Podcasts about gut microbiome

In this episode, Dr. Jeffrey Gladden and Dr. Emaline Brown discuss the critical role of gut health in longevity and overall well-being. They explore the Gut Zoomer test, its significance in identifying gut microbiome health, and how dietary choices impact gut health. The conversation delves into the importance of fiber, the implications of leaky gut, and the effects of alcohol on gut health. They also highlight the connection between gut health and metabolic processes, emphasizing the need for a balanced diet rich in diverse plant-based foods.   For Audience ·       Use code 'Podcast10' to get 10% OFF on any of our supplements at https://gladdenlongevityshop.com/ !    Takeaways ·       Gut health is essential for overall health and longevity. ·       Stool testing can provide insights for everyone, not just those with symptoms. ·       An altered gut microbiome is a significant marker of aging. ·       Dietary fiber, especially from plants, is crucial for maintaining gut health. ·       Hydrochloric acid plays a vital role in digestion and gut health. ·       Alcohol can negatively affect gut health and contribute to leaky gut. ·       Food serves as information for our body, influencing our health. ·       Maintaining a diverse diet can optimize nutrient status and gut health. ·       Leaky gut can lead to systemic inflammation and various health issues. ·       The gut microbiome is integral to metabolic health and hormone balance.   Chapters 00:00 Introduction to Gut Health and Testing 03:34 Understanding the Gut Zoomer Test 07:45 The Importance of Gut Microbiome for Longevity 11:49 The Role of Diet in Gut Health 15:30 Detecting Pathogens in the Gut 18:07 New Features of the Gut Zoomer Test 24:50 Leaky Gut and Its Implications 29:37 Systemic Impact of Gut Health 32:00 The Role of Gut Microbiome in Metabolic Health 34:34 Hormonal Interactions and Gut Health 38:32 Optimizing Digestion and Nutrient Absorption 44:23 The Impact of Alcohol on Gut Health 50:51 Promoting Healthy Social Interactions   To learn more about Dr. Emaline:Email: emaline.b@vibrant-wellness.com IG: @vibrantlabs Website: https://vibrant-wellness.com/ YouTube: https://www.youtube.com/channel/UCmWuVqgp3_5Hw4l2jFE2KZA Got a question for Dr. Gladden? Submit it using the link below and it might be answered in our next Q&A episode! https://form.typeform.com/to/tIyzUai7? Reach out to us at:    Website: https://gladdenlongevity.com/     Facebook: https://www.facebook.com/Gladdenlongevity/    Instagram: https://www.instagram.com/gladdenlongevity/?hl=en     LinkedIn: https://www.linkedin.com/company/gladdenlongevity    YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw    

Discover how The Tapping Solution app can help you reduce stress, manage pain, and find emotional balance with this exclusive offer for the Wellness By Design community: https://cf.thetappingsolution.com/app-download-sp-aff?fpr=jane70&fp_sid=bydesign Most chronic pain isn't just physical—but it's driven by something much deeper...Join me and my guest, Dr. David Hanscom, to learn more about why your self-critical voice may be the hidden trigger behind your persistent pain, why a top spine surgeon walked away from the operating room, and how emotions like envy, gossip, compassion, and joy all play a surprising role in your body's healing. This is a conversation that could change the way you think about pain—and how to finally move beyond it.  In this episode you'll learn: ⏰ 02:49 - Why Dr. David stopped doing back surgery  ⏰ 11:06 - Thousands of research papers point to the nervous system to resolve pain  ⏰ 20:06 - The self-critical voice (95% of us have it!) as a trigger for chronic pain  ⏰ 28:56 - Emotions, like envy, and acts, like gossip, that generate pain  ⏰ 36:10 - Compassion, altruism, peace, and joy as emotions to calm the nervous system.  ⏰ 39:08 - Connection, awareness and persistence are the key   ⏰ 45:49 - The ONE thing you can do to activate self-healing  Check out Dr. David Hanscom's Bio: David Hanscom, MD, practiced complex orthopedic spine surgery for 32 years. He quit his practice in Seattle, WA, to present his insights into solving chronic mental and physical pain. They evolved from his 15-year battle. He escaped from the ordeal and discovered that mental pain was the biggest issue. Anxiety is the pain. He is working on a new book addressing RUTs (repetitive unpleasant thoughts). He discovered they are solvable by addressing threat physiology and the cognitive component.  His book, Back in Control: A Surgeon's Roadmap Out of Chronic Pain, systematically presents well-documented treatments for chronic pain. His self-directed action plan, which reflects many successful patients' journeys, is available at www.thedocjourney.com. He launched a movement called “Dynamic Healing,” which recognizes the interactions between stress and one's coping capacity, causing sustained threat physiology. Dealing with stress more effectively and increasing the resiliency of the nervous system allows healing. He is active as a speaker, author, and consultant. His work and resources can be accessed at www.backincontrol.com.  Connect with Dr. David Hanscom: Website: https://backincontrol.com/  Facebook: https://www.facebook.com/drdavidhanscom  Instagram: https://www.instagram.com/drdavidhanscom/  X: https://x.com/DrDavidHanscom  LinkedIn: https://www.linkedin.com/in/drdavidhanscom/  YouTube: https://www.youtube.com/user/DrDavidHanscom    ***** Hi there! I am Jane Hogan, the Wellness Engineer, and the host of Wellness By Design. I spent 30 years designing foundations for buildings until the pain and inflammation of rheumatoid arthritis led me to hang up my hard hat and follow my heart. Now I blend my backgrounds in science and spirituality to teach people how to tap into the power of their mind, body and soul. I help them release pain naturally so they can become the best version of themselves.  Wellness By Design is a show dedicated to helping people achieve wellness not by reacting to the world around them but by intentionally designing a life based on what their own body needs. In this show we explore practices, methods and science that contribute to releasing pain and inflammation naturally. Learn more at https://thewellnessengineer.com Would you like to learn how to release pain by creating more peace and calm?  Download my free guided meditation audio bundle here: https://www.thewellnessengineer.com/audio-bundle  Connect with Jane:  Facebook: https://www.facebook.com/JaneHoganHealth/ Instagram: https://www.instagram.com/thewellnessengineer/

Being able to shift our mindset to understand that our body is capable of healing itself, if given the proper inputs, is a huge part of a healthy journey. Anu Simh shares more about all 9 areas that we can focus on to move our health forward. Anu Simh is a board-certified functional health coach, Ayurvedic counselor, author of Flourish from Within, and founder of 9 Arms of Wellness, a comprehensive health philosophy that addresses gut health, brain responses, and sleep disruption. Her personal experiences with gut issues, and lack of energy inspired her to develop a proprietary protocol helping busy women break free from yo-yo weight gain.Follow Anu on Instagram @9armsofwellness Visit ConfidenceThroughHealth.com to find discounts to some of our favorite products.Follow me via All In Health and Wellness on Facebook or Instagram.Find my books on Amazon: No More Sugar Coating: Finding Your Happiness in a Crowded World and Confidence Through Health: Live the Healthy Lifestyle God DesignedProduction credit: Social Media Cowboys

Legend alarm on the podcast! We are happy to welcome the Haggerty's family, Ian and Dianne, together with their son Matthew, on the podcast sharing their 30+ year journey- from being considered the hippie weirdos to leading a movement in Western Australia- showing that you can absolutely farm regeneratively at scale, in this case over 60,000 acres, with deep regeneration. Leading regenerative farmer and co-founder of Natural Intelligence Farming (NIF), the Haggertys' farm is a living example of a harmonious alignment of soil, plant, animal, and human microbiomes in farm ecosystems.They regularly take on new land, but only if they feel the land wants and needs them to manage it. In other words, they don't go looking for land, the land finds them. Often this land is extremely degraded, and they bring it back to life with the help of sheep, whose gut microbiome kickstarts regeneration, followed by well-integrated annuals.We also dive into the different water cycles they are influencing and how these have even affected local rainfall. Of course, we unpack the massive mindset shift that is fundamental in the regenerative transition, vibrations, quantum agriculture, and rebuilding local supply webs. We cover it all. More about this episode.==========================In Investing in Regenerative Agriculture and Food podcast show we talk to the pioneers in the regenerative food and agriculture space to learn more on how to put our money to work to regenerate soil, people, local communities and ecosystems while making an appropriate and fair return. Hosted by Koen van Seijen.==========================

BUFFALO, NY — September 9, 2025 — A new #research paper was #published in Volume 17, Issue 8 of Aging-US on August 1, 2025, titled “Causal relationships between gut microbiome and hundreds of age-related traits: evidence of a replicable effect on ApoM protein levels.” In this study, Federica Grosso, Daniela Zanetti, and Serena Sanna from the Institute for Genetic and Biomedical Research (IRGB) of the National Research Council (CNR), Italy, uncovered new associations between gut microbiome and the aging process. The researchers found that certain microbial characteristics may causally influence proteins in the blood linked to inflammation and heart health. These findings could help explain how age-related diseases like cardiovascular conditions and macular degeneration are influenced by changes in the gut ecosystem. The gut microbiome, the collection of microorganisms living in the digestive system, plays a major role in immune function and metabolic health. As people age, this microbial community shifts, often leading to imbalances associated with inflammation and chronic disease. To explore how these changes might affect the body, the researchers used Mendelian Randomization—a method that leverages genetic data—to test over 55,000 possible causal connections between gut microbial characteristics and age-related health indicators. The study identified 91 significant causal relationships. Among them, the researchers found that higher levels of certain gut bacteria were associated with increased risk of age-related macular degeneration. Another finding was the association between a metabolic pathway in the gut, called “purine nucleotides degradation II,” and lower levels of apolipoprotein M (ApoM), a protein that helps protect against heart disease. This result was validated using data from an independent study, strengthening the evidence. “Unlike previous studies, we performed replication analyses for the significant results using independent GWAS datasets, a fundamental step that has often been overlooked.” The study also revealed how some bacteria may affect protein levels differently depending on a person's blood type. Specifically, in individuals with blood type A, certain gut microbes that can break down a sugar called GalNAc may influence proteins related to inflammation and cardiovascular health. This suggests that personalized approaches to managing age-related diseases could consider both gut microbiota and genetic factors like blood type. The research team followed strict guidelines to reduce false findings and confirmed its key results in independent datasets. By carefully testing for reverse causality and other biases, the authors provided strong evidence that the gut microbiome can influence critical aspects of aging biology. Although more research is needed to fully understand the biological pathways involved, these findings suggest that targeting the gut microbiota might help delay or reduce age-related inflammation and disease. The study lays a foundation for future therapeutic strategies that could include diet, probiotics, or other microbiome-based interventions. DOI - https://doi.org/10.18632/aging.206293 Corresponding author - Serena Sanna - serena.sanna@cnr.it Abstract video - https://www.youtube.com/watch?v=CWky6jlHKUs Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Subscribe to the video podcast: https://www.youtube.com/@DrTazMD/podcastsHormones aren't just about menopause, they're a vital sign for your health at every age. In this episode, Dr. Taz shares her personal story of a hormone crash at 28 and reveals how gut health, nutrient quality, toxin exposure, and stress shape hormone balance from childhood through your 50s and beyond.You'll learn why teens are facing hormonal imbalances like PCOS, endometriosis, and anxiety at record rates, why birth control and IVF can be “band-aid” fixes, and how to create a lifelong plan for hormonal stability.From the cortisol-androgen loop to fertility challenges, perimenopause transitions, and the risks of synthetic hormone treatments, this episode is your complete guide to a holistic approach to hormone health.Dr. Taz shares:• Why hormone imbalances are hitting teens harder than ever before• How your gut microbiome shapes your hormone health for life• The dangerous loop between cortisol, insulin, and androgens• Why “band-aid” fixes like birth control, IVF, and HRT can backfire• How to test your hormones at any age (without spending a fortune)• The critical steps to take in your 20s, 30s, and 40s to protect your future health• Why hormone shifts affect men just as much as womenWhether you're a parent concerned about your teen, in your 20s and feeling burned out, struggling to conceive in your 30s, or navigating the hormonal shifts of midlife, this episode will give you the holistic roadmap you need to thrive.Thank you to our sponsor:Timeline is offering my listeners 20% off your first order of Mitopure. Just go to timeline.com/DRTAZConnect further to Hol+ at https://holplus.co/- Don't forget to like, subscribe, and hit the notification bell to stay updated on future episodes of hol+.Get your copy of The Hormone Shift: Balance Your Body and Thrive Through Midlife and MenopauseStay ConnectedSubscribe to the audio podcast: https://holplus.transistor.fm/subscribeSubscribe to the video podcast: https://www.youtube.com/@DrTazMD/podcastsFollow Dr. Taz on Instagram: https://www.instagram.com/drtazmd/https://www.instagram.com/liveholplus/Join the conversation on X: https://x.com/@drtazmdTikTok: https://www.tiktok.com/@drtazmdFacebook: https://www.facebook.com/drtazmd/Host & Production TeamHost: Dr. Taz; Produced by Rainbow Creative (Executive Producer: Matthew Jones; Lead Producer: Lauren Feighan; Editors: Jeremiah Schultz and Patrick Edwards)Don't forget to like, subscribe, and hit the notification bell to stay updated on future episodes of hol+Chapters00:00 My Hormone Crash Story & Why Hormones Matter at Any Age03:35 How Childhood Gut Health Shapes Hormones for Life07:25 The Teenage Hormone Crisis11:27 Birth Control Risks & The Band-Aid Problem13:48 The Cortisol-Androgen Loop of Your 20s17:56 Fertility Struggles and Hormone Shifts in Your 30s21:11 The Perimenopause Transition — Why Early Prep Matters24:58 The Menopause Conversation We're Not Having27:49 Testing, Toxins, and the Holistic Hormone Plan

Is fasting more powerful than any diet pill?! Dr Alan Goldhamer reveals how this simple practice burns belly fat, boosts energy, clears brain fog…and may even cure depression!  Dr. Alan Goldhamer is one of the world's top experts on fasting, and the Founder and Director of TrueNorth Health Center, where over 25,000 people have reversed chronic illnesses through medically supervised, water-only fasting. He is also the author of books such as, ‘Can Fasting Save Your Life?' and ‘The Pleasure Trap'.  He explains:  ⬛ How to fast without losing muscle ⬛ Why obesity is more deadly than most diseases ⬛ How to fix your body with water-only fasting ⬛ How fasting treats PCOS better than medication ⬛ Why calorie counting doesn't work ⬛ Why the ‘pleasure trap' is silently keeping you sick  Topics: 00:00 Intro 02:28 What Have You Spent Your Entire Life Doing? 03:50 What Type of Fasting Are You Referring To? 04:56 What Happens to the Body During Fasting? 12:06 What Is Autophagy? 15:21 Difference Between Fasting and Calorie Restriction 17:26 How Avoiding Carbs Supports Cognitive Function 18:31 Juice Fasting 20:08 Who Do You Recommend a 40-Day Water Fast To? 22:54 What Kind of Person Does a 40-Day Water Fast? 24:35 What Happens to Our Psychology During Fasting? 26:51 Can We Just Remove Processed Food Instead? 29:35 Why Would Anyone Do a Water Fast? 32:53 How Different Genders Respond to Fasting 37:45 How Many Meals Are Missed on a 40-Day Water Fast? 39:59 Do You Supplement During Water Fasts? 40:53 What to Eat After a Water Fast 42:12 Ads 44:22 Is There a Benefit for Healthy People to Fast? 48:09 Is Fasting Effective for Weight Loss? 49:43 Results from Fasting Studies 53:43 PCOS and the Menstrual Cycle During Fasting 57:04 Does Fasting Improve Other Areas of Life? 58:07 What's the Longest Someone Can Fast For? 59:26 Safety Concerns with Water Fasts 01:00:49 Common Misconceptions About Fasting 01:02:34 Does Fasting Remove Excess Sodium? 01:04:35 How Fasting Helps Remove Toxins 01:05:45 How Fasting Affects the Nervous System 01:06:51 How Fasting Changes Taste Buds 01:08:50 Ads 01:09:51 What's the Next Step for Curious Viewers? 01:11:51 The Biggest Lie Ruining People's Lives 01:14:56 Who Are the Patients Doing 40-Day Fasts and What Are They Struggling With? Follow Dr Alan:  Website - https://bit.ly/3VnzfYl  You can purchase Dr Alan's book, ‘Can Fasting Save Your Life?', here: https://amzn.to/4p2qTDi  The Diary Of A CEO: ⬛ Join DOAC circle here - https://doaccircle.com/  ⬛ Buy The Diary Of A CEO book here - https://smarturl.it/DOACbook  ⬛ The 1% Diary is back - limited time only: https://bit.ly/3YFbJbt  ⬛ The Diary Of A CEO Conversation Cards (Second Edition): https://g2ul0.app.link/f31dsUttKKb  ⬛ Get email updates - https://bit.ly/diary-of-a-ceo-yt  ⬛ Follow Steven - https://g2ul0.app.link/gnGqL4IsKKb  Independent research: https://alangoldhamer.tiiny.co/ Sponsors: Shopify - https://shopify.com/bartlett   SimpliSafe - https://simplisafe.com/doac to claim 50% off a new system with a professional monitoring plan and get your first month free. Vivobarefoot - https://vivobarefoot.com/DOAC with code DIARY20 for 20% off Learn more about your ad choices. Visit megaphone.fm/adchoices

TWiV reviews the major shakeup in CDC leadership, herpes simplex virus infection doubles the risk of dementia, and the prototypic crAssphage is a linear phage-plasmid. Hosts: Vincent Racaniello, Rich Condit, Brianne Barker, and Jolene Ramsey Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV CDC director ousted? (CNN) Herpes simplex infection doubles risk of dementia (J Alzheimers Res) Fishing for viruses in senile (TWiV 519) Epstein-Barr virus and MS (TWiV 869) Taking a shot at dementia (TWiV 1207) crAssphage is linear phage-plasmid (Cell Host Microbe) Crassvirales (MDPI) Timestamps by Jolene Ramsey. Thanks! Weekly Picks Brianne – Research posts on Bluesky are more original — and get better engagement Rich – Rabbits With Hornlike Growths Are Hopping Around Colorado. Are They OK? (Wiki on Shope papilloma virus) Jolene – Lessons Learned: Stories from Women Leaders in STEM Vincent – What Makes This Song Great? “Smells Like Teen Spirit” Nirvana Listener Picks Lori – Tolga bat hospital Emmett – An author recommendation: Peter Watts Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

Timestamps:- 0:00 Introduction to Gut Health & Meet Madeline Lauf 3:22 What is the Gut Microbiome? 5:49 Good Gut Bugs vs. Bad Gut Bugs 7:46 Prebiotics, Probiotics, and Their Role 10:14 Signs of Gut Trouble: Constipation & Diarrhea 12:13 Common Mistakes in Healing the Gut 13:32 Gut-Healthy Routines for Kids 15:39 The Impact of Stress and Processed Foods 21:10 The Gut-Brain Connection 24:37 Final Advice: Eat the Rainbow!   Madeline Lauf is the Founder and CEO of Begin Health, a children's gut microbiome health company.Driven by a passion to address the American health crisis, she launched Begin Health to equip parents with the knowledge, tools, and nutritional solutions needed to give the next generation the healthiest start in life.Growing up in rural America, Madeline witnessed firsthand the challenges families face in building lasting foundations for wellness. She recognizes that the demands of modern life often force difficult trade-offs between convenience and long-term health.Through market-based solutions, Madeline aims to empower families and contribute to a future where children can achieve lifelong, independent health—free from preventable chronic illness, disease, and dependence on prescription drugs.Madeline is a graduate of the University of Chicago, where she earned dual degrees in Economics and Law, Letters, and Society.   ---- Learn more about Dr. Madiha Saeed at https://holisticmommd.com, or follow her on social media @HolisticMomMD

In this conversation, Dr. Sanda Moldovan and Dr. Monisha Bhanote discuss the intricate connections between oral health, gut health, and overall well-being, particularly in the context of travel. They explore the impact of the microbiome on longevity, practical tips for maintaining health while traveling, and the importance of rituals and retreats for rejuvenation and self-care. Dr. Bhanote shares her journey from traditional medicine to integrative practices, emphasizing the need for a holistic approach to health that includes understanding cellular health.   Want to see more of The Holistic Dentistry Show? Watch our episodes on YouTube! Do you have a mouth- or body-related question for Dr. Sanda? Send her a message on Instagram! Remember, you're not healthy until your mouth is healthy. So take care of it in the most natural way.    Key Takeaways: (02:59) The Journey from Pathologist to Longevity Expert (06:04) Understanding the Microbiome's Role in Health (08:47) The Connection Between Oral and Gut Microbiomes (11:43) Travel's Impact on Microbiomes (14:46) Practical Tips for Maintaining Microbiome Health (19:00) The Connection Between Oral Health and Gut Microbiome (20:07) Travel Tips for Maintaining Oral and Gut Health (29:50) Daily Rituals for Optimal Oral Health (33:16) The Importance of Longevity Retreats (36:17) Focus on Cell Care for Better Health   Guest Info Longevity Retreats:  https://www.drbhanote.com/retreats Ebook | Removing Toxins & Optimizing Gut Health for Vibrant Wellbeing  https://shop.drbhanote.com/products/removing-toxins-optimizing-gut-health-for-vibrant-wellbeing Intagram @drbhanote Facebook @drbhanote Youtube: https://www.youtube.com/@drbhanote Pinterest:  https://www.pinterest.com/drbhanote/   Connect With Us:  AskDrSanda | YouTube BeverlyHillsDentalHealth.com | Instagram  DrSandaMoldovan.com | Instagram  Orasana.com | Instagram  

In this Huberman Lab Essentials episode, I explore intermittent fasting and time-restricted eating, highlighting the positive benefits for weight loss, metabolism, organ health, circadian rhythms and cellular repair. I explain a practical framework for designing a time-restricted eating window that aligns with your lifestyle, exercise schedule and social schedule. I also cover what breaks a fast, how to support fasting with tools like salt intake and post-meal walks, and the use of fasting-related supplements, including berberine and metformin. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Carbon: https://joincarbon.com/huberman LMNT: https://drinklmnt.com/huberman Joovv: https://joovv.com/huberman Timestamps (00:00) Intermittent Fasting, Time-Restricted Eating (TRE) (00:50) Diet, Weight Loss, Calories & Hormones (05:50) Body's Response to Eating vs Fasting, Fasting Duration (09:04) Sponsor: Carbon (10:50) Time-Restricted Feeding & Metabolic Benefits, Circadian Gene Rhythm (16:19) Optimal Meal Timing, Tool: Extend Sleep-Related Fasts (21:29) Sponsors: AG1 & LMNT (24:02) Eating Window Length, Tools: Adjusting TRE for Building Muscle, Regularity (26:55) Accelerate Transition to Fasting, Glucose Clearing, Tool: After-Meal Walk (28:36) Metformin, Berberine, Continuous Glucose Monitors; Cell Growth vs Repair, mTOR (31:46) Gut Microbiome; Transitioning to Intermittent Fasting & Individualization (34:03) Tool: 8-Hour Feeding Window & Weight Loss (35:25) Sponsor: Joovv (36:40) What Breaks a Fast?, Sugar; Tool: Using Salt to Support Fasting (39:42) Tool: Ideal Feeding Window Guidelines; Exercise & Social Considerations Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

The gut microbiome isn't just about digestion, it's the command center influencing everything from mental health and immune resilience to athletic performance and chronic disease risk. In this episode, Dr. Leo Grady unpacks the gut's far-reaching role in human health, highlighting its intricate connections with the immune and nervous systems, nutrient processing, and hormonal regulation. But this conversation goes beyond biology. Dr. Grady introduces cutting-edge innovations in artificial intelligence and genomic sequencing that are reshaping how we study and support the gut. From AI-driven digital twin models to precision dietary and lifestyle interventions, listeners will discover how technology is unlocking a future where gut health can be measured, predicted, and personalized like never before. Whether you're a clinician, health enthusiast, or simply curious about the next frontier in medicine, this episode will change the way you think about your gut and the future of healthcare itself. Key Takeaways: Every aspect of health, including metabolic disorders and mental health, is linked to the gut microbiome. Jonah utilizes advanced AI and genomic sequencing to provide comprehensive gut microbiome analysis. AI's ability to simulate dietary and lifestyle changes can inform personalized health interventions. Shifts in gut microbiome environments indicate possible precursors to diseases like Parkinson's and Alzheimer's. Personalized medicine through AI-driven insights offers an innovative approach to optimize health outcomes. More About Dr. Leo Grady, PhD: Dr. Leo Grady is an internationally recognized leader in applying AI to healthcare, with over 20 years of experience across pioneering startups and global medical companies. As CEO of Paige.ai, he guided the company to industry leadership, launching groundbreaking products worldwide and securing the first-ever FDA approval for an AI product in pathology. Today, as Founder and CEO of Jona, Dr. Grady is spearheading the use of AI and digital twin technology to decode and reshape the gut microbiome, unlocking new ways to transform human health. A prolific innovator, he has authored two books on AI, published over 100 scientific papers, and holds more than 300 patents. His work has earned him the Edison Patent Award and induction as a Fellow of the American Institute for Medical and Biological Engineering. Dr. Grady earned his Ph.D. in Cognitive and Neural Systems from Boston University and currently also serves as CEO in Residence with Breyer Capital. Website Instagram Jona Health's Instagram Facebook Jona Health's LinkedIn Connect with me! Website Instagram Facebook YouTube This episode is sponsored by Professional Co-op®, where clinicians gain exceptional access to industry-leading lab services without the hefty price tag—since 2001, they've been redefining what efficient, patient-focused support looks like. Imagine no hidden fees, no minimums, and only paying for completed tests. Experience lab services that not only meet but also exceed your expectations. Join the co-op trusted by countless licensed clinicians nationwide. Visit www.professionalco-op.com to learn more! This episode is also made possible by Functional Medicine University. FMU is a fully online, self-paced training program in functional medicine, founded in 2006 by Dr. Ron Grisanti. With students in all 50 U.S. states and 68 countries globally, FMU has become a cornerstone in advanced clinical education for healthcare practitioners. The curriculum is led by Dr. Grisanti, alongside contributions from over 70 distinguished medical experts on FMU's advisory board. Graduates earn the prestigious Certified Functional Medicine Practitioner (CFMP®) credential upon completion. FMU is also a nationally approved provider of continuing education for a wide range of licensed professionals, including MDs, DCs, DOs, NDs, acupuncturists, PAs, NPs, nurses, dietitians, pharmacists, and dentists. Whether you're looking to expand your clinical knowledge or bring a functional approach to your practice, FMU offers the tools, guidance, and certification to help you thrive. Visit www.functionalmedicineuniversity.com to learn more!

Dr. Hoffman continues his conversation with Stephen T. Talcott, Ph.D., Professor of Food Chemistry, Department of Food Science and Technology at Texas A&M University, about the powerful health benefits of the muscadine grape.

In this episode of the Intelligent Medicine podcast, Dr. Ronald Hoffman discusses the health benefits of Muscadine grapes with Dr. Stephen Talcott, a PhD chemist and professor of Food Chemistry at Texas A&M. The conversation delves into the unique biochemical properties of Muscadine grapes, their polyphenol content, and their potential health benefits compared to other fruits like Acai and common grapes. They also explore the bioavailability of nutrients, the role of phytoalexins, and the benefits of Muscadine grape-derived products. Dr. Talcott shares his insights on ongoing research at Wake Forest University, the advantages of Muscadine grape products for chemotherapy patients, and the benefits of using these products as natural health supplements. The episode highlights various Muscadine grape products available from Mighty Muscadine and Vinetastic, including juices, supplements, and topical applications, and offers a special discount code for listeners.

Digestion issues are more than just a physical problem, and struggling with these can hold you back in more ways than you might realize. Join me and my guest, Steven Wright, to learn more about how IBS nearly cost him his engineering job and the surprising root causes behind food sensitivities and gut issues. We'll dive into the mental and physical cycle of fear around food, and Steven will share the best supplements to help heal your digestion from the inside out. Don't miss out on this life-changing conversation. Tune in now and start your journey to a healthier gut today!  Save 10% on gut-supporting supplements here: https://healthygut.com/thewellnessengineer In this episode, you'll learn: ⏰ 03:26 - How gas from IBS nearly got Steven fired from his engineering job  ⏰ 11:00 - Multiple root causes of digestive problems and food sensitivities  ⏰ 17:57 - Orthorexia and developing a fear of foods and life on planet Earth  ⏰ 26:58 - When you struggle with sympathetic dominance  ⏰ 33:56 - The best supplements to help with digestive issues  ⏰ 46:13 - The ONE thing you can do to activate self-healing    Check out Steven Wright's Bio: Steven Wright is a Health Engineer, Functional Medicine Expert, and the visionary founder of The Healthy Gut Company—which exists to help people get transformational results with their gut health issues. The suite of products he's created at Healthy Gut are some of the most innovative and powerful gut health supplements in the world, resulting in more than 12,000 satisfied customers and more than 1,000 tough cases helped! The company is trusted by more than 150+ practitioners and provides a customer experience unlike any other by staffing their entire support force with Gut Health Coaches. Additionally, Steven has become a renowned voice in the gut health space, personally creating more than 30 industry-leading educational programs and contributing to over 700 research articles.  Steven Wright's gift and link: Save 10% on gut-supporting supplements here: https://healthygut.com/thewellnessengineer   Connect with Steven Wright: Website: https://healthygut.com/  Instagram: https://www.instagram.com/healthygutco/    ***** Hi there! I am Jane Hogan, the Wellness Engineer, and the host of Wellness By Design. I spent 30 years designing foundations for buildings until the pain and inflammation of rheumatoid arthritis led me to hang up my hard hat and follow my heart. Now I blend my backgrounds in science and spirituality to teach people how to tap into the power of their mind, body and soul. I help them release pain naturally so they can become the best version of themselves.  Wellness By Design is a show dedicated to helping people achieve wellness not by reacting to the world around them but by intentionally designing a life based on what their own body needs. In this show we explore practices, methods and science that contribute to releasing pain and inflammation naturally. Learn more at https://thewellnessengineer.com Would you like to learn how to release pain by creating more peace and calm?  Download my free guided meditation audio bundle here: https://thewellnessengineer.com/audiobundle Connect with Jane:  Facebook: https://www.facebook.com/JaneHoganHealth/ Instagram: https://www.instagram.com/thewellnessengineer/

View the Show Notes For This Episode Dr. Andrea McBeth discusses how Stool-derived Postbiotics can restore gut health with Dr. Ben Weitz. [If you enjoy this podcast, please give us a rating and review on Apple Podcasts, so more people will find The Rational Wellness Podcast. Also check out the video version on my WeitzChiro YouTube page.]   Podcast Highlights   In this episode of the Rational Wellness Podcast, host Dr. Ben White discusses postbiotics with Dr. Andrea McBeth, a naturopathic clinician and expert in functional gastroenterology and the microbiome. Dr. McBeth shares insights into her work with fecal microbial transplants and her development of the pheno-biotic supplement made from sterilized fecal matter. The conversation dives into the benefits of postbiotics for various gastrointestinal conditions and overall gut health, the complexities of bile acids and their roles in the body, and the emerging understanding of the microbiome's impact on brain and immune function. Dr. McBeth also highlights the stringent criteria for selecting stool donors for her supplements and announces an innovative partnership for clinical trials to gather more data on the effectiveness of postbiotics.     00:29 Meet Dr. Andrea Macbeth: Expert in Functional Gastroenterology 01:26 The Science and Benefits of Fecal Microbial Transplants 04:50 Exploring Bile Acids and Their Clinical Importance 10:02 Understanding Prebiotics, Probiotics, and Postbiotics 12:28 The Development and Benefits of Sterilized Postbiotic Products 14:36 The Apollo Wearable: Managing Stress and Improving Sleep 16:07 How Postbiotics Enhance Gut Health and Overall Wellbeing 28:01 The Role of the Microbiome in Immune Education 29:02 Postbiotics and Their Complementary Role 31:51 Clinical Trials and Data Collection 32:58 Dosage Recommendations and Usage 35:52 Probiotics vs. Fecal Microbiota Transplantation (FMT) 42:20 Misconceptions About the Gut Microbiome 48:19 Sourcing and Criteria for Donor Stool 50:04 Conclusion and Final Thoughts       ___________________________________________________________________ Dr. Andrea McBeth is the founder and CEO of Thaena, a pioneering microbiome therapeutics company. She has a Bachelor's in Biochemistry, focusing on molecular biology, and a Doctorate in Naturopathic Medicine. Early in her career, Andrea directed her ND clinical practice toward functional GI disorders and autoimmunity, launching one of the first stool banks for fecal microbiota transplantation to treat Clostridioides difficile infections.  Driven by the interface between gut microbes and human health, Andrea invented ThaenaBiotic, the first human-derived postbiotic supplement. The website is Thaena.com. Dr. Ben Weitz is available for Functional Nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure.  Dr. Weitz has also successfully helped many patients with managing their weight and improving their athletic performance, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111.

Dr. Sean Gibbons joins Dr. Buck Joffrey to discuss the complexities of the gut microbiome, its evolution, and its significant role in health and longevity. He explains how our microbiome is established at birth, how it changes throughout life, and the impact of diet and lifestyle on its composition. The discussion also covers the challenges of modifying the microbiome, the potential of precision nutrition, and the emerging field of fecal transplants. Dr. Gibbons emphasizes the importance of butyrate, a beneficial short-chain fatty acid produced by gut bacteria, and the future of microbiome research in developing targeted interventions for health improvement. Learn more about Dr. Sean Gibbons: https://isbscience.org/people/sean-gibbons-phd/?tab=biography - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/

Artificial sweeteners promise a “sugar-free” solution, but what does the science actually show? In this conversation with Emeran Mayer, we explore their impact on the gut microbiome, metabolism, and long-term health, along with how sugar cravings are formed and whether soda myths hold up. Dr. Emeran MayerListen to the full episode⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠here⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠.Watch the full episode on YouTube ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠here⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠.⁠⁠⁠***This episode is sponsored by Spatone – the No.1 iron-rich water supplement.This is a product I genuinely believe in — one I've used personally and recommended in the clinic for years. Spatone is a natural iron-rich water that's incredibly gentle on the stomach. No harsh tablets, no digestive upset — just one naturally sourced ingredient that works.If you're looking for iron support that actually feels good to take, this is the one I trust. You can pick up Spatone at Boots: ⁠⁠⁠⁠⁠⁠Spatone Apple Daily Iron Shots + Vitamin C 28 Sachets - Boots⁠⁠⁠⁠⁠⁠**This episode is also sponsored by London Nootropics, the best-in-class adaptogenic coffee I trust. Made with Hifas da Terra mushroom extracts, it supports focus, calm, and energy, and helps you stay sharp throughout the day. Enjoy 20% off with code LIVEWELLBEWELL at ⁠⁠⁠⁠⁠⁠londonnootropics.com⁠⁠⁠⁠⁠⁠***If you enjoyed this episode you might also like:The Gut-Mind Doctor: The Mind & Food Strategies That Can Heal Your Gut Microbiome | Dr. Emeran Mayerhttps://youtu.be/yL5ZtoJAUBs***Sign up to Sarah's Compassionate Cure newsletter: Science Simplified, Health Humanised. Join thousands in exploring actionable insights that prioritise compassion, clarity, and real-life impact. ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://sarahmacklin.substack.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠***Let's be friends!

Dr. Sumanta (Monty) Pal and Dr. Arielle Elkrief discuss the clinical relevance of the gut microbiome in cancer immunotherapy and the importance of antibiotic stewardship, as well as interventions currently being explored to treat gut dysbiosis and optimize immunotherapy response. TRANSCRIPT Dr. Sumanta (Monty) Pal: Hi everyone, I'm Dr. Monty Pal, welcoming you to the ASCO Daily News Podcast. I'm a medical oncologist. I'm a professor and vice chair of academic affairs at the City of Hope Comprehensive Cancer Center in Los Angeles.  Today we're here to discuss one of my favorite topics, which is the gut microbiome. It's almost hard to avoid the gut microbiome nowadays if you look at medical literature within oncology. It's an emerging phenomenon, but there are a couple of individuals that I would really define as pioneers in the field. And one of them is actually with me today, Dr. Arielle Elkrief, to discuss the clinical relevance of the gut microbiome, particularly amongst patients receiving immunotherapy, although I imagine our conversation today will take many twists and turns. Arielle is an assistant professor and clinician scientist in the Department of Oncology at the University of Montreal, and she is co-director of the CHUM Microbiome Center there.  FYI for the listeners, we have our full disclosures in the transcript of this episode.  Arielle, thank you so much for joining us today. Dr. Arielle Elkrief: Thanks so much, Monty. This is going to be amazing. Dr. Sumanta (Monty) Pal: Well, I have to tell you what sort of inspired me to bring you on as a guest. It was one of many things, but it was this really terrific ASCO Educational [Book] article that you wrote. Now, I have to tell you, I've read all the articles sort of cover to cover in the book, and they're always a wonderful primer, so if our audience is studying for board research or something of that sort, it's a terrific resource to go through. I have to tell you, this piece on the gut microbiome that you wrote is nothing short of a masterpiece. If you read this cover to cover, it's actually going to give you, I think, a sense of the current state and future state of the field. I wanted to start by just sort of beginning with sort of the origin story for a lot of this, which is this association between the gut microbiome and immunotherapy response. This takes us back several years to this pivotal series of papers in Science. Maybe you could walk our audience through that. Dr. Arielle Elkrief: Absolutely. Well, thank you so much for your kind words about the ASCO [Educational] Book. It was a team effort with a lot of key opinion leaders in the field, so I'm really glad to learn that you've liked it.  Moving backwards in terms of how we came to understand that the gut microbiome is essential to priming a response to cancer immunotherapy actually goes back to 2015 and seminal papers that looked at what happens when we take mice that are germ-free mice that have never been exposed to a microbiome. These are mice that are born by cesarean section and essentially live in a bubble. And when we give those mice tumors and treat them, in the first papers with anti-CTLA-4 treatment, we realized that these antibodies don't work at all. And that was the first observation that the presence of a gut microbiome was essential to mounting an anti-cancer immune response. When we supplemented those same mice with beneficial bacteria or feces from responder patients, we were able to restore the response to immunotherapy. And so those were really the first preclinical observations that made us understand the critical role of the microbiome in immunotherapy response. Moving a little bit in the future, we examined the fecal microbiome composition using shotgun metagenomic sequencing in different cohorts of patients with solid tumors, namely lung cancers, kidney cancers, and also skin tumors like melanoma, and found that patients who responded to immunotherapy had a distinct microbiome that was characterized by beneficial bacteria compared to patients who experienced resistance to immunotherapy that had a dysbiotic or diseased microbiome. Dr. Sumanta (Monty) Pal: So, you know, it's interesting, these techniques that we're using to sequence the gut, they're a little bit different. So I wonder if you can give the audience a quick primer on these techniques that you're so well versed in, shotgun metagenomic sequencing, 16S rRNA sequencing. If you had to describe this in 30 seconds, which is a tall task, how would you do that? Dr. Arielle Elkrief: That's a tall task. Much of what we know about the microbiome initially came from a technique called 16S rRNA sequencing. This is a technique that amplifies the 16S region and basically tells you at the genus level what's going on at the level of bacterial composition. This technique is fast, relatively cheap, and can be performed on a laptop computer, which is excellent. The problem is that it's prone to a lot of technical variations. Different primers might give you different results, and you're really limited at the genus resolution. You can't get a good resolution in terms of species, and we're learning that different species from the same genus might have different physiological properties, and the same thing goes at the strain level. So when we really zone in and look at inter-species changes, we're seeing that these actually have specific functions in the host. So that brings us to metagenomic sequencing, which is a whole genome sequencing, next-generation sequencing based method that looks at the whole composition and gives you information not only on bacteria, but you might also get fungal and viral properties. You can zoom in on the strain level. You can also get functional output, so we can examine what the metabolic properties of specific species or strains might look like. The negative aspects of shotgun metagenomic sequencing is that it takes a lot of computational power in order to analyze the results and it might take a little bit longer. And certainly, within the clinical setting, not something that's feasible yet.  And that brings us to more novel point-of-care biomarker tools that we've collaborated in developing along with Dr. Laurence Zitvogel and Dr. Lisa Derosa at Gustave Roussy, that learning from the shotgun metagenomics results designed a probe using quantitative PCR which looks for this specific bacteria we know to be important and developed a ratio of harmful bacteria to beneficial bacteria. This is called the TOPOSCORE, and it actually is able to predict quite nicely the response to immunotherapy using a stool sample and a really good turnaround time of almost 72 hours. Dr. Sumanta (Monty) Pal: That was a perfect overview and a lot of information in a short amount of time. It also makes you take out your high school biology textbooks, doesn't it, to understand that the bacterial ribosome, right, is a different size and shape, and that's what we're sequencing here. But these techniques I think are incredibly important, and I'm glad you actually discussed this, this RT-PCR based strategy of calculating the TOPOSCORE. It lends itself to this phenomenon of dysbiosis, and I think for our audience, that's going to be an important term to understand as time goes on. There's the normal healthy gut and then there's this phenomenon of dysbiosis, which is, I guess, simply put, an unhealthy gut. But tell us about, you know, how often you see dysbiosis in a cancer patient, maybe versus a normal healthy adult. Dr. Arielle Elkrief: So, I think we can split up your question into two parts. One is we know from cohort studies and population level-based studies that the microbiome of patients with cancer is distinct from healthy patients or healthy people. And we know that because of the global composition. We also think that there are diversity metrics that lend themselves to being described as dysbiotic. But we do know that the microbiome of people with cancer is distinct from healthy volunteers. That's the first point.  In terms of how frequently dysbiosis occurs in patients with cancer, it's not very well defined. We know that even among healthy people, there is a certain level of dysbiosis. Laurence in her talk mentioned that to be about 10% to 20%. And the other fascinating component is that when we're thinking about dysbiosis and the cancer associated microbiome, in terms of the species that are enriched, it's quite striking that a lot of these dysbiotic or negative bacteria are also found to be enriched in patients with metabolic disease, like cardiovascular disease, for example. And so it's unclear if dysbiosis is the cause or consequence, but there definitely seems to be a general pattern of disease when looking at the microbiome compared to healthy people. Dr. Sumanta (Monty) Pal: That's interesting. So, I'll tell you, my second favorite portion of your article, and I'll tell you my favorite portion as well in the context of this podcast, but my second favorite part was the section around antibiotic stewardship. You know, the utilization of antibiotics in a very pragmatic fashion amongst our patients. Can you describe why that's so critical in the context of the microbiome? Dr. Arielle Elkrief: Antibiotics can disrupt the gut microbiome composition. We know this from mouse studies, but also cohort studies of patients that are exposed to antibiotics. And most importantly, we know that patients who are exposed to antibiotics, either before or during the immunotherapy period, have significantly worse progression-free survival and overall survival to immunotherapy. And this is true for immunotherapy in the monotherapy setting, but also when combined with chemotherapy. What's striking is that when we look at patients who are just treated with chemotherapy, we don't see the negative outcome of antibiotics on outcome and progression-free survival and overall survival, suggesting that the negative impact of antibiotics on outcomes is really specific to immunotherapy backbones. The other important point is that this negative signal is maintained even after adjusting for standard prognostic variables in the specific malignancies that we're looking at. And then most importantly, at the mechanistic level, we were able to actually pinpoint the mechanism behind this antibiotic related dysbiosis. And we see this with a bloom of negative bacteria which induces a loss of MAd-CAM, which is an endothelial gut checkpoint immune marker, and that causes an efflux of immunosuppressive T cells, which are usually in the gut, to go straight into the tumor where they make the tumor unamenable to an immunotherapy response. And so now we finally have the mechanism as to why antibiotics are harmful and why we need to practice antibiotic stewardship. Dr. Sumanta (Monty) Pal: And just to be clear for the audience, I mean, if a patient needs antibiotics, they need antibiotics. But perhaps it just suggests that, and we have, I suppose, this predilection as oncologists, just for the minor cold or cough or what have you, we maybe should be a little bit more cognizant of whether or not antibiotics are truly necessary. Is that fair? Dr. Arielle Elkrief: Absolutely. So what we're advocating for is antibiotic stewardship, and this is the clear recommendation that we can make. So that means confirming a bacterial infection. If it's there and antibiotics are indicated, to choose the most narrow spectrum for the shortest course and constantly re-evaluate the indication of antibiotics. And of course, we need to work with our colleagues in infectious diseases who've done incredible work in antibiotic stewardship. And all along this process we also need to be mindful of other medications and polypharmacy, such as proton pump inhibitors or narcotics, for example, we think that these other medications which are frequently prescribed in our cancer population can also potentially have negative impacts on the microbiome and immunotherapy response. Dr. Sumanta (Monty) Pal: I think that's a terrific summary and big guidance for the audience.  I promised you I'd tell you my favorite part of your article, and this is this huge table. I think the table is two and a half pages long, if I remember correctly, but it's an awesome table, and I highly recommend our audience to check this out. It lists literally every therapeutic trial for the microbiome under the sun. And so it begins with the approach of fecal microbiota transplant, which I'm going to ask you to tell us about in a second, but it also hinges on a lot of really cool sort of novel therapies, live bacterial products, mixes of different microbial products. Maybe take us through this whole approach of FMT (fecal microbiota transplantation). I actually wasn't aware of the dozens of trials that you listed there in this space. It seems like it's a very active area of research. Dr. Arielle Elkrief: Definitely. So, as you alluded to, FMT or fecal microbiota transplantation is the most well studied and direct way to modify the patient's microbiome. This technique aims to replace the patient's dysbiotic microbiome with that of a healthy microbiome, either from a healthy donor volunteer that's been heavily screened, or from a patient who experienced response to immunotherapy. And, as three landmark studies so far that have been published demonstrated the potential of FMT to reduce primary resistance or secondary resistance to immunotherapy, and this has been in melanoma.  We also recently reported on the results of our FMT-LUMINate trial, which looked at patients with lung cancer and melanoma. Once again, FMT, when combined with immunotherapy was safe and led to a higher proportion of responses than we would normally expect.  We're now also looking at randomized trials that have come out. So the first being the TACITO trial in kidney cancer, which compared FMT plus pembrolizumab and axitinib to placebo in patients with RCC, and again, FMT was safe and feasible and also led to an increased progression-free survival at one year, meeting the study's primary endpoint.  And so, so far, there's a wealth of data really showing the promise of FMT when combined with immunotherapy, and we're now in the process of conducting larger randomized trials, including in melanoma with the CCTG (Canada Cancer Trials Group) in our ME17 or Canbiome2 trial, where we're going to be enrolling 128 patients with metastatic melanoma to receive FMT and standard of care immunotherapy compared to standard of care immunotherapy alone. Dr. Sumanta (Monty) Pal: You're very humble, so I've got to highlight for our audience. This was a mega grant that Arielle received to fund really the largest prospective exploration of FMT that will exist to date. So I'm really excited about that. I wish this was something we could participate in stateside.  Before we jump into the other approach, which is live bacterial products and mixes thereof, where do you see FMT going? I think that one of the perceived challenges with FMT is that it's hard to implement, right? You need to have a really robust framework when it comes to gastroenterology, the preparation's challenging. Is there a way to envision FMT use being more generalized? Dr. Arielle Elkrief: Those are great questions. So we're lucky in Canada to work with pioneers in FMT, Michael Silverman, Saman Maleki, and John Lenehan in London, Ontario, who had this really robust FMT healthy donor screening program, which literally screens for every pathogen under the sun, and we haven't had any problems with feasibility or implementing FMT in Canada. But I think that once we're going to hopefully start doing larger scale, randomized phase three studies, that we might run into problems with scalability. And I think also with regards to reproducibility, and that's the feedback that we're getting from some regulatory authorities, especially at the level of the FDA, where there are some concerns around inter- and intra-donor variability because, of course, we can't guarantee that every fecal sample is going to be the same. So that has really pushed the field to think about other strategies, such as live biotherapeutic products which take modified FMT or bacteria from stools from either healthy donors or from responder patients and basically turn them into drugs that are regulated as drugs and can then be studied in the context of investigational new drugs or products. Dr. Sumanta (Monty) Pal: I like this and, you know, I do think that there's a future for it. We just have to kind of put our heads together and figure out how to get over all of these logistical hurdles, but, you know, I agree, I think your group and others have demonstrated, especially with this trial that you're fanning out all throughout Canada, that it can potentially be done.  This is a topic that could probably go on for another couple of hours, right, especially based on the size of the table that you put together in this brilliant article, but tell us about live bacterial products or LBPs, as we call them these days. What's the current status, what's the future there? And maybe I'll give you less than two minutes here, although again, I realize it's a two-hour topic. Dr. Arielle Elkrief: You're probably better suited to speak about that because you've been one of the pioneers in terms of this. So we can think about LBPs in terms of single strain organisms, like CBM588 for an example, which your group did some amazing work in showing that, in a randomized setting, that this led to better responses than we would expect compared to just work with controls. We also know that LBPs can have multiple strains, up to 30. We're collaborating with a company called Cannabis Bioscience that is actually working on much larger communities of consortia. And so we're really excited about the direction that that's taking in terms of taking these LBPs and developing them from the drug perspective. In addition to LBPs, we know that there are other ways that we can change the microbiome, notably prebiotics, which are compounds which can have a beneficial impact on the microbiome. And one of these is camu camu, which I know your group is leading a clinical trial looking at camu camu and kidney cancer, and we're excited to see how that compares to FMT or LBPs, because that might be a potentially scalable alternative. Dr. Sumanta (Monty) Pal: That's awesome. What a terrific overview, and that was less than two minutes. I don't know how you did it. That's terrific.  Arielle, this has been such an insightful conversation. I just want to thank you for, again, a terrific article in the ASCO Educational Book. I highly recommend all of our listeners to go there and check it out, and also for sharing all these terrific insights on the podcast today. Dr. Arielle Elkrief: Thank you so much, Monty. Dr. Sumanta (Monty) Pal: And thanks to our listeners, too. If you value the insights that you heard today on the ASCO Daily News Podcast, please rate, review, and subscribe wherever you get your podcasts. Thanks, everyone. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Find out more about today's speakers:    Dr. Sumanta (Monty) Pal  @montypal Dr. Arielle Elkrief Follow ASCO on social media:     @ASCO on Twitter    ASCO on Bluesky   ASCO on Facebook     ASCO on LinkedIn     Disclosures:    Dr. Sumanta (Monty) Pal:   Speakers' Bureau: MJH Life Sciences, IntrisiQ, Peerview  Research Funding (Inst.): Exelixis, Merck, Osel, Genentech, Crispr Therapeutics, Adicet Bio, ArsenalBio, Xencor, Miyarsian Pharmaceutical  Travel, Accommodations, Expenses: Crispr Therapeutics, Ipsen, Exelixis  Dr. Arielle Elkrief: Honoraria: AstraZenica, Bristol-Myers Squibb, Merck, EMD Serono Consulting or Advisory Role: Bristol-Myers Squibb Research Funding (Inst.): Kanvas Bioscience, AstraZeneca, Merck Other Relationship: Royal College of Surgeons and Physicians of Canada, Cedar's Cancer Center (Henry R. Shibata Fellowship), Canadian Institutes of Health Research (CIHR)

Parkinson's disease has long been defined by the death of neurons in the brain. Yet, decades before tremors appear, the first signs emerge quietly in the gut. Recent evidence reveals a puzzling disappearance: microbial pathways that once produced two well-known compounds fall silent. Their absence strips away protective metabolites, erodes the intestinal barrier, and leaves neurons exposed to toxins that ignite α-synuclein fibrils. Could the vanishing of two simple vitamins be an overlooked trigger, and a potential target, in the unfolding mystery of Parkinson's disease?00:00 Introduction to Parkinson's Disease00:35 Early Signs and Gut Connection01:19 The Braak Hypothesis and Vagus Nerve02:08 Gut Microbiome and Vitamin Pathways03:10 Global Meta-Analysis and Key Findings04:37 Impact of Vitamin Deficiencies08:57 Potential for Vitamin Supplementation11:20 Conclusion and Future ImplicationsPMID: 37314861

In this episode of the Smarter Not Harder Podcast, Dr. Christine Maren joins Dr. Scott to explore the often-overlooked connections between perimenopause, gut health, and hormone balance. Together, they discuss the estrobolome, how to effectively test and interpret results, strategies to correct imbalances, and a practical framework for nutrient, gut, and hormone optimization. Join us as we delve into: What the estrobolome is and why it matters for women's health How gut health impacts hormone balance during perimenopause Testing and correction strategies for optimal results Nutrient and lifestyle changes for long-term hormonal health This episode is for you if: You're experiencing perimenopause symptoms and want science-backed solutions You suspect gut health issues may be affecting your hormones You're curious about functional medicine testing options You want a practical framework for balancing hormones naturally You can also find this episode on… Apple Podcasts: [Apple link] Spotify: [Spotify link] Find more from Dr. Christine Maren: Website: https://drchristinemaren.com/ Instagram: https://www.instagram.com/drchristinemaren Find more from Smarter Not Harder: Website: https://www.troscriptions.com/pages/podcast Instagram: https://www.instagram.com/troscriptions HOMeHOPe Symposium: https://homehope.org/homehope-symposium Get 10% Off your purchase of the Metabolomics Module by using PODCAST10 at https://www.homehope.org Get 10% Off your Troscriptions purchase by using POD10 at https://www.troscriptions.com Get daily content from the hosts of Smarter Not Harder by following @troscriptions on Instagram.

Dr. Hoffman continues his conversation with Dr. Marie-Pierre St-Onge, a nutrition scientist, the founding director of the Center for Excellence for Sleep and Circadian Research at Columbia University, and author of “Eat Better, Sleep Better.”

Dr. Marie-Pierre St-Onge, a nutrition scientist and the founding director of the Center for Excellence for Sleep and Circadian Research at Columbia University, details the intriguing relationship between diet and sleep quality, exploring how various foods and nutrients affect sleep patterns. Dr. St-Onge shares insights from her research on the Mediterranean diet, functional foods, and the impact of macronutrients like fiber, carbohydrates, and polyphenols on sleep. They also touch on the effects of caffeine and alcohol, as well as the role of psychological interventions like Cognitive Behavioral Therapy for insomnia. Practical advice and delicious recipes from her new book, “Eat Better, Sleep Better,” are highlighted to help listeners enhance their sleep through dietary changes.

Join Mark from Bella+Duke on For Pet's Sake as he chats with Holly, Chief Science Officer at Animal Biome, about the fascinating world of the gut microbiome in dogs and cats. Holly explains how gut bacteria, fungi, and viruses influence digestion, immunity, and even mental health in pets. Discover the impact of diet—raw, fresh, or kibble—on gut microbiome composition, and learn why stomach acid and fibre intake are crucial for pet wellness. Holly also shares how Animal Biome's testing services can provide personalized recommendations to balance your pet's gut health, improve immunity, and prevent disease. This episode is perfect for pet owners who want to understand how diet, environment, and microbiome health are interconnected for thriving dogs and cats.

Mark from Bella+Duke sits down with Emmanuel, founder of Treat, to explore how the gut microbiome affects pet health, allergies, and overall wellbeing on For Pet's Sake. Emmanuel shares his journey studying the gut bacteria in dogs, and how tweaking diets based on microbiome testing helped his dog recover from severe allergies. Learn how gut health influences digestion, behaviour, immunity, and chronic conditions, and why a varied, fresh diet supports a thriving microbiome. This episode also highlights the importance of environmental exposure, minimizing antibiotics, and participating in microbiome studies to advance pet science. Perfect for dog and cat owners looking to understand gut health, prevent allergies, and optimise their pet's wellbeing naturally.

Send us a textWelcome to Alternative Dog Moms - a podcast about what's happening in the fresh food community and the pet industry.   Kimberly Gauthier is the blogger behind Keep the Tail Wagging, and Erin Scott hosts the Believe in Dog podcast.CHAPTERS:Kimberly & Erin catch up on summer and yard bunnies (0:55);Dr. Margo Roman's veterinary origin story (7:56);The growing popularity of microbiome research (13:21);Healthy poop as a healing tool - and role of ozone! (16:39);Why is "mainstream medicine" so disconnected from the microbiome (28:28);Why Dr. Roman is petitioning the U.S. Supreme Court (29:35)How Dr. Roman is currently treating her own dogs' health issues (30:35);Treating CCL tears in dogs - with and without prolozone - and why full-spectrum care options matter (34:10);The pressure pet parents feel when questioning their vet - and why integrative options often go unvalidated by the mainstream veterinary community (38:03);The role of ozone in supporting healing plus more about Dr. Roman's legal battle and Dr. Roman's plea to pet parents (41:32)Science and veterinary medicine are always evolving - and shouldn't be driven by the pharmaceutical industry (47:02)New developments and treatments that Dr. Roman is excited about (56:11)Dr. Roman's experiences with a leading mainstream vet hospital (58:34)Is Dr. Roman's legal battle affecting how other integrative veterinarians approach their practice? (1:02:30)The importance of sharing experiences to showcase how nutrition and integrative care support pet health (1:06:25)LINKS DISCUSSED:Change.org Petition to support Dr. Roman (https://www.change.org/p/protect-veterinarians-upholding-their-oath-and-ethics)Supreme Court of the US docket (https://www.supremecourt.gov/search.aspx?filename=/docket/DocketFiles/html/Public/25-138.html)SocialLaw.com (https://www.socialaw.com/services/slip-opinions/slip-opinion-details/margo-roman-vs.-board-of-registration-in-veterinary-medicine)Legacy Biome - get poop from Dr. Roman's dogs (https://www.legacybiome.com/)Microbiome Restorative Therapy (https://www.mbrt.life/)MASH: Dr. Roman's vet hospital (https://www.mashvet.com/)Viome testing for humans (https://www.viome.com/)03 Vets for Pet Parents (https://o3pets.com/)SOCIAL MEDIA:Facebook.com/RawFeederLifeFacebook.com/BelieveInDogPodcastInstagram.com/RawFeederLifeInstagram.com/Erin_the_Dog_MomThanks for listening to our podcast. You can learn more about Erin Scott's first podcast at BelieveInDogPodcast.com. And you can learn more about raw feeding, raising dogs naturally, and Kimberly's dogs at KeepTheTailWagging.com. And don't forget to subscribe to The Alternative Dog Moms.

A growing body of research suggests that your gut microbiome can influence your health in a variety of subtle but important ways, and the foods you consume can have an upstream effect on the health of these trillions of microbes residing in your digestive system. An ACSH reader asks whether the widely used sweetener high fructose corn syrup should be avoided for that reason. Let's take a look.

When we think of reducing toxins in our homes, we often focus on cleaning products or plastics but hidden pesticide residues on everyday produce could be quietly contributing to our kids' toxic load.In this episode of the Natural Super Kids Podcast, we're continuing our low-tox living series with an honest conversation about pesticides, and why choosing organic matters more for children. Pesticides are everywhere — from what we eat to what we breathe in and while we can't avoid them completely, there's a lot we can do to minimise exposure, especially for our little ones.Whether your family already buys some organic produce, lives rurally near farms, or you're just beginning to learn about glyphosate and the Dirty Dozen — this episode will meet you where you are.Here's what we talk about in this episode:Why children are more vulnerable to pesticides, and how they can affect gut health, immune development, hormones, and neurodevelopmentWhat glyphosate is, and why it's one of the most concerning chemicals in our food systemHow to make smarter food swaps using the Dirty Dozen and Clean 15 lists even on a tight budgetPractical strategies for families living rurally, including how to reduce pesticide drift, set up cleaner home zones, and support detox pathways naturally

What if the stubborn health challenges you've been facing — low energy, weight struggles, mood swings, brain fog — all trace back to the same hidden source?In this eye-opening episode of Truehope Cast, we sit down with Reed Davis, Double-Board Certified Holistic Health Practitioner, Certified Nutritional Therapist, and founder of Functional Diagnostic Nutrition®. With over 10,000 clients personally guided to better health and 4,000 practitioners trained across 50 countries, Reed is a true pioneer in uncovering the root causes of chronic health issues.Reed reveals how your gut microbiome could be the missing link in solving metabolic chaos — and why treating symptoms without addressing underlying imbalances is a recipe for frustration. You'll learn:The surprising connection between gut health and metabolic dysfunctionWhy functional lab testing can reveal what traditional medicine often missesPractical, holistic strategies to restore balance from the inside outIf you've been searching for lasting solutions instead of temporary fixes, this conversation is your roadmap to sustainable wellness.

A true path to lasting healing requires more than just symptom management; it demands a comprehensive approach to your well-being. Join me and my guest, Dr. Sandra Scheinbaum, educator, clinical psychologist, author, and public speaker, founder and CEO of the Functional Medicine Coaching Academy (FMCA), to learn more about a revolutionary healthcare model that puts you at the center of your healing journey. Discover how functional medicine and the integral role of health coaches can transform your health outcomes and empower you with the support you need. Tune in to discover a new vision for healthcare and take the first step towards a healthier you! Concerned about the negative impacts of EMFs on your health?  Save up to 50% on Harmoni Pendant here: https://thewellnessengineer.com/harmoni   In this episode you'll learn: ⏰ 02:48 - Why Sandra started the Functional Medicine Coaching Academy  ⏰ 07:51  - The functional medicine model and why a health coach is an integral part  ⏰ 13:22 - How a health coach can be part of your medical team  ⏰ 20:18 - Research supports better health outcomes with health coaches  ⏰ 24:40 - Critical issues facing primary medical care  ⏰ 29:42 - How your thoughts can impact your physiology  ⏰ 32:15 - The ONE thing you can do to activate self-healing    Check out Dr. Sandra Scheinbaum's Bio: Dr. Sandra Scheinbaum trains people to become Functional Medicine health coaches, and helps practitioners and businesses hire them, because she believes that health coaches are key to combating chronic disease and reducing healthcare costs. As Founder and CEO of the Functional Medicine Coaching Academy (FMCA), Sandra is a leader in the field of health coaching education.  An educator, clinical psychologist, author and public speaker for nearly 50 years, she founded FMCA at age 65 because, rather than retiring, she's on a mission to grow the health coaching profession so that millions of people can get the support they need to lead healthier lives. Her latest book, Your Health Coach Will See You Now: Creating a Healthier Future Together, advocates for health coaching as a critical component of primary care. Dr. Sandra Scheinbaum's new book: Your Health Coach Will See You Now: https://amzn.to/46T2p8L   Connect with Dr. Sandra Scheinbaum: Website: https://functionalmedicinecoaching.org/ Facebook: https://www.facebook.com/FunctionalMedCoach/ Instagram: https://www.instagram.com/drsandi/ YouTube: https://www.youtube.com/c/FunctionalMedicineCoachingAcademy   *****   Hi there! I am Jane Hogan, the Wellness Engineer, and the host of Wellness By Design. I spent 30 years designing foundations for buildings until the pain and inflammation of rheumatoid arthritis led me to hang up my hard hat and follow my heart. Now I blend my backgrounds in science and spirituality to teach people how to tap into the power of their mind, body and soul. I help them release pain naturally so they can become the best version of themselves.    Wellness By Design is a show dedicated to helping people achieve wellness not by reacting to the world around them but by intentionally designing a life based on what their own body needs. In this show we explore practices, methods and science that contribute to releasing pain and inflammation naturally. Learn more at https://thewellnessengineer.com Would you like to learn how to release pain by creating more peace and calm?  Download my free guided meditation audio bundle here: https://thewellnessengineer.com/audiobundle   Connect with Jane:  Facebook: https://www.facebook.com/JaneHoganHealth/ Instagram: https://www.instagram.com/thewellnessengineer/

We are honored to be joined today by Dr. Barbara Paldus. Dr. Barbara Paldus is a scientist, serial entrepreneur, and the founder of Codex labs. She holds over 50 US patents and has started multiple companies in various industries, including climate monitoring and biotechnology. She hasdeveloped Codex Labs in order to deliver affordable, clinically proven skin-gut-brain solutions that support the gut microbiome and healthy skin, without sacrificing sustainability. Topics: 1. Eczema- Characteristic features of a healthy epidermal barrier - Defective skin barrier in eczema- Dry, itchy skin prone to infections- Genetic, immune, and environmental contributors to eczema pathogenesis- Filaggrin (FLG) gene mutations associated with barrier dysfunction- Other genes involved- Role of Natural Moisturizing Factor (NMF)- Role of the skin microbiome in supporting barrier function2. Traditional Care for Eczema - Topical steroid withdrawal (TSW)3. Gut Microbiome and Eczema- Dysbiosis in atopic dermatitis patients- Increased intestinal permeability4. BIA Line of Products- Prebiotic supplement- Symbiotic dietary supplement: Dermatological health probiotic blend5. ANTÜ Skin Barrier Support Supplement- L-histidine, filaggrin, and NMF production- M3: Ethnicare®- Clinical studies 6. Acne- SHAANT line and acne - Ingredients in Skin De-Stress supplement for supporting hormonal, metabolic, and psychological health7. Efficacy Panel8. Traditional Acne Treatments9. Telehealth Platform: DECODE.ME- Dermatology, diagnostics, and naturopathic treatmentsShop Codex Labs' BIA Collection Shop Codex Labs' ANTÜ Skin Barrier Support SupplementShop Codex Labs' SHAANT Collection

In the episode, we will explore a common problem with Autism- the Gastrointestinal Tract. The one consistent finding with Autism and GI is a problem exists. However, research on complicated in these complicated and complex areas of human biology despite what appears to be tight controls in the studies. However, one crucial component is missing- Light. In this episode, we will cover how biology structures order from the light input and the chaos from the environment.Major Areas include Enterochromaffin Cells, Serotonin, Aromatic Amino Acids, Vitamin D, Enteric Nervous System, the endocrine systems, and the Hypothalamic-Pitutary-Adrenal Axis.Cause of Autism: https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000662271496Su study: https://www.nature.com/articles/s41564-024-01739-1Sunlight and Vitamin D: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897598/Multi-Axis-Meta-Analysis https://www.nature.com/articles/s41598-022-21327-9Quantum Engineering 33, 54, and 55 https://www.patreon.com/DrJackKruse/postsDaylight Computer Companyuse "autism" for $25 off athttps://buy.daylightcomputer.com/RYAN03139Chroma Iight Devicesuse "autism" for 10% discount athttps://getchroma.co/?ref=autism(0:00) Autism and the GI Tract; inconsistent research; Order versus Chaos- Light and Environment and Health Conditions(3:10) The GI Tract; Gut-Brain Axis; Gut Microbiome and Various Nervous Systems(6:22) POMC; HPA; Stress example(8:19) Common Autism problems in the GI(9:23) Enterochromaffin Cells; Serotonin; Immune and Inflammation(14:09) Melanin/POMC; Clock-Timing; Omentum(16:31) Real-life Acute GI Fix; Bacteria makes Dopamine in the Gut(19:04) Vitamin D Receptors and more Clock-Timing(22:13) Obesity and Autism connection? (uncoupled systems); Biosynthesis of Vit D and specific Wavelength of Light with Shared Biological Processes- DNA, RNA, Aromatic Amino Acids(24:33) Avoiding UV Light implications(26:18) Scientific Literature; Archaea, Bacteria, Fungi, Virus; "confounding" data(30:03) Ubiquinol-7, COQ10, Thiamine Diphosphate; TCA cycles(32:38) Controls (plural) in Research and lack of Control (singular); LIGHT is GREATER than FOOD(38:27) Reviews/Ratings and Contact InfoX: https://x.com/rps47586YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAEmail: info.fromthespectrum@gmail.com

In this week's podcast Dr Arun Dhir, a gastroenterology surgeon, clinical researcher and author of Happy Gut, Healthy Weight, joins Dr Michelle Woolhouse as they delve into the crucial connection between gut health and various chronic conditions, including Gastro-oesophageal reflux disease (GORD) and its links with obesity. 1 in 5 people experience GORD on a weekly basis and in this episode, Dr Arun discusses his algorithm for investigating an individual presenting with GORD. Dr Arun also talks to the challenges of diagnosing conditions like hiatus hernias and the importance of comprehensive investigations, while offering practical advice on improving gut health through diet, stress management, and complementary therapies.  Covered in this episode: (0:46) Welcome Dr Arun Dhir  (2:30) Dr Arun's story  (7:25) “All diseases begin in the gut”  (12:16) Factors causing GORD  (18:17) Hiatus hernia  (21:39) Intra-abdominal pressure  (23:08) Helicobacter pylori  (25:35) Gut testing  (32:09) Gastrocolic reflex  (34:44) Complementary treatment options  (40:02) Low grade gastritis   (43:42) Final remarks  Find today's transcript and show notes here: https://www.bioceuticals.com.au/education/podcasts/gastro-oesophageal-reflux-disease---the-gut-microbiome-as-first-principle Sign up for our monthly newsletter for the latest exclusive clinical tools, articles, and infographics: www.bioceuticals.com.au/signup/ FX DISCLAIMER: The information provided on fx Medicine by BioCeuticals is for educational and informational purposes only. The information provided is not, nor is it intended to be, a substitute for professional advice or care. Please seek the advice of a qualified health care professional in the event something you learn here raises questions or concerns regarding your health.

Watch my first-ever conversation with a political leader on the Alloutcoach show who has also transcended business, entrepreneurship, community service, women's rights advocacy and sports science. This episode uncovers a personal story and manifestation of character and integrity of an inspiring, dynamic, and powerful leader, Hon. Leela Aheer, former Canadian Minister of Culture, Multiculturalism, and Women's rights, musician, and activist throughout her journey of transformation into becoming a business executive, entrepreneur and expert in optimizing athletic performance.In addition to lessons on sportsmanship-centered leadership in business, you will discover the difference precision medicine with multi-omics and slightest variance in our microbiome DNA can have on creating gold medalists in sports, and champions in health, training, rehabilitation and recovery.

In this episode, Dr. Jockers explores the truth about the carnivore diet—and why it's not as black and white as many claim. You'll learn how your microbiome, genetics, and blood sugar stability all play a role in whether this diet helps or harms you.   Find out why some people thrive on a meat-only approach while others crash and burn. Dr. Jockers explains how nutrient density, FODMAP sensitivity, and bile flow can make or break your results.   You'll also hear the real culprits behind heart disease, why fiber isn't always your friend, and what markers to watch if you're going long-term carnivore. This episode challenges dietary dogma—and helps you personalize what's best for your body.   In This Episode:  00:00 Debunking Myths About the Carnivore Diet 00:26 Introduction to the Carnivore Diet 01:41 Personalized Diets: Finding What Works for You 02:40 Myths and Truths About the Carnivore Diet 04:20 Nutrient Deficiencies and Blood Sugar Stability 05:23 Gut Microbiome and FODMAPs 06:42 Heart Disease and the Carnivore Diet 12:43 Potential Issues with Long-Term Carnivore Diet 18:03 Nutrient Density of Animal-Based Foods 19:56 Summary and Final Thoughts 21:01 Closing Remarks and Call to Action   Are swollen legs or ankles slowing you down? Discover the power of Lymph System Support by Pure Health Research. Crafted with natural ingredients like dandelion extract, burdock root, and bromelain, this formula unclogs your lymphatic system, reducing swelling and supporting a healthy inflammatory response.   As a special offer, try Lymph System Support risk-free today and receive a complimentary bottle of curcumin extract. Visit GetLymphHelp.com/jockers to claim yours now. Say hello to renewed vitality and goodbye to discomfort!   Hair loss isn't just about age—it's about hair follicles getting stuck. AnaGain Nu by Purality Health uses a pea sprout extract clinically shown to reactivate follicles and boost regrowth. With their micelle liposomal delivery, your body absorbs it fast and effectively. Try it risk-free with a 180-day money-back guarantee and get a buy-one-get-one-free deal at RenewYourHair.com/DRJ.   “Most of us carry dormant microbes our entire lives. They don't make us sick—until stress, poor sleep, or toxins weaken our cellular defenses and allow them to reactivate.”  ~ Dr. Jockers   Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean TuneIn Radio   Resources: GetLymphHelp.com/jockers Visit https://renewyourhair.com/drj   Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https://www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/ If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/ 

Unveiling the Gut-Brain Connection: Dr. Steven Gundry on Leaky Gut, Microbiome, and Health   In today's episode, we dive deep into the fascinating world of the gut-brain connection with Dr. Steven Gundry, a prolific author and expert on the subject. Starting with a brief introduction about our sponsor, Kyndryl, we explore the historical context of medical insights from figures like Hippocrates and Ignaz Semmelweis. Dr. Gundry shares compelling stories from his practice, including miraculous patient turnarounds attributed to gut health. We discuss the latest in microbiome research, the concept of leaky gut, and how our gut's terrain influences overall health. Learn about the critical role of bacteria in our body's ecosystem, the intelligence of microorganisms, and their impact on our well-being. Join us as we unlock the secrets of a balanced inner terrain and its implications for a healthier life.   00:00 Introduction and Sponsor Message 00:30 Dedications and Historical Insights 02:06 Guest Introduction: Stephen Gundry 03:04 Remarkable Patient Stories 07:19 The Gut-Brain Connection 12:52 Historical Debate: Pasteur vs. Bechamp 16:58 Microbiome Discoveries and Implications 19:08 Bacterial Intelligence and Communication 26:29 Elephant Communication and Eavesdropping 27:04 Understanding Leaky Gut 27:52 Aging Research and Sea Elegans 29:45 The Role of Tight Junctions in Gut Health 32:46 Impact of Diet and Antibiotics on Gut Health 36:44 Environmental Toxins and Autoimmune Diseases 37:40 Lipopolysaccharides and Immune Response 42:03 The Rise of Food Sensitivities and Allergies 47:05 Gut Microbiome and Food Cravings 48:10 Conclusion and Resources Find Steven: https://drgundry.com

Concerned about the negative impacts of EMFs on your health?  Save up to 50% on Harmoni Pendant here: https://thewellnessengineer.com/harmoni You might believe being a "realist" is your superpower, but what if it's actually keeping you stuck in a loop of discomfort? Join me to discover the hidden implications of this mindset, explore the fascinating science behind your mind's connection to physical pain, and unlock the secret to activating your body's natural healing abilities. Tune in now and start your journey towards self-healing with this info and the bonus guided practice inside!   In this episode, you'll learn: ⏰ 00:00 - Introduction ⏰ 00:31 - Are you a realist? ⏰ 03:13 - What being a “Realist” really means ⏰ 04:17 - The proven science around the mind-body connection with pain ⏰ 10:51 - A guided practice to experience the mind-body connection ⏰ 16:29 - The ONE thing you can do to activate self-healing    Jane's gift and link: Order my new book, Pain-Free on Purpose, and get your bonus resources here: https://thewellnessengineer.com/book ***** Hi there! I am Jane Hogan, the Wellness Engineer, and the host of Wellness By Design. I spent 30 years designing foundations for buildings until the pain and inflammation of rheumatoid arthritis led me to hang up my hard hat and follow my heart. Now I blend my backgrounds in science and spirituality to teach people how to tap into the power of their mind, body and soul. I help them release pain naturally so they can become the best version of themselves.  Wellness By Design is a show dedicated to helping people achieve wellness not by reacting to the world around them but by intentionally designing a life based on what their own body needs. In this show we explore practices, methods and science that contribute to releasing pain and inflammation naturally. Learn more at https://thewellnessengineer.com Would you like to learn how to release pain by creating more peace and calm?  Download my free guided meditation audio bundle here: https://thewellnessengineer.com/audiobundle   Connect with Jane: Facebook: https://www.facebook.com/JaneHoganHealth/ Instagram: https://www.instagram.com/thewellnessengineer/

Dr. Mark Pimentel, Executive Director of the MAST program at Cedars-Sinai in Los Angeles, shares groundbreaking insights into the small intestinal microbiome that challenge long-held beliefs about gut bacteria. Findings from his team's REIMAGINE study reveal that the small intestine is far from sterile, as previously thought—instead, it harbors substantial bacterial communities that play a critical role in health and disease, especially in conditions such as IBS and SIBO.• E. coli and Klebsiella act as aggressive "Ferrari" bacteria that outcompete other microbes and destroy microbial diversity when overgrown inducing a "apocalyptic" disruption of the small bowel microbiome.• Lactobacillus, commonly found in many probiotics, may act as a disruptor in the small intestine and new research correlates higher small intestinal levels with obesity and unhealthy aging (more research needed)• The PLACIDE trial found probiotics didn't reduce C. diff or antibiotic-associated diarrhea but did increase bloating• Food poisoning is the only proven cause-and-effect trigger for IBS, with stress acting as a modifier rather than initiator• Combining rifaximin with NAC works 10x better for SIBO by targeting bacteria in both intestinal fluid and mucus• A new compound (CS06) shows promise for reducing methane production and relieving constipation• Three distinct gas patterns (hydrogen, methane, hydrogen sulfide) correlate with different symptom patterns and respond to targeted treatmentsThis episode was sponsored by Salix Pharmaceuticals. Resources: DDW 2025 Abstracts by the Mast Program and Dr. PimentelA Novel Microbiome Therapy, CS-06 (MTD Blocker), Reduces Methane Production in Stool CultureReal World Study of Three-Gas Breath Testing Nationwide and The Association with SymptomsLearn more about Kate and Dr. Riehl:Website: www.katescarlata.com and www.drriehl.comInstagram: @katescarlata @drriehl and @theguthealthpodcastOrder Kate and Dr. Riehl's book, Mind Your Gut: The Science-Based, Whole-body Guide to Living Well with IBS. The information included in this podcast is not a substitute for professional medical advice, examination, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider before starting any new treatment or making changes to existing treatment.

Concerned about the negative impacts of EMFs on your health?  Save up to 50% on Harmoni Pendant here: https://thewellnessengineer.com/harmoni It is not a secret that your genes hold powerful secrets to unlocking faster healing and overcoming chronic pain. What if the key to your chronic pain wasn't just about managing symptoms, but was hidden in your DNA? Join me and my guest, Dr. Sam Shay, DC, IFMCP, to learn more about a revolutionary approach to healing. From his own incredible journey of overcoming childhood trauma and chronic illness, Dr. Shay unveils the 5 interconnected types of pain—including the genetic links that could be holding you back. This conversation might just change the way you think about pain forever. Listen to the full episode now! In this episode you'll learn: ⏰ 03:09 - Early childhood trauma led to a career in functional neurology ⏰ 18:20 - The five contributing factors causing chronic pain ⏰ 28:42 - The real function of pain ⏰ 37:20 - Emotional and physical pain in the brain ⏰ 45:21 - The most important genes to test for chronic pain ⏰ 57:04 - The ONE thing you can do to activate self-healing Check out Dr. Sam Shay's Bio:Dr. Sam Shay, DC, IFMCP, is a functional medicine expert who solves complex health puzzles by helping people exit survival mode and reclaim their energy, brain health, and resilience through personalized, data-driven genetics and functional lab testing. After struggling with severe fatigue, anxiety, addiction, chronic pain, and digestive issues from ages 6 to 18, Dr. Sam took control of his health as a teenager and has spent over 25 years studying nutrition, mind-body medicine, and functional testing. He holds three bachelor's degrees, a Doctorate in Chiropractic, a postgraduate diploma in Acupuncture, and is certified by the Institute for Functional Medicine. Known as the "friendly lab nerd," Dr. Sam has been featured on over 100 podcasts and summits, especially for his novel approach to genetics. He created the Neuro-Harmony Model and DNA Decoded Program — clear frameworks that help people navigate complex health journeys without overwhelm. Outside of medicine, Dr. Sam is also a stand-up comic, using humor to educate about life on the Spectrum. His one-hour show, NeuroSpicy: Love, Life, & Comedy on the Spectrum, premiered at the 2024 Denver Fringe Festival and received over 40 five-star reviews. Dr. Sam Shay, DC, IFMCP's gift and link:Start your journey from merely surviving to truly thriving with Dr. Sam Shay's Free 3-Day Nutrition & Lifestyle Guide. Backed by over 20 years of clinical experience, this guide offers simple, effective strategies to help you boost your energy, improve your resilience, and take actionable steps toward better health. You'll receive expert advice tailored to real-life challenges and only get product recommendations from trusted sources. It's the perfect starting point for anyone ready to feel better, think clearer, and live more fully. Get your free guide today at https://go.drsamshay.com/freebie  Connect with Dr. Sam Shay, DC, IFMCP:Website: https://drsamshay.com/ Facebook: https://www.facebook.com/sam.shay.792/ Instagram: https://www.instagram.com/drsamshay/ YouTube: https://www.youtube.com/tenpointwellness LinkedIn: https://www.linkedin.com/in/dr-sam-shay-dc-ifmcp-922133128/  ***** Hi there! I am Jane Hogan, the Wellness Engineer, and the host of Wellness By Design. I spent 30 years designing foundations for buildings until the pain and inflammation of rheumatoid arthritis led me to hang up my hard hat and follow my heart. Now I blend my backgrounds in science and spirituality to teach people how to tap into the power of their mind, body and soul. I help them release pain naturally so they can become the best version of themselves.  Wellness By Design is a show dedicated to helping people achieve wellness not by reacting to the world around them but by intentionally designing a life based on what their own body needs. In this show we explore practices, methods and science that contribute to releasing pain and inflammation naturally. Learn more at https://thewellnessengineer.com Would you like to learn how to release pain by creating more peace and calm?  Download my free guided meditation audio bundle here: https://thewellnessengineer.com/audiobundle Connect with Jane: Facebook: https://www.facebook.com/JaneHoganHealth/ Instagram: https://www.instagram.com/janehoganhealth  

Struggling with chronic illness, autoimmune disease, or gut and liver issues? Discover the real root cause of your symptoms and how to heal naturally—physically, emotionally, and spiritually.In this episode with Dr. Jason Mulder, we dive deep into the layers of true healing—way beyond symptom band-aids and quick fixes.Dr. Mulder shares his powerful journey from poverty and personal trauma to becoming a leading holistic doctor, known for successfully treating complex chronic diseases, autoimmune conditions, and even end-stage cancer.We talk about the body's intuitive wisdom, the healing power of the gut and liver, and why many people stay stuck in survival mode rather than stepping into lasting wellness.If you've been told “everything looks normal” but still feel off... this episode is for you. You'll gain insight, encouragement, and tools to finally trust your body again and take charge of your healing.Even if your environment feels toxic or you've been stuck for years, there's still a way forward—starting with small steps.Whether you're facing fatigue, inflammation, gut issues, or emotional wounds, this conversation will leave you with hope, clarity, and a renewed path toward health.Chapters:[00:00] Podcast Preview[01:24] Topic and Guest Introduction[03:08] Dr. Jason's Journey to Holistic Health[08:23] Understanding Cellular Wisdom[11:55] Chronic Disease and Autoimmunity[14:34] The Importance of Root Causes[17:50] Proactive Health Strategies[20:59] Comprehensive Patient Evaluation[24:53] Healing Through Nutrition and Mental Health[27:20] The Role of Technology in Healthcare[30:02] Cultural Influences on Health Perceptions[33:25] The Impact of Food Quality on Health[34:22] Understanding Liver Health and Detoxification[38:35] The Gut Microbiome and Its Connection to Overall Health[44:10] Navigating Health in Unhealthy Environments[48:55] Connect with Dr. Jason Mulder[50:35] Conclusion and Resources

Let's talk about a topic that's been on many parents' minds lately — the rising rates of cancer in young people, and what that means for our children's future health.This week on the Natural Super Kids Podcast, we're reflecting on the Four Corners report Generation Cancer, which highlights some confronting statistics. But instead of letting fear take the lead, we're unpacking the key takeaways from a naturopathic perspective with calm, clarity, and practical ways forward.In this episode, we explore the connection between modern lifestyle habits and long-term health risks — and how we can begin laying strong, simple foundations for our kids' wellbeing without panic or pressure.Here's what we cover:What the “Generation Cancer” report reveals about cancer trends in young people including which types are increasing the most.The role of gut health, nutrition, and toxins in long-term disease prevention (and what we know from research so far).The link between antibiotic overuse, the gut microbiome, and immune vulnerability and what parents can do instead.How to take a more thoughtful, empowered approach to everyday choices like food, cleaning products, plastics, and more.How to make realistic, gentle shifts in your child's environment without fuelling health anxiety.

Your gut microbiome affects everything from your mental health and cognitive function to your immune system and metabolic health. Gut health symptoms, such as bloating, gas, constipation, or diarrhea, could be a sign that you have low species diversity. Dr. Will Bulsiewicz and Mike Haney discuss how the gut and brain communicate, how the gut microbiome affects the gut barrier and therefore your immune system, what to eat to improve the gut microbiome, and what microbiome testing can tell you.Sign Up to Get Your Free Ultimate Guide to Glucose: https://levels.link/wnl

In this episode, I sit down with Christina O'Connor, RD, Senior Healthcare Account Manager at Pendulum Therapeutics, to explore one of the most fascinating—and overlooked—players in gut health: Akkermansia muciniphila. Christina shares how Pendulum became the first company in the U.S. to commercialize live Akkermansia, a keystone probiotic strain with far-reaching effects on blood sugar, weight, mood, inflammation, and energy. Topics we cover: ✅ How gut health is at the root of not just digestion, but metabolic health, immune resilience, mood, energy, and longevity. ✅ Why live Akkermansia muciniphila — a next-generation probiotic strain Pendulum pioneered — is transforming the way we approach gut and metabolic care. ✅ Why the question people should be asking isn't “What's the best probiotic?” — but rather “What probiotic supports metabolic health? Because that's the best probiotic.” (Hint: the answer is Pendulum.) ✅ How Pendulum is bridging ancient wisdom around gut health with cutting-edge science, backed by clinical studies and rigorous manufacturing. ✅ How caring for the gut can help people better navigate blood sugar balance, cravings, healthy weight, energy, digestion, sleep, and mood. Whether you're dealing with blood sugar imbalances, unexplained fatigue, emotional ups and downs, or weight plateaus, this episode will expand the way you think about gut health. ✨ Get a discount on your order by using code CLAUDIA at pendulumlife.com Follow the host, Claudia, on Instagram, check out HealingTheSource.co & Elham's Liquid Gold 100% Organic Castor Oil, and enjoy her deep-dives on Substack

The gut microbiome is a HOT topic in ALL areas of health. Unsurprisingly, the bacteria that live in your intestines have a HUGE impact on kidney stones. Join Melanie with oxalate microbiome researcher Dr. Aaaron Miller for a fascinating episode about how bacteria help (or hinder) your kidney stone prevention efforts and most importantly, what you can do about it!  More About Dr. Aaron Miller   Submit a question for Melanie to answer on the podcast! Connect with The Kidney Dietitian! Work with Us! |  Instagram | Facebook | Pinterest | Facebook Group | Newsletter www.thekidneydietitian.org FREE Webinar: The 3-Step Method to Prevent Kidney Stones All information in this podcast is meant for educational purposes only and should not be used in place of advice from a medical professional.  

What happens when a vegan restaurateur becomes a regenerative cattle rancher and homeschooling mom? In this groundbreaking episode of The Homeschool How To Podcast, Cheryl interviews Mollie Englehart, a trailblazing voice in regenerative farming, food sovereignty, and natural living.Mollie owned five successful vegan restaurants in Los Angeles—until her journey into composting, soil health, and motherhood unraveled everything she once believed about food, nutrition, and the environment.

Send us a textEpisode Summary: Dr. Eugene Chang talks about the microbiome's role as a vital organ, the impacts of antibiotics and Western diets on microbial health, and strategies for restoring a damaged microbiome through diet and fecal microbial transplants. They delve into microbiome dysbiosis, its links to modern diseases, and Chang's research on personalized microbiome interventions.About the guest: Eugene Chang, MD is a physician-scientist and Professor of Medicine at the University of Chicago, specializing in gastroenterology. His research focuses on the gut microbiome as a vital organ influencing metabolic and immune health.Discussion Points:The gut microbiome is a vital organ, acquired early in life, that supports metabolic and immune functions, but can be disrupted by antibiotics, leading to diseases like C. difficile colitis.Western diets, high in saturated fats and low in fiber, contribute to microbiome dysbiosis, linked to modern conditions like inflammatory bowel diseases, obesity, and allergies.Microbiome health is better assessed by functional markers (e.g., short-chain fatty acid production) than taxonomic diversity, as diversity varies widely among healthy individuals.A patient with severe food intolerance due to antibiotic-induced microbiome damage was treated over 50 weeks with a tailored diet, restoring healthy microbiome function.Different dietary fibers (e.g., beans vs. seaweed) are metabolized at varying rates, affecting gut health; fermented foods like kefir can bypass digestion issues.Diet can rapidly reshape the microbiome within 24-48 hours, but severe dysbiosis may require microbial transplants if key microbes are extinct.Chang's research shows a high-fiber, low-fat diet outperforms fecal microbial transplants in restoring microbiome resilience in mice post-antibiotics.Future microbiome medicine may involve personalized “omni microbial transplants” targeting both small and large intestines for comprehensive restoration.Related episode:M&M 203: Metagenomics, Microbiome Transmission, Gut Microbiome in Health & Disease | Nicola Segata*Not medical advice.Support the showAll episodes, show notes, transcripts, and more at the M&M Substack Affiliates: KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off Readwise: Organize and share what you read. 60 days FREE through link SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. MASA Chips—delicious tortilla chips made from organic corn & grass-fed beef tallow. No seed oils or artificial ingredients. Code MIND for 20% off For all the ways you can support my efforts

This week, the cells that vanish when we slim down: are these the link between obesity and health problems like diabetes? Also, the bacteria that might be able to shield us from the "forever chemicals" we're all eating. Plus, why will 3 days over the next month be a millisecond shorter than they should be? Like this podcast? Please help us by supporting the Naked Scientists

While "The 7" team is off for the holiday, you can still read the newsletter version of the seven most important and interesting stories you need to know here. And we are bringing you another useful listen today. The Washington Post's Cristina and Dr. Trisha Pasricha break down what the microbiome is, where it lives, and how it influences everything from digestion to disease. It's the first episode of The Post's latest season of "Try This." Pasricha explains how the gut microbiome acts as a key player in our overall health and why fiber may be one of the most underrated tools in supporting it. She also offers insight into what science currently understands about gut function and what's still being uncovered.Read more of Pasricha's work, including 8 tips to improve gut health and why probiotics can be a waste of money. For more advice, follow her on Instagram. Now “Try This” has a newsletter! Think of it as a supplemental guide and sign up here.Subscribe to The Washington Post or connect your subscription in Apple Podcasts.

Dr. Harold McGee, PhD, is a renowned author on the topics of food chemistry and culinary science. He explains how cooking methods, types of cookware and temperature can be used to transform food and drink flavors and presents simple but powerful ways to improve nutrient availability. We also discuss how our individual biology, genetic and cultural backgrounds shape our taste preferences. Whether you're a seasoned cook or someone who simply loves to eat, our conversation will change how you think about food and cooking, give you actionable tools to try and deepen your appreciation of the experience of eating and drinking. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman Our Place: https://fromourplace.com/huberman Mateina: https://drinkmateina.com/huberman Function: https://functionhealth.com/huberman Timestamps 00:00:00 Harold McGee 00:02:21 Food Chemistry, Using Copper, Modern vs Traditional Techniques 00:09:59 Sponsors: Eight Sleep & Our Place 00:13:33 Cooking, Food & Heat, Taste & Smell 00:22:10 Umami, Savory Tastes, Braising & Meat 00:29:56 Chemistry of Cooking & Eating, Sugars & Conjugates; Slowly Enjoying Food 00:36:14 Savory Meal & Dessert; Food Course Order; Palate Cleansers 00:43:56 Salt, Baseline & Shifting Taste Preferences 00:47:18 Sponsors: AG1 & Mateina 00:50:07 Whole vs Processed Foods, Taste & Enjoyment 00:53:37 Brewing Coffee, Water Temperature, Grind Size 01:00:33 Tea & Tannins, Growing Tea Plants; Tea & Meals, Polyphenols 01:08:16 Food Combinations, Individual Tolerance; Is there an Optimal Diet? 01:11:34 Onions & Garlic, Histamines, Tool: Reduce Crying when Cutting Onions 01:13:55 Gut Sensitivities & Food, Capsaicin & Spicy Foods 01:17:21 Supertasters & Taste Buds, Bitter Taste, Chefs 01:21:57 Sponsor: Function 01:23:45 Salt & Bitter, Salting Fruit, Beer or Coffee, Warming Beer 01:26:11 Human History of Alcohol & Chocolate 01:29:25 Wine Expense vs Taste, Wine Knowledge 01:35:49 Cheese Making, Aged Cheese & Crystals, Tyrosine; Smoke Flavors, Distilling 01:44:30 Fermentation, “Stink Fish”, Caviar, Traditional & New Foods 01:50:42 Personal Journey, Astronomy, Poetry & Food 01:54:55 Beans & Gas, Tool: Soaking Beans 01:57:23 Gut Microbiome, Fermented Foods; Kids & Food Aversions 02:00:47 Cilantro & Divergent Tastes; Microwave Popcorn, Parmesan Cheese 02:04:46 John Keats Poetry, To Autumn; Acknowledgements 02:10:48 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

In this Huberman Lab Essentials episode, I discuss interoception, the brain's ability to sense and interpret signals from the body, which shapes our sense of self and underlies vital functions like focus, sleep, healing and emotions. I explain how the body communicates different types of information to the brain, influencing processes like digestion, heart rate and immune function. I also describe practical tools such as breathwork to regulate alertness, strategies to support gut health and reduce sugar cravings, and awareness practices to enhance interoception. By understanding and applying these tools, you can strengthen the brain-body connection to improve mood, overall health and performance. Read the episode show notes at hubermanlab.com. Huberman Lab Essentials are short episodes focused on essential science and protocol takeaways from past full-length Huberman Lab episodes. Watch or listen to the full-length episode at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman LMNT: https://drinklmnt.com/huberman Timestamps 00:00:00 Sense of Self, Interoception 00:01:25 Brain & Body Communication, Vagus Nerve, Mechanical & Chemical Information 00:04:43 Lungs & Diaphragm, Tool: Breathwork for Alert or Calm 00:09:47 Sponsors: AG1 & Eight Sleep 00:13:14 Brain & Gut Communication, Tool: Reduce Sugar Cravings 00:18:27 Brain, Gut Chemistry, Inflammation & Gut Microbiome, Tool: Fermented Foods 00:22:20 Sponsor: LMNT 00:23:52 Vomiting, Brain; Tool: Reduce Nausea 00:28:52 Fever, Brain Chemistry, Tool: Cooling Body 00:33:20 Vagus Nerve, Emotions, Mood, Tool: Heart Awareness 00:39:29 Recap & Key Takeaways Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices