Podcasts about ammirati

12ème épisode : Valérie Ammirati découvre la comptabilité lors de ses études en École de commerce et décide d'orienter sa carrière vers l'expertise comptable.

Continua il progetto Contemporaneamente podcast che dal 2020 ha messo insieme oltre 250 autori di grande rilievo internazionale, tra arte e scienze, stem, filosofia, economia, storia, architettura, sport, cinema, musica, e molto altro. In itinere altri progetti per approfondire questioni auliche ma anche cogenti e futuribili, attraverso il pensiero dei maggiori interpreti del contemporaneo. In questo audio il prezioso incontro con Alessandro Bergonzoni artista e scrittore, e Maria Pia Ammirati direttore Rai Fiction. L'intervista è in Contemporaneamente di Mariantonietta Firmani, il podcast divulgato da Parallelo42.it, Artribune.com e Treccani.it.Alessandro Bergonzoni, e Maria Pia Ammirati ci raccontano di parole e programmi, palinsesti e tealtro. È importante tutto ciò che è congiunto, ciò che fa vedere gli sfuocati, e sono le parole che giocano con noi, è necessario capolavorare. Capita che passione e mestiere non coincidano, pur salvaguardando la qualità di entrambi, la complessità del pensiero informa la nostra vista. È una questione quantistica, con il sorriso le cellule danzano con la pesantezza le cellule si radunano. Inoltre, c'è differenza tra narrazione seriale e intrattenimento è nella scrittura che definisce profondità e qualità; scrittura che manca nell'intrattenimento. Quindi, dobbiamo diventare sovrumani, come possiamo tornare umani se forse non lo siamo mai stati? E molto altro. ASCOLTA L'INTERVISTA INTEGRALE!! GUARDA IL BREVE VIDEO!! su Youtube https://youtu.be/WUgRIPmE6hs BREVI NOTE BIOGRAFICHE DEGLI AUTORI Alessandro Bergonzoni, Artista, attore, autore. Quindici spettacoli teatrali al suo attivo e sei libri. Nel cinema: "Pinocchio" (2001) di Roberto Benigni e "Quijote" (2006) di Mimmo Paladino. Da anni scrive "Aprimi Cielo" una rubrica sul Venerdì di Repubblica e "Il pensato del giorno" su Robinson.Dal 2005 si avvicina al mondo dell'arte esponendo in varie gallerie e musei. Unisce al suo percorso artistico un interesse profondo per i temi legati al coma, alla malattia, al mondo carcerario, tenendo su questi argomenti incontri in vari ambiti. Ha vinto il Premio della Critica 2004/2005, il Premio Hystrio nel 2008 e il Premio UBU nel 2009. Parallelamente allo spettacolo "Trascendi e sali" ha presentato in varie Pinacoteche Nazionali l'installazione performativa "Tutela dei beni: corpi del (C)reato ad arte (il valore di un'opera, in persona)". Inotre, nel 2020 esce "Aprimi cielo, dieci anni di raccoglimento, articolato". Nel 2022 gli viene assegnata la Coppa Volponi per il lavoro letterario e il Premio Nazionale Cultura della Pace-Città di Sansepolcro per l'azione civile in difesa della non violenza e dell'aiuto ai migranti. Nel 2023 gli viene consegnato per la sua multiforme attività artistica il Premio Montale Fuori di Casa sez. Satura. Maria Pia Ammirati, direttore Rai Fiction è dirigente televisiva, scrittrice e giornalista; dopo esperienze come giornalista e critico militante entra in Rai nel 1992. Dal 1993 si occupa di programmi radiofonici e televisivi come programmista-regista, autrice e conduttrice.Nel 2000 passa dalla Direzione Educational a Rai 1 dove lavora come Capo Segreteria di Rete, Capo progetto, Capostruttura e Vice Direttore. Si occupa in particolare di programmi Daytime spesso firmandosi come autrice. Nel 2011 come Vicedirettore segue tutto il Daytime di Rete. Dal 2014 al 2020 è Direttore di Rai Teche. Dal 2016 al 2019 le viene assegnata la responsabilità del Content RaiPlay. Nel novembre 2020 viene nominata Direttore della Direzione Fiction. È autrice di romanzi e di numerose pubblicazioni. Ha ricevuto diversi riconoscimenti, tra cui: Selezione al Premio Strega 2001, Selezione Premio Campiello 2011, Premio Procida, Premio Basilicata.  Per il lavoro nel mondo dell'intrattenimento ha ricevuto Premio Rodolfo Valentino 2014 Italian Excellence, organizzato dalla Fondazione Rodolfo Valentino. È membro di numerose giurie letterarie, tra cui Premio Strega e Premio Viareggio. È Consigliere di Amministrazione del Teatro dell'Opera di Roma.

We have unlocked the full and unedited subscriber version of episode four which we released on August 22 for Premium subscribers of The Ken and on Apple Podcasts. Now you can stream it wherever you listen to your podcasts for free for a few weeks.Software engineering careers used to be a ladder. You studied for 4 years, got a job as a fresher, and could virtually take for granted a steady career filled with learning opportunities, salary hikes, and role promotions.In fact being an engineer was so cool that we mocked MBAs and MBA-types – “suits” – for their desperation to find that elusive technical co-founder. The one who would translate an idea (common) into code and products.Except, that's increasingly not true.An NYT story published earlier this week put it best.“I have a pretty good sense how fast the progress that students should make in a semester should be,” he said. “In 14 years, I've never seen students make the kind of progress that they made this year.”And he knew exactly why that was the case. For the first time, Mr. Ammirati had encouraged his students to use generative artificial intelligence as part of their process — “think of generative A.I as your co-founder,” he recalled telling them.Many AI chatbots are fully capable of writing code now. So your technical co-founder could be an AI?Where does that leave engineers? Are we staring at the end of the golden era for engineers?Welcome to episode six of Two by Two, The Ken's weekly podcast that asks the most interesting and often uncomfortable questions on topics we all want to know more about. And we do that through the lens of a 2×2 matrix!Earlier this week, Praveen Gopal Krishnan, my co-host, and I met with Amod Malviya, co-founder of Udaan and the former CTO at Flipkart, and Kailash Nadh, CTO at Zerodha*.Both Amod and Kailash have been programmers and engineers for over two decades now. They are also both deeply in love with their craft. Naturally, they are passionate about engineering and have strong views on its future.Additional Reading:Computational Thinking by Jeannette M. WingThe Art of Doing Science and Engineering by Richard HammingThis episode of Two by Two was produced by Anushka Mukherjee. Hari Krishna is the lead writer and researcher for this episode. Rajiv C N, our resident sound engineer is the audio producer.Please rate, share and follow us on your favorite streaming platform. It helps more like-minded people like you to find out by Two by Two.*Zerodha's perennial fund Rainmatter Capital is an investor in The Ken.

Software engineering careers used to be a ladder. You studied for 4 years, got a job as a fresher, and could virtually take for granted a steady career filled with learning opportunities, salary hikes, and role promotions.  In fact being an engineer was so cool that we mocked MBAs and MBA-types – “suits” – for their desperation to find that elusive technical co-founder. The one who would translate an idea (common) into code and products.Except, that's increasingly not true.An NYT story published earlier this week put it best.“I have a pretty good sense how fast the progress that students should make in a semester should be,” he said. “In 14 years, I've never seen students make the kind of progress that they made this year.”And he knew exactly why that was the case. For the first time, Mr. Ammirati had encouraged his students to use generative artificial intelligence as part of their process — “think of generative A.I as your co-founder,” he recalled telling them.Many AI chatbots are fully capable of writing code now. So your technical co-founder could be an AI?Where does that leave engineers? Are we staring at the end of the golden era for engineers?Welcome to episode six of Two by Two, The Ken's weekly podcast that asks the most interesting and often uncomfortable questions on topics we all want to know more about. And we do that through the lens of a 2×2 matrix!Earlier this week, Praveen Gopal Krishnan, my co-host, and I met with Amod Malviya, co-founder of Udaan and the former CTO at Flipkart, and Kailash Nadh, CTO at Zerodha*.Both Amod and Kailash have been programmers and engineers for over two decades now. They are also both deeply in love with their craft. Naturally, they are passionate about engineering and have strong views on its future.[You can listen to the full episode on The Ken's app or on Apple Podcasts, with a paid subscription]Additional Reading:Computational Thinking by Jeannette M. WingThe Art of Doing Science and Engineering by Richard HammingThis episode of Two by Two was produced by Anushka Mukherjee. Hari Krishna is the lead writer and researcher for this episode. Rajiv C N, our resident sound engineer is the audio producer.Please rate, share and follow us on your favorite streaming platform. It helps more like-minded people like you to find out by Two by Two.*Zerodha's perennial fund Rainmatter Capital is an investor in The Ken.

Com uma cerimônia memorável, a Olimpíada de Paris se encerrou no domingo (11), sendo aclamada como o evento esportivo mais espetacular de todos os tempos. Quebra de recordes, um desempenho inédito da França, sucesso das mulheres brasileiras, cenários de tirar o fôlego, polêmicas e muitos memes: os Jogos Olímpicos de Paris serão lembrados por uma série de façanhas e fatos.  Daniella Franco, da RFITudo começou com uma cerimônia de abertura grandiosa, com duração de três horas e meia – a primeira em toda a história das Olimpíadas realizada fora de um estádio, com o rio Sena e monumentos como pano de fundo. A festa também foi marcada pela performance de grandes estrelas, como a cantora canadense Céline Dion, que, depois de muito suspense e especulações, interpretou “L'Hymne à L'Amour”, de Edith Piaf, na Torre Eiffel. A abertura dos Jogos Olímpicos de Paris deu o que falar pela beleza, mas também pela ousadia, já que uma das cenas do evento, confundida com a Santa Ceia, suscitou críticas de autoridades religiosas e líderes políticos conservadores em todo o mundo. Artistas e o diretor da cerimônia, Thomas Jolly, chegaram a ser alvo de ameaças de morte. Jolly precisou ir a público explicar que a passagem específica do evento nada tinha a ver com religião, e que teria sido inspirada na pintura “Festa dos Deuses”, obra criada no século 17 pelo holandês Jan Harmens Bilert. "Ninguém jamais encontrará no meu trabalho uma vontade de zombar ou de difamar. Eu quis fazer uma cerimônia para unir e também para reafirmar os valores da República Francesa - Liberdade, Igualdade, Fraternidade - e não para rir de quem quer que seja", afirmou, em entrevista ao canal BFMTV.Polêmicas envolvendo atletasAlgumas polêmicas também envolveram a participação de atletas nos Jogos Olímpicos de Paris. É o caso do jogador holandês de vôlei de praia, Steven van de Velde, condenado por estupro de menor de idade. Ele chegou a ser vaiado na quadra, inclusive pelo público brasileiro, na partida em que ele e seu colega de dupla, Matthew Immers, foram eliminados por Evandro e Arthur nas quartas de final. Já a boxeadora argelina Imane Khelif enfrentou boatos de que seria transgênero. A esportista, que tem hiperandrogenismo, viu sua participação nas competições femininas de Paris 2024 ser contestada. O caso chocou a Argélia, onde Khelif é um ícone. O Comitê Olímpico Internacional defendeu a atleta, que fez um apelo ao público antes de vencer a chinesa Yang Liu e conquistar o ouro na categoria - 66 kg."Envio essa mensagem a todas as pessoas no mundo, para aceitarem as regras e princípios olímpicos e pararem de atacar os atletas porque isso tem consequências, consequências graves", declarou em entrevista à agência American Press. "Esses ataques podem destruir as pessoas, espiritual e mentalmente. E isso divide as pessoas. Por isso, peço que parem com o bullying", disse Khelif.Outra polêmica ocorreu devido à quebra de recorde protagonizada pelo nadador chinês Pan Zhanle, que no dia 31 de julho cravou o tempo de 46:40 na final dos 100 metros do nado livre - um segundo a frente do australiano Kyle Chalmers, que levou a prata. Uma façanha como essa na natação não era vista há cerca de 50 anos, o que levou muitos especialistas a insinuarem a possibilidade de doping, não confirmada nos exames. Quebras de recordesA nadadora canadense prodígio Summer McIntosh, de apenas 17 anos, conquistou três ouros e uma prata nesta edição dos Jogos. Ela ainda registrou um novo tempo nos 200 metros borboleta (2:03:03). A jovem é vista como um dos grandes talentos de Paris 2024, três anos após sua estreia em Tóquio, quando tinha apenas 14 anos.No ciclismo de pista feminino, o recorde de velocidade foi batido cinco vezes em uma única noite, pela Grã-Bretanha, Alemanha, Nova Zelândia e depois duas outras vezes novamente pelas britânicas. Foram elas que levaram o ouro ao chegar à marca final de 45:186. O sueco Armand Duplantis emocionou o Stade de France com seu desempenho no salto com vara, alcançando 6,25 metros. Essa foi a nona vez que o atleta quebrou seu próprio recorde."Estou muito orgulhoso, definitivamente. Recebi mais amor e apoio do que poderia imaginar. Estou tão feliz que pude performar de uma maneira que eu sabia que era capaz. É mais incrível do que eu poderia imaginar, honestamente", declarou. Sucesso nas redes sociais Embora não tenha obtido o mesmo sucesso na competição, o atleta francês Anthony Ammirati viralizou nas redes sociais. Sua eliminação passaria despercebida não fosse sua genitália ter derrubado o sarrafo durante a disputa. Uma plataforma de conteúdo erótico chegou a propor o pagamento de € 250 mil para que o francês posasse diante de suas câmeras por uma hora. Em seu TikTok, Ammirati postou um vídeo em que aparece comendo, com o olhar distante, ao som da trilha sonora do desenho animado Bob Esponja e a seguinte mensagem: "quando você chama mais a atenção por sua genitália que por sua performance".Quem também viralizou nas redes sociais durante os Jogos Olímpicos de Paris foi Snoop Dogg, que se tornou um verdadeiro "mascote do evento". O rapper americano, que participou do revezamento da tocha olímpica, veio a Paris também como comentarista esportivo do canal NBC. Mas não apenas: a estrela experimentou vários esportes - judô, natação, esgrima e halterofilismo. Além disso, vídeos em que o músico aparece falando em francês e até dançando com um cavalo, em Versalhes, divertiram o público.Novas estrelas no mundo do esporteOs Jogos Olímpicos de Paris também entrarão para a história com a ascensão de novos ídolos do esporte. É o caso do nadador francês Léon Marchand, de 22 anos, que se tornou um herói na França ao conquistar cinco medalhas, quatro de ouro e uma de bronze. A RFI conversou com o jovem no estúdio instalado no Club France, espaço do Comitê Olímpico Francês no Parque de la Villette, norte de Paris. "Tenho consciência das minhas conquistas porque as pessoas não param de me perguntar sobre isso. Mas acho que, no fundo, ainda não me dei conta. Vai demorar um pouco, preciso de tempo. Os últimos dias foram muito intensos para mim. Então agora estou começando a voltar à realidade e a compreender o que aconteceu nesses últimos dias. E é uma coisa louca, na verdade", afirmou. O Brasil também fez história em Paris, com várias conquistas. Rebeca Andrade conquistou o primeiro ouro do país na ginástica artística e se tornou a maior medalhista brasileira de todos os tempos: foram quatro pódios apenas nessa Olimpíada, que se somam aos dois realizados em Tóquio. A ginasta de 25 anos conversou com a repórter Maria Paula Carvalho, da RFI, logo após obter o ouro na Arena Bercy e expressou orgulho com sua performance. "Estou muito feliz de estar voltando para o Brasil com o ouro. Os brasileiros mereciam muito! E eu queria muito também, sabe? Eu lutei muito e fiz o meu melhor" celebrou. Sucesso das brasileiras As mulheres brasileiras foram, pela primeira vez, mais numerosas que os homens na delegação nacional: 153 esportistas do sexo feminino contra 124 do masculino. Foram elas também que conquistaram a maioria das medalhas. Além de Rebeca Andrade, subiram no pódio Beatriz Souza e Larissa Pimenta no judô, Tatiana Weston-Webb no surfe, Rayssa Leal no skate street, Bia Ferreira no boxe, além da medalha por equipe da ginástica feminina, do vôlei de quadra, do vôlei de praia, com Ana Patrícia e Duda, e da equipe do futebol feminino, com essa foi a última Olimpíada de Marta. É também uma atleta mulher, a primeira representante do Brasil a disputar uma mesma edição dos Jogos Olímpicos e Paralímpicos, a mesatenista Bruna Alexandre, que avaliou as atletas nacionais. "É algo de muita alegria para o nosso país, ver que a mulher é forte e capaz. Quem sabe em Los Angeles, em 2028, tenha o dobro ou o triplo de esportistas mulheres", disse, em entrevista à RFI.O Brasil também subiu no pódio com William Lima e a equipe mista, no judô; Isaquias Queiroz, na canoagem; Gabriel Medina, no surfe; Augusto Akio, no skate park; Edival Pontes no taekwondo; e Caio Bonfim, na marcha atlética.Os brasileiros também marcaram presença em Paris, colorindo a torcida de verde e amarelo e fazendo muita festa nas arquibancadas e ruas da capital francesa. A gaúcha Roberta Calabro, radicada em Barcelona, veio à Paris assistir a algumas competições. Em entrevista à RFI, ela contou que a experiência foi tão positiva que resolveu prolongar a visita e ir até Marselha, no sul da França, ver a seleção feminina de futebol do Brasil enfrentar e bater a Espanha. "Participar das Olimpíadas sempre foi um sonho para mim, e essa em Paris, uma cidade que eu sempre amei, vai ficar marcada para sempre. Eu assisti a cinco jogos no total e eu fiquei impressionada com a organização. Foi incrível!", comemora.Paris se prepara para Jogos ParalímpicosNa noite de domingo (11), a França se despediu dos Jogos, mas temporariamente. A chama olímpica, exposta em um balão no Jardim das Tulherias, no centro de Paris, se apagou na noite de domingo, durante a cerimônia de encerramento. Mas ela voltará a ser acesa em 28 de agosto, quando iniciam os Jogos Paralímpicos. Enquanto isso, as autoridades francesas cogitam em transformar a escultura de 30 metros de altura e sete de diâmetro em um monumento, como uma lembrança física e permanente dos Jogos Olímpicos de Paris. Leia tambémEm contagem regressiva para Jogos Paralímpicos, atletas brasileiros embarcam rumo a Paris

There have been numerous reports and headlines online focusing on Anthony Ammirati's genitals, overshadowing the fact that the sensationalism surrounding his failed win has nothing to do with his manhood. According to a statement from a coach with 14 years of pole vault training, the issue was simply that “he did not have his maximum height over the crossbar.” Several coaches declined to comment, with one stating, “I am mortified by what is happening, and it's horrible for what is happening to this athlete.” Another coach, who has been coaching since 1975, remarked on the headlines, potential online sexual harassment, and a porn company offering $250,000 to a 21-year-old professional athlete and reserve police officer for the French National Police: “There's no place for any of this.” --- Support this podcast: https://podcasters.spotify.com/pod/show/steven-cuoco/support

ICYMI: Hour Two of ‘Later, with Mo'Kelly' Presents – Wellness Wednesday with wife, mother, fitness expert, and masterful storyteller Claudine Cooper sharing tips for ‘National Wellness Month' and MORE…PLUS – Thoughts on Adult Entertainment company CamSoda's $250K job offer to French Pole Vaulter Anthony Ammirati as a result of his viral Olympic bulge AND the arrest of Rapper Nelly for possession of ecstasy - on KFI AM 640…Live everywhere on the iHeartRadio app

TICKETS ARE OFFICIALLY ON SALE FOR OUR FALL TOUR! GET 'EM AT WHOWEEKLY.US/LIVE. CODY SIMPSON'S GIRLFRIEND IS THE FASTEST SWIMMER IN AUSTRALIA! KALEY CUOCO'S EX-HUSBAND WON BRONZE IN EQUESTRIAN TEAM JUMPING! THIS ITALIAN GUY'S DICK PREVENTED HIM FROM WINNING ANYTHING IN THE HIGH JUMP! (OR DID IT...) ANYWAY, THE VANDPUMP GIRLIES ARE ACTING UP, BEN PLAT LOVES UNCRUSTABLES, EMMA HERNAN'S GOT A SECRET TALENT, THE IMDBOAT GAVE AL*X*NDR* D*D*RRIO AN AWARD? ALSO JWOWW DIRECTED A HORROR FLICK, ANNA FARIS' STEPDAUGHTER POSTED HER, THERE'S A FUNDRAISER BOAT THE ORCAS ARE DEFFF COMING FOR,... PLUS, TOBEY'S GF IS 24 NOT 20! THE TOM CRUISE HAS A NEW TABLOID LOVE INTEREST, MARCUS AND LARSA ARE IN LOVE AGAIN (NOT WITH EACH OTHER) AND RITA'S HANGING WITH JODI! XOXO As always, call in at 619.WHO.THEM to leave questions, comments & concerns for a future episode of Who's There?. Get a ton of bonus content over on Patreon.com/WhoWeekly and COME SEE US LIVE THIS FALL! Grab tickets at http://www.whoweekly.us/live. To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

In this edition of Trendtral Park Bear Murder Mystery, Jack and Miles discuss their respective weekends, Anthony Ammirati's bulge costing him an Olympic medal, the return of dumbphones, Trump's concerted effort to steal the election… again, RFK's bonkers Central Park bear story, the misleading transphobic panic over a women's boxing match at the Olympics  and much more!See omnystudio.com/listener for privacy information.

Cinema, teatro, podcast, serie tv: il curriculum dell'ospite di questa puntata, definito da lei stessa "schizofrenico", è la dimostrazione di come si possa avere una carriera importante senza rimanere fossilizzati in un ruolo o in un solo ambito espressivo. Benvenuta nel "mondo di Manuel" ad Anna Ammirati. Playlist: St. Vincent - "Broken Man" Brittany Howard - "Earth Sign"

Dal truck di Radio Number One in Corso Imperatrice a Sanremo sono stati intervistati Walter Vacchino, proprietario del grande Teatro Ariston, e Luca Ammirati, scrittore e responsabile della sala stampa del Festival. Il 16 gennaio è uscito il loro nuovo libro La scatola magica di Sanremo, che racconta la storia del Teatro e del Festival. «Mio padre aveva il sogno di costruire un grande teatro - ha raccontato Vacchino ad Andrea Ferrari e Alessandra Valtolina - e questo desiderio si è avverato nel 1963 con l'inaugurazione dell'Ariston». Nel libro vengono raccontati tanti retroscena del Festival di Sanremo nel corso degli anni. «Ho avuto la fortuna di raccogliere il patrimonio di testimonianze del Festival - ha continuato Ammirati - e ho scoperto tante curiosità interessanti».

Ariston. La scatola magica di Sanremo, di Walter Vacchino e Luca Ammirati, è il protagonista dell'episodio di TuttoLibri di Liliana Russo

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Nel nuovo episodio di TuttoLibri, la nostra Liliana Russo presenta Tutti i colori tranne uno di Luca Ammirati

Gesù disse ai suoi discepoli: «State attenti a non praticare la vostra giustizia davanti agli uomini per essere ammirati da loro, altrimenti non c'è ricompensa per voi presso il Padre vostro che è nei cieli. Dunque, quando fai l'elemosina, non suonare la tromba davanti a te, come fanno gli ipòcriti nelle sinagoghe e nelle strade, per essere lodati dalla gente. In verità io vi dico: hanno già ricevuto la loro ricompensa. Invece, mentre tu fai l'elemosina, non sappia la tua sinistra ciò che fa la tua destra, perché la tua elemosina resti nel segreto; e il Padre tuo, che vede nel segreto, ti ricompenserà.E quando pregate, non siate simili agli ipòcriti che, nelle sinagoghe e negli angoli delle piazze, amano pregare stando ritti, per essere visti dalla gente. In verità io vi dico: hanno già ricevuto la loro ricompensa. Invece, quando tu preghi, entra nella tua camera, chiudi la porta e prega il Padre tuo, che è nel segreto; e il Padre tuo, che vede nel segreto, ti ricompenserà.E quando digiunate, non diventate malinconici come gli ipòcriti, che assumono un'aria disfatta per far vedere agli altri che digiunano. In verità io vi dico: hanno già ricevuto la loro ricompensa. Invece, quando tu digiuni, profùmati la testa e làvati il volto, perché la gente non veda che tu digiuni, ma solo il Padre tuo, che è nel segreto; e il Padre tuo, che vede nel segreto, ti ricompenserà».

Welcome to the 12th episode of series two of ‘SCI Care: What really matters' and the third collaborative episode between the International Spinal Cord Society (ISCoS) and Wellspect®.In this podcast episode, we follow on from the recent webinar on the 'Importance of patient-centred care in neurogenic bladder and bowel management', continuing the discussion with a particular focus on clinical practice.Host Mr Grant Friedrich, Clinical Relations Manager for Wellspect Healthcare, is joined by Dr Ammirati, a medical doctor at the Complex Structure of Neuro-Urology of the Orthopedic Trauma Centre / Unipolar Spinal Unit of the "Città della Salute e della Scienza di Torino", and Veronika Geng, Head of the Advisory Centre for Nutrition and Digestion for Spinal Cord Injured People in Lobbach, Germany. The discussion focusses on the advantages of patient-centred care in neurogenic bladder and bowel management, the importance of adherence to bladder and bowel management, and possible ways to improve adherence to bladder and bowel management. The panellists agree that the practitioner's role in the patient's journey is to guide, educate, and negotiate with the patient, ensuring they are included in all steps along the way as they navigate how to live with a spinal cord injury. By keeping the patient part of their healthcare decision-making process, goals will be realistic and the person's individual and specific needs will be met.The Vision of ISCoS is to "facilitate healthy and inclusive lives for people with spinal cord injury or dysfunction globally". Partnership and collaboration are key in helping us to realise this vision.We are delighted that we have been able to partner with Wellspect on an inspiring and informative collection of webinars and podcasts.We hope you enjoy listening.If you have any questions or suggestions for future episodes or would like information on becoming an ISCoS member, please email admin@iscos.org.co.uk.  The 60th Anniversary Annual Scientific Meeting this September is available on-demand until January 2nd 2022, you can sign in or register here Work has begun for the 61st Annual Scientific Meeting 2022 you can register for updates here. This show is brought to you by ISCoS - you can follow us on Twitter @iscosmeetings, hosted by Prof Ruth Marshall produced and directed by Heather Pownall of Heather's Media Hub @heathershub*The opinions of our host and guests are their own.--- Send in a voice message: https://anchor.fm/scicare/message

The Big Themes:• Facebook is evil: It's a lot like going to work for Philip Morris 30 years ago. We should continue to invest in solving the world's problems.• Tesla is undervalued: Tesla is a software company. Tesla is an automaker – and in five years we'll see who's right.• An interesting and kind of fun way: How can you make these companies more software companies over the next few years?• The faster we can get there: When we're taking shots at social media – there's big problems that need to be addressed.The Big Quotes:“And frankly, every time I think, okay we've hit rock bottom. It's like they figured out a way to drill further into the rock and look worse.”“And so we need to be really careful that we don't I think that we don't paint with too broad a brush there.”“Do you work digital or not? It's just like, so are you going to work or you're going to retire?”This episode is brought to you by BMC Software.

The Big Themes:• Your data pipeline is key: A strong data pipeline with a decent model is better than an awesome model with a weak data pipeline• Sit down with the executives: It's relevant at the executive level as well. Guys at the CEO level like Cloud Wars All-Star Tony Uphoff are pushing the envelope through data.• In data analysis, there's a war for high quality talent: Figure out how to get better candidates into the top of your funnel and move the right candidates through that funnel faster.The Big Quote:“I think this concept of just digital twins in general is something that you're going to see start to radiate across more and more of complex systems.”This episode is brought to you by BMC Software.

There were hugs, smiles and a tight embrace at Toronto airport earlier this month as a 3-year-old Afghan boy reunited with his father.The boy, who was not named because he is a minor, was separated from his family on Aug. 26, when there was a suicide attack at the Kabul airport in Afghanistan.He was put on a plane out of the country and spent two weeks at an orphanage in Qatar, according to Qatari and Canadian media reports. Officials with the UN as well as the Qatari government helped reach his family in Canada, and he was able to reunite with them.Related: 'We are still here': Afghan UN employees worry about their safetyBut this boy is lucky.In the chaos of the US withdrawal from Afghanistan and the mass evacuation from Kabul, a number of unaccompanied minors ended up on flights out of the country. Now comes the difficult task of reuniting them with their families or, for those who don't have any relatives, helping them find new homes.Right now, there are at least 300 Afghan children who were separated from their families during the evacuation, according to Wendy Young, president of Kids in Need of Defense, an organization that provides support for unaccompanied minors.“We know of children whose parents were killed in the process, and we know of children who were separated and placed on a different flight than their parent or their guardian and the child is in one country and the parents in another.” Wendy Young, Kids in Need of Defense, president“We know of children whose parents were killed in the process, and we know of children who were separated and placed on a different flight than their parent or their guardian and the child is in one country and the parents in another,” she said.Related: Minerals, drugs and China: How the Taliban might finance their new Afghan governmentYoung said that has spurred a global effort to help reunite Afghan children separated from their parents and also find housing for unaccompanied minors — children who evacuated with a friend or relative and also some who are orphans. The US State Department and the Department of Health and Human Services didn't respond to questions from The World about which countries unaccompanied Afghan minors have been relocated to, but earlier this month, US Secretary of State Antony Blinken visited some of them at Ramstein Air Base in Germany.Some unaccompanied Afghan minors have started arriving in the US. This week, about 75 unaccompanied minors arrived in Chicago, according to city and federal officials, the Chicago Sun Times reported.Others are staying at the Fort Bliss military base in El Paso, Texas, where Barbara Ammirati, deputy director for child protection in emergencies with Save the Children, has been part of the team offering support.Ammirati said that when the children arrive and it is determined they are unaccompanied, they are immediately separated from the general population at the base and placed in shelters.“It's a very temporary accommodation,” she said. “It's a small home — one room — and we've set it up. ... it looks like a bedroom with a welcoming living space.”No more than two minors, she said, stay in these facilities at a time and most of the minors she has worked with are between 15 and 17.Ammirati said these Afghan kids have been through a traumatic experience, but they are ready to start their new lives in the US.Related: Afghan women sidelined under new Taliban rule: ‘This country places no value on me as a woman'“They are happy to be in the United States. The first questions are, ‘Can I go to school, if I go here, will I go to school?' A university student is desperate to get back to classes,” she said.Need for a more permanent statusYoung, from Kids in Need of Defense, said she is concerned about the children's immigration status because Afghan children fall into a unique category.“They've been evacuated but they haven't been processed and vetted as the rigorous and, frankly, bureaucratic and lengthy process that normally happens through refugee resettlement,” she said. “They haven't spontaneously arrived here, so this is why they're in parole status.” (An individual who is ineligible to enter the US as a refugee, immigrant or nonimmigrant may be "paroled" into the US by the Secretary of Homeland Security.)Related: The Taliban want international recognition. Countries are debating.That means they face a lot of uncertainty. Earlier this month, Young's organization published a set of guidelines to protect Afghan children arriving in the US.Meanwhile, people from Afghan communities in the US have been springing into action. For example, the Afghan American Foundation recently hosted a Zoom session to explain what becoming a foster parent entails.Nadia Hashimi, a pediatrician and writer, started off the conversation.“For these children, this may be an event in their lives that stays very fresh. I think trauma does that. Trauma has a very deep footprint on the soul and so the easier, and the more comforted we can have these children feel in this moment and this process, the better it is.”Nadia Hashimi, pediatrician and writer“For these children, this may be an event in their lives that stays very fresh,” she said. “I think trauma does that. Trauma has a very deep footprint on the soul and so the easier, and the more comforted we can have these children feel in this moment and this process, the better it is.”About 800 people across the country were on the call, Hashimi said.Unaccompanied children arriving in the US is nothing new.Young said in recent years, the official US response has been more about law enforcement than child protection. In the case of these Afghan children, she said, the approach is still a work in progress.“What I hope happens is that we'll look back at it and figure out what lessons learned there are because what we see whether you're looking at the Central American situation or the Afghan situation is that these kids need our help,” she said. “And we owe it to them to have a system in place that kicks in rapidly and ensures that they get everything that they need including family reunification where appropriate.”

The Big Themes:• You've got great leaders at the top of the house: In both those companies you really understand innovation.• One of our venture companies: We sold a company to a publicly traded company that when that transaction happened, I got a lot of congratulations.• That ship has sailed: I also think though that speaks to another thing that we expected to happen when you plug into an organization – like in this case of Salesforce or Oracle.• Very fast moving dynamic: So we need to keep in mind not to get locked into an idea that will surely be obsolete in a matter of weeks or months.The Big Quotes:“But that doesn't mean that the $27 billion was a fair price. I think it probably was not unfortunately for the shareholders.”“The game was how many times could you say synergy in a windowless conference room for 30 minutes?”“I think in enterprise tech you're really seeing something of this happening now in Slack.”This episode is brought to you by BMC Software.

The Big Themes:Taking a victory lap: When you look at those lists, these are technology companies that have figured out how to partner and work within the industry.New Carnegie Mellon masters program: I believe the first masters level joint business degree is to help students prepare to be a product manager.The enemy of my enemy is my friend: But the other part of that is true as well. There's a lot of moving pieces on the chess board right now.Rockefeller breaking up Standard Oil: After the breakup, he got significantly wealthier. Could the same happen with Amazon and AWS? The Big Quotes:“I think that the other thing that's going to be interesting as I kind of look into the back half of 2021 and 2022 is I do think we're going to start to actually see a lot more innovation around healthcare.” “The vaccine rollout is nothing short of a miracle.” This episode is brought to you by BMC Software. 

The Big Themes:Plotted on a bell curve: Some are amazing, and some are terrible – and some are in the middle.Stability is not the issue: There's capital behind these companies that give you the same amount of runway you could expect from any of the other kinds of companies.The term unicorn was coined: You needed to raise money at least a billion dollar valuation from one company in your portfolio to make that portfolio be a top performing venture portfolio.Microsoft and Nuance: You have the sales, the partnership, and the marketing muscle that a company like Microsoft can provide. The Big Quotes:“But the more interesting thing to me was that in the first five months of 2021, there were 187 companies that for the first time raised money at over a billion-dollar valuation.” “The thing that's more concerning to me is I think there's a lot of reflection we, as an industry, need to do on the right way to create healthy corporate governance among these companies.” “And I think it's time for CFOs to stop worrying about just doing the logistics.” This episode is brought to you by BMC Software.

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The Big Themes:We're getting back to normal – which is awesome: But the markets are crazy and the blank check companies – or SPAC as they're often called – are red hot.Private schools are expensive: Do you want to get that Gulfstream or not?These magical moments: A lot of these companies want to delight their customers. They absolutely do make these companies more efficient.There's a bigger mountain over there: We're looking over there and saying it's a ton of fun right now. The Big Quotes:“I think they will both be fabulously successful – great companies that are here to stay.” This episode is brought to you by BMC Software.

Luca Ammirati"L'inizio di ogni cosa"Sperling & Kupferhttps://www.sperling.it/Tommaso credeva di avere dei punti fermi nella vita: il tranquillo lavoro come professore di liceo; una compagna su cui contare, Irene; i suoi romanzi preferiti, di cui ama trascrivere gli incipit sulla Moleskine arancione che porta sempre con sé. Finché una sera, a una festa, la sospetta confidenza tra Irene e un nuovo collega e il logorante litigio che ne segue fanno vacillare ogni sua certezza. Così, quando la mattina dopo lei parte per un viaggio di lavoro, Tommaso rimane da solo a Sanremo, in preda ai dubbi sul loro rapporto, su se stesso e la sua vita.I giorni lontano da Irene gli serviranno a capire che non può controllare la tempesta che ha dentro, per superarla deve passarci in mezzo, sfidarla. Prima l'imbattersi in una serie di quadri raffiguranti un misterioso volto femminile, poi l'incontro con una donna del suo passato: la vita sembra prendersi gioco di lui, ma lo conduce in un posto magico sulle colline sanremesi, Bussana Vecchia, un paese semidistrutto da un terremoto e ripopolato da una comunità di artisti.Quel luogo sulle colline, che è stato capace di andare oltre la fine, insegnerà a Tommaso che solo accettando il nostro passato possiamo camminare verso il futuro: come dopo un terremoto, quando qualcosa finisce, è lì che tutto comincia, che è il momento di scrivere un nuovo inizio.Luca Ammirati (Sanremo, 1983) è responsabile interno della sala stampa del Teatro Ariston, dove ogni anno si svolge il Festival della canzone italiana. Ha fatto il suo esordio nella narrativa con Se i pesci guardassero le stelle, tradotto e pubblicato anche in Germania e Austria, presentato in giro per l'Italia riscuotendo il consenso dei lettori e dei librai.IL POSTO DELLE PAROLEascoltare fa pensarehttps://ilpostodelleparole.it/

Ai microfoni delle nostre Donne al Volante, ossia Lilly & Katia, nel pomeriggio del 2 marzo, è stato ospite Luca Ammirati, autore del libro L'inizio di ogni cosa. Direttamente da Sanremo, in veste di responsabile interno della sala stampa del teatro Ariston, ci ha parlato dell'atmosfera strana presente in città, poiché questi giorni dell'anno, solitamente, non sono caratterizzati dalla tranquillità ma, nonostante ciò, si percepisce un piccolo segno di emozione. Inoltre, ci ha spiegato come sia difficile vedere in giro gli artisti date le misure anti COVID che loro e i lavoratori devono seguire.

The Big Themes:No more looking in the rearview mirror: We're talking about what we can do looking out at the front of the car, and how we can steer the car going forward.The CIO's next adventure: You've done all the hard work to get yourself to a point where you can help these companies do this.Truly transformational business functions: We're going through a transformation right now where we shift information from something that is relegated to the back office, to something that changes how each of these business functions work.How do we maximize revenue? How do we optimize lifetime value? And the reality is you've got to apply industry insights on top of that. The Big Quotes:“Be the person who's going to the board and wowing them with how this can transform your business.” This episode is brought to you by BMC Software. 

Liliana Russo in TuttoLibri presenta... L'inizio di ogni cosa, di Luca Ammirati

The Big Themes:Andy Jassy is now the CEO of Amazon: The force of nature that is Jeff Bezos is going to be executive chairman.Databricks and Snowflake are going neck-and-neck: Databricks closed a billion dollars of funding at a $28 billion valuation. That makes Snowflake look cheap!Oracle started the world's greatest relational database: Oracle has spun out vertical solutions that can deliver impressive business value.Building a data lake or building a data swamp: The customers want to start getting business value from it, whatever it is. The Big Quotes:“The value proposition of the C-suite is we can take that data and change how your business runs to make it better, faster, and allow you to delight customers in new ways.” This episode is brought to by BMC Software.

The Big Themes: Wall Street/Main Street: The software sector had a great year. The markets didn't correct. Main Street not so much – stores are boarded up and it's a ghost town. Disney played this perfectly: Netflix and Disney are going head-to-head. Both companies have done well in 2020, but you're going to see Disney outperform Netflix in 2021. Walmart and Amazon: Does Walmart really want to finance their number one competitor – and does Amazon want that too? Rockefeller, Standard Oil, and AWS: John D. Rockefeller fought hard not to have Standard Oil split apart, but the wealth creation that happened was huge. The Big Quotes: “I still think Amazon needs to spin out AWS. It's crazy that they haven't yet.” This episode is brought to you BMC Software.

The Big Themes:Apple and a thousand Intel employees: The M1 chipset Apple wanted was a billion-dollar investment in 5G, which they did in 2019. Will Apple use M1 to go up against AWS?The 800-pound gorilla: Microsoft has a culture that looks less transactional and more collaborative. They are a Trojan Horse – and an 800-pound gorilla.Oracle and SAP are back at it again: They're both creating elegant and powerful new apps for industry-specific solutions in what promises to be a huge new market.Transform the industry: How we can be business partners to transform healthcare, manufacturing, automotive, and mobility – and how to adjust those businesses over the next 12 to 18 months.The Big Quotes:“I literally can't come up with anybody other than potentially Jeff Bezos, who just wants to be CEO of this whole thing, who this isn't a win for spinning out AWS at this point.”This episode is brought to you by BMC Software. 

The Big Themes:ServiceNow vs. IBM: The market cap of ServiceNow, with $4 billion in revenue, is closing in on that of IBM, which is a 115-year-old company with $75 billion in revenue! Meanwhile, Bill ServiceNow CEO Bill McDermott teams up with IBM to unleash AI on IT. Go figure!The markets continue to go up: The economy at large is finding its sea legs – but it's always about the future.Let's figure out what customers want: Customers want solutions and they want solutions for the businesses that they're in, and the industries that they operate in.Not the dream job it once was: Young people feel that working at Facebook today is about as appealing at working for a tobacco company. For top students at Carnegie Mellon, the dream job is with Elon Musk's SpaceX. The Big Quotes:“It's impossible to imagine a CEO on the golf course at Augusta saying, ‘I really need to fix my cloud infrastructure, but I don't really care as much about my ERP solution.' That's just not how they think!” This episode is brought to you by BMC Software. 

The financial sector has been the frontlines of biometric and ID verification evolution for nearly a decade. And that's why, on this episode of ID Talk, we are pleased to present podcast host Peter Counter conversation with Thomas Ammirati, CRO of Onfido. Onfido is one of the leading pioneers in digital onboarding, and in this interview Ammirati reflects on his company's pioneering activities in the financial sector, and how that success can be repeated in other verticals like healthcare and enterprise. It's a fascinating conversation that touches on everything from face biometrics to fighting account takeover fraud, and it gives a full picture of one of the most active and exciting spaces in biometrics and identity. To learn more about the topics we discussed in this episode visit https://onfido.com/

 Dans cet épisode, je reçois une femme exceptionnelle avec un parcours incroyable. Valérie Ammirati n'est pas une experte comptable comme les autres. Également présidente d'Initiative Nice Côte d'azur, Valérie nous partage son parcours en tant femme passionnée avec une vision très claire. Des conseils concrets sur comment suivre son entreprise, comment la gérer au quotidien et apprendre de ses erreurs.    Retrouver Valérie : Son site Facebook Twitter Linkedin Son livre :  E-myth : le mythe de l'entrepreneur revisité : Pourquoi la plupart des petites entreprises échouent et que faire pour réussir  Un épisode motivant. Si vous avez aimé cet épisode, n'hésitez pas à laisser une note et un commentaire sur iTunes, Apple podcast ou votre plateforme d'écoute ! Cela aide à nous faire connaître ( et aide d'autres entrepreneuses )

The Big Themes:• The power of the network effect: Will it trigger next wave of M&A for software companies?• A crisis is a terrible thing to waste: This crisis has been a great accelerant – and now the question is can you take advantage of that accelerant.• Tech addiction: What's happening across society right now is around tech addiction. There is a right way and there is a wrong way – which do you choose?• Pets.com was way too early: The Super Bowl commercial in 2001 was the demise of pets.com. Actually, the idea was perfect—but the timing was brutally wrong. There's a big lesson in that for all of us today.The Big Quotes:“Three cell phones that can't talk to each other don't really have any value by themselves. It's the ties between the three that become valuable.”This episode is brought to you by BMC Software

The Big Themes: • Six months ago, would anyone on the planet believe that 20% of incoming Harvard freshmen would defer? Great example of the crazy times we’re in! • Sean’s message to those and other would-be college freshmen choosing to take a gap year: “Why don’t you spend that time starting your own business?” The course and content Sean’s developing for that are drawing a great deal of interest. • Disney purchasing TikTok makes a lot of sense – even Twitter purchasing TikTok makes a lot of sense. But Oracle or Microsoft? Crazy! • Ten years ago, when Oracle founder Larry Ellison bought Sun Microsystems, some people thought it was a brilliant move, but many that it was insane. But TikTok is the next level of crazy! The Big Quote: “TikTok is an incredibly popular social media platform, especially for the very young demographic.” This episode is brought to you by BMC Software

Each month, “Ammirati on Innovation” episodes will look at ways that the disruptive-startup mentality is spreading beyond young entrepreneurs to big established corporations. Serial entrepreneur, venture capitalist and Carnegie Mellon B-school professor Sean Ammirati, who sits at the intersection of these high-change dynamics, provides insight. In this podcast, Sean and I talk about how long it will take until we get the economy back up and moving again.Episode 14Reimagining our companies is on Sean’s mind. We need to figure out what the right innovation strategy is. The world is going to be very different, and you need to build new products, new services, and new value to your customers. And companies need to do all that more rapidly and with more commitment than ever before.The notions of courage, commitment and vision in the face of daunting threats have been with us forever. I mention to Sean one of my favorite poems: “Horatius at the Bridge” by Thomas Babington Macaulay describes how Horatius steps forward to do what others believe is impossible as the Etruscan army is about to invade. The specific form of the challenges faced by people change over time, but the need for powerful and fearless leadership is a constant.Sean concludes with revisiting your operational plan, and how you’re investing in your assets this year. In this time of crazy transition and transformation, that’s all we have.Also in this episode:· Steve Jobs and Corning Gorilla Glass· Work from home forever!· A magical time for your business· The mirror is much closer than it appears See acast.com/privacy for privacy and opt-out information.

Each month, “Ammirati on Innovation” episodes will look at ways that the disruptive-startup mentality is spreading beyond young entrepreneurs to big established corporations. Serial entrepreneur, venture capitalist and Carnegie Mellon B-school professor Sean Ammirati, who sits at the intersection of these high-change dynamics, provides insight. In this episode, Sean and I talk about business model transformation and how Microsoft and FedEx are reimagining the world.Episode 13Sean talks about how we’ve gotten to a point where companies have made 80% of the investment they needed to in digital transformation (but he thinks they’ve gotten about 20% of the value from that investment). Business model transformation is not just making experiences more efficient and making your supply chain run a little smoother, but actually completely turning your businesses into digital-first models.Taking a turn, Microsoft and FedEx are partnering to combine the scale of the global digital logistics network of FedEx with the power of Microsoft’s intelligent cloud. Businesses will have an unprecedented level of control into the global movement of goods.Concluding, Sean says that we need to start looking at how do we take this situation that we're all in and use it to make our companies better, stronger, and more vibrant. We owe it to our employees, we owe it to our customers, and we owe it to our shareholders.Also in this episode:· The hen and the pig – no such thing as a merger of equals· Joint AI innovation between Microsoft and Novartis· Workday and Salesforce: Perfect together· Is it a V-shaped recession, or a U-shaped recession? See acast.com/privacy for privacy and opt-out information.

Cardiovascular experts, Drs. JoAnn Lindenfeld, Javid Moslehi and Richa Gupta from Vanderbilt University Medical Center and Dr. Enrico Ammirati from Milan, Italy join Amit and Dan for a two part discussion about all things to consider for myocarditis in general (part 1) and COVID-19 myocarditis and heart transplantation in the COVID-19 era (part 2). Flutter Moment by Barrie Stanton (RN). On the CardioNerds Myocarditis page you will find podcast episodes, infographic, youtube videos, references, tweetorials and guest experts & contributors, flutter stars and so much more. Take me to the Myocarditis Series Page  Take me to the COVID-19 Series Page Take me to the Episode Topics Page Dr. JoAnn Lindenfeld, is a Professor of Medicine and the Director of Heart Failure and Heart Transplantation Section at Vanderbilt Heart and Vascular Institute.  She is the past president of the Heart Failure Society of America and serves on editorial boards of numerous journals including JACC, JACC Heart Failure and JHLT.  She is also a member of the AHA/ACC/HFSA heart failure guideline writing committee and was previously chair of the HFSA practice guidelines for the 2006 and 2010 guidelines. In addition to this she’s been an investigator in multiple large-scale clinical trials including the COAPT trial and has served on numerous steering committees, end point committees and data and safety monitoring committees. She is the author of a more than 300 original papers, reviews, and book chapters in the field of heart failure and heart transplantation. Dr. Javid Moslehi is an associate professor of medicine at Vanderbilt University Medical Center where he is the director of the cardio-oncology program.  He is a clinical cardiologist and basic/translational biologist interested in cardiovascular complications associated with novel molecular targeted cancer therapies and the implications of these on our knowledge of basic cardiovascular biology. At Vanderbilt he runs an independent basic and translational research laboratory and program with a focus on signal transduction in the myocardium and vasculature as well as establishing pre-clinical models of cardiotoxicity involving novel targeted oncologic therapies. Dr. Enrico Ammirati is an assistant professor of cardiology and advanced heart failure and transplant cardiologist in Milan, Italy at the Niguarda Hospital with a special research interest and expertise in acute myocarditis and acute heart failure.  He is a fellow of the European Society of Cardiology and has won numerous awards, he has also published incredibly important work on the distinction between fulminant and nonfulminant myocarditis and the prognostic implication of histologic subtypes.  His research interests also include the role of adaptive immunity in heart transplantation and atherosclerosis and he is the author of well over 100+ peer reviewed publications.

Each month, “Ammirati on Innovation” episodes will look at ways that the disruptive-startup mentality is spreading beyond young entrepreneurs to big established corporations. Serial entrepreneur, venture capitalist and Carnegie Mellon B-school professor Sean Ammirati, who sits at the intersection of these high-change dynamics, provides insight.Episode 12In this episode: Sean says founders are some of the most creative and innovative people. They have a combination of intellectual courage that makes them pretty remarkable. He says Larry Ellison of Oracle, Larry Page and Sergey Brin of Google, and Mark Zuckerberg are the Mellons and Carnegies of this generation. Sean says a crisis is a terrible thing to waste. He says he’s seeing it across his companies. These are businesses that he has investments in and it’s created real tailwinds. Sean says Disney+ had a great quarter – and now they are catching up to Netflix. But Disney’s core theme parks are another issue. Sean says airline companies have taken all of their profits and plowed them into stock buybacks. He says that puts them in a very weak position. Sean thinks that transportation is less important than it was before – and we’ll figure out a way to do it remotely. He says SurfAir is a great example. They flew from regional airports, and he had a number of colleagues who were just fanatics about the SurfAir experience. But, he says, are we going to travel on airplanes are some point? He suspects they will. See acast.com/privacy for privacy and opt-out information.

Cardiovascular experts, Drs. JoAnn Lindenfeld, Javid Moslehi and Richa Gupta from Vanderbilt University Medical Center and Dr. Enrico Ammirati from Milan, Italy join Amit and Dan for a two part discussion about all things to consider for myocarditis in general (part 1) and COVID-19 myocarditis and heart transplantation in the COVID-19 era (part 2). Flutter Moment/Song by Drs. Matt (Internal Medicine) and Beth Faiman (Oncology). On the CardioNerds Myocarditis page you will find podcast episodes, infographic, youtube videos, references, tweetorials and guest experts & contributors, flutter stars and so much more. Take me to the Myocarditis Series Page  Take me to the COVID-19 Series Page Take me to the Episode Topics Page Show notes prepared by Dr. Richa Gupta What is myocarditis? An inflammatory disease of the myocardium, classically as demonstrated on biopsy or autopsy specimen. How do we classify it? 4 ways: prognosis, time, etiology and histology. Prognosis: uncomplicated (no HF or ventricular arrhythmia, LVEF > 50) vs. complicated (fulminant with hemodynamic or electrical instability, HFrEF) Time: acute (no prior HF or cardiomyopathy, all symptoms w/in last month) versus chronic inflammatory myocarditis Etiology: viral-induced, autoimmune disorders, drugs (i.e. immune checkpoint inhibitors), allergic forms Histology based on biopsy and the inflammatory milieu: giant cell (worst prognosis), eosinophilic, lymphocytic (viral or immune checkpoint) or granulomatous (sarcoid) How do we diagnose myocarditis? Biopsy = Dallas criteria require inflammatory infiltrate and myocardial necrosis, updated with certain immunohistochemistry criteria. The syndrome = chest pain, new HF, dyspnea, fatigue, palpitations, heart block or unexplained cardiogenic shock. All pretty nonspecific. What if you don't have biopsy? Use supporting criteria: = Abnormal EKG, arrhythmia, Tn elevation, wall motion abnormality on TTE, tissue characterization on CMR (T2 weighting for edema or LGE). Bottom line = use a MULTIPRONGED approach: syndrome + supporting criteria, rather than relying on only pathology or one technique. Why don’t we biopsy everyone? We only biopsy when it changes management. Inflammatory cell milieu on biopsy many not be specific enough to guide therapy. Yield can be low, not sensitive (especially if uncomplicated presentation), only getting a piece of the RV. There are risks (tricuspid valve trauma, RV perforationàtamponade). When do we think biopsy may change management? → When we find a treatable form in fulminant myocarditis: specific subtypes like giant cell or eosinophilic that are TREATABLE. → When it informs prognosis and tells us the patient is unlikely to recover: for example, giant cell carries BAD prognosis (> 60% will die or need transplant at 60 days) BUT—giant cell and eosinophilic will only comprise ~ 10% of all fulminant myocarditis—the rest may be all lymphocytic myocarditis (LM) for which there is no strong evidence for therapy! Many experts still use histology here to decide whether to immunosuppress based on cell milieu. We still need updated clinical trials to know if steroids are useful in fulminant LM. Do we really understand the mechanism of myocardial injury in what we call myocarditis? Not really. In the classic sense of the definition of myocarditis there is infiltration of the myocyte with immune cells resulting in myocyte death. However, there can also be direct cardiotoxicity as seen in injury caused by CAR-T cells accompanied by cytokine release syndrome and it is UNCLEAR if this is truly a myocarditis. How do we figure mechanisms out and why is this important? Only direct studies of the tissue can characterize these mechanisms of inflammation. This is hugely important because ultimately knowledge of what happens at the molecular level will inform the best therapeutic targets and dictate therapy. Dr. JoAnn Lindenfeld,

Each month, “Ammirati on Innovation” episodes will look at ways that the disruptive-startup mentality is spreading beyond young entrepreneurs to big established corporations. Serial entrepreneur, venture capitalist and Carnegie Mellon B-school professor Sean Ammirati, who sits at the intersection of these high-change dynamics, provides insight.Episode 11In this episode, Sean says he hasn’t been on a plane for almost four weeks – and that’s unusual because he is always on a plane to somewhere. So he has been able to have dinner with his wife and kids, and it’s been incredible. He says it puts life in perspective, and that’s the most important thing.Sean says that his roughly 30 companies are negatively impacted by COVID-19 – but he says that’s secondary to health and safety. He says everyone is working from home. Sean says he authored a book called “The Science of Growth,” where he looked at pairs of companies and asked, why did one company take off and the other one didn’t. Why is a third of the internet running on top of WordPress? Why are people driving Teslas and not Fiskars? Why do people have a Facebook account and not a Friendster account? Sean says he wouldn’t want to be in the hospitality business today – or the travel business. He quotes Warren Buffett as saying, “Only when the tide goes out do you discover who’s been swimming naked.” Sean says he typically uses that in board meetings when it feels like companies are swimming to close to the knife’s edge. He says it’s true of a global company, and it’s also true inside a 10 person company. He says he’s pretty proud that his portfolio companies are doing a pretty good job of making sure that they’re doing the right thing. Sean says what some companies are doing over the last five years in terms of share buybacks to inflate their stock. He says there are companies who had really good offers to raise money three months ago and held out to try to get a 5% higher valuation. See acast.com/privacy for privacy and opt-out information.

Each month, “Ammirati on Innovation” episodes will look at ways that the disruptive-startup mentality is spreading beyond young entrepreneurs to big established corporations. Serial entrepreneur, venture capitalist and Carnegie Mellon B-school professor Sean Ammirati, who sits at the intersection of these high-change dynamics, provides insight.Episode 10In this episode, Sean says Andy Jassy has been an incredible CEO of AWS. He says AWS would be one of the 10 most valuable companies in the world the day it went public. And he understands that it basically works for everybody in the world – except for Jeff Bezos. He says there are a ton of customers making very different decisions if AWS was a standalone entity. But, he says, will the CEO of Kroger compete with Whole Foods? He doesn’t think so.Sean says Microsoft and Google are doing in the cloud space exactly what retailers, healthcare companies, and banks, etc. They’re saying, “What’s our incumbency advantage, and what are we best in the world at?”I tell him that Peter Steube, one of our latest Digital All-Stars, has a 10-year trendable data from CIOs and CTOs about the enterprise purchases they’re making. Peter says there is absolutely no question that in the last six months Google Cloud has gone up dramatically – and also Microsoft. Sean says it’s hard to uncouple Google Cloud from the rest of the Google digital advertising business.Sean says AWS needs to be set free. He says that’s a prediction he’s feeling much better about here in February than he was when he made it in January. See acast.com/privacy for privacy and opt-out information.

Each month, “Ammirati on Innovation” episodes will look at ways that the disruptive-startup mentality is spreading beyond young entrepreneurs to big established corporations. Serial entrepreneur, venture capitalist and Carnegie Mellon B-school professor Sean Ammirati, who sits at the intersection of these high-change dynamics, provides insight.Episode 9In this episode, Sean and I discuss Slack. He says Slack has basically been slashed in half – $42 a share vs. $22 a share. Its market cap is $12 billion. Sean says what would these statistics be worth inside Oracle, Salesforce, Microsoft, or Google. He says that with some of the assets Microsoft has, LinkedIn plus Slack would be a very good combination. Sean says LinkedIn bought Lynda, a corporate education company, for $1.5 billion, but so far it’s been an accretive acquisition.He speculates Walmart has the potential to buy one or two very large companies – including FedEx, which he says would be a good acquisition – and maybe Shopify too. He says we’ll see a further investment in Walmart Labs, including new business models.He then turns to Amazon and AWS. He says he just can’t wrap his head around why Amazon won’t spin out AWS this year. He says he’s seen all the denials from the management team – but it just doesn’t make sense that they don’t want to do this. Sean says how does Walmart feel about cutting checks to AWS? I say that AWS will finish the calendar year with about $38 billion in revenue – placing them among the top seven tech companies.Sean says he’s not an economist, but his conclusion is that often companies are wrong. They often deliver with confidence and that confidence often turns out to be incorrect. The market almost certainly needs to correct in 2020.Sean’s podcast is Agile Giants, and it’s on all the major platforms. See acast.com/privacy for privacy and opt-out information.

Each month, “Ammirati on Innovation” episodes will look at ways that the disruptive-startup mentality is spreading beyond young entrepreneurs to big established corporations. Serial entrepreneur, venture capitalist and Carnegie Mellon B-school professor Sean Ammirati, who sits at the intersection of these high-change dynamics, provides insight.Episode 8In this episode, Sean and I discuss how Disney+ had over 10 million people signed up in 24 hours – and they’re registering 1.2 million downloads a day on the app. He says his wife was one of the 10 million people who signed up for Disney+. And because he has two kids he says you need food, water, and Mickey Mouse.I told him about a guy who used to work for Oracle who said to Larry Ellison, “Hey Larry, we’re doing a lot of stuff here at Yahoo and we got a call from some people at Disney. And they asked if maybe we could discuss the opportunity of doing some things together. I don't know, what should we tell them?” Larry said, “Let’s see, they have the greatest movies in the world, they have theme parks, hundreds of millions of fans around the world, an incredible brand, loyal employees. You know, all these assets you’d die for. What does Yahoo have? Free news and email.”Sean says SAP is reimagining HR the transition from HCM to HXM – in other words, employees first. He says SAP is creating a whole new category, and he thinks that’s not going to be the last thing you’re going to see coming out of SAP.Salesforce and Microsoft were in a bidding war for LinkedIn, and Sean says what felt expensive for LinkedIn now feels awfully cheap with the HCM space heating up.Sean circles back to Disney+ and says the CEO of Netflix should figure out what to do to level the playing field. He says that his currency is down in the last six months, and he has less currency to deals than he did six months ago. Sean knows the history of AOL and TimeWarner. He says the world has changed and you need to scale to play in the game that Netflix and Disney+ a playing out today.The Agile Giants podcast is on all the major platforms. See acast.com/privacy for privacy and opt-out information.

Each month, “Ammirati on Innovation” episodes will look at ways that the disruptive-startup mentality is spreading beyond young entrepreneurs to big established corporations. Serial entrepreneur, venture capitalist and Carnegie Mellon B-school professor Sean Ammirati, who sits at the intersection of these high-change dynamics, provides insight.Episode 7In this episode, Sean and I kick off with a new look at the evolving WeWork and Softbank story. Sean explores what it means that SoftBank chose to invest even more money into WeWork, and now owns about 80% of the business. Plus, the fact that the former CEO is making $180 MILLION during the transition! I think we all can agree, that’s a pretty good consulting package.In our last podcast episode, Sean compared WeWork to a real estate business. Now he says it’s basically a rental car company: they buy expensive fixed assets, and then they rent them out in very short units of time. But there are still reasons for optimism. For example, Sean says, Amazon has 5,000 WeWork desks in New York alone.We also debate whether the SoftBank decision to keep WeWork running is a smart one. Are they following the sunk cost fallacy? Or doubling-down on their belief in WeWork’s ability to lead the transformation of work trend? Sean quotes hedge fund manager Howard Marks, who says, “To be a great investor you need to be two things: you need to be contrarian and correct.” SoftBank is definitely being contrarian. Only time will tell if they’re also correct.Sean and I then jump to a discussion of a few of the Cloud Wars Top 10 vendors. I have some questions for Sean about ServiceNow, which now has Bill McDermott as CEO. You could argue that it’s the #1 most innovative company in the world; it’s growing at 35% and approaching a billion dollars in revenue per quarter.Finally, we have a high-level discussion of innovation. Sean says his employer, Carnegie Mellon, has been ten years ahead of the world in AI – they were using self-driving cars in the aughts. Innovation works differently everywhere. But some recent moves by Microsoft, Amazon and Google to take a leadership position in AI indicate that the time for widespread, non-stop innovation is NOW. See acast.com/privacy for privacy and opt-out information.

Each month, “Ammirati on Innovation” episodes will look at ways that the disruptive-startup mentality is spreading beyond young entrepreneurs to big established corporations. Serial entrepreneur, venture capitalist and Carnegie Mellon B-school professor Sean Ammirati, who sits at the intersection of these high-change dynamics, provides insight.Episode 6In this episode, Sean and I discuss the pain and suffering at WeWork, which had roughly a $50 billion market cap, and is now struggling to do one-third that much. Their CEO, Adam Neumann voted to oust himself amid various scandals, and their “community adjusted EBITDA” he calls a made-up metric.SoftBank, their largest investor, was poised to push for an IPO, but Sean says WeWork was a $10 billion great idea – not a $50 billion great idea. He says this was always, at the end of the day, a real estate business, and he compares it to CB Richard Ellis – although with a 5x valuation. And Sean says it turns out that beer and kombucha on tap is expensive – and there’s a lot of that in WeWork spaces.I tell him about my experience eating seal meat with SoftBank. Sean says I should have moved it around on the plate and hope something else comes along. See acast.com/privacy for privacy and opt-out information.

Each month, “Ammirati on Innovation” episodes will look at ways that the disruptive-startup mentality is spreading beyond young entrepreneurs to big established corporations. Serial entrepreneur, venture capitalist and Carnegie Mellon B-school professor Sean Ammirati, who sits at the intersection of these high-change dynamics, provides insight.Episode 5In this episode, Sean and I discuss how he wants everybody to think about themselves as an entrepreneur – and that includes people working inside large businesses. He quotes Jim Collins of “Good to Great” fame by saying good is the enemy of great – and that’s why some entities don’t become great. Sean says that software, when done well, provides asymmetric value, and how Satya Nadella of Microsoft said that over the next five years, 500 million new applications will be written – far more than in the history of the software industry. And finally, Sean says you can go to corporatestartuplab.com and see free tools that are in development – all the Corporate Startup Lab asks for is feedback. His podcast Agile Giants is on all the major streaming networks. See acast.com/privacy for privacy and opt-out information.

D and L Coffee Service Inc. presents the #1 listed “Food Radio show Philadelphia”, Small Bites with Donato Marino and Derek Timm of Bluejeanfood.com on Wildfire Radio Podcast Recording Studio this Sunday, August 11th at 635pm EST with a stellar lineup with special guest co-host Chef Michael Dangelo of Ocean Casino • Resort. Chef Michael is an experienced pastry chef with a demonstrated history of working in the food and beverages industry with a Culinary Certification focused in Culinary Arts/Chef Training from Academy of Culinary Art, Atlantic Cape Community College. Chef Michael is also the Chef Coordinator at The Salvation Army USA where he works on special dinners to raise funds to feed those in need with a group of Volunteer Chefs to prepare Thanksgiving and Christmas dinner for Thousands of needy family's every year. We are thrilled to welcome Micheal Sparks the CEO AND CO-OWNER of UGK bringing one of the hottest culinary events to Philadelphia on Saturday, August 17th called The Underground Kitchen “The New Americana” Tour with Homer Laughlin China Collectors Association - HLCCA. This experiential dining society, is known for hosting high-style, multi-course dinners in secret locations with renowned and up-and-coming chefs. The tour, inspired by Netflix's "Chef's Table," will tell the diverse American stories of our chefs through their dishes, each carefully selected to convey personally memorable moments from their life. The featured chef in Philadelphia is Michael Stuckey of Southern Way Catering, the premiere catering company of Columbia, South Carolina. “Part of Underground Kitchen is us getting to know our chefs personally – getting to know their hearts and souls and not just their heads and hands,” adds Sparks. “This tour is about our chefs telling their unique personal stories – from childhood to adulthood… sometimes tragic, more times triumphant – all prepared and plated in an intimate, evocative, community-connecting, no-holds-barred multi-course dinner.” Sounds like a great time to us! Without Derek Timm in studio, the Small Bites crew were in a pickle so they decided to call upon Lee Lawley the owner of Delco Dills to help out and come in. Delco Dills – In a Pickle? Get it? Oh, nevermind. Delco Dills LLC is a small, family-owned pickle business operating in Collingdale, Delaware County PA. After much experimentation, a perfect combination of brine and ingredients produced a fresh and flavorful pickle that Lee along with his wife Elaine Lawley began to share with family and friends. An overwhelming and humbling response of positive feedback and support inspired them to continue in their pickle-making efforts and share the product with others. They began selling their product at local fairs and festivals and now can be found in local markets, pizza places, and restaurants in Delaware and Chester counties as well as a farmer's market in New Jersey. Then also joining in the fun will be Mike Ammirati of Ammirati Coffee who is based in New York and Enrico Marchionni who is the east coast sales manager for Toschi Vignola. Ammirati Coffee is a 56 year old family owned coffee importing & distribution company in the NYC area supplying the foodservice industry with some of the finest Italian products on the market today and they have partnered with Toschi Vignola. Toschi Vignola is a 75 year old family owned Italian company located just outside of Modena, Italy and Toschi specializes in flavored syrups, ingredients for gelato, sorbets, & confectionary, along with the world famous Amarena cherry to name just a few. Ammirati is proud to announce that they are the first company in the United States to import & distribute Toschi to the foodservice industry. Mike Ammirati & Enrico Marchionni are working effortlessly to grow Toschi in all key cities around the country by offering a straightforward key approach network of distribution by offering full support. Give them try! Last, but certainly not least is Chris Parsons of Waffles4Tourette's and Hobbs Coffee. Their product is the Liège sugar waffle which is popular in the streets of Brussels. They have been making the waffles at Hobb's Coffee for the past five years as well as at the Swarthmore Farmers Market. Chris along with Marc Schmidt a neuroscience teacher and researcher at the University of Pennsylvania who founded Waffles for Tourette's with an aim to produce these delicious treats from Belgium while also raising awareness for Tourette's syndrome (TS), a fairly common tic disorder that is often misunderstood. A large percentage of their proceeds go to the national and local chapters of Tourette Association of America and they have donated over $11,000 since 2013. Something that tastes great with an even greater cause for good! You say you STILL NEED MORE!!! Don't forget we still have our regular weekly segments from Courier-Post nightlife correspondent and The The New York Times recognized for Blog Eating in SJ, John Howard-Fusco for his news of the week and please remember that John's book “A Culinary History of Cape May: Salt Oysters, Beach Plums & Cabernet Franc” from Arcadia Publishing The History Press is available, Chef Barbie Marshall who is a Chef Gordon Ramsay Hell's Kitchen Season 10 finalist, appeared on Season 17 of FOX Hell's Kitchen #AllStars, as well named Pennsylvania's most influential chef by Cooking Light will delight us with her tip of the week, and a joke of the week from legendary joke teller Jackie Martling of The Howard Stern Show fame and his autobiography “The Joke Man: Bow to Stern” from Post Hill Press is available for purchase on Amazon.com. D & L Coffee Services Inc. and Bluejeanfood.com hope you will use the TuneIn app to listen worldwide or also catch Small Bites Radio syndicated on KGTK 920AM, KITZ 1400AM, KSBN 1230AM, KBNP 1410AM, Salem Radio Network, ScyNet Radio, Stitcher Radio, PodOmatic, Indie Philly Radio, Player FM, iTunes, and TryThisDish Radio which is the only independently owned and operated international chef-driven foodie and lifestyle radio network in the world. https://small-bites.simplecast.com/ D & L Coffee Services has an expert staff of highly qualified, certified, and experienced office, technical, and sales personnel. D & L Coffee Services are able to provide your business, home, or special event the absolute best from the beans they sell, vendors they work with, Italian delicacies available for delivery, catering on-site for any sized affair, hands-on barista training, equipment available for purchase, and maintenance/repair services for your espresso and coffee machines. You can stop by their warehouse at 7000 HOLSTEIN AVE, SUITE 3, Philadelphia, PA 19153 during business hours or call Donato Marino the office at 215-365-5521 for an appointment, consultation, or any questions.

Each month, “Ammirati on Innovation” episodes will look at ways that the disruptive-startup mentality is spreading beyond young entrepreneurs to big established corporations. Serial entrepreneur, venture capitalist and Carnegie Mellon B-school professor Sean Ammirati, who sits at the intersection of these high-change dynamics, provides insight.Episode 4In this episode, Sean and I discuss how Microsoft and OpenAI announced a joint initiative, which they call AGI, and how $1 billion – no matter how big the company is – is a big investment. I quote from Sam Altman, Chairman and former CEO of YCombinator and now CEO of OpenAI, “The creation of AGI will be the most important technological development in human history with the potential to shape the trajectory of humanity.” Sean says Sam is not someone you would bet against, because it is the best-run tech accelerator out there. He then returns to how Bing feels like the old Microsoft, not the new Microsoft. Sean then notes that with challenge comes great opportunity, and people have some really exciting opportunities in front of them. See acast.com/privacy for privacy and opt-out information.

Each month, “Ammirati on Innovation” episodes will look at ways that the disruptive-startup mentality is spreading beyond young entrepreneurs to big established corporations. Serial entrepreneur, venture capitalist and Carnegie Mellon B-school professor Sean Ammirati, who sits at the intersection of these high-change dynamics, provides insight.Episode 3In this episode, Sean and I talk about decision-making, from a couple of angles. First, we explore the choice that giant global corporations have to make when a new opportunity comes along. Namely, do we do this ourselves, or partner up to make it happen? We also affirm that companies can walk and chew gum at the same time— meaning that they need to care about customers AND users at the same time. Sean has a podcast called “Agile Giants,” where he interviews guests ranging from CEOs, CTOs, and VCs to authors. With that unique POV underpinning his thoughts on the subject, Sean tells us that Oracle and Microsoft teaming up together makes for strange bedfellows. Later, Sean reveals that knew he wanted to be a programmer from the age of seven (!!!). See acast.com/privacy for privacy and opt-out information.

Each month, “Ammirati on Innovation” episodes will look at ways that the disruptive-startup mentality is spreading beyond young entrepreneurs to big established corporations. Serial entrepreneur, venture capitalist and Carnegie Mellon B-school professor Sean Ammirati, who sits at the intersection of these high-change dynamics, provides insight.Episode 3In this episode, Sean and I talk about how you can walk and chew gum at the same time – meaning that you need to care about your customers AND your users. Sean has a podcast called “Agile Giants,” where he interviews guests ranging from CEOs, CTOs, and VCs to authors. He speaks about how Oracle and Microsoft teaming up together makes for some pretty strange bedfellows. Later, Sean reveals that knew he wanted to be a programmer from the age of seven (?). See acast.com/privacy for privacy and opt-out information.

Each month, “Ammirati on Innovation” episodes will look at ways that the disruptive-startup mentality is spreading beyond young entrepreneurs to big established corporations. Serial entrepreneur, venture capitalist and Carnegie Mellon B-school professor Sean Ammirati, who sits at the intersection of these high-change dynamics, provides insight.Episode 2In this episode, Sean and I celebrate big, legacy businesses taking innovation “moonshots.” What about the Disney+ strategy makes it a Netflix killer. Why SAP + Qualtrics is a killer idea. And how Satya Nadella just might be the killer CEO of the decade. Sean also talks us through his belief that grocery chains, manufacturers, automotive companies, and others need to figure out what their own version of Disney+ looks like—and get started on building it. Because as Sean says, we cannot relegate innovation to a subset of the economy and a subset of society. See acast.com/privacy for privacy and opt-out information.

Each month, “Ammirati on Innovation” episodes will look at ways that the disruptive-startup mentality is spreading beyond young entrepreneurs to big established corporations. Serial entrepreneur, venture capitalist and Carnegie Mellon B-school professor Sean Ammirati, who sits at the intersection of these high-change dynamics, provides insight.Episode 2:In this episode, Sean – a Digital All-Star – and I discuss how Disney+ is a Netflix killer, how SAP and Qualtrics is a killer idea, and how Satya Nadella just might be the killer CEO of the decade. He also talks about how grocery chains, manufacturers, automotive companies, and others need to think about what’s my version of Disney+. See acast.com/privacy for privacy and opt-out information.

Each month, “Ammirati on Innovation” episodes will look at ways that the disruptive-startup mentality is spreading beyond young entrepreneurs to big established corporations. Serial entrepreneur, venture capitalist and Carnegie Mellon B-school professor Sean Ammirati, who sits at the intersection of these high-change dynamics, provides insight.Episode 1In this episode, Sean and I discuss what innovation looks like in 2019: where it’s coming from, who gets funding for their ideas and how, and why cloud has been so transformative in terms of the business models for entrepreneurs and innovators. Sean also shares his thoughts on the recent story about Lyft and Amazon’s $8-million-per-month partnership for AWS services. (Spoiler alert: he thinks it’s worth every penny.)Sean Ammirati is a partner at Birchmere Ventures, which focuses on both SaaS and consumer internet investments, as well as their Birchmere Labs initiative. He is also an Adjunct Professor of Entrepreneurship at Carnegie Mellon University’s Tepper School, and hosts a podcast series called “Agile Giants.”--Explore more in the Cloud Wars series - https://cloudwars.coListen to more episode of Cloud Wars Live - https://bit.ly/2WIYncvFollow Sean on Twitter - https://twitter.com/SeanAmmiratiFollow Bob on Twitter - https://twitter.com/bobevansIT See acast.com/privacy for privacy and opt-out information.

Each month, “Ammirati on Innovation” episodes will look at ways that the disruptive-startup mentality is spreading beyond young entrepreneurs to big established corporations. Serial entrepreneur, venture capitalist and Carnegie Mellon B-school professor Sean Ammirati, who sits at the intersection of these high-change dynamics, provides insight.Episode 1In this episode, Sean and I discuss what innovation looks like in 2019: where it’s coming from, who gets funding for their ideas and how, and why cloud has been so transformative in terms of the business models for entrepreneurs and innovators. Sean also shares his thoughts on the recent story about Lyft and Amazon’s $8-million-per-month partnership for AWS services. (Spoiler alert: he thinks it’s worth every penny.)Sean Ammirati is a partner at Birchmere Ventures, which focuses on both SaaS and consumer internet investments, as well as their Birchmere Labs initiative. He is also an Adjunct Professor of Entrepreneurship at Carnegie Mellon University’s Tepper School, and hosts a podcast series called “Agile Giants.”--Explore more in the Cloud Wars series - https://cloudwars.coListen to more episode of Cloud Wars Live - https://bit.ly/2WIYncvFollow Sean on Twitter - https://twitter.com/SeanAmmiratiFollow Bob on Twitter - https://twitter.com/bobevansIT See acast.com/privacy for privacy and opt-out information.

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GSAS! podcast correspondent Tara Gadomski attended the first performance of Tongue in Cheek Theater Productions‘ world premiere Relentlessly Pleasant, and hosted an interview/talkback with the audience, featuring writer/director Jake Lipman and dramaturg Jessica Ammirati. Listen in as they discuss “what it’s like to … Continue reading →

Episode 7 - In episode 7, we discuss Nora Ephron's uniquely Washington DC novel, HEARTBURN. Joining Jessica for the deep dive, is actor/producer/writer/director and founding artistic director of Tongue In Cheek Theater (www.tictheater.com), Jake Lipman* (www.jakelipman.com). The comfort food is (Nora-approved) mashed potatoes. Community Comfort is a new one for us at CM - a scent - specifically Calendula - courtesy of Jake. So, get yerself a bowl of hot mashed potatoes, some Kerrygold butter to mix on in, pick up your copy of HEARTBURN, and join Jess and Jake for a discussion of The Eastern Airlines Shuttle, handsome muggers, group therapy, and hamster-raising ex-husbands... *A special note - as Jessica mentions in the intro to the episode, as a dramaturge and associate producer, Jessica collaborated with Jake on the creation of a new play called Relentlessly Pleasant. The play is having it's world premiere run off-off-Broadway October 10th-27th, 2018 at Shetler Studios, 244 West 54th Street. For more information and to get tickets (if you happen to be in NYC for October) go to www.tictheater.com. As always, thank you to The Don't Tell Darlings for use of their songs "Never Saw Nothing" and "Till I Get Home" in the intro and outro (respectively) to the pod, and for the song "Guess That's Why" (underscoring the Comfort Comp). For more of Camilla's music you can go to www.donttelldarlings.com and www.facebook.com/UprootedStringBand Please feel free to rate and review Comfort Measures on iTunes and don't forget to subscribe to the show while you're there. You can get more Comfort Measures at www.patreon.com/comfortmeasures, www.facebook.com/comfortmeasurespodcast, www.twitter.com/ComfMeasuresPod, www.instagram.com/comfortmeasurespodcast.

Dr Carolyn Lam:                We start today's podcast with a few words from our Editor-in-Chief, Dr Joe Hill. Dr Joe Hill:                           I speak with you today with a heavy heart as we recently lost an esteemed and beloved colleague, Professor Bongani Mayosi. Bongani was a pioneering leader, a renowned investigator, Dean of the Medical School at the University of Cape Town, and an important member of our Circulation editorial leadership team.                                                 Bongani had an abiding passion for the under-served, especially those in his native Africa. He died tragically and suddenly at the early age of 51, just 10 days after recording the podcast you're about to hear.                                                 We mourn the loss of this colleague and our hearts go out to his family. It is a very poignant moment, as we hear his voice once again. We grieve deeply, and are reminded of Bongani's towering achievements and contributions to the betterment of our world. Dr Carolyn Lam:                Welcome to Circulation on the Run, your weekly podcast summary and backstage pass to the journal and its editors. I'm Dr Carolyn Lam, associate editor from the National Heart Center and Duke National University of Singapore.                                                 CD4-positive T cells play an important role in atherosclerosis, but their antigen specificity is poorly understood. Today's paper describes the first study to detect apolipoprotein B peptide 18 specific CD4 T cells in mice and humans. First author Dr Kimura, corresponding author Dr Ley from La Jolla Institute of Allergy and Immunology and their colleagues constructed novel P18 tetramers to detect human and mouse APOB-specific T cells and assayed their phenotypes by flow cytometry. They found that these P18 specific T cells were mainly anti-inflammatory regulatory T cells in healthy donors, but co-expressed other CD4 lineage transcription factors in patients with sub-clinical cardiovascular disease.                                                 Immunization with P18 reduced atherosclerotic burden in APOE deficient mice and induced antigen specific T regulatory cells. This study therefore, identifies APOB peptide 18 as the first T regulatory APOtope in human atherosclerosis.                                                 The next study suggests that testing intracellular calcium handling in circulating B lymphocytes may be a novel biomarker for monitoring patients with heart failure. During [inaudible 00:02:47] intracellular calcium is released from sarcoplasmic reticulum into the cytoplasm through Type II ryanodine receptor calcium release channels. In heart failure chronically elevated, circulating catecholamine levels cause pathologic remodeling of these Type II receptors, resulting in diastolic sarcoplasmic reticulum calcium leak, thus decreasing myocardial contract [inaudible 00:03:09]. Similarly, skeletal muscle contraction requires sarcoplasmic reticulum calcium release and this occurs through Type I ryanodine receptors. Chronically elevated catecholamine levels in heart failure cause Type I mediated sarcoplasmic reticulum calcium leak, thus contributing to skeletal myopathy and weakness.                                                 In today's paper, first author Dr Kushner. Co-corresponding authors Dr Kitsis from Albert Einstein College of Medicine and Dr Marx from Columbia University, New York hypothesized, that since circulating B lymphocytes express Type I ryanodine receptors, they may be a potential surrogate for defects in intracellular calcium handling due to leaky ryanodine channels in heart failure. Indeed, they found that circulating B lymphocytes from humans and mice with heart failure exhibited remodeled Type I ryanodine receptors and decreased endoplasmic reticulum calcium stores, consistent with chronic intracellular calcium leak. This calcium leak correlated with circulating catecholamine levels. The intracellular calcium leak was significantly reduced in mice treated with S107, which is a drug that specifically reduces ryanodine receptor calcium leak.                                                 Furthermore, heart failure patients treated with LVADs exhibited a heterogenous response. Thus, Type I ryanodine receptor mediated calcium leak in B lymphocytes assessed using flow cytometry may provide a surrogate measure of intracellular calcium handling and systemic sympathetic burden and therefore represent a novel biomarker strategy for monitoring the responses in heart failure therapy.                                                 Hypouricemia and gout are known to be associated with increased risk of cardiovascular disease. And xanthine oxidize inhibitors such as allopurinol and febuxostat are the mainstay of urate lowering treatment of gout, but do they have different effects on cardiovascular risk? First author, Dr Jong, corresponding author, Dr Min from Brigham and Women's Hospital Harvard Medical School in Boston, Massachusetts, studied a cohort of almost 100,000 older Medicare patients with gout and found that there was, overall, no difference in the risk of MI, stroke, new onset heart failure, coronary revascularization are all cause mortality between patients initiating febuxostat compared to those initiating allopurinol. However, there did seem to be a trend toward an increased opiate not statistically significant risk for all-cause mortality in patients who use febuxostat for over three years compared to allopurinol use for over three years. The risk of heart failure exasperation was slightly lower in febuxostat initiators.                                                 The final original paper this week provides important contemporary data on the clinical characteristics in hospital management and long-term outcomes of patients with acute myocarditis. Co-corresponding authors, Dr Ammirati and Kamichi, both from Milan, Italy and their colleagues screened 684 patients with suspected acute myocarditis and recent onset of symptoms within 30 days between May 2001 and February 2017 and included 443 patients with acute myocarditis diagnosed either by endomyocardial biopsy or by increased troponin and edema and late gadolinium enhancement on cardiac magnetic resonance imaging. They showed that among these 443 patients, 118 patients or 26.6% had either left ventricular ejection fraction less than 50% sustained ventricular arrhythmias or a low cardiac output syndrome. While, the 73.4% had no such complications.                                                 Cardiac mortality and heart transplantation at five years was 4.1%, but went up to 14.7% in the patients with complicated presentation and contrast down to zero percent in the uncomplicated cases. Similarly, major acute myocarditis related cardiac events after the acute phase, such as post discharge death and transplantation, sustained ventricular arrhythmias, symptomatic heart failure needing device implantation all occurred in 2.8% at five years, but was much higher in patients with a complicated presentations at 10.8% versus zero percent in the uncomplicated presentations. Thus, the authors concluded that patients with acute myocarditis can be effectively stratified based on their initial clinical presentation. Patients with left ventricular ejection fraction less than 50% at the first echo. Those with sustained ventricular arrhythmias or those with low cardiac output syndrome are at higher risk of cardiac events compared to those without these manifestations.                                                 And that brings us to the end of our summaries. Now, for our feature discussion.                                                 With advances in therapy most deaths in people with HIV are now due to noncommunicable diseases, especially cardiovascular disease. What does the global burden of HIV associated cardiovascular disease really look like? Well we're going to get some answers in today's feature paper. I have with us today the first and corresponding author of the paper, Dr Anubshaw from University of Edinburgh, as well as our associate editor, Dr Bongani Mayosi from University of Cape Town in South Africa. Dr Carolyn Lam:                Welcome to you both. And Anub, what an important question to examine. Could you tell us how you looked into this question and what you found? Dr Anubshaw:                   Sure. So, this is a very interesting question from our end and we had in short idea looking at the risk of cardiovascular disease in patients with HIV. And there are many studies of it, varying results. I'm looking at the risk of heart disease and stroke in patients with HIV. So, what we did was a big systematic review to extract all the data out there looking at the risk of heart disease in patients with HIV, we then developed a model that looked at what the overall risk was and then tried to calculate the actual burden of cardiovascular disease attributable to patients with HIV. In some of the work we found, well, primarily we found that the majority of the burden, as expected in Sub-Saharan Africa and that is primarily the cause, in prevalence of HIV is the highest in Sub-Saharan Africa, accounting for about two thirds of all people living with HIV. Dr Anubshaw:                   The risk of cardiovascular disease with patients with HIV is twofold higher compared to patients not infected by virus. And there was not [inaudible 00:10:12] variations in the actual burden. The majority of the burden in Sub-Saharan Africa and Southeast Asia. Dr Carolyn Lam:                Wow, Sub-Saharan Africa and Asia Pacific, isn't it? Oh my goodness, Bongani, your views please on these standing results from Africa. Dr Bongani Mayosi:         Yes. I think these results are actually very important in the Sub-Saharan African region, reaching the, at the center of the HIV/AIDs epidemic in the world. And particularly important now that we are finding people and are on treatment and that they are growing older and there's a thriving proportion of people above the age of 60, they are on HIV infection and therefore the whole question of cardiovascular disease in these patients has become very important and clearly now these data suggest that HIV [inaudible 00:11:08] for cardiovascular disease, but what is more important [inaudible 00:11:14] they are important [inaudible 00:11:17] for cardiovascular disease, but also a [inaudible 00:11:22]. [inaudible 00:11:23] such as another vascular condition, which is pulmonary hypertension associated with HIV detection. [inaudible 00:11:35] with the increase of the number of people on treatment, these particular conditions are becoming [inaudible 00:11:43] in the context of how to [inaudible 00:11:48], but is an important condition in the African continent. So that the overall burden of cardiovascular disease is likely to be greater than is estimated here because the study is only estimating atherosclerotic cardiovascular disease. Dr Anubshaw:                   That brings up a very intriguing question, Anub. Could you at all distinguish between atherosclerotic risk factors and the role that played versus more HIV specific risk factors, such as the medication, the degree of HIV control, level of inflammation, for example? Now, of course in a meta-analysis this may be difficult, but just your thought.                                                 You're absolutely right from a meta-analysis point of view it's very difficult for a couple of reasons. Firstly, we do not have individual patient level data, so we couldn't really see a [inaudible 00:12:45] level which patients are on [inaudible 00:12:47] therapy and what their personalized risk factors are. Varying schools of thought estimated around the candidates that they need, which kind of portrays a risk of heart disease in the [inaudible 00:12:59] artery in patients with HIV. And what we think may be happening there, one that HIV represents a degree of sub-clinical inflammation that leads to vascular inflammation, which then leads to accelerated atherosclerosis and there's some fantastic mechanistic evidence looking at this where, workers have looked at vascular inflammation in the arteries in patient HIV can go through control and you do get much more vascular inflammation. There is some evidence about the fact that the [inaudible 00:13:31] therapy itself can cause [inaudible 00:13:34] and therefore increase the risk of atherosclerotic heart disease.                                                 And finally, some risky behavior is probably much more, have a look at HIV for example, smoking entered the [inaudible 00:13:46] etc., etc. and there may be a degree of overlap in terms of or correlation in terms of risk factors being much more common in HIV patients, which are more conditional for atherosclerotic heart disease. I think a combination of all those three things probably explain the increase risk of atherosclerotic heart disease and strokes in these patients. Dr Carolyn Lam:                Indeed. Your paper is so important to raise awareness of that very risk. I mean, if I could please re-iterate, you show very clearly that people with HIV are the two fold increase risks of cardiovascular disease and that that global burden had tripled over the last two decades. I think that your paper really shines a bright light in this area, that we have to study further because the clinical implications are enormous aren't they? Because we're using guidelines developed in non-HIV patients to perhaps treat these cardiovascular diseases in HIV patients and there may be other pathophysiologic mechanisms like you just mentioned. What do you think are the main clinical implications of your paper? Dr Anubshaw:                   The clinical implication is quite important because what the burden estimate show is that the majority of burden is in no or little information and therefore the resource of those innovations are quite limited, but there's one condition that has been treated so well in these countries. One of the main success stories of medicine, over the last two or three decades and how they've tackled HIV, who runs PEP for has made intrical virals available so widely in the Sub-Saharan African regions, while there's other highly prevalent regions. And they set up logistically clinics to deliver and scare for persons with HIV and if you and I will see that the survival in these patients [inaudible 00:15:39] just mentioned. Then, these patients are at more high risk of other among AIDs related conditions, such as strokes and heart disease. What you now have in these poor resource countries or limited resource countries, where clinics and the logistical support is only set up to deliver cardiovascular risk prevention strategies and therapy. Which is not expensive in terms of antihypertensives, in terms of [inaudible 00:16:06] and in terms of lifestyle factors.                                                 So, I think there is [inaudible 00:16:10] here that the region has to further reduce the cardiovascular burden in this population. Dr Carolyn Lam:                Bongani, you too recognize the very important clinical implications and in fact invited the editorial by Priscilla Sue and David Waters from San Francisco General Hospital. I love the title of it. Is it time to recognize HIV as a major cardiovascular risk factor? Bongani, what are your thoughts? Dr Bongani Mayosi:         I think it is time we should be considering the HIV as a risk factor for cardiovascular disease. You know these data arriving from this [inaudible 00:16:48] are quite compelling and when you look, for example at that this is a hot study [inaudible 00:16:55] in the editorial and conferred by HIV, it is almost the same as the other [inaudible 00:17:02]. I mean if you go into it now that in fact the European Society of Cardiology it is already [inaudible 00:17:12] in HIV infected individuals with [inaudible 00:17:19]. So, if now may be entering their [inaudible 00:17:27] of practice, they consider HIV as a significant risk factor for cardiovascular disease and maybe contribute to bring a drug that will modify outcome. I do think though that because of the mechanism of cardiovascular disease it [inaudible 00:17:45] HIV it is not common on the basis of atherosclerotic disease. In Africa as an example, we know very well that the patient tend to [inaudible 00:17:55] with not a lot of traditional risk factors of cardiovascular disease, in fact, atherosclerotic diseases such as [inaudible 00:18:07] still have a relatively low level of [inaudible 00:18:10].                                                 So, we still, I think need to discover what are the other [inaudible 00:18:14] mechanisms that are involved, I mean they do that very much more targeted drug [inaudible 00:18:21] where it needs to be tested, that don't know our traditional interventions for reducing risk and preventing cardiovascular disease. So, there is need for further research here and the mechanisms and specific intervention. That is the important in this large HIV infected populations because at the moment there at least 27 million people in the world, living with HIV who already facing a major public health issue on a global scale. Dr Carolyn Lam:                Exactly and all these new research efforts, paying attention to this, making sure that we don't underestimate cardiovascular risk and HIV based on traditional risk calculators. All of this starts with awareness and with important papers such as yours, Anub. Thank you so much for publishing that with us at Circulation.                                                 Well, listeners you know how important this is globally, so please share this podcast with your colleagues and don't forget to tune in next week.  

Nancy Kramer started and grew her marketing agency, Resource Ammirati, into a behemoth of an agency in Columbus. Her agency was purchased by IBM in 2016. Kramer is an incredibly talented marketer, entrepreneur, and leader. For all of these reasons, she's the *perfect* first guest for Differential. If you enjoy listening to this episode, please give us a review!   twitter.com/_differential_

Carolyn:               Welcome to Circulation on the Run, your weekly podcast summary and backstage pass to the journal and its editors. I'm Dr. Carolyn Lam, Associate Editor from the National Heart Center and Duke National University of Singapore.                                 Later on in this podcast, we will be meeting Dr. Nancy Schweitzer, Editor-in-Chief of the new Circulation Heart Failure. We will be discussing today's feature paper on acute myocarditis as well as hearing about her visions for the journal. All that coming right up after these summaries.                                 The first original paper this week suggests that day-to-day blood pressure variability may be a significant risk factor for dementia. First author Dr. Oishi, corresponding author Dr. Ohara, and colleagues of Kyushu University from Fukuoka, Japan, studied a total of 1,674 community-dwelling Japanese elderly without dementia, who were followed up for five years, and had home blood pressure measured three times every morning for a median of 28 days.                                 They found that the age and sex adjusted incidences of all-cause dementia, vascular dementia, and Alzheimer's disease increased significantly with increasing day-to-day variability of home systolic blood pressure. These associations remained unchanged after adjusting for potential confounding factors, including average home systolic blood pressure. The study, therefore, suggests that the measurement of day-to-day blood pressure variability, using home blood pressure monitoring, may be a useful way to assess future risk of dementia, irrespective of dementia subtype.                                 The next paper is one of the first studies to directly target a gene within the fibroblast of a mammalian heart and show a direct role in regulating cardiac fibrosis. Co-corresponding authors Dr. Molkentin from Howard Hughes Medical Center and Cincinnati Children's Hospital Medical Center and Dr. Davis from University of Washington and colleagues performed an elegant series of mouse experiments to show that the gene-encoding p38 alpha mitogen-activated protein kinase was required to mediate fibroblast activation in the mouse heart following injury.                                 They also showed that forced activation of p38 within fibroblasts, using a transgenic approach, was sufficient to drive fibrosis in multiple tissues of the mouse, including the heart.                                 In totality, their findings indicated that p38 mitogen-activated protein kinase was a nodal signaling effector within the cardiac fibroblast that drove both wound healing and long term fibrosis in heart failure. In other words, it appears to play a crucial role in the control of both physiological and pathological processes. The clinical implications are that pharmacologic inhibition of p38 mitogen-activated protein kinase in heart failure could reduce progressive fibrosis. However, the same inhibition during acute myocardial infarction injury may inhibit wound healing and be detrimental. These issues are discussed in an accompanying editorial by doctors, Stratton, Koch and McKinsey.                                 Receptors, well known for their roles in angiogenesis and cancer, may play a role in atherosclerosis, as shown in the next paper, which looked at the Eph-family of receptor tyrosine kinases. These are the largest family in the mammalian genome, which interact with ephrin ligands on adjacent cells to mediate cell adhesion repulsion signaling.                                 First author, Dr. Finney, corresponding author, Dr. Orr, from LSU Health Sciences Center, Shreveport, and colleagues assessed the role of EPHA2 in atherosclerosis by deleting the EPHA2 in a mouse model of atherosclerosis and by assessing EPHA2 function in multiple vascular cell culture models.                                 The authors identified a novel role for EPHA2 in atherosclerosis by regulating both plaque inflammation and progression to advance atherosclerotic lesions. Cell culture studies suggested that endothelial EPHA2 contributed to atherosclerotic inflammation by promoting monocyte firm adhesion, whereas, smooth muscle EPHA2 expression regulated the progression to advanced atherosclerosis by regulating smooth muscle proliferation and extracellular matrix deposition.                                 The clinical implications are that blunting EPHA2 ligation may selectively reduce plaque-associated inflammation. Since the effect of EPHA2 on smooth muscle proliferation appears to be largely ligand independent, unlike its effect on inflammation, the blunting of EPHA2 ligation may limit inflammation while leaving smooth muscle fibroproliferative remodeling intact.                                 Well, that wraps it up for our summaries. Now, let's go to our feature discussion.                                 Our feature paper today may cause us to think a little bit differently about fulminant versus non-fulminant acute myocarditis because the findings are actually in contrast with previous studies and are extremely insightful.                                 And, to discuss this, I am so pleased to have the corresponding author, Dr. Enrico Ammirati from Niguarda Hospital in Milan, Italy, as well as Dr. Nancy Sweitzer, Associate Editor of Circulation from University of Arizona, who managed this paper. But importantly, also, the Editor In Chief of Circulation Heart Failure. Welcome, Enrico and Nancy. Enrico:                  Hello. Nancy:                  Thank you, Carolyn. Carolyn:               Enrico, could I ask you to start by clarifying the conditions that we're talking about here? When we say acute myocarditis or fulminant myocarditis, and non-fulminant myocarditis, what exactly are we referring to? Enrico:                  We refer to an acute condition and fulminant myocarditis is a myocarditis inflammation of the myocardium that's a media anatomic or mechanical support due to an anatomic instability, while non-fulminant myocarditis it's a condition where the patient remains hemodynamically stable. Previous records have suggested that despite their dramatic presentation of patient with a fulminant myocarditis might have better outcome than those with acute fulminant myocarditis.                                 Now in this study we have over 55 patients with fulminant myocarditis and in particular, 34 patients with fulminant myocarditis with viral genomes within two weeks from the onset of symptoms, whereas in the previous record, in particular from [inaudible 00:07:38] we have shown in 15 occasions of fulminant myocarditis, that fulminant myocarditis as quite a good prognosis.                                 But what we believe it is that gives disparity between our results that connected all acute patients admitted to the emergency department with [inaudible 00:08:01] and symptoms onset within one month to two weeks before. Is the main difference comparing [inaudible 00:08:11] this study [inaudible 00:08:13] patient with onset of symptoms since one year before the onset of symptoms. And we believe that we enroll acute patients.                                 Whereas in the other study, there was sort of selection by us. It was true that in those previous studies, they have all just patients who we were endomyocardia biopsied performed whereas in our study we did not perform endomyocardia biopsies in that case. But we feel that we have a snapshot of the acute stage of a fulminant myocarditis, so we connected all the patients, whereas in previous study, maybe some of the patients they had acute symptoms died before evaluation from the other researchers. Carolyn:               Indeed, it makes a lot of sense that there may be some survival bias involved. For example, if the sickest patient didn't get a biopsy, for example.                                 Nancy, when you were managing this paper, what were the kind of the discussions that occurred at the editorial discussions? Nancy:                  I think that Dr. Ammirati pointed it out really well. The editors felt that this was a very important paper because it really looked inclusively at myocarditis in the modern era, and showed us where perhaps bias in prior studies had led us astray in terms of our beliefs about, particularly the outcomes in this syndrome. Not only the outcomes in the fulminant patients, who have a very profound and important early mortality risk, but also the outcomes in the non-fulminant patients, who in this study, really do extremely well and do not progress to LV dysfunction, which has been a long-held belief, I think. So understanding much better the full spectrum of myocarditis was made much easier because of the comprehensive look Dr. Ammirati and his colleagues took. Carolyn:               Enrico, I do congratulate you on a beautiful paper. As I said, as a heart failure cardiologist myself, it has changed my thinking. Could you maybe share just a bit more details of what your study found and how this is important clinically? Enrico:                  What we have found it is that hospital deaths or heart transplantation was about 25 percent in fulminant myocarditis compared to ten percent in non-fulminant myocarditis and despite greater improvement in the left ventricle injection fraction [inaudible 00:10:56] in fulminant myocarditis compared to non-fulminant forms. The proportion of patients with the left ventricle injection fraction below 55% [inaudible 00:11:09] was higher in fulminant myocarditis comparing it to non-fulminant myocarditis. So we have to pay great attention to do this form of myocarditis not thinking that this is a condition that can simply recover with time but we have to aggressively manage this condition, and we have to see about trials designed [inaudible 00:11:39] in this specific setting to improve the [inaudible 00:11:50] outcome and to reduce myocardial injury during the acute phase. Carolyn:               True. And Nancy, I mean you see tons of these patients too. How has this impacted you? Nancy:                  It's interesting, it definitely has impacted me. I like everyone, taught and taught on my teaching rounds for many years that the fulminant patients we were seeing, despite how ill they were, would have better outcomes than those who were non-fulminant. And also, many patients who present with dilated cardiomyopathy who are non-ischemic are told after searching for some viral illness in the year prior to their presentation that probably they had a virus attack the heart or an inflammation of the heart. I've stopped saying those things, and I continue to see review of papers that I'm handling about myocarditis refer to these misconceptions. So I think this is going to be a really important paper, and clarifying our understanding of how this disease evolves over time. Enrico:                  I fully agree, I fully agree with this message, and [inaudible 00:12:54] but I believe that the traditions that are involved in [inaudible 00:13:00] maybe can be misleading for other cardiologists. Carolyn:               Nancy, I'm gonna switch tracks a little bit, I mean your explanation of that already gets me so excited about the kinds of papers that are gonna get to be seen at the new Circulation Heart Failure under your leadership. So could you just tell us a little bit more about your vision as editor-in-chief. Nancy:                  Well Carolyn, Circulation Heart Failure is an excellent journal Dr. [inaudible 00:13:33] has stewarded it beautifully in its first decade of life. In many ways I don't want to change the journal, I want the very best science that's helping us have a deeper understanding of the disease processes and therapies that affect our patients. That said, I would say we have a couple new initiatives, or sort of slight differences in how we're going to manage the journal going forward. I must say, the content we get is spectacular, and we're so fortunate to be able to look through the papers we get, and try to choose the very best science. It's an amazing privilege for me and the new team.                                 We're really interested in young investigators and those people who are starting out in their career. The emerging scientists who are producing the best heart failure science. Early in your career you might not have the weight of data behind you to merit publication and circulation proper, but we hope that with good science well thought out excellent hypotheses, Circulation Heart Failure will be an appropriate target for those emerging investigators.                                 We found some great pleasure in approaching young scientists at meetings, and discussing their work, and asking them to send it to our journal. And that's been great fun and we've seen wonderful yield from that. We've been getting submissions from people we've spoken to whose work we admire, and we really hope to build that part of the journal up. Hand in hand with that is an effort at building our social media presence. We're an entirely online journal. We're very interested in visually appealing content. We do have an images in case report section. And we're going to work to try to build an online community for our young investigators who may not have the money to travel internationally, but who really needed global community of heart failure research colleagues, and we hope to be a place to build that.                                 And finally, we're interested in some areas that maybe, are emerging or underrepresented in other journals. Areas like ... the way technology is transforming heart failure mechanical circulatory support devices, wearable devices, the other technologies we're using increasingly in our patients. And the world of pulmonary hypertension, and right ventricular dysfunction, which is sort of searching for a journal home, and we hope that we can be that journal home. And of course representing the full spectrum of therapies for heart failures including transplantation. I already mentioned mechanical circulatory support, you know, all the richness that is the evolving field of heart failure, and how we ... I think as professionals in that field think about and treat our patients a little differently than other people caring for heart failure. Carolyn:               Listeners, you just heard it right here, on Circulation on the Run.                                 Thank you so much for joining us this week. Tune in again next week for even more exciting news.

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In the latest episode of “The A-List” podcast, host and DiMassimo Goldstein Chief Creative Officer Tom Christmann sits down with creative maestro Dan Kelleher, Chief Creative Officer at Deutsch. Dan has worked at many of the world's most renowned agencies, including Saatchi & Saatchi, BBDO, Cliff Freeman & Partners, and DeVito/Verdi. His work for brands such as BMW, DIRECTV, General Mills, FedEx, and Guinness has earned some of the industry's top awards. Bill Clinton once said that his favorite commercials were the “Cable Effects” spots for DIRECTV, which Kelleher helped bring to life. Dan was also responsible for bringing us the BMW Super Bowl ad, “Newfangled Idea,” which Ad Age ranked among the best Super Bowl ads of all time. Tune in to hear Dan discuss how perseverance paved his path to success, what today's creatives can learn from the “funny vs. not funny” wall, and why honesty is the key to great client relationships. Show Notes • [0:00 – 1:35] Intro • [1:36 – 7:04] Growing up in Plainfield, New Jersey, being passionate about art and deciding that medical illustration wasn't the right field for him • [7:05 – 11:35] The Rocky of advertising: how perseverance landed him his first job in the print production department of Ammirati & Puris • [11:36 – 20:39] Working on his portfolio, attending ad school, and learning the ropes from great bosses • [20:40 – 29:32] Getting hired in his first creative role as junior art director at DeVito/Verdi • [29:33 – 34:36] Moving to Cliff Freeman & Partners and selling his first TV spot for Staples • [34:37 – 43:44] Lessons for young creatives from the “funny vs. not funny” wall • [43:45 – 49:14] Dan and Tom discuss their time at BBDO working for Gerry Graf • [49:15 – 54:32] Working at BBDO, getting more client interaction, and filming with Burt Reynolds • [54:33 – 59:50] The importance of honesty in developing great client relationships • [59:51 – 62:24] The value of building a strong agency culture • [62:25 – 69:20] What Dan looks for in a portfolio today and his one piece of advice for young creatives • [62:21 – 70:50] Outro “The A-List” is a podcast produced by DiMassimo Goldstein, recorded at the Gramercy Post, and sponsored by the Adhouse Advertising School, New York's newest, smallest, and hippest ad school. You can subscribe to and rate the show on iTunes or listen along on SoundCloud. For updates on upcoming episodes and guests, be sure to like “The A-List” Podcast on Facebook and follow host Tom Christmann on Twitter. If you want to be interviewed for an upcoming episode, contact us at AdhouseNYC.com.

Sean Ammirati joined Birchmere Ventures in 2012 to as the partner leading Birchmere Labs, a seed and studio fund focused on community driven commerce start-ups. Prior to that, he had over 12 years founding, building and selling businesses in the media and software industries. Sean was previously Chief Operating Officer of ReadWriteWeb, one of the most influential sites about the future of technology and innovation. In December 2011, the company was acquired by SAY Media to strengthen its technology channel. Sean was previously co-founder and CEO of mSpoke, which was the first acquisition of LinkedIn.   Sean is currently an Adjunct Professor of Entrepreneurship at Carnegie Mellon University. He also was a founding advisor to Innovation Works’ AlphaLab accelerator. He holds a B.S. in computer information systems from Grove City College and was a research fellow at Carnegie Mellon’s Sloan Software Industry Center.   Check out his new book about how lean startups can find growth; The Science of Growth: How Facebook Beat Friendster--and How Nine Other Startups Left the Rest in the Dust   Sean’s Challenge; We need to do a better job conditioning ourselves to understand that failure is not as scary as we tend to think it is.   Connect with Sean Twitter LinkedIn Website   If you liked this interview, check out episode 16 with Zach Malone where we discuss raising venture capital and the Pittsburgh startups scene.

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"Le voci intorno" di Maria Pia Ammirati 1F lezione scolastica - prof. Luigi Gaudio

http://www.thesaleswhisperer.com/blog/topic/podcast http://MakeEverySale.com * The written word still matters * Even in video, the best videos are written first * Think in terms of scenes * Do the research to understand your customers * Interview your customers * Ally and Gargano ( https://amzn.to/2IoJkwv ) > > > > The last thing we do is write the ads. > > * " The Book of Gossage ( https://amzn.to/2tDJ72S ) " * When in doubt, hire the better writer * "Email is the red-headed stepchild of online marketing. But it's hard, thankless work." * Dan Kennedy reminds us to crunch the numbers to determine which medium to use to get your word out * *"Opinion drools and testing rules."* * To use mass audience it must have mass-appeal * An appreciable size of your audience must need what you sell within a few years * You want to reach the average listener three times in a week, for 52 weeks * Salespeople only speak to people when they want to buy something so your prospects view your message with suspicion * When you are running branding campaigns you can reach people when their guards are down * It's "the sleeper effect" * Your conscience bias discounts the message but it works on you over time * Bob Lutz hired a marketing firm, Ammirati & Puris, for BMW to create "The ultimate driving machine" * If you're really local look at Cable TV for advertising on certain zip codes * The best advertising is an intrusive location * Pick a good client who is good at what they do and runs a tight ship * Build your campaign around a promise they can keep and is baked into how they do things * There are no rational business owners * Sales training for non-sales professionals * Clerks * Medical practice front desk staff * Traffic is expensive so get your conversions down before you throw more traffic at your offer * How the curse of knowledge is hurting your sales * Buy one of the Wizard of Ads books * Magical Worlds of the Wizard of Ads: Tools and Techniques for Profitable Persuasion ( https://amzn.to/2MWPveo ) * Secret Formulas of the Wizard of Ads: Turning Paupers into Princes and Lead into Gold ( https://amzn.to/2MYgmqt ) * The Wizard of Ads: Turning Words into Magic and Dreamers into Millionaires ( https://amzn.to/2IqlLTG ) * Schedule time to do customer research * Interviews * Speaking to your staff * Dig into online forums * Buy the Ally & Gargano book and study it * Hire Jeff * Go run a test. Re-think your messaging. Support this podcast at — https://redcircle.com/the-sales-podcast/exclusive-content Advertising Inquiries: https://redcircle.com/brands Privacy & Opt-Out: https://redcircle.com/privacy