Podcasts about Prevotella

Story at-a-glance Research found that higher levels of harmful bacteria (Prevotella intermedia) in the mouth are linked to cognitive impairment, while beneficial bacteria (Neisseria and Haemophilus) support better brain function Nitric oxide production by beneficial oral bacteria plays a crucial role in maintaining blood flow to the brain. Nitrate-rich vegetables help boost the population of these healthy bacteria People with the APOE4 gene show a distinct oral microbiome composition. Research shows they have lower levels of Neisseria bacteria and higher amounts of Prevotella, which is associated with increased dementia risk Harmful oral bacteria have the ability to enter the bloodstream and cross the blood-brain barrier, leading to brain inflammation that results in cognitive decline Maintaining oral health through proper diet, regular brushing and flossing, nose breathing, avoiding antibacterial mouthwash and practicing oil pulling are effective strategies against cognitive decline

The Role Meat May Play in Triggering Parkinson's Disease  What does the gut have to do with developing Parkinson's disease? Check out today's episode to find out more. Written by Dr. Michael Greger at @NutritionFacts.org #vegan #plantbased #plantbasedbriefing #parkinsons #prevotella #fiber #gutmicrobiome #leakygut ============================ Original post: https://nutritionfacts.org/video/the-role-meat-may-play-in-triggering-parkinsons-disease/  Related Episodes: Tobacco Industry Playbook, 92: No Purveyor of Unhealthy Products Wants the Public to Know the Truth https://plantbasedbriefing.libsyn.com/92-no-purveyor-of-unhealthy-products-wants-the-public-to-know-the-truth  ============================ Dr. Michael Greger is a physician, New York Times bestselling author, and internationally recognized speaker on nutrition, food safety, and public health issues. A founding member and Fellow of the American College of Lifestyle Medicine, Dr. Greger is licensed as a general practitioner specializing in clinical nutrition. He is a graduate of the Cornell University School of Agriculture and Tufts University School of Medicine. He founded NUTRITIONFACTS.ORG is a non-profit, non-commercial, science-based public service provided by Dr. Michael Greger, providing free updates on the latest in nutrition research via bite-sized videos. There are more than a thousand videos on nearly every aspect of healthy eating, with new videos and articles uploaded every day.   His latest books —How Not to Age, How Not to Die, the How Not to Die Cookbook, and How Not to Diet — became instant New York Times Best Sellers. His two latest books, How to Survive a Pandemic and the How Not to Diet Cookbook were released in 2020.  100% of all proceeds he has ever received from his books, DVDs, and speaking engagements have always and will always be donated to charity. ============================== FOLLOW THE SHOW ON: YouTube: https://www.youtube.com/@plantbasedbriefing     Spotify: https://open.spotify.com/show/2GONW0q2EDJMzqhuwuxdCF?si=2a20c247461d4ad7 Apple Podcasts: https://podcasts.apple.com/us/podcast/plant-based-briefing/id1562925866 Your podcast app of choice: https://pod.link/1562925866 Facebook: https://www.facebook.com/PlantBasedBriefing   LinkedIn: https://www.linkedin.com/company/plant-based-briefing/   Instagram: https://www.instagram.com/plantbasedbriefing/   

In this episode of The Autoimmune RESET,  VJ explores the intricate connections between rheumatoid arthritis (RA), gut health, and dental health. VJ begins by delving into the fundamentals of RA, including its diagnosis and underlying causes, emphasising the role of genetics, environment, and immune dysregulation in disease development.Next, VJ examines the emerging evidence linking gut dysbiosis to RA, highlighting key bacteria such as Prevotella copri and Faecalibacterium prausnitzii that may influence disease progression. Similarly, VJ explores the potential impact of periodontal disease bacteria, particularly Porphyromonas gingivalis, on RA pathogenesis, underscoring the importance of oral hygiene in RA management.Throughout the episode, VJ discusses practical strategies to support gut and dental health in those with RA, including dietary interventions, probiotics, oral hygiene practices, and stress management techniques. By adopting a holistic approach that addresses the interconnected aspects of RA, you can empower yourself to manage symptoms better, improve overall well-being, and enhance your quality of life.You can watch Nutrition Essentials for Joint Health here. You can download your free copy of The Autoimmune RESET here.And you can access all of VJ's free resources here.If you would like to book a free initial consultation with VJ Hamilton, The Autoimmunity Nutritionist, to find out how nutritional therapy and functional medicine could improve your health, you can book an appointment here.Learn more about the functional medicine services at The Autoimmunity Nutritionist Clinic here.Thanks for listening! You can join The Autoimmune Forum on Facebook or find me on Instagram @theautoimmunitynutritionist.

The connection between alcohol and gut health is established in scientific literature: alcohol is an inflammatory agent. But as researchers like Vincent Maffei work to improve the quality of life for HIV patients, every bit of information of how that inflammation develops makes a difference, especially in how alcohol and bowel problems connect. Listeners will learn The difference between chronological and biological health and how HIV patients experience increased biological aging, The connection between alcohol and G.I. issues, particularly less diverse microbiota, and The significance of their findings, specifically the abundance of Prevotella spp., a bacteria that may be a mediator between alcohol and cell senescence. Vincent J. Maffei is with the Department of Microbiology, Immunology, and Parasitology at LSU. As a graduate student, he became involved in LSU's Comprehensive Alcohol Research Center (CARC) and studied how dysbiosis accompanies biological aging. He combined this with studying how alcohol affects the intestines, and now studies this specifically with HIV patients. More specifically, he works to find associations between alcohol use and advancing aging in HIV patients and their guts. He explains to listeners about several players in this complex mix of cause and effect: alcohol and gut health as well as alcohol and HIV patients. He establishes that any amount of alcohol can be harmful to someone suffering from HIV. Combine that with an already-established connection with alcohol and dysbiosis in the gut, and researchers are faced with a very real problem to solve for these patients. He does a careful job explaining the background to listeners, bringing in other studies more general to alcohol use and explaining its effect on T-cell senescence, which basically means they lack the ability to copy themselves—limiting their ability to fight infection. Senescence is also a characteristic of biological aging. He explains that the administration of alcohol breaks down the gut barrier, allowing microbes to migrate from the lumen of gut into tissue, which causes inflammation. He also explains their worthy end goal: to identify some sort of microbiota intervention to relieve this component of inflammation in HIV patients, improving their life span and quality of life. Hopefully their findings will lead to more precise mechanisms that can be leveraged in therapeutic modality. For more, see the CARC website: medschool.lsuhsc.edu/alcoholresearch. Take advantage of a 5% discount on Ekster accessories by using the code FINDINGGENIUS. Enhance your style and functionality with premium accessories. Visit bit.ly/3uiVX9R to explore latest collection. Episode also available on Apple Podcasts: apple.co/30PvU9C

The Oral Bacteria Prevotella intermedia and its Link to Gout and Hyperuricemia By Katie Melko, RDH, MSDH Original article published on Today's RDH: https://www.todaysrdh.com/the-oral-bacteria-prevotella-intermedia-and-its-link-to-gout-and-hyperuricemia/ This audio article is sponsored by Philips Oral Healthcare. See firsthand how 30 years of innovation has made Philips Sonicare the #1 dental professional recommended power toothbrush brand. Take advantage of exclusive trial pricing for dental professionals by visiting ⁠⁠⁠⁠⁠⁠⁠proshop.philips.com⁠⁠⁠⁠⁠⁠⁠.   Need CE? Start earning CE credits today at ⁠⁠⁠⁠⁠⁠⁠https://rdh.tv/ce⁠⁠⁠⁠⁠⁠⁠  Get daily dental hygiene articles at ⁠⁠⁠⁠⁠⁠⁠https://www.todaysrdh.com⁠⁠⁠⁠⁠⁠⁠ Follow Today's RDH on Facebook: ⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/TodaysRDH/⁠⁠⁠⁠⁠⁠⁠ Follow Kara RDH on Facebook: ⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/DentalHygieneKaraRDH/⁠⁠⁠⁠⁠⁠⁠ Follow Kara RDH on Instagram: ⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/kara_rdh/⁠⁠⁠

Videos: Brought to you by… Pfizer! FORMER PFIZER VP, DR. MIKE YEADON – EVERYTHING WE HAVE BEEN TOLD ABOUT COVID-19 WAS A LIE Fauci didn't want autopsies done on Covid victims. I wonder why? Dr. Peter McCullough SLAMS Pfizer board member over censorship and propaganda | Redacted News Study explores effects of dietary choline deficiency on neurologic and system-wide health Arizona State University, January 16, 2023 Choline, an essential nutrient produced in small amounts in the liver and found in foods including eggs, broccoli, beans, meat and poultry, is a vital ingredient for human health. A new study explores how a deficiency of dietary choline adversely affects the body and may be a missing piece in the puzzle of Alzheimer's disease. It's estimated that more than 90% of Americans are not meeting the recommended daily intake of choline. The current research, conducted in mice, suggests that dietary choline deficiency can have profound negative effects on the heart, liver and other organs. Lack of adequate choline is also linked with profound changes in the brain associated with Alzheimer's disease. These include pathologies implicated in the development of two classic hallmarks of the illness: amyloid plaques, which aggregate in the intercellular spaces between neurons; and tau tangles, which condense within the bodies of neurons. The new research, led by scientists at Arizona State University and published in Aging Cell, describes pathologies in normal mice deprived of dietary choline and in choline-deficient transgenic mice, the latter of which already exhibit symptoms associated with the disease. In both cases, dietary choline deficiency results in liver damage, enlargement of the heart and neurologic alterations in the AD mice, typically accompanying Alzheimer's disease and including increased levels of plaque-forming amyloid-beta protein and disease-linked alterations in tau protein. Further, the study illustrates that choline deficiency in mice causes significant weight gain, alterations in glucose metabolism (which are tied to conditions such as diabetes), and deficits in motor skills. In the case of humans, “it's a twofold problem,” according to Ramon Velazquez, senior author of the study and assistant professor with the ASU-Banner Neurodegenerative Disease Research Center. “First, people don't reach the adequate daily intake of choline established by the Institute of Medicine in 1998. And secondly, there is vast literature showing that the recommended daily intake amounts are not optimal for brain-related functions.” The research highlights a constellation of physical and neurological changes linked to choline deficiency. Sufficient choline in the diet reduces levels of the amino acid homocysteine, which has been recognized as a neurotoxin contributing to neurodegeneration, and is important for mediating functions such as learning and memory through the production of acetylcholine. The growing awareness of choline's importance should encourage all adults to ensure proper choline intake. This is particularly true for those on plant-based diets, which may be low in naturally occurring choline, given that many foods high in choline are eggs, meats, and poultry. Plant-based, choline-rich foods, including soybeans, Brussels sprouts and certain nuts can help boost choline in these cases. Moreover, inexpensive, over-the-counter choline supplements are encouraged to promote overall health and guard the brain from the effects of neurodegeneration. The new study examines mice at 3-12 months, or early to late adulthood (roughly equivalent to 20-60 years of age for humans). In the case of both normal and transgenic mice displaying symptoms of Alzheimer's, those exposed to a choline-deficient diet exhibited weight gain and adverse effects to their metabolism. Damage to the liver was observed through tissue analysis, as was enlargement of the heart. Elevated soluble, oligomeric and insoluble amyloid-beta protein were detected, as well as modifications to tau protein characteristic of those leading to neurofibrillary tangles in the brain. Further, choline-deficient mice performed poorly in a test of motor skills, when compared with mice receiving adequate choline in their diet. These adverse effects were heightened in the transgenic mice. Translating these findings to humans, this implies that people who are predisposed to Alzheimer's disease or in the throes of the illness should ensure they are getting enough choline.”Our work provides further support that dietary choline should be consumed on a daily basis given the need throughout the body,” Velazquez says. (NEXT) Melanoma: Vitamin D supplements linked to reduced skin cancer risk University of Eastern Finland & Kuopio University, January 15, 2023 A new study finds that the regular use of vitamin D is associated with lower rates of melanoma skin cancer. The cross-sectional study was a collaboration between the University of Eastern Finland and Kuopio University Hospital. The research involved 498 Finnish adults determined by dermatologists to be at high risk of skin cancer, such as melanoma, as well as squamous cell carcinoma and basal cell carcinoma. According to researchers, people who took vitamin D regularly were less likely to have had melanoma in the past or currently and were deemed by dermatologists to be less likely to develop melanoma in the future. Study participants ranged in age from 21 to 79 years old, including 253 males and 245 females. Participants were divided into three groups based on their intake of vitamin D supplements: non-use, occasional use, or regular use. The researchers were also interested in finding out whether regular use of vitamin D supplements corresponded to higher blood levels of vitamin D, known as serum calcidiol or 25-hydroxy-vitamin D3. This is the “storage form” of vitamin D in the body. Some research has linked low serum calcidiol with increased cancer risk, while other research has suggested otherwise. Nonetheless, it is a measure often used to determine a person's vitamin D levels. After testing serum calcidiol levels in 260 participants, researchers found that regular vitamin D supplementation corresponded with the highest levels of serum calcidiol and non-supplementation with the lowest levels. “Human skin itself expresses [the enzyme] CYP27A1 that produces calcidiol from vitamin D, and CYP27B1 that produces biologically very active calcitriol from calcidiol,” Dr. Harvima explained, noting that enzyme expression determines the level of vitamin D and its metabolites in the body. (NEXT) New research furthers case for exercise promoting youthfulness University of Arkansas, January 17, 2023 A recent paper published in the Journal of Physiology deepened the case for the youthfulness-promoting effects of exercise on aging organisms, building on previous work done with lab mice nearing the end of their natural lifespan that had access to a weighted exercise wheel. For this paper, the researchers compared aging mice that had access to a weighted exercise wheel with mice that had undergone epigenetic reprogramming via the expression of Yamanaka factors. The Yamanaka factors are four protein transcription factors (identified as Oct3/4, Sox2, Klf4 and c-Myc, often abbreviated to OKSM) that can revert highly specified cells (such as a skin cell) back to a stem cell, which is a younger and more adaptable state. The Nobel Prize in Physiology or Medicine was awarded to Dr. Shinya Yamanaka for this discovery in 2012. In the correct dosages, inducing the Yamanaka factors throughout the body in rodents can ameliorate the hallmarks of aging by mimicking the adaptability that is common to more youthful cells. Of the four factors, Myc is induced by exercising skeletal muscle. Myc may serve as a naturally induced reprogramming stimulus in muscle, making it a useful point of comparison between cells that have been reprogrammed via over expression of the Yamanaka factors and cells that have been reprogrammed through exercise—”reprogramming” in the latter case reflecting how an environmental stimulus can alter the accessibility and expression of genes. Ultimately, the team determined that exercise promotes a molecular profile consistent with epigenetic partial programming. That is to say, exercise can mimic aspects of the molecular profile of muscles that have been exposed to Yamanaka factors (thus displaying molecular characteristics of more youthful cells). This beneficial effect of exercise may in part be attributed to the specific actions of Myc in muscle. Murach sees their research as further validation of exercise as a polypill. “Exercise is the most powerful drug we have,” he says, and should be considered a health-enhancing—and potentially life-extending—treatment along with medications and a healthy diet. (NEXT) Exploiting the synergy of nutraceuticals for cancer prevention and treatment Research suggests that free radicals (ROS) generated upon mixing two nutraceuticals—resveratrol and copper—can help ameliorate various diseases by inactivating cell-free chromatin particles Tata Memorial Centre (India), January 16, 2023 Chromatin comprises a complex mixture of DNA and proteins that forms the structural basis of chromosomes in the cellular nuclei. When cells die, they release cell-free chromatin particles or “cfChPs” into the circulatory system. In 1996, evidence for tumour-derived DNA circulating in the blood of cancer patients was first reported. This evidence caught the interest Dr. Indraneel Mittra, who is now Professor Emeritus and the Dr. Ernest Borges Chair in Translational Research at Tata Memorial Centre in Mumbai, India. His tryst with research on genetic material in cancer metastases began, and after 15 years of research he has presented various papers, developing a body of evidence that indicates the critical role of cfChPs in orchestrating development of not only cancer, but various other diseases. Emerging evidence indicates that cfChPs play an essential role in ageing, sepsis, cancer development, and chemotherapy-related toxicity. With respect to the latter, Prof. Mittra explains, “Chemo-toxicity is not primarily caused by chemotherapeutic drugs, but rather by cfChPs that are released from the first cells that die after chemotherapy. The released cfChPs set in motion a cascading effect, increasingly damaging the DNA of healthy host cells, and triggering inflammatory processes in a vicious cycle that perpetuates and prolongs the toxicity of chemotherapy.” Recently, a team from Tata Memorial Centre have demonstrated the therapeutic benefits of a pro-oxidant mixture of resveratrol and copper, R-Cu, in patients undergoing chemotherapy for advanced gastric cancer. Combining R with Cu (R-Cu) leads to the generation of free oxygen radicals which can inactivate the offending cfChPs. In this context, the research team launched a single-arm phase II clinical trial to study the synergistic effects of R-Cu administration on cfChPs inactivation in patients with advanced gastric cancer. The primary objective was to determine whether R-Cu, via cfChPs' inactivation, was successful in reducing the grade ≥ 3 toxicity seen with docetaxel-based chemotherapies. To this end, the researchers monitored the likely changes in the toxicities of chemotherapeutic treatments using a grading system that provides a framework for the assessment of unwanted physiological effects. The results were promising—although R-Cu did not reduce haematological toxicities, it significantly reduced the incidence of non-haematological toxicities comprising hand-foot syndrome, diarrhoea, and vomiting. Moreover, R-Cu reduced docetaxel exposure compared to the control arm without affecting efficacy in terms of overall survival. (NEXT) Deep meditation may alter gut microbes for better health Shanghai Jiao Tong University School of Medicine (China), January 16, 2023 Regular deep meditation, practiced for several years, may help to regulate the gut microbiome and potentially lower the risks of physical and mental ill health, finds a small comparative study published in the open access journal General Psychiatry. The gut microbes found in a group of Tibetan Buddhist monks differed substantially from those of their secular neighbors, and have been linked to a lower risk of anxiety, depression, and cardiovascular disease. Research shows that the gut microbiome can affect mood and behavior through the gut–brain axis. This includes the body's immune response, hormonal signaling, stress response and the vagus nerve—the main component of the parasympathetic nervous system, which oversees an array of crucial bodily functions. The significance of the group and specimen design is that these deep-thinking Tibetan monks can serve as representatives of some deeper meditations. Although the number of samples is small, they are rare because of their geographical location. The researchers analyzed the stool and blood samples of 37 Tibetan Buddhist monks from three temples and 19 secular residents in the neighboring areas. None of the participants had used agents that can alter the volume and diversity of gut microbes: antibiotics; probiotics; prebiotics; or antifungal drugs in the preceding 3 months. Sample analysis revealed significant differences in the diversity and volume of microbes between the monks and their neighbors.”Collectively, several bacteria enriched in the meditation group [have been] associated with the alleviation of mental illness, suggesting that meditation can influence certain bacteria that may have a role in mental health,” write the researchers. These include Prevotella, Bacteroidetes, Megamonas and Faecalibacterium species, the previously published research suggests. Finally, blood sample analysis showed that levels of agents associated with a heightened risk of cardiovascular disease, including total cholesterol and apolipoprotein B, were significantly lower in the monks than in their secular neighbors by their functional analysis with the gut microbes. (NEXT) Curcumin/Boswellia shows promise in chronic kidney disease Baylor University, January 14, 2023. The Journal of Complementary and Integrative Medicine reports the finding of researchers at Baylor University of a reduction in a marker of inflammation among chronic kidney disease patients given a combination of Curcuma longa (curcumin) and Boswellia serrata. The study included sixteen individuals receiving standard care for chronic kidney disease who were not undergoing dialysis. Participants were randomized to receive capsules containing curcumin from turmeric extract plus Boswellia serrata, or a placebo for eight weeks. Blood samples collected before and after treatment were analyzed for plasma interleukin-6 (IL-6), tumor necrosis factor alpha (markers of inflammation), and the endogenous antioxidant enzyme glutathione peroxidase, as well as serum C-reactive protein (CRP, another marker of inflammation.) Blood test results from the beginning of the study revealed increased inflammation and reduced glutathione peroxide levels. At the study's conclusion, participants who received curcumin and Boswellia serrata experienced a reduction in interleukin-6 in comparison with pretreatment values, indicating decreased inflammation, while IL-6 values rose among those who received a placebo. In their discussion of the findings, the authors remark that curcumin and Boswellia serrata have been separately shown to lower interleukin-6 via inhibition of the nuclear factor kappa beta and mitogen activated protein kinase (MAPK) signaling pathways.

Please Subscribe and Review: Apple Podcasts | RSS Submit your questions for the podcast here News topic du jour: The corporate capture of the nutrition profession in the USA: the case of the Academy of Nutrition and Dietetics Podcast Questions: 1. Fermentation [12:51] Ken says: I bought your book back in 2010, it was my first dive into evolutionary medicine, etc. I've been listening to your podcast since. I'm 44, 203 as of this morning, and still competing in the Scottish highland games and playing Rugby. In 2011 I was tested for auto-nuclear antibodies and was on the cutoff. The thought then was celiac disease but there was never a colonoscopy follow-up, as the doctor never called me from the referral, and eating paleo made me feel better so I just ran with it. A couple of years later my TSH was low and instead of taking Synthroid, I did a bout of AIP and didn't notice anything then, but my TSH went up. A few years later we found a Baker's cyst in my knee, did AIP again, and found that alcohol was a trigger. Doing different things to address my gut health, which was always an issue, and was always an issue for my dad who had Crohn's disease, I found that not only was alcohol a trigger. so was anything fermented, including kombucha, kimchi, sauerkraut, and soft cheeses, everything after about 3 days of daily consumption would make me sick. So I guess my first question is, have you ever heard of anything like that before? In January I am scheduled to have a hemorrhoidectomy and was told by the doctor as usual to increase fiber. Since I still have issues with a loose stool I figured I'd give it a shot. I also bought Dr. Cait Shanahan's book, "Deep Nutrition" and started to implement the four pillars and a psyllium husk fiber. To my surprise, I started getting sick again, the way I would to prolonged exposure to fermentation. With that I ask, is the fermentation of fiber in my digestive tract making me sick? Another, have you ever heard of that? Right now I only see carnivore as an option. Is there a possible door I can check for a way to fix my digestive tract enough that any type of fiber doesn't affect me? And how far does this go? Am I destined to only drink water, is there any fiber in coffee? Do I need to switch my LMNT order to only raw, unflavored? Willing to turn over stones and look, just don't see anymore. A high-fiber diet synergizes with Prevotella copri and exacerbates rheumatoid arthritis 2. Muscle Loss [32:40] John says: Hi Gang, What are the major contributors for muscle loss as we age? I am a diabetic, 61 years old and have lost significant muscle and continue to do so. Doctor's don't have any answers other than I am older and diabetic. So how do you stop or slow down and even better, reverse this process? Love all your stuff and don't want to leave out the wife here. We know she is great too. Longtime listener, John 3. Whey Isolate [38:49] Jody says: Hi Robb and Nikki! Thanks for continuing to do the podcast, great information and very entertaining! I love your humour and your no nonsense approach. My question is about whey protein. I have autoimmune disease and I avoid gluten and dairy, other than ghee which I tolerate well. I'm an avid lifter and I do some running and yoga as well. Sometimes I find it hard to hit my protein targets but I don't want to over do the legumes or grains by using a plant based protein powder. From what I can find, it seems that casein is more immunoreactive than whey. I'm wondering if I should try a very clean whey isolate or if dairy is just a bad idea in general. Thoughts? Sponsor: The Healthy Rebellion Radio is sponsored by our electrolyte company, LMNT. Proper hydration is more than just drinking water. You need electrolytes too! Check out The Healthy Rebellion Radio sponsor LMNT for grab-and-go electrolyte packets to keep you at your peak! They give you all the electrolytes want, none of the stuff you don't. Click here to get your LMNT electrolytes Transcript: You can find the transcript for this episode on the blog page at https://robbwolf.com/2023/01/06/fermentation-preventing-muscle-loss-whey-isolate-thrr137/

A recent study has shown that methimazole supplemented with berberine can improve therapeutic effects for people with Graves' disease.Does that mean those with Graves' disease could benefit from berberine on its own as an agent that improves the gut microbiome? Based on this study, the answer seems to be yes.Today I'm diving into this journal article, sharing the details of the study itself and my key takeaways for those with Graves' disease.In this episode, you'll learn:How this study was designedWhich markers were being measured in the studyThe difference observed between the use of berberine with methimazole versus methimazole aloneBenefits of berberine for gut healthEvidence that intestinal microbes can contribute to the development of thyroid diseaseThe possible connection between Graves' disease and Prevotella spp.As always, I hope you found this episode valuable, and I look forward to catching you in the next episode!To learn more, visit the show notes at https://savemythyroid.com/podcast/can-berberine-increase-the-effectiveness-of-methimazole/.Do You Want Help Saving Your Thyroid? Access hundreds of free articles at www.NaturalEndocrineSolutions.com Visit Dr. Eric's YouTube channel at www.youtube.com/c/NaturalThyroidDoctor/ To work with Dr. Eric, visit https://savemythyroid.com/work-with-dr-eric/

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com. Highlighted discussion of implantable stimulators, urine proteomics and gut-immune responses to Prevotella in RA.

Gut bacteria can cause, predict and prevent rheumatoid arthritis Mayo Clinic  July 9, 2022   The bacteria in your gut do more than break down your food. They also can predict susceptibility to rheumatoid arthritis, suggests Veena Taneja, Ph.D., an immunologist at Mayo Clinic's Center   Dr. Taneja and her team identified intestinal bacteria as a possible cause; their studies indicate that testing for specific microbiota in the gut can help physicians predict and prevent the onset of rheumatoid arthritis. "These are exciting discoveries that we may be able to use to personalize treatment for patients," Dr. Taneja says.   "Using genomic sequencing technology, we were able to pin down some gut microbes that were normally rare and of low abundance in healthy individuals, but expanded in patients with rheumatoid arthritis," Dr. Taneja says.   The second paper, published in Arthritis and Rheumatology, explored another facet of gut bacteria. Dr. Taneja treated one group of arthritis-susceptible mice with a bacterium, Prevotella histicola, and compared that to a group that had no treatment. The study found that mice treated with the bacterium had decreased symptom frequency and severity, and fewer inflammatory conditions associated with rheumatoid arthritis. The treatment produced fewer side effects, such as weight gain and villous atrophy—a condition that prevents the gut from absorbing nutrients—that may be linked with other, more traditional treatments.   While human trials have not yet taken place, the mice's immune systems and arthritis mimic humans, and shows promise for similar, positive effects. Since this bacterium is a part of healthy human gut, treatment is less likely to have side effects, says study co-author Joseph Murray, M.D., a Mayo Clinic gastroenterologist.         Adding salt to your food at the table is linked to higher risk of premature death Tulane University School of Public Health, July 11, 2022   People who add extra salt to their food at the table are at higher risk of dying prematurely from any cause, according to a study of more than 500,000 people, published in the European Heart Journal today. Compared to those who never or rarely added salt, those who always added salt to their food had a 28% increased risk of dying prematurely. In the general population about three in every hundred people aged between 40 and 69 die prematurely. The increased risk from always adding salt to food seen in the current study suggests that one more person in every hundred may die prematurely in this age group. In addition, the study found a lower life expectancy among people who always added salt compared to those who never, or rarely added salt. At the age of 50, 1.5 years and 2.28 years were knocked off the life expectancy of women and men, respectively, who always added salt to their food compared to those who never, or rarely, did. "To my knowledge, our study is the first to assess the relation between adding salt to foods and premature death," he said. "It provides novel evidence to support recommendations to modify eating behaviors for improving health. Even a modest reduction in sodium intake, by adding less or no salt to food at the table, is likely to result in substantial health benefits, especially when it is achieved in the general population."   Hops extract studied to prevent breast cancer University of Illinois  July 8, 2022    An enriched hops extract activates a chemical pathway in cells that could help prevent breast cancer, according to new laboratory findings from the Center for Botanical Dietary Supplements Research at the University of Illinois at Chicago.   Researchers led by Judy Bolton, professor and head of medicinal chemistry, applied hops extract to two different breast cell lines to see if they would affect estrogen metabolism, a key mechanism in breast cancer. One compound, 6-prenylnarigenin, or 6-PN, increased a detoxification pathway in the cells that has been linked to a lower risk for breast cancer.   "We need to further explore this possibility, but our results suggest that 6-PN could have anti-cancer effects," Bolton said.       New study determines psychedelic mushroom microdoses can improve mood, mental health University of British Columbia, July 11, 2022   The latest study to examine how tiny amounts of psychedelics can impact mental health provides further evidence of the therapeutic potential of microdosing. Published in Scientific Reports, the study followed 953 people taking regular small amounts of psilocybin and a second group of 180 people who were not microdosing. For the 30-day study, those microdosing demonstrated greater improvements in mood, mental health and psychomotor ability over the one-month period, compared to non-microdosing peers who completed the same assessments. "This is the largest longitudinal study of this kind to date of microdosing psilocybin, and one of the few studies to engage a control group," says Dr. Walsh, who teaches in the Irving K. Barber Faculty of Arts and Social Sciences. "Our findings of improved mood and reduced symptoms of depression, anxiety and stress add to the growing conversation about the therapeutic potential of microdosing." Microdosing involves regular self-administration in doses small enough to not impair normal cognitive functioning. The doses can be as small as 0.1 to 0.3 grams of dried mushrooms, and may be taken three to five times a week. The most widely reported substances used for microdosing are psilocybin mushrooms and LSD. Psilocybin mushrooms are considered non-addictive and non-toxic—especially when compared to tobacco, opioids and alcohol.    Could a phytochemical derived from vegetables like broccoli be the answer to antibiotic resistant pathogens?   Ben-Gurion University of the Negev (Israel), July 10, 2022  Antibiotic resistant bacterial pathogens are increasingly playing a role in rising illness and preventing wound healing, especially in hospitals. While more and more pathogens have developed biofilms that protect them from being eradicated by antibiotics, fewer classes of antibiotics are being developed. Researchers from Ben-Gurion University of the Negev decided to go in a different direction and investigated a phytochemical derived from cruciferous vegetables such as broccoli that breaks down the biofilm. The phytochemical 3,3'-diindolylmethane (DIM) successfully broke down the biofilms protecting two different pathogens including Acinetobacter baumannii and Pseudomonas aeruginosa– enabling their eradication 65% and 70% of the time, respectively. Combined with antibiotics, that number jumped to 94%. Additionally, when they introduced DIM into an infected wound, it sped up the healing process significantly, the team found.     Researchers find Alzheimer's begins in the brain 30 years before any symptoms  Daniel Amen Clinic July 9, 2022   Science is beginning to unravel the mystery of Alzheimer's disease and what they are discovering is alarming.  Researchers now believe that Alzheimer's disease begins with changes in the brain as much as 30 years or more before symptoms begin.   This shocking revelation comes at a time when the aging of the Baby Boomer generation means Alzheimer's is expected to triple in the coming decades. Long before someone is diagnosed in their 70s or 80s, their brain has begun to deteriorate. With conventional medicine unable to offer a cure, this realization makes it all the more critical to care for brain health throughout your lifetime, naturally reducing the risk of Alzheimer's and other forms of dementia. The idea that a fading memory is just a natural part of the aging process is a misconception.  Instead, loss of memory is a sign of the brain beginning to break down.   In addition to a diagnosis for ADD, other factors he believes can increase the risk of developing the disease include:   • Failure to engage the brain in regular learning activities • Lack of exercise or exercising less than twice a week • Personal medical history of cancer, diabetes or heart disease • Suffering of a stroke • Coping with a head injury • Diagnosis of depression Along with understanding your risk level, Dr. Amen advocates keeping both mind and body active. Dr. Amen also believes it is important to increase antioxidant levels in your diet. He also tells patients it is important to modify lifestyle habits that promote the growth of brain plaques.

CM (Cynthia) Monteleone is a World Champion in the 400m, a mom of 3, and author and a Metabolic Analytics Practitioner. It was no coincidence that when Cynthia decided to become the best in the world, she chose Charles Poliquin to study under. Her mentor shared his knowledge and encouraged her to keep up the fire for learning and achieving. Cynthia gets tremendous results because of her passion: which is to help others thrive. MAM Maui Metabolics grew out of this mission to encourage others to become their own superhero warrior self.  When winning the gold, she ran faster at age 43 then she did as a Division I collegiate track athlete! She attributes this to learning how to alter epigenetics to favor delayed aging, healthy biomarkers and exceptional athletic performance. After listening to and consulting on hundreds of client cases, (everyone from Olympians to the neighbor next door)  she is adept at reading patterns and using her knowledge and experience to solve health and performance puzzles with easy protocols. She lives in Maui with her husband and 3 children.   GET THE MEAT! http://NosetoTail.org GET THE FREE SAPIEN FOOD GUIDE! http://Sapien.org   SHOW NOTES [5:10] Her background and education. [13:40] Her mission with her clients.  [16:25] Using carbs over fat for exercise performance. [26:10] Endurance training, gastrointestinal stress and overtraining.  [32:40] Running barefoot and the benefits of sprinting.  [39:40] Issues with plant based diets. Presence of Bacteria in Spontaneous Achilles Tendon Ruptures  Chronic inflammation is a feature of Achilles tendinopathy and rupture  [43:40] Prevotella bacteria from carbohydrate consumption.  COVID-2019-associated overexpressed Prevotella proteins mediated host-pathogen interactions and their role in coronavirus outbreak  Gut microbiota and Covid-19- possible link and implications  [46:40] Injuries and plant based diets. [48:50] Red meat and hormone balance.  [55:20] The negative connotation of red meat.  [59:40] Introduction to Margaret, Cynthia's daughter.  [1:18:10] Protein shake trick for mood swings. [1:20:30] Her blood work and her doctor's opinion on it.   GET THE MEAT! http://NosetoTail.org GET THE FREE SAPIEN FOOD GUIDE! http://Sapien.org   Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg  

The connection between alcohol and gut health is established in scientific literature: alcohol is an inflammatory agent. But as researchers like Vincent Maffei work to improve the quality of life for HIV patients, every bit of information of how that inflammation develops makes a difference, especially in how alcohol and bowel problems connect.  Listeners will learn The difference between chronological and biological health and how HIV patients experience increased biological aging, The connection between alcohol and G.I. issues, particularly less diverse microbiota, and The significance of their findings, specifically the abundance of Prevotella spp., a bacteria that may be a mediator between alcohol and cell senescence.  Vincent J. Maffei is with the Department of Microbiology, Immunology, and Parasitology at LSU. As a graduate student, he became involved in LSU's Comprehensive Alcohol Research Center (CARC) and studied how dysbiosis accompanies biological aging. He combined this with studying how alcohol affects the intestines, and now studies this specifically with HIV patients. More specifically, he works to find associations between alcohol use and advancing aging in HIV patients and their guts. He explains to listeners about several players in this complex mix of cause and effect: alcohol and gut health as well as alcohol and HIV patients. He establishes that any amount of alcohol can be harmful to someone suffering from HIV. Combine that with an already-established connection with alcohol and dysbiosis in the gut, and researchers are faced with a very real problem to solve for these patients. He does a careful job explaining the background to listeners, bringing in other studies more general to alcohol use and explaining its effect on T-cell senescence, which basically means they lack the ability to copy themselves—limiting their ability to fight infection. Senescence is also a characteristic of biological aging. He explains that the administration of alcohol breaks down the gut barrier, allowing microbes to migrate from the lumen of gut into tissue, which causes inflammation. He also explains their worthy end goal: to identify some sort of microbiota intervention to relieve this component of inflammation in HIV patients, improving their life span and quality of life. Hopefully their findings will lead to more precise mechanisms that can be leveraged in therapeutic modality.   For more, see the CARC website: medschool.lsuhsc.edu/alcoholresearch. Available on Apple Podcasts: apple.co/2Os0myK

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.25.266122v1?rss=1 Authors: Kohn, N., Szopinska-Tokov, J., Llera Arenas, A., Beckmann, C. F., Arias-Vasquez, A., Aarts, E. Abstract: Research on the gut-brain axis has accelerated substantially over the course of the last years. Many reviews have outlined the important implications of understanding the relation of the gut microbiota with human brain function and behavior. One substantial drawback in integrating gut microbiome and brain data is the lack of integrative multivariate approaches that enable capturing variance in both modalities simultaneously. To address this issue, we applied a linked independent component analysis (LICA) to microbiota and brain connectivity data. We analyzed data from 58 healthy females (mean age=21.5 years). Magnetic Resonance Imaging data were acquired using resting state functional imaging data. The assessment of gut microbial composition from feces was based on sequencing of the V4 16S rRNA gene region. We used the LICA model to simultaneously factorize the subjects' large-scale brain networks and microbiome relative abundance data into 10 independent components of spatial and abundance variation. LICA decomposition resulted in four components with non-marginal contribution of the microbiota data. The default mode network featured strongly in three components, whereas the two-lateralized fronto-parietal attention networks contributed to one component. The executive-control (with the default mode) network was associated to another component. We found the abundance of Prevotella genus was associated to the strength of expression of all networks, whereas Bifidobacterium was associated with the default mode and frontoparietal-attention networks. We provide the first exploratory evidence for multivariate associative patterns between the gut microbiota and brain network connectivity in healthy humans, taking into account the complexity of both systems. Copy rights belong to original authors. Visit the link for more info

This is part 2 (a continuation of last week's Eczema Podcast episode), where Dr. Kelly Blodgett shared how hidden dental issues (such as hidden gum disease, root canals, implants, dental meridians, gum grafts, cavities and silver amalgam fillings) can affect your skin, dermatitis, and other parts of the body (research paper links are listed below). Dental issues are often overlooked. Today's guest is Dr. Kelly Blodgett, a biological and naturopathic dentist. Dr. Kelly Blodgett graduated from the American College of Integrative Medicine and Dentistry and has a Board Certification in Naturopathic Dentistry and a Board Certification in Integrative Biological Dental Medicine. (You can find Dr. Kelly Blodgett's website here: https://www.blodgettdentalcare.com. He also offers online consultations as well.) The American Academy of Periodontology also shares on their website that periodontal (gum) disease is associated with several other diseases, such as diabetes, alzheimer's, and heart disease.   Like the other microbiomes of the body (gut and skin), the oral microbiome is a collection of bacteria that affects the progression of health and disease. A major 2019 study in the Journal of Oral Microbiology discovered that bacterial populations from the mouth make their way to the gut microbiota. Just as there's leaky gut, there can also be leaky mouth as well. This can alter immune responses and potentially lead to systemic diseases. Infants who have eczema are also 3 times more likely to develop tooth decay when they are 2 and 3 years old, according to this study from the National University of Singapore (NUS) Faculty of Dentistry and the Singapore Institute for Clinical Sciences. Cass Nelson-Dooley, MS, an ethnopharmacologist, also shared in her research that 45% of the bacteria in the mouth are also found in the gut. Oral infection can cause major issues within the rest of the body in a variety of ways. Bacteria can escape through the gums to the bloodstream, cause system-wide inflammation, and bacterial toxins that make their way throughout the body. Two of the major bacterial groups in the oral biome that can impact the rest of health most notably include Prevotella and Veillonella. Research has also shown that dental infection has been linked to nummular eczema as well. Below are case studies of how dental issues & infections can affect atopic dermatitis and eczema: https://www.sciencedirect.com/science/article/abs/pii/0030422060904904 https://www.ncbi.nlm.nih.gov/pubmed/19691752 - (Nummular eczema linked to dental infection) https://www.ncbi.nlm.nih.gov/pubmed/16924154 https://www.ncbi.nlm.nih.gov/pubmed/17442076 http://www.jacionline.org/article/S0091-6749(16)31456-7/fulltext https://www.drkarafitzgerald.com/wp-content/uploads/2015/06/2015-Oral-Microbiome-Nelson-Dooley-Olmstead.pdf https://pubmed.ncbi.nlm.nih.gov/28637979/ https://www.perio.org/consumer/gum-disease-and-other-diseases     >> For more eczema tips, follow Abby on: Facebook - facebook.com/eczemaconquerors Instagram - instagram.com/eczemaconquerors YouTube -  youtube.com/user/eczemaconquerors Website - eczemaconquerors.com Want more eczema resources?  Shop my Conqueror line of products to help your skin find relief here: https://store.primephysiquenutrition.com/collections/all *Use the code PODCAST10 for 10% off your order here.

Welcome to the Whole View, episode 406. (0:27) Stacy is so jazzed about this show. Sarah and Stacy have been talking about it and preparing for it since this show was called the Whole View. Stacy personally is jazz hands about educating a dear loved one on why filtering water is a good idea. To kick things off, Stacy is going to share a little story from their trip last summer. While on the road, Stacy saw what she thought was a fresh spring and encouraged the boys to fill their water bottles. Stacy basically gave her kids dysentery. This is Stacy's story about why water filtration is important. Stacy ran a poll last week and only 21% were on team Stacy and thought it was a harmless stream. What Stacy thinks is fascinating is that it is not just runoff water that is not good for you. Oftentimes our municipal water is not meeting the standards. It is important to understand that, and beyond that, it is important to know what you should be aware of when it comes to water. Sarah has so much science.   This Week's Sponsor But first, Stacy wants to take a moment to thank this week's sponsor, AquaTru. (4:27) Their reverse osmosis system has been sitting on Stacy's counter for a month now, but there is one person in the house who is not convinced that it is a good idea. Stacy first loved this system because of the information that Sarah shared, but second loved that it is endorsed by Erin Brockovich. Sarah has had an AquaTru for over four years, and what she loves about them is how different their technology is. It’s the only counter-top reverse osmosis system —  in a category all its own. It is not bottled water, not a fridge filter pitcher like Brita or Pur, and is not an under the counter or whole house system needing installation. AquaTru is the only purifier to remove the ‘forever chemicals’ known as PFOAs and at the center of the movie Dark Waters. Most reverse osmosis (RO) systems waste four gallons of water for every one gallon they produce. AquaTru uses a patented water conservation technology that is about 12x more efficient than professionally installed under-the-sink RO systems. RO is the best way to filter water. They are giving our podcast listeners $150 off their AquaTru purchase.   Listener Question Jessica says, "new podcast name! Love it! (10:44) Thanks for continuing to podcast. Crazy times in the world and you and Sarah’s voice is so utterly comforting. Anyway, podcast question! Water intake. I don’t think you guys have done a, 'how much water do we need', podcast episode. A deep dive into this would be really helpful. The standard advice seems to be either one amount for men and one amount for women, or, half your body weight in oz.  Which is correct? Or is there another answer? What about just drinking when thirsty? I also have wondered, how much water did our ancestors drink? I assume the water was maybe harder to come by back then so maybe they were drinking less? This is the assumption I’ve always made and has led to me drinking intuitively, which has more than likely led to me being chronically dehydrated :) I feel like with all the conflicting info, it would be great to hear the science.  By the way Stacy, as a side note, after about a year I finished catching up on the podcast. I know you are sorry, I am not ;). When searching for a water-related episode, I and came upon an episode called Thirsty Brain. I was like, for sure this has to be about how water intake affects our brain. Nope. Lol. But that was a great episode about Matt’s podcast, called Thirsty Brain :) love you guys.   Thanks again for all you do!"   How Much Let's start with how much water. (14:15) This has been a debated topic within the medical and scientific community. The classic 8, 8 oz. glasses a day is actually not enough. However, this original recommendation was based on how much water we lose over the course of a day and was not based on how much we actually need. The question now is, how much water makes us healthy? The latest research suggests that men should consume about 13 cups (104 ounces, or 3 liters) of fluid per day, and women should consume about 9 cups (74 ounces, or 2.2 liters). The reason it is different between men and women is basically a reflection of body size and BMR. This amount is not pure water intake. It includes the water that we get from all sources, factoring in all beverages, and the water we get from food. From there, our needs would shift up if we are highly active, if it is hot out, certain dietary needs, etc. Sarah thought the hunter-gather aspect of Jessica's question was very interesting. So she spent some time trying to track that information down. However, she couldn't find a good estimate. That being said, Sarah did find a really interesting paper looking at human evolution. We only find remains of early humans near water sources, and so we know that early humans tended to congregate near water. Communities were and still are centered around ways of getting water. There has been some anthropological research showing that this might have been very important in human evolution. Our brains use a lot of energy, which creates a lot of metabolic byproducts, which have to be filtered by the liver and kidneys, which increases our need for water to make urine to effectively detoxify. So our ability to grow these awesome brains would have relied on proper hydration, in addition to high-quality food. We can't say how many ounces of water hunter-gathers consumed on average, but we can say that it was very likely that they drank a lot of water and likely drank intuitively.   Intuitive Hydration Studies looking at hydration have been really interesting. (19:56) Overall they show that humans in general as a species are pretty good at drinking intuitively. Studies have come at this from a bunch of different ways, where they have looked at what happens when you have given people free access to water and you measure how much water they drink? In general, people are really good at staying hydrated, provided water is around. On average people will drink about two liters of water per day, just driven by thirst. Which is probably the right amount of water, considering other beverages and water from food sources. There have been studies showing that this is true in different populations. Athletes' performance is best when they just follow their thirst for drinking. 'Follow your thirst' does seem to work best for performance. However, there are a variety of things that have been shown to reduce our thirst relative to our water needs. Which basically means you are not thirsty enough for how much water you need. These people need to focus more on hydration and drink with intention, versus just following thirst. There are a bunch of drugs that are used for cardiovascular disease that impact thirst. Elderly people also tend to end up dehydrated and are do not have strong enough thirst signals for their water needs. Menopause causes this is women and high estrogen in general. Swimming can actually reduce our thirst. Exercising in the heat can also impact our thirst awareness. When Sarah looks at this list this means that there are so many exceptions that overall it is a pretty good idea to at least be mindful of hydration. There are bad things that happen when we don't drink enough water on a regular basis. Stacy shared her experience with her lack of thirst and dehydration.   What Happens if you Don't Drink Enough? What is interesting is that acute dehydration will make you feel extremely ill, but chronic-mild dehydration kind of creeps up on you in terms of the symptoms. (27:03) Like so many chronic things, the human body is remarkable in terms of how it adapts to not feeling good. You can end up not noticing for a while. There has been a huge variety of studies showing that even mild dehydration puts a strain on the kidneys, which can cause high blood pressure, reduced energy, fatigue, constipation, dry skin, and more. What is interesting to Sarah is the number of cognitive issues associated with mild dehydration. It can cause frequent headaches, impair mood, increase anxiety, reduce concentration, impair memory, reduce cognitive performance and it also has a pretty measurable impact on exercise performance. The thing that nerds Sarah out is that our microbiome is sensitive to our hydration status. This is because we have this whole collection of bacterial species that actually live in or attached to the mucus barrier. Sarah explained the mucus layer in greater detail. This is why inadequate hydration can cause constipation. What happens when we are not drinking enough, that the mucus layer gets harder and less viscus. This makes it a less hospitable environment for really important probiotic bacteria. It also makes it a more hospitable environment for pathogens. This has been confirmed in some really interesting animal studies. Acute hydration would include feeling dizzy, rapid heartbeat, rapid breathing, extreme fatigue and sleepiness, confusion, and irritability and it can cause things like fainting. You would see severe dehydration in having UTIs, kidney infections, and kidney stones.   Alkaline Water Sarah feels that alkaline water is one of the biggest scams in the health community. (34:48) Alkaline water has an alkaline pH. Commercial alkaline water typically has a pH of 8.8 or higher with high dissolved mineral content, typically calcium, potassium, and magnesium. Alkaline water is known to neutralize stomach acid, which on the surface may sound like an awesome thing for anyone who suffers from acid reflux. However, because the acidity of chyme is a key signal to the pancreas to secrete digestive enzymes and to the gallbladder to secrete bile, neutralizing stomach acid can hinder digestion in a big way! So anything that neutralizes stomach acid actually hinders digestion, which can cause a whole pile of problems. The other thing is the impact on the gut microbiome. If you are neutralizing those acidic molecules with alkaline water, you are actually suppressing the growth of really key probiotic species and increasing the growth of potential pathogens. Studies confirm that drinking alkaline water causes an undesirable shift in gut microbiome composition. One study in mice showed that drinking alkaline water for 4 weeks caused a huge decrease in probiotic Clostridiumspecies with smaller decreases in Bifidobacterium and Lactobacillus, and a rise in Prevotella. A randomized, controlled cross-over intervention in adult men compared the impact on the gut microbiome of consuming 2 liters per day of alkaline water (pH 9) compared to neutral water (pH 7) for two weeks. While the alkaline water had no effect on overall species diversity or richness, the men benefited from higher hydration levels from neutral pH water, which significantly increased richness by 15% when comparing pre- and post-intervention samples. The benefits of alkaline water that have been measured are probably completed attributed to the fact that many of us are not getting enough calcium or potassium. So we can benefit from getting these in their elemental form dissolved into water.   Spring Water Spring/mineral waters can be slightly acidic. (38:50) Most natural sources of mineral water in the world are acidic, not alkaline. Acidic water, because our gut bacteria love living in an acidic environment, has been shown to improve the gut microbiome to reduce a diabetes-associated microbiome. It also improves the growth of probiotic species, at least in animal studies. So it is much more important to look for mineral water or to add mineral drops to your water. Sarah adds mineral drops to her water before she drinks it. There is definitely benefit to mineral content, but that alkaline water is not doing your gut any favors. Stacy has experienced this with the digestive piece before.   Tap Water The water that comes out of our taps originates from lakes, rivers, and or groundwater. (41:37) Then it goes under extensive filtration and then disinfection. Disinfection uses one of two chemicals - chlorine or chloramine. It is important for safety to go through this disinfection process. When you think about the community of microbes that live in our gut and think about a disinfectant being added to our water, you think about the impact this has on your gut bacteria. Studies have shown that they absolutely do. The chlorine/chloramine that is added to drinking water not only decreases the growth of really important probiotic species, but it actually allows the growth of multi-resistant pathogens. There have been a variety of studies showing that feeding animals chlorinated tap water actually increases the number of bacteria that are growing in their digestive tract. These bacteria strains are associated with hospital inquired infections. Studies have shown that there is a potential link between chlorinated drinking water and the incidence of colorectal cancer. To understand whether this effect is mediated via the microbiome, a study compared the effect of drinking chlorinated water versus tap water in transgenic mice susceptible to colon cancer. Chlorinated water causes a substantial increase in tumor development in the colon, associated with reduced levels of Clostridium perfringens, a species believed to have anti-tumor effects. Interestingly, mice drinking tap water tended instead to develop tumors in the small intestine. Removing the chlorine/chloramine after the water comes out of our tap before we drink it, is a really good idea for our gut microbiome.   More on Fluoride There are also a lot of municipalities in North America that add fluoride to tap water, with the rationale of reducing tooth decay. In episode 34 Stacy and Sarah discussed fluoride, and the science has not changed. The science showing that fluoride is beneficial for dental health when it makes prolonged contact with tooth surfaces is really strong. However, the science showing any benefit to oral health from drinking fluoridated water is basically nonexistent. There have been some really large studies showing that fluoridation does not increase the risk of anything of the things that have been rumored to be true. However, there have been a few studies showing a correlation between fluoride levels and lower IQ in children. This has opened up the question if fluoride can open up the blood-brain barrier, and potentially negatively impact early brain development. But this is still a big open question where more science is needed. We do know that fluoride seems to accumulate in the pineal gland as we age.  The pineal gland is located in our brain and secretes melatonin to help us sleep. We don't know if this is what is behind sleep disturbances, but its something to point to that shows how fluoride crosses the blood-brain barrier. Overall, more research is needed to clarify if there are actual risks with fluoridation. We do know that the benefits are not measurable. In a study of broiler chickens, high levels of dietary fluorine resulted in lower microbial diversity, significantly lower levels of Lactobacillus and Bifidobacterium species. The study also showed significantly higher levels of Escherichia coli and Enterococcus compared to the control group. In a mouse study, 12 weeks of exposure to fluoride altered the oral microbial community by selectively depleting probiotic Parabacteroides distasonis, Bacteroides uniformis, and an unclassified Bacteroides species. However, if we are using fluoridated toothpaste, drinking non-fluoridated water appears to pose no risk to oral health. There is a strong case for filtering water for removing chlorine, chloramine, and fluoride. Stacy isn't yet adding minerals to her water but is going to give it a try and is excited. You can get those minerals on the AquaTru.   Pesticide Residues in Tap Water While an inexpensive activated carbon (charcoal) water filter can remove chlorine, chloramine, and fluoride from tap water. Unfortunately, these common water filtration systems can’t remove pesticide residues. Heavy metals are a well-known problem. (53:57) If you have lead in your tap water there is so much information out there that you would understand the importance of not showering in this level of contaminated water. We talked about how glyphosate impacts the gut microbiome in last week’s episode (405). Glyphosate exposure increases the ratio of pathogenic bacteria to probiotic microbes, reducing Bifidobacteria, Lactobacillus, and Enterococcus while increasing Salmonella and Clostridium. There is no dose-response. Any glyphosate exposure is problematic. In the US, glyphosate has been used for over 40 years and is used mostly to kill weeds that interfere with agricultural crops (typically corn, soy, and canola). We know that runoff from industrial agriculture is a major source of contaminants in streams, rivers, and lakes, which is where we get our tap water from. Third-party testing was done on 85 tap water samples by Moms Across America and Sustainable Pulse. The results showed that 35 of the samples had glyphosate levels up to 0.3 ppb. On average, 87% of Americans have measurable glyphosate residues inside their bodies. For more on how glyphosate impacts our health, see this study. We know we are getting exposed to glyphosate and it looks as though tap water may be a key root of exposure. This is the most compelling reason for filtering water using reverse osmosis.   Closing Thoughts Sarah is so grateful for AquaTru for giving our listeners such a steep discount on their filtration systems. Last week we talked about foundational principles, and Sarah considers filtering water as a foundational principle. Reverse osmosis is the next level thing. However, depending on where you live, if you live in an area where your water is likely to be contaminated, that shifts that priority. Stacy and Sarah are on a mission to educate, they never want to make listeners feel burdened with one more thing to worry about. Instead, you make informed decisions from education and we are here to educate you. Stacy doesn't want someone to spend a lot of money on a water filtration system without looking fully into the research and which system to buy. It is fascinating to Stacy that this is beyond heavy metal contamination, it is beyond glyphosate, that three out of four homes have contaminants beyond the prescribed measures in America. This was a fact that once she heard it, Stacy couldn't un-hear it. Is this a burden that you should be stressed out about - absolutely not. This is to educate you so that you can plan for if you want to make changes. A great place to start is to look at what is in your water. Use this site as a reference point. For you to be aware and to start looking at that is all that we are trying to provide. If you are concerned about your water quality and do feel like a good water filtration system is a good investment to make, AquaTru has given our listeners $150 off. Simple visit this site to get that discount. Sarah wanted to thank AquaTru again for sponsoring this week's episode and for being such a good sponsor to provide listeners with such an amazing discount. Thank you listeners for being a part of the show. We love hearing from you and your feedback. Jessica, thank you for your nice complement. If you have questions that you want us to follow up on or different topics that you want to hear about, we welcome you to email us using the contact forms on our blogs. Please engage with us on social media. If you learned something from listening to one of our shows, the best thing you can do is share about it. Please also leave a review in whatever platform you are listening to. Thank you so much, listeners! We will be back next week. (1:05:22)

Dans cette capsule Jean-Yves Dionne: Franchement Santé, diffusée en Facebook Live le 5 Mai: Les bactéries de l’intestin sont un monde en soi. Très complexe et partiellement connu. Regardons la nouvelle L’article Franchement Santé – Les Capsules – 5 Mai: COVID-19, microbiote (Prevotella) et autres bactéries est apparu en premier sur RadioH2O.

Dans cette capsule Jean-Yves Dionne: Franchement Santé, diffusée en Facebook Live le 5 Mai: Les bactéries de l’intestin sont un monde en soi. Très complexe et partiellement connu. Regardons la nouvelle L’article Franchement Santé – Les Capsules – 5 Mai: COVID-19, microbiote (Prevotella) et autres bactéries est apparu en premier sur RadioH2O.

Časovnica: [00:00:55] O projektu nadaljnjega izobraževanja o prehrani, vadbi in kritični presoji literature. Kultura pogovora preko socialnih omrežij ter epilog poizkusa svetovnega rekorda v mrtvem dvigu. [00:19:35] Inteligenca in kritično razmišljanje nista ista stvar. Zakaj pametni ljudje počnejo neumnosti. Zakaj je kritično razmišljanje ključ do dobrega življenja. [00:31:25] Kofein kot dopolnilo za izboljšanje zmogljivosti ter kako genotip vpliva na časovni vnos kofeina. [00:44:25] Vpliv mikrobiote in probiotikov na hujšanje. Visok vnos vlaknin in nižji vnos maščob za optimalno zdravje prebavil. [01:15:05] Zakaj vzdržljivostni športniki potrebujejo več beljakovin. [01:22:45] Zaključek.   Omenjeni članki: Zakaj pametni ljudje počnejo neumnosti: Why Do Smart People Do Foolish Things: https://www.scientificamerican.com/article/why-do-smart-people-do-foolish-things/ Vpliv genotipa na jemanje kofeina: Grgic et al. CYP1A2 genotype and acute effects of caffeine on resistance exercise, jumping, and sprinting performance. J Int Soc Sports Nutr 17, 21 (2020). https://doi.org/10.1186/s12970-020-00349-6 Mikrobiota in hujšanje: Fragiadakis. et al. (2020) ‘Long-term dietary intervention reveals resilience of the gut microbiota despite changes in diet and weight', The American Journal of Clinical Nutrition. Oxford University Press, pp. 1–10. https://doi.org/710.1093/ajcn/nqaa046  Hjorth et al. (2018) ‘Pre-treatment microbial Prevotella-to-Bacteroides ratio, determines body fat loss success during a 6-month randomized controlled diet intervention', International Journal of Obesity. Nature Publishing Group, 42(3), pp. 580–583. https://doi.org/10.1038/ijo.2017.220 Višji vnos vlaknin in nižji vnos maščob za optimalno zdravje prebavil: O'Keefe et al. (2015) ‘Fat, fibre and cancer risk in African Americans and rural Africans.', Nature communications, 6(May 2014), p. 6342. https://doi.org/10.1038/ncomms7342 Le Leu et al. (2015) ‘Butyrylated starch intake can prevent red meat-induced O6-methyl-2-deoxyguanosine adducts in human rectal tissue: A randomised clinical trial', British Journal of Nutrition, 114(2), pp. 220–230. https://doi.org/10.1017/S0007114515001750 Meta-analize o učinkovitosti probioikov pri hujšanju: Mazloom et al. (2019) ‘Probiotics: How Effective Are They in the Fight against Obesity?', Nutrients, 11(2), p. 258. https://doi.org/10.3390/nu11020258 Mohammadi et al. (2019) ‘Effects of pro-/synbiotic supplementation on anthropometric and metabolic indices in overweight or obese children and adolescents: A systematic review and meta-analysis', Complementary Therapies in Medicine. Elsevier Ltd, 44, pp. 269–276. https://doi.org/10.1016/j.ctim.2019.05.008 Cao. et al. (2020) ‘Effect of probiotic and synbiotic formulations on anthropometrics and adiponectin in overweight and obese participants: A systematic review and meta-analysis of randomized controlled trials', Journal of King Saud University - Science. The Author(s). https://doi.org/10.1016/j.jksus.2020.01.011 Potrebe vzdržljivostnih športnikov po beljakovinah: Kato et al. (2016). Protein Requirements Are Elevated in Endurance Athletes after Exercise as Determined by the Indicator Amino Acid Oxidation Method. PloS one, 11(6), e0157406. https://doi.org/10.1371/journal.pone.0157406 Bandegan et al. (2019). Indicator Amino Acid Oxidation Protein Requirement Estimate in Endurance-Trained Men 24h Post-Exercise Exceeds both the EAR and Current Athlete Guidelines. American Journal of Physiology-Endocrinology and Metabolism, 316(5):E741-E748. https://doi.org/10.1152/ajpendo.00174.2018   Sledite nam: Nenadov instagram: @nenad.feelgood Matjažev instagram: @matjaz.feelgood Feelgood Skupnost na Facebooku: https://bit.ly/feelgoodskupnost Spletna stran: https://www.feel-good.si   Poslušate nas lahko na: Podbean: https://bit.ly/podbean-zdp Stitcher: https://bit.ly/stitcher-zdp Pocket Casts: https://bit.ly/pocket-zdp Podcast Addict: https://bit.ly/addict-zdp Castbox: https://bit.ly/castbox-zdp iTunes: https://bit.ly/itunes-zdp  

Thanks to the University of Minnesota for sponsoring this video! http://twin-cities.umn.edu/ Our modern lifestyle and diet are leading to the extinction of parts of our microbiome, but we can use what we've learned from dealing with nearly-extinct macrobiota, like bald eagles, to understand the consequences and find solutions. Thanks also to our Patreon patrons https://www.patreon.com/MinuteEarth and our YouTube members. ___________________________________________ To learn more, start your googling with these keywords: Extinction: the termination of a kind of organism or group of kinds, usually a species Endangered: a species that is very likely to become extinct in the near future Microbiome: a community of microorganisms (such as bacteria, fungi, and protists) that inhabit a particular environment and especially the collection of microorganisms living in or on the human body Hunter-gatherer: a member of a culture in which food is obtained by hunting, fishing, and foraging rather than by agriculture or animal husbandry Prevotella: a genus of bacteria most commonly found in the microbiome of people who eat a plant-rich diet DDT: an aromatic organochlorine sometimes used as insecticide banned in the U.S. that tends to accumulate and persist in ecosystems and has toxic effects on many vertebrates C. diff: (short for Clostridium difficile) a toxin-producing bacterium which can infect the bowel, causing illness with diarrhea and fever, especially in people who have been treated with antibiotics Antibiotics: an antibacterial substance (such as penicillin, cephalosporin, and ciprofloxacin) that is used to treat or prevent infections by killing or inhibiting the growth of bacteria in or on the body Probiotics: a microorganism that when consumed (as in a food or a dietary supplement) maintains or restores beneficial bacteria to the digestive tract ___________________________________________ Subscribe to MinuteEarth on YouTube: http://goo.gl/EpIDGd Support us on Patreon: https://goo.gl/ZVgLQZ And visit our website: https://www.minuteearth.com/ Say hello on Facebook: http://goo.gl/FpAvo6 And Twitter: http://goo.gl/Y1aWVC And download our videos on itunes: https://goo.gl/sfwS6n ___________________________________________ Credits (and Twitter handles): Video Writer, Director, and Narrator: Julián Gustavo Gómez (@ittakesii) Video Illustrator: Arcadi Garcia Rius (@garirius) With Contributions From: Henry Reich, Alex Reich, Kate Yoshida, Ever Salazar, Peter Reich, David Goldenberg, Sarah Berman Music by: Nathaniel Schroeder: http://www.soundcloud.com/drschroeder ___________________________________________ References: De Filippo, Carlotta, et al. "Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa." Proceedings of the National Academy of Sciences 107.33 (2010): 14691-14696. Gomez, Andres, et al. "Gut microbiome of coexisting BaAka pygmies and bantu reflects gradients of traditional subsistence patterns." Cell reports 14.9 (2016): 2142-2153. Hand, Timothy W., et al. "Linking the microbiota, chronic disease, and the immune system." Trends in Endocrinology & Metabolism 27.12 (2016): 831-843. Harmon, K. "Bugs inside: what happens when the microbes that keep us healthy disappear." Sci Amer (2009). Harrison, Christy. “Disappearance of the Human Microbiota: How We May Be Losing Our Oldest Allies.” ASM.org, American Society for Microbiology, 8 Nov. 2019, www.asm.org/Articles/2019/November/Disappearance-of-the-Gut-Microbiota-How-We-May-Be. Henson, Shandelle M., et al. "Predator–prey dynamics of bald eagles and glaucous‐winged gulls at Protection Island, Washington, USA." Ecology and evolution 9.7 (2019): 3850-3867. Jacobson, Rebecca. "Can We Save Our Body’s Ecosystem from Extinction?." PBS Newshour (2014). https://www.pbs.org/newshour/science/theres-extinction-happening-stomach. Rees, Tobias, and Nils Gilman. Opinion | The Silent Microbiome Crisis. The Washington Post, 26 Feb. 2018, www.washingtonpost.com/news/theworldpost/wp/2018/02/26/microbes/. Sonnenburg, Erica D., and Justin L. Sonnenburg. "Starving our microbial self: the deleterious consequences of a diet deficient in microbiota-accessible carbohydrates." Cell metabolism 20.5 (2014): 779-786. Tito, Raul Y., et al. "Insights from characterizing extinct human gut microbiomes." PloS one 7.12 (2012). Trotter, Bill. Seabirds Declining as Eagles in Maine Recover. Bangor Daily News, 6 Aug. 2011, bangordailynews.com/2011/08/05/environment/seabirds-declining-as-eagles-in-maine-recover/. US Fish and Wildlife Service. "Bald eagle recovery plan (southwestern population)." US Fish and Wildlife Service, Albuquerque, New Mexico (1982). Velasquez-Manoff, Moises. "How the Western Diet Has Derailed Our Evolution." Nautilus (2015).

L'obésité, la nicotine et la bactérie Prevotella : quel rapport avec le Covid-19 ? Aujourd'hui, je reviens sur les news et débats qui tournent autour du Covid-19 et bien-sûr, nous allons beaucoup parler de nutrition car vous êtes de plus en plus nombreux à me poser des questions, notamment sur l'alimentation pendant le confinement car il semble que beaucoup d'entre vous ont pris du poids. D'abord, je m'arrête sur le sujet de l'obésité vis-à-vis du Covid-19. Ensuite, j'aborderai les sujets suivants : l'histoire de la nicotine : l'affaire du tabac, en étant fumeur, on aurait moins de possibilité d'attraper le covid que les autres ? La bactérie Prevotella, joue-t-elle vraiment un rôle dans l'infection en ce qui concerne le covid ? Les traitements actuels, l'histoire des tests et de la sérologie. Retrouvez mes réponses à ces questions dans ce podcast. N'oubliez pas de relayer notre opération #stopobesite et merci de votre soutien et de faire votre analyse minceur gratuite avec Jean-Michel Cohen Le Docteur Jean-Michel Cohen a élaboré un Programme Minceur, Savoir Maigrir, qui permet de perdre du poids rapidement, durablement et sans aliments interdits. Le principe de sa méthode est assez simple : Pour mincir, il faut limiter les apports caloriques non pas en se privant mais en réduisant sa consommation calorique grâce à un choix de bons aliments. Pas de méthode miracle, mais du bon sens... Ce régime met ainsi l'accent sur les fruits et légumes, crus ou cuits, dont la consommation presque illimitée est encouragée. Et pour un résultat optimal, il faut y aller en douceur. La première semaine, le programme du Dr Cohen autorise un apport de 1400 à 1600 calories par jour. Vous souhaitez mieux manger, maigrir, rééquilibrer votre alimentation, apprendre à toujours faire les bons choix alimentaires ?Faites votre analyse minceur gratuite avec Jean-Michel Cohen Découvrez l'ActiBox Minceur Dr Cohen, la boîte d'assistance à l’amaigrissement conçue pour éviter tous les “parasites” du régime Abonnez-vous ici à la chaîne Savoir Maigrir sur Youtube Découvrez la chaîne Youtube de Jean-Michel Cohen Consultez les Lettres d’Information du Dr Jean-Michel Cohen Visitez la page Facebook Savoir Maigrir avec Jean-Michel Cohen Suivez les stories de Jean-Michel Cohen sur Instagram Suivez Jean-Michel Cohen sur Twitter Les avantages de la méthode Savoir Maigrir :-Grande diversité des aliments proposés-Fruits et légumes à volonté, qui permettent de se sentir rassasié-Absence d'interdit formel : le système d'équivalence permet de pouvoir craquer de temps en temps-Le schéma est assez flexible, puisqu'on peut alterner des journées à 900 calories et des journées à 1400/1600 calories-Le programme à 1400/1600 calories peut être fait sur le long terme-L'accent est mis sur l'activité physique, ce qui est très positif. A la pointe de la recherche en nutrition depuis plus de 30 ans, Jean-Michel Cohen est auteur de nombreux best sellers en nutrition et le nutritionniste français leader du coaching minceur sur internet.

All right, welcome to the gut check project. We're going to call this episode COVID two and a half. It's going to be a shorter form. And in lieu of my regular host, I have asked my gastroenterology partner, Dr. Stuart Akerman to join us. Because what we wanted to do is go over two recent journal pre proofs one of them being accepted in the journal of gastroenterology and the other one with the American College of gastroenterology both actually augment each other and I think it's a great opportunity to look at something that a lot of people may not realize. Dr. Akerman, thank you so much for joining me on this lovely Sunday morning, March 29 2020.Thank you so much for having Dr. Brown. And as you can see, we're both in our respective social isolation bunkers. While we have a conversation over the internet to talk about these two interesting articles, you know, the data coming out of China is fast and fast and loose. It just more information comes out every day and thankfully people are aggregating it and analyzing it so that we can get a better plan of attack against this viral pandemic.Exactly. Right now, to date 683,641 people have COVID19 32,144 have died worldwide. Unfortunately, the US numbers continue to go up. We're at 123,828. 2,229 people have died from COVID 19. So I really admire the scientists around the world. It is like drinking from a fire hydrant at times when you go down these rabbit holes. But fortunately, these scientists put together data in two journals that you and I know it's very hard to get into, very highly respected the American Gastroenterology Association Journal and the American College of Gastroenterology. So I'm in...And I just want to point out, you know, in case people are starting to feel like maybe things are turning here in the United States, you know, we're still very much in the thick of it and this is applicable every single day all over because, you know according to our current analysis, cases are getting diagnosed and doubling at a rate every two days. We're very much still in the thick of this increase in the curve100% and one thing that we're going to be discussing today is we may be missing a lot of these people. And we may be missing a very important route of how we could be infecting each other. So let's just jump right into this because the science is well for you and it's pretty interesting because it really involves us if you're wondering why two gastroenterologist are talking about a virus. Neither one of us are virologists or infectious disease doctors, who are most of the people out there talking Well, now we got to play a big role in this. So let's talk about the first article. The title is COVID19 gastrointestinal manifestation, and potential fecal oral transmission. This article is out of Shanghai. Dr. Akerman, I will just throw it to you real quick that, can you give us an overview of this article?Yes. So this article is, like you said, coming out of Shanghai, it talks about patients that were tested for COVID19 and found very positive and that even after discharge, so in other words, they did well, they thankfully recovered. And this is not, you know, similar to what's happening to us. This is not someone who, you know, was sick for a day or two, they may have been ill possibly ventilated in the hospital for weeks on end, discharged, and still displaying evidence of virus on stool specimens that were taken to culture.Absolutely, because right now, the way that most people and certainly at the time when China was doing this, everybody to try and detect SARS, CoV2 the virus that causes COVID19. There, you're doing throat swabs. And what they're looking for is the viral load right there and I will say that on a prior episode, we discussed how this is 1000 times more contagious than the SARS 2003 outbreak, and they're actually showing much higher viral loads in the back of the throat. So it makes sense that that's where we're going. But now there's evidence that non respiratory routes like you're talking about include the digestive system. Now one of the theories behind that is is that the same receptor that the virus binds to called the h2 receptor, is heavily concentrated in the gastrointestinal tract, and also the lungs. And so once the virus comes in, it sees this receptor, it gets integrated into the cell. And then once it's there, it hijacks the cell, and that's how it replicates. So the implication that the gut is involved is huge. So what's really I think, fascinating is that these guys figured this out and figured out a test to actually look for in the stool.That's right, and there are two. There are two laboratories in China that are currently successfully isolating it from the stool using PCR techniques. And hopefully we'll be able to commercialize that in the near future to have it available for water distribution. You know, it's a big deal to be able to isolate the live virus because evidence of virus is not the same as viral activity or active infection. And what they found in this study is that they have essentially proof of live virus and if live virus is shedding, that means that the patients can still be contagious can still give it to other people and act as vectors.100%. In fact, there's we're probably missing a lot of people because this article goes on to say that this appears to show this fecal oral route the next article goes way deeper into it, and that's where we get into the nuts and bolts. They did reference in 2003, remember that this virus is very similar in structure to the SARS 2003 virus, that is the coronavirus so when they say novel, coronavirus, it's it causes a different type of infection. But a lot of the data they do look back and go, oh, SARS 2003 did this. What they did show is that some of those people had liver damage. And on liver biopsies back then they showed hepatitis. And they were questioning whether it was due to drugs or whether it was actually due to the virus. And the next article, the next article we get into really goes a little bit more into that. These guys even implied that if it binds to the h2 receptor, then there's h2 receptors in the GI tract, but also in the liver, which is something that you're very familiar with and even the bile ducts or cholangiocytes, can you explain everybody what that aspect means and that part of the gastrointestinal system?Yeah absolutely. So the liver is an organ that we have it sits in the right side of our body and it helps kind of like a filtration system. And there are many, many different injuries that can happen to the liver. I think the most common ones, we think about our viral illnesses like Hepatitis B and Hepatitis C, we talk about fatty liver disease a lot lately, and then probably the most common is alcoholic liver injury, right? If you drink either enough or enough over time, you start damaging those cells. But the liver has different kinds of cells there or the liver, liver tissue cells themselves, which are called hepatocytes. And then there's an intricate bile system called the bile ducts, kind of like a tree where all the branches are sitting in the liver and they drain down to the trunk, and that trunk exits out of the liver goes through your pancreas, and then empties into the small intestine. So when we talk about digestion and bile flow, we're talking about bile which originates in the liver and the cells that line that are called cholangiocytes. And in reference to this article, they found that h2 expression is significant in cholangiocytes in about 60% of cells and hepatocytes, maybe a little bit less, only about 3%. So to be more specific when we're talking about the potential for liver injury, yes, liver injury in general, but in specific, a lot of bile duct injury, also called cholangiopathy, or cholangitis. So I want to clarify the Dr. Akerman this is actually his subspecialty. He is trained extra for one particular thing, which is to do this invasive procedure called an ERCP, which is a life saving procedure for some people, where he actually goes into this bile duct and can remove stones and things like that. While you were talking. I was thinking, wow, if it's upregulated, there were gastroenterologists we may be more exposed than we actually thought you may be more exposed than me. Now after hearing that, yeah, we're doing really...Yeah and unfortunately there's not much PPE that we can use for things like that. We have to be extra vigilant to be sure that we're not being exposed, or at least the least amount possible. While we try to help people with emergencies.I know as soon as you said that, I was saying thinking oh my goodness, how many people can come in with elevated liver test etiology unclear? Is it COVID and we're gonna get into the next article, which really gets you thinking about how many people may be may be missing. So just to summarize, this first article was really just showing kind of the basis that look, there is a potential way that the virus can get into the gastrointestinal tract. The next article, which in my opinion is a little goes into some really cool data about different things. And then this is where after that I want to expand on some different ideas about where we think this is heading on a gastrointestinal standpoint, what are the implications of all this? This one has been accepted, it's a preprint that's been accepted into the what we call the red journal, which is the American College of Gastroenterology. The title is clinical characteristics of COVID 19 patients with digestive symptoms in Hubei, China, a multi-center study. So long winded title, basically these guys, and I really admire them for doing this. They just keep going back looking at the data, this same group had published something earlier in the month, I mean, in one month to come out with two different articles is pretty amazing. This is what they're doing is they're looking in an aggregate of patients, and they looked at 204 patients with COVID 19. And of course, most of them presented with fever and the usual things, but then they started going, wait a minute. Now let's go back and start asking questions. Let's go back and look at their charts. So this is sort of a chart analysis. This one I think, is a little bit more interesting. Why don't you give just a quick overview of your take on this article, Dr. Akerman? Yeah, so I agree this, this was a little more nitty gritty and looked at actual patient data analysis and provided a lot more information. So in this study, they looked at 204 patients, the average age of the patient was 53, which I think is a really important piece of information because we keep talking about how patients over 60 over 70 are high risk patients. But you know, an infection sometimes doesn't know age. And most patients almost almost all presented initially, or at least presented for their COVID diagnosis, I would say, with respiratory symptoms, but when they looked at their overall symptoms, not just focusing on their cough and shortness of breath and things along the respiratory side, they found that 50% of the patients had digestive symptoms as well. Stop right there. Say that one more time.Yeah, so in addition to the respiratory symptoms, nearly more than one in two patients had some sort of digestive issue as well that they were noticing with the onset of their symptoms,And we won't we're going to get into those digestive symptoms, but I thought something very interesting that when they looked back 78.6, almost 80% of the people had anorexia. Meaning they were not hungry, and that there's a relevance to this. And I'm going to I'm going to piece it together later. But yeah, you're doing a great job, but it didn't mean to interrupt there.Okay, no worries. So, yeah, like you said, you know, almost as 78% of patients had some form of a lack of appetite or anorexia, a third of patients had diarrhea. And several of them also had abdominal pain and vomiting. You know, things we don't necessarily associate with a respiratory illness like, like a pneumonia or bronchitis.100% I do want to point out that the diarrhea, this is what's really interesting, because, I mean, this is something you and I deal with every single day people come in and they this is this is our bread and butter. What I was shocked on this article is that the diarrhea was not that severe. And it was actually three loose stools a day on but as the disease got worse, the diarrhea got worse. So I would not even think I'm not as a ER doctor ICU Doctor, I wouldn't be going, oh, do you have diarrhea? and somebody's like, listen, I'm feeling pretty bad here. Yeah, I guess I got three loose stools a day. How long has that been going on? I don't know, two weeks. Now think about that. This is what I'm implying that maybe that because the other really interesting thing about this study that I found incredible was all the people with gastrointestinal symptoms, or the majority presented after having symptoms for 8.1 days, as opposed to the people that just presented with respiratory symptoms that presented earlier, which means these people were out in the community longer before they came in. So is it plausible that the gastrointestinal symptoms were there and they were ignoring them? And then it became pulmonary, which then brought them into the hospital?Right? They make that comment to that effect, and it seems that there was a delay in diagnosis and the patients who had gastrointestinal symptoms, and you know, you can make the argument that it might be like you said, right, someone called and said hey, you know, I've got this vague abdominal discomfort, I'm not really that hungry, my bowel habits are starting to change, I'm getting a little bit of looser stool and, you know, someone might say, you know, we've got other things going on, you know, try some Imodium for a couple days, take it easy, you know, give me a call back if you're not feeling well. And then two, three days later now also you got the pulmonary symptoms, and you know, everyone that is on top of that getting tested and, you know, seeing who needs isolation who needs to be admitted and treated. But the one of the wake up calls from this article is, maybe we have to start paying attention, maybe those patients that call and they're having new onset symptoms, you know, not someone who has maybe chronic symptoms that get exacerbated, but someone who hasn't been having any kind of abdominal discomfort or has bowel regularity, and all of a sudden they're off. You know, do those people have to be in a heightened state of awareness and say to that, well, they don't necessarily have to run to a hospital. But maybe you say to them, you know what, I need to follow up with you in a day or two because I needed to know if those symptoms are evolving, and if we have to take this in a different in a different route.So can you imagine that the first article that we discussed, we talked about companies developing a rapid acid to see if there's viral shedding in the stool? So now we're gonna I mean, mark my word once it becomes easy, this will be the norm for us. Just as like when somebody has significant diarrhea. We do our C diff testing, we do our stool culture. We do fecal leukocytes, lactoferrin, calprotectin, all these things that we do as specialists, we're going to end up looking for SARS CoV2 coming out in the stool with this if we can develop a rapid test.Yeah, I mean, I think the possibilities are I don't want to say endless but but there's, there's many, you know, Dr. Brown and I utilize the services of a large pathology lab in the East Coast that has currently had to close down production of their stool tests until we figure out what's going on in COVID because of these two studies that are showing the potential for special In the fecal oral route, because they don't know if all the samples that they're processing might have COVID in them. But imagine if there was rapid testing. And they can add that to their one day turnaround test for acute bacterial and viral infections. It could be a game changer.Yeah. And I actually admire them for taking the aggressive route of stopping business because there is the potential that they're exposing their employees to this. And then of course, part of me is just like, no, you're the one person needs to keep going and help us figure this out. But we're all learning as we go here. So now, this is also something in this study when they looked back. Well, first of all, let's talk about how the people that that had gastrointestinal symptoms tended to have more severe disease, those that had liver issues needed more meds, and anti microbials and things like that showing that once it somehow affects the liver now whether it's the drugs or whether it's the virus attaching. The one thing I'm a little bit disappointed in this study is that they did not list what the alkaline phosphatase was. And just explain that because in the first part of this, we talked about the cholangiocytes.Right so, you know, this is, this is how it works in the medical field, you know, when you publish, you know, you have a lot of a lot of effort, a lot of sort of sweat and tears that go into analyzing and publishing your data. And then everyone kind of gets to sit around and then reanalyze it and ask all the questions, and it'sGee it's almost like a lawyer looking at a medical file, isn't it?Yeah, it's, it's kind of similar. So you know, we have the ability to look at both of these studies to get all that data together, and then look at it and analyze it. And now that we have the data from the first study, which, you know, tells us how this preferential expression of h2 in the cholangiocytes in the bile ducts, it'd be more interesting for us to know, okay, well do the signs and symptoms, meaning the laboratory values of cholangiopathy and inflammation and irritation of the bile duct, do they go up in preference? So when you look at we talk about this a lot and patients here saying, oh, I just need you to go get your liver tests done. What does that really mean? What that means is there's a panel that pretty much every lab the United States does for us, that looks at several different markers. And some of those markers reflect the liver tissue itself, the hepatocytes, some of those markers more reflect the bile ducts or the cholangiocytes. And in this study, they really focused more on the hepatocyte markers than the cholangiocytes markers, and it might be an opportunity for us going forward to look back at these patients who are COVID positive pull their liver test, and in particular, look at this alkaline phosphatase and bilirubin levels, which are more reflective of the cholangiopathy and see, does it go up? Is there a specific value does it go up two time's upper low normal four times five times is there a correlation that we can make with the severity of the disease?Okay, quick side, rabbit hole here. This is what happens when you do a podcast with somebody with ADD. You just got me thinking about something. So a lot of people that are dying in the ICU, they're dying and multi organ failure and sepsis, obviously pneumonia, we've been blaming the pneumonia. What if there could be a component of some colangitis, for instance, causing this colangitis is the infection that can happen in the bile ducts where it it can't get out where the basically the bowel can't get out. Now, I just thought about something wild and this is this is your I'm challenging you to do this as...on the fly. Could you imagine? So what Dr. Akerman does is he gets into the bile duct and frequently he places plastic stents or stents to open things up. They I just got an article which showed so you know, my world is this molecule of polyphenols. That's where I do a lot of research. That's where we see, we now realize that these polyphenols have antiviral activity, they have antimicrobial activity. I just was sent a pre proof on possibly making polyphenol masks and polyphenol disinfecting cloths because it's that effective. In fact, we're talking about a rapid test on last on COVID to show there's a German company that actually is doing an asa rapid asa to do a filtration, what's called an agglutination test where they put the SARS CoV-2 virus and then they put it in with quercetin and luteolin which are polyphenols, and then they tag those and if it clumps, they know that that's doing it. That's how strongly it binds so just thinking like that coding stents with possibly hydroxychloroquine possibly polyphenols, possibly other anti things that could be really interesting, because if the concentration of virus is in the bile duct, you may end up having something to directly combat the virus,Right, it's almost akin to placing radiation beads for local tumors where, instead of treating the entire body, you focus your efforts on the one area that's problematic and just try to focus on it instead, you know, kind of like just to localized therapy and sometimes that works better than the systemic therapy.I, I'm really proud of you as a, as a clinician to not tell me to stop recording and get up and go, I'm gonna go work on this right now. This could be my thing.Well, hopefully enough people see this and enough bright minds are getting tasked to it right away. I know,That just just hit me coding a stent with an antiviral in because one thing that we're going to learn about this, these numbers are are there but until we come up with a true vaccine, which is not going to happen for quite a while, these other treatments are really good. This is not going to be a blizzard and then we're done. I feel like this is going to be seasons, it's going to come and do this. It how infective it is. So maybe starting to think about something like that is really cool. That was quick side note. So.Yeah but you know what? It's relevant, right? Because the reality is right now, we're focusing on isolating the individuals, and then essentially treating them with supportive therapy, right? If you can't breathe, and we have to put you on a ventilator, that helps you breathe to give you time to fight the virus, right? I mean, we there's a lot of talk about, you know, plaquenil and chloramphenicol. And then these, you know, other azithromycin and all these drug combinations that may or may not have benefit. And, you know, the reason is simple. We don't have a treatment currently, which is true of many viruses, right? Many viruses. There are some that we have antivirals for and they have specific actions against that virus like HIV and hepatitis B and hepatitis C, but we don't have direct therapies right now. We're really, you know, sort of playing defense rather than on offense. And if we can figure out a way to, you know, figure out which individuals would benefit from specific therapies and then have those targeted therapies available. It could change the entire landscape of the disease. Oh, it could totally like if we realized that I mean, we could do this in our hospital where we're at we're kind of a funnel hospital we get a lot of the people are not a lot but if we could look at those charts, and say somebody has presented with a fever and cough they now imagine the flow of this. Okay, so somebody comes in says, I have a fever and a cough. I'm not feeling well I've got myalgia. Okay, let's do a SARS test throat swab. Next thing is, Do you recall not wanting to eat we're going to get into that in a second. Do you recall having a change in your ability to smell? Have you had any change in your bowel habits, then it becomes test the stool while they get it admitted, alkaline phosphatase is up. And then it's like Dr. Akerman, we needed to get in there we believe this person is going to have a worse outcome. Because it is now in the liver. It is in the cholangiocytes, we believe we know that they have COVID 19 your role could be a play something which is really cool.Yeah. And it's interesting. You brought that up about the sense of smell or anosmia. Actually, it was my sister in law, Dr. Rachel K over and Rutgers University who started noticing that about some of the COVID patients and just relentlessly looked into this and found out that that is a significant symptom that is a common thread across all these COVID patients.Absolutely. And so when I saw the anorexia and the first article published at the very at the end of February where they were discussing gastroenterologist perspective on COVID, I don't know if you remember that it was it was with our Neal Brannon and a few of our other of our, you know, well known academic publish...Published in GIE. Yeah, yeah, they were talking well, gi issues are not a big deal. And they threw out the anorexia, which now I'm throwin' it back in because I see people with a disease called dysgeusia, which is chang in taste. And we frequently get people to come and go, you know, I'm just not smelling right. And we check their vitamin levels and all this other stuff. So I believe that that is a gastrointestinal symptom, it is an EMTs symptom as well. So I when you look at that, I think the sense of smell and that is become kind of sensationalized right now in the news, for some reason people find that fascinating to write about, but that's impressive that your sister in law was paying attention to that, which is exactly why we should be paying our fields to be paying attention to the mild diarrhea type thing, but we should be really paying attention to the anorexia, anosmia, which is what that's called, which is lack of sense of smell.Yeah, and you know, that might be a method for us to triage patients right based on their symptoms because like you said, we see diarrhea all the time. This is this is what we do. Right? If you have diarrhea, you talk to a gastroenterologist so how do we, as sort of the gatekeepers figure out, you know who we can just say, you know what, just stay home it's totally okay. And who are the and you can see my daughter in the background here this is what happens when you do it in the in the home office rather than doing it in the studio, but this is how we have to figure out maybe...Well, this is funny because I'm you know, we're all watching a lot of news and it's just, it's a lot of people are recording from home and stuff like that. Just out of nowhere, a cat will jump on somebody's lap and be like oh, look at that, live shot.Just play it off. Yeah.But, you know, maybe we need to have a little mental checklist right? If a patient comes to you and says, You know what? I started having some diarrhea the last few days. I'm a little worried. I've learned about some of these things. He's You know, we've been talking about it in the press, do you think that I have COVID? You could say then, well, ok, what are your other symptoms? Do you have any kind of change in your appetite? Do you have a change in your smell? Have you had any abdominal discomfort, nausea and vomiting. And if you've got kind of enough of those things stacking up, you know, we don't have enough resources right now to go tell them to go get COVID testing, right? We can't send every single patient that has the symptoms. So how are we going to figure that out? Maybe we check liver tests, right? Maybe we send that patient and go get a pretty simple, easy blood test. And if their liver tests are abnormal along with it, maybe that index of suspicion now goes higher. Maybe we say to them, you know what? Maybe we're catching this before you get your respiratory symptoms. Let's get you swabbed.Yeah swabbed or fecal tests we can do this. I want to talk I want to finish up this article. And then I want to talk about a few other things because this is an ever expanding deal. I have actually spent all week I did three shows this past week with doctors with specialists, and I've been reading, I'm just nau...I'm not nauseous because I don't want to sit there. Yeah we don't have to worry about putting you through the algorithm right now.Yeah, we don't want to do that. But alright, so I thought, well, this is very interesting. Some interesting thoughts as what I'm going to call it. Most people in this study could not recall a clear exposure. So it's not like, oh, I was in and this is a Chinese study. And so it's not like I was in Wuhan, my brother came back from Wuhan, because I got I have other things that we'll talk about that average time the hospital was 8.1 days. So it was beginning of symptoms that they could track back. So they're asking the gastrointestinal symptoms 8.1 days, imagine I'd love to sit with your sister in law and say, what if the anosmia the sense of smell starts going away before that? Different theories to that Ear, Nose and Throat doctors have been showing that that happened in SARS 2003. I just got an article here sent to me this morning that shows that it could be related to the microbiome. And we'll get into that next. But there it appears that this virus could have a partner in crime called a Prevotella bacteria, which may be causing the severe pneumonia. Separate, very detailed thing to talk about. Here's something else that I was surprised about this. Everybody's like, well, people are dying. But, you know, the...China didn't know what to do. Did you see that? 90% of these people received antiviral therapy. China was all over it, man. They were trying everything.Yeah, I mean, look, I mean, their pandemic response, you know, after getting caught a little bit flat footed in 2003. It was nothing short of amazing. Right. I mean, they shut borders. They shut down cities as quickly as they could, and you know what I mean? That's why that they're finally falling on the other side of the curve.Yeah. And they had, you know, 7.8% of these people went to the ICU with a death rate of 17%, which is much better than what we initially saw where it was, like 87% of people that went on a vent died. But I don't know if if we're as aggressive to throw drugs at people as possibly they were, I don't know if we have our hands tied here by the FDA. I don't know if our physicians are just trained in a different way where it's like, that's not standard of care.Right. Some might just be culture, right? We're more focused on diagnostics to sort of say, rather than throw everything in the kitchen sink, let's figure out what makes sense, right. I mean, especially as we get into this era of antibiotic stewardship, where we're worried that a lot of our, you know, older generation drugs are losing their efficacy because we've used them too frequently, and there's resistance that's built up. I think we've all sort of gotten on that train, where we want to make sure that we're not just using it to use it right. You get this a lot when you see the primary care doctor and you've got a cough, and you say to them oh I just need an antibiotic. And they say, Well, you know, 90% of these are viral and antibiotics not going to do anything. So, you know, let's wait and see how it goes. And sometimes that's frustrating as a patient. But, you know, by not taking that antibiotic, you're kind of doing your your public health initiative on your own, that you haven't created more resistance.Even if it's not a resistance thing. Every time you take an antibiotic, you're just disrupting your own microbiome, and you need that microbiome to keep you healthy. It keeps your immune system healthy. Yeah. You did mention flattening the curve, the average hospital stay was 17 days. So we frequently talk about this everybody's like flattening the curve flattening the curve. What that means is that's an epidemiologic term called R0 R, little zero. And that means that at least I have not looked at it in the last week but at least a week ago the R0 in the United States was one person gets infected can infect three others that's what the R0 means and the reasonYeah 2.5 to 3 i think is the current numbers.And then with a hospital stay of 17 days, when I listened to Peter Addy as podcasts where he had an infectious disease doctor from New York on there, they did the math on when we will run out of beds. And that's the scary thing. Because if you need some sort of respiratory support, if you need some sort of IV treatment, there will be no beds to do that. That's why we all have to do our part and have remote podcasts here where we have special guests in the background. SoYeah, and I think anyone who's been paying attention to the news is not immune to what's going on around the country. I mean, you might not live in New York, but you're gonna be well aware of what's happening. I mean, there are hospitals that have run out of space in the morgue, and they have to set up external refrigeration sites in their parking lots. I mean, it's, this is this is real, right? And we have to do what we can to try to flatten that curve, right. Both On the healthcare provider sides figure out, you know, who needs help quickly? How do we isolate them? How do we prevent the spread? And from from everyone else, too, right? I mean, we talked about staying at home and avoiding spread. And it goes to exactly what you just said, if you have the virus, and you might have it for 2, 3, 4 weeks, there's some data to say that there could be an incubation period, longer than we thought, right? We keep talking about two weeks and self quarantine for two weeks. But there's some data that's come out that shows that it might be as long as 28 days. So you might be completely fine, feel great. But you're shedding that virus and you walk around and you go to the grocery store, and you come in contact with 15 people, right? Doing the math, those 15 people now can infect another for another 45 and those 45 and so on and so forth. And, you know, sometimes people it's hard to see if someone's not ill, right, it's hard to internalize that that can be happening.So let's let's talk about that analogy that you just said about going to the super market now in the first article, we discussed a fecal oral route and everybody's like, I'm not exactly at risk. Well, here's, here's how you're at risk the viruses. If you're shedding shedding it in your stool and you use the restroom, and you don't effectively clean your hands, then anything you touch may pass it. And I just thought about going to the supermarket and picking up the pi...the grapefruit or whatever, looking at it, holding it, putting it back, getting a different one. That could be a transmissible thing,Right? That's exactly it. Right? Most people and I don't know the numbers on this, but let me just look around what happens what what you yourself do, right? You might look at a box and try to read the ingredients and you're like, you know, maybe this isn't what I want right now. You put it back on the shelf. And you know, I think a lot of times when you say fecal oral people think I don't have stool in my hands. It's not an issue. That's not what we're saying right? Effective hand washing, which is 20 seconds. Getting between the fingers getting under the fingernails using hot water. You might be in a rush, you might not do it, maybe you don't know that you need 20 seconds. So you've got these little microscopic particles on your hands that are now touching the doorknob touching the handles touching the inside of your car when you go and you know, you could just who knows where it's going.Speaking of who knows why in the world, did everybody went out and get all the toilet paper? I'm still confused by that. As a gastroenterologist I did not understand that.Yeah, I mean, I'm not sure but I would definitely recommend that if someone needs that much toilet paper, they should get evaluated by one of us.if you were hoarding and you're going through that, please, it's time to get checked. Something else fascinating in this that they speculated something really tied to our field, which now may change our interactions with our critical care Doc's and our pulmonologist. Did you see that this these infections may affect the microbiome and I say the Prevotella bacteria may be contributing to this, and they refer to this as how does this affect the gut lung access? I was talking about the gut brain access. Now these guys were referring to gut lung. Is it possible that by not having a healthy gastrointestinal system, you're then predisposing yourself to possible lung injury? Fascinating thing that they brought up.Yeah, it's it's a very interesting point, right? Because you sort of think of immunosuppression as a global or systemic issue. Right? You're either immunosuppressed or you aren't. But does maybe poor gi microbe or gut microbiome health lead to sort of a cascade of events that ends with, you know, susceptibility to lung injury and infection as well.I mean, I have talked when I did Dr. Chang Raun's summit with a bunch of other doctors like Dr. Mark Hyman. We talked about the possibility that having a gastrointestinal tract which could be more permeable could allow infections to take place and allow it to get into your into your bloodstream and get into and turn on your immune system, since the get people with gastrointestinal symptoms tended to have a worse outcome, or at least they were sicker. Is that possible that the cytokine storm that we talked about starts in the gastrointestinal tract sets off the inflammatory cascade? So that's the little things that we that we're thinking about. I have...do you have anything else to add on this particular article?No, I mean, I think we talked about a lot and excuse me, I do think, you know, again, the take home points are that, not that we want to, you know, raise any alarms, we don't want everyone to worry that if they've got a loose stool that all of a sudden that means that they've got COVID, it's more that we want to raise awareness, you know, both on the side of continuing to stay at home, to encourage good hand hygiene, social distancing, because that's another way for the virus to spread and you know, take it seriously right? Wipe down all the surfaces, make sure you're washing your hands. And if you do end up having some symptoms, touch base, right virtual medicine is completely changing the way that you can see your doctors, you don't have to...I was just going to say that the both you and I are really doing a lot of telemedicine. And I love your idea that if I get somebody and I'm going to ask those questions, how's your smell? How's this? Then the next thing I'm going to do? I'm going to check some liver tests. To make sure and we can start gathering some of this data to you know, ourselves. So if you're, I think right now initial visit has to be in state. So if you live in the state of Texas, both Dr. Akerman and I can see you virtually and talk about these different things. I don't know if that's going to change anytime soon or there can be interstate. Am I wrong on that? Is that correct?Yeah, I know. CMS is discussing it in regard specifically to Medicare coverage, to try to get more physicians available for their Medicare patients, but I don't, I don't believe it's been passed yet but currently you have to be an in state resident they have lifted the restrictions about establishing the doctor patient relationship so it can be done via telemedicine. And you know, the nice thing about it is because it adds so much flexibility, there really is a lot more room for us to enact some of these protocols, right to say, okay, well I saw a patient on Monday, and they've had these symptoms and I don't want to raise alarms, I want to see how you're doing. Let's have you go to the lab, which is considered an essential business and it's still staying open. You go in, you get your blood drawn, you know, we get it back in a day or two, have the patient follow up again for another 15 minute visit. A quick visit on Wednesday is just check in and say okay, let's review your lab test. How are you feeling? Have you developed any new symptoms and then kind of go from there.Alright, let's do it. I do the same protocol for the anosmia as we see our patients. So if somebody says, you know, I've kind of had some loose stools and stuff like that, let's have the same protocol where we say I would like...do you have any oranges in your house? This is my theory, cut it right now in front of me smell it, does it smell exactly like an orange should smell? Or I was just saying orange, it could be anything that has a distinct odor.Right. That that that is universal. So everyone knows what it should smell like,Yeah, just think about that. Maybe you and I can come up with a little protocol where that'll be part of the physical exam or part of the history.Yeah, that was a great idea. Just another way to, you know, triage the patients and get everyone the excellent care that they need.Yeah, absolutely. So we're done with that study. Since I've been reading so much. I just want to bring up a few other different studies that kind of tie into this. There was a study out of China that showed a case report of a 25 year old woman, and this is early on, that her brother was in Wuhan came back. She that was her contact. She was hyper aware of everything, and then ended up developing fever myalgias everything went into the hospital had a very severe case. With a CT showing the bilateral infiltrates doing all of that, and so she had a pretty rough, absolutely classic COVID 19 with the CT exposure and her her progression,And am I remembering correctly that she had more mild imaging on presentation, but it's sort of blossomed very quickly into significant Pulmonary Disease?It did. And what's fascinating is over when they swab or it was a negative, and then somebody was smart enough to do an immediate PCR in her stool it was positive, and then they swabbed her three more times over a seven day period. All her throat swabs remained negative. The stool was how they were able to confirm the COVID 19 even though her presentation was classic for it. So that's something that's fascinating to me. It is one case it's a case report. Right and you know, you have to take it I don't say with skepticism because it's you know, it's real information, but you sort of have to take it for what it's worth, right? I mean, the value of data is typically an aggregate and it is a case study. But it proves our point from what we were discussing with these two articles that, you know, fecal oral is another route that we have to really be considering. And, you know, we do this for other things too. In our daily practices, we talk about h pylori treatments and evaluation. And there are multiple methods for how you can diagnose and find it. And sometimes it makes sense to do it with a breath test, sometimes with a biopsy, sometimes with a stool specimen. And you know, each test has their limitations, one might not one might come back negative where the patient actually has the disease. And if you have a high index of suspicion, you repeat it with a different asa, and you find this positive you can isolate it and treat it.Yeah. 100%. And then another one, which is probably going to be beneficial, but also scary. And I don't remember this I don't remember the number of people but somebody was looking at once they decided start looking at story. Somebody published a fecal viral shedding five weeks continued after pulmonary viral shedding stopped. So they got better. They didn't have any other viruses in their lungs, and they continue to shed the virus for five weeks. fecal now, just like you said, take that with a grain of salt. Very small number one person's take on it. But something to keep in mind also.Yeah, definitely. And I think the biggest thing to take away from that is that when someone hopefully, you know, successfully overcomes the illness, they're not totally out of the woods, right? They still have to make sure that they're practicing social distancing, that they're still adhering to all these recommendations that we discussed earlier, because they might still be a vector for spread to other people.Yeah. And that's, that's why I feel like we need to continue to try and educate as much as possible. This is not going to just go away. It's not like you know, it's that one thing like when do we lift these social restrictions? When do we allow these businesses to open up? And are we going to see a resurgence selling when that happens? Because all these people that said, Well, I socially isolated I had a mild cold. I don't know if it was that or not, but I'm sure I'm fine. And then ultimately, we need to continue with exactly what you're talking about. I mean, look, everybody should be washing their hands after they go to the restroom. And this is one of the reasons is that you don't need to see stool on anywhere on you to have the pathogen on you meaning the virus could be on you, which is you don't see the droplets coming at you. But yet there's virus coming at you. SoI would even go one step further with recommendations, you know, sort of borrowing from what we suggest to patients who develop a stool infection that we deal with a lot of pretty significant one in the United States called Clostridium difficile or C. diff. If you have a patient who tests positive or even suspect that they test positive, you tell them to go into contact Isolation in their own home, you know, what does that mean? It means that they have to use their own bathroom if possible. So if there are multiple bathrooms in the house, they should really be just using one everyone else in the family should be using a separate bathroom and just be super vigilant with wiping things down even if possible. And now it's a little bit difficult with a lack of resources but using Lysol wipes bleach wipes. In those situations, hand sanitizer doesn't help. Thankfully here it seems that COVID is responsive to hand sanitizer, so there is that sort of feather in the cap that we can use that also to mitigate spread. But it might be a good idea, you know, patients who have some of these gi symptoms and aren't necessarily displaying the typical or classic COVID symptoms, maybe need to isolate even a little bit further than just their normal social isolation in order to try to prevent spread.That's true. And one I'm just gonna, this is just planting the seed because I need to read more about this. I've got a bunch of articles I need to get through, but there's new evidence coming out that this Prevotella bacteria may be associated with SARS, CoV2 infection, and Prevotella can cause both severe pneumonia and GI tract issues. Which is fascinating to me because one virologist published this really cool article that I, I wouldn't even do it justice trying to explain it, but basically that the virus can infect the Prevotella. And then it can use the Prevotella to replicate the virus and the Prevotella converts it to DNA and blah, blah, blah, maybe one of the reasons why we're getting negative tests. It was that was his theory. So it's a totally moving target.Right. Yeah, I mean, more data gets published every day just enhances our ability to fight us.So I hope everyone enjoyed this. I hope that wasn't too nerdy. But this is a slightly different gut check project where it's just Dr. Akerman and I talking about his particular specialty and my specialty. I think that as we go forward if there are other journal articles like this being published, or actually we both have access to pre publication. I think that we should do this on a semi regular basis where we can get in front of this, interpret the data, and then hopefully do some things like we thought about on the fly. We were thinking about how we're going to get over these telemedicine visits, that we can maybe have a, a smell congregate of data where people where I can ask them that maybe we this is the beginning of setting up a possible stent with some sort of anti viral thing. So it's it's discussions like this that sort of peak, the peak the boundaries of out of necessity breeds invention.Yeah, I think the more the more of the discussions happen. The more the gastroenterologist, the pulmonologist, the ear, nose and throat doctors, the primary care doctors, the emergency physicians, you know, the allied health professionals, you know, everyone has this continued discussion. It breeds more ideas and more ways that we can be looking at the problem to try to problem solve.Yeah. So I think that what this particular episode should be called is, you know, COVID 2.5, or COVID 3, share with your doctor. So if you look at this, I think this is very relevant for healthcare professionals to hear and a lot of us are just in over our heads right now with trying to keep up with the expenses of a practice because you can't do your procedures. But if you're doing this, what you can do as a service is like and share this with anybody you would like to but it'd be really interesting if you started sharing these with your doctors now that you're doing telemed and things like that. This way we can get some of this out there and get I'll get the healthcare community out in front of it as well.Yeah I agree and you know, I appreciate you having me on the podcast and and you know, hopefully as more information comes out, we'll be able to discuss it further and disseminate that information to the masses.Absolutely. All right, everybody stay safe. We're going to try and give any information we can practice all the things that Dr. Akerman just said. And if you'd like we both accept telemedicine appointments. More importantly, let's all just get through this together as a country as a world as a world.As a world. Stay safe.Take care everybody.

Probably the last episode of the year. See you in the next! This episode: Fungus living inside plants helps them form partnerships with nitrogen-fixing bacteria! Download Episode (5.9 MB, 8.5 minutes) Show notes: Microbe of the episode: Prevotella intermedia Takeaways Plants are very good at acquiring carbon, but they can often use some help with other nutrients. Many form partnerships with microbes such as nitrogen-fixing bacteria or mycorrhizal fungi that can help gather nutrients from the soil better than the plants' own roots. In this study, legume plants could form a partnership with nitrogen-fixing bacteria in its roots, but a fungus living inside the plant could enhance this partnership even more, increasing the amount of nitrogen acquired and influencing the community of microbes around the plant roots in ways favorable to all partners. Journal Paper: Xie X-G, Zhang F-M, Yang T, Chen Y, Li X-G, Dai C-C. 2019. Endophytic Fungus Drives Nodulation and N2 Fixation Attributable to Specific Root Exudates. mBio 10:e00728-19, /mbio/10/4/mBio.00728-19.atom. Other interesting stories: Diet could affect antibiotic impact on the gut microbiome Feeding gut microbes particular preferred foods can manipulate the community structure   Email questions or comments to bacteriofiles at gmail dot com. Thanks for listening! Subscribe: Apple Podcasts, Google Podcasts, Android, or RSS. Support the show at Patreon, or check out the show at Twitter or Facebook.

There appear to be just two types of people in the world: those who have mostly Bacteroides type bacteria in their gut, and those whose colons are overwhelmingly home to Prevotella species instead.

Food Scientist, Kriben Govender (Honours Degree in Food Science & Technology) and James Shadrach (Honours Degree in Psychology) have a wide-ranging discussion with Citizen Scientist Keith Bell on Microbiome stool testing, strategies to modulate gut bacterial composition for optimal health, epilepsy, gut-brain axis, rain forming bacteria, the importance of viruses, gut centric remedies for anxiety and depression, microbiota - mitochondria interaction, kefir and much more   Bio:    Keith Bell is a citizen scientist particularly interested in gut-brain connection including the gut origin of seizure, underdiagnosed in epilepsy. Published articles include topics such as microbial predisposition, fetal colonization, microbe translocation and vaccine safety. He's founder of Sanitation Circle and 25 year veteran of the recycling industry with interest in sanitation and health. During the 1980s, he was a UNICEF radio spokesperson in Chicago for the annual release of State of the World's Children Report. He believes "Sanitation is Sanity" and that microbial balance is an internal and external environmental issue of the highest order. Keith founded The Gut Club in 2016 to create awareness about the importance of intestinal health to general health and provide support for treatment and prevention of metabolic disease.   Topics discussed:   The Glut Club - the hub of microbiome citizen science Analysis of stool test results Microbiome differences across the world Geography, diet and microbiome diversity Allele Microbiome Stool testing Obesity- Firmicutes and Bacteroidetes The immune response guidance by microbes The function of Peyer’s Patches Vaccine response in high Bacteroides cohort Obesity and Lipopolysaccharides (LPS) Persia the Cradle of Bacteroides Prevotella- Fibre eater Microbiome changes after migration Consequences of a shift from Prevotella to Bacteroides The Gut - Could it be the Environmental Issue of our time The Gut and Epilepsy  Rain Making Bacteria and Fungi (see laboratory experiment) https://youtu.be/SenJud3cHLc CO2 sequestering by microbes Exchange breathing method for seizures Diets for Epilepsy Forum The impact of Metformin on the microbiome Bacteriophages (viruses) and early infancy immunity The River Ganges - bacteriophages Personalised medicine via stool test charts Shifting the gut microbiome Autoimmune and Bacteroides dominance Keto, Paleo, Low carb and Carnivore Diet benefits and flora shift The Microbiome and Mental Health Kriben’s struggle with anxiety and depression Environmental factors that cause depression The Gut-Brain Axis The Impact of Stress on Bifidobacteria and Lactobacilli Lactobacilli, Oxytocin and empathy Oxytocin, autism, eye contact and touch Clostridium, serotonin and tryptophan metabolism Amino Acids neurotransmitter balance and microbes Serotonin Syndrome SSRIs Gut, Brain and Heart connection GAPS Diets- Natasha Campbell McBride Kefir Fermentation time and Lactobacillus domination  Fibre, Butyrate production, oxygen, microbiome modulation The importance of the mucous layer Acacia, Partially Hydrogen Guar Gum- Prebiotics Inulin and bloating Fasting and Microbiome Composition Gut Club Stool Testing Discussion Group https://www.facebook.com/groups/TheGutClubStoolTestDiscussionGroup/ The citizen science of sharing microbiome stool charts Autism and Stool test results Faecal Microbiome Transplants Probiotic enemas Breastfed baby poop- untapped medicine Infant stool History in China Bacteroides dominance The impact of excess Bifidobacteria and Akkermansia Race, Gender and Geography of Microbiome Diversity Microbiome and Mitochondrion interaction The impact of antibiotics on mitochondria and ROS production Keith’s top gut health tip Microbial modulation of Vitamin D Dr Jack Kruse interview - Light and the Microbiome https://podcast.nourishmeorganics.com.au/dr-jack-kruse-on-light-and-the-microbiome Brought to you by:   Nourishme Organics The Gut Health Superstore   Shop Gut Health here:   https://www.nourishmeorganics.com.au/   Use code guthealthgurus for 10% off        Allele Microbiome- Australian Provider of World Leading Metagenomic Whole Genome Stool Testing   Learn more about Metagenomic DNA based Stool Testing:   https://www.allele.com.au/collections/frontpage/products/gut-microbiome-analysis       Connect with Keith Bell   Website- https://thegutclub.org/       Connect with Kriben Govender:    Facebook- https://www.facebook.com/kribengee/ Instagram- https://www.instagram.com/kribengovender/ Youtube- https://www.youtube.com/c/Nourishmeorganics?sub_confirmation=1 Gut Health Gurus Facebook Group: https://www.facebook.com/groups/nourishmeorganics/ Mito Wellness Support Facebook Group: https://www.facebook.com/groups/347845406055631/   Download links                 If you enjoyed this episode and would like to show your support:   1) Please subscribe on Itunes and leave a positive review     Instructions:   - Click this link  https://itunes.apple.com/au/podcast/gut-health-gurus-podcast/id1433882512?mt=2   - Click "View in Itunes" button on the left-hand side - This will open the Itunes app - Click the "Subscribe" button - Click on "Ratings and Reviews" tab - Click on "Write a Review" button   Non-Itunes users can leave a Google Review here: https://goo.gl/9aNP0V     2) Subscribe, like and leave a positive comment on Youtube   https://www.youtube.com/c/Nourishmeorganics?sub_confirmation=1   3) Share your favourite episode on Facebook, Instagram, and Stories 4) Let your friends and family know about this Podcast by email, text, messenger etc   5) Support us on Patreon for as little as $5 per month and get same day, early access to our latest podcasts (typically around 4 to 6 weeks earlier than the general public) https://www.patreon.com/nourishmeorganics     Thank you so much for your support. It means the world to us.

 Autism & Fecal Microbiota Transfer Therapy - MTT - FMT - UpdateJames B. Adams, Ph.D., is a President's Professor at Arizona State University, where he directs the autism/Asperger's research program, though he originally taught chemical and materials engineering there. Dr. Adams also holds a post at the Southwest College of Naturopathic Medicine. He is also the president of the Autism Society of Greater Phoenix, the co-chair of the Autism Research Institute's scientific advisory committee, and has received the Autism Service Award from the Greater Phoenix chapter of the Autism Society of America. In this episode, he reports on microbiota transfer therapy. This CBJ/301 is a republication of CBJ/214 and is selected because it reveals a most interesting development in Autism Treatment directly related to gut microbiota and his research with FMTT Fecal Microbiota Transfer Therapy. Must listen! Photo by https://unsplash.com/photos/4zgiTS_qT1k?utm_source=unsplash&utm_medium=referral&utm_content=creditCopyText (Artak Petrosyan) on https://unsplash.com/search/photos/maps?utm_source=unsplash&utm_medium=referral&utm_content=creditCopyText (Unsplash) Reference Details For MTT: Article AbstractMicrobiota Transfer Therapy alters the gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study. Publication Microbiome - Jan. 23, 2017 Author(s) Dae-Wook Kang, James B. Adams, Ann C. Gregory, Thomas Borody, Lauren Chittick5,15, Alessio Fasano, Alexander Khoruts, Elizabeth Geis, Juan Maldonado, Sharon McDonough-Means, Elena L. Pollard, Simon Roux, Michael J. Sadowsky, Karen Schwarzberg Lipson, Matthew B. Sullivan, J. Gregory Caporaso and Rosa Krajmalnik-Brown BackgroundAutism spectrum disorders (ASD) are complex neurobiological disorders that impair social interactions and communication and lead to restricted, repetitive, and stereotyped patterns of behavior, interests, and activities. The causes of these disorders remain poorly understood, but gut microbiota, the 1013 bacteria in the human intestines, have been implicated because children with ASD often suffer gastrointestinal (GI) problems that correlate with ASD severity. Several previous studies have reported abnormal gut bacteria in children with ASD. The gut microbiome-ASD connection has been tested in a mouse model of ASD, where the microbiome was mechanistically linked to abnormal metabolites and behavior. Similarly, a study of children with ASD found that oral non-absorbable antibiotic treatment improved GI and ASD symptoms, albeit temporarily. Here, a small open-label clinical trial evaluated the impact of Microbiota Transfer Therapy (MTT) on gut microbiota composition and GI and ASD symptoms of 18 ASD-diagnosed children. ResultsMTT involved a 2-week antibiotic treatment, a bowel cleanse, and then an extended fecal microbiota transplant (FMT) using a high initial dose followed by daily and lower maintenance doses for 7–8 weeks. The Gastrointestinal Symptom Rating Scale revealed an approximately 80% reduction of GI symptoms at the end of treatment, including significant improvements in symptoms of constipation, diarrhea, indigestion, and abdominal pain. ConclusionsThis exploratory, extended-duration treatment protocol thus appears to be a promising approach to alter the gut microbiome and virome and improve GI and behavioral symptoms of ASD. Improvements in GI symptoms, ASD symptoms, and the microbiome all persisted for at least 8 weeks after treatment ended, suggesting a long-term impact. Similarly, clinical assessments showed that behavioral ASD symptoms improved significantly and remained improved 8 weeks after treatment ended. Bacterial and phagedeep sequencing analyses revealed successful partial engraftment of donor microbiota and beneficial changes in the gut environment. Specifically, overall bacterial diversity and the abundance of Bifidobacterium, Prevotella, and Desulfovibrio among other taxa...

Sommes-nous vraiment maîtres de nos corps alors que nous sommes les hôtes de millions, ou plutôt, de milliards d’organismes ? Vous ne vous en doutez peut-être pas mais nous sommes tous les propriétaires d’un énorme appartement, accueillant en son sein d’innombrables locataires, certains les bienvenus, d’autres indésirables. Cette géante colocation nous accompagne depuis notre naissance jusqu’à la fin de notre vie. Toujours présente en nous, elle participe à une fonction essentielle et complexe de notre quotidien : la digestion. Les noms de ces occupants ? Prevotella ou bacteroides, appartenant tous…

 Autism & Fecal Microbiota Transfer Therapy - MTT - FMT - UpdateJames B. Adams, Ph.D., is a President's Professor at Arizona State University, where he directs the autism/Asperger's research program, though he originally taught chemical and materials engineering there. Dr. Adams also holds a post at the Southwest College of Naturopathic Medicine. He is also the president of the Autism Society of Greater Phoenix, the co-chair of the Autism Research Institute's scientific advisory committee, and has received the Autism Service Award from the Greater Phoenix chapter of the Autism Society of America. This CBJ/214 reveals a most interesting development in Autism Treatment directly related to gut microbiota and his research with FMTT Fecal Microbiota Transfer Therapy. Must listen! Photo by https://unsplash.com/photos/4zgiTS_qT1k?utm_source=unsplash&utm_medium=referral&utm_content=creditCopyText (Artak Petrosyan) on https://unsplash.com/search/photos/maps?utm_source=unsplash&utm_medium=referral&utm_content=creditCopyText (Unsplash) Reference Details For MTT: Article AbstractMicrobiota Transfer Therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study. Publication Microbiome - Jan. 23, 2017 Author(s) Dae-Wook Kang, James B. Adams, Ann C. Gregory, Thomas Borody, Lauren Chittick5,15, Alessio Fasano, Alexander Khoruts, Elizabeth Geis, Juan Maldonado, Sharon McDonough-Means, Elena L. Pollard, Simon Roux, Michael J. Sadowsky, Karen Schwarzberg Lipson, Matthew B. Sullivan, J. Gregory Caporaso and Rosa Krajmalnik-Brown BackgroundAutism spectrum disorders (ASD) are complex neurobiological disorders that impair social interactions and communication and lead to restricted, repetitive, and stereotyped patterns of behavior, interests, and activities. The causes of these disorders remain poorly understood, but gut microbiota, the 1013 bacteria in the human intestines, have been implicated because children with ASD often suffer gastrointestinal (GI) problems that correlate with ASD severity. Several previous studies have reported abnormal gut bacteria in children with ASD. The gut microbiome-ASD connection has been tested in a mouse model of ASD, where the microbiome was mechanistically linked to abnormal metabolites and behavior. Similarly, a study of children with ASD found that oral non-absorbable antibiotic treatment improved GI and ASD symptoms, albeit temporarily. Here, a small open-label clinical trial evaluated the impact of Microbiota Transfer Therapy (MTT) on gut microbiota composition and GI and ASD symptoms of 18 ASD-diagnosed children. ResultsMTT involved a 2-week antibiotic treatment, a bowel cleanse, and then an extended fecal microbiota transplant (FMT) using a high initial dose followed by daily and lower maintenance doses for 7–8 weeks. The Gastrointestinal Symptom Rating Scale revealed an approximately 80% reduction of GI symptoms at the end of treatment, including significant improvements in symptoms of constipation, diarrhea, indigestion, and abdominal pain. ConclusionsThis exploratory, extended-duration treatment protocol thus appears to be a promising approach to alter the gut microbiome and virome and improve GI and behavioral symptoms of ASD. Improvements in GI symptoms, ASD symptoms, and the microbiome all persisted for at least 8 weeks after treatment ended, suggesting a long-term impact. Similarly, clinical assessments showed that behavioral ASD symptoms improved significantly and remained improved 8 weeks after treatment ended. Bacterial and phagedeep sequencing analyses revealed successful partial engraftment of donor microbiota and beneficial changes in the gut environment. Specifically, overall bacterial diversity and the abundance of Bifidobacterium, Prevotella, and Desulfovibrio among other taxa increased following MTT, and these changes persisted after treatment stopped (followed for 8 weeks)....

The Staying Young Show Show Title: “Overcoming Bad Habits” Co-Hosts: Judy Gaman, Walter Gaman Guest: Shannon Kaiser  Segment 1 Today we are going to help you tackle and overcome those bad habits. We all have some habit that we need kick to the curb and some new habits we need to form. Later this hour we're bringing on best-selling author Shannon Kaiser, author of Adventures for your Soul. This lady is not just all over the media including Huffington Post Magazine, Health Magazine, Vogue and on ABC, she was named one of the top 100 Women to Watch in Wellness by Mind, Body Green. Talk about our own bad habits we have had to kick Talk about habits we have kicked over the years Where do we think bad habits come from? Parents, environment, advertising Top 5 bad health habits Setting good goals – does it help? THAT MUSIC MEANS IT'S TIME FOR DOC SHOC. A TIME WHEN WE FIND SOMETHING SHOCKING IN THE NEWS OR WE'RE SHOCKED IT MADE THE NEWS. Multiple sclerosis is an autoimmune disease that causes the individual's immune system to mistakenly attacks myelin - the waxy coating on nerves. Without myelin nerves can't transmit messages between the brain and the rest of the body. Research out of the Mayo Clinic has found that Prevotella histicola, a type of probiotic or gut bacteria, suppresses MS in the mice. In the study, it also increased certain cell types that fight disease, including dendritic cells and T cells. I am excited about this because it could mean the cure too many inflammatory immune diseases could be found by curing the gut first. http://www.medicalnewstoday.com/articles/318855.php TAKE THE SURVEY!!!! Stay Young America.com Facebook (Stay Young Media Group), website (Stayyoungamerica.com, and iTunes, call us 844-well 100 Follow us on Twitter @StayYoungMedia. When we come back, our special guest best-selling author Shannon Kaiser will talk to us about her book Adventures for the Soul and what we can do to break those bad habits. Segment 2 IMMORTAL MINUTE – “This Immortal Minute is brought to you by Solis Mammography “Exceptional Service with Exceptionally Accurate Results” So excited to have Sannon Kaiser on with us. She has appeared in the Huffington Post, Chicken Soup for the Soul, Vogue, ABC, Women's Health, and more, but today she's right here on the Staying Young Show! Tell us the story behind the story. What inspired you to write Adventures for Your Soul: 21 Ways to Transform Your Habits and Reach Your Full Potential? (roundtable) Why do you think people cling to their bad health habits (smoking, drinking, etc.) In the book you talk about how we break up with our issues – explain that What does it mean to play truth or dare with our inner child? Why do we measure ourselves on comparison?   TAKE THE SURVEY!!!!   www.stayyoungamerica.com SHOUT OUT TO MILITARY, Facebook (stay young media group) , download podcasts – follow us on twitter @StayYoungMedia coming up - Coming up – Are you allowing fears to dictate your fate?  Segment 3 Today's show is all about replacing bad habits with good goals. We can't break those habits if we don't know what's causing them. Our guest today is best-selling author Shannon Kaiser and we're talking about her latest book Adventures of the Soul: 21 ways to transform your Habits and Reach Your Full Potential. How did you come up with the 21 habits for the book? What habit do you think is the most effective and why? What is the best piece of advice you have ever been given? What do you believe are the biggest mental blocks that keep us from achieving our goals? (fear detox) Judy tease DD – grab a pen! 844-well100. Podcasts itunes, stayyoungamerica.com Coming up – Medical Mania trivia. Your chance to check your medical knowledge. Segment 4 –   Tease DD 844-Well100 – If you're just tuning in, This whole hour is about breaking bad habits. If you're just tuning in, catch this and every episode on iTunes under Staying Young Show 2.0 or follow us on TWITTTER @StayYoungMedia Medical Mania Trivia – Joy from Irving Texas  1.) Who listens with only half their brain – men or women? A. Men -left side of the brain & women -both sides of the brain. 2.) What percentage of your oxygen and caloric intake are used by your brain? 5, 17, or 20 A. 20% 3.) What is the hardest bone in the body? A. Jaw bone 4.) How many muscles in the body? 100, 235, or 600 or more A. 600 5.) Can a newborn baby cry real tears? A. not until the first three to six weeks. Open discussion DEMENTIA DEFENDER -THIS DEMENTIA DEFENDER IS BROUGHT TO YOU BY SMART NEW YOU AND DR. CHARLES POWELL. IF YOU HAVE SLEEP APNEA AND YOU'RE READY TO DITCH YOUR C-PAP MACHINE CALL 214-524-6333. A little girl kicks a soccer ball. It goes 10 feet and comes back to her. How is this possible?  Thank you for listening to the Stay Young Radio Show! With all the mixed messages on health, you need information that you can use and that you can trust. Listen in as the experts discuss all topics health related. It's time to STAY YOUNG and stay healthy! Each week we tackle a topic and often with leading scientists, best-selling authors, and even your favorite celebrities! As a listener of our show, your input is important to us. Please take a moment to fill out this quick survey so we can serve you better - https://survey.libsyn.com/stayingyoung2 For more information on The Staying Young Show, please visit our website at www.StayYoungAmerica.com, and subscribe to the show in iTunes, Stitcher, or your favorite podcast app. You can also reach out to our host, Judy Gaman on www.judygaman.com for book purchasing, and speaking opportunities in your area!  

Lauren Petersen, PhD, is a postdoctoral associate investigating the microbiome and she’s back on the podcast to update us on her research. Be sure to listen to our first interview first! I sent Lauren some of the probiotics we use in our practice, and she said, “they look great!” Lauren did some calculations for the number of CFUs, and she got pretty much exactly what the bottle claims for live organisms, with growth on both Lactobacillus-selective and Bifidobacterium-selective medias. The same was not true for Renew probiotics where her qPCR analysis showed that Bifidobacterium was pretty much all dead. Here are some photos of the Lactobacillus-selective and Bifidobacterium-selective plates that Lauren used to grow the probiotics. She shot for 250 CFUs per plate (based on if all the organisms per gramme probiotic were alive) and that's pretty much what she got! Sign up for our Highlights email and every week we’ll send you a short (but sweet) email containing the following: One piece of simple, actionable advice to improve your health and performance, including the reference(s) to back it up. One item we read or saw in the health and fitness world recently that we would like to give a different perspective on, and why. One awesome thing that we think you’ll enjoy! Here’s the outline of this interview with Lauren Petersen, PhD: [00:00:32] Previous episode: The Athlete Microbiome Project: The Search for the Golden Microbiome. [00:03:10] Prevotella. [00:04:42] uBiome and The American Gut Project. [00:05:25] Scher, Jose U., et al. "Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis." Elife 2 (2013): e01202. [00:06:33] Probiotics: S. boulardii. [00:08:48] Bifidobacteria. [00:09:54] Testing probiotics: Renew Life. [00:12:06] D-Lactate Free Bifido Probiotic. [00:12:28] Sign up for our highlights email. [00:14:44] qPCR analysis definitely picked up lactobacillus. [00:15:33] 16S vs qPCR. [00:16:03] RNA-Seq. [00:17:20] Whole-genome shotgun. [00:18:26] 60-day Bionic Fiber Program. [00:19:11] Brummel & Brown 35% Vegetable Oil Spread with Yogurt + bananas. I’m not linking to this rubbish because it’s not fit for human consumption. [00:21:25] Akkamansia. [00:21:49] Remely, Marlene, et al. "Increased gut microbiota diversity and abundance of Faecalibacterium prausnitzii and Akkermansia after fasting: a pilot study." Wiener klinische Wochenschrift 127.9-10 (2015): 394-398. [00:24:41] Tolerating inulin. [00:25:22] Celeriac root. [00:26:19] Where do the microbes come from? [00:28:33] Antibiotics. [00:29:09] Cephalexin antibiotic. [00:29:56] Clindamycin antibiotic. [00:32:08] Amoxicillin antibiotic. [00:33:54] Metabolic endotoxaemia. [00:39:28] Mother Dirt. [00:41:42] FMT and the Taymount Clinic. [00:42:17] 4-Cresol Vancomycin.

Lauren Petersen, PhD, is a postdoctoral associate working for Dr. George Weinstock and investigating the microbiome. Our knowledge of the 100 trillion microorganisms that inhabit the human body is still very limited, but the advent of next-generation sequencing technology has allowed researchers to start understanding what kind of microorganisms inhabit the human body and identifying the types of genes these organisms carry. As part of the NIH-funded Human Microbiome Project, her lab is focused on developing and applying the latest technologies to characterize the microbiome and its impact on human health. One of her main projects is metatranscriptomic analysis whereby they are attempting to characterize gene expression of an entire community from human samples such as stool and saliva. Gaining information on what signals or environmental factors can trigger changes in global gene expression of an entire microbial community may provide us with the tools to better treat certain types of diseases in humans. Lauren is currently working on the Athlete Microbiome Project. By collecting stool and saliva samples from a cohort of highly fit professional cyclists, she will make an attempt to understand how their microbiomes may differ from those of the general population. The goal is to characterize the species present, the genes they carry, and how gene expression is modulated in athletes who push their bodies to the limit. Here’s the outline of this interview with Lauren Petersen: [00:00:28] George Weinstock, PhD. [00:01:27] Jeremy Powers interview. [00:01:43] Jeff Kendall-Weed. [00:02:15] Why care about the gut microbiome? [00:03:32] Metabolic functions. [00:03:51] NIH Human Microbiome Project. [00:04:39] Phase II longitudinal study. [00:06:01] Microbial diversity. [00:07:33] Lyme and antibiotics. [00:08:15] Chronic Fatigue Syndrome. [00:09:35] Gordon conferences - Rob Knight. [00:10:27] American Gut Project. [00:10:48] Firmicutes and Bacteroidetes. [00:11:05] Enterobacteriaceae. [00:11:59] Fecal transplant. [00:13:16] Screening donors. [00:13:32] DIY. [00:13:52] C. diff. [00:14:14] Transplants started in the 50s. [00:14:47] IBS. [00:16:12] Healthy donor. [00:17:43] Within a month, Lauren was feeling a lot better. [00:18:13] Instantaneous improvement on the bike. [00:19:22] No more stomach issues, "more energy than I knew what to do with". [00:19:54] Retest data showed perfect match with donor. [00:20:56] Sequencing large vs. small intestinal microbes. [00:21:28] FDA has no idea what to do. [00:23:02] Strategies for maintaining a healthy gut microbiome. [00:23:31] Whole foods, lots of fruit and vegetables. [00:23:48] No gels. [00:24:26] Athlete Microbiome Project. [00:26:34] Microbiome doping? [00:27:05] Ruminococcus - starch digester. [00:28:26] Enterotype - the dominate species in the gut. [00:28:56] Prevotella. [00:30:14] Teasing apart the cause and the effect. [00:32:28] Endotoxins released during intense exercise. [00:32:49] 25 participants at the time of recording, I'm number 26! [00:33:29] Matching cohort of healthy controls. [00:34:28] Ibis World Cup racer. [00:35:01] uBiome. [00:35:08] My app. [00:35:54] The problem with 16S sequencing. [00:36:16] Missing bifidobacteria. [00:37:05] A combination of methods is required for accurate testing. [00:38:30] New commercially available test? [00:39:11] Probiotic quality. [00:40:04] Testing probiotics. [00:41:37] Bifido doesn't like oxygen (or your stomach). [00:42:02] Lactobacillus is more resilient. [00:42:50] Bifido love fructooligosaccharides. [00:43:36] Lack of association with dietary restrictions. [00:44:53] Feed your microbiome!

There are many ancient herbal therapies that are often ignored that could bring much needed pain relief and reduced swelling for people struggling with arthritis. Dave shares with Mark Alyn on Late Night Health five ways to mitigate arthritis with ancient herbal remedies. Approximately 2.1 million Americans suffer from rheumatoid arthritis but new research published at the Mayo Clinic could help doctors better predict and prevent it from occurring. Scientists have discovered that the bacterium in your gut has more responsibilities than just breaking down food. In fact, intestinal microbiota and metabolic 
signatures could help scientists build a predictive 
profile for who is likely to develop rheumatoid arthritis and the exact course the disease will take on the body. “Rheumatoid arthritis is an autoimmune disorder that occurs when the body mistakenly attacks itself,” said David Foreman, known as “The Herbal Pharmacist,” who started his career as a registered pharmacist with a strong belief in natural medicine and uses his expertise in physiology, pharmacology and natural medicine to educate consumers on cutting edge approaches to natural health and healing. “It not only breaks down tissues around joints, causing swelling that can erode bone and cause deformity, but the disease can also damage the skin, eyes, heart, lung and blood vessels.” Connecting the dots between gut microbiota and 
rheumatoid arthritis could help millions of Americans
 who currently suffer from this debilitating disorder. A
 paper published in Arthritis and Rheumatology
 reported that the presence of bacterium Prevotella 
histicola in the gut decreased symptom frequency and
 severity with fewer inflammatory conditions 
associated with rheumatoid arthritis. The bacteria used
 as a treatment produced fewer side effects such as
 weight gain and villous atrophy (a condition that
 prevents the gut from absorbing nutrients). Scientists 
say continued research, especially on humans, could
 lead to preventative treatments, but in the meantime
 Foreman says there are many ancient herbal therapies that are often ignored that could bring much needed pain relief and reduced swelling for people struggling with arthritis. Dave shares with Mark Alyn on Late Night Health five ways to mitigate arthritis with ancient herbal remedies. air date: 8/5/16

There are many ancient herbal therapies that are often ignored that could bring much needed pain relief and reduced swelling for people struggling with arthritis. Dave shares with Mark Alyn on Late Night Health five ways to mitigate arthritis with ancient herbal remedies. Approximately 2.1 million Americans suffer from rheumatoid arthritis but new research published at the Mayo Clinic could help doctors better predict and prevent it from occurring. Scientists have discovered that the bacterium in your gut has more responsibilities than just breaking down food. In fact, intestinal microbiota and metabolic 
signatures could help scientists build a predictive 
profile for who is likely to develop rheumatoid arthritis and the exact course the disease will take on the body. “Rheumatoid arthritis is an autoimmune disorder that occurs when the body mistakenly attacks itself,” said David Foreman, known as “The Herbal Pharmacist,” who started his career as a registered pharmacist with a strong belief in natural medicine and uses his expertise in physiology, pharmacology and natural medicine to educate consumers on cutting edge approaches to natural health and healing. “It not only breaks down tissues around joints, causing swelling that can erode bone and cause deformity, but the disease can also damage the skin, eyes, heart, lung and blood vessels.” Connecting the dots between gut microbiota and 
rheumatoid arthritis could help millions of Americans
 who currently suffer from this debilitating disorder. A
 paper published in Arthritis and Rheumatology
 reported that the presence of bacterium Prevotella 
histicola in the gut decreased symptom frequency and
 severity with fewer inflammatory conditions 
associated with rheumatoid arthritis. The bacteria used
 as a treatment produced fewer side effects such as
 weight gain and villous atrophy (a condition that
 prevents the gut from absorbing nutrients). Scientists 
say continued research, especially on humans, could
 lead to preventative treatments, but in the meantime
 Foreman says there are many ancient herbal therapies that are often ignored that could bring much needed pain relief and reduced swelling for people struggling with arthritis. Dave shares with Mark Alyn on Late Night Health five ways to mitigate arthritis with ancient herbal remedies.

There are many ancient herbal therapies that are often ignored that could bring much needed pain relief and reduced swelling for people struggling with arthritis. Dave shares with Mark Alyn on Late Night Health five ways to mitigate arthritis with ancient herbal remedies.Approximately 2.1 million Americans suffer from rheumatoid arthritis but new research published at the Mayo Clinic could help doctors better predict and prevent it from occurring.Scientists have discovered that the bacterium in your gut has more responsibilities than just breaking down food. In fact, intestinal microbiota and metabolic 
signatures could help scientists build a predictive 
profile for who is likely to develop rheumatoid arthritis and the exact course the disease will take on the body.“Rheumatoid arthritis is an autoimmune disorder that occurs when the body mistakenly attacks itself,” said David Foreman, known as “The Herbal Pharmacist,” who started his career as a registered pharmacist with a strong belief in natural medicine and uses his expertise in physiology, pharmacology and natural medicine to educate consumers on cutting edge approaches to natural health and healing. “It not only breaks down tissues around joints, causing swelling that can erode bone and cause deformity, but the disease can also damage the skin, eyes, heart, lung and blood vessels.”Connecting the dots between gut microbiota and 
rheumatoid arthritis could help millions of Americans
 who currently suffer from this debilitating disorder. A
 paper published in Arthritis and Rheumatology
 reported that the presence of bacterium Prevotella 
histicola in the gut decreased symptom frequency and
 severity with fewer inflammatory conditions 
associated with rheumatoid arthritis. The bacteria used
 as a treatment produced fewer side effects such as
 weight gain and villous atrophy (a condition that
 prevents the gut from absorbing nutrients).Scientists 
say continued research, especially on humans, could
 lead to preventative treatments, but in the meantime
 Foreman says there are many ancient herbal therapies that are often ignored that could bring much needed pain relief and reduced swelling for people struggling with arthritis. Dave shares with Mark Alyn on Late Night Health five ways to mitigate arthritis with ancient herbal remedies.

There are many ancient herbal therapies that are often ignored that could bring much needed pain relief and reduced swelling for people struggling with arthritis. Dave shares with Mark Alyn on Late Night Health five ways to mitigate arthritis with ancient herbal remedies.Approximately 2.1 million Americans suffer from rheumatoid arthritis but new research published at the Mayo Clinic could help doctors better predict and prevent it from occurring.Scientists have discovered that the bacterium in your gut has more responsibilities than just breaking down food. In fact, intestinal microbiota and metabolic 
signatures could help scientists build a predictive 
profile for who is likely to develop rheumatoid arthritis and the exact course the disease will take on the body.“Rheumatoid arthritis is an autoimmune disorder that occurs when the body mistakenly attacks itself,” said David Foreman, known as “The Herbal Pharmacist,” who started his career as a registered pharmacist with a strong belief in natural medicine and uses his expertise in physiology, pharmacology and natural medicine to educate consumers on cutting edge approaches to natural health and healing. “It not only breaks down tissues around joints, causing swelling that can erode bone and cause deformity, but the disease can also damage the skin, eyes, heart, lung and blood vessels.”Connecting the dots between gut microbiota and 
rheumatoid arthritis could help millions of Americans
 who currently suffer from this debilitating disorder. A
 paper published in Arthritis and Rheumatology
 reported that the presence of bacterium Prevotella 
histicola in the gut decreased symptom frequency and
 severity with fewer inflammatory conditions 
associated with rheumatoid arthritis. The bacteria used
 as a treatment produced fewer side effects such as
 weight gain and villous atrophy (a condition that
 prevents the gut from absorbing nutrients).Scientists 
say continued research, especially on humans, could
 lead to preventative treatments, but in the meantime
 Foreman says there are many ancient herbal therapies that are often ignored that could bring much needed pain relief and reduced swelling for people struggling with arthritis. Dave shares with Mark Alyn on Late Night Health five ways to mitigate arthritis with ancient herbal remedies.air date: 8/5/16

In episode 64 of MicrobeWorld Video, Dr. Stan Maloy talks with Anne Tanner Ph.D., BDS, MDCH (Hon.), Associate Professor at Harvard School of Dental Medicine about her research into dental caries and the oral microbiome. This episode was filmed at the American Association for the Advancement of Science Meeting in Vancouver, Canada on February 18th, 2012. Anne's work with Streptococcus mutans, the leading know cause of Early Childhood Caries (ECC), has led to the discovery of a new bacterium, Scardovia Wiggsiae. This discovery was the result of using modern molecular techniques combined with traditional anaerobic culture methods perfected in the practice of periodontology. Anne is now working with this new bacterium to see if it's a caries pathogen. Anne discusses the role probiotics have played in the treatment and prevention of dental caries. She is optimistic that these good bacteria can be effective in the battle against harmful oral bacterium. Finally, Anne talks about being one of only a few people who has more than one microbe (Prevotella Tannerae and Tannerella forsythia) named after her.

In episode 64 of MicrobeWorld Video, Dr. Stan Maloy talks with Anne Tanner Ph.D., BDS, MDCH (Hon.), Associate Professor at Harvard School of Dental Medicine about her research into dental caries and the oral microbiome. This episode was filmed at the American Association for the Advancement of Science Meeting in Vancouver, Canada on February 18th, 2012. Anne's work with Streptococcus mutans, the leading know cause of Early Childhood Caries (ECC), has led to the discovery of a new bacterium, Scardovia Wiggsiae. This discovery was the result of using modern molecular techniques combined with traditional anaerobic culture methods perfected in the practice of periodontology. Anne is now working with this new bacterium to see if it's a caries pathogen. Anne discusses the role probiotics have played in the treatment and prevention of dental caries. She is optimistic that these good bacteria can be effective in the battle against harmful oral bacterium. Finally, Anne talks about being one of only a few people who has more than one microbe (Prevotella Tannerae and Tannerella forsythia) named after her.

In episode 64 of MicrobeWorld Video, Dr. Stan Maloy talks with Anne Tanner Ph.D., BDS, MDCH (Hon.), Associate Professor at Harvard School of Dental Medicine about her research into dental caries and the oral microbiome. This episode was filmed at the American Association for the Advancement of Science Meeting in Vancouver, Canada on February 18th, 2012. Anne's work with Streptococcus mutans, the leading know cause of Early Childhood Caries (ECC), has led to the discovery of a new bacterium, Scardovia Wiggsiae. This discovery was the result of using modern molecular techniques combined with traditional anaerobic culture methods perfected in the practice of periodontology. Anne is now working with this new bacterium to see if it's a caries pathogen. Anne discusses the role probiotics have played in the treatment and prevention of dental caries. She is optimistic that these good bacteria can be effective in the battle against harmful oral bacterium. Finally, Anne talks about being one of only a few people who has more than one microbe (Prevotella Tannerae and Tannerella forsythia) named after her.

Überprüfung der Wirksamkeit stallspezifischer Vakzinen zur Bekämpfung der Dermatitis digitalis bei Milchkühen Die Studie wurde als kontrollierter Doppelblindversuch durchgeführt. Die Untersuchungen fanden in einem Milchviehbetrieb in Norddeutschland statt (429 Tiere bei der ersten Untersuchung). Aus den Hautbioptaten typischer DD-Läsionen wurden folgende Erreger im anaeroben Bereich isoliert: Porphyromonas ssp., Porphyromonas levii, Porphyromonas endodonatales, Fusobacterium necrophorum, Bac. stercoris, Prevotella bivis, Peptostreptococcus indolicus, Treponema sp.. Daraus wurden zwei formalininaktivierte Adsorbatvakzinen hergestellt. Die eine enthielt alle Keimarten außer Treponema sp. (Impfgruppe A), die andere alle Keimarten und Treponema sp. (Keimanteil 20 %) aus einer Schüttelkulturvermehrung (Impfgruppe B). Als Placebo wurde die Impflösung ohne Antigen verwendet (Kontrollgruppe). Verabreicht wurden je 5 ml Impfstoff oder Placebo subkutan. Der Klauengesundheitsstatus wurde im Oktober 1998, März 1999, Oktober 1999 und im Januar 2000 im Rahmen der halbjährlich durchgeführten funktionellen Klauenpflege erfasst und die Befunde der Hintergliedmaßen dokumentiert. Die erste Impfung erfolgte im Dezember 1998, die zweite drei Wochen später, die weiteren Impfungen fanden im März 1999 und im November 1999 statt. Zwischen der ersten und vierten Untersuchung durchgeführte Klauen- und Antibiotikabehandlungen wurden vom Betriebsleiter protokolliert. Die Auswertung erbrachte folgende Ergebnisse: 1. Zu keinem der vier Untersuchungszeitpunkte bestanden signifikante Unterschiede bezüglich der Prävalenzen der DD in den zwei Impfgruppen und der Kontrollgruppe. Die Prävalenzen der DD bewegten sich zum Zeitpunkt der vier Untersuchungen um 36 %, 42 %, 51 % und 38 %. 2. An Hintergliedmaßen, die bei der Erstuntersuchung DD-Läsionen aufwiesen, konnten auch bei den Folgeuntersuchungen in den zwei Impfgruppen und der Kontrollgruppe jeweils etwa gleichhäufig derartige Veränderungen diagnostiziert werden. 3. An Hintergliedmaßen, die bei der Erstuntersuchung frei von DD waren, konnten bei den Folgeuntersuchungen in den zwei Impfgruppen und der Kontrollgruppe jeweils etwa gleichhäufig DD-Läsionen diagnostiziert werden. 4. Die Scorewerte (nach DÖPFER, 1994) DD positiver Tiere - als Maßzahl für den Schweregrad der DD-Veränderung - waren zu den vier Untersuchungszeitpunkten in den zwei Impfgruppen und der Kontrollgruppe statistisch nicht signifikant verschieden. 5. Der „maximale gewichtete Flächenindex (max. GFI)“ - als weitere Bewertungsgrundlage für den Schweregrad der DD - war bei den Untersuchungen U2 und U3 in den Impfgruppen und der Kontrollgruppe nicht statistisch signifikant verschieden. Bei U1 war in der Impfgruppe B ein statistisch signifikant höherer Mittelwert (x) festzustellen als in der Kontrollgruppe (x = 82; p = 0,006). Bei U4 war in der Kontrollgruppe ein statistisch signifikant niedrigerer Mittelwert (x) festzustellen als in den Impfgruppen (x = 22,5; p = 0,033). 6. Die Häufigkeit von Klauen- und Antibiotikabehandlungen sowie der Einfluss von DD-Läsionen auf die Abgangsursache waren in den zwei Impfgruppen und der Kontrollgruppe statistisch nicht signifikant verschieden. In der vorliegenden Impfstudie konnte weder eine prophylaktische noch eine therapeutische Wirkung durch die verwendeten stallspezifischen Vakzinen bei der Bekämpfung der Dermatitis digitalis festgestellt werden. Auch das Hinzufügen von Treponema sp. erbrachte keinen Effekt auf die Wirksamkeit des Impfstoffs.