Podcasts about risk factors

On episode #99 of the Infectious Disease Puscast, Daniel reviews the infectious disease literature for the weeks of 1/15/26 - 1/28/26. Host: Daniel Griffin and Sarah Dong Subscribe (free): Apple Podcasts, RSS, email Become a patron of Puscast! Links for this episode Viral Symptomatic and asymptomatic norovirus infections in early life; The PREVAIL Cohort, 2017-2020 (CID) Bacterial Xenodiagnosis to search for Borrelia burgdorferi after antibiotic treatment of Lyme disease: a prospective cohort study (CID) Diagnostic Yield of Repeat Blood Cultures and Risk Factors for Bloodstream Infection in Persistent Febrile Neutropenia (CID) Methodology Misrepresented: Correcting the Record on the ATS Community-acquired Pneumonia Guideline Process (CID) Pediatric Infectious Diseases Physicians' Preferences for Management of Clostridioides difficile Infection: An Emerging Infections Network Surve (Journal of the Pediatric Infectious Diseases Society) Antibiotic Therapy for Uncomplicated AcuteAppendicitis (JAMA) Fungal The Last of US Season 2 (YouTube) Persistence of Symptoms among Commercially Insured Patients with Coccidioidomycosis, United States, 2017–2023 (CDC: Emerging Infectious Diseases) Ophthalmologic evaluation and clinical outcome in candidemia: a seven-year retrospective multicenter cohort study (OFID) Parasitic Postinfectious Syndromes and Long-Term Sequelae after Giardia Infections (CDC: Emergining Infectious Diseases) Priced Out of Treatment: The Exorbitant Cost of Antiparasitic Drugs in the United States (OFID) Miscellaneous All About the AAP Recommended Immunization Schedule (healthychildren.org) Recommended Childhood and Adolescent Immunization Schedule: United States, 2026: Policy Statement (American Academy of Pediatrics: Pediatrics) Feeling the Vibes: An Investigation into Resident Antibiotic Prescribing Practices (OFID) Music is by Ronald Jenkees Information on this podcast should not be considered as medical advice.

In this key episode of Parallax, Dr Ankur Kalra sits down with Prof Naveed Sattar to explore how recent therapeutic breakthroughs are fundamentally reshaping the cardiologist's approach to diabetes management. Through real-world case discussions, Dr Sattar demonstrates practical decision-making for patients across the spectrum - from pre-diabetes to established CAD with Type 2 diabetes. He addresses the tension between robust evidence and cost barriers that limit widespread implementation, while acknowledging unprecedented patient demand driven by genuine quality of life improvements. The conversation concludes with insights on obesogenic environments and the hope that increased competition will ultimately democratize access to these transformative therapies. Questions and comments can be sent to "podcast@radcliffe-group.com" and may be answered by Ankur in the next episode. Host: @AnkurKalraMD and produced by: @RadcliffeCardio Parallax is Ranked in the Top 100 Health Science Podcasts (#48) by Million Podcasts.

Dr. Tesha Monteith and Dr. Michael Eller discuss the implications of CGRP therapies in migraine treatment, particularly for patients with vascular risk factors or a history of stroke.  Show citation: Eller MT, Schwarzová K, Gufler L, et al. CGRP-Targeted Migraine Therapies in Patients With Vascular Risk Factors or Stroke: A Review. Neurology. 2025;105(2):e213852. doi:10.1212/WNL.0000000000213852  Show transcript:  Dr. Tesha Monteith: Hi, this is Tesha Monteith with the Neurology Minute. I've just been speaking with Michael Eller from the Department of Neurology Medical University of Innsbruck, Austria on the neurology podcast on his paper, CGRP Targeted Migraine Therapies in Patients with Vascular Risk Factors or Stroke: A Review. Hi, Michael. Dr. Michael Eller: Hello. Dr. Tesha Monteith: Why don't you summarize your general approach to use of CGRP targeted therapies in patients that might be at risk for vascular events when considering safety? Dr. Michael Eller: Yeah. About acute vascular events, we should stop CGLP targeted drugs immediately. When we come to post-stroke, we should reassess the necessity of these targeted treatments after recovery. We suggest a minimum of three months pause after ischemic stroke to allow early recovery and remodeling, and then restart only after individualized benefit risk review. In high-risk primary prevention, so no stroke yet, but elevated risk, if the patients are 65 years or older with established cardiovascular disease, we should prefer traditional preventives. And if CGLP targeted therapy is essential, we should consider Gepants cautiously due to their shorter half lives. We should avoid CGLP targeted treatments in small vessel disease, distal stenosis, Raynaud's phenomenon, and uncontrolled hypertension. For acute migraine treatment, we can consider gepants or ditans as alternatives to triptans and NSAIDs in relevant stroke risk or post-stroke patients, individualized to comorbidities. Dr. Tesha Monteith: Great. And we should say that the label updates include hypertension and Raynaud's phenomenon as potential vascular complications. Otherwise, these are more theoretical risks based on what we know about CGRP. Dr. Michael Eller: Yes, I totally agree because large studies did not show any elevated cardiovascular risk signals. And for post-marketing databases, we did not see any elevated cardiovascular risk so far. However, in pre-clinical settings, studies showed large infarct size in pretreated mice. Dr. Tesha Monteith: Great. Well, thank you again for doing this work. It was a phenomenal read and congratulations. Dr. Michael Eller: Thank you. Dr. Tesha Monteith: This is Tesha Monteith. Thank you for listening to the Neurology Minute.

Preeclampsia is one of those pregnancy conditions that gets mentioned often, explained poorly, and frequently dismissed until it suddenly isn't. In this episode, HeHe sits down with Dr. Dallas Reed to pull back the curtain on what preeclampsia actually is, how it shows up, and what expectant parents deserve to understand long before things feel urgent. Together, they break down the basics in a way that's clear and human, including how common preeclampsia really is, what symptoms to take seriously, and how to make sense of blood pressure readings and pregnancy-related hypertension diagnoses. Dr. Reed explains the differences between severe and non-severe preeclampsia, what monitoring can look like before and after 37 weeks, and why postpartum preeclampsia deserves more attention than it often gets. The conversation also explores prevention and management, including lifestyle considerations, aspirin use, and how care plans may differ depending on risk level, gestational age, and whether someone is being monitored inpatient or outpatient. A major focus of the episode is the future of personalized maternal care, including a deep dive into the Encompass test. This new RNA-based blood test, available between 18 and 22 weeks, helps identify pregnancies at higher risk for preeclampsia and pairs that insight with an evidence-based action plan and virtual support. Dr. Reed shares how this type of testing may change the way providers and families approach monitoring, communication, and early intervention, including potential benefits for out-of-hospital birth settings. This episode is grounded, evidence-based, and empowering, offering expectant parents tools, language, and understanding so they can participate confidently in their care rather than feeling blindsided by it.   TIMESTAMPS 00:00 Introduction to Preeclampsia 00:56 Welcome to The Birth Lounge Podcast 01:39 Features of The Birth Lounge App 03:00 Pregnancy and Postpartum Articles 04:54 Introduction to Today's Episode 07:47 Discussion with Dr. Dallas Reed 08:35 Understanding Preeclampsia 10:46 Symptoms and Diagnosis 18:56 Managing Blood Pressure During Pregnancy 22:37 Risk Factors and Prevention 31:59 Strategies to Prevent Preeclampsia 32:29 Healthy Lifestyle Recommendations 33:37 Monitoring and Follow-Up 35:05 Risks and Complications of Preeclampsia 37:05 Postpartum Preeclampsia 39:20 Managing Preeclampsia Before 37 Weeks 41:20 Inpatient Care and Medications 46:22 Understanding the Encompass Test 53:06 Benefits of the Encompass Test for Home Births 58:19 Final Thoughts and Resources   Guest Bio: Dr. Dallas Reed, practicing OBGYN, medical geneticist and advisor to Mirvie, a company delivering data-driven solutions for predictive and preventive care in pregnancy. Mirvie recently launched Encompass, which is the first RNA-based blood test to predict preeclampsia risk, combined with an evidence-based preventive action plan and virtual assistant to guide individualized support and care.    SOCIAL MEDIA: Connect with HeHe on Instagram  Connect with Mirvie on IG    BIRTH EDUCATION: Join The Birth Lounge for judgment-free, evidence-based childbirth education that shows you exactly how to navigate hospital policies, avoid unnecessary interventions, and have a trauma-free labor experience, all while feeling wildly supported every step of the way Want prep delivered straight to your phone? Download The Birth Lounge App for bite-sized birth and postpartum tools you can use anytime, anywhere. And if you haven't grabbed it yet… Snag my free Pitocin Guide to understand the risks, benefits, and red flags your provider may not be telling you about, so you can make informed, powerful decisions in labor.  

Dr. Tesha Monteith talks with Dr. Michael Eller about the implications of CGRP therapies in migraine treatment, particularly for patients with vascular risk factors or a history of stroke.  Read the related article in Neurology®. Disclosures can be found at Neurology.org. 

Psychogenic nonepileptic seizures (PNES) are common, often misunderstood, and increasingly encountered in pediatric emergency care. These events closely resemble epileptic seizures but arise from abnormal brain network functioning rather than epileptiform activity. In this episode of PEM Currents, we review the epidemiology, pathophysiology, and clinical features of PNES in children and adolescents, with a practical focus on Emergency Department recognition, diagnostic strategy, and management. Particular emphasis is placed on seizure semiology, avoiding iatrogenic harm, communicating the diagnosis compassionately, and understanding how early identification and referral to cognitive behavioral therapy can dramatically improve long-term outcomes. Learning Objectives Identify key epidemiologic trends, risk factors, and semiological features that help differentiate psychogenic nonepileptic seizures from epileptic seizures in pediatric patients presenting to the Emergency Department. Apply an evidence-based Emergency Department approach to the evaluation and initial management of suspected PNES, including strategies to avoid unnecessary escalation of care and medication exposure. Demonstrate effective, patient- and family-centered communication techniques for explaining the diagnosis of PNES and facilitating timely referral to appropriate outpatient therapy. References Sawchuk T, Buchhalter J, Senft B. Psychogenic Nonepileptic Seizures in Children-Prospective Validation of a Clinical Care Pathway & Risk Factors for Treatment Outcome. Epilepsy & Behavior. 2020;105:106971. (PMID: 32126506) Fredwall M, Terry D, Enciso L, et al. Outcomes of Children and Adolescents 1 Year After Being Seen in a Multidisciplinary Psychogenic Nonepileptic Seizures Clinic. Epilepsia. 2021;62(10):2528-2538. (PMID: 34339046) Sawchuk T, Buchhalter J. Psychogenic Nonepileptic Seizures in Children - Psychological Presentation, Treatment, and Short-Term Outcomes. Epilepsy & Behavior. 2015;52(Pt A):49-56. (PMID: 26409129) Labudda K, Frauenheim M, Miller I, et al. Outcome of CBT-based Multimodal Psychotherapy in Patients With Psychogenic Nonepileptic Seizures: A Prospective Naturalistic Study. Epilepsy & Behavior. 2020;106:107029. (PMID: 32213454) Transcript This transcript was generated using Descript automated transcription software and has been reviewed and edited for accuracy by the episode's author. Edits were limited to correcting names, titles, medical terminology, and transcription errors. The content reflects the original spoken audio and was not substantively altered. Welcome to PEM Currents: The Pediatric Emergency Medicine Podcast. As always, I'm your host, Brad Sobolewski, and today we are talking about psychogenic non-epileptic seizures, or PNES. Now, this is a diagnosis that often creates a lot of uncertainty in the Emergency Department. These episodes can be very scary for families and caregivers and schools. And if we mishandle the diagnosis, it can lead to unnecessary testing, medication exposure, ICU admissions, and long-term harm. This episode's gonna focus on how to recognize PNES in pediatric patients, how we make the diagnosis, what the evidence says about management and outcomes, and how what we do and what we say in the Emergency Department directly affects patients, families, and prognosis. Psychogenic non-epileptic seizures are paroxysmal events that resemble epileptic seizures but occur without epileptiform EEG activity. They're now best understood as a subtype of functional neurological symptom disorder, specifically functional or dissociative seizures. Historically, these events were commonly referred to as pseudo-seizures, and that term still comes up frequently in the ED, in documentation, and sometimes from families themselves. The problem is that pseudo implies false, fake, or voluntary, and that implication is incorrect and harmful. These episodes are real, involuntary, and distressing, even though they're not epileptic. Preferred terminology includes psychogenic non-epileptic seizures, or PNES, functional seizures, or dissociative seizures. And PNES is not a diagnosis of exclusion, and it does not require identification of psychological trauma or psychiatric disease. The diagnosis is based on positive clinical features, ideally supported by video-EEG, and management begins with clear, compassionate communication. The overall incidence of PNES shows a clear increase over time, particularly from the late 1990s through the mid-2010s. This probably reflects improved recognition and access to diagnostic services, though a true increase in occurrence can't be excluded. Comorbidity with epilepsy is really common and clinically important. Fourteen to forty-six percent of pediatric patients with PNES also have epilepsy, which frequently complicates diagnosis and contributes to diagnostic delay. Teenagers account for the highest proportion of patients with PNES, especially 15- to 19-year-olds. Surprisingly, kids under six are about one fourth of all cases, so it's not just teenagers. We often make the diagnosis of PNES in epilepsy monitoring units. So among children undergoing video-EEG, about 15 to 19 percent may ultimately be diagnosed with PNES. And paroxysmal non-epileptic events in tertiary epilepsy monitoring units account for about 15 percent of all monitored patients. Okay, but what is PNES? Well, it's best understood as a disorder of abnormal brain network functioning. It's not structural disease. The core mechanisms at play include altered attention and expectation, impaired integration of motor control and awareness, and dissociation during events. So the patients are not necessarily aware that this is happening. Psychological and psychosocial features are common but not required for diagnosis and may be less prevalent in pediatric populations as compared with adults. So PNES is a brain-based disorder. It's not conscious behavior, it's not malingering, and it's not under voluntary control. Children and adolescents with PNES have much higher rates of psychiatric comorbidities and psychosocial stressors compared to both healthy controls and children with epilepsy alone. Psychiatric disorders are present in about 40 percent of pediatric PNES patients, both before and after the diagnosis. Anxiety is seen in 58 percent, depression in 31 percent, and ADHD in 35 percent. Compared to kids with epilepsy, the risk of psychiatric disorders in PNES is nearly double. Compared to healthy controls, it is up to eight times higher. And there's a distinct somatopsychiatric profile that strongly predicts diagnosis of PNES. This includes multiple medical complaints, psychiatric symptoms, high anxiety sensitivity, and solitary emotional coping. This profile, if you've got all four of them, carries an odds ratio of 15 for PNES. Comorbid epilepsy occurs in 14 to 23 percent of pediatric PNES cases, and it's associated with intellectual disability and prolonged diagnostic delay. And finally, across all demographic strata, anxiety is the most consistent predictor of PNES. Making the diagnosis is really hard. It really depends on a careful history and detailed analysis of the events. There's no single feature that helps us make the diagnosis. So some of the features of the spells or events that have high specificity for PNES include long duration, so typically greater than three minutes, fluctuating or asynchronous limb movements, pelvic thrusting or side-to-side head movements, ictal eye closure, often with resisted eyelid opening, ictal crying or vocalization, recall of ictal events, and rare association with injury. Younger children often present with unresponsiveness. Adolescents more commonly demonstrate prominent motor symptoms. In pediatric cohorts, we most frequently see rhythmic motor activity in about 27 percent, and complex motor movements and dialeptic events in approximately 18 percent each. Features that argue against PNES include sustained cyanosis with hypoxia, true lateral tongue biting, stereotyped events that are identical each time, clear postictal confusion or lethargy, and obviously epileptic EEG changes during the events themselves. Now there are some additional historical and contextual clues that can help us make the diagnosis as well. If the events occur in the presence of others, if they occur during stressful situations, if there are psychosocial stressors or trauma history, a lack of response to antiepileptic drugs, or the absence of postictal confusion, this may suggest PNES. Lower socioeconomic status, Medicaid insurance, homelessness, and substance use are also associated with PNES risk. While some of these features increase suspicion, again, video-EEG remains the diagnostic gold standard. We do not have video-EEG in the ED. But during monitoring, typical events are ideally captured and epileptiform activity is not seen on the EEG recording. Video-EEG is not feasible for every single diagnosis. You can make a probable PNES diagnosis with a very accurate clinical history, a vivid description of the signs and appearance of the events, and reassuring interictal EEG findings. Normal labs and normal imaging do not make the diagnosis. Psychiatric comorbidities are not required. The diagnosis, again, rests on positive clinical features. If the patient can't be placed on video-EEG in a monitoring unit, and if they have an EEG in between events and it's normal, that can be supportive as well. So what if you have a patient with PNES in the Emergency Department? Step one, stabilize airway, breathing, circulation. Take care of the patient in front of you and keep them safe. Use seizure pads and precautions and keep them from falling off the bed or accidentally injuring themselves. A family member or another team member can help with this. Avoid reflexively escalating. If you are witnessing a PNES event in front of you, and if they're protecting their airway, oxygenating, and hemodynamically stable, avoid repeated benzodiazepines. Avoid intubating them unless clearly indicated, and avoid reflexively loading them with antiseizure medications such as levetiracetam or valproic acid. Take a focused history. You've gotta find out if they have a prior epilepsy diagnosis. Have they had EEGs before? What triggered today's event? Do they have a psychiatric history? Does the patient have school stressors or family conflict? And then is there any recent illness or injury? Only order labs and imaging when clinically indicated. EEG is not widely available in the Emergency Department. We definitely shouldn't say things like, “this isn't a real seizure,” or use outdated terms like pseudo-seizure. Don't say it's all psychological, and please do not imply that the patient is faking. If you see a patient and you think it's PNES, you're smart, you're probably right, but don't promise diagnostic certainty at first presentation. Remember, a sizable proportion of these patients actually do have epilepsy, and referring them to neurology and getting definitive testing can really help clarify the diagnosis. Communication errors, especially early on, worsen outcomes. One of the most difficult things is actually explaining what's going on to families and caregivers. So here's a suggestion. You could say something like: “What your child is experiencing looks like a seizure, but it's not caused by abnormal electrical activity in the brain. Instead, it's what we call a functional seizure, where the brain temporarily loses control of movement and awareness. These episodes are real and involuntary. The good news is that this condition is treatable, especially when we address it early.” The core treatment of PNES is CBT-based psychotherapy, or cognitive behavioral therapy. That's the standard of care. Typical treatment involves 12 to 14 sessions focused on identifying triggers, modifying maladaptive cognitions, and building coping strategies. Almost two thirds of patients achieve full remission with treatment. About a quarter achieve partial remission. Combined improvement rates reach up to 90 percent at 12 months. Additional issues that neurologists, psychologists, and psychiatrists often face include safe tapering of antiseizure medications when epilepsy has been excluded, treatment of comorbid anxiety or depression, coordinating care between neurology and mental health professionals, and providing education for schools on event management. Schools often witness these events and call prehospital professionals who want to keep patients safe. Benzodiazepines are sometimes given, exposing patients to additional risk. This requires health system-level and outpatient collaboration. Overall, early diagnosis and treatment of PNES is critical. Connection to counseling within one month of diagnosis is the strongest predictor of remission. PNES duration longer than 12 months before treatment significantly reduces the likelihood of remission. Video-EEG confirmation alone does not predict positive outcomes. Not every patient needs admission to a video-EEG unit. Quality of communication and speed of treatment, especially CBT-based therapy, matter the most. Overall, the prognosis for most patients with PNES is actually quite favorable. There are sustained reductions in events along with improvements in mental health comorbidities. Quality of life and psychosocial functioning improve, and patients use healthcare services less frequently. So here are some take-home points about psychogenic non-epileptic seizures, or PNES. Pseudo-seizure and similar terms are outdated and misleading. Do not use them. PNES are real, involuntary, brain-based events. Diagnosis relies on positive clinical features, what the events look like and when they happen, not normal lab tests or CT scans. Early recognition and diagnosis, and rapid referral to cognitive behavioral therapy, change patients' lives. If you suspect PNES, get neurology and mental health professionals involved as soon as possible. Alright, that's all I've got for this episode. I hope you found it educational. Having seen these events many times over the years, I recognize how scary they can be for families, schools, and our prehospital colleagues. It's up to us to think in advance about how we're going to talk to patients and families and develop strategies to help children who are suffering from PNES events. If you've got feedback about this episode, send it my way. Likewise, like, rate, and review, as my teenagers would say, and share this episode with a colleague if you think it would be beneficial. For PEM Currents: The Pediatric Emergency Medicine Podcast, this has been Brad Sobolewski. See you next time.

Send us a textIn this episode of PT Snacks Podcast, host Kasey dives deep into patellar dislocation and the medial patellofemoral ligament (MPFL). Learn about the anatomy, common causes, and risk factors of patellar dislocations, alongside assessment techniques and treatment options. Whether you're a physical therapist or PT student, this episode offers valuable insights into managing both non-operative and post-operative care for patients. Kasey also discusses patient readiness for returning to sports, highlighting the importance of both physiological and psychological factors. Tune in and expand your knowledge on handling one of the most common knee injuries.00:00 Welcome to PT Snacks Podcast00:14 Introduction to MPFL and Patellar Dislocation01:18 Understanding the Medial Patellofemoral Ligament (MPFL)03:02 Risk Factors for Patellar Dislocation05:37 Assessment of Patellar Dislocation07:31 Treatment Approaches for Patellar Dislocation09:01 Rehabilitation and Return to Sport12:15 Summary and Additional Resources13:12 Closing Remarks and AnnouncementsSupport the showNeed CEUs? Unlock unlimited online courses, live webinars, and certification-prep programs with MedBridge. You'll get: Thousands of accredited, evidence-based courses across multiple specialties (PT, OT, AT, SLP) that count for state-license CEUs. Access anytime, from your office, phone, or home—perfect for busy clinicians. One annual subscription, no per-course fee. Special offers: Use code PTSNACKSPODCAST at checkout and save over $100. Students use code PTSNACKSPODCASTSTUDENT for a discounted annual plan. Studying for the NPTE? Check out PT Final Exam — they've helped thousands of students pass with confidence. Use code PTSnacks at checkout for a discount. Stay Connected! Follow so you never miss an episode. Send your questions via email to ptsnackspodcast@gmail.com Join the email list ...

This is one of the most difficult and meaningful conversations Space for Life has ever held.In this episode, host Tommy Thompson is joined by David Dwight, Senior Pastor at Hope Church Richmond, and Ray Paul, National Board Chair of the American Foundation for Suicide Prevention. Together, they share deeply personal stories of losing close family members to suicide and reflect on what it means to grieve, to care for one another, and to hold hope in the midst of profound loss.Listener discretion is advised. This is a heavy and sensitive topic, and we encourage you to listen at your own pace and with support if needed.This conversation is rooted in lived experience, not theory. With honesty, compassion, and care, they explore:What makes suicide-related grief uniquely complexHow to recognize warning signs and risk factorsHow to talk about suicide without shame, fear, or judgmentThe role of community, presence, and faith in healingHow we can better support both those who are grieving and those who may be at riskThis episode is for anyone who has lost someone they love, is walking alongside someone who is struggling, or wants to learn how to respond with greater care and understanding in these moments.Important Support NoteIf you or someone you love is struggling or in crisis, help is available. In the United States, you can call or text 988, the Suicide & Crisis Lifeline, to connect with trained counselors 24/7.You are not alone.Timestamps00:00 Introduction to a Difficult Conversation 03:49 Personal Experiences with Suicide 11:27 Understanding Grief and Loss 24:08 The Complexity of Suicide 32:17 Statistics and Prevention Strategies 42:56 Navigating Conversations about Suicide 54:34 The Role of Community and Support 01:06:17 Faith and Understanding in Grief 01:14:35 Final Thoughts and ResourcesKey Themes & TakeawaysSuicide loss carries layers of grief that are often misunderstoodPrevention and compassion must exist togetherWarning signs often show up as subtle changes in behavior or moodAsking direct questions and listening carefully can save livesPresence matters more than having the “right” wordsThe way someone dies does not define the value or meaning of their lifeHealing often happens in community, not isolationResources MentionedAmerican Foundation for Suicide Prevention (AFSP) https://afsp.orgWhat to Do When Someone Is at Risk https://afsp.org/what-to-do-when-someone-is-at-risk/Risk Factors, Protective Factors, and Warning Signs https://afsp.org/risk-factors-protective-factors-and-warning-signs/Suicide & Crisis Lifeline (U.S.) Call or text 988Love the show? Subscribe, rate, review, and share! http://tommythompson.org

Five articles from the January 2026 issue summarized in five minutes, with the addition of a brief editorial commentary. The 5-in-5 feature is designed to give readers an overview of articles that may pique their interest and encourage more detailed reading. It may also be used by busy readers who would prefer a brief audio summary in order to select the articles they want to read in full. The featured articles this month are: Risk Factors for Progression to Glenohumeral Arthritis After Arthroscopic Anterior Stabilization in a Young and High-Demand Population Characterizing the Transition Zone Between the Meniscotibial Ligament and the Medial Meniscus: A Hidden Trigger for Ramp Lesions Rates of Arthrofibrosis in Adolescent Patients After ACL Reconstruction Using Hamstring Autograft With or Without Lateral Extra-articular Tenodesis Long-term Outcomes After Hip Arthroscopy for Femoroacetabular Impingement Syndrome in Master Athletes: A Propensity-Matched Study With Mean 10-Year Follow-up Functional, Radiological, and Scapular Motion Evaluation of Surgical Versus Nonsurgical Treatment of Type 3 Acromioclavicular Dislocations: A Randomized Controlled Trial With 24 months' Follow-up Click here to read the articles.

Dr. Margarita Fedorova outlines how genetic, environmental, and pathological factors interact in Parkinson's disease and what this means for patient counseling.  Show citation:  Blauwendraat C, Morris HR, Van Keuren-Jensen K, Noyce AJ, Singleton AB. The temporal order of genetic, environmental, and pathological risk factors in Parkinson's disease: paving the way to prevention. Lancet Neurol. 2025;24(11):969-975. doi:10.1016/S1474-4422(25)00271-6  Show transcript:  Dr. Margarita Federova: Welcome to Neurology Minute. My name is Margarita Fedorova, and I'm a neurology resident at the Cleveland Clinic. Today we're exploring a framework for understanding how genetic, environmental, and pathological factors interact in Parkinson's disease and what this means for how we counsel our patients. A personal view paper by Blauwendraat and colleagues, published in The Lancet Neurology in September 2025, addresses a critical question. We've identified over 100 genetic loci for Parkinson's, but how do they act? The common saying is genetics loads the gun and environment pulls the trigger, but this paper suggests the relationship may be more complex. The key tool here is alpha-synuclein seeding amplification assays or SAAs. These detect misfolded alpha-synuclein protein in cerebrospinal fluid. Over 90% of Parkinson's patients test positive for misfolded alpha-synuclein using this assay. But here's what's notable. 2% to 16% of neurologically healthy older adults also test positive with prevalence increasing with age. This means there are more asymptomatic people with detectable alpha-synuclein pathology than people with actual Parkinson's disease. Most of these asymptomatic individuals will never develop symptoms. This raises an important question. What determines who converts to a disease and who doesn't? By integrating SAA results with genetic data, researchers can examine whether genetic factors drive initial protein misfolding or whether they modulate the response to pathology triggered by environmental or random events. Preliminary data suggests polygenic risk scores don't strongly associate with SAA positivity in healthy older adults. In other words, people with high genetic risk for Parkinson's aren't necessarily more likely to have misfolded alpha-synuclein if they're healthy. This suggests most Parkinson's genetic risk factors may not be causing initial misfolding. Instead, they may be determining what happens afterward, such as whether the pathology progresses to clinical disease. LRRK2 mutations support this model. About 33% of LRRK2 related Parkinson's patients are SAA-negative compared to only 7% in sporadic disease. This means many people with LRRK2 mutations develop Parkinson's without the typical alpha-synuclein pathology. LRRK2 mutations also show varied pathology. Sometimes alpha-synuclein, sometimes tau, sometimes neither. This suggests LRRK2 may modulate responses to different initiating events rather than directly causing protein misfolding. What does this mean for us as clinicians? Asymptomatic SAA-positive individuals could represent a window for intervention. If we can understand what protects them from converting to disease or what triggers that conversion, we could enable earlier identification of at risk individuals and potentially intervene before symptoms develop. The authors call for large scale studies using SAAs in older populations, combined with genetic analysis and longitudinal follow-up. By integrating pathological biomarkers with genetic and environmental data, we can better understand the temporal sequence of events in development of Parkinson's. This approach could fundamentally change how we think about disease prevention and early intervention, potentially allowing us to identify at risk individuals before symptoms appear and develop targeted prevention strategies. That's your neurology minute for today. Keep exploring, and we'll see you next time. If you want to read more, please find the paper by Cornelis Blauwendraat et al titled The Temporal Order of Genetic, Environmental and Pathological Risk Factors in Parkinson's Disease: Paving the Way to Prevention, published online in September 2025 in Lancet Neurology.

Chris Hughen sat down with Franco Impellizzeri to discuss risk factors in sports medicine. We dive into causal versus non-causal mechanisms, challenges in defining risk factors, the importance of transparency in research, the illusion of control in clinic practice, and much more. Watch the full episode: https://youtu.be/_-0yndWOf-w  Episode Resources: Stovitz, 2025 Franco's ResearchGate Franco's X --- Membership: https://e3rehab.com/premium/  Mentoring: https://e3rehab.com/mentoring/ Coaching & Consultations: https://e3rehab.com/coaching/  Rehab & Performance Programs: https://e3rehab.com/programs/  Resource Guides: https://e3rehab.com/resource-guides  Newsletter: https://e3rehab.ck.page/19eae53ac1  --- Follow Us: YouTube: https://www.youtube.com/e3rehab  Instagram: https://www.instagram.com/e3rehab/ X: https://x.com/E3Rehab  LinkedIn: https://www.linkedin.com/company/e3rehab/  Facebook: https://www.facebook.com/e3rehab  --- Podcast Sponsor: Vivo Barefoot: Get 20% off all shoes! - https://www.vivobarefoot.com/e3rehab --- @dr.surdykapt @tony.comella @dr.nicolept @chrishughen @nateh_24 --- This episode was produced by Kody Hughes

In this episode, Dr. Jockers breaks down how common nutrient deficiencies quietly contribute to brain fog, memory loss, and cognitive decline. You will learn why symptoms often blamed on aging may actually be signs of missing key nutrients. The episode sets the foundation for understanding how nutrition directly shapes brain health.   You will learn how deficiencies in magnesium and vitamin D disrupt neurotransmitter balance, increase brain inflammation, and impair mental clarity. Dr. Jockers explains how these imbalances affect mood, focus, and long term cognitive resilience. Subtle warning signs are highlighted that many people overlook.   You will also learn why B12, folate, and vitamin B6 are critical for protecting the brain and nervous system. The episode explores how these nutrients influence oxygen delivery, detoxification, and gene expression. Dr. Jockers shares insights that help connect lab markers with real world cognitive symptoms.   In This Episode:  00:00 Understanding B12 Deficiency in Aging 00:26 Introduction to Nutrient Deficiencies and Brain Health 06:20 The Importance of Magnesium for Brain Function 13:18 Optimizing Vitamin D Levels for Cognitive Health 17:59 The Critical Role of B12 in Brain Health 21:46 B12 Deficiency: A Widespread Issue 24:54 Causes and Risk Factors of B12 Deficiency 28:10 Optimal B12 Levels and Supplementation 32:25 Understanding Folate and Its Importance 38:15 Vitamin B6: Functions and Deficiency Signs 42:56 Conclusion and Final Thoughts   If you want practical, natural strategies to balance your hormones, heal your gut, boost your energy, and slow aging, don't miss The Dr. Josh Axe Show. Dr. Axe blends ancient wisdom with cutting-edge science and brings on world-class experts for unfiltered conversations you won't hear anywhere else. Transform your health from the inside out and subscribe to The Dr. Josh Axe Show, with new episodes every Monday and Thursday.   Support glowing skin, stronger joints, better digestion, and deeper sleep with Paleovalley's 100% Grass-Fed Bone Broth Protein. Unlike most brands that use hides and skins, Paleovalley slow-simmers real beef bones to extract collagen, glycine, and key amino acids that boost metabolism and reduce inflammation. Each scoop delivers 15 grams of collagen and the clinical dose of glycine for better sleep. Get 15% off at paleovalley.com/jockers.   Most tap water contains hidden contaminants that can contribute to fatigue, hormone disruption, and cognitive decline. AquaTru is a countertop water purifier that uses a four stage reverse osmosis system to remove 84 contaminants, including chlorine, lead, PFAS, and microplastics. Unlike standard pitcher filters or bottled water, AquaTru delivers truly purified water with no installation required. It has been featured in Business Insider, Popular Science, and named Best Countertop Water Filter by Good Housekeeping. Save 20% on your AquaTru purifier at aquatru.com using the promo code NUTRITION and try it risk free with a 30 day best tasting water guarantee.     "Magnesium regulates calcium metabolism in neurons. Dysregulated calcium metabolism can lead to neurotoxicity and cause cognitive decline."      Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean TuneIn Radio   Resources: Paleovalley Bone Broth Protein: Save 15% on grass-fed bone broth protein at paleovalley.com/jockers. Visit aquatru.com and use promo code NUTRITION to save 20% on your AquaTru water purifier.   Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https://www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/ If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/ 

About Dr. Raj Dr Raj is a quadruple board certified physician and associate professor at the University of Southern California. He was a co-host on the TNT series Chasing the Cure with Ann Curry, a regular on the TV Show The Doctors for the past 7 seasons and has a weekly medical segment on ABC news Los Angeles. More from Dr. Raj ⁠The Dr. Raj Podcast⁠ ⁠Dr. Raj on Twitter⁠ ⁠Dr. Raj on Instagram⁠ Want more board review content? ⁠USMLE Step 1 Ad-Free Bundle⁠ ⁠Crush Step 1⁠ ⁠Step 2 Secrets⁠ ⁠Beyond the Pearls⁠ ⁠The Dr. Raj Podcast⁠ ⁠Beyond the Pearls Premium⁠ ⁠USMLE Step 3 Review⁠ ⁠MedPrepTGo Step 1 Questions⁠ ⁠MedPrepTGo Step 2 Questions⁠ Learn more about your ad choices. Visit megaphone.fm/adchoices

In this week's episode we've pulled a vault recording from 2025! Blood editor Dr. Laurie Sehn interviews authors Drs. David-Alexandre Trégouët and Johannes Schetelig on their research published in volume 146 issue 19 of Blood journal. Dr. Trégouët's study conducted a genome-wide association study supplemented by transcriptome and Mendelian randomization analyses to identify 28 loci and proteins associated with VTE recurrence risk. This work provides genomic evidence that inherited variants contribute to the risk of VTE recurrence, raising the possibility of a more personalized approach to the prevention of recurrent VTE. The study conducted by Dr. Schetelig and colleagues report the results of a long term trial on patients with poor-response AML, comparing outcomes between patients who received salvage chemotherapy versus immediate transplantation. With no difference in survival rates at 5 years, outcomes seem to be determined mainly by genetic risk factors, age, and comorbidities, therefore challenging the routine use of intensive remission induction before allogeneic transplant in patients with an available donor and underscore the need for novel therapeutic strategies for poor-risk AML.Featured Articles:Molecular Determinants of Thrombosis Recurrence Risk Across Venous Thromboembolism Subtypes Disease risk but not remission status determines transplant outcomes in AML: long-term outcomes of the ASAP trial 

PodChatLive 211: What does ‘risk factor' actually mean, and the biomechanical effects of cushioned running shoesContact us: getinvolved@podchatlive.comLinks from this episode:The Risks of Misunderstanding the Term "Risk Factor": A Primer with Suggestions to Improve Sports MedicineBiomechanical effects of maximal footwear on running

Shingles is a reactivation of the varicella‑zoster virus and poses a substantial burden, particularly for older adults and immunocompromised individuals. During this podcast, experts discuss the evolving epidemiology of shingles, distinguish between typical and atypical presentations across dermatologic, neurologic, and ophthalmic domains. Learners will gain insights into prevention strategies including vaccination and timely antiviral therapy to reduce complications. Claim CE and MOC credit at: https://bit.ly/4qkvOPU

A look at Inflammatory Bowel Disease (IBD), more specifically the two main forms of IBD which are Ulcerative Colitis and Crohn's Disease, going through each condition as well as looking at the differences between Ulcerative Colitis and Crohn's disease. Includes the signs and symptoms of each, including extraintestinal manifestations of inflammatory bowel disease, as well as differences in the histology. PDFs available at: https://rhesusmedicine.com/pages/gastroenterologyConsider subscribing (if you found any of the info useful!): https://www.youtube.com/channel/UCRks8wB6vgz0E7buP0L_5RQ?sub_confirmation=1Buy Us A Coffee!: https://www.buymeacoffee.com/rhesusmedicineTimestamps:0:00 What is Inflammatory Bowel Disease?0:15 Ulcerative Colitis and Crohn's Disease Epidemiology1:08 Signs and Symptoms of Inflammatory Bowel Disease / Signs and Symptoms of Ulcerative Colitis and Crohn's Disease3:19 Extraintestinal Manifestations of Inflammatory Bowel Disease4:48 Inflammatory Bowel Disease Pathology5:07 Risk Factors for Ulcerative Colitis and Crohn's Disease / Risk Factors of Inflammatory Bowel Disease5:47 Diagnosis of Ulcerative Colitis and Crohn's Disease / Inflammatory Bowel Disease Diagnosis6:51 Inflammatory Bowel Disease Histology / Ulcerative Colitis v Crohn's Disease Histology7:52 Treatment of Inflammatory Bowel Disease / Ulcerative Colitis and Crohn's Disease TreatmentLINK TO SOCIAL MEDIA: https://www.instagram.com/rhesusmedicine/ReferencesCrohn's & Colitis Foundation (2019) Updated IBD Factbook. Crohn's & Colitis Foundation. Available at: https://www.Crohn'scolitisfoundation.org/sites/default/files/2019-02/Updated%20IBD%20Factbook.pdfWalfish, A.E. and Ching Companioni, R.A. (2023) ‘Overview of inflammatory bowel disease', MSD Manual Professional Edition. Merck & Co., Inc. Available at: https://www.msdmanuals.com/professional/gastrointestinal-disorders/inflammatory-bowel-disease-ibd/overview-of-inflammatory-bowel-diseaseWaugh, N., Cummins, E., Royle, P. et al. (2013) Comparison of Ulcerative Colitis, Crohn's disease, irritable bowel syndrome and coeliac disease, in Faecal calprotectin testing for differentiating amongst inflammatory and non-inflammatory bowel diseases: systematic review and economic evaluation. Southampton: NIHR Journals Library. Available at: https://www.ncbi.nlm.nih.gov/books/NBK261307/Disclaimer: Please remember this video and all content from Rhesus Medicine is for educational and entertainment purposes only and is not a guide to diagnose or to treat any form of condition. The content is not to be used to guide clinical practice and is not medical advice. Please consult a healthcare professional for medical advice.

In this video we cover Gastric Cancer / Stomach Cancer, looking at risk factors for it as well as what are the signs and symptoms of Gastric Cancer (with Troisier's sign!). Also includes the most common locations of gastric cancer, how gastric cancer is diagnosed (including staging), and how is gastric cancer treated. PDFs available at: https://rhesusmedicine.com/pages/gastroenterologyFor more medicine videos consider subscribing (if you found any of the info useful!): https://www.youtube.com/channel/UCRks8wB6vgz0E7buP0L_5RQ?sub_confirmation=1Buy Us A Coffee!: https://www.buymeacoffee.com/rhesusmedicineVideo Timestamps:0:00 How common is Gastric Cancer0:10 Risk Factors for Gastric Cancer1:07 Where is Gastric Cancer most common? 1:19 Types of Gastric Cancer1:35 Most Common Site of Gastric Cancer (Which part of the stomach is most commonly affected)1:49 Signs and Symptoms of Gastric Cancer (Gastric Cancer Symptoms) 2:39 What is Troisier's Sign? (Virchows Node)2:51 Gastric Cancer Diagnosis3:10 Gastric Cancer Staging4:03 Gastric Cancer Prognosis4:35 Gastric Cancer TreatmentLINK TO SOCIAL MEDIA: https://www.instagram.com/rhesusmedicine/ReferencesWorld Journal of Gastroenterology, 2008. Role of symptoms in diagnosis and outcome of gastric cancer. World Journal of Gastroenterology, 14(8), pp.1149–1155. [online] Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2690660/. PMCMachlowska, J., Baj, J., Sitarz, M., Maciejewski, R. & Sitarz, R., 2020. Gastric Cancer: Epidemiology, Risk Factors, Classification, Genomic Characteristics and Treatment Strategies. International Journal of Molecular Sciences, 21(11):4012. [online] Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312039/. PubMedWikipedia, 2025. Stomach carcinoma / Gastric cancer. [online] Available at: https://en.wikipedia.org/wiki/Stomach_carcinoma.ScienceDirect Topics, 2025. Stomach carcinoma – Medicine and Dentistry. [online] Available at: https://www.sciencedirect.com/topics/medicine-and-dentistry/stomach-carcinoma. ScienceDirectWorld Health Organization (WHO), 2025. Cancer fact sheet. [online] Available at: https://www.who.int/news-room/fact-sheets/detail/cancer.Disclaimer: Please remember this podcast and all content from Rhesus Medicine is for educational and entertainment purposes only and is not a guide to diagnose or to treat any form of condition. The content is not to be used to guide clinical practice and is not medical advice. Please consult a healthcare professional for medical advice.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/NCPD/AAPA/ASWB-ACE/APA/IPCE information, and to apply for credit, please visit us at PeerView.com/UAH865. CME/MOC/NCPD/AAPA/ASWB-ACE/APA/IPCE credit will be available until December 13, 2026.Remembering Brain Health: Targeting Modifiable Risk Factors and Early Detection of Cognitive Symptoms to Reduce the Burden of Dementia In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, and BrightFocus Foundation. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/NCPD/AAPA/ASWB-ACE/APA/IPCE information, and to apply for credit, please visit us at PeerView.com/UAH865. CME/MOC/NCPD/AAPA/ASWB-ACE/APA/IPCE credit will be available until December 13, 2026.Remembering Brain Health: Targeting Modifiable Risk Factors and Early Detection of Cognitive Symptoms to Reduce the Burden of Dementia In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, and BrightFocus Foundation. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/NCPD/AAPA/ASWB-ACE/APA/IPCE information, and to apply for credit, please visit us at PeerView.com/UAH865. CME/MOC/NCPD/AAPA/ASWB-ACE/APA/IPCE credit will be available until December 13, 2026.Remembering Brain Health: Targeting Modifiable Risk Factors and Early Detection of Cognitive Symptoms to Reduce the Burden of Dementia In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, and BrightFocus Foundation. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/NCPD/AAPA/ASWB-ACE/APA/IPCE information, and to apply for credit, please visit us at PeerView.com/UAH865. CME/MOC/NCPD/AAPA/ASWB-ACE/APA/IPCE credit will be available until December 13, 2026.Remembering Brain Health: Targeting Modifiable Risk Factors and Early Detection of Cognitive Symptoms to Reduce the Burden of Dementia In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, and BrightFocus Foundation. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.

In this week's episode of Unlock Your Life, Jennings breaks down the five critical risk factors every real estate investor must know. Drawing from personal experience, Jennings explains why failure is a better teacher than success and how overconfidence can lead to heartbreak. He methodically explores why investing out-of-market, purchasing older buildings, ignoring location fundamentals, venturing into unfamiliar asset classes, and taking on too many deals simultaneously can devastate your portfolio. This episode delivers a masterclass in risk management and emphasizes that operational excellence- not deal acquisition- is the true secret to longevity in real estate investing. Thanks for listening!

Popular media leverage weak study to criticize RFK Jr.'s rethink of standard recommendations for saturated fat avoidance; Poor quality plant-based diets hike cardio risk; A listener complains his lp(a) is going up with age despite his healthy diet, lifestyle; Scientists pinpoint cocoa ingredient that slows aging; Berry proanthocyanidins preserve brain power; Tattooing may promote inflammation, undermine immunity.

Julie A. Parsons, MDHaberfield Endowed Chair in Pediatric Neuromuscular DisordersProfessor of Clinical Pediatrics and NeurologyUniversity of Colorado School of Medicine, Children's Hospital ColoradoAurora, CO, USANow, with our collective experience, we can at least put together the information that we have in terms of what can we expect and what's the timeline that we expect in terms of our patients having reactions. I will tell you, and I've said this multiple times, when I deliver a gene transfer therapy, I hold my breath for 2 months. Now, maybe it's going to have to be extended to a year, but it's typically at least for 2-3 months. It's like, okay, what's going to happen? You sit on the edge of your seat on pins and needles, going, "Is this kid going to be okay or not?" I think that's the appropriate response to have in terms of the light of things that have happened over time. We have to be really careful.We have a little bit of a framework now to say, when do we need to be really excited? We know that our patients, most all of them, are going to develop a transaminitis, and that ends up happening early on, but we get a couple of peaks. We get really excited that the 4-8 week time point with transaminitis looking for liver failure.The cholestatic liver disease that happened in the patients with X-linked MTM happened a little bit later, so Week 2, all the way out to six months afterwards. The acute cardiomyopathy a little bit earlier, so we're looking a little bit earlier for that effect. TMA, usually the end of the first week to about 2 weeks is when we would expect that to come in. Then the transgene-related myositis and immune-mediated myocarditis, weeks, maybe 2 to a couple of months.How do we adapt our gene transfer programs to the clinical trial experience? I think that there are a couple of points that are important. One is that the outline that I showed you, there are some disease-agnostic issues that come up with transaminitis, with TMA. I think there are some final common pathways related to the immune responses that we see with these patients. Then there are going to be some disease-specific disorders that are going to come up with each of these therapies and agents.We need to have good communication, honestly, in real-time. I still don't know that we have a good mechanism for that as a community, but to share these adverse events that come up so that we can all learn as a collective about what to expect, what to anticipate, and how to best take care of our patients. We know now how we need to monitor patients closely from a laboratory standpoint, from a clinical exam standpoint, and we really need to work on how are we going to mitigate some of these risk issues that we have with these patients.I think the collaborative aspect, particularly at meetings like this, is important. Last year, for the people that were at MDA, you remember that we really spent a lot of time looking at gene transfer delivery. Many of us got together as providers and actually met together to say, "Is there something that we can think about in terms of best practice or consensus in terms of how we would want to manage patients or how we'd want to share information?"Now, actually, on the MDA website, we really do have some guidelines, and there will be a publication coming out shortly that we'll have this available to everybody again. It's not necessarily the right answer, but it's at least from a collective experience, what's the best way that we can go forward? Some of the suggestions were that the adverse events right now, we can put them into some a predictable timeline, but we don't really know all the risks at the time of dosing.We know that gene transfer therapy can be safe for the right patient at the right time for the right disorder. That's really what we want to do. There's a Neurotherapeutic window between efficacy and toxicity. How are we adjusting that? What are we working on to make sure that we're getting that right? The preclinical data is helpful, but it's never the full story. Any time we go from a homogeneous population that we see in a clinical trial to a heterogeneous population, as we throw this out to the world, we're going to have new issues that arise, and we need to be aware and ready for those.We want to be able to predict what happens, but we can't always do that. Then follow-up is so important. The post-marketing study, sharing adverse events, sharing experiences, I think, is really important as well. Clinicians really should be familiar with this entire field before ever delivering gene transfer therapy. I don't think that every site should be delivering gene transfer. I think that from an institutional standpoint, you need to be ready. You need to have a team who knows what they're doing and knows how to handle the issues and the problems, or you need to have lifelines set up in advance if you're going to deliver these treatments.

Depression, also known as major depressive disorder, is projected to be the number 1 cause of disease burden by 2030. We look at the causes and risk factors, the DSM 5 diagnostic criteria, and the treatment of depression.PDFs available here: https://rhesusmedicine.com/pages/psychiatryConsider subscribing (if you found any of the info useful!): https://www.youtube.com/channel/UCRks8wB6vgz0E7buP0L_5RQ?sub_confirmation=1Patreon: https://www.patreon.com/rhesusmedicineBuy Us A Coffee!: https://www.buymeacoffee.com/rhesusmedicineTimestamps:0:00 Major Depressive Disorder0:23 DSM 5 Criteria - Major Depressive Disorder 1:58 Depression Causes & Risk Factors 3:10 Depression Pathophysiology 4:28 Depression Epidemiology 4:59 Depression Diagnosis 5:39 Depression Treatment LINK TO SOCIAL MEDIA: https://www.instagram.com/rhesusmedicine/Reference:Bains, N. & Abdijadid, S., 2023. Major Depressive Disorder. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. [online] Available at: https://www.ncbi.nlm.nih.gov/books/NBK559078/. NCBIPsycom, 2025. DSM-5 depression criteria – Major Depressive Disorder. [online] Available at: https://www.psycom.net/depression/major-depressive-disorder/dsm-5-depression-criteria.Wikipedia, 2025. Major depressive disorder. [online] Available at: https://en.wikipedia.org/wiki/Major_depressive_disorder.National Institute of Mental Health (NIMH), 2025. Depression. [online] Available at: https://www.nimh.nih.gov/health/topics/depression.Bondy, B., 2002. Pathophysiology of depression and mechanisms of treatment. Dialogues in Clinical Neuroscience, 4(1), pp.7–20. [online] Available at: https://www.tandfonline.com/doi/full/10.31887/DCNS.2002.4.1/bbondy. Taylor & Francis OnlineDisclaimer: Please remember this podcast and all content from Rhesus Medicine is for educational and entertainment purposes only and is not a guide to diagnose or to treat any form of condition. The content is not to be used to guide clinical practice and is not medical advice. Please consult a healthcare professional for medical advice.

In this episode, Dr. Jockers explains why parasite symptoms often intensify around the full moon and how changes in light exposure, serotonin, and melatonin can trigger parasite activity. You'll learn why this timing matters and how it creates a unique window for effective cleansing.   You'll also discover the most common signs of parasite overload—many of which are frequently misattributed to stress, poor digestion, or aging. From sleep disturbances and gut issues to skin reactions and inflammation, this episode connects the dots in ways most people never consider.   Finally, you'll learn the foundational principles behind a successful parasite cleanse, including why drainage, gut motility, and immune support matter just as much as killing parasites. Dr. Jockers walks through the strategy while leaving key insights for you to uncover as you listen.     In This Episode:  00:00 Introduction to Full Moon Parasite Cleanse 00:12 Protocol Overview 02:35 Understanding Parasites and Their Impact 07:21 Risk Factors for Parasite Infections 13:50 Lab Tests and Indicators of Parasites 17:40 Steps for Effective Parasite Cleanse 22:19 Conclusion and Final Thoughts     If you want practical, natural strategies to balance your hormones, heal your gut, boost your energy, and slow aging, don't miss The Dr. Josh Axe Show. Dr. Axe blends ancient wisdom with cutting-edge science and brings on world-class experts for unfiltered conversations you won't hear anywhere else. Transform your health from the inside out and subscribe to The Dr. Josh Axe Show, with new episodes every Monday and Thursday.   Support glowing skin, stronger joints, better digestion, and deeper sleep with Paleovalley's 100% Grass-Fed Bone Broth Protein. Unlike most brands that use hides and skins, Paleovalley slow-simmers real beef bones to extract collagen, glycine, and key amino acids that boost metabolism and reduce inflammation. Each scoop delivers 15 grams of collagen and the clinical dose of glycine for better sleep. Get 15% off at paleovalley.com/jockers.     "By the time you're seeing symptoms like indigestion or skin rashes, parasites may already be wreaking havoc inside your gut."      Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean TuneIn Radio     Resources: Paleovalley Bone Broth Protein: Save 15% on grass-fed bone broth protein at paleovalley.com/jockers.   Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https://www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/ If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/ 

Obesity, Hypertension, and Risk Factors in Terms of Prevention and Decreasing the Risk of HfpEF   Guest: Affan Irfan, M.D., Ph.D. Host: Stephen L. Kopecky, M.D.   HFpEF is a type of heart failure where the heart pumps normally but becomes stiff. This leads to fatigue, shortness of breath, and fluid retention. It is closely linked to obesity, hypertension, and metabolic disorders, with cases rising as these conditions become more common.   Topics Discussed: What is HFpEF and its risk factors? How common are obesity and hypertension, and how often do they lead to HFpEF? How do you diagnose HFpEF? How effective are weight loss, diet, and exercise in preventing HFpEF? What medical and public health strategies help reduce these risk factors and HFpEF cases?    Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV and @MayoCVservices. LinkedIn: Mayo Clinic Cardiovascular Services Cardiovascular Education App: The Mayo Clinic Cardiovascular CME App is an innovative educational platform that features cardiology-focused continuing medical education wherever and whenever you need it. Use this app to access other free content and browse upcoming courses. Download it for free in Apple or Google stores today! No CME credit offered for this episode.   Podcast episode transcript found here.

PodChatLive 209: Risk factors for Achilles tendinopathy in runners, and the metabolic effects of carbon plated running shoesContact us: getinvolved@podchatlive.comLinks from this episode:'Runners Are More Intelligent, Smart And Cool Than The Average Person' Says StudyPhysiotherapy is almost as pseudoscientific as osteopathy and chiropracticBiomechanical insights into Achilles tendinopathy risk and protection in runnersMetabolic Effects of Carbon-Plated Running Shoes: A Systematic Review and Meta-analysis

Send us a message with this link, we would love to hear from you. Standard message rates may apply. In this episode of Your Checkup, we break down lipoprotein(a) — a largely inherited form of cholesterol that can significantly increase the risk of heart disease and stroke, even when standard cholesterol numbers look normal. We talk about what Lp(a) is, why it matters, who should be tested, and how it helps explain “unexpected” heart events in otherwise healthy people. While Lp(a) can't currently be lowered with diet or exercise, knowing your level allows you and your care team to be more intentional about prevention by aggressively managing other risk factors like LDL cholesterol, blood pressure, and diabetes. We also discuss what the numbers mean, why most people only need to be tested once, and the promising treatments currently being studied that may change care in the future. References (for Show Notes)Nordestgaard BG, Langsted A. Lipoprotein(a) and Cardiovascular Disease. Lancet. 2024;404(10459):1255-1264.Reyes-Soffer G, et al. AHA Scientific Statement on Lipoprotein(a). Arterioscler Thromb Vasc Biol. 2022;42(1):e48-e60.Di Fusco SA, et al. Lipoprotein(a): Risk Factor and Emerging Target. Heart. 2022;109(1):18-25.Nasrallah N, et al. Lp(a) in Clinical Practice. Eur J Clin Invest. 2025:e70127.Greco A, et al. Lipoprotein(a) as a Pharmacological Target. Circulation. 2025;151(6):400-415.Bess C, Mehta A, Joshi PH. All We Need to Know About Lipoprotein(a). Prog Cardiovasc Dis. 2024;84:27-33.Support the showSubscribe to Our Newsletter! Production and Content: Edward Delesky, MD & Nicole Aruffo, RNArtwork: Olivia Pawlowski

Are you assuming your partner's fertility is “fine” because his semen analysis came back "normal"—and could that be the very thing blocking pregnancy?!Most couples don't realize that 50% of all fertility challenges involve male factors, yet men rarely receive thorough testing. A basic semen analysis only scratches the surface and completely overlooks hidden issues.In this episode, you'll learn...-A clear understanding of why a standard semen analysis does not confirm healthy or optimal sperm—and what deeper issues it often misses.-The hidden male-factor problems that contribute to infertility, poor embryo development, and miscarriage.-The exact steps couples can take right now—including advanced testing, lifestyle upgrades, and targeted support—to rapidly improve sperm quality in as little as 90 days.Press play now to learn how addressing male fertility today can dramatically boost your chances of conceiving, reduce miscarriage risk, and help you build the healthiest family possible.

Send us a textIn episode #164 we discussed some important science around heat and performance with Dr. Melani Kelly:The differences between heat exhaustion, heat injury, and heat stroke, and the role hydration and nutrition play in preventing them.How certain medications can increase the risk of exertional heat illness, and how they can alter our physiological responsesPractical advice and strategies for athletes on preparing for and managing heat exposure during training and competition.Melani Kelly is an Assistant Professor at Utah Valley University, where she teaches and mentors students in the Department of Exercise Science and Outdoor Recreation. She holds a PhD in Exercise Physiology from the University of Kansas, a MS in Sport and Exercise Sciences from West Texas A&M, and a BS in Athletic Training from Eastern Washington University. Dr. Kelly's current research focuses on identifying exertional heat illness (EHI) risk factors and assessing kidney damage in 100-mile ultramarathon runners. Her work has highlighted various risk factors, including how mental health medications may increase EHI risk, and individualized gastrointestinal responses to limit damage and perceived symptoms experienced with physical activityPlease note that this podcast is created strictly for educational purposes and should never be used for medical diagnosis or treatment.Follow Dr. Melani Kelly: Google Scholar: scholar.google.com/citations?user=vBhJYmsAAAAJ&hl=enSelf Reported Exertional Heat Illness and Risk Factors among Collegiate Marching Band ArtistsCore Body Temperature in Collegiate Marching Band Artists During Rehearsals and PerformancesCollegiate Marching Band Artists Experience High Core Body Temperature during Rehearsals and PerformancesMentioned:Drugs.com: https://www.drugs.com/PubMed: https://pubmed.ncbi.nlm.nih.gov/NIH Stat Pearls: https://www.ncbi.nlm.nih.gov/books/NBK430685/MORE NR New customers save 10% off all products on our website with the code NEWPOD10 If you would like to work with our practitioners, click here: https://nutritional-revolution.com/work-with-us/ Save 50% off your 1st Trifecta Nutrition order with code NR50: https://trifectanutrition.llbyf9.net/qnNk05 Save 20% on all supplements at our trusted online source: https://us.fullscript.com/welcome/kchannell Join Nutritional Revolution's The Feed Club to get $20 off right away with an additional $20 Feed credit drop every 90 days.: https://thefeed.com/teams/nutritional-revolution If you're interested in sponsoring Nutritional Revolution Podcast, shoot us an email at nutritionalrev@gmail.com.

An L.A. based podcast brought to you by two forensic psychologists who dissect the intersections where true crime, forensic psychology, and entertainment meet. Episode Description: Crazy In Love: Erotomania Dr. Scott & Dr. Shiloh get into the subcategory of Delusional Disorder, Erotomania; to have the delusional or false belief of a secret or known admirer. This disorder is often the trigger for obsessive celebrity stalkers and has been the cause for numerous violent acts. The docs explore the origin, criteria, and research of this rare phenomenon and cover the cases of John Hinkley Jr., Margaret Mary Ray, and the shooter who killed rising star Christina Grimmie. Related episode: Stalking: The Crime of the 90's https://anchor.fm/lansc/episodes/25--Stalking-The-Crime-of-the-90s-e537ff Donate to the Christina Grimmie Foundation here: https://christinagrimmiefoundation.org/ Mentions: Lenora Consulting LLC https://www.lenoraclairellc.com/ 10ish Podcast https://www.10ishpod.com/ Resources Braun, Claude, and Sabrina Suffren. "A General Neuropsychological Model of Delusion." ResearchGate, Taylor & Francis (Routledge), Mar. 2010, www.researchgate.net/publication/41670340_A_general_neuropsychological_model_of_delusion. Accessed 26 Nov. 2021. Brüne, Martin. "Erotomanic Stalking in Evolutionary Perspective." Behavioral Sciences & the Law, vol. 21, no. 1, 16 Dec. 2002, pp. 83–88, pubmed.ncbi.nlm.nih.gov/12579619/#:~:text=Erotomania%2C%20the%20delusion%20of%20being,concerning%20prevalence%20rates%20and%20behavior.&text=The%20evolutionary%20perspective%20may%20provide,understanding%20of%20forensically%20relevant%20behaviors., 10.1002/bsl.518. Accessed 26 Nov. 2021. Christina Grimmie: The Murder of a Rising Star. Orlando Sentinel, 4 June 2018, disc 1-2. Podcast. "De Clerambault Syndrome (Erotomania) in the Criminal Justice System: Another Look at This Recurring Problem | Office of Justice Programs." Ojp.gov, 2021, www.ojp.gov/ncjrs/virtual-library/abstracts/de-clerambault-syndrome-erotomania-criminal-justice-system-another. Accessed 26 Nov. 2021. Ghosh, Tulika, and Minkesh Chowdhary. De Clerambault Syndrome: Current Perspective. Www.intechopen.com, IntechOpen, 12 May 2021, www.intechopen.com/chapters/72361. Accessed 27 Nov. 2021. Hayes, Crystal. "Forgotten Story of Singer's Legacy, Man Who Killed Her." Courier-Post, 18 Dec. 2016, www.courierpostonline.com/story/news/local/south-jersey/2016/12/18/forgotten-story-christina-grimmie-and-man-who-killed-her/95585040/. He Loves Me, He Loves Me Not. Directed by Laetitia Colombani, Samuel Goldwyn Films, 2003. Harmon RB;Rosner R;Owens H. "Obsessional Harassment and Erotomania in a Criminal Court Population." Journal of Forensic Sciences, vol. 40, no. 2, 2011, pubmed.ncbi.nlm.nih.gov/7602275/. Accessed 26 Nov. 2021. "How History Changed Anita Hill (Published 2019)." The New York Times, 2021, www.nytimes.com/2019/06/17/us/anita-hill-women-power.html. Accessed 27 Nov. 2021. Jamaluddin, Ruzita. "Same Gender Erotomania: When the Psychiatrist Became the Delusional Theme—a Case Report and Literature Review." Case Reports in Psychiatry, vol. 2021, 1 Sept. 2021, p. e7463272, www.hindawi.com/journals/crips/2021/7463272/, 10.1155/2021/7463272. Kelly, B. D., et al. "Delusion and Desire: Erotomania Revisited." Acta Psychiatrica Scandinavica, vol. 102, no. 1, July 2000, pp. 74–76, pubmed.ncbi.nlm.nih.gov/10892614/, 10.1034/j.1600-0447.2000.102001074.x. Accessed 26 Nov. 2021. Meloy, J. CASE REPORT Erotomania, Triangulation, and Homicide. "Risk Factors for Stalking Violence, Persistence, and Recurrence." The Journal of Forensic Psychiatry & Psychology, 2017, www.tandfonline.com/doi/abs/10.1080/14789949.2016.1247188?journalCode=rjfp20&. Accessed 26 Nov. 2021. Safeekh, AT, and Denzil Pinto. "Venlafaxine-Induced Psychotic Symptoms." Indian Journal of Psychiatry, vol. 51, no. 4, 2009, p. 308, www.ncbi.nlm.nih.gov/pmc/articles/PMC2802382/, 10.4103/0019-5545.58301. Accessed 26 Nov. 2021. Sederholm, Jillian. "Gunman Who Killed 'the Voice' Singer Had Extra Ammo, Knife: Police." NBC News, 11 June 2016, www.nbcnews.com/news/us-news/voice-singer-christina-grimmie-shot-after-florida-concert-n590161. Accessed 27 Nov. 2021. Shanee Edwards. "I Just Discovered the Crazy World of Erotomania Thanks to HBO's Confirmation." SheKnows, SheKnows, 17 Apr. 2016, www.sheknows.com/entertainment/articles/1119045/erotomania-and-confirmation-hbo/. Accessed 26 Nov. 2021.

Join Dr. Martin in today's episode of The Doctor Is In Podcast.  

Join Dr. Martin in today's episode of The Doctor Is In Podcast.  

Welcome to the Choosing Wisely Campaign series! This is the fifth and final episode of our 5-part series exploring the ABIM Foundation's Choosing Wisely Lists. This campaign aims to promote conversations between clinicians and patients to avoid unnecessary medical tests, treatments, and procedures. Our last case-based episode focuses on a school-aged male presenting with new-onset enuresis. After a discussion of the differential diagnosis and evidence-based evaluation strategies, we apply recommendations from multiple AAP Choosing Wisely lists to create a care plan that is safe, resource-conscious, and child-centered. Throughout this episode, we'll highlight how ethical care principles—beneficence, nonmaleficence, autonomy, and justice—guide high-value decision-making and help us avoid unnecessary imaging, laboratory studies, and interventions that add cost without improving outcomes. This familiar case in pediatrics is worthy of a rewind to relisten to a throwback episode that will reinforce your skills and emphasize the clinical diagnosis and management without added diagnostics, referrals, or medications.  This case closes out our series on Choosing Wisely in Pediatrics, but the principles we've explored should continue to inform your practice every day. If you missed earlier episodes, rewind to learn more about the campaign's background and listen to cases on fever and cough, gastroenterology presentations, and more.   Series Learning Objectives: Introduction to the Choosing Wisely Campaign: Understand the origins, historical precedent, and primary goals of the campaign. Case-Based Applications: Explore five common presentations in primary and acute care pediatrics, applying concepts from various Choosing Wisely lists to guide management and resource stewardship. Effective Communication: Learn strategies for engaging in tough conversations with parents and colleagues to create allies and ensure evidence-based practices are followed. Modified rMETRIQ Score: 15/15 What does this mean?   Competencies: AACN Essentials: 1: 1.1 g; 1.2 f; 1.3 d, e 2: 2.1 d, e; 2.2 g; 2.4 f, g; 2.5 h, i, j, k 7: 7.2 g, h, k 9: 9.1i, j; 9.2 i, j; 9.3 i, k NONPF NP Core Competencies: 1: NP 1.1h; NP 1.2 k, m; NP 1.3 f, j, h 2: NP 2.1 j, g; NP 2.2 k, n; NP 2.4 h, i; NP 2.5 k, l, m, n, o 7: NP 7.2 m 9: NP 9.1 m, n; NP 9.2 n; NP 9.3 p References: AAP Section on Emergency Medicine & Canadian Association of Emergency Physicians. (2022). Five things physicians and patients should question. Retrieved from https://downloads.aap.org/AAP/PDF/Choosing%20Wisely/CWEmergencyMedicine.pdf AAP Section on Gastroenterology, Hepatology, and Nutrition. (2023). Five things physicians and patients should question. https://downloads.aap.org/AAP/PDF/Choosing%20Wisely/CWGastroenterology.pdf AAP Section on Urology. (2022). Five things physicians and patients should question. Retrieved from https://downloads.aap.org/AAP/PDF/Choosing%20Wisely/CWUrology.pdf Daniel, M., Szymanik-Grzelak, H., Sierdziński, J., Podsiadły, E., Kowalewska-Młot, M., & Pańczyk-Tomaszewska, M. (2023). Epidemiology and Risk Factors of UTIs in Children-A Single-Center Observation. Journal of personalized medicine, 13(1), 138. https://doi.org/10.3390/jpm13010138 McMullen, P.C., Zangaro, G., Selzer, C., Williams, H. (2026). Nurse Practitioner Claims and the National Practitioner Data Bank: Trends, Analysis, and Implications for Nurse Practitioner Education and Practice. Journal for Nurse Practitioners, 22(1), p. 105569, https://doi-org.proxy.lib.duke.edu/10.1016/j.nurpra.2025.105569 Tabbers, M. M., DiLorenzo, C., Berger, M. Y., Faure, C., Langendam, M. W., Nurko, S., Staiano, A., Vandenplas, Y., Benninga, M. A., European Society for Pediatric Gastroenterology, Hepatology, and Nutrition, & North American Society for Pediatric Gastroenterology (2014). Evaluation and treatment of functional constipation in infants and children: evidence-based recommendations from ESPGHAN and NASPGHAN. Journal of pediatric gastroenterology and nutrition, 58(2), 258–274. https://doi.org/10.1097/MPG.0000000000000266 UCSF Benioff Children's Hospitals. (n.d.). Constipation & urologic problems. https://www.ucsfbenioffchildrens.org/conditions/constipation-and-urologic-problems Vaughan, D. (2015). The Challenger Launch Decision: Risky Technology, Deviance, and Culture at NASA. University of Chicago Press. DOI: 10.7208/chicago/9780226346960.001.0001 Wilbanks, Bryan A. PhD, DNP, CRNA. Evaluation of Methods to Measure Production Pressure: A Literature Review. Journal of Nursing Care Quality 35(2):p E14-E19, April/June 2020. | DOI: 10.1097/NCQ.0000000000000411

Nutrient Deficiencies and Their Link to Alzheimer's Disease and Diabetes Risk in Night Owls: Nutritionist Leyla Muedin discusses research findings linking nutrient deficiencies to Alzheimer's disease and how diet and supplementation can play a crucial role in prevention. She highlights the importance of antioxidants like lutein, zeaxanthin, and lycopene for brain health and their potential to reduce Alzheimer's risk. Leyla also delves into the connection between evening chronotypes ('night owls') and an increased risk of diabetes, emphasizing the role of lifestyle factors and offering suggestions for healthier sleep habits. She encourages listeners to maintain a diet rich in carotenoids for better cognition and eye health, and to adjust sleeping patterns for overall well-being.

Dr. Don and Professor Ben talk about the risks of feeding recalled sealed Byheart baby formula to a baby. Fedica text: Dr. Don - risky ☣️ Professor Ben - risky ☣️ ByHeart recalls organic baby formula amid infant botulism outbreak | AP News Infant Botulism Outbreak Linked to Infant Formula, November 2025 | Botulism | CDC Seven-Year Case-Control Study in California of Risk Factors for Infant Botulism - ScienceDirect Elevated incidence of infant botulism in a 17-county area of the Mid-Atlantic region in the United States, 2000–2019, including association with soil types | Applied and Environmental Microbiology Tyndallization - Wikipedia Outbreak Investigation of Infant Botulism: Infant Formula (November 2025) | FDA

Click to Text Thoughts on Today's EpisodePelvic floor issues often worsen dramatically during perimenopause and menopause. By age 50, estrogen can drop by 50%, which decreases collagen production—the building block of pelvic floor tissue. Today you'll hear an informative conversation with PT Christina Walsh from Tighten Your Tinkler about pelvic floor health, particularly for women in perimenopause and menopause.  Main points discussed:1.  Why Pelvic Floor Issues Worsen with Age 2.  Dysfunction vs. Prolapse 3.  Medical Care Challenges 4.  Birth and Risk Factors 5.  Exercise Recommendations 5.  Practical Tips to Start Today LINKSEpisodes Featuring Christina and Jenn of Tighten Your Tinkler:These two common exercise moves aren't helping your pee issues. Here's why. Season 15 Episode 9The surprising reason for your back and hip pain (not visible on x-ray) Season 13 Episode 13Episodes MentionedShould I wear a weighted vestFiber and menopauseResourcesTake the 5-minute quizhttps://www.tightenyourtinkler.com/backandhipreliefUse code GRACEDHEALTH for $50 off the Tighten Your Tinkler Signature ProgramConnect with Christina and Tighten Your Tinklerhttps://www.tightenyourtinkler.com/Instagram: @tighten.your.tinklerYouTubeMy latest recommended ways to nourish and move your body, mind and spirit: Nourished Notes Bi-Weekly Newsletter Be Strong and Vibrant! Online Strength Training Course for Christian Women in Perimenopause and Beyond 30+ Non-Gym Ways to Improve Your Health (free download)Connect with Amy: GracedHealth.com Instagram: @GracedHealthYouTube: @AmyConnell

Send us a textIn this episode of PT Snacks podcast, host Kasey dives deep into the topic of osteoporosis, exploring its definition, risk factors, prevalence, and the crucial role physical therapists play in managing it. Kasey explains what osteoporosis is, the impact it has on patients, and provides evidence-based strategies for addressing it through exercise. Learn about the importance of resistance training, balance, and impact exercises, and get practical tips for helping patients with different risk levels. Tune in to empower your practice and support your patients effectively!00:00 Welcome to PT Snacks Podcast01:10 Understanding Osteoporosis03:53 Risk Factors and Demographics07:38 Exercise and Treatment Strategies14:09 Categorizing Patients by Risk17:02 Additional Resources and ConclusionSupport the showNeed CEUs? Unlock unlimited online courses, live webinars, and certification-prep programs with MedBridge. You'll get: Thousands of accredited, evidence-based courses across multiple specialties (PT, OT, AT, SLP) that count for state-license CEUs. Access anytime, from your office, phone, or home—perfect for busy clinicians. One annual subscription, no per-course fee. Special offers: Use code PTSNACKSPODCAST at checkout and save over $100. Students use code PTSNACKSPODCASTSTUDENT for a discounted annual plan. Studying for the NPTE? Check out PT Final Exam — they've helped thousands of students pass with confidence. Use code PTSnacks at checkout for a discount. Stay Connected! Follow so you never miss an episode. Send your questions via email to ptsnackspodcast@gmail.com Join the email list HERE Support the Show:Shar...

In the December 2, 2025 episode of JACC This Week, Editor-in-Chief Harlan M. Krumholz, MD, SM, introduces the Spotlight Issue, anchored by the manuscript "Global, Regional, and National Burden of Cardiovascular Disease and Risk Factors in 204 Countries and Territories, 1990–2023." Listen here as he reviews the issue and gives listeners perspective on the issue as a whole, which contains 19 viewpoints providing perspectives from experts around the world, plus his editor's page, aligned with a talk given at the UN with JACC Editor Emeritus Valentin Fuster, MD, and author Gregory A. Roth, MD. Other perspectives include: CVD in Sub-Saharan Africa; access to essential medicines and technologies; confronting inequities in pediatric cardiac care; and perspectives from Japan, Canada, the Middle East & North Africa, South America, Pakistan, and many others.  Listen to the podcast and then check out the full issue online here: https://www.jacc.org/toc/jacc/86/22.

This recording features audio versions of the December 2025 Journal of Vascular and Interventional Radiology (JVIR) abstracts:ArticlesAssociation between Age of Kidney Transplant and Hemorrhagic Adverse Events Following Transplant Kidney Biopsy (Read)A Prospective Single-Arm Trial of Genicular Artery Embolization for Symptomatic Knee Osteoarthritis: Clinical and Biomarker Outcomes (Read)Transcatheter Arterial Embolization for Colonic Diverticular Bleeding: Outcomes and Risk Factors for Rebleeding (Read)Simultaneous Portal and Hepatic Vein Embolization versus Portal Vein Embolization Only in Patients with Hepatocellular Carcinoma: A Retrospective Review of Safety and Effectiveness (Read)Pulmonary Toxicity of Ethiodized Oil in the Venous Circulation in Mice: Radiological Findings and Pathological Correlation (Read)JVIR and SIR thank all those who helped record this episode. To sign up to help with future episodes, please contact our outreach coordinator at millennie.chen.jvir@gmail.com.HostSonya Choe, University of California Riverside School of MedicineAudio EditorDaniel Roh, Loma Linda University School of MedicineOutreach CoordinatorMillennie Chen, University of California Riverside School of MedicineAbstract Readers:Shobhit Chamoli, Armed Forces Medical CollegeEmily Jagenberg,  Oakland University. William Beaumont School of Medicine Morgan Smeltzer, Western Michigan University Homer Stryker School of MedicineThanmayi Parasu, University of Texas Medical BranchTiffany Nakla, Touro University Nevada College of Osteopathic Medicine, Nevada Support the show

Nutritionist Leyla Muedin focuses on a new perspective in Alzheimer's research, particularly the role of microglial cells. She reveals insights from integrative neurologist Dr. David Perlmutter's presentation at the Integrative Healthcare Symposium, emphasizing the significance of microglial cells in Alzheimer's disease. The discussion highlights the traditional focus on beta amyloid plaques and introduces the importance of shifting from the M1 pro-inflammatory phenotype to the M2 anti-inflammatory phenotype of microglial cells. Dr. Perlmutter advocates for addressing systemic metabolic and inflammatory issues, pointing out factors like poor diet, lack of sleep, and high blood sugar, which are crucial in preventing Alzheimer's. The episode delves into lifestyle interventions such as ketogenic diets, fasting, and nutritional impacts to manage and potentially reverse the detrimental shift in microglial behavior.

Closing the Gap: Understanding Gender Disparities in Bladder Cancer Care, hosted by Martha K. Terris, MD, FACS, is a limited series spotlighting unique considerations for bladder cancer diagnosis and treatment among women. Dr Terris is department chair and a professor in the Department of Urology, the Witherington Distinguished Chair in Urology, and co-director of the Cancer Center at the Medical College of Georgia at Augusta University. In the final part of this 3-part series, Dr Terris discussed how the early diagnosis of bladder cancer presents a significant challenge, particularly in female patients, who are frequently diagnosed at a later stage of the disease and subsequently respond less favorably to treatment modalities. A crucial component of early detection is the rigorous evaluation of hematuria, she emphasized. Microhematuria is defined strictly by microscopy. Reliance solely on a dipstick test is insufficient; any positive dipstick result necessitates a microscopic examination, she explained. Furthermore, patients currently receiving anticoagulation therapy do not bypass the standard workup, she noted. If hematuria is identified alongside a urinary tract infection or gynecological issue, the urine should be rechecked once the co-existing problem has cleared, she advised. Risk assessment must consider both common and less-recognized factors, particularly in women, according to Terris. Standard risks include exposure to cyclophosphamide or ifosfamide, Lynch syndrome, chronic indwelling Foley catheters, benzene/aromatic amine exposure, and smoking, she added. However, uro-oncologists must actively assess female patients for occupational exposures not traditionally associated with bladder cancer, she said. Patients presenting with microhematuria should be stratified into low-, intermediate-, or high-risk groups, Terris continued. The gold standard evaluation for high-risk patients is a cystoscopy and CT urogram, she reported. The CT urogram involves cross-sectional imaging of the abdomen and pelvis with and without contrast, incorporating delayed images to optimally visualize the renal pelvis and ureters for potential filling defects, she noted. If patients cannot tolerate contrast, an MR urogram is the primary alternative, she stated. If neither CT nor MR urogram can be performed, the default workup is non-contrast CT combined with cystoscopy and retrograde pyelograms, although this requires general anesthesia, she explained. Given that women are often diagnosed with bladder cancer late and face poor outcomes with advanced disease, maintaining a heightened awareness and low threshold for investigation is critical, Terris concluded.

Send us a textThis episode features Dr. Giulia Lima (Boston Children's Hospital), a CHNC Mentored Fellow, discussing risk factors for morbidity and mortality among preterm infants with congenital heart disease (CHD) using data from over 11,000 NICU admissions. Surprisingly, older gestational age did not predict improved survival once infants survived beyond three days. Major mortality predictors included surgical NEC, bloodstream infection, trisomy 21, airway anomalies, and compromised systemic output lesions. Multiple gestation appeared protective, though reasons remain unclear. Dr. Lima highlights the importance of standardized prenatal steroids, care coordination, and exploring socioeconomic and ethnic disparities to improve outcomes in this uniquely vulnerable CHD population.Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

Todd Love, Psy.D., JD, explores the science linking ADHD and behavioral addictions — from gambling and pornography to gaming and social media. He explains the toll these behaviors take on daily life and highlights strategies that promote recovery. Behavioral Addictions and ADHD: Resources Free Download: Your ADHD Dopamine Menu Template Read: ADHD and Addiction: The Truth About Substance Abuse Read: Video Game Addiction: Signs, Risk Factors, and ADHD Links Read: Never Enough? Why ADHD Brains Crave Stimulation Access the video and slides for podcast episode #583 here: https://www.additudemag.com/webinar/behavioral-addiction-adhd/ Thank you for listening to ADDitude's ADHD Experts podcast. Please consider subscribing to the magazine (additu.de/subscribe) to support our mission of providing ADHD education and support.

The McCullough Report with Dr. Peter McCullough – A comprehensive new report from the McCullough Foundation reveals strong evidence linking early childhood vaccination to increased autism risk. Drawing on over a hundred studies, researchers challenge long-held assumptions about vaccine safety and call for urgent public health reforms, including suspension of vaccine mandates and a reexamination of the National Childhood...

The McCullough Report with Dr. Peter McCullough – A comprehensive new report from the McCullough Foundation reveals strong evidence linking early childhood vaccination to increased autism risk. Drawing on over a hundred studies, researchers challenge long-held assumptions about vaccine safety and call for urgent public health reforms, including suspension of vaccine mandates and a reexamination of the National Childhood...

Contributor: Meghan Hurley, MD Educational Pearls: 1. Initial Assessment Start with a physical examination: Determine if the bleed is anterior or posterior. Perform a primary survey: assess airway, breathing, and circulation (ABCs). Airway compromise = intubation immediately. If the patient is stable, have them blow out any clots, then re-examine the nares. 2. Topical Medications Anesthetics: provide local anesthesia and pain relief. Lidocaine Tetracaine Vasoconstrictors: reduce bleeding. LET (Lidocaine, Epinephrine, Tetracaine) is ideal because it provides anesthesia and vasoconstriction. Cocaine pledgets (less common). Tranexamic acid (TXA). Oxymetazoline (Afrin). Cautery (Chemical): If an anterior bleed is visualized, silver nitrate can be applied for cauterization 3. Technique Tips Use a nasal speculum. Spread up and down rather than side to side to avoid injury to the septum. Place LET-soaked gauze in the nares. Apply a nasal clamp for ~15 minutes to compress the vessels. Note that pledgets may cause upper lip numbness 4. Reassessment After 15 minutes, remove materials and inspect for a source of bleeding. If still bleeding and a source is identified, cauterize the site. Observe for 15 minutes to monitor for recurrence of bleeding. 5. Packing If the above measures fail to control bleeding: Anterior packing: Nasal tampon (Merocel) Convenient for outpatient removal. Balloon device Inflate the anterior balloon for compression. Posterior packing:  More complex, should consult ENT for additional assistance. 6. Disposition & Follow-Up Although rare, toxic shock syndrome is a possible complication of nasal packing. Antibiotic prophylaxis is controversial, but may be considered in high-risk patients. Outpatient follow-up if stable: Tampon: The patient can remove it at home. Balloon: Return to ED for removal. 7. Risk Factors for Epistaxis & Prevention Deviated septum, dry environments, and anticoagulant use Advise on humidifier use, nasal saline, and medication review to minimize future episodes. References: Tunkel DE, Anne S, Payne SC, et al. Clinical Practice Guideline: Nosebleed (Epistaxis). Otolaryngology–Head and Neck Surgery. 2020;162(1_suppl):S1-S38. doi:10.1177/0194599819890327   Summarized by Ashley Lyons, OMS3 | Edited by Ashley Lyons and Jorge Chalit, OMS4 Donate: https://emergencymedicalminute.org/donate/  

Summary In this episode, Andy talks with Amireh Amirmazaheri, CEO of PMO Solutions and a leading voice in the global PMO community. From growing up in Iran during a time of war to building a respected consultancy in Australia, Amireh shares how resilience and curiosity shaped her approach to leadership and enabling project success. You'll hear how PMOs have evolved from administrative hubs to strategic influencers, what it means to truly "speak the language of executives," and how to recognize when a PMO is at risk of drifting into irrelevance. We also explore how AI is transforming the work of PMOs and what leaders can do to stay ahead of the curve. Plus, Amireh offers practical advice on leading as a woman in project management and applying PMO principles at home as a parent. If you're looking for insights on elevating PMO impact, executive communication, and leading through change, this episode is for you! Sound Bites "Limitations aren't always bad. They push us into the creativity zone." "Executives don't want red or amber. They want to know where the ship is heading." "When PMOs chase BAU firefighting, they lose their strategic brain." "If PMOs stay educated and ahead of the game, they can influence the AI journey." "It's okay to cry. Then think, learn, and lead." "Um, should I tell you that my little one has a kanban board?" Chapters 00:00 Introduction 01:31 Start of Interview 01:42 Early Life in Iran and Resilience 12:56 Lessons About Enablement 15:02 How PMOs Have Changed 18:55 Speaking the Language of Executives 21:22 Failure Clues and PMO Drift 25:11 Sponsorship as a Risk Factor 26:08 Using AI and Its Near-Term Impact on PMOs 32:25 Leading as a Woman 37:44 Applying PM and PMO Ideas at Home 40:22 PMO Global Alliance Overview 42:15 End of Interview 42:50 Andy Comments After the Interview 46:22 Outtakes Learn More You can learn more about Amireh and her work at PMOSol.com, or connect with her on LinkedIn. For more learning on this topic, check out: Episode 436 with Laura Barnard, about the IMPACT Engine Episode 429 with Bill Dow, about PMO insights Episode 187 with Peter Taylor, Bill Dow, and others, about the State of PMOs Level Up Your AI Skills Join other listeners from around the world who are taking our AI Made Simple course to prepare for an AI-infused future. Just go to ai.PeopleAndProjectsPodcast.com. Thanks! Pass the PMP Exam This Year If you or someone you know is thinking about getting PMP certified, we've put together a helpful guide called The 5 Best Resources to Help You Pass the PMP Exam on Your First Try. We've helped thousands of people earn their certification, and we'd love to help you, too. It's totally free, and it's a great way to get a head start. Just go to 5BestResources.PeopleAndProjectsPodcast.com to grab your copy. I'd love to help you get your PMP! Join Us for LEAD52 I know you want to be a more confident leader—that's why you listen to this podcast. LEAD52 is a global community of people like you who are committed to transforming their ability to lead and deliver. It's 52 weeks of leadership learning, delivered right to your inbox, taking less than 5 minutes a week. And it's all for free. Learn more and sign up at GetLEAD52.com. Thanks! Thank you for joining me for this episode of The People and Projects Podcast! Talent Triangle: Ways of Working Topics: PMOs, Executive Communication, Leadership, AI in Projects, Change Management, Strategic Thinking, Women in Leadership, Organizational Influence, Resilience, Stakeholder Engagement, Career Growth, Continuous Improvement The following music was used for this episode: Music: Brooklyn Nights by Tim Kulig License (CC BY 4.0): https://filmmusic.io/standard-license Music: Tuesday by Sascha Ende License (CC BY 4.0): https://filmmusic.io/standard-license