Podcasts about ap2

In this episode, host Dr. Seema Khosla explores a provocative question in sleep medicine: Could high pressure PAP therapy have unexpected inflammatory effects? Joined by Dr. Sanja Jelic from Columbia University and Dr. Daniel Gottlieb from Brigham and Women's Hospital, the discussion examines emerging research that challenges conventional wisdom about positive airway pressure (PAP) therapy.  Discover groundbreaking findings on how PAP settings may influence inflammatory biomarkers like angiopoietin-2 (AP2) and VEGF-A, potentially explaining why cardiovascular outcomes in clinical trials haven't consistently shown improvement with PAP therapy. Learn about pressure optimization strategies, alternatives to high-pressure PAP therapy, and implications for treating 

In this episode, Pat and Konch dive into Ardian's record-breaking $30B secondaries fund, the largest ever raised. They also discuss key leadership moves, including Anna Hammer's appointment as CIO of AP2 and notable transitions across the investment world. In the RIA/FA M&A segment, highlights include Focus Financial's latest acquisitions and Gibraltar Capital's expansion into Dallas. Plus, updates on institutional searches, major Commitments from funds like LAFPP, and exciting fundraising news from Dubin Clark and Bertram Capital. Tune in for the latest insights and trends in fundraising and private markets!

Jordan Plays the Utah Open and Weston caddies Cantlay defends his BMW title and is in position to repeat as FedEx Cup champ. Sam Bennett wins US Amateur Rumors: TW is starting a circuit on the PGAT for the elite players. Involving stadiums? Tom Weiskoff passes away from pancreatic cancer - 28 pro wins - 16 PGAT Vic - 1 Major, the Open - Four 2nd place Masters Tiger back on video game 2k23 - Jordan is in the game Cantlay WITB Patrick Cantlay's winning WITB: 2022 BMW Championship Published 1 day ago on Aug 21, 2022 By GolfWRX Staff Patrick Cantlay what's in the bag accurate as of the BMW Championship. Driver: Titleist TS3 (9.5 degrees, B1 SureFit, 0.75 degree flat lie) Shaft: Mitsubishi Diamana ZF 60 TX 3-wood: Titleist 915 F (15 degrees, B1 SureFit, 0.75 degree flat lie) Shaft: Mitsubishi Diamana ZF 70 TX 5-wood: Titleist TS2 (21 degrees, B1 SureFit, 0.75 degree flat lie) Shaft: Mitsubishi Diamana 80 TX Irons: Titleist 718 AP2 (4-9) Shafts: True Temper Dynamic Gold 120 Tour Issue X100 Wedges: Titleist Vokey Design SM7 (46-10F @47, 52-08F), Titleist Vokey Design SM9 (56-08M @57, 60-T) Shafts: True Temper Dynamic Gold Tour Issue S300 Putter: Scotty Cameron Phantom X T5 Proto Ball: Titleist Pro V1x Grips: Golf Pride Tour Velvet

On this weeks episode I sit down with America Part Two, a rock band from New Jersey. We start out talking about how the band formed and got to where they are now. I was able to catch them in between their two summer tours that are promoting their new EP "AP2-niverse". "AP2-niverse" is a jam packed EP that truly does not feel like just five songs. We chat all about the EP, from the recording process to the songs they think you should check out. We also talk about the future of the band and what we can expect. To finish off the episode we go over some fun stories from their time in music. Be sure to catch America Part Two at a show near you and don't forget to listen to "AP2-niverse"!! This episode features the songs "Feel The Break" and "13 Minutes" from the album AP2-niverse. You can find America Part Two on all streaming sites and here: www.americaparttwo.com

DP World Tour: ISPS Handa Championship in Spain Spains own Pablo Larrazabal shoots 62 to top fellow Spaniard Adrian Otaegui Champions Tour: ClubCorp Classic Scott Parel survives a 3 man playoff with Steven Alker and Gene Sauer. In the Celebrity Division Marty Fish beats Tony Romo in a playoff to win. LPGA Tour: DIO Implant LA Open Nasa Hataoka dominates the field to win easily. Patrick and Xander team up tp win the Zurich. - 1,200+ days till win by Schaffle - Jay Haas Oldest to make a PGA TOUR cut Patrick Cantlay WITB Driver: Titleist TS3 (9.5 degrees)
Shaft: Mitsubishi Diamana ZF 60 TX 3-wood: Titleist 915F (15 degrees)
Shaft: Mitsubishi Diamana ZF 70 TX 7-wood: Titleist TS2 (21 degrees)
Shaft: Mitsubishi Diamana ZF 80 TX Irons: Titleist 718 AP2 (4-9)
Shafts: True Temper Dynamic Gold 120 Tour Issue X100 Wedges: Titleist Vokey Design SM7 (46-10F @47, 52-08F), SM9 (56-08M @57), SM8 Prototype (62-08M @61)
Shafts: True Temper Dynamic Gold Tour Issue S300 Putter: Scotty Cameron Phantom X 5 Prototype Ball: Titleist Pro V1x Grips: Golf Pride Tour Velvet Xander Schauffele WITB Driver: Callaway Rogue ST Triple Diamond S (10.5 degrees @9.9 degrees)
Shaft: Mitsubishi Kai'li White 70 TX 3-wood: Callaway Epic Speed Triple Diamond (15 degrees @14)
Shaft: Mitsubishi Kai'li White 70 TX 7-wood: Callaway Mavrik Sub Zero (20 degrees @18.8)
Shaft: Mitsubishi Kai'li White 90 TX Irons: Callaway Apex TCB Raw (4-PW)
Shafts: True Temper Dynamic Gold Tour Issue X100 Wedges: Callaway Jaws MD5 (52-10S), Titleist Vokey Design SM6 (56-10 @57), Titleist Vokey Design SM9 (60-06K@61)
Shafts: True Temper Dynamic Gold Tour Issue X100 Putter: Odyssey O-Works #7 CH Red
Grip: SuperStroke Traxion 2.0 Tour (10 grams) Ball: Callaway Chrome Soft X LS Prototype Grips: Golf Pride Z-Grip 15 of top 100 sign up for LIV Blue Monster in LIV rotation R&A rejects Greg Norman's Open Championship request. $5m verdict for house on golf course

We were very fortunate to have America Part Two on the podcast to talk about their new EP, "AP2-niverse". Enjoy! America Part Two Socials: Twitter: https://twitter.com/AmericaPartTwo Instagram: https://www.instagram.com/americaparttwo/ Facebook: https://www.facebook.com/AmericaPartTwo/ Apple Music: https://music.apple.com/us/artist/america-part-two/1246376947 Spotify: https://open.spotify.com/artist/4cITCQX4pPjRiy3kC0R2xe Website: https://www.americaparttwo.com/ Merch: https://mischiefnite.com/ Good Noise Podcast Socials: Twitter: https://twitter.com/good_noise_cast Instagram: https://www.instagram.com/goodnoisepodcast/ Facebook: https://www.facebook.com/goodnoisepod Discord: https://discord.gg/nDAQKwT YouTube: https://www.youtube.com/channel/UCFHKPdUxxe1MaGNWoFtjoJA Spotify: https://open.spotify.com/show/04IMtdIrCIvbIr7g6ttZHi All other streaming platforms: http://hyperurl.co/GoodNoisePodcast Patreon: https://www.patreon.com/goodnoisepodcast Bandcamp: https://goodnoiserecords.bandcamp.com/

Chris Kanik, CEO and Founder of Smart Cups, joins us on the latest episode of the Nutrastrong™ podcast. Listen in as he shares how he went from being a young chemistry wiz to stand up comedian to founder of the innovative and sustainability driven technology company, Smart Cups. In this candid interview, learn how the Smart Cups technology was established, and how it's making an impact not only in the health and wellness space, but also in humanitarian and eco-friendly applications. Plus, get an inside look at what's to come with new Smart Cups prototypes and product applications including CBD and cannabis. _____ Chris Kanik is the CEO and Founder of Smart Cups, a sustainability-driven technology company whose flagship product, an energy drink, hit the market in 2018 as the World's First Printed Beverage. Smart Cups utilizes a patented delivery system technology that allows flavors and active materials be printed on substrate surfaces. These applications can be used in a myriad of industries, including pharmaceuticals, cosmetics and more, allowing for a reduction in storage and transportation requirements resulting in a reduction of the world's overall resources. Today, Chris oversees Smart Cups' 23,000 square foot manufacturing and R&D facility in Mission Viejo, CA. Born and raised in Union City, New Jersey, Kanik's creative and entrepreneurial spirit can be directly attributed to being the first generation born of immigrant parents. Having experienced first-hand the struggles and inequalities that exist among socio-economic classes, Chris has always been drawn to disrupting the status quo and designing better solutions to systems. He first entered a lab at age 12 to study the chemical degradation of aspartame in diet sodas over extended storage periods at room temperature. At 14, he joined a research team in the Nutritional Sciences Department at Rutgers University to study adipocyte metabolism in adipocyte fatty acid binding protein (A-FABP) knockout mice (aP2-/-) after short-term high-fat feeding. His work contributed to the discovery of a functional compensation by the keratinocyte-FABP. From there, Chris went on to join a research team working on a NASA-funded project developing biologically based nano-robots at Rutgers in the Department of Mechanical and Aerospace Engineering. Rather than pursuing the conventional path after graduating from Cornell University with a BA in Economics, Chris blazed his own trail and pursued his passion for stand-up comedy on the New York circuit. His quick wit and even quicker ability to handle audiences made him a regular on the New York comedy scene. He has toured nationally at the Improv opening for some of the most popular and well-known acts. Chris has also headlined internationally and performed in front of large stadium crowds.

Weekly Tournament winners recap Korn Ferry: The finals 25 Cantlay/Bryson battle 1,200 votes 23% Bryson - 77% Patrick Landslide victory of cheering for Patrick 14.58 Strokes Gained for the week (best in shotlink era) 537 feet of putts made Patrick Cantly WITB Driver: Titleist TS3 (9.5 degrees) Shaft: Mitsubishi Diamana ZF 60 TX 3-wood: Titleist 915F (15 degrees) Shaft: Mitsubishi Diamana ZF 70 TX Hybrid: Titleist TS2 (21 degrees) Shaft: Mitsubishi Diamana ZF 80 TX Irons: Titleist 718 AP2 (4-9) Shafts: True Temper Dynamic Gold 120 Tour Issue X100 Wedges: Titleist Vokey Design SM7 (46-10F @47, 52-08F, 56-08M @57), SM8 Prototype (61) Shafts: True Temper Dynamic Gold Tour Issue S300 Putter: Scotty Cameron Phantom X 5 Ball: Titleist Pro V1x Grips: Golf Pride Tour Velvet Tiger backup sells for

John Rahm forced to WD due to Covid - has 6 shot lead at -18 - What options did the PGA Tour have??? - The cost of this forced WD? - $1.6 Million - Possible opportunity to be #1 in the world Patrick Cantlay wins in playoff over Colin Morikawa - Morikawa, new putter story. - Putting still suspect Marcus Armitage wins Porsche European Open for first Euro Tour event - Final round 65 Mito Pereira win REX Hospital Open - Secure 2022 PGA Tour Card with win! Stephen Ames win Principal Charity Classic - Edges out fellow Canadian and Utah resident Mike Weir by 1 shot 19 year old Filipino Yuka Saso wins US Women's Open in playoff over Japans Nasa Hataoka - modeled swing after Rory Mcilroy - Rory tweets: everyone will be modeling your swing - Ties youngest women victor at WUSO Olympic Club was tough but fair Lexi Thompson blows 54 hole lead - 5 over back nine - bogeys final two holes to miss playoff by one Cantlay WITB high-light - Creature of Habit Driver: Titleist TS3 (9.5 degrees @8.75, C1 setting) Shaft: Mitsubishi Diamana ZF 60 TX 3-wood: Titleist 915F (15 degrees, B1 setting) Shaft: Mitsubishi Diamana ZF 70 TX Hybrid: Titleist 816 H2 (21 degrees, B1 setting) Shaft: Fujikura Ventus Black 10 TX Irons: Titleist 718 AP2 (4-9) Shafts: True Temper Dynamic Gold 120 Tour Issue X100 Wedges: Titleist Vokey SM7 (46-10F, 52-08F, 56-08M) Titleist Vokey SM8 (61 Proto) Shafts: True Temper Dynamic Gold Tour Issue S300 Putter: Scotty Cameron Phantom X 5 Ball: Titleist Pro V1x (2019)

Episode Notes podcast #botanyafterdark #foxglove Hello, friends! Today, we're talking about foxglove, or Digitalis purpea and how it's had roles as healer, poison, and ornamental over the years. Let's discuss ^_^ f you've any topic requests, feel free to pop them in the comments below. If you'd like to see future live recordings, the lowest tier is $1, link: (https://www.patreon.com/AP2). Many thanks to my Patreon patrons and Twitch subscribers for financially supporting these projects. Global Issues: Typhoon relief for the Philippines: https://helptheph.carrd.co/ Supporting Indian Farmers: https://www.sikhcoalition.org/get-involved/take-action-tell-congress-condemn-indian-government-response-farmersprotest/ BLM Caard: https://blacklivesmatters.carrd.co/ Humanitarian Efforts in Palestine: https://www.palestinercs.org/index.php?langid=1 Helping Colombia: https://www.gofundme.com/f/soscolombia-urgent-help-for-activists-in-colombia?utm_campaign=p_cp_url&utm_medium=os&utm_source=customer COVID Support for India: https://docs.google.com/document/d/1eiobgyrl8iz-R1Dz7c4R5pzzzkuZLBj99vaC7T_UeVo/edit COVID Support for Brazil: https://www.vakinha.com.br/vaquinha/campanha-de-solidariedade-em-tempos-de-coronavirus Sources: Study talking about rapid evolution of foxglove: https://www.eurekalert.org/pub_releases/2021-04/bes-sfr040721.php University of Arkansas Foxglove article: https://www.uaex.edu/yard-garden/resource-library/plant-week/foxglove.aspx DoveMed and First Aid for Poisoning: https://www.dovemed.com/healthy-living/first-aid/first-aid-foxglove-poisoning/ SFGate: https://homeguides.sfgate.com/foxglove-toxic-70940.html WebMD article: https://www.webmd.com/vitamins/ai/ingredientmono-287/foxglove TheSpruce: https://www.thespruce.com/tall-toxic-foxglove-plants-2132588 Central Coast Biodiversity: https://www.centralcoastbiodiversity.org/common-foxglove-bull-digitalis-purpurea.html Digitalis Lantana wiki: https://en.wikipedia.org/wiki/Digitalis_lanata Digitalis purpea wiki: https://en.wikipedia.org/wiki/Digitalis Foxglove chemistry: https://www.compoundchem.com/2016/06/21/foxgloves/ GardenDoctor on Foxgloves and safety: https://gardendoctor.org/are-foxgloves-poisonous-to-touch-beautiful-but-deadly/#:~:text=Foxgloves%20are%20also%20poisonous%20to%20animals%20such%20as,plants%2C%20we%20recommend%20not%20growing%20foxgloves%20at%20all. Podcast: Main Page: https://radiopublic.com/botany-after-dark-GObMrO/s1!c66c8 iTunes: https://podcasts.apple.com/us/podcast/botany-after-dark/id1472886336 Spotify: https://open.spotify.com/show/5BDnyts9dEFMQAP1ZtBjc5 Player FM: https://player.fm/series/botany-after-dark Social Media Links: Full Linktree: https://linktr.ee/AdventuRyn Twitch: https://www.twitch.tv/adventuryn Blog: https://www.theamazingplantproject.com/ Podcast: https://radiopublic.com/botany-after-dark-GObMrO Patreon: https://www.patreon.com/AP2 Support Botany After Dark by contributing to their Tip Jar: https://tips.pinecast.com/jar/botanyafterdark Find out more at https://botanyafterdark.pinecast.co This podcast is powered by Pinecast. Try Pinecast for free, forever, no credit card required. If you decide to upgrade, use coupon code r-a19fe9 for 40% off for 4 months, and support Botany After Dark.

Episode Notes I'd wanted to do this episode earlier, but life happened. In this episode of Botany After Dark, we talk about Oleander, it's derivative Oleandrin, and the concerning nature of some people's health advice. This episode was filmed during a Patreon and Twitch subscriber-only live stream and then edited. If you'd like to see future live recordings, the lowest tier is $1, link: (https://www.patreon.com/AP2). Many thanks to my Patreon patrons and Twitch subscribers for financially supporting these projects. Blog (and sources) episode: https://www.theamazingplantproject.com/blog/2021/16/5/discussions-of-oleander-oleandrin-and-covid-19-botany-after-dark-podcast-episode-9 Video version: https://youtu.be/42acJAMFEQg Social Media Links: https://linktr.ee/AdventuRyn Twitch: https://www.twitch.tv/adventuryn Blog: https://www.theamazingplantproject.com/ Podcast: https://radiopublic.com/botany-after-dark-GObMrO Patreon: https://www.patreon.com/AP2 Support Botany After Dark by contributing to their Tip Jar: https://tips.pinecast.com/jar/botanyafterdark Find out more at https://botanyafterdark.pinecast.co This podcast is powered by Pinecast. Try Pinecast for free, forever, no credit card required. If you decide to upgrade, use coupon code r-a19fe9 for 40% off for 4 months, and support Botany After Dark.

In this episode we talk with Chris Kanik about Smart Cups, the world's first printed beverage, using a patented delivery system technology that allows flavors and active materials be printed on nearly any surface. Chris Kanik is the CEO and Founder of Smart Cups, a sustainability-driven technology company whose flagship product, an energy drink, hit the market in 2018 as the World's First Printed Beverage. Smart Cups utilizes a patented delivery system technology that allows flavors and active materials be printed on substrate surfaces. These applications can be used in a myriad of industries, including pharmaceuticals, cosmetics and more, allowing for a reduction in storage and transportation requirements resulting in a reduction of the world's overall resources. Today, Chris oversees Smart Cups' 23,000 square foot manufacturing and R&D facility in Mission Viejo, CA. Born and raised in Union City, New Jersey, Kanik's creative and entrepreneurial spirit can be directly attributed to being the first generation born of immigrant parents. Having experienced first-hand the struggles and inequalities that exist among socio-economic classes, Chris has always been drawn to disrupting the status quo and designing better solutions to systems. He first entered a lab at age 12 to study the chemical degradation of aspartame in diet sodas over extended storage periods at room temperature. At 14, he joined a research team in the Nutritional Sciences Department at Rutgers University to study adipocyte metabolism in adipocyte fatty acid binding protein (A-FABP) knockout mice (aP2-/-) after short-term high-fat feeding. His work contributed to the discovery of a functional compensation by the keratinocyte-FABP. From there, Chris went on to join a research team working on a NASA-funded project developing biologically based nano-robots at Rutgers in the Department of Mechanical and Aerospace Engineering.www.smartcups.comMy Bright Idea is a weekly interview podcast that celebrates successful small businesses and their owners who have taken the leap to make their ideas and dreams a reality.www.mybrightideapodcast.comFacebook - www.facebook.com/groups/mybrightideaInstagram - My Bright IdeaTwitter - @mybrightideapodMusic by audionautix.com

In this podcast, the PRI's Carmen Nuzzo speaks with Claudia Gollmeier, Senior Investment Officer, Managing Director, Singapore, Colchester Global Investors and Chair of the PRI's Sovereign Debt Advisory Committee and Kristian Hartelius, Head of Quantitative Strategies, AP2, and member of the advisory committee.   They discuss how ESG factors feature in risk assessment and the role of sovereign bondholders’ engagement.

In this episode, we’re going to cover a small topic of the CWAP certification. We’re taking a look at the frame exchanges that occur during 802.11r or Fast BSS Transition. In our scenario we’ll use my iPhone which associates to AP1 and roams to AP2. Without 802.11r, the roam will take additional time to complete. […] The post CTS 251 – Fast BSS Transition Frame Exchanges (CWAP) appeared first on Clear To Send.

JB Straubel is up to something new, AP2 owners get a long awaited feature, and the Unplugged Performance Tesla racing team cannot be stopped. JB Straubel’s new project - https://bit.ly/TT-E618-1 AP2+ owners get speed limit recognition - https://bit.ly/TT-E618-2 Unplugged Performance comes through - https://bit.ly/TT-E618-3 and https://bit.ly/TT-E618-3A Have a comment or question? Tweet @teslatidbits with the hashtag #AskTeslaTidbits if you'd like to be on the show, or send a message to podcast@teslatidbits.com! Support the show! Patreon - https://patreon.com/teslatidbits Pure Tesla - https://puretesla.com/tidbits - Looking for a great solution for Sentry Mode storage? These guys have your solution in three flavors. Preformatted and ready to go, they utilize either MicroSD or SSD technology for longevity and integrity of data. Interested in Cryptocoins? - https://www.coinbase.com/join/harbau_ef - Check out Coinbase for your crypto trading needs! Sign up with my link, and both of us pick up $10 when you buy or sell your first $100 worth of coins with Coinbase. Looking to buy a new Tesla? Please use the show referral code, https://ts.la/richard174 to pick up 1,000 miles of free Supercharging for your new vehicle! #Tesla #EV #ElectricCars #ModelS #Model3 #ModelX #ModelY #Roadster #CyberTruck #Autopilot #Supercharger #Gigafactory

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.10.244244v1?rss=1 Authors: Hannan, F. M., Stevenson, M., Bayliss, A. L., Stokes, V. j., Stewart, M. E., Kooblall, K. G., Gorvin, C. M., Codner, G. F., Teboul, L., Wells, S., Thakker, R. V. Abstract: Mutations of the adaptor protein-2 sigma subunit (AP2S1) gene which encodes AP2-sigma2, a component of the ubiquitous AP2 heterotetrameric complex involved in endosomal trafficking of the calcium-sensing receptor (CaSR), cause familial hypocalciuric hypercalcemia type 3 (FHH3). FHH3 patients have heterozygous AP2S1 missense Arg15 mutations (p.Arg15Cys, p.Arg15His or p.Arg15Leu) with marked hypercalcemia and occasional hypophosphatemia and osteomalacia. To further characterise the phenotypic spectrum and calcitropic pathophysiology of FHH3, we used CRISPR/Cas9 genome editing to generate mice harboring the AP2S1 p.Arg15Leu mutation, which causes the most severe FHH3 phenotype. Heterozygous (Ap2s1+/L15) mice were viable, and had marked hypercalcemia, hypermagnesemia, hypophosphatemia, and increased plasma concentrations of parathyroid hormone, fibroblast growth factor 23 and alkaline phosphatase activity, but normal pro-collagen type 1 N-terminal pro-peptide and 1,25 dihydroxyvitamin D. Homozygous (Ap2s1L15/L15) mice invariably died perinatally. The AP2S1 p.Arg15Leu mutation impaired protein-protein interactions between AP2-sigma2 and the other AP2 subunits, and the CaSR. Cinacalcet, a CaSR allosteric activator, ameliorated the hypercalcemia and elevated PTH concentrations, but not the diminished AP2-sigma2-CaSR interaction. Thus, our studies have established a mouse model with a germline loss-of-function AP2S1 mutation that is representative for FHH3 in humans, and demonstrated that cinacalcet corrects the abnormalities of plasma calcium and PTH. Copy rights belong to original authors. Visit the link for more info

In this episode of the PRI podcast, and the second to feature A Legal Framework for Impact, the PRI’s Oliva Mooney hosts Martin Jonasson, General Counsel of AP2, and Elodie Feller, Investment Lead at United Nations Environment Programme Finance Initiative (UNEP FI). They discuss what investing for sustainability impact means and why it is important. They also dig deeper with specific examples of investor approaches to managing for impact, how it goes beyond niche impact investing, the evolution in EU benchmarks, and balancing the appropriate level of returns and real-world impact. Interested in the resources discussed in this podcast? A Legal Framework for Impact A Legal Framework for Impact: in conversation with David Blood, Co-Founder and Senior Partner, Generation Investment Management

The Model Y is already getting a shakeup, Model S and X get a bump in charging capability, we see a new and welcome incoming feature for AP2 owners, and more. Model Y shakeup - https://bit.ly/TT-E609-1 and https://bit.ly/TT-E609-1A Model S/X Supercharging improvement - https://bit.ly/TT-E609-2 and https://bit.ly/TT-E609-2A New lane change feature - https://bit.ly/TT-E609-3 Alameda County in danger of new lockdowns - https://bit.ly/TT-E609-4 Battery day date slips again - https://bit.ly/TT-E609-5 Have a comment or question? Tweet @teslatidbits with the hashtag #AskTeslaTidbits if you'd like to be on the show, or send a message to podcast@teslatidbits.com! Support the show! Patreon - https://patreon.com/teslatidbits Pure Tesla - https://puretesla.com/tidbits - Looking for a great solution for Sentry Mode storage? These guys have your solution in three flavors. Preformatted and ready to go, they utilize either MicroSD or SSD technology for longevity and integrity of data. Looking to buy a new Tesla? Please use the show referral code, https://ts.la/richard174 to pick up 1,000 miles of free Supercharging for your new vehicle! #Tesla #EV #ElectricCars #ModelS #Model3 #ModelX #ModelY #Roadster #CyberTruck #Autopilot #Supercharger #Gigafactory

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.06.18.158709v1?rss=1 Authors: Schechter, M., Atias, M., Abd Elhadi, S., Davidi, D., Gitler, D., Sharon, R. Abstract: alpha-Synuclein (a-Syn) is a protein implicated in the pathogenesis of Parkinson s disease (PD). It is an intrinsically disordered protein that binds acidic phospholipids. Growing evidence supports a role for a-Syn in membrane trafficking, including, mechanisms of endocytosis and exocytosis, although the exact role of a-Syn in these mechanisms is currently unclear. Here we have investigated the role of a-Syn in membrane trafficking through its association with acidic phosphoinositides (PIPs), such as phosphatidylinositol 4,5-bisphosphate (PI4,5P2) and phosphatidylinositol 3,4-bisphosphate (PI3,4P2). Our results show that a-Syn colocalizes with PIP2 and the phosphorylated active form of the clathrin adaptor AP2 at clathrin-coated pits. Using endocytosis of transferrin, an indicator of clathrin mediated endocytosis (CME), we find that a-Syn involvement in endocytosis is specifically mediated through PI4,5P2 levels. We further show that the rate of synaptic vesicle (SV) endocytosis is differentially affected by a-Syn mutations. In accord with their effects on PI4,5P2 levels at the plasma membrane, the PD associated E46K and A53T mutations further enhance SV endocytosis. However, neither A30P mutation, nor Lysine to Glutamic acid substitutions at the KTKEGV repeat domain of a-Syn, that interfere with phospholipid binding, affect SV endocytosis. This study provides evidence for a critical involvement of PIPs in a-Syn-mediated membrane trafficking. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.05.27.119388v1?rss=1 Authors: Liu, Q., Bautista-Gomez, J., Higgins, D. A., Yu, J., Xiong, Y. Abstract: Recent genetic evidence revealed that endocytic pathway plays a major role in Parkinsons disease (PD) risk. However, the molecular mechanism of how endocytic defects contribute to dopaminergic neurodegeneration in PD is poorly understood. Here we report that LRRK2, the mutations of which are the most genetic causes of PD, binds to and phosphorylates AP2M1, the core component of endocytosis that has been recently implicated in PD risk. Our study revealed that abnormal AP2M1 phosphorylation cycle, regulated either by knockout or overexpression of LRRK2, cause endocytic defects. Our study also uncovered a novel tissue-specific regulation of AP2M1 phosphorylation by LRRK2. Further, we found that LRRK2 phosphorylation on AP2M1 mediates LRRK2-induced neuronal toxicity both in vitro in neuronal cultures and in vivo in Drosophila dopamine neurons. Importantly, AP2M1 phosphorylation levels are elevated in patient fibroblasts of both LRRK2-associated PD and sporadic PD, suggesting the clinical relevance of our finding in PD. Together, our study provides a direct mechanistic link between LRRK2, AP2 and endocytosis in PD pathogenesis. Copy rights belong to original authors. Visit the link for more info

In the last episode in our series of modern slavery podcasts, the PRI's Head of Social Issues, Bettina Reinboth speaks with Anders Stromblad, Head of Alternative Investments and External Management at AP2. There are currently 40.3 million people in modern slavery today. To bring this number close to zero by 2030, and reach the Sustainable Development Goal target 8.7, we would need to reduce the number of individuals affected by 10,000 a day.    The risks of modern slavery are increasing due to changes such as climate change, automation and migration, as they disrupt global labour markets and value chains.   In this episode, Bettina and Anders discuss how AP2 is addressing modern slavery and human trafficking across its investments, and what private equity investors can do to tackle the issue. Interested in the resources discussed in this podcast? Blueprint for Mobilizing Finance Against Slavery and Trafficking: https://www.unpri.org/social-issues/a-blueprint-for-mobilizing-finance-against-slavery-and-trafficking/5156.article  

17 Spiele in Folge hatten die Füchse Berlin gegen den TBV Lemgo gewonnen. Und es sah auch gestern Abend zunächst so aus, als würde diese Serie so weitergehen. Denn die Berliner legten mit 5:0 einen starken Start hin. Trotzdem: Am Ende setzte sich Lemgo durch ... Was war los? Was war bei den souveränen Kielern und Flensburgern los? Malte Asmus und Sebastian Mühlenhof klären euch auf. Euch gefällt dieser Podcast - oder ihr habt Kritik, Fragen oder Anregungen? Dann freuen wir uns, wenn wir von euch hören. Lasst uns gerne bei iTunes eine Rezension und ein bisschen Feedback da. Schreibt uns, was ihr gut oder auch schlecht findet, oder welche Themen wir eurer Meinung nach mal in einer Sendung behandeln sollten. Oder ihr schreibt unserem Moderator direkt per Mail (malte.asmus@meinsportpodcast.de) oder Twitter (@MalteAsmus)....

17 Spiele in Folge hatten die Füchse Berlin gegen den TBV Lemgo gewonnen. Und es sah auch gestern Abend zunächst so aus, als würde diese Serie so weitergehen. Denn die Berliner legten mit 5:0 einen starken Start hin. Trotzdem: Am Ende setzte sich Lemgo durch ... Was war los? Was war bei den souveränen Kielern und Flensburgern los? Malte Asmus und Sebastian Mühlenhof klären euch auf. Euch gefällt dieser Podcast - oder ihr habt Kritik, Fragen oder Anregungen? Dann freuen wir uns, wenn wir von euch hören. Lasst uns gerne bei iTunes eine Rezension und ein bisschen Feedback da. Schreibt uns, was ihr gut oder auch schlecht findet, oder welche Themen wir eurer Meinung nach mal in einer Sendung behandeln sollten. Oder ihr schreibt unserem Moderator direkt per Mail (malte.asmus@meinsportpodcast.de) oder Twitter (@MalteAsmus). Du möchtest deinen Podcast auch kostenlos hosten und damit Geld verdienen? Dann schaue auf www.kostenlos-hosten.de und informiere dich. Dort erhältst du alle Informationen zu unseren kostenlosen Podcast-Hosting-Angeboten.

17 Spiele in Folge hatten die Füchse Berlin gegen den TBV Lemgo gewonnen. Und es sah auch gestern Abend zunächst so aus, als würde diese Serie so weitergehen. Denn die Berliner legten mit 5:0 einen starken Start hin. Trotzdem: Am Ende setzte sich Lemgo durch ... Was war los? Was war bei den souveränen Kielern und Flensburgern los? Malte Asmus und Sebastian Mühlenhof klären euch auf. Euch gefällt dieser Podcast - oder ihr habt Kritik, Fragen oder Anregungen? Dann freuen wir uns, wenn wir von euch hören. Lasst uns gerne bei iTunes eine Rezension und ein bisschen Feedback da. Schreibt uns, was ihr gut oder auch schlecht findet, oder welche Themen wir eurer Meinung nach mal in einer Sendung behandeln sollten. Oder ihr schreibt unserem Moderator direkt per Mail (malte.asmus@meinsportpodcast.de) oder Twitter (@MalteAsmus)....

17 Spiele in Folge hatten die Füchse Berlin gegen den TBV Lemgo gewonnen. Und es sah auch gestern Abend zunächst so aus, als würde diese Serie so weitergehen. Denn die Berliner legten mit 5:0 einen starken Start hin. Trotzdem: Am Ende setzte sich Lemgo durch ... Was war los? Was war bei den souveränen Kielern und Flensburgern los? Malte Asmus und Sebastian Mühlenhof klären euch auf. Euch gefällt dieser Podcast - oder ihr habt Kritik, Fragen oder Anregungen? Dann freuen wir uns, wenn wir von euch hören. Lasst uns gerne bei iTunes eine Rezension und ein bisschen Feedback da. Schreibt uns, was ihr gut oder auch schlecht findet, oder welche Themen wir eurer Meinung nach mal in einer Sendung behandeln sollten. Oder ihr schreibt unserem Moderator direkt per Mail (malte.asmus@meinsportpodcast.de) oder Twitter (@MalteAsmus). Du möchtest deinen Podcast auch kostenlos hosten und damit Geld verdienen? Dann schaue auf www.kostenlos-hosten.de und informiere dich. Dort erhältst du alle Informationen zu unseren kostenlosen Podcast-Hosting-Angeboten.

Am Samstag tritt der 1. FC Nürnberg zum Krisengipfel bei Hannover 96 an. Vorletzter gegen Letzter. Schwächstes Heim- gegen schlechtestes Auswärtsteam. Mehr Abstiegskampf geht nicht. Doch wie ist Hannover überhaupt in dieser Situation gelandet? Nach einer erfolgreichen Vorsaison, musste man im Sommer zwar einen Leistungsträger ziehen lassen, aber nach einem Scherbenhaufen sah es nicht aus. Tobi (Hannoverliebt) berichtet bei Felix Amrhein wie es soweit kommen konnte. Wie verlief die Saison? Warum sind Länderspielpausen für Hannover-Fans ein Unding? Haben persönliche Eitelkeiten Andre Breitenreiter noch eine Woche länger im Amt gehalten? Was nährt die Hoffnung auf einen Befreiunsschlag an der Leine? Oder ist es am Ende eh alles egal, weil die anderen gewinnen und Nürnberg und Hannover sich "El Cacico" liefern? Das alles erfahrt ihr im neuen Gegnergespräch....

Am Samstag tritt der 1. FC Nürnberg zum Krisengipfel bei Hannover 96 an. Vorletzter gegen Letzter. Schwächstes Heim- gegen schlechtestes Auswärtsteam. Mehr Abstiegskampf geht nicht. Doch wie ist Hannover überhaupt in dieser Situation gelandet? Nach einer erfolgreichen Vorsaison, musste man im Sommer zwar einen Leistungsträger ziehen lassen, aber nach einem Scherbenhaufen sah es nicht aus. Tobi (Hannoverliebt) berichtet bei Felix Amrhein wie es soweit kommen konnte. Wie verlief die Saison? Warum sind Länderspielpausen für Hannover-Fans ein Unding? Haben persönliche Eitelkeiten Andre Breitenreiter noch eine Woche länger im Amt gehalten? Was nährt die Hoffnung auf einen Befreiunsschlag an der Leine? Oder ist es am Ende eh alles egal, weil die anderen gewinnen und Nürnberg und Hannover sich "El Cacico" liefern? Das alles erfahrt ihr im neuen Gegnergespräch. Du möchtest deinen Podcast auch kostenlos hosten und damit Geld verdienen? Dann schaue auf www.kostenlos-hosten.de und informiere dich. Dort erhältst du alle Informationen zu unseren kostenlosen Podcast-Hosting-Angeboten.

– Update on the status of Tesla Daily – Tesla autopilot on version 10.4 – Tesla begins invitations for Canadian Model 3 reservation holders Links: Email > tesladailypodcast@gmail.com Twitter > @teslapodcast Patreon > patreon.com/tesladailypodcast Executive producer Jerome Jorden Music by Evan Schaeffer The post 03.22.18 – Podcast Status Update, AP2 v10.4, Tesla Begins Canadian Model 3 Orders appeared first on TechCast Daily.

Cytotoxic T cells use Flower power In order to efficiently kill multiple target cells, cytotoxic T lymphocytes must endocytose and recycle cytotoxic granule membrane components from the immunological synapse. Chang et al. reveal that a protein called Flower facilitates granule endocytosis in a calcium-dependent manner. This biosights episode presents the paper by Chang et al. from the February 5th, 2018, issue of the Journal of Cell Biology and includes an interview with one of the paper's senior authors, Jens Rettig (Saarland University, Saarbrücken, Germany). Produced by Caitlin Sedwick and Ben Short. See the associated paper in JCB for details on the funding provided to support this original research. Subscribe to biosights via iTunes or RSS View biosights archive The Rockefeller University Press biosights@rockefeller.edu

While previewing the new stuff at this year's PGA Show coming up this week, Jeff extolls the virtues of the new Titleist AP irons. Whether the AP1, AP2, or AP3, one will be perfect for you, no matter how well you do or do not play

While previewing the new stuff at this year's PGA Show coming up this week, Jeff extolls the virtues of the new Titleist AP irons. Whether the AP1, AP2, or AP3, one will be perfect for you, no matter how well you do or do not play

Är det dags att starta en snällhetsrevolution bland kvinnor i svenskt näringsliv? Det är ett av samtalsämnena i EY:s senaste podd med Eva Halvarsson, vd på Andra AP-fonden ("AP2"). Eva pratar om betydelsen av att vara snäll kvinnor emellan och inom näringslivet. "Vi skulle vinna på att vara lite snällare. Vara öppnare för att se varandras styrkor och mer förlåtande för svagheter. Ingen är perfekt", menar Eva. Eva har varit vd i 11 år på AP2, en av fem buffertfonder i det svenska pensionssystemet. Under den tiden har det hänt otroligt mycket på kapitalmarknaden, men Eva menar att synen på vd-posten inte hänger riktigt med. Hon träffar fortfarande personer som utgår från att någon av hennes manliga kollegor är vd istället. Eva uttrycker att hennes ledarskap utmärks av prestigelöshet och tydliga värderingar. I vardagen på AP2 är hon omgiven av experter inom olika områden, områden där hon själv inte har egen expertis. För att lyckas behöver man våga erkänna att man inte kan allt själv, vara överens om en gemensam kultur samtidigt som det är viktigt att inse att alla medarbetare är olika och därför behöver olika ledarskap.

Professor Jon Drezner is a family medicine physician from Seattle, USA with expertise in sports medicine and sports cardiology. He shares the new international criteria for electrocardiogram (ECG) interpretation in athletes - these lead to a lower false positive rate while maintaining sensitivity. He clearly defines the key changes and what to look out for on an ECG. You can access the International ECG Criteria paper below and also check out the conference Prof. Drezner is organising in Seattle 2-3 November 2017. International ECG Interpretation Criteria - http://bjsm.bmj.com/content/early/2017/03/03/bjsports-2016-097331. Conference: “Prevention of Sudden Cardiac Death in Athletes: Sports Cardiology for the Team Physician and Cardiology Consultant” - https://uw.cloud-cme.com/Ap2.aspx?EID=4649&P=5.

Titleist 718 AP2, CB, MB Irons Review compares the three 718 tour irons to find out which one is best for your game.

Titleist Brand Ambassador Jordan Spieth can play anything he likes, but in this interview he explains why he chooses Titleist, from his new Pro V1x golf ball, to the 716 AP2 irons and Vokey SM6 wedges that he'll be trusting in his bid to win a second Green Jacket.

Native Opinion Episode  43  “Caffeinated or decaffeinated oil, Sir?” Reach our show: hosts@nativeopinion.com Twitter: @nativeopinion facebook.com/nativeopinion Call Us! 860-381-0207 This episode is dedicated to CLEAN water #NODAPL In order to fully understand the impact of water privatization, it is imperative that we understand how rare it is to find clean, drinkable freshwater. This page aims to illustrate how little actual drinkable freshwater exists around the world, as well as to show water's importance to all cultures across the globe. http://academic.evergreen.edu/g/grossmaz/murphymw/   Title: Dakota Access Ruling Postponed in DC as Archambault Lauds 'Powerful Precedent' ICTMN Staff 8/24/16 Read more athttp://indiancountrytodaymedianetwork.com/2016/08/24/dakota-access-ruling-postponed-dc-archambault-lauds-powerful-precedent-165574   Title: AMNESTY INTERNATIONAL USA: POLICE MUST PROTECT DAKOTA ACCESS PIPELINE PROTESTERS http://www.amnestyusa.org/news/press-releases/amnesty-international-usa-to-observe-north-dakota-pipeline-protests   HEALTH Segment: PREVENT WHOOPING CAUGH http://www.cigna.com/healthwellness/audio-library/whooping-cough-makes-a-comeback   Title: Keystone Leak Worse Than Thought The rupture, which went undetected by pipeline owner TransCanada, has spilled roughly 17,000 gallons of oil in South Dakota. By Alan Neuhauser | Staff Writer April 8, 2016, at 9:50 a.m. Keystone pipeline springs leak in South Dakota   http://money.cnn.com/2016/04/04/news/keystone-pipeline-oil-spill-south-dakota/ Obama, Citing Climate Change, Rejects Keystone XL http://www.usnews.com/news/articles/2015/11/06/obama-administration-rejects-keystone-xl-pipeline   Montana declares state of emergency over pipeline spill, oily drinking water http://theweek.com/speedreads/534472/montana-declares-state-emergency-over-pipelinespill-oily-drinking-water Feds say delay worsened Yellowstone River oil spill By MATTHEW BROWN Associated Press Jan 2, 2013 http://billingsgazette.com/news/local/feds-say-delay-worsened-yellowstone-river-oil-spill/article_90d7b4a0-1972-5fbe-aba4-fcc3fb1a5662.html 100s of U.S. state's oil spills not publicized AP2:09 p.m. EDT October 25, 2013 http://www.ntsb.gov/investigations/AccidentReports/Pages/pipeline.aspx                  

Titleist 716 AP2 Irons Review reveals how additional tungsten lowers the CG to give a better performing AP1 and AP2.

Chris "Buka" Martello (Argyle Park/AP2, MTV) has the rare distinction of being a non-musician who has put out two records. Buka and I go back to a strange time where kids recorded music video shows onto VHS tapes. We dig into the history of Circle of Dust, Argyle Park and his time as a producer at MTV.

Golfalot Review the Titliest AP2 714 Irons

Golfalot Review the Titleist 712 AP1 AP2 Irons

Golfalot Review the Titleist 710 AP1 and AP2 Irons

Radial glial cells are a widespread non-neuronal cell type in the developing central nervous system (CNS) of all vertebrates. In the cortex, distinct subsets of radial glial cells coexist that are either multipotent or specified towards the generation of neurons or glial cells (Malatesta et al., 2000). Radial glial cells in the cerebral cortex are also the source of a second type of neurogenic progenitors, called basal progenitors. However, whether the generation of basal progenitors occurs in a stochastic manner or whether a specific lineage of radial glial cells is specified towards the generation of these progenitors has not been previously known. To identify functionally distinct lineages of cortical radial glial cells, I developed a new strategy using fluorescence-activated cell sorting (FACS) to isolate them and study their progeny. I isolated radial glial cells by FACS from a transgenic mouse line in which green fluorescent protein (GFP) expression is under the control of the human GFAP promoter. Strikingly, GFP intensity was correlated with cell fate. Selective enrichment of cells with a higher GFP intensity separated a largely non-neurogenic from a neurogenic (low GFP-intensity) subsets of radial glial cells. Notable differences on the progeny of these distinct sets of radial glia were found. The neurogenic radial glial cells subset generated neurons directly and those that are largely non-neurogenic also gave rise to a small proportion of Tbr2-positive basal progenitors that are then neurogenic. Thus, this last subset comprises an indirect neurogenic population of radial glial cells present in the developing cortex. Microarray analysis of these distinct sets of radial glial cells revealed profound differences in their gene expression. Genes related to gliogenesis, proliferation and cell-cycle regulation were expressed at higher levels in the largely non-neurogenic set of radial glia while genes related to neurogenesis, cell adhesion, neurotransmitter secretion and axon guidance were expressed mostly in the neurogenic subset. Moreover, the set of genes expressed at higher levels in the neurogenic radial glia was down-regulated at later stages (cortical radial glia at E18). Thus, this analysis reveals differences at the transcriptional level between direct neurogenic and largely non-neurogenic radial glial cells, supporting their intrinsic lineage differences. The functional analysis of a key fate determinant for neurogenesis from radial glia discovered in this transcriptome analysis will also be presented. This gene is the transcription factor AP2γ which was expressed at significantly higher levels in radial glial cells generating basal progenitors. AP2γ is restricted to the ventricular zone (VZ)/subventricular zone (SVZ) regions of the developing cerebral cortex in the entire nervous system and is also highly expressed in primate and human cortical progenitors. Its genetic deletion within the mouse cerebral cortex results in the molecular misspecification of basal progenitors with decreased levels of Tbr2 and Math3 expression, as well as their overproliferation associated with increased cell death specifically in the occipital cortex. This causes a reduction in upper layer neuron generation with intriguing functional defects in visual acuity. Gain-of-function studies also revealed the important role of AP2γ for the adequate specification and development of basal progenitors in the cerebral cortex, while apical progenitors were not affected by the loss- and gain-of-function of this transcription factor. Thus, I show for the first time the prospective isolation of distinct radial glia subtypes in the mouse developing cortex demonstrated at the molecular and functional level.