 Christopher Nolan Movies, Ranked | Including Oppenheimer (2023)”, and, his last short, Speak of the Devil. If you are a Better Call Saul fan, you will probably enjoy going through his Youtube channel, @BarefootPythonMedia, on YouTube. Samy also is an excellent photographer and is selling his prints on Darkroom. Support art by purchasing his prints here!: https://samyelkamel.darkroom.com If you love Christopher Nolan's work and Nolan- related humor, this episode is for you. In this episode, Samy and I go through all of Nolan's films, from Following to Oppenheimer, and discuss the non- linear structures. Naturally, we do stray from the main focus of the episode a few times, but it's always related to Nolan's films. One instance is when we laugh, and applaud, the one poorly written line in a Nolan film. Samy and I also talk about the ways Nolan continues to make the impossible possible, bizarre Dunkirk criticism, and the serious dilemma Samy faces every morning. All this and more on the latest episode of All the Film Things! Background music created and used with permission by the Copyright Free Music - Background Music for Videos channel on YouTube.
Has the idea of the end of the world captured your imagination? Ted Toadvine's book The Memory of the World: Deep Time, Animality, and Eschatology contends that a preoccupation with the world's precarity relies on a flawed understanding of time that neglects the past and present with the goal of managing the future. Toadvine integrates insights from phenomenology, deconstruction, critical animal studies, and new materialism to argue for a new philosophy of time that takes seriously the entangled temporal events spanning cosmic, geological, evolutionary, and human durations. Here Toadvine is joined in conversation with David Morris and Benjamin Décarie-Daigneault.Ted Toadvine is Nancy Tuana Director of the Rock Ethics Institute and professor of philosophy at The Pennsylvania State University.David Morris is professor of philosophy at Concordia University in Montreal.Benjamin Décarie-Daigneault is a graduate student of philosophy at The Pennsylvania State University.REFERENCES:Maurice Merleau-Ponty (body of works including Phenomenology of Perception)Immanuel KantDipesh ChakrabartyMichel Serres / The IncandescentMartin HeideggerJacques DerridaJean-Luc NancyJerome MillerHenri BergsonEdmund HusserlJames PlayfairJames Hutton (Hutton's Unconformity)John Sallis / StoneAdam Frank, Marcelo Gleiser, and Evan Thompson / The Blind SpotJane BennettDonald S. Maier / What's So Good About Biodiversity?Ferdinand de SaussureÉmile P. Torres / Human ExtinctionRachel Carson / Silent SpringKyle Powys WhyteAlfred North Whitehead / The Concept of Nature The Memory of the World: Deep Time, Animality, and Eschatology is available from University of Minnesota Press.“The Memory of the World achieves two important things: it steers our understanding of Merleau-Ponty toward a temporal interpretation of his thought and, at the same time, it uses that reading to make a critical intervention amongst theories of environmental apocalypse. Ted Toadvine's concept of ‘biodiacritics' should lead to a reorientation of the ‘eschatological imagination,' producing effects in knowledge that are as insightful as they are impactful. This is a wonderful book that is a pleasure to think alongside.”—John Ó Maoilearca
Having been accosted by two voices decrying the fate of the envious on the second terrace of Purgatory proper, Dante and Virgil begin to walk toward a stairway to the third terrace. As they do, Virgil, silent for quite a while, refocuses and reinterprets most of what we've read in PURGATORIO, Cantos XIII and XIV. He offers circularity in place of the linear descent so described by Sapía and Guido del Duca.Join me, Mark Scarbrough, as we see Virgil come into his own in Purgatory.If you'd like to help underwrite the hosting, streaming, editing, and licensing fees associated with this podcast, please consider donating whatever you can by using this PayPal link right here.Here are the segments for this episode of WALKING WITH DANTE:[01:33] My English translation of the passage: PURGATORIO, Canto XIV, lines 142 - 151. If you'd like to read along or continue the conversation with me, please go to my website, markscarbrough.com.[03:28] The bit, the rein, and the lure: in the passage at hand and in medieval iconography.[07:55] The question of what and how Virgil knows and can know the mechanics of Purgatory.[14:00] Refocusing the cantos of the envious.[16:52] Circularity inscribed into linearity.[21:51] Pain, redemption, and interpretation.[26:49] Rereading the passage: PURGATORIO, Canto XIV, lines 142 - 151.
Wiebke began her professional journey studying business and sociology, which laid the groundwork for her career. She first joined the sourcing department at Zalando and later transitioned into broader roles in People & Culture. Her experience spans startups, agencies and corporates, showcasing her versatile skill set and strong interest in organizational development. Within just seven years, Wiebke became a VP at Linearity, a powerful graphic design software known for its remote-first approach.Shownotes03:20 - Introduction05:55 - Rebranding11:08 - Shaping Company Culture - Company Values, Culture, Implementation21:07 - Strategic Talent Acquisition - Sourcing, Targeted Strategy, Diversity25:44 - Adapting Work Environments - Remote Work, Hybrid, Office SetupLinksWiebke Schmidt - https://www.linkedin.com/in/wiebke-schmidt-9772b3130/Thomas Linkedin: https://www.linkedin.com/in/thomas-kohler-pplwise/Thomas e-mail: thomas@pplwise.compplwise: https://pplwise.com/
Welcome to "AI Lawyer Talking Tech," where we explore the ever-evolving landscape of artificial intelligence in the legal industry. In today's episode, we'll delve into the revolutionary impact of AI in the legal sector, from the challenge of measuring the effectiveness of generative AI (GenAI) - as emphasized by legal technology expert Ken Crutchfield - to the groundbreaking initiatives undertaken by top law firms such as Clifford Chance. We'll also discuss the legal implications of AI, such as data breaches and copyright infringement cases, while exploring the innovative ventures shaping the future of legal technology. Join us as we uncover the opportunities and challenges of AI in the legal field and examine the transformative potential of these technological advancements. How Will You Measure Your AI?29 Feb 2024Above The LawAAA® Launches AAAi Lab Podcast on AI's Impact in Law with CEO Bridget McCormack and Host Zach Abramowitz29 Feb 2024Morningstar.comTop Magic Circle Firm Takes A Chance On Artificial Intelligence29 Feb 2024Above The LawSay Hello to Amplify: Your New Legal Marketing Agency29 Feb 2024Morningstar.comLaw firm reports data breach affecting more than 325,000 people29 Feb 2024Record by Recorded FutureNews Outlets Sue OpenAI Over Alleged Copyright Infringement29 Feb 2024JDJournalLegal Tech Entrepreneur and Former Kirkland & Ellis Partner Unveil Groundbreaking AI Venture29 Feb 2024JDJournalCall for Contributions: Special Issue--"Rhizomatic Law: Understanding the Linearity and Pendulum of Legal Evolution" in Undecidabilities and Law - The Coimbra Journal for Legal Studies29 Feb 2024Law at the End of the DayAI-powered contract analysis29 Feb 2024Financial Thomson ReutersLaw Society Library Introduces AI Subject Guide29 Feb 2024CryptopolitanNew Hampshire Lawmakers Ponder Taking Action on AI29 Feb 2024Government Technology USBloomberg Law Highlights Career Development Resources for Law Students29 Feb 2024Morningstar.comNew Martindale-Avvo 'Connect Experience' Marketing Platform Unifies Key Services, Empowering Attorneys and Law Firms To Increase Visibility and Reach29 Feb 2024Morningstar.comTime Law: A New Paradigm for Small Law Firm Efficiency and Growth29 Feb 2024Florida Bar NewsMarqeta Announces New SMB Credit Card Customer AffiniPay, Delivering A Flexible and Customized Credit Offering29 Feb 2024Fintech Finance NewsPablo Arredondo on the One-Year Anniversary of CoCounsel29 Feb 20243 Geeks and a Law Blog4 universities shaping the future for LLM graduates29 Feb 2024StudyInternational.comROSS Cofounder Returns To Legal Tech with Startup Using AI To Surface Judges' Decision-Making Patterns29 Feb 2024LawSitesIs Generative AI Fair Use of Copyright Works? NYT v. OpenAI29 Feb 2024Kluwer Copyright BlogOpenAI Faces Legal Challenges Over Copyright Infringement Claims29 Feb 2024CryptopolitanOpenAI faces New York Times hacking allegations while exploring deals with Tumblr29 Feb 2024Tech Wire AsiaThe future-focused legal team: Part 328 Feb 2024Financial Thomson ReutersCourt personnel remain unsure about Gen AI usage, want accuracy assurances29 Feb 2024Thomson Reuters InstitutePEW: A New Age of Enlightenment? A New Threat to Humanity? Experts Imagine the Impact of Artificial Intelligence by 204029 Feb 2024Stephen's LighthouseLegalOn Introduces Generative AI Assistant for Contract Work29 Feb 2024Legal Tech BlogUnlocking the Code to a Successful Acquisition of AI Technology29 Feb 2024Thompson Coburn LLPNew Executive Order to Block Businesses From Transferring Data to China and Other Countries of Concern – 4 Steps to Comply29 Feb 2024Fisher & Phillips LLP
Some teams punch above their weight. You can see that many organizations are still suffering from too much bloat, and defocused work. This week's episode shares more insights from my recent conversations with over 100 tech leaders globally about leveraging the concept of non-linearity to create profitable eng teams.New offering: I've talked to 100+ tech leaders recently about their 2024 plans and got repeating requests to offer help with this. The way you kick off the year has the potential to set you up for remarkable success and propel you forward. To help you achieve just that, I'm creating a Launchpad Propellent package. For $366 (2024 is a leap year!), you'll get prep work to consider, a planning session with me to come up with personal and team goals for the next ~3 months, and weekly accountability support for the first month. That's easily 70% cheaper than I usually charge for similar stuff. Write to me to book!Grab a copy of my books, Capitalizing Your Technology and The Tech Executive Operating System.Subscribe to the best newsletter for tech executives.For any questions or comments, reach out to me directly: aviv@avivbenyosef.com
Welcome to Bench Boost by Inorganic Ventures, the ultimate podcast for analytical chemists! Join Mike, our host and Technical Director, as he chats with some of our experts about the seventh chapter of our ICP Operations Guide, Linearity and Detection Issues.If you would like to follow along with us you can view the ICP Operations Guide on our website.Join us next week as we tackle Chapter 8, Spectral Interference: Types, Avoidance, and Correction.For more on-demand learning, explore our new virtual ICP academy, IV Ignite, for video courses, downloadable resources, community forums, and so much more.
Welcome to Bench Boost by Inorganic Ventures, the ultimate podcast for analytical chemists! Join Mike, our host and Technical Director, as he chats with some of our experts about the sixth chapter of our ICP Operations Guide, Compatibility and Precision Issues.If you would like to follow along with us you can view the ICP Operations Guide on our website.Join us next week as we tackle Chapter 7, Linearity and Detection Issues.For more on-demand learning, explore our new virtual ICP academy, IV Ignite, for video courses, downloadable resources, community forums, and so much more.
Arguing that intelligence is great deal more than processing and computation. Also that viewing the world through the single lens of cause and effect is a form of insanity.
In this week's Better podcast episode, we're revisiting an enlightening conversation with Lara Adler about the insidious world of endocrine-disrupting chemicals (EDCs) and their role in driving obesity, often referred to as obesogens. These harmful toxins lurk in our everyday lives, from personal care products to plastics and phthalates.Following up on our recent episodes featuring Dr. Shanna Swan, renowned author of "Countdown," and Kashif Khan, as they joined us to delve into the intricate web of EDCs. This discussion takes a deep dive into the far-reaching consequences of modern conveniences, exposing the negligence of government regulatory bodies in safeguarding our health.Lara Adler is an Environmental Toxins Expert and educator and a Certified Holistic Health Coach. She trains practitioners to become experts in everyday toxic exposures so they can improve client outcomes, with the unaddressed link between chemicals and chronic health problems.We discuss the truth about toxins in our everyday lives, from personal care products to feminine hygiene to cookware. As well as diving into understanding regulatory standards, toxicology, phthalates and PFAS.Links mentioned:Endocrine-Disrupting Chemicals (EDCs) - https://www.endocrine.org/patient-engagement/endocrine-library/edcsTop 10 Toxins – Health Professional Checklist - https://www.laraadler.com/top10checklistHow To Talk Toxins In Your 5, 14, or 28-Day Detox or Cleanse Program - https://www.laraadler.com/detoxguide/Dark Water movie - https://www.imdb.com/title/tt9071322/The Devil We Know documentary - https://www.imdb.com/title/tt7689910/Connect with Laura on:Lara's Website - https://www.laraadler.comFacebook - https://www.facebook.com/LaraAdlerHHC/Twitter - https://twitter.com/laraadlerEpisode Overview:0:00:00 Introduction0:03:14 The Journey Into Environmental Toxins and Passion for Change0:09:44 Absence of Evidence is Not Evidence of Absence0:13:08 Regulation: FDA, EPA, and Cognitive Dissonance0:16:37 Splintered Approach to Regulating Chemicals0:20:14 Acute Reactions vs. Long-term Effects of Toxicants0:23:38 Cocktail Effect and Amplified Effects of Chemicals0:27:16 Toxicology: Everything is a Poison, It's the Dose that Matters0:30:38 Testing the Assumption of Linearity in Dose-Response Relationship0:30:50 Lack of communication between endocrinology and toxicology0:34:48 Endocrine-disrupting chemicals defy linear dose-response curve0:38:21 Non-monotonic dose response curve challenges toxicology assumptions0:42:11 Individual Differences in Mercury Exposure and Effects0:49:41 Unregulated Industry: Understanding the Impact of Toxicology0:52:07 Challenging research: Isolating the cause of health problems1:01:38 The Impact of Heat and Oil on Migration1:03:12 Plastic Concerns: Scrubbing, Dishwashing, and Chemical Migration1:13:42 Creating an ideal kitchen for healthier food choices1:21:19 The Issue with Ceramic Non-Stick Cookware1:32:00 The Benefits of Reusing Glass ContainersWe'd like to thank our sponsors:For a limited time, get $100 off CAROL Bike with promo code BETTER. That's right, save money and time with CAROL Bike. Don't wait, visit www.carolbike.com today.
Everyone talks about the growing pains of starting the growth journey, but not so much about being years into it and then coming back to your previous environment. Today we dive into the realities and complexities of healing, as well as the isolation that may come with being on a nontraditional path. I share my thoughts on shifting from a victim to an empowered mindset. We talk about non-linearity, isolation, self-pity, drama, triggers, and allll the thingsss.
This week, Anna Rose (https://twitter.com/annarrose) interviews Avery Ching (https://twitter.com/AveryChing), Co-Founder and Chief Technology Officer at Aptos Labs (https://twitter.com/aptoslabs). They cover Avery's working history, including his time working on Meta's Blockchain project, what this experience meant to him and how this led to the creation of Aptos. They discuss Aptos as it stands today, Avery's experience of building in the current market and the unique qualities of the Aptos project. Here are some additional links for this episode: HotStuff: BFT Consensus with Linearity and Responsiveness by Maofan Yin, Dahlia Malkhi, Michael K. Reiter, Guy Golan Gueta and Ittai Abraham (https://dl.acm.org/doi/pdf/10.1145/3293611.3331591) Narwhal and Tusk: A DAG-based Mempool and Efficient BFT Consensus by George Danezis, Eleftherios Kokoris Kogias, Alberto Sonnino, Alexander Spiegelman (https://aptoslabs.com/assets/pdf/2105.11827-2284bd4d247772686f8cce16ae293575526f0d27.pdf) Check out the ZK Jobs Board here: ZK Jobs (https://jobsboard.zeroknowledge.fm/). Anoma's (https://anoma.net/) first fractal instance Namada (https://namada.net/) is launching soon! Namada is a proof-of-stake L1 for interchain asset-agnostic privacy. Namada natively interoperates with fast-finality chains via IBC and with Ethereum via a trustless two-way bridge. Follow Namada on twitter @namada (https://twitter.com/namada) for more information and join the community on Discord discord.gg/namada (http://discord.gg/namada). If you like what we do: * Find all our links here! @ZeroKnowledge | Linktree (https://linktr.ee/zeroknowledge) * Subscribe to our podcast newsletter (https://zeroknowledge.substack.com) * Follow us on Twitter @zeroknowledgefm (https://twitter.com/zeroknowledgefm) * Join us on Telegram (https://zeroknowledge.fm/telegram) * Catch us on Youtube (https://zeroknowledge.fm/)
Welcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is: Can we trust wellbeing surveys? A pilot study of comparability, linearity, and neutrality, published by Conrad S on March 17, 2023 on The Effective Altruism Forum. Note: This post only contains Sections 1 and 2 of the report. For the full detail of our survey and pilot results, please see the full report on our website. Summary Subjective wellbeing (SWB) data, such as answers to life satisfaction questions, are important for decision-making by philanthropists and governments. Such data are currently used with two important assumptions: Reports are comparable between persons (e.g., my 6/10 means the same as your 6/10) Reports are linear in the underlying feelings (e.g., going from 4/10 to 5/10 represents the same size change as going from 8/10 to 9/10). Fortunately, these two assumptions are sufficient for analyses that only involve the quality of people's lives. However, if we want to perform analyses that involve trade-offs between improving quality and quantity of life, we also need knowledge of the neutral point, the point on a wellbeing scale that is equivalent to non-existence. Unfortunately, evidence on all three questions is critically scarce. We propose to collect additional surveys to fill this gap. Our aim with this report is two-fold. First, we give an outline of the questions we plan to field and the underlying reasoning that led to them. Second, we present results from an initial pilot study (n = 128): Unfortunately, this small sample size does not allow us to provide clear estimates of the comparability of wellbeing reports. However, across several question modalities, we do find tentative evidence in favour of approximate linearity. With respect to neutrality, we assess at what point on a 0-10 scale respondents say that they are 'neither satisfied nor dissatisfied' (mean response is 5.3/10). We also probe at what point on a life satisfaction scale respondents report to be indifferent between being alive and being dead (mean response is 1.3/10). Implications and limitations of these findings concerning neutrality are discussed in Section 6.2. In general, the findings from our pilot study should only be seen as being indicative of the general feasibility of this project. They do not provide definitive answers. In the hopes of fielding an improved version of our survey with a much larger sample and a pre-registered analysis plan, we welcome feedback and suggestions on our current survey design. Here are some key questions that we hope to receive feedback on: Are there missing questions that could be included in this survey (or an additional survey) that would inform important topics in SWB research? Are there any questions or proposed analyses you find redundant? Do you see any critical flaws in the analyses we propose? Are there additional analyses we should be considering? Would these data and analyses actually reassure you about the comparability, linearity, and neutrality of subjective wellbeing data? If not, what sorts of data and analyses would reassure you? What are some good places for us to look for funding for this research? Of course, any other feedback that goes beyond these questions is welcome, too. Feedback can be sent to casparkaiser@gmail.com or to samuel@happierlivesinstitute.org. The report proceeds as follows: In Section 1, we describe the challenges for the use of self-reported subjective wellbeing data, focusing on the issues of comparability, linearity, and neutrality. We highlight the implications of these three assumptions for decision-making about effective interventions. In Section 2, we describe the general methodology of the survey. For the following sections, see the full report on our website. In Section 3, we discuss responses to the core life satisfaction question. In Sections 4, 5, and 6, we describe how we will assess co...
In this episode of ScreenTone Club Elliot and Andy get into a pair of mysteries - what is sneaky housekeeper Shizuka Yamauchi up to, and how the hell does human trainwreck Megumi Noda manage to survive living alone?Series Discussed: Nodame Cantabile Vol. 1, Burn The House Down Vol. 1Assignments for next Episode: Slasher Maidens Vol. 1, Oshi no Ko Vol. 1If you enjoy this episode, please consider backing us on Patreon - from only US$3 a month you get bonus episodes and other perks as well, including the ability to vote on topics for us to cover!We also have a Discord! Join us!We are affiliates on BookWalker! Using this link will give us a small kickback, helping cover the cost of manga for the podcast!TIMECODES:0:00:45 - Valentines! 0:02:30 - Elliot's Pick: Nodame Cantabile0:09:30 - Character Opinions0:15:30 - Wavelengths and Vibes 0:19:30 - Protagonist Syndrome / Andy is not a Romantic0:22:30 - Sparse Art? 0:26:30 - A Threat and a Promise0:30:00 - Andy's Pick: Burn the House Down0:31:30 - What ARE Names?0:33:45 - Soap Opera Melodrama!0:38:00 - Instagram Life0:42:45 - Asynchronous Warfare0:46:00 - Artwork Tension0:51:30 - The Tyranny of Linearity 0:55:00 - Comparison to Giant Robo OVA (!) 0:56:00 - SPOILER WARNING FROM HERE1:07:30 - END OF SPOILERS1:09:15 - Our Picks for Next Episode! 0:10:15 - Closedown!
Are you tired of feeling surprised in life? Do you feel overwhelmed by life's unexpected twists and turns? Did you know that life is nonlinear? How do we face the endless series of uncertainties while being gracious to ourselves? This is a featured interview on the Mental Health Toolbox podcast with Patrick Martin, LCSW. In this episode, Benoit and Patrick explore the topic of dealing with uncertainty and unpredictability in life by sharing practical wisdom and actionable insights on how to improve your mental health and well-being. Benoit and Patrick dive deeply into the best intervention strategies for dealing with uncertainty, the true purpose of psychotherapy, the importance of accepting our limited understanding of the world, and how curiosity can lead to healing. They also discuss why the world is full of conflicts and how to understand them in a better way. This conversation is full of practical insights and immediately implementable golden nuggets that you can use to improve your life. Whether you are struggling with anxiety, depression, or just looking for ways to improve your overall well-being, this episode is a must-listen. Expect to learn about the best clinically proven intervention strategies for life transitions, why we must accept our limited understanding of the world, best illuminating analogies and impactful quotes, and much more. Let's get this started.
In this episode, Remy & Q dig into the crimes and astrology of the Golden State Killer, Joseph James DeAngelo.
Change, whether in personal self-improvement or social evolution, is not linear. There are quantum leaps and discontinuities. This can be deeply unsettling and render obsolete previous ways of doing business and operating in the world.
In this episode, I chat with Bruce Feiler, a 7x New York Times Best-Selling author, presenter of two prime-time series on PBS, and writer of the "This Life" column in the New York Times, about mastering life's transitions. According to Bruce, people have linear and nonlinear moments throughout their lives. For example, up until the age of 40, Bruce had a pretty linear life. It wasn't until his cancer diagnosis that his life became severely nonlinear. This major event caused Bruce to begin collecting stories of people's nonlinear life experiences from all over the world. Throughout these nonlinear events in life, Bruce discovered a skill we can use to overcome these events or "lifequakes" to avoid being overwhelmed by them. This skill is called mastering life's transitions. Many people suffer through life events thinking they need to endure the pain and then they can be happy. However, Bruce introduces the concept of enjoying life during transitions to help you grow and renew yourself instead of suffering. As a result, those life transitions reveal opportunities to transform the trajectory of our lives, leading us down new and exciting paths. Thank you, Bruce, for sharing your story with me and the audience. Create the life you've always wanted!
Many of us need to understand and know how everything is connected before we move forward into something new. But is there a cost to always maintaining the linear processes and habituation of the mind, even if we think that by doing so we've got more of the variables covered? In this episode, we're discussing breaking out of the box — releasing attachment to linearity. We'll talk about what to watch out for, and why this is so important for having our frequency resonance rise. The GFC (Group Frequency Calibration®) associated with this episode will help you to begin to release the distortion patterns that limit your ability to have a much higher perspective. Let's rise together! If you would like an opportunity to ask me questions in real time, join me when I go live on YouTube. Subscribe to the Spherical Luminosity YouTube channel and click the reminder bell to be notified when I am live: http://bit.ly/SL-YTSubscribe For the latest news about upcoming events and to be notified when sessions with me are released, subscribe to our newsletter: http://bit.ly/SphericalLuminositynewsletter
Transcript: https://wearenotsaved.com/2022/07/31/eschatologist-19-the-non-linearity-of-baggage-systems/ I use the baggage chaos I encountered on a trip to Ireland as an example of fragility.
On this episode of the podcast, I was joined by Shadeed Salem, the Founder and President of Synergy Bioscience. Shadeed and I discuss: -War Stories in method validation and NCR/OOS's -What is it that you're going to test and what are you testing for? -Differences between drug and device methods including Analytical, Physical, Mechanical and Visual methods -Method Development vs. Method Validation -How to treat compendia methods (USP, ISO, etc) -Specificity, Bias, Linearity, Gage R&R Shadeed Salem MSc MBA CQE CQMOE CQA CSSBB CPGP is an industry matter expert with proven expertise in the establishment and remediation of quality systems based on regulatory requirements such as the FDA 21CFR 210, 211, QSR 820, ISO 9001, ISO 13485, ISO 14971, ISO 14644, and IEC 60601 and guidelines such as ICH, WHO, and PIC/S for pharmaceutical and medical device industries. Thorough knowledge and high level of expertise in writing protocols and implementing numerous validation studies such as Analytical Method Development/Validation, equipment qualification (IQ/OQ/PQ), Cleaning Validation, Cleanroom Qualification, Water System Qualification, as well as manufacturing process validations. Exceptionally skilled in performing Corrective Action / Preventive Action (CAPA) and Root Cause Analysis, Out of Specifications (OOS) Investigations, quality system auditing and compliance gap assessment, as well as providing training based on cGMP requirements.
Today I serve my listeners a harder nut to crack. It is obvious to more and more citizens that the republic urgently needs to transform itself. This is also being addressed. But well intended is not yet well done. I experience that the linearity bias, which makes evolutionary sense, is likely to lead us straight into massive problems. The 10 minutes of listening time are well invested in being able to better recognise the effect. Show notes: https://en.ka-brandresearch.com/wir-verstaerken-marken/#accordion-braincandies --- Send in a voice message: https://anchor.fm/uwe-ohnemus/message
The Chorus proposes another way we often deny ourselves the perspective of new and infinite creation: through the idea of redundancy, a version of the aspects of linear time they are starting to describe through these episodes. As we awaken, they suggest, we may see evidence on the Five Senses of a belief or limitation we thought we had already moved through. Is it redundant? As we feel more things energetically, we may recognize a valid, alternative view. Katie connects this to the aspects of linearity to which we are starting to awaken, including the burgeoning aspects of telepathic communication...which goes way beyond straight lines.Episode transcript available on our site. ANNOUNCEMENT - Book 2 is now available!! The Book of Human Remembrance, The Chorus's discussion of time and memory, is now available in ebook, paperback, and audiobook. Get yours now before time runs out! (Lol, JK, who are we kidding time is infinite). We
Nick Hirst is Executive Strategy Director at adam&eveDDB in London. He's twenty years into his planning career. He's been at adam&eveDDB for eight years and spent some of them as Head of Planning. That's after being a Head of Planning at Dare and working at Lowe and Grey. In this episode of Sweathead, we discuss the messy reality of doing account planning. You can find Nick here: https://twitter.com/nickhirst ** Find out about our Strategy Accelerator at http://www.sweathead.com Follow the fun on Instagram: http://www.instagram.com/sweathead Subscribe to our newsletter: http://eepurl.com/dscjW5
In this episode we discuss "Teaching digital media in a systemic way, while accounting for non-linearity" by Teodor Mitew (@tedmitew)
Welcome to Ask Stago, The Podcast dedicated to provide expert answers to your expert questions in coagulation. In today's episode, our expert Pauline Vasselon, US & Projects Registration Coordinator within Stago Market Access team, will provide us the key steps to implement a new instrument in your laboratory. Literature sources: ISO 15189 Medical laboratories — Requirements for quality and competence ISO 22870:2010 Intelligent transport systems — Devices to aid reverse manoeuvres — Extended-range backing aid systems (ERBA) CLSI Measurement Procedure Comparison and Bias Estimation Using Patient Samples, 3rd Edition, CLSI document EP09c, Wayne PA, 2018. CLSI Evaluation of Precision of Quantitative Measurement Procedures, Approved guideline, 3rd Edition CLSI document EP05-A3, Wayne PA, 2014. CLSI Evaluation of Linearity of Quantitative Measurement Procedures, 2nd edition, CLSI document EP06, Wayne PA, 2020. CLSI Protocol for the Evaluation, Validation, and Implementation of Coagulometers, Approved Guideline, CLSI document H57-A, Wayne PA, 2008. Related podcasts: Uncertainty of measurement - Manage lot conversion - Manage your pre-analyticals - Control the reference ranges of your method - Manage HIL interferences - Understand the sensitivity and specificity - Calculate your MNPT - Content is scientific and technical in nature. It is intended as an educational tool for laboratory professionals and topics discussed are not intended as recommendations or as commentary on appropriate clinical practice.
Shambhavi talks about linear vs associative thinking, sensing time and good timing, and living without being distracted from the natural state. A podcast from Satsang with Shambhavi Live satsang is mostly free range Q&A. "Tastings" are special episodes of our Satsang with Shambhavi podcast where you'll get to listen as students ask all kinds of questions and Shambhavi responds. Welcome to the buffet version of satsang! Curious to find out more about spiritual life, Trika Shaivism, and Shambhavi? Want to know how you can attend live and livestreamed teachings or get started practicing? Visit jayakula.org for lots more media, instruction in mantra and meditation, and a full calendar of IRL teachings with Shambhavi. You can also find us on FB and instagram @jayakula. Ask to join the private Jaya Kula News FB group to get access to the zoom link for satsang. And if you'd like to support these teachings, please rate and review this podcast as it helps others find us. You can also make a donation at jayakula.org/giving Thanks for listening! And much love to you, wherever and however you are.
This podcast is from the book "Analytical Chemistry", written by G. D. Christian and others, Topics are: Good Laboratory Practice (GLP), Quality Assurance and Method Validation. Learning objectives are: Good Laboratory- What it is, how to apply it! How to validate a method, Selectivity, Linearity, Accuracy, Precision, Sensitivity, Range, LOD, LOQ, Ruggedness. Quality Assurance- Control Charts, Documenting, Proficiency Testing, Electronic Records, What is 21CFR, Part-11! Official organizations that provide GLP information
In this episode, we delve into the world of time travel and what it means to shift timelines. Through unlocking and mastering these powerful codes, you get to bend time to hyper-charge your growth journey. We also take you through a couple of powerful activations where we connect you with your own wizard frequency and shift you into a reality you have never experienced. You will also learn important keys to a higher-dimensional manifestation that 99% of people are unaware of. May you receive from your heart centre, residing fully in your sovereignty! Alex is a powerful intuitive ascension mentor! Find more information about Alex and his work: Website: https://www.alexmglobal.com/ Instagram: https://www.instagram.com/wizardfrequency/ This episode covers: What timelines are How time works in the quantum Accessing our most ascended timeline Manifesting significant financial abundance What is preventing you from living your best life now Shifting timelines by allowing yourself to dream How to close down lower timelines Using energetic ‘levers' to manifest in 3D reality Feeling instead of thinking manifestations into physicality Creating space by clearing misaligned relationships Time travel and how to reprogram the past Guided activations to shift you to a new reality now Extra resources & links: Cendrine's online course on intuition: Galactic Intuitive Fractal Shifts 2.0 is launching on 2/7/2021. Sign up before 2/7 & receive 50% off: https://cendrines.kartra.com/page/fractalshifts
“Hey Siri” “Ok Google” “Hey Alexa”If I told you 15 years ago that we would all be talking to our electronic devices, would you have believed me? Would you have thought I needed some therapy?Regardless of your answer, it’s clear that speech recognition has become normalized. We now talk to our devices in order to call a friend, to find directions to a local restaurant, and even, when we are really bored, to tell us a joke.On today’s episode, we talk with Igor Jablokov, a pioneer in voice recognition. Igor led the team at IBM that created the first ever speech enabled web browser and then went on to found the company Yap, which was sold to Amazon in 2011 and became the basis for Amazon Alexa.Now, Igor is the CEO of another startup: Pryon — which seeks to bring the power of voice recognition to the enterprise level. Instead of having to manually sort through emails, databases, and documents at work, Pryon enables you to simply ask your device for the relevant information, and then the machine does the discovery and surfacing for you.But Igor is more than a technologist — he’s also a self described artist and creative. And the episode is about much more than just speech recognition — it’s about the power of adaptation, non-linearity, and believing in your own distinctive journey as you pursue innovation.As Igor said “There’s not a recipe. You can try and hit some of the basics. But each one of us has this unique fingerprint and path. It’s just doing the hard work every day”You can follow the podcast and host Chuck Swoboda on Twitter for further exploration and discussion on innovation.The episode is also available wherever else you listen to podcasts. Enjoy!
In this episode, Bailey builds off previous episode themes as they have been salient for her in the last few weeks. For anyone struggling to advocate for themselves, wrestling with over-apologizing, feeling like a burden, or being defeated by results or outcomes that were not "perfect," this episode might be comforting or helpful for you! Thank you for listening! :)
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.11.01.363838v1?rss=1 Authors: Chen, G., Nash, T. A., Reding, K. M., Kohn, P. D., Wei, S.-M., Gregory, M. D., Eisenberg, D. P., Cox, R. W., Berman, K. F., Kippenhan, J. S. Abstract: The ubiquitous adoption of linearity for quantitative explanatory variables in statistical modeling is likely attributable to its advantages of straightforward interpretation and computational feasibility. The linearity assumption may be a reasonable approximation especially when the variable is confined within a narrow range, but it can be problematic when the variable's effect is non-monotonic or complex. Furthermore, visualization and model assessment of a linear fit are usually omitted because of challenges at the whole brain level in neuroimaging. By adopting a principle of learning from the data in the presence of uncertainty to resolve the problematic aspects of conventional polynomial fitting, we introduce a flexible and adaptive approach of multilevel smoothing splines (MSS) to capture any nonlinearity of a quantitative explanatory variable for population-level neuroimaging data analysis. With no prior knowledge regarding the underlying relationship other than a parsimonious assumption about the extent of smoothness (e.g., no sharp corners), we express the unknown relationship with a sufficient number of smoothing splines and use the data to adaptively determine the specifics of the nonlinearity. In addition to introducing the theoretical framework of MSS as an efficient approach with a counterbalance between flexibility and stability, we strive to (a) lay out the specific schemes for population-level nonlinear analyses that may involve task (e.g., contrasting conditions) and subject-grouping (e.g., patients vs controls) factors; (b) provide modeling accommodations to adaptively reveal, estimate and compare any nonlinear effects of an explanatory variable across the brain, or to more accurately account for the effects (including nonlinear effects) of a quantitative confound; (c) offer the associated program 3dMSS to the neuroimaging community for whole-brain voxel-wise analysis as part of the AFNI suite; and (d) demonstrate the modeling approach and visualization processes with a longitudinal dataset of structural MRI scans. Copy rights belong to original authors. Visit the link for more info
Coyote Park is a Two Spirit artist, oral historian, and educator. They are Yurok (with their ancestral homelands being near the Klamath river), German, and Korean. Coyote grew up in Honolulu, Hawai'i and moved to New York when they were 18. Currently, they have relocated to Los Angeles where they are doing online lectures, finishing up schooling, and multi-media work. They cofounded ENBY Spoken Histories with Angel Labarte. ENBY Spoken Histories is a storytelling archive with the trans community, as it centers nonbinary, 2spirit, gnc, intersex, and genderqueer voices. The archive is preserved within the Library of Congress and ENBY Spoken Histories has a partnership with Storycorps. In the past, they have had multiple recording sessions in New York, Chicago, Los Angeles, and Hawai'i. There were set recording dates that had been pushed back due to Covid-19. However, on a digital platform ENBY Spoken histories has been hosting zoom parties with performances, book club meetings, and has done one healing circle run by QTPOC facilitators. Coyote's personal practice is documentary photography where they photograph the intimate moments within their daily life and trans family. They have also been curating a QTPOC dream zine, working on other written projects with artists in their community spaces, and have been utilizing social media as a tool for connection for Trans youth and emotional resonance for other trans folks. Coyote is passionate about building a framework of understanding of gender outside of the colonial gender systems and uses their work as an outlet to vocalize those narratives. Instagram: @nativeboytoy QUEER THE WELLNESS INDUSTRIAL COMPLEX LECTURE: GET TICKETS here. LITQB Podcast: This is a podcast about the barriers to embodiment and how our collective body stories can bring us back to ourselves. This is a podcast for people who identify as queer or for people who might think of their relationship between their body and confining social narratives as queer. This can feel like an isolating experience. Our wounded bodies need spaces to talk about struggles with nourishment/disordered eating, body image issues, dysphoria, racism, heterosexism, transphobia, xenophobia, substance use/abuse, chronic pain/disability, body changes in parenthood, intergenerational trauma, the medical/wellness/therapy industrial complex and its lack of inclusion of queer bodies and much more. Hopefully this podcast can illustrate the connections, and resonant pain points, that we have with one another. Livinginthisqueerbody.com @livinginthisqueerbody The Host: Asher Pandjiris is a Psychotherapist/ Podcaster/ Group Facilitator SUPPORT https://www.patreon.com/livinginthisqueerbody Sound Editing: Barry Orvin www.talkbox.studio Music: Ethan Philbrick and Helen Messineo-Pandjiris --- Send in a voice message: https://anchor.fm/asher-pandjiris/message
We talk and talk about our deepest shadows coming up to face and resolve right now; there's a LOT of that going on! How about looking at how much of it is because of how we measure our judgments based on linearity? What if we didn't? What does THAT mean? EVERYTHING... come and join us as we set the creation to have this all come together in a much easier - and expansive - way to see things...
What happens when you hit the ball really, really hard?
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.05.18.102558v1?rss=1 Authors: Hansen, C. B., Rogers, B. P., Schilling, K. G., Nath, V., Blaber, J. A., Irfanoglu, O., Barnett, A., Pierpaoli, C., Anderson, A. W., Landman, B. A. Abstract: Background: Achieving inter-site / inter-scanner reproducibility of diffusion weighted magnetic resonance imaging (DW-MRI) metrics has been challenging given differences in acquisition protocols, analysis models, and hardware factors. Purpose: Gradient fields impart scanner-dependent spatial variations in the applied diffusion weighting that can be corrected if the gradient non-linearities are known. However, retrieving manufacturer non-linearity specifications is not well supported and may introduce errors in interpretation of units or coordinate systems. We propose an empirical approach to mapping the gradient nonlinearities with sequences that are supported across the major scanner vendors. Study Type: Prospective observational study Subjects: Two diffusion phantoms (High Precision Devices diffusion phantom and a custom isotropic phantom), five human control volunteers. Field Strength/Sequence: 3T (three scanners). Stejskal-Tanner spin echo sequence with b-values of 1000, 2000 s/mm2 with 12 and 32 diffusion gradient directions per shell. Assessment: We compare the proposed correction with the prior approach using manufacturer specifications against typical diffusion pre-processing pipelines (i.e., ignoring spatial gradient non-linearities). In phantom data, we evaluate metrics against the ground truth. In human and phantom data, we evaluate reproducibility across scans, sessions, and hardware. Statistical Tests: Wilcoxon rank-sum test between uncorrected and corrected data. Results: In phantom data, our correction method reduces variation in metrics across sessions over uncorrected data (p
On this episode, I'm joined by my great friend and 4x International World Jiujitsu Champion, Margot Ciccarelli, more colloquially known as Mars. Beyond her achievements in the game, her way of thinking, living, and breathing the art have blended into a distinct approach that I hope you have a good time listening to. In this conversation, we cover the artist and the athlete, dance and the martial arts, linear and non-linear approaches to development, the abstract and the pragmatic, challenges and adaptations, physical languages, and a whole lot more in-between. You can learn more about Mars, her work, perspective, and coaching via her Instagram @thenomadicmars. Without further to say, please enjoy this conversation with the Nomadic herself, Margot Ciccarelli.
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.04.30.070623v1?rss=1 Authors: Bach, M., Atala-Gerard, L. Abstract: The Rotating Snakes illusion is a motion illusion based on repeating, asymmetric luminance patterns. Recently, we found certain grey-value conditions where a weak, illusory motion occurs in the opposite direction. There exist four models for explaining the illusion, one of which (Backus and Oruc 2005) also explains the unexpected perceived opposite direction. We here present a simple new model, without free parameters, based on an array of standard correlation-type motion detectors with a subsequent non-linearity (e.g., saturation) before summing the detector outputs. The model predicts (1) the pattern-appearance motion illusion for steady fixation, (2) an illusion under the real-world situation of saccades across the pattern occurring (pattern shift), (3) a relative maximum of illusory motion for the same grey values where it is found psychophysically, and (4) the inverse illusion for certain luminance values. We submit that its sparseness of assumptions justifies adding a fifth model to explain this illusion. Copy rights belong to original authors. Visit the link for more info
Let's dive deep into biochemistry! Chris and I discuss our beloved biological marcromolecules, and how they are all synthesised in a linear fashion, as a chain of monomers. I was wondering why this is, since especially proteins function through their 3D structure and the linear nature of the chain can be a drawback. For example, many diseases are related to misfolding of proteins, like Alzheimer's disease. We explore some ideas on pathway evolution and kinetic reaction control. In the end, Chris convinces me with an argument on information processing. As always: informal, unscripted, and highly subjective. Read more on fey-sci.com --- Send in a voice message: https://anchor.fm/fey-sci/message
In the preceding verses, Paul has focused the reader's attention on some crucial distinctions: law is different from grace, faith is different from works, and the Mosaic Covenant is different from the Abrahamic Covenant. In our text today Paul says being under the law is like being locked up in prison and having a correctional officer running your daily life. The sermon also focuses on what some have called "The Law of Linearity" which is the belief that if you follow the rules you get the result you desire; however, should getting the right results be our main motivation for doing the right thing or is there some better motivator?
In the preceding verses, Paul has focused the reader's attention on some crucial distinctions: law is different from grace, faith is different from works, and the Mosaic Covenant is different from the Abrahamic Covenant. In our text today Paul says being under the law is like being locked up in prison and having a correctional officer running your daily life. The sermon also focuses on what some have called "The Law of Linearity" which is the belief that if you follow the rules you get the result you desire; however, should getting the right results be our main motivation for doing the right thing or is there some better motivator?
In the preceding verses, Paul has focused the reader’s attention on some crucial distinctions: law is different from grace, faith is different from works, and the Mosaic Covenant is different from the Abrahamic Covenant. In our text today Paul says being under the law is like being locked up in prison and having a correctional officer running your daily life. The sermon also focuses on what some have called "The Law of Linearity" which is the belief that if you follow the rules you get the result you desire; however, should getting the right results be our main motivation for doing the right thing or is there some better motivator?
Non-linearity has literally has won and lost the Tour de France. Josh breaks down this important concept -- one he admits to sometimes having a tough time wrapping his brain around. The metaphor? Extreme betting during what would turn out to be a very expensive round of golf. From there we apply non-linearity to cycling and aerodynamics. Let's just say that after this episode, you will give serious consideration to shaving your head.
As we look at the span of our life and consider our maturity, we will often defaut to timeframes; for instance, references such as "when I was three..." or "my college years" create markers on a seemingly straight line of the time-travel we've embarked upon since birth. Yet we mature in spurts as well as at different rates from one another... and some family membersdon't seem to mature at all (mischevious joke). Join us as we discuss the organic nature of our maturity.
The perception of linearity keeps our world tidy and manageable.Yet it is merely a perception; in fact, it verges onillusion. An illusion is a distorted idea or mental concept of reality. In that we are constantly creating and shaping our ever changing world,it'suseful to leverage the idea of limitless potential. Join us as we discuss the limitations of perceived linearity.
Join the #BookSquad in the dusty, violent old west as we take on season 2 of HBO's 'Westworld' and spoil literally everything. Find out what "world" squad members want to go to, how we think season 2 compares to season 1, who are favorite characters are, and what worked and didn't work this go-round. Also, what's a robutt? We read some great listener feedback about 'Solo' and 'Hereditary' (and therefore get spooked about 'Hereditary' all over again!). Plus, find out what's on the #BookSquadBlog and what's coming up on the next fullpisode! Read along with us for 'Super Extra Grande' by Yoss, and be sure to catch 'Sorry to Bother You' in theaters before our next othersode. What did you think about season 2 of 'Westworld'? Email your thoughts to thesquad@booksquadgoals.com. Don't forget to rate, review and subscribe!0:36 – Intro question—what park would you want to visit?7:27 – Summary and spoiler warning 9:50 – Thoughts about this season in general25:00 – Nonlinearity and narrative27:08 – Interview with Lisa Joy (https://www.hollywoodreporter.com/live-feed/westworld-season-2-finale-explained-lisa-joy-season-3-1122744)33:00 – Linearity and character and comparisons to 'LOST'37:18 – Characterization and favorite characters 47:20 – Dolores!53:00 – Radiohead and music and the show57:11 – 'Solo' feedback1:06:00 – 'Hereditary' chat1:15:24 – What’s on the blog, what’s up next?
Join the #BookSquad in the dusty, violent old west as we take on season 2 of HBO's 'Westworld' and spoil literally everything. Find out what "world" squad members want to go to, how we think season 2 compares to season 1, who are favorite characters are, and what worked and didn't work this go-round. Also, what's a robutt? We read some great listener feedback about 'Solo' and 'Hereditary' (and therefore get spooked about 'Hereditary' all over again!). Plus, find out what's on the #BookSquadBlog and what's coming up on the next fullpisode! Read along with us for 'Super Extra Grande' by Yoss, and be sure to catch 'Sorry to Bother You' in theaters before our next othersode. What did you think about season 2 of 'Westworld'? Email your thoughts to thesquad@booksquadgoals.com. Don't forget to rate, review and subscribe!0:36 – Intro question—what park would you want to visit?7:27 – Summary and spoiler warning 9:50 – Thoughts about this season in general25:00 – Nonlinearity and narrative27:08 – Interview with Lisa Joy (https://www.hollywoodreporter.com/live-feed/westworld-season-2-finale-explained-lisa-joy-season-3-1122744)33:00 – Linearity and character and comparisons to 'LOST'37:18 – Characterization and favorite characters 47:20 – Dolores!53:00 – Radiohead and music and the show57:11 – 'Solo' feedback1:06:00 – 'Hereditary' chat1:15:24 – What’s on the blog, what’s up next?
Does my string bed get stiffer as I hit the ball harder?
Messiah Marcolin or Rob Lowe? Boring question. Both phenomenal and part of the great legacy of Candlemass. Ben continues the journey with reflections, readings from the likes of Caleb Wilde to the classic poem "Kindness" by Naomi Shihab Nye..As well as our human bond to the ancient stars...Linearity also be damned: Reaching forward from Rob Lowe era Candlemass to young and killer Crypt Sermon sbd their stunning vocalist Brooks Wilson...Enjoy!
Do all games have to let us shape the world? Josh talks the power of linear narratives in movies and games. --- Send in a voice message: https://anchor.fm/intelligameus/message
Today on the 5: Game outlets have recently been given the first 2 hours of the new God Of War game to play and report on. While they all seem generally favorable, one curious compliant is that the game is very linear.
42 Minutes 303: Jonathan Evison - This Is Your Life, Harriet Chance! 02.12.2018 In anticipation of Treefort Music Fest, the program reconnects with Jonathan Evison discussing his novel, Harriet Chance. He appears this year at Storyfort Friday and Saturday evening for three events. Topics Include: Treefort, Storyfort, Reinvention, West Of Here, Anna Karenina, Partenership, Mrs Daisy, Memory, Linearity, Revelation, Marginalized, William Melvin Kelly, Zeitgeist, Me Too, Class, Commerce, Algonquin Books, Process, Stewart O'Nan, Willy Vlautin, The Record Exchange, Lidia Yuknavitch, Big Foot, Cave Dave, Mt St Helens. Treefortmusicfest.com
Topics: Ship Of Theseus, VM Straka, JJ Abrams, Lost, The Swerve, Lucretius, Coincidence, Mystical, In Between, Simultaneity, Synchronicity, Discovery, Challenge, Design, Characterization, Linearity, Old Books, Digital Culture, Marginalia, 19, Thought Experim...
42 Minutes 275: Doug Dorst - S. - 05.16.2017 Though there is only so much mystery a person can handle at once, particularly when one is buried in all of it, we nonetheless set sail, bound for adventure, aboard a book: a chronicle of two readers finding each other, and their deadly struggle with forces beyond their understanding and we do so with the author's author, Doug Dorst. Topics Include: Ship Of Theseus, VM Straka, JJ Abrams, Lost, The Swerve, Lucretius, Coincidence, Mystical, In Between, Simultaneity, Synchronicity, Discovery, Challenge, Design, Characterization, Linearity, Old Books, Digital Culture, Marginalia, 19, Thought Experiment, Identity, Improvisation, Transcendence, Shared Narrative, Flow State. http://amzn.to/2rgSgPg
Welcome to Average Gamer, The podcast for gamers by gamers. In episode five we cover a variety of topics such as Nvidia's CES keynote disaster, why is linearity in video games viewed as a negative and lastly we share some though and predictions on the Nintendo Switch launch event. Did I forget to mention that we have free games this episode? oops :) ►YouTube - Sully https://www.youtube.com/channel/UCxpoX5TooTdIhZ8p9QBPasg ►Follow Sully https://twitter.com/1OneGuysOpinion ►YouTube - Joe https://www.youtube.com/channel/UC5VZEAlAZclQOkRxkhF_7rw ►Twitter - Joe https://twitter.com/joe_ch1p ►YouTube - Grant https://www.youtube.com/channel/UCfoTQUr4Il5eFBkKV6WgLzg ►Twitter - Grant https://twitter.com/OverTheEdgeYT
If I do the right things am I guaranteed the right results? Is there a "Law of Linearity" which confirms if you do "A" you will automatically get "B"? Or is this a false hope? Are there actually no guarantees in this life? This is what the Teacher explores in the second half of Ecclesiastes 7.
If I do the right things am I guaranteed the right results? Is there a "Law of Linearity" which confirms if you do "A" you will automatically get "B"? Or is this a false hope? Are there actually no guarantees in this life? This is what the Teacher explores in the second half of Ecclesiastes 7.
If I do the right things am I guaranteed the right results? Is there a "Law of Linearity" which confirms if you do "A" you will automatically get "B"? Or is this a false hope? Are there actually no guarantees in this life? This is what the Teacher explores in the second half of Ecclesiastes 7.
Justin squared, Alex, and Liz get together to chat Switch, new games, and game linearity.
Did someone say Fallout? The crew goes in-depth into the Fallout 4 announcement, a bit on MMOs, and much more this week.// Comments? Questions? ANSWERS? Fqpodcast@gmail.com// 0:00:53 - Fallout 4 Hype// 0:31:25 - Halo 3 ODST - What side stories would you want to see?// 0:44:28 - Europa Universalis 4 (cont)// 0:58:30 - Learning Curves in relation to enjoyment// 1:12:07 - Final Fantasy XIV// 1:21:07 - Console MMO's and their impact// 1:31:36 - The Future of MMO's// 1:44:12 - Tomb Raider (1996)// 1:48:28 - Eurotruck Simulator, Spintires (cont)// 1:50:16 - Bioshock Series// 2:01:10 - Wolfenstein: The Old Blood (cont)// 2:15:12 - Linearity in FPS Single Player Campaigns// 2:30:30 - Darkest Dungeon, and the effect of Early Access// 2:39:54 - FMV in Video Games// 2:45:46 - IN THE NEWS, The PC Gaming Show// 2:49:48 - Dark Souls 3 Rumors// 2:55:26 - Advent Future & X-Com 2// 3:02:22 - Steam Return Policy Change// 3:04:59 - Hunt the Truth Episode 10// 3:07:24 - Listener Mail// 3:16:51 - Dragon Age Origins, 2 Light Spoilers// 3:20:14 - The Wrap-Up
Today, we talk about the difference between a linear game and an open world game, as well as the traits that define them. These two go hand in hand when creating the experience you want a player to have in a game.
Mathematics and Physics of Anderson Localization: 50 Years After
Finkelstein, A (Weizmann Institute and Texas A&M University) Monday 17 September 2012, 10:10-10:50
Herb Gross considers linearity in spaces of greater than 2 variables including a discussion of local linearity.
What Are We Playing?:Jeff is behind on the times, but finally finished Bioshock 1.Michael hates basic physics, but loves Dead Rising 2 wheelchairs and snow (this was recorded back in February)Mark knows some fancy Japanese games. Isn't he special? If you want the titles...good luck with that. One is called 3D World Runner in EnglishMain Topic: Open World vs. LinearMichael gets some knowledge dropped on him on open world gamesIf we have any disabled listeners, we apologize greatlySTRENGTH OPEN WORLD: ImmersionCuttlefishWEAKNESS OPEN WORLD: So big, players are unaware of how things workSTRENGTH OPEN WORLD: Creation of Player PlotsSTRENGTH LINEAR WORLD: Meaning Behind The Plot, and a lack of Jimmy McWaffleboysWEAKNESS USER-CREATED CONTENT (?): Cavaclade of CrapSTRENGTH LINEAR WORLD: Much Stronger Story than a User-Made OneEternal Pac-Man? Pacternal Darkness? Wakka Wakka Wakka Insanity?STRENGTH LINEAR GAMES: Possible Sanity QuestioningOPEN WORLD NECESSITY: Need for Universal SignalsWEAKNESS OPEN WORLD: Lack of Urgency, and Vice Versa with Linear WorldSide Tangent on Being TimedSTRENGTH OPEN WORLD: Openness in Choices (Durr)STRENGTH LINEAR GAMES: Importance of the Player's Actions IncreasesNECESSITY LINEAR GAMES: Character SympathySTRENGTH ALL: MoralityReplayabilitySTRENGTH LINEAR GAMES: Dependency on the NarrativeWEAKNESS LINEAR GAMES: DependencyLinearity in Role-Playing Games"In a Video Game, the game provides the go, the player provides the do. In an RPG, the player provides the go, and the GM provides the do."-Mark Snyder"The more the GM tightens his grip, the more players will slip through his fingers"-Jeff Bailey stealing from Star Wars: The New HopeWins and FailsMark:+ Youtube dropping time limit- Having watched two and a half hours of Worms (Dude, seriously?)+ Apology Win to Every RPG ever made- Him reading every RPG in a new lightMichael:+ Game Informer's Replay of Overblood+ Ridiculous Texas Snow- Green Lanturn (2011) and Ryan Reynolds- WHO CARES ABOUT THE SUPER BOWL WOOOOOOOOJeff:+ Visceral Studios for throwing in Extraction with Dead Space 2+ Xynga for being like crack cocaine and SUCKING YOU BACK IN- Google Docs for censorshiposity- Indie RPG Movement for obliterating any ability for Jeff to keep track of news
In today’s episode: Lani and Alastair continue Process Week by talking about linear and non-linear writing. StoryWonk Daily is brought to you by Lani Diane Rich and Alastair Stephens, and is a StoryWonk production. Send your questions and comments to podcast@storywonk.com. Download the mp3, and subscribe to the show via RSS or find us on iTunes. Space is still available in Lani’s Discovery and Revision […]
FmLuder, gk128 and Binary667 are on the show this week. Luder talks DLC Mass Effect 2: Kasumi - Stolen Memory. And he considers the high possibility that Kasumi Goto will probably make it into mass Effect 3 in a significant way. Binary667 goes in a straight line and finds that he enjoys it. Linearity and games is the topic brought to the table by Binary. gk128 discusses Mega Man 10. He is after something different in retro re-makes and Mega Man 10 is a bit of a let down.
What on earth is the Out-Cast? Well, this was a series of podcasts I did back in 2010~2012 on videogames and videogame culture in Japan for an old website with a completely different crew. I'm republishing them here on DecultureShock, but for anyone who is interested, the original website can be found here. http://www.decultureshock.com/wp-content/uploads/2017/02/The-Out-Cast-ep03.mp3 Welcome to our third regular episode of the outcast. This one runs for a bit over two and a half hours and we look in-depth at Yakuza 3 and 4 as well as into other gaming news from around the world. Download below and please leave us any comments on how we can improve this podcast. Thanks for listening. Introduction 0:00: Introduction What you been doing? 01:37: Richard Disappearance of Haruhi Miles Edgeworth: Ace Attorney Investigations Tomb Raider Underworld Heavy Rain 18:40: Gwyn Fist of the North Star Dynasty Warriors Shoko-Tan Resident Evil 5: Desperate Escape Gundam Unicorn May'n Consent DVD 32:00: Kyle X-Box Live Bioshock Banjo Kazooie Fatal Frame 4 Metal Gear Solid: Peace Walker PS1 Archives: Metal Gear Solid/Grandia 47:45: News Tomodachi Collection Playstation Move Hatsune Miku 1:03:05: Final Fantasy XIII Western Release/Response Critics and complaints Linearity Cuts Names 1:11:28: SPECIAL GUEST! FFXIII and the process of making a game More on Linearity! The JRPG vs the Western RPG 1:26:30: Yakuza 3 Cuts, boycotts, and the history of the series Is the west entitled to all Japanese games? Name of the game 1:47:54: Yakuza 4 New features New characters Demo play-by-play Real to life? 2:13:00: Let's E-Mailing! How was XIII received in Japan? Why EoE name change? What's with the Asian peace sign? How is P3 different from P3 - PSP? How was FFXIII's Crystarium System? How does Japan compare to the west? What was the first song in Out-Cast ep02? Do we listen to 1UP podcasts? Have we played Dragon Quest IX? Song list Butterfly City - Zeebra Don't Say Lazy - Shokotan (cover) Encounter - Metal Gear Solid 2 Yakuza kicking yo' a$$! Yakuza 4 tv cm Miku Miku ni shite ageru - Hatsune Miku God knows... - Shokotan (cover)
What on earth is the Out-Cast? Well, this was a series of podcasts I did back in 2010~2012 on videogames and videogame culture in Japan for an old website with a completely different crew. I'm republishing them here on DecultureShock, but for anyone who is interested, the original website can be found here. http://www.decultureshock.com/wp-content/uploads/2017/02/The-Out-Cast-ep00.mp3 This is our first episode of our new Podcast, The Out-Cast, where we talk in depth about Final Fantasy XIII. It clocks in at 93 minutes. Download it below and please leave us your comments. 00:00: Introduction 04:47: Personal History With Final Fantasy 11:26: Why is Final Fantasy XIII Important and the Japanese Market 17:49: Linearity and Comparisons to Other Final Fantasys 27:07: Game-play of Final Fantasy XIII 39:13: The Good Things and the Bad 47:11: Characters and Localization Issues 69:55: Voice Acting, Translation, and Music 83:41: Final Thoughts Note: When talking about the "black stereotype" in Japan I was actually thinking of Bobby Olugun, not Bob Sapp, in that "son's question" television anecdote. Correction by Dan Feit.
Background: Cancer antigen CA125 is known as a valuable marker for the management of ovarian cancer. Methods: The analytical and clinical performance of the Access OV Monitor Immunoassay System (Beckman Coulter) was evaluated at five different European sites and compared with a reference system, defined as CA125 on the Elecsys System (Roche Diagnostics). Results: Total imprecision (%CV) of the OV Monitor ranged between 3.1% and 8.8%, and inter-laboratory reproducibility between 4.7% and 5.0%. Linearity upon dilution showed a mean recovery of 100% (SD+8.1%). Endogenous interferents had no influence on OV Monitor levels (mean recoveries: hemoglobin 107%, bilirubin 103%, triglycericles 103%). There was no high-dose hook effect up to 27,193 kU/L. Clinical performance investigated in sera from 1811 individuals showed a good correlation between the Access OV Monitor and Elecsys CA125 (R = 0.982, slope = 0.921, intercept = + 1.951). OV Monitor serum levels were low in healthy individuals (n = 267, median = 9.7 kU/L, 95th percentile = 30.8 kU/L), higher in individuals with various benign diseases (n = 549, medians = 10.9-16.4 kU/L, 95th percentiles = 44.2-355 kU/L) and even higher in individuals suffering from various cancers (n = 995, medians= 12.4-445 kU/L; 95th percentiles = 53.4-4664 kU/L). Optimal diagnostic accuracy for cancer detection against the relevant benign control group by the OV Monitor was found for ovarian cancer {[}area under the curve (AUC) 0.898]. Results for the reference CA125 assay were comparable (AUC 0.899). Conclusions: The Access OV Monitor provides very good methodological characteristics and demonstrates an excellent analytical and clinical correlation with Elecsys CA125. The best diagnostic accuracy for the OV Monitor was found in ovarian cancer. Our results also suggest a clinical value of the OV Monitor in other cancers.
Background: Gastrointestinal cancer antigen CA19-9 is known as a valuable marker for the management of patients with pancreatic cancer. Methods: The analytical and clinical performance of the Access(R) GI Monitor assay (Beckman Coulter) was evaluated on the UniCel(R) Dxl 800 Immunoassay System at five different European sites and compared with a reference method, defined as CA19-9 on the Elecsys System (Roche Diagnostics). Results: Total imprecision (%CV) of the GI Monitor ranged between 3.4% and 7.7%, and inter-laboratory reproducibility between 3.6% and 4.0%. Linearity upon dilution showed a mean recovery of 97.4% (SD+7.2%). Endogenous interferents had no influence on GI Monitor levels (mean recoveries: hemoglobin 103%, bilirubin 106%, triglycerides 106%). There was no high-dose hook effect up to 115,000 kU/L. Clinical performance investigated in sera from 1811 individuals showed a good correlation between the Access' GI Monitor and Elecsys CA19-9 (R = 0.959, slope = 1.004, intercept +0.17). GI Monitor serum levels were low in healthy individuals (n = 267, median = 6.0 kU/L, 95th percentile = 23.1 kU/L), higher in individuals with various benign diseases (n = 550, medians = 5.8-13.4 kU/L, 95th percentiles = 30.1-195.5 kU/L) and even higher in individuals suffering from various cancers (n = 995, medians = 8.4-233.8 kU/L, 95th percentiles = 53.7-13,902 kU/L). Optimal diagnostic accuracy for cancer detection against the relevant benign control group by the GI Monitor was found for pancreatic cancer {[}area under the curve (AUC) 0.83]. Results for the reference CA19-9 assay were comparable (AUC 0.85). Conclusions: The Access(R) GI Monitor provides very good methodological characteristics and demonstrates an excellent analytical and clinical correlation with the Elecsys CA19-9. The GI Monitor shows the best diagnostic accuracy in pancreatic cancer. Our results also suggest a clinical value of the GI Monitor in other cancers.
Background: Cancer antigen CA15-3 antigen is known as a valuable marker for the management of breast cancer. Methods: The analytical and clinical performance of the Access' BR Monitor Immunoassay System (Beckman Coulter) was evaluated at five different European sites and compared with a reference system, defined as CA15-3 on the Elecsys(R) System (Roche Diagnostics). Results: Total imprecision (%CV) of the BR Monitor ranged between 5.5% and 11.7%, and inter-laboratory reproducibility between 3.4% and 5.1%. Linearity upon dilution showed a mean recovery of 98.5% (SD+/-9.1%). Endogenous interferents had no influence on BR Monitor levels (mean recoveries: hemoglobin 112%, bilirubin 111%, triglycerides 108%). There was no high-dose hook effect up to 13,540 kU/L. Clinical performance investigated in sera from 1811 individuals showed a general correlation between the Access BR Monitor and Elecsys CA15-3 (R = 0.797), with a slope of 1.383. CA15-3 serum levels, as measured by the BR Monitor, were low in healthy individuals (n = 267, median = 11.9 kU/L, 95th percentile = 23.5 kU/L), higher in individuals with various benign diseases (n = 549, medians = 11.3-15.6 kU/L, 95th percentiles = 21.6-54.6 kU/L) and even higher in individuals suffering from various cancers (n = 995, medians = 11.2-22.8 kU/L, 95th percentiles = 30.0-429.7 kU/L). Best diagnostic accuracy for cancer detection against the relevant benign control group by the BR Monitor was found for locoregional and metastatic breast cancer, as well as for ovarian cancer {[}area under the curve (AUC) 0.619, 0.897 and 0.774]. Results for the reference CA15-3 assay were comparable (AUC 0.611, 0.887 and 0.818). Conclusions: The Access BR Monitor provides accurate methodological characteristics and demonstrates an analytical and clinical correlation with Elecsys CA15-3. Best diagnostic accuracy for the BR Monitor was found in breast and ovarian cancer. Our results also suggest a clinical value of the BR Monitor in other cancers.
Guest speakers: Terence McKenna, Ralph Abraham, and Rupert Sheldrake PROGRAM NOTES: (Minutes : Seconds into program) 05:40 Terence McKenna: "Going back to this thing about language, you get this same peculiar emphasis on language and letters in the esoteric doctrine that surrounds the chakras." 06:57 Terence: "Linearity in print conferred upon language an inability to deal with the invisible world in any meaningful way, and so it just became pathology, but now it's returning, and people such as ourselves who have one foot in each world have a real obligation to cognize this and move it forward." 09:55 Ralph Abraham: "There is very little discussion of the intelligent science, mythology, and so on of these 100-, 200-, 300-thousand B.C., what is going on during these previous interglacials, and it could be that there was agriculture. There would be no way to rule that out." 15:30 Rupert Sheldrake: "If that's possible [communicating with a star entity], what kind of information would such beings impart?" 17:27 Ralph: "Myth is from mythos. Mythos meant the lyrics, the words of the song from the rituals. Myth gained the power it now has in our conscious and unconscious life through its secondary role in the ritual. The ritual and the myth together, I think, is one of the most important things for us to regain." 19:11 Ralph: "Peace [in Crete], I think, was not produced by just a partnership paradigm in a lucky society to have escaped the bad habits of the dominator paradigm. There was also the conscious interaction with the peaceful initiative of the celestial sphere in bringing peace down." 22:12 Terence: "I think when you go to the edges . . . then you discover there is an extremely rich flora and fauna in the imagination that has simply been ignored because our tendency has always been to look inward, to build inward, and to turn our backs on the raging ocean of phenomenon around us that entirely overwhelms our metaphors." 25:02 Rupert: "The spirit of Satan is the spirit of self-sufficiency, of being in charge, and the spirit of denial of the whole other realm. . . . So the guiding spirit of modern science, according to the Faust myth, is a demon. It's in fact a Satanic demon, a fallen angel, Mephistopheles. . . . How seriously does one need to take the idea that our whole society and civilization may be under the possession of such a spirit, worship through money?" 28:34 Rupert: "If we take seriously these entities, how much can we admit the possibility that there are these malevolent entities, like Mammon or Satanic powers or fallen angles, which are actually guiding and perverting the progress of science and technology?" 30:50 Terence: "Probably the process of civilization is going to reveal the final status of this shadow within us." 36:12 Ralph: "I think we need the Gaian, and we need the Chaotic, that is the celestial sphere, to be re-connected, to be coupled, to the human spirit . . . that is the ultimate partnership." Download MP3 PCs – Right click, select option Macs – Ctrl-Click, select option
Background: Measurement of late-night salivary cortisol concentrations is increasingly used as a screening test in suspected Cushing's syndrome. Cortisol concentrations are typically extremely low in late-night samples and discordant assay-specific reference ranges have been reported. Therefore, the aim of our study was to assess the analytical performance of the first automated cortisol immunoassay specified for salivary measurements and to establish late-night sampling reference-range data for this test. Methods: Salivary cortisol was measured using the Roche Cobas Cortisol assay (Roche Diagnostics). Five salivary pools in different concentration ranges were used to assess the inter-assay imprecision of this test in a two-centre evaluation protocol including two reagent lots. Linearity was tested by serial dilution. Salivary samples were obtained at 23:00 h from 100 apparently healthy volunteers using a commercially available salivary sampling device (Salivette, Sarstedt). A subset of 20 samples was used for method comparison with isotope dilution liquid chromatography-tandem mass spectrometry. Results: Inter-assay coefficients of variation (n=20) between 11.6% and 40.4% were found for mean cortisol concentrations between 12.9 and 2.6 nmol/L, with an estimated functional sensitivity of approximately 5.0 nmol/L. The test also gave linear results in the lowest concentration range between 1.0 and 8.3 nmol/L. Mean late-night salivary cortisol of 5.0 nmol/L was found for healthy individuals; the absolute range was 1.4-16.7 nmol/L, and the 95th percentile was 8.9 nmol/L. Substantially lower concentrations were found with isotope dilution LC-MS/MS compared to immunoassay results (mean concentrations 1.8 and 4.4 nmol/L, respectively). Conclusions: The automated assay investigated was found to offer acceptable analytical performance in the very low concentration range required for late-night salivary cortisol, despite a very short turnaround time. Using this assay, late-night salivary cortisol concentrations below 8.9 nmol/L are typically found in healthy volunteers.
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