Podcasts about science new york

Man kennt es... Vor der Klausur steht man vor einem Berg an Fakten, der unbezwingbar scheint. Wie gehe ich das Lernen an, sodass der Inhalt bestenfalls sogar langfristig in meinem Hirn hängen bleibt? Um euch den aktuellsten Stand der Lernforschung zu liefern, haben wir Michail aus Hamburg eingeladen! Er ist selbst Medi und beschäftigt sich mit der studentischen Forschungsgruppe ME-Learn mit diversen Lernmethoden. Wir liefern euch in dieser Folge wertvolle, evidenzbasierte Tipps für eure nächste Klausurenphase. Wir reden auch darüber, wie Dank Effizienz noch viel Zeit für Hobbies bleibt

In this episode of the Epigenetics Podcast, we talked with Carl Wu from John's Hopkins University about his work on nucleosome remodeling, histone variants, and the role of single-molecule imaging in gene regulation. Our discussion starts with Carl Wu sharing his first significant milestones, a paper in "Cell" and the serendipitous discovery of DNA hypersensitive sites, which transformed our understanding of chromatin accessibility and its implications for gene regulation. As we delve into Dr. Wu's specific areas of research, he elaborates on the biochemistry of nucleosome remodeling and the intricate role of chromatin remodeling enzymes like NURF. We discuss how these enzymes employ ATP hydrolysis to reposition nucleosomes, making DNA accessible for transcription. He then explains the collaborative relationship between chromatin remodelers and transcription factors, showcasing the fascinating interplay that governs gene expression and regulatory mechanisms. The conversation takes a deeper turn as we explore Carl Wu's groundbreaking studies on histone variants, particularly H2AZ. He elucidates the role of SWR1 in facilitating the exchange between H2A and H2AZ in nucleosome arrays. The high-resolution structural insights garnered from recent studies reveal how the enzyme mediates histone eviction and insertion with remarkable precision, providing a clearer picture of chromatin dynamics at a molecular level.   References Wu, C., Bingham, P. M., Livak, K. J., Holmgren, R., & Elgin, S. C. (1979). The chromatin structure of specific genes: I. Evidence for higher order domains of defined DNA sequence. Cell, 16(4), 797–806. https://doi.org/10.1016/0092-8674(79)90095-3 Wu, C., Wong, Y. C., & Elgin, S. C. (1979). The chromatin structure of specific genes: II. Disruption of chromatin structure during gene activity. Cell, 16(4), 807–814. https://doi.org/10.1016/0092-8674(79)90096-5 Wu C. (1980). The 5' ends of Drosophila heat shock genes in chromatin are hypersensitive to DNase I. Nature, 286(5776), 854–860. https://doi.org/10.1038/286854a0 Wu, C., Wilson, S., Walker, B., Dawid, I., Paisley, T., Zimarino, V., & Ueda, H. (1987). Purification and properties of Drosophila heat shock activator protein. Science (New York, N.Y.), 238(4831), 1247–1253. https://doi.org/10.1126/science.3685975 Mizuguchi, G., Shen, X., Landry, J., Wu, W. H., Sen, S., & Wu, C. (2004). ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex. Science (New York, N.Y.), 303(5656), 343–348. https://doi.org/10.1126/science.1090701 Kim, J. M., Visanpattanasin, P., Jou, V., Liu, S., Tang, X., Zheng, Q., Li, K. Y., Snedeker, J., Lavis, L. D., Lionnet, T., & Wu, C. (2021). Single-molecule imaging of chromatin remodelers reveals role of ATPase in promoting fast kinetics of target search and dissociation from chromatin. eLife, 10, e69387. https://doi.org/10.7554/eLife.69387   Related Episodes Multiple challenges of ATAC-Seq, Points to Consider (Yuan Xue) Pioneer Transcription Factors and Their Influence on Chromatin Structure (Ken Zaret) ATAC-Seq, scATAC-Seq and Chromatin Dynamics in Single-Cells (Jason Buenrostro)   Contact Epigenetics Podcast on X Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Epigenetics Podcast on Threads Active Motif on X Active Motif on LinkedIn Email: podcast@activemotif.com

In this episode of the Epigenetics Podcast, we talked with Karine Le Roch from the University of California at Riverside about her work on malaria chromatin structure and its transcriptional regulation. In this Interview Dr. Le Roch discusses her investigation of post-transcriptional controls and nucleosome positioning in Plasmodium falciparum, employing next-generation sequencing and chromatin profiling methods. Karin emphasizes how these methodologies contribute to a comprehensive understanding of gene regulation beyond mere transcription initiation, emphasizing the significance of mRNA binding proteins and their role in stabilizing gene transcripts for translation. This exploration of the interaction between chromatin structure, transcriptional dynamics, and post-transcriptional regulation reveals a multidimensional perspective of gene expression. Transitioning to her lab's focus on high-throughput genomic technologies, we discuss how Karin and her team are uncovering conserved and species-specific genomic organization principles within various Plasmodium species. By generating 3D genomic models through Hi-C experiments, she describes how they have identified patterns that underline the parasite's immune evasion strategies. In particular, we learn how genes involved in antigenic variation are controlled through intricate epigenetic mechanisms, illuminating the pathways that allow these parasites to elude host immune responses.   References Le Roch, K. G., Zhou, Y., Blair, P. L., Grainger, M., Moch, J. K., Haynes, J. D., De La Vega, P., Holder, A. A., Batalov, S., Carucci, D. J., & Winzeler, E. A. (2003). Discovery of gene function by expression profiling of the malaria parasite life cycle. Science (New York, N.Y.), 301(5639), 1503–1508. https://doi.org/10.1126/science.1087025 Ponts, N., Harris, E. Y., Prudhomme, J., Wick, I., Eckhardt-Ludka, C., Hicks, G. R., Hardiman, G., Lonardi, S., & Le Roch, K. G. (2010). Nucleosome landscape and control of transcription in the human malaria parasite. Genome research, 20(2), 228–238. https://doi.org/10.1101/gr.101063.109 Bunnik, E. M., Cook, K. B., Varoquaux, N., Batugedara, G., Prudhomme, J., Cort, A., Shi, L., Andolina, C., Ross, L. S., Brady, D., Fidock, D. A., Nosten, F., Tewari, R., Sinnis, P., Ay, F., Vert, J. P., Noble, W. S., & Le Roch, K. G. (2018). Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages. Nature communications, 9(1), 1910. https://doi.org/10.1038/s41467-018-04295-5   Related Episodes Epigenetics in Human Malaria Parasites (Elena Gómez-Diaz)   Contact Epigenetics Podcast on X Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Epigenetics Podcast on Threads Active Motif on X Active Motif on LinkedIn Email: podcast@activemotif.com

Dr Mansi Srivastava of Harvard University joins Chris and Courtney to talk about her research on regeneration throughout evolution. ----------------------------------------------------------------- Dr. Srivastava's research focuses on understanding the evolution of animal development and regeneration. Her group utilizes the three-banded panther worm, Hofstenia miamia, which Dr. Srivastava has developed as a new acoel model system. Acoels represent the sister-group to all animals with bilateral symmetry, which allows the study of genetic mechanisms that span 550 million years of animal evolution. Current projects in her lab range from identifying gene regulatory networks for regeneration to determining the embryonic origins of pluripotent stem cells to understanding the origins of bilaterian nervous systems. Her lab website can be found here: www.srivastavalab.org/ The following are citations for the articles mentioned on today's show: Srivastava M. (2021). Beyond Casual Resemblance: Rigorous Frameworks for Comparing Regeneration Across Species. Annual review of cell and developmental biology, 37, 415–440. https://doi.org/10.1146/annurev-cellbio-120319-114716 Gehrke, A. R., Neverett, E., Luo, Y. J., Brandt, A., Ricci, L., Hulett, R. E., Gompers, A., Ruby, J. G., Rokhsar, D. S., Reddien, P. W., & Srivastava, M. (2019). Acoel genome reveals the regulatory landscape of whole-body regeneration. Science (New York, N.Y.), 363(6432), eaau6173. https://doi.org/10.1126/science.aau6173 Contact the Sausage of Science Podcast and Human Biology Association: Facebook: www.facebook.com/groups/humanbiologyassociation Website: humbio.org/, Twitter: @HumBioAssoc Chris Lynn, Host Website: cdlynn.people.ua.edu/, E-mail: cdlynn@ua.edu, Twitter:@Chris_Ly Courtney Manthey, Guest-Co-Host, Website: holylaetoli.com/ E-mail: cpierce4@uccs.edu, Twitter: @HolyLaetoli Anahi Ruderman, SoS Co-Producer, HBA Junior Fellow E-mail: aniruderman@gmail.com

היה לנו את הכבוד לארח את פרופ׳ אלדר שפיר!אלדר שפיר הוא פרופסור לפסיכולוגיה ולמדיניות באוניברסיטת פרינסטון, ומנהל המרכז למדעי ההתנהגות ומדיניות על שם טריזמן-כהנמן. כמו כן, הוא מהמייסדים של חברת Ideas42.פרופ׳ שפיר תיאר את תופעת המחסור הפסיכולוגי ולפיה ישנם דפוסים משותפים בקרב אנשים עניים, אנשים בודדים ואנשים עמוסים. הוא שיתף במחקרים שלו המתמקדים בהשפעות של עוני על IQ, קבלת החלטות ויכולות קוגניטיביות נוספות. הוא גם סיפר על העבודה לצדו של עמוס טברסקי ז״ל.שלושה נושאים מסקרנים שדיברנו עליהם עם פרופ׳ שפיר במהלך הפרק:✅   מה זאת הטיית עור הפיל (Thick Skin Bias)?✅   איך צמצום חדרי ניתוח בבית חולים דווקא שיפר את ההתנהלות?✅   למה כדאי לקבוע ביומן פגישות עם עצמך?~~~

In this episode of the Epigenetics Podcast, we talked with James Hackett from the EMBL in Rome about his work on epigenetic mechanisms in genome regulation and developmental programming. One of James Hackett's significant studies focused on DNA methylation and genome defense mechanisms in the germline, exploring the role of chromatin modifications in mammalian gene regulation. He delves into investigating the erasure of DNA methylation in the germline, highlighting the key role of the TET-enzymes in demethylation processes. Dr. Hackett shares insights from his research on pluripotent stem cells, where he mapped genome-wide DNA methylation and hydroxymethylation in different pluripotent states. He discusses the impact of extrinsic conditions on pluripotent states and the biases observed in lineage preferences. Furthermore, the discussion delves into the development of a CRISPR screening tool to study cell fate transitions, particularly focusing on the genetic factors contributing to germline specification. He also talks about his work on epigenetic inheritance, highlighting the importance of precise perturbations in understanding chromatin modifications and their functional implications. In a recent study, the Hackett lab focuses on systematic epigenome editing to investigate the context-dependent functions of chromatin modifications. We hear about this work, and the complexity of interactions between chromatin marks, DNA sequences, and transcription factors, shedding light on the nuanced effects of various chromatin modifications on gene expression.   References Hackett JA, Reddington JP, Nestor CE, et al. Promoter DNA methylation couples genome-defence mechanisms to epigenetic reprogramming in the mouse germline. Development (Cambridge, England). 2012 Oct;139(19):3623-3632. DOI: 10.1242/dev.081661. PMID: 22949617; PMCID: PMC3436114. Hackett JA, Sengupta R, Zylicz JJ, et al. Germline DNA demethylation dynamics and imprint erasure through 5-hydroxymethylcytosine. Science (New York, N.Y.). 2013 Jan;339(6118):448-452. DOI: 10.1126/science.1229277. PMID: 23223451; PMCID: PMC3847602. Hackett JA, Kobayashi T, Dietmann S, Surani MA. Activation of Lineage Regulators and Transposable Elements across a Pluripotent Spectrum. Stem Cell Reports. 2017 Jun;8(6):1645-1658. DOI: 10.1016/j.stemcr.2017.05.014. PMID: 28591649; PMCID: PMC5470235. Hackett JA, Huang Y, Günesdogan U, et al. Tracing the transitions from pluripotency to germ cell fate with CRISPR screening. Nature Communications. 2018 Oct;9(1):4292. DOI: 10.1038/s41467-018-06230-0. PMID: 30327475; PMCID: PMC6191455.   Related Episodes Epigenetic and Metabolic Regulation of Early Development (Jan Żylicz) H3K79 Methylation, DOT1L, and FOXG1 in Neural Development (Tanja Vogel) The Impact of Chromatin Modifiers on Disease Development and Progression (Capucine van Rechem)     Contact Epigenetics Podcast on X Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Epigenetics Podcast on Threads Active Motif on X Active Motif on LinkedIn Email: podcast@activemotif.com

In this episode of the Epigenetics Podcast, we talked with Lothar Schermelleh from the University of Oxford about his work on advanced optical imaging in 3D nuclear organisation.  The interview starts by Lothar Schermelleh sharing his groundbreaking work in understanding chromatin organization using super-resolution microscopy techniques. He then delves into his past experiments, including his publication on imaging chromatin domains and X chromosome inactivation. His work showcases the power of structured illumination microscopy in overcoming diffraction limits, revealing insights into nuclear organization and regulation. Lothar also discusses refining methods for labeling chromosome territories and replication domains, as well as exploring structural and functional nuclear organization using advanced microscopy techniques. They touch on the potential of AI in microscopy, the importance of quality control in imaging, and Lothar's grant proposal for developing artifact-free, super-resolution imaging under cryo conditions with adaptive optics. The conversation emphasizes the intersection of technology development and biological applications, highlighting the importance of addressing specific biological questions through innovative imaging approaches.    References Schermelleh, L., Carlton, P. M., Haase, S., Shao, L., Winoto, L., Kner, P., Burke, B., Cardoso, M. C., Agard, D. A., Gustafsson, M. G., Leonhardt, H., & Sedat, J. W. (2008). Subdiffraction multicolor imaging of the nuclear periphery with 3D structured illumination microscopy. Science (New York, N.Y.), 320(5881), 1332–1336. https://doi.org/10.1126/science.1156947 Schermelleh, L., Heintzmann, R., & Leonhardt, H. (2010). A guide to super-resolution fluorescence microscopy. The Journal of cell biology, 190(2), 165–175. https://doi.org/10.1083/jcb.201002018 Smeets, D., Markaki, Y., Schmid, V. J., Kraus, F., Tattermusch, A., Cerase, A., Sterr, M., Fiedler, S., Demmerle, J., Popken, J., Leonhardt, H., Brockdorff, N., Cremer, T., Schermelleh, L., & Cremer, M. (2014). Three-dimensional super-resolution microscopy of the inactive X chromosome territory reveals a collapse of its active nuclear compartment harboring distinct Xist RNA foci. Epigenetics & chromatin, 7, 8. https://doi.org/10.1186/1756-8935-7-8 Ball, G., Demmerle, J., Kaufmann, R., Davis, I., Dobbie, I. M., & Schermelleh, L. (2015). SIMcheck: a Toolbox for Successful Super-resolution Structured Illumination Microscopy. Scientific reports, 5, 15915. https://doi.org/10.1038/srep15915   Related Episodes Long-Range Transcriptional Control by 3D Chromosome Structure (Luca Giorgetti) Analysis of 3D Chromatin Structure Using Super-Resolution Imaging (Alistair Boettiger)   Contact Epigenetics Podcast on X Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Epigenetics Podcast on Threads Active Motif on X Active Motif on LinkedIn Email: podcast@activemotif.com

In this episode of the Epigenetics Podcast, we talked with Nadav Ahituv from University of California, San Francisco about his work on mutations of gene regulatory elements in human disease. Using massively parallel experiments, his lab revolutionized functional genomics by studying the impact of transcription factor binding sites on gene expression. His groundbreaking technology deciphered the regulatory language of gene expression by exploring transcription factor combinations, spacing, and orientation. By delving into the influence of DNA shape and gene topology, Nadav Ahituv's research provides a comprehensive understanding of gene regulation at the molecular level, shedding light on the complexity of genetic interactions. The conversation delves into specific cases involving enhancers, gene sequencing, and 3D genomic structure, highlighting the impact of critical elements such as CTCF sites on gene expression. Discussions of haploid insufficiency and its implications for human health, using CRISPR technology to enhance gene expression, offer new possibilities for treating genetic diseases. Explorations of leptin-responsive regulatory elements in the hypothalamus and liver-associated transcription factors provide insights into metabolic regulation and gene expression networks in different tissues. The episode also explores the epigenomic landscape, the evolution of methods from bulk approaches to single-cell analyses, and the role of AI and machine learning in deciphering complex genetic patterns. The conversation transitions to a unique study of bat embryonic development, dietary differences, and their implications for understanding wing development and metabolism in different bat species.   References Ahituv, N., Zhu, Y., Visel, A., Holt, A., Afzal, V., Pennacchio, L. A., & Rubin, E. M. (2007). Deletion of ultraconserved elements yields viable mice. PLoS biology, 5(9), e234. https://doi.org/10.1371/journal.pbio.0050234 Matharu, N., Rattanasopha, S., Tamura, S., Maliskova, L., Wang, Y., Bernard, A., Hardin, A., Eckalbar, W. L., Vaisse, C., & Ahituv, N. (2019). CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency. Science (New York, N.Y.), 363(6424), eaau0629. https://doi.org/10.1126/science.aau0629 Ushiki, A., Zhang, Y., Xiong, C., Zhao, J., Georgakopoulos-Soares, I., Kane, L., Jamieson, K., Bamshad, M. J., Nickerson, D. A., University of Washington Center for Mendelian Genomics, Shen, Y., Lettice, L. A., Silveira-Lucas, E. L., Petit, F., & Ahituv, N. (2021). Deletion of CTCF sites in the SHH locus alters enhancer-promoter interactions and leads to acheiropodia. Nature communications, 12(1), 2282. https://doi.org/10.1038/s41467-021-22470-z Georgakopoulos-Soares, I., Deng, C., Agarwal, V., Chan, C. S. Y., Zhao, J., Inoue, F., & Ahituv, N. (2023). Transcription factor binding site orientation and order are major drivers of gene regulatory activity. Nature communications, 14(1), 2333. https://doi.org/10.1038/s41467-023-37960-5 Gordon, W. E., Baek, S., Nguyen, H. P., Kuo, Y. M., Bradley, R., Fong, S. L., Kim, N., Galazyuk, A., Lee, I., Ingala, M. R., Simmons, N. B., Schountz, T., Cooper, L. N., Georgakopoulos-Soares, I., Hemberg, M., & Ahituv, N. (2024). Integrative single-cell characterization of a frugivorous and an insectivorous bat kidney and pancreas. Nature communications, 15(1), 12. https://doi.org/10.1038/s41467-023-44186-y   Related Episodes Ultraconserved Enhancers and Enhancer Redundancy (Diane Dickel) Enhancers and Chromatin Remodeling in Mammary Gland Development (Camila dos Santos) Enhancer-Promoter Interactions During Development (Yad Ghavi-Helm)   Contact Epigenetics Podcast on X Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Epigenetics Podcast on Threads Active Motif on X Active Motif on LinkedIn Email: podcast@activemotif.com

In this episode of the Epigenetics Podcast, we talked with Upasna Sharma from UC Santa Cruz about her work a number of interesting projects on H2A.Z and telomeres, the impact of paternal diet on offspring metabolism, and the role of small RNAs in sperm. In this interview Upasna Sharma discusses her work on the study of the paternal diet's impact on offspring metabolism. She reveals the discovery of small non-coding RNAs, particularly tRNA fragments, in mature mammalian sperm that may carry epigenetic information to the next generation. She explains the specific alterations in tRNA fragment levels in response to a low-protein diet and the connections found between tRNA fragments and metabolic status. Dr. Sharma further explains the degradation and stabilization of tRNA fragments in cells and the processes involved in their regulation. She shares their observation of tRNA fragment abundance in epididymal sperm, despite the sperm being transcriptionally silent at that time. This leads to a discussion on the role of the epididymis in the reprogramming of small RNA profiles and the transportation of tRNA fragments through extracellular vesicles. The conversation then shifts towards the potential mechanism of how environmental information could be transmitted to sperm and the observed changes in small RNAs in response to a low-protein diet. Dr. Sharma discusses the manipulation of small RNAs in embryos and mouse embryonic stem cells, revealing their role in regulating specific sets of genes during early development. However, the exact mechanisms that link these early changes to metabolic phenotypes are still being explored. References Sharma, U., Conine, C. C., Shea, J. M., Boskovic, A., Derr, A. G., Bing, X. Y., Belleannee, C., Kucukural, A., Serra, R. W., Sun, F., Song, L., Carone, B. R., Ricci, E. P., Li, X. Z., Fauquier, L., Moore, M. J., Sullivan, R., Mello, C. C., Garber, M., & Rando, O. J. (2016). Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals. Science (New York, N.Y.), 351(6271), 391–396. https://doi.org/10.1126/science.aad6780 Sharma, U., Sun, F., Conine, C. C., Reichholf, B., Kukreja, S., Herzog, V. A., Ameres, S. L., & Rando, O. J. (2018). Small RNAs Are Trafficked from the Epididymis to Developing Mammalian Sperm. Developmental cell, 46(4), 481–494.e6. https://doi.org/10.1016/j.devcel.2018.06.023 Rinaldi, V. D., Donnard, E., Gellatly, K., Rasmussen, M., Kucukural, A., Yukselen, O., Garber, M., Sharma, U., & Rando, O. J. (2020). An atlas of cell types in the mouse epididymis and vas deferens. eLife, 9, e55474. https://doi.org/10.7554/eLife.55474   Related Episodes The Epigenetics of Human Sperm Cells (Sarah Kimmins) Transgenerational Inheritance and Evolution of Epimutations (Peter Sarkies) The Role of Small RNAs in Transgenerational Inheritance in C. elegans (Oded Rechavi)   Contact Epigenetics Podcast on X Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Epigenetics Podcast on Threads Active Motif on X Active Motif on LinkedIn Email: podcast@activemotif.com

Wie helfen uns Gedanken an die Zukunft? Und wo können sie schaden? In dieser Podcastfolge sprechen Boris und Sinja über gute Vorsätze, Pläne und Träume – sowie die Wissenschaft dahinter. Wie häufig denken wir eigentlich an die Zukunft? Wann denken wir an die Zukunft? Und welche Konsequenzen haben diese Gedanken? Es wird sowohl die neurowissenschaftliche als auch die alltagspraktische Perspektive eingenommen. Wir erfahren, wie gut wir darin sind, die Zukunft in unseren Gedanken vorauszusehen und wie wir unsere Zukunftsgedanken positiv beeinflussen können.Wie gefällt dir Verstehen, fühlen, glücklich sein? Erzähle es uns hier. Hintergründe und Studien:Irish, M., & Piolino, P. (2016). Impaired capacity for prospection in the dementias–Theoretical and clinical implications. British Journal of Clinical Psychology, 55(1), 49-68. Link zur Studie Benoit, R. G., & Schacter, D. L. (2015). Specifying the core network supporting episodic simulation and episodic memory by activation likelihood estimation. Neuropsychologia, 75, 450-457. Link zur StudieKillingsworth, M. A., & Gilbert, D. T. (2010). A wandering mind is an unhappy mind. Science (New York, N.Y.), 330(6006), 932. Link zur StudieKawashima, I., Hinuma, T., & Tanaka, S. C. (2023). Ecological momentary assessment of mind-wandering: meta-analysis and systematic review. Scientific Reports, 13(1), 2873. Link zur StudieSmallwood, J., & Schooler, J. W. (2015). The science of mind wandering: Empirically navigating the stream of consciousness. Annual review of psychology, 66, 487-518. Link zur StudieMulholland, B., Goodall-Halliwell, I., Wallace, R., Chitiz, L., Mckeown, B., Rastan, A., ... & Smallwood, J. (2023). Patterns of ongoing thought in the real world. Consciousness and cognition, 114, 103530. Link zur StudieGirardeau, J. C., Sperduti, M., Blondé, P., & Piolino, P. (2022). Where is my mind…? The link between mind wandering and prospective memory. Brain Sciences, 12(9), 1139. Link zur StudieWilson, T. D., & Gilbert, D. T. (2005). Affective forecasting: Knowing what to want. Current directions in psychological science, 14(3), 131-134. Link zur Studie Levine, L. J., Lench, H. C., Kaplan, R. L., & Safer, M. A. (2012). Accuracy and artifact: Reexamining the intensity bias in affective forecasting. Journal of Personality and Social Psychology, 103(4), 584–605. Link zur StudieHsee, C. K., Hastie, R., & Chen, J. (2008). Hedonomics: Bridging decision research with happiness research. Perspectives on Psychological Science, 3(3), 224-243. Link zur StudieAdam Smith Zitat LinkMehr zu WOOP-ing LinkUnsere allgemeinen Datenschutzrichtlinien finden Sie unter https://art19.com/privacy. Die Datenschutzrichtlinien für Kalifornien sind unter https://art19.com/privacy#do-not-sell-my-info abrufbar.

En este episodio, resumo un artículo reciente (2023) de John Krakauer y Tamar Makin sobre la reorganización cortical. Es un artículo crítica a este concepto tan famoso y vanagloriado en neurociencia y se aportan datos que apoyan esta crítica mencionando estudios clásicos en animales y humanos. Estudios sobre ceguera congénita, experimentos en gatos y hurones, amputados y reorganización tras un ictus. Krakauer propone su definición y criterios de reorganización cortical y en base a eso refuta los estudios que afirman la reorganización. Referencias del episodio: 1. Makin, T. R., & Krakauer, J. W. (2023). Against cortical reorganisation. eLife, 12, e84716. https://doi.org/10.7554/eLife.84716 (https://pubmed.ncbi.nlm.nih.gov/37986628/). 2. Kilgard, M. P., & Merzenich, M. M. (1998). Cortical map reorganization enabled by nucleus basalis activity. Science (New York, N.Y.), 279(5357), 1714–1718. https://doi.org/10.1126/science.279.5357.1714 (https://pubmed.ncbi.nlm.nih.gov/9497289/). 3. Pascual-Leone, A., & Torres, F. (1993). Plasticity of the sensorimotor cortex representation of the reading finger in Braille readers. Brain : a journal of neurology, 116 ( Pt 1), 39–52. https://doi.org/10.1093/brain/116.1.39 (https://pubmed.ncbi.nlm.nih.gov/8453464/). 4. Nudo R. J. (2007). Postinfarct cortical plasticity and behavioral recovery. Stroke, 38(2 Suppl), 840–845. https://doi.org/10.1161/01.STR.0000247943.12887.d2 (https://pubmed.ncbi.nlm.nih.gov/17261749/). 5. Ramachandran, V. S., Stewart, M., & Rogers-Ramachandran, D. C. (1992). Perceptual correlates of massive cortical reorganization. Neuroreport, 3(7), 583–586. https://doi.org/10.1097/00001756-199207000-00009 (https://pubmed.ncbi.nlm.nih.gov/1421112/). 6. Wiesel, T. N., & Hubel, D. H. (1963). Single-cell responses in striate cortex of kittens deprived of vision in one eye. Journal of neurophysiology, 26, 1003–1017. https://doi.org/10.1152/jn.1963.26.6.1003 (https://pubmed.ncbi.nlm.nih.gov/14084161/).

In this episode of the Epigenetics Podcast, we talked with Maria Gambetta from the University of Lausanne about her work on the function of insulators in 3D genome folding. Maria Gambetta focuses on investigating 3D contact dynamics between enhancers and promoters, providing insights into tissue-specific gene activation. The team used capture-C to analyze dynamic looping events, emphasizing the significance of accessible chromatin peaks in enhancer-promoter interactions. Furthermore, they focused on gene insulation and CTCF's role in forming topologically associating domains in Drosophila. Hi-C analysis on CTCF mutants revealed the conservation of TAD boundary mechanisms, identifying CP-190 as a potential binding protein. Their findings on the loss of TAD boundaries in mutants and the role of transcription in TAD boundary formation are discussed as well as the function of CP190 and insulators in preventing interactions between promoters and enhancers. Their work challenges existing models of insulator function and seeks to understand their mechanisms better. The conversation concludes with insights into long-range regulatory associations in Drosophila, emphasizing the punctual interactions between transcription factor binding sites and their effect on neural gene transcription and genome folding.   References Gambetta, M. C., Oktaba, K., & Müller, J. (2009). Essential role of the glycosyltransferase sxc/Ogt in polycomb repression. Science (New York, N.Y.), 325(5936), 93–96. https://doi.org/10.1126/science.1169727 Kaushal, A., Mohana, G., Dorier, J., Özdemir, I., Omer, A., Cousin, P., Semenova, A., Taschner, M., Dergai, O., Marzetta, F., Iseli, C., Eliaz, Y., Weisz, D., Shamim, M. S., Guex, N., Lieberman Aiden, E., & Gambetta, M. C. (2021). CTCF loss has limited effects on global genome architecture in Drosophila despite critical regulatory functions. Nature communications, 12(1), 1011. https://doi.org/10.1038/s41467-021-21366-2 Hoencamp, C., Dudchenko, O., Elbatsh, A. M. O., Brahmachari, S., Raaijmakers, J. A., van Schaik, T., Sedeño Cacciatore, Á., Contessoto, V. G., van Heesbeen, R. G. H. P., van den Broek, B., Mhaskar, A. N., Teunissen, H., St Hilaire, B. G., Weisz, D., Omer, A. D., Pham, M., Colaric, Z., Yang, Z., Rao, S. S. P., Mitra, N., … Rowland, B. D. (2021). 3D genomics across the tree of life reveals condensin II as a determinant of architecture type. Science (New York, N.Y.), 372(6545), 984–989. https://doi.org/10.1126/science.abe2218 Mohana, G., Dorier, J., Li, X., Mouginot, M., Smith, R. C., Malek, H., Leleu, M., Rodriguez, D., Khadka, J., Rosa, P., Cousin, P., Iseli, C., Restrepo, S., Guex, N., McCabe, B. D., Jankowski, A., Levine, M. S., & Gambetta, M. C. (2023). Chromosome-level organization of the regulatory genome in the Drosophila nervous system. Cell, 186(18), 3826–3844.e26. https://doi.org/10.1016/j.cell.2023.07.008   Related Episodes Hi-C and Three-Dimensional Genome Sequencing (Erez Lieberman Aiden) Biophysical Modeling of 3-D Genome Organization (Leonid Mirny) Long-Range Transcriptional Control by 3D Chromosome Structure (Luca Giorgetti)   Contact Epigenetics Podcast on Twitter/X Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Active Motif on Twitter Active Motif on LinkedIn Email: podcast@activemotif.com

Enjoying our content and want to support us directly? Join our premium subscription for access to our podcasts, bonus content, merch discounts and more! Visit: www.psych2go.supercast.com Do you have a crush on someone? Have you ever wanted to impress your crush? Are you clueless when it comes to dating? If only they saw some of your great qualities, they may just like you. But how can you get them to notice you first? Here are just a few psychological ways to impress your crush. Not sure if your crush likes you? We also made a video on the signs your crush likes you back: https://youtu.be/VJFimZterSg Writer: Michal Mitchell Script Editor & Manager: Kelly Soong VO: Amanda Silvera Animator: Faye Miravalles YouTube Manager: Cindy Cheong Reference: Williams, L. E., & Bargh, J. A. (2008, October 24). Experiencing physical warmth promotes interpersonal warmth. Science (New York, N.Y.). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737341/. Skowronski, J. J., Carlston, D. E., Mae, L., & Crawford, M. T. (1998). Spontaneous trait transference: communicators taken on the qualities they describe in others. Journal of personality and social psychology, 74(4), 837–848. https://doi.org/10.1037//0022-3514.74.4.837 Hamburg, M. E., Finkenauer, C., & Schuengel, C. (2014). Food for love: the role of food offering in empathic emotion regulation. Frontiers in psychology, 5, 32. https://doi.org/10.3389/fpsyg.2014.00032 Polman, E., & Maglio, S. J. (2017). Mere Gifting: Liking a Gift More Because It Is Shared. Personality and Social Psychology Bulletin, 43(11), 1582–1594. https://doi.org/10.1177/0146167217718525 Lewandowski, D. G. (2018, July 30). Top 5 Classic Studies in the Psychology of Attraction. Luvze. https://www.luvze.com/top-5-classic-studies-in-the-psychology-of-attraction/. 8 Nifty Psychological Tricks That Can Make You Irresistible. BrightSide. (2019, September 6). https://brightside.me/inspiration-psychology/8-nifty-psychological-tricks-that-can-make-you-irresistible-794120/. #crush #psych2go #love Chatel, A. (2015, February 26). When It Comes to Romance, Science Has Good News for Adrenaline Junkies. Mic. https://www.mic.com/articles/111382/when-it-comes-to-romance-science-has-good-news-for-adrenaline-junkies. Effectiviology. https://effectiviology.com/humor-effect/. Join this channel to get access to perks: https://www.youtube.com/channel/UCkJEpR7JmS36tajD34Gp4VA/join Would you like to animate for the team? Check out this: https://psych2go.net/interested-in-animating-for-pych2go-faq/ Interested in writing for psych2go? Check out: https://psych2go.net/script-writing-position-faqs/ We're also on a mission to make mental health accessible around the world. Many of our content are translated to other languages by fans and people like you guys :) 1) Psych2Go Kr - https://www.youtube.com/channel/UCQh9DSw0L23tNULgxussrYg 심리툰 Psych2Go Korea https://www.youtube.com/channel/UCNTGv5tBhqxIN3jAHbhumeQ 2) Vietnamese - https://www.youtube.com/channel/UCe-DaRWfYRVfcdasozr874A 3) German - https://www.youtube.com/c/Psych2GoDE/videos 4) Indonesian - https://www.youtube.com/channel/UCwc1rtdEJDr-VKQT5bijwwQ 5) Russian - youtube.com/channel/UC4vMpG7hqxT0GCx2YAIF7rA/ 6) Vietnamese - https://www.youtube.com/channel/UCe-DaRWfYRVfcdasozr874A 7) Español - https://www.youtube.com/channel/UCl5OsVzh4_Xf8fSmxhOMP5Q 8) Hindi - https://www.youtube.com/channel/UCcesO-EWK1l6dF2QgB9aUkw

This episode of Brain Science features the return of molecular biologist Seth Grant. We briefly review his decades of research into the complexity of the protein structure of the synapse and then we focus on his most recent paper, which describes how the life-span of synapse proteins appears to change as animals age. Grant reflects of the significance of this finding both for animal research and human medicine. Papers discussed in this episode:  Bulovaite, E., Qiu, Z., Kratschke, M., Zgraj, A., Fricker, D. G., Tuck, E. J., Gokhale, R., Koniaris, B., Jami, S. A., Merino-Serrais, P., Husi, E., Mendive-Tapia, L., Vendrell, M., O'Dell, T. J., DeFelipe, J., Komiyama, N. H., Holtmaat, A., Fransén, E., & Grant, S. G. N. (2022). A brain atlas of synapse protein lifetime across the mouse lifespan. Neuron, 110(24), 4057–4073.e8. https://doi.org/10.1016/j.neuron.2022.09.009 Cizeron, M., Qiu, Z., Koniaris, B., Gokhale, R., Komiyama, N. H., Fransén, E., & Grant, S. G. N. (2020). A brainwide atlas of synapses across the mouse life span. Science (New York, N.Y.), 369(6501), 270–275. https://doi.org/10.1126/science.aba3163 Seth Grant has previously appeared on Brain Science several times including BSP 51, BSP 101, BS 137, BSP 150 and BS 176.   Announcements: Please FOLLOW the Brain Science podcast channel on YouTube. The mobile app has been updated and is now called Brain Science Podcast. The app is free and MyLibsyn Premium subscribers can use it to access transcripts and other premium content. Dr. Campbell arrived in New Zealand on August 10, 2023. Please reach out if you live in New Zealand or Australia. Please subscribe or follow Brain Science in your favorite audio app and please share it with others. Get free gift "5 Things You Need to Know about YOUR Brain when you sign up for the free Brain ScienceNewsletter to get show notes automatically every month. You can also text brainscience to 55444 to sign up. Support Brain Science by buying Are You Sure? The Unconscious Origins of Certainty by Virginia "Ginger" Campbell, MD. (Autographed copies are available) Learn more ways to support Brain Science at https://brainsciencepodcast.com/premium Connect on Social Media: Mastadon: https://neuromatch.social/@docartemis Twitter: @docartemis Facebook page: http://www.facebook.com/brainsciencepodcast Contact Dr. Campbell: Email: brainsciencepodcast@gmail.com

Enjoying our content and want to support us directly? Join our premium subscription for access to our podcasts, bonus content, merch discounts and more! Visit: www.psych2go.supercast.com Do you have a crush on someone? Have you ever wanted to impress your crush? Are you clueless when it comes to dating? If only they saw some of your great qualities, they may just like you. But how can you get them to notice you first? Here are just a few psychological ways to impress your crush. Not sure if your crush likes you? We also made a video on the signs your crush likes you back: https://youtu.be/VJFimZterSg Writer: Michal Mitchell Script Editor & Manager: Kelly Soong VO: Amanda Silvera Animator: Faye Miravalles YouTube Manager: Cindy Cheong Reference: Williams, L. E., & Bargh, J. A. (2008, October 24). Experiencing physical warmth promotes interpersonal warmth. Science (New York, N.Y.). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737341/. Skowronski, J. J., Carlston, D. E., Mae, L., & Crawford, M. T. (1998). Spontaneous trait transference: communicators taken on the qualities they describe in others. Journal of personality and social psychology, 74(4), 837–848. https://doi.org/10.1037//0022-3514.74.4.837 Hamburg, M. E., Finkenauer, C., & Schuengel, C. (2014). Food for love: the role of food offering in empathic emotion regulation. Frontiers in psychology, 5, 32. https://doi.org/10.3389/fpsyg.2014.00032 Polman, E., & Maglio, S. J. (2017). Mere Gifting: Liking a Gift More Because It Is Shared. Personality and Social Psychology Bulletin, 43(11), 1582–1594. https://doi.org/10.1177/0146167217718525 Lewandowski, D. G. (2018, July 30). Top 5 Classic Studies in the Psychology of Attraction. Luvze. https://www.luvze.com/top-5-classic-studies-in-the-psychology-of-attraction/. 8 Nifty Psychological Tricks That Can Make You Irresistible. BrightSide. (2019, September 6). https://brightside.me/inspiration-psychology/8-nifty-psychological-tricks-that-can-make-you-irresistible-794120/. #crush #psych2go #love Chatel, A. (2015, February 26). When It Comes to Romance, Science Has Good News for Adrenaline Junkies. Mic. https://www.mic.com/articles/111382/when-it-comes-to-romance-science-has-good-news-for-adrenaline-junkies. Effectiviology. https://effectiviology.com/humor-effect/. Join this channel to get access to perks: https://www.youtube.com/channel/UCkJEpR7JmS36tajD34Gp4VA/join Would you like to animate for the team? Check out this: https://psych2go.net/interested-in-animating-for-pych2go-faq/ Interested in writing for psych2go? Check out: https://psych2go.net/script-writing-position-faqs/ We're also on a mission to make mental health accessible around the world. Many of our content are translated to other languages by fans and people like you guys :) 1) Psych2Go Kr - https://www.youtube.com/channel/UCQh9DSw0L23tNULgxussrYg 심리툰 Psych2Go Korea https://www.youtube.com/channel/UCNTGv5tBhqxIN3jAHbhumeQ 2) Vietnamese - https://www.youtube.com/channel/UCe-DaRWfYRVfcdasozr874A 3) German - https://www.youtube.com/c/Psych2GoDE/videos 4) Indonesian - https://www.youtube.com/channel/UCwc1rtdEJDr-VKQT5bijwwQ 5) Russian - youtube.com/channel/UC4vMpG7hqxT0GCx2YAIF7rA/ 6) Vietnamese - https://www.youtube.com/channel/UCe-DaRWfYRVfcdasozr874A 7) Español - https://www.youtube.com/channel/UCl5OsVzh4_Xf8fSmxhOMP5Q 8) Hindi - https://www.youtube.com/channel/UCcesO-EWK1l6dF2QgB9aUkw

In this episode of the Epigenetics Podcast, we talked with Mary Gehring from MIT about her work on transgenerational inheritance and epigenetic imprinting in plants. Mary Gehring and her team are focusing on plant epigenetics and genetic imprinting in plants, studying DNA methylation in Arabidopsis. They have found significant differences in DNA methylation between the embryo and endosperm of plants, particularly in relation to imprinted genes. She also discusses their work on hydroxymethylcytosine (5-hmC) in Arabidopsis and the challenges of detecting and studying this epigenetic modification. Next, we discuss the regulatory circuit involving ROS1, a DNA glycosylase involved in demethylation, and its role in maintaining epigenetic homeostasis. The interview concludes with a discussion of CUT&RUN, which the lab has adapted for use in plants. Due to its low input requirements this method has been valuable in studying various plant tissues and has influenced Mary Gehring's research on imprinting in Arabidopsis endosperm.   References Gehring, M., Bubb, K. L., & Henikoff, S. (2009). Extensive demethylation of repetitive elements during seed development underlies gene imprinting. Science (New York, N.Y.), 324(5933), 1447–1451. https://doi.org/10.1126/science.1171609 Pignatta, D., Erdmann, R. M., Scheer, E., Picard, C. L., Bell, G. W., & Gehring, M. (2014). Natural epigenetic polymorphisms lead to intraspecific variation in Arabidopsis gene imprinting. eLife, 3, e03198. https://doi.org/10.7554/eLife.03198 Klosinska, M., Picard, C. L., & Gehring, M. (2016). Conserved imprinting associated with unique epigenetic signatures in the Arabidopsis genus. Nature plants, 2, 16145. https://doi.org/10.1038/nplants.2016.145 Zheng, X. Y., & Gehring, M. (2019). Low-input chromatin profiling in Arabidopsis endosperm using CUT&RUN. Plant reproduction, 32(1), 63–75. https://doi.org/10.1007/s00497-018-00358-1   Related Episodes The Role of Small RNAs in Transgenerational Inheritance in C. elegans (Oded Rechavi) Epigenetic Influence on Memory Formation and Inheritance (Isabelle Mansuy) The Epigenetics of Human Sperm Cells (Sarah Kimmins)   Contact Epigenetics Podcast on Twitter Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Active Motif on Twitter Active Motif on LinkedIn Email: podcast@activemotif.com

Découvrez le livre NEUROSAPIENS, sorti le 26 janvier aux éditions Les Arènes !  Pour apprendre à créer rapidement et à moindre coût son podcast, c'est par ici !  Nous allons parler thunes, blé, denier, écus, fric, oseille ou encore moula. Bref, nous allons parler argent. Et oui, je sais, en France, ça ne se fait pas trop de parler argent, par conséquent je vous propose non pas UN épisode mais DEUX épisodes sur le sujet. Deux épisodes, pour la simple raison que l'argent est un sujet complexe, qui soutient notre fonctionnement économique et social, qui entoure notre passé, présent et futur, qui impacte notre personnalité, nos rêves, notre santé mentale mais aussi nos relations sociales, nos vies professionnelles et notre descendance. Dans cet épisode, on va parler du fait que notre perception de l'argent varie selon ce à quoi nous le destinons, on va parler du fait que payer en espèce vs payer en carte de crédit n'a pas le même effet sur votre cerveau. Et puis  nous allons partir du côté des émotions générées par l'argent. Nous allons voir comment le manque d'argent peut générer un stress perturbant les fonctions cognitives, et nous allons nous poser la fameuse question suivante : l'argent fait-il le bonheur ?  Production, animation, réalisation et illustration : Anaïs Roux Instagram : https://www.instagram.com/neurosapiens.podcast/ neurosapiens.podcast@gmail.com Produit et distribué en association avec LACME Production. _________ Musique  KEEP ON GOING Musique proposée par La Musique Libre Joakim Karud - Keep On Going : https://youtu.be/lOfg0jRqaA8 Joakim Karud : https://soundcloud.com/joakimkarud ONE NIGHT AWAY Musique de Patrick Patrikios _________ Sources :  Tversky, A., & Kahneman, D. (1983). Extensional versus intuitive reasoning: The conjunction fallacy in probability judgment. Psychological Review, 90(4), 293–315. https://doi.org/10.1037/0033-295X.90.4.293 Prelec, D., Simester, D. Always Leave Home Without It: A Further Investigation of the Credit-Card Effect on Willingness to Pay. Marketing Letters 12, 5–12 (2001). https://doi.org/10.1023/A:1008196717017 Mazar, Nina & Plassmann, Hilke & Robitaille, Nicole & Lindner, Axel. (2017). Pain of Paying? — A Metaphor Gone Literal: Evidence from Neural and Behavioral Science.  Dunn, Elizabeth & Aknin, Lara & Norton, Michael. (2008). Spending Money on Others Promotes Happiness. Science (New York, N.Y.). 319. 1687-8. 10.1126/science.1150952.  Moll J, Krueger F, Zahn R, Pardini M, de Oliveira-Souza R, Grafman J. Human fronto-mesolimbic networks guide decisions about charitable donation. Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15623-8. doi: 10.1073/pnas.0604475103. Epub 2006 Oct 9. PMID: 17030808; PMCID: PMC1622872.

In this episode of the Epigenetics Podcast, we caught up with Lucas Farnung from Harvard Medical School to talk about his work on the structural analysis of nucleosomes during transcription. Lucas Farnung started his scientific career in Patrick Cramer's lab, trying to solve the cryo-EM structure of RNA polymerase II transcribing through a nucleosome. This project spanned some time before being published in 2018, during which time Dr. Farnung accomplished several other goals. The team solved the cryo-electron microscopy structure of Chd1 from the yeast Saccharomyces cerevisiae bound to a nucleosome at a resolution of 4.8 Å, solved the structure of the nucleosome-CHD4 chromatin remodeler, and investigated the structural basis of nucleosome transcription mediated by Chd1 and FACT. In 2021, he started his own lab and is now working on structural analysis of nucleosomes during transcription and how chromatin remodelers work on the chromatin template. References Farnung, L., Vos, S. M., Wigge, C., & Cramer, P. (2017). Nucleosome-Chd1 structure and implications for chromatin remodelling. Nature, 550(7677), 539–542. https://doi.org/10.1038/nature24046 Farnung, L., Vos, S. M., & Cramer, P. (2018). Structure of transcribing RNA polymerase II-nucleosome complex. Nature communications, 9(1), 5432. https://doi.org/10.1038/s41467-018-07870-y Filipovski, M., Soffers, J. H. M., Vos, S. M., & Farnung, L. (2022). Structural basis of nucleosome retention during transcription elongation. Science (New York, N.Y.), 376(6599), 1313–1316. https://doi.org/10.1126/science.abo3851   Related Episodes Molecular Mechanisms of Chromatin Modifying Enzymes (Karim-Jean Armache) Regulation of Chromatin Organization by Histone Chaperones (Geneviève Almouzni) Transcription Elongation Control by the Paf1 Complex (Karen Arndt) From Nucleosome Structure to Function (Karolin Luger)   Contact Epigenetics Podcast on Twitter Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Active Motif on Twitter Active Motif on LinkedIn Email: podcast@activemotif.com

Découvrez le livre NEUROSAPIENS, sorti le 26 janvier aux éditions Les Arènes !  Pour apprendre à créer rapidement et à moindre coût son podcast, c'est par ici !  Nous allons parler thunes, blé, denier, écus, fric, oseille ou encore moula. Bref, nous allons parler argent. Et oui, je sais, en France, ça ne se fait pas trop de parler argent, par conséquent je vous propose non pas UN épisode mais DEUX épisodes sur le sujet. Deux épisodes, pour la simple raison que l'argent est un sujet complexe, qui soutient notre fonctionnement économique et social, qui entoure notre passé, présent et futur, qui impacte notre personnalité, nos rêves, notre santé mentale mais aussi nos relations sociales, nos vies professionnelles et notre descendance. La première partie qui est celle d'aujourd'hui, se concentrera sur l'argent et son impact sur notre cerveau, nos comportements, nos émotions. Que se passe-t-il dans le cerveau lorsque l'argent entre en jeu ? Existent-ils des neurones de l'argent ?  Production, animation, réalisation et illustration : Anaïs Roux Instagram : https://www.instagram.com/neurosapiens.podcast/ neurosapiens.podcast@gmail.com Produit et distribué en association avec LACME Production. _________ Musique  KEEP ON GOING Musique proposée par La Musique Libre Joakim Karud - Keep On Going : https://youtu.be/lOfg0jRqaA8 Joakim Karud : https://soundcloud.com/joakimkarud ONE NIGHT AWAY Musique de Patrick Patrikios _________ Sources :  C. Tallon-Baudry et al., in PloSONE vol. 6, e28229, 2011. Breiter HC, Gollub RL, Weisskoff RM, Kennedy DN, Makris N, Berke JD, Goodman JM, Kantor HL, Gastfriend DR, Riorden JP, Mathew RT, Rosen BR, Hyman SE. Acute effects of cocaine on human brain activity and emotion. Neuron. 1997 Sep;19(3):591-611. doi: 10.1016/s0896-6273(00)80374-8. PMID: 9331351.  Sescousse G, Redouté J, Dreher JC. The architecture of reward value coding in the human orbitofrontal cortex. J Neurosci. 2010 Sep 29;30(39):13095-104. doi: 10.1523/JNEUROSCI.3501-10.2010. PMID: 20881127; PMCID: PMC6633499. https://hbr.org/2015/10/what-happens-to-your-brain-when-you-negotiate-about-money Sanfey, Alan & Rilling, James & Aronson, Jessica & Nystrom, Leigh & Cohen, Jonathan. (2003). The Neural Basis of Economic Decision-Making in the Ultimatum Game. Science (New York, N.Y.). 300. 1755-8. 10.1126/science.1082976.  Cristofori I, Harquel S, Isnard J, Mauguière F, Sirigu A. Monetary reward suppresses anterior insula activity during social pain. Soc Cogn Affect Neurosci. 2015 Dec;10(12):1668-76. doi: 10.1093/scan/nsv054. Epub 2015 May 11. PMID: 25964499; PMCID: PMC4666104.

In this episode of the Epigenetics Podcast, we caught up with Luciano Di Croce from the Center of Genomic Regulation in Barcelona to talk about his work on epigenetic landscapes in cancer. The Di Croce Lab focuses on the Polycomb Complex and its influence on diseases like cancer. Luciano Di Croce started out his research career investigating the oncogenic transcription factor PML-RAR. They could show that in leukemic cells knockdown of SUZ12, a key component of Polycomb repressive complex 2 (PRC2), reverts not only histone modification but also induces DNA de-methylation of PML-RAR target genes. More recently the team focused on two other Polycomb related proteins Zrf1 and PHF19 and were able to characterize some of their functions in gene targeting in different disease and developmental contexts.   References Di Croce, L., Raker, V. A., Corsaro, M., Fazi, F., Fanelli, M., Faretta, M., Fuks, F., Lo Coco, F., Kouzarides, T., Nervi, C., Minucci, S., & Pelicci, P. G. (2002). Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor. Science (New York, N.Y.), 295(5557), 1079–1082. https://doi.org/10.1126/science.1065173 Richly, H., Rocha-Viegas, L., Ribeiro, J. D., Demajo, S., Gundem, G., Lopez-Bigas, N., Nakagawa, T., Rospert, S., Ito, T., & Di Croce, L. (2010). Transcriptional activation of polycomb-repressed genes by ZRF1. Nature, 468(7327), 1124–1128. https://doi.org/10.1038/nature09574 Jain, P., Ballare, C., Blanco, E., Vizan, P., & Di Croce, L. (2020). PHF19 mediated regulation of proliferation and invasiveness in prostate cancer cells. eLife, 9, e51373. https://doi.org/10.7554/eLife.51373   Related Episodes Oncohistones as Drivers of Pediatric Brain Tumors (Nada Jabado) Transcription and Polycomb in Inheritance and Disease (Danny Reinberg) Targeting COMPASS to Cure Childhood Leukemia (Ali Shilatifard)   Contact Epigenetics Podcast on Twitter Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Active Motif on Twitter Active Motif on LinkedIn Email: podcast@activemotif.com

In this episode of the Epigenetics Podcast, we caught up with Sarah Kimmins from Université de Montreal to talk about her work on the epigenetics of human sperm cells. The focus of Sarah Kimmins and her lab is how sperm and offspring health is impacted by the father's environment. The core of this is the sperm epigenome, which has been implicated in complex diseases such as infertility, cancer, diabetes, schizophrenia and autism. The Kimmins lab is interested which players play a role in this and came across the Histone post-translational modification H3K4me3. In this interview we talk about how the father's life choices can impact offspring health, which can also be inherited transgenerationally and how this can be used to develop intervention strategies to improve child and adult health.   References Siklenka, K., Erkek, S., Godmann, M., Lambrot, R., McGraw, S., Lafleur, C., Cohen, T., Xia, J., Suderman, M., Hallett, M., Trasler, J., Peters, A. H., & Kimmins, S. (2015). Disruption of histone methylation in developing sperm impairs offspring health transgenerationally. Science (New York, N.Y.), 350(6261), aab2006. https://doi.org/10.1126/science.aab2006 Lismer, A., Siklenka, K., Lafleur, C., Dumeaux, V., & Kimmins, S. (2020). Sperm histone H3 lysine 4 trimethylation is altered in a genetic mouse model of transgenerational epigenetic inheritance. Nucleic acids research, 48(20), 11380–11393. https://doi.org/10.1093/nar/gkaa712 Lismer, A., Dumeaux, V., Lafleur, C., Lambrot, R., Brind'Amour, J., Lorincz, M. C., & Kimmins, S. (2021). Histone H3 lysine 4 trimethylation in sperm is transmitted to the embryo and associated with diet-induced phenotypes in the offspring. Developmental cell, 56(5), 671–686.e6. https://doi.org/10.1016/j.devcel.2021.01.014   Related Episodes H3K4me3, SET Proteins, Isw1, and their Role in Transcription (Jane Mellor) The Effects of Early Life Stress on Mammalian Development (Catherine J. Peña) DNA Methylation and Mammalian Development (Déborah Bourc'his)   Contact Epigenetics Podcast on Twitter Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Active Motif on Twitter Active Motif on LinkedIn Email: podcast@activemotif.com

In this episode of the Epigenetics Podcast, we caught up with Karim-Jean Armache from New York University - Grossman School of Medicine to talk about his work on the structural analysis of Polycomb Complex Proteins. Karim-Jean Armache started his research career with the structural characterization of the 12-subunit RNA Polymerase II. After starting his own lab he used this knowledge in x-ray crystallography and electron microscopy to study how gene silencing complexes like the PRC complex act on chromatin and influence transcription. Further work in the Armache Lab focused on Dot, a  histone H3K79 methyltransferase, and how it acts on chromatin, as well as how it is regulated by Histone-Histone crosstalk. References Armache, K. J., Garlick, J. D., Canzio, D., Narlikar, G. J., & Kingston, R. E. (2011). Structural basis of silencing: Sir3 BAH domain in complex with a nucleosome at 3.0 Å resolution. Science (New York, N.Y.), 334(6058), 977–982. https://doi.org/10.1126/science.1210915 Lee, C. H., Holder, M., Grau, D., Saldaña-Meyer, R., Yu, J. R., Ganai, R. A., Zhang, J., Wang, M., LeRoy, G., Dobenecker, M. W., Reinberg, D., & Armache, K. J. (2018). Distinct Stimulatory Mechanisms Regulate the Catalytic Activity of Polycomb Repressive Complex 2. Molecular cell, 70(3), 435–448.e5. https://doi.org/10.1016/j.molcel.2018.03.019 De Ioannes, P., Leon, V. A., Kuang, Z., Wang, M., Boeke, J. D., Hochwagen, A., & Armache, K. J. (2019). Structure and function of the Orc1 BAH-nucleosome complex. Nature communications, 10(1), 2894. https://doi.org/10.1038/s41467-019-10609-y Valencia-Sánchez, M. I., De Ioannes, P., Wang, M., Truong, D. M., Lee, R., Armache, J. P., Boeke, J. D., & Armache, K. J. (2021). Regulation of the Dot1 histone H3K79 methyltransferase by histone H4K16 acetylation. Science (New York, N.Y.), 371(6527), eabc6663. https://doi.org/10.1126/science.abc6663   Related Episodes Transcription and Polycomb in Inheritance and Disease (Danny Reinberg) From Nucleosome Structure to Function (Karolin Luger) Oncohistones as Drivers of Pediatric Brain Tumors (Nada Jabado)   Contact Epigenetics Podcast on Twitter Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Active Motif on Twitter Active Motif on LinkedIn eMail: podcast@activemotif.com

In this episode of the Epigenetics Podcast, we caught up with Active Motif's own Yuan Xue to talk about some of the challenges of performing ATAC-Seq. ATAC-Seq stands for Assay for Transposase-Accessible Chromatin with high-throughput sequencing and was initially described by Jason Buenrostro in 2013. The ATAC-Seq method relies on next-generation sequencing (NGS) library construction using the hyperactive transposase Tn5. NGS adapters are loaded onto the transposase, which allows simultaneous fragmentation of chromatin and integration of those adapters into open chromatin regions. ATAC-Seq is an attractive method to start your epigenetic journey. Whether you want to analyze the state of the chromatin in your sample or compare the chromatin state before and after a special treatment, ATAC-Seq allows you to investigate genome-wide chromatin changes and can offer guidelines about which epigenetic modification or transcription factor should be studied next in the follow-up experiments and which method should be used to study them. In this Episode we go through the Protocol in detail and discuss potential challenges and points to pay attention to when starting your first ATAC-Seq experiment.   References ATAC-Seq Resource Center Complete Guide to Understanding and Using ATAC-Seq Beginner's Guide to Understanding Single-Cell ATAC-Seq Buenrostro, J. D., Giresi, P. G., Zaba, L. C., Chang, H. Y., & Greenleaf, W. J. (2013). Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position. Nature methods, 10(12), 1213–1218. https://doi.org/10.1038/nmeth.2688 Buenrostro, J. D., Wu, B., Litzenburger, U. M., Ruff, D., Gonzales, M. L., Snyder, M. P., Chang, H. Y., & Greenleaf, W. J. (2015). Single-cell chromatin accessibility reveals principles of regulatory variation. Nature, 523(7561), 486–490. https://doi.org/10.1038/nature14590 Cusanovich, D. A., Daza, R., Adey, A., Pliner, H. A., Christiansen, L., Gunderson, K. L., Steemers, F. J., Trapnell, C., & Shendure, J. (2015). Multiplex single cell profiling of chromatin accessibility by combinatorial cellular indexing. Science (New York, N.Y.), 348(6237), 910–914. https://doi.org/10.1126/science.aab1601 Podcast: ATAC-Seq, scATAC-Seq and Chromatin Dynamics in Single-Cells (Jason Buenrostro)   Contact Active Motif on Twitter Epigenetics Podcast on Twitter Active Motif on LinkedIn Active Motif on Facebook Email: podcast@activemotif.com

Dr Peter A. McCullough, MD, MPH, is a board-certified cardiologist, internist, epidemiologist who has testified before committees of the US and multiple State Senates regarding the treatment of COVID-19 and management of the ongoing pandemic. He has been in practice for over 40 years as an active treating physician combined with a decorative academic career that has placed him the most published cardiologist of all time. Join us as we explore:If it is safe to vaccinate your children The very real risk of myocarditis If you can get C-19 twice, why vaccinating post-COVID infection is dangerous, a huge amount of false + cases, C-19's mass psychosis The overwhelming evidence natural immunity is “complete, robust and durable” and “infinitely” superior to vaccinationMENTIONS:Avolio, E., et al. (2021). The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147 receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular disease. Clinical science (London, England : 1979), 135(24), 2667–2689. https://doi.org/10.1042/CS20210735 SARS-CoV-2 mRNA Vaccination-Associated Myocarditis in Children Ages 12-17: A Stratified National Database Analysis. Tracy Beth Høeg, et al.medRxiv 2021.08.30.21262866; doi: https://doi.org/10.1101/2021.08.30.21...    Lim, Y., Kim, M. C., Kim, K. H., Jeong, I. S., Cho, Y. S., Choi, Y. D., & Lee, J. E. (2021). Case Report: Acute Fulminant Myocarditis and Cardiogenic Shock After Messenger RNA Coronavirus Disease 2019 Vaccination Requiring Extracorporeal Cardiopulmonary Resuscitation. Frontiers in cardiovascular medicine, 8, 758996. https://doi.org/10.3389/fcvm.2021.758996 Choi, S., Lee, et al.  (2021). Myocarditis-induced Sudden Death after BNT162b2 mRNA COVID-19 Vaccination in Korea: Case Report Focusing on Histopathological Findings. Journal of Korean medical science, 36(40), e286. https://doi.org/10.3346/jkms.2021.36....Professor Mattias Desmet https://www.ugent.be/psync/en/who/des...Shedding of Infectious SARS-CoV-2 Despite VaccinationKasen et al. medRxiv 2021.07.31.21261387; doi: https://doi.org/10.1101/2021.07.31.21... 141 Studies Showing Natural Immunity (up from 128)https://brownstone.org/articles/79-re... https://www.thegatewaypundit.com/2021... “Risks of Vaccines for Those Recovered from COVID-19 – Krammer, Raw & Mathioudakis”https://www.americaoutloud.com/risks-...  Cohn, B. A., et al (2021). SARS-CoV-2 vaccine protection and deaths among US veterans during 2021. Science (New York, N.Y.), eabm0620. Advance online publication. https://doi.org/10.1126/science.abm0620Effectiveness of heterologous ChAdOx1 nCoV-19 and mRNA prime-boost vaccination against symptomatic Covid-19 infection in Sweden: A nationwide cohort study. Peter Nordström, et al. The Lancet Regional Health – Europe.  December 2021. https://www.thelancet.com/journals/la...  “Failure of Vaccines and Truth Revealed”. https://www.americaoutloud.com/failur... COVID-19-associated hospitalizations among vaccinated and unvaccinated adults ≥18 years – COVID-NET, 13 states, January 1 – July 24, 2021. Fiona P. Havers, et al. medRxiv 2021.08.27.21262356; doi:https://doi.org/10.1101/2021.08.27.21...Antigenic minimalism of SARS-CoV-2 is linked to surges in COVID-19 community transmission and vaccine breakthrough infections. A.J. Venkatakrishnan, et al. medRxiv 2021.05.23.21257668; doi:https://doi.org/10.1101/2021.05.23.21...Kostoff, R. N., et al. (2021). Why are we vaccinating children against COVID-19?. Toxicology reports, 8, 1665–1684. https://doi.org/10.1016/j.toxrep.2021...Disclaimer policy for all of our videos. https://madetothrive.co.za/terms-and-...

In der Folge hinter dem 10. Türchen unseres Dog about Life Adventspecials dreht sich alles um das Thema Biophilie und unsere tiefe Verbundenheit mit der Natur und mit Tieren. Haben Tiere und die Natur wirklich eine positive Wirkung auf unser Gesundheit? Macht sich die Distanz zur Natur bei Menschen, die in Städten leben, auch bemerkbar? Welche Rolle spielen unsere Hunde in dem Konzept der Biophilie? Über all das und noch einiges mehr spricht Anna in dieser Folge. Hört unbedingt rein!Quellen:|| Kontakt:dogaboutlife@gmail.com|| Instagram: @dogaboutlifePatrizia: @fuxliebe Alice: @minniefairytailAnna: @loewenpfoten|| Logo Credits:Katleen Ackers https://katleenackers.de/|| Music Credits:Music from https://www.zapsplat.com|| Quellen:|| Ulrich, Roger. (1984). View Through a Window May Influence Recovery from Surgery. Science (New York, N.Y.) 224.420-1.|| Wilson, E. O., & Kellert, S. R. (1995). The Biophilia Hypothesis. Washington: Island Press. || Dr. Feddersen-Petersen, Dorit Urd. (2008). Ausdrucksverhalten beim Hund. Stuttgart: Franckh-Kosmos Verlag. || Wikipedia: https://de.wikipedia.org/wiki/Zoophilie, abgerufen am 02.12.2021|| Adli, Mazda., & Schöndorf, Jonas. (2020). Macht uns die Stadt krank? Wirkungen von Stadtstress auf Emotionen, Verhalten und psychische Gesundheit. Bundesgesundheitsblatt. 63. 799-986 || Fromm, Erich (1987). Die Seele des Menschen. Ihre Fähigkeit zum Guten und zum Bösen. Ullstein Materialien.|| Li, Qing. (2009). Effect of forest bathing trips on human immune function. Environ Health Prev Med. 15 (1). 9-17.|| Grübner, Oliver., Rapp, Michael., Adli, Mazda., Kluge, Ulrike., Galea, Sandro., & Heinz, Andreas. (2017). Cities and Mental Health. Deutsches Ärzteblatt International. 114 (8). 121-127.|| Holt-Lunstad, J., Smith, TB., & Layton, JB. (2010). Social relationships and mortality risk: a meta-analytic review. PLoSMed7. || Kotrschal, Kurt. (2020). Hund und Mensch. 6. Auflage. Wien: Christian Brandstätter Verlag GmbH & Co KG.|| Friedmann, E., Katcher, AH., Lynch, JJ., & Thomas, SA. (1980). Animal companions and one year survival of patients after discharge from a coronary care unit. Public Health Reports. 95. 307-312.|| Friedmann, E., Barker, SB., & Allen, KM. (2011). Physiological correlates of health benefits from pets. In P. McCardle, S. McCune, J. A. Griffin, & V. Maholmes (Eds.), How animals affect us: Examining the influences of human–animal interaction on child development and human health (pp. 163–182). American Psychological Association.|| https://www.erna-graff-stiftung.de/du-evidenz/, abgerufen am 02.12.2021

In the second episode Emese Domahidi (Assistant Professor at TU Ilmenau) and Mario Haim (Assistant Professor at the U of Leipzig) discuss with Wouter van Atteveldt (Associate Professor at Vrije Universiteit Amsterdam) the role of communication science in the field. Main topics are the nature and role of data for the social sciences and challenges in collaborations with computer scientists. We touch on topics like open science, reproducibility and replicability for computational communication science and whether we need a cultural change to achieve these goals. Last but not least we talk about a new book Computational Analysis of Communication that Wouter co-edited with Damian Trilling and Carlos Arcila. References Lazer, D., Pentland, A. (Sandy), Adamic, L., Aral, S., Barabasi, A. L., Brewer, D., Christakis, N., Contractor, N., Fowler, J., Gutmann, M., Jebara, T., King, G., Macy, M., Roy, D., & Van Alstyne, M. (2009). Life in the network: The coming age of computational social science. Science (New York, N.Y.), 323(5915), 721–723. https://doi.org/10.1126/science.1167742 Roberts, M. E., Stewart, B. M., & Tingley, D. (2019). stm: An R Package for Structural Topic Models. Journal of Statistical Software, 91(2), 1–40. https://doi.org/10.18637/jss.v091.i02 van Atteveldt, W., Trilling, D., & Arcila, C. (in press). Computational Analysis of Communication. Wiley Blackwell. Book homepage: https://cssbook.net/

The idea that race is a biological reality has hung on longest and strongest in the parts of biological anthropology that deal with skeletal remains. In this episode we talk with two forensic anthropologists, Sean Tallman and Allysha Winburn, about how typological notions of race and ancestry have changed over time in this segment of the discipline. They have published a recent paper discussing this change (Tallman, S. D., Parr, N. M., & Winburn, A. P. (2021). Assumed Differences; Unquestioned Typologies: The Oversimplification of Race and Ancestry in Forensic Anthropology. Forensic Anthropology, Early View, 1-24. doi:https://doi.org/10.5744/fa.2020.0046). Additional resources: J. Bindon, M. Peterson, & L. J. Weaver (Producer). (2017, 11/14/2017). Race and the Human Genome Project [Retrieved from http://speakingofrace.ua.edu/podcast/race-and-the-human-genome-project Bindon, J. R. (2020). Race in the wake of the Human Genome Project. Retrieved from https://www.researchgate.net/publication/342215956_Race_in_the_wake_of_the_Human_Genome_Project Crews, D. E., & Bindon, J. R. (1991). Ethnicity as a taxonomic tool in biomedical and biosocial research. Ethnicity & disease, 1(1), 42-49. Dixon, R. B. (1923). The Racial History of Man. New York: C. Scribner's Sons. Holden, C. (2008). Personal genomics. The touchy subject of ‘race'. Science (New York, N.Y.), 322(5903), 839. Hooton, E. A. (1931). Up from the Ape. New York: Macmillan. Lieberman, L., Kirk, R. C., & Littlefield, A. (2003). Perishing Paradigm: Race—1931–99. American Anthropologist, 105(1), 110-113. Morning, A. (2011). The nature of race. Berkeley: University of California Press. Wagner, J. K., Yu, J. H., Ifekwunigwe, J. O., Harrell, T. M., Bamshad, M. J., & Royal, C. D. (2017). Anthropologists' views on race, ancestry, and genetics. American Journal of Physical Anthropology, 162(2), 318-327.

A depressão, também conhecida como transtorno depressivo maior, afeta mais de 260 milhões de pessoas ao redor do mundo. No mês de setembro, temos a campanha do Setembro Amarelo, dedicada à prevenção do suicídio. Todos os dias, cerca de 32 pessoas dão fim a própria vida. E estima-se que 96% dos casos estão relacionados com transtornos mentais, principalmente depressão. O 44º episódio do SciTalk examina a depressão além da tristeza, buscando entender as suas origens e sinais. ===== Caso você esteja passando por um momento difícil, procure ajuda no Centro de Valorização da Vida e o Centro de Atenção Psicossocial (CAP) da sua cidade. O CVV (https://www.cvv.org.br) funciona 24 horas por dia (inclusive aos feriados) pelo telefone 188, e também atende por e-mail, chat e pessoalmente. São mais de 120 postos de atendimento em todo o Brasil. ===== Apoie a produção do SciTalk: https://apoia.se/scitalk Instagram: https://www.instagram.com/scitalkpodcast Twitter: https://twitter.com/scitalkpodcast E-mail: scitalkpodcast@gmail.com ===== Luiz Hendrix (Host do SciTalk): Twitter: https://twitter.com/LuizHendrix Instagram: https://www.instagram.com/luizghsa ===== Referências: - Eisch, A. J. and Petrik, D. (2012) “Depression and hippocampal neurogenesis: a road to remission?,” Science (New York, N.Y.), 338(6103), pp. 72–75. - Pittenger, C. and Duman, R. S. (2008) “Stress, depression, and neuroplasticity: a convergence of mechanisms,” Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology, 33(1), pp. 88–109. - Rajkowska, G. (2003) “Depression: what we can learn from postmortem studies,” The Neuroscientist: a review journal bringing neurobiology, neurology and psychiatry, 9(4), pp. 273–284.

Carbono é o elemento mais importante encontrado no Planeta Terra. A partir dele, a vida se torna um milagre possível ao gerar muitos compostos diferentes. A curiosidade humana criou muitas perguntas durante todos esses séculos de desenvolvimento científico, incluindo a possibilidade de formas de vida não baseadas em carbono. Quer descobrir se isso é possível? Aperte o play no 39º episódio do SciTalk! ===== Financie o SciTalk: https://apoia.se/scitalk Instagram: https://www.instagram.com/scitalkpodcast Twitter: https://twitter.com/scitalkpodcast E-mail: scitalkpodcast@gmail.com ===== Luiz Hendrix (Host do SciTalk): Twitter: https://twitter.com/LuizHendrix Instagram: https://www.instagram.com/luizghsa ===== Referências: - Becker, R. (2016) Designer bacteria build carbon-silicon materials for the first time, The Verge. Available at: https://www.theverge.com/2016/11/29/13757524/silicon-carbon-organic-molecules-bacteria-living-cells-caltech. - Kan, S. B. J. et al. (2016) “Directed evolution of cytochrome c for carbon-silicon bond formation: Bringing silicon to life,” Science (New York, N.Y.), 354(6315), pp. 1048–1051. - Petkowski, J. J., Bains, W. and Seager, S. (2020) “On the potential of silicon as a building block for life,” Life (Basel, Switzerland), 10(6), p. 84. - Wolfe-Simon, F. et al. (2011) “A bacterium that can grow by using arsenic instead of phosphorus,” Science (New York, N.Y.), 332(6034), pp. 1163–1166.

In this episode, let's talk about where the link between vaccines and autism came from and why the myth still persists, despite ample amounts of research disproving that vaccines can cause autism. References: DeStefano, F., Price, C.S., & Weintraub, E.S. (2013). Increasing exposure to antibody-stimulating proteins and polysaccharides in vaccines is not associated with risk of autism. The Journal of Pediatrics, 163(2), 561-567. doi: 10.1016/j.jpeds.2013.02.001. DeStefano, R., Shimabukuro, T.T. (2019). The MMR vaccine and autism. Ann Rev Virol, 6(1), 1-16. DeStefano, R. (2007). Vaccines and Autism: Evidence Does Not Support a Causal Association. Clinical Pharmacology & Therapeutics. 82(6), 756-759. Gerber, J. S., & Offit, P. A. (2009). Vaccines and autism: a tale of shifting hypotheses. Clinical infectious diseases: an official publication of the Infectious Diseases Society of America, 48(4), 456–461. https://doi.org/10.1086/596476 Goin-Kochel, R.P., Mire, S.S., Dempsey, A.G., Fein, R.H., Guffey, D., Minard, C.G., Cunningham, R.M., Sahni, L.C., & Boom, J.A. (2016). Parental report of vaccine receipt in children with autism spectrum disorder: Do rates differ by pattern of ASD onset? Vaccine, 34(11), 13335-1342, doi: 10.1016/j.vaccine.2016.02.008. Makela, A., Nuorti, J. P., & Peltola, H. (2002). Neurologic disorders after measles-mumps-rubella vaccination. Pediatrics, 110(5), 957–963. https://doi.org/10.1542/peds.110.5.957 Morrow, E. M., Yoo, S. Y., Flavell, S. W., Kim, T. K., Lin, Y., Hill, R. S., Mukaddes, N. M., Balkhy, S., Gascon, G., Hashmi, A., Al-Saad, S., Ware, J., Joseph, R. M., Greenblatt, R., Gleason, D., Ertelt, J. A., Apse, K. A., Bodell, A., Partlow, J. N., Barry, B., Walsh, C. A. (2008). Identifying autism loci and genes by tracing recent shared ancestry. Science (New York, N.Y.), 321(5886), 218–223. https://doi.org/10.1126/science.1157657 Taylor, L.E., Swerdfeger, A.L., & Eslick, G.D. (2014). Vaccines are not associated with autism: An evidence-based meta-analysis of case-control and cohort studies. Vaccine, 32(29), 3623-3629. doi: 10.1016/j.vaccine.2014.04.085. Wakefield, A.J., Murch, S.H., Anthony, A., Linnell, J., Casson, D.M., Malik, M., Berelowitz, M., Dhillon, A.P., Thomson, M.A., Harvey, P., Valentine, A., Davies, S.E., & Walker-Smith, J.A. (1998). RETRACTED: Ileal-lymphoid-nodular hyperplasia, non-specific colitis and pervasive developmental disorder in children. The Lancet, 351(9103), 637–641. doi: 10.1016/S0140-6736(97)11096-0. For more information, head over to Aspect Australia - www.autismspectrum.org.au. Disclaimer: I'm not a professional, just a student with a passion for autism.

O ser humano caminha para um futuro onde a imortalidade poderá ser um novo começo para uma vida que sempre sonhamos em viver. Estaríamos livres da nosso corpo mortal, porém, presos em um ciberespaço onde a realidade é construída por código binário. Conheça a ciência e as consequências do armazenamento de mentes no 37º episódio do SciTalk. ===== Apoie o SciTalk: https://apoia.se/scitalk Instagram: https://www.instagram.com/scitalkpodcast Twitter: https://twitter.com/scitalkpodcast E-mail: scitalkpodcast@gmail.com ===== Luiz Hendrix (Host do SciTalk): Twitter: https://twitter.com/LuizHendrix Instagram: https://www.instagram.com/luizghsa ===== Referências: - Axmacher, N. et al. (2006) “Memory formation by neuronal synchronization,” Brain research reviews, 52(1), pp. 170–182. - Cappuccio, M. L. (2017) “Mind-upload. The ultimate challenge to the embodied mind theory,” Phenomenology and the cognitive sciences, 16(3), pp. 425–448. - Gonzalez, W. G. et al. (2019) “Persistence of neuronal representations through time and damage in the hippocampus,” Science (New York, N.Y.), 365(6455), pp. 821–825. - Laakasuo, M. et al. (2018) “What makes people approve or condemn mind upload technology? Untangling the effects of sexual disgust, purity and science fiction familiarity,” Palgrave communications, 4(1). doi: 10.1057/s41599-018-0124-6. - Oh, S. W. et al. (2014) “A mesoscale connectome of the mouse brain,” Nature, 508(7495), pp. 207–214.

In this episode of the Epigenetics Podcast, we caught up with Déborah Bourc'his from L'Institut Curie in Paris to talk about her work on the role of DNA methylation in mammalian development. During her postdoc years Déborah Bourc'his was able to characterize DNMT3L, a protein with unknown function at that time. It turned out that this protein is the cofactor responsible for stimulating DNA methylation activity in both the male and the female germline. Later on she discovered a novel DNA methylation enzyme called DNMT3C, which was unknown because it was not properly annotated, there was no sign of expression, and it was only expressed in male fetal germ cells. Furthermore, this enzyme only evolved in rodents, as a defense against young transposons. In this episode we discuss the story behind how Déborah Bourc'his was able to discover and characterize the DNA methylation enzymes DNMT3L and DNMT3C and their role in mammalian development.   References R. Duffie, S. Ajjan, … D. Bourc’his (2014) The Gpr1/Zdbf2 locus provides new paradigms for transient and dynamic genomic imprinting in mammals (Genes & Development) DOI: 10.1101/gad.232058.113 Natasha Zamudio, Joan Barau, … Déborah Bourc’his (2015) DNA methylation restrains transposons from adopting a chromatin signature permissive for meiotic recombination (Genes & Development) DOI: 10.1101/gad.257840.114](https://doi.org/10.1101/gad.257840.114) Marius Walter, Aurélie Teissandier, … Déborah Bourc’his (2016) An epigenetic switch ensures transposon repression upon dynamic loss of DNA methylation in embryonic stem cells (eLife) DOI: 10.7554/eLife.11418](https://doi.org/10.7554/eLife.11418) Joan Barau, Aurélie Teissandier, … Déborah Bourc’his (2016) The DNA methyltransferase DNMT3C protects male germ cells from transposon activity (Science (New York, N.Y.)) DOI: 10.1126/science.aah5143 Maxim V. C. Greenberg, Juliane Glaser, … Déborah Bourc’his (2017) Transient transcription in the early embryo sets an epigenetic state that programs postnatal growth (Nature Genetics) DOI: 10.1038/ng.3718 Roberta Ragazzini, Raquel Pérez-Palacios, … Raphaël Margueron (2019) EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells (Nature Communications) DOI: 10.1038/s41467-019-11800-x Dura, M., Teissandier, A., Armand, M., Barau, J., Bonneville, L., Weber, M., Baudrin, L. G., Lameiras, S., & Bourc’his, D. (2021). DNMT3A-dependent DNA methylation is required for spermatogonial stem cells to commit to spermatogenesis [Preprint]. Developmental Biology. https://doi.org/10.1101/2021.04.19.440465   Related Episodes Effects of DNA Methylation on Diabetes (Charlotte Ling) Epigenetic Reprogramming During Mammalian Development (Wolf Reik) Effects of DNA Methylation on Chromatin Structure and Transcription (Dirk Schübeler) CpG Islands, DNA Methylation, and Disease (Sir Adrian Bird)   Contact Active Motif on Twitter Epigenetics Podcast on Twitter Active Motif on LinkedIn Active Motif on Facebook Email: podcast@activemotif.com

We're back for season two! Today we're talking about reading—an activity you may be doing more or less of in these pandemic times. We bring on one of our most literary-minded pals, comedian and writer Nicole Drespel, to discuss the science behind what makes reading a form of self-care. Special shout outs to Scholastic Book Fairs, Dawson's Creek, and your aunt's favorite, Danielle Steel. *TW: brief mention of sexual assault* Books we referenced: The Overstory by Richard Powers Little Weirds by Jenny Slate The Other End of the Leash by Patricia McConnell  In the Dream House by Carmen Maria Machado Dog Songs by Mary Oliver Muggie Maggie by Beverly Cleary  Study References: Kidd, David Comer, and Emanuele Castano. “Reading literary fiction improves theory of mind.” Science (New York, N.Y.) vol. 342,6156 (2013): 377-80. doi:10.1126/science.1239918 Berns, Gregory S et al. “Short- and long-term effects of a novel on connectivity in the brain.” Brain connectivity vol. 3,6 (2013): 590-600. doi:10.1089/brain.2013.0166 Cain, Kate, and Jane Oakhill. “Matthew effects in young readers: reading comprehension and reading experience aid vocabulary development.” Journal of learning disabilities vol. 44,5 (2011): 431-43. doi:10.1177/0022219411410042 Gualano, M R et al. “The long-term effects of bibliotherapy in depression treatment: Systematic review of randomized clinical trials.” Clinical psychology review vol. 58 (2017): 49-58. doi:10.1016/j.cpr.2017.09.006

「2013年臺灣曾製作一份國民幸福感問卷，結果有媒體披露，其中有一題問『你家有幾個馬桶？』引起一番論戰，到底幸不幸福跟馬桶有何關係？」 本集重點 。娜娜心理師陪你聊心事： 焦慮恐慌時該怎麼辦 (01:28) 。你認同，金錢能帶來真正快樂嗎？(05:55) 。馬桶跟你幸不幸福有何關係 (07:43) 。花錢買時間，幫自己爭取喘息空間 (10:18) 。花錢買體驗，在平凡中增添獨特感 (15:22) 。花錢給別人，不只拉近彼此還創造餘裕感 (21:30) 。回覆聽眾留言(27:24) [註一] 娜娜心理師提到的「腹式呼吸」： http://yourpsy.piee.pw/SBYB4 [註二]本集提到的研究： 花錢買時間會比較快樂 Whillans, A. V., Dunn, E. W., Smeets, P., Bekkers, R., & Norton, M. I. (2017). Buying time promotes happiness. Proceedings of the National Academy of Sciences, 114(32), 8523-8527. 把錢花在他人身上會比較快樂 Dunn, Elizabeth & Aknin, Lara & Norton, Michael. (2008). Spending Money on Others Promotes Happiness. Science (New York, N.Y.). 319. 1687-8. ___ 若你覺得我們節目不錯，請記得要訂閱哦。也歡迎來跟我們聊聊 哇賽！心理學 臉書粉絲專頁 https://www.facebook.com/onyourpsy/ Telegram頻道 https://t.me/onyourpsy IG帳號 www.instagram.com/onyourpsy/ ___ 本系列使用音樂：youtube音效庫 https://www.youtube.com/audiolibrary/music?nv=1 主談：蔡宇哲 統籌：N. Powered by Firstory Hosting