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Summer Sprint starts June 2nd. Sign up today!Join the Focused Visionary Accelerator today (FVA)! FVA is your go to program if you are a business owner ready to scale to the next level. You will receive expert guidance, personalized coaching, a supportive community and live masterclasses!______________________________________________________Today, we're diving into that funky feeling of uncertainty that's got everyone asking, "Is this really what I want to be doing?" I mean, seriously, it's like a collective existential crisis out there! We're chatting about how, in the wild world of business, it's crucial to not just stay focused, but to also have a blast while doing it. I'll share my own journey of reflection and how I've realized that business should be fun, not just a grind. So, if you're feeling stuck or like you're in a rut, let's explore how to bring the joy back into what we do, and trust me, it's all about meeting people where they're at and having a good time while we're at it! Buckle up, it's going to be a spicy one!________________________________________________________Want to stay connected to Michelle - Join the Sunday Morning Brew Crew! The Sunday Morning Brew is your private invitation to actionable insights that simplify your business, spark new ideas, and help you scale—without the burnout.Connect with Michelle on Facebook or Linkedin
Join the Focused Visionary Accelerator today (FVA)! FVA is your go to program if you are a business owner ready to scale to the next level. You will receive expert guidance, personalized coaching, a supportive community and live masterclasses!_____________________________________________________Takeaways: Executive dysfunction can make it tough to focus and finish tasks, but understanding it is key. Most entrepreneurs deal with some level of executive dysfunction, so you're definitely not alone in this! Breaking big tasks into tiny steps is crucial for tackling overwhelming projects and avoiding shutdowns. Creating a routine that works with your brain's natural rhythms can help manage executive dysfunction effectively. It's okay to ask for help and lean on your support system when navigating these challenges. Remember, managing executive dysfunction doesn't make you less capable; it just means your brain works differently. Links referenced in this episode:add.org
Join the Focused Visionary Accelerator today (FVA)! FVA is your go to program if you are a business owner ready to scale to the next level. You will receive expert guidance, personalized coaching, a supportive community and live masterclasses!Learn more about the Focused Visionary Accelerator in Episode 302___________________________________________________________Ever had that moment where you're like, 'What if I just gave up and went back to my day job?' Yeah, me too! In this episode, we explore the idea that having a Plan B can actually keep us from fully investing in Plan A. Plan B often leads to self-sabotage, as it's easy to dip back into old safety nets instead of pushing forward. We reflect on how fear of failure and success can creep in, causing us to hesitate and hold back. ________________________________________________Want to stay connected to Michelle - Join the Sunday Morning Brew Crew! The Sunday Morning Brew is your private invitation to actionable insights that simplify your business, spark new ideas, and help you scale—without the burnout.Connect with Michelle on Facebook or Linkedin
Join the Focused Visionary Accelerator today (FVA)! FVA is your go to program if you are a business owner ready to scale to the next level. You will receive expert guidance, personalized coaching, a supportive community and live masterclasses!Learn more about the Focused Visionary Accelerator in Episode 302 __________________________________________Structure is a funny thing, right? We all say we want it, but the second we start to implement it, it feels like a straightjacket. In this episode, I get real about my own struggles with structure and how it can feel like a battle between our desire for freedom and the accountability that comes with having a plan. We reflect on the energy drain that comes from an unstructured business, where everything feels urgent and nothing gets done efficiently. The key takeaway? Structure doesn't have to mean rigidity. Let's find out how we can create a loose framework that allows for both accountability and creativity, helping our businesses thrive without feeling like we're trapped.Want to stay connected to Michelle - Join the Sunday Morning Brew Crew! The Sunday Morning Brew is your private invitation to actionable insights that simplify your business, spark new ideas, and help you scale—without the burnout.Connect with Michelle on Facebook or LinkedinTake the "Where's the Gap in Your Business Growth Strategy Quiz?"
Join the Focused Visionary Accelerator today (FVA)! FVA is your go to program if you are a business owner ready to scale to the next level. You will receive expert guidance, personalized coaching, a supportive community and live masterclasses!Want to learn more about FVA? Listen to Episode 302 for a Behind The Scenes deep dive!________________________________________________Today, we're diving into the nitty-gritty of stepping into that oh-so-fancy CEO role, and spoiler alert: hiring help isn't the magic bullet you think it is! We're here to chat about why pulling the trigger on hiring too soon can actually backfire on you. So many folks jump to the conclusion that being a CEO means just delegating tasks, but let's be real, if you're not ready to lead, hiring just becomes a fancy way to pay for busywork. We'll break down what it truly means to embrace that CEO mindset, focusing on clarity, systems, and making data-driven decisions. _____________________________________________________Want to stay connected to Michelle - Join the Sunday Morning Brew Crew! The Sunday Morning Brew is your private invitation to actionable insights that simplify your business, spark new ideas, and help you scale—without the burnout.Connect with Michelle on Facebook or Linkedin
Today's chat is all about diving deep into the Focused Visionary Accelerator and its eight core foundations, basically, your roadmap to business growth and scaling! We're peeling back the curtain, no gatekeeping here! Whether you're a newbie who just took the “Where's the Gap in Your Business Strategy?” quiz or a seasoned listener who hasn't yet taken the plunge, this behind the scenes is for everyone. We're not just talking theory; we're sharing actionable steps and golden nuggets to help you fill those gaps and get your business on the fast track to growth. So, grab your worksheets and a pen, it's time to roll up our sleeves and get to work!Join the Focused Visionary Accelerator today (FVA)! FVA is your go to program if you are a business owner ready to scale to the next level. You will receive expert guidance, personalized coaching, a supportive community and live masterclasses!
Join the Focused Visionary Accelerator today (FVA)! FVA is your go to program if you are a business owner ready to scale to the next level. You will receive expert guidance, personalized coaching, a supportive community and live masterclasses!________________________________________________There's a whole lot of chaos and uncertainty swirling around these days, and in this episode, we're diving deep into why staying focused is the real power move. Instead of panicking and making those knee-jerk decisions that can lead to a wild goose chase, we're chatting about the importance of strategic clarity during these tumultuous times. I'll share my own close call with the temptation to slash prices and pivot offers just because the market feels shaky. Guess what? It's all about keeping your eye on the prize and not letting fear dictate your moves! ___________________________________________________Want to stay connected to Michelle - Join the Sunday Morning Brew Crew! The Sunday Morning Brew is your private invitation to actionable insights that simplify your business, spark new ideas, and help you scale—without the burnout.Connect with Michelle on Facebook or Linkedin
Join the Focused Visionary Accelerator today (FVA)! FVA is your go to program if you are a business owner ready to scale to the next level. You will receive expert guidance, personalized coaching, a supportive community and live masterclasses!__________________________________________Let's be real: hitting six figures could mean $100,000 or a whopping $999,000, and those numbers come with entirely different business vibes and strategies. I get it; we all want that six-figure badge of honor, but today we're breaking down the reality behind it, including why $100K might not be the safety blanket we think it is. Spoiler alert: it's all about the journey of sustainable growth, not just chasing after the next shiny number in the sky. Takeaways: Chasing six figures is all the rage, but there's a huge difference between hitting $100k and $999k in business. The journey to multiple six figures often gets misunderstood; it's not just about reaching a number but understanding what that number means for your business. Hustle can get you to six figures, but to scale beyond that, you need a solid strategy that aligns with where you want to go. Not everyone wants to hit seven figures, and that's perfectly fine—focus on what makes sense for your business and lifestyle. Want to stay connected to Michelle - Join the Sunday Morning Brew Crew! The Sunday Morning Brew is your private invitation to actionable insights that simplify your business, spark new ideas, and help you scale—without the burnout.Connect with Michelle on Facebook or Linkedin
Join the Focused Visionary Accelerator today (FVA)! FVA is your go to program if you are a business owner ready to scale to the next level. You will receive expert guidance, personalized coaching, a supportive community and live masterclasses!______________________________________________Scaling your business is a hot topic, but let's face it, most business owners aren't ready to hop on that train yet. Today, we're diving deep into the difference between growth and scaling, and spoiler alert: if your revenue feels like a rollercoaster and client delivery is a bit of a hot mess, you're still in growth mode, and that's totally OK! We'll break down why trying to scale too early can lead to burnout and could even tank your profits. Takeaways: Scaling too soon can cause more harm than good, leading to business collapse. The difference between growth and scaling is crucial for sustainable success in business. It's totally okay to be in the growth stage, so don't rush into scaling just yet. Predictable revenue and a solid foundation are essential before considering any scaling actions. __________________________________________________Have questions or need some clarity - Book a FREE Clarity and Action Session! 30 Minutes and guaranteed to walk away with an immediate action step you can take to move your business!
Join the Focused Visionary Accelerator today (FVA)! FVA is your go to program if you are a business owner ready to scale to the next level. You will receive expert guidance, personalized coaching, a supportive community and live masterclasses!___________________________________________________Want the scoop on my Q1? Let's just say it wasn't all sunshine and rainbows, think more hibernation vibes with a dash of playing small. I'm diving deep into the truth behind those highs and lows, and how I'm shaking off the cobwebs. If you've ever felt like you're just coasting instead of really thriving, trust me, you're not alone! So grab your favorite drink, kick back, and let's chat about breaking out of that comfort zone and stepping into the spotlight. It's time to ditch the invisibility cloak and embrace the big, bold versions of ourselves!Connect with me on SubstackWant to stay connected to Michelle - Join the Sunday Morning Brew Crew! The Sunday Morning Brew is your private invitation to actionable insights that simplify your business, spark new ideas, and help you scale—without the burnout.Connect with Michelle on Facebook or Linkedin
Join the Focused Visionary Accelerator today (FVA)! FVA is your go to program if you are a business owner ready to scale to the next level. You will receive expert guidance, personalized coaching, a supportive community and live masterclasses!_______________________________________________________Feeling a bit overwhelmed in your business? We've all been there, and it might just be because you're battling the wrong season! Just like nature, businesses have their own cycles, and trying to juggle growth, launches, and rebuilding all at once is a recipe for chaos. In this chat, we're diving into how to pinpoint the season your business is in so you can align your focus and plan like a pro. No more scrambling! We'll help you figure out if it's time to sell, create, or simply take a breather. ______________________________________________________Want to stay connected to Michelle - Join the Sunday Morning Brew Crew! The Sunday Morning Brew is your private invitation to actionable insights that simplify your business, spark new ideas, and help you scale—without the burnout.Connect with Michelle on Facebook or Linkedin
Join the Focused Visionary Accelerator today (FVA)! FVA is your go to program if you are a business owner ready to scale to the next level. You will receive expert guidance, personalized coaching, a supportive community and live masterclasses!_____________________________________________________Doubt is sneaky! It creeps into our lives and businesses, often disguising itself as procrastination or the infamous "I'll wait until I'm ready" excuse. In this episode, we dive deep into how doubt holds us back from taking action and making decisions. I share a personal story about my own struggles with self-doubt, especially when it comes to stepping into rooms where I feel like I don't belong. But here's the kicker: successful people feel doubt too, but they don't let it stop them. So, let's chat about how we can recognize doubt, push through it, and finally say, “Heck yes, I'm ready!”________________________________________________________Related Episodes: Ep. 249: Reconnecting with Your VisionWant to stay connected to Michelle - Join the Sunday Morning Brew Crew! The Sunday Morning Brew is your private invitation to actionable insights that simplify your business, spark new ideas, and help you scale—without the burnout.Connect with Michelle on Facebook or Linkedin
Join the Focused Visionary Accelerator today (FVA)! FVA is your go to program if you are a business owner ready to scale to the next level. You will receive expert guidance, personalized coaching, a supportive community and live masterclasses!____________________________________________________If you've ever held back from sharing your thoughts or expertise because you were worried about what others might think, this episode is your wake-up call. We chat about how some folks with less skill are snagging clients simply because they're out there making noise, while we might be overthinking our every move. It's time to ditch that fear of judgment and start embracing our inner CEO because guess what? Your uniqueness is what will attract the right clients! So let's get loud, get visible, and, most importantly, get ready to own our brilliance without holding back._____________________________________________________Related Episodes & MentionsEp. 204: Embracing Your Unique Path and Defying the “Should” MentalityJulie Costa Activate Membership______________________________________________________Want to stay connected to Michelle - Join the Sunday Morning Brew Crew! The Sunday Morning Brew is your private invitation to actionable insights that simplify your business, spark new ideas, and help you scale—without the burnout.Connect with Michelle on Facebook or Linkedin
En 2025, les obligations concernant les vignettes à apposer sur le pare-brise des véhicules en France ont évolué :Vignette Crit'Air :La vignette Crit'Air est désormais essentielle pour circuler dans les Zones à Faibles Émissions (ZFE), instaurées dans les agglomérations de plus de 150 000 habitants depuis le 1ᵉʳ janvier 2025. Cette pastille classe les véhicules selon leur niveau d'émissions polluantes. Son absence lors de la circulation dans une ZFE peut entraîner une amende de 68 €. Vignette d'assurance :Depuis le 1ᵉʳ avril 2024, l'obligation d'afficher la vignette verte d'assurance sur le pare-brise a été supprimée. Les forces de l'ordre vérifient désormais la validité de l'assurance via le Fichier des Véhicules Assurés (FVA). Cependant, la souscription à une assurance automobile reste obligatoire. Vignette du contrôle technique :Bien que le contrôle technique demeure obligatoire pour les véhicules âgés de plus de quatre ans, l'apposition de sa vignette sur le pare-brise n'est plus requise. En cas de contrôle routier, il est toutefois nécessaire de présenter le procès-verbal attestant de la validité du contrôle technique. Autres vignettes :Selon les communes, d'autres vignettes peuvent être exigées, notamment pour le stationnement résidentiel ou l'accès à certaines zones spécifiques. Il est donc recommandé de se renseigner auprès des autorités locales pour connaître les obligations particulières. En résumé, en 2025, la vignette Crit'Air est la principale vignette à apposer obligatoirement sur le pare-brise dans les zones concernées. Les vignettes d'assurance et de contrôle technique ne sont plus obligatoires sur le pare-brise, mais les obligations d'assurance et de contrôle technique demeurent. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.
Join the Focused Visionary Accelerator today (FVA)! FVA is your go to program if you are a business owner ready to scale to the next level. You will receive expert guidance, personalized coaching, a supportive community and live masterclasses!_______________________________________________________We're diving into a sneaky little problem that might just be sabotaging your sales: you might be talking over your audience! Yep, that's right. If you've been pouring your heart into explaining your offer but still getting crickets, this episode is totally for you. We're breaking down why people aren't buying and it's not because your offer lacks value; it's likely that your audience just doesn't get it yet. Confused people don't buy, right? So, let's simplify your messaging and make sure your audience is left saying, "Whoa, I totally need this!" ______________________________________________Related Episodes: Ep 245: How to Avoid Confusing Your Audience Want to stay connected to Michelle - Join the Sunday Morning Brew Crew! The Sunday Morning Brew is your private invitation to actionable insights that simplify your business, spark new ideas, and help you scale—without the burnout.Connect with Michelle on Facebook or Linkedin
In an FVA season finale matchup, Kimberly took on Appleton East. Kimberly defeated Appleton East 75-60. Tony Giordana and Dick Knapinski were on the call.
Join the Focused Visionary Accelerator today (FVA)! FVA is your go to program if you are a business owner ready to scale to the next level. You will receive expert guidance, personalized coaching, a supportive community and live masterclasses!____________________________________________________Let's face it – sales can feel like a dirty word, right? But in this episode, we're flipping the script! We chat about the common fears that hold us back from selling – you know, that cringe-worthy feeling of being pushy or annoying. But guess what? Selling isn't about convincing people; it's about helping them see the value in what you offer. Think of it as sharing a great secret with a friend! We dive deep into the mindset shifts you need to make to feel confident and authentic in your sales approach. Remember, it's not about you – it's about how you can help others. So, whether you're feeling like a sales ninja or a total newbie, this episode is packed with insights that'll change your perception of selling and help you connect better with your audience. Tune in and let's turn that sales frown upside down!____________________________________________________Related Episodes: Ep 201: 3 Reasons Your SAles are DownEp. 216: Sales AND Marketing - Your Business Needs Both____________________________________________________Want to stay connected to Michelle - Join the Sunday Morning Brew Crew! The Sunday Morning Brew is your private invitation to actionable insights that simplify your business, spark new ideas, and help you scale—without the burnout.Connect with Michelle on Facebook or Linkedin
Join the Focused Visionary Accelerator today (FVA)! FVA is your go to program if you are a business owner ready to scale to the next level. You will receive expert guidance, personalized coaching, a supportive community and live masterclasses!____________________________________________Are you feeling overwhelmed by all the information out there when trying to start something new? This podcast dives into the common tendency to get stuck in the learning phase, where we consume endless content without taking action. Using a personal experience with sourdough baking as an analogy, I emphasize the importance of picking a trusted resource and just diving in. Instead of getting bogged down by the multitude of opinions and methods, the key takeaway is to learn by doing. It's time to stop absorbing and start taking action, because the real learning happens when you roll up your sleeves and get started._____________________________________________Want to stay connected to Michelle - Join the Sunday Morning Brew Crew! The Sunday Morning Brew is your private invitation to actionable insights that simplify your business, spark new ideas, and help you scale—without the burnout.Connect with Michelle on Facebook or LinkedinLinks referenced in this episode:littlespoonfarm.com
Join the Focused Visionary Accelerator today (FVA)! FVA is your go to program if you are a business owner ready to scale to the next level. You will receive expert guidance, personalized coaching, a supportive community and live masterclasses!-----------------------------------------------------------------------------We're diving into the wild world of social media and how it's totally okay to feel burnt out by it! Seriously, if you've been scrolling and feeling like it's just a never-ending cycle of content creation, you're not alone. We're chatting about how to flip the script and see social media as a tool to start, continue, and amplify conversations instead of a grind to churn out posts. Related Episodes: Ep 267: How to avoid Burnout by Focusing on One Business Strategy Ep. 280: 5 Non-Social Media Visibility Strategies for 2025 (or any year) ___________________________________________________________Want to stay connected to Michelle - Join the Sunday Morning Brew Crew! The Sunday Morning Brew is your private invitation to actionable insights that simplify your business, spark new ideas, and help you scale—without the burnout.Connect with Michelle on Facebook or Linkedin
Join the Focused Visionary Accelerator today (FVA)! FVA is your go to program if you are a business owner ready to scale to the next level. You will receive expert guidance, personalized coaching, a supportive community and live masterclasses!__________________________________________Are you constantly feeling frustrated because you're not hitting your client goals? Wondering why other business owners seem to convert more clients than you? This episode is your answer. Today, we're breaking down why your audience size truly matters and how understanding the game of numbers can completely shift your perspective on success. Get ready to align your expectations with reality and set yourself up for genuine business growth__________________________________________Ep 194: Accelerating Your Conversion Rate Ep 244: Effective Launch Strategies for Creative EntrepreneursWant to stay connected to Michelle - Join the Sunday Morning Brew Crew! The Sunday Morning Brew is your private invitation to actionable insights that simplify your business, spark new ideas, and help you scale—without the burnout.Connect with Michelle on Facebook or Linkedin
Join the Focused Visionary Accelerator today (FVA)! FVA is your go to program if you are a business owner ready to scale to the next level. You will receive expert guidance, personalized coaching, a supportive community and live masterclasses!________________________________________Does it drive you crazy when businesses pass their credit card fees onto you? Do you feel turned off and hesitant to engage with them again? If you've been grappling with how to handle credit card fees in your own business, today's episode is the solution you've been searching for. We're breaking down exactly why you should stop passing these fees to your clients, and how a simple price adjustment can keep your customers happy while benefiting your bottom line. It's all about smart business practices that look professional and don't alienate your clients. _________________________________________Want to stay connected to Michelle - Join the Sunday Morning Brew Crew! The Sunday Morning Brew is your private invitation to actionable insights that simplify your business, spark new ideas, and help you scale—without the burnout.Connect with Michelle on Facebook or Linkedin
Join the Focused Visionary Accelerator today (FVA)! FVA is your go to program if you are a business owner ready to scale to the next level. You will receive expert guidance, personalized coaching, a supportive community and live masterclasses!--------------------------------------------------------------Gone are the days of sitting back and waiting for clients to roll in; taking proactive steps in lead generation is now crucial for success. As we approach 2025, it's essential to recognize that a passive approach to business will only hinder your growth. This episode emphasizes the importance of taking action and being strategic in your marketing efforts. From leveraging referral partners to engaging in coffee chats, the key is to stay top of mind and actively connect with potential clients. Tune in for some tough love and practical tips that will ignite your motivation to seek out new opportunities and build meaningful relationships in your business.__________________________________________________Related Episodes: Ep. 214: Relationship and Attraction Marketing for Lead Generation and ConversionEp. 229: Nurturing vs. Follow-Up: Key Differences for Effective Lead Generation___________________________________________________Want to stay connected to Michelle - Join the Sunday Morning Brew Crew! The Sunday Morning Brew is your private invitation to actionable insights that simplify your business, spark new ideas, and help you scale—without the burnout.Connect with Michelle on Facebook or Linkedin
Join the Focused Visionary Accelerator today (FVA)! FVA is your go to program if you are a business owner ready to scale to the next level. You will receive expert guidance, personalized coaching, a supportive community and live masterclasses!___________________________________________________Tired of setting those big, hairy, audacious goals that never seem to stick? I'm breaking down why traditional BHAG goal-setting often fails and introducing you to a more focused, data-driven approach using what I call the North Star method. Learn how to set goals that actually guide your decisions, keep you aligned with what matters, and help you achieve real results in your business – without the overwhelm or guilt that typically comes with traditional goal-setting.This episode ties directly into what we teach in the Focus Visionary Accelerator program. If you love what you hear and want to dive deeper, the doors are always open!_________________________________________________________Related Episodes: 219: Striking the balance between stretch and attainable goals208: Accountability - Why it works or doesn't work to help you achieve your goals__________________________________________________________Want to stay connected to Michelle - Join the Sunday Morning Brew Crew! The Sunday Morning Brew is your private invitation to actionable insights that simplify your business, spark new ideas, and help you scale—without the burnout.Connect with Michelle on Facebook or Linkedin
„Wir sind eine Behörde – und agieren doch wie ein Startup! Netzwerken statt Verwaltungssilos.“ In dieser Episode beleuchten Judith Ehrlacher von der Forstlichen Versuchs- und Forschungsanstalt Baden-Württemberg (FVA) und unser Experte Stefan Bald, wie modernes Wildtiermanagement im Rahmen staatlicher Strukturen funktioniert – oder besser gesagt: transformiert wird. Denn das Wildtiermanagement ist in Baden-Württemberg nicht einfach nur Verwaltung; es ist ein kreativer, agiler Ansatz, bei dem Menschen, Interessen und pragmatische Lösungen im Fokus stehen. Judith bringt auf den Punkt, was sie tagtäglich antreibt: „Es geht nicht darum, Wildtiere zu managen, sondern die Menschen, die mit ihnen zu tun haben – von Jägern über Förster bis hin zu Naturschützern und Tourismusplanern.“ Mit langjähriger Erfahrung im Bereich Wildtierforschung und einem engen Austausch mit verschiedenen Interessensgruppen zeigt Judith, wie ihre Abteilung in Netzwerken arbeitet, die ein klassisches Behördensystem in seiner Flexibilität oft übertreffen. Das Ziel? Tragfähige und nachhaltige Lösungen für alle Beteiligten. Ein Herzstück dieser Netzwerkarbeit ist das innovative Wildtierbeauftragten-System, das in den letzten Jahren sogar gesetzlich verankert wurde. Die Wildtierbeauftragten sind Ansprechpartner vor Ort und haben ihre eigenen, lokal verwurzelten Netzwerke, die die reibungslose Kommunikation und das schnelle Handeln im Umgang mit Wildtieren sicherstellen. „Wir haben gelernt, wie man innerhalb eines komplexen Systems kreative Lösungen entwickelt, indem man eng mit der Praxis zusammenarbeitet,“ erzählt Judith. Eine Behörde, die sich agil und flexibel den Herausforderungen einer sich ständig wandelnden Umwelt anpasst – wie das genau aussieht und welche Lehren auch andere Institutionen daraus ziehen können, erfahrt ihr in dieser inspirierenden Folge!
Peer support services provided by FVA grantees come in various forms, including a course called Marriage Management which is designed to help military and veteran couples reconnect and develop better relationships. In this episode, we spoke with co-founders Bob and Barbara Zielinski about their mission to guide couples in understanding and learning from one another. Marriage Management TVC Grants Directory
1. Dans la tête d'un oiseau Chanter à tue-tête, voyager sur des milliers de kilomètres, construire des nids solides, les oiseaux ont des capacités dʹapprentissage et dʹadaptation qui leur ont permis dʹêtre présents sur tous les territoires. Cécile Guérin décrypte ce quʹil se passe dans la tête dʹun oiseau, avec Gérard Leboucher, éthologue et auteur du livre "Dans le tête dʹun oiseau" (humenSciences, 2024) pour comprendre ces comportements formidables. 2. La Suisse face à lʹémergence des drogues de synthèse Les nouveaux produits de synthèse (NPS), également connus sous le nom de "legal highs", sont des substances psychoactives qui imitent les effets des drogues illégales telles que l'ecstasy, la cocaïne et le LSD. Ces substances sont souvent plus puissantes et potentiellement plus dangereuses que leurs équivalents illégaux. Face à la complexité de détection de ces substances, des initiatives de prévention ont été mises en place dans les principales villes suisses. Des programmes permettent aux consommateurs de drogues de tester gratuitement leurs produits, garantissant l'anonymat et permettant une intervention préventive ciblée. Laurence Froidevaux en parle avec Daniele Zullino, chef du Service dʹaddictologie aux Hôpitaux universitaires de Genève (HUG), et Stephane Caduff, responsable du secteur prévention à la Fondation vaudoise contre lʹalcoolisme (FVA). 3. Mission Green Fjord: le voilier suisse "Forel" à la conquête du Groenland Deux mâts, une coque de 28 mètres en aluminium et un poids qui sʹélève à environ 120 tonnes, cʹest ce à quoi ressemble le voilier "Forel", premier voilier-laboratoire suisse destiné à lʹexploration glaciaire. Lancé par lʹassociation Forel Heritage, il part cet été étudier les effets du changement climatique sur les écosystèmes des fjords du Groenland lors de la mission Green Fjord 2024. Samuel Jaccard, professeur à lʹInstitut des sciences de la terre de lʹUniversité de Lausanne (UNIL), fait partie de lʹéquipage. Il nous explique sa mission. Un sujet de Bastien Confino.
Brady Koester threw six shutout innings as the Kimberly Papermakers shut out Oshkosh North 9-0 Tuesday afternoon at North. With the win, Kimberly is now 15-2 in FVA play and 20-3 overall. Tony Giordana had the call.
Ein englisches Landbrot nach einem Rezept von Virginia Woolf – da fühlen sich Jan und Katharina der Autorin gleich viel näher. Vielleicht hätte eine passende literarische Vorspeise auch der Lektüre des aktuellen Bestsellers gut getan, denn dessen experimentelle Erzählweise überzeugt die Hosts nicht so ganz. Zu Gast ist der Verlagsvertreter Jochen Thomas-Schumann, der uns erstmal seinen wirklich wichtigen Job erklärt. Außerdem gibt es neue (beruhigende) Erkenntnisse bzgl. Teebeutel-Tee und es werden mal wieder diverse extra Bücher in die Folge geschummelt! Die Bücher der Folge: (00:02:41) Jans Ondaatje Rolls: “The Bloomsbury Cookbook” (Thames and Hudson) (00:07:16) Katja Kulin: “Geliebte Orlando” (DuMont) (00:09:24) Iris Wolff: „Lichtungen“ (Klett-Kotta) (00:18:42) Isabelle Autissier: „Acqua alta“, übersetzt von Kirsten Gleinig (mare) (00:25:54) Meri Valkama: „Deine Margot“, übersetzt von Angela Plöger (FVA) (00:50:16) Virginia Woolf: „Mrs. Dalloway“ (div.) Alle Infos zum Podcast: https://ndr.de/eatreadsleep Mail gern an: eatreadsleep@ndr.de Alle Lesekreise: https://ndr.de/eatreadsleep-lesekreise Unseren Newsletter gibt es hier: https://ndr.de/eatreadsleep-newsletter Podcast-Tipp: „Die Schule brennt“ https://www.ardaudiothek.de/sendung/die-schule-brennt-der-bildungspodcast-mit-bob-blume/12197843/ Rezept für Cottage Loaf http://www.ndr.de/kultur/buch/eatREADsleep-107-Cottage-Loaf-und-Rueckwaertslesen,eatreadsleep832.html eat.READ.sleep. ist der Bücherpodcast, der das Lesen feiert. Jan Ehlert, Daniel Kaiser und Katharina Mahrenholtz diskutieren über Bestseller, stellen aktuelle Romane vor und präsentieren die All Time Favorites der Community. Egal ob Krimis, Klassiker, Fantasy, Science Fiction, Kinder- und Jugendbücher, Urlaubsbücher, Gesellschafts- und Familienromane - hier hat jedes Buch seinen Platz. Und auch kulinarisch (literarische Vorspeise!) wird etwas geboten und beim Quiz am Ende können alle ihr Buch-Wissen testen und Fun Facts für den nächsten Smalltalk mitnehmen.
Ruth Williams ist ab kommenden Jahr die neue Geschäftsführerin des FVA und ist daher genau die richtige Gesprächspartnerin für unsere Fragen.
The Fund for Veterans' Assistance Big Check Tour is underway as Texas Veterans Commission travels across the state meeting our latest grantees. On this show we hear about services offered by current grantees and we have info on how to apply for FVA grants. The next grant application cycle is coming soon. FVA Grant Info is Here
Our Fund for Veterans' Assistance awards grants to nonprofits who in turn assist veterans. LiftFund is using its FVA grant to teach veteran entrepreners about showcasing their business in the digital world. It is not as scary as some might think, listen and learn. Find out more from LiftFund Here. Texas Veterans Commission Business Consultants work one on one with veterans and spouses who want to start or grow their own business. Make an appointment here.
For the first time in three years, the U.S. Navy Blue Angels have a new flight leader. Cmdr. Alexander Armatas officially took command of the Naval Flight Exhibition Team on November 13, 2022, at a ceremony at the National Naval Aviation Museum in Pensacola, Florida. He replaced Captain Brian Kesselring, who led the Team during its 75th anniversary and the transition to the F/A-18 Super Hornet. In this interview, Boss Armatas discusses his priorities and focus as the new commanding officer and flight leader for the Blue Angels, including getting to know each member of the Team, mastering the 45 minute air show demonstration, and ensuring his fitness and nutrition are optimized for high intensity flying and a rigorous schedule. With winter training in El Centro, California just weeks away, Boss Armatas also provides insight into the current flying syllabus and milestones the Team are focused on achieving, including flying the first Delta Formation for the 2023 Blue Angels. A native of Skaneateles, New York, Boss Armatas cites flyovers by a formation of F-16 Falcons from the New York National Guard and exposure to cargo operations at the Syracuse International Airport as early influences that sparked his passion for aviation. He also attended a number of airshows in London, Ontario, Canada during his informative years where he witnessed the Blue Angels perform for the first time. Graduating from the United States Naval Academy in 2002 with a degree in aerospace engineering, Boss Armatas earned his Wings of Gold in June of 2005 at Naval Air Station (NAS) Meridian, Mississippi. Initially assigned to NAS Lemoore, California, he served in a variety of different roles as part of Strike Fighter Squadron (VFA) 115, the “Eagles” and deployed three times on board the USS Ronald Reagan (CVN-76) in support of Operation Iraqi Freedom and Enduring Freedom. In 2009, Boss Armatas graduated from the world famous TOPGUN course at NAS Fallon, Nevada before joining VFA-122 the “Flying Eagles” where he was named the 2010 VFA-122 Instructor Pilot of the Year. Transferring to VFA-14 the “Tophatters”, Boss Armatas supported Operation Enduring Freedom in 2013 aboard the USS John C Stennis (CVN-74). Following this tour, he reported to NAS Oceana in Virginia Beach, Virginia to serve as the Department Head for FVA-143 the “Pukin' Dogs” and deployed aboard the USS Harry S Truman (CVN-75) in support of Operation Inherent Resolve. After serving as a Strike Fighter Placement Officer for the Navy Personnel Command (NPC) in Millington, Tennessee in 2017, Boss Armatas reported to VFA-105 the “Gunslingers” where he served as both Executive Officer and Commanding Officer during his tenure and deployed twice aboard the USS Dwight D Eisenhower (CVN-69) in support of Operation Freedom's Sentinel. With the encouragement of former Blue Angels pilot, John Hiltz, Boss Armatas submitted his application for the Blue Angels after accumulating more that 4,100 flight hours and 911 carrier-arrested landing. He was announced as the Commanding Officer of the Blue Angels in April of 2022 and officially joined the team in August. 2023 Blue Angels Team1. CDR Alexander Armatas2. LCDR Chris Kapuschansky3. LT Amanda Lee4. LT Scott Goossens5. LCDR Julius Bratton6. LCDR Griffin Stangel7. LCDR Thomas Zimmerman8. LCDR Brian VaughtXO CRD Jon FayM1 CAPT Jackson Streiff, USMCM2 MAJ Joshua Soltan, USMCM3 CAPT Samuel Petko, USMCMO LT Henry CedenoAssistant MO LCDR Gregory JonesFlight Surgeon LT Philippe WarrenSO LT Paul KrugerSupport the show
It's time for nonprofits and local government agencies to put those grant writing skills to good use. Texas Veterans Commission is now taking applications for next year's Fund for Veterans' Assistance Grants. Applications must be submitted by Dec 5, 2022. Listen in as one of our grantees, VETRIDE talks about their grant and how it helps, get some inspiration for your nonprofit, then go the website and get started applying for an FVA grant! https://www.tvc.texas.gov/grants/apply/
LiteraturPur #10: Corinna T. Sievers schreibt gern über Sex, explizit und direkt. Bisher ging es in ihren Romanen vor allem um die weibliche Lust, die sie als stark, divers und radikal beschreibt. Sie erzählte von Frauen, die ihre Lust ungehemmt ausleben, sich nehmen, was sie wollen. Im neusten Roman "Propofol" wechselt die Autorin die Perspektive und versetzt sich in den Kopf eines sexbesessenen Arztes, der Mühe hat alt zu werden. Im Gespräch erzählt mir Corinna, was sie an diesem Perspektivenwechsel reizt und was sie selber für ein Verhältnis hat zum Alter und dem Verlust der Schönheit. Zudem sprechen wir über ihr Doppelleben als Zahnärztin und Schriftstellerin und wie die Reaktionen in ihrem Umfeld darauf sind. Und sie verrät, warum sie nur nachts schreibt.
Einige Bücherfans kennen sie noch aus dem Berliner Buchladen ocelot: Julia Rothenburg ist zu Gast im „Berliner Zimmer“ und spricht über ihre drei Romane aus der Frankfurter Verlagsanstalt: „Koslik ist krank“, „hell/dunkel“ und „Mond über Beton“. Aber viel wichtiger sind die Fragen: Wird Klaus endlich die Lügenspiel-Vorherrschaft seiner Co-Moderatorin Judith brechen können? Welches Geschenk hat sich das Podcaster-Duo diesmal ausgedacht? Und wer ist hier eigentlich wirklich aus Berlin oder nur aus dem Norden oder Süden der Republik zugereist? In jedem Fall danken wir unserer megatollen Producerin Branka Prlic.
Hoy hablamos de Ford Cosworth. Los motores Ford Cosworth han ganado 176 GG.PP. de Fórmula 1… Nadie se acerca a este récord ni de lejos. Pero en un momento dado Ford decidió poner a la venta modelos deportivos con tecnología de la F1… y nacieron dos mitos, el Sierra Cosworth y el Escort Cosworth. Detrás de la aventura de Cosworth hay uno de esos grandes nombres. No, no me refiero a Ford ni a los fundadores, Mike Costin y Keith Duckworth sino a otro, para mi, aún más grande: Colin Chapman. Mike y Keith eran buenos en lo suyo y en 1958 fundaron en Londres la empresa Cosworth, nombre que proviene de la unión de sus dos apellidos. Partiendo del motor Ford Kent hicieron con gran éxito motores para monoplazas y para el Lotus Cortina. Y es en 1966 cuando Chapman convence a Ford de que apoye a Cosworth con 100.000 libras esterlinas para hacer un motor de F1. Cosworth unió dos motores FVA de 4 cilindros y 16 válvulas y creo el Cosworth DFV, “Double Four Valves”. Mercedes, BMW… y Ford. En 1982 Mercedes lanza una berlina deportiva: El Mercedes 190 2.3 16v. ¿Y sabéis quién les ayuda a utilizar en ese motor la tecnología de las 16 válvulas? Pues Cosworth… En Alemania se filtra que BMW va a lanzar un coche muy especial, un rival para el Mercedes y con tecnología multiválvulas… y en 1986 llega el primer M3. Y Ford no quiere quedarse atrás. Pero hace un coche valiente por varios motivos: Primero, le mete un turbo, cosa que ni BMW ni Ford habían hecho. Segundo, le ponen un alerón que deja en evidencia a los “aleroncitos” del 2.3 16 V y del M3. Gustará o no, pero es su seña de identidad. ¿Menos refinado? BMW y Mercedes lanzan estos modelos pensando en la competición, en el público muy deportivo, pero sin perder de vista, sobre todo Mercedes, a su público tradicional que busca un coche de mucha calidad y comodidad por muy deportivo que sea… Para ser justo: El Sierra Cosworth no es que fuera menos refinado en algunas cosas, como por ejemplo su interior, es que realmente era un coche mucho más radical. La potencia era similar a sus rivales, pero con más carácter, gracias entre otras cosas al Turbo. Segunda generación, ¿decepción? En 1988 para muchos aficionados sucede una hecatombe: El Sierra Cosworth gana un tercer volumen, dos puertas laterales y… pierde el alerón posterior. Y en efecto, no era lo mismo, ¡era mucho mejor! ¿Por qué? Porque con ese cambio de carrocería cambiaban muchas cosas. Por ejemplo, en la suspensión delantera había muchas mejoras que parecen de detalle, pero que hacen de este Sierra Cosworth un coche mucho más “redondo” que el primero. Además del reglaje de avance de pivote, de un estabilizadora más gruesa que pasa de 14 a 16 mm de diámetro y de unos nuevos amortiguadores de gas, el coche gana 10 mm de recorrido delante. Detrás la suspensión se endurece. Además, el cambio Borg-Warner es claramente mejor que el anterior, con un tacto casi de carreras. La presentación de este coche fue en Sicilia y el coche me enamoró… MKIII, más eficaz, menos divertido. En 1991 el Sierra Cosworth gana 16 CV y la tracción delantera. Con 220 caballos y tracción total, es un arma muy a tener en cuenta en los rallyes. Pero en carretera me gustó mucho menos. Eso sí: Este es el Sierra Cosworth más apto para todos los públicos que cualquier otro. Y no perdía carácter, pues aún con tracción total, el reparto de par era de más de un 60 por ciento en el tren posterior… pero era más eficaz y más seguro. El Sierra disfrazado de Escort. Siento ser aguafiestas, pero el Escort Cosworth no es un Escort. Lo cierto es que el coche era el más eficaz Ford Cosworth nunca construido y uno de los pocos coches de su época capaz de rodar en circuito con solvencia. Tenía mejoras importantes respecto al Sierra, pero para mí, en su momento, destaqué tres: Mayor agilidad gracias a su menor peso y mejores suspensiones; una notable mejora gracias a unas ruedas más adecuadas unas 225/45 16 que hoy serían las de un utilitario, pero que en su momento eran una joya; y unos frenos de 178 mm delante, ventilados, que eran una maravilla. ¡Hay que mojarse! Mi favorito es el Sierra Cosworth MKII. ¿Por qué? No porque tenga para mí el bastidor más equilibrado ni por tener el mejor cambio de todos ni por ser probablemente el Ford Cosworth menos cotizado… es por todo eso y porque siempre he pensado que es un coche que solo valoran en su justa medida los que saben de coches… como sois vosotros…
Julmar Grace Locsin is the Owner & CEO of FVA Business Consultancy Corporation. FVA offers online job courses to freelancers, virtual assistance services to brands and businesses, and franchising opportunities. Its very mission is Equipping Freelancers; Empowering Marketers, and Enabling Businesses through its Academy, Services, and Franchising. It is offering at least 30 plus courses in their FVA Academy, including at least 15 Franchising courses having territories all over the Philippines, the United States, Japan, Italy, the Kingdom of Saudi Arabia, Vietnam, and the United Arab Emirates. It has trained more than 20,000 freelancers and has been providing services to thousands of its customers over the past 4 years and endeavors, and targeting to train 1 million freelancers in the next 10 years. Julmar Grace Locsin is also known as a kingdom entrepreneur, freelancing thought leader, a woman in a mission, a resource speaker, and a writer. She recently introduced Surge Digital Agency, an FVA Business Consultancy Corporation company. It is the world's first one-stop freelancing marketplace providing online courses, online services, and freelancing solutions. What You'll Learn 1. Why she started FVA Business Consultancy Corporation. and how it changed her life and the community of virtual assistants, freelancers, and franchise owners. 2. What makes FVA a unique business that offers online job courses to freelancers, virtual assistance services to brands and businesses, and franchising opportunities? 3. How she managed her time as a mom to twin boys, Owner & CEO of FVA, and as a student in graduate school? 4. The challenges she encountered and overcame in the early days of FVA to registering it as a corporation and finding the right coaches and trainers. 5. Tips in building a profitable online education business like FVA and effectively managing the staff, students, and alumni, coaches, and trainers. Check out FVA's social media accounts and get to know more about the community. FACEBOOK – https://web.facebook.com/FVAConsultancy/ (https://web.facebook.com/FVAConsultancy/) INSTAGRAM – https://www.instagram.com/fvaconsultancy (https://www.instagram.com/fvaconsultancy) LINKEDIN -https://www.linkedin.com/in/julmargrace/ ( https://www.linkedin.com/in/julmargrace/) YOUTUBE – https://www.youtube.com/channel/UClEIL-u2Fl-mrae7ND7Vnow (https://www.youtube.com/channel/UClEIL-u2Fl-mrae7ND7Vnow) WEBSITES: https://www.fvaconsultancy.com/ (https://www.fvaconsultancy.com/ )| https://surgedigital.agency/ (https://surgedigital.agency/) HOW TO GET INVOLVED Join the Queen's only Tribe Facebook Group: High Value and Financially Independent Women Network Website: melissaprofeta.com Facebook Page: Melissa Profeta Get to know Melissa Profeta at https://www.thisismelp.com/ Enjoyed the Podcast? Be sure to subscribe and leave a review on iTunes and Spotify. We love to hear your feedback and we'd love for you to help us spread the word!
Kimberly defeated Hortonville 86-73 on the road in a FVA contest. B.J. DeGroot on the call!
#fuckoff 2020 oder gab es doch ein paar gute Seiten in diesem Jahr? Wir haben in unsere Leselisten geschaut und 60 Bücher herausgesucht, über die wir nochmal reden wollten: Edem Awumey (Ü:Stefan Weidle): Nächtliche Erklärungen, Weidle Verlag Robert Seethaler: Der letzte Satz, Hanser Berlin Enno Stahl: DiskursDisko, Verbrecher Verlag Iris Wolff: Die Unschärfe der Welt, Klett Cotta Christian Schulteisz: Wense, Berenberg Helena Adler: Die Infantin trägt den Scheitel links, Jung und Jung Gord Hill (Ü: Alexander Lippmann): Antifa, Bahoe Miriam Kühsel-Hussaini: Tschudi, Rowohlt Kaska Bryla: Roter Affe, Residenz Verlag Monika Helfer: Die Bagage, Hanser Stephan Roiss: Triceratops, Kremayr & Scheriau James Baldwin (Ü: Miriam Mandelkow): Giovannis Zimmer, DTV Max Czollek: Gegenwartsbewältigung, Hanser Anna Prizkau: Fast ein neues Leben, Friedenauer Presse Verena Kessler: Die Gespenster von Demmin, Hanser Berlin Laura Lichtblau: Schwarzpulver, C.H. Beck Jürgen Bauer: Portrait, Septime Verlag Rafael Horzon: Das neue Buch, Suhrkamp Anna Hope (Ü: Eva Bonné): Was wir sind, Hanser Dilek Mayatürk (Ü: Achim Wagner): Brache, Hanser Berlin Cemile Sahin: Alle Hunde sterben, Aufbau Deborah Levy (Ü: Reinhild Böhnke): Der Mann, der zu viel sah, Kampa Charlotte McConaghy (Tanja Handels): Zugvögel, Fischer Sebastian Stuerz: Das eiserne Herz des Charly Berg, btb Deniz Ohde: Streulicht, Suhrkamp Levin Westermann: Bezüglich der Schatten, Matthes und Seitz Berlin Oliwia Hälterlein und Aisha Franz: Das Jungfernhäutchen gibt es nicht, Maro Jana Steenfatt: Die Überflüssigkeit der Dinge, Hoffmann und Campe Anaïs Barbeau-Lavalette (Ü: Anabelle Assaf): So nah den glücklichen Stunden, Eichborn Roberta Tatafiore (Ü: Andreas Rostek): Einen Tod entwerfen, edition.fototapeta Sophie Calle (Ü: Sabine Erbrich): Das Adressbuch, Suhrkamp Michel Houellebecq (Ü: Stephan Kleiner): Ein bisschen schlechter, Dumont Bov Bjerg: Serpentinen, Ullstein Glennon Doyle (Ü: Sabine Längsfeld): Ungezähmt“ Rowohlt Knut Ødegård (Ü: Åse Birkenheier): Die Zeit ist gekommen, Elif Linus Giese: Ich bin Linus, Rowohlt Olga Tokarczuk (Ü: Doreen Daume): Gesang der Fledermäuse, Kampa Annie Ernaux (Ü: Sonja Finck): Die Scham, Suhrkamp Ilona Hartmann: Land in Sicht, Blumenbar Amanda Lasker-Berlin: Elijas Lied, FVA @wirmuesstenmalreden: Dear Discrimination, Mikrotext Karosh Taha: Im Bauch der Königin, Dumont Mikael Vogel: Tier, Verlagshaus Berlin Valerie Fritsch: Herzklappen von Johnson & Johnson, Suhrkamp Christina Maria Landerl: Alles von mir“ Müry Salzmann Stephan Roiss: Triceratops. Kremayr & Scheriau Nicolas Mathieu (Ü: Lena Müller und André Hansen): Rose Royal, Hanser Berlin Eliot Weinberger (Ü: Beatrice Faßbender, Eike Schönfeld, Peter Torberg): Neulich in Amerika, Berenberg Ágnes Heller (Dagmar Engel und Andreas Rostek): Orbanismus, edition.fototapeta Paula Barbosa und Dominik Bollow: Yuri und Vincent“ Round not Square Ben Lerner (Ü: Nikolaus Stingl): Topeka Schule, Suhrkamp Anaïs Meier: Über Berge, Menschen und insbesondere Bergschnecken, Mikrotext Jasmin Schreiber: Marianengraben, Eichborn Ronya Othmann: Die Sommer, Hanser Ivan Krastev (Ü: Karin Schuler) Ist heute schon morgen, Ullstein Anne Weber: Annette ein Hemdinnenepos, Matthes und Seitz Berlin Szczepan Twardoch (Ü: Olaf Kühl): Das schwarze Königreich, Rowohlt Christine Wunnicke: Die Dame mit der bemalten Hand, Berenberg
FDA 批准新型的核输出蛋白抑制剂用于治疗多发性骨髓瘤和弥漫大B细胞淋巴瘤LANCET 利妥昔单抗和短期强化化疗治疗成人Burkitt淋巴瘤Blood DIC时常出现的新型的凝血机制塞利尼索（selinexor）塞利尼索（selinexor）一种口服选择性核输出蛋白抑制剂，2019年被FDA批准上市用于治疗复发或难治性多发性骨髓瘤；2020年7月，适应症扩展到弥漫大B细胞淋巴瘤。《口服塞利尼索-地塞米松治疗三重难治性多发性骨髓瘤》 New England Journal of Medicine，2019年8月 (1)研究旨在评价塞利尼索对三重难治性多发性骨髓瘤的疗效和安全性。纳入122名、中位年龄65岁、至少一种蛋白酶体抑制剂、一种免疫调节剂和达雷木单抗耐药的、多发性骨髓瘤患者。给予每周两次口服塞利尼索80mg+地塞米松20mg治疗。26%的患者出现部分或更好的缓解，2名患者完全缓解；39%的患者轻微缓解或有所好转。中位缓解时间为4.4个月，中位无进展生存期为3.7个月，中位总生存期为8.6个月。血小板减少是常见的严重不良反应。结论：塞利尼索-地塞米松使现有治疗方法难以治愈的骨髓瘤患者延长了生存期。《SADAL研究：塞利尼索（selinexor） 在复发或难治性弥漫性大B细胞淋巴瘤患者中的应用》Lancet Haematology，2020年7月 (2)SADAL研究的目的是评估单药塞利尼索对复发或难治性弥漫大B淋巴瘤患者的疗效这项多中心、跨国、开放标签的2b期研究，纳入已经接受了2 - 5种治疗、自体干细胞移植后或不适合进行自体干细胞移植的、复发难治性弥漫大B细胞淋巴瘤患者共267人，随机接受塞利尼索60mg和塞利尼索100mg治疗，研究中期100mg剂量被终止。塞利尼索的总有效率为28%，12%的患者完全缓解，17%的患者部分缓解。最常见的3-4级不良事件是血小板减少、中性粒细胞减少、贫血等。最常见的严重不良事件是发热、肺炎和脓毒症。结论：塞利尼索单药治疗复发或难治性弥漫大B患者有一定的疗效，且不良事件可控制的。弥漫性大B细胞淋巴瘤弥漫性大B细胞淋巴瘤（DLBCL）是最常见的非霍奇金淋巴瘤，占25%。最常见的症状为颈部或腹部淋巴结肿大，约30%的患者出现全身性症状（发热、体重减轻、盗汗）。骨髓受累和结外髓外病变的发生率在30%和40%。弥漫大B细胞淋巴瘤的肿瘤细胞通常广泛表达B细胞抗原（CD19、CD20、CD22和CD79a）。《XPO1的表达会恶化不利的弥漫大B细胞的预后，而在没有p53突变体的情况下，塞利尼索可以有效地靶向该细胞》Journal of Hematology Oncology，2020年11月 (3)XPO1抑制剂塞利尼索（selinexor）最近被批准用于复发/难治性的弥漫大B细胞淋巴瘤，研究的目的是评价XPO1对患者的预后影响以及高危患者的合理联合治疗方案。来自厦门大学医学院的研究人员发现XPO1高表达的544例患者，均出现显著的预后不良的情况，尤其是在BCL2过表达的患者中。通过对30个、具有不同分子和遗传背景的弥漫大B细胞淋巴瘤的、细胞株进行研究后发现，塞利尼索具有很强的细胞毒性，特别是在BCL2重排、或MYC/BCL2双重打击的、高级别B细胞淋巴瘤（HGBCL-DH）中。然而，p53基因突变显著降低了塞利尼索在整个细胞系、以及BCL2重排、或MYC/BCL2双重打击的、高级别B细胞淋巴瘤亚群中的细胞毒性。塞利尼索联合BET抑制剂INCB057643对MYC/BCL2双重打击的、高级别B细胞淋巴瘤的治疗效果显著增强，克服了p53基因突变的耐药性。结论：XPO1降低了BCL2过表达和双重打击等预后不良因素的、弥漫大B细胞淋巴瘤患者的生存，这与塞利尼索在这两个细胞系中显示出的更好的疗效是一致的。在MYC/BCL2双重打击的、高级别B细胞淋巴瘤亚群中，联合使用INCB057643处理，可以克服p53基因突变导致的塞利尼索耐药的情况。《弥漫性大B细胞淋巴瘤的国际预后指标：IPI、R-IPI和NCCN-IPI的比较》Blood，2020年6月 (4)弥漫大B细胞淋巴瘤的患者生存率存在很大的异质性。目前临床上常用的预后评分系统包括：国际预后指数（IPI）、修订的IPI（R-IPI）和国家综合癌症网络IPI（NCCN-IPI）。这三种评分系统纳入一些简单临床参数（年龄、乳酸脱氢酶、受累个数/部位、分期、表现状态）。研究人员近20年来，接受利妥昔单抗联合环磷酰胺、阿霉素、长春新碱和强的松治疗的2124例患者的数据用于评估哪个评分系统能最准确的预测生存率。使用IPI、R-IPI和NCCN-IPI的5年生存率估计分别为54%至88%、61%至93%和49%至92%；三组评分的一致性指数分别为0.626、0.59和0.632。NCCN-IPI在高风险、低风险和生存期评价方面都表现更高；而且NCCN-IPI风险类别与生存期显著相关(P≤.01)。结论：NCCN-IPI的预测准确性较高，NCCN-IPI低风险的患者的生存结果良好，但如果能将肿瘤的分子特征和微环境特征整合到NCCN-IPI或IPI中，可能将提高其准确性。弥漫性大B细胞淋巴瘤的治疗初始标准治疗是联合化疗（如CHOP方案，环磷酰胺、多柔比星、长春新碱和泼尼松）+抗CD20单抗（利妥昔单抗），即R-CHOP方案。复发难治性弥漫大B细胞淋巴瘤首选自体干细胞移植。治疗进展：2017年，FDA批准Axicabtagene ciloleucel（商品名Yescarta，一种自体抗CD19嵌合抗原受体CAR-T细胞疗法）治疗复发难治性弥漫大B细胞淋巴瘤。《回顾性研究：R-CHOP方案治疗原发性纵隔大B细胞淋巴瘤》Blood，2020年6月 (5)原发性纵隔大B细胞淋巴瘤的治愈率随着利妥昔单抗的结合而提高；然而，放射治疗的作用仍不明确。2005年之前，通常建议患者接受R-CHOP方案放疗；2005年之后，只有治疗结束后PET扫描呈阳性的人才接受放疗。文章回顾性的分析了共159例患者，总体的5年生存期为89%，在不同的治疗时期相似，总体来说只有10%是难治性的。2005年后，共有113例患者进行了PET扫描，其中63%阴性，37%阳性，5年生存率为97%对88%。对于PET扫描评分较高的患者，预后也较差。结论：经R-CHOP治疗的纵隔弥漫大B淋巴瘤患者的结果是良好的，使用PET评估决定是否放疗减少了不必要的放疗。《HOVON-84研究：利妥昔单抗联合早期利妥昔单抗强化治疗弥漫性大b细胞淋巴瘤的3期临床研究》Journal of Clinical Oncology，2020年10月(6)该研究的目的是评估了R-CHOP方案的、前4个周期早期、强化利妥昔单抗治疗与标准R-CHOP方案比相比是否能改善预后。研究纳入574例、弥漫大B细胞淋巴瘤的患者，给予6个或8个周期的R-CHOP-14方案治疗，随机早期强化利妥昔单抗治疗（RR-CHOP-14方案）或不强化治疗（R-CHOP-14）。R-CHOP-14组和RR-CHOP-14组的、诱导期完全缓解率分别为89%和86%。中位随访92个月后，R-CHOP-14组和RR-CHOP-14组的、3年无进展生存率分别为74%和71%（P = 0. 15），两组总生存率分别为81%和76%（P=0.09）。在RR-CHOP-14组中，年龄在66岁至80岁的患者在前4个周期中经历了明显更多的不良事件，特别是中性粒细胞减少和感染。结论：RR-CHOP-14（在R-CHOP-14基础上早期强化使用利妥昔单抗）不能改善未经治疗的弥漫大B细胞淋巴瘤患者的疗效。Burkitt淋巴瘤Burkitt淋巴瘤是一种高度侵袭性的B细胞肿瘤，目前识别出3种不同的临床形式：地方性Burkitt淋巴瘤、散发性Burkitt淋巴瘤和免疫缺陷相关性Burkitt淋巴瘤。虽然流行病学、临床表现和遗传学特征有所不同，但是组织学上相同，并具有相似的临床行为，因此通常采用相似的方法治疗。对于大多数Burkitt淋巴瘤的成人患者，通常建议选择强化短程联合化疗，或者急性淋巴细胞白血病样的诱导+巩固+维持治疗，无法耐受的患者使用剂量调整的EPOCH化疗方案（依托泊苷、长春新碱、多柔比星、泼尼松、环磷酰胺）。近年来的一个的热点是在化疗基础上加用利妥昔单抗（抗CD20单抗）。《随机对照研究：使用风险适应性的、剂量调整的DA-EPOCH-R方案治疗Burkitt淋巴瘤》Journal of Clinical Oncology，2020年8月(7)研究的目的是评价，经剂量调整的（依托泊苷、长春新碱、多柔比星、泼尼松、环磷酰胺）联合利妥昔单抗（DA-EPOCH-R方案）治疗Burkitt淋巴瘤的疗效。研究纳入113名未接受过治疗的Burkitt淋巴瘤患者，中位年龄49岁，25%HIV阳性，低风险患者接受了无中枢神经系统预防的、3个周期的治疗；高风险患者接受了6个周期的治疗、以及鞘内治疗。中位随访58.7个月，低危患者无进展生存率和总生存率分别为84.5%和87.0%；高危患者无进展生存率和总生存率分别为82.1%和100%和。治疗对不同年龄组、HIV阳性和各风险组都同样有效。疾病累及脑脊液的、高危患者中，药物毒性相关的死亡或治疗失败的风险最大。5例治疗相关死亡发生在治疗期间，发热性中性粒细胞减少发生在16%的周期中，肿瘤溶解综合征是罕见的。结论：DA-EPOCH-R方案治疗对成人Burkitt淋巴瘤有效，且耐受良好，无论年龄或HIV状态如何。但疾病脑脊液的患者的治疗方案仍需商榷。《开放标签对照研究：利妥昔单抗和短期强化化疗治疗成人Burkitt淋巴瘤的3期临床研究》Lancet，2016年6月(8)这项随机、对照、开放标签的3期临床试验中，招募了45个中心的、>18岁的、新诊断的、HIV阴性的Burkitt淋巴瘤患者。分为B组（无骨髓或中枢神经系统受累）和C组（有骨髓或中枢神经系统受累）。治疗方案为利妥昔单抗+LMB方案化疗，以及单独LMB方案化疗。共纳入260例患者，中位随访38个月。利妥昔单抗组3年无事件生存率75%，显著优于单独化疗组；不良事件在两个治疗组之间没有差异，最常见的是感染和中性粒细胞减少。结论：在短期强化化疗方案中加入利妥昔单抗可以改善成人Burkitt淋巴瘤的无事件生存率。 《队列研究：美国30个癌症中心的、真实世界的、Burkitt淋巴瘤的治疗结果与进展》Blood，2020年7月(9)研究人员对2009年至2018年的、美国30个癌症中心的、未经治疗的Burtkitt淋巴瘤的成人患者进行了分析。研究人员分析了641例Burkitt淋巴瘤患者基线特征包括：中位年龄47岁；HIV阳性 占22%；23%的患者ECOG生活质量评分 2-4分；42%患者有>1个淋巴结外病灶；晚期78%；中枢神经系统受累19%；治疗相关死亡率为10%，最常见的原因是败血症、胃肠道出血、穿孔和呼吸衰竭。在45个月的中位随访中，3年的无进展生存率和总生存率分别为64%和70%，这与是否为HIV阳性无关。接受利妥昔单抗治疗的患者生存率更更高（3年无进展生存率为为67%比38%；总生存率为72%比44%），这与是否住院治疗无关。在学术中心治疗的患者和在社区中心治疗的患者的结果也有所改善（3年无进展生存率为67%比46%；总生存率72%比53%)。多变量模型中，预测生存率较短的因素包括：年龄≥40岁、ECOG生活质量评分2-4分、乳酸脱氢酶>3xULN和中枢神经系统受累；而且，以上因素越多，生存率越低生存率。结论：真实世界的分析中，成人Burkitt淋巴瘤的临床预后比临床研究的结果更温和。此外，疾病诊断时确定的预后相关的因素可以帮助评估真实的预后。新型的DIC中由组蛋白启动的替代凝血酶通路《基础研究：弥散性血管内凝血中，由细胞外组蛋白启动的替代凝血酶通路》Blood，2020年7月 (10)凝血酶的产生、活化对弥散性血管内凝血（DIC）的病理发展都至关重要。通常，凝血酶由凝血酶原复合物产生，包括活化的X因子（FXa）、活化的辅助V因子（FVa）和磷脂（钙离子存在的情况下清除凝血酶）。在危重症中，广泛的细胞损伤可释放组蛋白进入循环，增加凝血酶的生成，引起DIC，但其分子机制尚不清楚。在本研究中，来自利物浦大学的研究人员发现：在有组蛋白，但是没有活化的辅助V因子和磷脂的情况下，机体也能形成一种替代的凝血酶。组蛋白可以直接结合凝血酶原片段F1和F2，促进X因子裂解凝血酶原、释放凝血酶，而不需要磷脂参与。小鼠体内输注组蛋白可诱导产生DIC；但如果事先输注凝血酶原F1+F2片段，再输注组蛋白则显著降低DIC出现的可能性。在重症监护病房脓毒症患者中（n=144），DIC患者的循环组蛋白水平显著升高。这些数据均表明，组蛋白诱导的替代凝血酶可诱导血管内凝血，并揭示了凝血酶产生和DIC发展的新的分子机制。此外，在这个凝血机制中，组蛋白使X因子的需求显著减少，即使VIII因子和IX缺乏的小鼠中，也能形成血栓。结论：本研究揭示了一种具有治疗潜力的、新型的凝血机制，既可以激活全身凝血功能，又可以纠正凝血因子缺陷导致的凝血功能障碍。《COVID-19及其对血栓和抗凝的影响》Blood，2020年6月 (11)COVID-19引起的严重感染可能与凝血功能障碍有关，这在感染引起的弥散性血管内凝血功能障碍（DIC）患者中观察到的炎症变化很相似。肺是COVID-19的靶器官，患者急性肺损伤可发展为呼吸衰竭，也可发生多器官衰竭。COVID-19的初始凝血病变表现为D-二聚体和纤维蛋白/纤维蛋白原降解产物显著升高，而凝血酶原时间、部分凝血酶时间和血小板数量异常相对少见。故建议对患者进行凝血功能筛查，包括测定D-二聚体和纤维蛋白原水平。治疗上，应像对待任何危重病人一样管理，遵循对危重病人采用的血栓栓塞预防、和对脓毒症引起DIC的患者采用标准支持治疗。虽然D-二聚体、脓毒症生理学和消耗性凝血障碍是死亡的预测因子，但目前的数据不建议使用足量抗凝。尽管COVID-19相关的凝血功能障碍，但出血时间尚未见报道。如果确实发生出血，应遵循DIC和出血管理的标准指南。《回顾性观察队列研究：COVID-19患者出院后的血栓和出血时间》Blood，2020年8月 (12)COVID-19肺炎与血栓前状态相关，住院期间血栓事件发生率高；然而，出院后血栓形成的数据有限。研究人员对未接受抗凝治疗的COVID-19出院患者进行了回顾性观察队列研究。该队列包括163名患者，平均随访30天，平均住院时间为6天， 26%需要重症监护。出院后第30天血栓累积发生率（包括动脉和静脉事件）为2.5%；单纯静脉血栓栓塞发生率为0.6%；大出血发生率为0.7%，非大出血发生率为2.9%。因此，COVID-19患者出院后血栓形成率和出血率似乎相似，这强调需要更多的研究来提供全面的、出院后的血栓预防建议。参考文献1.Chari A, Vogl DT, Gavriatopoulou M, Nooka AK, Yee AJ, Huff CA, et al. Oral Selinexor-Dexamethasone for Triple-Class Refractory Multiple Myeloma. N Engl J Med. 2019;381(8):727-38.2.Kalakonda N, Maerevoet M, Cavallo F, Follows G, Goy A, Vermaat JSP, et al. Selinexor in patients with relapsed or refractory diffuse large B-cell lymphoma (SADAL): a single-arm, multinational, multicentre, open-label, phase 2 trial. Lancet Haematol. 2020;7(7):e511-e22.3.Deng M, Zhang M, Xu-Monette ZY, Pham LV, Tzankov A, Visco C, et al. XPO1 expression worsens the prognosis of unfavorable DLBCL that can be effectively targeted by selinexor in the absence of mutant p53. J Hematol Oncol. 2020;13(1):148.4.Ruppert AS, Dixon JG, Salles G, Wall A, Cunningham D, Poeschel V, et al. International prognostic indices in diffuse large B-cell lymphoma: a comparison of IPI, R-IPI, and NCCN-IPI. Blood. 2020;135(23):2041-8.5.Hayden A, Tonseth P, Lee DG, Villa D, Gerrie AS, Scott DW, et al. Outcome of Primary Mediastinal Large B-cell Lymphoma Using R-CHOP: Impact of a PET Adapted Approach. Blood. 2020.6.Lugtenburg PJ, de Nully Brown P, van der Holt B, D'Amore FA, Koene HR, de Jongh E, et al. Rituximab-CHOP With Early Rituximab Intensification for Diffuse Large B-Cell Lymphoma: A Randomized Phase III Trial of the HOVON and the Nordic Lymphoma Group (HOVON-84). J Clin Oncol. 2020;38(29):3377-87.7.Roschewski M, Dunleavy K, Abramson JS, Powell BL, Link BK, Patel P, et al. Multicenter Study of Risk-Adapted Therapy With Dose-Adjusted EPOCH-R in Adults With Untreated Burkitt Lymphoma. J Clin Oncol. 2020;38(22):2519-29.8.Ribrag V, Koscielny S, Bosq J, Leguay T, Casasnovas O, Fornecker LM, et al. Rituximab and dose-dense chemotherapy for adults with Burkitt's lymphoma: a randomised, controlled, open-label, phase 3 trial. Lancet. 2016;387(10036):2402-11.9.Evens AM, Danilov AV, Jagadeesh D, Sperling AL, Kim SH, Vaca RA, et al. Burkitt Lymphoma in the Modern Era: Real World Outcomes and Prognostication Across 30 US Cancer Centers. Blood. 2020.10.Abrams ST, Su D, Sahraoui Y, Lin Z, Cheng Z, Nesbitt K, et al. Assembly of alternative prothrombinase by extracellular histones initiate and disseminate intravascular coagulation. Blood. 2020.11.Connors JM, Levy JH. COVID-19 and its implications for thrombosis and anticoagulation. Blood. 2020;135(23):2033-40.12.Patell R, Bogue T, Koshy AG, Bindal P, Merrill M, Aird WC, et al. Post-discharge thrombosis and hemorrhage in patients with COVID-19. Blood. 2020.
Corta entrega de FVA, los juveniles no podrán jugar y pocos participaran en las categorías mayores, la liga busca que la patrocinen para cubrir gastos, un nuevo fútbol se aproxima en Guatemala.
IBF on Demand Episode 6 (19.5.20) Sponsored by Arkieva, your one plan S&OP software. Learn more about Arkieva's approach to demand planning here: https://bit.ly/demand-management-reso...Here I discuss Forecast Value Added (FVA) with special guest Sara Park, Vice President, Exec S&OP, Forecasting COE and Supply Chain Planning at The Coca-Cola Company. We discuss how to use FVA to determine which forecasting models, inputs, or activities are either adding value or are actually making it worse. This technique can be game-changer for your forecast accuracy.08:00 Collaborating with other functions to get the inputs that are either helping or hurting 12:15 Knowing which functions help or hurt forecast accuracy14:55 FVA at the item level16:00 Getting started with FVA17:28 FVA for mature organizations19:19 What's a good FVA percentage?22:50 Why FVA is better than MPE and MAPE26:54 5 best practices when using FVAUseful article on FVA: https://demand-planning.com/2018/02/1...Find out more about IBF at www.ibf.org and www.demand-planning.comFind out about Arkieva at www.arkieva.com
In „Revanche“ durchstreift Claire Beyer episodisch hundert Jahre einer Familiengeschichte. Im Mittelpunkt steht Tobias Ristow, der dritte von drei Söhnen eines erfolgreichen Unternehmers, der sich schwer tut im Leben: Beruf, Liebe, nichts will ihm so recht glücken.Rezension von Beate Tröger. FVAISBN 978362700268820 Euro
Zwei Tage vor Weihnachten darf man wieder an sich und seine Lektüre denken: Wir stellen Bücher vor, die man selbst lesen will in der (vielleicht) endlich wieder ruhigen Zeit - oder die sich für gute Vorsätze eignen: Johann Peter Hebel zum Beispiel - dessen berühmte Kalendergeschichten nur ein kleiner Teil seines Werks sind. Sämtliche Werke sind jetzt bei Wallstein erschienen. Frank Jakubzik hat einen schmalen Band mit fantsatischen Erzählungen aus dem Alltagsleben geschrieben. Hanns-Josef Ortheil geht einen ganzen Roman lang mit Hemingway durch Venedig und wir stellen "Herr Groll und die Donaupiraten" von Erwin Riess vor, genauso wie die Revanche von Claire Beyer. Und wir besuchen die Umweltaktivistin Phyllis Omido in Kenia. Frank Jakubzik: Gefühlte ZuversichtSuhrkamp VerlagISBN: 978-351812758214 EuroRezension von Loreen DalskiJohann Peter Hebel: Gesammelte WerkeWallstein VerlagISBN: 978-3-8353-3256-0 59 EuroRezension von Gerwig EpkesErwin Riess: Herr Groll und die Donaupiraten Otto Müller VerlagASIN: B07X2Q3DSY 320 Seiten23 EuroEmpfehlung von Gerwig EpkesPhyllis Omido: Mit der Wut einer MutterEuropa VerlagISBN: 978-395890280018 EuroRezension von Marion BarzenH.-J. Ortheil: Der von den Löwen träumteLuchterhand Verlag978-3630874395 22 EuroGesprächs-/Lesungsauszug aus dem Mainzer StaatstheaterClaire Beyer: RevancheFVAISBN 978362700268820 EuroRezension von Beate Tröger
STAN BOSTIC: NATIONAL DIRECTOR OF COMMUNICATIONS FOR RICK CASE AUTOMOTIVE GROUP A major part of my job responsibilities is to partner, patronize and assist those nonprofits who are supported by the organization which is dedicated to many nonprofits which assist children and families in need. I develop programs year round that are blended with sales initiatives to financially support nonprofits in our community so they can continue to achieve their mission. Many of these organizations are smaller than national organizations that do not have the deep resources to perform their services to the inner community children and families. Also, we have a program which is called Bikes for Kids which provides bicycles for children in the community that want on during the holiday season. We collect and distribute more than 10,000 cycles every year. PRESIDENTIAL COMMUNITY SERVICE AWARD Presented by President Obama in recognition for a career dedicated to the service to community and our Nation COMBINED JOINT TASK FORCE REGIONAL COMMAND KANDAHAR AFGANISTAN RECOGNITION In appreciation and support to veterans VETERANS ADVISORY BOARD MEMBER - CITY OF SUNRISE VETERANS COMMUNITY SERVICE LEADERSHIP AWARD FROM DAV POST 133 POMPANO BEACH FLORIDA 2017 DEVELOPED PARTNERSHIP WITH FLORIDA PANTHERS TO ESTABLISH THE HEROES AMONG US PROGRAM Program to acknowledge local former and active duty military who also serve our community above and beyond HONORARY BOARD MEMBER – CHIEF PETTY OFFICERS ASSOCIATION, CPOA MIAMI HONORARY BOARD MEMBER – FREEDOM VETERANS OF AMERICA 2011 TO PRESENT FVA is a nonprofit organization whose mission is to assist our former and active duty military and their families in transition with housing, employment, health, security, transportation, education, financial aid, legal representation and any other matter deserving of those who have served DIRECTOR FVAMA – FREDOM VETERANS OF AMERICA MOTORCYCLE ASSSOCIATION Former and active duty military who ride for the service and honor of others in the military, police and others who wear the sacred cloth of freedom HONOR FLIGHT OF SOUTH FLORIDA – FOUNDING MEMBER HFSF is a nonprofit organization whose mission is to raise funds in order to transport WWII Veterans to Washington DC, so they can see the monument dedicated to their Brothers who made the ultimate sacrifice. The program is designed to prioritize WWII and continue with veterans with wars thereafter FOUNDER – FREEDOM FLIGHT OF SOUTH FLORIDA, FFSF FFSF is a non-profit organization whose mission is to support those former and active duty military service personnel, first responders and their families for their service. Through donations and philanthropy, we take those who have served, free of charge, to Washington D.C, New Orleans or NYC so they can see the memorials that were built for their service and sacrifice to our Country. PRESIDENT – FREEDOM FLIGHT RIDERS MOTORCYCLE ASSOCIATION Made up of Military, First Responders and Patriot motorcycle riders who volunteer and host fundraising events, preside in private and public ceremonies in honor of Military and First Responders while representing the best of what our Country stands for, our Flag. PRESIDENT-PRESTIGE CLUB Prestige is a nonprofit organization whose mission is to assist children in need – we engage 28 other nonprofits to assist them with children who have been raped, abused, bullied, abandoned and those who are physically challenged, have terminal disease and need love and compassion WESTON FLORIDA CHAMBER OF COMMERCE – TRUSTEE MEMBER SUNRISE CHAMBER OF COMMERCE – MEMBER PLANTATION CHAMBER OF COMMERCE - MEMBER MASSACHUSETTS MARITIME ACADEMY ALUMNI ASSOCIATION HONORABLE DISCHARGE USN MASTERS OF BUSINESS NEW YORK INSTITUTE OF TECHNOLOGY COMMISSIONED USNR 1976-1991 GRADUATED MASSACHUSETTS MARITIME ACADEMY BS ME/ME VETERANS OF FOREIGN WARS VOLUNTEER AMERICAN LEGION VOLUNTEER DISABLED VETERANS VOLUNTEER As the Son of a 26 year retired Master Chief I learned the act of giving and assisting veterans by spending my nights and weekends, when my Father was home and with guardians when he was deployed, by going to hospitals, homes, rehabilitation centers and military bases to assist veterans and their families who were returning from Vietnam. Through the Academy and since I continued giving time to these organizations and finding ways through my profession to develop outreach programs that can make a difference to former and active duty military and their families. MARCH OF DIMES VOLUNTEER As the Son of a dedicated Mother who raised 5 children while her Husband served our nation she found time to reach out and dedicated herself and I through the March of Dimes which is a nonprofit organization that helps improve the health of mothers and their babies. I learned from her as the oldest of my siblings to care for other children as if they were my brothers and sisters and I continued making time throughout my life to care for mothers and children in need by volunteering in hospitals and developing outreach programs through established nonprofits whose mission is synergistic. Dear Patriot, I am proud to announce that Freedom Flight South Florida, FF-SF, has begun its operations in South Florida to honor the US Military and First Responders for their service. FF-SF and its Volunteer Corps will be convicted to a mission of bringing every US citizen who has served honorably in the US Military beginning with our most revered WWII men and women to those men and women who have and continue to protect and serve our nation as First Responders to the monuments and memorials built in honor for a day of ceremony and honor. For our Military we intend to provide free passage to Washington D.C., Virginia and other historical sites in the USA, as well as, abroad. Our First Responders will be honored in New York City, Washington D.C. and other US Cities. Both groups of Heroes will also have local and State events at which time they will be acknowledged for their service. FF-SF is also vigorously supporting the fundraising efforts on the passage of Senate House Bill H.R.1037, authorizing the creation of a national EMS memorial in Washington D.C. while supporting and creating synergy among other charitable organizations with a similar mission. FF-SF is an all-Volunteer organization whose Board is comprised of Citizen’s who have and exhibit the highest integrity, morals and values while sharing the FF-SF Mission. FF-SF will a raise the monies needed to fulfill its mission through donations, fundraisers, sponsorships and the sale of branded merchandise. FF-SF’s website is www.freedomflightsouthflorida.org where you can read and be updated with all activities. For all those who have supported me and my efforts to serve the Veterans in South Florida I thank you and look forward to and will appreciate your support of FF-SF and its mission in the future. Respectfully, Founder and CEO 954-560-7905 Cell stanbostic@ff-sf.org
The Papermakers claimed three victories last week. Tuesday (4/9) Kimberly defeated Neenah 10-1 and picked up their third FVA victory of the season improving their record to 4-1 overall. Then over the weekend, the Papermakers claimed victories over Olentangy Liberty (OH) 6-0, Mount Vernon Academy (OH) 9-0! This week, Kimberly slated to hit the road on Thursday (4/18) and square off with Appleton North.
The Papermakers claimed three victories last week. Tuesday (4/9) Kimberly defeated Neenah 10-1 and picked up their third FVA victory of the season improving their record to 4-1 overall. Then over the weekend, the Papermakers claimed victories over Olentangy Liberty (OH) 6-0, Mount Vernon Academy (OH) 9-0! This week, Kimberly slated to hit the road on Thursday (4/18) and square off with Appleton North.
Patriots with back-to-back shutout wins late last week. Thursday (4/4) Appleton East blanked Oshkosh North 4-0 to pick up their first Fox Valley Association win of the year. They followed that up with an 8-0 win on the road Friday (4/5) against Fox Valley Lutheran. Patriots pitcher Carson Cook tossed a no-hitter with 12 strikeouts in the win. Busy week for Appleton East as they have a stretch with three games in four days against FVA opponents.
Patriots with back-to-back shutout wins late last week. Thursday (4/4) Appleton East blanked Oshkosh North 4-0 to pick up their first Fox Valley Association win of the year. They followed that up with an 8-0 win on the road Friday (4/5) against Fox Valley Lutheran. Patriots pitcher Carson Cook tossed a no-hitter with 12 strikeouts in the win. Busy week for Appleton East as they have a stretch with three games in four days against FVA opponents.
Terrors finished off the 2018-19 regular season with an 80-76 road win at Oshkosh North last Thursday (2/21). The win ran their FVA record to 12-6 as Appleton West finished in a tie for third place in the Fox Valley Association with Neenah. The Terrors earned a #2 in their sectional and open up play on Thursday (2/28) at home against Chippewa Falls.
Terrors finished off the 2018-19 regular season with an 80-76 road win at Oshkosh North last Thursday (2/21). The win ran their FVA record to 12-6 as Appleton West finished in a tie for third place in the Fox Valley Association with Neenah. The Terrors earned a #2 in their sectional and open up play on Thursday (2/28) at home against Chippewa Falls.
Papa Murphy’s Pizza Presents the High School Team of the Week.The Kaukauna Ghosts picked up a 86-72 road victory last Friday night over Appleton West. The Ghosts improved to 7-2 overall and 5-2 in the FVA.Next up for Kaukauna, they head to Appleton East on Tuesday night, then travel to Appleton North on Friday night. The winning school receives a plaque from J & B Trophy, located at 104 East Wisconsin in Appleton. Congratulations to this week’s winner!
Papa Murphy’s Pizza Presents the High School Team of the Week.The Kaukauna Ghosts picked up a 86-72 road victory last Friday night over Appleton West. The Ghosts improved to 7-2 overall and 5-2 in the FVA.Next up for Kaukauna, they head to Appleton East on Tuesday night, then travel to Appleton North on Friday night. The winning school receives a plaque from J & B Trophy, located at 104 East Wisconsin in Appleton. Congratulations to this week’s winner!
205 - More Than Meets The Eye: The Fearsome Foursome of Ricardo, Brett, Rosie and Trent are are back to talk Kimberly/Neenah football, FVA boys soccer, how club/AAU hoops have ruined the HS game and give their thoughts on overrated toys on the eve of Ricardo taking his son to a special showing of Transformers:The Movie (1986)!
Rockets coming off a championship at the Joust Invite (Aug. 25th) opened up FVA play with a 3-0 sweep of Hortonville Thursday August 30th to improve to 11-1 on the year and 1-0 in conference play.
Rockets coming off a championship at the Joust Invite (Aug. 25th) opened up FVA play with a 3-0 sweep of Hortonville Thursday August 30th to improve to 11-1 on the year and 1-0 in conference play.
ESPECIAL: Festival Vida e Arte 2018O podcast da editora Dummar recebe para uma conversa os curadores da 3ª edição do Festival Vida e Arte. Regina Ribeiro, Émerson Maranhão e Cecília Eurídice falam sobre a programação do Festiva que acontece nos próximos dias 22, 23 e 24 de junho. Entre memórias das duas últimas edições, destacam as atividades e os convidados das palestras, dos debates, dos shows, dos lançamentos, das meditações dessa festa da cultura.Você pode comentar nesse post ou enviar suas sugestões e reclamações para o e-mail podcast@opovo.com.br, com "Folha de Rosto" no título, que podemos ler e responder na edição seguinte.Ficha TécnicaPodcast Folha de Rosto apresentado por Humberto Pinheiro.Disponível em outras plataformasAssine o podcast no iTunes (e avalia a gente): http://bit.ly/folhaderostorssRSS feed: http://bit.ly/fdrostorssfeedSegue a gente no Spotify: http://bit.ly/fdrostospotifySegue a gente no Deezer: http://bit.ly/fdrostodeezer
133 - District, WIAA and FVA chatter: The Three Amigos are back and talking WIAA regional meeting happenings, specifically the realignment issues. Ricardo wonders why Wisconsin just doesn't go to district play for everything. Brett's exhausted from having to do a lot of the NE Wisconsin Sports Awards stuff. We then talk about the FVA hoops all-star game and Jordan McCabe and Sydney Levy's quest to make sure the girls are featured as well. We also speculate on the UWSP football opening and a certain Kimberly coach who would be a good fit. We then wrap up with a short preview of the Roundtable show with Appleton North SB players Marissa Mullen and Sara Allison.
127 - WIAA state girls recap; boys state preview: The Three Amigos are back from an interesting weekend. We discuss Appleton North's straight-up whoopin' of Classic 8 teams Arrowhead and Mukwonago in winning its second D1 title. We touch on the Xavier upset to Valders and preview the WIAA state boys hoops tournament with Oshkosh North and Kaukauna expected to win titles. FVA rules people! We then give our top memories from the fall and winter livestreams and preview our upcoming Varsity Roundtable with Appleton North champion hoopsters Kari Brekke and Kalen Klitzke!
120 - Jam-uary week and urban/rural talk: The Three Amigos are back talking a lot of hoops. We start with Appleton North's win over Appleton West in girls hoops then move on to boys hoops with Kaukauna now the leader in the FVA. Then the big elephant in the room: the discussion on the rural/urban proposal for high school hoops that has Ricardo and Brett beside themselves. Let's just say Ricardo and Brett aren't fans of the idea of having the WIAA move up smaller private schools a division just to apease a small group of rural schools. We then talk about Seymour girls hoops and their appearance on the Varsity Roundtable later tonight as well as a preview of Jam-uary week on Saturday at the Border Battle.
116 - Merry New Year!: The Three Amigos are back talking area hoops! We discuss the Xavier boys scoring a whole bunch of points and maybe being better than last year's state champs. Who would win in a mythical game between the Hawks and Jordan McCabe's Kaukauna Ghosts? Also talk some girls hoops. Is Wrightstown the top team in the NEC? How about the FVA with Appleton North/Kimberly/Hortonville? Hey, Aaron Rodgers is the special guest for the HS sports award show in May and Brett's excited. Ricardo's a Bears fan so he's not. We also preview Wrightstown girls hoops on the Roundtable and we're all full of good cheer thinking about Christmas. Happy Holidays!!
Keun Lee (Seoul National University) XIV SOAS Industrial Development and Policy (IPD) Lecture There is an emerging call for a need to integrate the two approaches, GVC and IS (innovation systems), with the recent initiatives by Lundvall (Lundvall, 2015, 2016). The current study can also be considered as an attempt to seek a linkage between the two approaches or integrating the two. The integration of the two approaches is important since just joining the GVC does not guarantee upgrading, and an economy might be stuck in low value activities, without functional upgrading. This paper thus proposes the In-out-and In again hypothesis that while at the initial stage of growth more GVC is desirable for learning from outside, functional upgrading requires some effort or stage of seeking separation and independence from the existing foreign-dominated GVC, and that the latecomer firms and economies might have to seek again for an opening to integrate back into the GVC after building up their own local value chains. This paper has tried to verify this ‘N-shaped, In-Out-In again’ hypothesis first by looking into cases of ‘upgrading’ in Korea, Brazil, and India, and second by checking the national level data of the share of domestic value-added (DVA). It is shown that the trends of FVA in successful catching-up economies are consistent with this In-Out-In again pattern. The paper also confirms some correlations between the degree of local creation and diffusion of knowledge and the values of DVA. This illustrates the linkage between the innovation system variables (knowledge localization) to the GVC variable of the DVA (1-FVA). Keun Lee is the winner of the 2014 Schumpeter Prize for his monograph on Schumpeterian Analysis of Economic Catch-up (2013 Cambridge Univ. Press). He is now the President of the International Schumpeter Society, an editor of Research Policy, a council member of the World Economic Forum, and a member of the governing board of Globelics. He is a Professor of Economics at the Seoul National University. Speaker(s): Keun Lee (Seoul National University), Antonio Andreoni (SOAS) Event Date: 27 June 2017 Released by: SOAS Economics Podcast
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