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Send us a textAging, tissue repair, and the longevity benefits of psilocin.Episode Summary: Dr. Louise Hecker discusses her research on tissue repair and regeneration, explaining how fibroblasts drive wound healing by forming scar tissue but fail to resolve properly with age, leading to fibrotic diseases like pulmonary fibrosis and liver cirrhosis; they discuss aging hallmarks such as oxidative stress and telomere shortening, and highlight Hecker's study showing psilocybin's active metabolite, psilocin, extends cellular lifespan in lab cultures by reducing oxidants and preserving telomeres, while monthly doses in aged mice improved appearance and survival rates.About the guest: Louise Hecker, PhD is an Associate Professor of Medicine at Baylor College of Medicine, specializing in repair and regeneration processes, particularly in aging and fibrotic diseases.Discussion Points:Fibroblasts are dormant cells that activate during injury to pull wounds closed and form scars, then de-differentiate or die; aging impairs this, causing persistent scarring and disease.Aging reduces the body's regenerative capacity; different organs vary in repair efficiency, with skin healing better than heart tissue.Oxidative stress, like "rust" in the body, accumulates with age due to imbalanced reactive oxygen species production and antioxidant defenses, contributing to cellular damage.Telomeres act as protective DNA caps that shorten with cell divisions, serving as a hallmark of biological aging; sirtuins are master regulators influencing aging processes.Hecker's in vitro study showed psilocin dose-dependently extended fibroblast lifespan by 29-50%, lowering oxidative stress below young cell levels and preserving telomeres.In aged mice (equivalent to 60-65 human years), monthly high-dose psilocybin (15 mg/kg) led to healthier appearance, regrown fur, and 80% survival when controls reached 50% mortality after 10 months.Psilocybin's effects may stem from serotonin receptors expressed in many cell types beyond the brain, suggesting broader anti-aging potential; future work explores mechanisms, optimal dosing, and applications for age-related diseases.Fungi like magic mushrooms represent an under-explored "kingdom" for medicine, with psilocybin's durable effects hinting at systemic impacts on aging.Reference Paper:Study: Psilocybin treatment extends cellular lifespan and improves survival of aged miceRelated content:Support the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. For all the ways you can support my efforts

Send us a textThe effects of protein restriction on metabolism, liver hormones, brain, and behavior.Episode Summary: Dr. Christopher Morrison talks about how animals sense and prioritize nutrients like protein, discussing defense mechanisms for essentials such as oxygen, water, sodium, and energy; the brain's role in detecting protein deprivation via signals like FGF21; trade-offs between growth, reproduction, and longevity under protein restriction; and reconciling high-protein diets for satiety and muscle maintenance with low-protein benefits for metabolic health and lifespan extension.About the guest: Christopher Morrison, PhD is a professor and researcher at the Pennington Biomedical Research Center in Baton Rouge, Louisiana, where he has worked for over 22 years focusing on nutrition, metabolism, and chronic diseases like obesity and diabetes.Discussion Points:The body prioritizes nutrients hierarchically: oxygen and water first, then sodium, energy, and protein, with weaker defenses for carbs or fats.Animals develop specific appetites for deprived nutrients, like salt or protein, often through post-ingestive learning rather than just taste.Protein restriction (e.g., 5% vs. 20% in diets) increases food intake and energy expenditure in mice to maintain protein levels, even at the cost of extra calories.FGF21, a liver hormone, signals protein deprivation to the brain (via NTS region), driving protein-seeking behavior and metabolic changes; it's essential for low-protein responses.Protein restriction extends lifespan in lab animals by suppressing growth signals like IGF-1 and mTOR, but may impair immunity or wound healing in real-world conditions.High protein aids satiety, weight loss, and muscle building, but overconsumption may shorten lifespan; optimal intake depends on age, activity, and goals (e.g., not for pregnant or elderly).No one-size-fits-all for protein: mild restriction may benefit middle-aged sedentary people for health, while athletes need more; balance avoids excesses.Related content:M&M 106: Diet, Macronutrients, Micronutrients, Taste, Whole vs. Processed Food, Obesity & Weight Loss, Comparative Biology of Feeding Behavior | Stephen Simpson & David Raubenheimer*Not medical advice.Support the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. For all the ways you can support my efforts

Episode Summary Dr. Stephanie Peacock interviews Natalie Golba, co-founder of The Healthiest Chef, about making plant-based eating accessible for busy professionals. Natalie shares her transformation story and practical strategies for incorporating 42 different plants into your weekly diet without spending hours in the kitchen. Guest Bio Natalie Golba is a Harvard-trained plant-based chef and co-founder of The Healthiest Chef. After struggling with unexplained weight gain for three years despite working with trainers and nutritionists, she discovered the power of whole food nutrition and now helps others make sustainable dietary changes. Key Topics The Healthiest Chef Program - A comprehensive nutrition education platform for busy professionals featuring expert interviews and practical cooking instruction that teaches 2-hour weekly meal prep. Personal Journey - Natalie's 3-year struggle with weight gain and her partner Irina's lifelong digestive issues led them to create solutions for others facing similar challenges. Client Transformations - Weight loss, digestive healing, increased energy, and most notably, complete cooking beginners becoming creative recipe developers. Meal Prep Strategy - Start with one simple meal like overnight oats (15 minutes for 3 days), gradually add a weekly soup, focus on plant diversity over complicated macro counting. Recipe Development - Each recipe goes through 3-20 iterations to ensure flavors are "10 times better than processed food" for long-term sustainability. Upcoming Projects Detox Program - Launching after July 4th with Dr. Stephanie Peacock, featuring easy meal prep and a free nontoxic masterclass. Future Vision - Specialized nutrition programs for cancer and cardiovascular patients to support medical treatment. Resources The Healthiest Chef: healthiestchef.com Follow: @NatalieGolba and @DrStephPeacock for detox program updates

Send us a textCellular clean up by immune cells and how early-life fructose exposure leads to neurodevelopmental problems.Episode Summary: Dr. Justin Perry talks about the body's constant cellular turnover—about 3 million cells die per second in adults (double in children and women)—handled by phagocytes like macrophages that engulf and digest debris to prevent diseases like lupus. They explore phagocytosis steps, macrophage adaptations in tissues like the brain (microglia), and how high fructose intake impairs microglial function in developing mice, leading to uncleared brain cells and anxiety-like behaviors, with implications for human neurodevelopmental disorders amid rising fructose consumption.About the guest: Justin Perry, PhD is an immunologist and clinical psychologist who leads a lab at Memorial Sloan Kettering Cancer Center focusing on how the body clears dead cells and debris to maintain homeostasis.Discussion Points:The body turns over 1-2% of its 30 trillion cells daily, mostly blood cells, but neurons in kids and endometrium in women turnover at ~2x this ratePhagocytosis involves "find me," "eat me," and digestion signals; failures can cause autoimmunity.Microglia are brain macrophages that uptake fructose via GLUT5 transporter.Early high fructose exposure (comparable to one soda daily) impairs the pruning of synapses and dead neurons.In mice, prenatal or postnatal fructose causes phagocytosis deficits in the prefrontal cortex, leading to heightened fear responses and poor fear extinction, mimicking anxiety disorders.Fructose correlates with rising neurodevelopmental issues like autism and anxiety; it's passed via breast milk, and liquid forms (e.g., sodas) overwhelm metabolic shields more than solid fruits.Macrophages may hold keys to diseases from atherosclerosis to cancer; deleting GLUT5 in microglia reverses fructose's effects, hinting at evolutionary roles in aging or low-oxygen states.Related content:M&M 215: Cancer Metabolism: Sugar, Fructose, Lipids & Fasting | Gary PattiArticle | Dietary Fructose & Metabolic Health: An Evolutionary PerspectiveReference Paper:Study | Early life high fructose impairs microglial phagocytosis and neurodevelopment*Not medical advice.Support the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. For all the ways you can support my efforts

Send us a textThe potential link between acetaminophen (Tylenol) and autism, with a surprise phone call from RFK partway through.Episode Summary: Dr. William Parker talks about autism spectrum disorder (ASD), its rising prevalence since the 1980s, and the controversial hypothesis that acetaminophen exposure in susceptible infants and children triggers most cases via oxidative stress. They discuss ASD's clinical definition; historical misconceptions like the "refrigerator mother" theory; genetic susceptibilities; acetaminophen's metabolism, which produces toxic byproducts in underdeveloped livers, leading to brain effects.About the guest: William Parker, PhD spent nearly 30 years as a professor at Duke University researching underlying causes of chronic conditions, including discovering the immune function of the human appendix and pioneering studies on immune systems in wild animals.Discussion Points:Autism is a spectrum disorder with core symptoms like social deficits, repetitive behaviors, and aversion to new stimuli.Parker argues overwhelming evidence points to acetaminophen as the primary trigger in susceptible individuals, causing oxidative stress via toxic metabolite NAPQI.Acetaminophen, marketed as Tylenol or paracetamol, was not tested for neurodevelopmental effects in neonatal animals until 2014, despite widespread use since 1886; it's metabolized differently in babies, whose livers lack mature detox pathways.Susceptibility factors include low glutathione (an antioxidant), poor sulfation/glucuronidation metabolism, folate receptor autoantibodies, and events like immune reactions that prompt acetaminophen use during oxidative stress.Regressive autism, where children lose milestones after seeming normal, often follows acetaminophen given for fevers or illnesses, explaining parental vaccine suspicions (as shots coincide with drug use).Adult acetaminophen is generally safe but causes liver toxicity in overdoses or with alcohol; antidote is NAC to boost glutathione.Parker has suggested to policymakers that we should avoid acetaminophen during pregnancy, birth, and early childhood (under age 3-5); parents should plan ahead for fevers/pain without it, but seek medical help for unusual symptoms.*Not medical advice.Support the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. For all the ways you can support my efforts

Send us a textThe appendix's hidden role and how "good" parasites like helminths shape immune health.Episode Summary: Dr. William Parker discusses gut anatomy, the appendix's role in harboring beneficial bacterial biofilms and immune tissue, and how modern hygiene depletes helminths (intestinal worms), causing immune overreactions like allergies, autoimmunity, and psychiatric conditions. He explores helminth self-therapy for treating relapsing MS, depression, and allergies; challenges in clinical trials due to patent issues; and why COVID-19 was milder in low-income, helminth-rich regions.About the guest: William Parker, PhD conducted research at Duke University for over 27 years on immunology, appendicitis, and the hygiene hypothesis. After retiring from Duke, he serves as a visiting scholar at the University of North Carolina at Chapel Hill, leading efforts on biome reconstitution via helminths.Discussion Points:Appendix is not vestigial; it concentrates immune tissue and biofilms to cultivate good gut bacteria, preventing pathogens via mucus and IgA antibodies.Hygiene hypothesis: Soap, toilets, and clean water reduce helminths/protozoa, leading to untrained, hyperactive immunity and rising allergies/autoimmunity since the 1800s.Helminths (worms) stimulate immune "exercise," training immunity; biohackers use hookworms (cheap, skin-entry), porcine whipworms, or rat tapeworms orally for relief from allergies, MS flares, depression/anxiety.Effects are temporary; need ongoing exposure (e.g., replenish every 6 months); immigrants from helminth-rich areas develop Western diseases within a few years.COVID-19: Hyper-immunity caused severe reactions in hygienic West, but helminth presence in low-income Africa/Asia prevented cytokine storms, leading to empty clinics.Therapy barriers: Non-patentable organisms require $100M+ trials; push for open-source, government-funded biome restoration over crude immunosuppressants.Related episode:M&M 144: Inflammation, Innate Immunity, Allergies & Allergens, Immune System Evolution, Fasting & Metabolism | Clare Bryant*Not medical advice.Support the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. For all the ways you can support my efforts

Send us a textWhat is the core evolved function of the endocannabinoid system?Episode Summary: Dr. Giovanni Marsicano is a neuroscientist based in Bordeaux, France, where he leads a research group at INSERM focusing on the endocannabinoid system.About the guest: Giovanni Marsicano, PhD discusses the endocannabinoid system, starting with its core components like CB1 receptors and lipid-based molecules derived from omega-6 fatty acids; its cellular signaling, evolutionary role in energy storage for uncertain futures (exostasis vs. homeostasis); effects across tissues; motivation, appetite, pain relief, and anxiety regulation; biphasic effects of cannabinoids.Discussion Points:The endocannabinoid system acts as an "exostatic" regulator, promoting energy accumulation for future needs by enhancing food palatability, nutrient absorption, and fat storage, unlike "endostatic" systems that address immediate hunger.CB1 receptors appear in vertebrates with adipose tissue, suggesting an evolutionary link to storing fat for survival in unstable environments.Endocannabinoids are lipids from omega-6 fats; high intake boosts their levels, potentially fueling obesity by creating a self-perpetuating cycle of overeating.Activation of CB1 can have biphasic effects due to receptors on different cell types like excitatory vs. inhibitory neurons.Pregnenolone, a steroid precursor, acts as a natural CB1 inhibitor to prevent excessive activation, blocking harmful effects like psychosis from high THC doses.The system influences motivation beyond food, including sex and even human activities like sports or storytelling, by rewarding actions for potential future benefits.In the brain, CB1 on mitochondria and astrocytes modulates energy use, olfaction, and social stress transmission, with implications for disorders like Alzheimer's.Reference Paper:CB1 Receptor as the Cornerstone of ExostasisRelated episode:M&M 123: EndocanSupport the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. AquaTru: Reverse osmosis water filters. Remove metals, microbes, endocrine disruptors and toxins from drinking water. $100 off AquaTru filters through link. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. MASA Chips—delicious tortilla chips made from organic corn & grass-fed beef tallow. No seed oils or artificial ingredients. Code MIND for 20% off For all the ways you can support my efforts

Send us a textHow brain synapses work and fuel themselves with fat.Episode Summary: Dr. Timothy Ryan talks about the high energy costs of synapses, the role of mitochondria and glycolysis, and challenge the long-held view that the brain relies solely on glucose by discussing new evidence that neurons burn fats from lipid droplets for fuel, especially during activity. The talk touches on metabolic flexibility, links to epilepsy treatments like ketogenic diets, neurodegenerative diseases, and future research on brain energy sources.About the guest: Timothy Ryan, PhD is a professor of biochemistry at Cornell University. His research focuses on the molecular mechanisms of synaptic transmission, particularly vesicle recycling and the bioenergetics that power neural communication. Discussion Points:Synapses are tiny structures with ~100 vesicles per site (on average), converting electrical signals to chemical ones.Brain tissue is energy-hungry due to trillions of synapses (in humans), relying on local mitochondria (present in only ~half of synapses) and glycolysis.Vesicles use proton pumps and transporters to concentrate neurotransmitters, requiring ATP to maintain gradients.Neurons are metabolically fragile; cutting fuel supply quickly impairs synapses.Dogma held brains don't burn fats, but new work shows neurons form lipid droplets (fat stores) that are invisible because constantly used for energy via beta-oxidation.Silencing neurons builds lipid droplets like resting muscle; activity speeds their breakdown, indicating demand-driven fat use.Inhibiting neuron-specific fat-processing enzymes accumulates droplets and induces torpor (hibernation-like state) in animals, signaling metabolic stress.Ketogenic diets aid epilepsy by shifting to ketones; fats may explain this, with potential ties to aging and neurodegeneration like Alzheimer's.Brain may be a "hybrid" fuel user (glucose + fats), with open questions on fat sources and roles in cognition or disease protection.Related episode:M&M 158: Ketosis & Ketogenic Diet: Brain & Mental Health, Metabolism, Diet & Exercise, Cancer, Diabetes | Dominic D'Agostino*Not medical advice.Support the showAll episodes, show notes, transcripts, and more at the M&M Substack Affiliates: KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off Readwise: Organize and share what you read. 60 days FREE through link SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. MASA Chips—delicious tortilla chips made from organic corn & grass-fed beef tallow. No seed oils or artificial ingredients. Code MIND for 20% off For all the ways you can support my efforts

Send us a textThe genetics of sleep duration and sleep timing.Episode Summary: Dr. Ying-Hui Fu discusses her research on the genetics of sleep, focusing on natural short sleepers who thrive on 4-6 hours of sleep and the heritability of sleep traits like duration and timing. She explores how sleep efficiency, rather than just duration, may explain why some need less sleep without health deficits, and delves into the molecular and circadian mechanisms regulating sleep. About the guest: Ying-Hui Fu, PhD is a neuroscientist and professor at UCSF, where her lab studies the genetics of human sleep behaviors, particularly sleep duration and schedule.Discussion Points:Sleep Traits Are Genetic: Sleep duration (how long you sleep) and sleep schedule (when you sleep) are partially heritable, with most people needing 7-9 hours, while rare natural short sleepers thrive on 4-6 hours.Natural Short Sleepers: These individuals fall asleep quickly, have high sleep efficiency, and live healthy, active lives without deficits, possibly due to faster toxin clearance and repair during sleep.Sleep Efficiency Matters: Short sleepers may complete restorative sleep processes (e.g., clearing toxins, repairing damage) more efficiently, allowing them to need less sleep.Circadian & Entrainment Pathways: Sleep timing is regulated by a molecular clock and environmental cues like light, with mutations in entrainment pathways causing extreme schedules (e.g., early bedtime or night owl tendencies).Modern Lifestyle Harms Sleep: Stimuli like blue light and tense media disrupt sleep patterns, leading to widespread sleep deprivation and health risks.Shift Work Risks: Shift workers face higher risks of diseases like cancer and neurodegeneration due to disrupted sleep cycles, though genetic background influences susceptibility.Finding Your Sleep Rhythm: A two-week vacation without stimulants or artificial light can help determine your natural sleep schedule and duration.Sleep's Health Impact: Poor sleep is a major factor in aging and diseases like Alzheimer's, making it as critical as diet and exercise for health.Related episode:M&M 237: Circadian Biology: Genetics, Behavior, Metabolism, Light, OxygenSupport the showAll episodes, show notes, transcripts, and more at the M&M Substack Affiliates: KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off Readwise: Organize and share what you read. 60 days FREE through link SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. MASA Chips—delicious tortilla chips made from organic corn & grass-fed beef tallow. No seed oils or artificial ingredients. Code MIND for 20% off For all the ways you can support my efforts

Send us a textA blend of biology, philosophy, and history exploring how hormones and endocrine disruptors affect social behavior and society.Episode Summary: Dr. Charles Cornish-Dale discusses the decline of masculinity in modern society, linking it to falling testosterone levels, environmental endocrine disruptors, and the limitations of liberal democracy. Drawing on Francis Fukuyama's “End of History & the Last Men” and historical perspectives, Cornish-Dale argues that biological and societal factors, including diet and hormonal interventions like birth control, are reshaping male and female behaviors, with profound implications for health and social structures.About the guest: Charles Cornish-Dale, PhD is a medieval historian and anthropologist with a PhD from Oxford. His new book is, “The Last Men: Liberalism and the Death of Masculinity.”Discussion Points:Thymos & Masculinity: Cornish-Dale uses the ancient Greek concept of thymos, meaning spiritedness, to explain male drives for recognition and distinction, which he ties to testosterone-driven behaviors.Testosterone Decline: Studies like the Massachusetts Male Aging Study show a ~20% drop in male testosterone levels over 17 years, correlating with reduced reproductive health and social withdrawal.Endocrine Disruptors: Chemicals in plastics, pesticides, and soy products mimic estrogen, disrupting hormonal balance and potentially causing developmental and behavioral issues.Diet & Behavior: Historical shifts to grain-based diets, as noted by Plato, and modern plant-based trends may suppress thymos and alter hormonal profiles, impacting societal dynamics.Hormonal Contraceptives: Birth control can thin the ventromedial prefrontal cortex in women, affecting emotional regulation, especially if taken during teenage years, with potential permanent effects.Fukuyama's End of History Framework: Cornish-Dale critiques liberal democracy's inability to satisfy megalothymia (the desire to be better), contributing to a crisis of purpose for men.Related episode:M&M 193: History of Diet & Food, Population Density & Social Stability, Psychological Pandemics, Physical & Mental Health in Civilizational CyclesSupport the showAll episodes, show notes, transcripts, and more at the M&M Substack Affiliates: KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off Readwise: Organize and share what you read. 60 days FREE through link SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. MASA Chips—delicious tortilla chips made from organic corn & grass-fed beef tallow. No seed oils or artificial ingredients. Code MIND for 20% off For all the ways you can support my efforts

Send us a textHow our biological clocks shape biology from the molecular to behavioral level.Episode Summary: Dr. Joseph Takahashi discusses circadian rhythms, exploring their biological basis, from molecular mechanisms to their impact on metabolism and health; the discovery of circadian clock genes; role of the suprachiasmatic nucleus, and how light, feeding, and oxygen influence these rhythms. The conversation highlights practical implications, such as the effects of artificial light and meal timing on health, and touches on emerging research linking stronger circadian clocks to longevity.About the guest: Joseph Takahashi, PhD is a renowned neuroscientist at UT Southwestern Medical Center, where he leads research on circadian clock genes.Discussion Points:The suprachiasmatic nucleus in the hypothalamus acts as the brain's central clock, syncing with light via the retina.Key circadian genes like CLOCK and BMAL regulate thousands of genes, especially those involved in metabolism, impacting health outcomes.Internal desynchronization, when brain and organ clocks misalign (e.g., from eating at night), can lead to metabolic issues like pre-diabetes.In mice, eating at the right time (night for nocturnal animals) extends lifespan by up to 35% under caloric restriction, compared to 10% with spread-out feeding.Artificial light, especially blue light at night, disrupts melatonin and circadian rhythms, while natural sunlight supports healthy eye development.Melatonin, a darkness-signaling hormone, is best for resetting rhythms (e.g., jet lag) at low doses, not as a sedative, and U.S. supplements vary widely in quality.Oxygen-sensing proteins interact with circadian clock components, hinting at links between altitude, metabolism, and health.Learning and memory show diurnal variations, with better performance at certain times, influenced by circadian modulation of synaptic activity.A stronger circadian clock, created genetically in mice, led to 16% longer lifespan and resistance to weight gain (unpublished research).Related episode:M&M 202: Why Do Animals Sleep? | Vlad Vyazovskiy*Not medical advice.Support the showAll episodes, show notes, transcripts, and more at the M&M Substack Affiliates: KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off Readwise: Organize and share what you read. 60 days FREE through link SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. MASA Chips—delicious tortilla chips made from organic corn & grass-fed beef tallow. No seed oils or artificial ingredients. Code MIND for 20% off For all the ways you can support my efforts

Send us a textHow brains compute and learn, blending neuroscience with AI insights.Episode Summary: Dr. Marius Pachitariu discusses how the brain computes information across scales, from single neurons to complex networks, using mice to study visual learning. He explains the differences between supervised and unsupervised learning, the brain's high-dimensional processing, and how it compares to artificial neural networks like large language models. The conversation also covers experimental techniques, such as calcium imaging, and the role of reward prediction errors in learning.About the guest: Marius Pachitariu, PhD is a group leader at the Janelia Research Campus, leading a lab focused on neuroscience with a blend of experimental and computational approaches.Discussion Points:The brain operates at multiple scales, with single neurons acting as computational units and networks creating complex, high-dimensional computations.Pachitariu's lab uses advanced tools like calcium imaging to record from tens of thousands of neurons simultaneously in mice.Unsupervised learning allows mice to form visual memories of environments without rewards, speeding up task learning later.Brain activity during sleep or anesthesia is highly correlated, unlike the high-dimensional, less predictable patterns during wakefulness.The brain expands sensory input dimensionality (e.g., from retina to visual cortex) to simplify complex computations, a principle also seen in artificial neural networks.Reward prediction errors, driven by dopamine, signal when expectations are violated, aiding learning by updating internal models.Large language models rely on self-supervised learning, predicting next words, but lack the forward-modeling reasoning humans excel at.Related episode:M&M 44: Consciousness, Perception, Hallucinations, Selfhood, Neuroscience, Psychedelics & "Being You" | Anil Seth*Not medical advice.Support the showAll episodes, show notes, transcripts, and more at the M&M Substack Affiliates: KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off Readwise: Organize and share what you read. 60 days FREE through link SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. MASA Chips—delicious tortilla chips made from organic corn & grass-fed beef tallow. No seed oils or artificial ingredients. Code MIND for 20% off For all the ways you can support my efforts

Send us a textHow dietary fats and cannabinoids shape brain function and mental well-being.Episode Summary: Dr. Steven Laviolette discusses the role of lipids, particularly endocannabinoids and fatty acids, in brain signaling and mental health, discussing how dietary omega-3 and omega-6 imbalances, prenatal THC exposure, and fatty acid binding proteins (FABPs) impact mood, anxiety, and neuroinflammation, while highlighting potential dietary interventions to mitigate these effects.About the guest: Steven Laviolette, PhD is a professor at the University of Western Ontario, holding a PhD, and his lab focuses on the brain's cannabinoid system and its role in mental health. He investigates how cannabinoids and fatty acids influence brain development and disorders like anxiety and schizophrenia.Discussion Points:The brain uses fats like endocannabinoids (e.g., anandamide, 2-AG) not just for structure but as signaling molecules to regulate emotional and cognitive processing.Prenatal THC exposure in rodents skews the omega-3/omega-6 balance toward pro-inflammatory omega-6, leading to cognitive and mood issues in offspring, but omega-3 supplementation can mitigate these effects.Fatty acid binding proteins (FABPs), especially FABP5, shuttle endocannabinoids like anandamide to degradation sites, and inhibiting FABP5 increases anandamide levels, reducing anxiety and depression without addictive side effects.FABP5 inhibitors show promise as safer alternatives to benzodiazepines.Both THC and CBD can induce problems during early development, challenging the notion that CBD is universally safe, especially during pregnancy.Dietary interventions, like omega-3 supplementation or antioxidants (e.g., L-theanine, N-acetylcysteine), may counteract the negative psychiatric effects of cannabinoid exposure, particularly during adolescence.The North American diet, high in omega-6, contributes to neuroinflammation and mental health issues, underscoring the need for nutritional neuroscience to address these imbalances.Related episode:M&M 165: PUFAs in Brain Health & Disease, Dietary Fats, Brain Lipids, Nutrition | Richard Bazinet*Not medical advice.Support the showAll episodes, show notes, transcripts, and more at the M&M Substack Affiliates: KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off Readwise: Organize and share what you read. 60 days FREE through link SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. MASA Chips—delicious tortilla chips made from organic corn & grass-fed beef tallow. No seed oils or artificial ingredients. Code MIND for 20% off For all the ways you can support my efforts

Send us a textAre seed oils really driving chronic disease (and sunburns), or is it hype?Episode Summary: Dr. Brian Kerley talks about the health impacts of seed oils, their high omega-6 fatty acid content, and their role in chronic diseases through mechanisms like lipid peroxidation and oxidative stress. They explore how these industrially processed oils may contribute to conditions like heart disease and obesity, discuss the challenges of studying their long-term effects, and highlight the cultural and political dimensions of dietary trends.About the guest: Brian Kerley, MD is a family medicine-trained hospitalist physician who gained online prominence as the "Seed Oil Disrespecter" through his meme account, raising awareness about the health risks of seed oils.Discussion Points:Seed Oils & Health Risks: Seed oils (e.g., soybean, corn, etc.) are high in omega-6 polyunsaturated fatty acids (PUFAs), linked to oxidative stress and lipid peroxidation, producing toxic compounds like 4-HNE and acrolein that damage cells.Evolutionary Perspective: The high omega-6 levels in modern diets are evolutionarily novel, deviating from natural omega-6 to omega-3 ratios found in traditional diets, potentially exacerbating health issues across diverse populations.Challenges with RCTs: Randomized controlled trials (RCTs) often fail to capture the long-term effects of seed oils due to the need for extended washout periods (up to 8 years) and the pervasive presence of omega-6 in modern food environments.Cultural & Political Coding: Dietary trends like seed oil avoidance have become politically charged, with Kerley noting the polarization between institutional health narratives and alternative health communities, complicating public health discussions.Personal Impact: Dr. Kerley's focus on seed oils stems from personal experiences, including managing his daughter's mitochondrial disorder, highlighting the personal stakes in dietary choices.Related episode:M&M 192: Seed Oils, Chronic Disease, Diet & Religious Cults, Mainstream Medicine vs. Independent Research | Tucker Goodrich*Not medical advice.Support the showAll episodes, show notes, transcripts, and more at the M&M Substack Affiliates: KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off Readwise: Organize and share what you read. 60 days FREE through link SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. MASA Chips—delicious tortilla chips made from organic corn & grass-fed beef tallow. No seed oils or artificial ingredients. Code MIND for 20% off For all the ways you can support my efforts

In episode 550 of ADHD reWired, Eric Tivers sits down with Dr. Shannan Palma to explore Decide—a suite of AI-powered decision-support tools built by and for neurodivergent brains. Throughout this conversation, you'll hear about: How Decide leverages AI (Gemini and large language models) to help with everyday choices and multi-step tasks. The story behind IT Assistive Technologies and the Autistic Self-Reliance Support Network. Real-world examples of “decision fatigue” and how Decide's guided and randomized features ease choice paralysis. The balance between AI assistance and human insight—and why a trusting, well-prompted tool can feel like a personal neurodivergent life coach. Pricing, privacy, and the community-focused mission: 85 percent of ITI's profits fund disability-led initiatives. Bonus segments on Pride Month, coaching groups, virtual coworking, and how to get involved with ADHD reWired's summer programs. Use these show notes to get a quick overview, find useful links, and discover why Decide might become your new go-to when you're stuck choosing dinner, figuring out a daily routine, or simply need a gentle “nudge” to move forward. Episode Summary Dr. Shannan Palma—co-founder of Decide and co-director of the Autistic Self-Reliance Support Network—joins Eric to unpack how tools designed by autistic and ADHD adults can transform decision making for all of us. Shannan shares her own late autism and ADHD diagnoses, the challenges she faced finding resources after getting “the piece of paper,” and how a 48-hour hackathon sparked a project that won first prize and secured nearly $400 k in grant funding. From door-dash dilemmas to life-altering choices (like whether to adopt a foster dog), Decide offers two core modes: Randomized Choice Generator Users create custom lists (e.g., favorite restaurants, daily routines) and assign energy costs. The app selects an option based on your current energy level—no more breakfast indecision or “what to watch next” paralysis. Guided Decision Assistance A series of friendly, “affirmative” prompts mirror a real-time coach. By reflecting back your own criteria (energy, resources, priorities), Decide delivers a percentage-confidence recommendation and rationale—so you can make a defensible, informed choice without overthinking. Along the way, Shannan emphasizes the importance of privacy (your data always belongs to you), ethical AI (focusing on “do no harm”), and how Decide's freemium model avoids the “ADHD tax” by offering 10 free guided decisions per month. Premium access is available for $4.99/month, but you can cancel at any time without losing progress. Key Takeaways Why “Decision Fatigue” Matters: Neurodivergent brains often struggle with countless small choices (e.g., “What's for dinner?”). Decide's randomized generator isn't just for fun—it reduces executive-function load by factoring in your energy level and pre-ranked options. Guided Mode = Personalized Neurodivergent Coaching: Instead of writing complex prompts for ChatGPT or Claude, Decide asks you targeted yes/no/unsure questions. Once you answer, it gives a clear recommendation (with a confidence score) plus a brief “why,” so you trust your decision-making process. Built by Autistic + ADHD Makers: After Shannan's late autism diagnosis, she realized few supports existed for lower-visibility autistic adults. A 48-hour hackathon (Give Back Hack Columbus) brought together autistic and ADHD engineers, designers, and researchers—leading to Decide's prototype and subsequent $400 k grant from Ohio's Department of Developmental Disabilities. Community-First Funding Model: 85 percent of any IT Assistive Technologies' profits flow back to the Autistic Self-Reliance Support Network (ASR). ASR focuses on autonomy and resources for autistic adults—rather than caregiver research—aiming to expand capacity and economic inclusion across the lifespan. Privacy & Data Rights: Decide won't train AI on your personal data, and you retain full ownership of anything you input. Future plans include an opt-in research repository for autistic/ADHD lifespan data—governed by community safeguards. Bonus: Pride Month & ADHD ReWired Community Updates: Neurodivergent Pride Panel: Friday, June 13th at 10 AM PT / 1 PM ET (free registration at ). Summer Coaching Groups kick off July 24th—save $200 by joining the registration kickoff on June 18th (more info at ). Adult Study Hall: Virtual coworking with monthly “Pomodoro Dance Parties” (4th Friday, Pride-themed on June 27th). Try a 1-week free trial at . Next Live Q&A: Tuesday, June 10th at 10:30 AM PT / 1:30 PM ET (become a Patron at for behind-the-scenes coaching calls). Resources & Links Decide AI Decision Assistant • Web: • App Store (iOS) & Google Play (Android) • Guided decisions: 10 free/month; Premium: $4.99/month (cancel anytime) Dr. Shannan Palma & IT Assistive Technologies • IT Assistive Technologies (for-profit): • Autistic Self-Reliance Support Network (non-profit): • LinkedIn: (mention you heard the podcast!) Neurodivergent Pride & June Events • Neurodivergent Pride Panel (June 13): • Adult Study Hall Pomodoro Dance Party (June 27): ADHD ReWired Coaching & Community • Summer Coaching Groups (start July 24): • Live Q&A (June 10): RSVP details sent to interest list • Patreon: Books & References • Annie Duke, Thinking in Bets (on decision quality vs. outcome quality) • “Selling Out the Spectrum” by Ryan E. Conviction (autistic journalist on research ethics)

Send us a textThe biophysics of life, exploring how light & energy shape biology, with biophysicist Dr. Nirosha Murugan.Episode Summary: Dr. Murugan discusses the role of biophysics in biology, focusing on how light, particularly biophotons emitted by cells, influences processes like wound healing, neural activity, and cancer detection; how microtubules may act as biological fiber optics, the impact of modern light environments on health; her work inducing limb regeneration in frogs using silk hydrogels and growth factors; cancer as an energetic dysfunction; potential of non-invasive photonic diagnostics; the need for new tools to study these phenomena.About the guest: Nirosha Murugan, PhD is a biophysicist and assistant professor at Wilfrid Laurier University in Waterloo, Ontario. Her lab investigates the biophysics of life.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Transcript and other information on Substack.Key Conversation Points:Cells emit biophotons, ultra-weak light tied to metabolism, which may carry information for processes like immune response and neural communication.Microtubules might function as biological fiber optics, potentially guiding light within cells for signaling purposes.Red and near-infrared light can accelerate wound healing and reduce inflammation, likely by modulating mitochondrial activity.Cancer cells emit distinct photonic signatures, which could enable non-invasive diagnostics by detecting light differences from healthy tissues.Modern light environments, unlike natural sunlight, may subtly affect health by altering biological responses to electromagnetic signals.Biological systems act as metamaterials, patterning energy flow in ways that constrain and shape molecular and behavioral outcomes.Related episode:M&M 221: Regenerative Energy & the Light Inside You | Jack Kruse*Not medical advice.Support the showAll episodes, show notes, transcripts, and more at the M&M Substack Affiliates: KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off Readwise: Organize and share what you read. 60 days FREE through link Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off For all the ways you can support my efforts

Send us a textShort Summary: Dr. Alex Kwan unpacks the latest neuroscience research on how psychedelics like ketamine & psilocybin reshape the brain.About the guest: Alex Kwan, PhD, is an associate professor of biomedical engineering at Cornell University. His lab employs advanced imaging to study how psychedelics and other drugs affect the mammalian brain.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Transcript and other information on Substack.Episode Summary: Dr. Alex Kwan discusses how psychedelics like ketamine and psilocybin induce rapid neuroplastic changes in the brain, particularly in the prefrontal cortex, contrasting their effects with traditional antidepressants like SSRIs, and exploring their potential for treating depression and chronic pain through structural and functional brain alterations.Key Takeaways:Ketamine & psilocybin rapidly increase dendritic spine density in the prefrontal cortex, enhancing neural connections within days, unlike SSRIs, which take weeks.These drugs show sustained neuroplastic changes in mice, lasting weeks to months after a single dose, suggesting long-term brain rewiring.Serotonin 2A receptor is critical for psilocybin's neuroplastic effects, as precise genetic knockouts in adult mice eliminate spine growth.Unlike ketamine, psilocybin activates the insula, a brain region linked to chronic pain processing, hinting at new therapeutic potential.Both drugs induce similar gene expression patterns in areas like the prefrontal cortex and amygdala, but differ in specific regions like the insula.Related episode:M&M #30: Psilocybin, Ketamine, Neuroplasticity & Imaging the Brain | Alex Kwan*Not medical advice.Support the showAll episodes, show notes, transcripts, and more at the M&M Substack Affiliates: KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off Readwise: Organize and share what you read. 60 days FREE through link Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off For all the ways you can support my efforts

Send us a textShort Summary: The flaws of nutrition epidemiology with Dr. John SpeakmanAbout the guest: John Speakman, PhD is a professor at the University of Aberdeen and runs a lab in Shenzhen, China, focusing on energy balance, obesity, and aging. Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Transcript and other information on Substack.Episode Summary: Dr. John Speakman explores the pitfalls of nutrition epidemiology, a field that links diet to health outcomes like cancer and obesity but often produces contradictory results. They discuss flawed methods like 24-hour recalls and food frequency questionnaires, which rely on memory and are prone to bias, and introduce Speakman's new tool using doubly labeled water to screen implausible dietary data. The conversation highlights systematic biases, such as under-reporting by heavier individuals, and emerging technologies like photo diaries and AI for better dietary tracking.Key Takeaways:Nutrition epidemiology studies often contradict each other due to unreliable methods.Common techniques like 24-hour recalls & food frequency questionnaires suffer from memory issues, portion size issues, and systematic biases, often underestimating food intake.Heavier individuals (higher BMI) under-report food intake more, skewing associations between diet & obesity.Speakman's tool, based on 6,500 doubly labeled water measurements, predicts energy expenditure to flag implausible dietary survey data.Emerging technologies, like smartphone photo diaries and AI food identification, promise more accurate dietary tracking than traditional surveys.Randomized controlled trials, not surveys, provide the most reliable dietary insights; single-day intake surveys linked to outcomes years later are dubious.Speakman advises ignoring most nutrition epidemiology headlines due to their inconsistency and lack of prognostic value for behavior change.Related episode:Support the showAll episodes, show notes, transcripts, etc. at the M&M Substack Affiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Readwise: Organize and share what you read. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. For all the ways you can support my efforts

Send us a textShort Summary: Cancer's metabolic roots with Dr. Thomas Seyfried.About the guest: Thomas Seyfried, PhD is a professor of biology at Boston College. He has researched cancer metabolism, epilepsy, and lipid biochemistry for over 40 years.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Transcript and other information on Substack.Episode Summary: Dr. Thomas Seyfried discusses the mitochondrial metabolic theory of cancer, challenging the dominant somatic mutation theory. He explores how cancer cells rely on fermentation due to defective oxidative phosphorylation, drawing on Otto Warburg's work. Seyfried explains how ketogenic diets and nutritional ketosis can starve cancer cells by limiting glucose and glutamine, while sharing evidence from nuclear transfer experiments and clinical studies. The conversation also covers environmental factors driving cancer and the importance of metabolic flexibility for prevention.Key Takeaways:Cancer is characterized by dysregulated cell growth, but Seyfried argues it stems from mitochondrial dysfunction, not just genetic mutations.Cancer cells ferment glucose & glutamine, unable to use fatty acids or ketones, making ketogenic diets a potential therapeutic tool.Nuclear transfer experiments show cancer traits reside in the cytoplasm, not the nucleus, challenging the somatic mutation theory.Environmental factors like processed foods, stress, and poor sleep disrupt mitochondrial function, increasing cancer risk.Seyfried's glucose-ketone index helps monitor metabolic states to manage cancer & chronic diseases.Cancer rates are rising in younger people, possibly due to obesity, inflammation, and environmental toxins.Metabolic flexibility, cycling between ketosis and carb-based states, may mimic ancestral patterns and reduce chronic disease risk.Related episode:M&M #215: Cancer Metabolism: Sugar, Fructose, Lipids & Fasting | Gary PattiSupport the showAll episodes, show notes, transcripts, etc. at the M&M Substack Affiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Readwise: Organize and share what you read. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. For all the ways you can support my efforts

Send us a textShort Summary: Heart health and the ketogenic diet, with expert insights from a cardiologist and researcher.About the guest: Matthew Budoff, MD, is a preventive cardiologist and professor of medicine at UCLA School of Medicine.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Transcript and other information on Substack.Episode Summary: Dr. Matthew Budoff discusses cholesterol, heart disease, and his study on the ketogenic diet's impact on lean, metabolically healthy individuals with high LDL cholesterol. He explains LDL, HDL, and triglycerides, debunking myths about their direct link to heart disease, and emphasizes the importance of coronary calcium scans to assess plaque buildup. Budoff also covers statins, dietary cholesterol, and personalized heart health strategies.Key Takeaways:LDL cholesterol is not a definitive predictor of heart disease; plaque buildup, assessed via coronary calcium scans, is a better indicator.Lean metabolically healthy people on a ketogenic diet may have high LDL without increased plaque progression after one year.Coronary calcium scans, costing ~$100, are recommended for men around age 40 and women around 45-50 to evaluate heart disease risk.Statins effectively lower LDL and can reverse soft plaque, but may be overprescribed for those without plaque buildup.Dietary cholesterol has minimal impact on blood cholesterol, as the liver produces ~85% of it.Ketogenic diet can aid weight loss & diabetes control but may cause high LDL in some lean individuals, known as lean mass hyper-responders.Plaque progression depends more on existing plaque than LDL levels in metabolically healthy ketogenic diet followers.Heart health varies widely due to genetics and other unknown factors, underscoring the need for personalized assessments.Related episode:M&M #158: Ketosis & Ketogenic Diet: Brain & Mental Health, Metabolism, Diet & Exercise, Cancer, Diabetes | Dominic D'AgoSupport the showAll episodes, show notes, transcripts, etc. at the M&M Substack Affiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Readwise: Organize and share what you read. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. For all the ways you can support my efforts

Send us a textShort Summary: A mind-bending dive into evolutionary biology and health through a biophysicist's lens, with Dr. Jack Kruse delivering provocative insights about biology, medicine, and health.About the guest: Jack Kruse, MD, is a neurosurgeon known for integrating biophysics into medicine. He challenges conventional biochemistry with his “leptin prescription” and decentralized health approach.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Full transcript and other information on Substack.Episode Summary: Dr. Jack Kruse joins host Nick Jikomes to explore the Great Oxygenation Event's role in shaping life, linking it to modern health via biophysics over biochemistry. They discuss oxygen's impact on metabolism, the significance of deuterium-depleted water, and sunlight's influence on the leptin-melanocortin pathway. Kruse shares his dramatic weight loss journey using sunlight and cold therapy, critiques modern tech-driven obesity, and unveils a controversial history of SV40 in vaccines, tying it to cancer spikes.Key Takeaways:The Great Oxygenation Event (2.1-2.4 billion years ago) drove life's shift to oxygen-based metabolism, with cyanobacteria as key players.Kruse argues biophysics, not biochemistry, explains evolution, spotlighting light as life's fundamental driver.Deuterium-depleted water is important for enabling our cells and mitochondria to use energy from the TCA cycle without “shocking” the body.Sunlight exposure boosts nitric oxide, reducing food needs via the leptin pathway, challenging diet norms.Kruse lost 133 pounds in 11 months using sunlight and cold therapy, inspiring his “leptin prescription.”He links obesity to indoor tech lifestyles, disrupting heme proteins and mitochondrial function.SV40, a virus in 1950s polio vaccines, may connect to cancer rises, a story Kruse says was buried by centralized science.Related episode:M&M #196: Vaccine Contamination & Fiat Science Support the showAll episodes, show notes, transcripts, etc. at the M&M Substack Affiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Readwise: Organize and share what you read. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. For all the ways you can support my efforts

Send us a textShort Summary: A deep dive into the science of oxidative stress, antioxidants, aging, and neurodegenerative diseases like Alzheimer's.About the guest: Pamela Maher, PhD is a professor at the Salk Institute in San Diego, California, with a focus on neurodegenerative diseases, oxidative stress, and antioxidants.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Full transcript and other information on Substack.Episode Summary: Dr. Pamela Maher discusses her research on cell death mechanisms, including apoptosis and ferroptosis, and their roles in health and disease. They discuss how oxidative stress from reactive oxygen species can damage cells, the body's antioxidant defenses like glutathione and studies on natural compounds—fisetin, curcumin, and cannabinol (CBN)—that may protect against brain cell loss. The conversation covers CBN's mitochondrial benefits in aging mouse models and broader risk factors for dementia, like obesity and hearing loss, emphasizing early intervention.Key Takeaways:Apoptosis is a controlled cell death process vital for development, while ferroptosis, linked to oxidative stress and iron, causes cells to burst and is tied to diseases like Alzheimer's.Oxidative stress arises when reactive oxygen species overwhelm antioxidants, damaging DNA, proteins, and cell membranes, especially polyunsaturated fats.Glutathione, a key antioxidant, relies on cysteine and declines with age, but supplements like N-acetylcysteine might help, though tolerability varies.Cannabinol (CBN), a THC byproduct, protects mitochondria and improves memory in aging mice, hinting at therapeutic potential beyond cannabinoid receptors.Middle-age risk factors like visceral obesity, type 2 diabetes, and hearing loss significantly increase dementia risk, but hearing aids can reduce it.Related episode:M&M #165: PUFAs in Brain Health & Disease, Dietary Fats, Brain Lipids, Nutrition | Richard Bazinet*Not medical aSupport the showAll episodes, show notes, transcripts, etc. at the M&M Substack Affiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Readwise: Organize and share what you read. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. For all the ways you can support my efforts

Send us a textShort Summary: A detailed examination of shamanism with anthropologist Manvir Singh, blending evolutionary theory and vivid storytelling.About the guest: Manvir Singh, PhD is an anthropologist at the University of California, Davis. His new book, "Shamanism: The Timeless Religion," comes out on May 25, 2025.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Full transcript and other information on Substack.Episode Summary: Dr. Manvir Singh discusses shamanism's role as a universal human practice, exploring its roots in cultural evolution, cognitive tendencies, and persistence across history and modern society. They discuss how shamans use altered states to address uncertainty—like healing or divination—while examining shamanism's interplay with centralized religion, its psychological benefits, and parallels in today's world, from tech gurus to medical placebos.Key Takeaways:Shamanism is a widespread cultural practice involving specialists who enter altered states to engage with unseen forces, often for healing or managing uncertainty.It's not an archaic precursor to modern religion but a recurring expression of spiritual beliefs & practices, competing with other forms.Techniques vary widely—dance, music, psychedelics—but only about half of shamans historically used psychoactive substances.Modern parallels include tech CEOs and money managers who project exceptionalism to influence others, echoing shamanic charisma without trance.Open-label placebos (where patients know it's fake) still work, suggesting rituals alone can trigger healing, much like shamanic practices.Singh sees shamanism as a cognitive technology, not inherently good or bad, shaping how we cope with chaos across cultures and time.Related episode:M&M #86: Shamanism, Psychedelics, Social Behavior, Religion & Evolution of Human Culture | Michael Winkelman*Not medical advice.Support the showAll episodes, show notes, transcripts, etc. at the M&M Substack Affiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Readwise: Organize and share what you read. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. For all the ways you can support my efforts

Send us a textShort Summary: How environmental chemical exposures affect neurodegenerative disease and health.About the guest: Gary Miller, PhD is a Professor of Environmental Health Sciences at Columbia University. His research bridges pharmacology, toxicology, and neuroscience to explore neurodegeneration, particularly Parkinson's and Alzheimer's diseases.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Full transcript and other information on Substack.Episode Summary: Dr. Gary Miller talks about neurodegenerative diseases like Parkinson's and Alzheimer's, exploring their age-driven nature, early detection challenges, and environmental risk factors such as pesticide exposure and head trauma. They discuss the emerging field of exposomics—studying lifetime chemical exposures—and its potential to uncover links between pollutants, diet, and disease, while highlighting protective factors like caffeine and nicotine, and the role of technology in advancing prevention and treatment.Key Takeaways:Neurodegenerative diseases like Parkinson's & Alzheimer's worsen with age, but early intervention could slow progression & improve quality of life.Parkinson's symptoms often appear after significant dopamine neuron loss, but subtle signs like handwriting changes or gait issues might be detectable earlier.Environmental factors, including pesticides & air pollution, increase neurodegeneration risk, while caffeine and nicotine surprisingly lower Parkinson's incidence.The exposome—total lifetime exposure to chemicals—offers a new lens to study health, revealing how pollutants & diet interact with our biology.Ultra-processed foods & common chemicals like PFAS (in packaging) raise exposure levels, but simple steps like air filters or less processed diets can help reduce risks.Related episode:M&M #145: Epigenetics, Hormones, Endocrine Disruptors, Microplastics, Xenoestrogens, Obesogens & Obesity, Inheritance of ASupport the showAll episodes, show notes, transcripts, etc. at the M&M Substack Affiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Readwise: Organize and share what you read. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. For all the ways you can support my efforts

Send us a textShort Summary: Insider's look at the COVID-19 pandemic response from a seasoned epidemiologist, unraveling myths and lessons with straightforward science.About the guest: Martin Kulldorff, PhD is an epidemiologist and biostatistician with decades of experience in infectious disease monitoring and vaccine safety. He was formerly a professor at Harvard Medical School. Note: Podcast episodes are fully available to paid subscribers on the M&M Substack. Partial versions are available elsewhere. Full transcript and other information on Substack.Episode Summary: Dr. Martin Kulldorff discusses the COVID pandemic response, reflecting on the controversial Great Barrington Declaration, which opposed lockdowns in favor of protecting the vulnerable. They explore the virus's fatality rates, asymptomatic spread, and vaccine efficacy, contrasting textbook epidemiology with real-world decisions. He critiques institutional failures, like the CDC's misleading claims. He shares optimism for future pandemics with better leadership and public awareness.Key Takeaways:Lockdowns ignored basic public health principles, causing collateral damage like missed cancer screenings, while Sweden's focused protection approach led to lower excess mortality.Early data showed COVID's risk was 1000x higher for older people, yet lockdowns didn't prioritize them, unlike textbook strategies.Asymptomatic spread made containment impossible, unlike Ebola, where isolation works due to clear symptoms.Natural immunity was downplayed despite 2500 years of evidence, leading to wasted vaccines on those already immune.CDC falsely claimed vaccines stopped transmission, eroding trust when people got sick anyway, fueling vaccine skepticism.mRNA vaccine boosters lack proper trials, and their long-term effects need rigorous study, not assumptions.Kulldorff's new Journal of the Academy of Public Health pushes open peer review to rebuild trust in science.Related episode:M&M #100: Infectious Disease, Epidemiology, Pandemics, Health Policy, COVID, Politicization Support the showAll episodes, show notes, transcripts, etc. at the M&M Substack Affiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Readwise: Organize and share what you read. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. For all the ways you can support my efforts

Participant names: Dr. Evan Kalin-Hajdu (host), Dr. Jeffrey A. Nerad (panelist), Dr. David Jordan (panelist), Dr. Robert C. Kersten (panelist) Episode Summary Dr. Evan Kalin-Hajdu hosts this episode of The Oculofacial Podcast. Dr. Kalin-Hajdu is an assistant professor of Ophthalmology at the University of Montreal in the division of Oculofacial Plastic Surgery. The panel includes Dr. Jeffrey A. Nerad, Dr. David Jordan, and Dr. Robert C. Kersten. Dr. Nerad is an Oculofacial Plastic Surgeon in private practice in Cincinnati, Dr. Jordan is a Professor of Ophthalmology at the University of Ottawa in the division of Oculofacial Plastic Surgery, and Dr. Kersten is a Professor of Ophthalmology at the Moran Eye Center at the University of Utah in the division of Oculofacial Plastic Surgery. Drs. Nerad, Jordan and Kersten are icons of the field of Oculofacial Plastic Surgery. Combined, they have nearly 700 peer reviewed publications and an innumerable list of awards, guest speakerships, textbooks, and book chapters. Dr. Kalin-Hajdu engages these three legendary panelists to discuss their most memorable cases. The incredible cases touch subjects ranging from psychiatry to oncology to nutrient deficiencies. Resources: American Society of Ophthalmic Plastic and Reconstructive Surgery (ASOPRS): asoprs.org  Journals and Publications for related case studies, such as Survey of Ophthalmology We invite you to delve into the full episode for these extraordinary and educational case discussions. Stay tuned to the Oculofacial Podcast for more inspiring content and insights from the world of oculoplastic and reconstructive surgery.

Send us a textShort Summary: The complexities of neurodegenerative disease, particularly Alzheimer's, environmental influences like glyphosate, and the crucial role of nutrients like choline, with actionable insights into brain health management.About the guest: Dr. Ramon Valazquez is an Assistant Professor at Arizona State University, leading a research lab at the Neurodegenerative Disease Research Center. His work focuses on environmental factors related to Alzheimer's and other dementias, alongside developing therapeutic strategies.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and to everyone on YouTube. Partial versions are available elsewhere. Full transcript and other information on Substack.Episode Summary: Dr. Ramon Velazquez explores neurodegenerative disease, with a deep dive into Alzheimer's, its pathophysiology including amyloid beta plaques and tau pathology. It examines the controversy around these proteins' roles in disease progression, the influence of environmental toxins like glyphosate on brain health, and the preventive potential of nutritional interventions, particularly choline.Key Takeaways:Neurodegenerative Disease Basics: Alzheimer's disease involves both amyloid beta plaques and tau tangles, with tau pathology more closely linked to clinical symptoms.Environmental Impact: Glyphosate, a common herbicide, can cross into the brain, potentially exacerbating neurodegenerative pathways through inflammation.Choline: Essential for brain function and fat metabolism, it's often deficient in diets, particularly plant-based ones. Adequate intake might prevent or mitigate cognitive decline and related diseases.Preventive Measures: Early nutritional intervention, like maintaining choline levels, could be vital for preventing neurodegenerative diseases. However, once symptoms are present, such interventions might not reverse existing pathology.Related episode:M&M #145: Epigenetics, HormonesSupport the showAll episodes, show notes, transcripts, etc. at the M&M Substack Affiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Readwise: Organize and share what you read. Use your phone's link. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. For all the ways you can support my efforts

Send us a textShort Summary: The science of glycosylation, its impact on health, and potential treatments for congenital disorders of glycosylation (CDGs).About the guest: Dr. Eva Morava is a pediatric geneticist originally from Hungary, who has specialized in inborn errors of metabolism, particularly CDGs. She has a background in pediatrics and genetics from training in Hungary and the U.S., and currently leads the genetics and genomics department at Mount Sinai.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and to everyone on YouTube. Partial versions are available elsewhere.Episode Summary: Dr. Eva Morava discusses the critical role of glycosylation in biology, where sugars are not just used for energy but in modifying proteins to perform their functions. She explains how defects in this process lead to CDGs, a group of rare genetic disorders. The conversation covers the mechanics of glycosylation, clinical presentations of CDGs, current research on treatments including dietary interventions and gene therapy, and the broader implications of glycosylation in health, such as in liver disease and cancer.Key Takeaways:Glycosylation Basics: Sugars are attached to proteins (glycosylation) to modify their structure and function, influencing everything from clotting to immune response.CDGs: These disorders are caused by genetic defects in the glycosylation process, leading to a wide array of symptoms because many proteins require glycosylation to function correctly.Clinical Variability: CDGs can range from severe, multi-systemic presentations to relatively mild cases, affecting life expectancy and quality of life variably.Therapeutic Approaches: Current research includes drug repurposing for enzyme activity enhancement, dietary interventions with special sugars like mannose, and gene therapy, with some trials underway.Liver Connection: A significant portion of glycosylation occurs in the liver; thus, liver diseases like non-alcoholic fatty liver disease can impact glycosylation.*Not medical advice.Support the showAll episodes (audio & video), show notes, transcripts, and more at the M&M Substack Affiliates: MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. Learn all the ways you can support my efforts

Send us a textShort Summary: Deep dive into preventive medicine, personalized nutrition, and systems biology, providing listeners with actionable insights on optimizing health through diet & microbiome management.About the guest: Momo Vuyisich is a biologist with a background in government science, focusing on drug development before shifting to preventive medicine. He holds a PhD in biochemistry and is currently Chief Science Officer of Viome, a startup company dedicated to personalized health through microbiome analysis.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and for free on YouTube. Partial versions are available elsewhere.Episode Summary: Dr. Vuyisich discusses the transformative potential of preventive medicine by drawing parallels between human health and systems biology, particularly through the lens of the gut microbiome. He explains how Viome uses comprehensive testing (stool, blood, saliva), providing personalized dietary and supplement recommendations based on individual physiological data. Covers the complexity of diseases like IBD, the impact of modern lifestyle on our microbiome, and more.Key Takeaways:Disconnection from Nature: Modern lifestyles have disrupted our symbiotic relationship with nature, leading to microbiome degradation through factors like antibiotics, preservatives, and hygiene practices.Personalized Nutrition: Viome's approach involves tailoring food recommendations & supplements to an individual's unique microbiome and physiological needs, highlighting that food impacts can vary greatly between individuals.Testing for Prevention: Regular testing with tools like Viome's full body intelligence test can help in making informed dietary changes to prevent diseases before they manifest.Lifestyle Over Medication: Many chronic conditions can potentially be managed or prevented through lifestyle adjustments rather than lifelong medication, emphasizing the need for a preventive rather than reactive strategy.Related episodes:M&M #178: Microbiome & Gut-Immune InteractionsSupport the showAll episodes (audio & video), show notes, transcripts, and more at the M&M Substack Affiliates: MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. Learn all the ways you can support my efforts

Episode Summary:Dr. Rachel Wheeler joins me today on Holy Heretics to discuss ecospirituality and the practice of rewilding both our life and faith.Let's be honest, Christians have a horrendous relationship with the natural world, best understood through a combination of harmful historical, theological, and cultural influences. Growing up evangelical meant believing the world was bad and, as a result, ecological well-being and the health of the planet were seen as secondary or unimportant compared to “getting saved.” In addition, an overt emphasis on the afterlife as well as a history of colonialism has often led to a devaluation of our earthly home.From a theological perspective, one of the most influential ideas shaping Christian attitudes toward nature is the concept of dominion described in Genesis 1:28, where humans are given authority over the Earth and its creatures. Historically, this idea was interpreted as humans being granted the right to exercise control over nature and exploit its resources. Western Christianity interpreted "dominion" not merely as stewardship but as mastery or ownership over creation. This led to an anthropocentric (human-centered) worldview, where human needs and human desires were placed above the health of ecosystems and non-human creatures.Thankfully, we are evolving.Ecospirituality has gained significant attention and popularity in the modern world due to a convergence of ecological, spiritual, political, and social challenges. It refers to a spiritual perspective that recognizes the interconnectedness of all life and emphasizes the sacredness of the natural world. It involves an awareness of the Earth's ecosystems, the understanding that human beings are part of a larger web of life, and the recognition that spiritual growth is inherently tied to the health and well-being of the planet.Ecospirituality often incorporates elements from various spiritual traditions, including indigenous wisdom, pantheism, animism, Buddhism, and environmental ethics. It seeks to address the environmental crises through spiritual practices, such as reverence for nature, rewilding, meditation, forest bathing, and radical kinship with all sentient beings.This rising interest reflects a growing recognition that environmental issues cannot be addressed solely through scientific or political means, but also require a profound shift in our worldview, values, and spirituality.So, where do you start? How can you change your relationship with the natural world as an integral part of your faith journey?Dr. Rachel Wheeler invites us to see ourselves and the world around us in radically new, yet ancient ways. Drawing from the deep wisdom of the Desert Mothers and Fathers, Dr. Wheeler reminds us that we humans aren't separate and distinct from creation, but in fact we are mutually dependent. While still emphasizing our human responsibility to steward the Earth and its resources, Dr. Wheeler sees human beings not as masters but caretakers and co-creators with nature. Her book, Radical Kinship: A Christian Ecospirituality, is available now!Bio:Professor Rachel Wheeler teaches courses on the Bible, Christian spirituality, ecospirituality, and spiritual practices at the University of Portland. She earned a PhD in Christian Spirituality from the Graduate Theological Union Berkeley and her other degrees reflect interests in monastic studies, literature, and music. She is particularly interested in the so-called desert Christians who lived in Egyptian, Palestinian, and Syrian deserts during late antiquity and her first book, Desert Daughters, Desert Sons: Rethinking the Christian Desert Tradition, offers a feminist critique of these Christians' practices. She is also interested in how people interpret their pro-environmental behavior as spiritual. An enthusiastic knitter and cyclist, she enjoys very much living in Portland, Oregon, with her spouse and two cats.Please follow us on social media (use the buttons below) and help us get the word out! (Also, please don't hesitate to use any of these channels or email to contact us with any questions, concerns, or feedback.)If you enjoyed this episode, please leave us a rating and a review, or share on your socials

Send us a textShort Summary: A deep dive into the enigmatic world of sleep, exploring its biological functions, evolutionary origins, and diverse manifestations across different species.About the Guest: Nicola Segata, PhD is a professor at the University of Trento in Italy.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and on YouTube. Partial versions are available elsewhere.Episode Summary: Dr. Segata explains metagenomics, the study of genetic material from multiple species, and how it has revolutionized microbiome research; microbiome transmission from mother to child; stability and plasticity of the microbiome throughout life stages; obesity and cancer; influence of diet, lifestyle, and medications like antibiotics on microbiome composition.Key Takeaways:Microbiome Variability: The human microbiome varies significantly between individuals and is influenced by genetics, environment, diet, and lifestyle. Thus, personalized approaches to microbiome health may be necessary.Transmission and Acquisition: Microbes are transmitted vertically from mother to child at birth and horizontally through personal interactions. This transmission can influence health outcomes over one's lifetime.Impact of Diet and Drugs: Diet, particularly coffee consumption, can significantly shape the microbiome, with some bacteria growing in response to specific dietary components. Medications like antibiotics and proton pump inhibitors can also markedly alter microbial communities.Health Implications: The microbiome is linked to various health conditions, from metabolic diseases to cancer, with some treatments like fecal microbiota transplantation showing promise in altering microbiome composition for health benefits.Ancient vs. Modern Microbiomes: Studies on ancient microbiomes, like the Iceman's, suggest that modern urban microbiomes differ from those of our ancestors, potentially impacting modern health issues.Related episodes:M&M #178: Microbiome & Gut-Immune Interactions in Obesity & Metabolic Health | June RSupport the showAll episodes (audio & video), show notes, transcripts, and more at the M&M Substack Affiliates: MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. Learn all the ways you can support my efforts

Subscriber-only episodeSend us a textShort Summary: A deep dive into the enigmatic world of sleep, exploring its biological functions, evolutionary origins, and diverse manifestations across different species.About the Guest: Nicola Segata, PhD is a professor at the University of Trento in Italy.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and on YouTube. Partial versions are available elsewhere.Episode Summary: Dr. Segata explains metagenomics, the study of genetic material from multiple species, and how it has revolutionized microbiome research; microbiome transmission from mother to child; stability and plasticity of the microbiome throughout life stages; obesity and cancer; influence of diet, lifestyle, and medications like antibiotics on microbiome composition.Key Takeaways:Microbiome Variability: The human microbiome varies significantly between individuals and is influenced by genetics, environment, diet, and lifestyle. Thus, personalized approaches to microbiome health may be necessary.Transmission and Acquisition: Microbes are transmitted vertically from mother to child at birth and horizontally through personal interactions. This transmission can influence health outcomes over one's lifetime.Impact of Diet and Drugs: Diet, particularly coffee consumption, can significantly shape the microbiome, with some bacteria growing in response to specific dietary components. Medications like antibiotics and proton pump inhibitors can also markedly alter microbial communities.Health Implications: The microbiome is linked to various health conditions, from metabolic diseases to cancer, with some treatments like fecal microbiota transplantation showing promise in altering microbiome composition for health benefits.Ancient vs. Modern Microbiomes: Studies on ancient microbiomes, like the Iceman's, suggest that modern urban microbiomes differ from those of our ancestors, potentially impacting modern health issues.Related episodes:M&M #178: Microbiome & Gut-Immune Interactions in Obesity & Metabolic Health | June Round*Not medAll episodes (audio & video), show notes, transcripts, and more at the M&M Substack Affiliates: MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. Learn all the ways you can support my efforts

Episode Summary Dr. SaraLou is a Women's life coach, GP, yogi, specialising in coaching professional women with overwhelm, burnout and stress, so that they can regain control, feel like them and live with joy and presence. Who's your ideal client and what's the biggest challenge they face? What are the common mistakes people make when trying to solve that problem? What is one valuable free action that our audience can implement that will help with that issue? What is one valuable free resource that you can direct people to that will help with that issue? What's the one question I should have asked you that would be of great value to our audience? When was the last time you experienced Goosebumps with your family and why? 1 to 1 Coaching with Dr. SaraLou Get in touch with Dr. SaraLou: Website, Instagram Learn more about how Uwe helps in-demand professionals and their VIPs to enjoy Unshakeable Two-getherness in their relationship (plus more free time and zero guilt). Or when you feel you'd be interested in working together you can Book A Chat With Uwe

Shortly after publication, a transcript of this episode will be published on SpecialEd.fm. Host: Dana Jonson Guest: Dr. Rebecca Jackson Chief Programs Officer, Brain Balance, Board-Certified Cognitive Specialist, and Doctor of Chiropractic. Guest Bio: Dr. Rebecca Jackson is a brain health expert and the Chief Programs Officer at Brain Balance. She is also a Board-Certified Cognitive Specialist and a Doctor of Chiropractic with over 15 years of dedicated research and hands-on application in cognitive development. She has passionately worked to improve the well-being of children and adults, authoring the book Back on Track to offer practical guidance on helping individuals of all ages thrive. Introduction: In this episode, Dana Jonson speaks with Dr. Rebecca Jackson, an expert in brain health and cognitive development. They explore the Brain Balance program, the neuroscience behind developmental challenges, and Dr. Jackson's new book Back on Track. The conversation covers brain development, attention issues, and strategies for strengthening cognitive function in children and adults. Episode Summary: Dr. Rebecca Jackson shares her professional journey from chiropractic care to becoming a leader in brain health. She introduces Brain Balance, a program designed to improve brain function and development through physical and cognitive activities. Dr. Jackson and Dana discuss the importance of addressing the root causes of cognitive and behavioral challenges rather than just focusing on the symptoms. They also touch on the impacts of the COVID-19 pandemic on children's brain development and mental health. Dr. Jackson explains the concepts from her book Back on Track, offering practical advice for parents and educators to help children overcome developmental challenges. Key Discussion Points: Dr. Jackson's professional journey and her involvement in brain health and cognitive development. The Brain Balance program: strengthening and improving the brain for both children and adults without focusing solely on diagnoses. How foundational development affects executive functions, attention, emotional regulation, and behavior. The impact of the COVID-19 pandemic on children's mental health and cognitive development. The importance of addressing root causes of cognitive challenges rather than simply treating symptoms. Dr. Jackson's book Back on Track, and how it provides strategies for parents to optimize their child's brain health and development. Practical advice for improving attention, executive function, and emotional regulation in children. Guest's Insights and Advice: Attention and development: Attention struggles in children and adults can be related to gaps in foundational brain development. Strengthening brain function can help address these issues. Practical solutions: Improving brain health can be achieved through simple, daily activities involving movement, sensory stimulation, and proper nutrition. Parent involvement: Parents need to be proactive in identifying potential cognitive challenges in their children and understand that behavior may reflect underlying brain development issues. Consistency: It's important to incorporate healthy brain habits consistently for long-term benefits. Resources Mentioned: Back on Track by Dr. Rebecca Jackson — Practical guidance for improving brain health and development. Brain Balance Program — A comprehensive program designed to strengthen brain connectivity in both children and adults. Visit Brain Balance for more information. Call to Action: After listening to this episode, consider reflecting on your child's development and behavior. Identify areas where they may be struggling and explore options like Brain Balance to strengthen their cognitive abilities. For more detailed strategies, pick up a copy of Dr. Jackson's book Back on Track. Engagement and Sharing: Share the Episode with a Friend: If you found this episode helpful, share it with other parents or educators who could benefit from learning about brain health and cognitive development. Leave a Review: If you enjoyed the show, please leave a review on your favorite podcast platform to help support Special Ed on Special Ed. Follow Dr. Rebecca Jackson on Social Media: Facebook: @DrRebeccaJacksonLinkedIn: Dr. Rebecca Jackson Follow Dana Jonson on Social Media: Twitter: @SpecialEdCast If you like this episode, be sure to check out: Neurodiversity Unveiled: Beyond the Should Storm of Parenting with Dr. Alison Escalante Memorable Quote: "A tired brain is going to have a harder time paying attention. We must strengthen and support brain health from the ground up to help children thrive." — Dr. Rebecca Jackson Disclaimer: The content of this podcast is for informational purposes only and is not intended as a substitute for professional advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.

Dr. Melissa Burt is an esteemed Associate Professor in the Department of Atmospheric Science at Colorado State University, where her research specializes in Arctic clouds, radiation, sea ice, and climate change. In addition to her role as a professor, Dr. Burt serves as the Associate Dean for Diversity and Inclusion in the Walter Scott, Jr. College of Engineering at the same institution. She is also an active mother and a dedicated member of Science Moms, a nonpartisan group of climate scientists who are also mothers, committed to educating and empowering moms across the nation to advocate for climate solutions. Dr. Burt lives in Colorado with her husband and young daughter.Episode Summary:Dr. Melissa Burt, an expert in atmospheric science, discuss the pressing issue of climate change and its impact on our planet. The conversation delves deep into how human-caused climate change is exacerbating extreme heat events, the importance of clean energy, and what each of us can do to mitigate the effects of pollution for future generations.The discussion underscores how the warming of our planet, driven mainly by human activities such as burning fossil fuels, is leading to more frequent and intense extreme weather events. Key strategies to combat climate change include reducing carbon emissions by transitioning to electric transportation and energy-efficient appliances, using renewable energy sources, and advocating for policy changes at local, state, and national levels. Dr. Burt emphasizes that individual actions, although crucial, must be part of a broader collective effort to significantly impact climate change and protect our children's future.Key Takeaways:Human-Caused Climate Change: The burning of fossil fuels contributes significantly to the thickening heat-trapping blanket around our Earth, leading to more severe weather events, such as heatwaves, wildfires, and hurricanes.Individual and Collective Action: Simple changes like switching to energy-efficient appliances and electric vehicles, combined with advocating for larger systemic changes, can collectively make a significant impact.Impact on Children and Vulnerable Populations: Climate change disproportionately affects children and the elderly, and proactive measures are needed to safeguard these vulnerable groups.Hope for the Future: Despite the challenges, there is great potential for reversing damage if aggressive and concerted actions are taken swiftly and efficiently.Support The Sponsors who Support the Transform Your Mind podcast!RO.CO The Ro Body Program provides access to the most popular weight loss shots on the market. Go to RO.CO/TRANSFORMShopify - Go to shopify.com/transform now to upgrade your businessSee this video on The Transform Your Mind YouTube Channel https://www.youtube.com/@MyhelpsUs/videosTo see a transcripts of this audio as well as links to all the advertisers on the show page https://myhelps.us/Follow Transform Your Mind on Instagram https://www.instagram.com/myrnamyoung/Follow Transform Your mind on Facebookhttps://www.facebook.com/profile.php?id=100063738390977Please leave a rating and review on iTunes https://podcasts.apple.com/us/podcast/transform-your-mind/id1144973094

“An apology is a small word, but has enormous power interpersonally.” Episode Summary: Dr. Amy Edmondson, the world's leading authority in psychological safety, discusses her background and the science of failing well. She shares her journey from growing up in New York City to becoming a professor at Harvard Business School. She explains how her mentor, Buckminster Fuller, influenced her curiosity and joy for learning. Dr. Edmondson also delves into the concept of psychological safety and its impact on team learning and innovation. She distinguishes between mistakes and failures and introduces the three failure archetypes: intelligent failures, basic failures, and complex failures. Finally, she explores the relationship between uncertainty and preventability in the context of failure. In this conversation, Amy Edmondson and Shannon Cassidy discuss the importance of failing well and how to respond to failure. They explore the concept of psychological safety and its role in creating a culture that embraces failure as a learning opportunity. They also discuss the criteria for intelligent failure and share stories of successful individuals who have learned from their failures. The conversation covers topics such as self-awareness, the power of questions, the role of apology in healing relationships, and how to thrive as fallible human beings. R.O.G. Takeaway Tips: The relationship between uncertainty and preventability in the context of failure Failing well requires creating a culture of psychological safety where individuals feel comfortable taking risks and learning from failure. Self-awareness is crucial in failing well, as it allows individuals to recognize their weaknesses and make necessary adjustments. Asking good questions is a powerful tool in responding to failure, as it encourages reflection and learning. Apologies have the power to heal relationships and should be genuine, taking accountability and offering to make amends. To thrive as fallible human beings, it is important to persist through struggles, be reflective, and take more risks. Fallible Human Beings (FHB) coined by Maxi Maltzby Persist through struggles Invest time in reflection Learn how to apologize. Fail more often (take more smart risks). Guest Bio: Amy Edmondson is the Novartis Professor of Leadership and Management at the Harvard Business School, a chair established to support the study of human interactions that lead to the creation of successful enterprises that contribute to the betterment of society. She lives in Cambridge, Massachusetts, and is the author of Right Kind of Wrong. After decades of award-winning research, Amy Edmondson is here to upend our understanding of failure and make it work for us. In Right Kind of Wrong, Edmondson provides the framework to think, discuss, and practice failure wisely. Outlining the three archetypes of failure—basic, complex, and intelligent—Amy showcases how to minimize unproductive failure while maximizing what we gain from flubs of all stripes. She illustrates how we and our organizations can embrace our human fallibility, learn exactly when failure is our friend, and prevent most of it when it is not. This is the key to pursuing smart risks and preventing avoidable harm. With vivid, real-life stories from business, pop culture, history, and more, Edmondson gives us specifically tailored practices, skills, and mindsets to help us replace shame and blame with curiosity, vulnerability, and personal growth. You'll never look at failure the same way again. Resources: Amy Edmondson Harvard Professor  The Right Kind of Wrong: The Science of Failing Well by Amy Edmondson   The Fearless Organization by Amy Edmondson   Amy Edmondson Wikipedia Where to find R.O.G. Podcast: R.O.G on YouTube R.O.G on Apple Podcasts R.O.G on Spotify How diverse is your network?  N.D.I. Network Diversity Index What is your Generosity Style?  Generosity Quiz Credits: Amy Edmondson, Sheep Jam Productions, Host Shannon Cassidy, Bridge Between, Inc. Coming Next: Please join us next week, Episode 193, with special guest Mike Atkinson.

Episode Summary:Dr. Scott Schmidt joins the podcast to share his knowledge about caring for those with serious illness and those who are in the dying process. As a medical doctor with an expansive background in Emergency Medicine, Hospice Care, and now as a leader in the Primary Palliative Care field, Scott invites us to consider how we go about the realities that surround end-of-life. Along the way, we get a solid sense of what kind of attitudes, questions, and conversations are needed from both sides of the medical encounter. But don't be fooled, this episode has teachings for the healthy as much as for those with serious health challenges. In considering the inevitable fate of all bodies, Dr. Schmidt shows us how we can be more prepared and receptive to our individual impermanence at any point in our lives. Indeed, we come to see how forethought can help us be present and feel less overwhelmed in more trying times.Further on in the podcast, we learn how Scott's encounters with live-saving measures and his natural inclination toward helping those facing illness and death pushed him forward to being a leader in the Primary Palliative Care approach. Towards the end of the show, we get a very real glimpse into the difficulty of modern medicine, with its messy and often morally distressing dilemmas.With depth and humility in the face of the unknowable, this conversation is a remarkable one for both the significances that occur in the latter stages of life, and also with the genuine soulfulness Dr. Schmidt brings to these moving encounters. As he says, navigating serious illness and the inevitability of death is no simple thing. About Dr. Scott Schmidt: Scott Schmidt is an Emergency Medicine doctor and cultural change leader who is charged with developing Primary Palliative Care competencies. About Primary Palliative Care: is a subspecialty of medicine, that seeks to plan and address serious illness situations with an orientation to minimize suffering while tending to the whole person. Considered an upstream evolution from Palliative Care, Primary Palliative Care seeks to support Palliative Care competencies in all providers and teams.

Dr. Nicole F. Roberts holds a doctorate in public health and a master's in public policy. She is a distinguished game-changer in health, human rights, and generosity and the author of Generosity Wins: How and Why This Game-Changing Superpower Drives Your Success. Dr. Roberts is the founder of Health and Human Rights Strategies, a Washington, DC-based advisory firm, and the Executive Director of Feed A Billion, an international nonprofit aimed at feeding girls in need. Additionally, she hosts the Global Good podcast and is a contributor to Forbes, bringing her profound insights from working with influential individuals such as presidents, diplomats, professional athletes, and billionaires.Episode Summary:Dr. Roberts explains the neuroscience behind generosity, revealing how acts of kindness activate reward centers in the brain, enhancing our health and emotional state. Myrna and Dr. Roberts dissect various narratives, including the transformational power of gratitude in corporate settings and how philanthropy boosts business growth. They also touch upon the unique experiences of humans, the only species inherently generous, and how purposeful giving can alter one's professional and personal life for the better. Dr. Roberts emphasizes intentionality in generosity, demonstrating how even small acts can lead to substantial ripple effects.Support our Sponsors who Support the Transform Your Mind podcast!Shopify - This Year take your business to the next level with a Shopify online store. Sign up for a one-dollar-per-month trial period at SHOPIFY.COM/transformClaritin - If you are Ready to live life as if you don't have allergies? Go to CLARITIN.COM right now for a discount. BetterHelp - Give online therapy a try at betterhelp.com/ TYM and get on your way to being your best self.”GoFundMe - The next time you need help head over to GoFundme.com/transform Start your fundraiser today. Asking for help is the smart thing to do. The Bossbabe Podcast, a show for entrepreneurs looking to start, grow, or scale a freedom-based business. www.bossbabe.com See this video on The Transform Your Mind YouTube Channel https://www.youtube.com/@MyhelpsUs/videosTo see a transcripts of this audio as well as links to all the advertisers on the show page https://myhelps.us/Follow Transform Your Mind on Instagram https://www.instagram.com/myrnamyoung/Follow Transform Your mind on Facebookhttps://www.facebook.com/profile.php?id=100063738390977Please leave a rating and review on iTunes https://podcasts.apple.com/us/podcast/transform-your-mind/id1144973094

Welcome to our latest podcast episode, where we dive into a revolutionary platform transforming the way we create and consume educational content. Join us as we introduce Savant, a game-changer for businesses, entrepreneurs, and boss mothers alike. In this episode, Dr. Dorine shares her journey from author to innovator, detailing the inspiration behind Savant. Discover how this platform streamlines the process of turning written content into captivating videos, eliminating the need for multiple professionals and saving both time and money. Learn how Savant empowers authors to maximize their content's value, turning books into lucrative online courses with ease. Explore how entrepreneurs can leverage Savant to create engaging training materials and promotional videos, enhancing their online presence and boosting revenue potential. Tune in as we uncover the benefits of edutainment and how Savant is revolutionizing the way we learn and retain information. Don't miss out on this enlightening conversation that could reshape your approach to content creation and education.  Episode Summary: Dr. Dorine discusses her journey from writing a book to creating an innovative platform called Savant, which transforms written content into engaging videos. She emphasizes the challenges of traditional methods of creating online courses, involving multiple specialists and high costs. Savant simplifies the process by automatically generating visuals and voiceovers from uploaded text, offering various customization options. Dr. Dorine highlights the time and cost efficiency of Savant compared to traditional approaches, making it accessible for authors, educators, business professionals, and more. She stresses the importance of visual and engaging content for effective learning, citing the platform's potential to revolutionize  Remember to share and subscribe to my Podcast "Empower with Nancy" and share with your friends and colleagues who might also benefit from this episode. Thank you for your support!" With Gratitude, Nancy Learn more about Nancy Davidson through the following links: ⁠⁠⁠⁠⁠⁠Website⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠Facebook⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠Instagram⁠⁠⁠ Tiktok #savantz.ai #edutainment #innovation #AI #empowermentpathways #empowerwithnancy #education #entertaining

Dr. Christopher Macklin is a multifaceted individual who brings together holistic health and spirituality through his comprehensive background. With a Ph.D. earned from his thesis work, Dr. Macklin specializes in treating a spectrum of emotional disorders including addictions, chronic depression, schizophrenia, and bipolar disorders. As a medical intuitive with the capability to see and interact with angelic beings and energy frequencies, he has developed unique healing protocols that address viruses, Lyme disease, HIV/AIDS, and other challenging illnesses. Episode Summary:Dr. Christopher Macklin to delves into the profound topics of mental health crisis and its impact on collective consciousness. Myrna highlights the essence of collective consciousness and queries Dr. Macklin about his journey as a medical intuitive and his view on crystalline entities' attachments caused by low vibrational states.The conversation courses through the effects of collective consciousness on individual well-being, emphasizing the importance of gratitude, personal vibration, and the power of prayer. Dr. Macklin shares his perspectives on shielding oneself from negative energies and entities, with practical advice on maintaining high-frequency states for overall wellness.Key Learnings:Understanding the role of collective consciousness and its influence on individual mental states.Gratitude as a transformative tool for elevating personal vibration.The concept of vibrational alignment to protect from lower dimensional entity attachments.The benefits of meditation and spiritual practices in enhancing one's life and contributing positively to the collective consciousness.Dr. Macklin's insights on the nature of conditions like schizophrenia as being connected to one's ability to interact with different dimensional beings.Ready to improve your health or business? Look no further than our amazing sponsors! Support them and support Transform Your Mind podcast!Shopify - This Year take your business to the next level with a Shopify online store. Whether you are Selling a little or a lot Shopify helps you do your thing, however you cha-ching.Sign up for a one-dollar-per-month trial period at SHOPIFY.COM/transformClaritin - Shoutout to Claritin for supporting this episode and providing us with samples.If you are Ready to live life as if you don't have allergies? It's time to Live Claritin Clear.Go to CLARITIN.COM right now for a discount so you can Live Claritin Clear.Clairol - As someone who has textured and curly hair, I'm excited to share Clairol Textures & Tones came out with a permanent color specifically for curly, hair types! Say hello to the improved formula and new look while preserving curls and shine!”See this video on The Transform Your Mind YouTube Channel https://www.youtube.com/@MyhelpsUs/videosTo see a transcripts of this audio as well as links to all the advertisers on the show page https://blog.myhelps.us/Follow Transform Your Mind on Instagram https://www.instagram.com/myrnamyoung/Follow Transform Your mind on Facebookhttps://www.facebook.com/profile.php?id=100063738390977Please leave a rating and review on iTunes https://podcasts.apple.com/us/podcast/transform-your-mind/id1144973094

A deep dive into the transformative world of Artificial Intelligence (AI) with the renowned expert, Dr. Joerg Storm. With over two decades of experience in AI and digital transformation, Dr. Storm brings unparalleled insights from the frontline of AI's integration into business and leadership.connect with Dr. Jörg Storm over Linkedin: https://www.linkedin.com/in/joergstormsubscribe to Dr. Jörg Storm's newsletter "Digital Storm" here: https://drstorm.substack.com/subscribeWhy You Can't Miss This Episode:Demystifying AI for Strategic Advantage: Learn how AI can transcend beyond the buzzword to become a core component of strategic decision-making in businesses.Data Mastery for AI Success: Discover the critical importance of data quality, organization, and analysis as the foundation of successful AI implementation.Leadership in the Age of AI: Uncover how senior leaders, including CEOs and CIOs, must evolve to harness the full potential of AI technologies.Episode Summary: Dr. Joerg Storm, the Global Head of AI key infrastructure at a leading German automobile manufacturer, shares his wisdom on the future of AI, emphasizing the need to start small, think big, and use AI to augment human capabilities, not replace them. The conversation spans from the practical steps for integrating AI into businesses, the emerging trends like blockchain and quantum computing, to the challenges and ethical considerations leaders must navigate. Dr. Storm's insights are not only profound but also actionable, making this episode a must-listen for anyone looking to leverage AI for business transformation and leadership excellence.Follow and Subscribe for More Insights: Dive deeper into the world of customer experience, transformation, and leadership with the CX Goalkeeper Podcast. Your journey towards a deeper understanding of AI and its implications for the future of business starts here. Don't miss out on invaluable insights that can shape your strategies and leadership. Follow us, subscribe, and share your feedback to help us deliver the content you need:Podcast Page: CX Goalkeeper PodcastApple Podcast: Subscribe on Apple PodcastSpotify: Subscribe on SpotifyGoogle Podcast: Subscribe on Google PodcastAbout me: Learn more about GregWe are not just in a B2B or B2C business; we are in a human-to-human environment. Engage with us, share your thoughts, and let's grow together. Your feedback is invaluable as we continue to explore the depths of customer experience and leadership in the digital age. Subscribe and become a part of our growing community of professionals who are shaping the future, one episode at a time.

Episode Summary: Dr. Michelle Bengtson joins David Robison of LifeToday to explore the challenging journey of maintaining faith during periods of waiting for healing. Drawing from her personal struggles and professional insights as a neuropsychologist, Dr. Bengtson shares about the emotional, physical, and spiritual pain that tests our faith. Through her new book, "The Hem of His Garment," she offers hope, encouragement, and practical advice to those navigating the complexities of pain and waiting. Join us as we discuss the importance of pressing into faith, the biblical examples of those who waited on God's timing, and how we can find strength and hope in the midst of suffering. This is a replay of a LifeToday interview. Quotables from the Episode: "In our pain, we have a choice. We can either retreat from God and blame Him, or we can lean in and continue to enact our faith, waiting for His healing in His perfect time and way."  "God never withholds anything good from His children. If my physical healing today was in my best interest, I know He would do it."  "Walking by faith sometimes comes by crawling by faith."  "Getting out of bed or just breathing, sometimes, that is victory." "God can handle our honesty. It's our flesh speaking, but it's honest and it's real."  "The pain of childbirth is so great... But when you get the joy that comes out of it, it makes it all worthwhile."  Scripture References: The story of the woman with the issue of blood who touched the hem of Jesus' garment and was healed, illustrating the journey of faith and waiting for healing. [No specific verse cited, but the story is found in Mark 5:25-34, Luke 8:43-48, and Matthew 9:20-22.]   Recommended Resources:  Sacred Scars: Resting in God's Promise That Your Past Is Not Wasted by Dr. Michelle Bengtson  The Hem of His Garment: Reaching Out to God When Pain Overwhelms by Dr. Michelle Bengtson YouVersion 5-Day Devotional Reaching Out To God When Pain Overwhelms   Today is Going to be a Good Day: 90 Promises to Start Your Day Off Right by Dr. Michelle Bengtson, winner of the AWSA 2023 Inspirational Gift Book of the Year Award, the Christian Literary Awards Reader's Choice Award in four categories, and the Christian Literary Awards Henri Award for Devotionals YouVersion 7-Day Devotional, Today is Going to be a Good Day YouVersion 7-Day Devotional, Today is Going to be Another Good Day Breaking Anxiety's Grip: How to Reclaim the Peace God Promises by Dr. Michelle Bengtson Breaking Anxiety's Grip Free Study Guide Free 7-Day YouVersion Bible Reading Plan for Breaking Anxiety's Grip Hope Prevails: Insights from a Doctor's Personal Journey Through Depression by Dr. Michelle Bengtson, winner of the Christian Literary Award Reader's Choice Award Hope Prevails Bible Study by Dr. Michelle Bengtson, winner of the Christian Literary Award Reader's Choice Award Trusting God Through Cancer 1 Trusting God Through Cancer 2 Revive & Thrive Women's Conference Subdue Stress and Anxiety: Fifteen Experts Offer Comprehensive Tools in Ten Minutes a Day. Use my link plus discount code BENG99 to save $90 on course (course will be $99.) Free Download: How To Fight Fearful/Anxious Thoughts and Win   Social Media Links for Guest and Host: Connect with David Robison of LifeToday: Website / Facebook / Instagram For more hope, stay connected with Dr. Bengtson at: Order Book Breaking Anxiety's Grip / Order Book Hope Prevails  /  Website  /  Blog  /  Facebook / Twitter (@DrMBengtson)  /  LinkedIn  /  Instagram / Pinterest / YouTube   Hosted By: Dr. Michelle Bengtson Audio Technical Support: Bryce Bengtson

EPISODE SUMMARY: Dr. Pearson talks about how you just don't know the back story of the person yelling or screaming in front of you. Listen to examples of why so many folks seem angrier than the situation might call for and what you can do to improve your life and theirs. ON THIS EPISODE, WE DISCUSS… A lot of things have been happening and going on around the office that has made Dr. Pearson realise she would like to talk about other people. Everywhere you are you may run into someone who seems a lot more angrier than what the situation might call for. We are living in stressful times, but finding out the back story might help us to respond better. Sometimes you do need to give people a little bit of time to calm down. Dr. Pearson tells us some stories to give examples of how knowing the why or background stories help us to understand why the person may be acting out of character. Get creative with what someone's back story might be so that you can handle the situation with more grace. CALLS-TO-ACTION: Get a copy of the book on Amazon. If you got some questions, reach out through the website: www.8minutestoageless.com www.8minutestoageless.org Who is Dr. Kelli Pearson? Experienced Chiropractor since 1982, working in collaborative health care settings. Currently a co-owner of a multi-disciplinary clinic, including chiropractors, massage therapists, movement specialists, and nutritional coaches. Owner of Real Work Life, a corporate wellbeing consulting company, and author of "8 Minutes to Ageless," teaching a minimalistic approach to ageing well. Graduate of UCLA with a BS in Kinesiology and a Doctorate from Palmer West Chiropractic College. Socials: www.linkedin.com/in/kelli-pearson-0695035/

About The Guest(s): Dr. Shitel Patel is a double board-certified plastic surgeon and the owner and founder of Lift Plastic Surgery in Houston. He is also the owner and founder of Advital, a business intelligence CRM for aesthetic medicine and a medical lead management system. Episode: Summary: Dr. Shitel Patel discusses the importance of embracing AI and technology in the aesthetic medicine industry. He shares his journey as a plastic surgeon and the challenges he faced in building his practice. Dr. Patel explains how Advital, his software company, helps practices improve their marketing, communication, and patient journey. He emphasizes the need for accountability and process in running a successful practice and highlights the power of AI in lead management and conversion. Dr. Patel also discusses the future of AI in the industry and the importance of continuous improvement and adaptation. Key Takeaways: - Embrace AI and technology to improve marketing, communication, and patient journey. - Accountability and process are essential for running a successful practice. - AI can help manage leads, improve response times, and automate follow-ups. - The fortune is in the follow-up; consistent and meaningful communication with patients is   crucial. - The successful practice has a well-defined process for consultations, pre- and post-operative care. If you are ready to create change and want to learn more about APX, please visit www.apxplatform.com to schedule a discovery call. Please visit our youtube channel at: www.youtube.com/channel/UCxOkt_vcZd4lXKwcGbgMYaQ If you found this episode valuable, please share this with a friend or colleague that would benefit from listening.

EPISODE SUMMARY: Dr. Pearson talks about some exciting new technology using light that is opening doors for recovery on so many levels. Moreover, this treatment has no downside. Imagine that! She reminds us the move to health is adding what we need as well as getting rid of what poisons us. ON THIS EPISODE, WE DISCUSS… Joint mobility helps with nerve function. Problems in your neck or shoulder area can cause a lot of time pain in your hands. Any disease begins at a cellular level.  You are only as healthy as your cells are healthy. Dr. Pearson talks about lasers and why it can actually help and be good for you. Lasers will not heal you by yourself, you still have to do some work, but it is a great start. Go to https://www.erchonia.com to find providers in your area and more information. CALLS-TO-ACTION: Get a copy of the book on Amazon. If you got some questions, reach out through the website: www.8minutestoageless.com www.8minutestoageless.org Who is Dr. Kelli Pearson? Experienced Chiropractor since 1982, working in collaborative health care settings. Currently a co-owner of a multi-disciplinary clinic, including chiropractors, massage therapists, movement specialists, and nutritional coaches. Owner of Real Work Life, a corporate wellbeing consulting company, and author of "8 Minutes to Ageless," teaching a minimalistic approach to ageing well. Graduate of UCLA with a BS in Kinesiology and a Doctorate from Palmer West Chiropractic College. Socials: www.linkedin.com/in/kelli-pearson-0695035/

EPISODE SUMMARY: Dr. Pearson talks about how to stand your ground physically in order to be present and to hear the truth. So much time is wasted in life not hearing the truth or telling the truth, so let your body be in good form to make this easier. Secondly, she talks about the maintenance of the most important joint in our body, the hips. ON THIS EPISODE, WE DISCUSS… Standing up for yourself or speaking up for yourself. Telling your truth. If you are not grounded it will be very hard to be present in knowing the truth. You will also not be willing to be open or move forward. Practice this week in being grounded in your body. Moving to your important hip joints. If you can not squat down then that is not good. Do what you can to pull your knee to your chest for a minute. Stand against a wall and pull your knee to your chest or lay on your back with a pillow if needed and try it that way if you must. Dr. Pearson gives several different ways you can do it if you have different difficulties.  A little resistance is good. Do not wait too long as it could turn into a bigger problem. The last thing to talk about is the importance of always learning. It would be great to try to learn something new every day.  Think about it…what is the one big thing that you want to learn about? CALLS-TO-ACTION: Get a copy of the book on Amazon. If you have some questions, reach out through the website: www.8minutestoageless.com www.8minutestoageless.org Who is Dr. Kelli Pearson? Experienced Chiropractor since 1982, working in collaborative health care settings. Currently a co-owner of a multi-disciplinary clinic, including chiropractors, massage therapists, movement specialists, and nutritional coaches. Owner of Real Work Life, a corporate wellbeing consulting company, and author of "8 Minutes to Ageless," teaching a minimalistic approach to ageing well. Graduate of UCLA with a BS in Kinesiology and a Doctorate from Palmer West Chiropractic College. Socials: www.linkedin.com/in/kelli-pearson-0695035/

About The Guests: - Dr. Morris Hartstein is an ophthalmologist and oculoplastic surgeon, and the founder of Operation Ethiopia, an NGO that provides eye care services in Ethiopia. He has been traveling to Ethiopia since 2014, helping build an extensive program in Gondar and Addis Ababa. - Dr. Seblewongel Eshetu is an oculoplastic surgeon from Ethiopia. She completed her fellowship in oculoplastics with Dr. Hartstein in Israel as part of Operation Ethiopia's Physician Training Program. Dr. Eshetu is currently working at St. Paul's Hospital in Addis Ababa, where she is the first female oculoplastic surgeon in the country. Episode Summary: Dr. Cat Burkat interviews Dr. Morris Hartstein who shares his journey of getting involved in global ophthalmology and oculoplastics in Ethiopia. He initially visited Ethiopia with his family on a volunteer trip and was inspired by the level of need and poverty he witnessed. Since then, he has been traveling to Ethiopia multiple times a year, providing eye care services, training residents and fellows, and organizing cataract surgery campaigns. Dr. Hartstein emphasizes the importance of building relationships, understanding the local culture, and going through proper government and medical channels to ensure the success and sustainability of global outreach programs. At the conclusion of the episode, Dr. Cat Burkat interviews Dr. Seblewongel Eshetu, who shares her experience training in oculoplastics with Dr. Hartstein, which included training both in Israel and Ethiopia. She also describes the challenges she faces as an oculoplastic surgeon in Ethiopia and the importance of sharing surgical skills and knowledge between visiting surgical groups and local physicians. Dr. Eshetu emphasizes the need for advanced materials and instruments to treat patients in Ethiopia, where many cases present in advanced stages. She also highlights the impact of oculoplastic surgery on both patients and their families, as many travel from rural areas and face significant disruptions to their lives. Both Dr. Hartstein and Eshetu conclude by expressing their commitment to teaching and expanding oculoplastic surgery in Ethiopia. Key Takeaways: 1. Global surgical trips should always respect local culture, traditions, and other providers. 2. Sustainable education and training are the ideal as this allows for local surgeons to continue optimal patient care. 3. Working in global oculoplastics must be properly approached with the government health department, local hospitals, NGOs to provide safe and effective outcomes. 4. Training in oculoplastics in Israel provided Dr. Eshetu with a different perspective and advanced surgical knowledge. 5. The transition back to Ethiopia was challenging due to differences in lighting, instruments, and materials. 6. Sharing surgical skills and knowledge with visiting surgical groups is crucial for advancing oculoplastic surgery in Ethiopia. 7. Access to advanced materials and instruments is essential for treating patients in Ethiopia and similar countries, where many cases present in advanced stages. 8. Oculofacial plastic surgery can have a significant impact on patients, who can then move forward in their daily lives and provide for their families. If you're an ASOPRS Member, Surgeon or Trainee and are interesting in hosting a podcast episode, please submit your idea by visiting: https://asoprs.memberclicks.net/podcast#!/  

EPISODE SUMMARY: Dr. Pearson talks about how our culture of denial is so pervasive that it blinds us to knowing when to reach out for help. She shares a very interesting case study that typified how denial leads to disability.  ON THIS EPISODE, WE DISCUSS… Book reference: At Peace by Samuel Harrington MD. This podcast is not about death, but Dr. Pearson has always embraced the fact that she will die and believes all of us should do the same. Denial is a lie and the more you lie to yourself the more you will believe it. Marketing is a great tool of denial as it makes you believe something that might not be true. Remember it's important to find out what the cause of the pain is so going back to the beginning is what is going to help you the most not what it is currently. What is it that you are denying?  What is it that you are pretending to not be a problem when it is? Do not be afraid to ask around if you don't know what to do. Healing Local: https://spokane.healinglocal.org Be honest with yourself and allow others to be honest with themselves too. CALLS-TO-ACTION: Get a copy of the book on Amazon. If you got some questions, reach out through the website: www.8minutestoageless.com www.8minutestoageless.org Who is Dr. Kelli Pearson? Experienced Chiropractor since 1982, working in collaborative health care settings. Currently a co-owner of a multi-disciplinary clinic, including chiropractors, massage therapists, movement specialists, and nutritional coaches. Owner of Real Work Life, a corporate wellbeing consulting company, and author of "8 Minutes to Ageless," teaching a minimalistic approach to ageing well. Graduate of UCLA with a BS in Kinesiology and a Doctorate from Palmer West Chiropractic College. Socials: www.linkedin.com/in/kelli-pearson-0695035/

Episode Summary: Dr. Devorah Heitner, a seasoned authority on the intersection of family dynamics and technology, has dedicated extensive years of research to investigate the influence of screens on children. Her latest publication, titled "Growing Up in Public," offers a comprehensive exploration of both the positive and negative aspects of maturing in a digitally connected world. Back for her second apperance on the show (previously joining me on EP260), Devorah is here to discusses how, contrary to our previous notions, it appears that coming of age on the internet might not be as detrimental as we once believed.For those that are new around here, I release bonus episodes that serve a niche part of my audience so if this topic doesn't fit what you're looking for, join me back here next time for a conversation about decluttering that you don't want to miss! ------------------------------Links Discussed in This EpisodeOrder a Copy of Minimalist Moms: Living and Parenting with SimplicityWait Until 8th PledgePrevious Episode: EP260 Becoming ScreenwiseBook: Screenwise: Helping Kids Thrive (and Survive) in Their Digital WorldConnect with Devorah:Sign up for Devorah's free 7-day Tech Reset here.Book: Growing Up in Public: Coming of Age in a Digital AgeWebsite | Twitter | Instagram | SubstackShow Notes for Episode 296Enjoy this Podcast?Post a review and share it! If you enjoyed tuning into this podcast, then do not hesitate to write a review. You can also share this with your fellow mothers so that they can be inspired to think more and do with less. Order (or review) my recent book, Minimalist Moms: Living & Parenting With SimplicityQuestions? You can contact me through my website, find me on Instagram, or like The Minimalist Moms Page on Facebook.Thanks for listening! For more updates and episodes, visit the website. You may also tune in on Apple Podcasts, Spotify, Google Podcasts, or Stitcher.Checkout the Minimalist Moms Podcast storefront for recommendations from Diane.If you enjoyed today's episode of the Minimalist Moms Podcast, then hit subscribe and share it with your friends!Episode Sponsors |The Minimalist Moms Podcast would not be possible without the support of weekly sponsors. Choosing brands that I believe in is important to me. I only want to recommend brands that I believe may help you in your daily life. As always, never feel pressured into buying anything. Remember: if you don't need it, it's not a good deal!Our Sponsors:* Check out Armoire and use my code MINIMALIST for a great deal: http://www.armoire.style* Check out Ideal Living and use my code MINIMALIST for a great deal: https://airdoctorpro.com/* Check out Quince: https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=&cad=rja&uact=8&ved=2ahUKEwjVtJG56NKAAxU-N0QIHQf1Bq8QFnoECBwQAQ&url=https%3A%2F%2Fwww.quince.com%2F&usg=AOvVaw15ySPxxJ1v1l0I4qSPAJS5&opi=89978449* Check out Stride K12: K12.com/MINIMALISTSupport this podcast at — https://redcircle.com/minimalist-moms-podcast2093/exclusive-contentAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

Episode Summary:   Dr. Josie and leaders speak about deeper aspects of brain neurotransmitters and neuro-inflammation, and the science behind How & Why essential oils support and work in the brain.    Don't miss:   *How to anoint yourself with Melissa, Patchouli, Frankincense and Sandalwood  *Discover which oils are suggested for brain support *How oils work in our brain *Deeper information on Frankincense and other oils *Which oils support  serotonin and dopamine *And Arin's great Hack to share this fabulous info more easily  Grab the Protocols and Recipes: Visit  https://www.hellovisionary.life and be sure to subscribe to our email list... You will be sent an email with the video recording of this call and any important protocols and resources given out.   How to get your own doTERRA oils & supplements: If you would like to purchase one of the oils or wellness products we have mentioned, please speak with the person who invited you to the call so you can get them at the best price. We recommend that you start with your FREE doTERRA wholesale account. You can pick out any items you like, and if they add up to $150, you will receive a FREE diffuser. Please reach out to the person who shared this podcast with you for guidance or email one of us. If you do not have a connection to Doterra, please email arin@jasmineandjuniper.com. About the Hosts:  This podcast is a collaborative effort between doTERRA Presidential Diamond Aisha Harley, doTERRA Blue Diamond Dr. Josie Schmidt, doTERRA Blue Diamond Arin Fugate, and doTERRA Diamond Ariana Harley. They are the founders of the Visionary Leaders Collective. Connect with us: Aisha Harley- aishaharley.me FB- https://www.facebook.com/aisha.harley Ariana Harley - https://www.arianaharley.com/ Josie Schmidt- FB Personal Page: https://www.facebook.com/josie.h.schmidt Arin - https://msha.ke/jasmineandjuniper/   Contact Email: ariningraham@gmail.com   Welcome to the Visionary Leaders Podcast   Here you will gain the knowledge you need to bring essential oils, plant medicine and wisdom, supplementation, and functional medicine into your life.   We have a weekly show: “Learn to be the Healer in Your Home” where we hear stories from our community on how they integrated essential oils, supplementation, and functional medicine into their lives as a pathway to healing.   Once a month we publish a show called “Oils A-Z” with Ariana Harley, Louise Rose ND, Mica Carew ND, LAc, Will Wan L.Ac., MSOM, Dipl.O.M. (NCCAOM). Each month on Oils A-Z, Ariana and our wonderful Essential Wellness Practitioners take us on a deep-dive into the physical, mental, emotional, and spiritual benefits of different essential oils.   Learn more about our community at hellovisionary.life   Our website is https://www.hellovisionary.life. This is where all of our resources live. You can learn how to use essential oils in your home and how to share oils with your community through webinars, phone calls, and other resources.   Please take a look around, and make sure to join us every Monday on live Zoom. Call info here. Find us here:   Community Education Facebook : https://www.facebook.com/groups/essentialwellnesspdx/?ref=share_group_link YouTube: https://youtube.com/channel/UC63D4FzSvaJwfkDrJe5y5zw Website:  https://www.hellovisionary.life